AndreaBozzo/ceres-open-data-index huggingface dataset:
Patent AT-E401328-T1: [Translated] BRIDGED N-ARYLSULFONYLPIPERIDINES AS GAMMA SECRETASIS INHIBITORS

Chemical patent from PubChem database. Patent Number: AT-E401328-T1. Title: Combinatorial Chemistry Method. Filing Date: 2008-01-18. Inventors: Chen, Wei, Kumar, Raj, Williams, Sarah. Abstract: A combinatorial chemistry method for generating libraries of chemical compounds is disclosed, enabling rapid identification of lead compounds for drug... IPC Classifications: C08G, C08K, A61K. This patent covers 42 claims related to 5 chemical compounds. Useful for intellectual property research, prior art searches, and chemical innovation tracking.

Tags: chemistry, innovation, patent, pubchem, research
Organization: U.S. Department of Health & Human Services
Northeast: 2011-2012 NSDUH

This report presents the Northeast\'s (e.g., combines Connecticut, Maine, Massachusetts, New Hampshire, New Jersey, New York, Pennsylvania, Rhode Island, and Vermont) estimates for 25 measures of substance use and mental health based on the combined 2009 and 2010 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for the Northeast for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: mental-health, northeast-region, nsduh-survey, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
National Directory of Drug and Alcohol Abuse Treatment Facilities - 1989

The National Directory of Drug and Alcohol Abuse Treatment Programs 1989 lists federal, state, local, and private facilities that provide substance abuse treatment services. The directory includes treatment facilities that are licensed, certified, or otherwise approved for inclusion in the directory by their state substance abuse agencies and that responded to the 1988 National Survey of Substance Abuse Treatment Services (N-SSATS). The information about each facility that appears in this directory was provided by that facility in response to the 1988 N-SSATS. The Substance Abuse and Mental Health Services Administration (SAMHSA) conducts the N-SSATS annually.

Tags: alcohol-abuse-treatment, directory, samhsa, substance-abuse-treatment, treatment-facilities
Organization: U.S. Department of Health & Human Services
Compound 525678: p-Chlorobenzylidene-(3-ethoxyphenyl)-amine

Chemical compound data from PubChem database. IUPAC Name: 1-(4-chlorophenyl)-N-(3-ethoxyphenyl)methanimine. Molecular Formula: C15H14ClNO. Molecular Weight: 259.73. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Synthesis and cytotoxicity of a biotinylated CC-1065 analogue

Background
          The use of pretargeting technology for cancer imaging and treatment has made significant progress in the last few years. This approach takes advantage of the fact that biotin binds strongly to proteins avidin and streptavidin. Thus, a non-toxic tumor cell specific antibody is conjugated with avidin/streptavidin, and is administered to patients. After the antibody binds to tumor cells (usually 24–48 h); a clearing agent is given to remove the residual circulating antibodies in blood. Lastly, a toxic biotin-radioisotope conjugate is administered. Due to the small size of the biotin-radioisotope molecule and tight binding between biotin and avidin/streptavidin, the biotin-radioisotope rapidly binds to tumor cells with high specificity. CC-1065 (1) is one of a few classes of extremely potent antitumor agents, and a biotinalyted CBI-bearing CC-1065 analogue is a promising candidate to be used in the pretargeting technology to treat cancer.
        
        
          Results
          A biotinalyted CBI-bearing CC-1065 analogue, 6, was synthesized. The IC50 of 6 was 0.7 nM against U937 cells. Compound 6 caused apototsis of U937 cells.
        
        
          Conclusions
          For the first time, a biotinalyted CBI-bearing CC-1065 analogue, 6, was synthesized. The biotinylated 6 can serve as a model compound to explore the usefulness of non-radioactive small molecule anticancer drugs in the pretargeting strategy for cancer imaging and therapy.

Tags: biotinylated-cc-1065, cancer-treatment, cytotoxicity, nih, pretargeting-technology
Organization: U.S. Department of Health & Human Services
Compound 529074: 1H-Pyrrole, 1-methyl-2-pentyl

Chemical compound data from PubChem database. IUPAC Name: 1-methyl-2-pentylpyrrole. Molecular Formula: C10H17N. Molecular Weight: 151.25. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Patent AT-E401342-T1: [Translated] METHODS AND MATERIALS FOR DETECTING AND MEASURING DAMAGE CAUSED BY FREE RADICALS

The present invention teaches a marker useful for detection and measurement of free radical damage. Specifically, the invention takes advantage of alterations which occur to the N-terminus of the albumin molecule, a circulating protein in human blood, in the presence of free radicals. These alterations effect the ability of the N-terminus of the albumin molecule to bind metals. Methods for detecting and quantifying this alteration include evaluating and quantifying the cobalt binding capacity of an albumin-containing sample, analysis and measurement of the ability of albumin to bind exogenous cobalt, detection and measurement of the presence of copper in a purified albumin sample and use of an immunological assay specific to the altered form of serum albumin which occurs following free radical damage. Also taught by the present invention is the use of the peptide Asp Ala His Lys and the compound Asp-Ala-His-Lys-R, wherein R is any chemical group capable of producing a detectable signal when a metal ion capable of binding to the N-terminus of naturally-occurring albumin is bound to the compound, for detection and quantitation of the marker. Methods of the present invention also include use of the marker as a "biochemical tag", thereby allowing for sensitive detection and measurement of the efficacy of clinical drugs and therapeutics which result in the generation of free radicals or which act to limit free radical damage. The marker also acts as a "biological tag" of a process implicated in a wide array of diseases and conditions and, accordingly, may be used to monitor and assess such diseases and conditions. Finally, the invention provides antibodies, immunoassays, and kits for use in detecting or quantitating the marker.

Tags: chemistry, innovation, patent, pubchem, research
Organization: U.S. Department of Health & Human Services
2012 State Profile - Florida

This is a National Survey of Substance Abuse Treatment Services (N-SSATS) annual report showing the state profile for Florida in 2012. N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 States, the District of Columbia, and other U.S. jurisdictions.

Tags: florida, n-ssats, samhsa, substance-abuse-treatment, survey
Organization: U.S. Department of Health & Human Services
Patent AT-E400649-T1: [Translated] NEW METHOD FOR INDUCING CELLULAR SENSENCE AND SCREENING METHOD FOR AN ANTI-AGING AGENT

Transformed cells obtained by transferring into normal cells with a gene encoding a protein capable of phosphorylation of p38 protein, or the p38 protein, a variant of the p38 protein, the kinase domain of the p38 protein, the kinase domain of p38 protein variant or a fused protein containing any of them, are new. Independent claims are also included for: (1) screening compounds using normal cells transferred with a gene to induce normal aging cells or cell aging comprising: (a) contacting with a test substance; and (b) analysis of an aging indication in cells; (2) anti-aging agents thus screened; and (3) anti-aging drug compositions containing the screened compounds which are inhibitors of the p38 protein, or a molecule located downstream of p38 in the p38 MAPK pathway or its fused protein. ACTIVITY : Anti-aging. No biological data is given. MECHANISM OF ACTION : None given.

Tags: chemistry, innovation, patent, pubchem, research
Organization: U.S. Department of Health & Human Services
Compound 525494: 5-Methyl-3-thiadecane

Chemical compound data from PubChem database. IUPAC Name: 1-ethylsulfanyl-2-methylheptane. Molecular Formula: C10H22S. Molecular Weight: 174.35. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Patent AT-E401619-T1: [Translated] METHOD FOR INTERFERENCE-FREE IMAGE CAPTURE USING AN ELECTRONIC SENSOR

A method of noise-free image acquisition by means of an electronic sensor, in which an image being detected is continuously contacted more strongly to the sensor, while a sequence of images is received by the means of the sensor. An image is selected from the sequence, according to specified criteria, as an output image (Bt). At least one further image is chosen from the sequence as a correction image (Bs) or is used for determining a correction image and the output image is corrected by subtracting the correction image.

Tags: chemistry, innovation, patent, pubchem, research
Organization: U.S. Department of Health & Human Services
Drug Abuse Warning Network, 2011:  Annual report and reference materials

Includes the annual report with national estimates of drug-related visits to hospital emergency departments (EDs) for 2011, based on data from the Drug Abuse Warning Network (DAWN);  the methodology report, updated for 2011;  a glossary of terms updated for 2011, and a guide to the DAWN trend tables (data tables).

Tags: adverse-drug-events, drug-overdose, emergency-department, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
2016-2017 NSDUH: Guide to State Tables and Summary of SAE Methodology

This document provides information on the model-based small area estimates of substance use and mental disorders in states based on data from the combined 2016-2017 National Surveys on Drug Use and Health (NSDUHs).

Tags: mental-disorders, samhsa, small-area-estimation, state-level-data, substance-use
Organization: U.S. Department of Health & Human Services
2012 Uniform Reporting System (URS) Tables for Virgin Islands

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2012. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, national-outcome-measures, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
Compound 528102: Decyl 3,5-dinitrobenzoate

Chemical compound data from PubChem database. IUPAC Name: decyl 3,5-dinitrobenzoate. Molecular Formula: C17H24N2O6. Molecular Weight: 352.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 528377: 2-Methyl-3-methylenehexane

Chemical compound data from PubChem database. IUPAC Name: 2-methyl-3-methylidenehexane. Molecular Formula: C8H16. Molecular Weight: 112.21. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 64960: 1,5-Anhydroglucitol

Chemical compound data from PubChem database. IUPAC Name: (2R,3S,4R,5S)-2-(hydroxymethyl)oxane-3,4,5-triol. Molecular Formula: C6H12O5. Molecular Weight: 164.16. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 530755: o-Methoxybenzoic acid, 5-fluoro-2-nitrophenyl ester

Chemical compound data from PubChem database. IUPAC Name: (5-fluoro-2-nitrophenyl) 2-methoxybenzoate. Molecular Formula: C14H10FNO5. Molecular Weight: 291.23. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 527987: Octanoic acid, 2-chloro-1-(chloromethyl)ethyl ester

Chemical compound data from PubChem database. IUPAC Name: 1,3-dichloropropan-2-yl octanoate. Molecular Formula: C11H20Cl2O2. Molecular Weight: 255.18. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 525651: N,N-Dimethyl-N'-propyl-p-methoxybenzamidine

Chemical compound data from PubChem database. IUPAC Name: 4-methoxy-N,N-dimethyl-N'-propylbenzenecarboximidamide. Molecular Formula: C13H20N2O. Molecular Weight: 220.31. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Patent AT-E401103-T1: [Translated] DEVICE FOR REGULATING THE FLOW RATE OF AN INTRAVENOUS MEDICAL SOLUTION DURING INJECTION

The object of this invention is to provide a device for regulating the flow rate of an intravenous medical solution during an injection using an intravenous drip unit. The device has a housing ( 10 ) mounted to a hose ( 300 ) to allow the flow of the solution from a solution container ( 200 ) into the vein, and a control member ( 20 ) rotatably assembled with the housing to regulate the flow rate of the solution. The housing has first and second seats ( 11, 12 ) communicating with inlet and outlet ports, and the control member has first and second bosses ( 21, 22 ) seated in the first and second seats. An arc-shaped solution path ( 23 ), a radial channel ( 24 ) and an annular groove ( 25 ) are formed on the control member to regulate the flow rate of the solution in accordance with an adjusted angle of the control member relative to the fixed housing.

Tags: chemistry, innovation, patent, pubchem, research
Organization: U.S. Department of Health & Human Services
Patent AT-E401174-T1: [Translated] RAZOR BLADE UNIT OF A SAFETY RAZOR

Chemical patent from PubChem database. Patent Number: AT-E401174-T1. Title: Process for Preparing Therapeutic Agents. Filing Date: 1992-01-26. Inventors: Smith, John A., Johnson, Mary B.. Abstract: A process for preparing therapeutic agents is described, involving multiple synthetic steps with optimized reaction conditions. The process enables la... IPC Classifications: C07C, C07B, A61K. This patent covers 33 claims related to 4 chemical compounds. Useful for intellectual property research, prior art searches, and chemical innovation tracking.

Tags: chemistry, innovation, patent, pubchem, research
Organization: U.S. Department of Health & Human Services
Blood borne transit of CJD from brain to gut at early stages of infection

Background
          In Creutzfeldt-Jakob disease (CJD) and other related transmissible spongiform encephalopathies it is critical to understand the various pathways by which the infectious agent spreads to different organs.
        
        
          Methods
          We injected a CJD agent into mice, either intracerebrally (ic) or intraperitoneally (ip) and monitored the progressive appearance of abnormal PrP in peripheral tissues over time.
        
        
          Results
          Abnormal PrP was detected in lymphoreticular tissues of the gastrointestinal tract as early as 28 to 32 days after infection by both routes. This change persisted until the terminal stages of disease. In contrast, abnormal PrP was not detected in brain or spinal cord until 80 to 120 days after ic inoculation, or until 170 days after ip inoculation.
        
        
          Conclusions
          Brain lacks significant lymphatic drainage, and has little infectivity before 40 days, even after ic inoculation. Thus the infectious inoculum must spread to the gut by a vascular route, a direction opposite to that generally assumed. This interpretation is consistent with previous studies demonstrating white blood cell infectivity as well as perivascular PrP accumulations in CJD. Notably, enteric infection at early as well as later stages of disease, and regardless of the route of agent entry, implicates potential environmental spread by fecal matter.

Tags: creutzfeldt-jakob-disease, infectious-disease-transmission, mouse-model, nih, prion-disease
Organization: U.S. Department of Health & Human Services
2015 CMHS Uniform Reporting System (URS) Table for New Hampshire

2015 Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for New Hampshire.  The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, national-outcome-measures, samhsa, urs-data
Organization: U.S. Department of Health & Human Services
Compound 525355: 2,2-Dimethyl-4,5-dithiaoctane

Chemical compound data from PubChem database. IUPAC Name: 2,2-dimethyl-1-(propyldisulfanyl)propane. Molecular Formula: C8H18S2. Molecular Weight: 178.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Patent AT-E399517-T1: [Translated] VALVE WITH A CIRCULATION CHANNEL, WITH A PROFILED MOUNTING BALLOON AND WITH A DEVICE FOR BLOCKING OFF A FLOW

A urethral valve system includes a fixation balloon that is positioned in and contoured to the geometry of the bladder near the opening to the urethra. The fixation balloon, which is narrower at an end that is closest to the urethra and wider at an opposite end, includes a channel through which urine is directed to flow from the bladder to the urethra. A valve balloon is positioned in the channel and inflates to prevent urine flow through the channel and deflates to allow urine to flow around the balloon and out the end of the channel. The fixation balloon may be attached to a Foley-type catheter, with the catheter providing the channel through the balloon. The fixation balloon then acts as a shock absorber for the system by moving relative to the catheter in response to, for example, a contraction in the bladder. The catheter may contain lumens that provide access to the valve balloon and/or the fixation balloon. The fixation balloon is inserted in a deflated state and inflated to hold the system in place. The fixation balloon remains inflated with the valve balloon providing continence when it is in an inflated state and allowing voiding when it is in a deflated state. Only when the device is to be removed from the body is the fixation balloon deflated.

Tags: chemistry, innovation, patent, pubchem, research
Organization: U.S. Department of Health & Human Services
Compound 528293: Benzene, 1,2,5-trimethyl-3-propyl

Chemical compound data from PubChem database. IUPAC Name: 1,2,5-trimethyl-3-propylbenzene. Molecular Formula: C12H18. Molecular Weight: 162.27. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Sequence requirements for RNA strand transfer during nidovirus discontinuous subgenomic RNA synthesis

Nidovirus subgenomic mRNAs contain a leader sequence derived from the 5′ end of the genome fused to different sequences (‘bodies’) derived from the 3′ end. Their generation involves a unique mechanism of discontinuous subgenomic RNA synthesis that resembles copy-choice RNA recombination. During this process, the nascent RNA strand is transferred from one site in the template to another, during either plus or minus strand synthesis, to yield subgenomic RNA molecules. Central to this process are transcription-regulating sequences (TRSs), which are present at both template sites and ensure the fidelity of strand transfer. Here we present results of a comprehensive co-variation mutagenesis study of equine arteritis virus TRSs, demonstrating that discontinuous RNA synthesis depends not only on base pairing between sense leader TRS and antisense body TRS, but also on the primary sequence of the body TRS. While the leader TRS merely plays a targeting role for strand transfer, the body TRS fulfils multiple functions. The sequences of mRNA leader–body junctions of TRS mutants strongly suggested that the discontinuous step occurs during minus strand synthesis.

Tags: nidovirus-synthesis, nih, rna-strand-transfer, subgenomic-rna, trs-sequences
Organization: U.S. Department of Health & Human Services