AndreaBozzo/ceres-open-data-index huggingface dataset:
Modulation of cathepsin G expression in severe atopic dermatitis following medium-dose UVA1 phototherapy

Background
          During the last decade, medium-dose UVA1 phototherapy (50 J/cm2) has achieved great value within the treatment of severe atopic dermatitis (AD). The purpose of our study was to investigate to what extent UVA1 irradiation is able to modulate the status of protease activity by the use of a monoclonal antibody labeling cathepsin G.
        
        
          Methods
          In order to further elucidate the mechanisms by which medium-dose UVA1 irradiation leads to an improvement of skin status in patients with AD, biopsy specimens from 15 patients before and after treatment were analyzed immunohistochemically for proteolytic activation.
        
        
          Results
          Compared to lesional skin of patients with AD before UVA1 irradiation, the number of cells positive for cathepsin G within the dermal infiltrate decreased significantly after treatment. The decrease of cathepsin G+ cells was closely linked to a substantial clinical improvement in skin condition.
        
        
          Conclusions
          In summary, our findings demonstrated that medium-dose UVA1 irradiation leads to a modulation of the expression of cathepsin G in the dermal inflammatory infiltrate in patients with severe AD. Cathepsin G may attack laminin, proteoglycans, collagen I and insoluble fibronectin, to provoke proinflammatory events, to degrade the basement membrane, to destroy the tissue inhibitor of metalloproteinases and to increase the endothelial permeability. Therefore, its down-regulation by UVA1 phototherapy may induce the reduction of skin inflammation as well as improvement of the skin condition.

Tags: atopic-dermatitis, cathepsin-g, immunohistochemistry, nih, uva1-phototherapy
Organization: U.S. Department of Health & Human Services
Ibuprofen 400 mg is effective in women, and women are well represented in trials

Background
          A recent article in the New Scientist argued that women were under-represented in clinical trials which, until now, had masked the finding that ibuprofen 400 mg was ineffective in women.
        
        
          Methods
          Meta-analysis of randomised, double-blind placebo-controlled trials of ibuprofen 400 mg in acute pain, and use of individual patient information were planned to test the hypothesis that ibuprofen is ineffective in women. For each trial the proportion of women participating, the number of patients with at least 50% pain relief and the overall event rate for ibuprofen 400 mg and placebo was calculated. For each patient percentage pain relief was calculated, and the numbers of women and men achieving at least 50% pain relief used to calculate number-needed-to-treat (NNT) for ibuprofen 400 mg compared to placebo.
        
        
          Results
          Thirty-seven included trials had 3,577 patients, 67% of whom were women. The proportion with at least 50% pain relief was unaffected by how many women were included. In an analysis of 678 individual patients the proportion of women and men with at least 50% pain relief was the same, NNT 3.4 (2.6 to 4.6) and 2.5 (2.0 to 3.3) respectively.
        
        
          Conclusion
          There is no clinically meaningful difference in the efficacy of ibuprofen 400 mg between men and women experiencing moderate to severe postoperative pain and women were well represented.

Tags: acute-pain-relief, gender-differences, ibuprofen-effectiveness, meta-analysis, nih
Organization: U.S. Department of Health & Human Services
"Bronchial Artery Delivery of Viral Vectors for Gene delivery in Cystic Fibrosis; Superior to Airway Delivery?"

Background
          Attempts at gene therapy for the pulmonary manifestations of Cystic Fibrosis have relied mainly on airway delivery. However the efficiency of gene transfer and expression in the airway epithelia has not reached therapeutic levels. Access to epithelial cells is not homogenous for a number of reasons and the submucosal glands cannot be reached via the airways.
        
        
          Presentation
          We propose to inject gene delivery vectors directly into bronchial arteries combined with pre-delivery of vascular endothelial growth factor to increase vascular endothelial permeability and post-delivery flow reduction by balloon occlusion. Thus it may be possible to reach mucous secreting cells of the bronchial luminal epithelium and the submucosal glands in an increased and homogenous fashion.
        
        
          Testing
          This combination of techniques to the best of our knowledge has not previously been investigated, and may enable us to overcome some of the current limitations to gene therapy for Cystic Fibrosis.

Tags: bronchial-artery-delivery, cystic-fibrosis, gene-therapy, nih, viral-vectors
Organization: U.S. Department of Health & Human Services
2023 Uniform Reporting System (URS) Table For South Carolina

This is the 2023 Uniform Reporting System (URS) Output Tables for South Carolina. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: mental-health-services, national-outcome-measures, samhsa, south-carolina, substance-abuse
Organization: U.S. Department of Health & Human Services
Sample Size and Population Estimates Tables (Prevalence Estimates) - 8.1 to 8.13

These detailed tables show sample sizes and population estimates from the 2011 National Survey on Drug Use and Health (NSDUH). Samples sizes and population estimates are provided by age group, gender, race/ethnicity, education level, employment status, geographic area, pregnancy status, college enrollment status, and probation/parole status.

Tags: nsduh-2011, population-estimates, samhsa, sample-size, substance-use
Organization: U.S. Department of Health & Human Services
2012 Uniform Reporting System (URS) Tables for Utah

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2012. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, mental-health-utilization, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
West Virginia (WV)

This report presents West Virginia\'s estimates for 25 measures of substance use and mental health based on the combined 2009 and 2010 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for West Virginia for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: mental-health, nsduh-data, samhsa, substance-use, west-virginia
Organization: U.S. Department of Health & Human Services
Elevated calcitonin precursor levels are related to mortality in an
		  animal model of sepsis

Background:
          Increased serum levels of procalcitonin (ProCT) and its component
				peptides have been reported in humans with sepsis. Using a hamster model of
				bacterial peritonitis, we investigated whether serum ProCT levels are elevated
				and correlate with mortality and hypocalcemia.
        
        
          Results:
          Incremental increases in doses of bacteria resulted in
				proportional increases in 72h mortality rates (0, 20, 70, and 100%) as well as
				increases in serum total immunoreactive calcitonin (iCT) levels at 12 h (250,
				380, 1960, and 4020 pg/ml, respectively, vs control levels of 21 pg/ml).
				Gel filtration studies revealed that ProCT was the predominant (> 90%)
				molecular form of serum iCT secreted. In the metabolic experiments, total iCT
				peaked at 12 h concurrent with the maximal decrease in serum calcium.
        
        
          Conclusions:
          In this animal model, hyper-procalcitoninemia was an early
				systemic marker of sepsis which correlated closely with mortality and had an
				inverse correlation with serum calcium levels.

Tags: bacterial-peritonitis, hamster-model, nih, procalcitonin-levels, sepsis-mortality
Organization: U.S. Department of Health & Human Services
Publications Using SAMHSA DataN-SUMHSS 2022 Questionnaire

This is the questionnaire for the 2022 National Substance Use and Mental Health Services Survey (N-SUMHSS). The N-SUMHSS is a voluntary annual survey of all active substance use and mental health facilities in the United States, its jurisdictions, and the District of Columbia. This document shows the series of questions mental health and substance abuse treatment facilities were asked for the N-SUMHSS.The survey consists of two introductory questions and four separate modules. Skip patterns in the survey direct participants on relevant modules depending on whether the facility is a substance use treatment facility, a mental health treatment facility, or both.Additionally, facilities operated by the Department of Veteran’s Affairs (VA) were asked to complete additional questions regarding VA services offered.The web questionnaire and other addenda are available as PDF files.

Tags: facility-survey, mental-health-services, n-sumhss, samhsa, substance-use-treatment
Organization: U.S. Department of Health & Human Services
Down-regulation of the alpha-2C adrenergic receptor: involvement of a serine/threonine motif in the third cytoplasmic loop

Background
          The mechanisms by which alpha-2 adrenergic receptors are down-regulated following chronic exposure to agonist are not well understood. Interestingly, the human alpha-2C receptor does not down-regulate, whereas the opossum alpha-2C receptor does down-regulate. A comparison of the amino acid sequence of the third intracellular loop of these two receptors shows that the opossum alpha-2C receptor contains a potential G protein-coupled receptor kinase (GRK)phosphorylation motif (EESSTSE) with four hydroxyl residues, whereas the human alpha-2C receptor motif only contains two hydroxyl residues (DESSAAAAE). Because a similar acidic serine-rich motif (EESSSSD) in the human alpha-2 adrenergic receptor has been demonstrated to be phosphorylated by GRK and all four serines are required for desensitization of the receptor, we sought to determine whether the EESSTSE sequence was involved in the down-regulation of the alpha-2C adrenergic receptor.
        
        
          Results
          Site-directed mutagenesis was used to mutate the opossum alpha-2C receptor to SSVA and AAVA in place of the SSTS wild-type sequence. Down-regulation experiments on CHO cells transfected with the receptors demonstrated that neither of the mutated receptors down-regulated following 24 h exposure to norepinephrine, whereas the wild-type receptor down-regulated to 65 ± 10% of the control.
        
        
          Conclusions
          These results indicate that a motif with four hydroxyl amino acid residues in an acidic environment is important for down-regulation of the opossum alpha-2C adrenergic receptor. Because these are potential GRK phosphorylation sites, we suggest that GRK phosphorylation may be involved in alpha-2C adrenergic receptor down-regulation.

Tags: alpha-2c-adrenergic, grk-phosphorylation, nih, receptor-downregulation, serine-threonine-motif
Organization: U.S. Department of Health & Human Services
What you should know about PR3-ANCA: Conformational requirements of proteinase 3 (PR3) for enzymatic activity and recognition by PR3-ANCA

The neutrophil azurophil granule constituent proteinase 3 (PR3) is the principal antigen for anti-neutrophil cytoplasmic antibodies (ANCA) in Wegener's granulomatosis. The conformation of the mature PR3 enzyme results from intracellular post-translational processing. The nascent molecule undergoes proteolytic cleavage of the amino-terminal signal peptide and activation dipeptide and of a carboxy-terminal peptide extension. The conformation of PR3 is stabilized by four disulfide bonds and, to a lesser extent, by asparagine-linked glycosylation. Most anti-neutrophil cytoplasmic antibodies directed against proteinase 3 (PR3-ANCA) recognize conformational epitopes. The expression of recombinant PR3 has provided a better understanding of the significance of the various intracellular processing steps for enzymatic activity and recognition by PR3-ANCA.

Tags: anca-specificity, autoantibody-recognition, nih, proteinase-3, wegeners-granulomatosis
Organization: U.S. Department of Health & Human Services
2022 Uniform Reporting System (URS) Table For Delaware

This is the 2022 Uniform Reporting System (URS) Output Tables for Delaware. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-program, evidence-based-practices, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
A prospective study of tracheopulmonary complications associated with the placement of narrow-bore enteral feeding tubes

Background:
          In order to determine the type and incidence of pulmonary complications associated with the placement of narrow-bore enteral feeding tubes we conducted a prospective, descriptive study in the multidisciplinary intensive care unit (ICU) of a university hospital. All patients that had narrow-bore enteral feeding tubes inserted over a 2-year period (1993-1995) were included. The study required no clinical interventions.
        
        
          Results:
          Seven hundred and forty feeding tubes were inserted during the study period. In 14 cases (2%), the feeding tube was inserted into the tracheopulmonary system. Five patients (0.7%) suffered a major complication, including two (0.3%) who died from complications directly related to the feeding tube placement. All patients had altered consciousness and 13 of the 14 had endotracheal tubes in place. Malposition of the feeding tube was not predictable from clinical signs and auscultation, but was detectable by chest roentgenogram.
        
        
          Conclusions:
          Inadvertent insertion of enteral feeding tubes into the tracheopulmonary system during placement is associated with significant morbidity and mortality. Clinical signs at the time of insertion are not useful in identifying feeding tubes which are malpositioned. In the ICU patient, a chest roentgenogram is required after all feeding tube insertions prior to the initiation of enteral feeding. In the high-risk patient, alternatives to blind feeding tube insertion should be considered.

Tags: enteral-feeding-tubes, icu-patients, nih, tracheopulmonary-complications, tube-malposition
Organization: U.S. Department of Health & Human Services
Compound 525341: 1,4-Dithiepane

Chemical compound data from PubChem database. IUPAC Name: 1,4-dithiepane. Molecular Formula: C5H10S2. Molecular Weight: 134.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
National Directory of Drug and Alcohol Abuse Treatment Programs 2013

This is a National Survey of Substance Abuse Treatment Services (N-SSATS) annual report that includes the National Directory of Drug and Alcohol Abuse Treatment Programs in 2013. The National Directory of Drug and Alcohol Abuse Treatment Program is a listing of Federal, State, and local government facilities and private facilities that provide substance abuse treatment services. It includes treatment facilities that (1) are licensed, certified, or otherwise approved for inclusion in the Directory by their State substance abuse agencies, and (2) responded to the 2012 National Survey of Substance Abuse Treatment Services (N-SSATS). N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 States, the District of Columbia, and other U.S. jurisdictions.

Tags: alcohol-abuse-treatment, n-ssats, samhsa, substance-abuse-treatment, treatment-facility-directory
Organization: U.S. Department of Health & Human Services
2022-2023 NSDUH Data Brief: Illegally Made Fentanyl Use in the United States

This data brief presents findings from the 2022 and 2023 National Surveys on Drug Use and Health (NSDUHs) on illegally made fentanyl (IMF) use among the noninstitutionalized, civilian U.S. population.

Tags: fentanyl-use, illicit-fentanyl, nsduh-data, samhsa, substance-use-survey
Organization: U.S. Department of Health & Human Services
Phenotypic characteristics of human monocytes undergoing transendothelial migration

In our study we characterised the immunophenotype of monocytes that migrated through an endothelial cell (EC) monolayer in vitro. We found that monocyte migration led to an enhanced expression of CD11a, CD33, CD45RO, CD54 [intercellular cell-adhesion molecule (ICAM)-1] and human leucocyte antigen-DR. The most striking increase was observed for ICAM-1 when ECs were activated with tumour necrosis factor-α and interleukin-1α. The results of our study indicate the following: (1) there is a characteristic immunophenotype on the surface of monocytes after transendothelial migration; (2) this phenotype seems to be induced by interactions between monocytes and ECs; and (3) this change is enhanced by the pretreatment of ECs with cytokines. Taken together, the results suggest that local cytokine production activating ECs is sufficient to enhance monocyte migration and that this, in turn, can induce changes consistent with an activated phenotype known to be interactive between antigen-presenting cells and T cells. These results have implications for our pathogenetic insights into rheumatoid arthritis.

Tags: cell-adhesion, immunophenotyping, monocyte-migration, nih, transendothelial-migration
Organization: U.S. Department of Health & Human Services
Compound 527344: 14,18,22,26-Tetramethyl-nonacosyl cyanide

Chemical compound data from PubChem database. IUPAC Name: 15,19,23,27-tetramethyltriacontanenitrile. Molecular Formula: C34H67N. Molecular Weight: 489.9. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2019 Uniform Reporting System (URS) Table for District of Columbia

These are the 2019 Uniform Reporting System (URS) Output Tables for District of Columbia. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, evidence-based-practices, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
2012 Uniform Reporting System (URS) Tables for Hawaii

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2012. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, hawaii-mental-health, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Wisconsin (WI)

This report presents Wisconsin\'s estimates for 25 measures of substance use and mental health based on the combined 2009 and 2010 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for Wisconsin for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: mental-health, nsduh-data, samhsa, substance-use, wisconsin-health
Organization: U.S. Department of Health & Human Services
2021 Uniform Reporting System (URS) Table For New York

This is the 2021 Uniform Reporting System (URS) Output Tables for New York. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-program, evidence-based-practices, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
The DAWN Report: Emergency Department Visits Involving Attention Deficit/Hyperactivity Disorder Stimulant Medications

This Drug Abuse Warning Network (DAWN) short report shows the estimated number of emergency room visits involving attention deficit/hyperactivity disorder stimulant medications between 2005 and 2010. The report shows visits for nonmedical use, adverse reactions, visits involving other pharmaceuticals, illicit drugs or alcohol.

Tags: adhd-stimulants, adverse-drug-events, emergency-department, nonmedical-use, samhsa
Organization: U.S. Department of Health & Human Services
Phoenix: Drug-Related Emergency Department Visits, 2004-2011 - Nonmedical Use of Pharmaceuticals

Excel file with estimates, rates, relative standard errors, trends and confidence intervals for all drug-related emergency department (ED) visits involving the nonmedical use of pharmaceuticals (prescription and over-the-counter medications and dietary supplements) for the Phoenix metropolitan area, covering 2004-2011.  Nonmedical use includes patients who took a higher than prescribed or recommended dose of their own medication, patients who took a pharmaceutical prescribed for another person, malicious poisoning of the patient by another individual, and documented substance abuse involving pharmaceuticals

Tags: drug-related-ed, emergency-department-visits, pharmaceutical-misuse, phoenix-metro-area, samhsa
Organization: U.S. Department of Health & Human Services