AndreaBozzo/ceres-open-data-index huggingface dataset:
Case-oriented computer-based-training in radiology: concept, implementation and evaluation

Background
          Providing high-quality clinical cases is important for teaching radiology. We developed, implemented and evaluated a program for a university hospital to support this task.
        
        
          Methods
          The system was built with Intranet technology and connected to the Picture Archiving and Communications System (PACS). It contains cases for every user group from students to attendants and is structured according to the ACR-code (American College of Radiology) [2]. Each department member was given an individual account, could gather his teaching cases and put the completed cases into the common database.
        
        
          Results
          During 18 months 583 cases containing 4136 images involving all radiological techniques were compiled and 350 cases put into the common case repository. Workflow integration as well as individual interest influenced the personal efforts to participate but an increasing number of cases and minor modifications of the program improved user acceptance continuously. 101 students went through an evaluation which showed a high level of acceptance and a special interest in elaborate documentation.
        
        
          Conclusion
          Electronic access to reference cases for all department members anytime anywhere is feasible. Critical success factors are workflow integration, reliability, efficient retrieval strategies and incentives for case authoring.

Tags: clinical-case-repository, computer-based-training, medical-imaging, nih, radiology-education
Organization: U.S. Department of Health & Human Services
Publications Using SAMHSA Data2015 CMHS Uniform Reporting System (URS) Table for Oklahoma

2015 Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for Oklahoma. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: mental-health-services, national-outcome-measures, oklahoma-mental-health, samhsa, urs-data
Organization: U.S. Department of Health & Human Services
Application of the development stages of a cluster randomized trial to a framework for evaluating complex health interventions

Introduction
          Trials of complex health interventions often pose difficult methodologic challenges. The objective of this paper is to assess the extent to which the various development steps of a cluster randomized trial to optimize antibiotic use in nursing homes are represented in a recently published framework for the design and evaluation of complex health interventions. In so doing, the utility of the framework for health services researchers is evaluated.
        
        
          Methods
          Using the five phases of the framework (theoretical, identification of components of the intervention, definition of trial and intervention design, methodological issues for main trial, promoting effective implementation), corresponding stages in the development of the cluster randomized trial using diagnostic and treatment algorithms to optimize the use of antibiotics in nursing homes are identified and described.
        
        
          Results
          Synthesis of evidence needed to construct the algorithms, survey and qualitative research used to define components of the algorithms, a pilot study to assess the feasibility of delivering the algorithms, methodological issues in the main trial including choice of design, allocation concealment, outcomes, sample size calculation, and analysis are adequately represented using the stages of the framework.
        
        
          Conclusions
          The framework is a useful resource for researchers planning a randomized clinical trial of a complex intervention.

Tags: antibiotic-use, cluster-randomized-trial, health-intervention, nih, nursing-homes
Organization: U.S. Department of Health & Human Services
2011 State Profile — Puerto Rico

This is a National Survey of Substance Abuse Treatment Services (N-SSATS) data table showing state profiles for Puerto Rico in 2011. N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 States, the District of Columbia, and other U.S. jurisdictions.

Tags: n-ssats, puerto-rico, samhsa, substance-abuse-treatment, treatment-facilities
Organization: U.S. Department of Health & Human Services
Fluctuations of inspired concentrations of nitric oxide and nitrogen
		  dioxide during mechanical ventilation

Background:
          Nitric oxide (NO) is a very reactive agent with potentially toxic
				oxidation products such as nitrogen dioxide (NO2). Therefore, during
				NO inhalation a constant inspired concentration and accurate measurement of NO
				and NO2 concentrations are essential. The objective of this study
				was to test the NO concentrations at various positions along the inspiratory
				limb of the breathing circuit using a recently developed system to administer
				NO in phase with inspiratory flow during mechanical ventilation (Servo 300
				NO-A, Siemens, Sweden). Furthermore, we tested whether an active heating system
				would interfere with inspired NO concentrations.
        
        
          Results:
          A sharp decline in the NO concentration was found between the
				respirator's inspiratory outlet and more distal points along the inspiratory
				limb of the circuit. This finding was most evident when an active heating
				system was mounted between those points.
        
        
          Conclusions:
          The concentrations of NO and NO2 should be measured as
				near to the patient as possible, as significant fluctuations of these
				concentrations might be found along the inspiratory limb of the respiratory
				circuit especially when an active heating system is used.

Tags: mechanical-ventilation, nih, nitric-oxide-inhalation, nitrogen-dioxide, respiratory-therapy
Organization: U.S. Department of Health & Human Services
The mouse anterior chamber angle and trabecular meshwork develop 
without cell death

Background
          The iridocorneal angle forms in the mammalian eye from undifferentiated 
mesenchyme between the root of the iris and cornea. A major component is the 
trabecular meshwork, consisting of extracellular matrix organized into a 
network of beams, covered in trabecular endothelial cells. Between the beams, 
channels lead to Schlemm's canal for the drainage of aqueous humor from the eye 
into the blood stream. Abnormal development of the iridocorneal angle that 
interferes with ocular fluid drainage can lead to glaucoma in humans. Little is 
known about the precise mechanisms underlying angle development. There are two 
main hypotheses. The first proposes that morphogenesis involves mainly cell 
differentiation, matrix deposition and assembly of the originally continuous 
mesenchymal mass into beams, channels and Schlemm's canal. The second, based 
primarily on rat studies, proposes that cell death and macrophages play an 
important role in forming channels and beams. Mice provide a potentially useful 
model to understand the origin and development of angle structures and how 
defective development leads to glaucoma. Few studies have assessed the normal 
structure and development of the mouse angle. We used light and electron 
microscopy and a cell death assay to define the sequence of events underlying 
formation of the angle structures in mice.
        
        
          Results
          The mouse angle structures and developmental sequence are similar to those 
in humans. Cell death was not detectable during the period of trabecular 
channel and beam formation.
        
        
          Conclusions
          These results support morphogenic mechanisms involving organization of 
cellular and extracellular matrix components without cell death or atrophy.

Tags: aqueous-humor-drainage, glaucoma-development, iridocorneal-angle, nih, trabecular-meshwork
Organization: U.S. Department of Health & Human Services
2019-2020 NSDUH State-Specific Tables

State estimates for these years are no longer available due to methodological concerns with combining 2019 and 2020 data. We apologize for any inconvenience or confusion this may causeBecause of the COVID-19 pandemic, most respondents answered the survey via the web in Quarter 4 of 2020, even though all responses in Quarter 1 were from in-person interviews. It is known that people may respond to the survey differently while taking it online, thus introducing what is called a mode effect.When the state estimates were released, it was assumed that the mode effect was similar for different groups of people. However, later analyses have shown that this assumption should not be made. Because of these analyses, along with concerns about the rapid societal changes in 2020, it was determined that averages across the two years could be misleading.For more detail on this decision, see the 2019-2020state data page.

Tags: mental-health, nsduh, samhsa, substance-use, survey-data
Organization: U.S. Department of Health & Human Services
2019 Uniform Reporting System (URS) Table for Texas

These are the 2019 Uniform Reporting System (URS) Output Tables for Texas. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant, mental-health-services, noms, samhsa, texas
Organization: U.S. Department of Health & Human Services
A systematic review of the quality of homeopathic clinical trials

Background
          While a number of reviews of homeopathic clinical trials have been done, all have used methods dependent on allopathic diagnostic classifications foreign to homeopathic practice. In addition, no review has used established and validated quality criteria allowing direct comparison of the allopathic and homeopathic literature.
        
        
          Methods
          In a systematic review, we compared the quality of clinical-trial research in homeopathy to a sample of research on conventional therapies using a validated and system-neutral approach. All clinical trials on homeopathic treatments with parallel treatment groups published between 1945–1995 in English were selected. All were evaluated with an established set of 33 validity criteria previously validated on a broad range of health interventions across differing medical systems. Criteria covered statistical conclusion, internal, construct and external validity. Reliability of criteria application is greater than 0.95.
        
        
          Results
          59 studies met the inclusion criteria. Of these, 79% were from peer-reviewed journals, 29% used a placebo control, 51% used random assignment, and 86% failed to consider potentially confounding variables. The main validity problems were in measurement where 96% did not report the proportion of subjects screened, and 64% did not report attrition rate. 17% of subjects dropped out in studies where this was reported. There was practically no replication of or overlap in the conditions studied and most studies were relatively small and done at a single-site. Compared to research on conventional therapies the overall quality of studies in homeopathy was worse and only slightly improved in more recent years.
        
        
          Conclusions
          Clinical homeopathic research is clearly in its infancy with most studies using poor sampling and measurement techniques, few subjects, single sites and no replication. Many of these problems are correctable even within a "holistic" paradigm given sufficient research expertise, support and methods.

Tags: alternative-medicine-trials, clinical-trial-validity, homeopathic-clinical-trials, homeopathy-research-quality, nih
Organization: U.S. Department of Health & Human Services
Results from the 2010 National Survey on Drug Use and Health: Summary of National Findings

This report presents results from the 2010 National Survey on Drug Use and Health (NSDUH). The report includes national estimates of rates of initiation and use of illicit drugs (e.g., marijuana, cocaine, heroin, hallucinogens, inhalants, and the nonmedical use of prescription-type pain relievers, tranquilizers, stimulants, and sedatives), alcohol, and tobacco products and rates of driving under the influence of drugs or alcohol. The report also covers substance use treatment need/receipt and youth risk and prevention measures. Results are provided for age group, gender, pregnancy status, race/ethnicity, education level, employment status, geographic area, parole/probation status. Comparisons are made between 2010 and 2002 to 2009.

Tags: alcohol-tobacco-use, drug-use-survey, mental-health, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Publications Using SAMHSA Data2012 Uniform Reporting  System (URS) Tables for Minnesota

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2012. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-program, mental-health-services, national-outcome-measures, samhsa, urs-data
Organization: U.S. Department of Health & Human Services
2022 Uniform Reporting System (URS) Table For Northern Mariana Islands

This is the 2022 Uniform Reporting System (URS) Output Tables for Northern Mariana Islands. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-program, mental-health-services, national-outcome-measures, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
Advances in Targeted Therapies III, Nassau, Bahamas, 27 April-1 May 2001

This conference was the third in a series focusing on developments in the therapy of rheumatoid arthritis (RA) and other rheumatic conditions with biologicals; in many ways, it was perhaps the best one so far. One strength of the meeting was the mix of scientists from academia and from industry, and of workers in basic science as well as clinical investigators. The risks of inhibition of tumor necrosis factor (TNF) were covered in depth for the first time. A number of putative and actual new targets were presented. An updated consensus document on the use of TNF inhibitors will appear in the near future in the Annals of Rheumatic Diseases, authored by Dan Furst et al.

Tags: nih, rheumatic-diseases, rheumatoid-arthritis, targeted-therapies, tnf-inhibitors
Organization: U.S. Department of Health & Human Services
Amyloid associated with elastin-staining laminar aggregates in the lungs of patients diagnosed with acute respiratory distress syndrome

Background
          The heterogeneity of conditions underlying respiratory distress, whether classified clinically as acute lung injury (ALI) or the more severe acute respiratory distress syndrome (ARDS), has hampered efforts to identify and more successfully treat these patients. Examination of postmortem lungs among cases clinically diagnosed as ARDS identified a cohort that showed a consistent morphology at the light and electron microscope levels, and featured pathognomonic structures which we termed elastin-staining laminar structures (ELS).
        
        
          Methods
          Postmortem tissues were stained using the Verhoeff-Van Gieson procedure for elastic fibers, and with Congo red for examination under a polarizing microscope. Similar samples were examined by transmission EM.
        
        
          Results
          The pathognomonic ELS presented as ordered molecular aggregates when stained using the Verhoeff-van Gieson technique for elastic fibers. In several postmortem lungs, the ELS also displayed apple-green birefringence after staining with Congo red, suggesting the presence of amyloid. Remarkably, most of the postmortem lungs with ELS exhibited no significant acute inflammatory cellular response such as neutrophilic reaction, and little evidence of widespread edema except for focal intra-alveolar hemorrhage.
        
        
          Conclusions
          Postmortem lungs that exhibit the ELS constitute a morphologically-identifiable subgroup of ARDS cases. The ordered nature of the ELS, as indicated by both elastin and amyloid stains, together with little morphological evidence of inflammation or edema, suggests that this cohort of ARDS may represent another form of conformational disease. If this hypothesis is confirmed, it will require a new approach in the diagnosis and treatment of patients who exhibit this form of acute lung injury.

Tags: amyloid-deposition, ards-lungs, elastin-aggregates, nih, postmortem-lung-tissue
Organization: U.S. Department of Health & Human Services
Publications Using SAMHSA DataBehavioral Health Barometer: HHS Region IV, 2014

This is a behavioral health report for HHS Region IV of the United States and utilizes data from the National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment (N-SSATS), collected annually. The topics addressed in the reports include youth mental health and treatment, adult mental health, substance use and substance use treatment.

Tags: behavioral-health, hhs-region-iv, mental-health, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Mapping of the Mouse Actin Capping Protein Beta Subunit Gene

Background
          Capping protein (CP), a heterodimer of α and β subunits, is found in all eukaryotes. CP binds to the barbed ends of actin filaments in vitro and controls actin assembly and cell motility in vivo. Vertebrates have three isoforms of CPβ produced by alternatively splicing from one gene; lower organisms have one gene and one isoform.
        
        
          Results
          We isolated genomic clones corresponding to the β subunit of mouse CP and identified its chromosomal location by interspecies backcross mapping.
        
        
          Conclusions
          The CPβ gene (Cappb1) mapped to Chromosome 4 between Cdc42 and D4Mit312. Three mouse mutations, snubnose, curly tail, and cribriform degeneration, map in the vicinity of the β gene.

Tags: actin-capping-protein, chromosome-4, gene-mapping, mouse-genome, nih
Organization: U.S. Department of Health & Human Services
The inhibitory effects of camptothecin, a topoisomerase I inhibitor, on collagen synthesis in fibroblasts from patients with systemic sclerosis

The main manifestation of systemic sclerosis (SSc) is the overproduction of extracellular matrix, predominantly type I collagen. This study was undertaken to evaluate the effects of noncytotoxic doses of the topoisomerase I inhibitor camptothecin (CPT) on collagen production in the activated dermal fibroblasts from patients with SSc and healthy donors. The fibroblasts were cultured in the presence or absence of CPT. Production of collagenous proteins by fibroblasts was determined in cell and matrix layers by ELISA and in conditioned media by [3H]proline incorporation, gel electrophoresis, and autoradiography. Expression of α2(I) collagen (COL1A2) mRNA was measured by northern blot, and the activity of COL1A2 promoter was determined by a chloramphenicol acetyltransferase assay. CPT (10-7 M) decreased the deposition of type I collagen by 68%, of type III by 38%, and of type VI by 21% in SSc fibroblasts and to a lesser degree in healthy controls. Similarly, CPT (10-8 M to 10-6 M) significantly inhibited secretion of newly synthesized collagenous proteins into conditioned media by 50%. CPT (10-8 M to 10-6 M) caused a significant dose-dependent inhibition of COL1A2 mRNA levels and COL1A2 promoter activity, both by as much as 60%. The inhibitory effect of CPT on collagen production by fibroblasts from patients with SSc suggests that topoisomerase I inhibitors may be effective in limiting fibrosis in such patients.

Tags: camptothecin-treatment, collagen-synthesis, fibroblast-activity, nih, systemic-sclerosis
Organization: U.S. Department of Health & Human Services
Compound 525343: 2,2,4,5-Tetramethyl-3-thiahexane

Chemical compound data from PubChem database. IUPAC Name: 2-tert-butylsulfanyl-3-methylbutane. Molecular Formula: C9H20S. Molecular Weight: 160.32. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 528517: Hexadecane, 4-propyl

Chemical compound data from PubChem database. IUPAC Name: 4-propylhexadecane. Molecular Formula: C19H40. Molecular Weight: 268.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2013 CMHS Uniform Reporting System (URS) Tables for California

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Tables for California for 2013. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program.  State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: california-mental-health, mental-health-services, noms-data, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
Publications Using SAMHSA DataTreatment Episode Data Set (TEDS) 2000-2010 State Admissions to Substance Abuse Treatment Services

This is the Treatment Episode Data Set (TEDS) State Admissions to Substance Abuse Treatment Services report. This report presents data by Census division and State or jurisdiction for admissions in 2010 and trend data for 2000 to 2010. Demographic and substance abuse characteristics are reported for admissions to treatment aged 12 and older for abuse of alcohol and/or drugs in facilities that report to individual State administrative data systems.

Tags: alcohol-drug-abuse, samhsa, substance-abuse-treatment, teds-admissions, treatment-episodes
Organization: U.S. Department of Health & Human Services