AndreaBozzo/ceres-open-data-index huggingface dataset:
Behavioral Health Barometer: Hawaii, 2013

This is a behavioral health report for the state of Hawaii. It uses the  National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment Services (NSSATS) to address the topics of youth substance use , youth mental health and treatment, adult mental health and treatment, substance use, substance use treatment for the years 2008 to 2012.

Tags: adult-mental-health, hawaii-behavioral-health, samhsa, substance-abuse-treatment, youth-substance-use
Organization: U.S. Department of Health & Human Services
Phoenix: Drug-Related Emergency Department Visits, 2004-2011 - Adverse Reactions

Excel file with estimates, rates, relative standard errors, trends and confidence intervals, covering 2004-2011 for emergency department visits involving adverse reactions in the Phoenix metropolitan area. It includes ED visits in which an adverse health consequence (e.g., side effects or an allergic reaction) resulted when taking prescription drugs, over-the-counter medications, or dietary supplements as prescribed or recommended.  This analytic category does not include drug misuse or abuse.File includes data for over 500 drugs, including illicit drugs, prescription and over-the-counter medications, dietary supplements, inhalants and alcohol.  Includes total visits, gender, age group, race/ethnicity, outcome of visit, drug combinations, number of drugs involved in visit, drug frequency, and drugs confirmed by toxicology.Additional detail is provided for illicit drugs, psychotherapeutic drugs, central nervous system (CNS) drugs, respiratory drugs and cardiovascular drugs.

Tags: adverse-drug-reactions, drug-side-effects, emergency-department-visits, prescription-drugs, samhsa
Organization: U.S. Department of Health & Human Services
Respiratory effects of dexmedetomidine in the surgical patient requiring intensive care

The respiratory effects of dexmedetomidine were retrospectively examined in 33 postsurgical patients involved in a randomised, placebo-controlled trial after extubation in the intensive care unit (ICU). Morphine requirements were reduced by over 50% in patients receiving dexmedetomidine. There were no differences in respiratory rates, oxygen saturations, arterial pH and arterial partial carbon dioxide tension (PaCO2) between the groups. Interestingly the arterial partial oxygen tension (PaO2) : fractional inspired oxygen (FIO2) ratios were statistically significantly higher in the dexmedetomidine group. Dexmedetomidine provides important postsurgical analgesia and appears to have no clinically important adverse effects on respiration in the surgical patient who requires intensive care.

Tags: dexmedetomidine-analgesia, icu-patient-outcomes, nih, pao2-fio2-ratio, post-operative-respiratory
Organization: U.S. Department of Health & Human Services
Idaho (ID)

This report presents estimates for measures of substance use and mental health based on the combined 2010 and 2011 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for Idaho for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: idaho, mental-health, samhsa, substance-use, survey-data
Organization: U.S. Department of Health & Human Services
2011 State Profile — Ohio

This is a National Survey of Substance Abuse Treatment Services (N-SSATS) data table showing state profiles for Ohio in 2011. N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 States, the District of Columbia, and other U.S. jurisdictions.

Tags: n-ssats, ohio, samhsa, substance-abuse-treatment, treatment-facilities
Organization: U.S. Department of Health & Human Services
How long should angiotensin-converting enzyme inhibitors be given to patients following myocardial infarction: implications of the HOPE trial

Long-term treatment with angiotensin-converting enzyme inhibitors reduces post-infarction morbidity and mortality in patients with left ventricular (LV) systolic dysfunction or symptomatic heart failure. Until recently, the effect of such treatment in patients with preserved LV function has not been known. The results from the Heart Outcome Prevention Evaluation trial have indicated that long-term treatment with ramipril leads to a significant reduction in cardiovascular events in patients with atherosclerotic disease, including those with prior myocardial infarction and preserved LV function. These results suggest that long-term angiotensin-converting enzyme inhibition should also be considered in post-infarction patients with normal cardiac function.

Tags: ace-inhibitors, cardiovascular-events, heart-outcomes, myocardial-infarction, nih
Organization: U.S. Department of Health & Human Services
Cloning and characterization of the mouse

Background
          Mucolipidosis type IV (MLIV) is an autosomal recessive lysosomal storage disorder characterized by severe neurologic and ophthalmologic abnormalities. Recently the MLIV gene, MCOLN1, has been identified as a new member of the transient receptor potential (TRP) cation channel superfamily. Here we report the cloning and characterization of the mouse homologue, Mcoln1, and report a novel splice variant that is not seen in humans.
        
        
          Results
          The human and mouse genes display a high degree of synteny. Mcoln1 shows 91% amino acid and 86% nucleotide identity to MCOLN1. Also, Mcoln1 maps to chromosome 8 and contains an open reading frame of 580 amino acids, with a transcript length of approximately 2 kb encoded by 14 exons, similar to its human counterpart. The transcript that results from murine specific alternative splicing encodes a 611 amino acid protein that differs at the c-terminus.
        
        
          Conclusions
          Mcoln1 is highly similar to MCOLN1, especially in the transmembrane domains and ion pore region. Also, the late endosomal/lysosomal targeting signal is conserved, supporting the hypothesis that the protein is localized to these vesicle membranes. To date, there are very few reports describing species-specific splice variants. While identification of Mcoln1 is crucial to the development of mouse models for MLIV, the fact that there are two transcripts in mice suggests an additional or alternate function of the gene that may complicate phenotypic assessment.

Tags: lysosomal-storage-disorder, mcoln1-gene, mouse-model, mucolipidosis-type-iv, nih
Organization: U.S. Department of Health & Human Services
Compound 525243: Phthalic acid, propyl nonyl ester

Chemical compound data from PubChem database. IUPAC Name: 2-O-nonyl 1-O-propyl benzene-1,2-dicarboxylate. Molecular Formula: C20H30O4. Molecular Weight: 334.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 525328: 3-Vinyl-1,2-dithiacyclohex-4-ene

Chemical compound data from PubChem database. IUPAC Name: 3-ethenyl-3,6-dihydrodithiine. Molecular Formula: C6H8S2. Molecular Weight: 144.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Enteral feeding in the critically ill: comparison between the supine and prone positions: a prospective crossover study in mechanically ventilated patients

Introduction
          Prone position is effective in mechanically ventilated patients to improve oxygenation. It is unknown if prone position affects gastric emptying and the ability of continued enteral feeding.
        
        
          Aim
          To determine tolerance of enteral feeding by measuring gastric residual volumes in enterally fed patients during supine and prone positions.
        
        
          Methods
          Consecutive mechanically ventilated intensive care patients who were turned to prone position were included. All patients were studied for 6 hours in supine position, immediately followed by 6 hours in prone position, or visa versa. The rate of feeding was unchanged during the study period. Gastric residual volume was measured by suctioning the naso-gastric tube after 3 and 6 hours in the same position. Wilcoxon test and regression analysis were used for analysis.
        
        
          Results
          The median volume of administered enteral feeds was 95 ml after 6 hours in supine position and 110 ml after 6 hours in prone position (P = 0.85). In 10 patients, a greater gastric residual volume was found in prone position. In eight others a greater volume was found in supine position. In 18 of 19 patients, gastric residual volumes in both positions were ≥ 150 ml in 6 hours or ≤ 150 ml in 6 hours. Significantly more sedatives were used in prone position. Regression analysis excluded dopamine dose and the starting position as confounders.
        
        
          Conclusion
          Our results suggest that enteral feeding can be continued when a patient is turned from supine to prone position or vice versa. The results indicate that patients with a clinically significant gastric residual volume in one position are likely to have a clinically significant gastric residual volume in the other position.

Tags: critical-care, enteral-nutrition, gastric-emptying, nih, prone-positioning
Organization: U.S. Department of Health & Human Services
Preconceptional factors associated with very low birthweight delivery in East and West Berlin: a case control study

Background
          Very low birthweight, i.e. a birthweight < 1500 g, is among the strongest determinants of infant mortality and childhood morbidity. To develop primary prevention approaches to VLBW birth and its sequelae, information is needed on the causes of preterm birth, their personal and social antecedents, and on conditions associated with very low birthweight. Despite the growing body of evidence linking sociodemographic variables with preterm delivery, little is known as to how this may be extrapolated to the risk of very low birthweight.
        
        
          Methods
          In 1992, two years after the German unification, we started to recruit two cohorts of very low birthweight infants and controls in East and West Berlin for a long-term neurodevelopmental study. The present analysis was undertaken to compare potential preconceptional risk factors for very low birthweight delivery in a case-control design including 166 mothers (82 East vs. 84 West Berlin) with very low birthweight delivery and 341 control mothers (166 East vs. 175 West).
        
        
          Results
          Multivariate logistic regression analysis was used to assess the effects of various dichotomous parental covariates and their interaction with living in East or West Berlin. After backward variable selection, short maternal school education, maternal unemployment, single-room apartment, smoking, previous preterm delivery, and fetal loss emerged as significant main effect variables, together with living in West Berlin as positive effect modificator for single-mother status.
        
        
          Conclusion
          Very low birthweight has been differentially associated with obstetrical history and indicators of maternal socioeconomic status in East and West Berlin. The ranking of these risk factors is under the influence of the political framework.

Tags: case-control-study, infant-mortality, nih, preconceptional-factors, very-low-birthweight
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Missouri, 2013

This is a behavioral health report for the state of Missouri. It uses the  National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment Services (NSSATS) to address the topics of youth substance use , youth mental health and treatment, adult mental health and treatment, substance use, substance use treatment for the years 2008 to 2012.

Tags: adult-mental-health, missouri-behavioral-health, samhsa, substance-use-treatment, youth-substance-use
Organization: U.S. Department of Health & Human Services
NSDUH 2011 Methodological Resource Book

This Methodological Resource Book (MRB) is intended to serve as documentation of survey materials and methodology associated with the 2011 National Survey on Drug Use and Health (NSDUH). The MRB includes details associated with data collection and processing, such as sampling, instrument testing and development, weighting, imputation, and statistical analyses and inferences.

Tags: data-collection, samhsa, statistical-analysis, substance-use, survey-methodology
Organization: U.S. Department of Health & Human Services
Activation of tumor necrosis factor receptor 1 in airway smooth muscle: a potential pathway that modulates bronchial hyper-responsiveness in asthma?

The cellular and molecular mechanisms that are involved in airway hyper-responsiveness are unclear. Current studies suggest that tumor necrosis factor (TNF)-α, a cytokine that is produced in considerable quantities in asthmatic airways, may potentially be involved in the development of bronchial hyper-responsiveness by directly altering the contractile properties of the airway smooth muscle (ASM). The underlying mechanisms are not known, but growing evidence now suggests that most of the biologic effects of TNF-α on ASM are mediated by the p55 receptor or tumor necrosis factor receptor (TNFR)1. In addition, activation of TNFR1 coupled to the tumor necrosis factor receptor-associated factor (TRAF)2-nuclear factor-κB (NF-κB) pathway alters calcium homeostasis in ASM, which appears to be a new potential mechanism underlying ASM hyper-responsiveness.

Tags: airway-hyperresponsiveness, asthma-research, nih, smooth-muscle-contraction, tnf-alpha
Organization: U.S. Department of Health & Human Services
Transforming growth factor-β1 blocks the enhancement of tumor necrosis factor cytotoxicity by hyaluronidase Hyal-2 in L929 fibroblasts

Background
          Functional antagonism between transforming growth factor beta (TGF-β) and hyaluronidase has been demonstrated. For example, testicular hyaluronidase PH-20 counteracts TGF-β1-mediated growth inhibition of epithelial cells. PH-20 sensitizes various cancer cells to tumor necrosis factor (TNF) cytotoxicity by upregulating proapoptotic p53 and WW domain-containing oxidoreductase (WOX1). TGF-β1 blocks PH-20-increased TNF cytotoxicity. In the present study, the functional antagonism between TGF-β1 and lysosomal hyaluronidases Hyal-1 and Hyal-2 was examined.
        
        
          Results
          Murine L929 fibroblasts were engineered to stably express green-fluorescent protein (GFP)-tagged hyaluronidase (GFP-Hyal-1 or GFP-Hyal-2) or GFP alone. Compared to control cells, Hyal-2-expressing cells had a significantly increased sensitivity to TNF cytotoxicity (~60–110% increase), while Hyal-1-expressing cells were less sensitive to TNF (~20–90% increase). TNF activated NF-κB, along with IκBα degradation, occurred at 20 to 60 min in Hyal-2 cells post stimulation, but at the 20 min time point in both control and Hyal-1 cells. Hyal-2 cells, but not Hyal-1 and control cells, constitutively expressed WOX1, and transiently expressed Hyal-2 enhanced WOX1-mediated cell death. Unlike PH-20, Hyal-1 and Hyal-2 did not induce p53 expression. Hyal-2 translocated from the lysosome to the mitochondria during staurosporine-mediated apoptosis, suggesting that Hyal-2 may damage mitochondria. Finally, Hyal-1 and Hyal-2 blocked TGF-β1-enhanced L929 cell growth. In contrast, TGF-β1 inhibited Hyal-1- and Hyal-2-increased TNF cytotoxicity in L929 cells by 30–50%.
        
        
          Conclusions
          TGF-β1 limits the ability of Hyal-2 to induce TNF cytotoxicity in L929 cells. Hyal-2-increased TNF cytotoxicity in L929 cells appears to be correlated with upregulation of WOX1, a prolonged NF-κB activation, and Hyal-2 translocation to the mitochondria during apoptosis.

Tags: hyaluronidase-hyal-2, l929-fibroblasts, nih, tnf-cytotoxicity, transforming-growth-factor
Organization: U.S. Department of Health & Human Services
PKQuest: a general physiologically based pharmacokinetic model. Introduction and application to propranolol

Background
          A "physiologically based pharmacokinetic" (PBPK) approach uses a realistic model of the animal to describe the pharmacokinetics. Previous PBPKs have been designed for specific solutes, required specification of a large number of parameters and have not been designed for general use.
        
        
          Methods
          This new PBPK program (PKQuest) includes a "Standardhuman" and "Standardrat" data set so that the user input is minimized. It has a simple user interface, graphical output and many new features: 1) An option that uses the measured plasma concentrations to solve for the time course of the gastrointestinal, intramuscular, intraperotineal or skin absorption and systemic availability of a drug – for a general non-linear system. 2) Capillary permeability limitation defined in terms of the permeability-surface area products. 4) Saturable plasma and tissue protein binding. 5) A lung model that includes perfusion-ventilation mismatch. 6) A general optimization routine using either a global (simulated annealing) or local (Powell) minimization applicable to all model parameters.
        
        
          Results
          PKQuest was applied to measurements of human propranolol pharmacokinetics and intestinal absorption. A meal has two effects: 1) increases portal blood flow by 50%; and 2) decreases liver metabolism by 20%. There is a significant delay in the oval propranolol absorption in fasting subjects that is absent in fed subjects. The oral absorption of the long acting form of propranolol continues for a period of more than 24 hours.
        
        
          Conclusions
          PKQuest provides a new general purpose, easy to use, freely distributed  and physiologically rigorous PBPK software routine.

Tags: nih, pbpk-modeling, pharmacokinetics, physiological-modeling, propranolol
Organization: U.S. Department of Health & Human Services
NSDUH 2021 Pair Level Sampling Weight Report

Learn about the techniques used to create weights for the 2021 National Survey on Drug Use and Health (NSDUH) at the pair and questionnaire dwelling unit (QDU) levels. NSDUH is designed so that some of the sampled households have both an adult and a youth respondent who are paired. Because of this, NSDUH allows for estimating characteristics at the person level, pair level, or QDU level. This report describes pair selection probabilities, the generalized exponential model (including predictor variables used), and the multiple weight components that are used for pair or QDU levels of analysis. An evaluation of the calibration weights is also included.Chapters:Introduces the report.Discusses the probability of selection for pairs and QDUs.Briefly describes of the generalized exponential model.Describes the predictor variables for the model calibration.Defines extreme weights.Discusses weight calibrations.Evaluates the calibration weights.Appendices include technical details about the model and the evaluations that were performed.

Tags: nsduh-sampling-weights, pair-level-analysis, qdu-level-analysis, samhsa, substance-use-survey
Organization: U.S. Department of Health & Human Services
Compound 528465: 1-Tridecene, 11-methyl

Chemical compound data from PubChem database. IUPAC Name: 11-methyltridec-1-ene. Molecular Formula: C14H28. Molecular Weight: 196.37. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
B lymphocyte involvement in ankylosing spondylitis: the heavy chain 
variable segment gene repertoire of B lymphocytes from germinal center-like 
foci in the synovial membrane indicates antigen selection

The synovial membrane (SM) of affected joints in ankylosing spondylitis (AS) 
is infiltrated by germinal center-like aggregates (foci) of lymphocytes similar 
to rheumatoid arthritis (RA). We characterized the rearranged heavy chain 
variable segment (VH) genes in the SM for gene usage and the mutational pattern 
to elucidate the B lymphocyte involvement in AS.
        Cryosections from an AS-derived SM were stained for B and T lymphocytes. B 
cells were isolated from different areas of a focus. The rearranged VH genes 
were amplified by semi-nested polymerase chain reaction (PCR) using 
oligonucleotides specific for the six different VH families and heavy chain 
joining segments (JHs). PCR products were cloned and sequenced.
        Fifty-nine of 70 different heavy chain gene rearrangements were potentially 
functional. Most of the rearranged genes were mutated (range, 1–15%). Thirty of 
70 products had a mutational pattern typical for antigen selection. Most of the 
rearranged VH genes belonged to the VH3 family (54%), consistent with data from 
healthy donors and patients with RA, while VH4 genes, in contrast to RA, were 
identified less frequently (10%) and VH5 genes were over-represented (11%). In 
contrast to RA, neither VH6 genes nor the autoimmunity-prone VH4-34 were seen, 
whereas another autoimmunity-prone gene, V3-23, was predominantly used (11%). 
One VH1-derived and one VH3-derived B cell clone were expanded. CDR3 were 
shorter and more variable in length than in RA.
        Comparable with RA and reactive arthritis, there is a biased repertoire of 
selected VH genes, whereas the panel of represented genes is different and less 
clonal expansion was observed.

Tags: ankylosing-spondylitis, b-lymphocytes, nih, synovial-membrane, vh-genes
Organization: U.S. Department of Health & Human Services
Improvement of Drosophila acetylcholinesterase stability by elimination of a free cysteine

Background
          Acetylcholinesterase is irreversibly inhibited by organophosphate and carbamate insecticides allowing its use for residue detection with biosensors. Drosophila acetylcholinesterase is the most sensitive enzyme known and has been improved by in vitro mutagenesis. However, it is not sufficiently stable for extensive utilization. It is a homodimer in which both subunits contain 8 cysteine residues. Six are involved in conserved intramolecular disulfide bridges and one is involved in an interchain disulfide bridge. The 8th cysteine is not conserved and is present at position 290 as a free thiol pointing toward the center of the protein.
        
        
          Results
          The free cysteine has been mutated to valine and the resulting protein has been assayed for stability using various denaturing agents: temperature, urea, acetonitrile, freezing, proteases and spontaneous-denaturation at room temperature. It was found that the C290V mutation rendered the protein 1.1 to 2.7 fold more stable depending on the denaturing agent.
        
        
          Conclusion
          It seems that stabilization resulting from the cysteine to valine mutation originates from a decrease of thiol-disulfide interchanges and from an increase in the hydrophobicity of the buried side chain.

Tags: acetylcholinesterase-stability, drosophila-melanogaster, enzyme-mutagenesis, nih, organophosphate-sensitivity
Organization: U.S. Department of Health & Human Services