AndreaBozzo/ceres-open-data-index huggingface dataset:
Genomic approaches to research in lung cancer

The medical research community is experiencing a marked increase in the amount of information available on genomic sequences and genes expressed by humans and other organisms. This information offers great opportunities for improving our understanding of complex diseases such as lung cancer. In particular, we should expect to witness a rapid increase in the rate of discovery of genes involved in lung cancer pathogenesis and we should be able to develop reliable molecular criteria for classifying lung cancers and predicting biological properties of individual tumors. Achieving these goals will require collaboration by scientists with specialized expertise in medicine, molecular biology, and decision-based statistical analysis.

Tags: genomics-research, lung-cancer, molecular-biology, nih, tumor-classification
Organization: U.S. Department of Health & Human Services
Compound 525511: 8-Methyl-4,5-dithia-1-nonene

Chemical compound data from PubChem database. IUPAC Name: 3-methyl-1-(prop-2-enyldisulfanyl)butane. Molecular Formula: C8H16S2. Molecular Weight: 176.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Delta-opioid receptor endocytosis in spinal cord after dermenkephalin activation

Background
          The delta(δ)-opioid receptors belong to the G protein-coupled receptors and in vitro studies have shown that δ-opioid receptors undergo an internalization process in response to agonist stimulation. The immediate consequence is the disappearance of receptors from the plasma membrane. This adaptation process reveals the cell's capacity to desensitize after a strong agonist stimulus. This process, if it occurs in vivo, could contribute to the tolerance phenomenon observed after opiate treatment. To study the mechanisms underlying regulation of the δ-opioid receptors in vivo, the effects of an application of the drug dermenkephalin, a potent and selective agonist of the δ-opioid receptor, were analysed in the rat spinal cord.
        
        
          Results
          Using immunocytochemistry and electron microscopy, we observed in control rats that membrane labelling was strictly localized at the interface between two neurites. Fifteen minutes after dermenkephalin stimulation, the plasma membrane labelling was associated with invaginated areas. Thirty minutes after stimulation, labelled vesicles were found in the cytoplasm confirming the internalization process.
        
        
          Conclusions
          The present findings support the view that δ-opioid receptors are internalized in response to prolonged exposure to dermenkephalin in vivo and confirm the presynaptic localization of δ-opioid receptors in the dorsal horn of the rat spinal cord.

Tags: delta-opioid-receptor, dermenkephalin, nih, receptor-endocytosis, spinal-cord
Organization: U.S. Department of Health & Human Services
Prior Relationship of Adoptive Parent(s) to Child: 10/1/2007 - 9/30/2008

This report provides state-specific data from fiscal year 2008 about the prior relationships of the adoptive parents to the children who were adopted through public agencies.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: adoption, child, data, fiscal, policy
Organization: U.S. Department of Health & Human Services
Annual Report to Congress on State Child Welfare Expenditures reported on the CFS-101 (2016)

This report to Congress provides national totals of planned spending by service category for the Stephanie Tubbs Jones Child Welfare Services program and planned and actual spending by service category for the Promoting Safe and Stable Families program.

For questions on Attachments A and B, please contact Linda Viales at Linda.Viales@acf.hhs.gov for assistance.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: child, policy, reporting, scope, social
Organization: U.S. Department of Health & Human Services
Compound 525165: 2-[2-[2-[2-[2-(2-Acetyloxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethyl acetate

Chemical compound data from PubChem database. IUPAC Name: 2-[2-[2-[2-[2-(2-acetyloxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethyl acetate. Molecular Formula: C16H30O9. Molecular Weight: 366.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2022 Uniform Reporting System (URS) Table For Alaska

This is the 2022 Uniform Reporting System (URS) Output Tables for Alaska. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: alaska-mental-health, block-grant-data, mental-health-services, noms-measures, samhsa
Organization: U.S. Department of Health & Human Services
Extending Medicaid to Young People in Transition from Foster Care

On April 5, 2023, the Children’s Bureau issued Information Memorandum 23-04 on the changes to Medicaid eligibility for youth/young adults age 18 and older who transition out of foster care and move to a new state. On the webinar, the Center for Medicare & Medicaid Services (CMS) will provide an overview to the changes made by the Substance Use-Disorder Prevention that Promotes Opioid Recovery and Treatment for Patients and Communities (SUPPORT) Act and the State Health Official Letter issued by CMS. Following the CMS overview, the Children’s Bureau will provide information on the action steps states can take to collaborate on the implementation.

A critical component of the webinar is to provide information on how the implementation of the SUPPORT Act can be used to address the inequities and health disparities experienced by young people as they transition out of foster care.

Leaders from the Center for Medicare & Medicaid Services (CMS) and the Administration on Children, Youth, and Families (ACYF) presented during the webinar. The webinar was originally recorded on May 11, 2023.

Audio Description Version

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: foster, medicaid, medicare, prevention, substance
Organization: U.S. Department of Health & Human Services
Effect of paper quality on the response rate to a postal survey: A randomised controlled trial. [ISRCTN32032031]

Background
          Response rates to surveys are declining and this threatens the validity and generalisability of their findings. We wanted to determine whether paper quality influences the response rate to postal surveys
        
        
          Methods
          A postal questionnaire was sent to all members of the British Society of Gynaecological Endoscopy (BSGE). Recipients were randomised to receiving the questionnaire printed on standard quality paper or high quality paper.
        
        
          Results
          The response rate for the recipients of high quality paper was 43/195 (22%) and 57/194 (29%) for standard quality paper (relative rate of response 0.75, 95% CI 0.33–1.05, p = 0.1
        
        
          Conclusion
          The use of high quality paper did not increase response rates to a questionnaire survey of gynaecologists affiliated to an endoscopic society.

Tags: gynaecological-endoscopy, nih, paper-quality, postal-survey, survey-response-rate
Organization: U.S. Department of Health & Human Services
Quality end-of-life care: A global perspective

Background
          Quality end-of-life care has emerged as an important concept in industrialized countries.
        
        
          Discussion
          We argue quality end-of-life care should be seen as a global public health and health systems problem. It is a global problem because 85 % of the 56 million deaths worldwide that occur annually are in developing countries. It is a public health problem because of the number of people it affects, directly and indirectly, in terms of the well being of loved ones, and the large-scale, population based nature of some possible interventions. It is a health systems problem because one of its main features is the need for better information on quality end-of-life care. We examine the context of end-of-life care, including the epidemiology of death and cross-cultural considerations. Although there are examples of success, we could not identify systematic data on capacity for delivering quality end-of-life care in developing countries. We also address a possible objection to improving end-of-life care in developing countries; many deaths are preventable and reduction of avoidable deaths should be the focus of attention.
        
        
          Conclusions
          We make three recommendations: (1) reinforce the recasting of quality end-of-life care as a global public health and health systems problem; (2) strengthen capacity to deliver quality end-of-life care; and (3) develop improved strategies to acquire information about the quality of end-of-life care.

Tags: end-of-life-care, global-health, mortality, nih, palliative-care
Organization: U.S. Department of Health & Human Services
21st European Workshop for Rheumatology Research, Vienna, Austria, 1–4 March 2001

Major advances in technology now drive how we approach questions in immunology, particularly in analyzing complex data sets commonly encountered in genomics and proteomics studies. Active areas of investigation include development of novel technologies, identification of elusive target antigens for RA and other diseases, dissection of signaling pathways connecting the lymphocyte cell surface with the nucleus, and exploration of new avenues for therapeutic interventions. The European Workshop for Rheumatology Research (EWRR) is a forum for many European and non-European scientists to present research findings of high quality. Arthritis researchers from around the globe should be strongly encouraged to attend future meetings, the next of which is the 22nd EWRR meeting in Leiden, the Netherlands, in 2002.

Tags: arthritis-research, autoimmune-diseases, ewrr-meeting, nih, rheumatology-research
Organization: U.S. Department of Health & Human Services
Enhanced immunogenicity of a functional enzyme by T cell epitope modification

Background
          T helper epitopes are necessary for the induction of high titers of antigen-specific IgG antibodies. We are interested in the epitope modification of intact proteins as a method to enhance their immunogenicity for the generation of recombinant protein-based vaccines.
        
        
          Results
          Hartley strain guinea pig T cell epitopes were mapped for two related bacterial proteases. Two T cell epitopes were found in one of the proteases, while a comparatively reduced immunogenicity protease had no detectable T cell epitopes. A T cell epitope sequence homologous to the immunogenic protease was created in the less immunogenic protease by changing a single amino acid. Proliferative responses to the whole protein parent enzyme were two-fold higher in splenocyte cultures from variant-immunized animals. We found that the single amino acid change in the variant resulted in a protein immunogen that induced higher titers of antigen-specific IgG antibody at low doses and at early time points during the immunization protocol. The serum from parent- and variant-immunized guinea pigs cross-reacted at both the protein and the peptide level. Finally, animals primed to the variant but boosted with the parent enzyme had higher levels of antigen-specific IgG than animals immunized with the parent enzyme alone.
        
        
          Conclusions
          With a single amino acid change we have introduced a T cell epitope into a comparatively low-immunogenic enzyme and have increased its immunogenicity while retaining the enzyme's original proteolytic function. The ability to immunomodulate proteins while leaving their function intact has important implication for the development of recombinant vaccines and protein-based therapeutics.

Tags: immunogenicity, nih, protein-immunogen, t-cell-epitopes, vaccine-development
Organization: U.S. Department of Health & Human Services
Central effects of clozapine in regulating micturition in anesthetized rats

Background
          We previously showed that systemic administration of the atypical neuroleptic clozapine in the rat altered a number of urodynamic variables and inhibited the external urethral sphincter. Since clozapine acts at several receptor types both at the periphery and the central nervous system, the site of action remained uncertain. Therefore, the purpose of this study was to determine the effects of central administration of clozapine on the bladder and the external urethral sphincter during cystometry and to examine differences in spinal versus supraspinal administration. We extended our observations by delivering clozapine centrally in anesthetized rats instrumented with either an intrathecal (L6-S1 spinal segment) or an intracerebroventricular (lateral ventricle) catheter.
        
        
          Results
          Clozapine decreased micturition volume and increased residual volume possibly by acting at a supraspinal site. Expulsion time and amplitude of the high frequency oscillations were reduced by clozapine possibly by acting at a spinal site. Bladder capacity was increased after central clozapine but probably due to a peripheral effect. Clozapine acting at spinal and supraspinal sites increased pressure threshold. Contraction time and peak pressure were not affected by clozapine. The EMG from the external urethral sphincter was also reduced following clozapine centrally and suggests a spinal and a supraspinal site of action.
        
        
          Conclusions
          The results from the present study suggest that spinal and supraspinal central sites mediate clozapine's action in inhibiting expulsion parameters and the external urethral sphincter of the rat. Therefore, the reduction in the voiding efficiency observed after clozapine appears to be mediated by spinal and supraspinal sites.

Tags: bladder-function, clozapine-effects, micturition-regulation, nih, rat-urodynamics
Organization: U.S. Department of Health & Human Services
2021 Uniform Reporting System (URS) Table For New Hampshire

This is the 2021 Uniform Reporting System (URS) Output Tables for New Hampshire. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-data, mental-health-services, new-hampshire, noms-measures, samhsa
Organization: U.S. Department of Health & Human Services
Compound 525560: N,N-Dimethyl-N'-(3-bromophenyl)-benzamidine

Chemical compound data from PubChem database. IUPAC Name: N'-(3-bromophenyl)-N,N-dimethylbenzenecarboximidamide. Molecular Formula: C15H15BrN2. Molecular Weight: 303.2. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Geographical distribution of publications in the field of medical education

Background
          The geographical distribution of publications as an indicator of the research productivity of individual countries, regions or institutions has become a field of interest. We investigated the geographical distribution of contributions to the two leading journals in the field of medical education, Academic Medicine and Medical Education.
        
        
          Methods
          PubMed was used to search Medline. For both journals all journal articles in each year from 1995 to 2000 were included into the study. Then the affiliation was retrieved from the affiliation field of the MEDLINE format. If this was not possible, it was obtained from the paper version of the journal.
        
        
          Results
          Academic Medicine published contributions from 25 countries between 1995 and 2000. Authors from 50 countries contributed to Medical Education in the same period of time. Authors from the USA and Canada wrote ca. 95% off all articles in Academic Medicine, whereas authors from the UK, Australia, the USA, Canada and the Netherlands were responsible for ca. 74% of all articles in Medical Education in the investigated period of time.
        
        
          Conclusions
          While many countries contributed to both journals, only a few of them were responsible for the majority of all articles.

Tags: geographic-distribution, medical-education, nih, publication-analysis, research-productivity
Organization: U.S. Department of Health & Human Services
Compound 528599: tert-Butyl(dimethyl)silyl myristate

Chemical compound data from PubChem database. IUPAC Name: [tert-butyl(dimethyl)silyl] tetradecanoate. Molecular Formula: C20H42O2Si. Molecular Weight: 342.6. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Using heart-lung interactions to assess fluid responsiveness during mechanical ventilation

According to the Frank-Starling relationship, a patient is a 'responder' to volume expansion only if both ventricles are preload dependent. Mechanical ventilation induces cyclic changes in left ventricular (LV) stroke volume, which are mainly related to the expiratory decrease in LV preload due to the inspiratory decrease in right ventricular (RV) filling and ejection. In the present review, we detail the mechanisms by which mechanical ventilation should result in greater cyclic changes in LV stroke volume when both ventricles are 'preload dependent'. We also address recent clinical data demonstrating that respiratory changes in arterial pulse (or systolic) pressure and in Doppler aortic velocity (as surrogates of respiratory changes in LV stroke volume) can be used to detect biventricular preload dependence, and hence fluid responsiveness in critically ill patients.

Tags: fluid-responsiveness, mechanical-ventilation, nih, preload-dependence, stroke-volume
Organization: U.S. Department of Health & Human Services
4.24 Facility smoking policy, by facility operation and primary focus of facility: 2011 Number and percent distribution

This is a National Survey of Substance Abuse Treatment Services (N-SSATS) data table showing facility smoking policy, by facility operation and primary focus of facility in 2011. N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 States, the District of Columbia, and other U.S. jurisdictions.

Tags: facility-characteristics, n-ssats, samhsa, smoking-policy, substance-abuse-treatment
Organization: U.S. Department of Health & Human Services
Reinforcement of genetic coherence in a two-locus model

Background
          In order to maintain populations as units of reproduction and thus enable anagenetic evolution, genetic factors must exist which prevent continuing reproductive separation or enhance reproductive contact. This evolutionary principle is called genetic coherence and it marks the often ignored counterpart of cladistic evolution. Possibilities of the evolution of genetic coherence are studied with the help of a two-locus model with two alleles at each locus. The locus at which viability selection takes place is also the one that controls the fusion of gametes. The second locus acts on the first by modifying the control of the fusion probabilities. It thus acts as a mating modifier whereas the first locus plays the role of the object of selection and mating. Genetic coherence is enhanced by modifications which confer higher probabilities of fusion to heterotypic gametic combinations (resulting in heterozygous zygotes) at the object locus.
        
        
          Results
          It is shown that mutants at the mating modifier locus, which increase heterotypic fusions but do not lower the homotpyic fusions relative to the resident allele at the object locus, generally replace the resident allele. Since heterozygote advantage at the object locus is a necessary condition for this result to hold true, reinforcement of genetic coherence can be claimed for this case. If the homotypic fusions are lowered, complex situations may arise which may favor or disfavor the mutant depending on initial frequencies and recombination rates. To allow for a generalized analysis including alternative models of genetic coherence as well as the estimation of its degrees in real populations, an operational concept for the measurement of this degree is developed. The resulting index is applied to the interpretation of data from crossing experiments in Alnus species designed to detect incompatibility relations.

Tags: genetic-coherence, mating-modifier, nih, population-genetics, two-locus-model
Organization: U.S. Department of Health & Human Services
2011 CMHS Uniform Reporting System (URS) Output Tables for Northern Mariana Islands

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2011. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, noms-data, northern-mariana-islands, samhsa
Organization: U.S. Department of Health & Human Services
2022 Uniform Reporting System (URS) Table For North Carolina

This is the 2022 Uniform Reporting System (URS) Output Tables for North Carolina. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-data, mental-health-services, noms-measures, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services