AndreaBozzo/ceres-open-data-index huggingface dataset:
22nd European Workshop for Rheumatology Research, Leiden, The Netherlands, 28 February–3 March 2002

The European Workshop for Rheumatology Research met this year in Leiden, The Netherlands. The Workshop provided a platform to feast on new technologies and how they have taken research programmes forward. While there will be the inevitable delay during which mechanisms are devised for analysing the huge amount of information generated by these technologies, there is a lot already to look forward to. Highlights included genomic, reverse genomic and proteomic approaches to understanding disease pathogenesis and to identifying new therapeutic targets. Opportunities for exploring whether pharmacogenomics has a place in the clinic are now a reality, and phage display technology has been applied to in vivo arthritis models to identify human synovial microvascular 'post codes'.

Tags: arthritis-models, genomics-proteomics, nih, rheumatology-research, synovial-microvascular
Organization: U.S. Department of Health & Human Services
Cloning, expression and nuclear localization of human

Background
          Studies suggest that the related proteins nucleoplasmin and nucleophosmin (also called B23, NO38 or numatrin) are nuclear chaperones that mediate the assembly of nucleosomes and ribosomes, respectively, and that these activities are accomplished through the binding of basic proteins via their acidic domains. Recently discovered and less well characterized members of this family of acidic phosphoproteins include mouse nucleophosmin/nucleoplasmin 3 (Npm3) and Xenopus NO29. Here we report the cloning and initial characterization of the human ortholog of Npm3.
        
        
          Results
          Human genomic and cDNA clones of NPM3 were isolated and sequenced. NPM3 lies 5.5 kb upstream of FGF8 and thus maps to chromosome 10q24-26. In addition to amino acid similarities, NPM3 shares many physical characteristics with the nucleophosmin/nucleoplasmin family, including an acidic domain, multiple potential phosphorylation sites and a putative nuclear localization signal. Comparative analyses of 14 members of this family from various metazoans suggest that Xenopus NO29 is a candidate ortholog of human and mouse NPM3, and they further group both proteins closer with the nucleoplasmins than with the nucleophosmins. Northern blot analysis revealed that NPM3 was strongly expressed in all 16 human tissues examined, with especially robust expression in pancreas and testis; lung displayed the lowest level of expression. An analysis of subcellular fractions of NIH3T3 cells expressing epitope-tagged NPM3 revealed that NPM3 protein was localized solely in the nucleus.
        
        
          Conclusions
          Human NPM3 is an abundant and widely expressed protein with primarily nuclear localization. These biological activities, together with its physical relationship to the chaparones nucleoplasmin and nucleophosmin, are consistent with the proposed function of NPM3 as a molecular chaperone functioning in the nucleus.

Tags: gene-expression, nih, nucleophosmin, nucleoplasmin, protein-localization
Organization: U.S. Department of Health & Human Services
Modulation of L-type Ca

Background
          The multisubunit (α1S,α2-δ, β1a and γ1) skeletal muscle dihydropyridine receptor (DHPR) transduces membrane depolarization into release of Ca2+ from the sarcoplasmic reticulum (SR) and also acts as an L-type Ca2+ channel. To more fully investigate the function of the γ1 subunit in these two processes, we produced mice lacking this subunit by gene targeting.
        
        
          Results
          Mice lacking the DHPR γ1 subunit (γ1 null) survive to adulthood, are fertile and have no obvious gross phenotypic abnormalities. The γ1 subunit is expressed at approximately half the normal level in heterozygous mice (γ1 het). The density of the L-type Ca2+ current in γ1 null and γ1 het myotubes was higher than in controls. Inactivation of the Ca2+ current produced by a long depolarization was slower and incomplete in γ1 null and γ1 het myotubes, and was shifted to a more positive potential than in controls. However, the half-activation potential of intramembrane charge movements was not shifted, and the maximum density of the total charge was unchanged. Also, no shift was observed in the voltage-dependence of Ca2+ transients. γ1 null and γ1 het myotubes had the same peak Ca2+ amplitude vs. voltage relationship as control myotubes.
        
        
          Conclusions
          The L-type Ca2+ channel function, but not the SR Ca2+ release triggering function of the skeletal muscle dihydropyridine receptor, is modulated by the γ1 subunit.

Tags: calcium-channel, dihydropyridine-receptor, gene-targeting, muscle-contraction, nih
Organization: U.S. Department of Health & Human Services
Treatment Episode Data Set (TEDS) Highlights - 2006 National Admissions to Substance Abuse Treatment Services

This report presents summary results from the Treatment Episode Data Set (TEDS) for 2006. The report provides information on the demographic and substance abuse characteristics of the 1.8 million people admitted to treatment for abuse of alcohol and drugs that year to facilities that report to individual state administrative data systems.

Tags: alcohol-abuse, drug-abuse, samhsa, substance-abuse, treatment-admissions
Organization: U.S. Department of Health & Human Services
Cost effectiveness in treating ventilator-associated pneumonia

Ventilator-associated pneumonia is a common illness in intensive care unit patients. The costs of management are increased when infection involves resistant organisms, as well as unnecessary and prolonged therapy. Efforts at accurate diagnosis, therapy and prevention can reduce the cost impact of this illness.

Tags: cost-effectiveness-analysis, intensive-care-units, nih, nosocomial-infection, ventilator-associated-pneumonia
Organization: U.S. Department of Health & Human Services
2020 National Mental Health Services Survey (N-MHSS) Annual Report

This report presents findings from the 2020 National Mental Health Services Survey (N-MHSS), an annual census of all known facilities in the United States, both public and private, that provide mental health treatment services to people with mental illness. Planned and directed by the Center for Behavioral Health Statistics and Quality (CBHSQ) of the Substance Abuse and Mental Health Services Administration (SAMHSA), U.S. Department of Health and Human Services, the N-MHSS is designed to collect data on the location, characteristics, and utilization of organized mental health treatment services for facilities within the scope of the survey throughout the 50 states, the District of Columbia, Puerto Rico, and other jurisdictions.

Tags: behavioral-health, mental-health-facilities, mental-health-services, samhsa, treatment-facility-census
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: HHS Regions, Volume 6

These are behavioral health reports for each of the ten HHS regions of the United States. Each report utilizes data from the National Survey on Drug Use and Health (NSDUH), collected annually. The topics addressed in the reports include youth substance use, youth mental health and treatment, adult mental health and treatment, substance use and substance use and treatment.

Tags: behavioral-health, mental-health, nsduh-data, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
2012-2013 NSDUH State Estimates of Substance Use and Mental Disorders

State estimates for 25 measures of substance use and mental disorders based on the combined 2012 and 2013 National Surveys on Drug Use and Health (NSDUHs) are provided. Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Results are provided by State and for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older, and all persons 12 or older. State and cenusus region estimates are based on a small area estimation (SAE) methodology in which State-level NSDUH data are combined with county and census block group/tract-level data from the State.

Tags: mental-disorders, samhsa, small-area-estimation, state-estimates, substance-use
Organization: U.S. Department of Health & Human Services
Table 14. 2011-2012 NSDUH Cigarette Use in the Past Month, by Age Group and State

Table 14. Cigarette Use in the Past Month, by Age Group and State: Percentages, Annual Averages Based on 2011 and 2012 NSDUHs. Results are provided by State and for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: cigarette-use, samhsa, substance-use, tobacco-use, youth-smoking
Organization: U.S. Department of Health & Human Services
Georgia (GA)

This report presents Georgia\'s estimates for 25 measures of substance use and mental health based on the combined 2009 and 2010 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for Georgia for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: georgia-survey, mental-health, nsduh-data, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
2011 State Profile — Nebraska

This is a National Survey of Substance Abuse Treatment Services (N-SSATS) data table showing state profiles for Nebraska in 2011. N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 States, the District of Columbia, and other U.S. jurisdictions.

Tags: n-ssats, nebraska, samhsa, substance-abuse-treatment, treatment-facilities
Organization: U.S. Department of Health & Human Services
Heterogeneous nuclear ribonucleoproteins C1/C2 identified as autoantigens by biochemical and mass spectrometric methods

The antigenic specificity of an unusual antinuclear antibody pattern in three patient sera was identified after separating HeLa-cell nuclear extracts by two-dimensional (2D) gel electrophoresis and localizing the antigens by immunoblotting with patient serum. Protein spots were excised from the 2D gel and their contents were analyzed by matrix-assisted laser desorption-ionization (MALDI) or nanoelectrospray ionization time-of-flight (TOF) tandem mass spectrometry (MS) after in-gel digestion with trypsin. A database search identified the proteins as the C1 and C2 heterogeneous nuclear ribonucleoproteins. The clinical spectrum of patients with these autoantibodies includes arthritis, psoriasis, myositis, and scleroderma. None of 59 patients with rheumatoid arthritis, 19 with polymyositis, 33 with scleroderma, and 10 with psoriatic arthritis had similar antibodies. High-resolution protein-separation methods and mass-spectrometric peptide mapping in combination with database searches are powerful tools in the identification of novel autoantigen specificities.

Tags: arthritis-autoantibodies, autoantibody-specificity, hnrnp-autoantigens, mass-spectrometry-identification, nih
Organization: U.S. Department of Health & Human Services
Measuring access to effective care among elderly medicare enrollees in managed and fee-for-service care: a retrospective cohort study

Background
          Our aim was to compare access to effective care among elderly Medicare patients in a Staff Model and Group Model HMO and in Fee-for-Service (FFS) care.
        
        
          Methods
          We used a retrospective cohort study design, using claims and automated medical record data to compare achievement on quality indicators for elderly Medicare recipients. Secondary data were collected from 1) HMO data sets and 2) Medicare claims files for the time period 1994–95. All subjects were Medicare enrollees in a defined area of New England: those enrolled in two divisions of a managed care plan with different physician payment arrangements: a staff model, and a group model; and the Medicare FFS population. We abstracted information on indicators covering several domains: preventive, diagnosis-specific, and chronic disease care.
        
        
          Results
          On the indicators we created and tested, access in the single managed care plan under study was comparable to or better than FFS care in the same geographic region. Percent of Medicare recipients with breast cancer screening was 36 percentage points higher in the staff model versus FFS (95% confidence interval 34–38 percentage points). Follow up after hospitalization for myocardial infarction was 20 percentage points higher in the group model than in FFS (95% confidence interval 14–26 percentage points).
        
        
          Conclusion
          According to indicators developed for use in both claims and automated medical record data, access to care for elderly Medicare beneficiaries in one large managed care organization was as good as or better than that in FFS care in the same geographic area.

Tags: elderly-health, fee-for-service, managed-care, medicare-enrollees, nih
Organization: U.S. Department of Health & Human Services
Compound 525600: N,N-Dimethyl-N'-(4-methoxyphenyl)-p-methoxybenzamidine

Chemical compound data from PubChem database. IUPAC Name: 4-methoxy-N'-(4-methoxyphenyl)-N,N-dimethylbenzenecarboximidamide. Molecular Formula: C17H20N2O2. Molecular Weight: 284.35. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 528547: Hexadecane, 8-pentyl

Chemical compound data from PubChem database. IUPAC Name: 8-pentylhexadecane. Molecular Formula: C21H44. Molecular Weight: 296.6. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2011 State Profile — New Mexico

This is a National Survey of Substance Abuse Treatment Services (N-SSATS) data table showing state profiles for New Mexico in 2011. N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 States, the District of Columbia, and other U.S. jurisdictions.

Tags: alcohol-abuse, new-mexico, samhsa, substance-abuse-treatment, treatment-facilities
Organization: U.S. Department of Health & Human Services
Analysis of stress- and host cell-induced expression of the

Background
          The gene encoding the inorganic pyrophosphatase (PPase) of the intracellular pathogen Legionella pneumophila is induced during intracellular infection, but is constitutively expressed in Eschericia coli. The causative agent of tuberculosis, Mycobacterium tuberculosis, contains a well conserved copy of PPase. We sought to determine if expression of the M. tuberculosis PPase is regulated by the intracellular environment.
        
        
          Results
          A strain of Mycobacterium bovis bacille Calmette-Guérin (BCG) was constructed in which the Aequoria victoria green fluorescent protein (GFP) is controlled by the promoter of the M. tuberculosis ppa gene. After prolonged exposure of the recombinant BCG strain within murine bone-marrow-derived macrophages, there was no observed increased activity of the ppa promoter. Furthermore, there was no change in promoter activity after exposure to various stress stimuli such as reduced pH, osmotic shock, nutrient limitation or oxidative stress.
        
        
          Conclusions
          These results suggest that macrophage induction of ppa is not a general phenomenon among intracellular pathogens.

Tags: gene-expression, intracellular-infection, mycobacterium-tuberculosis, nih, ppa-promoter
Organization: U.S. Department of Health & Human Services
Publications Using SAMHSA Data8.6 Million Adults Had Suicidal Thoughts in Past Year (2009 to 2010 NSDUH)

This report uses 2009 to 2010 National Survey on Drug Use and Health (NSDUH) to assess past year serious thoughts of suicide among adults aged 18 or older by State.

Tags: adult-mental-health, nsduh-data, samhsa, suicidal-ideation, suicide-prevention
Organization: U.S. Department of Health & Human Services
Instructions to update the SAMHSA SMI and SED Estimates URS Table 1: Number of Adults with Serious Mental Illness, age 18 and older, by State, 2016

These instructions explain how to update the 2016 Substance Abuse and Mental Health Services Administration (SAMHSA) Serious Mental Illness (SMI) and Serious Emotional Disturbances (SED) estimates. This includes obtaining the latest population data by state from the U.S. Census Bureau as well as the calculations and methodology necessary to create updated estimates.

Tags: adult-mental-health, samhsa, serious-mental-illness, smi-estimates, state-level-data
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Illinois, 2014

This is a behavioral health report for the state of Illinois. It uses the National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment Services (NSSATS) to address the topics of youth substance use, youth mental health and treatment, adult mental health and treatment, substance use, and substance use treatment for the years 2009 to 2013.

Tags: illinois-behavioral-health, mental-health-illinois, samhsa, substance-use-trends, youth-mental-health
Organization: U.S. Department of Health & Human Services
Boston: Drug-Related Emergency Department Visits, 2004-2011 - Illicits (excluding alcohol)

Excel file with estimates, rates, relative standard errors, trends and confidence intervals for all drug-related emergency department (ED) visits involving illicit drugs for the Boston metropolitan area, covering 2004-2011. These visits involve the use of drugs that have limited or no therapeutic value and are generally illegal if taken without a prescription. It also includes visits involving the inhalation of substances for their psychoactive properties (e.g., sniffing model airplane glue).

Tags: boston-metro-area, drug-related-ed-visits, emergency-department-data, illicit-drug-use, samhsa
Organization: U.S. Department of Health & Human Services
Compound 525278: Cholestenyl butyrate

Chemical compound data from PubChem database. IUPAC Name: [10,13-dimethyl-17-(6-methylheptan-2-yl)-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] butanoate. Molecular Formula: C31H52O2. Molecular Weight: 456.7. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 527369: 18,22-Dimethyl-tritriacontyl cyanide

Chemical compound data from PubChem database. IUPAC Name: 19,23-dimethyltetratriacontanenitrile. Molecular Formula: C36H71N. Molecular Weight: 518.0. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 525430: 3,3-Dimethyl-4-thiaheptane

Chemical compound data from PubChem database. IUPAC Name: 2-methyl-2-propylsulfanylbutane. Molecular Formula: C8H18S. Molecular Weight: 146.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Research Article: BMC Gastroenterology

Background
          The cytotoxin associated gene A (cagA), and the vacuolating cytotoxin gene A (vacA) of Helicobacter pylori have been associated to phenotypic characteristics of virulence. The objectives of this study were to detect the presence of cagA and to characterize the allelic variants of vacA in 63 strains of H. pylori isolated from colonized individuals with different clinical outcomes.
        
        
          Methods
          38 strains were isolated from patients with non-ulcerative dyspepsia (NUD) and 25 were isolated from colonized individuals with peptic ulcers. The genotypic characterization was carried out utilizing PCR methodology. The presence of the cagA gene was detected using two set of primers from the middle conservative region of the cagA, and primers for the signal and middle region were used for the genotyping of vacA
        
        
          Results
          The presence of cagA showed similar rates in strains from peptic ulcers (60%) and NUD patients (55%). Also similar was the prevalence of the allelic form s1 of vacA between the strains obtained from ulcers or NUD patients. However, the combination cagA+/vacA s1m1 was found more frequently among the H. pylori strains from peptic ulcer patients (52%) than among strains isolated from NUD patients (26%), this difference was statistically significant (p = 0.035).
        
        
          Conclusions
          The presence of either cagA or the allelic variant s1 vacA alone do not have a predictive value as as a risk markers of severe gastric pathologies in the Chilean population. However, being infected by a H. pylori strain with the genotype cagA+/vacA s1m1 may be associated to an increased risk of acquiring a peptic ulcer disease.

Tags: caga-gene, helicobacter-pylori, nih, peptic-ulcer, vaca-gene
Organization: U.S. Department of Health & Human Services