AndreaBozzo/ceres-open-data-index huggingface dataset:
Illinois (IL)

This report presents estimates for measures of substance use and mental health based on the combined 2010 and 2011 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for Illinois for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: illinois, mental-health, nsduh, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
CMV infection of liver transplant recipients: comparison of antigenemia and molecular biology assays

Background
          CMV is a major clinical problem in transplant recipients. Thus, it is important to use sensitive and specific diagnostic techniques to rapidly and accurately detect CMV infection and identify patients at risk of developing CMV disease. In the present study, CMV infection after liver transplantation was monitored retrospectively by two molecular biology assays - a quantitative PCR assay and a qualitative NASBA assay. The results were compared with those obtained by prospective pp65 antigenemia determinations.
        
        
          Materials and Methods
          87 consecutive samples from 10 liver transplanted patients were tested for CMV by pp65 antigenemia, and CMV monitor and NASBA pp67 mRNA assay.
        
        
          Results
          CMV infection was detected in all patients by antigenemia and CMV monitor, whereas NASBA assay identified only 8/10 patients with viremia. Furthermore, CMV infection was never detected earlier by molecular biology assays than by antigenemia. Only 5/10 patients with CMV infection developed CMV disease. Using a cut off value of 8 cells/50,000, antigenemia was found to be the assay that better identified patients at risk of developing CMV disease. However, the kinetics of the onset of infection detected by NASBA and CMV monitor seemed to have better identified patients at risk of developing CMV disease. Furthermore, before onset of disease, CMV pp67 mRNA was found to have similar or better negative and positive predictive values for the development of CMV disease.
        
        
          Conclusions
          The present data, suggests that the concomitant use of antigenemia and pp67 mRNA assay gives the best identification of patients at risk of developing CMV disease.

Tags: antigenemia-assay, cmv-infection, liver-transplant, molecular-biology, nih
Organization: U.S. Department of Health & Human Services
Plasma proteins in a standardised skin mini-erosion (I): permeability changes as a function of time

Background
          A standardised technique using a suction-induced mini-erosion that allows serial sampling of dermal interstitial fluid (IF) for 5 to 6 days has been described. In the present study, we studied permeability changes as a function of time.
        
        
          Methods
          We examined IF concentrations of total protein concentration and the concentration of insulin (6.6 kDa), prealbumin (55 kDa), albumin (66 kDa), transferrin (80 kDa), IgG (150 kDa) and alpha-2-macroglobulin (720 kDa) as a function of time, using an extraction pressure of 200 mmHg below atmospheric.
        
        
          Results
          At 0 h after forming the erosion, mean total IF protein content (relative to plasma) was 26 ± 13% (SD). For the individual proteins, the relative mean concentrations were 65 ± 36% for insulin, 48 ± 12% for albumin, 30 ± 19% for transferrin, 31 ± 15%for IgG and 19.5 ± 10% for alpha-2-macroglobulin. At 24 h, the total IF protein content was higher than at 0 h (56 ± 26% vs 26 ± 13%; p < 0.05, diff: 115%), as were some of the individual protein concentrations: prealbumin (50 ± 24 vs 25 ± 13%; p < 0.05), albumin (68 ± 21 vs 48 ± 12%; p < 0.05) and IgG (55 ± 30 vs 31 ± 15%; p = 0.05). ln the interval 24 h to 96 h the concentrations were relatively unchanged.
        
        
          Conclusions
          The results indicate that fluid sampled at 0 h after forming the erosion represents dermal IF before the full onset of inflammation. From 24 h onward, the sampled fluid reflects a steady state of increased permeability induced by inflammation. This technique is promising as a tool for clinically sampling substances that are freely distributed in the body and as a model for studying inflammation and vascular permeability.

Tags: interstitial-fluid, nih, plasma-proteins, protein-concentration, skin-permeability
Organization: U.S. Department of Health & Human Services
Raleigh-Durham-Cary, NC

This report presents combined 2005 to 2010 National Survey on Drug Use and Health (NSDUH) results for those aged 12 or older in the Raleigh-Durham-Cary, NC metro area. The report includes estimates of substance use disorder, major depressive episode, illicit drug use, marijuana use, cigarette use, binge alcohol use, and the nonmedical use of prescription-type pain relievers. Results are provided for the Raleigh-Durham-Cary metro area, North Carolina, and the U.S. overall.

Tags: major-depression, nsduh-data, raleigh-durham-cary, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
2019 Uniform Reporting System (URS) Table for Palau

These are the 2019 Uniform Reporting System (URS) Output Tables for Palau. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, national-outcome-measures, palau-mental-health, samhsa
Organization: U.S. Department of Health & Human Services
AFCARS Briefing: ANPRM and NPRM on Implementation

This is a brief presentation on the Advance Notice of Proposed Rulemaking (ANPRM) soliciting comments and Notice of Proposed Rulemaking (NPRM) proposing to provide an additional two fiscal years to comply with the AFCARS requirements in the December 2016 final rule that were published in the Federal Register on March 15, 2018.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: care, compliance, fiscal, foster, policy
Organization: U.S. Department of Health & Human Services
2018 Uniform Reporting System (URS) Table for Connecticut

This is the 2018 Uniform Reporting System (URS) Output Tables for Connecticut. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-program, community-mental-health, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
2022 Mental Health Client-Level Data (MH-CLD) Detailed Tables

The Annual Detailed Tables provide data on race, ethnicity, sex, and age of clients served. The MH-CLD data set can also observe these demographic categories across National Outcome Measures (NOMs) which include stability in housing/residential status, adult employment, and access to services/capacity. These tables provide a comprehensive set of national, subgroup, and state-level data on key characteristics of individuals receiving treatment in the 2022 reporting year along with their mental health diagnoses and co-occurring disorders.

Tags: client-level-data, co-occurring-disorders, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Compound 528506: Hexadecane, 3-nonyl

Chemical compound data from PubChem database. IUPAC Name: 10-ethyltricosane. Molecular Formula: C25H52. Molecular Weight: 352.7. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2016 Uniform Reporting System (URS) Table for Vermont

This is the 2016 Uniform Reporting System (URS) Output Tables for Vermont. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: mental-health-services, national-outcome-measures, samhsa, substance-abuse-treatment, vermont
Organization: U.S. Department of Health & Human Services
Vector algebra in the analysis of genome-wide expression data

Background
          Data from thousands of transcription-profiling experiments in organisms ranging from yeast to humans are now publicly available. How best to analyze these data remains an important challenge. A variety of tools have been used for this purpose, including hierarchical clustering, self-organizing maps and principal components analysis. In particular, concepts from vector algebra have proven useful in the study of genome-wide expression data.
        
        
          Results
          Here we present a framework based on vector algebra for the analysis of transcription profiles that is geometrically intuitive and computationally efficient. Concepts in vector algebra such as angles, magnitudes, subspaces, singular value decomposition, bases and projections have natural and powerful interpretations in the analysis of microarray data. Angles in particular offer a rigorous method of defining 'similarity' and are useful in evaluating the claims of a microarray-based study. We present a sample analysis of cells treated with rapamycin, an immunosuppressant whose effects have been extensively studied with microarrays. In addition, the algebraic concept of a basis for a space affords the opportunity to simplify data analysis and uncover a limited number of expression vectors to span the transcriptional range of cell behavior.
        
        
          Conclusions
          This framework represents a compact, powerful and scalable construction for analysis and computation. As the amount of microarray data in the public domain grows, these vector-based methods are relevant in determining statistical significance. These approaches are also well suited to extract biologically meaningful information in the analysis of signaling networks.

Tags: gene-expression, microarray-data, nih, transcription-profiling, vector-algebra
Organization: U.S. Department of Health & Human Services
Massachusetts: 2011-2012 NSDUH

This report presents Massachusetts\'s estimates for 25 measures of substance use and mental health based on the combined 2011 and 2012 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided by State and for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: massachusetts, mental-health, nsduh-data, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Interaction between mevalonate pathway and retinoic acid-induced
differentiation

All trans retinoic acid (ATRA) is a potent inducer of differentiation of HL-60 cell line. The pretreatment of the cells by compactin, a competitive inhibitor of 3-hydroxy-3-methylglutaryl (HMG) CoA reductase, during 24 hours, enhances the ATRA-induced cell differentiation. At 50 nM, the percentage of cell differentiation is 34.9% ± 2 and 73% ± 2.96 in the control and compactin-treated cells, respectively. The removal of compactin boosts the level of HMG-CoA reductase and therefore the biosynthesis of sterol and nonsterol isoprenoid compounds. The participation of sterol and nonsterol pathway was then investigated. The supply of an excess of cholesterol (up to 80 μg/ml of LDL) leads to a significant decrease of cell differentiation by ATRA from 78% ± 0.1 to 54% ± 2.8. A concomitant decrease of cell growth (51% ± 6.4) was observed. The pretreatment of cells by the geranylgeranyltransferase inhibitor (GGTI-298) has no effect on the cell differentiation process. By contrast, the farnesyltransferase inhibitors (FTI-II and FTI-277) completely abolish the ATRA-induced differentiation, thus confirming the involvement of farnesylated proteins in the differentiation mechanism.

Tags: atra-differentiation, compactin-inhibition, hl-60-cells, mevalonate-pathway, nih
Organization: U.S. Department of Health & Human Services
2015 CMHS Uniform Reporting System (URS) Table for Maryland

2015 Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for Maryland. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, outcome-measures, samhsa, urs-data
Organization: U.S. Department of Health & Human Services
Compound 527331: Methyl 2-[1-methyl-5-(4-methylbenzoyl)pyrrol-2-yl]propanoate

Chemical compound data from PubChem database. IUPAC Name: methyl 2-[1-methyl-5-(4-methylbenzoyl)pyrrol-2-yl]propanoate. Molecular Formula: C17H19NO3. Molecular Weight: 285.34. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Articular cartilage and changes in arthritis: Matrix degradation

While many proteases in articular cartilage have been described, current studies indicate that members of two families of metalloproteases – MMPs and the ADAMTSs – are responsible for the degradation of the major components of this tissue. Collagenases (MMPs) make the first cleavage in triple-helical collagen, allowing its further degradation by other proteases. Aggrecanases (ADAMTSs), in conjunction with other MMPs, degrade aggrecan, a component of the proteoglycan aggregate. Anti-neoepitope antibodies that recognize the cleavage products of collagen and aggrecan generated by these enzymes are now available and are being used to detect the sites of action and to quantitate degradation products.

Tags: articular-cartilage, matrix-degradation, nih, osteoarthritis, proteases
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Region 5, Volume 5

This is a behavioral health report for HHS Region V of the United States and utilizes data from the National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment (N-SSATS), collected annually. The topics addressed in the reports include youth mental health and treatment, adult mental health and treatment, and substance use treatment.

Tags: behavioral-health, mental-health, region-5, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Detroit: Drug-Related Emergency Department Visits, 2004-2011 - All Visits

Excel file with estimates, rates, relative standard errors, trends and confidence intervals for all drug-related emergency department (ED) visits in the Detroit metropolitan area, covering 2004-2011. File includes all drug-related ED visits that are reportable to DAWN without regard for the reason for the visit or the specific drugs involved. It includes visits involving all forms of drug misuse or abuse plus visits resulting from adverse reaction, accidental ingestion, suicide attempts, and visits where patients were seeking detoxification services. These estimates are useful for looking at overall levels of drug involvement in ED visits.File includes data for over 500 drugs, including illicit drugs, prescription and over-the-counter medications, dietary supplements, inhalants and alcohol.  Includes total visits, gender, age group, race/ethnicity, outcome of visit, drug combinations, number of drugs involved in visit, drug frequency, and drugs confirmed by toxicology.Additional detail is provided for illicit drugs, psychotherapeutic drugs, central nervous system (CNS) drugs, respiratory drugs and cardiovascular drugs.

Tags: detroit-dawn, drug-related-ed-visits, emergency-department-data, samhsa, substance-abuse-trends
Organization: U.S. Department of Health & Human Services
Compound 525370: tert-Butyl Isopropyl sulfide

Chemical compound data from PubChem database. IUPAC Name: 2-methyl-2-propan-2-ylsulfanylpropane. Molecular Formula: C7H16S. Molecular Weight: 132.27. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Research Article: Arthritis Research

Synovial fibroblasts (SFs) have become a major target for ex vivo gene transfer in rheumatoid arthritis (RA), but efficient transduction of RA-SFs still is a major problem. The low proliferation rate and heterogeneity of RA-SFs, together with their lack of highly specific surface receptors, have hampered a more extensive application of this technique. Improving transduction protocols with conventional viral vectors, therefore, as well as developing novel strategies, such as alternative target cells, and novel delivery systems constitute a major challenge. Recent progress in this field will lead to the achievement of high transgene expression, and will facilitate the use of gene transfer in human trials.

Tags: gene-transfer, nih, rheumatoid-arthritis, synovial-fibroblasts, viral-vectors
Organization: U.S. Department of Health & Human Services
Comparison of 2015-2016 and 2016-2017 NSDUH Population Percentages (50 States and the District of Columbia)

These tables compare 2015-2016 state-level estimates to 2016-2017 state-level estimates.

Tags: mental-health, nsduh, samhsa, state-level-data, substance-use
Organization: U.S. Department of Health & Human Services
2021 Uniform Reporting System (URS) Table For Virginia

This is the 2021 Uniform Reporting System (URS) Output Tables for Virginia. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-data, mental-health-services, national-outcome-measures, samhsa, virginia-mental-health
Organization: U.S. Department of Health & Human Services
Wolbachia: Evolutionary novelty in a rickettsial bacteria

Background
          Although closely related, the alpha-proteobacteria Wolbachia and the Rickettsiacae (Rickettsia and Ehrlichia), employ different evolutionary life history strategies. Wolbachia are obligate endocellular symbionts that infect an extraordinary host range and, in contrast to the infectious and pathogenic Rickettsia and Ehrlichia, profoundly influence host reproductive biology.
        
        
          Results
          Phylogenies of the Rickettsia, Ehrlichia, and Wolbachia were independently inferred from 16S rDNA sequences and GroEL amino acid sequences. Topologies inferred from both sets of sequence data were consistent with one another, and both indicate the genus Wolbachia shared a common ancestor most recently with Ehrlichia. These two genera are a sister group to the genus Rickettsia. Mapping biological properties onto this phylogeny reveals that manipulation of host reproduction, characteristic of Wolbachia strains, is a derived characteristic. This evolutionary novelty is accompanied by the loss of the ability to infect vertebrate hosts.
        
        
          Conclusions
          Because of the contrasting transmission strategies employed by each, Wolbachia is expected to maximize efficiency of vertical transmission, while Ehrlichia and Rickettsia will optimize horizontal transfer of infection. Wolbachia manipulation of host reproduction could thus be viewed as strategy employed by this bacterium to foster its own propagation via vertical transmission.

Tags: endosymbionts, nih, rickettsia, wolbachia
Organization: U.S. Department of Health & Human Services
Compound 525403: Isopropyl n-butyl disulphide

Chemical compound data from PubChem database. IUPAC Name: 1-(propan-2-yldisulfanyl)butane. Molecular Formula: C7H16S2. Molecular Weight: 164.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2013 CMHS Uniform Reporting System (URS) Table for Mississippi

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Tables for Mississippi for 2013. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program.  State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, mississippi, noms-measures, samhsa
Organization: U.S. Department of Health & Human Services
Inhibition of the MEK1/ERK pathway reduces arachidonic acid release independently of cPLA

Background
          The 85-kDa cytosolic phospholipase A2 (cPLA2) mediates arachidonic acid (AA) release in MDCK cells. Although calcium and mitogen-activated protein kinases regulate cPLA2, the correlation of cPLA2 translocation and phosphorylation with MAPK activation and AA release is unclear.
        
        
          Results
          MEK1 inhibition by U0126 inhibited AA release in response to ATP and ionomycin. This directly correlated with inhibition of ERK activation but not with phosphorylation of cPLA2 on Ser505, which was only partially inhibited by ERK inhibition. Inhibition of AA release by U0126 was still observed when stoichiometric phosphorylation of cPLA2 on Ser505 was maintained by activating p38 with anisomycin. Translocation kinetics of wild-type cPLA2 and cPLA2 containing S505A or S727A mutations to Golgi were similar in response to ATP and ionomycin and were not affected by U0126.
        
        
          Conclusions
          These results suggest that the ability of cPLA2 to hydrolyze membrane phospholipid is reduced by inhibition of the MEK1/ERK pathway and that the reduction in activity is independent of cPLA2 phosphorylation and translocation to membrane. The results also demonstrate that cPLA2 mutated at the phosphorylation sites Ser505 and Ser727 translocated with similar kinetic as wild-type cPLA2.

Tags: arachidonic-acid, cpla2-enzyme, mek-erk-pathway, nih, phosphorylation-regulation
Organization: U.S. Department of Health & Human Services