AndreaBozzo/ceres-open-data-index huggingface dataset:
Thrombospondin 2 Inhibits Microvascular Endothelial Cell
Proliferation by a Caspase-independent Mechanism

The matricellular protein thrombospondin 2 (TSP2) regulates a
variety of cell–matrix interactions. A prominent feature of TSP2-null
mice is increased microvascular density, particularly in connective
tissues synthesized after injury. We investigated the cellular basis
for the regulation of angiogenesis by TSP2 in cultures of murine and
human fibroblasts and endothelial cells. Fibroblasts isolated from
murine and human dermis synthesize TSP2 mRNA and secrete significant
amounts of immunoreactive TSP2, whereas endothelial cells from mouse
lung and human dermis did not synthesize TSP2 mRNA or protein.
Recombinant mouse TSP2 inhibited growth of human microvascular
endothelial cells (HMVECs) mediated by basic fibroblast growth factor,
insulin-like growth factor-1, epidermal growth factor, and vascular
endothelial growth factor (VEGF). HMVECs exposed to TSP2 in the
presence of these growth factors had a decreased proportion of cells in
S and G2/M phases. HMVECs cultured with a combination of
basic fibroblast growth factor, insulin-like growth factor-1, and
epidermal growth factor displayed an increased proportion of nonviable
cells in the presence of TSP2, but the addition of VEGF blocked this
TSP2-mediated impairment of cell viability. TSP2-mediated inhibition of
DNA synthesis by HMVECs in the presence of VEGF was not affected by the
broad-spectrum caspase inhibitor zVAD-fmk. Similar findings were
obtained with TSP1. Taken together, these observations indicate that
either TSP2 or TSP1 can inhibit HMVEC proliferation by inhibition of
cell cycle progression and induction of cell death, but the mechanisms
responsible for TSP2-mediated inhibition of cell cycle progression are
independent from those leading to cell death.

Tags: angiogenesis-inhibition, endothelial-cell-proliferation, microvascular-density, nih, thrombospondin-2
Organization: U.S. Department of Health & Human Services
2015 CMHS Uniform Reporting System (URS) Table for Idaho

2015 Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for Idaho. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant, idaho, mental-health-services, outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
NSDUH 2023 Sample Design Report

Learn about the sample design used for the 2023 National Survey on Drug Use and Health (NSDUH). The report describes the five stages of sample selection, sample weighting and variance estimation procedures, and the Mental Illness Calibration Study sample design.Chapters:Introduces the report, describes the target population, and provides a general overview of the 2023 NSDUH sample design.Summarizes the 2014 through 2023 coordinated sample design.Discusses the first three stages of selection in greater detail.Describes the 2023 NSDUH hybrid field enumeration and address-based sampling frame.Discusses the fourth and fifth stages of selection.Describes sample weighting and variance estimation procedures for 2023.Summarizes the sample design for the Mental Illness Calibration Study.

Tags: mental-illness-calibration, nsduh-sample-design, samhsa, substance-use-survey, survey-methodology
Organization: U.S. Department of Health & Human Services
Correlates of Lifetime Exposure to One or More Potentially Traumatic Events and Subsequent Posttraumatic Stress among Adults in the United States: Results from the Mental Health Surveillance Study, 2008-2012

With growing recognition of the impact of trauma exposure on behavioral health outcomes, the Substance Abuse and Mental Health Services Administration (SAMHSA) is interested in evaluating associations between potentially traumatic events (PTEs) with mental health and substance use issues. The 2008-2012 National Survey on Drug Use and Health (NSDUH) Mental Health Surveillance Study (MHSS) defined and measured posttraumatic stress disorder (PTSD) as part of an effort to estimate serious mental illness among adults in the U.S. civilian, noninstitutionalized population. The module on PTSD collected as part of the MHSS can be used to measure lifetime exposure to one or more PTEs, as well as subsequent posttraumatic stress symptoms (PTSS), including symptom clusters that meet criteria for past year PTSD among adults. This report uses NSDUH and MHSS data to study the association among PTEs, PTSS, and physical and behavioral health conditions.

Tags: mental-health-surveillance, ptsd-symptoms, samhsa, substance-use, traumatic-events
Organization: U.S. Department of Health & Human Services
2012 Uniform Reporting System (URS) Tables for Rhode Island

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2012. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: mental-health-services, outcome-measures, rhode-island, samhsa, utilization-data
Organization: U.S. Department of Health & Human Services
2011 CMHS Uniform Reporting System (URS) Output Tables for New York

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2011. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, national-outcome-measures, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
Polycystic kidney disease in patients on the renal transplant waiting list: trends in hematocrit and survival

Background
          The patient characteristics and mortality associated with autosomal dominant polycystic kidney disease (PKD) have not been characterized for a national sample of end stage renal disease (ESRD) patients on the renal transplant waiting list.
        
        
          Methods
          40,493 patients in the United States Renal Data System who were initiated on ESRD therapy between 1 April 1995 and 29 June 1999 and later enrolled on the renal transplant waiting list were analyzed in an historical cohort study of the relationship between hematocrit at the time of presentation to ESRD and survival (using Cox Regression) in patients with PKD as a cause of ESRD.
        
        
          Results
          Hematocrit levels at presentation to ESRD increased significantly over more recent years of the study. Hematocrit rose in parallel in patients with and without PKD, but patients with PKD had consistently higher hemoglobin. PKD was independently associated with higher hematocrit in multiple linear regression analysis (p < 0.0001). In logistic regression, higher hematocrit was independently associated with PKD. In Cox Regression analysis, PKD was associated with statistically significant improved survival both in comparison with diabetic (hazard ratio, 0.64, 95% CI 0.53–0.77, p < 0.001) and non-diabetic (HR 0.68, 95% CI 0.56–0.82, p = 0.001) ESRD patients, adjusted for all other factors.
        
        
          Conclusions
          Hematocrit at presentation to ESRD was significantly higher in patients with PKD compared with patients with other causes of ESRD. The survival advantage of PKD in ESRD persisted even adjusted for differences in hematocrit and in comparison with patients on the renal transplant waiting list.

Tags: esrd-mortality, hematocrit-levels, nih, polycystic-kidney-disease, renal-transplant
Organization: U.S. Department of Health & Human Services
2018 Uniform Reporting System (URS) Table for New Mexico

This is the 2018 Uniform Reporting System (URS) Output Tables for New Mexico. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: behavioral-health, mental-health-services, noms-measures, samhsa, urs-data
Organization: U.S. Department of Health & Human Services
Compound 525469: Disulfide, pentyl propyl

Chemical compound data from PubChem database. IUPAC Name: 1-(propyldisulfanyl)pentane. Molecular Formula: C8H18S2. Molecular Weight: 178.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2023 Uniform Reporting System (URS) Table For Palau

This is the 2023 Uniform Reporting System (URS) Output Tables for Palau. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, national-outcome-measures, palau-health-data, samhsa
Organization: U.S. Department of Health & Human Services
Compound 525131: 1,3-Benzenedicarboxylic acid, dipentyl ester

Chemical compound data from PubChem database. IUPAC Name: dipentyl benzene-1,3-dicarboxylate. Molecular Formula: C18H26O4. Molecular Weight: 306.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2018-2020 NSDUH National Maps of Prevalence Estimates by Substate Region

Substate estimates for these years are no longer available due to methodological concerns with combining 2020 data with data from 2018 and 2019. We apologize for any inconvenience or confusion this may cause.Because of the COVID-19 pandemic, most respondents answered the survey via the web in Quarter 4 of 2020, even though all responses in Quarter 1 were from in-person interviews. It is known that people may respond to the survey differently while taking it online, thus introducing what is called a mode effect.When the state estimates were released, it was assumed that the mode effect was similar for different groups of people. However, later analyses have shown that this assumption should not be made. Because of these analyses, along with concerns about the rapid societal changes in 2020, it was determined that averages across the three years could be misleading.For more detail on this decision, see the 2018-2020substate data page.

Tags: mental-health, prevalence-estimates, samhsa, substance-use, survey-data
Organization: U.S. Department of Health & Human Services
Simpson's paradox and calculation of number needed to treat from meta-analysis

Background
          Calculation of numbers needed to treat (NNT) is more complex from meta-analysis than from single trials. Treating the data as if it all came from one trial may lead to misleading results when the trial arms are imbalanced.
        
        
          Discussion
          An example is shown from a published Cochrane review in which the benefit of nursing intervention for smoking cessation is shown by formal meta-analysis of the individual trial results. However if these patients were added together as if they all came from one trial the direction of the effect appears to be reversed (due to Simpson's paradox).
          Whilst NNT from meta-analysis can be calculated from pooled Risk Differences, this is unlikely to be a stable method unless the event rates in the control groups are very similar. Since in practice event rates vary considerably, the use a relative measure, such as Odds Ratio or Relative Risk is advocated. These can be applied to different levels of baseline risk to generate a risk specific NNT for the treatment.
        
        
          Summary
          The method used to calculate NNT from meta-analysis should be clearly stated, and adding the patients from separate trials as if they all came from one trial should be avoided.

Tags: meta-analysis, nih, number-needed-to-treat, simpsons-paradox, smoking-cessation
Organization: U.S. Department of Health & Human Services
The role of statins as potential targets for bone formation

Inhibitors of the 3-hydroxy-3-methylglutaryl coenzyme A reductase enzyme have recently been shown to stimulate bone formation in rodents both in vitro and in vivo. In bone cells, these inhibitors increase the gene expression of bone morphogenetic protein-2, which is an autocrine-paracrine factor for osteoblast differentiation.
        The findings that statins increase bone formation and bone mass in rodents suggest a potential new action for these compounds, which may be beneficial in patients with established osteoporosis where marked bone loss has occurred. Recent clinical data suggest that they may reduce the risk of fracture in patients taking these drugs.

Tags: bone-formation, hmg-coa-reductase, nih, osteoporosis-treatment, statin-therapy
Organization: U.S. Department of Health & Human Services
Enhanced expression of genes involved in coagulation and fibrinolysis in murine arthritis

We have analyzed the pattern of procoagulant and fibrinolytic gene expression in affected joints during the course of arthritis in two murine models. In both models, we found an increased expression of tissue factor, tissue factor pathway inhibitor, urokinase plasminogen activator, and plasminogen activator inhibitor 1, as well as thrombin receptor. The observed pattern of gene expression tended to favor procoagulant activity, and this pattern was confirmed by functional assays. These alterations would account for persistence of fibrin within the inflamed joint, as is seen in rheumatoid arthritis.

Tags: coagulation-genes, fibrinolysis-genes, murine-arthritis, nih, rheumatoid-arthritis
Organization: U.S. Department of Health & Human Services
Leptin in septic arthritis: decreased levels during infection and amelioration of disease activity upon its administration

Weight loss is typically found during severe infections, e.g. septic arthritis. The aim of our study was to evaluate the role of leptin, regulator of food intake and energy expenditure, for the development of Staphylococcus aureus-triggered arthritis. Leptin production was found to be decreased during murine S. aureus-induced arthritis. Treatment with recombinant leptin neither restored the basal leptin levels nor affected the weight loss during the disease, but it significantly decreased the severity of septic arthritis. Exogenous leptin did not affect the staphylococcal load as measured in blood, joints and kidneys. Preceding the effects on joint manifestations, serum levels of interleukin-6 decreased in leptin-treated mice. In conclusion, the treatment with recombinant leptin reduced both the severity of joint manifestations in S.aureus-induced arthritis and the inflammatory response, as measured by serum IL-6 levels, without affecting the survival of bacteria in vivo.

Tags: il-6, leptin-treatment, nih, septic-arthritis, staphylococcus-aureus
Organization: U.S. Department of Health & Human Services
Compound 528372: Pyroglutamic acid, di-TMS

Chemical compound data from PubChem database. IUPAC Name: trimethylsilyl 5-trimethylsilyloxy-3,4-dihydro-2H-pyrrole-2-carboxylate. Molecular Formula: C11H23NO3Si2. Molecular Weight: 273.48. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Phoenix: Drug-Related Emergency Department Visits, 2004-2011 - All Alcohol

Excel file with estimates, rates, relative standard errors, trends and confidence intervals, covering 2004-2011 for emergency department visits involving alcohol in the Phoenix metropolitan area.  For adults aged 21 and older, the alcohol was found in combination with other drugs. For patients under the age of 21, the visit may involve alcohol alone or in combination with other drugs.File includes data for over 500 drugs, including illicit drugs, prescription and over-the-counter medications, dietary supplements, inhalants and alcohol.  Includes total visits, gender, age group, race/ethnicity, outcome of visit, drug combinations, number of drugs involved in visit, drug frequency, and drugs confirmed by toxicology.Additional detail is provided for illicit drugs, psychotherapeutic drugs, central nervous system (CNS) drugs, respiratory drugs and cardiovascular drugs.

Tags: alcohol-related-ed-visits, drug-combinations, phoenix-metro-area, samhsa, substance-abuse-trends
Organization: U.S. Department of Health & Human Services
Detection and subtyping of Herpes simplex virus in clinical samples by LightCycler PCR, enzyme immunoassay and cell culture

Background
          Prompt laboratory diagnosis of Herpes simplex virus (HSV) infection facilitates patient management and possible initiation of antiviral therapy. In our laboratory, which receives various specimen types for detection of HSV, we use enzyme immunoassay (EIA) for rapid detection and culture of this virus. The culture of HSV has traditionally been accepted as the diagnostic 'gold standard'. In this study, we compared the use of real time PCR (LightCycler) for amplification, detection and subtyping of specific DNA with our in-house developed rapid and culture tests for HSV.
        
        
          Results
          The LightCycler PCR (LC-PCR) detected and subtyped HSV in 99% (66/67) of HSV positive specimens, compared to 81% (54/67) by rapid antigen EIA or 57% (36/63) by culture. A specimen was considered positive when two or more tests yielded HSV identifications or was culture positive. Discordant results were confirmed with an in-house developed PCR-ELISA or DNA sequence analysis. The typing results obtained with the LC-PCR and by culture amplified test were completely concordant.
        
        
          Conclusions
          This study showed that the LC-PCR provided a highly sensitive test for simultaneous detection and subtyping of HSV in a single reaction tube. In addition to increased sensitivity, the LightCycler PCR provided reduced turn-around-times (2 hours) when compared to enzyme immunoassay (4 hours) or culture (4 days).

Tags: enzyme-immunoassay, herpes-simplex-virus, nih, pcr-detection, viral-subtyping
Organization: U.S. Department of Health & Human Services
2011 State Profile — South Carolina

This is a National Survey of Substance Abuse Treatment Services (N-SSATS) data table showing state profiles for South Carolina in 2011. N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 States, the District of Columbia, and other U.S. jurisdictions.

Tags: n-ssats, samhsa, south-carolina, substance-abuse-treatment, treatment-facilities
Organization: U.S. Department of Health & Human Services
Compound 525622: N,N-Dimethyl-N'-decyl-benzamidine

Chemical compound data from PubChem database. IUPAC Name: N'-decyl-N,N-dimethylbenzenecarboximidamide. Molecular Formula: C19H32N2. Molecular Weight: 288.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Connecticut AFCARS Assessment Review

This webpage includes the documentation from Connecticut's Adoption and Foster Care Analysis and Reporting System (AFCARS) assessment review sfor fiscal year 2001:

Case File Findings
  
  

 (PDF) (PDF - 35 KB)

Case File Findings Summary Report
  
  

 (PDF) (PDF - 8 KB)

AFCARS Assessment Review Improvement Plan
  
  

 (PDF) (PDF - 48 KB)

AFCARS Assessment Review Findings
  
  

 (PDF) (PDF - 79 KB)

AFCARS Assessment Improvement Plan - General Requirements
  
  

 (PDF) (PDF - 16 KB)

AFCARS Assessment Review Findings - General Requirements
  
  

 (PDF) (PDF - 28 KB)

Connecticut AFCARS Assessment Report
  
  

 (PDF) (PDF - 42 KB)

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: adoption, assessment, fiscal, foster, reporting
Organization: U.S. Department of Health & Human Services
A simple method for generating full length cDNA from low abundance partial genomic clones

Background
          PCR amplification of target molecules involves sequence specific primers that flank the region to be amplified. While this technique is generally routine, its applicability may not be sufficient to generate a desired target molecule from two separate regions involving intron /exon boundaries. For these situations, the generation of full-length complementary DNAs from two partial genomic clones becomes necessary for the family of low abundance genes.
        
        
          Results
          The first approach we used for the isolation of full-length cDNA from two known genomic clones of Hox genes was based on fusion PCR. Here we describe a simple and efficient method of amplification for homeobox D13 (HOXD13) full length cDNA from two partial genomic clones. Specific 5' and 3' untranslated region (UTR) primer pairs and website program (primer3_www.cgv0.2) were key steps involved in this process.
        
        
          Conclusions
          We have devised a simple, rapid and easy method for generating cDNA clone from genomic sequences. The full length HOXD13 clone (1.1 kb) generated with this technique was confirmed by sequence analysis. This simple approach can be utilized to generate full-length cDNA clones from available partial genomic sequences.

Tags: full-length-cdna, fusion-pcr, genomic-clones, hoxd13-gene, nih
Organization: U.S. Department of Health & Human Services
2023 Uniform Reporting System (URS) Table For Idaho

This is the 2023 Uniform Reporting System (URS) Output Tables for Idaho. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant, idaho, mental-health-services, outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Compound 525332: Trithiacyclohexene

Chemical compound data from PubChem database. IUPAC Name: 3,4-dihydrodithiine. Molecular Formula: C4H6S2. Molecular Weight: 118.2. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services