AndreaBozzo/ceres-open-data-index huggingface dataset:
The enhancement of the hyperglycemic effect of S-nitrosoglutathione and S-nitroso-N-acetylpenicillamine by vitamin C in an animal model

Background
          S-nitrosoglutathione (GSNO) and S-nitroso-N-acetlypenicillamine (SNAP) are two of the most common sources of nitric oxide (NO) in the biomedical field. Vitamin C has been known to accelerate the decomposition of GSNO and SNAP increasing the release and availability of NO which is cytotoxic at non-physiological concentrations. The study investigates any potential detrimental effect of vitamin C and GSNO, vitamin C and SNAP on glucose metabolism in normotensive and normoglycemic dogs.
        
        
          Results
          The results showed that administration of vitamin C (50 mg/kg) and GSNO (35 mg/kg & 50 mg/kg), or vitamin C (50 mg/kg) and SNAP (10 mg/kg) to overnight fasted dogs resulted in significant elevation of the blood glucose levels, attaining maximum level at the 2.0 or 2.5 h time point postprandially. The elevated blood glucose levels were due to significant reduction in plasma insulin levels in the dogs treated with vitamin C and GSNO, or vitamin C and SNAP (P < 0.05). The decreased insulin response was associated with significant elevation of nitric oxide produced from GSNO and SNAP co-administered with vitamin C, as assessed by plasma nitrate/nitrite levels.
        
        
          Conclusions
          The results indicate that enhanced NO release by vitamin C affects postprandial blood glucose and plasma insulin levels and the reduced glucose tolerance is mainly due to impaired insulin release. The clinical relevance of the findings of this study suggest that hypertensive diabetic patients treated with GSNO or SNAP, who are on vitamin C supplements may be more predisposed to further decrease in their glycemic control.

Tags: glucose-metabolism, hyperglycemia, nih, s-nitrosoglutathione, vitamin-c
Organization: U.S. Department of Health & Human Services
Adoption Excellence Awards

The Adoption Excellence Awards recognize outstanding accomplishments in achieving permanency for America's children waiting in foster care. An annual program that grew out of the Adoption and Safe Families Act of 1997, these awards honor States, local agencies, private organizations, courts, businesses, individuals, and families making key contributions to increasing the number of children from foster care who are adopted or placed in other permanent homes.

To obtain a nomination packet for the 2024 Adoption Excellence Awards, please visit this page
  
  

.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: adoption, care, foster, grant, policy
Organization: U.S. Department of Health & Human Services
Mental Health Client-Level Data (MH-CLD) 2021: Data On Clients Receiving Mental Health Treatment Services Through State Mental Health Agencies

This report describes the total number of clients receiving mental health treatment services in 2021 by demographics, National Outcome Measures (NOMs) and the top five mental health diagnoses for children (ages 0 - 17) and adults (18 and older) by geographical distribution. The NOMs presented in this report include stability in housing/residential status, adult employment, and access to services/capacity.

Tags: client-level-data, mental-health-diagnoses, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Compound 528348: Phenol, 2,6-dichloro, TMS

Chemical compound data from PubChem database. IUPAC Name: (2,6-dichlorophenoxy)-trimethylsilane. Molecular Formula: C9H12Cl2OSi. Molecular Weight: 235.18. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Trends in Smokeless Tobacco Use and Initiation: 2002 to 2012

This short report uses 2002 to 2012 National Survey on Drug Use and Health (NSDUH) to assess trends in past month smokeless tobacco initiation and use by gender and age group among those aged 12 or older.

Tags: nsduh-data, samhsa, smokeless-tobacco, substance-use, tobacco-initiation
Organization: U.S. Department of Health & Human Services
Compound 525169: Hexapropylene glycol, monoallyl ether, acetate

Chemical compound data from PubChem database. IUPAC Name: 1-[1-[1-[1-[1-(1-prop-2-enoxypropan-2-yloxy)propan-2-yloxy]propan-2-yloxy]propan-2-yloxy]propan-2-yloxy]propan-2-yl acetate. Molecular Formula: C23H44O8. Molecular Weight: 448.6. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 525128: 2,3,4-Trimethoxy-6-(methoxymethyl)-5-[3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxyoxane

Chemical compound data from PubChem database. IUPAC Name: 2,3,4-trimethoxy-6-(methoxymethyl)-5-[3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxyoxane. Molecular Formula: C20H38O11. Molecular Weight: 454.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Louisiana (LA)

This report presents Louisiana\'s estimates for 25 measures of substance use and mental health based on the combined 2009 and 2010 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for Louisiana for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: louisiana, mental-health, nsduh-data, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Compound 525385: 2,5-Dithiaheptane

Chemical compound data from PubChem database. IUPAC Name: 1-ethylsulfanyl-2-methylsulfanylethane. Molecular Formula: C5H12S2. Molecular Weight: 136.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2015 CMHS Uniform Reporting System (URS) Table for Virginia

2015 Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for Virginia. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, national-outcome-measures, samhsa, virginia
Organization: U.S. Department of Health & Human Services
The methionine salvage pathway in

Background
          Polyamine synthesis produces methylthioadenosine, which has to be disposed of. The cell recycles it into methionine through methylthioribose (MTR). Very little was known about MTR recycling for methionine salvage in Bacillus subtilis.
        
        
          Results
          Using in silico genome analysis and transposon mutagenesis in B. subtilis we have experimentally uncovered the major steps of the dioxygen-dependent methionine salvage pathway, which, although similar to that found in Klebsiella pneumoniae, recruited for its implementation some entirely different proteins. The promoters of the genes have been identified by primer extension, and gene expression was analyzed by Northern blotting and lacZ reporter gene expression. Among the most remarkable discoveries in this pathway is the role of an analog of ribulose diphosphate carboxylase (Rubisco, the plant enzyme used in the Calvin cycle which recovers carbon dioxide from the atmosphere) as a major step in MTR recycling.
        
        
          Conclusions
          A complete methionine salvage pathway exists in B. subtilis. This pathway is chemically similar to that in K. pneumoniae, but recruited different proteins to this purpose. In particular, a paralogue or Rubisco, MtnW, is used at one of the steps in the pathway. A major observation is that in the absence of MtnW, MTR becomes extremely toxic to the cell, opening an unexpected target for new antimicrobial drugs. In addition to methionine salvage, this pathway protects B. subtilis against dioxygen produced by its natural biotope, the surface of leaves (phylloplane).

Tags: bacillus-subtilis, methionine-salvage, mtr-recycling, nih, polyamine-synthesis
Organization: U.S. Department of Health & Human Services
The human homologue of

Background
          In sporadic ovarian cancer, we have previously reported allele loss at D6S193 (62%) on chromosome 6q27, which suggested the presence of a putative tumour suppressor gene. Based on our data and that from another group, the minimal region of allele loss was between D6S264 and D6S149 (7.4 cM). To identify the putative tumour suppressor gene, we established a physical map initially with YACs and subsequently with PACs/BACs from D6S264 to D6S149. To accelerate the identification of genes, we sequenced the entire contig of approximately 1.1 Mb. Seven genes were identified within the region of allele loss between D6S264 and D6S149.
        
        
          Results
          The human homologue of unc-93 (UNC93A) in C. elegans was identified to be within the interval of allele loss centromeric to D6S149. This gene is 24.5 kb and comprises of 8 exons. There are two transcripts with the shorter one due to splicing out of exon 4. It is expressed in testis, small intestine, spleen, prostate, and ovary. In a panel of 8 ovarian cancer cell lines, UNC93A expression was detected by RT-PCR which identified the two transcripts in 2/8 cell lines. The entire coding sequence was examined for mutations in a panel of ovarian tumours and ovarian cancer cell lines. Mutations were identified in exons 1, 3, 4, 5, 6 and 8. Only 3 mutations were identified specifically in the tumour. These included a c.452G>A (W151X) mutation in exon 3, c.676C>T (R226X) in exon 5 and c.1225G>A(V409I) mutation in exon 8. However, the mutations in exon 3 and 5 were also present in 6% and 2% of the normal population respectively. The UNC93A cDNA was shown to express at the cell membrane and encodes for a protein of 60 kDa.
        
        
          Conclusions
          These results suggest that no evidence for UNC93A as a tumour suppressor gene in sporadic ovarian cancer has been identified and further research is required to evaluate its normal function and role in the pathogenesis of ovarian cancer.

Tags: gene-mapping, nih, ovarian-cancer, tumor-suppressor-gene, unc-93-homologue
Organization: U.S. Department of Health & Human Services
Illicit Drug Use Tables (Standard Errors and P Values) - 1.1 to 1.92

These detailed tables present standard errors for illicit drug use totals and prevalence estimates from the 2010 National Survey on Drug Use and Health (NSDUH). Illicit drugs include marijuana, cocaine, crack, heroin, hallucinogens, inhalants, and the nonmedical use of prescription-type psychotherapeutics, including pain relievers, tranquilizers, stimulants, and sedatives. Standard errors are provided for lifetime, past year, and past month use by age group, gender, race/ethnicity, education level, employment status, and geographic area. Standard errors are provided for both 2010 and 2009.

Tags: drug-prevalence, illicit-drug-use, nsduh-survey, samhsa, standard-errors
Organization: U.S. Department of Health & Human Services
4.23 Facilities using counseling as part of their substance abuse treatment program, by primary focus of facility: March 31, 2010. Number

This is a National Survey of Substance Abuse Treatment Services (N-SSATS) data table showing facilities using counseling as part of their substance abuse treatment program, by primary focus of facility in 2011. N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 States, the District of Columbia, and other U.S. jurisdictions.

Tags: counseling-services, n-ssats, samhsa, substance-abuse-treatment, treatment-facilities
Organization: U.S. Department of Health & Human Services
Compound 528354: Adamantane, 2-(1-pyrrolyl)

Chemical compound data from PubChem database. IUPAC Name: 1-(2-adamantyl)pyrrole. Molecular Formula: C14H19N. Molecular Weight: 201.31. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2012 State Profile - Arizona

This is a National Survey of Substance Abuse Treatment Services (N-SSATS) annual report showing the state profile for Arizona in 2012. N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 States, the District of Columbia, and other U.S. jurisdictions.

Tags: arizona, n-ssats, samhsa, substance-abuse-treatment, treatment-facilities
Organization: U.S. Department of Health & Human Services
A Comparative Study of the Use and Effectiveness of Different Risk Assessment Models in CPS Decision Making Processes

Three risk assessment models will be evaluated, using data collected on cases from three sites.  In addition to the primary study of objectives of assessing reliability and validity of existing risk assessment models, the researchers will use the data collected to develop the optimal risk instrument for each site and for all sites combined.  Investigators will use statistical analyses to determine the influence of various agency and worker factors on outcomes. Cultural differences will be given special emphasis.  Sites will be chosen to ensure numbers sufficient to analyze system model performance with African Americans, Hispanics, and Caucasians.  Researchers will make an effort to obtain a significant American Indian population.

Investigators: Baird, Christopher

Tags: abuse, care, ndacan, policy, reporting
Organization: U.S. Department of Health & Human Services
'CFTR-opathies': disease phenotypes associated with cystic fibrosis transmembrane regulator gene mutations

Cystic fibrosis is a genetic disease that is associated with abnormal sweat electrolytes, sino-pulmonary disease, exocrine pancreatic insufficiency, and male infertility. Insights into genotype/phenotype relations have recently been gained in this disorder. The strongest relationship exists between 'severe' mutations in the gene that encodes the cystic fibrosis transmembrane regulator (CFTR) and pancreatic insufficiency. The relationship between 'mild' mutations, associated with residual CFTR function, and expression of disease is less precise. Atypical 'mild' mutations in the CFTR gene have been linked to late-onset pulmonary disease, congenital bilateral absence of the vas deferens, and idiopathic pancreatitis. Less commonly, sinusitis, allergic bronchopulmonary aspergillosis, and possibly even asthma may also be associated with mutations in the CFTR gene, but those syndromes predominantly reflect non-CFTR gene modifiers and environmental influences.

Tags: cftr-mutation, cystic-fibrosis, nih, pancreatic-insufficiency, phenotype-genotype
Organization: U.S. Department of Health & Human Services
Housing’s Critical Connection to Child Welfare — Part 2

This Child Welfare Information Gateway Podcast is available on Apple Podcasts
  
  

, GooglePlay
  
  

, Spotify
  
  

, Stitcher
  
  

, SoundCloud
  
  

, and the Child Welfare Information Gateway
  
  

 website. Subscribe to receive new episodes as they are released.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: child, housing, policy, sery, social
Organization: U.S. Department of Health & Human Services
Miscellaneous Tables (Standard Errors and P Values) - 6.1 to 6.107

These detailed tables present the standard errors for the totals and prevalence estimates of the number of days and types of substance use, poly-drug use, nicotine dependence, substance dependence by age of first use, source of substances, social context of substance use, and drunk/drugged driving from the 2010 National Survey on Drug Use and Health (NSDUH). Substances examined include illicit drugs, marijuana, cocaine, heroin, hallucinogens, inhalants, and the nonmedical use of prescription-type pain relievers, tranquilizers, stimulants, and sedatives, and alcohol. Standard errors are provided for totals and prevalence estimates of lifetime, past year, and past month use by age group, gender, race/ethnicity, education level, employment status, geographic area, pregnancy status, college enrollment status, and probation/parole status. Comparisons are made between 2010 and 2009.

Tags: drug-dependence, nsduh-2010, samhsa, standard-errors, substance-use
Organization: U.S. Department of Health & Human Services
Developmental Victimization Survey (DVS), 2002-2003

The Developmental Victimization Survey (DVS), was designed to obtain one-year incidence estimates of a comprehensive range of childhood victimizations across gender, race, and developmental stage.  Conducted between December 2002, and February 2003, it assessed the experiences of a nationally representative sample of children age 2-17 living in the contiguous United States.The sample selection procedures were based on a list-assisted random digit dial (RDD) telephone survey design. A short interview was conducted with an adult caregiver (usually a parent) to obtain family demographic information.  One child was randomly selected from all eligible children living in a household by selecting the child with the most recent birthday.  If the selected child was 10-17 years old, the main telephone interview was conducted with the child.  If the selected child was 2-9 years old, the interview was conducted with the caregiver who “is most familiar with the child’s daily routine and experiences.”  Interviews were completed with 79.5% of the eligible persons contacted.  All procedures were authorized by the Institutional Review Board of the University of New Hampshire.This survey utilized the Juvenile Victimization Questionnaire (JVQ), a recently constructed inventory of childhood victimization. The JVQ obtains reports on 34 forms of offenses against youth that cover five general areas of concern: Conventional Crime, Child Maltreatment, Peer and Sibling Victimization, Sexual Assault, and Witnessing and Indirect Victimization.  Follow-up questions for each screener item gathered additional information, including perpetrator characteristics, the use of a weapon, whether injury resulted, and whether the event occurred in conjunction with another screener.  The final sample represented 2,030 children age 2-17 living in the contiguous United States.  Half (50%) of the sample is male; 51% are 2-9 year olds, while 49% are age 10-17.  Almost 10% of the sample reported a household income of under $20,000, while about 34% had annual incomes between $20,000 and $50,000.  The survey sample is 76% White (non-Hispanic), 11% Black (non-Hispanic), 9% Hispanic (any race) and 3.5% from other races including American Indian and Asian.

Investigators: Heather Turner
University of New Hampshire Durham, NH

David Finkelhor, Ph.D.
University of New Hampshire Durham, NH

Tags: abuse, care, ndacan, policy, reporting
Organization: U.S. Department of Health & Human Services
Compound 525374: 2,4-Dimethyl-3,5-dithiahexane

Chemical compound data from PubChem database. IUPAC Name: 2-(1-methylsulfanylethylsulfanyl)propane. Molecular Formula: C6H14S2. Molecular Weight: 150.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2010 State Profile — Missouri

This state profile includes data from facilities in Missouri that reported to N-SSATS for the survey reference date March 31, 2010. Data were collected on the location, characteristics, services offered, and number of clients in treatment at alcohol and drug abuse treatment facilities (both public and private) in Missouri. In Missouri, 264 substance abuse treatment facilities were included in the 2010 N-SSATS, reporting that there were 19,766 clients in substance abuse treatment on March 31, 2010. The survey response rate in Missouri was 95.1%.

Tags: alcohol-drug-abuse, missouri, n-ssats, samhsa, substance-abuse-treatment
Organization: U.S. Department of Health & Human Services
Compound 527379: 21,27-Dimethylnonacosanenitrile

Chemical compound data from PubChem database. IUPAC Name: 21,27-dimethylnonacosanenitrile. Molecular Formula: C31H61N. Molecular Weight: 447.8. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2017 Uniform Reporting System (URS) Table for Indiana

This is the 2017 Uniform Reporting System (URS) Output Tables for Indiana. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-program, mental-health-services, national-outcome-measures, samhsa, urs-data
Organization: U.S. Department of Health & Human Services
Compound 525515: Thiomethyl ester alpha-(methyl-thio)propionic acid

Chemical compound data from PubChem database. IUPAC Name: S-methyl 2-methylsulfanylpropanethioate. Molecular Formula: C5H10OS2. Molecular Weight: 150.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 528523: Hexadecane, 5-octyl

Chemical compound data from PubChem database. IUPAC Name: 9-butylicosane. Molecular Formula: C24H50. Molecular Weight: 338.7. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services