AndreaBozzo/ceres-open-data-index huggingface dataset:
Elevated antibody to D-alanyl lipoteichoic acid indicates caries experience associated with fluoride and gingival health

Background
          Acidogenic, acid-tolerant bacteria induce dental caries and require D-alanyl glycerol lipoteichoic acid (D-alanyl LTA) on their cell surface. Because fluoride inhibits acid-mediated enamel demineralization, an elevated antibody response to D-alanyl LTA may indicate subjects with more acidogenic bacteria and, therefore, an association of DMFT with fluoride exposure and gingival health not apparent in low responders.
        
        
          Methods
          Cluster analysis was used to identify low antibody content. Within low and high responders (control and test subjects), the number of teeth that were decayed missing and filled (DMFT), or decayed only (DT) were regressed against fluoride exposure in the water supply and from dentrifice use. The latter was determined from gingival health: prevalences of plaque (PL) and bleeding on probing (BOP), and mean pocket depth (PD). Age was measured as a possible confounding cofactor.
        
        
          Results
          In 35 high responders, DMFT associated with length of exposure to fluoridated water (F score), PL and BOP (R2 = 0.51, p < 0.001), whereas in 67 low D-ala-IgG responders, DMFT associated with PL, age, and PD (R2 = 0.26, p < 0.001). BOP correlated strongly with number of 7 7 decayed teeth (DT) in 54 high responders (R2 = 0.57, p < 0.001), but poorly in 97 low responders (R2 = 0.12, p < 0.001). The strength of the PD association with DMFT, or of BOP with DT, in high responders significantly differed from that in low responders (p < 0.05).
        
        
          Conclusion
          Caries associates with gingival health and fluoridated water exposure in high D-alanyl LTA antibody responders.

Tags: d-alanyl-lta, dental-caries, fluoride-exposure, gingival-health, nih
Organization: U.S. Department of Health & Human Services
Compound 528454: 1-Nonene, 5-methyl

Chemical compound data from PubChem database. IUPAC Name: 5-methylnon-1-ene. Molecular Formula: C10H20. Molecular Weight: 140.27. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Supporting Evidence-Based Home Visitation Programs to Prevent Child Abuse and Neglect Project: Rochester Society for the Prevention and Cruelty to Children

Location:

Monroe County (Rochester)

Home Visiting Program Selected:

Nurse Family Partnership; Parents as Teachers

Home Visiting Target Population:

At-risk, low-income parents who had their first child below age 21

Project Overview:
The Rochester Society for the Prevention of Cruelty to Children will collaborate with seven community partners to examine the benefits of combining multiple evidence-based home visitation and other models to effectively meet the needs of families at the greatest risk, with the goal of reducing child maltreatment and enhancing family functioning. Depending on eligibility, families will receive Nurse Family Partnership or other evidence-base programs, including Parents as Teachers. During intake, families will participate in a comprehensive screening process that identifies whether the family needs more intense mental health therapy. A rigorous evaluation will compare treatment delivery through a multi-tiered evidence-based service delivery model that includes Nurse Family Partnership services. Program participants will first be screened for Nurse Family Partnership eligibility. If ineligible, they will then be randomly assigned to alternative evidence-based home visitation services or to an enhanced treatment as usual group that includes only referrals to community resources. To support their building a sustainable infrastructure, a Steering Committee will explore leveraging of funding streams and develop a model capable of national replication for sustainability.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: abuse, home, intervention, neglect, prevention
Organization: U.S. Department of Health & Human Services
Research Article: BMC Genetics

Background
          Blood group genotyping is increasingly utilized for prenatal diagnosis and after recent transfusions, but still lacks the specificity of serology. In whites, the presence of antigen D is predicted, if two or more properly selected RHD-specific polymorphism are detected. This prediction must fail, if an antigen D negative RHD positive allele is encountered. Excluding RHDψ and CdeS frequent only in individuals of African descent, most of these alleles are unknown and the population frequency of any such allele has not been determined.
        
        
          Methods
          We screened 8,442 antigen D negative blood donations by RHD PCR-SSP. RHD PCR positive samples were further characterized by RHD exon specific PCR-SSP or sequencing. The phenotype of the identified alleles was checked and their frequencies in Germans were determined.
        
        
          Results
          We detected 50 RHD positive samples. Fifteen samples harbored one of three new Del alleles. Thirty samples were due to 14 different D negative alleles, only 5 of which were previously known. Nine of the 14 alleles may have been generated by gene conversion in cis, for which we proposed a mechanism triggered by hairpin formation of chromosomal DNA. The cumulative population frequency of the 14 D negative alleles was 1:1,500. Five samples represented a D+/- chimera, a weak D and three partial D, which had been missed by routine serology; two recipients transfused with blood of the D+/- chimera donor became anti-D immunized.
        
        
          Conclusion
          The results of this study allowed to devise an improved RHD genotyping strategy, the false-positive rate of which was lower than 1:10,000. The number of characterized RHD positive antigen D negative and Del alleles was more than doubled and their population frequencies in Europe were defined.

Tags: blood-group-antigens, nih, prenatal-diagnosis, rhd-alleles, rhd-genotyping
Organization: U.S. Department of Health & Human Services
LDL-cholesterol lowering effect of a generic product of simvastatin compared to simvastatin (Zocor™) in Thai hypercholesterolemic subjects – a randomized crossover study, the first report from Thailand

Background
          It is commonly agreed that people with a high blood LDL-cholesterol will have a higher risk of coronary artery disease (CAD) than people with low blood LDL-cholesterol. Due to the increasingly high costs of medication in Thailand, the government has set up several measures to combat the problem. One of such strategies is to promote the utilization of locally manufactured drug products, especially those contained in the National Drug List. Simvastatin, an HMG-CoA reductase inhibitor, is listed as an essential drug for the treatment of hypercholesterolemia. Here, we reported the study on the LDL-cholesterol-lowering effect of a generic simvastatin product in comparison with the Zocor©, in 43 healthy thai  volunteers.
        
        
          Method
          The generic product tested  was Eucor©, locally manufactured by Greater Pharma Ltd., Part, Thailand, and the reference product was Zocor© (Merck Sharp & Dohme, USA). The two products were administered as 10-mg single oral doses in a two-period crossover design. After drug administration, serial blood samples were collected every 4 weeks for 16 weeks. The major parameter monitored in this study was blood LDL-cholesterol.
        
        
          Result
          After taking the drugs for the first 8 weeks, no statistically significant difference was dedected in blood LDL-cholesterol between the first (Zocor©-treated) and the second (Eucor©-treated) groups. After crossover and taking drugs for further 8 weeks, a similar result was obtained, i.e., no significant difference in blood LDL-cholesterol between the first (Eucor©-treated) and the second (Zocor©-treated) groups was observed. Upon completion of the 16-week study, there was also no statisticaly significant difference in the changes of all tested blood parameters between the two products (randomized block ANOVA, N = 37). Only minor side effects, mainly dizziness and nausea, were observed in both products.
        
        
          Conclusion
          Our study demonstrated no significant differences in the therapeutic effect and safety between the generic and original simvastatin products.

Tags: hypercholesterolemia-treatment, ldl-cholesterol, nih, simvastatin-efficacy, thai-population
Organization: U.S. Department of Health & Human Services
Collaborative interactions between neutrophil elastase and metalloproteinases in extracellular matrix degradation in three-dimensional collagen gels

Background
          Extended culture of monocytes and fibroblasts in three-dimensional collagen gels leads to degradation of the gels (see linked study in this issue, "Fibroblasts and monocytes contract and degrade three-dimensional collagen gels in extended co-culture"). The current study, therefore, was designed to evaluate production of matrix-degrading metalloproteinases by these cells in co-culture and to determine if neutrophil elastase could collaborate in the activation of these enzymes. Since co-cultures produce prostaglandin E2 (PGE2), the role of PGE2 in this process was also evaluated.
        
        
          Methods
          Blood monocytes from healthy donors and human fetal lung fibroblasts were cast into type I collagen gels and maintained in floating cultures for three weeks. Matrix metalloproteinases (MMPs) were assessed by gelatin zymography (MMPs 2 and 9) and immunoblotting (MMPs 1 and 3). The role of PGE2 was explored by direct quantification, and by the addition of exogenous indomethacin and/or PGE2.
        
        
          Results
          Gelatin zymography and immunoblots revealed that MMPs 1, 2, 3 and 9 were induced by co-cultures of fibroblasts and monocytes. Neutrophil elastase added to the medium resulted in marked conversion of latent MMPs to lower molecular weight forms consistent with active MMPs, and was associated with augmentation of both contraction and degradation  (P < 0.01). PGE2 appeared to decrease both MMP production and activation.
        
        
          Conclusion
          The current study demonstrates that interactions between monocytes and fibroblasts can mediate tissue remodeling.

Tags: collagen-degradation, lung-fibroblasts, matrix-metalloproteinases, neutrophil-elastase, nih
Organization: U.S. Department of Health & Human Services
Compound 525170: Nonaethylene glycol, diacetate

Chemical compound data from PubChem database. IUPAC Name: 2-[2-[2-[2-[2-[2-[2-[2-(2-acetyloxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl acetate. Molecular Formula: C22H42O12. Molecular Weight: 498.6. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2019 Uniform Reporting System (URS) Table for Guam

These are the 2019 Uniform Reporting System (URS) Output Tables for Guam. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, guam-mental-health, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Compound 525672: p-Bromobenzylidene-octyl-amine

Chemical compound data from PubChem database. IUPAC Name: 1-(4-bromophenyl)-N-octylmethanimine. Molecular Formula: C15H22BrN. Molecular Weight: 296.25. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Approaches to enhancing the retroviral transduction of human synoviocytes

This report concerns a clinical trial for rheumatoid arthritis (RA), approved by the US National Institutes of Health and the Food and Drug Administration. An amphotropic retrovirus (MFG-IRAP) was used ex vivo to transfer a cDNA encoding human interleukin-1 receptor antagonist (IL-1Ra) to synovium. The protocol required the transduced cells to secrete at least 30 ng IL-1Ra/106 cells per 48 h before reimplantation. Here we have evaluated various protocols for their efficiency in transducing cultures of human rheumatoid synoviocytes. The most reliably efficient methods used high titer retrovirus (approximately 108 infectious particles/ml). Transduction efficiency was increased further by exposing the cells to virus under flow-through conditions. The use of dioctadecylamidoglycylspermine (DOGS) as a polycation instead of Polybrene (hexadimethrine bromide) provided an additional small increment in efficiency. Under normal conditions of static transduction, standard titer, clinical grade retrovirus (approximately 5 × 105 infectious particles/ml) failed to achieve the expression levels required by the clinical trial. However, the shortfall could be remedied by increasing the time of transduction under static conditions, transducing under flow-through conditions, or transducing during centrifugation.

Tags: gene-therapy, il-1ra, nih, rheumatoid-arthritis, synoviocytes
Organization: U.S. Department of Health & Human Services
Lack of agreement between tonometric and gastric juice partial carbon dioxide tension

Our goal was to compare measurement of tonometered saline and gastric juice partial carbon dioxide tension (PCO2). In this prospective observational study, 112 pairs of measurements were simultaneously obtained under various hemodynamic conditions, in 15 critical care patients. Linear regression analysis showed a significant correlation between the two methods of measuring PCO2 (r 2 = 0.43; P < 0.0001). However, gastric juice PCO2 was systematically higher (mean difference 51 mmHg). The 95% limits of agreement were 315 mmHg and the dispersion increased as the values of PCO2 increased. Tonometric and gastric juice PCO2 cannot be used interchangeably. Gastric juice PCO2 measurement should be interpreted with caution.

Tags: acid-base-balance, critical-care, gastric-tonometry, nih, pco2-measurement
Organization: U.S. Department of Health & Human Services
2013-2014 NSDUH National Maps of Prevalence Estimates by State

National maps presented here show estimates from the 2013-2014 National Surveys on Drug Use and Health (NSDUH) for 25 substance use and mental health outcomes, by age group, for 50 States and the District of Columbia. The color of each State indicates how a State ranks relative to other States for each measure. States with the highest rates for a given measure are in red, with the exception of the perceptions of great risk measures, for which the lowest perceptions of great risk are in red. Those States with the lowest estimates are in white, with the exception of the perceptions of great risk measures, for which the highest perceptions of great risk are in white.

Tags: mental-health, nsduh-data, samhsa, state-prevalence, substance-use
Organization: U.S. Department of Health & Human Services
2016 Uniform Reporting System (URS) Table for Virginia

This is the 2016 Uniform Reporting System (URS) Output Tables for Virginia. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, national-outcome-measures, samhsa, urs-data
Organization: U.S. Department of Health & Human Services
Substance Abuse Facilities with Services in Spanish Are Available in All Regions for Hispanic Clients Admitted to Treatment in 2010

This National Survey on Substance Abuse Treatment Services (NSSATS) Data Spotlight presents a regional snapshot of the percentage of facilities that reported providing services in Spanish and of the Hispanic clients admitted in 2011.

Tags: hispanic-clients, nssats, samhsa, spanish-language-services, substance-abuse-treatment
Organization: U.S. Department of Health & Human Services
Research Article: BMC Immunology

Background
          Peroxynitrite is increasingly proposed as a contributor to defence system in marine bivalve. It can be formed by combinaison of superoxide and nitric oxide, and can react with tyrosine residues of proteins giving rise to 3-nitrotyrosine.
        
        
          Results
          The present article describes a competitive ELISA for the measurement of 3-nitrotyrosine contents of plasma proteins from marine bivalves by means of a monoclonal anti 3-nitrotyrosine antibody mouse IgG.
        
        
          Conclusions
          This assay is sensitive enough to determine the amounts of 3-nitrotyrosine in plasma proteins from one animal only.
          Using the C-ELISA, we have shown that the phagocytosis of zymosan particles increased the 3-nitrotyrosine levels of plasma proteins from mussel M. galloprovincialis and oyster C. gigas 5.8 and 7.5 times respectively.

Tags: 3-nitrotyrosine, competitive-elisa, immunology, marine-bivalves, nih
Organization: U.S. Department of Health & Human Services
2020 Uniform Reporting System (URS) Table For Maine

This is the 2020 Uniform Reporting System (URS) Output Tables for Maine. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-program, mental-health-services, national-outcome-measures, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
2013 CMHS Uniform Reporting System (URS) Table for Republic of Palau

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Tables for Republic of Palau for 2013. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program.  State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, national-outcome-measures, palau, samhsa
Organization: U.S. Department of Health & Human Services
'Bath Salts' Were Involved in over 20,000 Drug-Related Emergency Department Visits in 2011

This report is about ER visits involving 'bath salts,' a new type of stimulant drug, and describes what types of drugs are most commonly combined with 'bath salts' in ER visits.

Tags: bath-salts, drug-overdose, emergency-department, samhsa, stimulant-drugs
Organization: U.S. Department of Health & Human Services
Reviewing the reviewers: the vague accountability of research ethics committees

The role of research ethics committees (RECs) is currently strained by increases in the number of protocols that are in need of review, the scientific and funding complexities of the protocols, and a lack of clear standards for ethics assessment. This commentary describes the significance of these strains and calls for clarification of reviewer accountability. To maintain or, in many cases, to restore public and professional trust in the ethics of human research and in REC review of protocols, it is imperative that steps be taken to clarify the accountability of RECs and their individual members.

Tags: ethics-committee, institutional-review-board, nih, research-accountability, research-ethics
Organization: U.S. Department of Health & Human Services
Compound 527377: 20,24-Dimethyl-tritriacontyl cyanide

Chemical compound data from PubChem database. IUPAC Name: 21,25-dimethyltetratriacontanenitrile. Molecular Formula: C36H71N. Molecular Weight: 518.0. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
A draft annotation and overview of the human genome

Background
          The recent draft assembly of the human genome provides a unified basis for describing genomic structure and function. The draft is sufficiently accurate to provide useful annotation, enabling direct observations of previously inferred biological phenomena.
        
        
          Results
          We report here a functionally annotated human gene index placed directly on the genome. The index is based on the integration of public transcript, protein, and mapping information, supplemented with computational prediction. We describe numerous global features of the genome and examine the relationship of various genetic maps with the assembly. In addition, initial sequence analysis reveals highly ordered chromosomal landscapes associated with paralogous gene clusters and distinct functional compartments. Finally, these annotation data were synthesized to produce observations of gene density and number that accord well with historical estimates. Such a global approach had previously been described only for chromosomes 21 and 22, which together account for 2.2% of the genome.
        
        
          Conclusions
          We estimate that the genome contains 65,000-75,000 transcriptional units, with exon sequences comprising 4%. The creation of a comprehensive gene index requires the synthesis of all available computational and experimental evidence.

Tags: gene-annotation, gene-mapping, genomic-structure, human-genome, nih
Organization: U.S. Department of Health & Human Services
Compound 525189: Tripropylene glycol, monoallyl ether, acetate

Chemical compound data from PubChem database. IUPAC Name: 1-[1-(1-prop-2-enoxypropan-2-yloxy)propan-2-yloxy]propan-2-yl acetate. Molecular Formula: C14H26O5. Molecular Weight: 274.35. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Managing a Hybrid Agile Project: Roundtable With Delaware’s FOCUS Project Leadership

Delaware’s FOCUS project uses a hybrid Agile approach that incorporates Agile practices while keeping within the parameters of typical fixed-scope projects. The FOCUS project is driven by engaged stakeholders, a consistent emphasis on scope, and disciplined monitoring of plans and progress.

Join leadership staff of the FOCUS project as they discuss their successes and challenges. They will speak about their Agile approaches for software development and describe their best practices for project management as well as for monitoring impediments and risks. They will also answer questions from participants. Speakers include the following:

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: agile, metadata, policy, project, scope
Organization: U.S. Department of Health & Human Services