AndreaBozzo/ceres-open-data-index huggingface dataset:
Alterations induced by chronic stress in lymphocyte subsets of blood and primary and secondary immune organs of mice

Background
          The immune system is particularly sensitive to stress. Although acute stress generally has positive effects, chronic stress typically provokes immunosuppression. The elucidation of the mechanisms involved in immunosuppression are of interest for the design of therapeutic approaches to avoid the appearance of stress disorders. This study aimed to investigate chronic stress-induced alterations on lymphocyte subset distribution and percentages. The experiments were performed with C57BL/6 mice subjected to chronic immobilization stress.
        
        
          Results
          Stress caused a marked increase in apoptosis inside the thymus, and a reduction in the total number of thymocytes. Furthermore, the proportion of immature thymocytes declined significantly suggesting that the increased apoptosis mainly affected cells of immature phenotype. In blood, the total number of lymphocytes diminished but not all lymphocyte populations showed the same tendency: while the relative proportion of B cells declined slightly, the relative proportion of circulating CD3+ cells, and particularly some T cell subsets showing an immature phenotype (CD3+PNA+), increased under stress. The spleen and lymph nodes show a marked reduction in cellularity, but the relative proportion of T cells increased, while no change or only a slight reduction was observed in the relative proportion of B cells. Similarly, the relative proportion of T cells increased in bone marrow.
        
        
          Conclusions
          Detailed data on the alterations of lymphoid cell subsets occurring under immobilization stress, both in the bloodstream and in different lymphoid tissues, are obtained. In general, T cells are more affected than B cells and, in particular, a marked increase in the percentage of a subset of circulating PNA+CD3+ T cells is observed.

Tags: chronic-stress, immunosuppression, lymphocyte-subsets, mouse-immunology, nih
Organization: U.S. Department of Health & Human Services
2010 State Profile — Mississippi

This state profile includes data from facilities in Mississippi that reported to N-SSATS for the survey reference date March 31, 2010. Data were collected on the location, characteristics, services offered, and number of clients in treatment at alcohol and drug abuse treatment facilities (both public and private) in Mississippi. In Mississippi, 102 substance abuse treatment facilities were included in the 2010 N-SSATS, reporting that there were 5,037 clients in substance abuse treatment on March 31, 2010. The survey response rate in Mississippi was 96.3%.

Tags: alcohol-drug-abuse, mississippi, n-ssats, samhsa, substance-abuse-treatment
Organization: U.S. Department of Health & Human Services
2021-2022 NSDUH: Model-Based Estimated Prevalence for States

Browse state-level percentage estimates based on the 2021-2022 National Surveys on Drug Use and Health (NSDUH). The 37 tables include estimates for 35 measures of substance use and mental health, by age group, along with 95% confidence intervals. The percentages are based on small area estimation (SAE) methods, in which state-level NSDUH data are combined with other data from smaller geographies. The combined data are used to create modeled state estimates of the civilian, noninstitutionalized population ages 12 and older, or adults 18 and older for mental health measures. Each table covers a single measure by state, region, and age group.The indicators are presented in the following 37 tables:Drug use and Perceived RiskIllicit Drug Use in the Past MonthMarijuana Use in the Past YearMarijuana Use in the Past MonthPerceptions of Great Risk from Smoking Marijuana Once a MonthFirst Use of Marijuana in the Past Year (among those at risk for initiation)Illicit Drug Use Other than Marijuana in the Past MonthCocaine Use in the Past YearPerceptions of Great Risk from using Cocaine Once a MonthHeroin Use in the Past YearPerceptions of Great Risk from Trying Heroin Once or TwiceHallucinogen Use in the Past YearMethamphetamine Use in the Past YearPrescription Pain Reliever Misuse in the Past YearOpioid Misuse in the Past YearAlcoholAlcohol Use in the Past MonthBinge Alcohol Use in the Past MonthPerceptions of Great Risk from Having Five or More Drinks of an Alcoholic Beverage Once or Twice a WeekAlcohol Use, Binge Alcohol Use in the Past Month, and Perceptions of Great Risk from Having Five or More Drinks of an Alcoholic Beverage Once or Twice a Week (among people aged 12 to 20)TobaccoTobacco Product Use in the Past MonthCigarette Use in the Past MonthPerceptions of Great Risk from Smoking One or More Packs of Cigarettes per DaySubstance Use DisordersSubstance Use Disorder in the Past YearAlcohol Use Disorder in the Past YearAlcohol Use Disorder in the Past Year (among people aged 12 to 20)Drug Use Disorder in the Past YearPain Reliever Use Disorder in the Past YearOpioid Use Disorder in the Past YearSubstance Use TreatmentReceived Substance Use Treatment in the Past YearClassified as Needing Substance Use Treatment in the Past YearDid Not Receive Substance Use Treatment in the Past Year among those Classified as Needing Substance Use TreatmentMental IllnessAny Mental Illness in the Past YearSerious Mental Illness in the Past YearReceived Mental Health Treatment in the Past YearMajor Depressive Episode in the Past YearSuicidalityHad Serious Thoughts of Suicide in the Past YearMade Any Suicide Plans in the Past YearAttempted Suicide in the Past YearThe tables are available in an Excel spreadsheet, a PDF file, or as a zip file of 37 CSV text files.

Tags: mental-health, nsduh-data, samhsa, state-prevalence, substance-use
Organization: U.S. Department of Health & Human Services
2019 Uniform Reporting System (URS) Table for Wyoming

These are the 2019 Uniform Reporting System (URS) Output Tables for Wyoming. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant, mental-health-services, national-outcome-measures, samhsa, wyoming
Organization: U.S. Department of Health & Human Services
2013 CMHS Uniform Reporting System (URS) Table for Rhode Island

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Tables for Rhode Island for 2013. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program.  State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, noms-measures, rhode-island, samhsa
Organization: U.S. Department of Health & Human Services
Compound 525591: N,N-Dimethyl-N'-(4-chlorophenyl)-p-chlorobenzamidine

Chemical compound data from PubChem database. IUPAC Name: 4-chloro-N'-(4-chlorophenyl)-N,N-dimethylbenzenecarboximidamide. Molecular Formula: C15H14Cl2N2. Molecular Weight: 293.2. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Dr. Elinore F. McCance-Katz, Webcast slides, National Survey on Drug Use and Health (NSDUH): 2017

View therecorded presentation(link is external)of the NSDUH data and webcast slides (PDF,PPTX) presented by Dr. Elinore F. McCance-Katz.

Tags: behavioral-health, mental-health, nsduh-2017, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Nebraska (NE)

This report presents Nebraska\'s estimates for 25 measures of substance use and mental health based on the combined 2009 and 2010 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for Nebraska for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: mental-health, nebraska, nsduh-data, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
2013 CMHS Uniform Reporting System (URS) Table for South Dakota

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Tables for South Dakota for 2013. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program.  State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant, mental-health-services, outcome-measures, samhsa, south-dakota
Organization: U.S. Department of Health & Human Services
2019 Uniform Reporting System (URS) Table for New Mexico

These are the 2019 Uniform Reporting System (URS) Output Tables for New Mexico. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: behavioral-health, mental-health-services, noms-measures, samhsa, urs-data
Organization: U.S. Department of Health & Human Services
Chicago: Drug-Related Emergency Department Visits, 2004-2011 - All Misuse and Abuse

Excel file with estimates, rates, relative standard errors, trends and confidence intervals for all drug-related emergency department (ED) visits involving drug misuse or abuse in the Chicago metropolitan area, covering 2004-2011. Drug misuse/abuse visits include the use of illicit drugs, nonmedical use of pharmaceuticals, underage drinking and visits where alcohol was combined with another drug.

Tags: chicago-metro-area, drug-related-ed-visits, emergency-department, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
Smoking and Mental Illness Among Adults in the United States

This report uses 2012 to 2014 National Survey on Drug Use and Health (NSDUH) data to percentages of past month cigarette use, average number of cigarettes smoked in the past month, prevalence of smoking cessation among adults with past year mental illness in comparison to adults with no past year mental illness.

Tags: adult-health, cigarette-use, mental-illness, samhsa, smoking-cessation
Organization: U.S. Department of Health & Human Services
Macrofilaricides and onchocerciasis control, mathematical modelling of the prospects for elimination

Background
          In most endemic parts of the world, onchocerciasis (river blindness) control relies, or will soon rely, exclusively on mass treatment with the microfilaricide ivermectin. Worldwide eradication of the parasite by means of this drug is unlikely. Macrofilaricidal drugs are currently being developed for human use.
        
        
          Methods
          We used ONCHOSIM, a microsimulation mathematical model of the dynamics of onchocerciasis transmission, to explore the potentials of a hypothetical macrofilaricidal drug for the elimination of onchocerciasis under different epidemiological conditions, as characterized by previous intervention strategies, vectorial capacity and levels of coverage.
        
        
          Results
          With a high vector biting rate and poor coverage, a very effective macrofilaricide would appear to have a substantially higher potential for achieving elimination of the parasite than does ivermectin.
        
        
          Conclusions
          Macrofilaricides have a substantially higher potential for achieving onchocerciasis elimination than ivermectin, but high coverage levels are still key. When these drugs become available, onchocerciasis elimination strategies should be reconsidered. In view of the impact of control efforts preceding the introduction of macrofilaricides on the success of elimination, it is important to sustain current control efforts.

Tags: ivermectin-treatment, macrofilaricidal-drugs, mathematical-modeling, nih, onchocerciasis-control
Organization: U.S. Department of Health & Human Services
Compound 525217: Chloromethyl 6-chlorohexanoate

Chemical compound data from PubChem database. IUPAC Name: chloromethyl 6-chlorohexanoate. Molecular Formula: C7H12Cl2O2. Molecular Weight: 199.07. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Richness of Colchic vegetation: comparison between refugia of south-western and East Asia

Background
          The Colchis is one of the species-rich refugia and a centre of biological diversity in western Eurasia. We analysed patterns of richness, endemism and invasions in relation to taxonomy (family membership), life form, certain habitats in the Colchis, and compared them to patterns found for Japan.
        
        
          Results
          We found that in the Colchis perennials are significantly over-represented in endemic species, and that they typically occur on limestone soils and in alpine tall herbaceous vegetation. The Asteraceae produce significantly large number of both endemic and alien species, whereas the Poaceae are over-represented in alien species but under-represented in endemics. Likewise, the Apiaceae are over-represented in endemics, whereas the Euphorbiaceae are over-represented in alien species. Similar patterns have been found in Yakushima, Japan. The Morisita-Horn index of similarity between these two sites was 0.83 (based on family size). Although the flora of Adjara comprised of fewer families than the flora of Yakushima, the largest families are richer in species in the flora of Adjara than in the flora of Yakushima.
        
        
          Conclusions
          Floristic analysis of refugia of western Eurasia and their comparison with geographically distant areas can provide useful data for plant ecological and evolutionary studies. Potentially, such studies can produce testable hypotheses on plant migrations and on their historical geography. For example, the data presented in this study indicate that more severe conditions in the Pleistocene and geographical isolation of the Colchis may be responsible for the higher relative importance of adaptive radiation in the shaping of its modern flora.

Tags: colchis-flora, endemism-patterns, nih, species-richness, vegetation-analysis
Organization: U.S. Department of Health & Human Services
2020 Uniform Reporting System (URS) Table For Alabama

This is the 2020 Uniform Reporting System (URS) Output Tables for Alabama. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-program, mental-health-services, national-outcome-measures, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
Compound 525102: 1,3-Dichloroisopropyl pentanoate

Chemical compound data from PubChem database. IUPAC Name: 1,2-dichloropropan-2-yl pentanoate. Molecular Formula: C8H14Cl2O2. Molecular Weight: 213.1. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
National Survey of Substance Abuse Treatment Services: State Profiles 2006

The 2006 National Survey of Substance Abuse Treatment Services (N-SSATS) is an annual survey of facilities providing substance abuse treatment. The N-SSATS, conducted by the Substance Abuse and Mental Health Services Administration (SAMHSA), is designed to collect data on the location, characteristics, services offered, and number of clients in treatment at alcohol and drug abuse facilities (both public and private) throughout the 50 states, the District of Columbia, and other U.S. jurisdictions.

Tags: alcohol-drug-abuse, n-ssats, samhsa, substance-abuse-treatment, treatment-facilities
Organization: U.S. Department of Health & Human Services
The NSDUH Report: Major Depressive Episode among Full-Time College Students and Other Young Adults, Aged 18 to 22

This issue of the National Survey on Drug Use and Health (NSDUH) Report presents combined 2008 to 2010 data to examine the prevalence of past year major depressive episode (MDE) among full-time college students and other young adults aged 18 to 22. Data on past year MDE, severity of impairment due to symptoms of depression, and receipt of speciality mental health treamtent are presented for full-time college students and other young adults, with some comparisons by gender and race/ethnicity.

Tags: college-students, major-depressive-episode, mental-health-treatment, samhsa, young-adults
Organization: U.S. Department of Health & Human Services
National Survey of Substance Abuse Treatment Services (N-SSATS): 2008 Data on Substance Abuse Treatment Facilities

This report presents results from the 2008 National Survey of Substance Abuse Treatment Services (N-SSATS), an annual census of facilities providing substance abuse treatment. Conducted by the Substance Abuse and Mental Health Services Administration (SAMHSA), the N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 states, the District of Columbia, and other U.S. jurisdictions.

Tags: alcohol-drug-abuse, n-ssats, samhsa, substance-abuse-treatment, treatment-facilities
Organization: U.S. Department of Health & Human Services
Is It Injury or Neglect? Improving Our Knowledge to Better Protect Children

This webinar presenters discussed efforts to better define neglect in the context of accidental injury and described models of child death case reviews that will lead to improved understanding, reporting, and prevention strategies.

Presenters: Steven Wirtz, California Department of Public Health; Theresa Covington, National Center on Child Death Review; and Stephanie Biegler, Child Abuse Prevention Council of Sacramento, Inc.

View Webinar (WMV - 55 MB)

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: abuse, neglect, policy, prevention, reporting
Organization: U.S. Department of Health & Human Services
2011 NSDUH Instrumentation Protocol Changes

This report documents instrumentation protocol changes occurring between the 2010 National Survey on Drug Use and Health (NSDUH) and the 2011 NSDUH. This summary document is divided into three topics: 1) computer-assisted interviewing (CAI) screening instrument, 2) the CAI Questionnaire, and 3) the interviewer materials.

Tags: instrumentation-changes, nsduh, samhsa, substance-use, survey-methodology
Organization: U.S. Department of Health & Human Services
New York City – 5 Boros: Drug-Related Emergency Department Visits, 2004-2011 - Underage Drinking

Excel file with estimates, rates, relative standard errors, trends and confidence intervals for all drug-related emergency department (ED) visits involving underage drinking in New York City (5 boroughs), covering 2004-2011.  Underage drinking includes ED visits that involve alcohol use (alone or with other drugs) for patients under the age of 21.

Tags: alcohol-related-visits, emergency-department, nyc-boroughs, samhsa, underage-drinking
Organization: U.S. Department of Health & Human Services
Long term adaptation of a microbial population to a permanent metabolic constraint: overcoming thymineless death by experimental evolution of

Background
          To maintain populations of microbial cells under controlled conditions of growth and environment for an indefinite duration is a prerequisite for experimentally evolving natural isolates of wild-type species or recombinant strains. This goal is beyond the scope of current continuous culture apparatus because these devices positively select mutants that evade dilution, primarily through attachment to vessel surfaces, resulting in persistent sub-populations of uncontrollable size and growth rate.
        
        
          Results
          To overcome this drawback, a device with two growth chambers periodically undergoing transient phases of sterilization was designed. The robustness of this device was assessed by propagating an E. coli strain under permanent thymine starvation for over 880 days, i.e. metabolic conditions notoriously known to lead to cell death and clogging of cultivation vessels. Ten thousand generations were required to obtain a descendant lineage that could resist thymine starvation and had recovered wild-type growth rate.
        
        
          Conclusions
          This approach provides a technological framework for the diversification and improvement of microbial strains by long-term adaptation to inescapable metabolic constraints. An E. coli strain that is totally resistant to thymineless death was selected.

Tags: e-coli, experimental-evolution, microbial-adaptation, nih, thymine-starvation
Organization: U.S. Department of Health & Human Services
Table 11. Perceptions of Great Risk of Having Five or More Drinks of an Alcoholic Beverages Once or Twice a Week among Persons Aged 12 or Older, by State and Substate Regions: Percentages, Annual Averages Based on 2010, 2011, and 2012 NSDUHs

Table 11. Perceptions of Great Risk of Having Five or More Drinks of an Alcoholic Beverages Once or Twice a Week among Persons Aged 12 or Older, by State and Substate Regions: Percentages, Annual Averages Based on 2010, 2011, and 2012 NSDUHs

Tags: adolescent-alcohol-use, alcohol-risk-perception, heavy-drinking, nsduh-data, samhsa
Organization: U.S. Department of Health & Human Services
Hawaii (HI)

This report presents Hawaii\'s estimates for 25 measures of substance use and mental health based on the combined 2009 and 2010 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for Hawaii for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: hawaii-health, mental-health, nsduh-data, samhsa, substance-use
Organization: U.S. Department of Health & Human Services