AndreaBozzo/ceres-open-data-index huggingface dataset:
Compound 528408: Oxazole, 4-methyl-2,5-dipropyl

Chemical compound data from PubChem database. IUPAC Name: 4-methyl-2,5-dipropyl-1,3-oxazole. Molecular Formula: C10H17NO. Molecular Weight: 167.25. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Fibromyalgia syndrome improved using a mostly raw vegetarian diet: An observational study

Background
          Fibromyalgia engulfs patients in a downward, reinforcing cycle of unrestorative sleep, chronic pain, fatigue, inactivity, and depression. In this study we tested whether a mostly raw vegetarian diet would significantly improve fibromyalgia symptoms.
        
        
          Methods
          Thirty people participated in a dietary intervention using a mostly raw, pure vegetarian diet. The diet consisted of raw fruits, salads, carrot juice, tubers, grain products, nuts, seeds, and a dehydrated barley grass juice product. Outcomes measured were dietary intake, the fibromyalgia impact questionnaire (FIQ), SF-36 health survey, a quality of life survey (QOLS), and physical performance measurements.
        
        
          Results
          Twenty-six subjects returned dietary surveys at 2 months; 20 subjects returned surveys at the beginning, end, and at either 2 or 4 months of intervention; 3 subjects were lost to follow-up. The mean FIQ score (n = 20) was reduced 46% from 51 to 28. Seven of the 8 SF-36 subscales, bodily pain being the exception, showed significant improvement (n = 20, all P for trend < 0.01). The QOLS, scaled from 0 to 7, rose from 3.9 initially to 4.9 at 7 months (n = 20, P for trend 0.000001). Significant improvements (n = 18, P < 0.03, paired t-test) were seen in shoulder pain at rest and after motion, abduction range of motion of shoulder, flexibility, chair test, and 6-minute walk. 19 of 30 subjects were classified as responders, with significant improvement on all measured outcomes, compared to no improvement among non-responders. At 7 months responders' SF-36 scores for all scales except bodily pain were no longer statistically different from norms for women ages 45–54.
        
        
          Conclusion
          This dietary intervention shows that many fibromyalgia subjects can be helped by a mostly raw vegetarian diet.

Tags: fibromyalgia-syndrome, fiq-score, nih, sf-36-survey, vegetarian-diet
Organization: U.S. Department of Health & Human Services
Compound 525262: guanidine, N,N,N',N'-tetramethyl-N''-phenyl-

Chemical compound data from PubChem database. IUPAC Name: 1,1,3,3-tetramethyl-2-phenylguanidine. Molecular Formula: C11H17N3. Molecular Weight: 191.27. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Table 2. Marijuana Use in the Past Year among Persons Aged 12 or Older, by State and Substate Regions: Percentages, Annual Averages Based on 2010, 2011, and 2012 NSDUHs

Table 2. Marijuana Use in the Past Year among Persons Aged 12 or Older, by State and Substate Regions: Percentages, Annual Averages Based on 2010, 2011, and 2012 NSDUHs

Tags: adolescent-health, marijuana-use, nsduh-data, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Summaries of State Legislation Enacted in Response to the Adoption and Safe Family Act of 1997

Summaries of State Legislation Enacted in Response to the Adoption and Safe Family Act of 1997
  
  

 - This website provides information about state legislatures and legislative policy on a variety of topics, including child welfare.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: adoption, child, data, policy, scope
Organization: U.S. Department of Health & Human Services
Alaska: 2011-2012 NSDUH

This report presents Alaska\'s estimates for 25 measures of substance use and mental health based on the combined 2011 and 2012 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided by State and for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: alaska-survey, mental-health, nsduh-data, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
2011 CMHS Uniform Reporting System (URS) Output Tables for Pennsylvania

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2011. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-program, community-mental-health, mental-health-services, outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Diversity and abundance of bacteria in an underground oil-storage cavity

Background
          Microorganisms inhabiting subterranean oil fields have recently attracted much attention. Since intact groundwater can easily be obtained from the bottom of underground oil-storage cavities without contamination by surface water, studies on such oil-storage cavities are expected to provide valuable information to understand microbial ecology of subterranean oil fields.
        
        
          Results
          DNA was extracted from the groundwater obtained from an oil-storage cavity situated at Kuji in Iwate, Japan, and 16S rRNA gene (16S rDNA) fragments were amplified by PCR using combinations of universal and Bacteria-specific primers. The sequence analysis of 154 clones produced 31 different bacterial sequence types (a unique clone or group of clones with sequence similarity of > 98). Major sequence types were related to Desulfotomaculum, Acetobacterium, Desulfovibrio, Desulfobacula, Zoogloea and Thiomicrospira denitrificans. The abundance in the groundwater of bacterial populations represented by these major sequence types was assessed by quantitative competitive PCR using specific primers, showing that five rDNA types except for that related to Desulfobacula shared significant proportions (more than 1%) of the total bacterial rDNA.
        
        
          Conclusions
          Bacteria inhabiting the oil-storage cavity were unexpectedly diverse. A phylogenetic affiliation of cloned 16S rDNA sequences suggests that bacteria exhibiting different types of energy metabolism coexist in the cavity.

Tags: 16s-rrna-gene, bacterial-diversity, microbial-ecology, nih, oil-storage-cavity
Organization: U.S. Department of Health & Human Services
Is endosonography an effective method for detection and local staging of the ampullary carcinoma? A prospective study

Background
          The relatively rare carcinoma of the ampulla of Vater is a neoplasia with a good prognosis compared to pancreatic cancer. Preoperative staging is important in planning the most suitable surgical intervention.
        
        
          Aim
          To prospectively evaluate the diagnostic accuracy of Endoscopic Ultrasonography (EUS) in comparison with conventional US and CT scan, in staging of patients with ampullary carcinoma.
        
        
          Patients and Methods
          20 patients (7 women and 13 men) with histologically proven carcinoma of the ampulla of Vater were assessed by EUS, CT scan and US. Results were compared to surgical findings.
        
        
          Results
          Endoscopic biopsies were diagnostic in 76% of the patients. Detection of ampullary cancer with US and CT scan was 15% and 20% respectively. Only indirect signs of the disease were identified in the majority of cases using these methods. Overall accuracy of EUS in detection of ampullary tumours was 100%. The EUS was significantly (p < 0.001) superior than US and CT scan in ampullary carcinoma detection. Tumour size, tumour extension and the existence of metastatic lymph nodes were also identified and EUS proved to be very useful for the preoperative classification both for the T and the N components of the TNM staging of this neoplasia. The diagnostic accuracy for tumour extension (T) was 82% and for detection of metastatic lymph nodes (N) was 71%.
        
        
          Conclusion
          EUS is more accurate in detecting ampullary cancer than US and CT scan. Tumor extension and locally metastatic lymph nodes are more accurately assessed by means of EUS than with other imaging methods.

Tags: ampullary-carcinoma, cancer-detection, endoscopic-ultrasonography, nih, tumor-staging
Organization: U.S. Department of Health & Human Services
2021-2022 NSDUH State Estimates of Substance Use and Mental Disorders

Find state-level estimates for 35 measures of substance use and mental health from the 2021-2022 National Surveys on Drug Use and Health (NSDUH). These estimates are based on small area estimation (SAE) methods in which state-level NSDUH data are combined with other data from smaller geographies. The combined data are used to create modeled state estimates of the civilian, noninstitutionalized population ages 12 and older.Along with the estimates, the collection includes an overview of the estimation methodology, a review of other state-level substance use and mental health data sources, and a document describing the groups used for mapping. The data are available in several forms: images of national maps and tables both overall and by age. There are also tables of p-values indicating whether differences between particular geographies are statistically significant.The indicators are presented in the following 37 tables:Drug use and Perceived RiskIllicit Drug Use in the Past MonthMarijuana Use in the Past YearMarijuana Use in the Past MonthPerceptions of Great Risk from Smoking Marijuana Once a MonthFirst Use of Marijuana in the Past Year (among those at risk for initiation)Illicit Drug Use Other than Marijuana in the Past MonthCocaine Use in the Past YearPerceptions of Great Risk from using Cocaine Once a MonthHeroin Use in the Past YearPerceptions of Great Risk from Trying Heroin Once or TwiceHallucinogen Use in the Past YearMethamphetamine Use in the Past YearPrescription Pain Reliever Misuse in the Past YearOpioid Misuse in the Past YearAlcoholAlcohol Use in the Past MonthBinge Alcohol Use in the Past MonthPerceptions of Great Risk from Having Five or More Drinks of an Alcoholic Beverage Once or Twice a WeekAlcohol Use, Binge Alcohol Use in the Past Month, and Perceptions of Great Risk from Having Five or More Drinks of an Alcoholic Beverage Once or Twice a Week (among people aged 12 to 20)TobaccoTobacco Product Use in the Past MonthCigarette Use in the Past MonthPerceptions of Great Risk from Smoking One or More Packs of Cigarettes per DaySubstance Use DisordersSubstance Use Disorder in the Past YearAlcohol Use Disorder in the Past YearAlcohol Use Disorder in the Past Year (among people aged 12 to 20)Drug Use Disorder in the Past YearPain Reliever Use Disorder in the Past YearOpioid Use Disorder in the Past YearSubstance Use TreatmentReceived Substance Use Treatment in the Past YearClassified as Needing Substance Use Treatment in the Past YearDid Not Receive Substance Use Treatment in the Past Year among those Classified as Needing Substance Use TreatmentMental IllnessAny Mental Illness in the Past YearSerious Mental Illness in the Past YearReceived Mental Health Treatment in the Past YearMajor Depressive Episode in the Past YearSuicidalityHad Serious Thoughts of Suicide in the Past YearMade Any Suicide Plans in the Past YearAttempted Suicide in the Past Year

Tags: mental-disorders, nsduh-data, samhsa, state-estimates, substance-use
Organization: U.S. Department of Health & Human Services
Molecular action of methotrexate in inflammatory diseases

Despite the recent introduction of biological response modifiers and potent new small-molecule antirheumatic drugs, the efficacy of methotrexate is nearly unsurpassed in the treatment of inflammatory arthritis. Although methotrexate was first introduced as an antiproliferative agent that inhibits the synthesis of purines and pyrimidines for the therapy of malignancies, it is now clear that many of the anti-inflammatory effects of methotrexate are mediated by adenosine. This nucleoside, acting at one or more of its receptors, is a potent endogenous anti-inflammatory mediator. In confirmation of this mechanism of action, recent studies in both animals and patients suggest that adenosine-receptor antagonists, among which is caffeine, reverse or prevent the anti-inflammatory effects of methotrexate.

Tags: adenosine-receptors, anti-inflammatory-effects, inflammatory-arthritis, methotrexate-action, nih
Organization: U.S. Department of Health & Human Services
ELITE II and Val-HeFT are different trials: together what do they tell us?

The Losartan Heart Failure Survival Study (ELITE II) and the Valsartan Heart Failure Trial (Val-HeFT) both evaluated the efficacy and tolerability of a selective angiotensin II receptor antagonist on morbidity and mortality in patients with symptomatic heart failure. The trials differed, however, in terms of their primary hypothesis, study design, and treatment regimens, and this must be taken into consideration when comparing and interpreting the data from these studies. The data are in many ways complementary, and add to our understanding of the optimal treatment of symptomatic heart failure. Additional studies are needed, however, to fully define the role of angiotensin II receptor antagonists in the management of this very heterogeneous group of patients.

Tags: angiotensin-receptor-antagonists, clinical-trials, heart-failure, mortality, nih
Organization: U.S. Department of Health & Human Services
2018-2019 NSDUH State Estimates Of Substance Use And Mental Disorders

These are the state-level estimates for combined 2018 and 2019 NSDUHs. Part 1 is released in late November and part 2 in February after the close of the NSDUH data collection.

Tags: mental-disorders, nsduh, samhsa, state-estimates, substance-use
Organization: U.S. Department of Health & Human Services
Compound 525253: Pentafluoropropionic acid, dodecyl ester

Chemical compound data from PubChem database. IUPAC Name: dodecyl 2,2,3,3,3-pentafluoropropanoate. Molecular Formula: C15H25F5O2. Molecular Weight: 332.35. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
New feature subset selection procedures for classification of expression profiles

Background
          Methods for extracting useful information from the datasets produced by microarray experiments are at present of much interest. Here we present new methods for finding gene sets that are well suited for distinguishing experiment classes, such as healthy versus diseased tissues. Our methods are based on evaluating genes in pairs and evaluating how well a pair in combination distinguishes two experiment classes. We tested the ability of our pair-based methods to select gene sets that generalize the differences between experiment classes and compared the performance relative to two standard methods. To assess the ability to generalize class differences, we studied how well the gene sets we select are suited for learning a classifier.
        
        
          Results
          We show that the gene sets selected by our methods outperform the standard methods, in some cases by a large margin, in terms of cross-validation prediction accuracy of the learned classifier. We show that on two public datasets, accurate diagnoses can be made using only 15-30 genes. Our results have implications for how to select marker genes and how many gene measurements are needed for diagnostic purposes.
        
        
          Conclusion
          When looking for differential expression between experiment classes, it may not be sufficient to look at each gene in a separate universe. Evaluating combinations of genes reveals interesting information that will not be discovered otherwise. Our results show that class prediction can be improved by taking advantage of this extra information.

Tags: disease-classification, feature-selection, gene-expression, microarray-analysis, nih
Organization: U.S. Department of Health & Human Services
Cost-utility of enoxaparin compared with unfractionated heparin in unstable coronary artery disease

Background
          Low molecular weight heparins hold several advantages over unfractionated heparin including convenience of administration. Enoxaparin is one such heparin licensed in the UK for use in unstable coronary artery disease (unstable stable angina and non-Q wave myocardial infarction). In these patients, two large randomised controlled trials and their meta-analysis showed small benefits for enoxaparin over unfractionated heparin at 30–43 days and potentially at one year.
          We found no relevant published full economic evaluations, only cost studies, one of which was conducted in the UK. The other studies, from the US, Canada and France, are difficult to interpret since their resource use and costs may not reflect UK practice.
        
        
          Methods
          We aimed to compare the benefits and costs of short-term treatment (two to eight days) with enoxaparin and unfractionated heparin in unstable coronary artery disease. We used published data sources to estimate the incremental cost per quality adjusted life year (QALY), adopting a NHS perspective and using 1998 prices.
        
        
          Results
          The base case was a 0.013 QALY gain and net cost saving of £317 per person treated with enoxaparin instead of unfractionated heparin. All but one sensitivity analysis showed net savings and QALY gains, the exception (the worst case) being a cost per QALY of £3,305. Best cases were a £495 saving and 0.013 QALY gain, or a £317 saving and 0.014 QALY gain per person.
        
        
          Conclusions
          Enoxaparin appears cost saving compared with unfractionated heparin in patients with unstable coronary artery disease. However, cost implications depend on local revascularisation practice.

Tags: enoxaparin, nih, non-q-wave-mi, unfractionated-heparin, unstable-angina
Organization: U.S. Department of Health & Human Services
2016  Uniform Reporting System (URS) Table for Puerto Rico

This is the 2016 Uniform Reporting System (URS) Output Tables for Puerto Rico. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-program, mental-health-services, national-outcome-measures, puerto-rico, samhsa
Organization: U.S. Department of Health & Human Services
Looking beyond 28-day all-cause mortality

A growing body of evidence indicates that survivors of intensive care have an impaired quality of life. It is not entirely clear from the available literature whether this impairment is a complication of critical illness or a complication of therapy. There is little evidence to guide physicians to treatments in the intensive care unit that will minimize the effects of critical illness on these sequelae. Although the study by Rublee and colleagues in this issue of Critical Care provides little clinically useful information about the effects of antithrombin III on quality of life, it provides some insight into the challenges that investigators will encounter as we try to incorporate these outcomes into studies of critical illness.

Tags: critical-illness, icu-survivors, nih, outcomes-research, quality-of-life
Organization: U.S. Department of Health & Human Services
Compound 528489: Eicosane, 5-ethyl

Chemical compound data from PubChem database. IUPAC Name: 5-ethylicosane. Molecular Formula: C22H46. Molecular Weight: 310.6. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
State Requirements for Electing Title IV-E Prevention and Family Services and Programs

This Program Instruction provides instructions on the requirements state title IV-E agencies must meet when electing the title IV-E prevention program. ACF-ACYF-CB-PI-24-07 supersedes ACF-ACYF-CB-PI-18-09 issued November 30, 2018, upon publication.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: child, instruction, policy, prevention, regulation
Organization: U.S. Department of Health & Human Services
Indiana (IN)

This report presents Indiana\'s estimates for 25 measures of substance use and mental health based on the combined 2009 and 2010 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for Indiana for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: major-depressive-episode, mental-health, samhsa, serious-mental-illness, substance-use
Organization: U.S. Department of Health & Human Services
2015 CMHS Uniform Reporting System (URS) Table for Texas

2015 Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for Texas. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant, mental-health-services, outcome-measures, samhsa, texas
Organization: U.S. Department of Health & Human Services
Compound 525095: 1,3-Dichloroisopropyl decanoate

Chemical compound data from PubChem database. IUPAC Name: 1,2-dichloropropan-2-yl decanoate. Molecular Formula: C13H24Cl2O2. Molecular Weight: 283.2. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services