AndreaBozzo/ceres-open-data-index huggingface dataset:
Compound 525195: Chloromethyl 2-chlorononanoate

Chemical compound data from PubChem database. IUPAC Name: chloromethyl 2-chlorononanoate. Molecular Formula: C10H18Cl2O2. Molecular Weight: 241.15. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
National Directory of Drug and Alcohol Abuse Treatment Facilities 2005

The National Directory of Drug and Alcohol Abuse Treatment Programs 2005 lists federal, state, local, and private facilities that provide substance abuse treatment services. The directory includes treatment facilities that are licensed, certified, or otherwise approved for inclusion in the directory by their state substance abuse agencies and that responded to the 2004 National Survey of Substance Abuse Treatment Services (N-SSATS). The information about each facility that appears in this directory was provided by that facility in response to the 2004 N-SSATS. The Substance Abuse and Mental Health Services Administration (SAMHSA) conducts the N-SSATS annually.

Tags: alcohol-abuse, drug-abuse, samhsa, substance-abuse-treatment, treatment-facilities
Organization: U.S. Department of Health & Human Services
Heavy Drinkers Unlikely to Receive Treatment (2002 to 2010 NSDUH)

This report uses 2002 to 2010 National Survey on Drug Use and Health (NSDUH) to assess receipt of past any alcohol use treatment or specialty alcohol use treatment among adults aged 18 or older by alcohol use disorder status

Tags: alcohol-treatment, alcohol-use-disorder, heavy-drinking, samhsa, treatment-gap
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Rhode Island, 2014

This is a behavioral health report for the state of Rhode Island. It uses the  National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment Services (NSSATS) to address the topics of youth substance use , youth mental health and treatment, adult mental health and treatment, substance use, substance use treatment, and medicare enrollees for the years 2009 to 2013.

Tags: behavioral-health, mental-health, rhode-island, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
2012 NSSATS - Data on Substance Abuse Treatment Facilities

This report presents results from the 2012 National Survey of Substance Abuse Treatment Services (N-SSATS), an annual census of facilities providing substance abuse treatment. Conducted by the Substance Abuse and Mental Health Services Administration (SAMHSA), N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 states, the District of Columbia, and other U.S. jurisdictions.

Tags: alcohol-drug-treatment, behavioral-health-services, samhsa, substance-abuse-treatment, treatment-facility-census
Organization: U.S. Department of Health & Human Services
2011 State Profile — North Dakota

This is a National Survey of Substance Abuse Treatment Services (N-SSATS) data table showing state profiles for North Dakota in 2011. N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 States, the District of Columbia, and other U.S. jurisdictions.

Tags: n-ssats, north-dakota, samhsa, substance-abuse-treatment, treatment-facilities
Organization: U.S. Department of Health & Human Services
Gene targeting in mosquito cells: a demonstration of 'knockout' technology in extrachromosomal gene arrays

Background
          Gene targeting would offer a number of advantages over current transposon-based strategies for insect transformation. These include freedom from both position effects associated with quasi-random integration and concerns over transgene instability mediated by endogenous transposases, independence from phylogenetic restrictions on transposon mobility and the ability to generate gene knockouts.
        
        
          Results
          We describe here our initial investigations of gene targeting in the mosquito. The target site was a hygromycin resistance gene, stably maintained as part of an extrachromosomal array. Using a promoter-trap strategy to enrich for targeted events, a neomycin resistance gene was integrated into the target site. This resulted in knockout of hygromycin resistance concurrent with the expression of high levels of neomycin resistance from the resident promoter. PCR amplification of the targeted site generated a product that was specific to the targeted cell line and consistent with precise integration of the neomycin resistance gene into the 5' end of the hygromycin resistance gene. Sequencing of the PCR product and Southern analysis of cellular DNA subsequently confirmed this molecular structure.
        
        
          Conclusions
          These experiments provide the first demonstration of gene targeting in mosquito tissue and show that mosquito cells possess the necessary machinery to bring about precise integration of exogenous sequences through homologous recombination. Further development of these procedures and their extension to chromosomally located targets hold much promise for the exploitation of gene targeting in a wide range of medically and economically important insect species.

Tags: extrachromosomal-arrays, gene-knockout, gene-targeting, mosquito-cells, nih
Organization: U.S. Department of Health & Human Services
Compound 528433: Hexadecane, 4-ethyl

Chemical compound data from PubChem database. IUPAC Name: 4-ethylhexadecane. Molecular Formula: C18H38. Molecular Weight: 254.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Substance Use and Mental Disorders in Metropolitan Areas: Results From the 2005-2010 National Survey on Drug Use and Health

This page presents the metro reports from the combined 2005 to 2010 National Survey on Drug Use and Health (NSDUH) and the data tables that show results for all metro areas. The metro reports include estimates of rates substance use and mental disorders in the United States and in 33 metropolitan areas across nation. Topics covered include substance use disorder, major depressive episode, illicit drug use, marijuana use, cigarette use, binge alcohol use, and the nonmedical use of prescription-type pain relievers. Results are provided by metro area, state, and the U.S. overall.

Tags: mental-health-disorders, metro-area-data, nsduh-survey, samhsa, substance-use-disorder
Organization: U.S. Department of Health & Human Services
CalYOUTH: Proving Extended Foster Care Works for Young Adults in Transition from Foster Care

Since October 1, 2010, title IV-E agencies have the option to provide extended foster care up to age 21. The state of California was an early adopter of this option and also funded the collection of data, research, and an evaluation to understand the implementation and outcomes.

Learn how the state of California has designed and implemented an extended foster care program that improves the lives of young people in transition from foster care.

Presenters:

Co-Hosts:

Audio Description Version

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: child, foster, policy, real, time
Organization: U.S. Department of Health & Human Services
Compound 525621: N,N-Dimethyl-N'-cyclohexyl-p-methylbenzamidine

Chemical compound data from PubChem database. IUPAC Name: N'-cyclohexyl-N,N,4-trimethylbenzenecarboximidamide. Molecular Formula: C16H24N2. Molecular Weight: 244.37. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Table 16. Perceptions of Great Risk of Smoking One or More Packs of Cigarettes per Day among Persons Aged 12 or Older, by State and Substate Regions: Percentages, Annual Averages Based on 2010, 2011, and 2012 NSDUHs

Table 16. Perceptions of Great Risk of Smoking One or More Packs of Cigarettes per Day among Persons Aged 12 or Older, by State and Substate Regions: Percentages, Annual Averages Based on 2010, 2011, and 2012 NSDUHs

Tags: adolescent-health, cigarette-use, nsduh-data, samhsa, smoking-risk-perception
Organization: U.S. Department of Health & Human Services
Patent AT-E400673-T1: [Translated] PRODUCING A HIGH DENSITY THICK CERAMIC FILM BY SCREEN PRINTING

A high density ceramic thick film is fabricated by providing vehicle comprising an organic binder and solvent, dispersing ceramic powders into the vehicle to be paste, forming the paste to thick film by screen printing, removing the organic binder from the film, applying sol or sol-like solution to the surface of the film so that the sol or sol-like solution can infiltrate into the film, removing remaining sol or sol-like solution from the surface of the film, drying and preheating the film, and sintering the film.

Tags: chemistry, innovation, patent, pubchem, research
Organization: U.S. Department of Health & Human Services
Changes in anti-viral effectiveness of interferon after dose reduction in chronic hepatitis c patients: a case control study

Background
          High dose interferon induction treatment of hepatitis C viral infection blocks viral production over 95%. Since dose reduction is often performed due to clinical considerations, the effect of dose reduction on hepatitis C virus kinetics was studied.
        
        
          Methods
          A new model that allowed longitudinal changes in the parameters of viral dynamics was used in a group of genotype-1 patients (N = 15) with dose reduction from 10 to 3 million units of interferon daily in combination with ribavirin, in comparison to a control group (N = 9) with no dose reduction.
        
        
          Results
          Dose reduction gave rise to a complex viral kinetic pattern, which could be only explained by a decrease in interferon effectiveness in blocking virion production. The benefit of the rapid initial viral decline following the high induction dose is lost after dose reduction. In addition, in some patients also the second phase viral decline slope, which is highly predictive of success of treatment, was impaired by the dose reduction resulting in smaller percentage of viral clearance in the dose reduction group.
        
        
          Conclusions
          These findings, while explaining the failure of many induction schedules, suggest that for genotype-1 patients induction therapy should be continued till HCVRNA negativity in serum in order to increase the sustained response rate for chronic hepatitis C.

Tags: dose-reduction, hepatitis-c, interferon-alpha, nih, viral-kinetics
Organization: U.S. Department of Health & Human Services
Compound 525277: N'-Butyl-N,N-dimethyl-acetamidine

Chemical compound data from PubChem database. IUPAC Name: N'-butyl-N,N-dimethylethanimidamide. Molecular Formula: C8H18N2. Molecular Weight: 142.24. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Admissions Reporting Benzodiazepine and Narcotic Pain Reliever Abuse at Treatment Entry

A Treatment Episode Data Set (TEDS) report that provides a unique national perspective of the characteristics associated with people coming to substance abuse treatment with concurrent benzodiazepine and narcotic pain reliever abuse, using data from 2000-2010.

Tags: benzodiazepine-abuse, opioid-abuse, samhsa, substance-abuse-treatment, teds-data
Organization: U.S. Department of Health & Human Services
Title IV-E Tribal Consultation Meetings

Title IV-E Tribal Consultation Meetings
  
  

 (PDF) - This is a request for public comment concerning requirements for transferring children from the placement and care responsibility of a state title IV-E agency to a tribal title IV-E agency and the tribal share of title IV-E administration and training expenditures.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: child, compliance, policy, procedure, scope
Organization: U.S. Department of Health & Human Services
Antithrombin III in patients admitted to intensive care units: a multicenter observational study

Introduction
          The administration of antithrombin III (ATIII) is useful in patients with congenital deficiency, but evidence for the other therapeutic indications of this drug is still uncertain. In Italy, the use of ATIII is very common in intensive care units (ICUs). For this reason we undertook an observational study to determine the pattern of use of ATIII in ICUs and to assess the outcome of patients given this treatment.
        
        
          Methods
          From 20 May to 20 July 2001 all consecutive patients admitted to ICUs in 20 Italian hospitals and treated with ATIII were enrolled. The following information was recorded from each patient: congenital deficiency, indication for use of ATIII, daily dose and duration of ATIII treatment, outcome of hospitalization (alive or dead). The outcome data of our observational study were compared with those reported in previously published randomized controlled trials (RCTs).
        
        
          Results
          Two hundred and sixteen patients were enrolled in the study. The clinical indications for using ATIII were sepsis (25.9%), disseminated intravascular coagulation (23.1%), and other clinical conditions (46.8%). At the end of the study, 65.3% of the patients were alive, 24.5% died and 10.2% were still in the hospital. Among the patients with sepsis (n = 56), 19 died during the observation period (33.9%; 95% confidence interval 22.1–47.5%).
        
        
          Discussion
          Our study described the pattern of use of ATIII in Italian hospitals and provided information on the outcome of the subgroup treated with sepsis. A meta-analysis of current data from RCTs, together with our findings, indicates that there is no sound basis for using this drug in ICU patients with sepsis.

Tags: antithrombin-iii, icu-patients, nih, observational-study, sepsis-treatment
Organization: U.S. Department of Health & Human Services
Myelin contributes to the parallel orientation of axonal growth on white matter

Background
          Brain and spinal cord white matter can support extensive axonal growth. This growth is generally constrained to an orientation that is parallel to the longitudinal axis of the fiber tract. This constraint is presumably due to permissive and non-permissive substrates that are interleaved with each other and oriented in parallel within the tract.
        
        
          Results
          Embryonic chick sympathetic neurons were cultured on cryostat sections of rat brain and the orientation of neurite growth on white matter was assessed. To determine if haptotaxis is sufficient to guide parallel neurite growth, neurons were cultured under conditions designed to interfere with interactions between growing neurites and factors that act as biochemical contact guidance cues but not interactions with haptotactic cues. Under these conditions, neurites extending on white matter were not exclusively oriented in parallel to the fiber tract, suggesting that biochemical cues are involved. To assess the role of myelin in guiding parallel neurite growth, neurons were cultured on myelin-deficient corpus callosum. These neurons also extended neurites that were not constrained to a parallel orientation. Moreover, preincubation with NGF and treatment with cAMP analogs, manipulations that attenuate overall myelin-mediated inhibition of neurite growth, also led to a reduced parallel orientation of neurite growth.
        
        
          Conclusions
          The present studies suggest that some of the relevant factors that constrain axonal growth on white matter are not haptotactic in nature and appear to be partly mediated by factors that are associated with myelin and may involve myelin-associated "inhibitors".

Tags: axonal-growth, myelin, neurite-orientation, nih, white-matter
Organization: U.S. Department of Health & Human Services
Giardiasis in children living in post-earthquake camps from Armenia (Colombia)

Background
          An earthquake in the coffee growing region of Colombia on January 25, 1999 destroyed 70% of the houses in Armenia city. Transitory housing camps still remained until two years after the disaster. Parasitological studies found that, in this population, giardiasis was the most frequent parasitic infection. This study was carried out in order to determine the epidemiological risk factors associated with this high prevalence.
        
        
          Methods
          Fecal samples were obtained from 217 children aged between 3 and 13 years. Stool samples were studied by direct wet examination and stained with ferric hematoxilin for microscopical examination. Epidemiological data were collected by questionnaire and analyzed by using the Epi-info software (CDC, Atlanta 2001).
        
        
          Results
          Giardia cysts were observed in 60.4% of the samples presented and trophozoites in 4.6%. The following epidemiological and laboratory factors were significantly associated with Giardia infection: 1. Use of communal toilet (vs. individual toilet) OR: 3.9, CI95%: 1.2–16; 2. water provision by municipal ducts (vs. water provision by individual tanks) OR: 3.5, CI95% 1.1–14, and 3. presence of mucus in stool OR: 2.3, IC95%: 0.9–6.7.
        
        
          Conclusions
          A high prevalence of giardiasis was found in children living in temporary houses after the 1999 earthquake in Armenia (Colombia). Giardiasis is an emerging disease in post-disaster situations and adequate prevention measures should be implemented during these circumstances.

Tags: giardiasis-infection, nih, parasitic-disease, pediatric-health, post-disaster-health
Organization: U.S. Department of Health & Human Services
The NSDUH Report: Substance Use among Hispanic Adolescents

This report uses 2002 to 2010 National Survey on Drug Use and Health (NSDUH) to assess past month alcohol use, cigarette use, marijuana use, and nonmedical use of prescription-type drugs among Hispanic youth aged 12 to 17. Results are shown for each substance by year, Hispanic subgroups, whether born in the U.S., gender, and, age group.

Tags: hispanic-adolescents, prescription-drug-abuse, samhsa, substance-use, youth-alcohol-marijuana
Organization: U.S. Department of Health & Human Services
Decreased inducibility of TNF expression in lipid-loaded macrophages

Background
          Inflammation and immune responses are considered to be very important in the pathogenesis of atherosclerosis. Lipid accumulation in macrophages of the arterial intima is a characteristic feature of atherosclerosis which can influence the inflammatory potential of macrophages. We studied the effects of lipid loading on the regulation of TNF expression in human monocyte-derived macrophages.
        
        
          Results
          In macrophages incubated with acetylated low density lipoprotein (ac-LDL) for 2 days, mRNA expression of TNF in cells stimulated with TNF decreased by 75%. In cell cultures stimulated over night with IL-1β, lipid loading decreased secretion of TNF into culture medium by 48%. These results suggest that lipid accumulation in macrophages makes them less responsive to inflammatory stimuli. Decreased basal activity and inducibility of transcription factor AP-1 was observed in lipid-loaded cells, suggesting a mechanism for the suppression of cytokine expression. NF-κB binding activity and inducibility were only marginally affected by ac-LDL. LDL and ac-LDL did not activate PPARγ. In contrast, oxidized LDL stimulated AP-1 and PPARγ but inhibited NF-κB, indicating that the effects of lipid loading with ac-LDL were not due to oxidation of lipids.
        
        
          Conclusions
          Accumulation of lipid, mainly cholesterol, results in down-regulation of TNF expression in macrophages. Since monocytes are known to be activated by cell adhesion, these results suggest that foam cells in atherosclerotic plaques may contribute less potently to an inflammatory reaction than newly arrived monocytes/macrophages.

Tags: acetylated-ldl, atherosclerosis-inflammation, lipid-loaded-macrophages, macrophage-tnf-expression, nih
Organization: U.S. Department of Health & Human Services
Oral sildenafil (Viagra™) in male erectile dysfunction: use, efficacy and safety profile in an unselected cohort presenting to a British district general hospital.

Introduction
          Sildenafil (Viagra®) is one of the drugs used in the first line therapy of male erectile dysfunction (MED). We have recorded outcomes, adverse events and acceptability of Sildenafil (Viagra) therapy in an unselected group of men presenting with ED to a British district general hospital.
        
        
          Methods
          In this prospective observational study, 147 men with ED were seen since Oct 1999. Study patients were reviewed at 4, 12 and 52 weeks. All the patients filled the International Index of Erectile Function (IIEF) questionnaire and were asked about their willingness to pay (WTP) for treatment.
        
        
          Results
          All suitable men accepted Viagra as first line therapy. 91% of our patients found sildenafil treatment successful. 80% of these patients were willing to continue with sildenafil therapy. Side effect profile of sildenafil was different in this study with much higher incidence of headache, dyspepsia, flushing and abnormal vision. 92% of men with ED expect to be treated by the NHS. Of those men eligible for treatment in the NHS, 30% qualify under the clinical categories and 18% under the 'distress' category. Only 55% of those with cardiovascular risk factors qualify for NHS treatment.
        
        
          Conclusions
          Sildenafil is widely accepted as first line therapy among British men with ED and has a success rate of 91%. Nearly half of men with ED qualify for NHS treatment. Nearly half of those with vascular risk factors do not qualify for NHS treatment. Most men with ED could possibly be managed in primary care.

Tags: erectile-dysfunction, iief-questionnaire, nih, sildenafil-viagra, treatment-outcomes
Organization: U.S. Department of Health & Human Services
MedlinePlus Connect for Electronic Health Record (EHR) Systems - Web Service

<p>A Web service that allows patient portals and electronic health record (EHR) systems to use existing code sets to link to relevant, authoritative health information from MedlinePlus.gov. Matches ICD-9-CM or SNOMED CT codes to related MedlinePlus consumer health information, LOINC codes to information on lab tests, and also matches NDC, RXCUI or text strings to patient medication information.</p>

Tags: biomedical-research, connect, ehr, ehrs, electronic-health-records, electronic-medical-records, emr, emrs, health, health-services, icd-9, infobutton, loinc, medicine, medlineplus, ndc, patient-education, patient-health-records, phr, phrs, rxnorm, snomed-ct, wellness
Organization: U.S. Department of Health & Human Services