AndreaBozzo/ceres-open-data-index huggingface dataset:
Role of free radicals in the pathogenesis of acute chest syndrome in sickle cell disease

Acute chest syndrome (ACS) of sickle cell disease (SCD) is characterized pathologically by vaso-occlusive processes that result from abnormal interactions between sickle red blood cells (RBCs), white blood cells (WBCs) and/or platelets, and the vascular endothelium. One potential mechanism of vascular damage in ACS is by generation of oxygen-related molecules, such as superoxide (O2-), hydrogen peroxide (H2O2), peroxynitrite (ONOO-), and the hydroxyl (•OH) radical. The present review summarizes the evidence for alterations in oxidant stress during ACS of SCD, and the potential contributions of RBCs, WBCs and the vascular endothelium to this process.

Tags: acute-chest-syndrome, free-radicals, nih, oxidative-stress, sickle-cell-disease
Organization: U.S. Department of Health & Human Services
New Mexico (NM)

This report presents New Mexico\'s estimates for 25 measures of substance use and mental health based on the combined 2009 and 2010 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for New Mexico for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: mental-health, new-mexico, samhsa, substance-use, survey-data
Organization: U.S. Department of Health & Human Services
HHS Unaccompanied Children Program

This data represents unaccompanied children who are taken into custody by Customs and Border Protection brought to a facility and processed for transfer to the Department of Health and Human Services (HHS) as required by law. HHS holds the child for testing and quarantine, and shelters the child until the child is placed with a sponsor here in the United States.

<b>Units of Response: </b>Unaccompanied Children in HHS Care

<b>Type of Data: </b>Administrative

<b>Tribal Data: </b>No

<b>Periodicity: </b>Annual and Monthly

<b>SORN: </b>Not Applicable

<b>Data Use Agreement: </b>Unavailable

<b>Data Use Agreement Location: </b>Not Applicable

<b>Granularity: </b>County;State

<b>Spatial: </b>United States

<b>Geocoding: </b>County;State

Tags: unaccompanied-children
Organization: U.S. Department of Health & Human Services
The First National Juvenile Online Victimization Incidence Study (N-JOV-1)

Eighty-eight percent of the agencies (n = 2,270) that received mail surveys responded.  Seventeen percent of the agencies (n = 383) that responded reported 1,723 arrests.  Interviews were conducted on all eligible cases that had identified victims or came from agencies reporting three or fewer cases.  When agencies reported four or more cases, a random sample of cases was selected for interviews.  A total of 612 unique interviews were completed.  Data was weighted to estimate annual numbers of arrests.  The procedure took into account sampling procedures and non-response, allowing use of the data to project estimated annual arrest totals with 95% confidence that the accurate number would fall within a specific range.

Investigators: David Finkelhor, Ph.D.
University of New Hampshire Durham, NH

Janis Wolak, J.D.
University of New Hampshire Durham, NH

Kimberly J. Mitchell, Ph.D.
University of New Hampshire Durham, NH

Tags: abuse, care, ndacan, policy, reporting
Organization: U.S. Department of Health & Human Services
Large scale sex typing of ostriches using DNA extracted from feathers

Background
          Ostrich (Struthio camelus) breeds have been gaining increasing significance around the world. The large-scale sex determination of chicks is an important task in the development of these breeds. To date, two PCR-based methods have been established for ostrich sex typing, neither of them intended for large-scale analyses. Here, we report on a protocol adapted to carry out large-scale gender scoring using DNA obtained from chick feathers.
        
        
          Results
          The DNA was extracted using a fast and simple alkaline extraction protocol that provided sufficient template for an early diagnosis. Tests with several primer sets enabled us to determine the best internal control primers associated with the sex-specific primers, avoiding spurious bands. Using DNA extracted from a single bulb and the best set of primers, we applied this protocol to simultaneously sex-type 96 individuals accurately.
        
        
          Conclusion
          We have established a fast, safe, accurate and inexpensive procedure for large-scale sex typing of ostriches using DNA extracted from feathers. This procedure is useful for the gender identification of chicks in the first days of nestling life.

Tags: dna-extraction, feather-dna, nih, ostrich-sex-typing, pcr-analysis
Organization: U.S. Department of Health & Human Services
2011 State Profile — Pennsylvania

This is a National Survey of Substance Abuse Treatment Services (N-SSATS) data table showing state profiles for Pennsylvania in 2011. N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 States, the District of Columbia, and other U.S. jurisdictions.

Tags: n-ssats, pennsylvania, samhsa, substance-abuse-treatment, treatment-facilities
Organization: U.S. Department of Health & Human Services
Compound 525161: Ethyl decyl phthalate

Chemical compound data from PubChem database. IUPAC Name: 1-O-ethyl 2-O-octyl benzene-1,2-dicarboxylate. Molecular Formula: C18H26O4. Molecular Weight: 306.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Right and left prefrontal transcranial magnetic stimulation at 1 Hz does not affect mood in healthy volunteers

Background
          Prefrontal repetitive transcranial magnetic stimulation (rTMS) has been used to induce side-specific mood changes in volunteers and patients. To clarify inconsistencies between reports that used different stimulation frequencies, we conducted a controlled study with a low (1 Hz) frequency, comparing left with right-sided stimulation
        
        
          Methods
          Nineteen healthy volunteers received randomised left or right prefrontal rTMS at a frequency of 1 Hz and 100% of motor threshold in two sessions two weeks apart.
        
        
          Results
          There were significant improvements with TMS for performance in the digit symbol substitution and verbal fluency tests, but no change of mood on a number of measures. There was also a reduction of pulse rate after TMS. The only side-specific TMS-effect was on mean arterial pressure, which decreased pressure after left, but not after right prefrontal TMS.
        
        
          Conclusions
          Apart from the unexpected and so far unreplicated effect on mean arterial pressure, there were no side-specific effects on mood in volunteers. It is unlikely that a simple laterality model of mood together with the assumed activating effect of higher and 'quenching' effect of lower stimulation frequency can account for the effects of TMS on mood.

Tags: healthy-volunteers, mood-regulation, nih, prefrontal-cortex, transcranial-magnetic-stimulation
Organization: U.S. Department of Health & Human Services
Human rights in the biotechnology era 1

Backgound
          The concept of Human Rights has become the modern civilising standard to which all should aspire and indeed attain.
        
        
          Discussion
          In an era characterised by widening disparities in health and human rights across the world and spectacular advances in biotechnology it is necessary to reflect on the extent to which human rights considerations are selectively applied for the benefit of the most privileged people. Attention is drawn particularly to sub-Saharan Africa as a marginalised region at risk of further marginalisation if the power associated with the new biotechnology is not used more wisely than power has been used in the past. To rectify such deficiencies it is proposed that the moral agenda should be broadened and at the very least the concept of rights should be more closely integrated with duties
        
        
          Summary
          New forms of power being unleashed by biotechnology will have to be harnessed and used with greater wisdom than power has been used in the past. Widening disparities in the world are unlikely to be diminished merely by appealing to human rights. We recommend that a deeper understanding is required of the underlying causes of such disparities and that the moral discourse should be extended beyond human rights language.

Tags: biotechnology-ethics, global-health-equity, human-rights, nih, sub-saharan-africa
Organization: U.S. Department of Health & Human Services
2022 Uniform Reporting System (URS) Table For Idaho

This is the 2022 Uniform Reporting System (URS) Output Tables for Idaho. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, evidence-based-practices, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
The viral transmembrane superfamily: possible divergence of Arenavirus and Filovirus glycoproteins from a common RNA virus ancestor

Background
          Recent studies of viral entry proteins from influenza, measles, human immunodeficiency virus, type 1 (HIV-1), and Ebola virus have shown, first with molecular modeling, and then X-ray crystallographic or other biophysical studies, that these disparate viruses share a coiled-coil type of entry protein.
        
        
          Results
          Structural models of the transmembrane glycoproteins (GP-2) of the Arenaviruses, lymphochoriomeningitis virus (LCMV) and Lassa fever virus, are presented, based on consistent structural propensities despite variation in the amino acid sequence. The principal features of the model, a hydrophobic amino terminus, and two antiparallel helices separated by a glycosylated, antigenic apex, are common to a number of otherwise disparate families of enveloped RNA viruses. Within the first amphipathic helix, demonstrable by circular dichroism of a peptide fragment, there is a highly conserved heptad repeat pattern proposed to mediate multimerization by coiled-coil interactions. The amino terminal 18 amino acids are 28% identical and 50% highly similar to the corresponding region of Ebola, a member of the Filovirus family. Within the second, charged helix just prior to membrane insertion there is also high similarity over the central 18 amino acids in corresponding regions of Lassa and Ebola, which may be further related to the similar region of HIV-1 defining a potent antiviral peptide analogue.
        
        
          Conclusions
          These findings indicate a common pattern of structure and function among viral transmembrane fusion proteins from a number of virus families. Such a pattern may define a viral transmembrane superfamily that evolved from a common precursor eons ago.

Tags: arenavirus-glycoprotein, filovirus-glycoprotein, nih, rna-virus-evolution, viral-entry-proteins
Organization: U.S. Department of Health & Human Services
Compound 528546: Hexadecane, 8-octyl

Chemical compound data from PubChem database. IUPAC Name: 9-heptylheptadecane. Molecular Formula: C24H50. Molecular Weight: 338.7. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Problems in dealing with missing data and informative censoring in clinical trials

A common problem in clinical trials is the missing data that occurs when patients do not complete the study and drop out without further measurements. Missing data cause the usual statistical analysis of complete or all available data to be subject to bias. There are no universally applicable methods for handling missing data. We recommend the following: (1) Report reasons for dropouts and proportions for each treatment group; (2) Conduct sensitivity analyses to encompass different scenarios of assumptions and discuss consistency or discrepancy among them; (3) Pay attention to minimize the chance of dropouts at the design stage and during trial monitoring; (4) Collect post-dropout data on the primary endpoints, if at all possible; and (5) Consider the dropout event itself an important endpoint in studies with many.

Tags: clinical-trials, data-censoring, dropout-analysis, missing-data, nih
Organization: U.S. Department of Health & Human Services
2012 Uniform Reporting System (URS) Tables for Maryland

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2012. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, national-outcome-measures, samhsa, urs-data
Organization: U.S. Department of Health & Human Services
2018 NSDUH Annual National Report

Read key findings from the 2018 National Survey on Drug Use and Health (NSDUH) on substance use, mental health, and treatment by age group. Metrics in the report cover the civilian, noninstitutionalized US population ages 12 and older. The report covers both current conditions and trends over time.

Tags: behavioral-health, mental-health, samhsa, substance-use, treatment-outcomes
Organization: U.S. Department of Health & Human Services
Compound 525666: p-Bromobenzylidene-butyl-amine

Chemical compound data from PubChem database. IUPAC Name: 1-(4-bromophenyl)-N-butylmethanimine. Molecular Formula: C11H14BrN. Molecular Weight: 240.14. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
5.3 Clients in treatment, according to substance abuse problem and diagnosed co-occurring mental disorders, by facility operation and primary focus of facility: March 31, 2011. Number and percent

This is a National Survey of Substance Abuse Treatment Services (N-SSATS) data table showing clients in treatment, according to substance abuse problem and diagnosed co-occurring mental disorders, by facility operation and primary focus of facility in 2011. N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 States, the District of Columbia, and other U.S. jurisdictions.

Tags: co-occurring-disorders, mental-health, n-ssats, samhsa, substance-abuse-treatment
Organization: U.S. Department of Health & Human Services
NSDUH 2020 Field Interviewer Manual

This detailed manual was used as a training guide for the Field Interviewers (FIs) who conducted the in-person 2020 National Survey on Drug Use and Health (NSDUH). It covers the information presented at the intensive training for new FIs. Although it is written for NSDUH FIs, researchers may find it helpful for learning about data collection challenges that could affect data quality. It also may be helpful for those designing their own field operations.The manual includes:An introduction to the survey;A guide to what is expected of FIs;Copies of materials that were mailed or given to respondents;FI instructions for locating sample dwelling units, contacting residents, obtaining participation, conducting the screening and interview, documenting their experiences; andQuality control and administrative procedures for FIs.

Tags: data-collection, mental-health, samhsa, substance-use, survey-methodology
Organization: U.S. Department of Health & Human Services
Compound 527254: 5,7,10-Trimethylundec-9-ene-4,6-dione

Chemical compound data from PubChem database. IUPAC Name: 5,7,10-trimethylundec-9-ene-4,6-dione. Molecular Formula: C14H24O2. Molecular Weight: 224.34. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Child Maltreatment Recurrences Among Families Served by Child Protective Services, 1984 to 1992

This longitudinal study of 1,206 families assembled during a 4-year NCCAN-funded research project focuses on recurrences of child maltreatment among families known to public Child Protective Services (CPS). Objectives are to (1) describe recurrence of types, severity, rates, distributions, and frequency of maltreatment over five years; (2) replicate and extend knowledge about predicting recurrence risk after an index incident; (3) initiate development of models to predict recurrence risk after termination of CPS services; and (4) determine (a) whether variables that discriminate between maltreating and non-maltreating families are correlates of recurrent maltreatment and (b) whether hypotheses from models formulated to explain why some parents maltreat also explain recurrences. Products will include risk assessment models.

Investigators: DePanfilis, Diane

Tags: abuse, care, ndacan, policy, reporting
Organization: U.S. Department of Health & Human Services
Young Marijuana Users Often Get Marijuana for Free from Friends (2006 to 2010 NSDUH)

This report uses 2006 to 2010 National Survey on Drug Use and Health (NSDUH) to assess the source of most recently used marijuana among youth aged 12 to 14 who are past year marijuana users.

Tags: drug-source, marijuana-use, nsduh, samhsa, youth-substance-use
Organization: U.S. Department of Health & Human Services
Cellular cardiomyoplasty with autologous skeletal myoblasts for ischemic heart disease and heart failure

Cell transplantation to repair or regenerate injured myocardium is a new frontier in the treatment of cardiovascular disease. Even though it is based on many years of pre-clinical studies, much remains to be understood about this methodology, even as it progresses to the clinic. For example, controversies exist over the specific cells to be used, the dosages needed for tissue repair, how cells will affect the electrical activity of the myocardium, and even whether the cells can improve myocardial function after transplantation — all of which are briefly reviewed here. Autologous skeletal myoblasts appear to be the most well studied and best first generation cells for cardiac repair. Yet cardiocytes and, more recently, stem cells have been proposed as cell sources for this technology. Their advantages and limitations are also discussed. Although cellular cardiomyoplasty (cell transplantation for cardiac repair) shows great pre-clinical promise, its future will heavily depend on conducting carefully controlled, randomized clinical trials with appropriate endpoints. Utilizing biologically active cells provides both an opportunity for tissue repair and the potential for not yet understood outcomes. As with any frontier, many pioneers will attempt to conquer it. But also as with any frontier, there are pitfalls and consequences to be considered that may surpass those of previous endeavors. The future thus requires careful consideration and well-designed trials rather than haste. The promise for cell transplantation is too great to be spoiled by ill-designed attempts that forget to account for the biology of both the cells and the myocardium.

Tags: cellular-cardiomyoplasty, heart-failure, ischemic-heart-disease, myoblast-transplantation, nih
Organization: U.S. Department of Health & Human Services
Is albumin gradient or fluid to serum albumin ratio better than the pleural fluid lactate dehydroginase in the diagnostic of separation of pleural effusion?

Background
          To determine the accuracy of serum-effusion albumin gradient (SEAG) and pleural fluid to serum albumin ratio (ALBR) in the diagnostic separation of pleural effusion into transudate and exudate and to compare SEAG and ALBR with pleural fluid LDH (FLDH) the most widely used test.
        
        
          Methods
          Data collected from 200 consecutive patients with a known cause of pleural effusion in a United Kingdom district general hospital.
        
        
          Results
          The median and inter quartile ranges (IQR) for SEAG 93.5 (33.8 to 122.5) g/dl, ALBR 0.49 (0.42 to 0.62) and FLDH 98.5 IU/L(76.8 to 127.5) in transudates were significantly lower than the corresponding values for exudates 308.5 (171 to 692), 0.77 (0.63 to 0.85), 344 (216 to 695) all p < 0.0001. The Area Under the Curve (AUC) with 95% confidence intervals (Cl) for SEAG, ALBR and FLDH were 0.81 (0.75 to 0.87), 0.79 (0.72 to 0.86) and 0.9 (0.87 to 0.96) respectively. The positive likelihood ratios with 95%CI for FLDH, SEAG, and ALBR were: 7.3(3.5–17), 6.3(3–15) 6.2(3–14) respectively. There was a significant negative correlation between SEAG and ALBR (r= -0.89, p < 0.0001).
        
        
          Conclusion
          The discriminative value for SEAG and ALBR appears to be similar in the diagnostic separation of transudates and exudates. FLDH is a superior test compared to SEAG and ALBR.

Tags: albumin-gradient, diagnostic-accuracy, fluid-analysis, nih, pleural-effusion
Organization: U.S. Department of Health & Human Services
Guidance About Seeking Personal Protective Equipment for Child Welfare Workers

This letter from the Children’s Bureau suggests that child welfare leaders seek to have child welfare workers and service providers classified as level 1 emergency responders, which would allow them to have greater access to personal protective equipment.

Browse All COVID-19 Resources

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: emergency, guidance, instruction, policy, response
Organization: U.S. Department of Health & Human Services
Compound 525625: N,N-Dimethyl-N'-decyl-p-methylbenzamidine

Chemical compound data from PubChem database. IUPAC Name: N'-decyl-N,N,4-trimethylbenzenecarboximidamide. Molecular Formula: C20H34N2. Molecular Weight: 302.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 525549: N-Benzylidene-3-chloroaniline

Chemical compound data from PubChem database. IUPAC Name: N-(3-chlorophenyl)-1-phenylmethanimine. Molecular Formula: C13H10ClN. Molecular Weight: 215.68. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services