AndreaBozzo/ceres-open-data-index huggingface dataset:
Debate: Transfusing to normal haemoglobin levels will not improve outcome

Recent evidence suggests that critically ill patients are able to tolerate lower levels of haemoglobin than was previously believed. It is our goal to show that transfusing to a level of 100 g/l does not improve mortality and other clinically important outcomes in a critical care setting. Although many questions remain, many laboratory and clinical studies, including a recent randomized controlled trial (RCT), have established that transfusing to normal haemoglobin concentrations does not improve organ failure and mortality in the critically ill patient. In addition, a restrictive transfusion strategy will reduce exposure to allogeneic transfusions, result in more efficient use of red blood cells (RBCs), save blood overall, and decrease health care costs.

Tags: anemia-treatment, blood-transfusion, critical-care, hemoglobin-levels, nih
Organization: U.S. Department of Health & Human Services
Compound 528479: Docosane, 2,6,10,15-tetramethyl

Chemical compound data from PubChem database. IUPAC Name: 2,6,10,15-tetramethyldocosane. Molecular Formula: C26H54. Molecular Weight: 366.7. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Chronic garlic administration protects rat heart against oxidative stress induced by ischemic reperfusion injury

Background
          Oxidative stress plays a major role in the biochemical and pathological changes associated with myocardial ischemic-reperfusion injury (IRI). The need to identify agents with a potential for preventing such damage has assumed great importance. Chronic oral administration of raw garlic has been previously reported to augment myocardial endogenous antioxidants. In the present study, the effect of chronic oral administration of raw garlic homogenate on oxidative stress induced by ischemic-reperfusion injury in isolated rat heart was investigated.
        
        
          Results
          Raw garlic homogenate (125, 250 and 500 mg/kg once daily for 30 days) was administered orally in Wistar albino rats. Thereafter, hearts were isolated and subjected to IRI (9 min. of global ischemia, followed by 12 min of reperfusion; perfusion with K-H buffer solution; 37°C, 60 mm Hg.). Significant myocyte injury and rise in myocardial TBARS along with reduction in myocardial SOD, catalase, GSH and GPx were observed following IRI. Depletion of myocardial endogenous antioxidants and rise in TBARS were significantly less in the garlic-treated rat hearts. Oxidative stress induced cellular damage as indicated by ultrastructural changes, like disruption of myofilament, Z-band architecture along with mitochondrial changes were significantly less.
        
        
          Conclusions
          The study strongly suggests that chronic garlic administration prevents oxidative stress and associated ultrastructural changes, induced by myocardial ischemic-reperfusion injury.

Tags: garlic-supplementation, ischemic-reperfusion-injury, nih, oxidative-stress, rat-heart
Organization: U.S. Department of Health & Human Services
Analysis of HIV-1 drug resistant mutations by line probe assay and direct sequencing in a cohort of therapy naive HIV-1 infected Italian patients

Background
          The routine determination of drug resistance in newly HIV-1 infected individuals documents a potential increase in the transmission of drug-resistant variants. Plasma samples from twenty seven therapy naive HIV-1 infected Italian patients were analyzed by the line probe assay (LIPA) and the TruGene HIV-1 assay for the detection of mutations conferring resistance to HIV-1.
        
        
          Results
          Both tests disclosed amino-acid substitutions associated with resistance in a variable number of patients. In particular, two mutations (K70R and V118I), detectable by LIPA and by sequencing analysis respectively, revealed resistance to NRTIs in two plasma samples. At least three mutations conferring resistance to NNRTIs, not detectable by commercial LIPA, able to reveal mutations associated only with nucleoside reverse transcriptase analogues, were disclosed by viral sequence analysis. Moreover, most samples showed mutations correlated with resistance to protease inhibitors. Remarkably, a key mutation, like V82A (found as a mixture), and some "indeterminate" results (9 samples), due the absence of signal on the lines corresponding to a specific probe, was revealed only by LIPA, while a variable number of secondary mutations was detectable only by TruGene HIV-1 assay.
        
        
          Conclusion
          Even if further studies are necessary to establish the impact of different tests on the evaluation of drug-resistant strains transmission, LIPA might be useful in a wide population analysis, where bulk results are needed in a short time, while sequencing analysis, able to detect mutations conferring resistance to both NRTIs and NNRTIs, might be considered a more complete assay, albeit more expensive and more technically complex.

Tags: drug-resistance-mutations, hiv-1-resistance, line-probe-assay, nih, therapy-naive-patients
Organization: U.S. Department of Health & Human Services
Quantitative analysis of DNA levels in maternal plasma in normal and Down syndrome pregnancies

Background
          We investigated fetal and total DNA levels in maternal plasma in patients bearing fetuses affected with Down syndrome in comparison to controls carrying fetuses with normal karyotype.
        
        
          Methods
          DNA levels in maternal plasma were measured using real-time quantitative PCR using SRY and β-globin genes as markers. Twenty-one pregnant women with a singleton fetus at a gestational age ranging from 15 to 19 weeks recruited before amniocentesis (carried out for reasons including material serum screening and advanced material age), and 16 pregnant women bearing fetuses affected with Down syndrome between 17 to 22 weeks of gestation were involved in the study.
        
        
          Results
          The specificity of the system reaches 100% (no Y signal was detected in 14 women pregnant with female fetuses) and the sensitivity 91.7% (SRY amplification in 22 of 24 examined samples). The median fetal DNA levels in women carrying Down syndrome (n=11) and the controls (n=13) were 23.3 (range 0–58.5) genome-equivalents/ml and 24.5 (range 0–47.5) genome-equivalents/ml of maternal plasma, respectively (P = 0.62). The total median DNA levels in pregnancies with Down syndrome and the controls were 10165 (range 615–65000) genome-equivalents/ml and 7330 (range 1300–36750) genome-equivalents/ml, respectively (P = 0.32). The fetal DNA proportion in maternal plasma was 0%-6 % (mean 0.8%) in women carrying Down syndrome and 0%-2.6 % (mean 0.7 %) in the controls, respectively (P=0.86).
        
        
          Conclusions
          Our study revealed no difference in fetal DNA levels and fetal DNA: maternal DNA ratio between the patients carrying Down syndrome fetuses and the controls.

Tags: down-syndrome, fetal-dna, maternal-plasma-dna, nih, prenatal-screening
Organization: U.S. Department of Health & Human Services
Compound 525294: 3-Chloro-2-ethylbut-2-enal

Chemical compound data from PubChem database. IUPAC Name: 3-chloro-2-ethylbut-2-enal. Molecular Formula: C6H9ClO. Molecular Weight: 132.59. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2012 State Profile - Indiana

This is a National Survey of Substance Abuse Treatment Services (N-SSATS) annual report showing the state profile for Indiana in 2012. N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 States, the District of Columbia, and other U.S. jurisdictions.

Tags: alcohol-drug-services, indiana, n-ssats, samhsa, substance-abuse-treatment
Organization: U.S. Department of Health & Human Services
2015 CMHS Uniform Reporting System Output Tables

2015 Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables. The URS is a state, national, and territories reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant, mental-health-services, outcome-measures, samhsa, state-mental-health
Organization: U.S. Department of Health & Human Services
Compound 525636: N,N-Dimethyl-N'-nonyl-p-methoxybenzamidine

Chemical compound data from PubChem database. IUPAC Name: 4-methoxy-N,N-dimethyl-N'-nonylbenzenecarboximidamide. Molecular Formula: C19H32N2O. Molecular Weight: 304.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Results from the 2010 National Survey on Drug Use and Health: Mental Health Findings

This page presents the report and detailed tables pertaining to mental health from the 2010 National Survey on Drug Use and Health (NSDUH). Both the report and detailed tables present national estimates of the prevalence of past year mental disorders and past year mental health service utilization for youths aged 12 to 17 and adults aged 18 or older. Among adults, estimates presented include rates and numbers of persons with any mental illness (AMI), serious mental illness (SMI), suicidal thoughts and behavior, major depressive episode (MDE), treatment for depression (among adults with MDE), and mental health service utilization. Estimates for youths include MDE, treatment for depression (among youths with MDE), and mental health service utilization. Measures related to the co-occurrence of mental disorders with substance use or with substance use disorders also are presented for both adults and youths. Results are provided for age group, gender, race/ethnicity, education level, employment status, poverty level, geographic area, insurance status. Comparisons are made between 2010 and 2002 to 2009.

Tags: major-depressive-episode, mental-health, mental-health-services, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
T Wave Alternans in high arrhythmic risk patients: Analysis in time and frequency domains: A pilot study

Background
          T wave alternans (TA) is a repolarisation phenomenon manifesting as a microvolt beat to beat change in the amplitude of the T wave and ST segment. TA has been shown to be a predictor of arrhythmic risk in unselected myocardial infarction populations. TA has not been used to differentiate risk within the ischaemic cardiomyopathy population.
        
        
          Methods
          The subjects investigated comprised, Group 1: 7 stable patients with remote (>20 months) extensive myocardial scarring and no arrhythmic events (NYHA 3 and 4). Group2: 9 post infarction patients with malignant arrhythmia and implantable defibrillator. During breath holding, 20 continuous QRST complexes from each patients X, Y and Z leads were digitally recorded. Time domain, resultant absolute difference vectors (ATA), were calculated for alternate resultant T wave sequences. Group differences between the magnitude and temporal distribution of mean ATAs and their spectral and cross-spectral analysis were compared.
        
        
          Results
          Group 1 v Group 2 mean ATAs were 10.7 (7.17) v 11.7 (8.48) respectively, not significant. Each group had a homogenous temporal distribution of ATAs. Both group's largest mean ATA frequency components were between 0 to 25 Hz, the largest ATA component being at the DC frequency. Cross spectral analysis showed no significant differences in group ATA frequency content.
        
        
          Conclusion
          The frequency content and microvolt magnitude of T wave alternans was not significantly different in these two groups. The specificity of T wave alternans for differentiating arrhythmic risk in post infarction scarring and heart failure needs investigation.

Tags: arrhythmic-risk, electrophysiology, myocardial-infarction, nih, t-wave-alternans
Organization: U.S. Department of Health & Human Services
Nevada (NV)

This report presents estimates for measures of substance use and mental health based on the combined 2010 and 2011 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for Nevada for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: mental-health, nevada-behavioral-health, nsduh-data, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
2010 State Profile — District of Columbia

This state profile includes data from facilities in the District of Columbia that reported to N-SSATS for the survey reference date March 31, 2010. Data were collected on the location, characteristics, services offered, and number of clients in treatment at alcohol and drug abuse treatment facilities (both public and private) in the District of Columbia. In the District of Columbia, 33 substance abuse treatment facilities were included in the 2010 N-SSATS, reporting that there were 4,548 clients in substance abuse treatment on March 31, 2010. The survey response rate in the District of Columbia was 81.0%.

Tags: alcohol-abuse-treatment, district-columbia, n-ssats, samhsa, substance-abuse-treatment
Organization: U.S. Department of Health & Human Services
2016 Uniform Reporting System (URS) Table for Utah

This is the 2016 Uniform Reporting System (URS) Output Tables for Utah. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-program, mental-health-services, national-outcome-measures, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
Nebraska (NE)

This report uses 2008 to 2010 National Survey on Drug Use and Health (NSDUH) to assess past year alcohol use disorder and illicit drug use disorder among persons aged 12 or older for Nebraska overall and for substate regions within Nebraska. Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE).

Tags: mental-health-indicators, nebraska, nsduh-data, samhsa, substance-use-disorder
Organization: U.S. Department of Health & Human Services
Compound 525476: 4-Ethyl-3,5-dithiaheptane

Chemical compound data from PubChem database. IUPAC Name: 1,1-bis(ethylsulfanyl)propane. Molecular Formula: C7H16S2. Molecular Weight: 164.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 525668: p-Bromobenzylidene-decyl-amine

Chemical compound data from PubChem database. IUPAC Name: 1-(4-bromophenyl)-N-decylmethanimine. Molecular Formula: C17H26BrN. Molecular Weight: 324.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
National Tables

Data tables consisting of Excel files with estimates, rates, relative standard errors, trends and confidence intervals, covering 2004-2011, for drug-related emergency department visits for the Nation. Tables are provided for 10 topics (\"analytic categories\") which are defined in the \"Guide to Drug Abuse Warning Trend Tables,\" a separate document.   Each table includes data for over 500 drugs, including illicit drugs, prescription and over-the-counter medications, dietary supplements, inhalants and alcohol. Includes total visits, gender, age group, race/ethnicity, outcome of visit, drug combinations, number of drugs involved in visit, drug frequency, and drugs confirmed by toxicology. Additional detail is provided for illicit drugs, psychotherapeutic drugs, central nervous system (CNS) drugs, respiratory drugs and cardiovascular drugs.

Tags: drug-overdose, drug-related-ed-visits, emergency-department-data, samhsa, substance-abuse-trends
Organization: U.S. Department of Health & Human Services
Mutation analysis of the CHK2 gene in breast carcinoma and other cancers

Background
          Mutations in the CHK2 gene at chromosome 22q12.1 have been reported in families with Li-Fraumeni syndrome. Chk2 is an effector kinase that is activated in response to DNA damage and is involved in cell-cycle pathways and p53 pathways.
        
        
          Methods
          We screened 139 breast tumors for loss of heterozygosity at chromosome 22q, using seven microsatellite markers, and screened 119 breast tumors with single-strand conformation polymorphism and DNA sequencing for mutations in the CHK2 gene.
        
        
          Results
          Seventy-four of 139 sporadic breast tumors (53%) show loss of heterozygosity with at least one marker. These samples and 45 tumors from individuals carrying the BRCA2 999del5 mutation were screened for mutations in the CHK2 gene. In addition to putative polymorphic regions in short mononucleotide repeats in a non-coding exon and intron 2, a germ line variant (T59K) in the first coding exon was detected. On screening 1172 cancer patients for the T59K sequence variant, it was detected in a total of four breast-cancer patients, two colon-cancer patients, one stomach-cancer patient and one ovary-cancer patient, but not in 452 healthy individuals. A tumor-specific 5' splice site mutation at site +3 in intron 8 (TTgt [a → c]atg) was also detected.
        
        
          Conclusion
          We conclude that somatic CHK2 mutations are rare in breast cancer, but our results suggest a tumor suppressor function for CHK2 in a small proportion of breast tumors. Furthermore, our results suggest that the T59K CHK2 sequence variant is a low-penetrance allele with respect to tumor growth.

Tags: breast-carcinoma, chk2-gene, loss-of-heterozygosity, mutation-analysis, nih
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Utah, 2015

This is a behavioral health report for the state of Utah. The report utilizes data from the National Survey on Drug Use and Health (NSDUH), and the Uniform Reporting System. The topics addressed in the report include youth substance use, youth mental health and treatment, mental health and treatment, substance use and substance use treatment.

Tags: mental-health-treatment, nsduh-data, samhsa, utah-behavioral-health, youth-substance-use
Organization: U.S. Department of Health & Human Services
2012 NSDUH Service Contract Act (SCA) Effects on Interviewers and Data Quality

This report provides an assessment of the possible impact of implementing the Service Contract Act (SCA) on interviewer staffing and data quality in the 2012 National Survey onDrug Use and Health (NSDUH).

Tags: data-quality, drug-use, nsduh, samhsa, survey-interviewers
Organization: U.S. Department of Health & Human Services
2018 Uniform Reporting System (URS) Table for Pennsylvania

This is the 2018 Uniform Reporting System (URS) Output Tables for Pennsylvania. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: behavioral-health, community-mental-health, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Marijuana Use and Perceived Risk of Harm from Marijuana Use Varies within and across States

This report uses 2012 to 2014 National Survey on Drug Use and Health (NSDUH) to assess past month marijuana use and perceptions of great risk of harm from smoking marijuana once a month among people aged 12 or older in 362 substate regions, the 50 states, and the District of Columbia.

Tags: marijuana-use, nsduh-data, risk-perception, samhsa, substate-regions
Organization: U.S. Department of Health & Human Services
Table 17. Alcohol Dependence or Abuse in the Past Year among Persons Aged 12 or Older, by State and Substate Regions: Percentages, Annual Averages Based on 2010, 2011, and 2012 NSDUHs

Table 17. Alcohol Dependence or Abuse in the Past Year among Persons Aged 12 or Older, by State and Substate Regions: Percentages, Annual Averages Based on 2010, 2011, and 2012 NSDUHs

Tags: alcohol-abuse, alcohol-dependence, nsduh-data, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Children’s Bureau Letter Regarding Existing Title IV-E Flexibility

This letter from the Children’s Bureau to state and tribal child welfare leaders describes existing flexibilities in the title IV-E program that may help agencies better serve children, youth, and families during the COVID-19 pandemic.

Browse All COVID-19 Resources

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: 19, child, covid, guidance, policy
Organization: U.S. Department of Health & Human Services
ANA Objective Progress Report

The ANA Objective Progress Rreport collects data on project status on all funded objectives and activities and tracks the progress of the project impact indicators.

<b>Units of Response: </b>ANA Grantees

<b>Type of Data: </b>Administrative

<b>Tribal Data: </b>Yes

<b>COVID-19 Data: </b>Unavailable

<b>Periodicity: </b>Unavailable

<b>SORN: </b>Not Applicable

<b>Data Use Agreement: </b>Unavailable

<b>Data Use Agreement Location: </b>Unavailable

<b>Equity Indicators: </b>Indigenous Population

<b>Granularity: </b>Grant

<b>Spatial: </b>United States

<b>Geocoding: </b>Unavailable

Tags: native-american-programs
Organization: U.S. Department of Health & Human Services
Compound 525223: Chloromethyl 7-chlorononanoate

Chemical compound data from PubChem database. IUPAC Name: chloromethyl 7-chlorononanoate. Molecular Formula: C10H18Cl2O2. Molecular Weight: 241.15. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services