AndreaBozzo/ceres-open-data-index huggingface dataset:
IFN-gamma transgenic mice: clues to the pathogenesis of systemic lupus erythematosus?

Transgenic mice overexpressing IFN-γ in the epidermis develop an inflammatory skin disease resembling cutaneous lupus erythematosus shortly after birth. By 3 months of age, most female transgenics develop a lupus-like syndrome characterised by production of IgG anti-dsDNA, antihistone and antinucleosome autoantibodies. The autoantibodies are nephritogenic, with one-third of females developing a severe immune complex mediated glomerulonephritis. Analysis of these transgenics suggests that pathogenic autoantibodies arise via an antigen-driven T-cell-dependent mechanism with apoptotic keratinocytes acting as a potential source of autoantigen. The mechanism of autoantibody production in IFN-γ transgenics may be relevant to human lupus and is consistent with a central role for cutaneous T cells in the pathogenesis of systemic lupus erythematosus in man.

Tags: autoantibodies, ifn-gamma, nih, systemic-lupus-erythematosus, transgenic-mice
Organization: U.S. Department of Health & Human Services
Socio-demographic factors and self-reported funtional status: the significance of social support

Background
          The aim of the present work was to investigate the relative importance of socio-demographic and physical health status factors for subjective functioning, as well as to examine the role of social support.
        
        
          Methods
          A cross-sectional health survey was carried out in a Greek municipality. 1356 adults of the general population were included in the study. Personal interviews were conducted with house-to-house visits. The response rate was 91.2%. Functioning has been measured by five indexes: 'The Social Roles and Mobility' scale (SORM), 'The Self-Care Restrictions' scale (SCR), 'The Serious Limitations' scale (SL), 'The Minor Self-care Limitations' scale (MSCR) and 'The Minor Limitations in Social Roles and Mobility' scale (MSORM).
        
        
          Results
          Among the two sets of independent variables, the socio-demographic ones had significant influence on the functional status, except for MSORM. Allowing for these variables, the physical health status indicators had also significant effects on all functioning scales. Living arrangements and marital status had significant effects on four out of five indexes, while arthritis, Parkinson's disease, past stroke and kidney stones had significant effects on the SCR and SL scales.
        
        
          Conclusions
          These results suggest that socio-demographic factors are as important as physical health variables in affecting a person's ability to function normally in their everyday life. Social support appears to play a significant role in explaining differences in subjective functioning: people living alone or only with the spouse, particularly the elderly, seem to be in greater risk for disability problems and should be targeted by preventive programs in the community.

Tags: cross-sectional-survey, functional-status, greek-population, nih, social-support
Organization: U.S. Department of Health & Human Services
2016 Uniform Reporting System (URS) Table for Louisiana

This is the 2016 Uniform Reporting System (URS) Output Tables for Louisiana. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-data, mental-health-services, national-outcome-measures, samhsa, substance-abuse-treatment
Organization: U.S. Department of Health & Human Services
2019 Uniform Reporting System (URS) Table for Arkansas

These are the 2019 Uniform Reporting System (URS) Output Tables for Arkansas. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: arkansas, block-grant-data, mental-health-services, noms-measures, samhsa
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Kansas, 2015

This is a behavioral health report for the state of Kansas. The report utilizes data from the National Survey on Drug Use and Health (NSDUH), and the Uniform Reporting System. The topics addressed in the report include youth substance use, youth mental health and treatment, mental health and treatment, substance use and substance use treatment.

Tags: kansas-behavioral-health, mental-health-treatment, nsduh-data, samhsa, youth-substance-use
Organization: U.S. Department of Health & Human Services
Genomic organization and single-nucleotide polymorphism map of desmuslin, a novel intermediate filament protein on chromosome 15q26.3

Background
          Desmuslin is an α-dystrobrevin-interacting protein expressed primarily in heart and skeletal muscle. The desmuslin protein interacts with and is closely related to desmin, a protein encoded by a locus mutated in some forms of hereditary distal myopathy. As a muscle-specific intermediate filament protein, desmuslin is also a candidate for myopathies of unknown etiology.
        
        
          Results
          The desmuslin gene was localized to chromosome 15q26.3 by electronic screening of the human DNA sequence database. Primer pairs were designed to amplify the 5 exons of the desmuslin gene in 11 overlapping DNA segments. The desmuslin gene was screened for mutations in 71 patients with various forms of myopathy for which there was no known cause. In this analysis, 10 common and 2 rare amino acid altering single-nucleotide polymorphisms were identified, all of which were seen in a control population of individuals thus making these unlikely causes of the phenotype. Interestingly, one of the single-nucleotide polymorphisms found in a patient resulted in a premature stop codon in the first exon. The nonsense mutation was also detected in the patient's unaffected father and one unaffected control; it was detected in 0.44% (2/454) of unrelated chromosomes and is therefore predicted to have a homozygous frequency of 0.002%.
        
        
          Conclusion
          No causative mutations were found in the desmuslin gene. However, the single-nucleotide polymorphisms mapped in this study represent a well-mapped group that can be used for disequilibrium studies of this region of chromosome 15q26.3.

Tags: desmuslin-gene, muscle-protein, myopathy-research, nih, single-nucleotide-polymorphism
Organization: U.S. Department of Health & Human Services
Compound 528553: Octadecane, 2,6,10,15-tetramethyl

Chemical compound data from PubChem database. IUPAC Name: 2,6,10,15-tetramethyloctadecane. Molecular Formula: C22H46. Molecular Weight: 310.6. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 525053: 1-Heptanamine, 1-methyl, N-ethyl

Chemical compound data from PubChem database. IUPAC Name: N-ethyloctan-2-amine. Molecular Formula: C10H23N. Molecular Weight: 157.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Isozyme and allozyme markers distinguishing two morphologically similar, medically important

Background
          Two common southern African mice species, Mastomys coucha and M. natalensis, are widely distributed throughout the subregion and overlap in many areas. They also share a high degree of morphological similarity, making them impossible to distinguish in the field at present. These multimammate mice are documented carriers of serious disease vectors causing Lassa fever, plague and encephalomyocarditis, which coupled to their cohabitation with humans in many areas, could pose a significant health risk. A preliminary study reported the presence of isozyme markers at three loci (GPI-2, PT-2, -3) in one population each of M. coucha and M. natalensis. Two additional populations (from the Vaal Dam and Richards Bay) were sampled to determine the reliability of these markers, and to seek additional genetic markers.
        
        
          Results
          Fifteen proteins or enzymes provided interpretable results at a total of 39 loci. Additional fixed allele differences between the species were detected at AAT-1, ADH, EST-1, PGD-1, Hb-1 and -2. Average heterozygosities for M. coucha and M. natalensis were calculated as 0.018 and 0.032 respectively, with a mean genetic distance between the species of 0.26.
        
        
          Conclusions
          The confirmation of the isozyme and the detection of the additional allozyme markers are important contributions to the identification of these two medical and agricultural pest species.

Tags: disease-vectors, isozyme-markers, mastomys-coucha, mastomys-natalensis, nih
Organization: U.S. Department of Health & Human Services
2013 NSDUH Editing & Imputation Report

This report focuses on the editing and statistical imputation procedures that were applied to respondent data for the 2013 NSDUH. Logical editing uses data from elsewhere within the same respondent's record to reduce the occurrence of missing or ambiguous data or to resolve inconsistencies between related variables. Imputation is defined as the replacement of missing values with valid, nonmissing values. Statistical imputation usually involves some randomness to preserve the natural variability in the data.

Tags: data-editing, data-imputation, missing-data, samhsa, statistical-methods
Organization: U.S. Department of Health & Human Services
Compound 527282: Citronellyl heptanoate

Chemical compound data from PubChem database. IUPAC Name: 3,7-dimethyloct-6-enyl heptanoate. Molecular Formula: C17H32O2. Molecular Weight: 268.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Treatment Episode Data Set  (TEDS): 2005-2015, National Admissions to Substance Abuse Treatment Services

This report presents national-level data from the Treatment Episode Data Set (TEDS) for admissions in 2015 and trend data from 2005 to 2015. It is a companion to the report Treatment Episode Data Set (TEDS): 2005-2015 State Admissions to Substance Abuse Treatment. These reports provide information on the demographic and substance abuse characteristics of admissions aged 12 and older to treatment for abuse of alcohol and/or drugs in facilities that report to individual state administrative data systems. Data include records for admissions during calendar years 2005 through 2015 that were received and processed through November 1, 2016.

Tags: alcohol-drug-abuse, samhsa, substance-abuse-treatment, teds-admissions, treatment-episodes
Organization: U.S. Department of Health & Human Services
Mental Health Service Use Of Youth Leaving Foster Care (Voyages) 2001-2003

The study was funded to explore the changes in mental health service use as older youth leave the foster care system. The data, however, examine many parameters of the lives of older youth in the foster care system, from their perspective. Four-hundred six youth in the Missouri foster care system were interviewed in person near their 17th birthday. They were re-interviewed when possible every three months until their 19th birthday. Eighty percent of the youth were interviewed at age 19. Thus, the study includes nine data points.  Domains of instrumentation include psychiatric history, substance use, child maltreatment history, mental health service use, attitudes toward mental health service use, residential history, religious involvement, reading level, dating violence, trauma history, stress, perception of neighborhood, psychopathy, employment, legal involvement, childbearing, sexual activity, and much more. Few variables were assessed at each interview time point.

Investigators: Curtis McMillen, Ph.D.
Washington University St. Louis, MO

Lionel D Scott, Ph.D.Huntsville, AL


Wendy Fran Auslander, Ph.D.
Washington University ST. Louis, MI

Tags: abuse, care, ndacan, policy, reporting
Organization: U.S. Department of Health & Human Services
The baboon (

Background
          As novel endovascular strategies are developed for treating neurological disease, there is an increasing need to evaluate these techniques in relevant preclinical models. The use of non-human primates is especially critical given their structural and physiological homology with humans. In order to conduct primate endovascular studies, a comprehensive understanding of the carotid anatomy is necessary. We therefore performed a detailed examination of the vessel lengths, lumen diameters and angles of origin of the baboon extracranial carotid system.
        
        
          Methods
          We characterized the extracranial carotid system often male baboons (Papio anubis, range 15.1–28.4 kg) by early post-mortem dissection. Photographic documentation of vessel lengths, lumen diameters, and angles of origin were measured for each segment of the carotid bilaterally.
        
        
          Results
          The common carotid arteries averaged 94.7 ± 1.7 mm (left) and 87.1 ± 1.6 mm (right) in length. The average minimal common carotid lumen diameters were 3.0 ± 0.3 mm (left) and 2.9 ± 0.2 mm (right). Each animal had a common brachiocephalic artery arising from the aorta which bifurcated into the left common carotid artery and right braciocephalic artery after 21.5 ± 1.6 mm. The vascular anatomy was found to be consistent among animals despite a wide range of animal weights.
        
        
          Conclusions
          The consistency in the Papio anubis extracranial carotid system may promote the use of this species in the preclinical investigation of neuro-interventional therapies.

Tags: baboon-carotid-anatomy, endovascular-model, nih, non-human-primate, vascular-morphometry
Organization: U.S. Department of Health & Human Services
2010 CMHS Uniform Reporting System (URS) Output Tables for West Virginia

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2010. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, national-outcome-measures, samhsa, west-virginia
Organization: U.S. Department of Health & Human Services
Receiving State or Federal Subsidy 10/1/2000 - 9/30/2001

This report provides state-specific data from fiscal year 2001 about the number of children who are adopted through a public agency and who receive an adoption subsidy.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: adoption, data, fiscal, policy, year
Organization: U.S. Department of Health & Human Services
2014 CMHS Uniform Reporting System (URS) Table for Missouri

2014 Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for Missouri. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: mental-health-services, missouri-mental-health, noms-measures, samhsa, urs-data
Organization: U.S. Department of Health & Human Services
Bone loss: Epidemiology of bone loss

Bone loss occurs when the cellular events of bone formation are quantitatively larger than bone formation. This manuscript discusses the measurement of bone loss, occurrence in the population, risk factors and consequences of bone loss. Recent developments in bone mass measurement and biomarkers have improved our ability to assess bone loss. This process is a normal concomitant of ageing. There are a number of other risk factors, including sex hormone deficiency, physical inactivity, calcium/vitamin D deficiency, inflammatory arthritis, corticosteroids, smoking and alcohol. The major consequence of bone loss in our ageing society is fracture.

Tags: bone-density, bone-loss, fracture-risk, nih, osteoporosis
Organization: U.S. Department of Health & Human Services
Hamster oocyte membrane potential and ion permeability vary with preantral cumulus cell attachment and developmental stage

Background
          In vitro maturation of mammalian oocytes is an area of great interest due to its potential application in the treatment of infertility. The morphological and physiological changes that occur during oocyte development are poorly understood, and further studies are needed investigating the physiological changes associated with oocyte maturation. In this study we evaluated the membrane potential and the sodium/potassium permeability ratio of oocytes acutely isolated, and cumulus-oocyte complexes in metaphase II and preantral follicle stages.
        
        
          Results
          Intracellular electrical recordings revealed that cumulus-enclosed oocytes have a membrane potential significantly more negative at the preantral follicle stage than at metaphase II stage (-38.4 versus -19.7 mV, p < 0.0005). The membrane potential of the cumulus-free oocytes was not different between the preantral and metaphase II stages. The membrane potential of the cumulus cells forming preantral stage follicles was shown to be significantly different from that of the oocyte within the follicle (-28.6 versus -38.4 mV, p < 0.05). The sodium/potassium permeability measured in cumulus-enclosed oocytes at the preantral stage equaled a mean value of 0.33. The ratio was significantly lower when measured in oocytes denuded of cumulus cells or cumulus-enclosed metaphase II oocytes, 0.76, 0.79, 0.77 respectively (p < 0.001).
        
        
          Conclusions
          These data show a change in the membrane potential and Na+/K+ permeability ratio during ooycte development from the preantral stage oocyte to the metaphase II stage. We have also demonstrated a change in the preantral oocyte membrane potential when surrounding cumulus cells are removed; either due to membrane changes or loss of cumulus cells.

Tags: cumulus-cells, ion-permeability, membrane-potential, nih, oocyte-maturation
Organization: U.S. Department of Health & Human Services
Compound 525466: 4,4-Dimethyl-3-thiahexane

Chemical compound data from PubChem database. IUPAC Name: 2-ethylsulfanyl-2-methylbutane. Molecular Formula: C7H16S. Molecular Weight: 132.27. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 525439: 3,6-Dithianonane

Chemical compound data from PubChem database. IUPAC Name: 1-(2-ethylsulfanylethylsulfanyl)propane. Molecular Formula: C7H16S2. Molecular Weight: 164.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Cell adhesion and signaling on the fibronectin 1

Background
          The first type III repeat of fibronectin is known to be involved in fibronectin matrix assembly, and recombinant proteins from this type III repeat can inhibit cell proliferation, tumor metastasis and angiogenesis. We have analyzed the way rat aortic smooth muscle cells (RASMCs) interact with a recombinant protein encompassing a C-terminal portion of the first type III repeat of fibronectin (protein III1-C).
        
        
          Results
          Cells are able to adhere to and spread on III1-C coated on a dish. Both β1 integrins and cell surface heparan sulfate proteoglycans serve as receptors for III1-C. For example, cell attachment to III1-C is partially inhibited by agents that block β1 integrins or by heparin. Complete inhibition of cell attachment is seen only when integrin blocking agents are combined with heparin. Affinity chromatography revealed the binding of proteins that likely represent the integrin β1 and α5 submits to a III1-C column. Cell adhesion to III1-C results in robust ERK1/2 activation that is blocked by integrin-blocking agents. In addition, cell adhesion to III1-C and ERK1/2 activation by III1-C are both inhibited by heparan sulfate but not by chondroitin sulfate. Moreover, heparitinase treatment, but not chondroitinase treatment of RASMCs results in reduced cell adhesion and ERK1/2 activation. Affinity chromatography experiments demonstrated that 35SO4-labeled cell surface heparan sulfate proteoglycans bound specifically to III1-C.
        
        
          Conclusions
          The results suggest that the 1st type III repeat of fibronectin contains a previously unrecognized cell adhesion domain that stimulates robust ERK1/2 activation in RASMCs. Cells interact with this domain through cell surface heparan sulfate proteoglycans and integrins, and both classes of receptors are required for optimal cell adhesion and ERK1/2 activation.

Tags: cell-adhesion, fibronectin-1, integrin-binding, nih, smooth-muscle-cells
Organization: U.S. Department of Health & Human Services
2019-2020 NSDUH State Estimates Of Substance Use And Mental Disorders

State estimates for these years are no longer available due to methodological concerns with combining 2019 and 2020 data. We apologize for any inconvenience or confusion this may causeBecause of the COVID-19 pandemic, most respondents answered the survey via the web in Quarter 4 of 2020, even though all responses in Quarter 1 were from in-person interviews. It is known that people may respond to the survey differently while taking it online, thus introducing what is called a mode effect.When the state estimates were released, it was assumed that the mode effect was similar for different groups of people. However, later analyses have shown that this assumption should not be made. Because of these analyses, along with concerns about the rapid societal changes in 2020, it was determined that averages across the two years could be misleading.For more detail on this decision, see the 2019-2020state data page.

Tags: mental-disorders, samhsa, state-estimates, substance-use, survey-data
Organization: U.S. Department of Health & Human Services
Compound 528391: Tetrachloro-4-hydroxybenzaldehyde

Chemical compound data from PubChem database. IUPAC Name: 2,3,5,6-tetrachloro-4-hydroxybenzaldehyde. Molecular Formula: C7H2Cl4O2. Molecular Weight: 259.9. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services