AndreaBozzo/ceres-open-data-index huggingface dataset:
2021-2022 NSDUH: Model-Based Estimated Totals for States (in Thousands):

Browse state-level population estimates based on the 2021-2022 National Surveys on Drug Use and Health (NSDUH). The 37 tables include estimates for 35 measures of substance use and mental health, by age group, along with 95% confidence intervals. The estimates are based on small area estimation (SAE) methods, in which state-level NSDUH data are combined with other data from smaller geographies. The combined data are used to create modeled state estimates of the civilian, noninstitutionalized population ages 12 and older, or adults 18 and older for mental health measures. Each table covers a single measure by state, region, and age group.The indicators are presented in the following 37 tables:Drug use and Perceived RiskIllicit Drug Use in the Past MonthMarijuana Use in the Past YearMarijuana Use in the Past MonthPerceptions of Great Risk from Smoking Marijuana Once a MonthFirst Use of Marijuana in the Past Year (among those at risk for initiation)Illicit Drug Use Other than Marijuana in the Past MonthCocaine Use in the Past YearPerceptions of Great Risk from using Cocaine Once a MonthHeroin Use in the Past YearPerceptions of Great Risk from Trying Heroin Once or TwiceHallucinogen Use in the Past YearMethamphetamine Use in the Past YearPrescription Pain Reliever Misuse in the Past YearOpioid Misuse in the Past YearAlcoholAlcohol Use in the Past MonthBinge Alcohol Use in the Past MonthPerceptions of Great Risk from Having Five or More Drinks of an Alcoholic Beverage Once or Twice a WeekAlcohol Use, Binge Alcohol Use in the Past Month, and Perceptions of Great Risk from Having Five or More Drinks of an Alcoholic Beverage Once or Twice a Week (among people aged 12 to 20)TobaccoTobacco Product Use in the Past MonthCigarette Use in the Past MonthPerceptions of Great Risk from Smoking One or More Packs of Cigarettes per DaySubstance Use DisordersSubstance Use Disorder in the Past YearAlcohol Use Disorder in the Past YearAlcohol Use Disorder in the Past Year (among people aged 12 to 20)Drug Use Disorder in the Past YearPain Reliever Use Disorder in the Past YearOpioid Use Disorder in the Past YearSubstance Use TreatmentReceived Substance Use Treatment in the Past YearClassified as Needing Substance Use Treatment in the Past YearDid Not Receive Substance Use Treatment in the Past Year among those Classified as Needing Substance Use TreatmentMental IllnessAny Mental Illness in the Past YearSerious Mental Illness in the Past YearReceived Mental Health Treatment in the Past YearMajor Depressive Episode in the Past YearSuicidalityHad Serious Thoughts of Suicide in the Past YearMade Any Suicide Plans in the Past YearAttempted Suicide in the Past YearThe tables are available in an Excel spreadsheet, a PDF file, or as a zip file of 37 CSV text files.

Tags: mental-health, nsduh-data, samhsa, state-estimates, substance-use
Organization: U.S. Department of Health & Human Services
Human members of the eukaryotic protein kinase family

Publicly available genetic sequence data were searched for human sequences that potentially represent protein kinases, important players in virtually every signaling pathway. After removal of duplicates, splice variants and pseudogenes, this search yielded 510 sequences with recognizable similarity to eukaryotic protein kinases.

Tags: genetic-sequences, human-genome, nih, protein-kinases, signaling-pathways
Organization: U.S. Department of Health & Human Services
4.4 Facility size, according to type of care offered, by facility operation and primary focus of facility: March 31, 2011. Median number of clients

This a National Survey of Substance Abuse Treatment Services (N-SSATS) data table showing facility size, according to type of care offered, by facility operation and primary focus in 2011.

Tags: facility-characteristics, n-ssats, samhsa, substance-abuse-treatment, treatment-capacity
Organization: U.S. Department of Health & Human Services
Reducing Substance Use Among Clients in the Pregnant and Postpartum Women Pilot Program

This CBHSQ Spotlight presents findings from an evaluation of the State Pilot Program for Treatment for Pregnant and Postpartum Women (PPW-PLT). This pilot program was designed to complement the residential PPW program by developing a continuum of family-centered care services in an outpatient setting. This spotlight compares program clients’ self-reported substance use from data collected at the intake and six-month follow up interviews.

Tags: postpartum-substance-use, ppw-pilot-program, pregnant-women, samhsa, substance-use-treatment
Organization: U.S. Department of Health & Human Services
Two pathways act in an additive rather than obligatorily synergistic fashion to induce systemic acquired resistance and

Background
          Local infection with necrotizing pathogens induces whole plant immunity to secondary challenge. Pathogenesis-related genes are induced in parallel with this systemic acquired resistance response and thought to be co-regulated. The hypothesis of co-regulation has been challenged by induction of Arabidopsis PR-1 but not systemic acquired resistance in npr1 mutant plants responding to Pseudomonas syringae carrying the avirulence gene avrRpt2. However, experiments with ndr1 mutant plants have revealed major differences between avirulence genes. The ndr1-1 mutation prevents hypersensitive cell death, systemic acquired resistance and PR-1 induction elicited by bacteria carrying avrRpt2. This mutation does not prevent these responses to bacteria carrying avrB.
        
        
          Results
          Systemic acquired resistance, PR-1 induction and PR-5 induction were assessed in comparisons of npr1-2 and ndr1-1 mutant plants, double mutant plants, and wild-type plants. Systemic acquired resistance was displayed by all four plant lines in response to Pseudomonas syringae bacteria carrying avrB. PR-1 induction was partially impaired by either single mutation in response to either bacterial strain, but only fully impaired in the double mutant in response to avrRpt2. PR-5 induction was not fully impaired in any of the mutants in response to either avirulence gene.
        
        
          Conclusion
          Two pathways act additively, rather than in an obligatorily synergistic fashion, to induce systemic acquired resistance, PR-1 and PR-5. One of these pathways is NPR1-independent and depends on signals associated with hypersensitive cell death. The other pathway is dependent on salicylic acid accumulation and acts through NPR1. At least two other pathways also contribute additively to PR-5 induction.

Tags: nih, npr1-mutant, plant-immunity, pr-1-induction, systemic-acquired-resistance
Organization: U.S. Department of Health & Human Services
'Round-table' ethical debate: is a suicide note an authoritative 'living will'?

Living wills are often considered by physicians who are faced with a dying patient. Although popular with the general public, they remain problems of authenticity and authority. It is difficult for the examining physician to know whether the patient understood the terms of the advance directive when they signed it, and whether they still consider it authoritative at the time that it is produced. Also, there is little consensus on what spectrum of instruments constitutes a binding advance directive in real life. Does a 'suicide note' constitute an authentic and authoritative 'living will'? Our panel of authorities considers this problem in a round-table discussion.

Tags: advance-directives, medical-ethics, nih, suicide-note, suicide-notes
Organization: U.S. Department of Health & Human Services
Phylogenetic analysis of 277 human G-protein-coupled receptors as a tool for the prediction of orphan receptor ligands

G-protein-coupled receptors (GPCRs) are the largest and most diverse family of transmembrane receptors. A pylogenetic analysis shows the overall relationship of 277 human GPCRs. An emphasis on receptors with no identified natural ligand may prove valuable for identification of the ligands of 'orphan' receptors.

Tags: g-protein-coupled-receptors, ligand-prediction, nih, orphan-receptors, phylogenetic-analysis
Organization: U.S. Department of Health & Human Services
Compound 527376: 20,24-Dimethyl-triacontyl cyanide

Chemical compound data from PubChem database. IUPAC Name: 21,25-dimethylhentriacontanenitrile. Molecular Formula: C33H65N. Molecular Weight: 475.9. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
MCM2 - a promising marker for premalignant lesions of the lung: a cohort study

Background
          Because cells progressing to cancer must proliferate, marker proteins specific to proliferating cells may permit detection of premalignant lesions. Here we compared the sensitivities of a classic proliferation marker, Ki-67, with a new proliferation marker, MCM2, in 41 bronchial biopsy specimens representing normal mucosa, metaplasia, dysplasia, and carcinoma in situ.
        
        
          Methods
          Parallel sections were stained with antibodies against MCM2 and Ki-67, and the frequencies of staining were independently measured by two investigators. Differences were evaluated statistically using the two-sided correlated samples t-test and Wilcoxon rank sum test.
        
        
          Results
          For each of the 41 specimens, the average frequency of staining by anti-MCM2 (39%) was significantly (p < 0.001) greater than by anti-Ki-67 (16%). In metaplastic lesions anti-MCM2 frequently detected cells near the epithelial surface, while anti-Ki-67 did not.
        
        
          Conclusions
          We conclude that MCM2 is detectable in 2-3 times more proliferating premalignant lung cells than is Ki-67. The promise of MCM2 as a sensitive marker for premalignant lung cells is enhanced by the fact that it is present in cells at the surface of metaplastic lung lesions, which are more likely to be exfoliated into sputum. Future studies will determine if use of anti-MCM2 makes possible sufficiently early detection to significantly enhance lung cancer survival rates.

Tags: biomarkers, lung-cancer, mcm2-protein, nih, premalignant-lesions
Organization: U.S. Department of Health & Human Services
Child and Family Services Reviews Update: Volume 8, Issue 1, January 2016

This issue of Child and Family Services Reviews Update contains the following sections: 2015 State Reviews, 2016 and 2017 State Reviews, CFSR Procedures Manual: Updates, Onsite Review Instrument and Instructions: Updates, and JBS: CFSR Reviewers and QA/Note-Taking Specialists.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: child, manual, policy, reporting, scope
Organization: U.S. Department of Health & Human Services
Compound 528374: Benzene, 1-methyloctyl

Chemical compound data from PubChem database. IUPAC Name: nonan-2-ylbenzene. Molecular Formula: C15H24. Molecular Weight: 204.35. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Representation of women's health in general medical versus women's health specialty journals: a content analysis

Background
          Women's health, traditionally defined, emphasises reproductive and maternal conditions without consideration of social contexts. Advocates urge a broader conceptualisation. The medical literature influences the definitions and delivery of women's health care. We compared how women's health was represented in leading general medical (GM) versus women's health specialty (WS) journals.
        
        
          Methods
          Original investigations published between January 1 – June 30, 1999 in leading GM (n = 514) and WS (n = 82) journals were compared. Data were collected from 99 GM and 82 WS articles on women's health. Independent reviewers conducted content analyses of sample characteristics, study design, and health topic. Each article was classified as "Traditional" (e.g. menstruation, breast cancer), "Non-traditional" (e.g. abuse, osteoporosis), or "Both."
        
        
          Results
          Of the GM articles, 53 (53.5%) focused solely on a traditional women's health topic; half were reproductive and half female cancers. In contrast, 22 (26.8%) WS articles were traditionally focused. A non-traditional topic was the sole focus of 27 (27.3%) GM articles versus 34 (41.5%) WS articles. One-fifth of GM and one-third of WS articles addressed both. RCTs dominated the GM articles, while 40% of WS articles used qualitative or mixed study designs. Leading sources of women's death and disability were not well covered in either type of journal.
        
        
          Conclusions
          Most GM articles drew on a narrow definition of women's health. WS journals provided more balanced coverage, addressing social concerns in addition to "navel-to-knees" women's health. Since GM journals have wide impact, editorial decisions and peer review processes should promote a broader conceptualisation of women's health.

Tags: content-analysis, health-topics, medical-journals, nih, womens-health-research
Organization: U.S. Department of Health & Human Services
2014 CMHS Uniform Reporting System (URS) Table for Hawaii

2014 Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for Hawaii. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant, hawaii, mental-health-services, noms-measures, samhsa
Organization: U.S. Department of Health & Human Services
Compound 529119: 4-Quinazolone, 3-ethyl-2-pentyl

Chemical compound data from PubChem database. IUPAC Name: 3-ethyl-2-pentylquinazolin-4-one. Molecular Formula: C15H20N2O. Molecular Weight: 244.33. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Annotated Bibliography on Equity in Health, 1980-2001

The purposes of this bibliography are to present an overview of the published literature on equity in health and to summarize key articles relevant to the mission of the International Society for Equity in Health (ISEqH). The intent is to show the directions being taken in health equity research including theories, methods, and interventions to understand the genesis of inequities and their remediation. Therefore, the bibliography includes articles from the health equity literature that focus on mechanisms by which inequities in health arise and approaches to reducing them where and when they exist.

Tags: bibliography, health-equity, health-inequities, nih, social-determinants-health
Organization: U.S. Department of Health & Human Services
NSDUH 2017 Editing and Imputation Report

This report focuses on the editing and statistical imputation procedures that were applied to respondent data for the 2017 NSDUH. Logical editing uses data from elsewhere within the same respondent's record to reduce the occurrence of missing or ambiguous data or to resolve inconsistencies between related variables. Imputation is defined as the replacement of missing values with valid, nonmissing values. Statistical imputation usually involves some randomness to preserve the natural variability in the data.

Tags: data-imputation, missing-data, nsduh-data, samhsa, statistical-editing
Organization: U.S. Department of Health & Human Services
Compound 526200: Methyl 4-methyl-2-[[2-(3-oxo-2-pent-2-enylcyclopentyl)acetyl]amino]pentanoate

Chemical compound data from PubChem database. IUPAC Name: methyl 4-methyl-2-[[2-(3-oxo-2-pent-2-enylcyclopentyl)acetyl]amino]pentanoate. Molecular Formula: C19H31NO4. Molecular Weight: 337.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2016-2018 Substate Estimates of Substance Use and Mental Illness

Substate estimates for 15 measures of substance use and mental illness based on the combined 2016, 2017, and 2018 National Surveys on Drug Use and Health (NSDUHs) are provided. NSDUH is an ongoing survey of the civilian, noninstitutionalized population of the United States aged 12 years or older. Estimates presented here are based on a small area estimation (SAE) methodology in which substate-level NSDUH data are combined with county and census block group/tract-level data from the state.

Tags: mental-illness, nsduh-data, samhsa, small-area-estimation, substance-use
Organization: U.S. Department of Health & Human Services
Biochemical, electron microscopic and immunohistological observations of cationic detergent-extracted cells: detection and improved preservation of microextensions and ultramicroextensions

Background
          Filopodia, retraction fibers and microvilli, are fragile microextensions of the plasma membrane that are easily damaged by mechanical force during specimen preparation for microscopy. To preserve these structures for electron microscopy glutaraldehyde is generally used, but it often causes antigen masking. By contrast, formaldehyde is generally used for immunofluorescence light microscopy, but few studies have been concerned with the loss of microextensions.
        
        
          Results
          We demonstrate in biochemical experiments that cultured cells needed to be kept in 4% formaldehyde for at least 60 min at room temperature or for 20 min at 37°C to irreversibly crosslink most of the polypeptides. Also, fragmentation of fragile microextensions was observed after Triton X-100 extraction depending on concentration and extent of crosslinking. We also report on a novel fixation procedure that includes the cationic detergent dodecyltrimethylammonium chloride (DOTMAC). Treatment of NIH3T3 cells with DOTMAC resulted in complete removal of membrane lipids and in good preservation of the cytoskeleton in microextensions as well as preservation of ultramicroextensions of <0.05μm in diameter that have not been observed previously unless glutaraldehyde was used. Stress fibers and microextensions of DOTMAC-extracted cells were readily stained with anti-β-actin antibodies, and antibodies to vinculin and moesin stained focal contacts and microextensions, respectively.
        
        
          Conclusions
          Some microextensions were fragmented by the standard Triton X-100 permeabilization method. By contrast, DOTMAC completely extracted membrane lipids while maintaining the cytoskeleton of microextensions. Thus, DOTMAC treatment may provide a valuable new tool for the reliable visualization of previously undetectable or poorly detectable antigens while preserving the actin cytoskeleton of microextensions.

Tags: cell-fixation, cell-microextensions, electron-microscopy, immunohistology, nih
Organization: U.S. Department of Health & Human Services
Compound 528678: 1-Methyl-3-n-Pentylbenzene

Chemical compound data from PubChem database. IUPAC Name: 1-methyl-3-pentylbenzene. Molecular Formula: C12H18. Molecular Weight: 162.27. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 527422: (1,7,7-Trimethyl-2-bicyclo[2.2.1]heptanyl) 2-methylbut-2-enoate

Chemical compound data from PubChem database. IUPAC Name: (1,7,7-trimethyl-2-bicyclo[2.2.1]heptanyl) 2-methylbut-2-enoate. Molecular Formula: C15H24O2. Molecular Weight: 236.35. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 528007: 2-Propynyl 3,5-dinitrobenzoate

Chemical compound data from PubChem database. IUPAC Name: prop-2-ynyl 3,5-dinitrobenzoate. Molecular Formula: C10H6N2O6. Molecular Weight: 250.16. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 526829: 13-Hydroxy-stearic acid, methyl ester, tBDMS ether

Chemical compound data from PubChem database. IUPAC Name: methyl 13-[tert-butyl(dimethyl)silyl]oxyoctadecanoate. Molecular Formula: C25H52O3Si. Molecular Weight: 428.8. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 525135: Butyl n-heptyl phthalate

Chemical compound data from PubChem database. IUPAC Name: 1-O-butyl 2-O-heptyl benzene-1,2-dicarboxylate. Molecular Formula: C19H28O4. Molecular Weight: 320.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
The Metal Coordination of sCD39 during ATP Hydrolysis

Background
          The hydrolysis of ATP and ADP by ecto-nucleoside triphosphate diphosphohydrolase 1 (CD39) requires divalent cations, like Ca2+ and Mg2+. In spite of considerable work, it is not clear whether divalent cations bind to the enzyme in the absence of nucleotide or only as nucleotide-Me+2 complex. Here we study the protein ligands for Me+2.
        
        
          Results
          When VO2+ was used as a substitute for Ca2+, the ATPase activity of soluble CD39 was 25% of that with Ca2+ as cofactor. Protein ligands of the VO2+-nucleotide complex bound to the catalytic site of soluble CD39 were characterized by electron paramagnetic resonance (EPR) spectroscopy. The EPR spectrum contained one species designated T with VO2+-AMPPNP as ligand. Two species D1 and D2 were observed when VO2+-AMPCP was bound to soluble CD39. The results suggest that species D1 and D2 represent the metal-ADP complexes at the catalytic site of soluble CD39 corresponding to the intermediate formed during ATP hydrolysis and the substrate for further hydrolysis, respectively.
        
        
          Conclusions
          VO2+ can functionally substitute for Ca2+ as a cofactor of sCD39, and it produces four different EPR features when bound in the presence of different nucleotides or in the absence of nucleotide. The metal coordination for each conformation corresponding to each EPR species is proposed, and the mechanism of sCD39 catalysis is discussed.

Tags: atp-hydrolysis, cd39-enzyme, ecto-nucleoside-triphosphate, metal-coordination, nih
Organization: U.S. Department of Health & Human Services