AndreaBozzo/ceres-open-data-index huggingface dataset:
The NSDUH Report: Recent Trends in Menthol Cigarette Use

This report uses 2004 to 2010 National Survey on Drug Use and Health (NSDUH) to assess past month menthol and nonmenthol cigarette use and past month menthol cigarette initiation among persons aged or older. Results are shown by year, gender, age group, and race/ethnicity.

Tags: cigarette-use, menthol-cigarettes, nsduh-data, samhsa, tobacco-initiation
Organization: U.S. Department of Health & Human Services
Table 10. Binge Alcohol Use in the Past Month, by Age Group and State: Percentages, Annual Averages Based on 2013 and 2014 NSDUHs

Table 10. Binge Alcohol Use in the Past Month, by Age Group and State: Percentages, Annual Averages Based on 2013 and 2014 NSDUHs

Tags: alcohol-use, binge-drinking, nsduh, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
Time Between TPR and Finalization 10/1/2001 - 9/30/2002

This report provides state-specific data from fiscal year [insert year] about the time between the termination of parental rights and the adoption finalization for public agency adoptions.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: adoption, data, fiscal, policy, reporting
Organization: U.S. Department of Health & Human Services
AFCARS Technical Bulletin #3 - Frequency Report

This TB provides information on how to interpret the Adoption and Foster Care Analysis and Reporting System (AFCARS) frequency report and how to install and execute the AFCARS Frequency Report Utility, Version 2.1.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: adoption, data, foster, policy, reporting
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Oklahoma, 2013

This is a behavioral health report for the state of Oklahoma. It uses the  National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment Services (NSSATS) to address the topics of youth substance use , youth mental health and treatment, adult mental health and treatment, substance use, substance use treatment for the years 2008 to 2012.

Tags: mental-health-oklahoma, oklahoma-behavioral-health, samhsa, substance-use-trends, youth-substance-use
Organization: U.S. Department of Health & Human Services
On the probability of cost-effectiveness using data from randomized clinical trials

Background
          Acceptability curves have been proposed for quantifying the probability that a treatment under investigation in a clinical trial is cost-effective. Various definitions and estimation methods have been proposed. Loosely speaking, all the definitions, Bayesian or otherwise, relate to the probability that the treatment under consideration is cost-effective as a function of the value placed on a unit of effectiveness. These definitions are, in fact, expressions of the certainty with which the current evidence would lead us to believe that the treatment under consideration is cost-effective, and are dependent on the amount of evidence (i.e. sample size).
        
        
          Methods
          An alternative for quantifying the probability that the treatment under consideration is cost-effective, which is independent of sample size, is proposed.
        
        
          Results
          Non-parametric methods are given for point and interval estimation. In addition, these methods provide a non-parametric estimator and confidence interval for the incremental cost-effectiveness ratio. An example is provided.
        
        
          Conclusions
          The proposed parameter for quantifying the probability that a new therapy is cost-effective is superior to the acceptability curve because it is not sample size dependent and because it can be interpreted as the proportion of patients who would benefit if given the new therapy. Non-parametric methods are used to estimate the parameter and its variance, providing the appropriate confidence intervals and test of hypothesis.

Tags: acceptability-curve, clinical-trials, cost-effectiveness, health-economics, nih
Organization: U.S. Department of Health & Human Services
Seattle

Data tables consisting of Excel files with estimates, rates, relative standard errors, trends and confidence intervals, covering 2004-2011, for drug-related emergency department visits for the Seattle Metropolitan Statistical Area. Tables are provided for 10 topics (\"analytic categories\") which are defined in the \"Guide to Drug Abuse Warning Trend Tables,\"  a separate document.   Each table includes data for over 500 drugs, including illicit drugs, prescription and over-the-counter medications, dietary supplements, inhalants and alcohol. Includes total visits, gender, age group, race/ethnicity, outcome of visit, drug combinations, number of drugs involved in visit, drug frequency, and drugs confirmed by toxicology. Additional detail is provided for illicit drugs, psychotherapeutic drugs, central nervous system (CNS) drugs, respiratory drugs and cardiovascular drugs.

Tags: drug-abuse-trends, drug-related-ed-visits, emergency-department-data, samhsa, seattle-msa
Organization: U.S. Department of Health & Human Services
House dust mite barrier bedding for childhood asthma: randomised placebo controlled trial in primary care [ISRCTN63308372]

Background
          The house dust mite is the most important environmental allergen implicated in the aetiology of childhood asthma in the UK. Dust mite barrier bedding is relatively inexpensive, convenient to use, and of proven effectiveness in reducing mattress house dust mite load, but no studies have evaluated its clinical effectiveness in the control of childhood asthma when dispensed in primary care. We therefore aimed to evaluate the effectiveness of house dust mite barrier bedding in children with asthma treated in primary care.
        
        
          Methods
          Pragmatic, randomised, double-blind, placebo controlled trial conducted in eight family practices in England. Forty-seven children aged 5 to 14 years with confirmed house dust mite sensitive asthma were randomised to receive six months treatment with either house dust mite barrier or placebo bedding. Peak expiratory flow was the main outcome measure of interest; secondary outcome measures included asthma symptom scores and asthma medication usage.
        
        
          Results
          No difference was noted in mean monthly peak expiratory flow, asthma symptom score, medication usage or asthma consultations, between children who received active bedding and those who received placebo bedding.
        
        
          Conclusions
          Treating house dust mite sensitive asthmatic children in primary care with house dust mite barrier bedding for six months failed to improve peak expiratory flow. Results strongly suggest that the intervention made no impact upon other clinical features of asthma.

Tags: barrier-bedding, childhood-asthma, dust-mite-allergy, nih, randomized-controlled-trial
Organization: U.S. Department of Health & Human Services
Study of Fathers' Involvement in Permanency Placement Planning and Child Welfare Casework (2004-2005)

Most foster children are not living with their fathers at the time they are removed from their homes. While in foster care these children may experience even less contact with their nonresident fathers. This study examined child welfare practices with respect to identifying, locating, and involving fathers of children in foster care including whether child support resources were used. Local agency caseworkers were interviewed by phone about nearly 2,000 foster children in four study states. The study found that nonresident fathers are not often involved in case planning and nearly half were never contacted by the child welfare agency. The study was conducted in four states, Arizona, Massachusetts, Minnesota, and Tennessee, using three methods of data collection-interviews with child welfare administrators, case-level data collection through interviews with caseworkers, and data linkage between child welfare and child support systems. Of the three components, only the case-level data collected through interviews with caseworkers was contributed to the Archive.  Investigators interviewed local agency caseworkers about particular cases between October 2004 and February 2005 to examine front-line practices related to nonresident fathers. Cases were selected from among children who had been in foster care for at least 3 months but no more than 36 months. Children in the sample were all in foster care for the first time (first placement episode), and the child welfare agency's records indicated that each of the children's biological fathers were alive but not living in the home from which the child was removed. Additionally, only one child per mother was eligible for the study. Data on 1,958 eligible cases (83% response rate) were collected through telephone interviews with 1,222 caseworkers. The nonresident fathers of the children sampled represent a varied group. While most caseworkers, at the time of the interview, knew the identity of the fathers of children in the study's sample (88%), paternity had not yet been established for over one-third of the total sample's children (37%). A comparison with mothers found that demographic characteristics of identified nonresident fathers are similar to those of the resident mothers though fathers are slightly older (36 vs. 32 years old, on average) and more likely to have been married at some point. As expected, caseworkers appear to know less about nonresident fathers. The percent of "don't know" responses is much higher for nonresident fathers than for similar questions about resident mothers.

Investigators: Urban Institute- Karin Malm, Robert Geen, and Timothy Triplett

Tags: abuse, care, ndacan, policy, reporting
Organization: U.S. Department of Health & Human Services
Tulsa, OK

This report presents combined 2005 to 2010 National Survey on Drug Use and Health (NSDUH) results for those aged 12 or older in the Tulsa, OK metro area. The report includes estimates of substance use disorder, major depressive episode, illicit drug use, marijuana use, cigarette use, binge alcohol use, and the nonmedical use of prescription-type pain relievers. Results are provided for the Tulsa metro area, Oklahoma, and the U.S. overall.

Tags: mental-health, nsduh-data, samhsa, substance-use, tulsa-metro
Organization: U.S. Department of Health & Human Services
Variation in red cell transfusion practice in the intensive care unit: a multicentre cohort study

Objectives:
          To determine the degree of interinstitutional transfusion practice variation and reasons why red cells are administered in critically ill patients.
        
        
          Study design:
          Multicentre cohort study combined with a cross-sectional survey of physicians requesting red cell transfusions for patients in the cohort.
        
        
          Study population:
          The cohort included 5298 consecutive patients admitted to six tertiary level intensive care units in addition to administering a survey to 223 physicians requesting red cell transfusions in these units.
        
        
          Measurements:
          Haemoglobin concentrations were collected, along with the number and reasons for red cell transfusions plus demographic, diagnostic, disease severity (APACHE II score), intensive care unit (ICU) mortality and lengths of stay in the ICU.
        
        
          Results:
          Twenty five per cent of the critically ill patients in the cohort study received red cell transfusions. The overall number of transfusions per patient-day in the ICU averaged 0.95 ± 1.39 and ranged from 0.82 ± 1.69 to 1.08 ± 1.27 between institutions (P < 0.001). Independent predictors of transfusion thresholds (pre-transfusion haemoglobin concentrations) included patient age, admission APACHE II score and the institution (P < 0.0001). A very significant institution effect (P < 0.0001) persisted even after multivariate adjustments for age, APACHE II score and within four diagnostic categories (cardiovascular disease, respiratory failure, major surgery and trauma) (P < 0.0001). The evaluation of transfusion practice using the bedside survey documented that 35% (202 of 576) of pre-transfusion haemoglobin concentrations were in the range of 95-105 g/l and 80% of the orders were for two packed cell units. The most frequent reasons for administering red cells were acute bleeding (35%) and the augmentation of O2 delivery (25%).
        
        
          Conclusions:
          There is significant institutional variation in critical care transfusion practice, many intensivists adhering to a 100g/l threshold, and opting to administer multiple units despite published guidelines to the contrary. There is a need for prospective studies to define optimal practice in the critically ill.

Tags: anemia-management, critical-care, icu-mortality, nih, red-cell-transfusion
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Pennsylvania, 2013

This is a behavioral health report for the state of Pennsylvania. It uses the  National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment Services (NSSATS) to address the topics of youth substance use , youth mental health and treatment, adult mental health and treatment, substance use, substance use treatment for the years 2008 to 2012.

Tags: behavioral-health, mental-health, pennsylvania, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Results from the 2010 National Survey on Drug Use and Health: Summary of National Findings and Detailed Tables

This page presents the annual national findings report and detailed tables from the 2010 National Survey on Drug Use and Health (NSDUH). The annual national findings report and the detailed tables include national estimates of rates of initiation and use of illicit drugs (e.g., marijuana, cocaine, heroin, hallucinogens, inhalants, and the nonmedical use of prescription-type pain relievers, tranquilizers, stimulants, and sedatives), alcohol, and tobacco products and rates of driving under the influence of drugs or alcohol. The the annual national findings report and detailed tables also covers substance use treatment need/receipt and youth risk and prevention measures. Results are provided for age group, gender, pregnancy status, race/ethnicity, education level, employment status, geographic area, parole/probation status. Comparisons are made between 2010 and 2002 to 2009.

Tags: alcohol-tobacco-use, drug-use-survey, mental-health, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Compound 525174: Octaethylene glycol, diacetate

Chemical compound data from PubChem database. IUPAC Name: 2-[2-[2-[2-[2-[2-[2-(2-acetyloxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl acetate. Molecular Formula: C20H38O11. Molecular Weight: 454.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 528347: Phenol, 2,5-dichloro, TMS

Chemical compound data from PubChem database. IUPAC Name: (2,5-dichlorophenoxy)-trimethylsilane. Molecular Formula: C9H12Cl2OSi. Molecular Weight: 235.18. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
CCWIS & Adoption Savings Presentation

This presentation offers instructions on completing the CB-496 Quarterly Financial Report for title IV-E agencies during and after the Comprehensive Child Welfare Information System (CCWIS) Transition Period and for Adoption Assistance.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: adoption, fiscal, instruction, policy, reporting
Organization: U.S. Department of Health & Human Services
Physical Abuse Treatment Outcome Project: Application of Parent-Child Interaction Therapy (PCIT) to Physically Abusive Parents

This project was a randomized clinical trial designed to test the efficacy and sufficiency of Parent-Child Interaction Therapy (PCIT) in preventing re-reports of physical abuse among physically abusive parents entering the child welfare system.  One hundred ten physically abusive parents and their abused children were randomly assigned to one of three intervention conditions:  1) A modified PCIT-based parenting program, 2) The same modified PCIT-based program plus individualized wrap-around services, and 3) a community parenting group program that is representative of current standard care in the field.  Pre- and post-test measures of the family were taken.  Areas of assessment included depression, severity of abuse and neglect, internalizing and externalizing problem behaviors, child abuse potential, parent drug and alcohol disorders, parent-child interaction, parent and child intelligence, child’s perception of parent behaviors, and parent’s willingness to change behavior.  A demographics questionnaire was also administered and a review of child maltreatment reports was conducted.

Investigators: Mark Chaffin, Ph.D.

University of Oklahoma Health Sciences Center, Oklahoma City, OK

Tags: abuse, care, ndacan, policy, reporting
Organization: U.S. Department of Health & Human Services
A new non-linear normalization method for reducing variability in DNA microarray experiments

A simple and robust non-linear method is presented for normalization using array signal distribution analysis and cubic splines. Both the regression and spline-based methods described performed better than existing linear methods when assessed on the variability of replicate arrays

Tags: cubic-splines, data-normalization, dna-microarray, nih, variability-reduction
Organization: U.S. Department of Health & Human Services
Vasopressin-dependent flank marking in golden hamsters is suppressed by drugs used in the treatment of obsessive-compulsive disorder

Background
          Alterations in arginine vasopressin regulation and secretion have been proposed as one possible biochemical abnormality in patients with obsessive-compulsive disorder. In golden hamsters, arginine vasopressin microinjections into the anterior hypothalamus trigger robust grooming and flank marking, a stereotyped scent marking behaviors. The intensity and repetition of the behaviors induced by arginine vasopressin is somewhat reminiscent of Obsessive Compulsive Disorder in humans. The present experiments were carried out to test whether pharmacological agents used to alleviate obsessive compulsive disorder could inhibit arginine vasopressin-induced flank marking and grooming.
        
        
          Results
          Male golden hamsters were treated daily for two weeks with either vehicle, fluoxetine, clomipramine, or desipramine (an ineffective drug), before being tested for arginine vasopressin-induced flank marking and grooming. Flank marking was significantly inhibited in animals treated with fluoxetine or clomipramine but unaffected by treatment with desipramine. Grooming behavior was not affected by any treatment.
        
        
          Conclusion
          These data suggest that arginine vasopressin-induced flank marking may serve as an animal model for screening drugs used in the control of Obsessive Compulsive Disorder.

Tags: arginine-vasopressin, flank-marking, grooming-behavior, nih, obsessive-compulsive-disorder
Organization: U.S. Department of Health & Human Services
Compound 528459: 1-Pentadecene, 9-methyl

Chemical compound data from PubChem database. IUPAC Name: 9-methylpentadec-1-ene. Molecular Formula: C16H32. Molecular Weight: 224.42. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Low-molecular-weight heparins in the treatment of venous thromboembolism

Venous thromboembolism is a common disease that is associated with considerable morbidity if left untreated. Recently, low-molecular-weight heparins (LMWHs) have been evaluated for use in acute treatment of deep venous thrombosis and pulmonary embolism. Randomized studies have shown that LMWHs are as effective as unfractionated heparin in the prevention of recurrent venous thromboembolism, and are as safe with respect to the occurrence of major bleeding. A pooled analysis did not show substantial differences among different LMWH compounds used, but no direct comparison of the different LMWHs is currently available. Finally, in patients with pulmonary embolism, there is a relative lack of large studies of daily practice. It could be argued that large prospective studies, in patients who were treated with LMWHs from the moment of diagnosis, are needed.

Tags: deep-vein-thrombosis, low-molecular-weight-heparins, nih, pulmonary-embolism, venous-thromboembolism
Organization: U.S. Department of Health & Human Services
Risk factors for hospitalization among adults with asthma: the influence of sociodemographic factors and asthma severity

Background
          The morbidity and mortality from asthma have markedly increased since the late 1970s. The hospitalization rate, an important marker of asthma severity, remains substantial.
        
        
          Methods
          In adults with health care access, we prospectively studied 242 with asthma, aged 18–50 years, recruited from a random sample of allergy and pulmonary physician practices in Northern California to identify risk factors for subsequent hospitalization.
        
        
          Results
          Thirty-nine subjects (16%) reported hospitalization for asthma during the 18-month follow-up period. On controlling for asthma severity in multiple logistic regression analysis, non-white race (odds ratio [OR], 3.1; 95% confidence interval [CI], 1.1–8.8) and lower income (OR, 1.1 per $10,000 decrement; 95% CI, 0.9–1.3) were associated with a higher risk of asthma hospitalization. The severity-of-asthma score (OR, 3.4 per 5 points; 95%, CI 1.7–6.8) and recent asthma hospitalization (OR, 8.3; 95%, CI, 2.1–33.4) were also related to higher risk, after adjusting for demographic characteristics. Reliance on emergency department services for urgent asthma care was also associated with a greater likelihood of hospitalization (OR, 3.2; 95% CI, 1.0–9.8). In multivariate analysis not controlling for asthma severity, low income was even more strongly related to hospitalization (OR, 1.2 per $10,000 decrement; 95% CI, 1.02–1.4).
        
        
          Conclusion
          In adult asthmatics with access to health care, non-white race, low income, and greater asthma severity were associated with a higher risk of hospitalization. Targeted interventions applied to high-risk asthma patients may reduce asthma morbidity and mortality.

Tags: asthma-hospitalization, asthma-risk-factors, asthma-severity, nih, sociodemographic-factors
Organization: U.S. Department of Health & Human Services
Compound 528565: gamma-Resorcylic acid, TBDMS

Chemical compound data from PubChem database. IUPAC Name: [tert-butyl(dimethyl)silyl] 2,6-bis[[tert-butyl(dimethyl)silyl]oxy]benzoate. Molecular Formula: C25H48O4Si3. Molecular Weight: 496.9. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services