AndreaBozzo/ceres-open-data-index huggingface dataset:
Altered prostanoid production by fibroblasts cultured from the lungs of human subjects with idiopathic pulmonary fibrosis

Background
          Prostanoids are known to participate in the process of fibrogenesis. Because lung fibroblasts produce prostanoids and are believed to play a central role in the pathogenesis of idiopathic pulmonary fibrosis (IPF), we hypothesized that fibroblasts (HF) cultured from the lungs of patients with IPF (HF-IPF) have an altered balance between profibrotic (thromboxane [TX]A2) and antifibrotic (prostacyclin [PGI2]) prostaglandins (PGs) when compared with normal human lung fibroblasts (HF-NL).
        
        
          Methods
          We measured inducible cyclooxygenase (COX)-2 gene and protein expression, and a profile of prostanoids at baseline and after IL-1β stimulation.
        
        
          Results
          In both HF-IPF and HF-NL COX-2 expression was undetectable at baseline, but was significantly upregulated by IL-1β. PGE2 was the predominant COX product in IL-1β-stimulated cells with no significant difference between HF-IPF and HF-NL (28.35 [9.09–89.09] vs. 17.12 [8.58–29.33] ng/106 cells/30 min, respectively; P = 0.25). TXB2 (the stable metabolite of TXA2) production was significantly higher in IL-1β-stimulated HF-IPF compared to HF-NL (1.92 [1.27–2.57] vs. 0.61 [0.21–1.64] ng/106 cells/30 min, respectively; P = 0.007) and the ratio of PGI2 (as measured by its stable metabolite 6-keto-PGF1α) to TXB2 was significantly lower at baseline in HF-IPF (0.08 [0.04–0.52] vs. 0.12 [0.11–0.89] in HF-NL; P = 0.028) and with IL-1β stimulation (0.24 [0.05–1.53] vs. 1.08 [0.51–3.79] in HF-NL; P = 0.09).
        
        
          Conclusion
          An alteration in the balance of profibrotic and antifibrotic PGs in HF-IPF may play a role in the pathogeneses of IPF.

Tags: cox-2-expression, idiopathic-pulmonary-fibrosis, lung-fibroblasts, nih, prostanoid-production
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Tennessee, 2014

This is a behavioral health report for the state of Tennessee. It uses the National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment Services (NSSATS) to address the topics of youth substance use, youth mental health and treatment, adult mental health and treatment, substance use, and substance use treatment for the years 2009 to 2013.

Tags: behavioral-health, mental-health, samhsa, substance-use, tennessee
Organization: U.S. Department of Health & Human Services
Comparison of 2010-2011 and 2011-2012 NSDUH State Prevalence Estimates

This report presents trends of estimates for measures of substance use and mental health based on the combined 2010 and 2011 and the combined 2011 and 2012 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: mental-health, nsduh-data, prevalence-estimates, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
The pro-apoptotic Bcl-2 family member tBid localizes to mitochondrial contact sites

Background
          Following cleavage by caspase 8, the C-terminus of Bid translocates from the cytosol to the mitochondria that is dependent upon structures formed by the mitochondrial-specific lipid cardiolipin. Once associated with mitochondria, truncated Bid (tBid) causes the potent release of cytochrome c, endonuclease G, and smac.
        
        
          Results
          We investigated whether tBid localizes specifically to the contact sites of mitochondria purported to be rich in cardiolipin. A point mutation changing the glycine at position 94 to glutamic acid in the BH3 domain of tBid (tBidG94E) was principally used because mitochondria treated with this mutant tBid displayed better preservation of the outer membrane than those treated with wild type tBid. Additionally, tBidG94E lowers the cytochrome c releasing activity of tBid without affecting its targeting to mitochondria. Electron microscope tomography coupled with immunogold labeling was used as a new hybrid technique to investigate the three-dimensional distributions of tBid and tBidG94E around the mitochondrial periphery. The statistics of spatial point patterns was used to analyze the association of these proteins with contact sites.
        
        
          Conclusions
          Immunoelectron tomography with statistical analysis confirmed the preferential association of tBid with mitochondrial contact sites. These findings link these sites with cardiolipin in tBid targeting and suggest a role for Bcl-2 family members in regulating the activity of contact sites in relation to apoptosis. We propose a mechanism whereby Bcl-2 proteins alter mitochondrial function by disrupting cardiolipin containing contact site membranes.

Tags: apoptosis-pathway, cytochrome-c-release, mitochondrial-localization, nih, tbid-protein
Organization: U.S. Department of Health & Human Services
Compound 528786: Estran-3-one, 17-hydroxy-, (5alpha,17beta)-

Chemical compound data from PubChem database. IUPAC Name: 17-hydroxy-13-methyl-2,4,5,6,7,8,9,10,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-one. Molecular Formula: C18H28O2. Molecular Weight: 276.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 530091: 2-Methyladenine, TMS

Chemical compound data from PubChem database. IUPAC Name: N,7-bis(trimethylsilyl)-2-trimethylsilyloxypurin-6-amine. Molecular Formula: C14H29N5OSi3. Molecular Weight: 367.67. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Alterations in osteoclast morphology following long-term 17beta-estradiol administration in the mouse

Background
          Although the role of the osteoclast in bone resorption is becoming better understood, much remains to be learned about osteoclastogenesis and the exact mechanism of action of anti-resorbing agents such as 17β-estradiol. This study investigated bone and morphologic osteoclast alterations following long-term estrogen administration to the B6D2F1 mouse. B6D2F1 mice aged 4-5 weeks were exposed to high levels of estrogen via implanted silastic tubing for at least 12 weeks; controls received empty tubing. Femurs of control and treated mice were assessed with radiology, quantitative histomorphometry and transmission electron microscopy.
        
        
          Results
          After 8 weeks of treatment, there was radiologic evidence of severe osteosclerosis and 86% of femoral marrow space was replaced with bone. After 12 weeks histologic studies of treated animals revealed that osteoclasts were positive for tartrate-resistant acid phosphatase but showed markedly abnormal ultrastructure which prevented successful bone resorption.
        
        
          Conclusions
          Findings extend our understanding of osteoclast structure and function in the mouse exposed in vivo to high doses of estrogen. Ultrastructural examination showed that osteoclasts from estrogen-treated mice were unable to seal against the bone surface and were unable to form ruffled borders.

Tags: bone-resorption, estradiol-administration, nih, osteoclast-morphology, osteosclerosis
Organization: U.S. Department of Health & Human Services
Compound 530527: 5-Chlorovaleric acid, tridecyl ester

Chemical compound data from PubChem database. IUPAC Name: tridecyl 5-chloropentanoate. Molecular Formula: C18H35ClO2. Molecular Weight: 318.9. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Patent AT-E400629-T1: [Translated] FCC PROCESS FOR UPGRADING MEDIUM BOILING RANGE GASOLINE

An FCC process converts a secondary feed comprising a heart of a gasoline product stream with spent catalyst at mild conditions to obtain a surprising increase in the octane number of the resulting gasoline product. More surprisingly, the increase in gasoline stream octane number occurs with very low production of dry gas. Limiting the presence of heavy gasoline components was found to significantly raise the octane number produced by the process.

Tags: chemistry, innovation, patent, pubchem, research
Organization: U.S. Department of Health & Human Services
Development of an optimized interaction-mating protocol for large-scale yeast two-hybrid analyses

Background
          Protein-protein interactions have decisive roles in almost all aspects of the structural and functional organization of cells. But in spite of the increasing amount of complete genome sequence data, the ability to predict protein function from sequences alone is limited. Therefore comprehensive analysis of protein-protein interactions, as derived from the yeast two-hybrid mating system, will yield valuable information for functional biology on a proteomic scale.
        
        
          Results
          We have developed an optimized interaction mating protocol for the yeast two-hybrid system, which gives increased mating efficiencies. This significantly reduces the effort and cost of cDNA library screening and allows multiple parallel approaches. Improved preincubation conditions before mating, and optimal cell densities and cell ratios enable almost quantitative mating of the yeast cells carrying the cDNA library. We have proved the applicability of this technology using 20 bait proteins to screen an Arabidopsis thaliana cDNA library, in spite of bait-dependent variations in mating efficiency.
        
        
          Conclusions
          The improved yeast two-hybrid interaction-mating protocol presented here allows the multiple parallel screening of cDNA libraries. It can be carried out without specialized equipment and has the potential to be standardized and automated.

Tags: mating-protocol, nih, protein-interactions, proteomic-analysis, yeast-two-hybrid
Organization: U.S. Department of Health & Human Services
Compound 527514: 1-(1-Methylpropyl)-1H-pyrrole

Chemical compound data from PubChem database. IUPAC Name: 1-butan-2-ylpyrrole. Molecular Formula: C8H13N. Molecular Weight: 123.2. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2018-2019 NSDUH: Other Sources of State-Level Data

This document briefly describes one of these other data systems that publish state estimates and presents selected comparisons with NSDUH results: Behavioral Risk Factor Surveillance System (BRFSS) and Youth Risk Behavior Survey (YRBS).

Tags: behavioral-risk-factors, samhsa, substance-use-comparison, survey, youth-risk-behavior
Organization: U.S. Department of Health & Human Services
Lack of microbiological concordance between bone and non-bone specimens in chronic osteomyelitis: an observational study

Background
          Prognosis of chronic osteomyelitis depends heavily on proper identification and treatment of the bone-infecting organism. Current knowledge on selecting the best specimen for culture is confusing, and many consider that non-bone specimens are suitable to replace bone cultures. This paper compares the microbiology of non-bone specimens with bone cultures, taking the last as the diagnostic gold standard.
        
        
          Methods
          Retrospective observational analysis of 50 patients with bacterial chronic osteomyelitis in a 750-bed University-based hospital.
        
        
          Results
          Concordance between both specimens for all etiologic agents was 28%, for Staphylococcus aureus 38%, and for organisms other than S. aureus 19%. The culture of non-bone specimens to identify the causative organisms in chronic osteomyelitis produced 52% false negatives and 36% false positives when compared against bone cultures.
        
        
          Conclusions
          Diagnosis and therapy of chronic osteomyelitis cannot be guided by cultures of non-bone specimens because their microbiology is substantially different to the microbiology of the bone.

Tags: bone-infection, diagnostic-accuracy, nih, osteomyelitis-microbiology, specimen-culture
Organization: U.S. Department of Health & Human Services
Compound 527298: n-Butylmesitylene

Chemical compound data from PubChem database. IUPAC Name: 2-butyl-1,3,5-trimethylbenzene. Molecular Formula: C13H20. Molecular Weight: 176.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Results of a phase-I/II randomized, masked, placebo-controlled trial of recombinant human interleukin-11 (rhIL-11) in the treatment of subjects with active rheumatoid arthritis

Interleukin-11 (IL-11) is a pleiotropic cytokine that regulates the growth and development of hematopoietic stem cells and decreases the proinflammatory mediators of cytokine and nitric oxide production. In animal models of arthritis, treatment with recombinant human IL-11 (rhIL-11) reduces both the level of synovitis and the histologic lesion scores in the joints.
        The goal of this phase-I/II study in adults with rheumatoid arthritis (RA) was to evaluate the safety and clinical activity of different doses and schedules of rhIL-11 in patients with active RA for whom treatment with at least one disease-modifying antirheumatic drug had failed.
        This was a multicenter, randomized, placebo-controlled trial that evaluated the safety and tolerability of rhIL-11 in 91 patients with active RA. rhIL-11 was administered subcutaneously; patients were randomized into one of five treatment groups (ratio of rhIL-11 to placebo, 4:1). Patients were treated for 12 weeks with either 2.5 or 7.5 μg/kg of rhIL-11 or placebo twice per week or 5 or 15 μg/kg of rhIL-11 or placebo once per week. The status of each subject's disease activity in accordance with the American College of Rheumatology (ACR) criteria was assessed before, during, and after completion of administration of the study drug.
        Administration of rhIL-11 was well tolerated at all doses and schedules. The most frequent adverse event was a reaction at the injection site. The data suggest a statistically significant reduction in the number of tender joints (P < 0.008) at the 15 μg/kg once-weekly dose schedule but showed no overall significant benefit at the ACR criterion of a 20% response.
        The trial showed rhIL-11 to be safe and well tolerated at a variety of doses and schedules over a 12-week treatment period in patients with active RA. The only adverse event clearly associated with rhIL-11 administration was reaction at the injection site.

Tags: anti-inflammatory, clinical-trial, interleukin-11, nih, rheumatoid-arthritis
Organization: U.S. Department of Health & Human Services
Cellular responses to

Background
          Plasmodium falciparum erythrocyte membrane protein-1, a variant antigen of the malaria parasite, is potentially a target for the immune response. It would be important to determine whether there are CD4 T cells that recognise conserved regions. However, within the relatively conserved region, there is variation. It is not possible to test T cell responses from small field samples with all possible peptides.
        
        
          Methods
          We have aligned sequences that are relatively conserved between several PfEMP1 molecules, and chosen a representative sequence similar to most of the PfEMP1 variants. Using these peptides as pools representing CIDRα, CIDRβ and DBLβ-δ domains, DBLα domain, and EXON 2 domain of PfEMP1, we measured the CD4 T cell responses of malaria-exposed donors from Benin, West Africa by a FACS based assay.
        
        
          Results
          All the three peptide pools elicited a CD4 T cell response in a proportion of malaria-exposed and non-exposed donors. CD4 T cell proliferation occurs at a relatively higher magnitude to peptide pools from the DBLα and EXON 2 in the malaria-exposed donors living in Benin than in the UK malaria-unexposed donors.
        
        
          Conclusions
          These findings suggest that an immunological recall response to conserved peptides of a variant antigen can be measured. Further testing of individual peptides in a positive pool will allow us to determine those conserved sequences recognised by many individuals. These types of assays may provide information on conserved peptides of PfEMP1 which could be useful for stimulating T cells to provide help to P. falciparum specific B cells.

Tags: benin-cohort, cd4-t-cells, malaria-immunity, nih, pfemp1-antigen
Organization: U.S. Department of Health & Human Services
Compound 529193: 3-Oxa-6-aza-2,7-disilaoctane, 2,2,7,7-tetramethyl-6-(trimethylsilyl)-

Chemical compound data from PubChem database. IUPAC Name: N,N-bis(trimethylsilyl)-2-trimethylsilyloxyethanamine. Molecular Formula: C11H31NOSi3. Molecular Weight: 277.63. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Patent AT-E399934-T1: [Translated] ELECTRICAL BYPASS IN FUEL INJECTORS

Disclosed is a fuel injector in which at least one electrically triggered valve is disposed inside an injector member and is connected to an externally accessible injector member contact by means of a solid conductor, the solid conductor and the electrical valve contact being interconnected directly via an electrically conducting positive connection or indirectly via an electrically conducting connecting element. The solid conductor is configured so as to substantially maintain the shape thereof under the influence of the proper weight thereof.

Tags: chemistry, innovation, patent, pubchem, research
Organization: U.S. Department of Health & Human Services
Prior Relationship of Adoptive Parent(s) to Child: 10/1/2004 - 9/30/2005

This report provides state-specific data from fiscal year 2005 about the prior relationships of the adoptive parents to the children who were adopted through public agencies.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: adoption, child, data, fiscal, policy
Organization: U.S. Department of Health & Human Services
Oklahoma: 2011-2012 NSDUH

This report presents Oklahoma\'s estimates for 25 measures of substance use and mental health based on the combined 2011 and 2012 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided by State and for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: mental-health, oklahoma-nsduh, samhsa, serious-mental-illness, substance-use
Organization: U.S. Department of Health & Human Services
Compound 525048: 3'-Chloro,4'-methylcapryloanilide

Chemical compound data from PubChem database. IUPAC Name: N-(3-chloro-4-methylphenyl)octanamide. Molecular Formula: C15H22ClNO. Molecular Weight: 267.79. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
In what extent anemia coexists with cognitive impairment in elderly: a cross-sectional study in Greece

Background
          A project aimed at studying the frequency of dementia and depression in the catchment area of the Health Centre of Chrissoupolis (HCCh), Northern Greece, was carried out. This paper reports the association between AD and anemia among the elderly participants in this Greek study.
        
        
          Methods
          Eligible participants were people 65 years or over who were (a) living in the Elderly People's Home (all 48 subjects included); (b) visiting the Open Center for Elderly People during a 20 workday period (75 subjects) and (c) visiting the HCCh for routine medical care. The Mini Mental State Examination (MMSE) was used in assessing the cognitive capacity of the participants. Blood was drawn for serum hematocrit, vitamin B12 and folate determination.
        
        
          Results
          The prevalence proportions of possible cognitive impairment among anemic and non-anemic males were 55.6% and 34.4%, respectively (X2 = 5.8, d.f. = 1, p = 0.016). The corresponding proportions in females were 47.5% and 40.1 % (X2 = 1.1, d.f. = 1, p = 0.305). Using logistic regression analysis, age-group (≥ 80 yrs), type of Institute, vitamin B12 and anemia had significant independent associations with possible cognitive impairment.
        
        
          Conclusions
          Anemia is a frequent finding in elderly and it may be a risk factor for dementia, but the extent of the associated deterioration of cognitive impairment or the relation with AD is not known. GPs should be aware of this coexistence and recommend for screening, assaying and treating elderly people.

Tags: anemia, cognitive-impairment, elderly-health, greece, nih
Organization: U.S. Department of Health & Human Services
Compound 528040: 10,13-dimethyl-3,17-bis(trimethylsilyloxy)-17-(1-trimethylsilyloxyethyl)-2,3,4,5,6,7,8,9,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-11-one

Chemical compound data from PubChem database. IUPAC Name: 10,13-dimethyl-3,17-bis(trimethylsilyloxy)-17-(1-trimethylsilyloxyethyl)-2,3,4,5,6,7,8,9,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-11-one. Molecular Formula: C30H58O4Si3. Molecular Weight: 567.0. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 528953: Phenol, 2-(1-methylbutyl)-6-nitro

Chemical compound data from PubChem database. IUPAC Name: 2-nitro-6-pentan-2-ylphenol. Molecular Formula: C11H15NO3. Molecular Weight: 209.24. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services