AndreaBozzo/ceres-open-data-index huggingface dataset:
Physicians' preference values for hepatitis C health states and antiviral therapy: A survey

Background
          Physicians' perspectives regarding hepatitis C shape their approach to patient management. We used utility analysis to evaluate physicians' perceptions of hepatitis C-related health states (HS) and their threshold to recommend treatment.
        
        
          Methods
          A written questionnaire was administered to practicing physicians. They were asked to rate hepatitis C health states on a visual analog scale ranging from 0% (death) to 100% (health without hepatitis C). Physicians then judged quality of life associated with the side effects of antiviral therapy for hepatitis C and indicated the sustained virological response rate that they would require to recommend treatment.
        
        
          Results
          One hundred and thirteen physicians from five states were included. Median utility ratings for hepatitis C health states declined significantly with increasing severity of symptoms: HS1-No Symptoms, No Cirrhosis (88%; 12% reduction from good health), HS2-Mild Symptoms, No Cirrhosis (66%), HS3-Moderate Symptoms, No Cirrhosis (49%), HS4-Mild Symptoms, Cirrhosis (40%), HS5-Severe Symptoms, Cirrhosis (18%) [p < 0.001]. The median rating for life with side effects of antiviral therapy was 47%, suggesting a 53% reduction from good health. That was similar to the utility value for HS3-Moderate Symptoms, No Cirrhosis. The median threshold value for recommending treatment was a sustained response rate of 60%.
        
        
          Conclusions
          1) Physicians' utility ratings for hepatitis C health states were inversely related to the severity of disease manifestations described. 2) Physicians viewed side effects of therapy unfavorably and indicated that on average, they would require a 60% sustained response rate before recommending treatment, which far exceeds the efficacy of current antiviral therapy for hepatitis C in the majority of patients.

Tags: antiviral-therapy, health-state-utilities, hepatitis-c, nih, physician-preferences
Organization: U.S. Department of Health & Human Services
Table 7. 2011-2012 NSDUH Cocaine Use in the Past Year, by Age Group and State

Table 7. Cocaine Use in the Past Year, by Age Group and State: Percentages, Annual Averages Based on 2011 and 2012 NSDUHs. Results are provided by State and for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: age-groups, cocaine-use, samhsa, state-level-data, substance-abuse
Organization: U.S. Department of Health & Human Services
Gender-related plasma levels of progesterone, interleukin-8 and interleukin-10 during and after cardiopulmonary bypass in infants and children

Background
          It is known that proinflammatory and anti-inflammatory cytokines are released during and after cardiopulmonary bypass (CPB) in infants and children. Sex steroids are known to have immunomodulatory functions, and release of the anti-inflammatory cytokine IL-10 is stimulated by progesterone in vitro. The purpose of the present study was to investigate the plasma levels of progesterone, IL-8 (proinflammatory cytokine) and IL-10, and to relate them to sex and postoperative morbidity.
        
        
          Method
          Eighteen infants and children (eight female) undergoing CPB were prospectively studied. Plasma levels of progesterone, IL-8 and IL-10 were determined before and 10 min after the start of CPB, and immediately after CPB; and 6 h, 24 h, 3 days and 7 days postoperatively. Organ dysfunction was identified on the basis of arbitrarily defined criteria.
        
        
          Results
          After CPB, all patients showed significant increases in plasma levels of progesterone, IL-8 and IL-10. Plasma levels of IL-10 were significantly higher in female patients, except for during the immediate postoperative period. According to the criteria used, six out of 10 male patients, but none of the female patients developed multiple organ dysfunction (MOD).
        
        
          Conclusion
          The present study shows that CPB induces a significant and marked increase in plasma levels of progesterone in infants and children. Studies of administration of progesterone-blocking substances to male and female animals may help to elucidate the roles of sex and progesterone in the setting of CBP.

Tags: cardiopulmonary-bypass, cytokine-levels, nih, pediatric-cardiology, progesterone-levels
Organization: U.S. Department of Health & Human Services
Alaska (AK)

This report presents Alaska\'s estimates for 25 measures of substance use and mental health based on the combined 2009 and 2010 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for Alaska for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: alaska-health, mental-health, nsduh-data, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Publications Using SAMHSA DataPortland-Vancouver-Hillsboro, OR-WA

This report presents combined 2005 to 2010 National Survey on Drug Use and Health (NSDUH) results for those aged 12 or older in the Portland-Vancouver-Hillsboro, OR-WA metro area. The report includes estimates of substance use disorder, major depressive episode, illicit drug use, marijuana use, cigarette use, binge alcohol use, and the nonmedical use of prescription-type pain relievers. Results are provided for the Pitts Portland-Vancouver-Hillsboro metro area, Oregon, and the U.S. overall.

Tags: major-depressive-episode, nsduh-data, samhsa, substance-use-disorder, survey
Organization: U.S. Department of Health & Human Services
Human cytomegalovirus IE1 promoter/enhancer drives variable gene expression in all fiber types in transgenic mouse skeletal muscle

Background
          Versatile transgenic manipulation of skeletal muscle requires knowledge of the expression profiles of diverse promoter/enhancer elements in the transcriptionally specialized fiber types of which muscle is composed. "Universal" viral promoters/enhancers, e.g., cytomegalovirus IE1 (CMV IE1), are of interest as reagents that may drive broad expression. However, a previous study noted a marked heterogeneity of CMV IE1-driven transgene expression among muscle fibers, raising the possibility of fiber-type-restricted expression. The purpose of the present study was to characterize CMV IE1-driven expression in terms of fiber type.
        
        
          Results
          We produced two lines of transgenic mice carrying the CMV IE1/ β-galactosidase construct CMVLacZ, and analyzed transgene expression and fiber type by histochemical analysis of hindlimb muscle sections. In both lines CMVLacZ was expressed in all four major fiber types: type I (slow) and types IIA, IIB and IIX (fast). There was no unique pattern of fiber-type-preferential expression; fiber-type quantitative differences were observed but details varied between muscle regions and between lines. Both lines showed similar fiber-type-independent regional differences in overall expression levels, and a high level of within-fiber-type variability of expression, even among nearby fibers. The soleus muscle showed strong expression and comparatively little within-fiber-type or between-fiber-type variability.
        
        
          Conclusions
          The CMV IE1 promoter/enhancer is not fiber-type-restricted and can be useful for driving germ-line transgene expression in all four fiber types. However, not all fibers express the gene at high levels due in part to regional differences in overall expression levels, and to a high level of within-fiber-type variability. Given the multinucleate syncitial nature of muscle fibers, it is not likely that this variability is due to variegating heterochromatinization. The soleus muscle would make a suitable subject for near-uniform experimental gene expression driven by CMV IE1 elements.

Tags: cytomegalovirus-ie1, gene-expression, nih, skeletal-muscle, transgenic-mice
Organization: U.S. Department of Health & Human Services
2020 Uniform Reporting System (URS) Table For Louisiana

This is the 2020 Uniform Reporting System (URS) Output Tables for Louisiana. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-program, mental-health-services, national-outcome-measures, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
2017-2018 NSDUH: P-Value Tables For Geographic Comparison

Compare state-level estimates from the 2017-2018 National Surveys on Drug Use and Health (NSDUH) using p-values. The tables accompany the2017-2018 NSDUH State Estimates of Substance Use and Mental Disorders, and can be used to determine whether the difference in estimates between two geographic areas are statistically significant. A guide to their use is also included.The tables are available in an Excel spreadsheet or a zip file containing CSV text files. Each tab or text file contains p-values for a particular measure and a particular age group.

Tags: mental-disorders, samhsa, state-estimates, statistical-significance, substance-use
Organization: U.S. Department of Health & Human Services
2008-2010 NSDUH Substate Region Definitions

This report discusses the substate region definitions and maps used in the 2008 to 2010 National Survey on Drug Use and Health (NSDUH) report that assesses past year alcohol use disorder and illicit drug use disorder among persons aged 12 or older by 362 substate regions within the 50 States and the District of Columbia.

Tags: alcohol-use-disorder, drug-use-disorder, nsduh, samhsa, substate-regions
Organization: U.S. Department of Health & Human Services
Inhaled nitric oxide in persistent pulmonary hypertension of the
		  newborn refractory to high-frequency ventilation

Background:
          This study was designed to evaluate the effect of nitric oxide
				(NO) on the management of neonates with severe persistent pulmonary
				hypertension refractory to high-frequency oscillatory ventilation.
        
        
          Methods:
          The birth weight and the gestational age of infants
				were 3125.5 ± 794 g (mean ± SD) and 39 ± 2.4 weeks, respectively. All
				neonates were ventilated for an average of 137.5 min (range 90-180 min) prior to
				NO therapy. The mean oxygenation index (OI) of all neonates prior to NO was
				46.3 ± 5 (mean ± SEM). NO was initially administered at 20 parts per
				million (ppm) for at least 2 h and increased gradually by 2 ppm to a maximum of
				80 ppm.
        
        
          Results:
          Eighteen infants (75%) responded and six (25%) did not respond to
				the treatment. Three neonates died in the responding group, while all the
				non-responders died (P = 0.0001). The survival rate was 62.5% among all
				neonates. NO significantly decreased OI (P < 0.0001) and improved
				the arterial/alveolar (a/A) oxygen ratio (P < 0.0001) within the
				first 2 h of NO therapy in 61.1% of the responders. However, the OI and the a/A
				oxygen ratio remained almost the same throughout the treatment in the
				non-responders and the non-survivors.
        
        
          Conclusion:
          Inhaled NO at 20 ppm, following adequate ventilation for 2 h without
				significant response, could be used to identify the majority of the
				non-responders in order to seek other alternatives.

Tags: inhaled-nitric-oxide, neonatal-outcomes, nih, oxygenation-index, pulmonary-hypertension
Organization: U.S. Department of Health & Human Services
Platelet glycoprotein IIb/IIIa receptor blockade in coronary artery disease

Glycoprotein IIb/IIIa inhibitors represent a new promising class of antiplatelet medications. Their use in acute coronary syndromes and for patients undergoing percutaneous coronary intervention has been the subject of a number of large controlled trials using both the intravenous and the oral forms. In this review, we present a systematic overview of these trials.

Tags: antiplatelet-therapy, coronary-artery-disease, glycoprotein-inhibitors, nih, percutaneous-intervention
Organization: U.S. Department of Health & Human Services
Inhaled nitric oxide in acute respiratory distress syndrome with and without septic shock requiring norepinephrine administration: a dose–response study

Background:
          The aim of this prospective study was to assess whether the presence of septic shock could influence the dose response to inhaled nitric oxide (NO) in NO-responding patients with adult respiratory distress syndrome (ARDS).
        
        
          Results:
          Eight patients with ARDS and without septic shock (PaO2 = 95 ± 16 mmHg, PEEP = 0, FiO2 = 1.0), and eight patients with ARDS and septic shock (PaO2 = 88 ± 11 mmHg, PEEP = 0, FiO2 = 1.0) receiving exclusively norepinephrine were studied. All responded to 15 ppm inhaled NO with an increase in PaO2 of at least 40 mmHg, at FiO2 1.0 and PEEP 10 cmH2O. Inspiratory intratracheal NO concentrations were recorded continuously using a fast response time chemiluminescence apparatus. Seven inspiratory NO concentrations were randomly administered: 0.15, 0.45, 1.5, 4.5, 15, 45 and 150 ppm. In both groups, NO induced a dose-dependent decrease in mean pulmonary artery pressure (MPAP), pulmonary vascular resistance index (PVRI), and venous admixture (QVA/QT), and a dose-dependent increase in PaO2/FiO2 (P ≤ 0.012). Dose-response of MPAP and PVRI were similar in both groups with a plateau effect at 4.5 ppm. Dose-response of PaO2/FiO2 was influenced by the presence of septic shock. No plateau effect was observed in patients with septic shock and PaO2/FiO2 increased by 173 ± 37% at 150 ppm. In patients without septic shock, an 82 ± 26% increase in PaO2/FiO2 was observed with a plateau effect obtained at 15 ppm. In both groups, dose-response curves demonstrated a marked interindividual variability and in five patients pulmonary vascular effect and improvement in arterial oxygenation were dissociated.
        
        
          Conclusion:
          For similar NOinduced decreases in MPAP and PVRI in both groups, the increase in arterial oxygenation was more marked in patients with septic shock.

Tags: ards-septic-shock, dose-response-study, inhaled-nitric-oxide, nih, pulmonary-hypertension
Organization: U.S. Department of Health & Human Services
Stable hepatitis C virus RNA detection by RT-PCR during four days storage

Background
          Suboptimal specimen processing and storage conditions of samples which contain hepatitis C virus (HCV) RNA may result in a decline of HCV RNA concentration or false-negative results in the detection of HCV RNA in serum. We evaluated the stability of HCV RNA in serum and clotted blood samples stored at room temperature or at 4°C for 4 days with the aim of optimizing the standard procedures of processing and storage of samples.
        
        
          Methods
          Blood from five HCV RNA positive patients was collected in tubes with and without separator gel, centrifuged 1 or 6 hours after collection. Samples were then left 6, 24, 48, 72 or 96 h at room temperature (21.5 – 25.4°C) or at 4°C before determining their HCV RNA level using the COBAS AMPLICOR HCV MONITOR Test, vs 2.0 (Roche Diagnostic Systems).
        
        
          Results
          The logarithm of the HCV RNA level measurements remained within a 0.3 value of the means for 4 days at both temperatures (room temperature or 4°C).
        
        
          Conclusions
          We conclude that blood samples may be collected and aliquoted within 6 h of collection and can be stored at 4°C for 72 hours as proposed by the manufacturer without significant differences in measured HCV RNA level. Our results indicate that lapses in this scheme may still yield reliable results.

Tags: hepatitis-c, nih, rna-stability, rt-pcr, specimen-storage
Organization: U.S. Department of Health & Human Services
2010 CMHS Uniform Reporting System (URS) Output Tables for Michigan

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2010. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, national-outcome-measures, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
Cloning and expression of the rabbit prostaglandin EP2 receptor

Background
          Prostaglandin E2 (PGE2) has multiple physiologic roles mediated by G protein coupled receptors designated E-prostanoid, or "EP" receptors. Evidence supports an important role for the EP2 receptor in regulating fertility, vascular tone and renal function.
        
        
          Results
          The full-length rabbit EP2 receptor cDNA was cloned. The encoded polypeptide contains 361 amino acid residues with seven hydrophobic domains. COS-1 cells expressing the cloned rabbit EP2 exhibited specific [3H]PGE2 binding with a Kd of 19.1± 1.7 nM. [3H]PGE2 was displaced by unlabeled ligands in the following order: PGE2>>PGD2=PGF2α=iloprost. Binding of [3H]PGE2 was also displaced by EP receptor subtype selective agonists with a rank order of affinity consistent with the EP2 receptor (butaprost>AH13205>misoprostol>sulprostone). Butaprost free acid produced a concentration-dependent increase in cAMP accumulation in rabbit EP2 transfected COS-1 cells with a half-maximal effective concentration of 480 nM. RNase protection assay revealed high expression in the ileum, spleen, and liver with lower expression in the kidney, lung, heart, uterus, adrenal gland and skeletal muscle. In situ hybridization localized EP2 mRNA to the uterine endometrium, but showed no distinct localization in the kidney. EP2 mRNA expression along the nephron was determined by RT-PCR and its expression was present in glomeruli, MCD, tDL and CCD. In cultured cells EP2 receptor was not detected in collecting ducts but was detected in renal interstitial cells and vascular smooth muscle cells. EP2 mRNA was also detected in arteries, veins, and preglomerular vessels of the kidney.
        
        
          Conclusion
          EP2 expression pattern is consistent with the known functional roles for cAMP coupled PGE2 effects in reproductive and vascular tissues and renal interstitial cells. It remains uncertain whether it is also expressed in renal tubules.

Tags: e-prostanoid-receptor, nih, prostaglandin-ep2-receptor, rabbit-model, receptor-cloning
Organization: U.S. Department of Health & Human Services
Telomere formation on macronuclear chromosomes of

Background
          Ciliates employ massive chromatid breakage and de novo telomere formation during generation of the somatic macronucleus. Positions flanking the 81-MAC locus are reproducibly cut. But those flanking the Common Region are proposed to often escape cutting, generating three nested macronuclear chromosomes, two retaining "arms" still appended to the Common Region. Arm-distal positions must differ (in cis) from the Common Region flanks.
        
        
          Results
          The Common-Region-flanking positions also differ from the arm-distal positions in that they are "multi-TAS" regions: anchored PCR shows heterogeneous patterns of telomere addition sites, but arm-distal sites do not. The multi-TAS patterns are reproducible, but are sensitive to the sequence of the allele being processed. Thus, random degradation following chromatid cutting does not create this heterogeneity; these telomere addition sites also must be dictated by cis-acting sequences.
        
        
          Conclusions
          Most ciliates show such micro-heterogeneity in the precise positions of telomere addition sites. Telomerase is believed to be tightly associated with, and act in concert with, the chromatid-cutting nuclease: heterogeneity must be the result of intervening erosion activity. Our "weak-sites" hypothesis explains the correlation between alternative chromatid cutting at the Common Region boundaries and their multi-TAS character: when the chromatid-breakage machine encounters either a weak binding site or a weak cut site at these regions, then telomerase dissociates prematurely, leaving the new end subject to erosion by an exonuclease, which pauses at cis-acting sequences; telomerase eventually heals these resected termini. Finally, we observe TAS positioning influenced by trans-allelic interactions, reminiscent of transvection.

Tags: chromatid-breakage, ciliates, macronuclear-chromosomes, nih, telomere-formation
Organization: U.S. Department of Health & Human Services
NOAA/WDS Paleoclimatology - Manzanedo - Leipzig - FASY - ITRDB GERM225

This archived Paleoclimatology Study is available from the NOAA National Centers for Environmental Information (NCEI), under the World Data Service (WDS) for Paleoclimatology. The associated NCEI study type is Tree Ring. The data include parameters of tree ring with a geographic location of Germany, Western Europe. The time period coverage is from 142 to -63 in calendar years before present (BP). See metadata information for parameter and study location details. Please cite this study when using the data.

Tags: biological records, climate indicators, common beech, continent, doc/noaa/nesdis/ncei, earth science, europe, european beech, fagus sylvatica l., fasy, germany, land records, latitude 51.43, leipzig, longitude 12.79, material: null, national centers for environmental information, nesdis, noaa, paleoclimate, paleoclimate indicators, tree ring, tree rings, tree-ring, u.s. department of commerce, western europe, what: age, what: total ring width, width
Organization: National Oceanic and Atmospheric Administration, Department of Commerce
NOAA/WDS Paleoclimatology - Rahman - Lawachara National Park - CKTA - ITRDB BGD001

This archived Paleoclimatology Study is available from the NOAA National Centers for Environmental Information (NCEI), under the World Data Service (WDS) for Paleoclimatology. The associated NCEI study type is Tree Ring. The data include parameters of tree ring with a geographic location of Bangladesh, Southcentral Asia. The time period coverage is from 39 to -62 in calendar years before present (BP). See metadata information for parameter and study location details. Please cite this study when using the data.

Tags: asia, bangladesh, biological records, burma almondwood, chickrassy, chittagong wood, chukrasia tabularis a.juss., ckta, climate indicators, continent, doc/noaa/nesdis/ncei, earth science, land records, latitude 24.342309, lawachara national park, longitude 91.798301, material: null, national centers for environmental information, nesdis, noaa, paleoclimate, paleoclimate indicators, southcentral asia, tree ring, tree rings, tree-ring, u.s. department of commerce, what: age, what: total ring width, width
Organization: National Oceanic and Atmospheric Administration, Department of Commerce