AndreaBozzo/ceres-open-data-index huggingface dataset:
Notice of court ordered nationwide stay of the Designated Placements Final Rule

The purpose of this Information Memorandum is to inform state and tribal title IV-B and title IV-E agencies of a nationwide stay of the Designated Placements Final Rule and corresponding regulation at 45 CFR 1355.22
  
  

.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: child, compliance, guidance, policy, regulation
Organization: U.S. Department of Health & Human Services
Noncoding RNA gene detection using comparative sequence analysis

Background
          Noncoding RNA genes produce transcripts that exert their function without ever producing proteins. Noncoding RNA gene sequences do not have strong statistical signals, unlike protein coding genes. A reliable general purpose computational genefinder for noncoding RNA genes has been elusive.
        
        
          Results
          We describe a comparative sequence analysis algorithm for detecting novel structural RNA genes. The key idea is to test the pattern of substitutions observed in a pairwise alignment of two homologous sequences. A conserved coding region tends to show a pattern of synonymous substitutions, whereas a conserved structural RNA tends to show a pattern of compensatory mutations consistent with some base-paired secondary structure. We formalize this intuition using three probabilistic "pair-grammars": a pair stochastic context free grammar modeling alignments constrained by structural RNA evolution, a pair hidden Markov model modeling alignments constrained by coding sequence evolution, and a pair hidden Markov model modeling a null hypothesis of position-independent evolution. Given an input pairwise sequence alignment (e.g. from a BLASTN comparison of two related genomes) we classify the alignment into the coding, RNA, or null class according to the posterior probability of each class.
        
        
          Conclusions
          We have implemented this approach as a program, QRNA, which we consider to be a prototype structural noncoding RNA genefinder. Tests suggest that this approach detects noncoding RNA genes with a fair degree of reliability.

Tags: gene-detection, nih, noncoding-rna, sequence-analysis, structural-rna
Organization: U.S. Department of Health & Human Services
Peroxisome proliferator-activated receptor agonists prevent 25-OH-cholesterol induced c-jun activation and cell death

Background
          Cholesterol oxides, the oxygenated derivatives of cholesterol, have been shown to cause programmed cell death in a variety of cell types. Using N9 microglia, this study was designed to investigate the molecular events induced by cholesterol oxides prior to the execution of programmed cell death.
        
        
          Results
          Microglia were very sensitive to 25-OH-cholesterol, such that a 2-day treatment of the cells with 5 μM 25-OH-cholesterol reduced cell viability to 5–10% of controls. There was a dose- and time-dependent increase in c-jun and phospho-c-jun levels in microglia prior to this 25-OH-cholesterol induced cell death. In contrast, 7-β-OH-cholesterol, which was relatively non-toxic to microglia, did not increase phospho-c-jun levels. Peroxisome proliferator-activated receptors (PPARs) are a group of nuclear receptors that have important roles in atherogenesis. Results from this study indicate that PPAR agonists such as 15d-PGJ2, indomethacin and WY14643 can attenuate cholesterol oxide induced c-jun activation and cell death in microglia.
        
        
          Conclusions
          Peroxisome proliferator-activated receptor agonists may be useful in future development of pharmacological agents against cholesterol oxide induced cytotoxicity.

Tags: 25-oh-cholesterol, microglial-cell-death, nih, ppar-agonists
Organization: U.S. Department of Health & Human Services
NYTD: Overview, Reflections & CCWIS Opportunities

This webinar described how Comprehensive Child Welfare Information System (CCWIS) can support program, data quality, and reporting requirements for the National Youth in Transition Database (NYTD). It provided an overview of NYTD, discussed the importance of engaging young people in decision making, and explored opportunities for improved data collection technology and case management systems.

Descriptive Audio Version

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: case, child, policy, reporting, scope
Organization: U.S. Department of Health & Human Services
Publications Using SAMHSA DataTable 1. Illicit Drug Use in the Past Month, by Age Group and State: Percentages, Annual Averages Based on 2010 and 2011 NSDUHs

This report presents State estimates for measures of past month illicit drug use based on the combined 2010 and 2011 National Surveys on Drug Use and Health (NSDUHs). Resuts are provided by age group.

Tags: illicit-drug-use, nsduh, samhsa, state-level-data, substance-use
Organization: U.S. Department of Health & Human Services
Compound 525394: 2,6-Dithiaoctane

Chemical compound data from PubChem database. IUPAC Name: 1-ethylsulfanyl-3-methylsulfanylpropane. Molecular Formula: C6H14S2. Molecular Weight: 150.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2008-2010 NSDUH National Maps of Prevalence Estimates by Substate Region

This report uses 2008 to 2010 National Survey on Drug Use and Health (NSDUH) to assess past year alcohol use disorder and illicit drug use disorder among persons aged 12 or older by 362 substate regions within the 50 States and the District of Columbia. Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). This page shows the maps by substate region.

Tags: alcohol-use-disorder, mental-health-prevalence, samhsa, substance-use-disorder, suicidal-ideation
Organization: U.S. Department of Health & Human Services
Compound 525546: 3-Methyl-1,8-bis[(trimethylsilyl)oxy]anthra-9,10-quinone

Chemical compound data from PubChem database. IUPAC Name: 3-methyl-1,8-bis(trimethylsilyloxy)anthracene-9,10-dione. Molecular Formula: C21H26O4Si2. Molecular Weight: 398.6. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
High-tech and low-tech orthopaedic surgery in Sub-Saharan Africa

Background
          Zambia's governmental health system suffers from shortage of surgical supplies and poor management skills for the sparse resources at hand. The situation has been worsened by the dual epidemics of HIV disease and tuberculosis. On the other hand the private medical sector has benefited greatly from less bureaucracy under the goverment of the Movement for Multi-party Democracy.
        
        
          Discussion
          The Zambian-Italian Orthopaedic Hospital in Lusaka is a well organized small unit providing free treatment of physically disabled children. The running costs are met from the fees charged for private consultations, supplemented by donations. State of the art surgical techniques are being used for congenital and acquired musculo-skeletal abnormalities. Last year 513 patients were operated upon free of charge and 320 operations were performed on private patients.

Tags: nih, orthopaedic-surgery, sub-saharan-africa, surgical-outcomes, zambia
Organization: U.S. Department of Health & Human Services
Compound 525085: 3beta-(Trimethylsiloxy)androst-5-ene

Chemical compound data from PubChem database. IUPAC Name: (10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl)oxy-trimethylsilane. Molecular Formula: C22H38OSi. Molecular Weight: 346.6. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Homing chemokines in rheumatoid arthritis

In about 20% of patients with rheumatoid arthritis, B and T lymphocytes recruited into the inflamed synovium are organized into complex microstructures, which resemble secondary lymphoid organs. The development of such lymphoid aggregates with germinal centers appears to contribute to the pathogenesis of the disease. Growing evidence indicates that chemokines and their receptors control the recruitment and positioning of leukocytes as well as their organization into node-like lymphoid structures. Here, we comment on recent studies highlighting the importance of chemokines in rheumatoid arthritis, in particular of B-cell-activating chemokine-1 in lymphoid neogenesis in the inflamed synovium.

Tags: chemokines, lymphoid-neogenesis, nih, rheumatoid-arthritis, synovium-inflammation
Organization: U.S. Department of Health & Human Services
Compound 528480: Docosane, 3-ethyl

Chemical compound data from PubChem database. IUPAC Name: 3-ethyldocosane. Molecular Formula: C24H50. Molecular Weight: 338.7. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Title IV-E Foster Care Eligibility Reviews 2020 Schedule

Postponement of the Title IV-E Foster Care Eligibility Reviews

The Children's Bureau has indefinitely postponed the Title IV-E Foster Care Eligibility Reviews due to the COVID-19 pandemic. Following the PDF link to the schedule below is a link to a letter announcing the postponement sent on April 10, 2020, from Associate Commissioner Jerry Milner to child welfare leaders.

Letter from Associate Commissioner Jerry Milner

Browse All COVID-19 Resources

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: 19, assessment, compliance, foster, policy
Organization: U.S. Department of Health & Human Services
2022 Uniform Reporting System (URS) Table For California

This is the 2022 Uniform Reporting System (URS) Output Tables for California. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: california, mental-health-services, national-outcome-measures, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
Calcium-mediated transductive systems and functionally active gap junctions in astrocyte-like GL15 cells

Background
          It has been proposed that GL15, a human cell line derived from glioblastoma multiforme, is a possible astroglial-like cell model, based on the presence of cytoplasmic glial fibrillary acidic protein.
        
        
          Results
          The aim of this work was to delineate the functional characteristics of GL15 cells using various experimental approaches, including the study of morphology, mechanism of induction of intracellular Ca2+ increase by different physiological agonists, and the presence and permeability of the gap-junction system during cell differentiation.
          Immunostaining experiments showed the presence and localization of specific glial markers, such as glial fibrillary acidic protein and S100B, and the lack of the neuronal marker S100A. Notably, all the Ca2+ pathways present in astrocytes were detected in GL15 cells. In particular, oscillations in intracellular Ca2+ levels were recorded either spontaneously, or in the presence of ATP or glutamate (but not KCl).
          Immunolabelling assays and confocal microscopy, substantiated by Western blot analyses, revealed the presence of connexin43, a subunit of astrocyte gap-junction channels. The protein is organised in characteristic spots on the plasma membrane at cell-cell contact regions, and its presence and distribution depends on the differentiative status of the cell. Finally, a microinjection/dye-transfer assay, employed to determine gap-junction functionality, clearly demonstrated that the cells were functionally coupled, albeit to varying degrees, in differentiated and undifferentiated phenotypes.
        
        
          Conclusions
          In conclusion, results from this study support the use of the GL15 cell line as a suitable in vitro astrocyte model, which provides a valuable guide for studying glial physiological features at various differentiation phases.

Tags: astrocyte-model, calcium-signaling, gap-junctions, glioblastoma-cells, nih
Organization: U.S. Department of Health & Human Services
Denver: Drug-Related Emergency Department Visits, 2004-2011 - All Visits

Excel file with estimates, rates, relative standard errors, trends and confidence intervals for all drug-related emergency department (ED) visits in the Denver metropolitan area, covering 2004-2011. File includes all drug-related ED visits that are reportable to DAWN without regard for the reason for the visit or the specific drugs involved. It includes visits involving all forms of drug misuse or abuse plus visits resulting from adverse reaction, accidental ingestion, suicide attempts, and visits where patients were seeking detoxification services. These estimates are useful for looking at overall levels of drug involvement in ED visits.File includes data for over 500 drugs, including illicit drugs, prescription and over-the-counter medications, dietary supplements, inhalants and alcohol.  Includes total visits, gender, age group, race/ethnicity, outcome of visit, drug combinations, number of drugs involved in visit, drug frequency, and drugs confirmed by toxicology.Additional detail is provided for illicit drugs, psychotherapeutic drugs, central nervous system (CNS) drugs, respiratory drugs and cardiovascular drugs.

Tags: dawn-data, drug-related-ed-visits, emergency-department-data, samhsa, substance-abuse-trends
Organization: U.S. Department of Health & Human Services
American Indian and Alaska Native Substance Abuse Treatment Admissions Are More Likely Than Other Admissions to Report Alcohol Abuse

This is a Treatment Episode Data Set (TEDS) report on American Indians and Alaska Native (AI/AN) admissions to substance abuse treatment facilities and their alcohol use.

Tags: alcohol-abuse, american-indian-alaska-native, samhsa, substance-abuse-treatment, teds-data
Organization: U.S. Department of Health & Human Services
2021 Uniform Reporting System (URS) Table For Palau

This is the 2021 Uniform Reporting System (URS) Output Tables for Palau. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, national-outcome-measures, palau-mental-health, samhsa
Organization: U.S. Department of Health & Human Services
Long-term outcome after coronary stenting

The present review assesses the data on long-term outcome after coronary stenting. Histological, angiographical and intravascular imaging data have shown that the insertion of stents constitutes only a transient stimulus to lumen renarrowing, that this process is almost complete at 6 months and that a certain degree of neointima regression is also possible after this time. Clinical data have confirmed the sustained benefit of stenting in the long term. Careful selection of optimal stent designs and application of the recent advances in adjunctive pharmacological therapy are currently effective strategies to improve both short-and long-term results with coronary stenting. However, further efforts are needed and are ongoing to combat restenosis, a process that counters the excellent short-term results of stenting in the long term.

Tags: cardiovascular-disease, coronary-stenting, long-term-outcomes, nih, restenosis
Organization: U.S. Department of Health & Human Services
Genetic markers of osteoarticular disorders: facts and hopes

Osteoarthritis and osteoporosis are the two most common age-related chronic disorders of articular joints and skeleton, representing a major public health problem in most developed countries. Apart from being influenced by environmental factors, both disorders have a strong genetic component, and there is now considerable evidence from large population studies that these two disorders are inversely related. Thus, an accurate analysis of the genetic component of one of these two multifactorial diseases may provide data of interest for the other. However, the existence of confounding factors must always be borne in mind in interpreting the genetic analysis. In addition, each patient must be given an accurate clinical evaluation, including family history, history of drug treatments, lifestyle, and environment, in order to reduce the background bias. Here, we review the impact of recent work in molecular genetics suggesting that powerful molecular biology techniques will soon make possible both a rapid accumulation of data on the genetics of both disorders and the development of novel diagnostic, prognostic, and therapeutic approaches.

Tags: genetic-markers, nih, osteoarthritis-genetics, osteoarticular-disorders, osteoporosis-genetics
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: California, 2015

This is a behavioral health report for the state of California. The report utilizes data from the National Survey on Drug Use and Health (NSDUH), and the Uniform Reporting System. The topics addressed in the report include youth substance use, youth mental health and treatment, mental health and treatment, substance use and substance use treatment.

Tags: california-behavioral-health, mental-health-treatment, samhsa, substance-use-treatment, youth-substance-use
Organization: U.S. Department of Health & Human Services
Organization specific predictors of job satisfaction: findings from a Canadian multi-site quality of work life cross-sectional survey

Background
          Organizational features can affect how staff view their quality of work life. Determining staff perceptions about quality of work life is an important consideration for employers interested in improving employee job satisfaction. The purpose of this study was to identify organization specific predictors of job satisfaction within a health care system that consisted of six independent health care organizations.
        
        
          Methods
          5,486 full, part and causal time (non-physician) staff on active payroll within six organizations (2 community hospitals, 1 community hospital/long-term care facility, 1 long-term care facility, 1 tertiary care/community health centre, and 1 visiting nursing agency) located in five communities in Central West Ontario, Canada were asked to complete a 65-item quality of work life survey. The self-administered questionnaires collected staff perceptions of: co-worker and supervisor support; teamwork and communication; job demands and decision authority; organization characteristics; patient/resident care; compensation and benefits; staff training and development; and impressions of the organization. Socio-demographic data were also collected.
        
        
          Results
          Depending on the organization, between 15 and 30 (of the 40 potential predictor) variables were found to be statistically associated with job satisfaction (univariate analyses). Logistic regression analyses identified the best predictors of job satisfaction and these are presented for each of the six organizations and for all organizations combined.
        
        
          Conclusions
          The findings indicate that job satisfaction is a multidimensional construct and although there appear to be some commonalities across organizations, some predictors of job satisfaction appear to be organization and context specific.

Tags: healthcare-workers, job-satisfaction, nih, organizational-predictors, quality-of-work-life
Organization: U.S. Department of Health & Human Services
Treatment Episode Data Set (TEDS): 1992-1995, National Admissions to Substance Abuse Treatment Services

This report presents data from the Treatment Episode Data Set (TEDS) for 1995, and trend data for 1992 to 1995. The report provides information on the demographic and substance abuse characteristics of people aged 12 and older admitted to treatment for abuse of alcohol and/or drugs in facilities that report to individual state administrative data systems.

Tags: alcohol-drug-abuse, samhsa, substance-abuse-treatment, teds-data, treatment-admissions
Organization: U.S. Department of Health & Human Services
Identification of four families of yCCR4- and Mg

Background
          The yeast yCCR4 factor belongs to the CCR4-NOT transcriptional regulatory complex, in which it interacts, through its leucine-rich repeat (LRR) motif with yPOP2. Recently, yCCR4 was shown to be a component of the major cytoplasmic mRNA deadenylase complex, and to contain a fold related to the Mg2+-dependent endonuclease core.
        
        
          Results
          Here, we report the identification of nineteen yCCR4-related proteins in eukaryotes (including yeast, plants and animals), which all contain the yCCR4 endonuclease-like fold, with highly conserved CCR4-specific residues. Phylogenetic and genomic analyses show that they form four distinct families, one of which contains the yCCR4 orthologs. The orthologs in animals possess a leucine-rich repeat domain. We show, using two-hybrid and far-Western assays, that the human member binds to the human yPOP2 homologs, i.e. hCAF1 and hPOP2, in a LRR-dependent manner.
        
        
          Conclusions
          We have identified the mammalian orthologs of yCCR4 and have shown that the human member binds to the human yPOP2 homologs, thus strongly suggesting conservation of the CCR4-NOT complex from yeast to human. All members of the four identified yCCR4-related protein families show stricking conservation of the endonuclease-like catalytic motifs of the yCCR4 C-terminal domain and therefore constitute a new family of potential deadenylases in mammals.

Tags: endonuclease-activity, mrna-deadenylase, nih, transcriptional-regulation, yccr4-protein
Organization: U.S. Department of Health & Human Services