AndreaBozzo/ceres-open-data-index huggingface dataset:
2018 Uniform Reporting System (URS) Table for Minnesota

This is the 2018 Uniform Reporting System (URS) Output Tables for Minnesota. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-data, community-mental-health, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Antizyme expression: a subversion of triplet decoding, which is remarkably conserved by evolution, is a sensor for an autoregulatory circuit

The efficiency of programmed ribosomal frameshifting in decoding antizyme mRNA is the sensor for an autoregulatory circuit that controls cellular polyamine levels in organisms ranging from the yeast Schizosaccharomyces pombe to Drosophila to mammals. Comparison of the frameshift sites and flanking stimulatory signals in many organisms now permits a reconstruction of the likely evolutionary path of the remarkably conserved mRNA sequences involved in the frameshifting.

Tags: antizyme, antizyme-expression, nih, polyamine-levels, ribosomal-frameshifting
Organization: U.S. Department of Health & Human Services
Catecholamine-induced interleukin-10 release: a key mechanism in systemic immunodepression after brain injury

Background:
          Infections after severe brain injury or polytrauma are still a problem, and may be the result of a brain-mediated disturbed systemic immunoreactivity. The mechanism that connects initial brain affection and systemic immunodepression, however, is still poorly understood.
        
        
          Review:
          In order to analyze the influence of the sympathetic nervous system in the context of brain injury on systemic immune functions, we performed various in vitro, in vivo and clinical studies. We were able to demonstrate that catecholamines trigger the release of the strong anti-inflammatory cytokine interleukin (IL)-10 from peripheral blood mononuclear cells and monocytes. In animal models we were able to show that increased intracranial pressure as well as intracerebral proinflammatory cytokines (eg IL-1β) produce a rapid systemic IL-10 release through sympathetic activation. Thus, in both models, the predominant role of catecholamines for this effect was confirmed by the complete prevention of IL-10 increase after β-adrenoreceptor blockade. Moreover, in clinical studies we clearly demonstrated that neurosurgical procedures involving brain-stem manipulation invoke sympathetic activation and a rapid systemic IL-10 release. Remarkably, this was associated with monocytic deactivation – a sign of systemic immunodepression and a high risk of infectious complications.Finally, these data were validated in patients with accidental brain injury, in whom we demonstrated a correlation between the severity of injury, sympathetic activation, IL-10 plasma levels and the incidence of infectious complications.
        
        
          Conclusion:
          In summary, we suppose that activation of inhibitory neuroimmune pathways like the sympathetic nervous system, but also the hypothalamic-pituitary-adrenal axis, may trigger a systemic anti-inflammatory response syndrome that leads to systemic immunodepression. In this process the catecholamine-mediated systemic IL-10 release that causes monocytic deactivation may be a key mechanism.

Tags: brain-injury, catecholamines, immunodepression, interleukin-10, nih
Organization: U.S. Department of Health & Human Services
Tobacco Product and Alcohol Use Tables (Standard Errors and P Values) - 2.1 to 2.84

These detailed tables present standard errors for totals and prevalence estimates of tobacco and alcohol use from the 2010 National Survey on Drug Use and Health (NSDUH). Tobacco products include cigarettes, smokeless tobacco, cigars, and pipe tobacco. Alcohol use includes binge and heavy alcohol use. Standard errors are provided for lifetime, past year, and past month use by age group, gender, race/ethnicity, education level, employment status, and geographic area. Standard errors are provided for both 2010 and 2009.

Tags: nsduh-2010, samhsa, standard-errors, substance-use-prevalence, tobacco-alcohol-use
Organization: U.S. Department of Health & Human Services
2010 CMHS Uniform Reporting System (URS) Output Tables for Alabama

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2010. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-program, community-mental-health, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
2014 Mental Health Client-Level Data Report (MH-CLD)

This report presents results from the Mental Health Client Level Data (MH-CLD) and Mental Health Treatment Episode Set (MH-TEDS) for individuals receiving mental health treatment services in 2014, as well as selected data collection trends for such individuals from 2011 to 2014. The report provides information on mental health diagnoses, mental health treatment services, and demographic and substance use characteristics of individuals in mental health treatment in facili-ties that reported to individual state administrative data systems. One chapter is also devoted to characteristics of admissions to and discharges from mental health treatment, which can feature the same individual on multiple occasions.

Tags: client-level-data, mental-health-diagnoses, mental-health-treatment, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
The lung as a route for systemic delivery of therapeutic proteins and peptides

The large surface area, good vascularization, immense capacity for solute exchange and ultra-thinness of the alveolar epithelium are unique features of the lung that can facilitate systemic delivery via pulmonary administration of peptides and proteins. Physical and biochemical barriers, lack of optimal dosage forms and delivery devices limit the systemic delivery of biotherapeutic agents by inhalation. Current efforts to overcome these difficulties in order to deliver metabolic hormones (insulin, calcitonin, thyroid-stimulating hormone [TSH], follicle-stimulating hormone [FSH] and growth hormones) systemically, to induce systemic responses (immunoglobulins, cyclosporin A [CsA], recombinant-methionyl human granulocyte colony-stimulating factor [r-huG-CSF], pancreatic islet autoantigen) and to modulate other biological processes via the lung are reviewed. Safety aspects of pulmonary peptide and protein administration are also discussed.

Tags: nih, peptide-delivery, pulmonary-drug-delivery, systemic-absorption, therapeutic-proteins
Organization: U.S. Department of Health & Human Services
Advantages of larval control for African malaria vectors: Low mobility and behavioural responsiveness of immature mosquito stages allow high effective coverage

Background
          Based on sensitivity analysis of the MacDonald-Ross model, it has long been argued that the best way to reduce malaria transmission is to target adult female mosquitoes with insecticides that can reduce the longevity and human-feeding frequency of vectors. However, these analyses have ignored a fundamental biological difference between mosquito adults and the immature stages that precede them: adults are highly mobile flying insects that can readily detect and avoid many intervention measures whereas mosquito eggs, larvae and pupae are confined within relatively small aquatic habitats and cannot readily escape control measures.
        
        
          Presentation of the hypothesis
          We hypothesize that the control of adult but not immature mosquitoes is compromised by their ability to avoid interventions such as excito-repellant insecticides.
        
        
          Testing the hypothesis
          We apply a simple model of intervention avoidance by mosquitoes and demonstrate that this can substantially reduce effective coverage, in terms of the proportion of the vector population that is covered, and overall impact on malaria transmission. We review historical evidence that larval control of African malaria vectors can be effective and conclude that the only limitations to the effective coverage of larval control are practical rather than fundamental.
        
        
          Implications of the hypothesis
          Larval control strategies against the vectors of malaria in sub-Saharan Africa could be highly effective, complementary to adult control interventions, and should be prioritized for further development, evaluation and implementation as an integral part of Rolling Back Malaria.

Tags: intervention-avoidance, larval-control, malaria-control, mosquito-vectors, nih
Organization: U.S. Department of Health & Human Services
Venous oxygen measurements in the inferior vena cava in neonates with respiratory failure

Background:
          The present study was undertaken to examine the feasibility of venous oxygen measurements in the inferior vena cava (IVC) via a catheter through the umbilical vein. This may serve as a proxy for mixed venous oxygenation and the complications of right atrial cannulation can be avoided at the same time. It has the added advantage of not being affected by atrial right-left shunting.
        
        
          Results:
          The study included 22 neonates requiring mechanical ventilation for respiratory insufficiency. The success rate of catheterization of the IVC via the umbilical vein was 81% and there was no catheter-related complications. Fifty paired blood samples were obtained and analyzed while the patients were hemodynamically stable. Linear regression analysis showed a poor correlation between arterial oxygen tension (PaO2) and the arterial-venous oxygen content difference [C(a–v)O2], r = -0.005, and between PaO2 and the fractional oxygen extraction (FOE), r = -0.114. There was also a poor correlation between arterial oxygen saturation (SaO2) and C(a–v)O2, r = -0.057, and between SaO2 and FOE, r =-0.139. The correlations between venous oxygen tension (PvO2) and C(a–v)O2 and between PvO2 and FOE were r = -0.528 and r = 0.592, respectively. There were good correlations between various oxygen saturation (SvO2) and C(a–v)O2, r = -0.634, and between SvO2 FOE, r = -0.712.
        
        
          Conclusion:
          Venous oxygen measurement in the IVC via an umbilical vein catheter is a simple and safe procedure and provides information about the tissue oxygenation status of critically ill neonates.

Tags: inferior-vena-cava, neonatal-respiratory-failure, nih, umbilical-catheterization, venous-oxygen-saturation
Organization: U.S. Department of Health & Human Services
Utah (UT)

This report presents estimates for measures of substance use and mental health based on the combined 2010 and 2011 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for Utah for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: ami-smi-mde, mental-health, samhsa, substance-use, utah-survey
Organization: U.S. Department of Health & Human Services
National Directory of Drug and Alcohol Abuse Treatment Facilities 2004

The National Directory of Drug and Alcohol Abuse Treatment Programs 2004 lists federal, state, local, and private facilities that provide substance abuse treatment services. The directory includes treatment facilities that are licensed, certified, or otherwise approved for inclusion in the directory by their state substance abuse agencies and that responded to the 2003 National Survey of Substance Abuse Treatment Services (N-SSATS). The information about each facility that appears in this directory was provided by that facility in response to the 2003 N-SSATS. The Substance Abuse and Mental Health Services Administration (SAMHSA) conducts the N-SSATS annually.

Tags: alcohol-abuse-treatment, n-ssats, samhsa, substance-abuse-treatment, treatment-facility-directory
Organization: U.S. Department of Health & Human Services
Chicago: Drug-Related Emergency Department Visits, 2004-2011 - Nonmedical Use of Pharmaceuticals

Excel file with estimates, rates, relative standard errors, trends and confidence intervals for all drug-related emergency department (ED) visits involving the nonmedical use of pharmaceuticals (prescription and over-the-counter medications and dietary supplements) for the Chicago metropolitan area, covering 2004-2011.  Nonmedical use includes patients who took a higher than prescribed or recommended dose of their own medication, patients who took a pharmaceutical prescribed for another person, malicious poisoning of the patient by another individual, and documented substance abuse involving pharmaceuticals.

Tags: chicago-health, drug-related-ed, emergency-department-visits, pharmaceutical-misuse, samhsa
Organization: U.S. Department of Health & Human Services
Bacterial cholangitis causing secondary sclerosing cholangitis: A case report

Background
          Although bacterial cholangitis is frequently mentioned as a cause of secondary sclerosing cholangitis, it appears to be extremely rare, with only one documented case ever reported.
        
        
          Case presentation
          A 48-year-old woman presented with an episode of acute biliary pancreatitis that was complicated by pancreatic abcess formation. After 3 months she had an episode of severe pyogenic (E. Coli) cholangitis that recurred over the subsequent 7 months on a further two occasions. Initially, cholangiography suggested the presence of extra-biliary intrahepatic abcesses while repeated investigations demonstrated development of multiple segmental biliary duct strictures. After maintenance antibiotic treatment was started, no episodes of cholangitis occurred over a 14-month period.
        
        
          Conclusions
          Sclerosing cholangitis can rapidly develop after an episode of bacterial cholangitis. Extra-biliary involvement of the hepatic parenchyma with abcess formation may be a risk factor for developing this rare but particularly severe complication.

Tags: bacterial-cholangitis, biliary-strictures, e-coli-infection, nih, sclerosing-cholangitis
Organization: U.S. Department of Health & Human Services
Medicinal and ethnoveterinary remedies of hunters in Trinidad

Background
          Ethnomedicines are used by hunters for themselves and their hunting dogs in Trinidad. Plants are used for snakebites, scorpion stings, for injuries and mange of dogs and to facilitate hunting success.
        
        
          Results
          Plants used include Piper hispidum, Pithecelobium unguis-cati, Bauhinia excisa, Bauhinia cumanensis, Cecropia peltata, Aframomum melegueta, Aristolochia rugosa, Aristolochia trilobata, Jatropha curcas, Jatropha gossypifolia, Nicotiana tabacum, Vernonia scorpioides, Petiveria alliacea, Renealmia alpinia, Justicia secunda, Phyllanthus urinaria,Phyllanthus niruri,Momordica charantia, Xiphidium caeruleum, Ottonia ovata, Lepianthes peltata, Capsicum frutescens, Costus scaber, Dendropanax arboreus, Siparuma guianensis, Syngonium podophyllum, Monstera dubia, Solanum species, Eclipta prostrata, Spiranthes acaulis, Croton gossypifolius, Barleria lupulina, Cola nitida, Acrocomia ierensis (tentative ID).
        
        
          Conclusion
          Plant use is based on odour, and plant morphological characteristics and is embedded in a complex cultural context based on indigenous Amerindian beliefs. It is suggested that the medicinal plants exerted a physiological action on the hunter or his dog. Some of the plants mentioned contain chemicals that may explain the ethnomedicinal and ethnoveterinary use. For instance some of the plants influence the immune system or are effective against internal and external parasites. Plant baths may contribute to the health and well being of the hunting dogs.

Tags: ethnoveterinary-medicine, medicinal-plants, nih, traditional-medicine, trinidad-tobago
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Wyoming, 2015

This is a behavioral health report for the state of Wyoming. The report utilizes data from the National Survey on Drug Use and Health (NSDUH), and the Uniform Reporting System. The topics addressed in the report include youth substance use, youth mental health and treatment, mental health and treatment, substance use and substance use treatment.

Tags: mental-health-treatment, samhsa, substance-use-treatment, wyoming-behavioral-health, youth-substance-use
Organization: U.S. Department of Health & Human Services
2013 NSDUH Miscellaneous Tables  (Prevalence Estimates) - 6.1 to 6.107

These detailed tables present totals and prevalence estimates of the number of days and types of substance use, poly-drug use, nicotine dependence, substance dependence by age of first use, source of substances, social context of substance use, and drunk/drugged driving from the 2013 National Survey on Drug Use and Health (NSDUH). Substances examined include illicit drugs, marijuana, cocaine, heroin, hallucinogens, inhalants, and the nonmedical use of prescription-type pain relievers, tranquilizers, stimulants, and sedatives, and alcohol. Results are provided for lifetime, past year, and past month use by age group, gender, race/ethnicity, education level, employment status, geographic area, pregnancy status, college enrollment status, and probation/parole status. Comparisons are made between 2013 and 2012.

Tags: drug-prevalence, nsduh-2013, poly-drug-use, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
2022 NSDUH Detailed Tables

Get detailed national estimates from the 2022 National Survey on Drug Use and Health (NSDUH). The tables provide comprehensive statistics on substance use, mental health, and treatment in the United States.The tables are based on the NSDUH survey, which interviews people ages 12 or older in the civilian, noninstitutionalized population. In the tables, indicators are broken out by a variety of demographic, geographic, and economic variables.The following topics are covered, among others: drug, alcohol, nicotine, and tobacco product use and initiation; substance use disorder (SUD); substance use risk and protective factors; availability of substance use treatment; any mental illness (AMI) and serious mental illness (SMI); major depressive episode (MDE); suicidal thoughts and behaviors; serious psychological distress (SPD); mental health treatment; and co-occurrence of mental health issues and SUDs.The tables include estimates from 2021 and 2022 where appropriate, including statistical tests of differences between the two years. The 2021 estimates presented in these detailed tables are based on weights that were adjusted to allow for comparison with 2022. As a result, the NSDUH estimates for 2021 presented in the 2022 Detailed Tables may be different from the 2021 estimates previously published elsewhere. For more information on the creation of the revised weights for 2021, see the2022 Methodological Summary and Definitionsreport.All of the tables can be downloaded in a zip file which contains both an HTML and PDF file containing every table. Alternatively, users can open the clickable Table of Contents to go to a particular section. Click on “PE” to get to a population estimate or percentage table, and “SE” to get a standard error table

Tags: mental-health, samhsa, substance-use, sud-treatment, suicidal-ideation
Organization: U.S. Department of Health & Human Services
2020 Uniform Reporting System (URS) Table For West Virginia

This is the 2020 Uniform Reporting System (URS) Output Tables for West Virginia. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: mental-health-services, national-outcome-measures, samhsa, substance-abuse, west-virginia
Organization: U.S. Department of Health & Human Services
2013 NSDUH Data Collection Final Report

NSDUH is funded by the Substance Abuse and Mental Health Services Administration (SAMHSA), an agency of the U.S. Public Health Service in the U.S. Department of Health and Human Services. SAMHSA contracted with RTI Internationalto conduct activities including sampling, counting and listing, screening, interviewing, data processing, and reporting. This report examines the preparations and procedures used in carrying out the data collection tasks and also presents the results of data collection.  This report addresses the following topics relating to data collection for the 2013 NSDUH: Sampling and Counting and Listing Operations, Data Collection Staffing, Preparation of Survey Materials, Field Staff Training, Data Collection, Data Collection Results, and Quality Control.

Tags: data-collection, mental-health, samhsa, substance-use, survey-methodology
Organization: U.S. Department of Health & Human Services
Phylogenetic variation and polymorphism at the Toll-like receptor 4 locus (

Background:
          Differences in responses to bacterial surface lipopolysaccharides (LPSs) are apparent between and within mammalian species. It has been shown in mice that resistance to LPS is caused by defects in the Toll-like receptor 4 gene (Tlr4), the product of which is thought to bind LPS and mediate LPS signal transduction in immune system cells.
        
        
          Results:
          We have sequenced the Toll-like receptor 4 gene of humans (TLR4; 19.0 kilobases, kb) and mice (Tlr4; 91.7 kb), as well as the coding region and splice junctions of Tlr4 from 35 mouse (Mus musculus) strains, from the chimpanzee and from the baboon. No other discernible genes or regions of interspecies conservation lies close to Tlr4 and, in both humans and mice, flanking sequences and introns are rich in repeats of retroviral origin. Interstrain analyses reveal that Tlr4 is a polymorphic protein and that the extracellular domain is far more variable than the cytoplasmic domain, both among strains and among species. The cytoplasmic domain of the Tlr4 protein is highly variable at the carboxy-terminal end.
        
        
          Conclusions:
          We suggest that selective evolutionary pressure exerted by microbes expressing structurally distinguishable LPS molecules has produced the high level of variability in the Tlr4 extracellular domain. The highly variable carboxy-terminal region of the cytoplasmic domain is likely to determine the magnitude of the response to LPS within a species.

Tags: genetic-polymorphism, lipopolysaccharides-response, nih, tlr4-gene, toll-like-receptor-4
Organization: U.S. Department of Health & Human Services
2020 Uniform Reporting System (URS) Table For Virgin Islands

This is the 2020 Uniform Reporting System (URS) Output Tables for Virgin Islands. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-program, mental-health-services, national-outcome-measures, samhsa, virgin-islands
Organization: U.S. Department of Health & Human Services