AndreaBozzo/ceres-open-data-index huggingface dataset:
Rheumatoid arthritis associated autoantibodies in patients with synovitis of recent onset

An inception cohort of 238 patients having peripheral joint synovitis of less than 12 months duration was evaluated clinically and followed prospectively for 1 year to determine the clinical significance of a number of rheumatoid arthritis (RA) associated autoantibodies. Serum samples collected at the time of the initial evaluation were tested for rheumatoid factor (RF) and antibodies to Sa (anti-Sa), RA-33, (pro)filaggrin [antifilaggrin antibody (AFA)], cyclic citrullinated peptide (anti-CCP), calpastatin, and keratin [antikeratin antibody (AKA)]. RF had a sensitivity of 66% and a specificity of 87% for RA. Anti-Sa, AFA, and anti-CCP all had a specificity of more than 90%, but a sensitivity of less than 50% for this diagnosis. Overall, there was a high degree of correlation between AFA, AKA, anti-Sa or anti-CCP, this being highest between anti-Sa and anti-CCP (odds ratio, 13.3; P < 0.001). Of the 101 patients who were positive for at least one of these four autoantibodies, 57% were positive for only one. Finally, anti-SA identified a subset of predominantly male RA patients with severe, erosive disease. Anti-SA, AFA and anti-CCP are all specific for early RA but, overall, have little additional diagnostic value over RF alone. Although these antibodies may preferentially recognize citrullinated antigens, the modest degree of concordance between them in individual patient sera suggests that it is unlikely a single antigen is involved in generating these responses.

Tags: anti-ccp-antibodies, autoantibody-profiling, nih, rheumatoid-arthritis, synovitis
Organization: U.S. Department of Health & Human Services
Compound 528694: 1-Methyl-2-(1-methylpropyl)benzene

Chemical compound data from PubChem database. IUPAC Name: 1-butan-2-yl-2-methylbenzene. Molecular Formula: C11H16. Molecular Weight: 148.24. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Combined antibiotic and free radical trap treatment is effective at combating

Although early antibiotic treatment of patients with septic arthritis eradicates bacteria, joint destruction commonly results from the unregulated host inflammatory responses to infection. The spin trap compound phenyl-N-tert-butyl nitrone (PBN) has been shown to have both anti-inflammatory and antioxidant effects. The aim of this study was to assess the effect of combined systemic administration of PBN and cloxacillin on the development of Staphylococcus aureus arthritis.
        Three days after Naval Medical Research Institute (NMRI) mice were infected intravenously with S. aureus LS-1, daily treatment was started with cloxacillin alone, PBN alone, or cloxacillin and PBN. Arthritis, weight loss and general condition were evaluated for each mouse, and joints were analyzed histopathologically. Systemic administration of PBN in conjunction with cloxacillin ameliorated the course of experimental S. aureus arthritis, as evidenced by an increased cure rate. Thus, combinatorial antioxidant plus antibiotic anti-inflammatory therapies represent a potentially efficacious approach to the management of septic arthritis.

Tags: anti-inflammatory, antibiotic-treatment, nih, septic-arthritis, staphylococcus-aureus
Organization: U.S. Department of Health & Human Services
Compound 526647: Benzene, 1,2-dichloro-4-((2,4-dichlorophenyl)methyl)-5-methyl-

Chemical compound data from PubChem database. IUPAC Name: 1,2-dichloro-4-[(2,4-dichlorophenyl)methyl]-5-methylbenzene. Molecular Formula: C14H10Cl4. Molecular Weight: 320.0. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Patent AT-E401512-T1: [Translated] METHOD FOR TEMPERATURE-DEPENDENT CONTROL OF A DISC CLUTCH

The invention relates to a method for temperature-dependant control of a multiple disc clutch in the drive train of a motor vehicle, comprising an input component, an output component and clutch discs for the transmission of torque between the two components. If a difference in the number of revolutions between the input component and the output component takes place, frictioning provoking heating of the coupling discs occurs. The inventive method includes the following steps: during operation at a first temperature T1 which is below a defined, permanently admissible temperature, the disc coupling is controlled depending on traction requirement; during operation between a first temperature T1 and a second higher temperature T2, the disc coupling is controlled in such a way that the frictioning applied is reduced; during operation above the first temperature T1, the second temperature T2 is set lower; if the second temperature T2 is surpassed, the disc coupling is controlled in such a way that the temperature specific to the clutch decreases.

Tags: chemistry, innovation, patent, pubchem, research
Organization: U.S. Department of Health & Human Services
Chromosomal aberrations in benign and malignant Bilharzia-associated bladder lesions analyzed by comparative genomic hybridization

Background
          Bilharzia-associated bladder cancer (BAC) is a major health problem in countries where urinary schistosomiasis is endemic. Characterization of the genetic alterations in this cancer might enhance our understanding of the pathogenic mechanisms of the disease but, in contrast to nonbilharzia bladder cancer, BAC has rarely been the object of such scrutiny. In the present study, we aimed to characterize chromosomal imbalances in benign and malignant post-bilharzial lesions, and to determine whether their unique etiology yields a distinct cytogenetic profile as compared to chemically induced bladder tumors.
        
        
          Methods
          DNAs from 20 archival paraffin-embedded post-bilharzial bladder lesions (6 benign and 14 malignant) obtained from Sudanese patients (12 males and 8 females) with a history of urinary bilharziasis were investigated for chromosomal imbalances using comparative genomic hybridization (CGH). Subsequent FISH analysis with pericentromeric probes was performed on paraffin sections of the same cases to confirm the CGH results.
        
        
          Results
          Seven of the 20 lesions (6 carcinomas and one granuloma) showed chromosomal imbalances varying from 1 to 6 changes. The most common chromosomal imbalances detected were losses of 1p21-31, 8p21-pter, and 9p and gain of 19p material, seen in three cases each, including the benign lesion.
        
        
          Conclusion
          Most of the detected imbalances have been repeatedly reported in non-bilharzial bladder carcinomas, suggesting that the cytogenetic profiles of chemical- and bilharzia-induced carcinomas are largely similar. However, loss of 9p seems to be more ubiquitous in BAC than in bladder cancer in industrialized countries.

Tags: bladder-cancer, chromosomal-aberrations, comparative-genomic-hybridization, nih, schistosomiasis
Organization: U.S. Department of Health & Human Services
Compound 525690: p-Chlorobenzylidene-octyl-amine

Chemical compound data from PubChem database. IUPAC Name: 1-(4-chlorophenyl)-N-octylmethanimine. Molecular Formula: C15H22ClN. Molecular Weight: 251.79. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Calculated conformer energies for organic molecules with multiple polar functionalities are method dependent: Taxol (case study)

Background
          Molecular mechanics (MM) and quantum chemical (QM) calculations are widely applied and powerful tools for the stereochemical and conformational investigations of molecules. The same methods have been extensively used to probe the conformational profile of Taxol (Figure 1) both in solution and at the β-tubulin protein binding site.
        
        
          Results
          In the present work, the relative energies of seven conformations of Taxol derived from NMR and X-ray analyses were compared with a set of widely used force fields and semiempirical MO methods coupled to a continuum solvent treatment. The procedures not only diverge significantly in their assessment of relative conformational energies, but none of them provide satisfactory agreement with experiment.
        
        
          Conclusions
          For Taxol, molecular mechanics and semiempirical QM methods are unable to provide a consistent energetic ranking of side-chain conformations. For similar highly polar organic structures, "energy-free" conformational search methods are advised.

Tags: conformational-energies, molecular-mechanics, nih, quantum-chemical-calculations, taxol-conformations
Organization: U.S. Department of Health & Human Services
Publications Using SAMHSA DataMontana (MT)

This report presents Montana\'s estimates for 25 measures of substance use and mental health based on the combined 2009 and 2010 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for Montana for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: mental-health, montana, nsduh, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
2018 Uniform Reporting System (URS) Table for Texas

This is the 2018 Uniform Reporting System (URS) Output Tables for Texas. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-program, mental-health-services, national-outcome-measures, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
Synthesis of Findings from the Title IV-E Flexible Funding Waiver Demonstrations

This report is based on evaluation reports from and site visits to the following states regarding their title IV-E waivers to implement flexible funding demonstration projects: California, Florida, Indiana, North Carolina, Ohio, and Oregon.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: child, fiscal, policy, scope, state
Organization: U.S. Department of Health & Human Services
Compound 529457: 4a-methyl-7-prop-1-en-2-yl-4,5,6,7,8,8a-hexahydro-3H-naphthalene-1-carboxylic acid

Chemical compound data from PubChem database. IUPAC Name: 4a-methyl-7-prop-1-en-2-yl-4,5,6,7,8,8a-hexahydro-3H-naphthalene-1-carboxylic acid. Molecular Formula: C15H22O2. Molecular Weight: 234.33. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 525209: Chloromethyl 4-chloropentanoate

Chemical compound data from PubChem database. IUPAC Name: chloromethyl 4-chloropentanoate. Molecular Formula: C6H10Cl2O2. Molecular Weight: 185.05. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 527790: Benzoic acid, 3-chloro, 2-propenyl ester

Chemical compound data from PubChem database. IUPAC Name: prop-2-enyl 3-chlorobenzoate. Molecular Formula: C10H9ClO2. Molecular Weight: 196.63. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Supporting Evidence-Based Home Visitation Programs to Prevent Child Abuse and Neglect Project: DePelchin Children's Center

Location:

Dickinson, Texas City, Santa Fe, and La Marque, Texas

Home Visiting Program Selected:

Positive Parenting Program

Home Visiting Target Population:

Families with children between 0-16 years old at risk for child maltreatment

Project Overview:
The DePelchin Children's Center will implement the Positive Parenting Program (Triple P), in four high-need communities in southeast Texas through the establishment of the Healthy Solutions Program. The goals of the Healthy Solutions Program are: (1) to provide home based family support, prevention and parenting services to at-risk families; (2) to build upon existing infrastructure of collaborative partnerships to implement and sustain evidence-based home visitation programs; and (3) to contribute to the knowledge and research base of child abuse prevention through rigorous evaluation. DePelchin will work collaboratively with a broad range of local stakeholders to build an infrastructure and leverage existing funds and resources to ensure the sustainability of these services. To address concerns with continuity of care, DePelchin will develop a referral system for enrolled families. DePelchin will evaluate their home visiting approach through a randomized control evaluation.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: abuse, intervention, maltreatment, neglect, prevention
Organization: U.S. Department of Health & Human Services
Report to Congress: Feasibility of Uniform Data Collection on "Shaken Baby Syndrome" or Abusive Head Trauma

This report represents the HHS response to the requirement to conduct a feasibility assessment of the mandated report on shaken baby syndrome, referenced herein primarily as AHT, the more inclusive term recommended by the American Academy of Pediatrics (AAP). The assessment included a literature review on incidence of AHT; identification of related federal activities, including activities authorized under CAPTA; stakeholder discussions; and broad consideration of benefits and costs involved.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: assessment, policy, reporting, surveillance, trauma
Organization: U.S. Department of Health & Human Services
Compound 526440: 1,2,3,4,6,7,8,9-Octahydro-pyrido[2,1-b]quinazolin-11-one

Chemical compound data from PubChem database. IUPAC Name: 1,2,3,4,6,7,8,9-octahydropyrido[2,1-b]quinazolin-11-one. Molecular Formula: C12H16N2O. Molecular Weight: 204.27. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Debate: Do all patients with heart failure require automatic implantable defibrillators for the prevention of sudden death?

Recent clinical trials indicate that approximately two-thirds of patients in New York Heart Association (NYHA) class II and III, who comprise almost 90% of patients with heart failure, die suddenly. Patients in NYHA class IV usually die of progressive heart failure. Implantation of implantable cardioverters defibrillators (ICDs) in this population would represent a huge logistic problem and economic expense. Clinical trials have recently demonstrated that β-blocker therapy with carvedilol, bisoprolol, and toprol XL decrease the sudden death rate by almost 50%, in addition to impacting significantly on death due to worsening heart failure. This medical approach is beneficial to all patients, and should be our major therapy. However, it is reasonable to attempt to identify that subpopulations of heart failure patients who could benefit from an ICD.

Tags: beta-blockers, heart-failure, icd-therapy, nih, sudden-cardiac-death
Organization: U.S. Department of Health & Human Services
Compound 525571: N,N-Dimethyl-N'-(3-ethoxyphenyl)-p-methoxybenzamidine

Chemical compound data from PubChem database. IUPAC Name: N'-(3-ethoxyphenyl)-4-methoxy-N,N-dimethylbenzenecarboximidamide. Molecular Formula: C18H22N2O2. Molecular Weight: 298.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 526628: 2-{2-[2-(2-Diethylamino-ethoxy)-eth oxy]-ethoxy}-ethanol

Chemical compound data from PubChem database. IUPAC Name: 2-[2-[2-[2-(diethylamino)ethoxy]ethoxy]ethoxy]ethanol. Molecular Formula: C12H27NO4. Molecular Weight: 249.35. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 526057: trans-Ethyl-2-propyl-diazene

Chemical compound data from PubChem database. IUPAC Name: ethyl(propan-2-yl)diazene. Molecular Formula: C5H12N2. Molecular Weight: 100.16. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2018 Uniform Reporting System (URS) Table for Wisconsin

This is the 2018 Uniform Reporting System (URS) Output Tables for Wisconsin. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant, mental-health-services, outcome-measures, samhsa, wisconsin
Organization: U.S. Department of Health & Human Services
NSDUH 2022 Methodological Resource Book (MRB)

Use this collection to provide context for estimates from the National Survey on Drug Use and Health (NSDUH). This collection includes materials used to conduct the survey, reports on how the survey was conducted, and reports on how the data were processed. The Statistical Inference Report details how the data were analyzed for reports and tables, which may be useful for data users looking to do their own analysis.New items are added to the collection as they become available, so resources published in a previous MRB may not yet be available for 2022. However, there are generally few changes from year to year, and a report from a previous year may have the information you are looking for.

Tags: data-analysis, mental-health, samhsa, substance-use, survey-methodology
Organization: U.S. Department of Health & Human Services
Boston: Drug-Related Emergency Department Visits, 2004-2011 - All Misuse and Abuse

Excel file with estimates, rates, relative standard errors, trends and confidence intervals for all drug-related emergency department (ED) visits involving drug misuse or abuse in the Boston metropolitan area, covering 2004-2011. Drug misuse/abuse visits include the use of illicit drugs, nonmedical use of pharmaceuticals, underage drinking and visits where alcohol was combined with another drug.

Tags: boston-metro-area, drug-related-ed-visits, emergency-department, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
Patent AT-E40150-T1: [Translated] DETERGENT BUILDER.

A granulated detergent builder is disclosed comprising: 65 to 85 weight percent of a water insoluble silicate capable of binding calcium, in the form of a finely dispersed, bound-water-containing, synthetically produced, water insoluble crystalline compound having the general formula: (Cat2/nO)x.Me2O3.(SiO2)y (I),  in which Cat is a cation exchangeable with calcium with the valency n, x is a number from 0.7 to 1.5, Me is boron or aluminum, and y a number from 0.8 to 6, 4 to 10 weight percent sodium nitrilotriacetate 1.5 to 3 weight percent nonionic surfactant 0 to 1 weight percent alkali 0.5 to 1.5 weight percent carboxymethyl cellulose and/or methylcellulose and the balance is water. The product can be produced by spray drying an aqueous suspension in which all ingredients are dispersed or dissolved.

Tags: chemistry, innovation, patent, pubchem, research
Organization: U.S. Department of Health & Human Services
Youth Mental Health Tables (Standard Errors and P Values) - 2.1 to 2.14

These detailed tables present standard errors for totals and prevalence estimates of mental health related issues among adolescents aged 12 to 17 from the 2012 National Survey on Drug Use and Health (NSDUH). Tables with data on ayouths include measures on mental health service utilization, MDE, treatment for depression (among youths with MDE), and co-occurrence of mental disorders with substance use or with substance use disorders. Results are provided by age group, gender, race/ethnicity, education level, county type, poverty level, insurance status, overal health, and geographic area. Comparisons are made between 2012 and 2011.

Tags: adolescent-depression, mental-health-services, nsduh-2012, samhsa, youth-mental-health
Organization: U.S. Department of Health & Human Services
Compound 528934: Benzaldehyde, 2-hydroxy-5-tert.-butyl, TMS

Chemical compound data from PubChem database. IUPAC Name: 5-tert-butyl-2-trimethylsilyloxybenzaldehyde. Molecular Formula: C14H22O2Si. Molecular Weight: 250.41. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 527633: Propyl N-methyl carbamate

Chemical compound data from PubChem database. IUPAC Name: propyl N-methylcarbamate. Molecular Formula: C5H11NO2. Molecular Weight: 117.15. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 528536: Hexadecane, 7-heptyl

Chemical compound data from PubChem database. IUPAC Name: 8-hexylheptadecane. Molecular Formula: C23H48. Molecular Weight: 324.6. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services