AndreaBozzo/ceres-open-data-index huggingface dataset:
2016 Uniform Reporting System (URS) Table for New York

This is the 2016 Uniform Reporting System (URS) Output Tables for New York. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-data, evidence-based-practices, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Compound 525387: 2,6,6-Trimethyl-5-thiaheptane

Chemical compound data from PubChem database. IUPAC Name: 1-tert-butylsulfanyl-3-methylbutane. Molecular Formula: C9H20S. Molecular Weight: 160.32. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Tobacco Product and Alcohol Use Tables (Prevalence Estimates) - 2.1 to 2.84

These detailed tables are population tobacco and alcohol use totals and prevalence estimates from the 2012 National Survey on Drug Use and Health (NSDUH). Tobacco products include cigarettes, smokeless tobacco, cigars, and pipe tobacco. Alcohol use includes binge and heavy alcohol use. Results are provided for lifetime, past year, and past month use by age group, gender, race/ethnicity, education level, employment status, and geographic area. Comparisons are made between 2012 and 2011.

Tags: behavioral-health-survey, nsduh-2012, samhsa, substance-use-prevalence, tobacco-alcohol-use
Organization: U.S. Department of Health & Human Services
Preparation of pure and intact

Background
          In host erythrocytes, the malaria parasite must contend with ion and drug transport across three membranes; its own plasma membrane, the parasitophorous membrane and the host plasma membrane. Isolation of pure and intact Plasmodium falciparum plasma membrane would provide a suitable model to elucidate the possible role played by the parasite plasma membrane in ion balance and drug transport.
        
        
          Results
          This study describes a procedure for isolating parasite plasma membrane from P. falciparum-infected erythrocytes. With this method, the trophozoites released by saponin treatment were cleansed of erythrocyte membranes using anti-erythrocyte antibodies fixed to polystyrene beads. These trophozoites were then biotinylated and the parasite plasma membrane was disrupted by nitrogen cavitation. This process allows the membranes to reform into vesicles. The magnetic streptavidin beads bind specifically to the biotinylated parasite plasma membrane vesicles facilitating their recovery with a magnet. These vesicles can then be easily released from the magnetic beads by treatment with dithiotreithol. The parasite plasma membrane showed optimal ATPase activity at 2 mM ATP and 2 mM Mg2+. It was also found that Ca2+ could not substitute for Mg2+ ATPase activity in parasite plasma membranes whereas activity was completely preserved when Mn2+ was used instead of Mg2+. Other nucleoside triphosphates tested were hydrolysed as efficiently as ATP, while the nucleoside monophosphate AMP was not.
        
        
          Conclusions
          We have described the successful isolation of intact P. falciparum plasma membrane vesicles free of contaminating organelles and determined the experimental conditions for optimum ATPase activity.

Tags: malaria, malaria-research, nih, parasite-membrane, plasmodium-falciparum
Organization: U.S. Department of Health & Human Services
Clues to the etiology of autoimmune diseases through analysis of immunoglobulin genes

The role of autoantibodies in the etiology of autoimmune diseases remains unclear. However, an examination of the sequences of these autoantibodies can be informative. Antibody sequences that violate constraints normally imposed during ontogeny and during development point to a failure of regulation. The existence of clonally related sequences indicates that production of these antibodies may frequently be driven by self-antigen. A better understanding of the mechanisms that normally constrain the composition of the antibody repertoire and of the nature of the inciting and/or driving antigens may yield new insights into both the pathogenesis and potential treatment of these crippling diseases.

Tags: autoantibody-sequences, autoimmune-diseases, b-cell-repertoire, immunoglobulin-genes, nih
Organization: U.S. Department of Health & Human Services
Statistical issues in randomized trials of cancer screening

Background
          The evaluation of randomized trials for cancer screening involves special statistical considerations not found in therapeutic trials. Although some of these issues have been discussed previously, we present important recent and new methodologies.
        
        
          Methods
          Our emphasis is on simple approaches.
        
        
          Results
          We make the following recommendations:
          (1) Use death from cancer as the primary endpoint, but review death records carefully and report all causes of death
          (2) Use a simple "causal" estimate to adjust for nonattendance and contamination occurring immediately after randomization
          (3) Use a simple adaptive estimate to adjust for dilution in follow-up after the last screen
        
        
          Conclusion
          The proposed guidelines combine recent methodological work on screening endpoints and noncompliance/contamination with a new adaptive method to adjust for dilution in a study where follow-up continues after the last screen. These guidelines ensure good practice in the design and analysis of randomized trials of cancer screening.

Tags: cancer-screening, mortality-analysis, nih, randomized-trials, statistical-methods
Organization: U.S. Department of Health & Human Services
Complex trait analysis of the mouse striatum: independent QTLs modulate volume and neuron number

Background
          The striatum plays a pivotal role in modulating motor activity and higher cognitive function. We analyzed variation in striatal volume and neuron number in mice and initiated a complex trait analysis to discover polymorphic genes that modulate the structure of the basal ganglia.
        
        
          Results
          Brain weight, brain and striatal volume, neuron-packing density and number were estimated bilaterally using unbiased stereological procedures in five inbred strains (A/J, C57BL/6J, DBA/2J, BALB/cJ, and BXD5) and an F2 intercross between A/J and BXD5. Striatal volume ranged from 20 to 37 mm3. Neuron-packing density ranged from approximately 50,000 to 100,000 neurons/mm3, and the striatal neuron population ranged from 1.4 to 2.5 million. Inbred animals with larger brains had larger striata but lower neuron-packing density resulting in a narrow range of average neuron populations. In contrast, there was a strong positive correlation between volume and neuron number among intercross progeny. We mapped two quantitative trait loci (QTLs) with selective effects on striatal architecture. Bsc10a maps to the central region of Chr 10 (LRS of 17.5 near D10Mit186) and has intense effects on striatal volume and moderate effects on brain volume. Stnn19a maps to distal Chr 19 (LRS of 15 at D19Mit123) and is associated with differences of up to 400,000 neurons among animals.
        
        
          Conclusion
          We have discovered remarkable numerical and volumetric variation in the mouse striatum, and we have been able to map two QTLs that modulate independent anatomic parameters.

Tags: basal-ganglia, mouse-brain, neuron-number, nih, striatum-volume
Organization: U.S. Department of Health & Human Services
Preoperative Acute Normovolaemic Hemodilution (ANH) in combination with Hypotensive Epidural Anaesthesia (HEA) during knee arthroplasty surgery. No effect on transfusion rate. A randomized controlled trial [ISRCTN87597684]

Background
          Hypotensive epidural anaesthesia (HEA) combines a high epidural anaesthesia, performing a sympathetic blockade, with low-dose iv-infusion of epinephrine to stabilize circulation in the conscious patient. Mean artery blood pressure is reduced to 45–50 mmHg and hereby a reduced blood loss. In this study we have combined HEA with preoperative acute normovolaemic hemodilution (ANH) in attempt to further reduce the blood loss and need for blood transfusion in total knee arthroplasty surgery (TKR).
        
        
          Methods
          Twenty-eight patients scheduled for TKR are randomised to ANH or no hemodilution (non-ANH). Both groups are anaesthetized with HEA. ANH is established with predonation of 20 % of the total blood volume, and replacement with equal volume of HAES 6 %. Blood re-transfusion is completed within 6 h.
        
        
          Results
          A mean of 877 ml blood was predonated (19.7 % of the total blood volume). Blood loss was, except from the intraoperative loss, significantly higher in ANH group. The total loss was 1306 mL (ANH) vs. 1026 mL (non-ANH), p < 0.05. Except from the first hour postoperatively, hematocrit was identical in between groups postoperatively. The amount of blood transfusion was identical 386 ml (ANH) vs. 343 ml (non-ANH) (ns). 50 % went through surgery without receiving blood (ANH) vs. 58 % (non-ANH). No renal, neurological or cardiopulmonary complications were registered.
        
        
          Conclusions
          These data suggest no benefits in combining HEA and ANH in TKR surgery. Probably because of the reduced viscosity of the blood after ANH, there is an increased postoperative blood loss. The need for homologous blood transfusion was identical.

Tags: blood-transfusion, epidural-anesthesia, knee-arthroplasty, nih, normovolemic-hemodilution
Organization: U.S. Department of Health & Human Services
Compound 525255: N''-Butyl-N,N,N',N'-tetramethyl-guanidine

Chemical compound data from PubChem database. IUPAC Name: 2-butyl-1,1,3,3-tetramethylguanidine. Molecular Formula: C9H21N3. Molecular Weight: 171.28. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Vermont: 2011-2012 NSDUH

This report presents Vermont\'s estimates for 25 measures of substance use and mental health based on the combined 2011 and 2012 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided by State and for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: mental-health, samhsa, substance-use, suicidal-ideation, vermont-nsduh
Organization: U.S. Department of Health & Human Services
2012 Uniform Reporting System (URS) Tables for Alaska

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2012. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: alaska-mental-health, mental-health-services, noms-measures, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Ohio, 2014

This is a behavioral health report for the state of Ohio. It uses the  National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment Services (NSSATS) to address the topics of youth substance use , youth mental health and treatment, adult mental health and treatment, substance use, substance use treatment, and medicare enrollees for the years 2009 to 2013.

Tags: adult-mental-health, ohio-behavioral-health, samhsa, substance-abuse-treatment, youth-substance-use
Organization: U.S. Department of Health & Human Services
2010 National Survey of Substance Abuse Treatment Services (N-SSATS) HHS Regional Report

This is a National Survey of Substance Abuse Treatment Services (N-SSATS) regional report that focuses on the rate of clients in treatment for substance abuse in 2010.  There are 10 Department of Health and Human Services regions. The National Survey of Substance Abuse Treatment Services (N-SSATS) is an annual census of facilities in the United States, both public and private, that provide substance abuse treatment.

Tags: hhs-regions, n-ssats, samhsa, substance-abuse-treatment, treatment-facilities
Organization: U.S. Department of Health & Human Services
Emergency Department Visits Involving the Accidental Ingestion of Opioid Pain Relievers by Children Aged 1 to 5

This short report uses data from the Drug Abuse Warning Network (DAWN) to examine the emergency department (ED) visits for children aged 1 -5 that involved opioid pain relievers.  Hydrocodone (Vicodin, Lortab), oxycodone (OxyContin, Percocet), and codeine are examples of opioid pain relievers; buprenorphine (Suboxone), is an opioid that is used to treat opoioid dependence. The report reviews the trends in ED visits involving the accidental ingestion of opioid pain relievers by children from 2004 to 2011. Data from 2004 to 2011 are combined and analyzed to identify the opioid pain relievers most frequently involved in these ED visits, whether the poisonings involved other drugs in addition to the opioid pain relievers, and the outcome of the visits.   The report also includes recommendations about preventing young children from being poisoned by opioid pain relievers.

Tags: accidental-ingestion, emergency-department-visits, pediatric-opioid-poisoning, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
2021 Mental Health Client-Level Data (MH-CLD) Detailed Tables

The Annual Detailed Tables provide data on race, ethnicity, sex, and age of clients served. The MH-CLD data set can also observe these demographic categories across National Outcome Measures (NOMs) which include stability in housing/residential status, adult employment, and access to services/capacity. These tables provide a comprehensive set of national, subgroup, and state-level data on key characteristics of individuals receiving treatment in the 2021 reporting year along with their mental health diagnoses and co-occurring disorders.

Tags: client-level-data, co-occurring-disorders, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Research Article: BMC Genetics

Background
          To date, in eukaryotes, ribosomal protein expression is known to be regulated at the transcriptional and/or translational levels. But other forms of regulation may be possible.
        
        
          Results
          Here, we report the successful tagging of functional ribosomal particles with a S7-GFP chimaeric protein, making it possible to observe in vivo ribosome dynamics in the filamentous fungus Podospora anserina. Microscopic observations revealed a novel kind of ribosomal protein regulation during the passage between cell growth and stationary phases, with a transient accumulation of ribosomal proteins and/or ribosome subunits in the nucleus, possibly the nucleolus, being observed at the beginning of stationary phase.
        
        
          Conclusion
          Nuclear sequestration can be another level of ribosomal protein regulation in eukaryotic cells.This may contribute to the regulation of cell growth and division.

Tags: nih, nuclear-sequestration, podospora-anserina, ribosomal-proteins, ribosome-dynamics
Organization: U.S. Department of Health & Human Services
2016 Uniform Reporting System (URS) Table for Indiana

This is the 2016 Uniform Reporting System (URS) Output Tables for Indiana. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-program, mental-health-services, national-outcome-measures, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
Child is Identified as a Special Needs Adoption: 10/1/2011 - 9/30/2012

This report provides state-specific data from fiscal year 2012 about whether an adoption through a public agency was identified as a special needs adoption.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: adoption, data, fiscal, need, policy
Organization: U.S. Department of Health & Human Services
Detroit: Drug-Related Emergency Department Visits, 2004-2011 - All Alcohol

Excel file with estimates, rates, relative standard errors, trends and confidence intervals, covering 2004-2011 for emergency department visits involving alcohol in the Detroit metropolitan area.  For adults aged 21 and older, the alcohol was found in combination with other drugs. For patients under the age of 21, the visit may involve alcohol alone or in combination with other drugs.File includes data for over 500 drugs, including illicit drugs, prescription and over-the-counter medications, dietary supplements, inhalants and alcohol.  Includes total visits, gender, age group, race/ethnicity, outcome of visit, drug combinations, number of drugs involved in visit, drug frequency, and drugs confirmed by toxicology.Additional detail is provided for illicit drugs, psychotherapeutic drugs, central nervous system (CNS) drugs, respiratory drugs and cardiovascular drugs.

Tags: alcohol-related-ed-visits, detroit-drug-overdose, emergency-department-data, samhsa, substance-abuse-trends
Organization: U.S. Department of Health & Human Services
2017 National Mental Health Services Survey (N-MHSS) State Profiles

These state profiles include data from facilities that reported to N-MHSS for the survey reference date April 30, 2017. The N-MHSS collects data on the location, characteristics, services offered, and number of clients (collected every other year) in treatment at mental health treatment facilities (public and private) throughout the 50 states, the District of Columbia, U.S. territories, and other jurisdictions.

Tags: behavioral-health, facility-characteristics, mental-health-services, samhsa, treatment-facilities
Organization: U.S. Department of Health & Human Services
Miami - Fort Lauderdale Div: Drug-Related Emergency Department Visits, 2008-2011 - Accidental Ingestions

Excel file with estimates, rates, relative standard errors, trends and confidence intervals, covering 2008-2011 for emergency department visits involving accidental ingestions in the Miami metropolitan are, Fort Lauderdale division. This analytic category includes ED visits in which an individual accidentally or unknowingly used or was administered a prescription drug, over-the-counter medication, or dietary supplement. Drug-related accidental ingestion typically involves patients aged 5 and under.  This analytic category does not include drug misuse or abuse.File includes data for over 500 drugs, including illicit drugs, prescription and over-the-counter medications, dietary supplements, inhalants and alcohol.  Includes total visits, gender, age group, race/ethnicity, outcome of visit, drug combinations, number of drugs involved in visit, drug frequency, and drugs confirmed by toxicology.Additional detail is provided for illicit drugs, psychotherapeutic drugs, central nervous system (CNS) drugs, respiratory drugs and cardiovascular drugs.

Tags: accidental-ingestion, drug-related-ed, emergency-department-visits, pediatric-poisoning, samhsa
Organization: U.S. Department of Health & Human Services
Children's Eyewitness Reports after Exposure to Misinformation from Parents, 1994-1995

This study examined how misleading suggestions from parents influenced children’s eyewitness reports. A sample of 114 children (3 to 8 years old) participated in science demonstrations, listened to their parents read a story that described experienced and nonexperienced events, and subsequently discussed the science experience in two follow-up interviews. Data include descriptive information on the participants and their families, condition assignments, and information about children’s responses to interview questions during each of the three experimental sessions. In Session 1, immediately after exposure to the science demonstrations, the children answered five open-ended questions about their experiences with "Mr. Science." In Session 2, conducted in the children’s homes approximately 3.5 months later and after parents read the misleading story, each child answered (a) the same five open-ended questions as in Session 1,  (b) a set of ten direct yes-no questions (each followed by a prompt to describe the event in question) and, (c) open-ended and direct questions that asked the child to report which events were described in the book and which events had really happened during their visit to Mr. Science (i.e., the source-monitoring procedure). Session 3 was a repetition of the Session 2 interview after a 1-month delay with no further intentional memory contamination.  Each child witnessed four science demonstrations (from a set of eight demonstrations). For each child, the misleading story described two science demonstrations that the child witnessed, two novel science demonstrations, and one of two descriptions of nonexperienced touching. Thus there are six within-subject event conditions for each child:  two demonstrations that were experienced but not described in the story (i.e., experienced only events), two demonstrations that were experienced and described in the story (i.e., experienced-heard events), two demonstrations that were described in the story but not experienced (i.e., heard-only events), two demonstrations that were neither experienced or described in the story (i.e., control events), one event involving nonexperienced touching that was described in the story (i.e., a touch-heard event), and one touching event that was not experienced or described in the story (i.e., a touch-control event).

Investigators: Poole, Debra; Lindsay, D. Stephen

Tags: abuse, care, ndacan, policy, reporting
Organization: U.S. Department of Health & Human Services
Title IV-E Programs Expenditure and Caseload Data 2022

The Children’s Bureau posts an annual FY summary of Form CB-496 expenditures and caseloads as reported by each title IV-E agency. These data tables include the combination of current-quarter and prior-quarter adjustment expenditures and current-quarter caseload data as delineated in quarterly Form CB-496 submissions for FY 2022.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: child, policy, real, reporting, time
Organization: U.S. Department of Health & Human Services
Compound 525094: 1,3-Dichloroisopropyl butyrate

Chemical compound data from PubChem database. IUPAC Name: 1,2-dichloropropan-2-yl butanoate. Molecular Formula: C7H12Cl2O2. Molecular Weight: 199.07. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services