AndreaBozzo/ceres-open-data-index huggingface dataset:
NSDUH 2022 Editing And Imputation Report

Learn about the editing and statistical imputation procedures that were applied to respondent data for the 2022 National Survey on Drug Use and Health (NSDUH). Logical editing resolves inconsistencies or ambiguous data based on a respondent’s answers to other questions in the survey. Statistical imputation uses mathematical techniques to assign values when they are missing in the data.Introductory Chapters:An introduction, including a discussion of changes from the 2021 to 2022 survey.A description of the procedures and general principles for editing the NSDUH data.A description of the general imputation procedures used in NSDUH.Remaining chapters are descriptions of the editing and imputation for the following types of variables:Front-end demographics.Back-end demographics.Substance use.Special drugs and substance use disorder.Additional substance use, including treatment and emerging issues.Substance use risk and protective factors.Physical and mental health.Roster variables.Income.Health insurance.Pair variables.

Tags: data-editing, data-imputation, nsduh-2022, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Compound 525171: Nonaeythylene glycol, monoallyl ether, acetate

Chemical compound data from PubChem database. IUPAC Name: 2-[2-[2-[2-[2-[2-[2-[2-(2-prop-2-enoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl acetate. Molecular Formula: C23H44O11. Molecular Weight: 496.6. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 527346: 16,20,24,28-Tetramethyl-hentriacontyl cyanide

Chemical compound data from PubChem database. IUPAC Name: 17,21,25,29-tetramethyltritriacontanenitrile. Molecular Formula: C37H73N. Molecular Weight: 532.0. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Plasma colloid osmotic pressure in healthy infants

Background
          The plasma colloid osmotic pressure (COP) plays a major role in transcapillary fluid balance. There is no information on plasma COP of healthy infants beyond the first post-natal week. The normal COP in healthy adult subjects (25 mmHg) is currently also applied as a reference value for healthy infants. This study was designed to test whether plasma COP values in healthy infants are the same as those in normal adults.
        
        
          Methods
          Plasma COP was measured in 37 male and female healthy infants from 1 to 11 months old. For this purpose, 1 ml blood was collected during the patient's regularly scheduled visit if the patient required any type of blood test for routine laboratory analyses.
        
        
          Results
          Plasma COP levels correlated slightly with increasing age from 1 to 9 months old (linear regression analysis; r2 = 0.1, P < 0.049). We found no correlation between plasma COP and body weight at the same age (r2 = 0.05, P = 0.155). The mean and standard deviation of COP in all infants was 25.1 ± 2.6 mmHg, which is almost identical to an average COP of 25 mmHg in healthy adult subjects. Arbitrary division of the infants into three different age groups (1–3 months [n = 11], 5–8 months [n = 13] and 9–11 months [n = 13]) showed an average increase of approximately 2 mmHg in COP of 9-month-old to 11-month-old infants, compared with 1-month-old to 3-month-old infants (one-way analysis of variance; P = 0.26). There was no gender difference in the COP level (unpaired t-test), with an average of 25.1 ± 2.4 mmHg in 19 male infants compared with 25.2 ± 2.9 in 18 female infants. The 95% confidence interval for COP in both male and female infants (n = 37) was between 24.3 to 26.0 mmHg, ranging from 19.5 to 30.3 mmHg, with a median value of 25.2 mmHg.
        
        
          Conclusions
          The data accept the null hypothesis that the COP range in infants younger than 1 year old is similar to those observed in adult subjects. Our observations, compared with previously reported neonatal COP values, suggest that there is a sharp increase in COP within the first months after birth.

Tags: colloid-osmotic-pressure, fluid-balance, infant-health, nih, plasma-cop
Organization: U.S. Department of Health & Human Services
2013 CMHS Uniform Reporting System (URS) Table for West Virginia

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Tables for West Virginia for 2013. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program.  State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: mental-health-services, noms-measures, samhsa, substance-abuse, west-virginia
Organization: U.S. Department of Health & Human Services
2010 CMHS Uniform Reporting System (URS) Output Tables for Virginia

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2010. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, national-outcome-measures, samhsa, substance-abuse-mental-health
Organization: U.S. Department of Health & Human Services
Compound 525391: 2,6-Dimethyl-3,5-dithiaheptane

Chemical compound data from PubChem database. IUPAC Name: 2-(propan-2-ylsulfanylmethylsulfanyl)propane. Molecular Formula: C7H16S2. Molecular Weight: 164.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
The thermal stability of the

We have investigated the thermal stability of the Fusarium solani pisi cutinase as a function of pH, in the range from pH 2–12. Its highest enzymatic activity coincides with the pH-range at which it displays its highest thermal stability. The unfolding of the enzyme as a function of pH was investigated by microcalorimetry. The ratio between the calorimetric enthalpy (ΔHcal) and the van't Hoff enthalpy (ΔHv) obtained, is far from unity, indicating that cutinase does not exhibit a simple two state unfolding behaviour. The role of pH on the electrostatic contribution to the thermal stability was assessed using TITRA. We propose a molecular interpretation for the pH-variation in enzymatic activity.

Tags: cutinase-activity, enzyme-stability, fusarium-solani, nih, protein-unfolding
Organization: U.S. Department of Health & Human Services
Intraoperative radiation therapy (IORT) for previously untreated malignant gliomas

Background
          Intraoperative radiation therapy (IORT) is one of the methods used to deliver a large single dose to the tumor tissue while reducing the exposure of normal surrounding tissue. However, the usefulness of intraoperative electron therapy for malignant gliomas has not been established.
        
        
          Methods
          During the period from 1987 to 1997, 32 patients with malignant gliomas were treated with IORT. The histological diagnoses were anaplastic astrocytoma in 11 patients and glioblastoma in 21 patients. Therapy consisted of surgical resection and intraoperative electron therapy using a dose of 12–15 Gy (median, 15 Gy). The patients later underwent postoperative external radiation therapy (EXRT) with a median total dose of 60 Gy. Each of the 32 patients treated with IORT was randomly matched with patients who had been treated with postoperative EXRT alone (control). Patients were matched according to histological grade, age, extent of tumor removal, and tumor location.
        
        
          Results
          In the anaplastic astrocytoma group, the one-, two- and five-year survival rates were 81%, 51% and 15%, respectively in the IORT patients and 54%, 43% and 21%, respectively in the control patients. In the glioblastoma group, one-, two- and five-year survival rates were 63%, 26% and 0%, respectively in the IORT patients and 70%, 18% and 6%, respectively in the control patients. There was no significant difference between survival rates in the IORT patients and control patients in either the anaplastic astrocytoma group or glioblastoma group.
        
        
          Conclusions
          IORT dose not improve survival of patients with malignant gliomas compared to that of patients who have received EXRT alone.

Tags: glioblastoma, intraoperative-radiation, malignant-glioma, nih, radiation-therapy
Organization: U.S. Department of Health & Human Services
Table 19. Illicit Drug Dependence or Abuse in the Past Year among Persons Aged 12 or Older, by State and Substate Regions: Percentages, Annual Averages Based on 2008, 2009, and 2010 NSDUHs

This table presents the 2008 to 2010 National Survey on Drug Use and Health (NSDUH) estimates of past year illicit drug dependence or abuse by those aged 12 or older by State and substate regions.

Tags: adolescent-health, drug-dependence, nsduh, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
B cells in rheumatoid arthritis

Normally the immune response is restricted to the peripheral secondary lymphoid organs. However, additional ectopic lymphoid tissue may develop at chronic sites of inflammation. In the synovium of rheumatoid arthritis patients the local production of proinflammatory cytokines seems to support the formation of a precisely structured microenvironment, which allows an antigen dependent immune response to take place. The analysis of the V-gene repertoire expressed in synovial B cells demonstrated that in the inflamed synovium a germinal centre reaction takes place. Antigen presented by a network of follicular dendritic cells may activate synovial B cells and support their differentiation into plasma cells secreting high affinity antibodies. The specificity of these antibodies remains to be determined.

Tags: autoantibodies, b-cells, nih, rheumatoid-arthritis, synovial-tissue
Organization: U.S. Department of Health & Human Services
Effects of microcosm scaling and food resources on growth and survival of larval

Background
          We used a simple experimental design to test for the effects of microcosm scaling on the growth and survival of the mosquito, Culex pipiens. Microcosm and mesocosm studies are commonly used in ecology, and there is often an assumption that scaling doesn't affect experimental outcomes. The assumption is implicit in the design; choice of mesocosms may be arbitrary or based on convenience or cost. We tested the hypothesis that scale would influence larvae due to depth and surface area effects. Larvae were predicted to perform poorly in microcosms that were both deep and had small openings, due to buildup of waste products, less exchange with the environment, and increased competition. To determine if the choice of scale affected responses to other factors, we independently varied leaf litter quantity, whose effects on mosquitoes are well known.
        
        
          Results
          We found adverse effects of both a lower wall surface area and lower horizontal surface area, but microcosm scale interacted with resources such that C. pipiens is affected by habitat size only when food resources are scarce. At low resource levels mosquitoes were fewer, but larger, in microcosms with smaller horizontal surface area and greater depth than in microcosms with greater horizontal surface area and shallower depth. Microcosms with more vertical surface area/volume often produced larger mosquitoes; more food may have been available since mosquitoes browse on walls and other substrates for food.
        
        
          Conclusions
          The interaction between habitat size and food abundance is consequential to aquatic animals, and choice of scale in experiments may affect results. Varying surface area and depth causes the scale effect, with small horizontal surface area and large depth decreasing matter exchange with the surrounding environment. In addition, fewer resources leads to less leaf surface area, and the effects of varying surface area will be greater under conditions of limiting resources. This leads to smaller size, which limits fecundity and survival. Choice of container size, either by ovipositing females or researchers, interacts with a major aspect of the ecology of animals; obtaining resources in a resource-limited environment.

Tags: culex-pipiens, environmental-factors, microcosm-study, mosquito-larvae, nih
Organization: U.S. Department of Health & Human Services
Brain dystrophin-glycoprotein complex: Persistent expression of beta-dystroglycan, impaired oligomerization of Dp71 and up-regulation of utrophins in animal models of muscular dystrophy

Background
          Aside from muscle, brain is also a major expression site for dystrophin, the protein whose abnormal expression is responsible for Duchenne muscular dystrophy. Cognitive impairments are frequently associated with this genetic disease, we therefore studied the fate of brain and skeletal muscle dystrophins and dystroglycans in dystrophic animal models.
        
        
          Results
          All dystrophin-associated glycoproteins investigated were reduced in dystrophic muscle fibres. In Dp427-deficient mdx brain and Dp71-deficient mdx-3cv brain, the expression of α-dystroglycan and laminin was reduced, utrophin isoforms were up-regulated and β-dystroglycan was not affected. Immunofluorescence localization of β-dystroglycan in comparison with glial, endothelial and neuronal cell markers revealed co-localization of von Willebrand factor with β-dystroglycan. Its expression at the endothelial-glial interface was preserved in dystrophin isoform-deficient brain from mdx and mdx-3cv mice. In addition, chemical crosslinking revealed that the Dp71 isoform exists in mdx brain predominantly as a monomer.
        
        
          Conclusions
          This suggests an association of β-dystroglycan with membranes at the vascular-glial interface in the forebrain. In contrast to dystrophic skeletal muscle fibres, dystrophin deficiency does not trigger a reduction of all dystroglycans in the brain, and utrophins may partially compensate for the lack of brain dystrophins. Abnormal oligomerization of the dystrophin isoform Dp71 might be involved in the pathophysiological mechanisms underlying abnormal brain functions.

Tags: animal-models, brain-dystrophin, dystroglycan, muscular-dystrophy, nih
Organization: U.S. Department of Health & Human Services
Table 14. Cigarette Use in the Past Month, by Age Group and State: Percentages, Annual Averages Based on 2013 and 2014 NSDUHs

Table 14. Cigarette Use in the Past Month, by Age Group and State: Percentages, Annual Averages Based on 2013 and 2014 NSDUHs

Tags: cigarette-use, samhsa, state-level-data, tobacco-use, youth-smoking
Organization: U.S. Department of Health & Human Services
Table 19. Illicit Drug Dependence in the Past Year, by Age Group and State: Percentages, Annual Averages Based on 2010 and 2011 NSDUHs

This report presents State estimates for measures of past year illicit drug dependence based on the combined 2010 and 2011 National Surveys on Drug Use and Health (NSDUHs). Resuts are provided by age group.

Tags: age-group-analysis, illicit-drug-dependence, nsduh-data, samhsa, substance-use-disorder
Organization: U.S. Department of Health & Human Services
2012 Uniform Reporting System (URS) Tables for California

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2012. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, national-outcome-measures, samhsa, substance-abuse-mental-health
Organization: U.S. Department of Health & Human Services
Understanding Adolescent Inhalant Use

This report uses 2015 NSDUH data to explore inhalant use in the United States among those aged 12 or older. The report then examines inhalant use among adolescents aged 12 to 17 and describes estimates by demographic and geographic characteristics.

Tags: adolescent-health, inhalant-use, nsduh-data, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
The potential of human regulatory T cells generated

Regulatory T cells prevent autoimmunity by suppressing the reactivity of potentially aggressive self-reactive T cells. Contact-dependent CD4+ CD25+ 'professional' suppressor cells and other cytokine-producing CD4+ and CD8+ T-cell subsets mediate this protective function. Evidence will be reviewed that T cells primed with transforming growth factor (TGF)-β expand rapidly following restimulation. Certain CD4+ T cells become contact-dependent suppressor cells and other CD4+ and CD8+ cells become cytokine-producing regulatory cells. This effect is dependent upon a sufficient amount of IL-2 in the microenvironment to overcome the suppressive effects of TGF-β. The adoptive transfer of these suppressor cells generated ex vivo can protect mice from developing chronic graft-versus-host disease with a lupus-like syndrome and alter the course of established disease. These data suggest that autologous T cells primed and expanded with TGF-β have the potential to be used as a therapy for patients with systemic lupus erythematosus and other chronic inflammatory diseases. This novel adoptive immunotherapy also has the potential to prevent the rejection of allogeneic transplants.

Tags: autoimmune-diseases, graft-versus-host-disease, lupus-like-syndrome, nih, regulatory-t-cells
Organization: U.S. Department of Health & Human Services
Compound 528484: Docosane, 7-ethyl

Chemical compound data from PubChem database. IUPAC Name: 7-ethyldocosane. Molecular Formula: C24H50. Molecular Weight: 338.7. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Massachusetts (MA)

This report presents estimates for measures of substance use and mental health based on the combined 2010 and 2011 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for Massachusetts for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: mental-health, nsduh-data, samhsa, serious-mental-illness, substance-use
Organization: U.S. Department of Health & Human Services
2019 National Directory of Mental Health Treatment Facilities

The National Directory of Mental Health Treatment Facilities - 2019 is a listing of federal, state, and local government facilities and private facilities that provide mental health treatment services. It includes treatment facilities that responded to the 2018 National Mental Health Services Survey (N-MHSS). The information about each facility that appears in this Directory was provided by that facility in response to the 2018 N-MHSS. The N-MHSS is conducted annually by the Substance Abuse and Mental Health Services Administration (SAMHSA).The Directory is ordered alphabetically by state, by city within each state, and by facility name within each city. Each facility listing includes codes that represent the services offered and other features of the facility, including codes that indicate services for hearing impaired and non-English-speaking clients. Codes are defined in a key shown on pages v-viii. Because the services offered by a particular facility may change over time, it is always a good idea to verify the information in this Directory when contacting a facility.The Directory is also available online in a searchable format with maps showing the location of each facility. Go tohttps://findtreatment.samhsa.gov. Since the online listing is updated regularly, more current information may be available there than in this Directory.

Tags: behavioral-health, facility-directory, mental-health-services, samhsa, treatment-facilities
Organization: U.S. Department of Health & Human Services
Minnesota 2016 Potential Areas for Addressing Service Gaps for Opioid Treatment

The purpose of the medication-assisted treatment (MAT) facility maps is to identify areas on a state-by-state basis that may be potentially underserved by existing treatment facilities. The maps are created with a methodology that seeks to include the highest potential need areas from individual counties so that county-level stakeholders are also informed. The maps are meant to be used as a tool for policy makers to determine potentially underserved areas—not as a definitive representation of these areas.

Tags: mat-access, minnesota-opioids, opioid-treatment, samhsa, service-gap-analysis
Organization: U.S. Department of Health & Human Services
The NSDUH Report: Smoking and Mental Illness

This report uses 2009 to 2011 National Survey on Drug Use and Health (NSDUH) to assess past month cigarette use and number of cigarettes smoked among persons aged 12 or older by whether they had past year any mental illness (AMI). Results are shown by age group, gender, and age group by gender.

Tags: ami-smoking, cigarette-use, nsduh-data, samhsa, smoking-mental-illness
Organization: U.S. Department of Health & Human Services
Compound 528349: 3,4-Dichloro-1-trimethylsilyloxybenzene

Chemical compound data from PubChem database. IUPAC Name: (3,4-dichlorophenoxy)-trimethylsilane. Molecular Formula: C9H12Cl2OSi. Molecular Weight: 235.18. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services