AndreaBozzo/ceres-open-data-index huggingface dataset:
Lack of association between estrogen receptor β dinucleotide repeat polymorphism and autoimmune thyroid diseases in Japanese patients

Background
          The autoimmune thyroid diseases (AITDs), such as Graves' disease (GD) and Hashimoto's thyroiditis (HT), appear to develop as a result of complex interactions between predisposing genes and environmental triggers. Susceptibility to AITDs is conferred by genes in the human leukocyte antigen (HLA) and genes unlinked to HLA, including the CTLA-4 gene. Recently, estrogen receptor (ER) β, located at human chromosome 14q23-24.1, was identifed. We analyzed a dinucleotide (CA)n repeat polymorphism located in the flanking region of ERβ gene in patients with AITDs and in normal subjects. High heterozygosity makes this polymorphism a useful marker in the genetic study of disorders affecting female endocrine systems. We also correlated a ERβ gene microsatellite polymorphism with bone mineral density (BMD) in the distal radius and biochemical markers of bone turnover in patients with GD in remission.
        
        
          Results
          Fourteen different alleles were found in 133 patients with GD, 114 patients with HT, and 179 controls subjects. The various alleles were designated as allele*1 through allele*14 according to the number of the repeats, from 18 to 30. There was no significant difference in the distributions of ERβ alleles between patient groups and controls. Although recent study demonstrated a significant relation between a allele*9 in the ERβ gene and BMD in postmenopausal Japanese women, there were no statistically significant interaction between this allele and BMD in the distal radius, nor biochemical markers in patients with GD in remission.
        
        
          Conclusions
          The present results do not support an association between the ERβ microsatellite marker and AITD in the Japanese population. We also suggest that the ERβ microsatellite polymorphism has at most a minor pathogenic importance in predicting the risk of osteoporosis as a complication of GD.

Tags: autoimmune-thyroid-disease, estrogen-receptor-beta, graves-disease, hashimotos-thyroiditis, nih
Organization: U.S. Department of Health & Human Services
2012 Uniform Reporting System (URS) Tables for Oklahoma

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2012. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, national-outcome-measures, oklahoma, samhsa
Organization: U.S. Department of Health & Human Services
2012 Uniform Reporting System (URS) Tables for Pennsylvania

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2012. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, outcome-measures, samhsa, urs-data
Organization: U.S. Department of Health & Human Services
Compound 527273: Pentanoic acid, 4-methyl, 2,2,2-trichloroethyl ester

Chemical compound data from PubChem database. IUPAC Name: 2,2,2-trichloroethyl 4-methylpentanoate. Molecular Formula: C8H13Cl3O2. Molecular Weight: 247.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Therapy of ankylosing spondylitis and other spondyloarthritides: established medical treatment, anti-TNF-α therapy and other novel approaches

Therapeutic options for patients with more severe forms of spondyloarthritis (SpA) have been rather limited in recent decades. There is accumulating evidence that anti-tumor-necrosis-factor (anti-TNF) therapy is highly effective in SpA, especially in ankylosing spondylitis and psoriatic arthritis. The major anti-TNF-α agents currently available, infliximab (Remicade®) and etanercept (Enbrel®), are approved for the treatment of rheumatoid arthritis (RA) in many countries. In ankylosing spondylitis there is an unmet medical need, since there are almost no disease-modifying antirheumatic drugs (DMARDs) available for severely affected patients, especially those with spinal manifestations. Judging from recent data from more than 300 patients with SpA, anti-TNF therapy seems to be even more effective in SpA than in rheumatoid arthritis. However, it remains to be shown whether patients benefit from long-term treatment, whether radiological progression and ankylosis can be stopped and whether long-term biologic therapy is safe.

Tags: ankylosing-spondylitis, anti-tnf-therapy, nih, psoriatic-arthritis, spondyloarthritis
Organization: U.S. Department of Health & Human Services
Substance Use and Mental Health Issues among U.S.-Born American Indians or Alaska Natives Residing on and off Tribal Lands

This report provides methodological information on how to obtain estimates of behavioral health outcomes for populations living on and off tribal lands and provides some initial estimates using NSDUH 2005 to 2014 data.

Tags: american-indian-alaska-native, behavioral-health-outcomes, samhsa, substance-use-mental-health, tribal-lands
Organization: U.S. Department of Health & Human Services
2019 Uniform Reporting System (URS) Table for Ohio

These are the 2019 Uniform Reporting System (URS) Output Tables for Ohio. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: mental-health-services, national-outcome-measures, ohio, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
Minneapolis: Drug-Related Emergency Department Visits, 2004-2011 - All Alcohol

Excel file with estimates, rates, relative standard errors, trends and confidence intervals, covering 2004-2011 for emergency department visits involving alcohol in the Miami metropolitan area.  For adults aged 21 and older, the alcohol was found in combination with other drugs. For patients under the age of 21, the visit may involve alcohol alone or in combination with other drugs.File includes data for over 500 drugs, including illicit drugs, prescription and over-the-counter medications, dietary supplements, inhalants and alcohol.  Includes total visits, gender, age group, race/ethnicity, outcome of visit, drug combinations, number of drugs involved in visit, drug frequency, and drugs confirmed by toxicology.Additional detail is provided for illicit drugs, psychotherapeutic drugs, central nervous system (CNS) drugs, respiratory drugs and cardiovascular drugs.

Tags: alcohol-drug-combinations, alcohol-related-ed-visits, emergency-department-alcohol, minneapolis-alcohol-data, samhsa
Organization: U.S. Department of Health & Human Services
Detection of fast light-activated H

Background
          Proteorhodopsin (pR) is a light-activated proton pump homologous to bacteriorhodopsin and recently discovered in oceanic γ-proteobacteria. One perplexing difference between these two proteins is the absence in pR of homologues of bR residues Glu-194 and Glu-204. These two residues, along with Arg-82, have been implicated in light-activated fast H+ release to the extracellular medium in bR. It is therefore uncertain that pR carries out its physiological activity using a mechanism that is completely homologous to that of bR.
        
        
          Results
          A pR purification procedure is described that utilizes Phenylsepharose™ and hydroxylapatite columns and yields 85% (w/w) purity. Through SDS-PAGE of the pure protein, the molecular weight of E.-coli-produced pR was determined to be 36,000, approximately 9,000 more than the 27,000 predicted by the DNA sequence. Post-translational modification of one or more of the cysteine residues accounts for 5 kDa of the weight difference as measured on a cys-less pR mutant. At pH 9.5 and in the presence of octylglucoside and diheptanoylphosphotidylcholine, flash photolysis results in fast H+ release and a 400-nm absorbing (M-like) photoproduct. Both of these occur with a similar rise time (4–10 μs) as reported for monomeric bR in detergent.
        
        
          Conclusions
          The presence of fast H+ release in pR indicates that either different groups are responsible for fast H+ release in pR and bR (i.e. that the H+ release group is not highly conserved); or, that the H+ release group is conserved and is therefore likely Arg-94 itself in pR (and Arg-82 in bR, correspondingly).

Tags: bacteriorhodopsin, light-activation, nih, proteorhodopsin, proton-pump
Organization: U.S. Department of Health & Human Services
Title IV-E Programs Expenditure and Caseload Data 2021

The Children’s Bureau posts an annual FY summary of Form CB-496 expenditures and caseloads as reported by each title IV-E agency. These data tables include the combination of current-quarter and prior-quarter adjustment expenditures and current-quarter caseload data as delineated in quarterly Form CB-496 submissions for FY 2021.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: child, policy, real, reporting, time
Organization: U.S. Department of Health & Human Services
The linkage between β1 integrin and the actin cytoskeleton is differentially regulated by tyrosine and serine/threonine phosphorylation of β1 integrin in normal and cancerous human breast cells

Background
          Structural requirements for the β1 integrin functions in cell adhesion, spreading and signaling have been well documented mainly for fibroblasts. In this study, we examined the reason for the reduced surface expression of β1 integrin in human breast cancer MCF-7 cells compared to normal human breast epithelial (HBE) cells, both of which adhered to collagen type IV.
        
        
          Results
          The β1 integrin immunoprecipitates from either HBE or MCF-7 cells involved α-actinin while actin coprecipitated with β1 integrin from HBE cells but not from MCF-7 cells. Immunoblotting using the anti-phosphotyrosine (PY) antibody indicated the phosphorylation of β1 integrin at least at tyrosine in both cells. Dephosphorylation of β1 integrin from HBE cells by protein tyrosine phosphatase (PTP), but not by protein serine/threonine phosphatase (PP), caused dissociation of actin from β1 integrin, although dephosphorylation of it from MCF-7 cells by either PTP or PP caused association of the two proteins. In MCF-7 cells β1 integrin coprecipitated doublet of proteins having the Ca2+/calmodulin-dependent protein kinase (CaMK) II activity that was susceptible to KN-62, a specific inhibitor of CaMKII.
        
        
          Conclusion
          The results suggest that β1 integrin is tyrosine phosphorylated and links with actin via α-actinin in HBE cells but prevented from linking with actin in MCF-7 cells by phosphorylation at both tyrosine and serine/threonine of β1 integrin which forms a complex with α-actinin and CaMKII. Thus the linkage formation of β1 integrin with actin may be differentially regulated by its tyrosine and serine/threonine phosphorylation in normal HBE cells and breast cancer MCF-7 cells.

Tags: actin-cytoskeleton, breast-cancer-cells, cell-adhesion, integrin-phosphorylation, nih
Organization: U.S. Department of Health & Human Services
Compound 525163: Heptapropylene glycol, diacetate

Chemical compound data from PubChem database. IUPAC Name: 2-[2-[2-[2-[2-[2-(2-acetyloxypropoxy)propoxy]propoxy]propoxy]propoxy]propoxy]propyl acetate. Molecular Formula: C25H48O10. Molecular Weight: 508.6. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Protein microarrays for highly parallel detection and quantitation of specific proteins and antibodies in complex solutions

Background:
          We have developed and tested a method for printing protein microarrays and using these microarrays in a comparative fluorescence assay to measure the abundance of many specific proteins in complex solutions. A robotic device was used to print hundreds of specific antibody or antigen solutions in an array on the surface of derivatized microscope slides. Two complex protein samples, one serving as a standard for comparative quantitation, the other representing an experimental sample in which the protein quantities were to be measured, were labeled by covalent attachment of spectrally resolvable fluorescent dyes.
        
        
          Results:
          Specific antibody-antigen interactions localized specific components of the complex mixtures to defined cognate spots in the array, where the relative intensity of the fluorescent signal representing the experimental sample and the reference standard provided a measure of each protein's abundance in the experimental sample. To test the specificity, sensitivity and accuracy of this assay, we analyzed the performance of 115 antibody/antigen pairs. 50% of the arrayed antigens and 20% of the arrayed antibodies provided specific and accurate measurements of their cognate ligands at or below concentrations of 0.34 μg/ml and 1.6 μg/ml, respectively. Some of the antibody/antigen pairs allowed detection of the cognate ligands at absolute concentrations below 1 ng/ml, and partial concentrations of 1 part in 106, sensitivities sufficient for measurement of many clinically important proteins in patient blood samples.
        
        
          Conclusions:
          These results suggest that protein microarrays can provide a practical means to characterize patterns of variation in hundreds of thousands of different proteins in clinical or research applications.

Tags: antibody-detection, fluorescence-assay, nih, protein-microarrays, protein-quantitation
Organization: U.S. Department of Health & Human Services
Comparison Between 2019-2020 NSDUH State Prevalence Estimates

State estimates for these years are no longer available due to methodological concerns with combining 2019 and 2020 data. We apologize for any inconvenience or confusion this may causeBecause of the COVID-19 pandemic, most respondents answered the survey via the web in Quarter 4 of 2020, even though all responses in Quarter 1 were from in-person interviews. It is known that people may respond to the survey differently while taking it online, thus introducing what is called a mode effect.When the state estimates were released, it was assumed that the mode effect was similar for different groups of people. However, later analyses have shown that this assumption should not be made. Because of these analyses, along with concerns about the rapid societal changes in 2020, it was determined that averages across the two years could be misleading.For more detail on this decision, see the 2019-2020state data page.

Tags: mental-health, samhsa, state-prevalence, substance-use, survey-data
Organization: U.S. Department of Health & Human Services
2018 Uniform Reporting System (URS) Table for Idaho

This is the 2018 Uniform Reporting System (URS) Output Tables for Idaho. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-program, community-mental-health, mental-health-services, outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
2021 Uniform Reporting System (URS) Table For West Virginia

This is the 2021 Uniform Reporting System (URS) Output Tables for West Virginia. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-data, mental-health-services, national-outcome-measures, samhsa, west-virginia
Organization: U.S. Department of Health & Human Services
Detroit: Drug-Related Emergency Department Visits, 2004-2011 - Underage Drinking

Excel file with estimates, rates, relative standard errors, trends and confidence intervals for all drug-related emergency department (ED) visits involving underage drinking in the Detroit metropolitan area, covering 2004-2011.  Underage drinking includes ED visits that involve alcohol use (alone or with other drugs) for patients under the age of 21.

Tags: alcohol-related-visits, detroit-metro-area, emergency-department, samhsa, underage-drinking
Organization: U.S. Department of Health & Human Services
2014 CMHS Uniform Reporting System (URS) Table for Mississippi

2014 Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for Mississippi. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: mental-health-services, mississippi, noms-measures, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
2018 Uniform Reporting System (URS) Table for Puerto Rico

This is the 2018 Uniform Reporting System (URS) Output Tables for Puerto Rico. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant, mental-health-services, outcome-measures, puerto-rico, samhsa
Organization: U.S. Department of Health & Human Services
4.20 Facilities with Opioid Treatment Programs (OTPs) and clients receiving medication-assisted opioid therapy at OTPs and other facilities, by facility operation and primary focus of facility: March 31, 2011.  Number and percent distribution

This is a National Survey of Substance Abuse Treatment Services (N-SSATS) data table showing facilities with Opioid Treatment Programs (OTPs) and clients receiving medication-assisted opioid therapy at OTPs and other facilities, by facility operation and primary focus of facility in March 3, 2011. N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 States, the District of Columbia, and other U.S. jurisdictions.

Tags: medication-assisted-therapy, opioid-treatment-programs, samhsa, substance-abuse-treatment, survey
Organization: U.S. Department of Health & Human Services
Compound 525468: Ethyl allyl disulfide

Chemical compound data from PubChem database. IUPAC Name: 3-(ethyldisulfanyl)prop-1-ene. Molecular Formula: C5H10S2. Molecular Weight: 134.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Are plant formins integral membrane proteins?

Background:
          The formin family of proteins has been implicated in signaling pathways of cellular morphogenesis in both animals and fungi; in the latter case, at least, they participate in communication between the actin cytoskeleton and the cell surface. Nevertheless, they appear to be cytoplasmic or nuclear proteins, and it is not clear whether they communicate with the plasma membrane, and if so, how. Because nothing is known about formin function in plants, I performed a systematic search for putative Arabidopsis thaliana formin homologs.
        
        
          Results:
          I found eight putative formin-coding genes in the publicly available part of the Arabidopsis genome sequence and analyzed their predicted protein sequences. Surprisingly, some of them lack parts of the conserved formin-homology 2 (FH2) domain and the majority of them seem to have signal sequences and putative transmembrane segments that are not found in yeast or animals formins.
        
        
          Conclusions:
          Plant formins define a distinct subfamily. The presence in most Arabidopsis formins of sequence motifs typical or transmembrane proteins suggests a mechanism of membrane attachment that may be specific to plant formins, and indicates an unexpected evolutionary flexibility of the conserved formin domain.

Tags: arabidopsis-thaliana, formin-proteins, integral-membrane-proteins, nih, plant-formins
Organization: U.S. Department of Health & Human Services
Maltreatment and the Academic and Social Adjustment of School Children, 1987-1988

This study examined the effects of child abuse and neglect on academic achievement and social adjustment in the school setting.  The data were derived from a population of 8600 children attending public schools (grades K to 12) in a small city in New York State between 1987 and 1988.  From this population of children, 1239 were found to have been substantiated victims of abuse or neglect on at least one occasion.  A stratified sampling procedure was employed to select a sample of maltreated children.  The final sample selected for the study consists of 420 maltreated children and 420 matched controls from regular classrooms (i.e., not from special education classrooms). Children selected for the control group were matched by school, gender, grade in school, residential location, and when possible by classroom.  The machine-readable data file contains 840 observations and 430 variables that describe maltreatment history, school behavioral problems, educational services received, and academic achievement. These variables were derived from social service and school records.

Investigators: Eckenrode, John & Doris, John

Tags: abuse, care, ndacan, policy, reporting
Organization: U.S. Department of Health & Human Services
2016 Uniform Reporting System (URS) Output Tables

These are the 2016 Uniform Reporting System (URS) Output Tables. URS is a state, national, and territories reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-program, evidence-based-practices, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Compound 525044: 3',4'-Dichloropelargoanilide

Chemical compound data from PubChem database. IUPAC Name: N-(3,4-dichlorophenyl)nonanamide. Molecular Formula: C15H21Cl2NO. Molecular Weight: 302.2. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services