AndreaBozzo/ceres-open-data-index huggingface dataset:
Gene discovery within the planctomycete division of the domain Bacteria using sequence tags from genomic DNA libraries

Background
          The planctomycetes comprise a distinct group of the domain Bacteria, forming a separate division by phylogenetic analysis. The organization of their cells into membrane-defined compartments including membrane-bounded nucleoids, their budding reproduction and complete absence of peptidoglycan distinguish them from most other Bacteria. A random sequencing approach was applied to the genomes of two planctomycete species, Gemmata obscuriglobus and Pirellula marina, to discover genes relevant to their cell biology and physiology.
        
        
          Results
          Genes with a wide variety of functions were identified in G. obscuriglobus and Pi. marina, including those of metabolism and biosynthesis, transport, regulation, translation and DNA replication, consistent with established phenotypic characters for these species. The genes sequenced were predominantly homologous to those in members of other divisions of the Bacteria, but there were also matches with nuclear genomic genes of the domain Eukarya, genes that may have appeared in the planctomycetes via horizontal gene transfer events. Significant among these matches are those with two genes atypical for Bacteria and with significant cell-biology implications - integrin alpha-V and inter-alpha-trypsin inhibitor protein - with homologs in G. obscuriglobus and Pi. marina respectively.
        
        
          Conclusions
          The random-sequence-tag approach applied here to G. obscuriglobus and Pi. marina is the first report of gene recovery and analysis from members of the planctomycetes using genome-based methods. Gene homologs identified were predominantly similar to genes of Bacteria, but some significant best matches to genes from Eukarya suggest that lateral gene transfer events between domains may have involved this division at some time during its evolution.

Tags: bacteria-genomes, gene-discovery, genomic-dna, nih, planctomycetes
Organization: U.S. Department of Health & Human Services
Compound 530512: 2-Chlorobenzoic acid, 2-(1-adamantyl)ethyl ester

Chemical compound data from PubChem database. IUPAC Name: 2-(1-adamantyl)ethyl 2-chlorobenzoate. Molecular Formula: C19H23ClO2. Molecular Weight: 318.8. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 530312: Methyl 2-hydroxyheptadecanoate

Chemical compound data from PubChem database. IUPAC Name: methyl 2-hydroxyheptadecanoate. Molecular Formula: C18H36O3. Molecular Weight: 300.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Miami - Fort Lauderdale Div: Drug-Related Emergency Department Visits, 2008-2011 - Seeking Detox

Excel file with estimates, rates, relative standard errors, trends and confidence intervals for all drug-related emergency department (ED) visits involving patients seeking detox in the Fort Lauderdale division of the Miami metropolitan area, covering 2008-2011. This includes nonemergency requests made through the ED for admission to detoxification unit, visits to obtain medical clearance before being incarcerated, and acute emergencies where an individual is experiencing withdrawal symptoms and requests detox. These estimates do not include patients who seek or enter the hospital\'s detox unit through other avenues.

Tags: detoxification-seeking, drug-related-ed, miami-fort-lauderdale, samhsa, substance-use-trends
Organization: U.S. Department of Health & Human Services
Patent AT-E400924-T1: [Translated] METHOD FOR DYNAMIC SYMMETIZATION OF SERIES AND PARALLEL-CONNECTED POWER SEMICONDUCTOR SWITCHES

A method for dynamically balancing the loads in a circuit ( 1, 4 ) of semiconductor power switches arranged in series or in parallel is disclosed. Individual switching signals (i<SUB>G1</SUB>, i<SUB>G2</SUB>) for the semiconductor power switches (S<SUB>1 </SUB>. . . S<SUB>4</SUB>) are generated by determining a system-widely valid synchronous sampling time (ts<SUB>j</SUB>) independently for each semiconductor power switch (S<SUB>1 </SUB>. . . S<SUB>4</SUB>) due to a synchronous event (es) of the whole circuit ( 1, 4 ). Control loop offsets between actual values (a<SUB>i</SUB>) measured synchronously at the sampling time (ts<SUB>j</SUB>) and given desired values (a<SUB>s</SUB>) of an asynchronous state variable (a(t)) of the semiconductor power switches (S<SUB>1 </SUB>. . . S<SUB>4</SUB>) are reduced in the same or in following switching cycles. Alternatively, control loop offsets between actual time values (ta<SUB>i</SUB>) and desired time values (ta<SUB>s</SUB>) are minimized, wherein the actual time values (ta<SUB>i</SUB>) are measured upon exceeding a globally provided threshold value (epsilon<SUB>a</SUB>) of an asynchronous state variable (a(t)) of the semiconductor power switches (S<SUB>1 </SUB>. . . S<SUB>4</SUB>). Embodiments relate to: Offsetting the sampling time (ts<SUB>j</SUB>) in time by a globally provided time interval (Deltat 0 ), providing desired values locally or globally, e.g. by averaging of actual values (a<SUB>i</SUB>, ta<SUB>i</SUB>), additional balancing of the gradients of asynchronous time variables (a(t)). A central sampling command can be dispensed with and the switching synchronicity is improved, switching times are shortened and dynamic switching losses are reduced.

Tags: chemistry, innovation, patent, pubchem, research
Organization: U.S. Department of Health & Human Services
San Francisco – SF Div: Drug-Related Emergency Department Visits, 2004-2011 - All Alcohol

Excel file with estimates, rates, relative standard errors, trends and confidence intervals, covering 2004-2011 for emergency department visits involving alcohol in the San Francisco division of the San Francisco metropolitan area.  For adults aged 21 and older, the alcohol was found in combination with other drugs. For patients under the age of 21, the visit may involve alcohol alone or in combination with other drugs.File includes data for over 500 drugs, including illicit drugs, prescription and over-the-counter medications, dietary supplements, inhalants and alcohol.  Includes total visits, gender, age group, race/ethnicity, outcome of visit, drug combinations, number of drugs involved in visit, drug frequency, and drugs confirmed by toxicology.Additional detail is provided for illicit drugs, psychotherapeutic drugs, central nervous system (CNS) drugs, respiratory drugs and cardiovascular drugs.

Tags: alcohol-related-ed-visits, drug-overdose, emergency-department, samhsa, san-francisco
Organization: U.S. Department of Health & Human Services
Compound 528854: 5-Ethyl-7-pentyl-1,2,3,4,6-pentathiepane

Chemical compound data from PubChem database. IUPAC Name: 5-ethyl-7-pentyl-1,2,3,4,6-pentathiepane. Molecular Formula: C9H18S5. Molecular Weight: 286.6. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 527518: Nonyl 2-bromopropanoate

Chemical compound data from PubChem database. IUPAC Name: nonyl 2-bromopropanoate. Molecular Formula: C12H23BrO2. Molecular Weight: 279.21. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 529796: Leucine, trifluoroacetyl-isopropyl ester

Chemical compound data from PubChem database. IUPAC Name: propan-2-yl 4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentanoate. Molecular Formula: C11H18F3NO3. Molecular Weight: 269.26. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 528216: Benzoic acid, 3,4-dihydroxy, methyl ester, DTBS

Chemical compound data from PubChem database. IUPAC Name: methyl 2,2-ditert-butyl-1,3,2-benzodioxasilole-5-carboxylate. Molecular Formula: C16H24O4Si. Molecular Weight: 308.44. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 530289: Tetrapropylsilane

Chemical compound data from PubChem database. IUPAC Name: tetrapropylsilane. Molecular Formula: C12H28Si. Molecular Weight: 200.44. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2013 CMHS Uniform Reporting System (URS) Table for New Mexico

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Tables for New Mexico for 2013. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program.  State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: behavioral-health-new-mexico, community-mental-health, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
National Youth in Transition Database Data Brief #6

This brief presents the latest findings from NYTD surveys completed by youth in NYTD Cohort 2 at age 19 (in FY 16). The brief also presents select comparisons of results between Cohort 1 and Cohort 2 youth at ages 17 and 19.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: assessment, data, policy, reporting, youth
Organization: U.S. Department of Health & Human Services
Compound 525062: Agn-PC-0jsc21

Chemical compound data from PubChem database. IUPAC Name: methyl 10-hydroxydec-8-enoate. Molecular Formula: C11H20O3. Molecular Weight: 200.27. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Reassignment of specificities of two cap methyltransferase domains in the reovirus lambda2  protein

Background
          The reovirus λ2 protein catalyzes mRNA capping, that is, addition of a guanosine to the 5' end of each transcript in a 5'-to-5' orientation, as well as transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to the N7 atom of the added guanosyl moiety and subsequently to the ribose 2'-O atom of the first template-encoded nucleotide. The structure of the human reovirus core has been solved at 3.6 Å resolution, revealing a series of domains that include a putative guanylyltransferase domain and two putative methyltransferase (MTase) domains. It has been suggested that the order of domains in the λ2 protein corresponds to the order of reactions in the pathway and that the m7G (cap 0) and the 2'-O-ribose (cap 1) MTase activities may be exerted by the MTase 1 and the MTase 2 domains, respectively.
        
        
          Results
          We show that the reovirus MTase 1 domain shares a putative active site with the structurally characterized 2'-O-ribose MTases, including vaccinia virus cap 1 MTase, whereas the MTase 2 domain is structurally similar to glycine N-MTase.
        
        
          Conclusions
          On the basis of our analysis of the structural details we propose that the previously suggested functional assignments of the MTase 1 and MTase 2 domains should be swapped.

Tags: methyltransferase-domains, mrna-capping, nih, reovirus, reovirus-lambda2
Organization: U.S. Department of Health & Human Services
Compound 527642: Heptyl 2-chlorobutanoate

Chemical compound data from PubChem database. IUPAC Name: heptyl 2-chlorobutanoate. Molecular Formula: C11H21ClO2. Molecular Weight: 220.73. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2012 Uniform Reporting System (URS) Tables for District of Columbia

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2012. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-program, community-mental-health, mental-health-services, outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Compound 525132: 2,4,5-Trimethoxy-6-(methoxymethyl)-3-[3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxyoxane

Chemical compound data from PubChem database. IUPAC Name: 2,4,5-trimethoxy-6-(methoxymethyl)-3-[3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxyoxane. Molecular Formula: C20H38O11. Molecular Weight: 454.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Region 3, Volume 6

This is a behavioral health report for HHS Region III of the United States and utilizes data from the National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment (N-SSATS), collected annually. The topics addressed in the reports include youth substance use, adult mental health and treatment, and substance use treatment.

Tags: behavioral-health, mental-health, samhsa, substance-use, treatment-data
Organization: U.S. Department of Health & Human Services
Compound 528870: Methyl 3,4-dimethyl-2-thienyl disulfide

Chemical compound data from PubChem database. IUPAC Name: 3,4-dimethyl-2-methylsulfanylthiophene. Molecular Formula: C7H10S2. Molecular Weight: 158.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 530464: o-Toluic acid, 1-adamantylmethyl ester

Chemical compound data from PubChem database. IUPAC Name: 1-adamantylmethyl 2-methylbenzoate. Molecular Formula: C19H24O2. Molecular Weight: 284.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 528498: 6-Methylheptadecane

Chemical compound data from PubChem database. IUPAC Name: 6-methylheptadecane. Molecular Formula: C18H38. Molecular Weight: 254.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Resource use data by patient report or hospital records: Do they agree?

Background
          Economic evaluations alongside clinical trials are becoming increasingly common. Cost data are often collected through the use of postal questionnaires; however, the accuracy of this method is uncertain. We compared postal questionnaires with hospital records for collecting data on physiotherapy service use.
        
        
          Methods
          As part of a randomised trial of orthopaedic medicine compared with orthopaedic surgery we collected physiotherapy use data on a group of patients from retrospective postal questionnaires and from hospital records.
        
        
          Results
          315 patients were referred for physiotherapy. Hospital data on attendances was available for 30% (n = 96), compared with 48% (n = 150) of patients completing questionnaire data (95% Cl for difference = 10% to 24%); 19% (n = 59) had data available from both sources. The two methods produced an intraclass correlation coefficient of 0.54 (95% Cl 0.31 to 0.70). However, the two methods produced significantly different estimates of resource use with patient self report recalling a mean of 1.3 extra visits (95% Cl 0.4 to 2.2) compared with hospital records.
        
        
          Conclusions
          Using questionnaires in this study produced data on a greater number of patients compared with examination of hospital records. However, the two data sources did differ in the quantity of physiotherapy used and this should be taken into account in any analysis.

Tags: data-agreement, hospital-records, nih, patient-reported-outcomes, physiotherapy-utilization
Organization: U.S. Department of Health & Human Services
Challenges and Benefits of Modular System Development

This webinar examines the benefits - as well as the mysteries - of modularity when designing a system. The speakers present the basics of modular system development, including when, how, and why to choose modular design. They also highlight Connecticut’s experience with modular development, including the challenges, risks, issues, outcomes, and lessons learned.

This webinar was facilitated by Joyce Rose, a consultant to ICF. The presenters include the following individuals:

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: design, policy, program, public, system
Organization: U.S. Department of Health & Human Services
Compound 528262: Butanedioic acid, heptyl phenylmethyl ester

Chemical compound data from PubChem database. IUPAC Name: 4-O-benzyl 1-O-heptyl butanedioate. Molecular Formula: C18H26O4. Molecular Weight: 306.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2012 State Profile - Georgia

This is a National Survey of Substance Abuse Treatment Services (N-SSATS) annual report showing the state profile for Georgia in 2012. N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 States, the District of Columbia, and other U.S. jurisdictions.

Tags: georgia, n-ssats, samhsa, substance-abuse-treatment, treatment-facilities
Organization: U.S. Department of Health & Human Services
Compound 529326: Oxetane, 3-methyl-3-(2-methyl-1-[3-methylphenyloxy)propyl]

Chemical compound data from PubChem database. IUPAC Name: 3-methyl-3-[2-methyl-1-(3-methylphenoxy)propyl]oxetane. Molecular Formula: C15H22O2. Molecular Weight: 234.33. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 528243: 2-Butyl-3,5-dimethylthiophene

Chemical compound data from PubChem database. IUPAC Name: 2-butyl-3,5-dimethylthiophene. Molecular Formula: C10H16S. Molecular Weight: 168.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Annotated Bibliography Informing Training and Technical Assistance

To support the Permanency Innovations Initiative (PII) Grantees in better meeting the needs of children and families, the PII Training and Technical Assistance Project (PII-TTAP) team created the Annotated Bibliography Informing Training and Technical Assistance. PII-TTAP conducted extensive research to develop and refine the Development, Implementation, and Assessment Approach and organized the research into an annotated bibliography related to organizational and system development, change management, leadership, and implementation science.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: child, family, grant, policy, program
Organization: U.S. Department of Health & Human Services
2019 Uniform Reporting System (URS) Table for Alabama

These are the 2019 Uniform Reporting System (URS) Output Tables for Alabama. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: alabama-mental-health, mental-health-services, national-outcome-measures, samhsa, substance-abuse-treatment
Organization: U.S. Department of Health & Human Services
Is there a role for glucocorticoid receptor beta in asthma?

Glucocorticoids (GCs) are routinely used as anti-inflammatory drugs in the treatment of asthma. They act through binding to glucocorticoid receptor α (GRα), which represses numerous genes encoding pro-inflammatory mediators. A hormone binding deficient GR isoform named GRβ has been isolated in humans. When overexpressed by transfection, GRβ may function as a dominant negative modulator of GRα. However, to act as such, GRβ has to be more abundant than GRα, and conflicting data have been obtained concerning the relative levels of the two isoforms in cell lines and freshly isolated cells. Moreover, the dominant negative effect was not confirmed by independent laboratories. In GC-resistant asthmatics, GRβ was expressed by an increased number of peripheral blood mononuclear cells (PBMCs), airway T cells, and cells found in skin biopsies of tuberculin responses. However, the relative amounts of GRα and GRβ in these cells were not determined. In GC-dependent asthmatics, PBMCs expressed GRα predominantly. No cells containing higher levels of GRβ than GRα have yet been reported in asthmatics. Even if the existence of such cells is demonstrated, the role of GRβ in asthma will remain a matter of controversy because functional studies have given discrepant data.

Tags: anti-inflammatory-drugs, asthma-glucocorticoids, glucocorticoid-receptor, nih, steroid-resistance
Organization: U.S. Department of Health & Human Services