AndreaBozzo/ceres-open-data-index huggingface dataset:
Physiological-dose steroid therapy in sepsis [ISRCTN36253388]

Introduction
          The aim of the study was to assess the prognostic importance of basal cortisol concentrations and cortisol response to corticotropin, and to determine the effects of physiological dose steroid therapy on mortality in patients with sepsis.
        
        
          Methods
          Basal cortisol level and corticotropin stimulation test were performed within 24 hours in all patients. One group (20 patients) received standard therapy for sepsis and physiological-dose steroid therapy for 10 days; the other group (20 patients) received only standard therapy for sepsis. Basal cortisol level was measured on the 14th day in patients who recovered. The outcome of sepsis was compared.
        
        
          Results
          Only Sequential Organ Failure Assessment (SOFA) score was found related to mortality, independent from other factors in multivariate analysis. No significant difference was found between the changes in the percentage of SOFA scores of the steroid therapy group and the standard therapy group in survivors, nor between the groups in basal and peak cortisol levels, cortisol response to corticotropin test and mortality. The mortality rates among patients with occult adrenal insufficiencies were 40% in the steroid therapy group and 55.6% in the standard therapy group.
        
        
          Discussion
          There was a trend towards a decrease in the mortality rates of the patients with sepsis who received physiological-dose steroid therapy. In the advancing process from sepsis to septic shock, adrenal insufficiency was not frequent as supposed. There was a trend (that did not reach significance) towards a decrease in the mortality rates of the patients with sepsis who received physiological-dose steroid therapy.

Tags: cortisol-levels, nih, sepsis-treatment, sofa-score, steroid-therapy
Organization: U.S. Department of Health & Human Services
Compound 527373: 20,24-Dimethyl-dotriacontyl cyanide

Chemical compound data from PubChem database. IUPAC Name: 21,25-dimethyltritriacontanenitrile. Molecular Formula: C35H69N. Molecular Weight: 503.9. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Regular use of aspirin and pancreatic cancer risk

Background
          Regular use of aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) has been consistently associated with reduced risk of colorectal cancer and adenoma, and there is some evidence for a protective effect for other types of cancer. As experimental studies reveal a possible role for NSAIDs is reducing the risk of pancreatic cancer, epidemiological studies examining similar associations in human populations become more important.
        
        
          Methods
          In this hospital-based case-control study, 194 patients with pancreatic cancer were compared to 582 age and sex-matched patients with non-neoplastic conditions to examine the association between aspirin use and risk of pancreatic cancer. All participants received medical services at the Roswell Park Cancer Institute in Buffalo, NY and completed a comprehensive epidemiologic questionnaire that included information on demographics, lifestyle factors and medical history as well as frequency and duration of aspirin use. Patients using at least one tablet per week for at least six months were classified as regular aspirin users. Unconditional logistic regression was used to compute crude and adjusted odds ratios (ORs) with 95% confidence intervals (CIs).
        
        
          Results
          Pancreatic cancer risk in aspirin users was not changed relative to non-users (adjusted OR = 1.00; 95% CI 0.72–1.39). No significant change in risk was found in relation to greater frequency or prolonged duration of use, in the total sample or in either gender.
        
        
          Conclusions
          These data suggest that regular aspirin use may not be associated with lower risk of pancreatic cancer.

Tags: aspirin-use, case-control-study, nih, nsaid-use, pancreatic-cancer
Organization: U.S. Department of Health & Human Services
Patent AT-E401604-T1: [Translated] DATA BACKUP FOR APPLICATIONS ON AN ELECTRONIC MOBILE DEVICE

A method and system for data protection for applications that includes registering applications with a storage cleaning mechanism so that the registered applications can receive notification of impending storage cleaning operations. Upon receiving notification of an impending cleaning operation, the registered applications can release or unreference storage so it can be cleaned of data. <IMAGE>

Tags: chemistry, innovation, patent, pubchem, research
Organization: U.S. Department of Health & Human Services
2010 State Profile — Oregon

This state profile includes data from facilities in Oregon that reported to N-SSATS for the survey reference date March 31, 2010. Data were collected on the location, characteristics, services offered, and number of clients in treatment at alcohol and drug abuse treatment facilities (both public and private) in Oregon. In Oregon, 224 substance abuse treatment facilities were included in the 2010 N-SSATS, reporting that there were 20,435 clients in substance abuse treatment on March 31, 2010. The survey response rate in Oregon was 90.3%.

Tags: addiction-services, n-ssats, oregon, samhsa, substance-abuse-treatment
Organization: U.S. Department of Health & Human Services
Increased expression of ICAM-1, VCAM-1, MCP-1, and MIP-1α by spinal perivascular macrophages during experimental allergic encephalomyelitis in rats

Background
          T-cells extravasation and CNS parenchyma infiltration during autoimmune neurodegenerative disease can be evoked by local antigen presenting cells. Studying the chemoattracting potential of spinal perivascular macrophages (SPM) during experimental allergic encephalomyelitis (EAE), we observed numerous infiltrates of densely-packed mononuclear cells. Apart from the poor spatial and optical resolution, no differentiation between the resident SPM (mabs ED1+, ED2+) and the just recruited monocytes/macrophages (mab ED1+) was possible.
        
        
          Results
          This is why we labeled SPM by injections of different fluoresecent dyes into the lateral cerebral ventricle before induction of active EAE. Within an additional experimental set EAE was induced by an intraperitoneal injection of T-cells specifically sensitized to myelin basic protein (MBP) and engineered to express the green fluorescent protein (GFP). In both experiments we observed a strong activation of SPM (mabs OX6+, SILK6+, CD40+, CD80+, CD86+) which was accompanied by a consistently increased expression of ICAM-1, VCAM-1, and the chemokines MCP-1 and MIP-1α.
        
        
          Conclusion
          These observations indicate that SPM play a role in promoting lymphocyte extravasation.

Tags: eae-rats, icam-1-expression, nih, spinal-macrophages, vcam-1-expression
Organization: U.S. Department of Health & Human Services
Patent AT-E401099-T1: [Translated] ENDOLEAK INHIBITION KIT ASSOCIATED WITH ENDOVASCULAR REPAIR OF ABDOMINAL AORTIC ANEURYSMS

Disclosed are methods for inhibiting the formation of potential endoleaks associated with endovascular repair of abdominal aortic aneurysms which comprise the in situ embolization of blood vessels associated with the aneurysmal sac prior to placement of an endovascular prostheses in the abdominal aorta. Embolization of the blood vessels is achieved by injection of either a biocompatible polymer or prepolymer fluid composition into these vessels in a sufficient amount such that upon in situ solidification of this composition, blood circulation through these blood vessels and the aneurysmal sac ceases.

Tags: chemistry, innovation, patent, pubchem, research
Organization: U.S. Department of Health & Human Services
Compound 529969: Eicosane, 9-ethyl

Chemical compound data from PubChem database. IUPAC Name: 9-ethylicosane. Molecular Formula: C22H46. Molecular Weight: 310.6. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2021-2022 NSDUH: P-Value Tables for Geographic Comparison

Compare state-level estimates from the 2021-2022 National Surveys on Drug Use and Health (NSDUH) using p-values. The tables accompany the2021-2022 NSDUH State Estimates of Substance Use and Mental Disorders, and can be used to determine whether the difference in estimates between two geographic areas are statistically significant. Aguide to their useis also available.The tables are available in an Excel spreadsheet or a zip file containing CSV text files. Each tab or text file contains p-values for a particular measure and a particular age group.

Tags: mental-disorders, p-value-tables, samhsa, state-estimates, substance-use
Organization: U.S. Department of Health & Human Services
Compound 529502: (Z)-4-Hepten-2-yl butyrate

Chemical compound data from PubChem database. IUPAC Name: hept-4-en-2-yl butanoate. Molecular Formula: C11H20O2. Molecular Weight: 184.27. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Patent AT-E400748-T1: [Translated] HYDRAULIC DAMPING BEARING, ESPECIALLY FOR SUPPORTING THE ENGINE OF A MOTOR VEHICLE

Hydraulically-damped mounting, especially for supporting the engine of a motor vehicle, comprises a support spring (10) made of an elastically deformable material and supporting a mounting core (13) removably connected to a support arm (30), a working chamber (11) defined by the support spring and filled with a hydraulic fluid, and an equalization chamber (20) connected to the working chamber by an overflow channel (36) integrated in the support arm.  Preferred Features: The mounting core has a passage (14) receiving the support arm.

Tags: chemistry, innovation, patent, pubchem, research
Organization: U.S. Department of Health & Human Services
Compound 529427: 2(1H)-Naphthalenone, 1-methyl

Chemical compound data from PubChem database. IUPAC Name: 1-methyl-1H-naphthalen-2-one. Molecular Formula: C11H10O. Molecular Weight: 158.2. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
CFSR Technical Bulletin #9

This Technical Bulletin (TB) rescinds TB#8A and establishes a new plan for use of statewide data indicators and national standards as context data for the third round of the Child and Family Services Reviews (CFSRs). This TB reissues and revises applicable guidance formerly from TB#8A on program improvement plan measurement methods to reflect the change in the use of the statewide data indicators.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: child, guidance, policy, reporting, standard
Organization: U.S. Department of Health & Human Services
Compound 529288: 3-Heptyne, 5-ethyl-2,2,5-trimethyl

Chemical compound data from PubChem database. IUPAC Name: 5-ethyl-2,2,5-trimethylhept-3-yne. Molecular Formula: C12H22. Molecular Weight: 166.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 526441: 10-Methyl-7,8,9,10-tetrahydro-6H-azepino[2,1-b]quinazolin-12-one

Chemical compound data from PubChem database. IUPAC Name: 10-methyl-7,8,9,10-tetrahydro-6H-azepino[2,1-b]quinazolin-12-one. Molecular Formula: C14H16N2O. Molecular Weight: 228.29. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 530435: 4-Ethylbenzoic acid, cyclobutyl ester

Chemical compound data from PubChem database. IUPAC Name: cyclobutyl 4-ethylbenzoate. Molecular Formula: C13H16O2. Molecular Weight: 204.26. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 528566: 3-Methyladipic acid, diTBDMS

Chemical compound data from PubChem database. IUPAC Name: bis[tert-butyl(dimethyl)silyl] 3-methylhexanedioate. Molecular Formula: C19H40O4Si2. Molecular Weight: 388.7. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 530088: 2,6-Dithioxanthine, TMS

Chemical compound data from PubChem database. IUPAC Name: trimethyl-(9-trimethylsilyl-2-trimethylsilylsulfanylpurin-6-yl)sulfanylsilane. Molecular Formula: C14H28N4S2Si3. Molecular Weight: 400.8. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 526309: 2,3,4,6,9-Pentabromo-dibenzofuran

Chemical compound data from PubChem database. IUPAC Name: 1,4,6,7,8-pentabromodibenzofuran. Molecular Formula: C12H3Br5O. Molecular Weight: 562.7. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 530399: 2,5-Dimethyl-3-(1-propenyl)-pyrazine

Chemical compound data from PubChem database. IUPAC Name: 2,5-dimethyl-3-prop-1-enylpyrazine. Molecular Formula: C9H12N2. Molecular Weight: 148.2. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Physical Health Conditions among Adolescents with Major Depressive Episode  (MH9)

The proposed study will utilize the National Survey on Drug Use and Health (NSDUH), which measures MDE and self-reported medical conditions among adolescents aged 12 to 17. Self-reported height and weight were also collected starting in 2013, from which body mass index will be computed. Initially, estimates of physical health conditions among adolescents with and without MDE will be reported. Further analyses will explore the demographic characteristics and other factors identified in the literature that may contribute to increased risk for physical health conditions among adolescents with MDE compared to those without MDE. Higher level analyses will employ logistic regression or other appropriate methods to assess and adjust for confounding factors in the association between MDE and physical health conditions among adolescents.Physical Health Conditions among Adolescents with Major Depressive Episode  (MH9)

Tags: adolescent-depression, adolescent-health, nsduh-data, physical-health-comorbidity, samhsa
Organization: U.S. Department of Health & Human Services
State Panel Discussion Cloud Computing

The Children's Bureau hosted a state panel discussion on implementing cloud computing/cloud solutions for child welfare information systems. This discussion included a description and background of each state’s implementation of a cloud solution, maintenance and enhancements of the systems with this approach, and lessons learned. The panel concluded with a question and answer session.

The speakers for this panel were:Arizona

Florida

Maryland

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: child, cloud, policy, sery, time
Organization: U.S. Department of Health & Human Services
Compound 527590: 3-Buten-1-ol, bromoacetate

Chemical compound data from PubChem database. IUPAC Name: but-3-enyl 2-bromoacetate. Molecular Formula: C6H9BrO2. Molecular Weight: 193.04. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Patent AT-E40044-T1: [Translated] VACCINE FOR THE PROTECTION OR INHIBITION OF HUMAN TOOTH ROOT INDUCED BY CARTOGENIC STREPTOCOCCUS MUTANS.

A vaccine comprising as active ingredient living cells of a Human mutant strain of Streptococcus mutans is effective to specifically inhibit the growth of cariogenic wild strains of Streptococcus mutans and may be used for preventing or inhibiting Streptococcus mutans induced dental caries. The mutant strain is substantially deficient in cariogenic potential and may be isolated from human oral flora or may be artificially induced from cariogenic wild strains of S. mutans. The non-cariogenic mutant strain may be administered in the form of a food composition such as a drink, comprising living cells, of the mutant strain in association with a liquid carrier conventionally used for preparing drinks containing the living cells of edible lactic acid-producing bacilli. When the living cells of the non-cariogenic mutant strain of this invention and the living cells of edible lactic acid-producing bacilli are mixed, for example, in the form of yogurt, the cariogenic potentials of both the cariogenic S. mutans and the edible lactic acid-producing bacilli may be prevented or inhibited effectively.

Tags: chemistry, innovation, patent, pubchem, research
Organization: U.S. Department of Health & Human Services
Compound 525211: Chloromethyl 5-chlorohexanoate

Chemical compound data from PubChem database. IUPAC Name: chloromethyl 5-chlorohexanoate. Molecular Formula: C7H12Cl2O2. Molecular Weight: 199.07. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 526470: Hexyl perfluoroheptanoate

Chemical compound data from PubChem database. IUPAC Name: hexyl 2,2,3,3,4,4,5,5,6,6,7,7,7-tridecafluoroheptanoate. Molecular Formula: C13H13F13O2. Molecular Weight: 448.22. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
National Survey of Substance Abuse Treatment Services (N-SSATS): 2000 Data on Substance Abuse Treatment Facilities

This report presents results from the 2000 National Survey of Substance Abuse Treatment Services (N-SSATS), an annual survey of facilities providing substance abuse treatment. Conducted by the Substance Abuse and Mental Health Services Administration (SAMHSA), the N-SSATS is designed to collect data on the location, characteristics, and use of alcoholism and drug abuse treatment facilities and services throughout the 50 states, the District of Columbia, and other U.S. jurisdictions.

Tags: alcoholism-treatment, n-ssats, samhsa, substance-abuse-treatment, treatment-facility-survey
Organization: U.S. Department of Health & Human Services
6.8 Million Adults Had Both Mental Illness and Substance Use Disorder (2011 NSDUH)

This report uses 2011 National Survey on Drug Use and Health (NSDUH) to assess past year substance use disorder (SUD) and mental illness statuses among adults aged 18 or older. Results are shown for people with SUD but no mental illness, co-occurring SUD and mental illness, and mental illness but no SUD.

Tags: adult-mental-health, co-occurring-disorders, mental-illness, samhsa, substance-use-disorder
Organization: U.S. Department of Health & Human Services
Connecticut (CT)

This report presents Connecticut\'s estimates for 25 measures of substance use and mental health based on the combined 2009 and 2010 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for Connecticut for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: connecticut, mental-health, nsduh-data, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Compound 527527: Propanoic acid, 2-chloro, undecyl ester

Chemical compound data from PubChem database. IUPAC Name: undecyl 2-chloropropanoate. Molecular Formula: C14H27ClO2. Molecular Weight: 262.81. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
NYTD Reviewer Recruitment Postcard for Young People

This young-person-friendly postcard, developed in collaboration with National Youth in Transition Database (NYTD) Reviewers, provides recruitment details and information to prospective NYTD Reviewers about what to expect from participation in the NYTD Reviews.

If you are interested in learning more about becoming a NYTD Reviewer, please email the Child Welfare Compliance Reviews Team at cw-mail@jbsinternational.com for additional information, or check out NYTD Reviewer Responsibilities at https://www.acf.hhs.gov/cb/report/nytd-reviewer-responsibilities.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: child, compliance, policy, reporting, scope
Organization: U.S. Department of Health & Human Services