AndreaBozzo/ceres-open-data-index huggingface dataset:
Compound 527938: 15-Chlorooctadecyl acetate

Chemical compound data from PubChem database. IUPAC Name: 15-chlorooctadecyl acetate. Molecular Formula: C20H39ClO2. Molecular Weight: 347.0. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Forty-Two Percent of Substance Abuse Treatment Facilities Offer On-Site Screening for Infectious Diseases

This report is a National Survey of Substance Abuse Treatment Services (N-SSATS) spotlight about substance abuse treatment facilities that offered on-site screening for infectious diseases in 2011.

Tags: co-occurring-disorders, infectious-disease-screening, n-ssats, samhsa, substance-abuse-treatment
Organization: U.S. Department of Health & Human Services
Patent AT-E401642-T1: [Translated] METHOD FOR LINEING UP PLANES DURING LANDING APPROACH

Many types of vehicle disturb the environment behind them as they proceed. As a result, a delay between two successive vehicles has to be maintained to avoid a situation where following vehicles are adversely affected by the disturbed environment caused by leading vehicles. Previously, sequencing has been carried out on a "first come, first served" basis but this is not satisfactory. A method of sequencing a plurality of vehicles is disclosed, wherein each candidate vehicle in said plurality of candidate vehicles is a candidate to be allocated the next place in a sequence, said method comprising the steps of: (i) receiving information pertaining to one of said candidate vehicles; (ii) calculating a value to be attributed to said candidate vehicle on the basis of said received information and information received from the candidate vehicle most recently allocated a place in said sequence; (iii) repeating steps (i) and (ii) for each of said candidate vehicles; (iv) selecting one of said candidate vehicles based on said attributed values; and (v) allocating said selected candidate vehicle the next place in said sequence.

Tags: chemistry, innovation, patent, pubchem, research
Organization: U.S. Department of Health & Human Services
Tribal and Native American Organization Funding

ACF’s programs help address COVID-19 recovery and support the needs of children, youth, and families. This page provides information on new funding announcements, ACF programs that are available to Tribes and Native communities, ACF tribal and Native organization funding recipients, and other useful funding-related information. ACF’s programs awarded $1.76 billion in supplemental COVID-19 funding to tribes and Native communities. These funds are in addition to the more than $1 billion the agency awards to tribes and Native communities each year.

Open ACF Notice of Funding Opportunity (NOFO) Announcements

You can explore a list of ACF Program Office’s NOFOs here that are currently open and accepting applications.

Forecast synopses and all full competitive ACF NOFOs are posted at Grants.gov
  
  

  — the same place you will go to submit your application

Helpful Tip: Keeping Up-to-Date

Register on Grants.gov
  
  

  to create an account and receive email notifications when there are changes to your chosen funding opportunities.

COVID-19 Supplemental Funds FY2020 (XLSX)

COVID-19 Supplemental Funds FY2021 (XLSX)

GY 2022 CCDF Tribal Allocations (Based on Appropriations)

GY 2021 CCDF Final Tribal Allocations

FY 2022 ACF Tribal and Native Organizations Funding Report (XLSX)

Explore the Tribes and Native organizations that received ACF Program Office funding in FY 2022 in this report.

FY 2021 ACF Tribal and Native Organizations Funding Report (XLSX)

Explore the Tribes and Native organizations that received ACF Program Office funding in FY 2021 in this report.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: 19, fiscal, mental, policy, response
Organization: U.S. Department of Health & Human Services
Compound 526976: (10,13-Dimethyl-3-oxo-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl) decanoate

Chemical compound data from PubChem database. IUPAC Name: (10,13-dimethyl-3-oxo-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl) decanoate. Molecular Formula: C29H48O3. Molecular Weight: 444.7. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Cell-cell interactions in synovitis: Interactions between T cells and B cells in rheumatoid arthritis

In rheumatoid arthritis, T cells and B cells participate in the immune responses evolving in the synovial lesions. Interaction between T cells and B cells is probably antigen specific because complex microstructures typical of secondary lymphoid organs are generated. Differences between patients in forming follicles with germinal centers, T-cell–B-cell aggregates without germinal center reactions, or loosely organized T-cell–B-cell infiltrates might reflect the presence of different antigens or a heterogeneity in host response patterns to immune injury. Tertiary lymphoid microstructures in the rheumatoid lesions can enhance the sensitivity of antigen recognition, optimize the collaboration of immunoregulatory and effector cells, and support the interaction between the tissue site and the aberrant immune response. The molecular basis of lymphoid organogenesis studied in gene-targeted mice will provide clues to why the synovium is a preferred site for tertiary lymphoid tissue. B cells have a critical role in lymphoid organogenesis. Their contribution to synovial inflammation extends beyond antibody secretion and includes the activation and regulation of effector T cells.

Tags: b-cells, nih, rheumatoid-arthritis, synovitis, t-cells
Organization: U.S. Department of Health & Human Services
Extracorporeal membrane oxygenation for severe acute respiratory failure

Extracorporeal membrane oxygenation (ECMO) is a technique for providing life support, in case the natural lungs are failing and are not able to maintain a sufficient oxygenation of the body's organ systems. ECMO technique was an adaptation of conventional cardiopulmonary bypass technique and introduced into treatment of severe acute respiratory distress syndrome (ARDS) in the 1970s. The intial reports of the use of ECMO in ARDS patients were quite enthusiastic, however, in the following years it became clear that ECMO was only of benefit in newborns with acute respiratory failure. In neonates treated with ECMO, survival rates of 80% could be achieved. In adult patients with ARDS, two large randomized controlled trials (RCTs) published in 1979 and 1994 failed to show an advantage of ECMO over convential treatment, survival rates were only 10% and 33%, respectively, in the ECMO groups. Since then, ECMO technology as well as conventional treatment of adult ARDS have undergone further improvements.  In conventional treatment lung-protective ventilation strategies were introduced and ECMO was made safer by applying heparin-coated equipment, membranes and tubings. Many ECMO centres now use these advanced ECMO technology and report survival rates in excess of  50% in uncontrolled data collections. The question, however, of whether the improved ECMO can really challenge the advanced conventional treatment of adult ARDS is unanswered and will need evaluation by a future RCT.

Tags: ards-treatment, ecmo-therapy, nih, oxygenation-therapy, respiratory-failure
Organization: U.S. Department of Health & Human Services
2021 National Substance Use And Mental Health Services Survey (N-SUMHSS) State Profiles

The state profiles present findings from the annual National Substance Use and Mental Health Services Survey (N-SUMHSS). Each state profile provides summary information on substance use and mental health treatment facilities’ characteristics, services offered, client numbers and a mapping of treatment facility locations within the state.

Tags: mental-health-services, n-sumhss, samhsa, substance-use-treatment, treatment-facility-data
Organization: U.S. Department of Health & Human Services
Compound 525198: Chloromethyl 2-chloropentanoate

Chemical compound data from PubChem database. IUPAC Name: chloromethyl 2-chloropentanoate. Molecular Formula: C6H10Cl2O2. Molecular Weight: 185.05. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Volumetric computerized tomography as a measurement of periprosthetic acetabular osteolysis and its correlation with wear

Osteolysis, which is considered to be a major source of morbidity following total hip joint replacement, has been notoriously difficult to measure accurately, particularly in the acetabular area. In order to study periacetabular osteolysis, specialized software for computerized tomography (CT) scan image analysis has been developed. This software (3D-CT) eliminates metal artifacts, allows three-dimensional segmentation of the CT image, and reconstructs the segmented image to provide an accurate representation and measurement of volume for osteolytic lesions. In the present study, 20 patients underwent periacetabular osteolytic volume determination using 3D-CT, functional assessment (using the Harris Hip Scale, the Western Ontario and McMaster University Osteoarthritis Index, and the short form 36 questionnaire), and two-dimensional analysis of volumetic polyethylene wear using digitalized plain films. Periacetabular osteolysis correlated directly with the polyethylene wear rate (relative risk [RR] = 0.494, P = 0.027). If one patient with an acetabular revision, one patient with recurrent dislocation, and one patient with a Biomet prosthesis are excluded, then the correlation between wear and osteolysis is improved (RR = 0.685, P = 0.002). In summary, the current study demonstrates both the feasibility of CT imaging of periacetabular osteolysis and the correlation between polyethylene wear and osteolytic volume, providing a potential outcome measure for clinical trials that are designed to examine interventions in this complex disease process.

Tags: ct-imaging, nih, periprosthetic-osteolysis, polyethylene-wear, total-hip-arthroplasty
Organization: U.S. Department of Health & Human Services
Compound 527791: Prop-2-ynyl 3-chlorobenzoate

Chemical compound data from PubChem database. IUPAC Name: prop-2-ynyl 3-chlorobenzoate. Molecular Formula: C10H7ClO2. Molecular Weight: 194.61. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 528125: 2-Methyl-5-(2-methylbutyl)-3-octylpyrazine

Chemical compound data from PubChem database. IUPAC Name: 2-methyl-5-(2-methylbutyl)-3-octylpyrazine. Molecular Formula: C18H32N2. Molecular Weight: 276.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Characterization of DNA binding, transcriptional activation, and regulated nuclear association of recombinant human NFATp

Background
          NFATp is one member of a family of transcriptional activators whose nuclear accumulation and hence transcriptional activity is regulated in mammalian cells. Human NFATp exists as a phosphoprotein in the cytoplasm of naive T cells. Upon antigen stimulation, NFATp is dephosphorylated, accumulates in nuclei, and functions to regulate transcription of genes including those encoding cytokines. While the properties of the DNA binding domain of NFATp have been investigated in detail, biochemical studies of the transcriptional activation and regulated association with nuclei have remained unexplored because of a lack of full length, purified recombinant NFATp.
        
        
          Results
          We developed methods for expressing and purifying full length recombinant human NFATp that has all of the properties known to be associated with native NFATp. The recombinant NFATp binds DNA on its own and cooperatively with AP-1 proteins, activates transcription in vitro, is phosphorylated, can be dephosphorylated by calcineurin, and exhibits regulated association with nuclei in vitro. Importantly, activation by recombinant NFATp in a reconstituted transcription system required regions of the protein outside of the central DNA binding domain.
        
        
          Conclusions
          We conclude that NFATp is a bona fide transcriptional activator. Moreover, the reagents and methods that we developed will facilitate future studies on the mechanisms of transcriptional activation and nuclear accumulation by NFATp, a member of an important family of transcriptional regulatory proteins.

Tags: cytokine-regulation, dna-binding, nfatp-transcription, nih, t-cell-activation
Organization: U.S. Department of Health & Human Services
Future of adenoviruses in the gene therapy of arthritis

Recombinant adenoviruses are straightforward to produce at high titres, have a promiscuous host-range, and, because of their ability to infect nondividing cells, lend themselves to in vivo gene delivery. Such advantages have led to their widespread and successful use in preclinical studies of arthritis gene therapy. While adenoviral vectors are well suited to 'proof of principle' experiments in laboratory animals, there are several barriers to their use in human studies at this time. Transient transgene expression limits their application to strategies, such as synovial ablation, which do not require extended periods of gene expression. Moreover, there are strong immunological barriers to repeat dosing. In addition, safety concerns predicate local, rather than systemic, delivery of the virus. Continued engineering of the adenoviral genome is producing vectors with improved properties, which may eventually overcome these issues. Promising avenues include the development of 'gutted' vectors encoding no endogenous viral genes and of adenovirus–AAV chimeras. Whether these will offer advantages over existing vectors, which may already provide safe, long-term gene expression following in vivo delivery, remains to be seen.

Tags: adenovirus-vectors, arthritis-gene-therapy, gene-delivery, nih, synovial-ablation
Organization: U.S. Department of Health & Human Services
Compound 525624: N,N-Dimethyl-N'-decyl-p-methoxybenzamidine

Chemical compound data from PubChem database. IUPAC Name: N'-decyl-4-methoxy-N,N-dimethylbenzenecarboximidamide. Molecular Formula: C20H34N2O. Molecular Weight: 318.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Patent AT-E399753-T1: [Translated] AMIDES AS PYRUVATE DEHYDROGENASE INHIBITORS

A compound of formula (I):wherein:Ring A is a nitrogen linked mono or bicyclic heterocyclic ring as defined within;R<1 >and R<2 >are independently C1-3alkyl optionally substituted by fluoro or chloro;or R<1 >and R<2 >together with the carbon atom to which they are attached, form a C3-5cycloalkyl ring optionally substituted by fluoro;R<3 >is defined within; andn is 0-5; wherein the values of R<3 >may be the same or different;or a pharmaceutically acceptable salt or an in vivo hydrolysable ester thereof is described. The use of compounds of formula (I) in the production of an elevation of PDH activity in a warm-blooded animal such as a human being are also described. Pharmaceutical compositions, methods and processes for preparation of compounds of formula (I) are detailed.

Tags: chemistry, innovation, patent, pubchem, research
Organization: U.S. Department of Health & Human Services
Compound 528135: 5-Isobutyl-3-methyl-2-methoxypyrazine

Chemical compound data from PubChem database. IUPAC Name: 2-methoxy-3-methyl-5-(2-methylpropyl)pyrazine. Molecular Formula: C10H16N2O. Molecular Weight: 180.25. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 525393: 2,6-Dimethyl-4-ethyl-3,5-dithiaheptane

Chemical compound data from PubChem database. IUPAC Name: 1,1-bis(propan-2-ylsulfanyl)propane. Molecular Formula: C9H20S2. Molecular Weight: 192.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 529445: Indane, 1-(2-phenylethyl)

Chemical compound data from PubChem database. IUPAC Name: 1-(2-phenylethyl)-2,3-dihydro-1H-indene. Molecular Formula: C17H18. Molecular Weight: 222.32. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 527847: 2,4-Dichlorobenzyl nonyl ether

Chemical compound data from PubChem database. IUPAC Name: 2,4-dichloro-1-(nonoxymethyl)benzene. Molecular Formula: C16H24Cl2O. Molecular Weight: 303.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2019 Uniform Reporting System (URS) Table for Virginia

These are the 2019 Uniform Reporting System (URS) Output Tables for Virginia. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, evidence-based-practices, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Patent AT-E401501-T1: [Translated] WIND TURBINE WITH HYDRAULIC TRANSMISSION

Chemical patent from PubChem database. Patent Number: AT-E401501-T1. Title: Chemical Synthesis Method. Filing Date: 1996-05-06. Inventors: Yamamoto, Hiroshi, Schmidt, Hans. Abstract: A novel method for chemical synthesis is provided, utilizing specific catalysts and reaction conditions to achieve selective transformations with high... IPC Classifications: C07H, A61K, A61P. This patent covers 17 claims related to 7 chemical compounds. Useful for intellectual property research, prior art searches, and chemical innovation tracking.

Tags: chemistry, innovation, patent, pubchem, research
Organization: U.S. Department of Health & Human Services
2011-2012 NSDUH State Prevalence Estimates – Individual Excel Tables by Outcome

These are 2011-2012 NSDUH State estimates. Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Results are provided by State and for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: mental-illness, samhsa, state-prevalence, substance-use, suicidal-ideation
Organization: U.S. Department of Health & Human Services
Patent AT-E400383-T1: [Translated] HEATING TO CONTROL THE SOLIDIFICATION OF A CAST STRUCTURE

A method for the production of a cast component comprising the steps of:1) providing a molten metal mass in a casting mold and exposing the casting mold to a cooling environment thereby creating a solidification interface between molten metal regions and solidified metal regions, and2) applying at least one focused energy source either to a portion of the filled casting mold to control a temperature gradient near the solidification interface.

Tags: chemistry, innovation, patent, pubchem, research
Organization: U.S. Department of Health & Human Services
Compound 526941: 2-Methyl-3-thienyl 2-thienyl disulphide

Chemical compound data from PubChem database. IUPAC Name: 2-methyl-3-(thiophen-2-yldisulfanyl)thiophene. Molecular Formula: C9H8S4. Molecular Weight: 244.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 526609: 3-O-Acetyl-2,6-anhydro-1,4,5-tri-O-methylhexitol

Chemical compound data from PubChem database. IUPAC Name: [4,5-dimethoxy-2-(methoxymethyl)oxan-3-yl] acetate. Molecular Formula: C11H20O6. Molecular Weight: 248.27. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services