AndreaBozzo/ceres-open-data-index huggingface dataset:
Publications Using SAMHSA DataNorth Dakota 2016 Potential Areas for Addressing Service Gaps for Opioid Treatment

The purpose of the medication-assisted treatment (MAT) facility maps is to identify areas on a state-by-state basis that may be potentially underserved by existing treatment facilities. The maps are created with a methodology that seeks to include the highest potential need areas from individual counties so that county-level stakeholders are also informed. The maps are meant to be used as a tool for policy makers to determine potentially underserved areas—not as a definitive representation of these areas.

Tags: medication-assisted-treatment, north-dakota, opioid-treatment, samhsa, service-gap-analysis
Organization: U.S. Department of Health & Human Services
Compound 525662: p-Bromobenzylidene-(4-methoxyphenyl)-amine

Chemical compound data from PubChem database. IUPAC Name: 1-(4-bromophenyl)-N-(4-methoxyphenyl)methanimine. Molecular Formula: C14H12BrNO. Molecular Weight: 290.15. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Publications Using SAMHSA Data2021 Uniform Reporting System (URS) Table For Nebraska

This is the 2021 Uniform Reporting System (URS) Output Tables for Nebraska. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-data, mental-health-services, national-outcome-measures, nebraska-urs, samhsa
Organization: U.S. Department of Health & Human Services
National Survey on Drug Use and Health:  2014 and 2015 Redesign Changes

This report describes changes in the 2014 and 2015 NSDUHs that were designed to increase the efficiency of data collection and processing and to improve the quality of the data collected. In 2014, changes were made in the sample sizes allocated to each state and to different age groups in order to increase the precision of national and many state estimates as well as estimates for older adults. In 2015, changes were made to the survey questionnaire to improve the quality of the data collected, expand the number of prescription drugs covered, and address changing substance use and mental health policy and research needs. New data collection equipment was introduced in 2015 to replace the older equipment in the field. Respondent materials also were updated. This report provides information on the key changes made as well as some of the potential implications for data users.

Tags: data-collection-methods, mental-health-survey, nsduh-redesign, samhsa, substance-use-survey
Organization: U.S. Department of Health & Human Services
Debate: "How low should LDL cholesterol be lowered for optimum prevention of vascular disease?" Viewpoint: "Below 100 mg/dl"

Arteriosclerotic vascular disease manifests as heart disease, stroke, aortic aneurysms, and peripheral vascular disease, and is a growing problem world-wide. The preventive efforts made so far have demonstrated that lowering LDL-C is one action that individuals and populations can do with significant success in delaying the onset of clinical events. Epidemiological studies and small clinical trials suggest that more aggressive and sustained lowering to LDL-C below 100 mg/dl could result in 50 to 70% reductions in vascular death. The full benefit of reducing LDL-C is only now being tested in adequate clinical trials.

Tags: arteriosclerosis, cholesterol-lowering, ldl-cholesterol, nih, vascular-disease
Organization: U.S. Department of Health & Human Services
Mouse skin passage of a Streptococcus pyogenes Tn917 mutant of sagA/pel restores virulence, beta-hemolysis and sagA/pel expression without altering the position or sequence of the transposon: Correction

Mouse skin passage of a Streptococcus pyogenes Tn917 mutant of sagA/pel restores virulence, beta-hemolysis and sagA/pel expression without altering the position or sequence of the transposon: Correction

Tags: genetic-mutation, mouse-model, nih, streptococcus-pyogenes, virulence-factors
Organization: U.S. Department of Health & Human Services
Dose response of ACE inhibitors: implications of the SECURE trial

The choice of the appropriate dosage of ACE inhibitor in clinical practice is an important one. The available evidence suggests that in chronic heart failure as well as in chronic coronary artery disease, high doses of angiotensin-converting enzyme (ACE) inhibitor are more effective than low ones. The current recommended clinical approach is to target ACE inhibitor dosing regimens to be similar to those used in the clinical trials, which demonstrated mortality and morbidity benefits. When titrated appropriately, ACE inhibitors are generally well tolerated and target doses can be achieved and maintained in the majority of patients with atherosclerotic vascular disease, with or without heart failure.

Tags: ace-inhibitors, coronary-disease, dose-response, heart-failure, nih
Organization: U.S. Department of Health & Human Services
Laparoscopic and open surgery for pheochromocytoma

Backround
          Laparoscopic adrenalectomy is a promising alternative to open surgery although concerns exist in regard to laparoscopic treatment of pheocromocytoma. This report compares the outcome of laparoscopic and conventional (open) resection for pheocromocytoma particular in regard to intraoperative hemodynamic stability and postoperative patient comfort.
        
        
          Methods
          Seven patients laparoscopically treated (1997–2000) and nine patients treated by open resection (1990–1996) at the National Hospital (Rikshospitalet), Oslo. Peroperative hemodynamic stability including need of vasoactive drugs was studied. Postoperative analgesic medication, complications and hospital stay were recorded.
        
        
          Results
          No laparoscopic resections were converted to open procedure. Patients laparoscopically treated had fewer hypertensive episodes (median 1 vs. 2) and less need of vasoactive drugs peroperatively than patients conventionally operated. There was no difference in operative time between the two groups (median 110 min vs. 125 min for adrenal pheochromocytoma and 235 vs. 210 min for paraganglioma). Postoperative need of analgesic medication (1 vs. 9 patients) and hospital stay (median 3 vs. 6 days) were significantly reduced in patients laparoscopically operated compared to patients treated by the open technique.
        
        
          Conclusion
          Surgery for pheochromocytoma can be performed laparoscopically with a safety comparable to open resection. However, improved hemodynamic stability peroperatively and less need of postoperative analgesics favour the laparoscopic approach. In experienced hands the laparoscopic technique is concluded to be the method of choice also for pheocromocytoma.

Tags: hemodynamic-stability, laparoscopic-adrenalectomy, nih, pheochromocytoma, surgical-outcomes
Organization: U.S. Department of Health & Human Services
National Directory of Drug and Alcohol Abuse Treatment Facilities 2009

The National Directory of Drug and Alcohol Abuse Treatment Programs 2009 lists federal, state, local, and private facilities that provide substance abuse treatment services. The directory includes treatment facilities that are licensed, certified, or otherwise approved for inclusion in the directory by their state substance abuse agencies and that responded to the 2008 National Survey of Substance Abuse Treatment Services (N-SSATS). The information about each facility that appears in this directory was provided by that facility in response to the 2008 N-SSATS. The Substance Abuse and Mental Health Services Administration (SAMHSA) conducts the N-SSATS annually.

Tags: alcohol-abuse-treatment, n-ssats, samhsa, substance-abuse-treatment, treatment-facility-directory
Organization: U.S. Department of Health & Human Services
Chafee Independent Living Evaluation Project

Chafee Independent Living Evaluation Project identifies programs that can be rigorously evaluated and ultimately determines the effects of Independent Living Programs funded under CFCIP in achieving key outcomes for participating youth. This evaluation was called for in the Foster Care Independence Act of 1999.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: assessment, care, foster, policy, scope
Organization: U.S. Department of Health & Human Services
The neuropharmacology of upper airway motor control in the awake and asleep states: implications for obstructive sleep apnoea

Obstructive sleep apnoea is a common and serious breathing problem that is caused by effects of sleep on pharyngeal muscle tone in individuals with narrow upper airways. There has been increasing focus on delineating the brain mechanisms that modulate pharyngeal muscle activity in the awake and asleep states in order to understand the pathogenesis of obstructive apnoeas and to develop novel neurochemical treatments. Although initial clinical studies have met with only limited success, it is proposed that more rational and realistic approaches may be devised for neurochemical modulation of pharyngeal muscle tone as the relevant neurotransmitters and receptors that are involved in sleep-dependent modulation are identified following basic experiments.

Tags: neuropharmacology, nih, obstructive-sleep-apnea, pharyngeal-muscle-tone, upper-airway-control
Organization: U.S. Department of Health & Human Services
National Mental Health Services Survey (N-MHSS): 2016, Data On Mental Health Treatment Facilities

This report presents findings from the 2016 National Mental Health Services Survey (N-MHSS) conducted from March 2016 through January 2017. The N-MHSS collects information from all known facilities in the United States, both public and private, that provide mental health treatment services to people with mental illness.  The Center for Behavioral Health Statistics and Quality(CBHSQ) of the Substance Abuse and Mental Health Services Administration (SAMHSA), U.S.Department of Health and Human Services, plans and directs the N-MHSS.

Tags: behavioral-health, mental-health-services, mental-illness, samhsa, treatment-facilities
Organization: U.S. Department of Health & Human Services
Residence of individuals experiencing homelessness prior to enrollment in Projects for Assistance in Transition from Homelessness (PATH) program: Findings from the 2023 PATH Evaluation

This spotlight highlights a notable finding from the evaluation of SAMHSA’s Projects for Assistance in Transition from Homelessness (PATH) program published in 2024. The PATH program is intended to reduce homelessness among persons experiencing severe mental illness or co-occurring mental illness and substance use disorders. PATH collects data on the reported residence of clients the night prior to enrolling in services. An examination of these data for FY 2019 to 2021 revealed an approximately ten-point percentage increase of PATH clients reporting being in an unsheltered situation the night prior to enrollment.

Tags: homelessness, mental-illness, path-program, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Functional evolution of two subtly different (similar) folds

Background
          The function of proteins is a direct consequence of their three-dimensional structure. The structural classification of proteins describes the ways of folding patterns all proteins could adopt. Although, the protein folds were described in many ways the functional properties of individual folds were not studied.
        
        
          Results
          We have analyzed two β-barrel folds generally adopted by small proteins to be looking similar but have different topology. On the basis of the topology they could be divided into two different folds named SH3-fold and OB-fold. There was no sequence homology between any of the proteins considered. The sequence diversity and loop variability was found to be important for various binding functions.
        
        
          Conclusions
          The function of Oligonucleotide/oligosaccharide-binding (OB) fold proteins was restricted to either DNA/RNA binding or sugar binding whereas the Src homology 3 (SH3) domain like proteins bind to a variety of ligands through loop modulations. A question was raised whether the evolution of these two folds was through DNA shuffling.

Tags: nih, ob-fold, protein-folding, protein-structure, sh3-domain
Organization: U.S. Department of Health & Human Services
Compound 527393: 4-Mercapto-2-pentanone

Chemical compound data from PubChem database. IUPAC Name: 4-sulfanylpentan-2-one. Molecular Formula: C5H10OS. Molecular Weight: 118.2. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2014 CMHS Uniform Reporting System (URS) Table for West Virginia

2014 Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for West Virginia. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant, mental-health-services, outcome-measures, samhsa, west-virginia
Organization: U.S. Department of Health & Human Services
2012 Sample Design Report

This report describes the sample design to the 2012 National Survey on Drug Use and Health (NSDUH). A coordinated sample design was developed for the 2005 through 2009 NSDUHs. The 2010-2011 and 2012-2013 samples are extensions of the 5-year sample. This report describes the general sample allocation procedures for the main NSDUH study, the NSDUH\'s Mental Health Surveillance Study, and the Questionnaire Field Test.

Tags: drug-use, mental-health-surveillance, nsduh, samhsa, sample-design
Organization: U.S. Department of Health & Human Services
Differential clinical efficacy of anti-CD4 monoclonal antibodies in rat adjuvant arthritis is paralleled by differential influence on NF-κB binding activity and TNF-α secretion of T cells

The aim of this study was to analyze the differential effects of three anti-CD4 monoclonal antibodies (mAbs) (with distinct epitope specifities) in the treatment of rat adjuvant arthritis (AA) and on T-cell function and signal transduction. Rat AA was preventively treated by intraperitoneal injection of the anti-CD4 mAbs W3/25, OX35, and RIB5/2 (on days -1, 0, 3, and 6, i.e. 1 day before AA induction, on the day of induction [day 0], and thereafter). The effects on T-cell reactivity in vivo (delayed-type hypersensitivity), ex vivo (ConA-induced proliferation), and in vitro (mixed lymphocyte culture) were assessed. The in vitro effects of anti-CD4 preincubation on T-cell receptor (TCR)/CD3-induced cytokine production and signal transduction were also analyzed. While preventive treatment with OX35 and W3/25 significantly ameliorated AA from the onset, treatment with RIB5/2 even accelerated the onset of AA by approximately 2 days (day 10), and ameliorated the arthritis only in the late phase (day 27). Differential clinical effects at the onset of AA were paralleled by a differential influence of the mAbs on T-cell functions, i.e. in comparison with OX35 and W3/25, the 'accelerating' mAb RIB5/2 failed to increase the delayed-type hypersentivity (DTH) to Mycobacterium tuberculosis, increased the in vitro tumor necrosis factor (TNF)-α secretion, and more strongly induced NF-κB binding activity after anti-CD4 preincubation and subsequent TCR/CD3-stimulation. Depending on their epitope specificity, different anti-CD4 mAbs differentially influence individual proinflammatory functions of T cells. This fine regulation may explain the differential efficacy in the treatment of AA and may contribute to the understanding of such treatments in other immunopathologies.

Tags: adjuvant-arthritis, anti-cd4-antibodies, nf-kappab-binding, nih, tnf-alpha-secretion
Organization: U.S. Department of Health & Human Services
National Directory of Drug Abuse Treatment Facilities - 1980

The National Directory of Drug Abuse Treatment Programs 1980 lists federal, state, local, and private facilities that provide substance abuse treatment services. The directory includes treatment facilities that are licensed, certified, or otherwise approved for inclusion in the directory by their state substance abuse agencies and that responded to the 1979 National Survey of Substance Abuse Treatment Services (N-SSATS). The information about each facility that appears in this directory was provided by that facility in response to the 1979 N-SSATS. The Substance Abuse and Mental Health Services Administration (SAMHSA) conducts the N-SSATS annually.

Tags: drug-abuse-treatment, n-ssats, samhsa, substance-abuse, treatment-facilities
Organization: U.S. Department of Health & Human Services
Insight to structural subsite recognition in plant thiol protease-inhibitor complexes : Understanding the basis of differential inhibition and the role of water

Background
          This work represents an extensive MD simulation / water-dynamics studies on a series of complexes of inhibitors (leupeptin, E-64, E-64-C, ZPACK) and plant cysteine proteases (actinidin, caricain, chymopapain, calotropin DI) of papain family to understand the various interactions, water binding mode, factors influencing it and the structural basis of differential inhibition.
        
        
          Results
          The tertiary structure of the enzyme-inhibitor complexes were built by visual interactive modeling and energy minimization followed by dynamic simulation of 120 ps in water environment. DASA study with and without the inhibitor revealed the potential subsite residues involved in inhibition. Though the interaction involving main chain atoms are similar, critical inspection of the complexes reveal significant differences in the side chain interactions in S2-P2 and S3-P3 pairs due to sequence differences in the equivalent positions of respective subsites leading to differential inhibition.
        
        
          Conclusion
          The key finding of the study is a conserved site of a water molecule near oxyanion hole of the enzyme active site, which is found in all the modeled complexes and in most crystal structures of papain family either native or complexed. Conserved water molecules at the ligand binding sites of these homologous proteins suggest the structural importance of the water, which changes the conventional definition of chemical geometry of inhibitor binding domain, its shape and complimentarity. The water mediated recognition of inhibitor to enzyme subsites (Pn...H2O....Sn) of leupeptin acetyl oxygen to caricain, chymopapain and calotropinDI is an additional information and offer valuable insight to potent inhibitor design.

Tags: cysteine-proteases, enzyme-inhibitor-complexes, molecular-dynamics-simulation, nih, protein-inhibitor-interactions
Organization: U.S. Department of Health & Human Services
Kansas 2016 Potential Areas for Addressing Service Gaps for Opioid Treatment

The purpose of the medication-assisted treatment (MAT) facility maps is to identify areas on a state-by-state basis that may be potentially underserved by existing treatment facilities. The maps are created with a methodology that seeks to include the highest potential need areas from individual counties so that county-level stakeholders are also informed. The maps are meant to be used as a tool for policy makers to determine potentially underserved areas—not as a definitive representation of these areas.

Tags: kansas-opioids, medication-assisted-treatment, opioid-treatment, samhsa, service-gap-analysis
Organization: U.S. Department of Health & Human Services
Impact of nosocomial pneumonia on the outcome of mechanically-ventilated patients

Background:
          Nosocomial pneumonia (NP) is a common complication in mechanically-ventilated patients and is considered to be one of the most common causes of morbidity and mortality. However, assessment of the associated mortality is not staightforward as it shares several risk factors with NP that confound the relationship. The aim of this study was to evaluate the impact of NP on the mortality rate in an intensive care unit. During the study period (January-December 1995) all patients under mechanical ventilation for a period > 48 h (n = 314) were prospectively evaluated, and the prognostic factors of NP, which have been identified in previous studies, were recorded.
        
        
          Results:
          Pneumonia was diagnosed in 82 patients. The overall mortality rate was 34% for patients with NP compared to 17% in those without NP. Multivariate analysis selected the following three prognostic factors as being significantly associated with a higher risk of death: the presence of multiple organ failure [odds ratio (OR) 6.71, 95% CI, P < 0.001]; the presence of adult respiratory distress syndrome (ARDS) (OR 3.03, 95% CI, P < 0.01), and simplified acute physiology score (SAPS)> 9(OR 2.89, 95% CI, P < 0.05).
        
        
          Conclusions:
          In mechanically-ventilated patients NP does not represent an independent risk factor for mortality. Markers of severity of illness were the strongest predictors for mortality.

Tags: icu-mortality, mechanical-ventilation, nih, nosocomial-pneumonia, ventilator-associated-pneumonia
Organization: U.S. Department of Health & Human Services
Enzyme replacement reverses abnormal cerebrovascular responses in Fabry disease

Background
          Fabry disease is a lysosomal X-linked enzyme deficiency of α-galactosidase A associated with an increased mortality and morbidity due to renal failure, cardiac disease and early onset stroke.
        
        
          Methods
          We examined the functional blood flow response of the brain after visual stimulation (reversing checkerboard pattern), and cerebral vasoreactivity following acetazolamide (15 mg/kg) with [15O]H2O and positron emission tomography (PET) in Fabry disease. Twenty-six hemizygous patients (age range 19–47 years) were enrolled in a randomized double-blind placebo-controlled 6-month trial of enzyme replacement therapy administered by intravenous infusion every two weeks. Regional cerebral blood flow (rCBF) was measured with PET at the beginning and end of the trial.
        
        
          Results
          Fabry patients had a significantly greater increase in rCBF following visual stimulation and acetazolamide challenge compared to controls. Visual reactivity was normal. The time for recovery of the cerebral vasculature following acetazolamide was prolonged in Fabry patients compared to controls. The abnormal rCBF response induced by visual stimulation and acetazolamide decreased significantly following enzyme replacement therapy, as did the prolonged recovery of the cerebral vasculature.
        
        
          Conclusions
          Enzyme replacement therapy reverses the exaggerated cerebrovascular response in Fabry disease.

Tags: cerebrovascular-response, enzyme-replacement-therapy, fabry-disease, nih, positron-emission-tomography
Organization: U.S. Department of Health & Human Services