AndreaBozzo/ceres-open-data-index huggingface dataset:
2008 Directory of U.S. Mental Health Facilities

This publication is a national directory of mental health treatment facilities for 2008. This directory lists federal, state, and local government facilities and private facilities that provide mental health treatment services. The information about each facility that appears in this directory was provided by that facility in response to the 2008 National Mental Health Services Survey (N-MHSS). The Substance Abuse and Mental Health Services Administration (SAMHSA) conducts the N-MHSS annually. The directory is ordered alphabetically by state, by city within each state, and by facility name within each city. This directory includes mental health treatment facilities for all U.S. states and territories.

Tags: behavioral-health, mental-health-facilities, mental-health-services, samhsa, treatment-directory
Organization: U.S. Department of Health & Human Services
National Directory of Drug and Alcohol Abuse Treatment Facilities - 1990

The National Directory of Drug and Alcohol Abuse Treatment Programs 1990 lists federal, state, local, and private facilities that provide substance abuse treatment services. The directory includes treatment facilities that are licensed, certified, or otherwise approved for inclusion in the directory by their state substance abuse agencies and that responded to the 1989 National Survey of Substance Abuse Treatment Services (N-SSATS). The information about each facility that appears in this directory was provided by that facility in response to the 1989 N-SSATS. The Substance Abuse and Mental Health Services Administration (SAMHSA) conducts the N-SSATS annually.

Tags: alcohol-abuse-treatment, n-ssats, samhsa, substance-abuse-treatment, treatment-facilities
Organization: U.S. Department of Health & Human Services
Florida Study of Professional for Safe Families (FSPSF), Waves 1-8

The Florida Study of Professionals for Safe Families (FSPSF) is a longitudinal study of Florida’s 
child welfare workforce. The primary focus of the study examines turnover and retention 
decisions among frontline workers. FSPSF project staff recruited all Child Protective 
Investigators and Dependency Case Managers in pre-service training between Sept. 1, 2015 and 
December 31, 2016 and 84% of eligible participants provided consent and baseline information 
(N = 1,500). Participants were followed during the study timeframe even if they left their child 
welfare positions. Workers were surveyed every six months for approximately 3.5 years 
focusing on individual, occupational, and organizational influences on child welfare employee 
retention. 
This statewide study examined worker personal characteristics (e.g., educational background, 
family history, self-esteem, etc.) worker experiences and responses (e.g., stress and burnout, 
work/family balance, social support, and coping, etc.), and organizational influences (e.g., 
organizational climate, supervisory practices, and caseload responsibilities etc.). Respondents 
were surveyed every 6-7 months with a core instrument and three in-depth substantive modules 
that were rotated during the data collection period. Modules included a focus on 
(1) supervision and organizational functioning (assessed at waves 2, 5, and 8); 
(2) work/family life balance (assessed at waves 3, 6 and 8); and 
(3) mental health (assessed at waves 4 and 7). 
Overall, 100% of child welfare administrative units across the state of Florida agreed to be part 
of the study. Individual response rates for each wave were also very high. Across all waves of 
data collection, response rates averaged 81% and ranged from 77% to 87%, and 62% (n = 929) 
of participants responded at every wave of data collection.


Documentation for the data includes:

Investigators: Dina J. Wilke, PhD, MSW
Florida State University Tallahassee, FL

Melissa Radey, PhD, MSSW, MA
Florida State University Tallahassee, FL

Lisa Magruder, PhD, MSW
Florida State University Tallahassee, FL

Tags: abuse, care, ndacan, policy, reporting
Organization: U.S. Department of Health & Human Services
Compound 525219: Chloromethyl 6-chloro-octanoate

Chemical compound data from PubChem database. IUPAC Name: chloromethyl 6-chlorooctanoate. Molecular Formula: C9H16Cl2O2. Molecular Weight: 227.12. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
National Survey of Substance Abuse Treatment Services (N-SSATS): 2009 Data on Substance Abuse Treatment Facilities

This report presents results from the 2009 National Survey of Substance Abuse Treatment Services (N-SSATS), an annual census of facilities providing substance abuse treatment. Conducted by the Substance Abuse and Mental Health Services Administration (SAMHSA), the N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 states, the District of Columbia, and other U.S. jurisdictions.

Tags: addiction-services, behavioral-health, samhsa, substance-abuse-treatment, treatment-facility-census
Organization: U.S. Department of Health & Human Services
2013 CMHS Uniform Reporting System (URS) Table for North Carolina

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Tables for North Carolina for 2013. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program.  State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, noms-measures, samhsa, urs-data
Organization: U.S. Department of Health & Human Services
Compound 527266: Pentanoic acid, 2-iodoethyl ester

Chemical compound data from PubChem database. IUPAC Name: 2-iodoethyl pentanoate. Molecular Formula: C7H13IO2. Molecular Weight: 256.08. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Physico-chemical characterisation and biological evaluation of 188-Rhenium colloids for radiosynovectomy

Background
          Radiosynovectomy is a type of radiotherapy used to relieve pain and inflammation from rheumatoid arthritis. In this study, 188-Rhenium (188Re) colloids were characterized by physical and biological methodologies. This was used to assess which parameters of the kit formulation would be the basis in the development of a more effective radiopharmaceutical for synovectomy. Intraarticular injection in knees of rabbits assessed cavity leakage of activity.
        
        
          Methods
          The physical characteristics of tin (Sn) and sulphur (S) colloids were determined to assess the formulation with suitable properties. Particles were grouped in three ranges for analyzing their distribution according to their number, volume and surface. The ideal particle size range was considered to be from 2 to 10 microns. Membrane filtration and laser diffraction characterization methodologies were used.
        
        
          Results
          While membrane filtration could give misleading data, laser diffraction proportions more reliable results. The Sn colloid showed a better distribution of particle volume and surface than S colloid, in the 2 to 10 microns range. The 188Re-Sn colloid was obtained with a radiochemical purity higher than 95% after 30 minutes of autoclaving. While Sn colloid kit stability was verified for 60 days, the 188Re-Sn preparation was stable in the first 24 hrs. No significant intrabatch variability (n = 3) was detected. Biodistribution and scintigraphic studies in rabbits after intraarticular injection showed relevant activity only in knee, being 90% at 48 hours.
        
        
          Conclusion
          The 188Re-Sn colloid is easy to prepare, is stable for 24 hours and shows minimal cavity leakage after intraarticular injection into rabbit knees, suggesting this radiotherapeutical agent has suitable physical properties for evaluation for joint treatment in humans.

Tags: intraarticular-injection, nih, radiosynovectomy, rhenium-188, rheumatoid-arthritis
Organization: U.S. Department of Health & Human Services
Miami - Dade Div: Drug-Related Emergency Department Visits, 2004-2011 - All Misuse and Abuse

Excel file with estimates, rates, relative standard errors, trends and confidence intervals for all drug-related emergency department (ED) visits involving drug misuse or abuse in the Miami metropolitan area, Dade division, covering 2004-2011. Drug misuse/abuse visits include the use of illicit drugs, nonmedical use of pharmaceuticals, underage drinking and visits where alcohol was combined with another drug.

Tags: drug-related-ed-visits, emergency-department-data, miami-dade-county, samhsa, substance-abuse-trends
Organization: U.S. Department of Health & Human Services
Cre reporter strains produced by targeted insertion of

Background
          Several Cre reporter strains of mice have been described, in which a lacZ gene is turned on in cells expressing Cre recombinase, as well as their daughter cells, following Cre-mediated excision of a loxP-flanked transcriptional "stop" sequence. These mice are useful for cell lineage tracing experiments as well as for monitoring the expression of Cre transgenes. The green fluorescent protein (GFP) and variants such as EYFP and ECFP offer an advantage over lacZ as a reporter, in that they can be easily visualized without recourse to the vital substrates required to visualize β-gal in living tissue.
        
        
          Results
          In view of the general utility of targeting the ubiquitously expressed ROSA26 locus, we constructed a generic ROSA26 targeting vector. We then generated two reporter lines of mice by inserting EYFP or ECFP cDNAs into the ROSA26 locus, preceded by a loxP-flanked stop sequence. These strains were tested by crossing them with transgenic strains expressing Cre in a ubiquitous (β-actin-Cre) or a cell-specific (Isl1-Cre and En1-Cre) pattern. The resulting EYFP or ECFP expression patterns indicated that the reporter strains function as faithful monitors of Cre activity.
        
        
          Conclusions
          In contrast to existing lacZ reporter lines, where lacZ expression cannot easily be detected in living tissue, the EYFP and ECFP reporter strains are useful for monitoring the expression of Cre and tracing the lineage of these cells and their descendants in cultured embryos or organs. The non-overlapping emission spectra of EYFP and ECFP make them ideal for double labeling studies in living tissues.

Tags: cell-lineage-tracing, cre-recombinase, nih, reporter-mice, rosa26-locus
Organization: U.S. Department of Health & Human Services
2012 CMHS Uniform Reporting System Output Tables

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2012. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: mental-health-services, national-outcome-measures, samhsa, state-mental-health, substance-abuse-mental-health
Organization: U.S. Department of Health & Human Services
2018 Uniform Reporting System (URS) Table for Federated States of Micronesia

This is the 2018 Uniform Reporting System (URS) Output Tables for Federated States of Micronesia. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: mental-health-services, micronesia, national-outcome-measures, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
The usefulness of information on HDL-cholesterol: potential pitfalls of conventional assumptions

Treatment decisions related to disease prevention are often based on two conventional and related assumptions. First, an intervention-induced change in a surrogate marker (such as high-density lipoprotein [HDL]-cholesterol) in the desired direction translates into health benefits (such as reduction in coronary events). Second, it is unimportant which interventions are used to alter surrogate markers, since an intervention benefit is independent of the means by which it is achieved. The scientific foundation for these assumptions has been questioned. In this commentary, the appropriateness of relying on low levels of HDL-cholesterol for treatment decisions is reviewed. The Veterans Affairs - HDL-Cholesterol Intervention Trial (VA-HIT) investigators recently reported that only 23% of the gemfibrozil-induced relative reduction in risk of coronary events observed in the trial could be explained by changes in HDL-cholesterol between baseline and the 1-year visit. Thus, 77% of the health benefit to the participants was unexplained. Other possible explanations are that gemfibrozil has multiple mechanisms of action, disease manifestations are multifactorial, and laboratory measurements of HDL-cholesterol are imprecise. The wisdom of relying on levels and changes in surrogate markers such as HDL-cholesterol to make decisions about treatment choices should questioned. It seems better to rely on direct evidence of health benefits and to prescribe specific interventions that have been shown to reduce mortality and morbidity. Since extrapolations based on surrogate markers may not be in patients' best interest, the practice of medicine ought to be evidence-based.

Tags: coronary-events, gemfibrozil-treatment, hdl-cholesterol, nih, va-hit-trial
Organization: U.S. Department of Health & Human Services
Compound 525244: N''-(3-nitro-phenyl)-N,N,N',N'-tetramethyl-guanidine

Chemical compound data from PubChem database. IUPAC Name: 1,1,3,3-tetramethyl-2-(3-nitrophenyl)guanidine. Molecular Formula: C11H16N4O2. Molecular Weight: 236.27. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2012 State Profile - Texas

This is a National Survey of Substance Abuse Treatment Services (N-SSATS) annual report showing the state profile for Texas in 2012. N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 States, the District of Columbia, and other U.S. jurisdictions.

Tags: n-ssats, samhsa, substance-abuse-treatment, texas, treatment-facilities
Organization: U.S. Department of Health & Human Services
Mutant loxP vectors for selectable marker recycle and conditional knock-outs

Background
          Gene disruption by targeted integration of transfected constructs becomes increasingly popular for studies of gene function. The chicken B cell line DT40 has been widely used as a model for gene knock-outs due to its high targeted integration activity. Disruption of multiple genes and complementation of the phenotypes is, however, restricted by the number of available selectable marker genes. It is therefore highly desirable to recycle the selectable markers using a site-specific recombination system like Cre/loxP.
        
        
          Results
          We constructed three plasmid vectors (neoR, puroR and bsr), which carry selectable marker genes flanked by two different mutant loxP sites. After stable transfection, the marker genes can be excised from the genome by transient induction of Cre recombinase expression. This excision converts the two mutant loxP sites to an inactive double-mutant loxP. Furthermore we constructed a versatile expression vector to clone cDNA expression cassettes between mutant loxP sites. This vector can also be used to design knock-out constructs in which the floxed marker gene is combined with a cDNA expression cassette. This construct enables gene knock-out and complementation in a single step. Gene expression can subsequently be terminated by the Cre mediated deletion of the cDNA expression cassette. This strategy is powerful for analyzing essential genes, whose disruption brings lethality to the mutant cell.
        
        
          Conclusions
          Mutant loxP vectors have been developed for the recycle of selectable markers and conditional gene knock-out approaches. As the marker and the cDNA expression cassettes are driven by the universally active and evolutionary conserved β-actin promoter, they can be used for the selection of stable transfectants in a wide range of cell lines.

Tags: cre-loxp-system, dt40-cell-line, gene-knockout, nih, selectable-marker-recycle
Organization: U.S. Department of Health & Human Services
Supporting Healthy Marriage Evaluation: Eight Sites within the United States, 2003-2013

The Supporting Healthy Marriage (SHM) evaluation was launched in 2003 to develop, to implement, and to test the effectiveness of a program aimed at strengthening low-income couples' marriages as one approach for supporting stable and nurturing family environments and parents' and children's well-being. The evaluation was led by MDRC and was sponsored by the Office of Planning, Research and Evaluation in the Administration for Children and Families, United States Department of Health and Human Services.The SHM program was a voluntary yearlong marriage education program for low-income married couples who had children or were expecting a child. The program provided a series of group workshops based on structured curricula designed to enhance couples' relationships; supplemental activities to build on workshop themes; and family support services to address participation barriers, connect families with other services, and reinforce curricular themes.

The study sample consists of 6,298 couples (12,596 adult sample members) who were expecting a child or had a child under 18 years old at the time of study entry. The sample consists primarily of low-to-modest income, married couples with diverse racial and ethnic backgrounds. In each family, one child was randomly selected to be the focus of any child-related measures gathered in the data collection activities. These children ranged from pre-birth to 14 years old at the time of enrollment in the study. Follow-up interviews were conducted at 12 and 30 months after baseline data collection. More detail is provided in the study documentation.

<b>Units of Response: </b>Low-income married couples with children

<b>Type of Data: </b>Evaluation

<b>Tribal Data: </b>No

<b>COVID-19 Data: </b>No

<b>Periodicity: </b>One-time

<b>SORN: </b>https://www.federalregister.gov/documents/2022/09/19/2022-20139/privacy-act-of-1974-system-of-records

<b>Data Use Agreement: </b>https://www.icpsr.umich.edu/rpxlogin

<b>Data Use Agreement Location: </b>https://www.childandfamilydataarchive.org/cfda/archives/cfda/studies/36852/datadocumentation

<b>Equity Indicators: </b>Sex 

<b>Granularity: </b>Household;Individual

<b>Spatial: </b>United States

<b>Geocoding: </b>Unavailable

Tags: research-and-evaluation
Organization: U.S. Department of Health & Human Services
Defining signal thresholds in DNA microarrays: exemplary application for invasive cancer

Background
          Genome-wide or application-targeted microarrays containing a subset of genes of interest have become widely used as a research tool with the prospect of diagnostic application. Intrinsic variability of microarray measurements poses a major problem in defining signal thresholds for absent/present or differentially expressed genes. Most strategies have used fold-change threshold values, but variability at low signal intensities may invalidate this approach and it does not provide information about false-positives and false negatives.
        
        
          Results
          We introduce a method to filter false-positives and false-negatives from DNA microarray experiments. This is achieved by evaluating a set of positive and negative controls by receiver operating characteristic (ROC) analysis. As an advantage of this approach, users may define thresholds on the basis of sensitivity and specificity considerations. The area under the ROC curve allows quality control of microarray hybridizations. This method has been applied to custom made microarrays developed for the analysis of invasive melanoma derived tumor cells. It demonstrated that ROC analysis yields a threshold with reduced missclassified genes in microarray experiments.
        
        
          Conclusions
          Provided that a set of appropriate positive and negative controls is included on the microarray, ROC analysis obviates the inherent problem of arbitrarily selecting threshold levels in microarray experiments. The proposed method is applicable to both custom made and commercially available DNA microarrays and will help to improve the reliability of predictions from DNA microarray experiments.

Tags: cancer-research, dna-microarrays, gene-expression, nih, roc-analysis
Organization: U.S. Department of Health & Human Services
Compound 528597: tert-Butyldimethylsilyl 4-((tert-butyldimethylsilyl)oxy)-3,5-dimethoxybenzoate

Chemical compound data from PubChem database. IUPAC Name: [tert-butyl(dimethyl)silyl] 4-[tert-butyl(dimethyl)silyl]oxy-3,5-dimethoxybenzoate. Molecular Formula: C21H38O5Si2. Molecular Weight: 426.7. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 528430: 1-Tetradecene, 6-butyl

Chemical compound data from PubChem database. IUPAC Name: 6-butyltetradec-1-ene. Molecular Formula: C18H36. Molecular Weight: 252.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Genetic epidemiology: Juvenile idiopathic arthritis genetics - What's new? What's next?

Studies have established the magnitude of the genetic basis of juvenile idiopathic arthritis (JIA). JIA is a complex genetic condition and the genes that influence susceptibility are actively being sought. A candidate gene approach is being used by several groups. MHC-, cytokine- and T-cell-related genes have all been positively associated with JIA. Here we review some of the latest genetic data, and discuss ways in which JIA genetic research might proceed.

Tags: candidate-gene-study, genetic-epidemiology, jia-genetics, juvenile-idiopathic-arthritis, nih
Organization: U.S. Department of Health & Human Services