AndreaBozzo/ceres-open-data-index huggingface dataset:
Equipment review: Intrahospital transport of critically ill patients

Background
          This review on the current literature of the intrahospital				transport of critically ill patients addresses type and incidence of adverse				effects, risk factors and risk assessment, and the available information on				efficiency and cost-effectiveness of transferring such patients for diagnostic				or therapeutic interventions within hospital. Methods and guidelines to prevent				or reduce potential hazards and complications are provided.
        
        
          Methods
          A Medline search was performed using the terms 'critical				illness', 'transport of patients', 'patient				transfer', 'critical care', 'monitoring' and				'intrahospital transport', and all information concerning the				intrahospital transport of patients was considered.
        
        
          Results
          Adverse effects may occur in up to 70% of transports. They include				a change in heart rate, arterial hypotension and hypertension, increased				intracranial pressure, arrhythmias, cardiac arrest and a change in respiratory				rate, hypocapnia and hypercapnia, and significant hypoxaemia. No				transport-related deaths have been reported. In up to one-third of cases				mishaps during transport were equipment related. A long-term deterioration of				respiratory function was observed in 12% of cases. Patient-related risk				indicators were found to be a high Therapeutic Intervention Severity Score,				mechanical ventilation, ventilation with positive end-expiratory pressure and				high injury severity score. Patients' age, duration of transport,				destination of transport, Acute Physiology and Chronic Health Evaluation II				score, personnel accompanying the patient and other factors were not found to				correlate with an increased rate of complications. Transports for diagnostic				procedures resulted in a change in patient management in 40-50% of cases,				indicating a good risk:benefit ratio.
        
        
          Conclusions
          To prevent adverse effects of intrahospital transports, guidelines				concerning the organization of transports, the personnel, equipment and				monitoring should be followed. In particular, the presence of a critical care				physician during transport, proper equipment to monitor vital functions and to				treat such disturbances immediately, and close control of the patient's				ventilation appear to be of major importance. It appears useful to use				specifically constructed carts including standard intensive care unit				ventilators in a selected group of patients. To further reduce the rate of				inadvertent mishaps resulting from transports, alternative diagnostic				modalities or techniques and performing surgical procedures in the intensive				care unit should be considered.

Tags: adverse-events, critical-illness, intrahospital-transport, nih, patient-safety
Organization: U.S. Department of Health & Human Services
2013 CMHS Uniform Reporting System (URS) Tables for Georgia

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Tables for Georgia for 2013. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program.  State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: georgia-mental-health, mental-health-services, noms-data, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
Compound 525604: N,N-Dimethyl-N'-(4-methylphenyl)-p-methoxybenzamidine

Chemical compound data from PubChem database. IUPAC Name: 4-methoxy-N,N-dimethyl-N'-(4-methylphenyl)benzenecarboximidamide. Molecular Formula: C17H20N2O. Molecular Weight: 268.35. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 527370: 2,28-Dimethyl-triacontyl cyanide

Chemical compound data from PubChem database. IUPAC Name: 3,29-dimethylhentriacontanenitrile. Molecular Formula: C33H65N. Molecular Weight: 475.9. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Role of delta-tubulin and the C-tubule in assembly of

Background
          A breakthrough in the understanding of centriole assembly was provided by the characterization of the UNI3 gene in Chlamydomonas. Deletion of this gene, found to encode a novel member of the tubulin superfamily, delta-tubulin, results in the loss of the C-tubule, in the nine microtubule triplets which are the hallmark of centrioles and basal bodies. Delta-tubulin homologs have been identified in the genomes of mammals and protozoa, but their phylogenetic relationships are unclear and their function is not yet known.
        
        
          Results
          Using the method of gene-specific silencing, we have inactivated the Paramecium delta-tubulin gene, which was recently identified. This inactivation leads to loss of the C-tubule in all basal bodies, without any effect on ciliogenesis. This deficiency does not directly affect basal body duplication, but perturbs the cortical cytoskeleton, progressively leading to mislocalization and loss of basal bodies and to altered cell size and shape. Furthermore, additional loss of B- and even A-tubules at one or more triplet sites are observed: around these incomplete cylinders, the remaining doublets are nevertheless positioned according to the native ninefold symmetry.
        
        
          Conclusions
          The fact that in two distinct phyla, delta-tubulin plays a similar role provides a new basis for interpreting phylogenetic relationships among delta-tubulins. The role of delta-tubulin in C-tubule assembly reveals that tubulins contribute subtle specificities at microtubule nucleation sites. Our observations also demonstrate the existence of a prepattern for the ninefold symmetry of the organelle which is maintained even if less than 9 triplets develop.

Tags: basal-bodies, c-tubule, centriole-assembly, delta-tubulin, nih
Organization: U.S. Department of Health & Human Services
Compound 527364: 18,22-Dimethyl-dotriacontyl cyanide

Chemical compound data from PubChem database. IUPAC Name: 19,23-dimethyltritriacontanenitrile. Molecular Formula: C35H69N. Molecular Weight: 503.9. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
A prospective randomised pilot study of sedation regimens in a general ICU population: a reality-based medicine study

Background:
          For logistical reasons sedation studies are often carried out in elective surgical patients and the results extrapolated to the general intensive care unit (ICU) population. We question the validity of this approach. We compared the two sedation regimens used in our general ICU in a trial structured to mimic clinical practice as closely as possible.
        
        
          Results:
          Forty patients were randomised to intermittent diazepam or continuous midazolam and sedation monitored with hourly sedation scores; 31 patients completed the study. Scores indicating undersedation were more common with diazepam (P <0.01); overall adequate sedation midazolam 64.7%, diazepam 35.7% (P =0.21). No patient exhibited inappropriately prolonged sedation. Cost was: midazolam AUS$1.98/h; diazepam AUS$0.06/h.
        
        
          Conclusion:
          Both regimens produced rapid onset of acceptable sedation but undersedation appeared more common with the cheaper diazepam regimen. At least 140 patients should be studied to provide evidence applicable to the general ICU population. Used alone, a sedation score may be an inappropriate outcome measure for a sedation trial.

Tags: critical-care, icu-sedation, midazolam-diazepam, nih, sedation-regimens
Organization: U.S. Department of Health & Human Services
Genome trees constructed using five different approaches suggest new major bacterial clades

Background
          The availability of multiple complete genome sequences from diverse taxa prompts the development of new phylogenetic approaches, which attempt to incorporate information derived from comparative analysis of complete gene sets or large subsets thereof. Such attempts are particularly relevant because of the major role of horizontal gene transfer and lineage-specific gene loss, at least in the evolution of prokaryotes.
        
        
          Results
          Five largely independent approaches were employed to construct trees for completely sequenced bacterial and archaeal genomes: i) presence-absence of genomes in clusters of orthologous genes; ii) conservation of local gene order (gene pairs) among prokaryotic genomes; iii) parameters of identity distribution for probable orthologs; iv) analysis of concatenated alignments of ribosomal proteins; v) comparison of trees constructed for multiple protein families. All constructed trees support the separation of the two primary prokaryotic domains, bacteria and archaea, as well as some terminal bifurcations within the bacterial and archaeal domains. Beyond these obvious groupings, the trees made with different methods appeared to differ substantially in terms of the relative contributions of phylogenetic relationships and similarities in gene repertoires caused by similar life styles and horizontal gene transfer to the tree topology. The trees based on presence-absence of genomes in orthologous clusters and the trees based on conserved gene pairs appear to be strongly affected by gene loss and horizontal gene transfer. The trees based on identity distributions for orthologs and particularly the tree made of concatenated ribosomal protein sequences seemed to carry a stronger phylogenetic signal. The latter tree supported three potential high-level bacterial clades,: i) Chlamydia-Spirochetes, ii) Thermotogales-Aquificales (bacterial hyperthermophiles), and ii) Actinomycetes-Deinococcales-Cyanobacteria. The latter group also appeared to join the low-GC Gram-positive bacteria at a deeper tree node. These new groupings of bacteria were supported by the analysis of alternative topologies in the concatenated ribosomal protein tree using the Kishino-Hasegawa test and by a census of the topologies of 132 individual groups of orthologous proteins. Additionally, the results of this analysis put into question the sister-group relationship between the two major archaeal groups, Euryarchaeota and Crenarchaeota, 
and suggest instead that Euryarchaeota might be a paraphyletic group with respect to Crenarchaeota.
        
        
          Conclusions
          We conclude that, the extensive horizontal gene flow and lineage-specific gene loss notwithstanding, extension of phylogenetic analysis to the genome scale has the potential of uncovering deep evolutionary relationships between prokaryotic lineages.

Tags: bacterial-genomes, genome-phylogeny, genome-trees, nih, phylogenetic-analysis
Organization: U.S. Department of Health & Human Services
Compound 527337: 2-(3,4-Dimethylphenyl)adamantane

Chemical compound data from PubChem database. IUPAC Name: 2-(3,4-dimethylphenyl)adamantane. Molecular Formula: C18H24. Molecular Weight: 240.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Is age an independent determinant of mortality in cardiac surgery as suggested by the EuroSCORE?

Background
          The proportion of older patients in cardiac surgery is continuously increasing. 37% of patients undergoing heart surgery in Germany in the year 2000 were 70 years of age and older. We have studied the role of age as a determinant of mortality in cardiac surgery in our institutional patient population.
        
        
          Methods
          We have calculated the EuroSCORE and the corresponding age-adjusted EuroSCORE in 8769 patients who underwent heart surgery between January 1996 and January 2002 and collected the information on the occurrence of postoperative complications and 30-days mortality.
        
        
          Results
          The multimorbidity increased with ascending age. Both the EuroSCORE and the age-adjusted EuroSCORE values increased significantly with age in the whole group of patients as well as in the group of patients who were alive 30 days after heart surgery. The incidence of postoperative complications and 30-days mortality increased significantly with age. In patients who died within 30 days after surgery, the EuroSCORE increased significantly with age, whereas the age-adjusted EuroSCORE did not. The occurrence of diabetes mellitus, arterial hypertension and atrial fibrillation, i.e., the risk factors not considered by the EuroSCORE, exhibited a significant age dependence in our patients. The univariate analysis identified the significant dependence of 30-days mortality on diabetes and atrial fibrillation. The stepwise logistic regression analysis showed the dependence of mortality on diabetes.
        
        
          Conclusions
          On the background of the well-known age-dependent structural and functional changes of different body organs, our data show that age is a significant risk indicator in cardiac surgery, strongly correlating with morbidity and mortality. Consequently, special preventive and therapeutic measures are required in clinical environment in the case of elderly patients undergoing cardiac surgery.

Tags: age-factors, cardiac-surgery, euroscore-risk, mortality-risk, nih
Organization: U.S. Department of Health & Human Services
Effects of an angiotensin II antagonist on organ perfusion during the post-resuscitation phase in pigs

Background:
          The aim of this study was to compare pre-arrest and post-resuscitation organ perfusion values and to investigate whether, during the post-resuscitation phase, administration of the angiotensin II antagonist telmisartan (TELM) 10 min after restoration of spontaneous circulation (ROSC) could improve organ flow in comparison to placebo.
        
        
          Results:
          Five minutes after ROSC in the TELM group, blood flow in the cortex and myocardium increased to 583% (P < 0.05) and 137% (not significant), respectively, whereas blood flow of the colon, stomach and pancreas decreased to 50% (P < 0.05), 28% (P < 0.05) and 19% (P < 0.05) of pre-arrest values, respectively. At 90 min after ROSC, pre-arrest perfusion values both in non-splanchnic and splanchnic organs were achieved. At no point in time were there significant differences between the two groups with respect to organ blood flow or speed of recovery of organ perfusion.
        
        
          Conclusions:
          During the post-resuscitation phase, organ blood flow is characterized by the coincidence of increased cerebral and myocardial blood flow and decreased intestinal blood flow. Administration of TELM 10 min after ROSC did not improve the recovery of organ perfusion.

Tags: cardiopulmonary-resuscitation, nih, organ-perfusion, post-resuscitation-syndrome, telmisartan-effects
Organization: U.S. Department of Health & Human Services
Wyoming 2016 Potential Areas for Addressing Service Gaps for Opioid Treatment

The purpose of the medication-assisted treatment (MAT) facility maps is to identify areas on a state-by-state basis that may be potentially underserved by existing treatment facilities. The maps are created with a methodology that seeks to include the highest potential need areas from individual counties so that county-level stakeholders are also informed. The maps are meant to be used as a tool for policy makers to determine potentially underserved areas—not as a definitive representation of these areas.

Tags: mat-access, opioid-treatment, samhsa, service-gaps, wyoming
Organization: U.S. Department of Health & Human Services
Antinociceptive and anti-inflammatory effects of

Background
          Crocus sativus L. (saffron) is used in folk medicine, for example as an antiedematogenic agent. We aimed to evaluate the antinociceptive and anti-inflammatory activity of saffron extracts in mice.
        
        
          Results
          We used aqueous and ethanolic maceration extracts of Crocus sativus L. stigma and petals. Antinociceptive activity was examined using the hot plate and writhing tests. The effect of extracts against acute inflammation was studied using xylene induced ear edema in mice. The activity of the extracts against chronic inflammation was assessed by formalin-induced edema in the rat paw. In the hot plate tests, intraperitoneal injection of both extracts showed no significant antinociceptive activity in mice. The extracts exhibited antinociceptive activity against acetic acid induced writhing. Naloxone partially blocked only the antinociceptive activity of the stigma aqueous extract. Only the stigma extracts showed weak to moderate effect against acute inflammation. In chronic inflammation, both aqueous and ethanolic stigma extracts, as well as ethanolic petal extract, exerted anti-inflammatory effects.
        
        
          Conclusions
          We conclude that aqueous and ethanolic extracts of saffron stigma and petal have an antinociceptive effect, as well as acute and/or chronic anti-inflammatory activity.

Tags: anti-inflammatory, antinociception, crocus-sativus, nih, saffron-extracts
Organization: U.S. Department of Health & Human Services
Table 15. Perceptions of Great Risk from Smoking One or More Packs of Cigarettes per Day, by Age Group and State: Percentages, Annual Averages Based on 2013 and 2014 NSDUHs

Table 15. Perceptions of Great Risk from Smoking One or More Packs of Cigarettes per Day, by Age Group and State: Percentages, Annual Averages Based on 2013 and 2014 NSDUHs

Tags: adolescent-health, cigarette-use, nsduh-data, samhsa, smoking-risk-perception
Organization: U.S. Department of Health & Human Services
Preoperative prediction of pediatric patients with effusions and edema following cardiopulmonary bypass surgery by serological and routine laboratory data

Aim
          Postoperative effusions and edema and capillary leak syndrome in children after cardiac surgery with cardiopulmonary bypass constitute considerable clinical problems. Overshooting immune response is held to be the cause. In a prospective study we investigated whether preoperative immune status differences exist in patients at risk for postsurgical effusions and edema, and to what extent these differences permit prediction of the postoperative outcome.
        
        
          Method
          One-day preoperative serum levels of immunoglobulins, complement, cytokines and chemokines, soluble adhesion molecules and receptors as well as clinical chemistry parameters such as differential counts, creatinine, blood coagulation status (altogether 56 parameters) were analyzed in peripheral blood samples of 75 children (aged 3–18 years) undergoing cardiopulmonary bypass surgery (29 with postoperative effusions and edema within the first postoperative week).
        
        
          Results
          Preoperative elevation of the serum level of C3 and C5 complement components, tumor necrosis factor-α, percentage of leukocytes that are neutrophils, body weight and decreased percentage of lymphocytes (all P < 0.03) occurred in children developing postoperative effusions and edema. While single parameters did not predict individual outcome, >86% of the patients with postoperative effusions and oedema were correctly predicted using two different classification algorithms. Data mining by both methods selected nine partially overlapping parameters. The prediction quality was independent of the congenital heart defect.
        
        
          Conclusion
          Indicators of inflammation were selected as risk indicators by explorative data analysis. This suggests that preoperative differences in the immune system and capillary permeability status exist in patients at risk for postoperative effusions. These differences are suitable for preoperative risk assessment and may be used for the benefit of the patient and to improve cost effectiveness.

Tags: cardiopulmonary-bypass, nih, pediatric-cardiac-surgery, postoperative-effusions, serological-markers
Organization: U.S. Department of Health & Human Services
2016 Uniform Reporting System (URS) Table for Northern Mariana Islands

This is the 2016 Uniform Reporting System (URS) Output Tables for Northern Mariana Islands. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant, mental-health-services, northern-mariana-islands, outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
National Directory of Drug and Alcohol Abuse Treatment Facilities - 1995

The National Directory of Drug and Alcohol Abuse Treatment Programs 1996 lists federal, state, local, and private facilities that provide substance abuse treatment services. The directory includes treatment facilities that are licensed, certified, or otherwise approved for inclusion in the directory by their state substance abuse agencies and that responded to the 1994 National Survey of Substance Abuse Treatment Services (N-SSATS). The information about each facility that appears in this directory was provided by that facility in response to the 1994 N-SSATS. The Substance Abuse and Mental Health Services Administration (SAMHSA) conducts the N-SSATS annually.

Tags: alcohol-abuse-treatment, n-ssats, samhsa, substance-abuse-treatment, treatment-facilities
Organization: U.S. Department of Health & Human Services
2015 CMHS Uniform Reporting System (URS) Table for Nevada

2015 Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for Nevada.  The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-data, mental-health-services, nevada-mental-health, noms-measures, samhsa
Organization: U.S. Department of Health & Human Services