AndreaBozzo/ceres-open-data-index huggingface dataset:
Compound 525222: Methyl undecyl terephthalate

Chemical compound data from PubChem database. IUPAC Name: 1-O-methyl 4-O-undecyl benzene-1,4-dicarboxylate. Molecular Formula: C20H30O4. Molecular Weight: 334.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Emergency Department Visits Involving Methamphetamine: 2007 to 2011

This short report uses data on drug-related emergency department (ED) visits from the Drug Abuse Warning Network to examine the trends in ED visits involving methamphetamine from 2007 to 2011.  In addition to the trends for total methamphetamine-related visits, it also shows trends by gender and by age group; the age distribution of patients; the drugs most commonly combined with methamphetamine; and the outcome of the ED visits.

Tags: dawg-network, drug-related-visits, emergency-department, methamphetamine-abuse, samhsa
Organization: U.S. Department of Health & Human Services
Racial/Ethnic Differences in Mental Health Service Use among Adults

This chartbook uses combined 2008 to 2012 data from the National Survey on Drug Use and Health (NSDUH) to presentnationally representative estimates of mental health service utilization among adults aged 18 or older within different racial/ethnicgroups in the United States. Data on racial/ethnic differences in mental health service utilization also are examined inthe context of other characteristics, such as age, gender, marital status, employment status, poverty status, insurance status, overall health, substance use disorder status, and education.

Tags: adult-mental-health, mental-health-services, nsduh-data, racial-ethnic-disparities, samhsa
Organization: U.S. Department of Health & Human Services
Responding to Human Trafficking among Children and Youth in Foster Care and Missing from Foster Care

This joint Information Memorandum (IM) from the Administration on Children, Youth, and Families (ACYF); Children’s Bureau (CB); Family and Youth Services Bureau (FYSB); and the Office on Trafficking in Persons (OTIP) within the Administration for Children and Families (ACF) at the U.S. Department of Health and Human Services (HHS) provides an overview of federal statutes related to human trafficking among children and youth in the child welfare system and highlights resources to meet those requirements.

ACF-IM-22-01 (PDF)

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: care, foster, guidance, policy, regulation
Organization: U.S. Department of Health & Human Services
2017 Uniform Reporting System (URS) Table for Arkansas

This is the 2017 Uniform Reporting System (URS) Output Tables for Arkansas. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: arkansas, mental-health-services, national-outcome-measures, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
Compound 525602: N,N-Dimethyl-N'-(4-methylphenyl)-benzamidine

Chemical compound data from PubChem database. IUPAC Name: N,N-dimethyl-N'-(4-methylphenyl)benzenecarboximidamide. Molecular Formula: C16H18N2. Molecular Weight: 238.33. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 525480: 4-Methyl-3-thia-1-hexene

Chemical compound data from PubChem database. IUPAC Name: 2-ethenylsulfanylbutane. Molecular Formula: C6H12S. Molecular Weight: 116.23. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2010 CMHS Uniform Reporting System (URS) Output Tables for North Carolina

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2010. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-data, mental-health-services, noms-measures, samhsa, utilization-measures
Organization: U.S. Department of Health & Human Services
2012 State Profile - Maryland

This is a National Survey of Substance Abuse Treatment Services (N-SSATS) annual report showing the state profile for Maryland in 2012. N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 States, the District of Columbia, and other U.S. jurisdictions.

Tags: behavioral-health-services, maryland, n-ssats, samhsa, substance-abuse-treatment
Organization: U.S. Department of Health & Human Services
Chicago: Drug-Related Emergency Department Visits, 2004-2011 - Suicide Attempts

Excel file with estimates, rates, relative standard errors, trends and confidence intervals for all drug-related emergency department (ED) visits involving suicide attempts in the Chicago metropolitan area, covering 2004-2011.  Drug-related suicide attempts include visits for drug overdoses and for suicide attempts by other means (e.g., using a firearm) if drugs were involved or related to the suicide attempt.

Tags: chicago-metro, drug-overdose, emergency-department, samhsa, suicide-attempts
Organization: U.S. Department of Health & Human Services
2020 NSDUH Annual National Report

Read key findings from the 2020 National Survey on Drug Use and Health (NSDUH) on substance use, mental health, and treatment by age group. Metrics in the report cover the civilian, noninstitutionalized US population ages 12 and older. Unlike other NSDUH Annual National Reports, the 2020 report has no comparisons to the previous year, because changes in survey methodology mean the indicators are not comparable to past NSDUH estimates.Along with the full report, a set of slides is available that displays figures from the report. An errata document with corrected information was added in January 2023.

Tags: behavioral-health, mental-health, national-survey, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Region 3, Volume 5

This is a behavioral health report for HHS Region III of the United States and utilizes data from the National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment (N-SSATS), collected annually. The topics addressed in the reports include youth substance use, adult mental health and treatment, and substance use treatment.

Tags: behavioral-health, hhs-region-3, mental-health, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: North Dakota, 2013

This is a behavioral health report for the state of North Dakota. It uses the  National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment Services (NSSATS) to address the topics of youth substance use , youth mental health and treatment, adult mental health and treatment, substance use, substance use treatment for the years 2008 to 2012.

Tags: behavioral-health, mental-health, north-dakota, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Estrogen protects against the synergistic toxicity by HIV proteins, methamphetamine and cocaine

Background
          Human immunodeficiency virus (HIV) infection continues to increase at alarming rates in drug abusers, especially in women. Drugs of abuse can cause long-lasting damage to the brain and HIV infection frequently leads to a dementing illness.To determine how these drugs interact with HIV to cause CNS damage, we used an in vitro human neuronal culture characterized for the presence of dopaminergic receptors, transporters and estrogen receptors. We determined the combined effects of dopaminergic drugs, methamphetamine, or cocaine with neurotoxic HIV proteins, gp120 and Tat.
        
        
          Results
          Acute exposure to these substances resulted in synergistic neurotoxic responses as measured by changes in mitochondrial membrane potential and neuronal cell death. Neurotoxicity occurred in a sub-population of neurons. Importantly, the presence of 17beta-estradiol prevented these synergistic neurotoxicities and the neuroprotective effects were partly mediated by estrogen receptors.
        
        
          Conclusion
          Our observations suggest that methamphetamine and cocaine may affect the course of HIV dementia, and additionally suggest that estrogens modify the HIV-drug interactions.

Tags: estrogen-neuroprotection, hiv-neurotoxicity, methamphetamine-cocaine, neuronal-cell-death, nih
Organization: U.S. Department of Health & Human Services
Analysis of fluorescently labeled substance P analogs: binding, imaging and receptor activation

Background
          Substance P (SP) is a peptide neurotransmitter found in central and peripheral nerves. SP is involved in the control of smooth muscle, inflammation and nociception. The amino acid sequence of SP is Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2. Five different forms of fluorescently labeled SP have recently been synthesized, in which Alexa 488, BODIPY Fl, fluorescein, Oregon Green 488 or tetramethylrhodamine has been covalently linked to SP at Lys3. Here, these novel analogs are characterized as to their ligand binding, receptor activation and fluorescence labeling properties.
        
        
          Results
          Competition binding studies, using radiolabeled [125I] SP, revealed that all of the labeled forms of SP, except for Alexa 488-SP, effectively competed with radiolabeled SP for binding at the rat SP receptor. With the exception of Alexa 488-SP, all of the SP analogs produced Ca++ elevations and fluorescence labeling of the SP receptor expressed in Chinese hamster ovary cells. In SP-responsive neurons, BODIPY Fl-SP and Oregon Green 488-SP were as effective as unlabeled SP in producing a reduction of the M-type K+ current. Fluorescein-SP produced variable results, while tetramethylrhodamine-SP was less potent and Alexa 488-SP was less effective on intact neurons.
        
        
          Conclusions
          The above results show that fluorescent labeling of SP altered the biological activity and the binding properties of the parent peptide. Oregon Green 488 and BODIPY FL-SP are the most useful fluorophores for labeling SP without affecting its biological activity. Given these results, these probes can now be utilized in further investigations of the mechanisms of SPR function, including receptor localization, internalization and recycling.

Tags: fluorescent-analogs, neurotransmitter-binding, nih, receptor-activation, substance-p
Organization: U.S. Department of Health & Human Services
Table 4. 2011-2012 NSDUH Perceptions of Great Risk of Smoking Marijuana Once a Month, by Age Group and State

Table 4. Perceptions of Great Risk of Smoking Marijuana Once a Month, by Age Group and State: Percentages, Annual Averages Based on 2011 and 2012 NSDUHs. Results are provided by State and age groups.

Tags: adolescent-risk-behavior, marijuana-risk-perception, nsduh-data, samhsa, substance-use-perception
Organization: U.S. Department of Health & Human Services
Treatment Episode Data Set (TEDS): 2020 Admissions To And Discharges From Publicly Funded Substance Use Treatment Facilities

This report presents national- and state-level data from the Treatment Episode Data Set (TEDS) for admissions and discharges occurring in 2020, and trend data from 2010 to 2021. It summarizes demographic information and the characteristics and outcomes of treatment for alcohol and/or drug use among clients aged 12 years and older in facilities that report to individual state administrative data systems. Data include records for treatment admissions and discharges that were received and processed through November 22, 2021.

Tags: alcohol-drug-abuse, samhsa, substance-use-treatment, teds-admissions, treatment-outcomes
Organization: U.S. Department of Health & Human Services
Treatment Episode Data Set (TEDS) 2008 Discharges from Substance Abuse Treatment Services

This report presents results from the Treatment Episode Data Set (TEDS) for clients discharged from substance abuse treatment in 2008. The report provides information on treatment completion, length of stay in treatment, and demographic and substance abuse characteristics of people aged 12 and older discharged from alcohol or drug treatment in facilities that reported to individual state administrative data systems.

Tags: alcohol-drug-treatment, samhsa, substance-abuse-treatment, teds-discharges, treatment-episode-data
Organization: U.S. Department of Health & Human Services
The Adaptive Evolution Database (TAED)

Background
          The Master Catalog is a collection of evolutionary families, including multiple sequence alignments, phylogenetic trees and reconstructed ancestral sequences, for all protein-sequence modules encoded by genes in GenBank. It can therefore support large-scale genomic surveys, of which we present here The Adaptive Evolution Database (TAED). In TAED, potential examples of positive adaptation are identified by high values for the normalized ratio of nonsynonymous to synonymous nucleotide substitution rates (KA/KS values) on branches of an evolutionary tree between nodes representing reconstructed ancestral sequences.
        
        
          Results
          Evolutionary trees and reconstructed ancestral sequences were extracted from the Master Catalog for every subtree containing proteins from the Chordata only or the Embryophyta only. Branches with high KA/KS values were identified. These represent candidate episodes in the history of the protein family when the protein may have undergone positive selection, where the mutant form conferred more fitness than the ancestral form. Such episodes are frequently associated with change in function. An unexpectedly large number of families (between 10% and 20% of those families examined) were found to have at least one branch with high KA/KS values above arbitrarily chosen cut-offs (1 and 0.6). Most of these survived a robustness test and were collected into TAED.
        
        
          Conclusions
          TAED is a raw resource for bioinformaticists interested in data mining and for experimental evolutionists seeking candidate examples of adaptive evolution for further experimental study. It can be expanded to include other evolutionary information (for example changes in gene regulation or splicing) placed in a phylogenetic perspective.

Tags: adaptive-evolution, nih, phylogenetic-trees, protein-sequences, sequence-alignment
Organization: U.S. Department of Health & Human Services
Percutaneous removal of a knotted pulmonary artery catheter using a
		  tracheostomy dilator

This case report describes removal of a knotted, subclavian,
			 pulmonary artery catheter using a tracheostomy dilator. With this simple method
			 an invasive procedure might be averted.

Tags: catheter-removal, nih, pulmonary-artery, pulmonary-artery-catheter, tracheostomy-dilator
Organization: U.S. Department of Health & Human Services
2013 CMHS Uniform Reporting System (URS) Table for Wyoming

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Tables for Wyoming for 2013. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program.  State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, national-outcome-measures, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
Rhode Island 2016 Potential Areas for Addressing Service Gaps for Opioid Treatment

The purpose of the medication-assisted treatment (MAT) facility maps is to identify areas on a state-by-state basis that may be potentially underserved by existing treatment facilities. The maps are created with a methodology that seeks to include the highest potential need areas from individual counties so that county-level stakeholders are also informed. The maps are meant to be used as a tool for policy makers to determine potentially underserved areas—not as a definitive representation of these areas.

Tags: mat-access, opioid-treatment, rhode-island, samhsa, service-gap-analysis
Organization: U.S. Department of Health & Human Services
Hospital competition, resource allocation and quality of care

Background
          A variety of approaches have been used to contain escalating hospital costs. One approach is intensifying price competition. The increase in price based competition, which changes the incentives hospitals face, coupled with the fact that consumers can more easily evaluate the quality of hotel services compared with the quality of clinical care, may lead hospitals to allocate more resources into hotel rather than clinical services.
        
        
          Methods
          To test this hypothesis we studied hospitals in California in 1982 and 1989, comparing resource allocations prior to and following selective contracting, a period during which the focus of competition changed from quality to price. We estimated the relationship between clinical outcomes, measured as risk-adjusted-mortality rates, and resources.
        
        
          Results
          In 1989, higher competition was associated with lower clinical expenditures levels compared with 1982. The trend was stronger for non-profit hospitals. Lower clinical resource use was associated with worse risk adjusted mortality outcomes.
        
        
          Conclusions
          This study raises concerns that cost reductions may be associated with increased mortality.

Tags: clinical-expenditures, hospital-competition, mortality-rates, nih, resource-allocation
Organization: U.S. Department of Health & Human Services
NSDUH 2017 Questionnaire Dwelling Unit-Level and Person Pair-Level Sampling Weight Calibration

NSDUH allows for estimating characteristics at the person level, pair level, and household or QDU level. This report describes the weight calibration methods used for the pair- and QDU-level respondents. As described in the person-level report, NSDUH is an annual survey of about 67,500 people selected from the civilian, noninstitutionalized population aged 12 or older from all 50 states and the District of Columbia. A coordinated sample design was developed for the 2014 through 2017 NSDUHs. The coordinated design facilitated 50 percent overlap in third-stage units (area segments) within each successive 2-year period from 2014 through 2017.

Tags: household-survey, nsduh-survey, samhsa, sampling-weights, substance-use
Organization: U.S. Department of Health & Human Services
Analysis of strain and regional variation in gene expression in mouse brain

Background
          We performed a statistical analysis of a previously published set of gene expression microarray data from six different brain regions in two mouse strains. In the previous analysis, 24 genes showing expression differences between the strains and about 240 genes with regional differences in expression were identified. Like many gene expression studies, that analysis relied primarily on ad hoc 'fold change' and 'absent/present' criteria to select genes. To determine whether statistically motivated methods would give a more sensitive and selective analysis of gene expression patterns in the brain, we decided to use analysis of variance (ANOVA) and feature selection methods designed to select genes showing strain- or region-dependent patterns of expression.
        
        
          Results
          Our analysis revealed many additional genes that might be involved in behavioral differences between the two mouse strains and functional differences between the six brain regions. Using conservative statistical criteria, we identified at least 63 genes showing strain variation and approximately 600 genes showing regional variation. Unlike ad hoc methods, ours have the additional benefit of ranking the genes by statistical score, permitting further analysis to focus on the most significant. Comparison of our results to the previous studies and to published reports on individual genes show that we achieved high sensitivity while preserving selectivity.
        
        
          Conclusions
          Our results indicate that molecular differences between the strains and regions studied are larger than indicated previously. We conclude that for large complex datasets, ANOVA and feature selection, alone or in combination, are more powerful than methods based on fold-change thresholds and other ad hoc selection criteria.

Tags: anova-analysis, gene-expression, mouse-brain, nih, strain-variation
Organization: U.S. Department of Health & Human Services
Humoral immune response to an allogenic foetus in normal fertile women and recurrent aborters

Background
          Several humoral immune factors are responsible for a successful pregnancy. There are a few studies, which demonstrate the role of antipaternal cytotoxic antibodies (APCA) and mixed lymphocyte reaction blocking factor (MLR-Bf) in the maintenance of pregnancy. However, these factors have not been studied in women with history of recurrent spontaneous abortion (RSA). We designed this study to review the role of APCA and MLR-Bf in normal pregnancy as well as in women with a history of RSA.
        
        
          Methods
          One hundred and five women with unexplained recurrent spontaneous abortion were included in the present study. These women were screened for all other known causes of recurrent abortion. We also included 60 normal fertile women, fifteen from each trimester and fifteen women during the post partum period (up to six months). RSA and controls (normal pregnancy) were matched for age, caste, and socio economic background and also for parity. APCA and MLR-Bf were evaluated in all the groups. All women with RSA who conceived during the study period were on follow up.
        
        
          Results
          We have analyzed the status of APCA and MLR-Bf in normal pregnancy (different gestational periods and during post partum), and in women with history of RSA. Our results show that APCA was significantly higher in controls as compared to RSA women. MLR-Bf was directed against the husbands' cells in normal pregnancy and was virtually absent in RSA women.
        
        
          Conclusion
          Our results indicate that there is a significantly low titer of APCA and MLR-Bf in women with recurrent spontaneous abortion. This highlights the role of these factors in the maintenance of successful pregnancy.

Tags: antipaternal-antibodies, humoral-immunity, nih, pregnancy-outcomes, recurrent-abortion
Organization: U.S. Department of Health & Human Services