AndreaBozzo/ceres-open-data-index huggingface dataset:
Publications Using SAMHSA Data2016 Uniform Reporting System (URS) Table for Maryland

This is the 2016 Uniform Reporting System (URS) Output Tables for Maryland. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: maryland-mental-health, mental-health-services, national-outcome-measures, samhsa, urs-data
Organization: U.S. Department of Health & Human Services
The DAWN Report: Update on Emergency Department Visits Involving Energy Drinks: A Continuing Public Health Concern

This Drug Abuse Warning Network (DAWN) short report is about emergency department visits involving energy drinks (beverages containing caffeine and vitamins/minerals) from 2007 to 2011.

Tags: adverse-events, caffeine-toxicity, emergency-department, energy-drinks, samhsa
Organization: U.S. Department of Health & Human Services
2020 Uniform Reporting System (URS) Table For Missouri

This is the 2020 Uniform Reporting System (URS) Output Tables for Missouri. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-data, mental-health-services, missouri, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Linkage analysis of HLA and candidate genes for celiac disease in a North American family-based study

Background
          Celiac disease has a strong genetic association with HLA. However, this association only explains approximately half of the sibling risk for celiac disease. Therefore, other genes must be involved in susceptibility to celiac disease. We tested for linkage to genes or loci that could play a role in pathogenesis of celiac disease.
        
        
          Methods
          DNA samples, from members of 62 families with a minimum of two cases of celiac disease, were genotyped at HLA and at 13 candidate gene regions, including CD4, CTLA4, four T-cell receptor regions, and 7 insulin-dependent diabetes regions. Two-point and multipoint heterogeneity LOD (HLOD) scores were examined.
        
        
          Results
          The highest two-point and multipoint HLOD scores were obtained in the HLA region, with a two-point HLOD of 3.1 and a multipoint HLOD of 5.0. For the candidate genes, we found no evidence for linkage.
        
        
          Conclusions
          Our significant evidence of linkage to HLA replicates the known linkage and association of HLA with CD. In our families, likely candidate genes did not explain the susceptibility to celiac disease.

Tags: celiac-disease, family-based-study, genetic-association, hla-linkage, nih
Organization: U.S. Department of Health & Human Services
High-resolution physical map for chromosome 16q12.1-q13, the Blau syndrome locus

Background
          The Blau syndrome (MIM 186580), an autosomal dominant granulomatous disease, was previously mapped to chromosome 16p12-q21. However, inconsistent physical maps of the region and consequently an unknown order of microsatellite markers, hampered us from further refining the genetic locus for the Blau syndrome. To address this problem, we constructed our own high-resolution physical map for the Blau susceptibility region.
        
        
          Results
          We generated a high-resolution physical map that provides more than 90% coverage of a refined Blau susceptibility region. The map consists of four contigs of sequence tagged site-based bacterial artificial chromosomes with a total of 124 bacterial artificial chromosomes, and spans approximately 7.5 Mbp; however, three gaps still exist in this map with sizes of 425, 530 and 375 kbp, respectively, estimated from radiation hybrid mapping.
        
        
          Conclusions
          Our high-resolution map will assist genetic studies of loci in the interval from D16S3080, near D16S409, and D16S408 (16q12.1 to 16q13).

Tags: blau-syndrome, chromosome-16, genetic-mapping, granulomatous-disease, nih
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Maine, 2015

This is a behavioral health report for the state of Maine. The report utilizes data from the National Survey on Drug Use and Health (NSDUH), and the Uniform Reporting System. The topics addressed in the report include youth substance use, youth mental health and treatment, mental health and treatment, substance use and substance use treatment.

Tags: maine-behavioral-health, mental-health-treatment, nsduh-data, samhsa, youth-substance-use
Organization: U.S. Department of Health & Human Services
2020 Uniform Reporting System (URS) Table For South Dakota

This is the 2020 Uniform Reporting System (URS) Output Tables for South Dakota. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-data, mental-health-services, noms-measures, samhsa, south-dakota
Organization: U.S. Department of Health & Human Services
Compound 527385: 22,26-Dimethyl-triacontyl cyanide

Chemical compound data from PubChem database. IUPAC Name: 23,27-dimethylhentriacontanenitrile. Molecular Formula: C33H65N. Molecular Weight: 475.9. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Use of the direct puncture technique in management of capillaro-venous malformations: case report

Background
          Preoperative devascularization of the capillaro-venous malformations located in the aero-digestive tract is important for surgeons, to minimize blood loss during surgical excision of malformations.
        
        
          Case presentation
          Here we present two cases of capillaro-venous malformation in which we could successfully achieve preoperative devascularization, by directly injecting n-butyl cyano acrylate into the capillaro-venous bed. This technique is relatively easy, safe and cheap, and can be carried out immediately before surgery.

Tags: capillaro-venous-malformation, devascularization, direct-puncture, n-butyl-cyanoacrylate, nih
Organization: U.S. Department of Health & Human Services
An MCASE approach to the search of a cure for Parkinson's Disease.

Background
          Parkinson's disease is caused by a dopamine deficiency state in the fore brain area. Dopamine receptor agonists, MAO-B inhibitors, and N-Methyl-D-Aspartate (NMDA) receptor antagonists are known to have antiparkinson effect. Levodopa, a dopamine structural analog, is the best currently available medication for the treatment of Parkinsons disease. Unfortunately, it also induces side effects upon long administration time. Thus, multidrug therapy is often used, in which various adjuvants alleviate side effects of levodopa and enhance its antiparkinsonian action.
        
        
          Results
          Computer models have been created for three known antiparkinson mechanisms using the MCASE methodology. New drugs for Parkinsons disease can be designed on the basis of these models. We also speculate that the presence of biophores belonging to different groups can be beneficial and designed some potential drugs along this line. The proposed compounds bear pharmacophores of MAO-B inhibitors, dopamine agonists and NMDA antagonists, which could synergistically enhance their antiparkinson effect.
        
        
          Conclusions
          The methodology could readily be expanded to other endpoints where drugs with multiple activity mechanisms would be desirable.

Tags: dopamine-agonists, drug-discovery, mcase-modeling, nih, parkinsons-disease
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Delaware, 2014

This is a behavioral health report for the state of Delaware. It uses the National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment Services (NSSATS) to address the topics of youth substance use, youth mental health and treatment, adult mental health and treatment, substance use, and substance use treatment for the years 2009 to 2013.

Tags: adult-mental-health, delaware-behavioral-health, samhsa, substance-abuse-treatment, youth-substance-use
Organization: U.S. Department of Health & Human Services
Debate: A subversive view of subsets - a dissident clinician's opinion

Clinical trialists and statisticians are very wary of subgroup analysis, for good reasons. Clinicians have to deal with situations in which subgroups of patients differ widely from one another in their prognosis and response to treatment. Few trials are large enough to demonstrate convincingly these differences in outcome, but often provide suggestive evidence. Should we ignore this and treat all patients as the same, or should we allow dubious statistical evidence to buttress biological plausibility in making clinical decisions?

Tags: clinical-trials, myocardial-infarction, nih, subgroup-analysis, treatment-outcomes
Organization: U.S. Department of Health & Human Services
2020 Uniform Reporting System (URS) Table For Idaho

This is the 2020 Uniform Reporting System (URS) Output Tables for Idaho. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, national-outcome-measures, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
Compound 525279: N'-Cyclohexyl-N,N-dimethyl-acetamidine

Chemical compound data from PubChem database. IUPAC Name: N'-cyclohexyl-N,N-dimethylethanimidamide. Molecular Formula: C10H20N2. Molecular Weight: 168.28. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
A cohort study of possible risk factors for over-reporting of antihypertensive adherence

Background
          The identification of poor medicinal adherence is difficult because direct observation of medication use is usually impractical. Up to 50% of individuals on chronic therapies may not be taking their medication as prescribed. This study is one of the first to explore possible risk factors for over-reporting of antihypertensive adherence using electronic medication monitoring.
        
        
          Methods
          The adherence of 286 individuals on single-drug antihypertensive therapy in a large managed care organization was electronically monitored for approximately three months. Questionnaires on socioeconomic background, adherence to therapy, health beliefs, and social support before and after adherence monitoring were completed. Over-reporting of antihypertensive adherence was assessed by comparing the self-reported frequency of noncompliance with that determined from electronic dosing records. Risk factors for over-reporting were identified by contingency table analysis and step-wise logistic regression.
        
        
          Results
          Although only 21% of participants acknowledged missing doses on one or more days per week, electronic monitoring documented nonadherence at this or a higher level in 42% of participants. The following variables were associated with over-reporting: >1 versus 1 daily dose (OR = 2.58; 95% CI = 1.50–4.41; p = .0006), lower perceived health risk from nonadherence (OR = 1.35; 95% CI = 1.10–1.64; p = .0035), and annual household income of <$15,000 versus >$30,000 (OR = 2.64; 95% CI = 1.13–6.18; p = .025).
        
        
          Conclusions
          Over-reporting of adherence may be affected by factors related to dosing frequency, health beliefs and socioeconomic status. This topic deserves further investigation in other patient populations to elucidate possible underlying behavioral explanations.

Tags: antihypertensive-adherence, electronic-monitoring, medication-adherence, nih, over-reporting-bias
Organization: U.S. Department of Health & Human Services
T-cell-mediated control of autoimmunity

Inflammatory responses provoked by pathogens are antigen-specific in their induction but are nonspecific in their effects. Consequently, they are potentially damaging to the host that produces them. In addition, the immune system can respond specifically to self antigens, thereby giving rise to autoimmune diseases. A number of regulatory mechanisms have evolved to prevent such adverse effects. One of these has been shown to depend on a particular subset of CD4+ T cells that appears to have evolved specifically for this protective role. These cells are termed regulatory T cells. This review summarises what is known about them.

Tags: autoimmune-diseases, cd4-t-cells, inflammatory-response, nih, t-cell-regulation
Organization: U.S. Department of Health & Human Services
Louisiana (LA)

This report uses 2008 to 2010 National Survey on Drug Use and Health (NSDUH) to assess past year alcohol use disorder and illicit drug use disorder among persons aged 12 or older for Louisiana overall and for substate regions within Louisiana. Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE).

Tags: louisiana-health, mental-health-indicators, nsduh-data, samhsa, substance-use-disorder
Organization: U.S. Department of Health & Human Services
Minneapolis: Drug-Related Emergency Department Visits, 2004-2011 - All Visits

Excel file with estimates, rates, relative standard errors, trends and confidence intervals for all drug-related emergency department (ED) visits in the Minneapolis metropolitan area, covering 2004-2011. File includes all drug-related ED visits that are reportable to DAWN without regard for the reason for the visit or the specific drugs involved. It includes visits involving all forms of drug misuse or abuse plus visits resulting from adverse reaction, accidental ingestion, suicide attempts, and visits where patients were seeking detoxification services. These estimates are useful for looking at overall levels of drug involvement in ED visits.File includes data for over 500 drugs, including illicit drugs, prescription and over-the-counter medications, dietary supplements, inhalants and alcohol.  Includes total visits, gender, age group, race/ethnicity, outcome of visit, drug combinations, number of drugs involved in visit, drug frequency, and drugs confirmed by toxicology.Additional detail is provided for illicit drugs, psychotherapeutic drugs, central nervous system (CNS) drugs, respiratory drugs and cardiovascular drugs.

Tags: drug-related-ed-visits, emergency-department-data, minneapolis-health-data, samhsa, substance-abuse-trends
Organization: U.S. Department of Health & Human Services
National Survey of Substance Abuse Treatment Services (N-SSATS): 2007 Data on Substance Abuse Treatment Facilities

This report presents results from the 2007 National Survey of Substance Abuse Treatment Services (N-SSATS), an annual census of facilities providing substance abuse treatment. Conducted by the Substance Abuse and Mental Health Services Administration (SAMHSA), the N-SSATS is designed to collect data on the location, characteristics, and use of alcoholism and drug abuse treatment facilities and services throughout the 50 states, the District of Columbia, and other U.S. jurisdictions.

Tags: alcoholism-treatment, drug-abuse-treatment, samhsa, substance-abuse-treatment, treatment-facilities
Organization: U.S. Department of Health & Human Services
Compound 528363: 2,4,6-Trimethyl-1,3,5-thiadiazinane

Chemical compound data from PubChem database. IUPAC Name: 2,4,6-trimethyl-1,3,5-thiadiazinane. Molecular Formula: C6H14N2S. Molecular Weight: 146.26. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 525106: 2,3-Dichloropropyl decanoate

Chemical compound data from PubChem database. IUPAC Name: 2,3-dichloropropyl decanoate. Molecular Formula: C13H24Cl2O2. Molecular Weight: 283.2. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Colorado (CO)

This report uses 2008 to 2010 National Survey on Drug Use and Health (NSDUH) to assess past year alcohol use disorder and illicit drug use disorder among persons aged 12 or older for Colorado overall and for substate regions within Colorado. Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE).

Tags: colorado-health, mental-health-indicators, nsduh-data, samhsa, substance-use-disorder
Organization: U.S. Department of Health & Human Services
Connexin-mimetic peptide Gap 27 decreases osteoclastic activity

Background
          Bone remodelling is dependent on the balance between bone resorbing osteoclasts and bone forming osteoblasts. We have shown previously that osteoclasts contain gap-junctional protein connexin-43 and that a commonly used gap-junctional inhibitor, heptanol, can inhibit osteoclastic bone resorption. Since heptanol may also have some unspecific effect unrelated to gap-junctional inhibition we wanted to test the importance of gap-junctional communication to osteoclasts using a more specific inhibitor.
        
        
          Methods
          A synthetic connexin-mimetic peptide, Gap 27, was used to evaluate the contribution of gap-junctional communication to osteoclastic bone resorption. We utilised the well-characterised pit-formation assay to study the effects of the specific gap-junctional inhibitor to the survival and activity of osteoclasts.
        
        
          Results
          Gap 27 caused a remarked decrease in the number of both TRAP-positive mononuclear and multinucleated rat osteoclasts cultured on bovine bone slices. The decrease in the cell survival seemed to be restricted to TRAP-positive cells, whereas the other cells of the culture model seemed unaffected. The activity of the remaining osteoclasts was found to be diminished by measuring the percentage of osteoclasts with actin rings of all TRAP-positive cells. In addition, the resorbed area in the treated cultures was greatly diminished.
        
        
          Conclusions
          On the basis of these results we conclude that gap-junctional communication is essential for the action of bone resorbing osteoclasts and for proper remodelling for bone.

Tags: bone-resorption, connexin-43, gap-junctional-communication, nih, osteoclast-activity
Organization: U.S. Department of Health & Human Services
2007 CMHS Uniform Reporting System Output Tables

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2007. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant, mental-health-services, outcome-measures, samhsa, state-mental-health
Organization: U.S. Department of Health & Human Services
2022 Uniform Reporting System (URS) Table For District of Colombia

This is the 2022 Uniform Reporting System (URS) Output Tables for District of Colombia. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, national-outcome-measures, samhsa, substance-abuse-mental-health
Organization: U.S. Department of Health & Human Services
Impaired wound healing in mice deficient in a matricellular protein SPARC (osteonectin, BM-40)

Background
          SPARC is a matricellular protein involved in cell-matrix interactions. From expression patterns at the wound site and in vitro studies, SPARC has been implicated in the control of wound healing. Here we examined the function of SPARC in cutaneous wound healing using SPARC-null mice and dermal fibroblasts derived from them.
        
        
          Results
          In large (25 mm) wounds, SPARC-null mice showed a significant delay in healing as compared to wild-type mice (31 days versus 24 days). Granulation tissue formation and extracellular matrix protein production were delayed in small 6 mm SPARC-null wounds initially but were resolved by day 6. In in vitro wound-healing assays, while wild-type primary dermal fibroblasts showed essentially complete wound closure at 11 hours, wound closure of SPARC-null cells was incomplete even at 31 hours. Addition of purified SPARC restored the normal time course of wound closure. Treatment of SPARC-null cells with mitomycin C to analyze cell migration without cell proliferation showed that wound repair remained incomplete after 31 hours. Cell proliferation as measured by 3H-thymidine incorporation and collagen gel contraction by SPARC-null cells were not compromised.
        
        
          Conclusions
          A significant delay in healing large excisional wounds and setback in granulation tissue formation and extracellular matrix protein production in small wounds establish that SPARC is required for granulation tissue formation during normal repair of skin wounds in mice. A defect in wound closure in vitro indicates that SPARC regulates cell migration. We conclude that SPARC plays a role in wound repair by promoting fibroblast migration and thus granulation tissue formation.

Tags: fibroblast-function, mouse-model, nih, sparck-protein, wound-healing
Organization: U.S. Department of Health & Human Services
2019 Uniform Reporting System (URS) Table for Massachusetts

These are the 2019 Uniform Reporting System (URS) Output Tables for Massachusetts. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, massachusetts, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services