AndreaBozzo/ceres-open-data-index huggingface dataset:
Technical Bulletin #23 — Compliance and Penalties

This technical bulletin provides title IV-E agencies with information on the standards an AFCARS data file must meet to comply with the provisions of the AFCARS regulations found at 45 CFR §1355.41— §1355.47. This technical bulletin was last revised on June 10, 2024.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: compliance, guidance, policy, reporting, standard
Organization: U.S. Department of Health & Human Services
Compound 528477: 4,6-Dimethyldecane

Chemical compound data from PubChem database. IUPAC Name: 4,6-dimethyldecane. Molecular Formula: C12H26. Molecular Weight: 170.33. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 525322: 5-Methyl-2H-pyrazole-3-carboxylic acid, 2-isopropenyl hydrazide

Chemical compound data from PubChem database. IUPAC Name: 5-methyl-N-(propan-2-ylideneamino)-1H-pyrazole-3-carboxamide. Molecular Formula: C8H12N4O. Molecular Weight: 180.21. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Nevada (NV)

This report presents Nevada\'s estimates for 25 measures of substance use and mental health based on the combined 2009 and 2010 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for Nevada for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: mental-health, nevada-health, nsduh-data, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Suicide Thoughts and Behavior among Adults:  Results from the 2014 National Survey on Drug Use and Health

This report is the second report under the 2014 NSDUH National First Release Reports. This report presents findings from the 2014 NSDUH on the percentages and numbers of adults aged 18 years old or older in the United States who had serious thoughts of suicide, made a suicide plan, and attempted suicide in the past 12 months. Findings for 2014 are presented for all adults aged 18 or older, young adults aged 18 to 25, adults aged 26 to 49, adults aged 50 or older, and adult males or females aged 18 or older. Trend data for suicidal thoughts and behavior also are presented by comparing estimates in 2014 with estimates in 2008 to 2013. Statistically significant differences are noted among subgroups of adults in 2014 and for differences between estimates in 2014 and those in prior years.

Tags: adult-mental-health, nsduh-survey, samhsa, suicidal-ideation, suicide-attempts
Organization: U.S. Department of Health & Human Services
2012 Uniform Reporting System (URS) Tables for Kansas

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2012. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, kansas, mental-health-services, outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Sample Size and Population Estimates Tables (Prevalence Estimates) - 8.1 to 8.13

These detailed tables show sample sizes and population estimates from the 2010 National Survey on Drug Use and Health (NSDUH). Samples sizes and population estimates are provided by age group, gender, race/ethnicity, education level, employment status, geographic area, pregnancy status, college enrollment status, and probation/parole status.

Tags: nsduh-2010, population-estimates, prevalence-estimates, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Hypoxic pulmonary vasoconstriction: role of voltage-gated potassium channels

Activity of voltage-gated potassium (Kv) channels controls membrane potential, which subsequently regulates cytoplasmic free calcium concentration ([Ca2+]cyt) in pulmonary artery smooth muscle cells (PASMCs). Acute hypoxia inhibits Kv channel function in PASMCs, inducing membrane depolarization and a rise in [Ca2+ ]cyt that triggers vasoconstriction. Prolonged hypoxia inhibits expression of Kv channels and reduces Kv channel currents in PASMCs. The consequent membrane depolarization raises [Ca2+]cyt, thus stimulating PASMC proliferation. The present review discusses recent evidence for the involvement of Kv channels in initiation of hypoxic pulmonary vasoconstriction and in chronic hypoxia-induced pulmonary hypertension.

Tags: hypoxic-vasoconstriction, nih, potassium-channels, pulmonary-hypertension, smooth-muscle-cells
Organization: U.S. Department of Health & Human Services
Clinical review: Intensive care follow-up – what has it told us?

The majority of intensive care practitioners, until comparatively recently, was content to discharge surviving patients to the care of referring primary specialty colleagues who would undertake subsequent inpatient and outpatient care. With the exception of mortality statistics from clinical studies, the practitioners were thus denied the opportunity of understanding the full impact of critical illness on a patient and their family. The concept of the intensive care follow-up clinic has developed more recently, and is run commonly on multidisciplinary lines. These clinics serve a number of purposes, but importantly have drawn attention to broader patient-centred outcomes after intensive care. Investigators are just beginning to identify, and in some cases quantify, the postdischarge burden on patient and family; additional useful data have also come from follow-up of specific disease states. The purpose of the present review is to highlight some of the important issues that impact on recovery from critical illness towards an acceptable quality of postdischarge life. We have concentrated on the adult literature, and specifically on studies that inform us about the more general effects of critical illness. Head and spinal injury are thus largely ignored, as the effects of the primary injury overwhelm the effects of 'general' critical illness.

Tags: critical-illness-outcomes, icu-follow-up, nih, post-intensive-care, quality-of-life
Organization: U.S. Department of Health & Human Services
CFSR Technical Bulletin #8

This Technical Bulletin provides detail on how CB calculates whether a state has met the national standards that will be used in CFSR Round 3.

Excel Workbooks of State CFSR Performance as of 10/10/2014 are available in the CFSR Round 3 Statewide Data Indicators - Workbook listed under Data Indicators and National Standards on the CFSR Information Portal Round 3 Resources page
  
  

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Metadata-only record linking to the original dataset. Open original dataset below.

Tags: assessment, child, compliance, policy, standard
Organization: U.S. Department of Health & Human Services
RNA triphosphatase is essential in

Background
          The first two steps in the capping of cellular mRNAs are catalyzed by the enzymes RNA triphosphatase and RNA guanylyltransferase. Although structural and mechanistic differences between fungal and mammalian RNA triphosphatases recommend this enzyme as a potential antifungal target, it has not been determined if RNA triphosphatase is essential for the growth of fungal species that cause human disease.
        
        
          Results
          We show by classical genetic methods that the triphosphatase (Pct1) and guanylyltransferase (Pce1) components of the capping apparatus in the fission yeast Schizosaccharomyces pombe are essential for growth. We were unable to disrupt both alleles of the Candida albicans RNA triphosphatase gene CaCET1, implying that the RNA triphosphatase enzyme is also essential for growth of C. albicans, a human fungal pathogen.
        
        
          Conclusions
          Our results provide the first genetic evidence that cap synthesis is essential for growth of an organism other than Saccharomyces cerevisiae and they validate RNA triphosphatase as a target for antifungal drug discovery.

Tags: antifungal-target, candida-albicans, gene-essentiality, nih, rna-triphosphatase
Organization: U.S. Department of Health & Human Services
New York City – 5 Boros: Drug-Related Emergency Department Visits, 2004-2011 - Seeking Detox

Excel file with estimates, rates, relative standard errors, trends and confidence intervals for all drug-related emergency department (ED) visits involving patients seeking detox in New York City (5 boroughs), covering 2004-2011. This includes nonemergency requests made through the ED for admission to detoxification unit, visits to obtain medical clearance before being incarcerated, and acute emergencies where an individual is experiencing withdrawal symptoms and requests detox. These estimates do not include patients who seek or enter the hospital\'s detox unit through other avenues.

Tags: detoxification-seeking, drug-related-ed-visits, nyc-boroughs, samhsa, substance-use-trends
Organization: U.S. Department of Health & Human Services
Th2 cytokines and asthma — The role of interleukin-5 in allergic eosinophilic disease

Interleukin-5 is produced by a number of cell types, and is responsible for the maturation and release of eosinophils in the bone marrow. In humans, interleukin-5 is a very selective cytokine as a result of the restricted expression of the interleukin-5 receptor on eosinophils and basophils. Eosinophils are a prominent feature in the pulmonary inflammation that is associated with allergic airway diseases, suggesting that inhibition of interleukin-5 is a viable treatment. The present review addresses the data that relate interleukin-5 to pulmonary inflammation and function in animal models, and the use of neutralizing anti-interleukin-5 monoclonal antibodies for the treatment of asthma in humans.

Tags: asthma-treatment, eosinophilic-disease, interleukin-5, nih, pulmonary-inflammation
Organization: U.S. Department of Health & Human Services
2011 State Profile — West Virginia

This is a National Survey of Substance Abuse Treatment Services (N-SSATS) data table showing state profile for West Virginia in 2011. N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 States, the District of Columbia, and other U.S. jurisdictions.

Tags: n-ssats, samhsa, substance-abuse-treatment, treatment-facilities, west-virginia
Organization: U.S. Department of Health & Human Services
National Survey of Substance Abuse Treatment Services (N-SSATS): 2019, Data on Substance Abuse Treatment Facilities

This report presents results from the 2019 National Survey of Substance Abuse Treatment Services (N-SSATS), an annual census of facilities providing substance abuse treatment. Conducted by the Substance Abuse and Mental Health Services Administration (SAMHSA), N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 states, the District of Columbia, and other jurisdictions. It is important to note that values in charts, narrative lists, and percentage distributions are calculated using actual raw numbers and rounded for presentation in this report; calculations using rounded values may produce different results.

Tags: addiction-services, n-ssats, samhsa, substance-abuse-treatment, treatment-facility-census
Organization: U.S. Department of Health & Human Services
Compound 525434: 3,5,6-Trimethyl-4-thiaheptane

Chemical compound data from PubChem database. IUPAC Name: 2-butan-2-ylsulfanyl-3-methylbutane. Molecular Formula: C9H20S. Molecular Weight: 160.32. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Indian Child Welfare Act; Receipt of Designated Tribal Agents for Service of Notice Bureau of Indian Affairs

Indian Child Welfare Act; Receipt of Designated Tribal Agents for Service of Notice Bureau of Indian Affairs
  
  

 (PDF) - This Federal Register notice lists the designated tribal agents for service of notice proceedings under the Indian Child Welfare Act, 25 CFR 23.12.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: affair, child, data, legal, policy
Organization: U.S. Department of Health & Human Services
Preventing infection from reusable medical equipment: a systematic review

Background
          In 2000, the World Health Organization (WHO) had eight sets of conflicting recommendations for decontaminating medical equipment. We conducted a systematic review of observational studies to assist WHO in reconciling the various guidelines. This paper summarises the methods developed and illustrates the results for three procedures – alcohol, bleach and povidone iodine.
        
        
          Methods
          We developed a Medline search strategy and applied inclusion criteria specifying the decontamination procedures of interest and an outcome of microbial destruction for a set of marker organisms. We developed protocols to assess the quality of studies and categorised them according to the reliability of the methods used. Through an iterative process we identified best practice for the decontamination methods and key additional factors required to ensure their effectiveness. We identified 88 published papers for inclusion, describing 135 separate studies of decontamination.
        
        
          Results
          For disinfection with alcohol, best practice was identified from 23 studies as an exposure to 70–80% ethanol or isopropanol for at least 5 minutes. Bleach was effective for sterilization at a concentration of 5000 ppm for 5 minutes and for disinfection at 1000 ppm for 10 minutes (33 studies). Povidone iodine was only partially effective for disinfection at a concentration of 1% for 15 minutes (15 studies).
        
        
          Conclusions
          Our findings provide an evidence base for WHO guidelines on decontaminating medical equipment. The results support the recommended use of bleach and show that alcohol could be used more widely than current guidelines suggest, provided best practice is followed. The effectiveness of povidone iodine is uncertain.

Tags: disinfection-methods, infection-prevention, medical-equipment-decontamination, nih, systematic-review
Organization: U.S. Department of Health & Human Services
Strengthening Abuse and Neglect Courts Act of 2000

Strengthening Abuse and Neglect Courts Act of 2000
  
  

 (PDF) - This document provides the text of the Strengthening Abuse and Neglect Courts Act of 2000.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: abuse, child, legal, neglect, policy
Organization: U.S. Department of Health & Human Services
Compound 525318: 1-Heptadecanol, butanoate

Chemical compound data from PubChem database. IUPAC Name: heptadecyl butanoate. Molecular Formula: C21H42O2. Molecular Weight: 326.6. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2018 Uniform Reporting System (URS) Table for Mississippi

This is the 2018 Uniform Reporting System (URS) Output Tables for Mississippi. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: mental-health-services, mississippi, national-outcome-measures, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
Immune ablation and stem-cell therapy in autoimmune disease: Immunological reconstitution after high-dose immunosuppression and haematopoietic stem-cell transplantation

Studies on immunological reconstitution after immune ablation and stem-cell therapy may yield important clues to our understanding of the pathogenesis of human autoimmune disease, due to the profound effects of function and organization of the immune system. Such studies are also indispensable when linking clinical sequelae such as opportunistic infections to the state of immune deficiency that ensues after the treatment. Much has been learnt on these issues from comparable studies in haemato-oncological diseases, although it remains to be proven that the data obtained from these studies can be extrapolated to rheumatological autoimmune diseases. Preliminary results from pilot studies in various rheumatological conditions not only pointed to clinical efficacy of the new treatment modality but also unveiled marked effects on T-cell receptor repertoires of circulating T lymphocytes, on titres of autoantibodies and T- and B-cell subsets.

Tags: autoimmune-diseases, immune-ablation, immune-reconstitution, nih, stem-cell-therapy
Organization: U.S. Department of Health & Human Services
Compound 525399: 2,8-Dimethyl-4,6-dithianonane

Chemical compound data from PubChem database. IUPAC Name: 2-methyl-1-(2-methylpropylsulfanylmethylsulfanyl)propane. Molecular Formula: C9H20S2. Molecular Weight: 192.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 525520: 3-(4-Cyclohexyl-methyl-oxy-phenyl)-propionic acid, methyl ester

Chemical compound data from PubChem database. IUPAC Name: methyl 3-[4-(cyclohexylmethoxy)phenyl]propanoate. Molecular Formula: C17H24O3. Molecular Weight: 276.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Indiana, 2013

This is a behavioral health report for the state of Indiana. It uses the  National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment Services (NSSATS) to address the topics of youth substance use , youth mental health and treatment, adult mental health and treatment, substance use, substance use treatment  for the years 2008 to 2012.

Tags: behavioral-health, indiana, mental-health, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Debate: What constitutes 'terminality' and how does it relate to a Living Will?

A moribund and debilitated patient arrives in an emergency department and is placed on life support systems. Subsequently it is determined that she has a 'living will' proscribing aggressive measures should her condition be judged 'terminal' by her physicians. But, as our round table of authorities reveal, the concept of 'terminal' means different things to different people. The patient's surrogates are unable to agree on whether she would desire continuation of mechanical ventilation if there was a real chance of improvement or if she would want to have her living will enforced as soon it's terms were revealed. The problem of the potential ambiguity of a living will is explored.

Tags: end-of-life-care, living-wills, medical-ethics, nih, terminal-illness
Organization: U.S. Department of Health & Human Services
Table 7. Cocaine Use in the Past Year among Persons Aged 12 or Older, by State and Substate Regions: Percentages, Annual Averages Based on 2008, 2009, and 2010 NSDUHs

This table presents the 2008 to 2010 National Survey on Drug Use and Health (NSDUH) estimates of past year cocaine use by those aged 12 or older by State and substate regions.

Tags: adolescent-drug-use, cocaine-use, nsduh-data, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
NSDUH 2020 Pill Images for the NSDUH Questionnaire

This report contains the pill images used in the ACASI portion of the NSDUH questionnaire.  These images are copyrighted and may not be reproduced.  The owner of the copyright is SFI Medical Publishing of Lawrence, Kansas.

Tags: medication-images, nsduh-questionnaire, pill-identification, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
New York 2016 Potential Areas for Addressing Service Gaps for Opioid Treatment

The purpose of the medication-assisted treatment (MAT) facility maps is to identify areas on a state-by-state basis that may be potentially underserved by existing treatment facilities. The maps are created with a methodology that seeks to include the highest potential need areas from individual counties so that county-level stakeholders are also informed. The maps are meant to be used as a tool for policy makers to determine potentially underserved areas—not as a definitive representation of these areas.

Tags: mat-access, new-york-state, opioid-treatment, samhsa, service-gap-analysis
Organization: U.S. Department of Health & Human Services
Diagnostic criteria for diabetes revisited: making use of combined criteria

Background
          Existing cut-offs for fasting plasma glucose (FPG) and post-load glucose (2hPG) criteria are not equivalent in the diagnosis of diabetes and glucose intolerance. Adjusting cut-offs of single measurements have not helped so we undertook this project to see if they could be complementary.
        
        
          Methods
          We performed oral glucose tolerance tests and mean levels of hemoglobin A1c (HbA1c) measurements on 43 patients referred to a diabetes clinic for possible diabetes. Results of single and combined use of the FPG and 2hPG criteria were evaluated against the levels of HbA1c and results re-interpreted in the light of existing reports in the literature.
        
        
          Results
          Our results confirm that the FPG and the 2hPG, being specific and sensitive respectively for the presence of glucose intolerance or diabetes, are not equivalent. They are shown to be indeed complementary and a re-definition of diagnostic criteria based on their combined use is proposed.
        
        
          Conclusions
          We conclude that altering single measurement cut-offs for the diagnosis of diabetes and altered glucose tolerance will not result in better outcomes. We present the case for a combined criteria in the diagnosis and definition of diabetes with a FPG≥7 mmol/L AND 2-hour glucose ≥7.8 mmol/L being used to define diabetes while a FPG<7 mmol/L AND 2-hour glucose <7.8 mmol/L being used to define normality. Discordant values will define impaired glucose tolerance (IGT). This proposal requires prospective evaluation in a large cohort.

Tags: diabetes-diagnosis, diagnostic-criteria, glucose-tolerance-test, hba1c-levels, nih
Organization: U.S. Department of Health & Human Services