AndreaBozzo/ceres-open-data-index huggingface dataset:
Kentucky (KY)

This report presents Kentucky\'s estimates for 25 measures of substance use and mental health based on the combined 2009 and 2010 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for Kentucky for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: kentucky-nsduh, mental-health, samhsa, serious-mental-illness, substance-use
Organization: U.S. Department of Health & Human Services
Compound 525614: N,N-Dimethyl-N'-butyl-benzamidine

Chemical compound data from PubChem database. IUPAC Name: N'-butyl-N,N-dimethylbenzenecarboximidamide. Molecular Formula: C13H20N2. Molecular Weight: 204.31. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Structure of coronavirus main proteinase reveals combination of a chymotrypsin fold with an extra α-helical domain

The key enzyme in coronavirus polyprotein processing is the viral main proteinase, Mpro, a protein with extremely low sequence similarity to other viral and cellular proteinases. Here, the crystal structure of the 33.1 kDa transmissible gastroenteritis (corona)virus Mpro is reported. The structure was refined to 1.96 Å resolution and revealed three dimers in the asymmetric unit. The mutual arrangement of the protomers in each of the dimers suggests that Mpro self-processing occurs in trans. The active site, comprised of Cys144 and His41, is part of a chymotrypsin-like fold that is connected by a 16 residue loop to an extra domain featuring a novel α-helical fold. Molecular modelling and mutagenesis data implicate the loop in substrate binding and elucidate S1 and S2 subsites suitable to accommodate the side chains of the P1 glutamine and P2 leucine residues of Mpro substrates. Interactions involving the N-terminus and the α-helical domain stabilize the loop in the orientation required for trans-cleavage activity. The study illustrates that RNA viruses have evolved unprecedented variations of the classical chymotrypsin fold.

Tags: chymotrypsin-fold, coronavirus-mpro, nih, protein-structure, viral-proteinase
Organization: U.S. Department of Health & Human Services
2012 Uniform Reporting System (URS) Tables for Tennessee

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2012. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, outcome-measures, samhsa, urs-data
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: New York, 2014

This is a behavioral health report for the state of New York. It uses the  National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment Services (NSSATS) to address the topics of youth substance use , youth mental health and treatment, adult mental health and treatment, substance use, substance use treatment, and medicare enrollees for the years 2009 to 2013.

Tags: behavioral-health, mental-health, samhsa, substance-use, youth-mental-health
Organization: U.S. Department of Health & Human Services
Expression of cytokine and chemokine mRNA and secretion of tumor necrosis factor-α by gallbladder epithelial cells: Response to bacterial lipopolysaccharides

Background
          In addition to immune cells, many other cell types are known to produce cytokines. Cultured normal mouse gallbladder epithelial cells, used as a model system for gallbladder epithelium, were examined for their ability to express the mRNA of various cytokines and chemokines in response to bacterial lipopolysaccharide. The synthesis and secretion of the tumor necrosis factor-α (TNF-α) protein by these cells was also measured.
        
        
          Results
          Untreated mouse gallbladder cells expressed mRNA for TNF-α, RANTES, and macrophage inflammatory protein-2 (MIP-2). Upon treatment with lipopolysaccharide, these cells now produced mRNA for Interleukin-1β (IL-1β), IL-6, monocyte chemoattractant protein-1 (MCP-1), and showed increased expression of TNF-α and MIP-2 mRNA. Untreated mouse gallbladder cells did not synthesize TNF-α protein; however, they did synthesize and secrete TNF-α upon treatment with lipopolysaccharide.
        
        
          Methods
          Cells were treated with lipopolysaccharides from 3 strains of bacteria. Qualitative and semi-quantitative RT-PCR, using cytokine or chemokine-specific primers, was used to measure mRNA levels of TNFα, IL-1β, IL-6, IL-10, KC, RANTES, MCP-1, and MIP-2. TNF-α protein was measured by immunoassays.
        
        
          Conclusion
          This research demonstrates that gallbladder epithelial cells in response to lipopolysaccharide exposure can alter their cytokine and chemokine RNA expression pattern and can synthesize and secrete TNFα protein. This suggests a mechanism whereby gallbladder epithelial cells in vivo may mediate gallbladder secretory function, inflammation and diseases in an autocrine/paracrine fashion by producing and secreting cytokines and/or chemokines during sepsis.

Tags: cytokine-expression, gallbladder-epithelial-cells, lipopolysaccharide-response, nih, tnf-alpha
Organization: U.S. Department of Health & Human Services
Iowa 2016 Potential Areas for Addressing Service Gaps for Opioid Treatment

The purpose of the medication-assisted treatment (MAT) facility maps is to identify areas on a state-by-state basis that may be potentially underserved by existing treatment facilities. The maps are created with a methodology that seeks to include the highest potential need areas from individual counties so that county-level stakeholders are also informed. The maps are meant to be used as a tool for policy makers to determine potentially underserved areas—not as a definitive representation of these areas.

Tags: iowa-opioids, mat-access, opioid-treatment, samhsa, service-gap-analysis
Organization: U.S. Department of Health & Human Services
2016 Uniform Reporting System (URS) Table for Rhode Island

This is the 2016 Uniform Reporting System (URS) Output Tables for Rhode Island. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-program, mental-health-services, national-outcome-measures, rhode-island, samhsa
Organization: U.S. Department of Health & Human Services
2013 CMHS Uniform Reporting System (URS) Table for North Dakota

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Tables for North Dakota for 2013. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program.  State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, north-dakota, outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Plasma lipases and lipid transfer proteins increase phospholipid but not free cholesterol transfer from lipid emulsion to high density lipoproteins.

Background
          Plasma lipases and lipid transfer proteins are involved in the generation and speciation of high density lipoproteins. In this study we have examined the influence of plasma lipases and lipid transfer protein activities on the transfer of free cholesterol (FC) and phospholipids (PL) from lipid emulsion to human, rat and mouse lipoproteins. The effect of the lipases was verified by incubation of labeled (3H-FC,14C-PL) triglyceride rich emulsion with human plasma (control, post-heparin and post-heparin plus lipase inhibitor), rat plasma (control and post-heparin) and by the injection of the labeled lipid emulsion into control and heparinized functionally hepatectomized rats.
        
        
          Results
          In vitro, the lipase enriched plasma stimulated significantly the transfer of 14C-PL from emulsion to high density lipoprotein (p<0.001) but did not modify the transfer of 3H-FC. In hepatectomized rats, heparin stimulation of intravascular lipolysis increased the plasma removal of 14C-PL and the amount of 14C-PL found in the low density lipoprotein density fraction but not in the high density lipoprotein density fraction. The in vitro and in vivo experiments showed that free cholesterol and phospholipids were transferred from lipid emulsion to plasma lipoproteins independently from each other. The incubation of human plasma, control and control plus monoclonal antibody anti-cholesteryl ester transfer protein (CETP), with 14C-PL emulsion showed that CETP increases 14C-PL transfer to human HDL, since its partial inhibition by the anti-CETP antibody reduced significantly the 14C-PL transfer (p<0.05). However, comparing the nontransgenic (no CETP activity) with the CETP transgenic mouse plasma, no effect of CETP on the 14C-PL distribution in mice lipoproteins was observed.
        
        
          Conclusions
          It is concluded that: 1-intravascular lipases stimulate phospholipid transfer protein mediated phospholipid transfer, but not free cholesterol, from triglyceride rich particles to human high density lipoproteins and rat low density lipoproteins and high density lipoproteins; 2-free cholesterol and phospholipids are transferred from triglyceride rich particles to plasma lipoproteins by distinct mechanisms, and 3 - CETP also contributes to phospholipid transfer activity in human plasma but not in transgenic mice plasma, a species which has high levels of the specific phospholipid transfer protein activity.

Tags: high-density-lipoproteins, lipid-transfer, nih, phospholipid-transfer, plasma-lipases
Organization: U.S. Department of Health & Human Services
Table 6. 2011-2012 NSDUH Illicit Drug Use Other Than Marijuana in the Past Month, by Age Group and State

Table 6. Illicit Drug Use Other Than Marijuana in the Past Month, by Age Group and State: Percentages, Annual Averages Based on 2011 and 2012 NSDUHs. Results are provided by State and for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: drug-prevalence, illicit-drug-use, nsduh-data, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
2011 State Profile — South Dakota

This is a National Survey of Substance Abuse Treatment Services (N-SSATS) data table showing state profiles for South Dakota in 2011. N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 States, the District of Columbia, and other U.S. jurisdictions.

Tags: n-ssats, samhsa, south-dakota, substance-abuse-treatment, treatment-facilities
Organization: U.S. Department of Health & Human Services
Compound 525628: N,N-Dimethyl-N'-heptyl-p-methoxybenzamidine

Chemical compound data from PubChem database. IUPAC Name: N'-heptyl-4-methoxy-N,N-dimethylbenzenecarboximidamide. Molecular Formula: C17H28N2O. Molecular Weight: 276.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
IT Modernization and Agile Processes

How can the agile software development process be extended to procurement and contracting?

In an effort to replace its aging statewide child welfare information system, the State of California is making the transition to an agile software development approach. To support this effort, the State will no longer issue the traditional single, large request for proposal (RFP) for a monolithic system procurement. Instead, with the goal of saving time and money, the State has chosen to use an agile procurement approach by issuing a series of smaller RFPs to promote modular, sequential development. The State developed this new approach with the assistance of the Administration of Children, Youth, and Families (ACYF) and 18F, the innovative consulting arm of the General Services Administration (GSA). The State has already released two fast-track RFPs with contract awards expected in April or May.

Rafael López, ACYF commissioner, and other Federal personnel will discuss the advantages and opportunities provided through this new approach to how systems are procured. California staff will provide an overview of what is happening as they move forward with their IT modernization using this agile procurement approach.

Speakers presenting at this webinar include the following:

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: agile, child, policy, public, scope
Organization: U.S. Department of Health & Human Services
New Hampshire (NH)

This report presents New Hampshire\'s estimates for 25 measures of substance use and mental health based on the combined 2009 and 2010 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for New Hampshire for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: ami-smi-mde, mental-health, nh-survey, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Runaway and Homeless Youth Management Information System (1992-1995)

It is estimated that over a million young people run away or become homeless each year.  These youth face increasingly complex issues, including substance abuse, physical and sexual abuse, and AIDS.  The serious issues faced by these youths are coupled with funding constraints among almost all agencies providing services to this population.  In 1974 the Family and Youth Services Bureau (FYSB) authorized funding to assist community based programs to serve youth who were not otherwise being served by traditional human service agencies. The funding was used for the operation of basic center programs which would provide support for runaway and homeless youth (RHY).  The programs offered emergency shelter, crisis intervention services, and family reunification services.   In 1988 the Transitional Living Program was introduced in order to provide services to older youth requiring assistance in becoming self-sufficient. While helping to support at-risk youth, the FYSB laws also mandate that certain data be regularly collected and reported. For example, FYSB supported agencies must report on the profile of the youth and families they serve, and provide an overview of the services which they deliver under their grant programs.  In order to assist these grantees in their reporting responsibilities, FYSB funded the development of a Runaway and Homeless Youth Management Information System (RHY MIS).   The RHY MIS was designed to provide comprehensive information on youth served, services provided, and programs which provide the services.The RHY MIS was designed, developed, and implemented by Information Technology International (ITI). Gradual implementation of the MIS began in 1992 with approximately 400 RHY grantee sites across the country. By 1995, virtually all existing grant programs had at least one staff member who had been trained and grantees were expected to use the MIS and submit data to FYSB on a quarterly basis.The fiscal year 1992-1995 RHY MIS dataset contains data submitted during the federal fiscal years 1992-1995.  Data are included from participating agencies in 53 US States and Territories.  The dataset includes one file which contains 93389 observations and 490 variables.  Variables pertaining to youth demographics, problems and services are provided.

Investigators: Diepenbrock, Elaine

Tags: abuse, care, ndacan, policy, reporting
Organization: U.S. Department of Health & Human Services
Results from the 2015 National Survey on Drug Use and Health:  Detailed Tables

Results from the 2015 National Survey on Drug Use and Health: Detailed Tables is a collection of tables presenting national estimates from the National Survey on Drug Use and Health (NSDUH). These tables present information on drug, alcohol, and tobacco use, as well as drug and alcohol dependence and abuse and treatment, and measures of mental health, such as major depressive episodes and serious mental illness. Measures of these behaviors and characteristics are presented by a variety of demographic, geographic, and other variables. The estimates in the tables include rates of the behaviors, numbers of persons engaging in these behaviors, and other measures. Although the majority of these tables are trend tables presenting estimates from the 2014 and 2015 NSDUHs, some tables include only estimates from the 2015 NSDUH.

Tags: alcohol-use, drug-use, mental-health, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
Incidence Tables  (Prevalence Estimates) - 4.1 to 4.16

These detailed tables present totals and prevalence estimates of substance use initiation from the 2011 National Survey on Drug Use and Health (NSDUH). Substances examined include illicit drugs (e.g., marijuana, cocaine, heroin, hallucinogens (including LSD, PCP, Ecstasy), inhalants, and the nonmedical use of prescription-type pain relievers (including OxyContin), tranquilizers, stimulants, sedatives, alcohol, and tobacco products (including cigarettes, smokeless tobacco, and cigars). Results are provided by age group and gender. Estimates are provided for both 2011 and 2010.

Tags: initiation-rates, nsduh-2011, prevalence-estimates, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Compound 528503: 5-Ethyloctadecane

Chemical compound data from PubChem database. IUPAC Name: 5-ethyloctadecane. Molecular Formula: C20H42. Molecular Weight: 282.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
St. Louis, MO-IL

This report presents combined 2005 to 2010 National Survey on Drug Use and Health (NSDUH) results for those aged 12 or older in the St. Louis, MO-IL metro area. The report includes estimates of substance use disorder, major depressive episode, illicit drug use, marijuana use, cigarette use, binge alcohol use, and the nonmedical use of prescription-type pain relievers. Results are provided for the St. Louis metro area, Missouri, and the U.S. overall.

Tags: major-depression, nsduh-data, samhsa, st-louis-metro, substance-use
Organization: U.S. Department of Health & Human Services
The Maltreatment of Children with Disabilities and Child Maltreatment in Substance Abusing Families, 1991

This study examines the incidence of substantiated maltreatment among children with cognitive, physical, emotional or learning disabilities, with specific attention given to the relationship between maltreatment and disabilities. It also investigates the incidence of child abuse and neglect among children in substance abusing families, and the relationship between child abuse and familial substance abuse.  The data were collected from a nationally representative group of 35 Child Protective Services (CPS) agencies, which were asked to provide information on all cases of substantiated maltreatment over a four to six week period in early 1991. The Archive distributes 5 data files for this study which provide information on a total of 1,249 substantiated maltreatment incidents.  A case-level data file includes demographic information on the children and adults involved in each case, information on the timing, type, and reporting of maltreatment, data on the relationships between the individuals involved in each case, and case status.  A second file contains caseworker assessments of  children with suspected or known disabilities, as well as information on the sources and reliability of those assessments.  An estimated 14.1 percent of the children in the study were identified by caseworkers as having one or more disabilities, using the definition found in the Americans with Disabilities Act (P.L. 101-336).  A third data file contains substance abuse information for each adult in the study suspected of substance abuse.  In addition to the three files mentioned above there are two files the which the Archive distributes which are restructured versions of the case-level file, in which the unit of analysis has been changed to represent an individual involved in a case.

Investigators: Ratnofsky, A., & Crosse, S.

Tags: abuse, care, ndacan, policy, reporting
Organization: U.S. Department of Health & Human Services
Table 4. Perceptions of Great Risk of Smoking Marijuana Once a Month, by Age Group and State: Percentages, Annual Averages Based on 2010 and 2011 NSDUHs

This report presents State estimates for measures of perceptions of great risk of smoking marijuana once a month based on the combined 2010 and 2011 National Surveys on Drug Use and Health (NSDUHs). Results are provided for youth aged 12 to 17.

Tags: marijuana-risk-perception, nsduh-data, samhsa, substance-abuse, youth-drug-use
Organization: U.S. Department of Health & Human Services
North Dakota: 2011-2012 NSDUH

This report presents North Dakota\'s estimates for 25 measures of substance use and mental health based on the combined 2011 and 2012 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided by State and for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: mental-health, north-dakota, nsduh, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Compound 525338: 2,6-Dimethylthioanisole

Chemical compound data from PubChem database. IUPAC Name: 1,3-dimethyl-2-methylsulfanylbenzene. Molecular Formula: C9H12S. Molecular Weight: 152.26. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services