AndreaBozzo/ceres-open-data-index huggingface dataset:
Experimental arthritis induced by a clinical

Background
          Mycoplasma fermentans has been associated with rheumatoid arthritis. Recently, it was detected in the joints and blood of patients with rheumatoid arthritis, but it is not clear yet how the bacteria enter the body and reach the joints. The purpose of this study was to determine the ability of M. fermentans to induce experimental arthritis in rabbits following inoculation of the bacteria in the trachea and knee joints.
        
        
          Methods
          P-140 and PG-18 strains were each injected in the knee joints of 14 rabbits in order to evaluate and compare their arthritogenicity. P-140 was also injected in the trachea of 14 rabbits in order to test the ability of the bacteria to reach the joints and induce arthritis.
        
        
          Results
          M. fermentans produced an acute arthritis in rabbits. Joint swelling appeared first in rabbits injected with P-140, which caused a more severe arthritis than PG-18. Both strains were able to migrate to the uninoculated knee joints and they were detected viable in the joints all along the duration of the experiment. Changes in the synovial tissue were more severe by the end of the experiment and characterized by the infiltration of neutrophils and substitution of adipose tissue by connective tissue. Rabbits intracheally injected with P-140 showed induced arthritis and the bacteria could be isolated from lungs, blood, heart, kidney, spleen, brain and joints.
        
        
          Conclusion
          M. fermentans induced arthritis regardless of the inoculation route. These findings may help explain why mycoplasmas are commonly isolated from the joints of rheumatic patients.

Tags: experimental-arthritis, mycoplasma-fermentans, nih, rabbit-model, rheumatoid-arthritis
Organization: U.S. Department of Health & Human Services
Compound 525378: 2,4-Dithiaoctane

Chemical compound data from PubChem database. IUPAC Name: 1-(methylsulfanylmethylsulfanyl)butane. Molecular Formula: C6H14S2. Molecular Weight: 150.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Reconstitution of licensed replication origins on

Background
          In order to ensure precise chromosome duplication, eukaryotes "license" their replication origins during late mitosis and early G1 by assembling complexes of Mcm2-7 onto them. Mcm2-7 are essential for DNA replication, but are displaced from origins as they initiate, thus ensuring that no origin fires more than once in a single cell cycle.
        
        
          Results
          Here we show that a combination of purified nucleoplasmin, the origin recognition complex (ORC), Cdc6, RLF-B/Cdt1 and Mcm2-7 can promote functional origin licensing and the assembly of Mcm2-7 onto Xenopus sperm nuclei. The reconstituted reaction is inhibited by geminin, a specific RLF-B/Cdt1 inhibitor. Interestingly, the purified ORC used in the reconstitution had apparently lost the Orc6 subunit, suggesting that Orc6 is not essential for replication licensing. We use the reconstituted system to make a preliminary analysis of the different events occuring during origin assembly, and examine their nucleotide requirements. We show that the loading of Xenopus ORC onto chromatin is strongly stimulated by both ADP, ATP and ATP-γ-S whilst the loading of Cdc6 and Cdt1 is stimulated only by ATP or ATP-γ-S.
        
        
          Conclusions
          Nucleoplasmin, ORC, Cdc6, RLF-B/Cdt1 and Mcm2-7 are the only proteins required for functional licensing and the loading of Mcm2-7 onto chromatin. The requirement for nucleoplasmin probably only reflects a requirement to decondense sperm chromatin before ORC can bind to it. Use of this reconstituted system should allow a full biochemical analysis of origin licensing and Mcm2-7 loading.

Tags: dna-replication, mcm2-7, nih, origin-licensing, replication-origins
Organization: U.S. Department of Health & Human Services
Research Article: Current Controlled Trials in Cardiovascular Medicine

Some problems with the quality of controlled clinical trials can be addressed by following these procedures: registering all trials at inception; using systematic reviews to inform the design of new studies; posting and obtaining feedback on preprints; reporting all well conducted trials, regardless of their results; reducing biased and inefficient assessment of reports submitted for publication; publishing sufficiently detailed reports; linking trial reports to relevant external information; providing readier access to reports; and reviewing and amending reports after initial publication. The launch of a new range of electronic journals by Current Controlled Trials offers an opportunity to contribute to progress in these ways.

Tags: cardiovascular-trials, clinical-trial-quality, nih, publication-bias, trial-registration
Organization: U.S. Department of Health & Human Services
Connecticut (CT)

This report presents estimates for measures of substance use and mental health based on the combined 2010 and 2011 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for Connecticut for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: ct-survey, mental-health, nsduh-data, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Arkansas (AR)

This report presents estimates for measures of substance use and mental health based on the combined 2010 and 2011 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for Arkansas for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: arkansas-health, mental-health, nsduh-data, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
2012 Uniform Reporting System (URS) Tables for New Mexico

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2012. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: behavioral-health-urs, community-mental-health, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
South (S)

This report presents the South\'s (e.g., combines Alabama, Arkansas, Delaware, District of Columbia, Florida, Georgia, Kentucky, Louisiana, Maryland, Mississippi, North Carolina, Oklahoma, South Carolina, Tennessee, Texas, Virginia, and West Virginia) estimates for 25 measures of substance use and mental health based on the combined 2009 and 2010 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for the South for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: mental-health, national-survey, samhsa, south-region, substance-use
Organization: U.S. Department of Health & Human Services
Availability of Fiscal Year (FY) 2022 Children's Justice Act Grants to States Under the Child Abuse Prevention and Treatment Act (CAPTA)

This Program Instruction (PI) provides guidance on the eligibility requirements and the grant application procedures for FY 2022 Children’s Justice Act (CJA) grants and to provide the tentative State allocation table.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: abuse, fiscal, grant, instruction, prevention
Organization: U.S. Department of Health & Human Services
2022 Uniform Reporting System (URS) Table For Florida

This is the 2022 Uniform Reporting System (URS) Output Tables for Florida. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: florida-mental-health, mental-health-services, outcome-measures, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
Washington: 2011-2012 NSDUH

This report presents Washington\'s estimates for 25 measures of substance use and mental health based on the combined 2011 and 2012 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided by State and for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: mental-health, nsduh-data, samhsa, substance-use, washington-state
Organization: U.S. Department of Health & Human Services
Phenotypic silencing of cytoplasmic genes using sequence-specific double-stranded short interfering RNA and its application in the reverse genetics of wild type negative-strand RNA viruses

Background
          Post-transcriptional gene silencing (PTGS) by short interfering RNA has opened up new directions in the phenotypic mutation of cellular genes. However, its efficacy on non-nuclear genes and its effect on the interferon pathway remain unexplored. Since directed mutation of RNA genomes is not possible through conventional mutagenesis, we have tested sequence-specific 21-nucleotide long double-stranded RNAs (dsRNAs) for their ability to silence cytoplasmic RNA genomes.
        
        
          Results
          Short dsRNAs were generated against specific mRNAs of respiratory syncytial virus, a nonsegmented negative-stranded RNA virus with a cytoplasmic life cycle. At nanomolar concentrations, the dsRNAs specifically abrogated expression of the corresponding viral proteins, and produced the expected mutant phenotype ex vivo. The dsRNAs did not induce an interferon response, and did not inhibit cellular gene expression. The ablation of the viral proteins correlated with the loss of the specific mRNAs. In contrast, viral genomic and antigenomic RNA, which are encapsidated, were not directly affected.
        
        
          Conclusions
          Synthetic inhibitory dsRNAs are effective in specific silencing of RNA genomes that are exclusively cytoplasmic and transcribed by RNA-dependent RNA polymerases. RNA-directed RNA gene silencing does not require cloning, expression, and mutagenesis of viral cDNA, and thus, will allow the generation of phenotypic null mutants of specific RNA viral genes under normal infection conditions and at any point in the infection cycle. This will, for the first time, permit functional genomic studies, attenuated infections, reverse genetic analysis, and studies of host-virus signaling pathways using a wild type RNA virus, unencumbered by any superinfecting virus.

Tags: gene-silencing, nih, respiratory-syncytial-virus, rna-interference, viral-proteins
Organization: U.S. Department of Health & Human Services
Joint disease caused by defective gp130-mediated STAT signaling

IL-6 is a multifunctional cytokine produced by lymphoid and nonlymphoid cells; it regulates immune responses, acute-phase reactions, and inflammation. IL-6 signaling is mediated exclusively by the common signal-transducing component gp130, which is also essential for signal transduction of other cytokines of the leukemia inhibitory factor (LIF)/IL-6 family. M Ernst and colleagues generated and studied knock-in mice (gp130ΔSTAT/ΔSTAT), in which all STAT-binding sites (sites binding signal transducers and activators of transcription) were deleted from their gene encoding gp130 but binding sites for both Janus kinases (JAKs) and for the protein tyrosine phosphatase-2 (SHP-2) were preserved. They found that this mutant mouse displayed a blastocyst implantation defect, gastrointestinal ulceration, and, interestingly, severe joint disease with representative features of rheumatoid arthritis. Synovial cells from this mouse exhibited mitogenic hyper-responsiveness to cytokines of the LIF/IL-6 family, a phenomenon that was caused by sustained gp130-mediated SHP-2/Ras/Erk activation due to a defect in the induction of SOCS-1 (suppressor of cytokine signaling-1; also known as SSI or JAB). This suppressor, induced by STAT signaling, regulates cytokine signaling. It is, therefore, conceivable that the disturbance of the balanced activation between the STAT and SHP-2/Ras/Erk signal pathways causes the joint disease in the gp130ΔSTAT/ΔSTAT mouse. These findings may be beneficial in the elucidation of the cause and the treatment of rheumatoid arthritis in humans.

Tags: gp130-mediated-stat, il-6-signaling, joint-disease, nih, rheumatoid-arthritis
Organization: U.S. Department of Health & Human Services
2013 NSDUH Sample Design Report

The respondent universe for the 2013 National Survey on Drug Use and Health (NSDUH) was the civilian, noninstitutionalized population aged 12 years or older residing within the 50 States and the District of Columbia. Consistent with the NSDUH designs since 1991, the 2013 NSDUH universe included residents of noninstitutional group quarters (e.g., shelters, rooming houses, dormitories, and group homes), residents of Alaska and Hawaii, and civilians residing on military bases. Coverage before the 1991 survey was limited to residents of the coterminous 48 States, and it excluded residents of group quarters and all persons (including civilians) living on military bases. Persons excluded from the 2013 universe included those with no fixed household address (e.g., homeless and/or transient persons not in shelters), the active military, and residents of institutional group quarters, such as jails and hospitals.

Tags: mental-health, samhsa, sample-design, substance-use, survey-methodology
Organization: U.S. Department of Health & Human Services
2016 Uniform Reporting System (URS) Table for Ohio

This is the 2016 Uniform Reporting System (URS) Output Tables for Ohio. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-program, mental-health-services, national-outcome-measures, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
Table 8. Nonmedical Use of Pain Relievers in the Past Year, by Age Group and State: Percentages, Annual Averages Based on 2010 and 2011 NSDUHs

This report presents State estimates for measures of past year non-medical use of pain relievers based on the combined 2010 and 2011 National Surveys on Drug Use and Health (NSDUHs). Resuts are provided by age group.

Tags: age-groups, nsduh-survey, pain-reliever-misuse, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Compound 528496: 7-Methylheneicosane

Chemical compound data from PubChem database. IUPAC Name: 7-methylhenicosane. Molecular Formula: C22H46. Molecular Weight: 310.6. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Icodextrin as salvage therapy in peritoneal dialysis patients with refractory fluid overload

Background
          Icodextrin is a high molecular weight, starch-derived glucose polymer, which is capable of inducing sustained ultrafiltration over prolonged (12–16 hour) peritoneal dialysis (PD) dwells. The aim of this study was to evaluate the ability of icodextrin to alleviate refractory, symptomatic fluid overload and prolong technique survival in PD patients.
        
        
          Methods
          A prospective, open-label, pre-test/post-test study was conducted in 17 PD patients (8 females/9 males, mean age 56.8 ± 2.9 years) who were on the verge of being transferred to haemodialysis because of symptomatic fluid retention that was refractory to fluid restriction, loop diuretic therapy, hypertonic glucose exchanges and dwell time optimisation. One icodextrin exchange (2.5 L 7.5%, 12-hour dwell) was substituted for a long-dwell glucose exchange each day.
        
        
          Results
          Icodextrin significantly increased peritoneal ultrafiltration (885 ± 210 ml to 1454 ± 215 ml, p < 0.05) and reduced mean arterial pressure (106 ± 4 to 96 ± 4 mmHg, p < 0.05), but did not affect weight, plasma albumin concentration, haemoglobin levels or dialysate:plasma creatinine ratio. Diabetic patients (n = 12) also experienced improved glycaemic control (haemoglobin Alc decreased from 8.9 ± 0.7% to 7.9 ± 0.7%, p < 0.05). Overall PD technique survival was prolonged by a mean of 11.6 months (95% CI 6.0–17.3 months). On multivariate Cox proportional hazards analysis, extension of technique survival by icodextrin was only significantly predicted by baseline net daily peritoneal ultrafiltration (adjusted HR 2.52, 95% CI 1.13–5.62, p < 0.05).
        
        
          Conclusions
          Icodextrin significantly improved peritoneal ultrafiltration and extended technique survival in PD patients with symptomatic fluid overload, especially those who had substantially impaired peritoneal ultrafiltration.

Tags: fluid-overload, icodextrin-therapy, nih, peritoneal-dialysis, ultrafiltration
Organization: U.S. Department of Health & Human Services
Compound 528591: tert-Butyl(dimethyl)silyl phenylacetate

Chemical compound data from PubChem database. IUPAC Name: [tert-butyl(dimethyl)silyl] 2-phenylacetate. Molecular Formula: C14H22O2Si. Molecular Weight: 250.41. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2013 NSDUH Trend Tables  (Prevalence Estimates) - 7.1 to 7.45

These detailed tables show trends in population totals and prevalence estimates of illicit drug use, risk and protective factors, substance initiation, substance dependence/abuse, and need/receipt of substance use treatment from the 2013 National Survey on Drug Use and Health (NSDUH). Substances examined include illicit drugs (e.g., marijuana, cocaine, heroin, hallucinogens (including LSD, PCP, Ecstasy, Ketamine, DMT/AMT/Foxy, Salvia divinorum), inhalants, and the nonmedical use of prescription-type pain relievers (including OxyContin), tranquilizers, stimulants (Adderall) , sedatives (GHB, Ambien), non-prescription cold medicine, alcohol, and tobacco products (including cigarettes, smokeless tobacco, cigars, pipes). Results are provided for lifetime, past year, and past month use by age group, gender, race/ethnicity, education level, employment status, and geographic area. Comparisons are made between 2013 and 2002 through 2012.

Tags: illicit-drug-use, nsduh-2013, prescription-drug-misuse, samhsa, substance-use-trends
Organization: U.S. Department of Health & Human Services
2012 State Profile - Illinois

This is a National Survey of Substance Abuse Treatment Services (N-SSATS) annual report showing the state profile for Illinois in 2012. N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 States, the District of Columbia, and other U.S. jurisdictions.

Tags: alcohol-drug-services, illinois-health, n-ssats, samhsa, substance-abuse-treatment
Organization: U.S. Department of Health & Human Services
Miami - Dade Div: Drug-Related Emergency Department Visits, 2004-2011 - Suicide Attempts

Excel file with estimates, rates, relative standard errors, trends and confidence intervals for all drug-related emergency department (ED) visits involving suicide attempts in the Dade division of the Miami metropolitan area, covering 2004-2011.  Drug-related suicide attempts include visits for drug overdoses and for suicide attempts by other means (e.g., using a firearm) if drugs were involved or related to the suicide attempt.

Tags: drug-overdose, emergency-department, miami-dade-county, samhsa, suicide-attempts
Organization: U.S. Department of Health & Human Services
Compound 525086: [10,13-dimethyl-17-(6-methylheptan-2-yl)-3-trimethylsilyloxy-6,7,8,9,11,12,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-7-yl]oxy-trimethylsilane

Chemical compound data from PubChem database. IUPAC Name: [10,13-dimethyl-17-(6-methylheptan-2-yl)-3-trimethylsilyloxy-6,7,8,9,11,12,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-7-yl]oxy-trimethylsilane. Molecular Formula: C33H60O2Si2. Molecular Weight: 545.0. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 528539: Hexadecane, 7-octyl

Chemical compound data from PubChem database. IUPAC Name: 9-hexyloctadecane. Molecular Formula: C24H50. Molecular Weight: 338.7. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Comparison of 2014-2016 and 2016-2018 NSDUH Substate Region Estimates

Tables showing the 2014-2016 and 2016-2018 substate area estimates and the percent Bayesian confidence intervals along with an indication of statistical significance of the difference.

Tags: behavioral-health, mental-health, nsduh-data, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Publications Using SAMHSA DataComparison of 2008-2010 and 2016-2018 NSDUH Substate Region Estimates

Tables showing the 2008-2010 and 2016-2018 substate area estimates and the percent Bayesian confidence intervals along with an indication of statistical significance of the difference.

Tags: mental-health, nsduh-data, samhsa, statistical-significance, substance-use
Organization: U.S. Department of Health & Human Services
About 1 in 4 Mental Health Treatment Facilities Offered Services to Quit Smoking

This report is a spotlight using the 2010 National Mental Health Services Survey (NMHSS).  The spotlight highlights the percentage of specialty mental health treatment facilities that provide smoking cessation programs.

Tags: mental-health-facilities, nmhss, samhsa, smoking-cessation, tobacco-use
Organization: U.S. Department of Health & Human Services