AndreaBozzo/ceres-open-data-index huggingface dataset:
Beta-2 adrenergic and glucocorticoid receptor agonists modulate ozone-induced pulmonary protein leakage and inflammation in healthy and adrenalectomized rats

We have previously shown that neuroendocrine activation leading to increased circulating stress hormones was necessary for mediating ozone-induced lung injury and inflammation since adrenalectomy rats were protected from these ozone effects. Because adrenalectomy is invasive and also eliminates circulating mineralocorticoids along with stress hormones, one cannot rule out their contribution in diminution of ozone-induced lung effects. The goal of this study was to evaluate if agonists of stress hormone receptors β2 adrenergic receptors and glucocorticoid receptors were able to restore ozone-induced lung injury, inflammation and innate immune cell trafficking in adrenalectomy rats, and exacerbate these effects in control rats with sham surgery. Here, we reconfirmed that the pulmonary and systemic effects of ozone inhalation, characterized by vascular leakage, neutrophilic inflammation, cytokine release in the lungs and peripheral vascular lymphopenia, were significantly diminished by adrenlectomy. The treatment with a combination of β2 adrenergic receptor and glucocorticoid receptor agonists (Clenbuterol and dexamethasone) was able to restore these ozone effects in AD rats, and further exacerbate ozone-induced lung protein leakage, inflammation and lymphopenia in sham surgery rats. It was also noted that clenbuterol plus dexamethasone itself caused injury and cytokine increases in the lung. Although a variety of β2 adrenergic receptor and glucocorticoid agonists have been widely used for the treatment of chronic lung diseases, β2 adrenergic receptor agonists have been shown to exacerbate lung inflammation in asthmatics and epidemiological studies have indicated exacerbation of lung inflammation in asthmatics during increased air pollution episodes. Even though high concentrations of agonists were used, our study provides a potential causal mechanistic link between activation of stress hormone receptors in mediation of air pollution health effects, and how these effects might be exacerbated in those receiving asthma therapy. 

This dataset is associated with the following publication:
Henriquez, A., S. Snow, M. Schladweiler, C. Miller, J. Dye, A. Ledbetter, J. Richards, M. Hargrove, W. Williams, and U. Kodavanti. Beta-2 adrenergic and glucocorticoid receptor agonists modulate ozone-induced pulmonary protein leakage and inflammation in healthy and adrenalectomized rats.   TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA,  166(2): 288-305, (2018).

Tags: adrenalectomy, adrenergic-receptor-agonist, broncho-dilators, glucocorticoid-receptor-agonist, neuroendocrine-stress-axes, ozone, steroids
Organization: U.S. Environmental Protection Agency
Pt-XR hyersensitivity data record

Dataset for figures included in associated publication. 

This dataset is associated with the following publication:
Lehmann, D., and W. Williams. Cross-reactivity between halogenated platinum salts in an immediate-type respiratory hypersensitivity model.   INHALATION TOXICOLOGY. Taylor & Francis, Inc., Philadelphia, PA, USA, 30(11-12): 472-481, (2019).

Tags: allergy, cross-reactivity, hypersenstivity, platinum
Organization: U.S. Environmental Protection Agency
WSON_Coweeta_Chen et al_2017

Datasets describing bulk and speciated water soluble organic nitrogen and carbon species in 24 hour high volume PM samples. 

This dataset is associated with the following publication:
Chen, X., X. Mingjie, M. Hays, E. Eric, D. Schwede, and J. Walker. Characterization of organic nitrogen in aerosols at a forest site in the southern Appalachian Mountains May 2018.   Atmospheric Chemistry and Physics. Copernicus Publications, Katlenburg-Lindau,  GERMANY, issue}: 6829-6846, (2018).

Tags: aerosol, bidirectional-flux, biomass-burning, deposition, micrometeorology, nitrogen, organic-carbon, organic-nitrogen, organosulfate, sulfur
Organization: U.S. Environmental Protection Agency
Herb species occurrence data across the US

This is a dataset of the abundance of herbaceous species across ~15,000 plots across the US, along with related site date (e.g. climate, soil pH, etc.). 

This dataset is associated with the following publication:
Clark, C., S. Simkin, E. Allen, W. Bowman, J. Belnap, M. Brooks, S. Collins, L. Geiser, F. Gilliam, S. Jovan, L. Pardo, B. Schultz, C. Stevens, K. Suding, H. Throop, and D. Waller. Differential vulnerability of 348 herbaceous species to atmospheric deposition of nitrogen and sulfur across the contiguous U.S..   Nature Plants. Nature Publishing Group, New York, NY, USA,  697-705, (2019).

Tags: aquatic-and-terrestrial-biodiversity, atmospheric-deposition, biodiversity, critical-loads, naaqs, native-plants, nox, plants, sox
Organization: U.S. Environmental Protection Agency
Risk Analysis 2017 paper Changsy et al

data and model results to create figure and tables in Changsy et al 2017 Risk Analysis paper. 

This dataset is associated with the following publication:
Chang, S.Y., W. Vizuete, M. Serre, L. Pradeepa Vennam, M. Omary, V. Isakov, M. Breen, and S. Arunachalam. Finely Resolved On‐Road PM2.5 and Estimated Premature Mortality in Central North Carolina.   RISK ANALYSIS. Blackwell Publishing, Malden, MA, USA, 37(12): 2420-2434, (2017).

Tags: air-pollution, dispersion-modeling, exposure, mobile-sources
Organization: U.S. Environmental Protection Agency
Avium Legionella and Structures

Concentrations of  Legionella pneumphila and Mycobacterium avium as measured by quantitative Polmerase chaine reaction. 

This dataset is associated with the following publication:
Donohue, M., D. King, S. Pfaller, and J. Mistry. The sporadic nature of Legionella pneumophila, Legionella pneumophila Sg1 and Mycobacterium avium occurrence within residences and office buildings across 36 states in the United States.   JOURNAL OF APPLIED MICROBIOLOGY. Blackwell Publishing, Malden, MA, USA, 126(5): 1568-1579, (2019).

Tags: legionella, mycobacterium, occurence, strutures
Organization: U.S. Environmental Protection Agency
Datasets used in RD-023418: Adverse Outcome Pathway-Driven Identification of Rat Hepatocarcinogens in Short-Term Assays

Datasets used in RD-023418: Adverse Outcome Pathway-Driven Identification of Rat Hepatocarcinogens in Short-Term Assays. 

This dataset is associated with the following publication:
Rooney, J., T. Hill, C. Qin, F. Sistare, and C. Corton. Adverse outcome pathway-driven identification of rat liver tumorigens in short-term assays.   TOXICOLOGY AND APPLIED PHARMACOLOGY. Academic Press Incorporated, Orlando, FL, USA, 356: 99-113, (2018).

Tags: cancer, cytotoxicity, gene-expression-omnibus-accession-numbers, genotoxicity, liver, microarray, nuclear-receptor, prediction, tg-gates, toxpi
Organization: U.S. Environmental Protection Agency
Mutagenicity Data of Water Extracts

The dataset contain the primary mutagenicity data.  It consists of the number of mutant colonies (called revertants) per petri plate at each dose of the water extract as used in the Salmonella (Ames) bacterial mutagenicity assay.  The dataset also shows graphically the dose-response curves constructed from the primary data, as well as a table showing the slopes of those curves, which are the mutagenic potencies of the water expressed as revertants/ml-equivalents. 

This dataset is associated with the following publication:
Berninger, J., D. Demarini, S. Warren, J. Simmons, V. Wilson, J. Conley, M. Armstrong, D. Kolpin, K. Kuivila, T. Reilly, K. Romanok, D. Villeneuve, and P. Bradley. Predictive Analysis Using Chemical-Gene Interaction Networks Consistent with Observed Endocrine Activity and Mutagenicity of U.S. Streams.   ENVIRONMENTAL SCIENCE & TECHNOLOGY. American Chemical Society, Washington, DC, USA, 53(15): 8611-8620, (2019).

Tags: ames-assay, chemical-gene-networks, mutagenicity, u-s-streams
Organization: U.S. Environmental Protection Agency
Denitrification rates across a temperate North Pacific estuary, Yaquina Bay, Oregon

The extent and temporal variability of denitrification activity was measured in Yaquina Bay, Oregon, over a year using sediment cores collected approximately monthly from August 2003 through August 31, 2004. Denitrification rates in sediments from a marine-dominated intertidal sand flat near the mouth of the estuary averaged 0.181 ±0.114 mmol m-2 d-1 whereas sediments in the estuary (5 stations) and river averaged 0.626 ±0.141 mmol m-2 d-1.   Sediment cores from all estuarine sites indicated denitrification activity throughout the year and were within the values reported for other temperate estuaries. Denitrification rates decreased with depth from 0.4 mmol m-2 d-1 in the upper 2 to 5 cm of sediment to 0.006 mmol m-2 d-1 at 28 cm sediment depth, indicating denitrification occurred primarily in the upper 5 cm. There was no relationship between denitrification rate and nitrate concentrations in the overlying water column (r2 = 0.16).  Denitrification rates were lowest in areas with low sediment carbon content, particularly in the sandy intertidal areas at the mouth of the estuary (r2 = 0.78). The results suggest that denitrification rates in this estuary were influenced primarily by the availability of organic carbon. 
The amount of nitrogen removed by denitrification was estimated to be 8.7 percent of the annual Yaquina River load for August 2003 through August 2004. The relatively low percent lost via denitrification may be due to high river discharge when the nitrogen load was greatest during winter storm events and dissolved nitrogen was exported directly from the estuary into the Pacific Ocean. Stable isotopes were used to investigate the carbon source. The carbon isotope data increased from -27 δ13C in the freshwater river to -21.5 δ13C at the seawater site, reflecting a typical change from terrestrial plant vegetation to phytoplankton carbon sources. Similar values for δ13C between suspended and benthic sediments indicated resuspension and mixing occurred during tidal inflow. 

This dataset is associated with the following publication:
Sigleo, A. Denitrification Rates Across a Temperate North Pacific Estuary, Yaquina Bay, Oregon.   Estuaries and Coasts. Estuarine Research Federation, Port Republic, MD, USA, 42(3): 655-664, (2019).

Tags: denitrification, estuaries, nitrate, nitrogen-and-co-pollutants, nitrogen-ctcle, nutrients, oregon-coast, yaquina-bay
Organization: U.S. Environmental Protection Agency
ARYS mobile monitoring data-50m

This is the post-processed mobile air monitoring data, with the methods described in the science journal publication. 

This dataset is associated with the following publication:
Brantley, H., G. Hagler, S. Herndon, P. Massoli, M. Bergin, and A. Russell. Characterization of Spatial Air Pollution Patterns Near a Large Railyard Area in Atlanta, Georgia.   International Journal of Environmental Research and Public Health. Molecular Diversity Preservation International, Basel,  SWITZERLAND, 16(4): 535, (2019).

Tags: air-quality, mobile-monitoring, near-source, rail-yard
Organization: U.S. Environmental Protection Agency
VOC Database and Supporting Data

Continuous PM2.5 and tVOC sensor data paired with coincidental RH and temp measurements. 

This dataset is associated with the following publication:
Clements, A., S. Reece, T. Conner, and R. Williams. Observed Data Quality Concerns Involving Low-Cost Air Sensors.   Atmospheric Environment: X. Elsevier B.V., Amsterdam,  NETHERLANDS, 3: 100034, (2019).

Tags: low-cost-sensor, pm2-5, tvocs
Organization: U.S. Environmental Protection Agency
National Inventory of Reactive Nitrogen

The effectiveness of management actions in reducing the release of excess nitrogen (N) to the environment is best assessed if N fluxes across air, land and water are regularly quantified at relevant scales.  This dataset contains comprehensive 2002, 2007, and 2012 inventories of inputs and non-hydrologic N losses along with fossil fuel emissions, food demand, and terrestrial N surpluses for all HUC-8 subbasins of the contiguous United States using peer-reviewed, publicly available datasets. 

Tags: atmospheric-deposition, crop-agriculture, fertilizer, national-ambient-air-quality-standards, nitrogen, nitrogen-deposition, water-quality, wildfires
Organization: U.S. Environmental Protection Agency
ToxRefDB version 2.0: Improved utility for predictive and retrospective toxicology analyses

ToxRefDB comprises information from over fifty years of in vivo toxicity data. The database includes information for over 1000 chemicals, and is being used as a primary source of data for evaluating efforts of the ToxCast program [4,5], as well as for numerous predictive and retrospective analyses. 

This dataset is associated with the following publication:
Watford, S., L. Pham, J. Wignall, R. Shin, M.T. Martin, and K. Friedman. ToxRefDB version 2.0: Improved utility for predictive and retrospective toxicology analyses.   REPRODUCTIVE TOXICOLOGY. Elsevier Science Ltd, New York, NY, USA, 89: 145-158, (2019).

Tags: actor
Organization: U.S. Environmental Protection Agency
No data

There is no dataset. 

This dataset is associated with the following publication:
Lutes, C., C. Holton, R. Truesdale, J. Zimmerman, and B. Schumacher. Key Design Elements of Building Pressure Cycling for Evaluating Vapor Intrusion—A Literature Review..   Groundwater Monitoring & Remediation. Wiley-Blackwell Publishing, Hoboken, NJ, USA, 39(1): 66-72, (2019).

Tags: indoor-air, remediation, vapor-intrusion
Organization: U.S. Environmental Protection Agency
Supporting data for Hill et al (doi:10.1093/toxsci/kfw195)

Tables, Figures, and Supplemental Materials. 

This dataset is associated with the following publication:
Hill III, T., M. Nelms, S. Edwards, M. Martin, R. Judson, C. Corton, and C. Wood. Negative Predictors of Carcinogenicity for Environmental Chemicals.   TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA,  155(1): 157-169, (2017).

Tags: carcinogenicity, chemical, pathology, predictive-value, testing
Organization: U.S. Environmental Protection Agency
alpha-pinene-derived organic coatings on acidic sulfate aerosol reduce secondary organic aerosol formation from isoprene in the eastern United States

EPA did not generate data as part of this work. This dataset is not publicly accessible because: I personally did not generate any new data in this study. It can be accessed through the following means: Via contact with corresponding author. Format: This study was led by the University of North Carolina at Chapel Hill and they plan to distribute through Mendeley Data. Data is not yet posted. 

This dataset is associated with the following publication:
Schmedding, R., M. Ma, Y. Zhang, S. Farrell, H. Pye, Y. Chen, C. Wang, Q. Rasool, S.H. Budisulistiorini, A. Ault, J. Surratt, and W. Vizuete. α-Pinene-Derived organic coatings on acidic sulfate aerosol impacts secondary organic aerosol formation from isoprene in a box model.   ATMOSPHERIC ENVIRONMENT. Elsevier Science Ltd, New York, NY, USA, 213: 456-462, (2019).

Tags: biogenic-voc, pm2-5, pm2-5-air-quality-modeling, semivolatile-organic-compounds-svocs, soa
Organization: U.S. Environmental Protection Agency
Predicting Estrogenicity of a Group of Substituted Phenols_IATA

Data are summarized in a two-dimensional data matrix that was developed for each substance for hazard characterization (Tables S1–S3). In the horizontal direction of the matrix, read-across of the target phenol to the source analogues was performed for the purpose of data-gap filling, whereas in the vertical direction, data from different streams (traditional and NAM) were compared and contrasted, to evaluate concordance of orthogonal approaches for evaluating potential estrogenicity. The greater the degree of agreement in orthogonal approaches for determining bioactivity, the greater the confidence one has in using the collective results of such NAMs in hazard characterization of the target phenol. 

This dataset is associated with the following publication:
Webster, F., M. Gagne, G. Patlewicz, P. Pradeep, N. Trefiak, R. Judson, and T. Barton-Maclaren. Predicting estrogen receptor activation by a group of substituted phenols: An integrated approach to testing and assessment case study.   REGULATORY TOXICOLOGY AND PHARMACOLOGY. Elsevier Science Ltd, New York, NY, USA, 106: 278-291, (2019).

Tags: 2_, 4-di-tert-butylphenol, 4-tert-butylphenol, actor, adminstered-equivalent-dose-aed, bioactivity-exposure-ratio-ber, endocrine-disruption, estrogen, iata, nam, octabenzone, read-across
Organization: U.S. Environmental Protection Agency
Wetlands and Watershed Nutrients: Dataset for Manuscript

The dataset includes information to make Figure 4 within the manuscript. 

This dataset is associated with the following publication:
Golden, H., A. Rajib, C. Lane, J. Christensen, Q. Wu, and S. Mengistu. Non-floodplain Wetlands Affect Watershed Nutrient Dynamics: A Critical Review.   ENVIRONMENTAL SCIENCE & TECHNOLOGY. American Chemical Society, Washington, DC, USA, 53(13): 7203-7214, (2019).

Tags: nitrogen, nutrients, phosphorus, watershed-models, watersheds, wetlands
Organization: U.S. Environmental Protection Agency
Exhaled Breath Aerosol Data for Paper and Plastic Mask Extracts

This dataset contains the raw data for the paper and plastic mask extracts. The data include the features identified in positive and negative modes, including the abundance of each feature in the mask samples. 

This dataset is associated with the following publication:
Wallace, M., J. Pleil, and M. Madden. Identifying organic compounds in exhaled breath aerosol: Non-invasive sampling from respirator surfaces and disposable hospital masks.   JOURNAL OF AEROSOL SCIENCE. Elsevier Science Ltd, New York, NY, USA, 137: 10544, (2019).

Tags: exhaled-breath-aerosol, immunochemistry, liquid-chromatography-mass-spectrometry, respiratory-masks
Organization: U.S. Environmental Protection Agency
PAH Published Dataset

PAH Published Dataset. 

This dataset is associated with the following publication:
Wallace, M., J. Pleil, D. Whitaker, and K. Oliver. Recovery and reactivity of polycyclic aromatic hydrocarbons collected on selected sorbent tubes and analyzed by thermal desorption-gas chromatography/mass spectrometry.   JOURNAL OF CHROMATOGRAPHY A. Elsevier Science Ltd, New York, NY, USA, 1602: 19-29, (2019).

Tags: carbograph, gas-chromatography-mass-spectrometry-gc-ms, polycyclic-aromatic-hydrocarbons-pahs, tenax, thermal-desorption-td, xro-440
Organization: U.S. Environmental Protection Agency
Sustainability Assessment of Agricultural Rainwater Harvesting: Evaluation of Innovative Crop Types and Irrigation Practices

Data provided for Figures and Tables in the manuscript. 

This dataset is associated with the following publication:
Ghimire, S., and J. Johnston. Sustainability assessment of agricultural rainwater harvesting: Evaluation of alternative crop types and irrigation practices.   PLoS ONE. Public Library of Science, San Francisco, CA, USA, 14(5): e0216452, (2019).

Tags: commercial-rainwater-harvesting, energy-intensity, life-cycle-assessment, municipal-water-supply
Organization: U.S. Environmental Protection Agency
Particulate matter, nitrogen oxides, ozone and select volatile organic compounds during a winter sampling period in Logan, Utah, USA

Particulate matter mass (PM), trace gaseous pollutants, select volatile organic compounds, and meteorology. 

This dataset is associated with the following publication:
Mukerjee, S., L. Smith, R. Long, W. Lonneman, S. Kaushik, M. Colon, K. Oliver, and D. Whitaker. Particulate matter, nitrogen oxides, ozone, and select volatile organic compounds during a winter sampling period in Logan, Utah, USA.   JOURNAL OF THE AIR & WASTE MANAGEMENT ASSOCIATION. Air & Waste Management Association, Pittsburgh, PA, USA, 69(6): 778-788, (2019).

Tags: logan, nitrogen-oxides, ozone, particulate-matter, utah, volatile-organic-compounds
Organization: U.S. Environmental Protection Agency
KC-TRAQS Methods and Measurements

Data collected during the Kansas City Transportation and Local-Scale Air
Quality Study (KC-TRAQS). 

This dataset is associated with the following publication:
Kimbrough, S., S. Krabbe, R. Baldauf, T. Barzyk, M. Brown, S. Brown, C. Croghan, M. Davis, P. Deshmukh, R. Duvall, S. Feinberg, V. Isakov, R. Logan, T. McArthur, and A. Shields. Characterizing Community Air Pollution Impacts Near Complex Sources: The Kansas City Transportation and Local-Scale Air Quality Study (KC-TRAQS).   Chemosensors. MDPI AG, Basel,  SWITZERLAND, 7(2): x, (2019).

Tags: black-carbon, kc-traqs, near-source, pm2-5, rail, sensors
Organization: U.S. Environmental Protection Agency
Rubbertown NGEM Demo Project paper 1 dataset

This dataset contains information used to develop the graphs contained in the journal article "Rubbertown Next Generation Demonstration Project"  It contains passive sampler data for one year and select SPod Fenceline senor and Gas Chromatograph data associated with two emissions events described in the paper. 

This dataset is associated with the following publication:
Thoma, E., I. George, R. Duvall, T. Wu, D. Whitaker, K. Oliver, S. Mukerjee, H. Brantley, J. Spann, T. Bell, N. CarltonCarew, P. Deshmukh, J. Cansler, T. Cousett, T. Wei, A. Cooley, K. Zimmerman, B. Dewitt, and B. Parris. Rubbertown Next Generation Emissions Measurements Demonstration Project June 2019.   International Journal of Environmental Research and Public Health. Molecular Diversity Preservation International, Basel,  SWITZERLAND, 16(11): 19, (2019).

Tags: 1-3-butadiene, auto-gc, fenceline-monitoring, fugitive-emission, gmap, hap, method-325, ngem, odor, spod, voc
Organization: U.S. Environmental Protection Agency
CitySpace Dataset

High frequency PM2.5 and meteorological data from a sensor network in the Memphis, TN geographic area. 

This dataset is associated with the following publication:
Feinberg, S., R. Williams, G. Hagler, J. Low, L. Smith, R. Brown, D. Garver, M. Davis, M. Morton, J. Schaefer, and J. Campbell. Examining spatiotemporal variability of urban particulate matter and application of high-time resolution data from a network of low-cost air pollution sensors.   ATMOSPHERIC ENVIRONMENT. Elsevier Science Ltd, New York, NY, USA, 213: 579-584, (2019).

Tags: cityspace, fine-particulate-matter, low-cost-sensor, memphis-tn
Organization: U.S. Environmental Protection Agency
Salmonella Mutagenicity Data from Wildfire Firefighter's Urine

The dataset is the raw and partially analyzed urinary mutagenicity data, which were generated by US EPA scientists at the US EPA/RTP.  The data consist of the number of mutant colonies (revertants) per petri plate at each dose of the organic extract of the urine.  These are accompanied by the positive and negative controls.  In addition, the data from each experiment have been partially analyzed by performing a linear regression of the data to generate a slope value (revertants/ml-equivalents of urine) as well as an r-squared value, which is a measure of how linear the line is (i.e., how close to a straight line the data are). 

This dataset is associated with the following publication:
Adetona, A., W.K. Martin, S. Warren, N. Hanley, O. Adetona, J.(. Zhang, C. Simpson, M. Paulsen, S. Rathbun, J. Wang, D. DeMarini, and L. Naeher. Urinary Mutagenicity as a Biomarker of Occupational Smoke Exposures of Wildland Firefighters Performing Prescribed Burns.   INHALATION TOXICOLOGY. Taylor & Francis, Inc., Philadelphia, PA, USA, 31(2): 73-87, (2019).

Tags: ames-assay, mutagenicity, prescribed-burn, salmonella, urinary-mutagenicity, wildfire
Organization: U.S. Environmental Protection Agency