AndreaBozzo/ceres-open-data-index huggingface dataset:
Oklahoma 2016 Potential Areas for Addressing Service Gaps for Opioid Treatment

The purpose of the medication-assisted treatment (MAT) facility maps is to identify areas on a state-by-state basis that may be potentially underserved by existing treatment facilities. The maps are created with a methodology that seeks to include the highest potential need areas from individual counties so that county-level stakeholders are also informed. The maps are meant to be used as a tool for policy makers to determine potentially underserved areas—not as a definitive representation of these areas.

Tags: mat-access, oklahoma-opioids, opioid-treatment, samhsa, service-gap-analysis
Organization: U.S. Department of Health & Human Services
2014 CMHS Uniform Reporting System (URS) Table for Illinois

2014 Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for Illinois. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: illinois, mental-health-services, outcome-measures, samhsa, urs-data
Organization: U.S. Department of Health & Human Services
2020 NSDUH Detailed Tables

Get detailed national estimates from the 2020 National Survey on Drug Use and Health (NSDUH). The tables provide comprehensive statistics on substance use, mental health, and treatment in the United States. Although past year estimates are provided, they cannot be compared to 2020 estimates. This is because changes in survey methodology mean the indicators are not comparable to past NSDUH estimates.The tables are based on the NSDUH survey, which interviews people ages 12 or older in the civilian, noninstitutionalized population. In the tables, indicators are broken out by a variety of demographic, geographic, and economic variables.The following topics are covered, among others: drug, alcohol, nicotine, and tobacco product use and initiation; substance use disorder (SUD); substance use risk and protective factors; availability of substance use treatment; any mental illness (AMI) and serious mental illness (SMI); major depressive episode (MDE); suicidal thoughts and behaviors; serious psychological distress (SPD); mental health service utilization; treatment for depression; and co-occurrence of mental health issues and SUDs. In 2020, these tables also present the perceived effects of the Coronavirus Disease 2019 (COVID-19) pandemic on substance use and mental health.1All of the tables can be downloaded in a zip file which contains both an html and PDF file containing every table. Alternatively, users can open the clickable Table of Contents to go to a particular section. Click on “PE” to get to a population estimate or percentage table, and “SE” to get a standard error table.1. Please note that selected tables have been revised.

Tags: ami-smi, mental-health, samhsa, substance-use, suicidal-ideation
Organization: U.S. Department of Health & Human Services
Early response genes induced in chondrocytes stimulated with the inflammatory cytokine interleukin-1beta

Recent work has established that IL-1β plays a central role in the inflammation and connective tissue destruction observed in both rheumatoid arthritis and osteoarthritis. These processes result from the ability of this inflammatory cytokine to activate expression of genes for neutral proteases, such as the matrix metalloproteinases. While IL-1β activates matrix metalloproteinase genes within several hours, it also activates immediate early genes, which are required for the later expression of matrix metalloproteinases and other arthritis-perpetuating genes, are also activated. To identify putative immediate early genes involved in IL-1β-mediated arthritic disease, a chondrocytic cell line (SW1353) was stimulated with this cytokine for 2 hours, total RNA was isolated, and expressed genes were identified by microarray analysis. This analysis identified alterations in the expression of multiple transcription factors, cytokines, growth factors and their receptors, adhesion molecules, proteases, and signaling intermediates that may contribute to inflammation and cartilage destruction in arthritis. Interestingly, confirmation of the expression of activating protein-1 family members by reverse transcriptase polymerase chain reaction revealed a preferential increase in junB, a known transcriptional antagonist of c-jun. The failure to observe induction of early growth response gene-1, which was detected by reverse transcriptase polymerase chain reaction to be substantially and transiently induced by 1 hour of IL-1 treatment, may be explained by the known instability of the message after early induction. However, this analysis has identified numerous IL-1β-responsive genes that warrant further investigation as mediators of disease in arthritis.

Tags: chondrocyte-gene-expression, il-1beta-stimulation, inflammatory-cytokine, nih, osteoarthritis-research
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Indiana, 2014

This is a behavioral health report for the state of Indiana. It uses the National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment Services (NSSATS) to address the topics of youth substance use, youth mental health and treatment, adult mental health and treatment, substance use, and substance use treatment for the years 2009 to 2013.

Tags: behavioral-health, indiana, mental-health, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Survey of human mitochondrial diseases using new genomic/proteomic tools

Background
          We have constructed Bayesian prior-based, amino-acid sequence profiles for the complete yeast mitochondrial proteome and used them to develop methods for identifying and characterizing the context of protein mutations that give rise to human mitochondrial diseases. (Bayesian priors are conditional probabilities that allow the estimation of the likelihood of an event - such as an amino-acid substitution - on the basis of prior occurrences of similar events.) Because these profiles can assemble sets of taxonomically very diverse homologs, they enable identification of the structurally and/or functionally most critical sites in the proteins on the basis of the degree of sequence conservation. These profiles can also find distant homologs with determined three-dimensional structures that aid in the interpretation of effects of missense mutations.
        
        
          Results
          This survey reports such an analysis for 15 missense mutations, one insertion and three deletions involved in Leber's hereditary optic neuropathy, Leigh syndrome, mitochondrial neurogastrointestinal encephalomyopathy, Mohr-Tranebjaerg syndrome, iron-storage disorders related to Friedreich's ataxia, and hereditary spastic paraplegia. We present structural correlations for seven of the mutations.
        
        
          Conclusions
          Of the 19 mutations analyzed, 14 involved changes in very highly conserved parts of the affected proteins. Five out of seven structural correlations provided reasonable explanations for the malfunctions. As additional genetic and structural data become available, this methodology can be extended. It has the potential for assisting in identifying new disease-related genes. Furthermore, profiles with structural homologs can generate mechanistic hypotheses concerning the underlying biochemical processes - and why they break down as a result of the mutations.

Tags: genomic-analysis, missense-mutation, mitochondrial-diseases, nih, proteomic-analysis
Organization: U.S. Department of Health & Human Services
Michigan 2016 Potential Areas for Addressing Service Gaps for Opioid Treatment

The purpose of the medication-assisted treatment (MAT) facility maps is to identify areas on a state-by-state basis that may be potentially underserved by existing treatment facilities. The maps are created with a methodology that seeks to include the highest potential need areas from individual counties so that county-level stakeholders are also informed. The maps are meant to be used as a tool for policy makers to determine potentially underserved areas—not as a definitive representation of these areas.

Tags: mat-access, michigan, opioid-treatment, samhsa, service-gaps
Organization: U.S. Department of Health & Human Services
Utility of postintubation chest radiographs in the intensive care
		  unit

Objective:
          To determine the clinical usefulness of immediate (stat) chest
				radiographs after endotracheal intubation when performed by experienced
				critical care personnel.
        
        
          Patients and methods:
          This was a prospective study. Endotracheal intubations in an
				11-bed intensive care unit and a nine-bed intermediate intensive care unit were
				included. After intubations were performed by an experienced critical care
				operator, that individual recorded demographic and procedural data, and
				predicted radiographic findings on a data collection sheet. Experience at
				intubation was stratified into four levels of lifetime experience: fewer than
				10 procedures, 10-20 procedures, 20-50 procedures, and more than 50 procedures.
				Radiographic findings evaluated included endotracheal tube position and
				procedure-related complications. The postintubation chest radiograph was then
				reviewed and the actual findings were also recorded.
        
        
          Results:
          A total of 101 evaluable intubations were recorded, two of which
				were predicted to show tube malposition. Actual radiographic findings revealed
				10 malpositions, three of which were too high and seven were too low (one at
				the level of the carina). A single witnessed aspiration that occurred during
				intubation was not radiographically apparent until 24 h later. Only the tube
				positioned at the carina was felt to be of acute clinical significance or to
				place the patient at any acute risk.
        
        
          Conclusions:
          The incidence of endotracheal tube malposition after intubation
				was underestimated. However, when performed by experienced critical care
				personnel, acutely significant malpositions were rare (one out of 101
				intubations). We conclude that, in the absence of specific pulmonary
				complications, endotracheal intubations performed by experienced operators may
				be followed by routine, rather than 'stat' chest radiographs.

Tags: endotracheal-intubation, icu-patients, nih, postintubation-radiography, tube-placement
Organization: U.S. Department of Health & Human Services
2017 Uniform Reporting System (URS) Table for Nebraska

This is the 2017 Uniform Reporting System (URS) Output Tables for Nebraska. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-program, mental-health-services, national-outcome-measures, nebraska, samhsa
Organization: U.S. Department of Health & Human Services
Child is Identified as a Special Needs Adoption: 10/1/2010 - 9/30/2011

This report provides state-specific data from fiscal year 2011 about whether an adoption through a public agency was identified as a special needs adoption.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: adoption, data, fiscal, need, policy
Organization: U.S. Department of Health & Human Services
2022 Uniform Reporting System (URS) Table For Kentucky

This is the 2022 Uniform Reporting System (URS) Output Tables for Kentucky. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, kentucky, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Early bronchopulmonary involvement in Crohn disease: a case report

Background
          Bronchopulmonary manifestations of Crohn disease have been rarely described in children, including both subclinical pulmonary involvement and severe lung disease.
        
        
          Case presentation
          A 6.5-year-old girl is described with early recurrent bronchopulmonary symptoms both at presentation and in the quiescent phase of Crohn disease. Pulmonary function tests (lung volumes and flows, bronchial reactivity and carbon monoxide diffusing capacity) were normal. Bronchoalveolar cytology showed increased (30%) lymphocyte counts and bronchial biopsy revealed thickening of basal membrane and active chronic inflammation.
        
        
          Conclusions
          Clinical and histological findings in our young patient suggest involvement of both distal and central airways in an early phase of lung disease. The pathogenesis of Crohn disease-associated lung disorders is discussed with reference to the available literature. A low threshold for pulmonary evaluation seems to be advisable in all children with CD.

Tags: bronchopulmonary-disease, crohn-disease, lung-inflammation, nih, pediatric-health
Organization: U.S. Department of Health & Human Services
Tetramethylpyrazine attenuates spinal cord ischemic injury due to aortic cross-clamping in rabbits

Background
          Lower limb paralysis occurs in 11% of patients after surgical procedure of thoracic or thoracoabdominal aneurysms and is an unpredictable and distressful complication. The aim of this study was to investigate the effects of tetramethylpyrazine (TMP), an intravenous drug made from traditional Chinese herbs, on the neurologic outcome and hisotpathology after transient spinal cord ischemia in rabbits.
        
        
          Methods
          Forty-five male New Zealand white rabbits were anesthetized with isoflurane and spinal cord ischemia was induced for 20 min by infrarenal aortic occlusion. Animals were randomly allocated to one of five groups (n = 8 each). Group C received no pharmacologic intervention. Group P received intravenous infusion of 30 mg·kg-1 TMP within 30 min before aortic occlusion. Group T1, Group T2 and Group T3 received intravenous infusion of 15, 30 and 60 mg·kg-1 TMP respectively within 30 min after reperfusion. In the sham group (n = 5), the animals underwent the same procedures as the control group except infrarental aortic unocclusion. Neurologic status was scored by using the Tarlov criteria (in which 4 is normal and 0 is paraplegia) at 4 h, 8 h, 12 h, 24 h, and 48 h after reperfusion. All animals were sacrificed at 48 h after reperfusion and the spinal cords (L5) were removed immediately for histopathologic study.
        
        
          Results
          All animals in the control group became paraplegic. Neurologic status and histopathology (48 h) in the Groups P, T2 and T3 were significantly better than those in the control group (P < 0.05). There was a strong correlation between the final neurologic scores and the number of normal neurons in the anterior spinal cord (r = 0.776, P < 0.01).
        
        
          Conclusion
          Tetramethylpyrazine significantly reduces neurologic injury related to spinal cord ischemia and reperfusion after aortic occlusion within a certain range of dose.

Tags: aortic-cross-clamping, nih, rabbit-model, spinal-cord-ischemia, tetramethylpyrazine
Organization: U.S. Department of Health & Human Services
Compound 525142: Decaethylene glycol, diacetate

Chemical compound data from PubChem database. IUPAC Name: 2-[2-[2-[2-[2-[2-[2-[2-[2-(2-acetyloxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl acetate. Molecular Formula: C24H46O13. Molecular Weight: 542.6. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2017 Uniform Reporting System (URS) Table for Vermont

This is the 2017 Uniform Reporting System (URS) Output Tables for Vermont. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-data, mental-health-services, noms-measures, samhsa, vermont-urs
Organization: U.S. Department of Health & Human Services
Compound 525270: N'-(3-fluoro-phenyl)-N,N-dimethyl-formamidine

Chemical compound data from PubChem database. IUPAC Name: N'-(3-fluorophenyl)-N,N-dimethylmethanimidamide. Molecular Formula: C9H11FN2. Molecular Weight: 166.2. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Child and Family Services Reviews Update Volume 17, Issue 4, September 2023

This issue of Child and Family Services Reviews Update contains the following sections: CFSR Round 4 is Underway as Year 2 Approaches, Capacity Building Center for States - CFSR Round 4 Community of Practice Opportunity, Legal and Judicial Communities' Involvement Encouraged in All CFSR Phases, CB's Vision for Final Results Meetings and PIP Development, and Spanish Translations Added to Portal.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: assessment, child, policy, scope, state
Organization: U.S. Department of Health & Human Services
Proinflammatory activity of TWEAK on human dermal fibroblasts and synoviocytes: blocking and enhancing effects of anti-TWEAK monoclonal antibodies

Human tumour necrosis factor (TNF)-like weak inducer of apoptosis (hTWEAK) and two anti-hTWEAK mAbs were tested for their ability to elicit or block inflammatory responses in cultured human dermal fibroblasts and synoviocytes. Incubation with hTWEAK increased the production of prostaglandin E2, matrix metalloproteinase-1 (MMP-1), IL-6, and the chemokines IL-8, RANTES (regulated on activation, normal T expressed and secreted) and interferon-γ-inducible protein-10 (IP-10) in culture supernatant of fibroblasts and synoviocytes. In combination with TNF or IL-1β, hTWEAK further stimulated the secretion of prostaglandin E2, MMP-1, IL-6 and IL-8 up to fourfold, and IP-10 and RANTES up to 70-fold compared to TNF or IL-1β alone. An anti-hTWEAK mAb, BCB10, blocked the effects of hTWEAK, whereas hTWEAK crosslinked by the anti-hTWEAK mAb, BEB3, further stimulated the inflammatory response of fibroblasts and synoviocytes. The anti-hTWEAK mAbs were ineffective in blocking or increasing the responses of TNF or IL-1β and blocking anti-TNF mAb was ineffective in preventing the responses to TWEAK. These results were also confirmed at the RNA level for MMP-1, macrophage chemoattractant protein-1, RANTES, macrophage inflammatory protein-1α, IP-10 and IL-8. TWEAK in synergism with IL-1 and TNF may be an additional cytokine that plays a role in destructive chronic arthritic diseases.

Tags: fibroblast-inflammation, nih, prostaglandin-e2, synoviocyte-inflammation, tweak-cytokine
Organization: U.S. Department of Health & Human Services
Immunity status against poliomyelitis in Germany: Determination of cut-off values in International Units

Background
          To prevent importations of wild polioviruses into a polio free region a high level of population immunity must be kept. Standard methodology for determination of polio antibodies is a feature aimed at obtaining consistent results. An International Standard Serum for polio antibodies exists, but no protective level in International Units is defined.
        
        
          Methods
          A representative study was carried out in order to determine the serological status against poliomyelitis in Germany (n = 2564, age 18–79 years). Furthermore, sera from persons aged less than 18 years were included (n = 881). Microneutralization test has been used for determination of antibody levels. Results have been expressed in International Units.
        
        
          Results
          The results of this study indicate that the cut-off level for polio antibodies is 0.075 IU/ml for Polio 1, 0.180 IU/ml for Polio 2 and 0.080 IU/ml for Polio 3. Neutralizing antibodies against poliovirus type 1, 2 and 3 were detected in 96.2%, 96.8% and 89.6% of samples, respectively.
        
        
          Conclusions
          Overall, this seroprevalence indicates a very high level of immunity of the general population. It must be kept after the switch of immunization strategy from attenuated to inactivated vaccine in Germany.

Tags: microneutralization-test, nih, polio-antibodies, poliomyelitis-immunity, seroprevalence-germany
Organization: U.S. Department of Health & Human Services
Identification of protein tyrosine phosphatase 1B and casein as substrates for 124-v-Mos

Background
          The mos proto-oncogene encodes a cytoplasmic serine/threonine-specific protein kinase with crucial function during meiotic cell division in vertebrates. Based on oncogenic amino acid substitutions the viral derivative, 124-v-Mos, displays constitutive protein kinase activity and functions independent of unknown upstream effectors of mos protein kinase. We have utilized this property of 124-v-Mos and screened for novel mos substrates in immunocomplex kinase assays in vitro.
        
        
          Results
          We generated recombinant 124-v-Mos using the baculovirus expression system in Spodoptera frugiperda cells and demonstrated constitutive kinase activity by the ability of 124-v-Mos to auto-phosphorylate and to phosphorylate vimentin, a known substrate of c-Mos. Using this approach we analyzed a panel of acidic and basic substrates in immunocomplex protein kinase assays and identified novel in vitro substrates for 124-v-Mos, the protein tyrosine phosphatase 1B (PTP1B), alpha-casein and beta-casein. We controlled mos-specific phosphorylation of PTP1B and casein in comparative assays using a synthetic kinase-inactive 124-v-Mos mutant and further, tryptic digests of mos-phosphorylated beta-casein identified a phosphopeptide specifically targeted by wild-type 124-v-Mos. Two-dimensional phosphoamino acid analyses showed that 124-v-mos targets serine and threonine residues for phosphorylation in casein at a 1:1 ratio but auto-phosphorylation occurs predominantly on serine residues.
        
        
          Conclusion
          The mos substrates identified in this study represent a basis to approach the identification of the mos-consensus phosphorylation motif, important for the development of specific inhibitors of the Mos protein kinase.

Tags: enzyme-substrates, kinase-assays, mos-proto-oncogene, nih, protein-phosphorylation
Organization: U.S. Department of Health & Human Services
2020 Uniform Reporting System (URS) Table For Pennsylvania

This is the 2020 Uniform Reporting System (URS) Output Tables for Pennsylvania. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, evidence-based-practices, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services