AndreaBozzo/ceres-open-data-index huggingface dataset:
2010 CMHS Uniform Reporting System (URS) Output Tables for Kentucky

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2010. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, outcome-measures, samhsa, utilization-data
Organization: U.S. Department of Health & Human Services
Anti-HIV-1 activity of cellulose acetate phthalate: Synergy with soluble CD4 and induction of "dead-end" gp41 six-helix bundles

Background
          Cellulose acetate phthalate (CAP), a promising candidate microbicide for prevention of sexual transmission of the human immunodeficiency virus type 1 (HIV-1) and other sexually transmitted disease (STD) pathogens, was shown to inactivate HIV-1 and to block the coreceptor binding site on the virus envelope glycoprotein gp120. It did not interfere with virus binding to CD4. Since CD4 is the primary cellular receptor for HIV-1, it was of interest to study CAP binding to HIV-1 complexes with soluble CD4 (sCD4) and its consequences, including changes in the conformation of the envelope glycoprotein gp41 within virus particles.
        
        
          Methods
          Enzyme-linked immunosorbent assays (ELISA) were used to study CAP binding to HIV-1-sCD4 complexes and to detect gp41 six-helix bundles accessible on virus particles using antibodies specific for the α-helical core domain of gp41.
        
        
          Results
          1) Pretreatment of HIV-1 with sCD4 augments subsequent binding of CAP; 2) there is synergism between CAP and sCD4 for inhibition of HIV-1 infection; 3) treatment of HIV-1 with CAP induced the formation of gp41 six-helix bundles.
        
        
          Conclusions
          CAP and sCD4 bind to distinct sites on HIV-1 IIIB and BaL virions and their simultaneous binding has profound effects on virus structure and infectivity. The formation of gp41 six-helical bundles, induced by CAP, is known to render the virus incompetent for fusion with target cells thus preventing infection.

Tags: cellulose-acetate-phthalate, gp41-six-helix, hiv-1-inhibition, nih, soluble-cd4
Organization: U.S. Department of Health & Human Services
Attitudes of Mexican anesthesiologists to indicate preoperative fasting periods: A cross-sectional survey

Background
          In Mexico, guidelines for fasting periods, or any audits on this topic are unavailable, and therefore the attitudes of anesthesiologists for recommending preoperative fasting periods are unknown.
        
        
          Material and methods
          The study was a cross-sectional survey of anesthesiologists subscribed to the Annual Updated Course, organized by the Sociedad Mexicana de Anestesiologia in 2000. The response rate was 31.4%.
        
        
          Results
          Most respondents were general anesthesiologists, with 5 or more years experience in a clinical post, were working in both public and private hospitals, and were performing anesthetic procedures on both pediatric and adult patients and in both ambulatory and hospitalized patients. Approximately 23% of the respondents considered natural fruit juices to be clear liquids. For a pediatric patient ingesting breast milk 1 h before undergoing a surgical procedure, 45% thought that surgery should be delayed for 3h, followed by those delaying the surgical procedure for 6 to 8 h. Our results show that more than 50% of the anesthesiologists had better defined attitudes for fasting milk and clear liquids in patients of 6 month or under than for older children and adults. However, due to the poor definition or pre-operative fasting, using clear liquids, in all other patient groups, several patients are allowed to go without oral clear liquids administration for prolonged periods.
        
        
          Conclusion
          Preoperative fasting periods recommended by Mexican anesthesiologists differ from international guidelines.

Tags: anesthesiologist-attitudes, cross-sectional-survey, mexican-anesthesiology, nih, preoperative-fasting
Organization: U.S. Department of Health & Human Services
The F-box protein SKP2 mediates androgen control of p27 stability in LNCaP human prostate cancer cells

Background
          The cyclin-dependent kinase inhibitor p27 is a putative tumor suppressor that is downregulated in the majority of human prostate cancers. The mechanism of p27 down-regulation in prostate cancers in unknown, but presumably involves increased proteolysis mediated by the SCFSKP2 ubiquitin ligase complex. Here we used the human prostate cancer cell line LNCaP, which undergoes G1 cell cycle arrest in response to androgen, to examine the role of the SKP2 F-box protein in p27 regulation in prostate cancer.
        
        
          Results
          We show that androgen-induced G1 cell cycle arrest of LNCaP cells coincides with inhibition of cyclin-dependent kinase 2 activity and p27 accumulation caused by reduced p27 ubiquitylation activity. At the same time, androgen decreased expression of SKP2, but did not affect other components of SCFSKP2. Adenovirus-mediated overexpression of SKP2 led to ectopic down-regulation of p27 in asynchronous cells. Furthermore, SKP2 overexpression was sufficient to overcome p27 accumulation in androgen arrested cells by stimulating cellular p27 ubiquitylation activity. This resulted in transient activation of CDK2 activity, but was insufficient to override the androgen-induced G1 block.
        
        
          Conclusions
          Our studies suggest that SKP2 is a major determinant of p27 levels in human prostate cancer cells. Based on our in vitro studies, we suggest that overexpression of SKP2 may be one of the mechanisms that allow prostate cancer cells to escape growth control mediated by p27. Consequently, the SKP2 pathway may be a suitable target for novel prostate cancer therapies.

Tags: androgen-regulation, nih, p27-protein, prostate-cancer, skp2-protein
Organization: U.S. Department of Health & Human Services
Chronic obstructive pulmonary disease, asthma and protective effects of food intake: from hypothesis to evidence?

Evidence for a role of diet in asthma and chronic obstructive pulmonary disease (COPD) has been accumulating rapidly over the past decade. Associations have been reported between the intake of fruit, fish, antioxidant vitamins, fatty acids, sodium or magnesium, and indicators of asthma and COPD. Several issues need to be addressed before causality of these associations can be established. The role of diet in the development of disease and the induction time and reversibility of the effect needs further investigation. The role of smoking habits in the relation of diet and respiratory disease also needs to be elucidated. Nevertheless, based on the available evidence, dietary guidelines could be proposed for the primary and secondary prevention of asthma and COPD that are in line with existing dietary guidelines for the prevention of coronary heart disease and cancer.

Tags: asthma-diet, copd, dietary-intake, nih, pulmonary-disease
Organization: U.S. Department of Health & Human Services
Melatonin reduces TNF-a induced expression of MAdCAM-1 via inhibition of NF-kB.

Background
          Endothelial MAdCAM-1 (mucosal addressin cell adhesion molecule-1) expression is associated with the oxidant-dependent induction and progress of inflammatory bowel disease (IBD). Melatonin, a relatively safe, potent antioxidant, has shown efficacy in several chronic injury models may limit MAdCAM-1 expression and therefore have a therapeutic use in IBD.
        
        
          Methods
          We examined how different doses of melatonin reduced endothelial MAdCAM-1 induced by TNF-a in an in vitro model of lymphatic endothelium. Endothelial monolayers were pretreated with melatonin prior to, and during an exposure, to TNF-a (1 ng/ml, 24 h), and MAdCAM-1 expression measured by immunoblotting.
        
        
          Results
          MAdCAM-1 was induced by TNF-a. Melatonin at concentrations over 100 μm (10-4 M) significantly attenuated MAdCAM-1 expression and was maximal at 1 mM.
        
        
          Conclusions
          Our data indicate that melatonin may exert therapeutic activity in IBD through its ability to inhibit NF-kB dependent induction of MAdCAM-1.

Tags: inflammatory-bowel-disease, madcam-1-expression, melatonin-treatment, nih, tnf-alpha
Organization: U.S. Department of Health & Human Services
2019 Uniform Reporting System (URS) Table for North Carolina

These are the 2019 Uniform Reporting System (URS) Output Tables for North Carolina. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: evidence-based-practices, mental-health-services, national-outcome-measures, samhsa, utilization-measures
Organization: U.S. Department of Health & Human Services
National Estimates of Drug-Related Emergency Department Visits, 2004-2011 - All Misuse and Abuse

Excel file with national estimates, rates, relative standard errors, trends and confidence intervals for all drug-related emergency department (ED) visits involving drug misuse or abuse, covering 2004-2011. Drug misuse/abuse visits include the use of illicit drugs, nonmedical use of pharmaceuticals, underage drinking and visits where alcohol was combined with another drug.

Tags: drug-misuse, drug-related-ed-visits, emergency-department, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
Compound 525340: 1,3-Dithiepane

Chemical compound data from PubChem database. IUPAC Name: 1,3-dithiepane. Molecular Formula: C5H10S2. Molecular Weight: 134.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Interagency Collaboration to Address Human Trafficking

This Child Welfare Information Gateway Podcast is available on Apple Podcasts
  
  

, GooglePlay
  
  

, Spotify
  
  

, Stitcher
  
  

, SoundCloud
  
  

, and the Child Welfare Information Gateway
  
  

 website. Subscribe to receive new episodes as they are released.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: child, human, metadata, podcast, welfare
Organization: U.S. Department of Health & Human Services
Compound 528356: Hexadecyl 6-methylheptanoate

Chemical compound data from PubChem database. IUPAC Name: hexadecyl 6-methylheptanoate. Molecular Formula: C24H48O2. Molecular Weight: 368.6. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Changes in cytokine production in healthy subjects practicing Guolin Qigong : a pilot study

Background
          Guolin Qigong is a combination of meditation, controlled breathing and physical movement designed to control the vital energy (qi) of the body and consequently to improve spiritual, physical and mental health. Practice of Qigong has been reported to alter immunological function, but there have been few studies of its effects on cytokines, the key regulators of immunity.
        
        
          Methods
          Numbers of peripheral blood cytokine-secreting cells were determined by ELISPOT in 19 healthy volunteers aged 27 – 55, before they were taught the practice of Qigong and after 3, 7 and 14 weeks of daily practice. The effect of Qigong on blood cortisol was also examined.
        
        
          Results
          Numbers of IL4 and IL12-secreting cells remained stable. IL6 increased at 7 weeks and TNFα increased in unstimulated cultures at 3 and 7 weeks but decreased at these times in LPS and SAC-stimulated cultures. Of particular interest, IFNγ-secreting cells increased and IL10-secreting cells decreased in PHA-stimulated cultures, resulting in significant increases in the IFNγ:IL10 ratio. Cortisol, a known inhibitor of type 1 cytokine production, was reduced by practicing Qigong.
        
        
          Conclusion
          These preliminary studies in healthy subjects, although not necessarily representative of a randomized healthy population and not including a separate control group, have indicated that blood levels of the stress-related hormone cortisol may be lowered by short-term practice of Qigong and that there are concomitant changes in numbers of cytokine-secreting cells. Further studies of the effect of Qigong in patients with clinical diseases known to be associated with type 2 cytokine predominance are merited.

Tags: cytokine-production, elispot-assay, guolin-qigong, immune-response, nih
Organization: U.S. Department of Health & Human Services
Development of dengue virus replicons expressing HIV-1 gp120 and other heterologous genes: a potential future tool for dual vaccination against dengue virus and HIV

Background
          Toward the goals of providing an additional vector to add to the armamentarium available to HIV vaccinologists and of creating a bivalent vaccine effective against dengue virus and HIV, we have attempted to create vectors which express dengue virus non-structural proteins and HIV immunogens. Previously we reported the successful construction of dengue virus replicons which lack structural genes necessary for virion release and spreading infection in culture but which can replicate intracellularly and abundantly produce dengue non-structural proteins. Here we attempted to express heterologous genetic material from these replicons.
        
        
          Results
          We cloned into a Δpre-M/E dengue virus replicon genes for either green fluorescent protein (GFP), HIV gp160 or HIV gp120 and tested the ability of these constructs to express dengue virus proteins as well as the heterologous proteins in tissue culture after transfection of replicon RNA.
        
        
          Conclusions
          Heterologous proteins were readily expressed from these constructs. GFP and gp120 demonstrated minimal or no toxicity. Gp160 expressing replicons were found to express proteins abundantly at 36 hours post transfection, but after 50 hrs of transfection, few replicon positive cells could be found despite the presence of cellular debris positive for replicon proteins. This suggested that gp160 expressed from dengue virus replicons is considerably more toxic than either GFP or gp120. The successful expression of heterologous proteins, including HIV gp120 for long periods in culture suggests this vector system may be useful as a vaccine vector, given appropriate delivery methods.

Tags: dengue-virus, gp120-expression, hiv-vaccine, nih, viral-replicon
Organization: U.S. Department of Health & Human Services
2012 Uniform Reporting System (URS) Tables for Wisconsin

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2012. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-program, community-mental-health, mental-health-services, outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
2014 CMHS Uniform Reporting System (URS) Table for Indiana

2014 Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for Indiana. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, national-outcome-measures, samhsa, urs-data
Organization: U.S. Department of Health & Human Services
Prenatal diagnosis of Caudal Regression Syndrome : a case report

Background
          Caudal regression is a rare syndrome which has a spectrum of congenital malformations ranging from simple anal atresia to absence of sacral, lumbar and possibly lower thoracic vertebrae, to the most severe form which is known as sirenomelia. Maternal diabetes, genetic predisposition and vascular hypoperfusion have been suggested as possible causative factors.
        
        
          Case presentation
          We report a case of caudal regression syndrome diagnosed in utero at 22 weeks' of gestation. Prenatal ultrasound examination revealed a sudden interruption of the spine and "frog-like" position of lower limbs. Termination of pregnancy and autopsy findings confirmed the diagnosis.
        
        
          Conclusion
          Prenatal ultrasonographic diagnosis of caudal regression syndrome is possible at 22 weeks' of gestation by ultrasound examination.

Tags: caudal-regression-syndrome, congenital-malformations, nih, prenatal-diagnosis, ultrasonography
Organization: U.S. Department of Health & Human Services
Treatment of established postoperative nausea and vomiting: a quantitative systematic review

Background
          The relative efficacy of antiemetics for the treatment of postoperative nausea and vomiting (PONV) is poorly understood.
        
        
          Methods
          Systematic search (MEDLINE, Embase, Cochrane Library, bibliographies, any language, to 8.2000) for randomised comparisons of antiemetics with any comparator for the treatment of established PONV. Dichotomous data on prevention of further nausea and vomiting, and on side effects were combined using a fixed effect model.
        
        
          Results
          In seven trials (1,267 patients), 11 different antiemetics were tested without placebos; these data were not further analysed. Eighteen trials (3,809) had placebo controls. Dolasetron 12.5–100 mg, granisetron 0.1–3 mg, tropisetron 0.5–5 mg, and ondansetron 1–8 mg prevented further vomiting with little evidence of dose-responsiveness; with all regimens, absolute risk reductions compared with placebo were 20%–30%. The anti-nausea effect was less pronounced. Headache was dose-dependent. Results on propofol were contradictory. The NK1 antagonist GR205171, isopropyl alcohol vapor, metoclopramide, domperidone, and midazolam were tested in one trial each with a limited number of patients.
        
        
          Conclusions
          Of 100 vomiting surgical patients receiving a 5-HT3 receptor antagonist, 20 to 30 will stop vomiting who would not have done so had they received a placebo; less will profit from the anti-nausea effect. There is a lack of evidence for a clinically relevant dose-response; minimal effective doses may be used. There is a discrepancy between the plethora of trials on prevention of PONV and the paucity of trials on treatment of established symptoms. Valid data on the therapeutic efficacy of classic antiemetics, which have been used for decades, are needed.

Tags: antiemetic-treatment, nih, ponv-treatment, postoperative-nausea, systematic-review
Organization: U.S. Department of Health & Human Services
Blood substitutes: Haemoglobin therapeutics in clinical practice

Early approaches to the development of oxygen carriers involved the			 use of stroma-free hemoglobin solutions. These solutions did not require blood			 typing or crossmatching and could be stored for long periods. In addition, a			 variety of methods have been developed in chemically modifying and stabilizing			 the hemoglobin molecule. Several hemoglobin therapeutics are now in clinical			 trials as temporary alternatives to blood or as therapeutic agents for			 ischemia. The various hemoglobin products under development are derived from			 three principal sources: human, bovine and genetically engineered hemoglobin.			 Diaspirin cross-linked hemoglobin (DCLHb), administered at doses ranging from			 approximately 20-1000 ml, has been investigated in a number of clinical trials			 in patients undergoing orthopedic, abdominal aortic repair, major abdominal			 surgery, cardiac surgery and in critically ill patients with septic shock. In			 several studies, DCLHb was effective in avoiding the transfusion. However,			 Baxter Healthcare Corporation (Chicago, Illinois, USA) stopped the development			 of DCLHb after two unsuccessful trials in trauma patients. Bovine polymerized			 hemoglobin has also been extensively studied. Several phase II and phase III			 trials have been performed with this product in hemorrhagic surgery, cardiac			 surgery and vascular surgery, but data have not yet been published. Hemoglobin			 therapeutics could provide an important new option as an alternative to blood			 transfusion. Furthermore, they may be able to provide an immediate on-site			 replacement for traumatic blood loss, prevent global ischemia and organ			 failure, treat focal ischemia, and provide effective hemodynamic support for			 septic shock-induced hypotension.

Tags: blood-substitutes, dclhb, hemoglobin-therapeutics, nih, oxygen-carriers
Organization: U.S. Department of Health & Human Services
Antiplatelet and anticoagulant therapy in elective percutaneous coronary intervention

Thrombosis plays a major role in acute vessel closure both after coronary balloon angioplasty and after stenting. This review will address the role of antiplatelet and anticoagulant therapy in preventing early thrombotic complications after percutaneous coronary intervention. The focus will be on agents that are routinely available and commonly used.

Tags: anticoagulant-therapy, antiplatelet-therapy, coronary-intervention, nih, thrombosis-prevention
Organization: U.S. Department of Health & Human Services
The National Survey of Child and Adolescent Well-Being I (NSCAW I), General Release, Waves 1-5

The target population for the NSCAW includes all children and families that enter the child welfare system. Two samples were drawn from the population in 92 participating county child welfare agencies throughout the nation. The CPS sample includes 5,501 children, who were between the ages of 0 and 14 years at the close of the investigation. All investigations for the sample were closed between October 1, 1999 and December 31, 2000. The second sample consists of an additional 727 children, who were in out-of-home care for about 12 months at the time of sampling. This second group, referred to as the One Year in Foster Care (OYFC) Sample, was selected to allow special analysis related to the experience of out-of-home care. Waves 2, 3, and 4 take place 12, 18, and 36 months after the close of the investigation.

Investigators: Research Triangle Institute

Tags: abuse, care, ndacan, policy, reporting
Organization: U.S. Department of Health & Human Services
2021 Uniform Reporting System (URS) Table For Wyoming

This is the 2021 Uniform Reporting System (URS) Output Tables for Wyoming. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, evidence-based-practices, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services