AndreaBozzo/ceres-open-data-index huggingface dataset:
Washoe County PII SAFE-FC PCFA-SMART Case Planning Fidelity Assessment

An overview of the degree to which the Washoe County, Nevada Permanency Innovations Initiative (PII) site implemented SAFE-FC as intended, and the degree to which individual SAFE-FC workers demonstrated proficiency in delivering the PCFA, safety management, and SMART case planning components of SAFE-FC.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: assessment, child, policy, real, time
Organization: U.S. Department of Health & Human Services
Long terminal repeat retrotransposons of

A new data-mining program, LTR_STRUC, was used to mine the GenBank rice (Oryza sativa) database as well as the more extensive Monsanto rice dataset for long terminal repeat retrotransposons. Each of the major clades of rice LTR retrotransposons is more closely related to elements present in other species than to the other clades of rice elements, suggesting that horizontal transfer may have occurred.

Tags: horizontal-transfer, nih, oryza-sativa, retrotransposons, rice-genome
Organization: U.S. Department of Health & Human Services
New immunosuppressive drugs in heart transplantation

Only a few randomized clinical trials have been performed so far in heart transplant recipients, mainly because of the relatively small number of heart transplants performed worldwide each year. The main focus of the few controlled trials that have been completed has been the prevention and treatment of heart allograft rejection. In the area of pharmacologic immunosuppression, both biological agents and drugs have been the subject of investigation. Among the biological agents, chimeric monoclonal antibodies directed against the interleukin (IL)-2 receptor, which have been found to be safe and effective in renal transplant recipients, are now undergoing the test of controlled trials in heart transplant recipients. Immunosuppressive drugs that have been studied in controlled trials include calcineurin inhibitors (such as the microemulsion formulation of cyclosporine and tacrolimus) and inhibitors of purine synthesis, such as mycophenolate mofetil. Non-pharmacologic prophylactic immunosuppression with photopheresis has also been tested in a prospective, multicenter, randomized trial. New immunosuppressive regimens, such as mycophenolate mofetil combined with a monoclonal antibody against the IL-2 receptor, are being tested with the aim to reduce or eliminate calcineurin inhibitors or corticosteroids. Although clinical approaches to the induction of tolerance have undergone preliminary clinical evaluation, the ability to induce tolerance to an allograft in humans remains an elusive goal.

Tags: allograft-rejection, clinical-trials, heart-transplantation, immunosuppressive-drugs, nih
Organization: U.S. Department of Health & Human Services
Patent AT-E399589-T1: [Translated] LIQUID MIXING DEVICE

A mixer apparatus for use with a vessel centered about a longitudinal axis is disclosed. The mixer has a tubular blade which: defines a central head axis; has a first end and a second end spaced from the first end along the head axis; and tapers from the first end to the second end. The outer surface of the blade and the second end define an inside blade diameter "ID" and the outer surface of the blade and the first end define an outside blade diameter "OD". The blade is positioned within and coaxial to the vessel. A scotch yoke, operatively connected to the blade by a shaft, effects reciprocating longitudinal movement of the blade through a stroke "S", with a duration "T" for each stroke, wherein 175≲0.36 xOD<SUP>2</SUP>/ID<SUP>2</SUP>xS/T≲ 250 when OD, ID and S are expressed in inches, and T is expressed in minutes.

Tags: chemistry, innovation, patent, pubchem, research
Organization: U.S. Department of Health & Human Services
Virginia (VA)

This report uses 2008 to 2010 National Survey on Drug Use and Health (NSDUH) to assess past year alcohol use disorder and illicit drug use disorder among persons aged 12 or older for Virginia overall and for substate regions within Virginia. Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE).

Tags: mental-health-indicators, nsduh-data, samhsa, substance-use-disorder, virginia-health
Organization: U.S. Department of Health & Human Services
Patent AT-E400222-T1: [Translated] SURGICAL INSTRUMENTS FOR DELIVERING MEDICINAL PRODUCTS

A medical agent dispensing system can be provided that may be structured for use with a surgical severing/stapling instrument (10) that is designed for severing and stapling tissue. The dispensing system may include at least one storage reservoir (92,94) structured for storing at least a component of a medical agent; a gear pump casing (72) in communication with the storage reservoir; a screw pump auger (76) positioned within the gear pump casing capable of rotational manipulation to move the medical agent through the gear pump casing; and, at least one agent tube (78,80) in communication with the gear pump casing. The agent tube may be structured for communication with at least one agent port (82,84,86) formed in a staple cartridge of the surgical instrument for dispensing the medical agent therethrough.

Tags: chemistry, innovation, patent, pubchem, research
Organization: U.S. Department of Health & Human Services
Compound 527993: Propanoic acid, 2,2-dichloro-, heptyl ester

Chemical compound data from PubChem database. IUPAC Name: heptyl 2,2-dichloropropanoate. Molecular Formula: C10H18Cl2O2. Molecular Weight: 241.15. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Vitamin D receptor initiation codon polymorphism influences genetic susceptibility to type 1 diabetes mellitus in the Japanese population

Background
          Vitamin D has been shown to exert manifold immunomodulatory effects. Type 1 diabetes mellitus (T1DM) is regarded to be immune-mediated and vitamin D prevents the development of diabetes in the NOD mouse. We studied the association between T1DM and the initiation codon polymorphism in exon 2 of the vitamin D receptor gene in a Japanese population. We also investigated associations between the vitamin D receptor polymorphism and GAD65-antibody (Ab) positivity. We carried out polymerase chain reaction-restriction fragment length polymorphism analysis in 110 Japanese T1DM patients and 250 control subjects. GAD65 antibodies were assessed in 78 patients with T1DM.
        
        
          Results
          We found a significantly higher prevalence of the F allele / the FF genotype in the patients compared to the controls (P = 0.0069 and P = 0.014, respectively). Genotype and allele frequencies differed significantly between GAD65-Ab-positive patients and controls (P = 0.017 and P = 0.012, respectively), but neither between GAD65-Ab-negative patients and controls (P = 0.68 and P = 0.66, respectively) nor between GAD65-Ab-positive and -negative patients (P = 0.19 and P = 0.16, respectively).
        
        
          Conclusions
          Our findings suggest that the vitamin D receptor initiation codon polymorphism influences genetic susceptibility to T1DM among the Japanese. This polymorphism is also associated with GAD65-Ab-positive T1DM, although the absence of a significant difference between GAD65-Ab-negative patients and controls might be simply due to the small sample size of patients tested for GAD65 antibodies.

Tags: genetic-susceptibility, japanese-population, nih, type-1-diabetes, vitamin-d-receptor
Organization: U.S. Department of Health & Human Services
Compound 527856: 1-Chloro-2-methylpentane

Chemical compound data from PubChem database. IUPAC Name: 1-chloro-2-methylpentane. Molecular Formula: C6H13Cl. Molecular Weight: 120.62. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 528411: 5-Methyloxazole

Chemical compound data from PubChem database. IUPAC Name: 5-methyl-1,3-oxazole. Molecular Formula: C4H5NO. Molecular Weight: 83.09. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 528609: Butanamide, N-tert.-butyl-3-methyl

Chemical compound data from PubChem database. IUPAC Name: N-tert-butyl-3-methylbutanamide. Molecular Formula: C9H19NO. Molecular Weight: 157.25. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Acquisition of tolerance against oxidative damage in

Background
          Living cells constantly sense and adapt to redox shifts by the induction of genes whose products act to maintain the cellular redox environment. In the eukaryote Saccharomyces cerevisiae, while stationary cells possess a degree of constitutive resistance towards oxidants, treatment of exponential phase cultures with sub-lethal stresses can lead to the transient induction of protection against subsequent lethal oxidant conditions. The sensors of oxidative stress and the corresponding transcription factors that activate gene expression under these conditions have not yet been completely identified.
        
        
          Results
          We report the role of SOD1, SOD2 and TPS1 genes (which encode the cytoplasmic Cu/Zn-superoxide dismutase, the mitochondrial Mn-isoform and trehalose-6-phosphate synthase, respectively) in the development of resistance to oxidative stress. In all experimental conditions, the cultures were divided into two parts, one was immediately submitted to severe stress (namely: exposure to H2O2, heat shock or ethanol stress) while the other was initially adapted to 40°C for 60 min. The deficiency in trehalose synthesis did not impair the acquisition of tolerance to H2O2, but this disaccharide played an essential role in tolerance against heat and ethanol stresses. We also verified that the presence of only one Sodp isoform was sufficient to improve cellular resistance to 5 mM H2O2. On the other hand, while the lack of Sod2p caused high cell sensitivity to ethanol and heat shock, the absence of Sod1p seemed to be beneficial to the process of acquisition of tolerance to these adverse conditions. The increase in oxidation-dependent fluorescence of crude extracts of sod1 mutant cells upon incubation at 40°C was approximately 2-fold higher than in sod2 and control strain extracts. Furthermore, in Western blots, we observed that sod mutants showed a different pattern of Hsp104p and Hsp26p expression also different from that in their control strain.
        
        
          Conclusions
          Trehalose seemed not to be essential in the acquisition of tolerance to H2O2 stress, but its absence was strongly felt under water stress conditions such as heat and alcoholic stresses. On the other hand, Sod1p could be involved in the control of ROS production; these reactive molecules could signal the induction of genes implicated within cell tolerance to heat and ethanol. The effects of this deletion needs further investigation.

Tags: nih, oxidative-stress, redox-regulation, saccharomyces-cerevisiae, stress-tolerance
Organization: U.S. Department of Health & Human Services
Patent AT-E401042-T1: [Translated] METHOD AND DEVICE FOR EXTERNAL CARDIAC STABILIZATION

The present disclosure is directed to an external cardiac basal annuloplasty system (ECBAS or BACE-System: basal annuloplasty of the cardia externally) and methods for treatment of regurgitation of mitral and tricuspid valves. The BACE-System provides the ability to correct leakage of regurgitation of the valves with or without the use of cardiopulmonary bypass, particularly when the condition is related to dilation of the base of the heart. This ECBAS invention can be applied to the base of the heart epicardially, either to prevent further dilation or to actively reduce the size of the base of the heart.

Tags: chemistry, innovation, patent, pubchem, research
Organization: U.S. Department of Health & Human Services
Compound 528370: Nornicotine, N-hexanoyl

Chemical compound data from PubChem database. IUPAC Name: 1-(2-pyridin-3-ylpyrrolidin-1-yl)hexan-1-one. Molecular Formula: C15H22N2O. Molecular Weight: 246.35. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 525447: 3-Methyl-2,4-dithia-6-heptene

Chemical compound data from PubChem database. IUPAC Name: 3-(1-methylsulfanylethylsulfanyl)prop-1-ene. Molecular Formula: C6H12S2. Molecular Weight: 148.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 530028: Benzaldehyde, 3-methoxy-4-[(trimethylsilyl)oxy]-, O-methyloxime

Chemical compound data from PubChem database. IUPAC Name: N-methoxy-1-(3-methoxy-4-trimethylsilyloxyphenyl)methanimine. Molecular Formula: C12H19NO3Si. Molecular Weight: 253.37. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Do steroids prevent reintubation in children with laryngotracheobronchitis?

Background:
          Classic laryngotrachoebronchitis (LTB) is an inflammatory process, with oedema and secretions that involve the entire laryngotracheobronchial tree. The severity of lower airway disease in African children with LTB has previously been documented. The aim of the present study was to determine whether steroids prevent reintubation in African children with classic LTB.
        
        
          Method and results:
          The study was a retrospective analysis from January 1993 to December 1996. Eighty-two black children with LTB were mechanically ventilated in the intensive care unit (ICU). By univariate regression, the estimated B coefficients for variables such as age, pneumonia, days of intubation, arterial partial oxygen tension (PaO2) : fractional inspired oxygen (FIO2) ratio, atelectasis and antibiotic use were not statistically significant (P > 0.05) as predictors for reintubation. Using multiple regression (all independent variables in combination), none of the variables acted as predictors of reintubation (P = 0.25). Steroids were shown to have no effect alone or in association with other variables in altering reintubation rates. An increase in the days of intubation showed a tendency towards reintubation (P = 0.06) in the univariate analysis (odds ratio 1.00-1.14), but showed no statistically significant difference in multivariate analysis. Of the variables used as predictors of reintubation, none acted either as a preventive factor or as a risk factor.
        
        
          Conclusion:
          The present results suggest that steroids should not be recommended at any stage in treatment of intubated patients with classic LTB. Prospective studies should evaluate the major risk factors for reintubation: duration of intubation, trauma to the airway at intubation and during ICU stay, and dose and timing of steroids. They should also evaluate whether upper airway disease is present alone or in association with lower airway disease.

Tags: croup-management, laryngotracheobronchitis, nih, pediatric-reintubation, steroid-treatment
Organization: U.S. Department of Health & Human Services
Neighborhood and Household Factors in the Etiology of Child Maltreatment

Two complementary research components--structured interviews with and ethnographic studies of parents--will address the two primary issues of this study. The factors being examined are (1) the ways in which neighborhood characteristics are related to parental behaviors that increase or decrease the risk of child maltreatment and (2) the ways in which parental perceptions of the neighborhood affect child maltreatment. Neighborhoods categorized as at high risk, medium risk, and low risk for child abuse and neglect reports are included in the study.

Investigators: Korbin, Jill

Tags: abuse, care, ndacan, policy, reporting
Organization: U.S. Department of Health & Human Services
Compound 526713: 2-(2-(2-(2-(2-nonyloxy-ethoxy)-ethoxy)-ethoxy)-ethoxy)-ethanol, TFA

Chemical compound data from PubChem database. IUPAC Name: 2-[2-[2-[2-(2-nonoxyethoxy)ethoxy]ethoxy]ethoxy]ethyl 2,2,2-trifluoroacetate. Molecular Formula: C21H39F3O7. Molecular Weight: 460.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2022 Uniform Reporting System (URS) Table For Virginia

This is the 2022 Uniform Reporting System (URS) Output Tables for Virginia. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, evidence-based-practices, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Patent AT-E400496-T1: [Translated] UNDERWATER EXHAUST DEVICE

The device has an exhaust case (5) connected to a gas exhaust system via an exhaust pipe (4). The case is placed at the level of an exhaust outlet (7) that is situated on a hull of a ship and placed below water-line. The case is partially closed by a deflector (6) having width equal to two-third of the width of the outlet, and providing smooth profile to the hull.

Tags: chemistry, innovation, patent, pubchem, research
Organization: U.S. Department of Health & Human Services
Compound 527752: 2,2-Dichloroethyl butanoate

Chemical compound data from PubChem database. IUPAC Name: 2,2-dichloroethyl butanoate. Molecular Formula: C6H10Cl2O2. Molecular Weight: 185.05. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 530192: Imidazole-5-lactic acid, TMS

Chemical compound data from PubChem database. IUPAC Name: trimethylsilyl 3-(3-trimethylsilylimidazol-4-yl)-2-trimethylsilyloxypropanoate. Molecular Formula: C15H32N2O3Si3. Molecular Weight: 372.68. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 525366: 2,3-Dimethyl-4-thiaoctane

Chemical compound data from PubChem database. IUPAC Name: 2-butylsulfanyl-3-methylbutane. Molecular Formula: C9H20S. Molecular Weight: 160.32. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2022 Uniform Reporting System (URS) Table For Maryland

This is the 2022 Uniform Reporting System (URS) Output Tables for Maryland. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, maryland, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Compound 529944: 1-(Thiophen-3-yl)propan-1-one

Chemical compound data from PubChem database. IUPAC Name: 1-thiophen-3-ylpropan-1-one. Molecular Formula: C7H8OS. Molecular Weight: 140.2. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Reporting of adverse drug reactions in randomised controlled trials – a systematic survey

Background
          Decisions on treatment are guided, not only by the potential for benefit, but also by the nature and severity of adverse drug reactions. However, some researchers have found numerous deficiencies in trial reports of adverse effects. We sought to confirm these findings by evaluating trials of drug therapy published in seven eminent medical journals in 1997.
        
        
          Methods
          Literature review to determine whether the definition, recording and reporting of adverse drug reactions in clinical trials were in accordance with published recommendations on structured reporting.
        
        
          Results
          Of the 185 trials reviewed, 25 (14%) made no mention of adverse drug reactions. Data in a further 60 (32%) could not be fully evaluated, either because numbers were not given for each treatment arm (31 trials), or because a generic statement was made without full details (29 trials). When adverse drug reactions such as clinical events or patient symptoms were mentioned in the reports, details on how they had been recorded were given in only 14/95 (15%) and 18/104 (17%) trials respectively. Of the 86 trials that mentioned severity of adverse drug reactions, only 42 (49%) stated how severity had been defined. The median amount of space used for safety data in the Results and Discussion sections was 5.8%.
        
        
          Conclusions
          Trial reports often failed to provide details on how adverse drug reactions were defined or recorded. The absence of such methodological information makes comparative evaluation of adverse reaction rates potentially unreliable. Authors and journals should adopt recommendations on the structured reporting of adverse effects.

Tags: adverse-drug-reactions, clinical-trial-reporting, drug-safety, nih, systematic-review
Organization: U.S. Department of Health & Human Services