AndreaBozzo/ceres-open-data-index huggingface dataset:
2022 Uniform Reporting System (URS) Table For Pennsylvania

This is the 2022 Uniform Reporting System (URS) Output Tables for Pennsylvania. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, evidence-based-practices, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Rhode Island (RI)

This report presents Rhode Island\'s estimates for 25 measures of substance use and mental health based on the combined 2009 and 2010 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for Rhode Island for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: mental-health, nsduh, rhode-island, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Sample Size and Population Estimates Tables (Prevalence Estimates) - 8.1 to 8.13

These detailed tables show sample sizes and population estimates from the 2012 National Survey on Drug Use and Health (NSDUH). Samples sizes and population estimates are provided by age group, gender, race/ethnicity, education level, employment status, geographic area, pregnancy status, college enrollment status, and probation/parole status.

Tags: drug-use, mental-health, nsduh-2012, prevalence-estimates, samhsa
Organization: U.S. Department of Health & Human Services
Table 16. 2011-2012 NSDUH Alcohol Dependence or Abuse in the Past Year, by Age Group and State

Table 16. Alcohol Dependence or Abuse in the Past Year, by Age Group and State: Percentages, Annual Averages Based on 2011 and 2012 NSDUHs. Results are provided by State and for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: alcohol-abuse, alcohol-dependence, nsduh-data, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
2014-2015 NSDUH State Estimates of Substance Use and Mental Disorders

State estimates for 15 measures of substance use and mental disorders based on the combined 2014 and 2015 National Surveys on Drug Use and Health (NSDUHs) are provided. The NSDUH is an annual survey of the civilian, noninstutionalized population of the United States aged 12 years or older. State and regional estimates are based on a small area estimation (SAE) methodology in which state-level NSDUH data are combined with county and census block group/tract-level data from the state.

Tags: mental-disorders, nsduh-survey, samhsa, state-estimates, substance-use
Organization: U.S. Department of Health & Human Services
Guidance and instruction related to the Supporting Foster Youth and Families through the Pandemic Act

This Program Instruction (PI) provides instruction and guidance to title IV-B/ IV-E agencies and Court Improvement Program Grantees on actions required to address the Supporting Foster Youth and Families through the Pandemic Act which was enacted as Division X of P.L. 116-260, the Consolidated Appropriations Act, 2021.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: foster, grant, instruction, policy, response
Organization: U.S. Department of Health & Human Services
Compound 527392: 28-Methyl-triacontyl cyanide

Chemical compound data from PubChem database. IUPAC Name: 29-methylhentriacontanenitrile. Molecular Formula: C32H63N. Molecular Weight: 461.8. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2011 State Profile — Oklahoma

This is a National Survey of Substance Abuse Treatment Services (N-SSATS) data table showing state profiles for Oklahoma in 2011. N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 States, the District of Columbia, and other U.S. jurisdictions.

Tags: n-ssats, oklahoma, samhsa, substance-abuse-treatment, treatment-facilities
Organization: U.S. Department of Health & Human Services
Compound 525634: N,N-Dimethyl-N'-nonyl-benzamidine

Chemical compound data from PubChem database. IUPAC Name: N,N-dimethyl-N'-nonylbenzenecarboximidamide. Molecular Formula: C18H30N2. Molecular Weight: 274.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
4.14 Facilities with client outreach, by facility operation and primary focus of facility: 2011. Number and percent

This is a National Survey of Substance Abuse Treatment Services (N-SSATS) data table showing facilities with client outreach, by facility operation and primary focus of facility in 2011. N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 States, the District of Columbia, and other U.S. jurisdictions.

Tags: client-outreach, facility-characteristics, n-ssats, samhsa, substance-abuse-treatment
Organization: U.S. Department of Health & Human Services
Compound 527356: 16,20-Dimethyl-tritriacontyl cyanide

Chemical compound data from PubChem database. IUPAC Name: 17,21-dimethyltetratriacontanenitrile. Molecular Formula: C36H71N. Molecular Weight: 518.0. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Treatment Episode Data Set (TEDS): 2016 Admissions to and Discharges from Publicly-Funded Substance Use Treatment

This report presents national- and state-level data from the Treatment Episode Data Set (TEDS) for admissions and discharges occurring in 2016, and trend data from 2006 to 2016. It summarizes demographic information and the characteristics and outcomes of treatment for alcohol and/or drug use among clients aged 12 years and older in facilities that report to individual state administrative data systems. Data include treatment admissions and discharges that were received and processed through March 16, 2018.

Tags: alcohol-drug-use, samhsa, substance-use-treatment, teds-admissions, treatment-outcomes
Organization: U.S. Department of Health & Human Services
Maitotoxin-induced membrane blebbing and cell death in bovine aortic endothelial cells

Background
          Maitotoxin, a potent cytolytic agent, causes an increase in cytosolic free Ca2+ concentration ([Ca2+]i) via activation of Ca2+-permeable, non-selective cation channels (CaNSC). Channel activation is followed by formation of large endogenous pores that allow ethidium and propidium-based vital dyes to enter the cell. Although activation of these cytolytic/oncotic pores, or COP, precedes release of lactate dehydrogenase, an indication of oncotic cell death, the relationship between CaNSC, COP, membrane lysis, and the associated changes in cell morphology has not been clearly defined. In the present study, the effect maitotoxin on [Ca2+]i, vital dye uptake, lactate dehydrogenase release, and membrane blebbing was examined in bovine aortic endothelial cells.
        
        
          Results
          Maitotoxin produced a concentration-dependent increase in [Ca2+]i followed by a biphasic uptake of ethidium. Comparison of ethidium (Mw 314 Da), YO-PRO-1 (Mw 375 Da), and POPO-3 (Mw 715 Da) showed that the rate of dye uptake during the first phase was inversely proportional to molecular weight, whereas the second phase appeared to be all-or-nothing. The second phase of dye uptake correlated in time with the release of lactate dehydrogenase. Uptake of vital dyes at the single cell level, determined by time-lapse videomicroscopy, was also biphasic. The first phase was associated with formation of small membrane blebs, whereas the second phase was associated with dramatic bleb dilation.
        
        
          Conclusions
          These results suggest that maitotoxin-induced Ca2+ influx in bovine aortic endothelial cells is followed by activation of COP. COP formation is associated with controlled membrane blebbing which ultimately gives rise to uncontrolled bleb dilation, lactate dehydrogenase release, and oncotic cell death.

Tags: calcium-influx, endothelial-cells, maitotoxin-toxicity, membrane-blebbing, nih
Organization: U.S. Department of Health & Human Services
Possible modulatory effect of endogenous islet catecholamines on insulin secretion

Background
          The possible participation of endogenous islet catecholamines (CAs) in the control of insulin secretion was tested.
        
        
          Methods
          Glucose-induced insulin secretion was measured in the presence of 3-Iodo-L-Tyrosine (MIT), a specific inhibitor of tyrosine-hydroxylase activity, in fresh and precultured islets isolated from normal rats. Incubated islets were also used to measure CAs release in the presence of low and high glucose, and the effect of α2-(yohimbine [Y] and idazoxan [I]) and α1-adrenergic antagonists (prazosin [P] and terazosin [T]) upon insulin secretion elicited by high glucose.
        
        
          Results
          Fresh islets incubated with 16.7 mM glucose released significantly more insulin in the presence of 1 μM MIT (6.66 ± 0.39 vs 5.01 ± 0.43 ng/islet/h, p < 0.02), but did not affect significantly the insulin response to low glucose. A similar enhancing effect of MIT upon insulin secretion was obtained using precultured islets devoid of neural cells, but absolute values were lower than those from fresh islets, suggesting that MIT inhibits islet rather than neural tyrosine hydroxylase. CAs concentration in the incubation media of fresh isolated islets was significantly higher in the presence of 16.7 than 3.3 mM glucose: dopamine 1.67 ± 0.13 vs 0.69 ± 0.13 pg/islet/h, p < 0.001, and noradrenaline 1.25 ± 0.17 vs 0.49 ± 0.04 pg/islet/h, p < 0.02. Y and I enhanced the release of insulin elicited by 16.7 mM glucose while P and T decreased such secretion.
        
        
          Conclusion
          Our results suggest that islet-originated CAs directly modulate insulin release in a paracrine manner.

Tags: catecholamines, glucose-induced-insulin, insulin-secretion, islet-cells, nih
Organization: U.S. Department of Health & Human Services
Child and Family Services Review Technical Bulletin #1

This technical bulletin was used to guide the second round of the Child and Family Services Reviews (CFSRs) and to evaluated states' achievement of the goals outlined in the Program Improvement Plans (PIPs) developed after the first round of CFSRs.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: child, guidance, instruction, policy, reporting
Organization: U.S. Department of Health & Human Services
2023 National Directory of Drug and Alcohol Use Treatment Facilities

TheNational Directory of Drug and AlcoholUseTreatment Facilities - 2023is a listing of federal, state, and local government facilities and private facilities that provide substance use treatment services. It includes treatment facilities that (1) are licensed, certified, or otherwise approved for inclusion in the Directory by their State Substance Use Agencies, and (2) responded to the 2022 National Substance Use and Mental Health Services Survey (N-SUMHSS). The information about each facility that appears in this Directory was provided by that facility in response to the 2022 N-SUMHSS. The N-SUMHSS is conducted annually by the Substance Abuse and Mental Health Services Administration (SAMHSA). The 2023 Directory is available in PDF and Excel formats.The Directory is ordered alphabetically by state, by city within each state, and by facility name within each city. Each facility listing includes codes that represent the services offered and other features of the facility, including codes that indicate services for hearing impaired and non-English-speaking clients. Codes are defined in a key shown on pages v-x of the PDF file and as a separate tab on the Excel version. Please note services offered by a particular facility may change over time. It is suggested to verify the information in this Directory when contacting a facility.

Tags: alcohol-treatment, drug-treatment, samhsa, substance-use-treatment, treatment-facilities
Organization: U.S. Department of Health & Human Services
Teaching clinical informatics to third-year medical students: negative results from two controlled trials

Background
          Prior educational interventions to increase seeking evidence by medical students have been unsuccessful.
        
        
          Methods
          We report two quasirandomized controlled trials to increase seeking of medical evidence by third-year medical students. In the first trial (1997–1998), we placed computers in clinical locations and taught their use in a 6-hour course. Based on negative results, we created SUMSearch(TM), an Internet site that automates searching for medical evidence by simultaneous meta-searching of MEDLINE and other sites. In the second trial (1999–2000), we taught SUMSearch's use in a 5½-hour course. Both courses were taught during the medicine clerkship. For each trial, we surveyed the entire third-year class at 6 months, after half of the students had taken the course (intervention group). The students who had not received the intervention were the control group. We measured self-report of search frequency and satisfaction with search quality and speed.
        
        
          Results
          The proportion of all students who reported searching at least weekly for medical evidence significantly increased from 19% (1997–1998) to 42% (1999–2000). The proportion of all students who were satisfied with their search results increased significantly between study years. However, in neither study year did the interventions increase searching or satisfaction with results. Satisfaction with the speed of searching was 27% in 1999–2000. This did not increase between studies years and was not changed by the interventions.
        
        
          Conclusion
          None of our interventions affected searching habits. Even with automated searching, students report low satisfaction with search speed. We are concerned that students using current strategies for seeking medical evidence will be less likely to seek and appraise original studies when they enter medical practice and have less time.

Tags: clinical-informatics, evidence-based-medicine, medical-education, medical-students, nih
Organization: U.S. Department of Health & Human Services
National Estimates of Drug-Related Emergency Department Visits, 2004-2011 - Adverse Reactions

Excel file with national estimates, rates, relative standard errors, trends and confidence intervals, covering 2004-2011 for emergency department visits involving adverse reactions.  It includes ED visits in which an adverse health consequence (e.g., side effects or an allergic reaction) resulted when taking prescription drugs, over-the-counter medications, or dietary supplements as prescribed or recommended.  This analytic category does not include drug misuse or abuse.File includes data for over 500 drugs, including illicit drugs, prescription and over-the-counter medications, dietary supplements, inhalants and alcohol.  Includes total visits, gender, age group, race/ethnicity, outcome of visit, drug combinations, number of drugs involved in visit, drug frequency, and drugs confirmed by toxicology.Additional detail is provided for illicit drugs, psychotherapeutic drugs, central nervous system (CNS) drugs, respiratory drugs and cardiovascular drugs.

Tags: drug-adverse-events, emergency-department-visits, prescription-drug-reactions, samhsa, toxicology-confirmed-drugs
Organization: U.S. Department of Health & Human Services
The National Survey of Child and Adolescent Well-Being (NSCAW): Implications for Child Welfare Evaluations Video

The video The National Survey of Child and Adolescent Well-Being (NSCAW): Implications for Child Welfare Evaluations illustrates ways that the NSCAW can provide a meaningful comparison group for those interested in assessing child and adolescent well-being outcomes in their jurisdictions.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: assessment, child, cross, data, policy
Organization: U.S. Department of Health & Human Services
National Survey of Substance Abuse Treatment Services: State Profiles 2009

The 2009 National Survey of Substance Abuse Treatment Services (N-SSATS) is an annual survey of facilities providing substance abuse treatment. The N-SSATS, conducted by the Substance Abuse and Mental Health Services Administration (SAMHSA), is designed to collect data on the location, characteristics, services offered, and number of clients in treatment at alcohol and drug abuse facilities (both public and private) throughout the 50 states, the District of Columbia, and other U.S. jurisdictions.

Tags: addiction-services, n-ssats, samhsa, substance-abuse-treatment, treatment-facilities
Organization: U.S. Department of Health & Human Services
NSDUH 2024 Questionnaire

Browse the English in-person and web interview questionnaires for the 2024 National Survey on Drug Use and Health (NSDUH). The documents provide the exact questions given to respondents in their full context, along with the skip patterns that determined whether a person was asked a question or not. There is also information on which sections were interviewer administered when conducted in-person, and a section that summarizes changes made to the questionnaire for 2024.

Tags: behavioral-health-survey, mental-health, nsduh-questionnaire, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Collection of corneal impression cytology directly on a sterile glass slide for the detection of viral antigen: An inexpensive and simple technique for the diagnosis of HSV epithelial keratitis – A pilot study

Background
          Herpes simplex keratitis (HSK) is a sight threatening ocular infection and occurs worldwide. A prompt laboratory diagnosis is often very useful. Conventional virology techniques are often expensive and time consuming. We describe here a highly economical, simple, rapid and sensitive technique for the collection of impression cytology, for the laboratory diagnosis of HSK.
        
        
          Methods
          Fifteen patients with a clinical diagnosis of HSK (either dendritic or geographic ulcers) and five patients with other corneal infections (Mycotic keratitis, n = 3, Bacterial keratitis, n = 2) were included in the study. Corneal impression cytology specimens were collected using a sterile glass slide with polished edges instead of a membrane, by pressing the surface of one end of the slide firmly, but gently on the corneal lesion. Additionally, corneal scrapings were collected following the impression cytology procedure. Impression cytology and corneal scrapings were stained by an immunoperoxidase or immunofluorescence assay for the detection of HSV-1 antigen using a polyclonal antibody to HSV-1. Corneal scrapings were processed for viral cultures by employing a shell vial assay.
        
        
          Results
          This simple technique allowed the collection of adequate corneal epithelial cells for the detection of HSV-1 antigen in a majority of the patients. HSV-1 antigen was detected in 12/15 (80%) cases while virus was isolated from 5/15 (33.3%) patients with HSK. All the patients with a clinical diagnosis of HSK (n = 15) were confirmed by virological investigations (viral antigen detection and/or viral cultures). HSV-1 antigen was detected in the impression cytology smears and corneal scrapings in 11/15 (73.3%) and 12/15 (80%) of the patients, respectively (P = 1.00). None of the patients in the control group were positive for viral antigen or virus isolation. Minimal background staining was seen in impression cytology smears, while there was some background staining in corneal scrapings stained by the immunoassays.
        
        
          Conclusions
          Collection of impression cytology on a sterile glass slide is a simple, rapid and inexpensive technique for the diagnosis of HSK. Immunological techniques applied on such smears provide virological results within 2-5 hours. This technique could be modified for use in the diagnosis of other external eye diseases, which needs further evaluation.

Tags: corneal-impression-cytology, epithelial-keratitis, herpes-simplex-keratitis, nih, viral-antigen-detection
Organization: U.S. Department of Health & Human Services
2023 Uniform Reporting System (URS) Table For Minnesota

This is the 2023 Uniform Reporting System (URS) Output Tables for Minnesota. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, evidence-based-practices, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Carbon and nitrogen substrate utilization by archival

Background
          A collection of over 20,000 Salmonella typhimurium LT2 mutants, sealed for four decades in agar stabs, is a unique resource for study of genetic and evolutionary changes. Previously, we reported extensive diversity among descendants including diversity in RpoS and catalase synthesis, diversity in genome size, protein content, and reversion from auxotrophy to prototrophy.
        
        
          Results
          Extensive and variable losses and a few gains of catabolic functions were observed by this standardized method. Thus, 95 catabolic reactions were scored in each of three plates in wells containing specific carbon and nitrogen substrates.
        
        
          Conclusion
          While the phenotype microarray did not reveal a distinct pattern of mutation among the archival isolates, the data did confirm that various isolates have used multiple strategies to survive in the archival environment. Data from the MacConkey plates verified the changes in carbohydrate metabolism observed in the Biolog™ system.

Tags: archival-isolates, carbon-nitrogen-utilization, metabolic-phenotyping, nih, salmonella-typhimurium
Organization: U.S. Department of Health & Human Services