AndreaBozzo/ceres-open-data-index huggingface dataset:
Publications Using SAMHSA Data2010 CMHS Uniform Reporting System (URS) Output Tables for Idaho

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2010. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, national-outcome-measures, samhsa, urs-data
Organization: U.S. Department of Health & Human Services
AFCARS Technical Bulletin #9 - Data File Format

This TB supplements information in 45 CFR 1355.40, and the Appendices to Part 1355 by providing additional guidance on the AFCARS file format and the proper naming convention to be used for AFCARS files.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: data, instruction, policy, reporting, standard
Organization: U.S. Department of Health & Human Services
Common Pitfalls and How to Avoid Them

Through the webinar series, “Back to Basics”, the Division of State Systems within the Children’s Bureau, is offering a venue for information sharing and discussion. The fourth webinar of the series, “Common Pitfalls and How to Avoid Them”, reviews nine common pitfalls associated with building and maintaining child welfare information systems including: lack of user involvement; poorly defined requirements; scope creep, lack of a change control system, poor testing, under-allocated resources, system performance issues, lack of a high-functioning user help desk and poor vendor relationship.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: child, guidance, policy, scope, system
Organization: U.S. Department of Health & Human Services
Primary effect of chemotherapy on the transcription profile of AIDS-related Kaposi's sarcoma

Background
          Drugs & used in anticancer chemotherapy have severe effects upon the cellular transcription and replication machinery. From in vitro studies it has become clear that these drugs can affect specific genes, as well as have an effect upon the total transcriptome.
        
        
          Methods
          Total mRNA from two skin lesions from a single AIDS-KS patient was analyzed with the SAGE (Serial Analysis of Gene Expression) technique to assess changes in the transcriptome induced by chemotherapy. SAGE libraries were constructed from material obtained 24 (KS-24) and 48 (KS-48) hrs after combination therapy with bleomycin, doxorubicin and vincristine. KS-24 and KS-48 were compared to SAGE libraries of untreated AIDS-KS, and to libraries generated from normal skin and from isolated CD4+ T-cells, using the programs USAGE and HTM. SAGE libraries were also compared with the SAGEmap database.
        
        
          Results
          In order to assess the primary response of AIDS-related Kaposi's sarcoma (AIDS-KS) to chemotherapy in vivo, we analyzed the transcriptome of AIDS-KS skin lesions from a HIV-1 seropositive patient at two time points after therapy. The mRNA profile was found to have changed dramatically within 24 hours after drug treatment. There was an almost complete absence of transcripts highly expressed in AIDS-KS, probably due to a transcription block. Analysis of KS-24 suggested that mRNA pool used in its construction originated from poly(A) binding protein (PABP) mRNP complexes, which are probably located in nuclear structures known as interchromatin granule clusters (IGCs). IGCs are known to fuse after transcription inhibition, probably affecting poly(A)+RNA distribution.
          Forty-eight hours after chemotherapy, mRNA isolated from the lesion was largely derived from infiltrating lymphocytes, confirming the transcriptional block in the AIDS-KS tissue.
        
        
          Conclusions
          These in vivo findings indicate that the effect of anti-cancer drugs is likely to be more global than up- or downregulation of specific genes, at least in this single patient with AIDS-KS. The SAGE results obtained 24 hrs after chemotherapy can be most plausibly explained by the isolation of a fraction of more stable poly(A)+RNA.

Tags: aids-related-cancer, chemotherapy-effects, gene-expression, kaposis-sarcoma, nih
Organization: U.S. Department of Health & Human Services
Treatment Episode Data Set (TEDS) 1995-2005 National Admissions to Substance Abuse Treatment Services

This report presents results from the Treatment Episode Data Set (TEDS) for 2005 and trend data for 1995-2005. The report provides information on the demographic and substance abuse characteristics of the 1.8 million people admitted to treatment for abuse of alcohol and drugs in 2005 to facilities that report to individual state administrative data systems.

Tags: alcohol-drug-abuse, samhsa, substance-abuse-treatment, teds, treatment-admissions
Organization: U.S. Department of Health & Human Services
Effect of a homeopathic drug, Chelidonium, in amelioration of p-DAB induced hepatocarcinogenesis in mice

Background
          Crude extracts of Chelidonium majus, and also purified compounds derived from crude extracts of this plant, have been reported to exhibit anti-viral, anti-inflammatory, anti-tumor and anti-microbial properties both in vitro and in vivo. Chelidonium is a homeopathic drug routinely used against various liver disorders including cancer in humans. Two potencies of Chelidonium (Ch-30, Ch-200) have been tested for their possible anti-tumor and enzyme modulating activities in liver and anti-clastogenic effects during p-DAB-induced hepatocarcinogenesis in mice compared to suitable controls.
        
        
          Methods
          Several cytogenetic and enzymatic protocols were used at three fixation intervals; at 60 days, 90 days and 120 days of treatment. Different sets of healthy mice were fed: i) hepatocarcinogen, p-DAB plus phenobarbital (PB), ii) only PB, iii) neither p-DAB nor PB (normal control). One set of mice fed with p-DAB plus PB was also fed Ch-30 (iv) and another set Ch-200 (v). All standard currently used methods were adopted for cytogenetical preparations and for the enzyme assays.
        
        
          Results
          All group (i) mice developed tumors in liver at all fixation intervals, while none of group (ii) and (iii) mice developed any tumors. About 40% mice in group (iv) and group (v) did not show tumor nodules in their liver. Feeding of Chelidonium to group (iv) and (v) mice reduced genotoxic effects to a significant extent (p < 0.05 to p < 0.001).
        
        
          Conclusion
          The homeopathic drug Chelidonium exhibited anti-tumor and anti-genotoxic activities and also favorably modulated activities of some marker enzymes. Microdoses of Chelidonium may be effectively used in combating liver cancer.

Tags: chelidonium, hepatocarcinogenesis, homeopathic-drug, liver-cancer, nih
Organization: U.S. Department of Health & Human Services
Compound 525576: N,N-Dimethyl-N'-(3-methoxyphenyl)-p-methylbenzamidine

Chemical compound data from PubChem database. IUPAC Name: N'-(3-methoxyphenyl)-N,N,4-trimethylbenzenecarboximidamide. Molecular Formula: C17H20N2O. Molecular Weight: 268.35. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Complicated infective endocarditis necessitating ICU admission: clinical course and prognosis

Aim
          To study incidence, clinical course and prognostic factors in patients admitted to medical intensive care units (ICUs) because of a complicated course of infective endocarditis.
        
        
          Method
          This was a retrospective multicenter observational study of 4106 patients admitted to four medical ICUs in one tertiary hospital and one university hospital between 1994 and 1999.
        
        
          Results
          Infective endocarditis was identified in 33 (0.8%) patients. Of these, 26 were male, mean age was 59 ± 12 and APACHE-III score was 75 ± 31. Reasons for transfer to the ICU were congestive heart failure in 64%, septic shock in 21%, neurological deterioration in 15% and cardiopulmonary resuscitation in 9%. Inotropes or vasoconstrictors were required in 73% and multiorgan failure developed in 64% of the patients. Prosthetic valve endocarditis was present in 21%. Gram-positive cocci were found in 96% of all positive cultures; cultures were negative in 27% of the patients. Transthoracic echocardiograms were diagnostic in only 33% and transesophageal studies were required in 91% to confirm diagnosis or fully to delineate the extent of disease. Surgical intervention was performed in 60% of the patients, and the remaining 40% were only treated medically. The APACHE-III score on admission did not differ statistically between the two groups (69 ± 30 versus 84 ± 34, P = 0.17). In-patient mortality was 84% in patients treated medically, and 35% in surgically treated patients. Using multivariate analysis, acute renal failure on admission was identified as the independent single predictor for in-patient death (OR 5, 95% CI 1.04–24.03, P = 0.04).
        
        
          Conclusion
          The prognosis for patients with infective endocarditis requiring admission to a medical ICU is serious. Nevertheless, the data suggest that surgical intervention may be successfully performed in a substantial number of patients despite the presence of severe shock and occurrence of multiorgan failure.

Tags: icu-admission, infective-endocarditis, nih, prognostic-factors, septic-shock
Organization: U.S. Department of Health & Human Services
Selected highlights from the 50

The recent scientific session of the American College of Cardiology (ACC), held in Orlando, provided a forum for ongoing cardiovascular clinical trials from around the world. The high point was clearly the first ever release of results from the CURE study. The Late-Breaking Clinical Trials sessions also featured results and interim data from other trials such as MIRACLE, CAPRICORN, SVG WRIST, RITZ 2, SoS and PRINCE. New applications for data from the OPUS-TIMI16 trial were discussed and promising results from initial studies into the experimental drug ALT-711 showed the way for further studies.

Tags: acute-coronary-syndrome, cardiology-research, cardiovascular-disease, clinical-trials, nih
Organization: U.S. Department of Health & Human Services
Physiology in medicine: importance of hypoxic pulmonary vasoconstriction in maintaining arterial oxygenation during acute respiratory failure

Hypoxic pulmonary vasoconstriction continues to attract interest more than half a century after its original report because of persistent mystery about its biochemical mechanism and its exact physiological function. Recent work suggests an important role for pulmonary arteriolar smooth muscle cell oxygen-sensitive voltage-dependent potassium channels. Inhibition of these channels by decreased PO2 inhibits outward potassium current, causing membrane depolarization, and calcium entry through voltage-dependent calcium channels. Endothelium-derived vasoconstricting and vasodilating mediators modulate this intrinsic smooth muscle cell reactivity to hypoxia. However, refined modeling of hypoxic pulmonary vasoconstriction operating as a feedback mechanism in inhomogeneous lungs, using more realistic stimulus-response curves and confronted with direct measurements of regional blood flow distribution, shows a more effective than previously assessed ability of this remarkable intrapulmonary reflex to improve gas exchange and arterial oxygenation. Further studies could show clinical benefit of pharmacological manipulation of hypoxic pulmonary vasoconstriction, in circumstances of life-threatening hypoxemia.

Tags: acute-respiratory-failure, arterial-oxygenation, hypoxic-vasoconstriction, nih, pulmonary-physiology
Organization: U.S. Department of Health & Human Services
Drug Abuse Warning Network (DAWN): National Estimates of Polysubstance Involved Emergency Department Visits

This report presents data from DAWN to describe national estimates of polysubstance-involved emergency department (ED) visits in the United States in 2024. It provides estimates of polysubstance-involved ED visits by (1) patient characteristics, (2) psychoactive drug involved, and (3) co-occurrence (or combination) of psychoactive drugs.

Tags: drug-overdose, emergency-department-visits, polysubstance-abuse, samhsa, substance-use-trends
Organization: U.S. Department of Health & Human Services
Compound 527368: 18,22-Dimethyl-triacontyl cyanide

Chemical compound data from PubChem database. IUPAC Name: 19,23-dimethylhentriacontanenitrile. Molecular Formula: C33H65N. Molecular Weight: 475.9. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Child and Family Services Reviews Update

The Child and Family Services Reviews Update is a newsletter distributed periodically by e-mail and designed for professionals interested in the Federal Child and Family Services Reviews. It is supported by the Children's Bureau, Administration for Children and Families, U.S. Department of Health and Human Services and published by the Child Welfare Reviews Project.

For more information about the Update or to subscribe, contact the Child Welfare Reviews Project. Links to previously distributed issues of the Child and Family Services Reviews Update are provided below:

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: assessment, child, family, policy, scope
Organization: U.S. Department of Health & Human Services
Compound 525464: Propane, 2,2-bis(ethylthio)-

Chemical compound data from PubChem database. IUPAC Name: 2,2-bis(ethylsulfanyl)propane. Molecular Formula: C7H16S2. Molecular Weight: 164.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Availability of Payment Assistance for Mental Health Services in U.S. Mental Health Treatment Facilities

A substantial proportion of adults and adolescents experience mild to severe mental health symptoms in the past year, but a large proportion of those individuals do not receive treatment.  One of the main reasons they say they do not receive treatment is because the services are too expensive.  This short report uses data from the 2010 National Mental Health Services Survey (N-MHSS) to examine the numbers of mental health treatment facilities that offer payment assistance.  The report finds that most mental health treatment facilities offered some form of payment assistance, either by using a sliding-fee scale or by offering services at no charge to those who cannot afford to pay. These findings are discussed in light of health care reform that may increase the affordability of mental health treatment services.

Tags: cost-of-care, mental-health-services, payment-assistance, samhsa, treatment-facilities
Organization: U.S. Department of Health & Human Services
2023 Uniform Reporting System (URS) Table For Nevada

This is the 2023 Uniform Reporting System (URS) Output Tables for Nevada. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-data, mental-health-services, nevada-urs, noms-measures, samhsa
Organization: U.S. Department of Health & Human Services
2019 Uniform Reporting System (URS) Table for Northern Mariana Islands

These are the 2019 Uniform Reporting System (URS) Output Tables for Northern Mariana Islands. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-data, mental-health-services, noms-measures, northern-mariana-islands, samhsa
Organization: U.S. Department of Health & Human Services
Connecticut: 2011-2012 NSDUH

This report presents Connecticut\'s estimates for 25 measures of substance use and mental health based on the combined 2011 and 2012 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided by State and for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: connecticut, mental-health, nsduh, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
2017 Uniform Reporting System (URS) Table for Minnesota

This is the 2017 Uniform Reporting System (URS) Output Tables for Minnesota. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-data, mental-health-services, minnesota-mental-health, outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Compound 525096: 1,3-Dichloroisopropyl heptanoate

Chemical compound data from PubChem database. IUPAC Name: 1,2-dichloropropan-2-yl heptanoate. Molecular Formula: C10H18Cl2O2. Molecular Weight: 241.15. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Effects of de-industrialization on unemployment, re-employment, and work conditions in a manufacturing workforce

Background
          The purpose of this study was to investigate the impact of a 20-year process of de-industrialization in the British Columbia (BC) sawmill industry on labour force trajectories, unemployment history, and physical and psychosocial work conditions as these are important determinants of health in workforces.
        
        
          Methods
          The study is based on a sample of 1,885 respondents all of whom were sawmill workers in 1979, a year prior to commencement of de-industrialization and who were followed up and interviewed approximately 20 years later.
        
        
          Results
          Forty percent of workers, 64 years and under, were employed outside the sawmill sector at time of interview. Approximately one third of workers, aged 64 and under, experienced 25 months of more of unemployment during the study period. Only, 1.5% of workers were identified as a "hard core" group of long-term unemployed. Workers re-employed outside the sawmill sector experienced improved physical and psychosocial work conditions relative to those employed in sawmills during the study period. This benefit was greatest for workers originally in unskilled and semi-skilled jobs in sawmills.
        
        
          Conclusions
          This study shows that future health studies should pay particular attention to long-term employees in manufacturing who may have gone through de-industrialization resulting in exposures to a combination of sustained job insecurity, cyclical unemployment, and adverse physical and psychosocial work conditions.

Tags: de-industrialization, labor-force, nih, sawmill-workers, unemployment-history
Organization: U.S. Department of Health & Human Services
Splinting or surgery for carpal tunnel syndrome? Design of a randomized controlled trial [ISRCTN18853827]

Background
          Carpal tunnel syndrome is a common disorder, which can be treated with surgery or conservative options. However, there is insufficient evidence and no consensus among physicians with regard to the preferred treatment for carpal tunnel syndrome. Therefore, a randomized controlled trial is conducted to compare the short- and long-term efficacy of surgery and splinting in patients with carpal tunnel syndrome. An attempt is also made to avoid the (methodological) limitations encountered in earlier trials on the efficacy of various treatment options for carpal tunnel syndrome.
        
        
          Methods
          Patients of 18 years and older, with clinically and electrophysiologically confirmed idiopathic carpal tunnel syndrome, are recruited by neurologists in 13 hospitals. Patients included in the study are randomly allocated to either open carpal tunnel release or wrist splinting during the night for at least 6 weeks. The primary outcomes are general improvement, waking up at night and severity of symptoms (main complaint, night and daytime pain, paraesthesia and hypoesthesia). Outcomes are assessed up to 18 months after randomization.

Tags: carpal-tunnel-release, carpal-tunnel-syndrome, nih, randomized-controlled-trial, wrist-splinting
Organization: U.S. Department of Health & Human Services
2012-2014 NSDUH Substate Region Shapefile

This report provides a guide to the development and presentation of 2012-2014 NSDUH substate estimates. A summary of the estimation methodology is included as well as sample sizes, response rates, and population estimates.This shapefile includes geographic boundaries of the 2012-2014 NSDUH substate regions along with prevalence rates, map group values, and the upper and lower bounds found in the map legends. It can be used for analysis and data display with Geographic Information Systems (GIS) software.

Tags: gis-shapefile, mental-health, prevalence-rates, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
2015 NSDUH Instrument Protocol Changes

The 2015 National Survey on Drug Use and Health (NSDUH) instrumentation protocols underwent several modifications from the protocols employed for the 2014 NSDUH. A summary of the changes for the 2015 NSDUH can be divided into three topics: (1) the computer-assisted interviewing (CAI) tablet screening instrument, (2) the CAI questionnaire, and (3) the interviewer materials.

Tags: instrument-changes, mental-health, samhsa, substance-use, survey-methods
Organization: U.S. Department of Health & Human Services