AndreaBozzo/ceres-open-data-index huggingface dataset:
Guidance to tribes on actions required to complete and submit the (1) Final Report for FYs 2020-2024; (2) the new CFSP for FYs 2025- 2029; and (3) the CFS-101, Parts I, II, and III.

This Program Instruction (PI) provides guidance to Indian Tribes, Indian Tribal Organizations and Indian Tribal Consortia (hereafter “Tribes,” unless otherwise noted) on actions they are required to take to receive their allotments authorized under title IV-B, subparts 1 and 2, and Chafee and ETV programs for Federal Fiscal Year (FY)2 2025 (subject to the availability of appropriations). This PI summarizes requirements for completing and submitting: (1) the Final Report for the 2020-2024 CFSP (2) the new 2025-2029 CFSP, and (3) the CFS-101, Parts I, II, and III.

PI-24-03 (PDF)

For the best access to each attachment, please download and save them to your computer.

FY 2023 Allotment for Title IV-B, Subpart 1 Stephanie Tubbs Jones Child Welfare Services GrantsFY 2023 Allotment for Title IV-B, Subpart 2 Promoting Safe and Stable Families GrantsFY 2023 Allotment for Title IV-B, Subpart 2 Kinship Navigator GrantsFY 2023 Allotment for Chafee Foster Care Program for Successful Transition to Adulthood GrantsFY 2023 Allotment for Education and Training Vouchers GrantsFY 2020 Allotment for Family First Prevention Services Act Transition Grants

CFS-101 Instructions, Part I, II, and III (PDF)

IntroductionPart I: Annual Budget Request for Title IV-B, Subpart 1 & 2 Funds, CAPTA, Chafee, and ETV InstructionsPart II: Annual Estimated Expenditure Summary of Child and Family Services InstructionsPart III: Expenditures for Title IV-B, Subparts 1 and 2, Chafee Foster Care Independence (Chafee) and Education and Training Voucher (ETV) Programs Instructions

CFS-101 Forms, Parts I, II and III Excel Workbook (XLSX)

Assurances and Certifications

Title IV-B, subparts 1 and 2 (PDF)Chafee (PDF)ETV (PDF)

CB Regional Program Managers (PDF)

Tribal Training Plan (Optional) Template (DOCX)

Annual Reporting of Education and Training Vouchers Awarded (PDF)

Certification of Tribal Population Under Age 21 (DOCX)

Tribal CFSP (Optional) Template for FYs 2025-2029 (DOCX)

Tribal Population Data - 2020 Census (PDF)

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: child, fiscal, guidance, instruction, policy
Organization: U.S. Department of Health & Human Services
2010 State Profile — Tennessee

This state profile includes data from facilities in Tennessee that reported to N-SSATS for the survey reference date March 31, 2010. Data were collected on the location, characteristics, services offered, and number of clients in treatment at alcohol and drug abuse treatment facilities (both public and private) in Tennessee. In Tennessee, 202 substance abuse treatment facilities were included in the 2010 N-SSATS, reporting that there were 17,451 clients in substance abuse treatment on March 31, 2010. The survey response rate in Tennessee was 94.7%.

Tags: addiction-services, n-ssats, samhsa, substance-abuse-treatment, tennessee
Organization: U.S. Department of Health & Human Services
2011 CMHS Uniform Reporting System (URS) Output Tables for Arizona

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2011. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, national-outcome-measures, samhsa, urs-data
Organization: U.S. Department of Health & Human Services
Compound 525533: (3-Methoxy-4-hexyloxy-phenyl)-propionic acid, methyl ester

Chemical compound data from PubChem database. IUPAC Name: methyl 3-(4-hexoxy-3-methoxyphenyl)propanoate. Molecular Formula: C17H26O4. Molecular Weight: 294.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Age of Substance Use Initiation among Treatment Admissions Aged 18 to 30

This is a Treatment Episode Data Set (TEDS) short report showing the age of substance use initiation among treatment admissions aged 18 to 30 in 2011. The Treatment Episode Data Set (TEDS) is a national data system of annual admissions to substance abuse treatment facilities. TEDS received treatment admission records from 46 states, the District of Columbia, and Puerto Rico in 2011.

Tags: age-initiation, samhsa, substance-use, teds-data, treatment-admissions
Organization: U.S. Department of Health & Human Services
Risk factors for hepatitis C virus infection among blood donors in southern Brazil: a case-control study

Background
          In Brazil, it is estimated that between 2.5 and 4.9% of the general population present anti-hepatitis C virus (HCV) antibodies, which corresponds to as many as 3.9 to 7.6 million chronic carriers. Chronic liver disease is associated with HCV infection in 20% to 58% of the Brazilian patients. The objective of this case-control study was to investigate the risk factors for presence of anti-HCV antibody in blood donors in southern Brazil.
        
        
          Methods
          One hundred and seventy eight blood donors with two positive ELISA results for anti-HCV were cases, and 356 controls tested negative. A standardized questionnaire was used to collect data concerning demographic and socioeconomic aspects, history of previous hepatitis infection, social and sexual behaviors, and number of donations. Variables were grouped into sets of hierarchical categories. Cases and controls were compared using logistic regression, odds ratios, and 95% confidence intervals. The statistical significance of the associations was assessed through likelihood ratio tests based on a P value < 0.05.
        
        
          Results
          The prevalence of anti-HCV among blood donors was 1.1%. Most of the donors were white and males. In the multivariate analysis, independent predictors of anti-HCV positivity were: intravenous drug use, blood transfusion >10 years earlier, having had two to four sexually transmitted diseases, incarceration, tattooing, sex with a hepatitis B or C virus carrier or with intravenous drug users.
        
        
          Conclusion
          Intravenous drug use, blood transfusion, and tattooing were the main risk factors for anti-HCV positivity among blood donors from southern Brazil, but sexual HCV transmission should also be considered.

Tags: blood-donors, case-control-study, hepatitis-c, nih, risk-factors
Organization: U.S. Department of Health & Human Services
The Distributed Annotation System

Background
          Currently, most genome annotation is curated by centralized groups with limited resources. Efforts to share annotations transparently among multiple groups have not yet been satisfactory.
        
        
          Results
          Here we introduce a concept called the Distributed Annotation System (DAS). DAS allows sequence annotations to be decentralized among multiple third-party annotators and integrated on an as-needed basis by client-side software. The communication between client and servers in DAS is defined by the DAS XML specification. Annotations are displayed in layers, one per server. Any client or server adhering to the DAS XML specification can participate in the system; we describe a simple prototype client and server example.
        
        
          Conclusions
          The DAS specification is being used experimentally by Ensembl, WormBase, and the Berkeley Drosophila Genome Project. Continued success will depend on the readiness of the research community to adopt DAS and provide annotations. All components are freely available from the project website .

Tags: bioinformatics, distributed-systems, genome-annotation, nih, sequence-annotation
Organization: U.S. Department of Health & Human Services
2010 State Profile — Delaware

This state profile includes data from facilities in Delaware that reported to N-SSATS for the survey reference date March 31, 2010. Data were collected on the location, characteristics, services offered, and number of clients in treatment at alcohol and drug abuse treatment facilities (both public and private) in Delaware. In Delaware, 37 substance abuse treatment facilities were included in the 2010 N-SSATS, reporting that there were 4,981 clients in substance abuse treatment on March 31, 2010. The survey response rate in Delaware was 94.9%.

Tags: alcohol-drug-abuse, delaware, n-ssats, samhsa, substance-abuse-treatment
Organization: U.S. Department of Health & Human Services
Chicago: Drug-Related Emergency Department Visits, 2004-2011 - Underage Drinking

Excel file with estimates, rates, relative standard errors, trends and confidence intervals for all drug-related emergency department (ED) visits involving underage drinking in the Chicago metropolitan area, covering 2004-2011.  Underage drinking includes ED visits that involve alcohol use (alone or with other drugs) for patients under the age of 21.

Tags: alcohol-related-visits, chicago-metro-area, emergency-department, samhsa, underage-drinking
Organization: U.S. Department of Health & Human Services
Distinct gene expression profiles of human type 1 and type 2 T helper cells

Background
          The development and activation of CD4+ helper T cell (Th) subsets with distinct patterns of unbalanced production of cytokines play an important part in infectious, allergic and autoimmune diseases. Human neonatal cord blood CD4+ Th cells can be polarized into type 1 or type 2-like effector cells in vitro by culturing them in the presence of interleukin (IL)-12 or IL-4, respectively. We have exploited this experimental system to identify marker genes that are differentially expressed by polarized Th1 and Th2 cells. An oligonucleotide microarray specifically designed to screen for inflammation-related candidate genes was used and the differential expression was further validated with a quantitative real-time RT-PCR method.
        
        
          Results
          In addition to the previously described marker genes of Th cells, we report subtle changes in the expression of several other genes that represent growth factors, receptors and other signaling molecules in polarized Th1 and Th2 cell subsets. Additionally, we describe a novel set of genes as Th1/Th2 differentiation markers for cells activated by anti-CD3 and anti-CD28 antibodies.
        
        
          Conclusions
          This study demonstrates the power of the targeted use of microarrays in combination with quantitative real-time RT-PCR in identifying and validating new marker genes for gene expression studies.

Tags: cytokine-production, gene-expression-profiling, nih, t-helper-cells, th1-th2-differentiation
Organization: U.S. Department of Health & Human Services
Airway obstruction in asthma: does the response to a deep inspiration matter?

Airway hyperresponsiveness in asthma may not be a problem of too much airway smooth muscle strength. Rather, it may be a problem of too little of the factors that oppose muscle shortening. The weight of available evidence seems to support the idea that loss of the dilating response to a deep inspiration may play a central role in this process, and that the locus of the response is within the airway smooth muscle cell. Bridge dynamics and plastic reorganization of the smooth muscle cytoskeleton are the focus of this commentary; how these factors interact and details about underlying mechanisms remain unclear.

Tags: airway-smooth-muscle, asthma-airway-obstruction, bronchial-hyperresponsiveness, deep-inspiration-response, nih
Organization: U.S. Department of Health & Human Services
Cloud Computing Service Models Webinar

This webinar, featuring Terry Watt (Director, Division of State Systems), Nicole Harter-Shafer (Federal Analyst, Division of State Systems), and Nick Gompper (contracted technology specialist), provided technical assistance about cloud service computing models.  The webinar distinguished between Infrastructure-as-a-Service, Platform-as-a-Service, Software-as-a-Service, and Commercial-off-the-Shelf (COTS) solutions and the webinar included items to consider when evaluating solutions for a specific title IV-E agency need.  In addition, Terry Watt and Nicole Harter-Shafer provided technical assistance about selecting a solution, when to use a COTS waiver, and sole-source justification.  The webinar included several question and answer sessions throughout the presentation.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: guidance, metadata, policy, scope, service
Organization: U.S. Department of Health & Human Services
Revised Technical Bulletin #1

This technical bulletin is a revision to the Technical Bulletin #1 that was originally published on August 19, 2019.  This revised Technical Bulletin #1 provides additional information regarding the file structure for the data elements to be submitted by IV-E agencies for each child who received IV-E prevention services, as required by FFPSA.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: compliance, data, guidance, policy, prevention
Organization: U.S. Department of Health & Human Services
National Directory of Drug and Alcohol Abuse Treatment Facilities - 1991

The National Directory of Drug and Alcohol Abuse Treatment Programs 1991 lists federal, state, local, and private facilities that provide substance abuse treatment services. The directory includes treatment facilities that are licensed, certified, or otherwise approved for inclusion in the directory by their state substance abuse agencies and that responded to the 1990 National Survey of Substance Abuse Treatment Services (N-SSATS). The information about each facility that appears in this directory was provided by that facility in response to the 1990 N-SSATS. The Substance Abuse and Mental Health Services Administration (SAMHSA) conducts the N-SSATS annually.

Tags: alcohol-abuse-treatment, n-ssats, samhsa, substance-abuse-treatment, treatment-facility-directory
Organization: U.S. Department of Health & Human Services
Compound 527297: Propanoic acid, 2-methyl, 2-iodoethyl ester

Chemical compound data from PubChem database. IUPAC Name: 2-iodoethyl 2-methylpropanoate. Molecular Formula: C6H11IO2. Molecular Weight: 242.05. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
The International Sepsis Forum's controversies in sepsis: corticosteroids should be used to treat septic shock

The use of corticosteroids in septic shock remains controversial. It has been demonstrated that high doses of steroids (30 mg/kg methylprednisolone) for short periods of time are not beneficial. More recent studies using smaller doses (200–300 mg/day hydrocortisone) for longer periods of time have shown beneficial effects. These positive effects have included reversal of shock, trends toward decreased organ system dysfunction and decreased mortality. Based on the high proportion of patients who have relative adrenal insufficiency, the benefits of low doses of steroids and the minimal risks, steroids should be used to treat septic shock.

Tags: adrenal-insufficiency, corticosteroid-treatment, mortality-rate, nih, septic-shock
Organization: U.S. Department of Health & Human Services
Child Welfare Training

This program upgrades the skills, knowledge and qualifications of prospective and current child welfare agency staff and supports special projects for training personnel to work in the field of child welfare. These discretionary grants are awarded to public and private non-profit institutions of higher learning and are designed to assist State child welfare agencies in developing a stable and highly skilled workforce for providing effective child welfare services. Further, the Child Welfare Discretionary Grant Projects develop and maintain a strong University- Public Agency Partnership toward the goal of identifying and developing the appropriate staff competencies.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: child, grant, policy, real, time
Organization: U.S. Department of Health & Human Services
What is the optimal prophylaxis for treatment of cardiac allograft vasculopathy?

Coronary artery disease in the transplanted heart, also known as cardiac allograft vasculopathy (CAV), is one of the major causes of mortality late after transplantation. It affects up to 50% of all heart transplant recipients within 5 years of surgery. The mechanisms of CAV are multifactorial and include both immune and nonimmune factors. Ischemia of the graft at the time of transplantation is one of the more important nonimmune factors, because this leads to endothelial cell injury. Immune factors involving cellular and humoral rejection can further insult the vascular endothelial cell, leading to a cascade of immunologic responses. The optimal treatment prophylaxis for CAV has not been established. The treatment approach to this major post-transplant complication includes modification of risk factors through medical therapies and strategies. The early use of diltiazem and/or pravastatin or simvastatin has been demonstrated to be effective in reducing the development of CAV, but does not completely prevent it. There are many ongoing studies involving newer immunosuppressive agents that may hold promise for the future.

Tags: cardiac-allograft-vasculopathy, coronary-artery-disease, heart-transplantation, nih, prophylactic-treatment
Organization: U.S. Department of Health & Human Services
2015 CMHS Uniform Reporting System (URS) Table for California

2015 Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for California. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: california-mental-health, mental-health-services, noms-measures, samhsa, substance-abuse-treatment
Organization: U.S. Department of Health & Human Services
The CXC chemokine cCAF stimulates precocious deposition of ECM molecules by wound fibroblasts, accelerating development of granulation tissue

Background
          During wound repair, fibroblasts orchestrate replacement of the provisional matrix formed during clotting with tenascin, cellular fibronectin and collagen III. These, in turn, are critical for migration of endothelial cells, keratinocytes and additional fibroblasts into the wound site. Fibroblasts are also important in the deposition of collagen I during scar formation. The CXC chemokine chicken Chemotactic and Angiogenic Factor (cCAF), is highly expressed by fibroblasts after wounding and during development of the granulation tissue, especially in areas where extracellular matrix (ECM) is abundant. We hypothesized that cCAF stimulates fibroblasts to produce these matrix molecules.
        
        
          Results
          Here we show that this chemokine can stimulate precocious deposition of tenascin, fibronectin and collagen I, but not collagen III. Studies in culture and in vivo show that tenascin stimulation can also be achieved by the N-terminal 15 aas of the protein and occurs at the level of gene expression. In contrast, stimulation of fibronectin and collagen I both require the entire molecule and do not involve changes in gene expression. Fibronectin accumulation appears to be linked to tenascin production, and collagen I to decreased MMP-1 levels. In addition, cCAF is chemotactic for fibroblasts and accelerates their migration.
        
        
          Conclusions
          These previously unknown functions for chemokines suggest that cCAF, the chicken orthologue of human IL-8, enhances healing by rapidly chemoattracting fibroblasts into the wound site and stimulating them to produce ECM molecules, leading to precocious development of granulation tissue. This acceleration of the repair process may have important application to healing of impaired wounds.

Tags: chemokine-ccaf, extracellular-matrix, fibroblast-stimulation, nih, wound-healing
Organization: U.S. Department of Health & Human Services
Compound 528361: 1,2,3,5-Trithiazine, perhydro, 4,6-dimethyl

Chemical compound data from PubChem database. IUPAC Name: 4,6-dimethyl-1,2,3,5-trithiazinane. Molecular Formula: C4H9NS3. Molecular Weight: 167.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Indiana 2016 Potential Areas for Addressing Service Gaps for Opioid Treatment

The purpose of the medication-assisted treatment (MAT) facility maps is to identify areas on a state-by-state basis that may be potentially underserved by existing treatment facilities. The maps are created with a methodology that seeks to include the highest potential need areas from individual counties so that county-level stakeholders are also informed. The maps are meant to be used as a tool for policy makers to determine potentially underserved areas—not as a definitive representation of these areas.

Tags: indiana, mat-facilities, opioid-treatment, samhsa, service-gap-analysis
Organization: U.S. Department of Health & Human Services
Supporting Evidence-Based Home Visitation Programs to Prevent Child Abuse and Neglect Project: The University of Oklahoma Health Sciences Center

Location:

Oklahoma City, Oklahoma

Home Visiting Program Selected:

SafeCare

Home Visiting Target Population:

Families with at least one child age 5 years or younger and at least one of the following risk factors: parental substance abuse, mental health issues, and/or intimate partner violence.

Project Overview:
The University of Oklahoma Health Sciences Center will build on their experience developing, implementing, evaluating, and expanding evidence-based home visiting programs serving high-risk populations. Oklahoma will evaluate SafeCare® augmented to address risks of intimate partner violence, substance abuse, and depression with Motivational Interviewing, safety planning, and problem solving (SafeCare+). Through this grant, Oklahoma will expand the SafeCare+ model by selecting an evidence-based augmentation to promote nonviolent behavior and conflict resolution skills, and implementing adaptations for receptivity and cultural congruency for the Oklahoma Latino community. Oklahoma will conduct a randomized trial comparing SafeCare+ to one or more other home-based service approaches offered at the Latino Community Development Agency. The violence prevention augmentation will also be evaluated in an ongoing randomized trial. To focus on systems change, the Sustaining Prevention Programs committee will examine private, municipal, state, and federal funding streams and cost benefits data to plan for the continuation and expansion of evidence-based high risk child maltreatment prevention in Oklahoma.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: abuse, mental, neglect, prevention, substance
Organization: U.S. Department of Health & Human Services