AndreaBozzo/ceres-open-data-index huggingface dataset:
How should an infected perinephric haematoma be drained in a tetraplegic patient with baclofen pump implanted in the abdominal wall? – A case report

Background
          We present a case to illustrate controversies in percutaneous drainage of infected, perinephric haematoma in a tetraplegic patient, who had implantation of baclofen pump in anterior abdominal wall on the same side as perinephric haematoma.
        
        
          Case presentation
          A 56-year-old male with C-4 tetraplegia had undergone implantation of programmable pump in the anterior abdominal wall for intrathecal infusion of baclofen to control spasticity. He developed perinephric haematoma while he was taking warfarin as prophylactic for deep vein thrombosis. Perinephric haematoma became infected with a resistant strain of Pseudomonas aeruginosa, and required percutaneous drainage. Positioning this patient on his abdomen without anaesthesia, for insertion of a catheter from behind, was not a realistic option. Administration of general anaesthesia in this patient in the radiology department would have been hazardous.
        
        
          Results and Conclusion
          Percutaneous drainage was carried out by anterior approach under propofol sedation. The site of entry of percutaneous catheter was close to cephalic end of baclofen pump. By carrying out drainage from anterior approach, and by keeping this catheter for ten weeks, we took a risk of causing infection of the baclofen pump site, and baclofen pump with a resistant strain of Pseudomonas aeruginosa. The alternative method would have been to anaesthetise the patient and position him prone for percutaneous drainage of perinephric collection from behind. This would have ensured that the drainage track was far away from the baclofen pump with minimal risk of infection of baclofen pump, but at the cost of incurring respiratory complications in a tetraplegic subject.

Tags: baclofen-pump, nih, perinephric-hematoma, pseudomonas-aeruginosa, tetraplegia
Organization: U.S. Department of Health & Human Services
Compound 528544: Hexadecane, 8-hexyl

Chemical compound data from PubChem database. IUPAC Name: 8-hexylhexadecane. Molecular Formula: C22H46. Molecular Weight: 310.6. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Utah, 2014

This is a behavioral health report for the state of Utah. It uses the  National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment Services (NSSATS) to address the topics of youth substance use , youth mental health and treatment, adult mental health and treatment, substance use, substance use treatment, and medicare enrollees for the years 2009 to 2013.

Tags: mental-health-utah, samhsa, substance-use-utah, utah-behavioral-health, youth-mental-health
Organization: U.S. Department of Health & Human Services
Mannosylerythritol lipid, a yeast extracellular glycolipid, shows high binding affinity towards human immunoglobulin G

Background
          There have been many attempts to develop new materials with stability and high affinity towards immunoglobulins. Some of glycolipids such as gangliosides exhibit a high affinity toward immunoglobulins. However, it is considerably difficult to develop these glycolipids into the practical separation ligand due to their limited amounts. We thus focused our attention on the feasible use of "mannosylerythritol lipid A", a yeast glycolipid biosurfactant, as an alternative ligand for immunoglobulins, and undertook the investigation on the binding between mannosylerythritol lipid A (MEL-A) and human immunoglobulin G (HIgG).
        
        
          Results
          In ELISA assay, MEL-A showed nearly the same binding affinity towards HIgG as that of bovine ganglioside GM1. Fab of human IgG was considered to play a more important role than Fc in the binding of HIgG by MEL-A. The bound amount of HIgG increased depending on the attached amount of MEL-A onto poly (2-hydroxyethyl methacrylate) (polyHEMA) beads, whereas the amount of human serum albumin slightly decreased. Binding-amount and -selectivity of HIgG towards MEL-A were influenced by salt species, salt concentration and pH in the buffer solution. The composite of MEL-A and polyHEMA, exhibited a significant binding constant of 1.43 × 106 (M-1) for HIgG, which is approximately 4-fold greater than that of protein A reported.
        
        
          Conclusions
          MEL-A shows high binding-affinity towards HIgG, and this is considered to be due to "multivalent effect" based on the binding molar ratio. This is the first report on the binding of a natural human antibody towards a yeast glycolipid.

Tags: biosurfactant, glycolipid-affinity, igg-binding, mannosylerythritol-lipid, nih
Organization: U.S. Department of Health & Human Services
Compound 528469: 1-Tridecene, 9-methyl

Chemical compound data from PubChem database. IUPAC Name: 9-methyltridec-1-ene. Molecular Formula: C14H28. Molecular Weight: 196.37. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Kefir consumption does not alter plasma lipid levels or cholesterol fractional synthesis rates relative to milk in hyperlipidemic men: a randomized controlled trial [ISRCTN10820810]

Background
          Fermented milk products have been shown to affect serum cholesterol concentrations in humans. Kefir, a fermented milk product, has been traditionally consumed for its potential health benefits but has to date not been studied for its hypocholesterolemic properties.
        
        
          Methods
          Thirteen healthy mildly hypercholesterolemic male subjects consumed a dairy supplement in randomized crossover trial for 2 periods of 4 wk each. Subjects were blinded to the dairy supplement consumed. Blood samples were collected at baseline and after 4 wk of supplementation for measurement of plasma total, low-density lipoprotein, and high-density lipoprotein cholesterol and triglyceride concentrations, as well as fatty acid profile and cholesterol synthesis rate. Fecal samples were collected at baseline and after 2 and 4 wk of supplementation for determination of fecal short chain fatty acid level and bacterial content.
        
        
          Results
          Kefir had no effect on total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglyceride concentrations nor on cholesterol fractional synthesis rates after 4 wk of supplementation. No significant change on plasma fatty acid levels was observed with diet. However, both kefir and milk increased (p < 0.05) fecal isobutyric, isovaleric and propionic acids as well as the total amount of fecal short chain fatty acids. Kefir supplementation resulted in increased fecal bacterial content in the majority of the subjects.
        
        
          Conclusions
          Since kefir consumption did not result in lowered plasma lipid concentrations, the results of this study do not support consumption of kefir as a cholesterol-lowering agent.

Tags: cholesterol-synthesis, hyperlipidemia, kefir-consumption, lipid-levels, nih
Organization: U.S. Department of Health & Human Services
Compound 527381: 20-Methyl-hentriacontyl cyanide

Chemical compound data from PubChem database. IUPAC Name: 21-methyldotriacontanenitrile. Molecular Formula: C33H65N. Molecular Weight: 475.9. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Hypothesis to explain poor outcomes in the ALLHAT and V-HeFT trials: decreased expression of heat shock proteins

An explanation for the higher incidence of cardiovascular disease and heart failure in the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) with doxazosin and the Vasodilator Heart Failure Trial (V-HeFT) with prazosin might be decreased expression of heat shock proteins. Heat shock proteins help to protect cells from ischemic injury by decreasing oxidation, suppressing cytokine action, refolding damaged proteins, and decreasing apoptosis. I hypothesize that α-adrenergic blockade decreases heat shock protein levels, thus making the heart and vascular system vulnerable to injury from pathologic processes such as ischemia, hypertension, oxidation or inflammation. Similarly, poor cardiovascular outcomes with calcium-channel blockers might be due to decreased expression of heat shock proteins.

Tags: alpha-adrenergic-blockade, cardiovascular-outcomes, clinical-trials, heat-shock-proteins, nih
Organization: U.S. Department of Health & Human Services
The use of alternative therapies in the Saskatchewan stroke rehabilitation population

Background
          Many patients use alternative therapies. The purpose of this study was to determine the percentage of stroke rehabilitation patients in Saskatchewan using alternative therapies, whether patients found these therapies effective in alleviating stroke-related symptoms, how often those patients who used alternative therapies discuss this fact with their primary care doctor and the main reason why patients might not do so.
        
        
          Methods
          Telephone questionnaire surveys were conducted with 117 patients who had suffered a stroke and undergone inpatient or outpatient rehabilitation at Saskatoon City Hospital.
        
        
          Results
          The study revealed that 26.5% of 117 stroke rehabilitation patients visited alternative practitioners at least once or used some form of unconventional therapy. Only 16.1% of patients found that alternative therapy made them feel much better. Of those who used alternative therapy, 61.3% did not discuss this fact with their primary physician. Many of the respondents (47.3%) who did not inform their physician stated that they did not see the necessity of talking about these treatments and 21.1% did not discuss the issue with their physician because they felt that he or she might disapprove of alternative therapies.
        
        
          Conclusion
          A relatively small percentage of stroke patients found alternative therapies beneficial. Doctors should be aware that a significant number of patients will try alternative treatment without discussion with their primary care physician or specialist. The current study suggests that after completing routine questioning, doctors should also ask their patients about their use of alternative therapies and, when appropriate, review issues of safety and efficacy.

Tags: alternative-therapy, nih, patient-survey, saskatchewan, stroke-rehabilitation
Organization: U.S. Department of Health & Human Services
Compound 527321: methyl 2-[5-(4-chlorophenyl)-2-(4-methoxyphenyl)-2H-imidazol-4-yl]acetate

Chemical compound data from PubChem database. IUPAC Name: methyl 2-[5-(4-chlorophenyl)-2-(4-methoxyphenyl)-2H-imidazol-4-yl]acetate. Molecular Formula: C19H17ClN2O3. Molecular Weight: 356.8. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Alcohol and Drug Combinations Are More Likely to Have a Serious Outcome Than Alcohol Alone in Emergency Department Visits Involving Underage Drinking

This Drug Abuse Warning Network (DAWN) spotlight looks at the outcomes of emergency department visits that involve underage drinking in 2011. The report compares the outcome of emergency department vists by patients ages 12-20 that involved alcohol only, to visits where other drug(s) were taken along with alcohol.

Tags: drug-combinations, emergency-department, samhsa, substance-abuse, underage-drinking
Organization: U.S. Department of Health & Human Services
2014 CMHS Uniform Reporting System (URS) Table for Alabama

2014 Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for Alabama. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: alabama-mental-health, community-mental-health, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
14th NCCAN Program Book

The 14th NCCAN program describes abstracts of presentations, list of speakers, and other conference details. Additional content includes welcome letters, biographies, and photos of plenary speakers; acknowledgements; an exhibitor list; and general conference information.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: child, policy, program, social, summary
Organization: U.S. Department of Health & Human Services
NSDUH 2021 Sample Experience Report

This report is a continuation of the 2021National Survey on Drug Use and Health (NSDUH) Sample Design Report. It further documents the 2021 NSDUH sample experiences, by comparing expected outcomes with what actually occurred, and documenting unexpected issues that came up during the year. The report also summarizes the information about the sample design that is more thoroughly detailed in the previous report.Chapter 1 introduces the report and summarizes the impact of the coronavirus 2019 pandemic on the sample design and data collection. Chapter 2 revisits the 2021 sample design. Chapters 3, 4, and 5 document the sample experiences at the third, fourth, and fifth stages of sample selection, respectively. Finally, Chapter 6 compares the observed and expected precisions, and also examines trends in average design effects over time.The document is available as a PDF.

Tags: design-effects, mental-health, samhsa, substance-use, survey-sampling
Organization: U.S. Department of Health & Human Services
Compound 527316: Methyl 2-[5-methoxy-1-(4-methoxybenzoyl)-2-methylindol-3-yl]acetate

Chemical compound data from PubChem database. IUPAC Name: methyl 2-[5-methoxy-1-(4-methoxybenzoyl)-2-methylindol-3-yl]acetate. Molecular Formula: C21H21NO5. Molecular Weight: 367.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 527226: 1-((1S,2R,3R)-2-(3-Isopropylfuran-2-yl)-3-methylcyclopentyl)ethanone

Chemical compound data from PubChem database. IUPAC Name: 1-[3-methyl-2-(3-propan-2-ylfuran-2-yl)cyclopentyl]ethanone. Molecular Formula: C15H22O2. Molecular Weight: 234.33. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Functional associations of proteins in entire genomes by means of exhaustive detection of gene fusions

Background
          It has recently been shown that the detection of gene fusion events across genomes can be used for predicting functional associations of proteins, including physical interaction or complex formation. To obtain such predictions we have made an exhaustive search for gene fusion events within 24 available completely sequenced genomes.
        
        
          Results
          Each genome was used as a query against the remaining 23 complete genomes to detect gene fusion events. Using an improved, fully automatic protocol, a total of 7,224 single-domain proteins that are components of gene fusions in other genomes were detected, many of which were identified for the first time. The total number of predicted pairwise functional associations is 39,730 for all genomes. Component pairs were identified by virtue of their similarity to 2,365 multidomain composite proteins. We also show for the first time that gene fusion is a complex evolutionary process with a number of contributory factors, including paralogy, genome size and phylogenetic distance. On average, 9% of genes in a given genome appear to code for single-domain, component proteins predicted to be functionally associated. These proteins are detected by an additional 4% of genes that code for fused, composite proteins.
        
        
          Conclusions
          These results provide an exhaustive set of functionally associated genes and also delineate the power of fusion analysis for the prediction of protein interactions.

Tags: gene-fusion, genomic-analysis, nih, protein-associations, protein-interaction
Organization: U.S. Department of Health & Human Services
2022 Uniform Reporting System (URS) Table For Ohio

This is the 2022 Uniform Reporting System (URS) Output Tables for Ohio. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant, mental-health-services, ohio, outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
2012 Uniform Reporting System (URS) Tables for Nebraska

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2012. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, national-outcome-measures, nebraska-mental-health, samhsa
Organization: U.S. Department of Health & Human Services
Single session endoscopic management of intrinsic ureteropelvic junction obstruction and concomitant renal stone disease in a child: a case report

Background
          Percutaneous nephrolithotomy is a well known therapeutic modality for stone diseases of childhood. Antegrade and retrograde endopyelotomies are also well defined options of treatment for secondary ureteropelvic junction obstruction. Yet there are few reports regarding endoscopic therapy of intrinsic ureteropelvic junction obstruction. To our knowledge, there exist only a few reports of endosurgical treatment of children with stone disease and with concomitant intrinsic ureteropelvic junction obstruction, in the literature.
        
        
          Case presentation
          We present the endoscopic management of stone disease and concomitant intrinsic ureteropelvic junction obstruction of a child in one session.
        
        
          Conclusion
          Percutaneous nephrolithotomy and antegrade endopyelotomy is combined safely with successful outcome in a child.

Tags: endopyelotomy, kidney-stones, nih, pediatric-urology, ureteropelvic-junction-obstruction
Organization: U.S. Department of Health & Human Services
NSDUH 2023 Methodological Resource Book (MRB)

Use this collection to provide context for estimates from the National Survey on Drug Use and Health (NSDUH). This collection includes materials used to conduct the survey, reports on how the survey was conducted, and reports on how the data were processed. The Statistical Inference Report details how the data were analyzed for reports and tables, which may be useful for data users looking to do their own analysis.New items are added to the collection as they become available, so resources published in a previous MRB may not yet be available for 2023. However, there are generally few changes from year to year, and a report from a previous year may have the information you are looking for.

Tags: data-analysis, mental-health, samhsa, substance-use, survey-methodology
Organization: U.S. Department of Health & Human Services
Compound 525525: (3-Chloro-4-cyclohexylmethoxy-phenyl)-acetic acid, methyl ester

Chemical compound data from PubChem database. IUPAC Name: methyl 2-[3-chloro-4-(cyclohexylmethoxy)phenyl]acetate. Molecular Formula: C16H21ClO3. Molecular Weight: 296.79. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2010 State Profile — Pennsylvania

This state profile includes data from facilities in Pennsylvania that reported to N-SSATS for the survey reference date March 31, 2010. Data were collected on the location, characteristics, services offered, and number of clients in treatment at alcohol and drug abuse treatment facilities (both public and private) in Pennsylvania. In Pennsylvania, 533 substance abuse treatment facilities were included in the 2010 N-SSATS, reporting that there were 51,302 clients in substance abuse treatment on March 31, 2010. The survey response rate in Pennsylvania was 93.4%.

Tags: addiction-services, n-ssats, pennsylvania, samhsa, substance-abuse-treatment
Organization: U.S. Department of Health & Human Services
New York City – 5 Boros: Drug-Related Emergency Department Visits, 2004-2011 - All Alcohol

Excel file with estimates, rates, relative standard errors, trends and confidence intervals, covering 2004-2011 for emergency department visits involving alcohol in New York City (5 boroughs).  For adults aged 21 and older, the alcohol was found in combination with other drugs. For patients under the age of 21, the visit may involve alcohol alone or in combination with other drugs.File includes data for over 500 drugs, including illicit drugs, prescription and over-the-counter medications, dietary supplements, inhalants and alcohol.  Includes total visits, gender, age group, race/ethnicity, outcome of visit, drug combinations, number of drugs involved in visit, drug frequency, and drugs confirmed by toxicology.Additional detail is provided for illicit drugs, psychotherapeutic drugs, central nervous system (CNS) drugs, respiratory drugs and cardiovascular drugs.

Tags: alcohol-drug-combinations, alcohol-related-ed-visits, nyc-emergency-department, samhsa, substance-abuse-trends
Organization: U.S. Department of Health & Human Services
Bone loss: Therapeutic approaches for preventing bone loss in inflammatory arthritis

Inflammatory arthritides are commonly characterized by localized and generalized bone loss. Localized bone loss in the form of joint erosions and periarticular osteopenia is a hallmark of rheumatoid arthritis, the prototype of inflammatory arthritis. Recent studies have highlighted the importance of receptor activator of nuclear factor-κB ligand (RANKL)-dependent osteoclast activation by inflammatory cells and subsequent bone loss. In this article, we review the pathogenesis of inflammatory bone loss and explore the possible therapeutic interventions to prevent it.

Tags: bone-loss, inflammatory-arthritis, nih, osteopenia, rheumatoid-arthritis
Organization: U.S. Department of Health & Human Services