AndreaBozzo/ceres-open-data-index huggingface dataset:
Compound 528329: Furfuryl pentyl sulfide

Chemical compound data from PubChem database. IUPAC Name: 1-(pentylsulfanylmethyl)cyclopenta-1,3-diene. Molecular Formula: C11H18S. Molecular Weight: 182.33. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
UAG readthrough in mammalian cells: Effect of upstream and downstream stop codon contexts reveal different signals

Background
          Translation termination is mediated through an interaction between the release factors eRF1 and eRF3 and the stop codon within its nucleotide context. Although it is well known that the nucleotide contexts both upstream and downstream of the stop codon, can modulate readthrough, little is known about the mechanisms involved.
        
        
          Results
          We have performed an in vivo analysis of translational readthrough in mouse cells in culture using a reporter system that allows the measurement of readthrough levels as low as 10-4. We first quantified readthrough frequencies obtained with constructs carrying different codons (two Gln, two His and four Gly) immediately upstream of the stop codon. There was no effect of amino acid identity or codon frequency. However, an adenine in the -1 position was always associated with the highest readthrough levels while an uracil was always associated with the lowest readthrough levels. This could be due to an effect mediated either by the nucleotide itself or by the P-site tRNA. We then examined the importance of the downstream context using eight other constructs. No direct correlation between the +6 nucleotide and readthrough efficiency was observed.
        
        
          Conclusions
          We conclude that, in mouse cells, the upstream and downstream stop codon contexts affect readthrough via different mechanisms, suggesting that complex interactions take place between the mRNA and the various components of the translation termination machinery. Comparison of our results with those previously obtained in plant cells and in yeast, strongly suggests that the mechanisms involved in stop codon recognition are conserved among eukaryotes.

Tags: mammalian-cells, nih, stop-codon-context, translation-termination, uag-readthrough
Organization: U.S. Department of Health & Human Services
Compound 528548: Hexadecane, 8-undecyl

Chemical compound data from PubChem database. IUPAC Name: 9-heptylicosane. Molecular Formula: C27H56. Molecular Weight: 380.7. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Tribal Child Welfare Data System Procurement Webinar Series - Part 3: Contract Considerations

The Children's Bureau Division of State Systems and the Capacity Building Center for Tribes hosted a three-part webinar series on Tribal Child Welfare Data System Procurement.

This webinar series provides a detailed framework of best practices in planning for and procuring a new case management system. Participants hear directly from tribal staff about their process for selecting and implementing a data system. In addition, facilitators connect participants with resources, technical assistance, and peer supports.

Part 3 - Contracting with Data System Vendors

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: case, child, policy, reporting, scope
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Region 7, Volume 5

This is a behavioral health report for HHS Region VII of the United States and utilizes data from the National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment (N-SSATS), collected annually. The topics addressed in the reports include youth mental health and treatment, substance use and substance use treatment.

Tags: behavioral-health, mental-health, samhsa, substance-use, youth-mental-health
Organization: U.S. Department of Health & Human Services
2019 Uniform Reporting System (URS) Table for Arizona

These are the 2019 Uniform Reporting System (URS) Output Tables for Arizona. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: arizona, block-grant-data, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
AFCARS Foster Care and Adoption Data Elements in the Appendix to 45 CFR part 1355

This is a list of the Foster Care and Adoption data elements as currently published in the Appendix to 45 CFR part 1355
  
  

.These are the data elements that are currently being reported and have been reported by title IV-E agencies since 1993.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: adoption, data, foster, policy, reporting
Organization: U.S. Department of Health & Human Services
Letter to Child Welfare Directors on Protecting Credit of Young People in Foster Care

This letter to child welfare directors urges agencies to consider taking additional steps to protect children and youth from identity theft and to explore how to implement the provision to empower youth by deepening their understanding of credit, money management, and other financial issues.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: fiscal, foster, guidance, policy, prevention
Organization: U.S. Department of Health & Human Services
Compound 525536: (4-Hexyloxy-phenyl)-acetic acid, methyl ester

Chemical compound data from PubChem database. IUPAC Name: methyl 2-(4-hexoxyphenyl)acetate. Molecular Formula: C15H22O3. Molecular Weight: 250.33. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Medication Prescribing and Behavioral Treatment for Substance Use Disorders in Physician Office Settings

This report looks at costs for substance use disorder treatment reported in the 2010 National Ambulatory Medical Care Survey. These data include costs for prescriptions for medications and behavioral treatment used to treat alcohol use disorders and opioid use disorders made in office visits to general and family practice physicians as well as specialty practitioners.

Tags: ambulatory-care, behavioral-therapy, prescription-medications, samhsa, substance-use-disorders
Organization: U.S. Department of Health & Human Services
Routine prophylactic antibiotic use in the management of snakebite

Background
          Routine antibiotic prophylaxis following snakebite is not recommended but evidence suggests that it may be common practice in Zimbabwe. This study set out to determine and describe the extent of this practice at Parirenyatwa Hospital, a large teaching hospital in Zimbabwe
        
        
          Methods
          A retrospective case review (1996 to 1999 inclusive) of all cases of snakebite was undertaken at Parirenyatwa Hospital. Cases with a diagnosis of snakebite, presenting within 24 hours of the bite and with no complications or concurrent illness were defined as "routine prophylactic antibiotic use".
        
        
          Results
          From 78 cases which satisfied the inclusion criteria, 69 (88.5%) received antibiotics. Ten different antibiotics from 6 different classes were used with penicillins the most commonly prescribed (benzylpenicillin in 29% of cases, alone or in combination). Over 40% of antibiotics were given parenterally although all patients were conscious on admission. The total cost of antibiotics used was estimated at US$522.98.
        
        
          Conclusion
          Routine prophylactic use of antibiotics in snakebite at Parirenyatwa Hospital is common practice. This may highlight the lack of a clearly defined policy leading to wasteful inappropriate antibiotic use which is costly and may promote bacterial antibiotic resistance. Further work is required to investigate the reasons for this practice and to design appropriate interventions to counter it.

Tags: antibiotic-prophylaxis, nih, retrospective-study, snakebite-treatment, zimbabwe-healthcare
Organization: U.S. Department of Health & Human Services
State Estimates of Adolescent Marijuana Use and  Perceptions of Risk of Harm From Marijuana Use: 2013 and 2014

This short report uses 2013 to 2014 National Survey on Drug Use and Health (NSDUH) to assess marijuana risk perception and marijuana use among adolescents aged 12 to 17 by State. Results are shown by State for 2002-2003 and 2013-2014.

Tags: adolescent-marijuana-use, marijuana-risk-perception, nsduh-data, samhsa, state-level-estimates
Organization: U.S. Department of Health & Human Services
Inflammatory microcrystals induce murine macrophage survival and DNA synthesis

The interaction of particulates with resident macrophages is a consistent feature in certain forms of crystal-induced inflammation, for example, in synovial tissues, lung, and the peritoneum. The mitogenic activity of basic calcium phosphate (BCP) crystals and calcium pyrophosphate dihydrate (CPPD) crystals on synovial fibroblasts has been considered relevant to the synovial hyperplasia observed in crystal-induced arthritis. The aim of the study was to determine whether microcrystals such as these could enhance macrophage survival and induce DNA synthesis, thus indicating that they may contribute to the tissue hyperplasia.
        Murine bone-marrow-derived macrophages were treated in vitro with microcrystals, the cell numbers were monitored over time, and DNA synthesis was measured as the incorporation of [methyl-3H]thymidine (TdR). We report here that BCP, monosodium urate, talc, and, to a lesser extent, CPPD crystals promote macrophage survival and DNA synthesis; the latter response is particularly striking in the presence of low concentrations of macrophage-colony stimulating factor (M-CSF, CSF-1). Enhanced macrophage survival or proliferation may contribute to the synovial hyperplasia noted in crystal-associated arthropathies, as well as to talc-induced inflammation and granuloma formation. The crystals studied join the list of particulates having these effects on macrophages, indicating the generality of this type of response.

Tags: crystal-induced-inflammation, dna-synthesis, macrophage-survival, murine-model, nih
Organization: U.S. Department of Health & Human Services
Patterns in abundance and diversity of faecally dispersed parasites of tiger in Tadoba National Park, central India

Background
          Importance of parasites in ecological and evolutionary interactions is being increasingly recognized. However, ecological data on parasites of important host species is still scanty. We analyze the patterns seen in the faecal parasites of tigers in the Tadoba National Park, India, and speculate on the factors and processes shaping the parasite community and the possible implications for tiger ecology.
        
        
          Results
          The prevalence and intensities were high and the parasite community was dominated by indirect life cycle parasites. Across all genera of parasites variance scaled with the square of the mean and there was a significant positive correlation between prevalence and abundance. There was no significant association between different types of parasites.
        
        
          Conclusions
          The 70 samples analyzed formed 14 distinct clusters. If we assume each of the clusters to represent individual tigers that were sampled repeatedly and that resident tigers are more likely to be sampled repeatedly, the presumed transient tigers had significantly greater parasite loads than the presumed resident ones.

Tags: fecal-parasite-analysis, nih, tadoba-national-park, tiger-parasites, wildlife-parasitology
Organization: U.S. Department of Health & Human Services
Compound 528507: Hexadecane, 3-octyl

Chemical compound data from PubChem database. IUPAC Name: 9-ethyldocosane. Molecular Formula: C24H50. Molecular Weight: 338.7. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 527339: 2-(3-Methylphenyl)-adamantane

Chemical compound data from PubChem database. IUPAC Name: 2-(3-methylphenyl)adamantane. Molecular Formula: C17H22. Molecular Weight: 226.36. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Different conformations of nascent polypeptides during translocation across the ER membrane

Background
          In eukaryotic cells, proteins are translocated across the ER membrane through a continuous ribosome-translocon channel. It is unclear to what extent proteins can fold already within the ribosome-translocon channel, and previous studies suggest that only a limited degree of folding (such as the formation of isolated α-helices) may be possible within the ribosome.
        
        
          Results
          We have previously shown that the conformation of nascent polypeptide chains in transit through the ribosome-translocon complex can be probed by measuring the number of residues required to span the distance between the ribosomal P-site and the lumenally disposed active site of the oligosaccharyl transferase enzyme (J. Biol. Chem 271: 6241-6244).Using this approach, we now show that model segments composed of residues with strong helix-forming properties in water (Ala, Leu) have a more compact conformation in the ribosome-translocon channel than model segments composed of residues with weak helix-forming potential (Val, Pro).
        
        
          Conclusions
          The main conclusions from the work reported here are (i) that the propensity to form an extended or more compact (possibly α-helical) conformation in the ribosome-translocon channel does not depend on whether or not the model segment has stop-transfer function, but rather seems to reflect the helical propensities of the amino acids as measured in an aqueous environment, and (ii) that stop-transfer sequences may adopt a helical structure and integrate into the ER membrane at different times relative to the time of glycan addition to nearby upstream glycosylation acceptor sites.

Tags: endoplasmic-reticulum, nih, polypeptide-conformation, protein-translocation, ribosome-translocon
Organization: U.S. Department of Health & Human Services
2012 Uniform Reporting System (URS) Tables for New Jersey

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2012. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-data, community-mental-health, mental-health-services, noms-measures, samhsa
Organization: U.S. Department of Health & Human Services
2016 Uniform Reporting System (URS) Table for Nevada

This is the 2016  Uniform Reporting System (URS) Output Tables for Nevada. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant, mental-health-services, nevada, noms, samhsa
Organization: U.S. Department of Health & Human Services
Atrial fibrillation in a primary care practice: prevalence and management

Background
          Atrial fibrillation is a common serious cardiac arrhythmia. Knowing the prevalence of atrial fibrillation and documentation of medical management are important in the provision of primary care. This study sought to determine the prevalence of atrial fibrillation in a primary care population and to identify and quantify the treatments being used for stroke prevention in this group of patients.
        
        
          Methods
          A prevalence study through chart audit was conducted in the family medicine practice at the Sunnybrook campus of the Sunnybrook and Women's College Health Sciences Centre. The main outcome measures were the prevalence of atrial fibrillation in our primary care practice and the use of warfarin for stroke prevention in this population.
        
        
          Results
          261 patients in our practice have atrial fibrillation. The overall prevalence in our family practice unit is 3.9%. When considering patients aged 60 and over, the prevalence rises to 12.2%. 204 of our patients with atrial fibrillation (78.2%) are currently being treated with warfarin. Another 21 patients were previously treated and discontinued for a number of reasons. Of the 57 patients not currently treated with warfarin, 44 are treated with ASA, 2 with ticlopidine, and 11 are receiving no preventative treatment.
        
        
          Conclusions
          The prevalence of atrial fibrillation in our practice is higher than the range of prevalence reported in the general literature. However, our coverage with warfarin treatment exceeds previous reports in the literature.

Tags: atrial-fibrillation, nih, primary-care, stroke-prevention, warfarin-use
Organization: U.S. Department of Health & Human Services
2014 CMHS Uniform Reporting System (URS) Table for Wyoming

2014 Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for Wyoming. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: mental-health-services, outcome-measures, samhsa, urs-data, wyoming
Organization: U.S. Department of Health & Human Services
Writing and Evaluating an RFP

This webinar, sponsored by the Children's Bureau's Division of State Systems, is the second webinar in the FY2014 Back to Basics: Procurement and Project Management series. Do Vendor responses to your RFP's leave you scratching your head wondering what they were thinking when they read the RFP? This webinar provided a vendor's perspective on how they interpret State RFP's and what factors go into a Bid/No Bid decision. Information was provided on how States can write their RFP's to represent more attractive opportunities for qualified bidders without compromising the integrity of State requirements. The webinar includes time for Q&A and audience discussion.

This webinar was moderated by Joyce Rose, consultant to ICF International. The presenter was Dave Jennings, Director Business Development, State and Local Government Solutions SLI Global Solutions.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: policy, public, scope, state, system
Organization: U.S. Department of Health & Human Services
Compound 528460: 1-Tetradecene, 10-butyl

Chemical compound data from PubChem database. IUPAC Name: 10-butyltetradec-1-ene. Molecular Formula: C18H36. Molecular Weight: 252.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Nebraska: 2011-2012 NSDUH

This report presents Nebraska\'s estimates for 25 measures of substance use and mental health based on the combined 2011 and 2012 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided by State and for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: mental-health, nebraska-data, nsduh-survey, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Compound 528549: Nonadecane, 2,6,10,15-tetramethyl

Chemical compound data from PubChem database. IUPAC Name: 2,6,10,15-tetramethylnonadecane. Molecular Formula: C23H48. Molecular Weight: 324.6. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2010 CMHS Uniform Reporting System (URS) Output Tables for Montana

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2010. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-program, community-mental-health, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Effects of intravenous furosemide on mucociliary transport and rheological properties of patients under mechanical ventilation

The use of intravenous (IV) furosemide is common practice in patients under mechanical ventilation (MV), but its effects on respiratory mucus are largely unknown. Furosemide can affect respiratory mucus either directly through inhibition of the NaK(Cl)2 co-transporter on the basolateral surface of airway epithelium or indirectly through increased diuresis and dehydration. We investigated the physical properties and transportability of respiratory mucus obtained from 26 patients under MV distributed in two groups, furosemide (n = 12) and control (n = 14). Mucus collection was done at 0, 1, 2, 3 and 4 hours. The rheological properties of mucus were studied with a microrheometer, and in vitro mucociliary transport (MCT) (frog palate), contact angle (CA) and cough clearance (CC) (simulated cough machine) were measured. After the administration of furosemide, MCT decreased by 17 ± 19%, 24 ± 11%, 18 ± 16% and 18 ± 13% at 1, 2, 3 and 4 hours respectively, P < 0.001 compared with control. In contrast, no significant changes were observed in the control group. The remaining parameters did not change significantly in either group. Our results support the hypothesis that IV furosemide might acutely impair MCT in patients under MV.

Tags: furosemide-effects, mechanical-ventilation, mucociliary-transport, mucus-rheology, nih
Organization: U.S. Department of Health & Human Services