AndreaBozzo/ceres-open-data-index huggingface dataset:
A geometric and algebraic view of MHC-peptide complexes and their binding properties

Background
          Major histocompatibility complex (MHC) molecules present peptides to T lymphocytes. It is of critical biological and medical importance to elucidate how different MHC alleles bind to a specific set of peptides.
        
        
          Method
          In this study we approach the problem from the algebraic and geometric point of view to analyse MHC-peptide-binding data accumulated over the years. The space of sequence properties (having a particular amino acid at a particular position) of MHC-peptide complexes conveys a geometric structure to these sequence properties in the form of a distance measure, which reveals the peptide binding requirements imposed by the polymorphic sequence characteristics of the MHC molecules.
        
        
          Results
          Comparison of the results of this study with our current knowledge of MHC-peptide binding constraints leads to robust agreement. This study provides the tools to quantitate these binding constraints giving a more detailed account of them and opening the way to make peptide binding predictions for MHC alleles for which there is no peptide elution data. In addition, the geometric representation of MHC-peptide complex sequence data gives a distance measure between amino acids in reference to their ability to meet MHC binding requirements.
        
        
          Conclusions
          The algebraic and geometric view of amino acid sequences provides a theoretical framework to study the function of proteins when there is enough variation in this sequence to account for the variation in their function, as it is the case with MHC molecules in regard to their ability to present peptides.

Tags: amino-acid-sequence, geometric-analysis, mhc-peptide-binding, nih, t-lymphocytes
Organization: U.S. Department of Health & Human Services
Boston

Data tables consisting of Excel files with estimates, rates, relative standard errors, trends and confidence intervals, covering 2004-2011, for drug-related emergency department visits for the Boston Metropolitan Statistical Area. Tables are provided for 10 topics (\"analytic categories\") which are defined in the \"Guide to Drug Abuse Warning Trend Tables,\"  a separate document.   Each table includes data for over 500 drugs, including illicit drugs, prescription and over-the-counter medications, dietary supplements, inhalants and alcohol. Includes total visits, gender, age group, race/ethnicity, outcome of visit, drug combinations, number of drugs involved in visit, drug frequency, and drugs confirmed by toxicology. Additional detail is provided for illicit drugs, psychotherapeutic drugs, central nervous system (CNS) drugs, respiratory drugs and cardiovascular drugs.

Tags: boston-msa, dawnt-data, drug-related-ed-visits, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
Peroxynitrite decomposition catalyst prevents apoptotic cell death in a human astrocytoma cell line incubated with supernatants of HIV-infected macrophages

Background
          Oxidative stress has shown to contribute in the mechanisms underlying apoptotic cell death occuring in AIDS-dementia complex. Here we investigated the role of peroxynitrite in apoptosis occurring in astroglial cells incubated with supernatants of HIV-infected human primary macrophages (M/M).
        
        
          Results
          Flow cytometric analysis (FACS) of human cultured astrocytes shortly incubated with HIV-1-infected M/M supernatants showed apoptotic cell death, an effect accompanied by pronounced staining for nitrotyrosine (footprint of peroxynitrite) and by abnormal formation of malondialdehyde (MDA). Pretreatment of astrocytes with the peroxynitrite decomposition catalyst FeTMPS antagonized HIV-related astrocytic apoptosis, MDA formation and nitrotyrosine staining.
        
        
          Conclusions
          Taken together, our results suggest that inibition of peroxynitrite leads to protection against peroxidative stress accompanying HIV-related apoptosis of astrocytes. Overall results support the role of peroxynitrite in HIV-related programmed death of astrocytes and suggest the use of peroxynitrite decomposition catalyst to counteract HIV-1-related neurological disorders.

Tags: astrocyte-apoptosis, hiv-associated-neurocognitive-disorder, nih, oxidative-stress, peroxynitrite
Organization: U.S. Department of Health & Human Services
The cost-effectiveness of the WINGS intervention: a program to prevent HIV and sexually transmitted diseases among high-risk urban women

Background
          We evaluated the cost-effectiveness of the WINGS project, an intervention to prevent HIV and other sexually transmitted diseases among urban women at high risk for sexual acquisition of HIV.
        
        
          Methods
          We used standard methods of cost-effectiveness analysis. We conducted a retrospective analysis of the intervention's cost and we used a simplified model of HIV transmission to estimate the number of HIV infections averted by the intervention. We calculated cost-effectiveness ratios for the complete intervention and for the condom use skills component of the intervention.
        
        
          Results
          Under base case assumptions, the intervention prevented an estimated 0.2195 new cases of HIV at a cost of $215,690 per case of HIV averted. When indirect costs of HIV were excluded from the analysis, the intervention's cost-effectiveness ratios were $357,690 per case of HIV averted and $31,851 per quality-adjusted life year (QALY) saved. Under base case assumptions, the condom use skills component of the intervention prevented an estimated 0.1756 HIV infections and was cost-saving. When indirect HIV costs were excluded, the cost-effectiveness ratios for the condom use skills component of the intervention were $97,404 per case of HIV averted and $8,674 per QALY saved.
        
        
          Conclusions
          The WINGS intervention, particularly the two sessions of the intervention which focussed on condom use skills, could be cost-effective in preventing HIV among women.

Tags: cost-effectiveness-analysis, hiv-prevention, nih, std-prevention, urban-women
Organization: U.S. Department of Health & Human Services
National Survey of Substance Abuse Treatment Services: State Profiles 2011

The 2011 National Survey of Substance Abuse Treatment Services (N-SSATS) is an annual survey of facilities providing substance abuse treatment. The N-SSATS, conducted by the Substance Abuse and Mental Health Services Administration (SAMHSA), is designed to collect data on the location, characteristics, services offered, and number of clients in treatment at alcohol and drug abuse facilities (both public and private) throughout the 50 states, the District of Columbia, and other U.S. jurisdictions.

Tags: alcohol-drug-abuse, n-ssats, samhsa, substance-abuse-treatment, treatment-facilities
Organization: U.S. Department of Health & Human Services
Primary ciliary dyskinesia: a report from ATS 2001, May 18–23, San Francisco

Primary ciliary dyskinesia (PCD) is a genetic disorder of abnormal ciliary structure and function that leads to defective mucociliary clearance, resulting in oto-sino-pulmonary disease, and infertility. The disease is currently under intense investigation by a number of research groups worldwide. At the recent American Thoracic Society meeting in San Francisco in May 2001, two sessions focused on PCD; a symposium session on May 21 with several featured expert speakers was followed by a mini-symposium on Tuesday May 22, with one featured speaker and presentation of nine abstracts covering a range of research topics. Mattias Salathe (University of Miami, USA) and Stephen Brody (Washington University, St Louis, USA) chaired the symposium session. Presentations focused on the clinical spectrum of PCD, the genetics of PCD, a proteomics approach to detail the structure of cilia, the role of cilia in the embryology of situs laterality, and airway epithelial cell biology. The mini-symposium was chaired by Peadar Noone (University of North Carolina, USA) and Malcolm King (University of Alberta, USA) and included presentations on the use of PCD as a human disease model, accurate definition of the phenotype using clinical and cell biologic markers, and molecular studies. The latter reports ranged from isolation of a protein involved in ciliary structure and function to genetic studies using linkage analysis and the candidate gene approach. Clinicians and scientists alike displayed considerable interest at both sessions, and there were several lively question–answer sessions.

Tags: ciliary-function, genetic-disorder, mucociliary-clearance, nih, primary-ciliary-dyskinesia
Organization: U.S. Department of Health & Human Services
2013 CMHS Uniform Reporting System (URS) Table for New Hampshire

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Tables for New Hampshire for 2013. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program.  State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, noms-measures, samhsa, urs-data
Organization: U.S. Department of Health & Human Services
Miami-Fort Lauderdale-Pompano Beach, FL

This report presents combined 2005 to 2010 National Survey on Drug Use and Health (NSDUH) results for those aged 12 or older in the Miami-Fort Lauderdale-Pompano Beach, FL metro area. The report includes estimates of substance use disorder, major depressive episode, illicit drug use, marijuana use, cigarette use, binge alcohol use, and the nonmedical use of prescription-type pain relievers. Results are provided for the Miami-Fort Lauderdale-Pompano Beach metro area, Florida, and the U.S. overall.

Tags: florida, major-depressive-episode, nsduh-data, samhsa, substance-use-disorder
Organization: U.S. Department of Health & Human Services
Vermont (VT)

This report uses 2008 to 2010 National Survey on Drug Use and Health (NSDUH) to assess past year alcohol use disorder and illicit drug use disorder among persons aged 12 or older for Vermont overall and for substate regions within Vermont. Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE).

Tags: mental-health-indicators, nsduh-data, samhsa, substance-use-disorder, vermont-health-data
Organization: U.S. Department of Health & Human Services
2019 National Survey on Drug Use and Health: Asians/Native Hawaiians and Other Pacific Islanders (NHOPI)

View the sub-population slides on Asians/Native Hawaiians and Other Pacific Islanders (NHOPI) based on the graphics, tables, and figures from the 2019 NSDUH Annual Report.

Tags: asian-pacific-islander, mental-health, nhopi-population, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Pro/con clinical debate: do colloids have advantages over crystalloids in paediatric sepsis?

Despite decades of resuscitating patients with intravenous fluids in intensive care units, it is somewhat surprising that very little consensus exists regarding the type of fluid physicians should choose. Factors that influence decisions are often local culture or politics, hospital administrators, history (i.e. 'I've always done it this way') and budgets, as opposed to strong evidence. In the present issue of Critical Care we are presented with compelling arguments for and against the administration of colloids (as opposed to crystalloids) in paediatric sepsis. One point that appears to be clear is that the ideal choice of intravenous fluid goes beyond the simple haemodynamic effect. As such, in the future, clinicians will need to consider other factors when making their decision. In addition, large-scale quality randomised studies are desperately needed to guide clinicians.

Tags: colloids-vs-crystalloids, fluid-resuscitation, nih, pediatric-sepsis
Organization: U.S. Department of Health & Human Services
Insertion of a small peptide of six amino acids into the β7–β8 loop of the p51 subunit of HIV-1 reverse transcriptase perturbs the heterodimer and affects its activities

Background
          HIV-1 RT is a heterodimeric enzyme, comprising of the p66 and p51 subunits. Earlier, we have shown that the β7-β8 loop of p51 is a key structural element for RT dimerization (Pandey et al., Biochemistry 40: 9505, 2001). Deletion or alanine substitution of four amino acid residues of this loop in the p51 subunit severely impaired DNA binding and catalytic activities of the enzyme. To further examine the role of this loop in HIV-1 RT, we have increased its size such that the six amino acids loop sequences are repeated in tandem and examined its impact on the dimerization process and catalytic function of the enzyme.
        
        
          Results
          The polymerase and the RNase H activities of HIV-1 RT carrying insertion in the β7-β8 loop of both the subunits (p66INS/p51INS) were severely impaired with substantial loss of DNA binding ability. These enzymatic activities were restored when the mutant p66INS subunit was dimerized with the wild type p51. Glycerol gradient sedimentation analysis revealed that the mutant p51INS subunit was unable to form stable dimer either with the wild type p66 or mutant p66INS. Furthermore, the p66INS/p66INS mutant sedimented as a monomeric species, suggesting its inability to form stable homodimer.
        
        
          Conclusion
          The data presented herein indicates that any perturbation in the β7-β8 loop of the p51 subunit of HIV-1 RT affects the dimerization process resulting in substantial loss of DNA binding ability and catalytic function of the enzyme.

Tags: enzyme-activity, hiv-1-reverse-transcriptase, molecular-biology, nih, protein-dimerization
Organization: U.S. Department of Health & Human Services
Compound 527317: Methyl 2-[3-methoxy-4-(2-methylpropyl)phenyl]propanoate

Chemical compound data from PubChem database. IUPAC Name: methyl 2-[3-methoxy-4-(2-methylpropyl)phenyl]propanoate. Molecular Formula: C15H22O3. Molecular Weight: 250.33. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2022 Uniform Reporting System (URS) Output Tables

These are the 2022 Uniform Reporting System (URS) Output Tables. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: evidence-based-practices, mental-health-services, national-outcome-measures, samhsa, state-mental-health
Organization: U.S. Department of Health & Human Services
Treatment Episode Data Set (TEDS) Highlights - 2004 National Admissions to Substance Abuse Treatment Services

This report presents summary results from the Treatment Episode Data Set (TEDS) for 2004. The report provides information on the demographic and substance abuse characteristics of the 1.9 million people admitted to treatment for abuse of alcohol and drugs that year to facilities that report to individual state administrative data systems.

Tags: alcohol-drug-abuse, samhsa, substance-abuse-treatment, teds-data, treatment-admissions
Organization: U.S. Department of Health & Human Services
Compound 525367: 2,4,4,6-Tetramethyl-3,5-dithiaheptane

Chemical compound data from PubChem database. IUPAC Name: 2,2-bis(propan-2-ylsulfanyl)propane. Molecular Formula: C9H20S2. Molecular Weight: 192.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2011-2012 NSDUH State-specific Tables

This page presents the tables of State-specific tables of State estimates for 25 measures of substance use and mental health based on the combined 2011 and 2012 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Results are provided by State and for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: mental-health, samhsa, state-level-data, substance-use, suicidal-ideation
Organization: U.S. Department of Health & Human Services
Compound 525265: N'-(2-naphthyl)-N,N-dimethyl-formamidine

Chemical compound data from PubChem database. IUPAC Name: N,N-dimethyl-N'-naphthalen-2-ylmethanimidamide. Molecular Formula: C13H14N2. Molecular Weight: 198.26. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Characterization of a protease produced by a

Background
          Several Trichoderma strains have been reported to be effective in controlling plant diseases, and the action of fungal hydrolytic enzymes has been considered as the main mechanism involved in the antagonistic process. However, although Trichoderma strains were found to impair development of Crinipellis perniciosa, the causal agent of cocoa plant witches' broom disease, no fungal strain is available for effective control of this disease. We have then undertaken a program of construction of hydrolytic enzyme-overproducing Trichoderma strains aiming improvement of the fungal antagonistic capacity. The protease of an indian Trichoderma isolate showing antagonistic activity against C. perniciosa was purified to homogeneity and characterized for its kinetic properties and action on the phytopathogen cell wall.
        
        
          Results
          A protease produced by the Trichoderma harzianum isolate 1051 was purified to homogeneity by precipitation with ammonium sulfate followed by hydrophobic chromatography. The molecular mass of this protease as determined by SDS-polyacrylamide gel electrophoresis was about 18.8 kDa. Its N-terminal amino acid sequence shares no homology with any other protease. The purified enzyme substantially affected the cell wall of the phytopathogen C. perniciosa. Western-blotting analysis showed that the enzyme was present in the culture supernatant 24 h after the Trichoderma started to grow in casein-containing liquid medium.
        
        
          Conclusions
          The capacity of the Trichoderma harzianum protease to hydrolyze the cell wall of C. perniciosa indicates that this enzyme may be actually involved in the antagonistic process between the two fungi. This fact strongly suggest that hydrolytic enzyme over-producing transgenic fungi may show superior biocontrol capacity.

Tags: biological-control, crinipellis-perniciosa, nih, protease-characterization, trichoderma-harzianum
Organization: U.S. Department of Health & Human Services
L-Glutamate production by lysozyme-sensitive

Background
          A non-pathogenic species of coryneform bacteria, Corynebacterium glutamicum, was originally isolated as an L-glutamate producing bacterium and is now used for fermentative production of various amino acids. A mutation in the C. glutamicum ltsA gene caused susceptibility to lysozyme, temperature-sensitive growth, and L-glutamate production.
        
        
          Results
          The characteristics of eight lysozyme-sensitive mutants which had been isolated after N-methyl-N'-nitro-N-nitrosoguanidine mutagenesis were examined. Complementation analysis with the cloned wild-type ltsA gene and DNA sequencing of the ItsA region revealed that four mutants had a mutation in the ltsA gene. Among them, two mutants showed temperature-sensitive growth and overproduced L-glutamate at higher temperatures, as well as the previously reported ltsA mutant. Other two showed temperature-resistant growth: one missense mutant produced L-glutamate to some extent but the other nonsense mutant did not. These two mutants remained temperature-resistant in spite of introduction of ltsA::kan mutation that causes temperature-sensitive growth in the wild-type background.
        
        
          Conclusions
          These results indicate that a defect caused by the ltsA mutations is responsible for temperature-sensitive growth and L-glutamate overproduction by C. glutamicum. The two temperature-resistant mutants seem to carry suppressor mutations that rendered cells temperature-resistance and abolished L-glutamate overproduction.

Tags: amino-acid-fermentation, corynebacterium-glutamicum, l-glutamate-production, lysozyme-sensitivity, nih
Organization: U.S. Department of Health & Human Services
2012 State Profile - Missouri

This is a National Survey of Substance Abuse Treatment Services (N-SSATS) annual report showing the state profile for Missouri in 2012. N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 States, the District of Columbia, and other U.S. jurisdictions.

Tags: alcohol-drug-treatment, missouri, n-ssats, samhsa, substance-abuse-treatment
Organization: U.S. Department of Health & Human Services
State Child Abuse and Neglect (SCAN) Policies Database 2023

Other data sources that can be linked with the  SCAN Policies Database include data from the National Child Abuse and Neglect Data System (NCANDS),  the Adoption and Foster Care Analysis and Reporting System (AFCARS), state administrative data, and survey data.  When data from the SCAN Policies Database are linked with other data sources, these data can be used to answer key research questions about how variations in definitions and policies are associated with key aspects of understanding the incidence of child abuse and neglect.

Investigators: Elizabeth C. Weigensberg, PhD - 
Mathematica
Nuzhat Islam, MS - 
Mathematica
Milena Raketic, M.Ed - Mathematica
Mary A. Grider, MBA - 
Mathematica
Jeremy Page, MA - 
Mathematica

Tags: abuse, care, ndacan, policy, reporting
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: HHS Region II, 2014

This is a behavioral health report for HHS Region II of the United States and utilizes data from the National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment (N-SSATS), collected annually. The topics addressed in the reports include youth substance use, youth mental health and substance use treatment.

Tags: samhsa, substance-use-treatment, survey, youth-mental-health, youth-substance-use
Organization: U.S. Department of Health & Human Services
Receipt of Services for Substance Use and Mental Health Issues among Adults: Results from the 2016 National Survey on Drug Use and Health

This report presents data from the 2016 NSDUH for substance use treatment and data from the 2002 through 2016 NSDUHs for mental health service use among adults aged 18 years old or older. Estimates for the receipt of substance use treatment are presented for young adults aged 18 to 25 and for adults aged 26 or older.

Tags: adult-mental-health, mental-health-services, nsduh-survey, samhsa, substance-use-treatment
Organization: U.S. Department of Health & Human Services