AndreaBozzo/ceres-open-data-index huggingface dataset:
2014 NSDUH MRB Sample Experience Report

A coordinated sample design was developed for the 2014 through 2017 National Surveys on Drug Use and Health (NSDUHs).  The multiyear design consists of a deeply stratified, multistage area probability design. The 2014 sample design is thoroughly documented in the 2014 NSDUH sample design report (Center for Behavioral Health Statistics and Quality, 2015a). The goal of this report is to further document the 2014 NSDUH sample experiences, including a comparison of actual sample yields to state and quarter targets, a comparison of achieved and expected design effects (DEFFs) and relative standard errors (RSEs), and documentation of any issues encountered during sample implementation. In addition, any unforeseen issues related to the 2014 sample redesign will be documented.

Tags: mental-health, samhsa, sample-design, substance-use, survey-data
Organization: U.S. Department of Health & Human Services
Compound 525598: N,N-Dimethyl-N'-(4-methoxyphenyl)-benzamidine

Chemical compound data from PubChem database. IUPAC Name: N'-(4-methoxyphenyl)-N,N-dimethylbenzenecarboximidamide. Molecular Formula: C16H18N2O. Molecular Weight: 254.33. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Idaho, 2015

This is a behavioral health report for the state of Idaho. The report utilizes data from the National Survey on Drug Use and Health (NSDUH), and the Uniform Reporting System. The topics addressed in the report include youth substance use, youth mental health and treatment, mental health and treatment, substance use and substance use treatment.

Tags: idaho-behavioral-health, mental-health-treatment, nsduh-data, samhsa, youth-substance-use
Organization: U.S. Department of Health & Human Services
M-8: Reliability of Key Measures in the National Survey on Drug Use and Health

This National Survey on Drug Use and Health (NSDUH) methodological report presents findings from a reinterview study of respondents to assess the reliability of NSDUH data and identify questions of low reliability.

Tags: data-quality, nsduh-reliability, reinterview-study, samhsa, substance-use-survey
Organization: U.S. Department of Health & Human Services
2021 Uniform Reporting System (URS) Table For Colorado

This is the 2021 Uniform Reporting System (URS) Output Tables for Colorado. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, evidence-based-practices, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Medication-Assisted Treatment Facility Maps (MAT)

The purpose of the medication-assisted treatment (MAT) facility maps is to identify areas on a state-by-state basis that may be potentially underserved by existing treatment facilities. The maps are created with a methodology that seeks to include the highest potential need areas from individual counties so that county-level stakeholders are also informed. The maps are meant to be used as a tool for policy makers to determine potentially underserved areas—not as a definitive representation of these areas.For more information on the methodology used by the Center for Behavioral Health Statistics and Quality (CBHSQ) to create this set of state maps showing specific areas (census tracts) that are potentially underserved by medication-assisted treatment (MAT) facilities, please clickhere[PDF 847KB].

Tags: mat-facilities, opioid-treatment, samhsa, substance-use, underserved-areas
Organization: U.S. Department of Health & Human Services
Table 22. Needing But Not Receiving Treatment for Illicit Drug Use in the Past Year among Persons Aged 12 or Older, by State and Substate Regions: Percentages, Annual Averages Based on 2008, 2009, and 2010 NSDUHs

This table presents the 2008 to 2010 National Survey on Drug Use and Health (NSDUH) estimates of past year need for but not reciept of treatment for illicit drug use by those aged 12 or older by State and substate regions.

Tags: drug-use-treatment, nsduh-data, samhsa, substate-data, unmet-treatment-need
Organization: U.S. Department of Health & Human Services
Fibroblast biology: Role of synovial fibroblasts in the pathogenesis of rheumatoid arthritis

There is growing evidence that activated synovial fibroblasts, as part of a complex cellular network, play an important role in the pathogenesis of rheumatoid arthritis. In recent years, significant progress has been made in elucidating the specific features of these fibroblasts. It has been understood that although macrophage and lymphocyte secreted factors contribute to their activation, rheumatoid arthritis synovial fibroblasts (RA-SFs) do not merely respond to stimulation by pro-inflammatory cytokines, but show a complex pattern of molecular changes also maintained in the absence of external stimulation. This pattern of activation is characterized by alterations in the expression of regulatory genes and signaling cascades, as well as changes in pathways leading to apoptosis. These together result in the upregulation of adhesion molecules that mediate the attachment of RA-SFs to the extracellular matrix and in the overexpression of matrix degrading enzymes that mediate the progressive destruction of the joints. In addition, activated RA-SFs exert specific effects on other cell types such as macrophages and lymphocytes. While the initiating step in the activation of RA-SFs remains elusive, several key pathways of RA-SF activation have been identified. However, there is so far no single, specific marker for this phenotype of RA-SF. It appears that activated RA-SFs are characterized by a set of specific properties which together lead to their aggressive behavior.

Tags: arthritis-pathogenesis, fibroblast-biology, nih, rheumatoid-arthritis, synovial-fibroblasts
Organization: U.S. Department of Health & Human Services
Compound 525164: Heptapropylene glycol, monoallyl ether, acetate

Chemical compound data from PubChem database. IUPAC Name: 1-[1-[1-[1-[1-[1-(1-prop-2-enoxypropan-2-yloxy)propan-2-yloxy]propan-2-yloxy]propan-2-yloxy]propan-2-yloxy]propan-2-yloxy]propan-2-yl acetate. Molecular Formula: C26H50O9. Molecular Weight: 506.7. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 525264: N'-(1-naphthyl)-N,N-dimethyl-formamidine

Chemical compound data from PubChem database. IUPAC Name: N,N-dimethyl-N'-naphthalen-1-ylmethanimidamide. Molecular Formula: C13H14N2. Molecular Weight: 198.26. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Availability of Fiscal Year (FY) 2024 Funds Under the Community-Based Grants for the Prevention of Child Abuse and Neglect Program

This Program Instruction (PI) sets forth the requirements for recipients of Community-Based Grants for the Prevention of Child Abuse and Neglect awards for FY 2024 and provides guidance and instructions for the preparation and submission of the application and annual reports.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: abuse, fiscal, grant, neglect, prevention
Organization: U.S. Department of Health & Human Services
National Estimates of Drug-Related Emergency Department Visits, 2004-2011 - Seeking Detox

Excel file with national estimates, rates, relative standard errors, trends and confidence intervals for all drug-related emergency department (ED) visits involving patients seeking detox, covering 2004-2011. This includes nonemergency requests made through the ED for admission to detoxification unit, visits to obtain medical clearance before being incarcerated, and acute emergencies where an individual is experiencing withdrawal symptoms and requests detox. These estimates do not include patients who seek or enter the hospital\'s detox unit through other avenues.

Tags: detoxification-seeking, drug-related-ed-visits, emergency-department-data, samhsa, substance-use-disorder
Organization: U.S. Department of Health & Human Services
CFSR Reviewer Qualifications

The Child Welfare Reviews Project assists the Children's Bureau in recruiting and maintaining a national pool of Child and Family Services Review (CFSR) reviewers, who are qualified child welfare professionals who meet established minimum education and experience requirements. The qualifications for individuals interested in participating as CFSR Reviewers are discussed below.

CFSR reviewers, quality assurance specialists, and note-taking specialists (collectively referred to as “agile staff”) are child welfare experts with experience in making professional judgments based on information collected from various sources. They apply this knowledge to participate in the CFSRs. The following are the minimum qualifications for agile staff:

The following are the preferred qualifications for CFSR reviewers:

Preference will be given to individuals who are experienced in applying the Onsite Review Instrument and Instructions and/or demonstrate fluency in Spanish and/or lived experience within the child welfare system or within indigenous or tribal social services.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: assessment, child, policy, real, time
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Region 8, Volume 7

Explore state and regional data for HHS Region 8 with this user-friendly behavioral health report. It uses data from the 2021-2022 National Surveys on Drug Use and Health (NSDUH). The topics addressed in this report include substance use, substance use disorders, and mental health. Selected estimates are provided for adolescents aged 12 to 17, underage people aged 12 to 20, adults aged 18 or older, and the general population aged 12 or older. Statistical tests compare population percentages of (1) HHS region versus national estimates, (2) state versus national estimates, and (3) state versus HHS region estimates.

Tags: behavioral-health, mental-health, nsduh-data, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Ablation of atrial fibrillation: a procedure come of age?

Various approaches for catheter ablation of focal initiators of atrial fibrillation or the substrate for maintaining atrial fibrillation have evolved over the past 5 years. Despite these advances, there are still a large number of unresolved issues regarding the efficacy and safety of these procedures as well as optimal patient selection for the different approaches. These uncertainties raise questions about the applicability at the present time of atrial fibrillation as front-line therapy within the community.

Tags: arrhythmia-treatment, atrial-fibrillation, catheter-ablation, nih, pulmonary-vein-isolation
Organization: U.S. Department of Health & Human Services
Compound 525398: 2,8-Dimethyl-3,7-dithianonane

Chemical compound data from PubChem database. IUPAC Name: 1,3-bis(propan-2-ylsulfanyl)propane. Molecular Formula: C9H20S2. Molecular Weight: 192.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
A role for the collagen I/III and MMP-1/-13 genes in primary inguinal hernia?

Background
          Abnormal collagen metabolism is thought to play an important role in the development of primary inguinal hernia. This is underlined by detection of altered collagen metabolism and structural changes of the tissue in patients with primary inguinal hernia. However, it is still unknown whether these alterations reflect a basic dysfunction of the collagen synthesis, or of collagen degradation.
        
        
          Methods
          In the present study, we analysed type I and type III procollagen messenger ribonucleic acid (mRNA) and MMP-1 and MMP-13 mRNA in cultured fibroblasts from the skin of patients with primary inguinal hernia, and from patients without hernia (controls) by reverse transcription polymerase chain reaction (RT-PCR) and Northern Blot.
        
        
          Results
          The results indicated that the ratio of type I to type III procollagen mRNA was decreased in patients with primary hernia, showing significant differences as compared to controls (p = 0.01). This decrease was mainly due to the increase of type III procollagen mRNA. Furthermore, RT-PCR analysis revealed that the expression of MMP-1 mRNA in patients with primary hernia is equivalent to that of controls (p > 0.05). In addition, MMP-13 mRNA is expressed neither in patients with primary hernia nor in controls.
        
        
          Conclusion
          We concluded that abnormal change of type I and type III collagen mRNAs contribute to the development of primary inguinal hernia, whereas the expressions of MMP-1 and MMP-13 mRNA appears not to be involved in the development of primary inguinal hernia. Thus, the knowledge on the transcriptional regulation of collagen in patients with primary inguinal hernia may help to understand the pathogenesis of primary inguinal hernia, and implies new therapeutic strategies for this disease.

Tags: collagen-metabolism, gene-expression, inguinal-hernia, nih, rt-pcr
Organization: U.S. Department of Health & Human Services
Idiopathic pulmonary fibrosis: an epithelial/fibroblastic cross-talk disorder

Idiopathic pulmonary fibrosis is a chronic and usually progressive lung disorder of unknown etiology. A growing body of evidence suggests that, in contrast to other interstitial lung diseases, IPF is a distinct entity in which inflammation is a secondary and non-relevant pathogenic partner. Evidence includes the presence of similar mild/moderate inflammation either in early or late disease, and the lack of response to potent anti-inflammatory therapy. Additionally, it is clear from experimental models and some human diseases that it is possible to have fibrosis without inflammation. An evolving hypothesis proposes that IPF may result from epithelial micro-injuries and abnormal wound healing.

Tags: epithelial-fibroblastic-cross-talk, idiopathic-pulmonary-fibrosis, lung-fibrosis, nih, wound-healing
Organization: U.S. Department of Health & Human Services
2021 Uniform Reporting System (URS) Table For Massachusetts

This is the 2021 Uniform Reporting System (URS) Output Tables for Massachusetts. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-data, massachusetts-data, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Compound 525437: 3,5-Dithiaoctane

Chemical compound data from PubChem database. IUPAC Name: 1-(ethylsulfanylmethylsulfanyl)propane. Molecular Formula: C6H14S2. Molecular Weight: 150.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Lack of correlation between Ki-67 labelling index and tumor size of anterior pituitary adenomas

Aims and background
          The Ki-67 is a nuclear antigen detected by the monoclonal antibody MIB-1 and its Labeling Index (LI) is considered a marker of normal and abnormal cell proliferation. Pituitary adenomas are generally well differentiated neoplasms, even if in about one third of cases they are invasive of surrounding tissues. The aim of this study is to evaluate the correlation between Ki-67 labelling index and tumor size of pituitary adenomas extimated by means CT and MRI and confirmed at operation.
        
        
          Methods
          Using the monoclonal antibody MIB-1, we evaluated the expression of Ki-67 in 121 anterior pituitary adenomas consecutively operated on in a 48-month period.
        
        
          Results
          In relation to neuroradiological (CT and MRI) and surgically verified tumor size, we identified 24 microadenomas, 27 intrasellar macroadenomas, 34 intra-suprasellar macroadenomas, and 36 intra-supra-parasellar macroadenomas. The adenomas were non-infiltrating (76 cases) and infiltrating (45 cases) adenomas. The wall of the cavernous sinus (CS) was infiltrated in 18 cases. Forty-eight adenomas were non-functioning and 73 functioning. The overall mean ± SD Ki-67 LI was 2.72 ± 2.49% (median 1.6). It was 2.59 ± 1.81 in microadenomas, 2.63 ± 3.45 in intrasellar macroadenomas, 1.91 ± 2.11 in intra-suprasellar macroadenomas, and 3.29 ± 5.45 in intra-supra-parasellar macroadenomas (p = 0.27). It was 3.73 ± 5.13% in infiltrating and 2.03 ± 2.41% in non-infiltrating adenomas (p = 0.02), and 5.61 ± 7.19% in CS-infiltrating versus 2.09 ± 2.37% in CS-non-infiltrating adenomas (p = 0.0005).
        
        
          Conclusions
          Our preliminary results seem to exclude significative correlations between Ki-67 LI and tumor size of anterior pituitary adenomas, even if this index can be considered a useful marker in the determination of the infiltrative behaviour of these tumors.

Tags: cell-proliferation, ki-67-labeling-index, nih, pituitary-adenomas, tumor-size
Organization: U.S. Department of Health & Human Services
Chicago: Drug-Related Emergency Department Visits, 2004-2011 - Seeking Detox

Excel file with estimates, rates, relative standard errors, trends and confidence intervals for all drug-related emergency department (ED) visits involving patients seeking detox in the Chicago metropolitan area, covering 2004-2011. This includes nonemergency requests made through the ED for admission to detoxification unit, visits to obtain medical clearance before being incarcerated, and acute emergencies where an individual is experiencing withdrawal symptoms and requests detox. These estimates do not include patients who seek or enter the hospital\'s detox unit through other avenues.

Tags: chicago-metro-area, detoxification-seeking, drug-related-ed-visits, samhsa, substance-use-disorder
Organization: U.S. Department of Health & Human Services
Nevada 2016 Potential Areas for Addressing Service Gaps for Opioid Treatment

The purpose of the medication-assisted treatment (MAT) facility maps is to identify areas on a state-by-state basis that may be potentially underserved by existing treatment facilities. The maps are created with a methodology that seeks to include the highest potential need areas from individual counties so that county-level stakeholders are also informed. The maps are meant to be used as a tool for policy makers to determine potentially underserved areas—not as a definitive representation of these areas.

Tags: medication-assisted-treatment, nevada-health, opioid-treatment, samhsa, service-gap-analysis
Organization: U.S. Department of Health & Human Services
Denver-Aurora-Broomfield, CO

This report presents combined 2005 to 2010 National Survey on Drug Use and Health (NSDUH) results for those aged 12 or older in the Denver-Aurora-Broomfield, CO metro area. The report includes estimates of substance use disorder, major depressive episode, illicit drug use, marijuana use, cigarette use, binge alcohol use, and the nonmedical use of prescription-type pain relievers. Results are provided for the Denver-Aurora-Broomfield metro area, Colorado, and the U.S. overall.

Tags: major-depressive-episode, nsduh-data, samhsa, substance-use-disorder, survey
Organization: U.S. Department of Health & Human Services
A tandem repeats database for bacterial genomes: application to the genotyping of

Background
          Some pathogenic bacteria are genetically very homogeneous, making strain discrimination difficult. In the last few years, tandem repeats have been increasingly recognized as markers of choice for genotyping a number of pathogens. The rapid evolution of these structures appears to contribute to the phenotypic flexibility of pathogens. The availability of whole-genome sequences has opened the way to the systematic evaluation of tandem repeats diversity and application to epidemiological studies.
        
        
          Results
          This report presents a database () of tandem repeats from publicly available bacterial genomes which facilitates the identification and selection of tandem repeats. We illustrate the use of this database by the characterization of minisatellites from two important human pathogens, Yersinia pestis and Bacillus anthracis. In order to avoid simple sequence contingency loci which may be of limited value as epidemiological markers, and to provide genotyping tools amenable to ordinary agarose gel electrophoresis, only tandem repeats with repeat units at least 9 bp long were evaluated. Yersinia pestis contains 64 such minisatellites in which the unit is repeated at least 7 times. An additional collection of 12 loci with at least 6 units, and a high internal conservation were also evaluated. Forty-nine are polymorphic among five Yersinia strains (twenty-five among three Y. pestis strains). Bacillus anthracis contains 30 comparable structures in which the unit is repeated at least 10 times. Half of these tandem repeats show polymorphism among the strains tested.
        
        
          Conclusions
          Analysis of the currently available bacterial genome sequences classifies Bacillus anthracis and Yersinia pestis as having an average (approximately 30 per Mb) density of tandem repeat arrays longer than 100 bp when compared to the other bacterial genomes analysed to date. In both cases, testing a fraction of these sequences for polymorphism was sufficient to quickly develop a set of more than fifteen informative markers, some of which show a very high degree of polymorphism. In one instance, the polymorphism information content index reaches 0.82 with allele length covering a wide size range (600-1950 bp), and nine alleles resolved in the small number of independent Bacillus anthracis strains typed here.

Tags: bacillus-anthracis, bacterial-genomes, nih, tandem-repeats, yersinia-pestis
Organization: U.S. Department of Health & Human Services
Compound 525152: Glycerol-dipropylene glycol ether, triacetate

Chemical compound data from PubChem database. IUPAC Name: 2-[2-(2,3-diacetyloxypropoxy)propoxy]propyl acetate. Molecular Formula: C15H26O8. Molecular Weight: 334.36. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services