AndreaBozzo/ceres-open-data-index huggingface dataset:
Update: Drug-Related Emergency Department Visits Involving Synthetic Cannabinoids

This short report uses data on drug-related emergency department (ED) visits from the Drug Abuse Warning Network to look at 2011 ED visits involving synthetic cannabinoids.  It shows trends compared to 2010 by gender, age group, the age distribution of patients, the drugs most commonly combined with synthetic cannabinoids and the outcome of the ED visits.

Tags: drug-abuse, ed-visits, emergency-department, samhsa, synthetic-cannabinoids
Organization: U.S. Department of Health & Human Services
2019 N-SSATS State Profiles

These state profiles include data from facilities that reported to N-SSATS for the survey reference date March 29, 2019. The N-SSATS collects data on the location, characteristics, services offered, and number of clients (collected every other year) in treatment at alcohol and drug abuse treatment facilities (public and private) throughout the 50 states, the District of Columbia, U.S. territories, and other jurisdictions.

Tags: mental-health-services, n-ssats, samhsa, substance-abuse-treatment, treatment-facility-data
Organization: U.S. Department of Health & Human Services
National Survey on Drug Use and Health: Statistical Models to Predict Mental Illness from 2005 to 2007

Given the analytic benefits of having comparable indicators of SMI and AMI for additional years of NSDUH data, this report explores whether new models could be developed from the MHSS data to generate 2005 to 2007 estimates of SMI and AMI that would be comparable with the 2008 and later estimates.

Tags: mental-illness-prediction, nsduh-mental-health, samhsa, smi-ami-estimation, statistical-modeling
Organization: U.S. Department of Health & Human Services
Table 23. Serious Mental Illness in the Past Year, by Age Group and State: Percentages, Annual Averages Based on 2010 and 2011 NSDUHs

This report presents State estimates for serious mental illness in the past year based on the combined 2010 and 2011 National Surveys on Drug Use and Health (NSDUHs). Resuts are provided by age group.

Tags: mental-health-statistics, nsduh, samhsa, serious-mental-illness, state-level-data
Organization: U.S. Department of Health & Human Services
2022 Uniform Reporting System (URS) Table For New York

This is the 2022 Uniform Reporting System (URS) Output Tables for New York. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-data, evidence-based-practices, mental-health-services, noms-measures, samhsa
Organization: U.S. Department of Health & Human Services
Table 16. Alcohol Dependence or Abuse in the Past Year, by Age Group and State: Percentages, Annual Averages Based on 2013 and 2014 NSDUHs

Table 16. Alcohol Dependence or Abuse in the Past Year, by Age Group and State: Percentages, Annual Averages Based on 2013 and 2014 NSDUHs

Tags: alcohol-abuse, alcohol-dependence, nsduh-data, samhsa, state-level-data
Organization: U.S. Department of Health & Human Services
Adults with Less Education Most Likely to Have a Past Year Anxiety Disorder

The spotlight is based on data from the National Survey on Drug Use and Health's (NSDUH's) Mental Health Surveillance Study (MHSS). It discusses people with one or more anxiety disorders by their education level.

Tags: anxiety-disorders, education-level, mental-health-surveillance, nsduh-mhss, samhsa
Organization: U.S. Department of Health & Human Services
2020 Uniform Reporting System (URS) Table For Illinois

This is the 2020 Uniform Reporting System (URS) Output Tables for Illinois. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-data, illinois, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
2013 NSDUH Incidence Tables  (Prevalence Estimates) - 4.1 to 4.16

These detailed tables present totals and prevalence estimates of substance use initiation from the 2013 National Survey on Drug Use and Health (NSDUH). Substances examined include illicit drugs (e.g., marijuana, cocaine, heroin, hallucinogens (including LSD, PCP, Ecstasy), inhalants, and the nonmedical use of prescription-type pain relievers (including OxyContin), tranquilizers, stimulants, sedatives, alcohol, and tobacco products (including cigarettes, smokeless tobacco, and cigars). Results are provided by age group and gender. Estimates are provided for both 2013 and 2012.

Tags: alcohol-tobacco, drug-prevalence, initiation-rates, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Region 8, Volume 6

This is a behavioral health report for HHS Region VIII of the United States and utilizes data from the National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment (N-SSATS), collected annually. The topics addressed in the reports include youth mental health, adult mental health, and substance use.

Tags: behavioral-health, mental-health, nsduh-data, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Apolipoprotein E gene polymorphism is not a strong risk factor for diabetic nephropathy and retinopathy in Type I diabetes: case-control study

Background
          The gene encoding apolipoprotein E (APOE) has been proposed as a candidate gene for vascular complications in Type I diabetes. This study aimed to investigate the influence of three-allelic variations in the APOE gene for the development of diabetic retinopathy and nephropathy.
        
        
          Results
          Neither APOE alleles frequencies or APOE genotypes frequencies differed between Type I diabetic groups either with or without nephropathy. Similar results were found for patients with and without diabetic retinopathy.
        
        
          Conclusions
          APOE gene polymorphism does not determine genetic susceptibility for the development of diabetic retinopathy in Type I diabetes patients. Association between APOE gene polymorphism and diabetic nephropathy may be weak or moderate, but not strong.

Tags: apoe-gene, diabetic-nephropathy, diabetic-retinopathy, nih, type-1-diabetes
Organization: U.S. Department of Health & Human Services
Weight loss maintenance in women two to eleven years after participating in a commercial program: a survey

Background
          After 5 years, most reports show that less than 10% of people maintain a 5% loss from initial body weight. Weight maintenance after 10 years is rarely assessed, especially in commercial programs. The current article reports weight maintenance in individuals who had participated 2 to 11 years earlier in a popular commercial weight loss program based on Canada's Food Guide called Mincavi.
        
        
          Methods
          Randomly picked subjects answered a telephone questionnaire. Participants, 291 adult women from various regions of the province of Quebec, had followed the program 2 to 11 years earlier for at least a month. Body weight at the beginning and at the end of treatment was recorded as well as actual weight, age and height. Existing records allowed partial verification of the sample.
        
        
          Results
          Based on corrected weights, percentage of women who maintained at least 5% of their initial weight loss are as following; 2 years = 43.6% (n = 55), 3 years = 33.3% (n = 42), 4 years = 23.8% (n = 42), 5–6 years = 38.2% (n = 55), 7–8 years = 29.4% (n = 51), and 9–11 years; 19.6% (n = 46). Five to eleven years after they had participated in the program 29.1% of all women maintained a weight loss of at least 5%, while 14.3% maintained a loss of at least 10%.
        
        
          Conclusions
          Even though success rate is not as high as could be wished for, results show that participation in the Mincavi program can lead to effective weight maintenance long after individuals have left it. These findings suggest more thorough studies should be conducted on this weight loss program.

Tags: commercial-weight-loss, longitudinal-study, nih, weight-loss-maintenance, womens-health
Organization: U.S. Department of Health & Human Services
2012 State Profile - West Virginia

This is a National Survey of Substance Abuse Treatment Services (N-SSATS) annual report showing the state profile for West Virginia in 2012. N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 States, the District of Columbia, and other U.S. jurisdictions.

Tags: n-ssats, samhsa, substance-abuse-treatment, treatment-facilities, west-virginia
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Region 1, Volume 6

This is a behavioral health report for HHS Region I of the United States and utilizes data from the National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment (N-SSATS), collected annually. The topics addressed in the reports include youth substance use, youth mental health and treatment, adult mental health, substance use and substance use treatment.

Tags: behavioral-health, mental-health, samhsa, substance-use, youth-mental-health
Organization: U.S. Department of Health & Human Services
Where is biological therapy going?

The substantial progress in our understanding of molecular and cellular biology has allowed us to design biological therapeutics ('biologicals') with defined targets and effector functions. These biologicals have greatly contributed to our current knowledge of pathogenetic mechanisms in autoimmune diseases. However, although some of the biologicals have been extremely successful in treating the symptoms of chronic inflammation, biological therapy has not yet met the expectations of permanently silencing the chonic immune response. In this commentary we discuss current concepts and future directions of biological therapy, and the potential usefulness of biologicals as a treatment of human autoimmune diseases in appropriate critical applications with the use of suitably designed agents.

Tags: autoimmune-diseases, biological-therapy, immunomodulation, monoclonal-antibodies, nih
Organization: U.S. Department of Health & Human Services
National Survey of Substance Abuse Treatment Services (N-SSATS): 2013 Data on Substance Abuse Treatment Facilities

This report presents results from the 2013 National Survey of Substance Abuse Treatment Services (N-SSATS), an annual census of facilities providing substance abuse treatment. Conducted by the Substance Abuse and Mental Health Services Administration (SAMHSA), the N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 states, the District of Columbia, and other U.S. jurisdictions

Tags: addiction-treatment, behavioral-health-services, samhsa, substance-abuse-treatment, treatment-facility-census
Organization: U.S. Department of Health & Human Services
A surrogate-based approach for post-genomic partner identification

Background
          Modern drug discovery is concerned with identification and validation of novel protein targets from among the 30,000 genes or more postulated to be present in the human genome. While protein-protein interactions may be central to many disease indications, it has been difficult to identify new chemical entities capable of regulating these interactions as either agonists or antagonists.
        
        
          Results
          In this paper, we show that peptide complements (or surrogates) derived from highly diverse random phage display libraries can be used for the identification of the expected natural biological partners for protein and non-protein targets. Our examples include surrogates isolated against both an extracellular secreted protein (TNFβ) and intracellular disease related mRNAs. In each case, surrogates binding to these targets were obtained and found to contain partner information embedded in their amino acid sequences. Furthermore, this information was able to identify the correct biological partners from large human genome databases by rapid and integrated computer based searches.
        
        
          Conclusions
          Modified versions of these surrogates should provide agents capable of modifying the activity of these targets and enable one to study their involvement in specific biological processes as a means of target validation for downstream drug discovery.

Tags: drug-discovery, nih, phage-display, protein-interactions, target-identification
Organization: U.S. Department of Health & Human Services
The adverse neuro-developmental effects of postnatal steroids in the preterm infant: a systematic review of RCTs

Background
          Recent reports have raised concerns that postnatal steroids may cause neuro-developmental impairment in preterm infants. This systematic review was performed with the objective of determining whether glucocorticoid therapy, to prevent or treat bronchopulmonary dysplasia, impairs neuro-developmental outcomes in preterm infants.
        
        
          Method
          A systematic review of the literature was performed. Medline was searched and articles retrieved using predefined criteria. Data from randomized controlled trials with adequate neuro-developmental follow up (to at least one year) were entered into a meta-analysis to determine the effects of postnatal treatment of preterm infants with glucocorticoids. Cerebral palsy rates, and neuro-developmental impairment (developmental score more than 2SD below the mean, or cerebral palsy or blindness) were analyzed. The studies were divided into 2 groups according to the extent of contamination of the results by treatment of controls with steroids after the initial study period, those with less than 30% contamination, and those with more than 30% contamination or size of contamination not reported.
        
        
          Results
          Postnatal steroid therapy is associated with an increase in cerebral palsy and neuro-developmental impairment. The studies with less contamination show a greater effect of the steroids, consistent with a real direct toxic effect of steroids on the developing central nervous system. The typical relative risk for the development of cerebral palsy derived from studies with less than 30% contamination is 2.86 (95% CI 1.95, 4.19). The typical relative risk for the development of neuro-developmental disability among followed up infants from studies with less than 30% contamination is 1.66 (95% CI 1.26, 2.19). From this subgroup of studies, the number of premature infants who need to be treated to have one more infant with cerebral palsy (number needed to harm, NNH) is 7; to have one more infant with neuro-developmental impairment the NNH is 11.
        
        
          Conclusions
          Postnatal pharmacologic steroid treatment for prevention or treatment of bronchopulmonary dysplasia is associated with dramatic increases in neuro-developmental impairment. As there is no clear evidence in the literature of long term benefit, their use for this indication should be abandoned.

Tags: cerebral-palsy, neurodevelopmental-outcomes, nih, postnatal-steroids, preterm-infants
Organization: U.S. Department of Health & Human Services
Within the fold: assessing differential expression measures and reproducibility in microarray assays

Fold-change' cutoffs have been widely used in microarray assays to identify genes that are differentially expressed. More accurate measures are required to identify high-confidence sets of genes with biologically meaningful changes in transcription. A general procedure for analyzing cDNA microarray data is proposed and validated. It is shown that pooled reference samples should be based not only on the expression of individual genes in each cell line but also on the expression levels of genes within cell lines.

Tags: cdna-microarray, differential-expression, gene-expression, microarray-analysis, nih
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Region 1, Volume 7

Explore state and regional data for HHS Region 1 with this user-friendly behavioral health report. It uses data from the 2021-2022 National Surveys on Drug Use and Health (NSDUH). The topics addressed in this report include substance use, substance use disorders, and mental health. Selected estimates are provided for adolescents aged 12 to 17, underage people aged 12 to 20, adults aged 18 or older, and the general population aged 12 or older. Statistical tests compare population percentages of (1) HHS region versus national estimates, (2) state versus national estimates, and (3) state versus HHS region estimates.

Tags: behavioral-health, mental-health, nsduh-data, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
2010 State Profile — Ohio

This state profile includes data from facilities in Ohio that reported to N-SSATS for the survey reference date March 31, 2010. Data were collected on the location, characteristics, services offered, and number of clients in treatment at alcohol and drug abuse treatment facilities (both public and private) in Ohio. In Ohio, 373 substance abuse treatment facilities were included in the 2010 N-SSATS, reporting that there were 35,763 clients in substance abuse treatment on March 31, 2010. The survey response rate in Ohio was 92.1%.

Tags: addiction-services, n-ssats, ohio, samhsa, substance-abuse-treatment
Organization: U.S. Department of Health & Human Services
Pro/con ethics debate: Should mechanical ventilation be continued to allow for progression to brain death so that organs can be donated?

Organ transplants continue to redefine medical frontiers. Unfortunately, current demand for organs far surpasses availability, waiting lists are long and many people die before the organ they desperately need becomes available. One proposed way to increase organ availability is to admit patients to the ICU with severe neurological injuries, for a trial of therapy. If the injury is irretrievable, discussions would then focus on extending ventilation for potential brain death/organ donation if a prior wish to donate is known or if the substitute decision maker consents. The following debate discusses the ethical dilemmas of waiting for brain death.

Tags: brain-death, mechanical-ventilation, medical-ethics, nih, organ-donation
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Georgia, 2013

This is a behavioral health report for the state of Georgia. It uses the  National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment Services (NSSATS) to address the topics of youth substance use , youth mental health and treatment, adult mental health and treatment, substance use, substance use treatment for the years 2008 to 2012.

Tags: adult-mental-health, georgia-behavioral-health, samhsa, substance-abuse-treatment, youth-substance-use
Organization: U.S. Department of Health & Human Services
Apolipoprotein C3 SstI polymorphism and triglyceride levels in Asian Indians

Background
          A close association between Sst I polymorphism in the 3' untranslated region of the apolipoproteinC3 (APOC3) gene and levels of plasma triglycerides (TG) had been reported by different investigators. Hypertriglyceridemia(HTG) is a known risk factor for coronary artery disease (CAD) in the context of Asian Indians. We conducted a study on the relationship between APOC3 SstI polymorphism (S1S1, S1S2 and S2S2 genotypes) and plasma TG levels in a group of 139 male healthy volunteers from Northern India.
        
        
          Methods
          DNA samples were analyzed by polymerase chain reaction (PCR) followed by SstI digestion. Digested PCR products were run on 3% agarose gel and visualized by ethidium bromide staining.
        
        
          Results
          Rare S2 allele was highly prevalent in our study population (0.313) as compared to the Caucasians (0.00–0.11). The genotypic distribution was in agreement with Hardy-Weinberg equilibrium. S2 allele was almost two times more prevalent in the HTG group (N = 34) as compared to NTG group (N = 105) (p = 0.001). Multiple logistic regression revealed S1S2 individuals had age-adjusted odds ratio of 2.43 (95%CI = 0.99–6.01, p = 0.054) and S2S2 had 9.9 (95%CI = 2.66–37.29, p = 0.0006) for developing HTG in comparison to S1S1 genotype.
        
        
          Conclusions
          Our study shows a significant association between rare S2 allele and HTG in Asian Indians.

Tags: apolipoprotein-c3, asian-indians, gene-polymorphism, nih, triglyceride-levels
Organization: U.S. Department of Health & Human Services
Compound 528510: Hexadecane, 3-undecyl

Chemical compound data from PubChem database. IUPAC Name: 12-ethylpentacosane. Molecular Formula: C27H56. Molecular Weight: 380.7. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Optimisation of transgene action at the post-transcriptional level: high quality parthenocarpic fruits in industrial tomatoes

Background
          Genetic engineering of parthenocarpy confers to horticultural plants the ability to produce fruits under environmental conditions that curtail fruit productivity and quality. The DefH9-iaaM transgene, whose predicted action is to confer auxin synthesis specifically in the placenta, ovules and derived tissues, has been shown to confer parthenocarpy to several plant species (tobacco, eggplant, tomato) and varieties.
        
        
          Results
          UC82 tomato plants, a typical cultivar used by the processing industry, transgenic for the DefH9-iaaM gene produce parthenocarpic fruits that are malformed. UC82 plants transgenic for the DefH9-RI-iaaM, a DefH9-iaaM derivative gene modified in its 5'ULR by replacing 53 nucleotides immediately upstream of the AUG initiation codon with an 87 nucleotides-long sequence derived from the rolA intron sequence, produce parthenocarpic fruits of high quality. In an in vitro translation system, the iaaM mRNA, modified in its 5'ULR is translated 3–4 times less efficiently than the original transcript. An optimal expressivity of parthenocarpy correlates with a reduced transgene mRNA steady state level in DefH9-RI-iaaM flower buds in comparison to DefH9-iaaM flower buds. Consistent with the known function of the iaaM gene, flower buds transgenic for the DefH9-RI-iaaM gene contain ten times more IAA than control untransformed flower buds, but five times less than DefH9-iaaM flower buds.
        
        
          Conclusions
          By using an auxin biosynthesis transgene downregulated at the post-transcriptional level, an optimal expressivity of parthenocarpy has been achieved in a genetic background not suitable for the original transgene. Thus, the method allows the generation of a wider range of expressivity of the desired trait in transgenic plants.

Tags: fruit-quality, nih, parthenocarpic-fruit, tomato-genetics, transgene-expression
Organization: U.S. Department of Health & Human Services