AndreaBozzo/ceres-open-data-index huggingface dataset:
2015 CMHS Uniform Reporting System (URS) Table for Mississippi

2015 Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for Mississippi. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-program, mental-health-services, mississippi, outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Predicting residents' performance: A prospective study

Background
          Objective criteria for predicting residents' performance do not exist. The purpose of this study was to test the hypothesis that global assessment by an intern selection committee (ISC) would correlate with the future performance of residents.
        
        
          Methods
          A prospective study of 277 residents between 1992 and 1999. Global assessment at the time of interview was compared to subsequent clinical (assessed by chief residents) and cognitive performance (assessed by the American Board of Pediatrics in-service training examination).
        
        
          Results
          ISC ratings correlated significantly with clinical performance at 24 and 36 months of training (r = 0.58, P < .001; and r = 0.60, P < .001 respectively). ISC ratings also correlated significantly with in-service exam scores in the 1st, 2nd, and 3rd years of training (r = 0.35, P = .0016; r = 0.39, P = 0.0003; r = 0.50, P = 0.005 respectively).
        
        
          Conclusions
          Global assessment by an ISC predicted residents' clinical and cognitive performances.

Tags: clinical-assessment, medical-education, nih, predictive-modeling, resident-performance
Organization: U.S. Department of Health & Human Services
Risk and Protective Factors and Initiation of Substance Use: Results from the 2014 National Survey on Drug Use and Health

This report presents data from the 2002 through 2014 National Surveys on Drug Use and Health (NSDUHs) for trends in people’s perceptions of great risk of harm associated with the use of cigarettes, alcohol, and specific illicit drugs and the perceived availability of substances. The data are presented for the population aged 12 years old or older and for specific age groups. Trends in perceived great risk of harm associated with the use of specific substances (i.e., marijuana, alcohol, and cigarettes) were compared with trends in the use of these substances in the past 30 days. The report also includes trends for measures that are specific to youths aged 12 to 17, such as perceptions about parents strongly disapproving of youth substance use. Finally, this report includes trends in the estimated numbers of individuals who initiated substance use in the past year and the average age at first use among people who initiated use in the past year (i.e., past year initiates). The report focuses on long-term trends by comparing estimates from the 2014 NSDUH with NSDUH estimates in 2002 to 2013. Statistically significant differences are noted between estimates in 2014 and those in prior years.

Tags: nsduh-data, risk-perception, samhsa, substance-use-initiation, youth-substance-use
Organization: U.S. Department of Health & Human Services
Mitochondria from cultured cells derived from normal and thiamine-responsive megaloblastic anemia individuals efficiently import thiamine diphosphate

Background
          Thiamine diphosphate (ThDP) is the active form of thiamine, and it serves as a cofactor for several enzymes, both cytosolic and mitochondrial. Isolated mitochondria have been shown to take up thiamine yet thiamine diphosphokinase is cytosolic and not present in mitochondria. Previous reports indicate that ThDP can also be taken up by rat mitochondria, but the kinetic constants associated with such uptake seemed not to be physiologically relevant.
        
        
          Results
          Here we examine ThDP uptake by mitochondria from several human cell types, including cells from patients with thiamine-responsive megaloblastic anemia (TRMA) that lack a functional thiamine transporter of the plasma membrane. Although mitochondria from normal lymphoblasts took up thiamine in the low micromolar range, surprisingly mitochondria from TRMA lymphoblasts lacked this uptake component. ThDP was taken up efficiently by mitochondria isolated from either normal or TRMA lymphoblasts. Uptake was saturable and biphasic with a high affinity component characterized by a Km of 0.4 to 0.6 μM. Mitochondria from other cell types possessed a similar high affinity uptake component with variation seen in uptake capacity as revealed by differences in Vmax values.
        
        
          Conclusions
          The results suggest a shared thiamine transporter for mitochondria and the plasma membrane. Additionally, a high affinity component of ThDP uptake by mitochondria was identified with the apparent affinity constant less than the estimates of the cytosolic concentration of free ThDP. This finding indicates that the high affinity uptake is physiologically significant and may represent the main mechanism for supplying phosphorylated thiamine for mitochondrial enzymes.

Tags: megaloblastic-anemia, mitochondrial-transport, nih, thiamine-diphosphate, trma-syndrome
Organization: U.S. Department of Health & Human Services
Michigan (MI)

This report uses 2008 to 2010 National Survey on Drug Use and Health (NSDUH) to assess past year alcohol use disorder and illicit drug use disorder among persons aged 12 or older for Michigan overall and for substate regions within Michigan. Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE).

Tags: ami-smi-mde, mental-health-indicators, michigan-health-survey, samhsa, substance-use-disorder
Organization: U.S. Department of Health & Human Services
Imaging of Dynamic Changes of the Actin Cytoskeleton in Microextensions of Live NIH3T3 Cells with a GFP Fusion of the F-Actin Binding Domain of Moesin

Background
          The cell surface undergoes continuous change during cell movement. This is characterized by transient protrusion and partial or complete retraction of microspikes, filopodia, and lamellipodia. This requires a dynamic actin cytoskeleton, moesin, components of Rho-mediated signal pathways, rearrangement of membrane constituents and the formation of focal adhesion sites. While the immunofluorescence distribution of endogenous moesin is that of a membrane-bound molecule with marked enhancement in some but not all microextensions, the C-terminal fragment of moesin co-distributes with filamentous actin consistent with its actin-binding activity. By taking advantage of this property we studied the spontaneous protrusive activity of live NIH3T3 cells, expressing a fusion of GFP and the C-terminal domain of moesin.
        
        
          Results
          C-moesin-GFP localized to stress fibers and was enriched in actively protruding cellular regions such as filopodia or lamellipodia. This localization was reversibly affected by cytochalasin D. Multiple types of cytoskeletal rearrangements were observed that occurred independent of each other in adjacent regions of the cell surface. Assembly and disassembly of actin filaments occurred repeatedly within the same space and was correlated with either membrane protrusion and retraction, or no change in shape when microextensions were adherent.
        
        
          Conclusions
          Shape alone provided an inadequate criterion for distinguishing between retraction fibers and advancing, retracting or stable filopodia. Fluorescence imaging of C-moesin-GFP, however, paralleled the rapid and dynamic changes of the actin cytoskeleton in microextensions. Regional regulatory control is implicated because opposite changes occurred in close proximity and presumably independent of each other. This new and sensitive tool should be useful for investigating mechanisms of localized actin dynamics in the cell cortex.

Tags: actin-cytoskeleton, cell-motility, moesin-protein, nih, nih3t3-cells
Organization: U.S. Department of Health & Human Services
Compound 525652: N,N-Dimethyl-N'-propyl-p-methylbenzamidine

Chemical compound data from PubChem database. IUPAC Name: N,N,4-trimethyl-N'-propylbenzenecarboximidamide. Molecular Formula: C13H20N2. Molecular Weight: 204.31. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: HHS Regions, Volume 7

Explore state and regional data with these user-friendly behavioral health reports for each of the ten HHS regions of the United States. Each report uses data from the 2021-2022 National Surveys on Drug Use and Health (NSDUH). The topics addressed in the reports include substance use, substance use disorders, and mental health. Selected estimates are provided for adolescents aged 12 to 17, underage people aged 12 to 20, adults aged 18 or older, and the general population aged 12 or older. Statistical tests compare population percentages of (1) HHS region versus national estimates, (2) state versus national estimates, and (3) state versus HHS region estimates.

Tags: behavioral-health, mental-health, nsduh-data, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Ohio (OH)

This report presents estimates for measures of substance use and mental health based on the combined 2010 and 2011 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for Ohio for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: mental-health, nsduh-data, ohio-survey, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
2017 Uniform Reporting System (URS) Table for Alabama

This is the 2017 Uniform Reporting System (URS) Output Tables for Alabama. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: alabama-mental-health, mental-health-services, national-outcome-measures, samhsa, substance-abuse-treatment
Organization: U.S. Department of Health & Human Services
Health Insurance Status of Adult Substance Abuse Treatment Admissions Aged 26 or Older: 2011

A Treatment Episode Data Set (TEDS) report that provides baseline characteristics for health insurance coverage among adults. This analysis restricts admissions to those aged 26 or older at treatment entry given the ACA's provision that extends health care coverage in family policies to adult children until age 26 using 2011 data.

Tags: adult-treatment-admissions, health-insurance-coverage, samhsa, substance-abuse-treatment, teds-data
Organization: U.S. Department of Health & Human Services
Genetics University of Toronto Thrombophilia Study in Women (GUTTSI): genetic and other risk factors for venous thromboembolism in women

Background
          Women may be at increased risk for venous thromboembolism (VTE) as compared with men. We studied the effects of genetic and biochemical markers of thrombophilia in women, in conjunction with other established risk factors for VTE.
        
        
          Method
          The present retrospective case-control study was conducted in a thrombosis treatment programme at a large Toronto hospital. The cases were 129 women aged 16-79 years with objectively confirmed VTE. Age-matched control individuals were women who were free of venous thrombosis. Neither cases nor control individuals had known cardiovascular disease. Participants were interviewed regarding personal risk factors for VTE, including smoking, history of malignancy, pregnancy, and oestrogen or oral contraceptive use. Blood specimens were analyzed for common single nucleotide polymorphisms of prothrombin, factor V and methylenetetrahydrofolate reductase (MTHFR; C677T, A1298C and T1317C), and the A66G polymorphism for methionine synthase reductase (MTRR).Fasting plasma homocysteine was also analyzed.
        
        
          Results
          Women with VTE were significantly more likely than female control individuals to carry the prothrombin polymorphism and the factor V polymorphism, or to have fasting hyperhomocysteinaemia. Homozygosity for the C677T MTHFR gene was not a significant risk factor for VTE, or were the A1298C or T1317C MTHFR homozygous variants. Also, the A66G MTRR homozygous state did not confer an increased risk for VTE.
        
        
          Conclusion
          Prothrombin and factor V polymorphisms increased the risk for VTE in women, independent from other established risk factors. Although hyperhomocysteinaemia also heightens this risk, common polymorphisms in two genes that are responsible for homocysteine remethylation do not. These findings are consistent with previous studies that included both men and women.

Tags: case-control-study, nih, thrombophilia-genetics, venous-thromboembolism, womens-health
Organization: U.S. Department of Health & Human Services
2020 Uniform Reporting System (URS) Table For Oklahoma

This is the 2020 Uniform Reporting System (URS) Output Tables for Oklahoma. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-data, mental-health-services, oklahoma, outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Table 25. 2011-2012 NSDUH Had Serious Thoughts of Suicide in the Past Year, by Age Group and State

Table 25. Had Serious Thoughts of Suicide in the Past Year, by Age Group and State: Percentages, Annual Averages Based on 2011 and 2012 NSDUHs. Results are provided by State and for four age groups: 18 to 25, 26 or older, 18 or older and all persons 18 or older.

Tags: age-groups, mental-health, nsduh-survey, samhsa, suicidal-ideation
Organization: U.S. Department of Health & Human Services
2018 Uniform Reporting System (URS) Table for Colorado

This is the 2018 Uniform Reporting System (URS) Output Tables for Colorado. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.Report Level

Tags: colorado-health, mental-health-services, national-outcome-measures, samhsa, substance-abuse-treatment
Organization: U.S. Department of Health & Human Services
Compound 525231: Chloromethyl octanoate

Chemical compound data from PubChem database. IUPAC Name: chloromethyl octanoate. Molecular Formula: C9H17ClO2. Molecular Weight: 192.68. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 528422: Dihydrochalcone, 2',6',4-trihydroxy-4'-methoxy, tris-TMS

Chemical compound data from PubChem database. IUPAC Name: 3-[4-methoxy-2,6-bis(trimethylsilyloxy)phenyl]-1-(4-trimethylsilyloxyphenyl)propan-1-one. Molecular Formula: C25H40O5Si3. Molecular Weight: 504.8. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2023 Uniform Reporting System (URS) Table For Federated States of Micronesia

This is the 2023 Uniform Reporting System (URS) Output Tables for Federated States of Micronesia. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: mental-health-services, micronesia, national-outcome-measures, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
Strengthening Families Through Primary Prevention of Child Maltreatment and Unnecessary Parent-Child Separation

This Information Memorandum (IM) strongly encourages all child welfare agencies and Children’s Bureau (CB) grantees to work together with the courts and other appropriate public and private agencies and partners to plan, implement and maintain integrated primary prevention networks and approaches to strengthen families and prevent maltreatment and the unnecessary removal of children from their families.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: child, grant, maltreatment, policy, prevention
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: New Jersey, 2013

This is a behavioral health report for the state of New Jersey. It uses the  National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment Services (NSSATS) to address the topics of youth substance use , youth mental health and treatment, adult mental health and treatment, substance use, substance use treatment  for the years 2008 to 2012.

Tags: behavioral-health, mental-health, new-jersey, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
4-(N,N-dipropylamino)benzaldehyde inhibits the oxidation of

Background
          The signal transduction pathways mediated by retinoic acid play a critical role in the regulation of cell growth and differentiation during embryogenesis and hematopoiesis as well as in a variety of tumor cell lines in culture. Following the reports that two members of the superfamily of aldehyde dehydrogenase (ALDH) enzymes, ALDH1A1 and ALDH1A2, were capable of catalyzing the oxidation of all-trans retinal to all-trans retinoic acid with submicromolar Km values, we initiated an investigation of the ability of 4-(N,N-dipropylamino)benzaldehyde (DPAB) to inhibit the oxidation of retinal by purified mouse and human ALDH1A1.
        
        
          Results
          Our results show that DPAB potently inhibits retinal oxidation, with IC50 values of 0.11 and 0.13 μM for purified mouse and human ALDH1A1, respectively. Since the HL-60 human myeloid leukemic cell line has been used extensively to study the retinoic acid induced differentiation of HL-60 cells to granulocytes, and ALDH1A1 activity had previously been reported in HL-60 cells, we investigated the ability of DPAB to block differentiation of HL-60 promyelocytic leukemia cells exposed to retinal in culture. In HL-60 cells coincubated with 1 μM retinal and 50 μM DPAB for 144 hours, cell differentiation was inhibited only 30%. Furthermore, the NAD-dependent oxidation of propanal or retinal was less than 0.05 nmoles NADH formed/min-107 cells in spectrophotometric assays using HL-60 cell extracts.
        
        
          Conclusion
          Although ALDH1A1 may be the major catalytic activity for retinal oxidation in some retinoid-dependent mouse and Xenopus embryonic tissues and in adult human and mouse hematopoietic stem cells, another catalytic activity appears to synthesize the retinoic acid ligand necessary to stimulate the differentiation of HL-60 cells to end stage granulocytes.

Tags: aldehyde-dehydrogenase, enzyme-inhibition, leukemia-cells, nih, retinoic-acid
Organization: U.S. Department of Health & Human Services
Vermont (VT)

This report presents estimates for measures of substance use and mental health based on the combined 2010 and 2011 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for Vermont for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: ami-smi-mde, mental-health, samhsa, substance-use, vermont-survey
Organization: U.S. Department of Health & Human Services
2016 Uniform Reporting System (URS) Table for Arizona

This is the 2016 Uniform Reporting System (URS) Output Tables for Arizona. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: arizona, mental-health-services, national-outcome-measures, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
The International Sepsis Forum's controversies in sepsis: how will sepsis be treated in 2051?

Great advances have been made in describing the intracellular pathways and genes that are activated by bacterial products. New definitions and therapies for sepsis will be based on such cellular and genetic alterations. In particular, in 2051 sepsis will no longer be defined simply as a clinical constellation of findings, but rather will be divided into different entities dependent on the intracellular cascades or genes activated. Similarly, therapies will be specifically directed at such functional genetic or biochemical alterations, thereby permitting more rational therapy of specific cellular abnormalities in infected patients. Supportive care will also have advanced by 2051, allowing for less iatrogenic harm to critically ill septic patients. Finally, a better appreciation of the cellular and genetic pathways that are activated in patients will permit an improved understanding of prognosis in critically ill infected patients, allowing more appropriate use of therapies.

Tags: nih, sepsis-definition, sepsis-genetics, sepsis-prognosis, sepsis-treatment
Organization: U.S. Department of Health & Human Services
2013 NSDUH Tobacco Product and Alcohol Use Tables (Standard Errors and P Values) - 2.1 to 2.84

These detailed tables present standard errors for totals and prevalence estimates of tobacco and alcohol use from the 2013 National Survey on Drug Use and Health (NSDUH). Tobacco products include cigarettes, smokeless tobacco, cigars, and pipe tobacco. Alcohol use includes binge and heavy alcohol use. Standard errors are provided for lifetime, past year, and past month use by age group, gender, race/ethnicity, education level, employment status, and geographic area. Standard errors are provided for both 2013 and 2012.

Tags: alcohol-consumption, nsduh-data, samhsa, substance-use-survey, tobacco-use
Organization: U.S. Department of Health & Human Services