AndreaBozzo/ceres-open-data-index huggingface dataset:
Observations on morphologic changes in the aging and degenerating human disc: Secondary collagen alterations

Background
          In the annulus, collagen fibers that make up the lamellae have a wavy, planar crimped pattern. This crimping plays a role in disc biomechanical function by allowing collagen fibers to stretch during compression. The relationship between morphologic changes in the aging/degenerating disc and collagen crimping have not been explored.
        
        
          Methods
          Ultrastructural studies were performed on annulus tissue from 29 control (normal) donors (aged newborn to 79 years) and surgical specimens from 49 patients (aged 16 to 77 years). Light microscopy and specialized image analysis to visualize crimping was performed on additional control and surgical specimens. Human intervertebral disc tissue from the annulus was obtained in a prospective morphologic study of the annulus. Studies were approved by the authors' Human Subjects Institutional Review Board.
        
        
          Results
          Three types of morphologic changes were found to alter the crimping morphology of collagen: 1) encircling layers of unusual matrix disrupted the lamellar collagen architecture; 2) collagen fibers were reduced in amount, and 3) collagen was absent in regions with focal matrix loss.
        
        
          Conclusions
          Although proteoglycan loss is well recognized as playing a role in the decreased shock absorber function of the aging/degenerating disc, collagen changes have received little attention. This study suggests that important stretch responses of collagen made possible by collagen crimping may be markedly altered by morphologic changes during aging/degeneration and may contribute to the early tissue changes involved in annular tears.

Tags: aging-disc, collagen-alterations, disc-degeneration, intervertebral-disc, nih
Organization: U.S. Department of Health & Human Services
Comparison of the sensitivity of a 24 h-shell vial assay, and conventional tube culture, in the isolation of Herpes simplex virus – 1 from corneal scrapings

Background
          Herpes simplex keratitis is a sight threatening ocular infection. A rapid and specific diagnosis is essential for the institution of specific antiviral therapy and to avoid complications that can arise from misdiagnosis and inappropriate treatment. Though a variety of techniques are available, isolation of Herpes simplex virus 1 (HSV-1) in culture provides the most reliable and specific method, and is considered as the gold standard in laboratory diagnosis of herpes simplex keratitis. We report a comparative study of the sensitivity of a 24 h-shell vial assay and conventional tube culture in the isolation of HSV-1 from corneal scrapings.
        
        
          Methods
          A total of 74 corneal scrapings obtained from 74 patients with a clinical suspicion of herpes simplex keratitis submitted for the isolation of HSV-1, were simultaneously inoculated into shell vial and tube cultures employing the vero cell line. Shell vial and tube cultures were terminated at 24 h and fifth day respectively. Isolation of HSV-1 was confirmed employing an indirect immunofluorescence assay.
        
        
          Results
          HSV-1 was isolated from 24/74 (32.4%) specimens employing both the methods. Sensitivity of both the techniques were found to be similar (20/24, 83.3%) (P = 1.0).
        
        
          Conclusion
          A 24 h-shell vial assay is a rapid alternative technique in comparison to the time consuming conventional tube cultures for the isolation of HSV-1, especially from corneal scrapings for the laboratory diagnosis of herpes simplex keratitis.

Tags: corneal-scrapings, herpes-simplex-keratitis, hsv-1-isolation, nih, shell-vial-assay
Organization: U.S. Department of Health & Human Services
Compound 525046: Quininic acid (5TMS)

Chemical compound data from PubChem database. IUPAC Name: trimethylsilyl 1,3,4,5-tetrakis(trimethylsilyloxy)cyclohexane-1-carboxylate. Molecular Formula: C22H52O6Si5. Molecular Weight: 553.1. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2021 Uniform Reporting System (URS) Table For North Carolina

This is the 2021 Uniform Reporting System (URS) Output Tables for North Carolina. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-data, mental-health-services, national-outcome-measures, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
Compound 525364: 2,3-Dimethyl-4-thiaheptane

Chemical compound data from PubChem database. IUPAC Name: 2-methyl-3-propylsulfanylbutane. Molecular Formula: C8H18S. Molecular Weight: 146.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2011-2012 NSDUH State Prevalence Estimates - PDF Tables (for printing)

2011-2012 NSDUH State Prevalence Estimates – PDF Tables formatted for printing. Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Results are provided by State and for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: mental-illness-prevalence, samhsa, state-level-data, substance-use, suicidal-ideation
Organization: U.S. Department of Health & Human Services
Pharmacokinetics of artesunate after single oral administration to rats

Background
          Artesunate is a commonly used antimalarial drug derived from artemisinin. It is rapidly converted to dihydroartemisinin. Little is known on this conversion in the GI tract and blood, and how this influences absorption. In order to study the absorption phase of the kinetics of artesunate following oral administration in rats, samples were collected at baseline, and then 0.5, 2, 5, 10, 15, 30, 45, 60 and 120 minutes after a single dose of 150 mg.
        
        
          Results
          Peak concentration of parent artesunate and dihydroartemisinin was achieved within 5 and 37.5 +/- 8.7 min, respectively of start of administration through gavage. The half lives of absorption were 2.73 +/- 0.85 and 12.49 +/- 2.49 min, respectively.
        
        
          Conclusions
          These times were considerably shorter for artesunate than those found in studies which start sampling later. The profiles of parent compound and metabolite result from a complex equation dictated by the pH-dependent rates of hydroxylation of artesunate to dihydroartemisinin, the different rates at which either compounds are absorbed, and the catalytic hydroxylation by esterases. The rate of chemical oxidation of artesunate is pH dependent; this explains its rapid conversion to dihydroartemisinin in the stomach, as compared to its greater stability in other compartments at higher pH and in plasma. We propose that variable proportions of absorption take place in the stomach, and conclude that parent artesunate reaches an early peak within minutes of dosing, and that the early dihydroartemisinin levels result primarily from the absorption of the metabolite as such.

Tags: antimalarial-drug, artesunate-pharmacokinetics, dihydroartemisinin, nih, rat-model
Organization: U.S. Department of Health & Human Services
Treatment Episode Data Set (TEDS): 1999-2009, National Admissions to Substance Abuse Treatment Services

This report presents data from the Treatment Episode Data Set (TEDS) for 2009, and trend data for 1999 to 2009. The report provides information on the demographic and substance abuse characteristics of people aged 12 and older admitted to treatment for abuse of alcohol and/or drugs in facilities that report to individual state administrative data systems.

Tags: alcohol-drug-abuse, samhsa, substance-abuse-treatment, teds-data, treatment-admissions
Organization: U.S. Department of Health & Human Services
New Mexico 2016 Potential Areas for Addressing Service Gaps for Opioid Treatment

The purpose of the medication-assisted treatment (MAT) facility maps is to identify areas on a state-by-state basis that may be potentially underserved by existing treatment facilities. The maps are created with a methodology that seeks to include the highest potential need areas from individual counties so that county-level stakeholders are also informed. The maps are meant to be used as a tool for policy makers to determine potentially underserved areas—not as a definitive representation of these areas.

Tags: medication-assisted-treatment, new-mexico, opioid-treatment, samhsa, service-gap-analysis
Organization: U.S. Department of Health & Human Services
Compound 528425: Flavanone, 3,5,7-trihydroxy, tris-TMS

Chemical compound data from PubChem database. IUPAC Name: 2-phenyl-3,5,7-tris(trimethylsilyloxy)-2,3-dihydrochromen-4-one. Molecular Formula: C24H36O5Si3. Molecular Weight: 488.8. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Impact of HIV vaccination on laboratory diagnosis: case reports

Background
          It has not been clearly demonstrated whether HIV vaccination can complicate routine HIV testing. In this report, we describe the laboratory data of two prisoners who received rgp120 vaccine in a phase III trial underway in Thailand. These data indicate that previous vaccination may complicate the interpretation of screening HIV diagnostic tests.
        
        
          Case presentation
          The participants were identified from a cohort study on "Health factors related to HIV-1 and other viral infections among incarcerated people" that was approved by The Ethical Committee for Research in Human Subjects, Ministry of Public Health, Thailand. HIV diagnosis was definitively established with serial specimens using multi-screening tests, Western blot and diagnostic PCR.
          Anti-HIV screening tests consistently exhibited either weakly reactive or inconclusive results. The band patterns of the Western blot analysis corresponded to those found in individuals who received the rgp120 vaccination. Definite results were established using diagnostic PCR, which exhibited consistently negative results with follow-up specimens. Such problems in HIV testing are not easily resolved in the routine clinical setting in Thailand.
        
        
          Conclusions
          These data demonstrate that HIV-1 vaccination interferes with routine diagnostic tests. Similar cases will not be uncommon in Thailand, where 2,545 people have already participated in a phase III trial.

Tags: hiv-testing, hiv-vaccination, nih, rgp120-vaccine, western-blot
Organization: U.S. Department of Health & Human Services
Youth Mental Health Tables (Prevalence Estimates) - 2.1 to 2.14

These are the detailed tables pertaining to adult mental health from the 2011 National Survey on Drug Use and Health (NSDUH). These detailed tables present totals and prevalence estimates for youths include major depressive episode (MDE), treatment for depression (among youths with MDE), mental health service utilization, and measures related to the co-occurrence of mental disorders with substance use or with substance use disorders. Results are provided for age group, gender, race/ethnicity, education level, government assistance status, poverty level, geographic area, insurance status. Comparisons are made between 2011 and 2002 to 2010.

Tags: major-depressive-episode, mental-health-services, samhsa, substance-use-disorders, youth-mental-health
Organization: U.S. Department of Health & Human Services
Title IV-E Programs Expenditure and Caseload Data 2020

The Children’s Bureau posts an annual FY summary of Form CB-496 expenditures and caseloads as reported by each title IV-E agency. These data tables include the combination of current-quarter and prior-quarter adjustment expenditures and current-quarter caseload data as delineated in quarterly Form CB-496 submissions for FY 2020.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: data, policy, real, reporting, time
Organization: U.S. Department of Health & Human Services
Mental Health United States 2010

This publication provides behavioral health statistics at the national and state levels from multiple data sources, including the National Survey on Drug Use and Health, the National Health Interview Survey, the Medical Expenditures Panel Survey, the National Association of State Mental Health Program Directors, as well as peer-reviewed journal articles.

Tags: behavioral-health, mental-health-indicators, mental-health-statistics, national-survey, samhsa
Organization: U.S. Department of Health & Human Services
Evolutionary conservation of

Background
          Homeobox genes of the orthodenticle (otd)/Otx family have conserved roles in the embryogenesis of head and brain. Gene replacement experiments show that the Drosophila otd gene and orthologous mammalian Otx genes are functionally equivalent, in that overexpression of either gene in null mutants of Drosophila or mouse can restore defects in cephalic and brain development. This suggests that otd and Otx genes control a comparable subset of downstream target genes in either organism. Here we use quantitative transcript imaging to analyze this equivalence of otd and Otx gene action at a genomic level.
        
        
          Results
          Oligonucleotide arrays representing 13,400 annotated Drosophila genes were used to study differential gene expression in flies in which either the Drosophila otd gene or the human Otx2 gene was overexpressed. Two hundred and eighty-seven identified transcripts showed highly significant changes in expression levels in response to otd overexpression, and 682 identified transcripts showed highly significant changes in expression levels in response to Otx2 overexpression. Among these, 93 showed differential expression changes following overexpression of either otd or Otx2, and for 90 of these, comparable changes were observed under both experimental conditions. We postulate that these transcripts are common downstream targets of the fly otd gene and the human Otx2 gene in Drosophila.
        
        
          Conclusion
          Our experiments indicate that approximately one third of the otd-regulated transcripts also respond to overexpression of the human Otx2 gene in Drosophila. These common otd/Otx2 downstream genes are likely to represent the molecular basis of the functional equivalence of otd and Otx2 gene action in Drosophila.

Tags: brain-development, drosophila, gene-expression, homeobox-genes, nih
Organization: U.S. Department of Health & Human Services
Use of diffusion and perfusion magnetic resonance imaging as a tool in acute stroke clinical trials

In light of the slow progress in developing effective therapies for ischemic stroke, magnetic resonance imaging techniques have emerged as new tools in stroke clinical trials. Rapid imaging with magnetic resonance imaging, diffusion weighted imaging, perfusion imaging and angiography are being incorporated into phase II and phase III stroke trials to optimize patient selection based on positive imaging diagnosis of the ischemic pathophysiology specifically related to a drug's mechanism of action and as a direct biomarker of the effect of a treatment's effect on the brain.

Tags: clinical-trials, diffusion-weighted-imaging, ischemic-stroke, magnetic-resonance-imaging, nih
Organization: U.S. Department of Health & Human Services
2019 Uniform Reporting System (URS) Table for Alaska

These are the 2019 Uniform Reporting System (URS) Output Tables for Alaska. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: alaska-mental-health, block-grant-data, mental-health-services, noms-measures, samhsa
Organization: U.S. Department of Health & Human Services
Compound 525547: 3-Methyl-1,6,8-tris[(trimethylsilyl)oxy]anthra-9,10-quinone

Chemical compound data from PubChem database. IUPAC Name: 3-methyl-1,6,8-tris(trimethylsilyloxy)anthracene-9,10-dione. Molecular Formula: C24H34O5Si3. Molecular Weight: 486.8. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2017-2018 NSDUH State Estimates Of Substance Use And Mental Disorders

These are the state-level estimates for combined 2017 and 2018 NSDUHs. Part 1 is released in late November and part 2 in February after the close of the NSDUH data collection.

Tags: mental-disorders, nsduh-survey, samhsa, state-level-estimates, substance-use
Organization: U.S. Department of Health & Human Services
2017-2018 NSDUH: Other Sources Of State-Level Data

This document briefly describes one of these other data systems that publish state estimates and presents selected comparisons with NSDUH results: Behavioral Risk Factor Surveillance System (BRFSS) and Youth Risk Behavior Survey (YRBS).

Tags: behavioral-risk-factors, brfss-comparison, samhsa, substance-use-estimates, yrbs-comparison
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Iowa, 2013

This is a behavioral health report for the state of Iowa. It uses the  National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment Services (NSSATS) to address the topics of youth substance use , youth mental health and treatment, adult mental health and treatment, substance use, substance use treatment for the years 2008 to 2012.

Tags: adult-mental-health, iowa-behavioral-health, samhsa, substance-abuse-treatment, youth-substance-use
Organization: U.S. Department of Health & Human Services
The therapeutic potential of modulators of the Hedgehog-Gli signaling pathway

The discovery of small molecules that act as agonists and antagonists of the Hedgehog-Gli signaling pathway, which plays important roles in the embryo and adult, opens a new avenue for the treatment of diseases caused by aberrant suppression or activation of this complex pathway.

Tags: gli-pathway, hedgehog-signaling, nih, small-molecules, therapeutic-potential
Organization: U.S. Department of Health & Human Services
ICU Cornestone: A lecture that changed my practice

In 1982, the author attended a lecture by Professor Joseph Civetta dealing with the concept that, at times, the goal of care should be comfort rather than cure, and that inappropriate care prolonged dying and suffering. Efforts to improve end-of-life care subsequent to this had effects on care at a local level and at a state level. Intensive care providers should be leaders in the provision of appropriate and compassionate care at the end of life.

Tags: comfort-care, end-of-life-care, icu-patients, nih, palliative-care
Organization: U.S. Department of Health & Human Services
Are the Cochrane group registers comprehensive? A case study of Japanese psychiatry trials

Background
          Language bias is a form of publication bias and constitutes a serious threat to meta-analyses. The Cochrane Controlled Trials Register is one attempt to remedy this and now contains more than 300,000 citations. However we are still unsure if it provides comprehensive coverage, particularly for non-English trials.
        
        
          Methods
          We have recently established a comprehensive register of Japanese trials of psychotropic drugs through extensive personal contacts, electronic searches and handsearches. We examined two Cochrane psychiatry group registers against this Japanese database.
        
        
          Results
          The Japanese register contained 56 reports of randomized controlled trials (RCTs) of antidepressants for depression but the Cochrane Depression, Anxiety and Neurosis group register contained 18, with an overlap of only nine. The Japanese register contained 61 reports of RCTs of neuroleptics for schizophrenia and the Cochrane Schizophrenia group register contained 36, with an overlap of only six. Taking account of some duplicate publications, only a quarter to a third of all relevant Japanese RCTs were retrievable from the Cochrane group registers.
        
        
          Conclusions
          Similar, or worse, yields may be expected with RCTs conducted in other East Asian countries, and in other fields of medicine. What evidence there is suggests that this situation may lead to a systematic over estimate of treatment effect.

Tags: antidepressants, japanese-trials, nih, psychiatry-trials, publication-bias
Organization: U.S. Department of Health & Human Services
Isolation and characterization of rheumatoid arthritis synovial fibroblasts from primary culture — primary culture cells markedly differ from fourth-passage cells

To reduce culture artifacts by conventional repeated passaging and long-term culture in vitro, the isolation of synovial fibroblasts (SFB) was attempted from rheumatoid arthritis (RA) synovial membranes by trypsin/collagenase digest, short-term in vitro adherence (7 days), and negative isolation using magnetobead-coupled anti-CD14 monoclonal antibodies. This method yielded highly enriched SFB (85% prolyl-4-hydroxylase+/74% Thy-1/CD90+ cells; <2% contaminating macrophages; <1% leukocytes/endothelial cells) that, in comparison with conventional fourth-passage RA-SFB, showed a markedly different phenotype and significantly lower proliferation rates upon stimulation with platelet-derived growth factor and IL-1β. This isolation method is simple and reliable, and may yield cells with features closer to the in vivo configuration of RA-SFB by avoiding extended in vitro culture.

Tags: cell-culture, nih, primary-cell-isolation, rheumatoid-arthritis, synovial-fibroblasts
Organization: U.S. Department of Health & Human Services
NYTD Technical Assistance to States

Tailored technical assistance (TA) is available to states that are working with the Children’s Bureau to plan for their NYTD Review on ways to engage young adults (ages 18−25) with current or former foster care experience to participate as a state NYTD Reviewer (called State Youth Ambassador) and in their state’s ongoing NYTD efforts. The goal is to build capacity within the state through the involvement of young people in their NYTD and CQI efforts.

General TA support available:

To schedule a NYTD Review TA call, please contact our TA team by emailing the Child Welfare Compliance Reviews Team at cw@jbsinternational.com, Subject: NYTD TA

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: care, foster, grant, policy, real
Organization: U.S. Department of Health & Human Services