AndreaBozzo/ceres-open-data-index huggingface dataset:
Exertional dyspnea as initial manifestation of Takayasu's arteritis – A case report and literature review

Background
          Takayasu's arteritis is a chronic systemic inflammatory disease that usually affects the aorta, its primary branches and occasionally the pulmonary and coronary arteries. Female gender in reproductive age and Asian origin are known factors associated with higher disease prevalence. The clinical manifestations vary considerably and are typically caused by limb or organ ischemia illness and fever. The estimated incidence rate in the western world is 2.6 cases per million persons per year. Occasionally, exertional dyspnea can be the sole primary clinical manifestation of Takayasu's arteritis.
        
        
          Case presentation
          We report the case of a 57-year-old woman who was referred to our institution with increasing exertional dyspnea caused by pulmonary artery involvement in Takayasu's arteritis. In a review of the literature we discuss demographic data, clinical and radiographic findings and available therapeutic options.
        
        
          Conclusions
          Dyspnea due to pulmonary artery involvement can be the initial symptom of Takayasu's arteritis. Simple clinical tests, including a complete pulse-status and blood pressure measuring at both arms can lead to the right diagnosis and should always be done beyond the auscultation of the heart and lungs in patients with dyspnea.

Tags: case-report, exertional-dyspnea, nih, pulmonary-artery, takayasu-arteritis
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Texas, 2013

This is a behavioral health report for the state of Texas. It uses the  National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment Services (NSSATS) to address the topics of youth substance use , youth mental health and treatment, adult mental health and treatment, substance use, substance use treatment for the years 2008 to 2012.

Tags: mental-health-texas, samhsa, substance-use-trends, texas-behavioral-health, youth-mental-health
Organization: U.S. Department of Health & Human Services
Incidence and Characteristics of Total Stroke in the United States

Background and Purpose
          Stroke, increasingly referred to as a "brain attack", is one of the leading causes of death and the leading cause of adult disability in the United States. It has recently been estimated that there were three quarters of a million strokes in the United States in 1995. The aim of this study was to replicate the 1995 estimate and examine if there was an increase from 1995 to 1996 by using a large administrative claims database representative of all 1996 US inpatient discharges.
        
        
          Methods
          We used the Nationwide Inpatient Sample of the Healthcare Cost and Utilization Project, release 5, which contains ≈ 20 percent of all 1996 US inpatient discharges. We identified stroke patients by using the International Classification of Diseases, 9th Revision, Clinical Modification (ICD-9-CM) codes from 430 to 438, and we compared the 1996 database with that of 1995.
        
        
          Results
          There were 712,000 occurrences of stroke with hospitalization (95% CI 688,000 to 737,000) and an estimated 71,000 occurrences of stroke without hospitalization. This totaled 783,000 occurrences of stroke in 1996, compared to 750,000 in 1995. The overall rate for occurrence of total stroke (first-ever and recurrent) was 269 per 100,000 population (age- and sex-adjusted to 1996 US population).
        
        
          Conclusions
          We estimate that there were 783,000 first-ever or recurrent strokes in the United States during 1996,
compared to the figure of 750,000 in 1995. This study replicates and confirms the previous annual estimates of 
approximately three quarters of a million total strokes. This slight increase is likely due to the aging of the population and
the population gain in the US from 1995 to 1996.

Tags: brain-attack, icd-9-stroke, inpatient-stroke, nih, stroke-incidence
Organization: U.S. Department of Health & Human Services
Gene expression profiles derived from fine needle aspiration correlate with response to systemic chemotherapy in breast cancer

Background
          Drug resistance in breast cancer is a major obstacle to successful chemotherapy. In this study we used cDNA microarray technology to examine gene expression profiles obtained from fine needle aspiration (FNA) of primary breast tumors before and after systemic chemotherapy. Our goal was to determine the feasibility of obtaining representative expression array profiles from limited amounts of tissue and to identify those expression profiles that correlate with treatment response.
        
        
          Methods
          Repeat presurgical FNA samples were taken from six patients who were to undergo primary surgical treatment. Additionally, a group of 10 patients who were to receive neoadjuvant chemotherapy underwent two FNAs before chemotherapy (adriamycin 60 mg/m2 and cyclophosphamide 600 mg/m2) followed by another FNA on day 21 after the first cycle. Total RNA was amplified with T7 Eberwine's procedure and labeled cDNA was hybridized onto a 7600-feature glass cDNA microarray.
        
        
          Results
          We identified candidate gene expression profiles that might distinguish tumors with complete response to chemotherapy from tumors that do not respond, and found that the number of genes that change after one cycle of chemotherapy was 10 times greater in the responding group than in the non-responding group.
        
        
          Conclusion
          This study supports the suitability of FNA-derived cDNA microarray expression profiling of breast cancers as a comprehensive genomic approach for studying the mechanisms of drug resistance. Our findings also demonstrate the potential of monitoring post-chemotherapy changes in expression profiles as a measure of pharmacodynamic effect and suggests that these approaches might yield useful results when validated by larger studies.

Tags: breast-cancer, chemotherapy-response, fine-needle-aspiration, gene-expression, nih
Organization: U.S. Department of Health & Human Services
NSDUH 2018 Sample Experience Report

The goal of this report is to further document the 2018 NSDUH sample experiences, including a comparison of actual sample yields to state and quarter targets, a comparison of achieved and expected design effects (DEFFs) and relative standard errors, and documentation of any issue encountered during sample implementation. The 2018 sample design is thoroughly documented in the 2018 NSDUH sample design report (Center for Behavioral Health Statistics and Quality, 2019a).

Tags: design-effects, nsduh, samhsa, sample-design, survey-methodology
Organization: U.S. Department of Health & Human Services
Compound 527330: Tiaprofenic Acid Methyl Ester

Chemical compound data from PubChem database. IUPAC Name: methyl 2-(5-benzoylthiophen-2-yl)propanoate. Molecular Formula: C15H14O3S. Molecular Weight: 274.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: West Virginia, 2014

This is a behavioral health report for the state of West Virginia. It uses the  National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment Services (NSSATS) to address the topics of youth substance use , youth mental health and treatment, adult mental health and treatment, substance use, substance use treatment, and medicare enrollees for the years 2009 to 2013.

Tags: behavioral-health, mental-health, samhsa, substance-use, west-virginia
Organization: U.S. Department of Health & Human Services
Compound 525590: N,N-Dimethyl-N'-(4-chlorophenyl)-benzamidine

Chemical compound data from PubChem database. IUPAC Name: N'-(4-chlorophenyl)-N,N-dimethylbenzenecarboximidamide. Molecular Formula: C15H15ClN2. Molecular Weight: 258.74. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Serum organochlorines and urinary porphyrin pattern in a population highly exposed to hexachlorobenzene

Background
          Porphyria cutanea tarda (PCT) is caused by hexachlorobenzene (HCB) in several species of laboratory mammals, but the human evidence is contradictory. In a study among adults of a population highly exposed to HCB (Flix, Catalonia, Spain), the prevalence of PCT was not increased. We aimed at analysing the association of individual urinary porphyrins with the serum concentrations of HCB and other organochlorine compounds in this highly exposed population.
        
        
          Methods
          A cross-sectional study on total porphyrins was carried out in 1994 on 604 inhabitants of the general population of Flix, older than 14 years. Of them, 241 subjects (comprising a random sample and the subgroup with the highest exposure) were included for the present study. The porphyrin profile was determined by high-pressure liquid chromatography. Serum concentrations of HCB, as well as common organochlorine compounds, were determined by gas chromatography coupled to electron capture detection.
        
        
          Results
          Coproporphyrin I (CPI) and coproporphyrin III (CPIII) were the major porphyrins excreted, while uroporphyrins I and III were only detected in 2% and 36% of the subjects respectively, and heptaporphyrins I and III in 1% and 6%, respectively. CPI and CPIII decreased with increasing HCB concentrations (p < 0.05). This negative association was not explained by age, alcohol, smoking, or other organochlorine compounds. No association was found between uroporphyrin I and III excretion, nor heptaporphyrin excretion, and HCB. CPIII increased with smoking (p < 0.05).
        
        
          Conclusion
          HCB exposure in this highly exposed population did not increase urinary concentrations of individual porphyrins.

Tags: hexachlorobenzene-exposure, nih, organochlorine-compounds, porphyria-cutanea-tarda, urinary-porphyrins
Organization: U.S. Department of Health & Human Services
Experience collecting interim data on mortality: an example from the RALES study

Introduction
          The Randomized Aldactone Evaluation Study (RALES) randomized 822 patients to receive 25 mg spironolactone daily and 841 to receive placebo. The primary endpoint was death from all causes. Randomization began on March 24, 1995; recruitment was completed on December 31, 1996; follow-up was scheduled to continue through December 31, 1999. Evidence of a sizeable benefit on mortality emerged early in the RALES. The RALES data safety monitoring board (DSMB), which met semiannually throughout the trial, used a prespecified statistical guideline to recommend stopping for efficacy. At the DSMB's request, its meetings were preceded by an 'endpoint sweep', that is, a census of all participants to confirm their vital status.
        
        
          Methods
          We used computer simulation to evaluate the effect of the sweeps.
        
        
          Results
          The sweeps led to an estimated 5 to 8% increase in the number of reported deaths at the fourth and fifth interim analyses. The data crossed the statistical boundary at the fifth interim analysis. If investigators had reported all deaths within the protocol-required 24-h window, the DSMB might have recommended stopping after the fourth interim analysis.
        
        
          Discussion
          Although endpoint sweeps can cause practical problems at the clinical centers, sweeps are very useful if the intervals between patient visits or contact are long or if endpoints require adjudication by committee, reading center, or central laboratory.
        
        
          Conclusion
          We recommend that trials with interim analyses institute active reporting of the primary endpoints and endpoint sweeps.

Tags: clinical-trial, mortality-reduction, nih, rales-study, spironolactone
Organization: U.S. Department of Health & Human Services
Incomplete gastric metaplasia in children with insulin-dependent diabetes mellitus and celiac disease. An ultrastructural study

Background
          The association of insulin-dependent diabetes mellitus (IDDM) and celiac disease (CD) has been widely reported in children but the relationship between the two conditions is incompletely understood. Moreover, specific studies on intestinal biopsies of patients with the association of the two diseases are still lacking.
        
        
          Methods
          We studied the ultrastructure of the duodenal mucosa in 12 patients with both IDDM and CD.
        
        
          Results
          All patients had either total or partial atrophy of duodenal mucosa. In seven subjects, an accumulation of electrondense granules in the apical cytoplasm of groups of enterocytes was found. In four of them, a double population of granules existed (mean diameter: 400-800 nm and 100-200 nm respectively) showing a biphasic pattern. In the other three patients, only smaller granules (100- 200 nm) were found in the enterocytes.
        
        
          Conclusions
          The present work suggests that patients with IDDM/CD may represent a subgroup in the context of the CD population. Intestinal biopsies of such individuals often show accumulation of electrondense granules in the apical cytoplasm of enterocytes that can be interpreted as incomplete gastric metaplasia.

Tags: duodenal-mucosa, electron-microscopy, gastric-metaplasia, iddm-celiac, nih
Organization: U.S. Department of Health & Human Services
Disruption of spinal cord white matter and sciatic nerve geometry inhibits axonal growth

Background
          Axons within the mature mammalian central nervous system fail to regenerate following injury, usually resulting in long-lasting motor and sensory deficits. Studies involving transplantation of adult neurons into white matter implicate glial scar-associated factors in regeneration failure. However, these studies cannot distinguish between the effects of these factors and disruption of the spatial organization of cells and molecular factors (disrupted geometry). Since white matter can support or inhibit neurite growth depending on the geometry of the fiber tract, the present study sought to determine whether disrupted geometry is sufficient to inhibit neurite growth.
        
        
          Results
          Embryonic chick sympathetic neurons were cultured on unfixed longitudinal cryostat sections of mature rat spinal cord or sciatic nerve that had been crushed with forceps ex vivo then immediately frozen to prevent glial scarring. Neurite growth on uncrushed portions of spinal cord white matter or sciatic nerve was extensive and highly parallel with the longitudinal axis of the fiber tract but did not extend onto crushed portions. Moreover, neurite growth from neurons attached directly to crushed white matter or nerve tissue was shorter and less parallel compared with neurite growth on uncrushed tissue. In contrast, neurite growth appeared to be unaffected by crushed spinal cord gray matter.
        
        
          Conclusions
          These observations suggest that glial scar-associated factors are not necessary to block axonal growth at sites of injury. Disruption of fiber tract geometry, perhaps involving myelin-associated neurite-growth inhibitors, may be sufficient to pose a barrier to regenerating axons in spinal cord white matter and peripheral nerves.

Tags: axonal-regeneration, neurite-growth, nih, sciatic-nerve, spinal-cord-injury
Organization: U.S. Department of Health & Human Services
Table 16. Perceptions of Great Risk of Smoking One or More Packs of Cigarettes Per Day among Persons Aged 12 or Older, by State and Substate Regions: Percentages, Annual Averages Based on 2008, 2009, and 2010 NSDUHs

This table presents the 2008 to 2010 National Survey on Drug Use and Health (NSDUH) estimates of perceptions of great risk of having smoking one or more packs of cigarettes a day among those aged 12 or older by State and substate regions.

Tags: adolescent-health, cigarette-use, nsduh, samhsa, smoking-risk-perception
Organization: U.S. Department of Health & Human Services
Compound 525424: 3-(Methylsulfanyl)prop-1-yne

Chemical compound data from PubChem database. IUPAC Name: 3-methylsulfanylprop-1-yne. Molecular Formula: C4H6S. Molecular Weight: 86.16. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Immune ablation and stem-cell therapy in autoimmune disease: Clinical experience

In the past 5 years, around 350 patients have received haematopoietic stem cell (HSC) transplantation for an autoimmune disease, with 275 of these registered in an international data base in Basel under the auspices of the European League Against Rheumatism (EULAR) and the European Group for Blood and Marrow Transplantation(EBMT). Most patients had either a progressive form of multiple sclerosis (MS; n = 88) or scleroderma (now called systemic sclerosis; n = 55). Other diseases were rheumatoid arthritis (Ra n = 40), juvenile idiopathic arthritis (JIA; n = 30), systemic lupus erythematosus (SLE; n = 20), idiopathic thrombocytopenic purpura (ITP; n = 7) and others. The procedure-related mortality was around 9%, with between-disease differences, being higher in systemic sclerosis and JIA and lower in RA (one death only). Benefit has been seen in around two-thirds of cases. No one regimen was clearly superior to another, with a trend toward more infectious complications with more intense regimens. Prospective, controlled randomized trials are indicated and being planned.

Tags: autoimmune-diseases, hematopoietic-stem-cell, nih, stem-cell-transplantation, treatment-outcomes
Organization: U.S. Department of Health & Human Services
Compound 528451: 1-Hexadecene, 6-ethyl

Chemical compound data from PubChem database. IUPAC Name: 6-ethylhexadec-1-ene. Molecular Formula: C18H36. Molecular Weight: 252.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Alaska (AK)

This report uses 2008 to 2010 National Survey on Drug Use and Health (NSDUH) to assess past year alcohol use disorder and illicit drug use disorder among persons aged 12 or older for Alaska overall and for substate regions within Alaska. Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE).

Tags: alcohol-use-disorder, mental-health-alaska, nsduh-data, samhsa, substance-use-disorder
Organization: U.S. Department of Health & Human Services
Compound 525349: 2,2-Dimethyl-3,4-dithiaheptane

Chemical compound data from PubChem database. IUPAC Name: 2-methyl-2-(propyldisulfanyl)propane. Molecular Formula: C7H16S2. Molecular Weight: 164.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2010 State Profile — Maryland

This state profile includes data from facilities in Maryland that reported to N-SSATS for the survey reference date March 31, 2010. Data were collected on the location, characteristics, services offered, and number of clients in treatment at alcohol and drug abuse treatment facilities (both public and private) in Maryland. In Maryland, 339 substance abuse treatment facilities were included in the 2010 N-SSATS, reporting that there were 38,770 clients in substance abuse treatment on March 31, 2010. The survey response rate in Maryland was 95.2%.

Tags: addiction-services, maryland, n-ssats, samhsa, substance-abuse-treatment
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Arkansas, 2013

This is a behavioral health report for the state of Arkansas. It uses the  National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment Services (NSSATS) to address the topics of youth substance use , youth mental health and treatment, adult mental health and treatment, substance use, and substance use treatment  for the years 2008 to 2012.

Tags: arkansas-behavioral-health, mental-health-arkansas, samhsa, substance-use-arkansas, youth-behavioral-health
Organization: U.S. Department of Health & Human Services
Program Instruction for the June 30, 2023 State submission of: (1) the fourth Annual Progress and Services Report (APSR); (2) the Child Abuse Prevention and Treatment Act (CAPTA) State Plan update; and (3) the CFS-101s

This Program Instruction (PI) provides guidance to states, territories, and insular areas (hereafter “states,” unless otherwise noted) on actions they are required to take to receive their allotments for Federal Fiscal Year (FY)1 2024 (subject to the availability of appropriations) authorized under title IV-B, subparts 1 and 2, section 106 of CAPTA, Chafee and ETV programs.

PI-23-01 (PDF)

CFS-101 Instructions, Part I, II, and III

Introduction
Part I: Annual Budget Request for Title IV-B, Subpart 1 & 2 Funds, CAPTA, Chafee, and ETV Instructions
Part II: Annual Estimated Expenditure Summary of Child and Family Services Instructions 
Part III: Expenditures for Title IV-B, Subparts 1 and 2, Chafee Foster Care Program for Successful Transition to Adulthood (Chafee) and Education and Training Voucher (ETV) Programs Instructions

CFS-101 Forms, Parts I, II and III Excel Workbook (XLSX) (Updated as of 3/24/2023)

CFS-101 Forms Part I
CFS-101 Forms Part II
CFS-101 Forms Part III

Annual Reporting of Education and Training Vouchers Awarded (PDF)

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: abuse, compliance, fiscal, prevention, reporting
Organization: U.S. Department of Health & Human Services