AndreaBozzo/ceres-open-data-index huggingface dataset:
Primary biliary cirrhosis and autoimmune cholangitis are not associated with coeliac disease in Crete

Background
          An increased prevalence of coeliac disease in patients with primary biliary cirrhosis has been recently reported. However, in other studies the association has not been confirmed. There have been no formal attempts to systematically evaluate patients with autoimmune cholangitis for coeliac disease.
        
        
          Methods
          Sera from 62 patients with primary biliary cirrhosis, 17 with autoimmune cholangitis and 100 blood donors were screened for anti-gliadin, anti-endomysial, anti-reticulin, and IgA class antibodies to guinea pig liver-derived tissue transglutaminase. Eighteen untreated coeliacs served as methodological controls. Analyses were performed by using the χ2 and Fischer's exact tests.
        
        
          Results
          Anti-gliadin antibodies were detected in 21% of patients with primary biliary cirrhosis, 35% of patients with autoimmune cholangitis, and 3% of controls (p < 0.001). IgA class gliadin antibodies positivity was more pronounced in patients with Scheuer's stage III-IV disease (p < 0.05). Anti-transglutaminase antibodies were detected in 10% and in 18% of patients with primary biliary cirrhosis and autoimmune cholangitis respectively (p < 0.001). Anti-reticulin and anti-endomysial antibodies were negative in all patients. Duodenal biopsies were performed in 59% and 71% of patients with primary biliary cirrhosis and autoimmune cholangitis respectively, tested positive for at least one antibody class. No histological features of coeliac disease were found.
        
        
          Conclusions
          We were unable to demonstrate an increased risk of coeliac disease in patients with primary biliary cirrhosis and autoimmune cholangitis. Our results confirm the previously reported high prevalence of false-positive anti-gliadin and guinea pig liver-derived anti-tissue transglutaminase antibodies in patients with chronic liver disease.

Tags: anti-gliadin-antibodies, autoimmune-cholangitis, coeliac-disease, nih, primary-biliary-cirrhosis
Organization: U.S. Department of Health & Human Services
National Family Violence Survey, 1976

This study was conducted in 1976 at the University of New Hampshire.  2,134 respondents were interviewed in a nationwide sample of 960 males and 1,183 females.  The purpose of the study was to ascertain methods of conflict resolution within the family.  Information was gathered regarding the following areas:  resolution of conflicts between spouses and between parents and children, including detailed information on the development of conflicts resulting in violence, resolution of conflicts in respondent's childhood family, family power structure, marital closeness and stability, personality, and stress factors.

Investigators: Straus, M. A. & Gelles, R. J.

Tags: abuse, care, ndacan, policy, reporting
Organization: U.S. Department of Health & Human Services
2010 State Profile — Wisconsin

This state profile includes data from facilities in Wisconsin that reported to N-SSATS for the survey reference date March 31, 2010. Data were collected on the location, characteristics, services offered, and number of clients in treatment at alcohol and drug abuse treatment facilities (both public and private) in Wisconsin. In Wisconsin, 250 substance abuse treatment facilities were included in the 2010 N-SSATS, reporting that there were 17,385 clients in substance abuse treatment on March 31, 2010. The survey response rate in Wisconsin was 87.7%.

Tags: addiction-services, n-ssats, samhsa, substance-abuse-treatment, wisconsin
Organization: U.S. Department of Health & Human Services
Compound 528426: Tetrapropylene glycol monopropyl ether

Chemical compound data from PubChem database. IUPAC Name: 1-[1-[1-(1-propoxypropan-2-yloxy)propan-2-yloxy]propan-2-yloxy]propan-2-ol. Molecular Formula: C15H32O5. Molecular Weight: 292.41. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Table 1. Illicit Drug Use in the Past Month among Persons Aged 12 or Older, by State and Substate Regions: Percentages, Annual Averages Based on 2010, 2011, and 2012 NSDUHs

Table 1. Illicit Drug Use in the Past Month among Persons Aged 12 or Older, by State and Substate Regions: Percentages, Annual Averages Based on 2010, 2011, and 2012 NSDUHs

Tags: adolescent-drug-use, illicit-drug-use, nsduh, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Changes to the Delivery of Training and Technical Assistance Briefing

JooYeun Chang, the Children’s Bureau Associate Commissioner, presents the upcoming changes to the delivery of training and technical assistance available to support states, tribes, territories, and courts. More information can be found in a related article in the February issue of CBX
  
  

.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: data, grant, policy, real, time
Organization: U.S. Department of Health & Human Services
Emergency Department Visits among Children: Psychotherapeutic Drugs Involved in Adverse Reactions or Taken by Accident

This Drug Abuse Warning Network (DAWN) short report discusses emergency department visits by children who consumed psychothapeutic drugs. It looks at the reasons for the visits (adverse reactions and accidental ingestion) for ages 0-5 and 6-11.

Tags: adverse-drug-reaction, emergency-department, pediatric-poisoning, psychotherapeutic-drugs, samhsa
Organization: U.S. Department of Health & Human Services
2018 Uniform Reporting System (URS) Table for Republic of Marshall Islands

This is the 2018 Uniform Reporting System (URS) Output Tables for Republic of Marshall Islands. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, marshall-islands, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Table 24. 2011-2012 NSDUH Any Mental Illness in the Past Year, by Age Group and State

Table 24. Any Mental Illness in the Past Year, by Age Group and State: Percentages, Annual Averages Based on 2011 and 2012 NSDUHs. Results are provided by State and for four age groups: 18 to 25, 26 or older, 18 or older and all persons 18 or older.

Tags: adult-mental-health, mental-illness-prevalence, nsduh-data, samhsa, state-level-data
Organization: U.S. Department of Health & Human Services
Compound 527351: 16,20,24-Trimethyl-tetratriacontyl cyanide

Chemical compound data from PubChem database. IUPAC Name: 17,21,25-trimethylhexatriacontanenitrile. Molecular Formula: C39H77N. Molecular Weight: 560.0. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
N-SUMHSS 2023 Questionnaire

This is the questionnaire for the 2023 National Substance Use and Mental Health Services Survey (N-SUMHSS). The N-SUMHSS is a voluntary annual survey of all active substance use and mental health facilities in the United States, its jurisdictions, and the District of Columbia. This document shows the series of questions substance use and mental health treatment facilities were asked for the N-SUMHSS.The survey consists of two introductory questions and four separate modules. Skip patterns in the survey direct participants on relevant modules depending on whether the facility is a substance use treatment facility, a mental health treatment facility, or both.Additionally, facilities operated by the Department of Veteran’s Affairs (VA) were asked to complete additional questions regarding VA services offered.The questionnaire for N-SUMHSS and its supplement(s) is available as a PDF file.

Tags: facility-survey, mental-health-services, n-sumhss, samhsa, substance-use-treatment
Organization: U.S. Department of Health & Human Services
Cytosolic acidification as a signal mediating hyperosmotic stress responses in

Background
          Dictyostelium cells exhibit an unusual response to hyperosmolarity that is distinct from the response in other organisms investigated: instead of accumulating compatible osmolytes as it has been described for a wide range of organisms, Dictyostelium cells rearrange their cytoskeleton and thereby build up a rigid network which is believed to constitute the major osmoprotective mechanism in this organism. To gain more insight into the osmoregulation of this amoeba, we investigated physiological processes affected under hyperosmotic conditions in Dictyostelium.
        
        
          Results
          We determined pH changes in response to hyperosmotic stress using FACS or 31P-NMR. Hyperosmolarity was found to acidify the cytosol from pH 7.5 to 6.8 within 5 minutes, whereas the pH of the endo-lysosomal compartment remained constant. Fluid-phase endocytosis was identified as a possible target of cytosolic acidification, as the inhibition of endocytosis observed under hypertonic conditions can be fully attributed to cytosolic acidification. In addition, a deceleration of vesicle mobility and a decrease in the NTP pool was observed.
        
        
          Conclusion
          Together, these results indicate that hyperosmotic stress triggers pleiotropic effects, which are partially mediated by a pH signal and which all contribute to the downregulation of cellular activity. The comparison of our results with the effect of hyperosmolarity and intracellular acidification on receptor-mediated endocytosis in mammalian cells reveals striking similarities, suggesting the hypothesis of the same mechanism of inhibition by low internal pH.

Tags: cytosolic-acidification, dictyostelium-cells, hyperosmotic-stress, nih, osmoprotective-mechanism
Organization: U.S. Department of Health & Human Services
State Panel Discussion for Courts Data Exchange

In this presentation, the Children's Bureau's Division of State Systems (DSS) hosted a state panel discussion on building and maintaining a data exchange between courts and child welfare information systems. This discussion included a description and background of the state data exchanges in Utah, Alabama, District of Columbia, and Texas. The participants conversed about data security and use, maintenance and enhancements of the data exchanges, and lessons learned.

Note: Due to a weather event, the speakers for Alabama were unable to attend and therefore, DSS provided a speaker to present their materials.

The speakers for this panel were:
Utah:

Alabama:

District of Columbia:

Texas:

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: data, policy, reporting, sery, time
Organization: U.S. Department of Health & Human Services
Selective alteration of gene expression in response to natural and synthetic retinoids.

Background
          Retinoids are very potent inducers of cellular differentiation and apoptosis, and are efficient anti-tumoral agents. Synthetic retinoids are designed to restrict their toxicity and side effects, mostly by increasing their selectivity toward each isotype of retinoic acids receptors (RARα,β, γ and RXRα, β, γ). We however previously showed that retinoids displayed very different abilities to activate retinoid-inducible reporter genes, and that these differential properties were correlated to the ability of a given ligand to promote SRC-1 recruitment by DNA-bound RXR:RAR heterodimers. This suggested that gene-selective modulation could be achieved by structurally distinct retinoids.
        
        
          Results
          Using the differential display mRNA technique, we identified several genes on the basis of their differential induction by natural or synthetic retinoids in human cervix adenocarcinoma cells. Furthermore, this differential ability to regulate promoter activities was also observed in murine P19 cells for the RARβ2 and CRABPII gene, showing conclusively that retinoid structure has a dramatic impact on the regulation of endogenous genes.
        
        
          Conclusions
          Our findings therefore show that some degree of selective induction or repression of gene expression may be achieved when using appropriately designed ligands for retinoic acid receptors, extending the concept of selective modulators from estrogen and peroxisome proliferator activated receptors to the class of retinoid receptors.

Tags: cellular-differentiation, cervical-cancer, gene-expression, nih, retinoid-therapy
Organization: U.S. Department of Health & Human Services
A comparison of balloon injury models of endovascular lesions in rat arteries

Background
          Balloon injury (BI) of the rat carotid artery (CCA) is widely used to study intimal hyperplasia (IH) and decrease in lumen diameter (LD), but CCA's small diameter impedes the evaluation of endovascular therapies. Therefore, we validated BI in the aorta (AA) and iliac artery (CIA) to compare it with CCA.
        
        
          Methods
          Rats underwent BI or a sham procedure (control). Light microscopic evaluation was performed either directly or at 1, 2, 3, 4 and 16 weeks follow-up. The area of IH and the change in LD (LD at 16 weeks minus LD post BI) were compared.
        
        
          Results
          In the BI-groups the area of IH increased to 0.14 ± 0.08 mm2 (CCA), 0.14 ± 0.03 mm2 (CIA) and 0.12 ± 0.04 mm2 (AA) at 16 weeks (NS). The LD decreased with 0.49 ± 0.07 mm (CCA), compared to 0.22 ± 0.07 mm (CIA) and 0.07 ± 0.10 mm (AA) at 16 weeks (p < 0.05). The constrictive vascular remodelling (CVR = wall circumference loss combined with a decrease in LD) was -0.17 ± 0.05 mm in CIA but absent in CCA and AA. No IH, no decrease in LD and no CVR was seen in the control groups.
        
        
          Conclusions
          BI resulted in: (1.) a decrease in LD in CCA due to IH, (2.) a decrease in LD in CIA due to IH and CVR, (3.) no change in LD in AA, (4.) Comparable IH development in all arteries, (5.) CCA has no vasa vasorum compared to CIA and AA, (6.) The CIA model combines good access for 2 F endovascular catheters with a decrease in LD due to IH and CVR after BI.

Tags: balloon-angioplasty, intimal-hyperplasia, nih, rat-model, vascular-remodeling
Organization: U.S. Department of Health & Human Services
Training practitioners in preparing systematic reviews: a cross-sectional survey of participants in the Australasian Cochrane Centre training program

Background
          Although systematic reviews of health care interventions are an invaluable tool for health care providers and researchers, many potential authors never publish reviews. This study attempts to determine why some people with interest in performing systematic reviews do not subsequently publish a review; and what steps could possibly increase review completion.
        
        
          Methods
          Cross-sectional survey by email and facsimile of the 179 participants in Australasian Cochrane Centre training events between 1998 and 2000.
        
        
          Results
          Ninety-two participants responded to the survey (51 percent). Response rate of deliverable surveys was 82 percent (92/112). The remainder of the participants had invalid or no contact information on file. More than 75 percent of respondents felt that the current workshops met their needs for training. The most critical barriers to completion of a Cochrane review were: lack of time (80 percent), lack of financial support (36 percent), methodological problems (23 percent) and problems with group dynamics (10 percent).
        
        
          Conclusions
          Strategies to protect reviewer time and increase the efficiency of the review process may increase the numbers of trained reviewers completing a systematic review.

Tags: cochrane-reviews, evidence-based-practice, health-research, nih, systematic-reviews
Organization: U.S. Department of Health & Human Services
2016 Uniform Reporting System (URS) Table for Virgin Islands

This is the 2016 Uniform Reporting System (URS) Output Tables for Virgin Islands. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: mental-health-services, national-outcome-measures, samhsa, substance-abuse-treatment, virgin-islands-health
Organization: U.S. Department of Health & Human Services
2017 Uniform Reporting System (URS) Table for New Mexico

This is the 2017 Uniform Reporting System (URS) Output Tables for New Mexico. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: mental-health-services, new-mexico, noms-data, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
2010 CMHS Uniform Reporting System (URS) Output Tables for Illinois

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2010. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: illinois-mental-health, mental-health-services, noms-data, samhsa, substance-abuse-treatment
Organization: U.S. Department of Health & Human Services
Compound 525091: 1,3-Dichloroisopropyl hexanoate

Chemical compound data from PubChem database. IUPAC Name: 1,2-dichloropropan-2-yl hexanoate. Molecular Formula: C9H16Cl2O2. Molecular Weight: 227.12. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 525477: 4-Methyl-2-thianonane

Chemical compound data from PubChem database. IUPAC Name: 2-methyl-1-methylsulfanylheptane. Molecular Formula: C9H20S. Molecular Weight: 160.32. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2012 NSDUH Data Collection Final Report

This is the data collection final report to the 2012 National Survey on Drug Use and Health (NSDUH).  The report documents sampling operations, counting and listing operations, data collection staffing, preparation of survey materials, field staff training, data collection procedures, response rates, and quality control procedures.

Tags: data-collection, mental-health, samhsa, substance-use, survey-methodology
Organization: U.S. Department of Health & Human Services
3.1 Million Adults with Mental Illness Were Unemployed (2008 to 2012 NSDUH)

This spotlight presents any mental illness in the past year among adults aged 18 to 64 using 2008 to 2012 National Surveys on Drug Use and Health (NSDUHs) by whether they are unemployed.

Tags: adult-mental-health, mental-illness, nsduh-data, samhsa, unemployment
Organization: U.S. Department of Health & Human Services
2011 State Profile — Virginia

This is a National Survey of Substance Abuse Treatment Services (N-SSATS) data table showing state profile for Virginia in 2011. N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 States, the District of Columbia, and other U.S. jurisdictions.

Tags: n-ssats, samhsa, substance-abuse-treatment, treatment-facilities, virginia
Organization: U.S. Department of Health & Human Services
4.5 Facility size in terms of number of clients, by facility operation and primary focus of facility: March 31, 2011. Number and percent distribution

This a National Survey of Substance Abuse Treatment Services (N-SSATS) data table showing facility size in terms of number of clients, by facility operation and primary focus of facility in 2011.

Tags: client-volume, facility-size, n-ssats, samhsa, substance-abuse-treatment
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: United States, Volume 6

The Behavioral Health Barometer: United States, Volume 6: Indicators as measured through the 2019 National Survey on Drug Use and Health and the National Survey of Substance Abuse Treatment Services, is one of a series of national, regional, and state reports that provide a snapshot of substance use and mental health in the United States.

Tags: behavioral-health, mental-health, nsduh-data, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Compound 525457: 3-Propyl-2,4-dithiapentane

Chemical compound data from PubChem database. IUPAC Name: 1,1-bis(methylsulfanyl)butane. Molecular Formula: C6H14S2. Molecular Weight: 150.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2011 State Profile — North Carolina

This is a National Survey of Substance Abuse Treatment Services (N-SSATS) data table showing state profiles for  North Carolina in 2011. N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 States, the District of Columbia, and other U.S. jurisdictions.

Tags: alcohol-drug-abuse, north-carolina, samhsa, substance-abuse-treatment, treatment-facilities
Organization: U.S. Department of Health & Human Services
Compound 528369: Nornicotine, N-formyl

Chemical compound data from PubChem database. IUPAC Name: 2-pyridin-3-ylpyrrolidine-1-carbaldehyde. Molecular Formula: C10H12N2O. Molecular Weight: 176.21. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Results of the Ticlid or Plavix Post-Stents (TOPPS) trial: do they justify the switch from ticlopidine to clopidogrel after coronary stent placement?

In the Ticlid or Plavix Post-Stents (TOPPS) trial, 1016 patients undergoing successful coronary stent placement were randomized to receive aspirin and either ticlopidine or clopidogrel. In this trial, the dosages and regimens of ticlopidine and clopidogrel resembled more closely those used in most catheterization laboratories than did the two previous randomized trials comparing ticlopidine and clopidogrel. The results of the TOPPS trial support the current practice of substituting ticlopidine for clopidogrel in stent patients.

Tags: antiplatelet-therapy, clopidogrel-vs-ticlopidine, coronary-stent, nih, topps-trial
Organization: U.S. Department of Health & Human Services