AndreaBozzo/ceres-open-data-index huggingface dataset:
Wisconsin 2016 Potential Areas for Addressing Service Gaps for Opioid Treatment

The purpose of the medication-assisted treatment (MAT) facility maps is to identify areas on a state-by-state basis that may be potentially underserved by existing treatment facilities. The maps are created with a methodology that seeks to include the highest potential need areas from individual counties so that county-level stakeholders are also informed. The maps are meant to be used as a tool for policy makers to determine potentially underserved areas—not as a definitive representation of these areas.

Tags: mat-access, opioid-treatment, samhsa, service-gaps, wisconsin-opioids
Organization: U.S. Department of Health & Human Services
Vermont (VT)

This report presents Vermont\'s estimates for 25 measures of substance use and mental health based on the combined 2009 and 2010 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for Vermont for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: mental-health, nsduh, samhsa, substance-use, vermont
Organization: U.S. Department of Health & Human Services
Albuquerque, NM

This report presents combined 2005 to 2010 National Survey on Drug Use and Health (NSDUH) results for those aged 12 or older in the Albuquerque, New Mexico metro area. The report includes estimates of substance use disorder, major depressive episode, illicit drug use, marijuana use, cigarette use, binge alcohol use, and the nonmedical use of prescription-type pain relievers. Results are provided for Albuquerque, New Mexico, and the U.S. overall.

Tags: alcohol-abuse, major-depression, prescription-painkillers, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Evidence for modulation of pericryptal sheath myofibroblasts in rat descending colon by Transforming Growth Factor β and Angiotensin II.

Background
          Absorption of water and Na+ in descending colonic crypts is dependent on the barrier function of the surrounding myofibroblastic pericryptal sheath. Here the effects of high and low Na+ diets and exposure to whole body ionising radiation on the growth and activation of the descending colonic pericryptal myofibroblasts are evaluated. In addition the effect of a post-irradiation treatment with the angiotensin converting enzyme inhibitor Captopril was investigated.
        
        
          Methods
          The levels of Angiotensin II type 1 receptor (AT1), ACE, collagen type IV, transforming growth factor-β type 1 receptor (TGF-βR1), OB cadherin and α-smooth muscle actin in both descending colon and caecum were evaluated, using immunocytochemistry and confocal microscopy, in rats fed on high and low Na+ diets (LS). These parameters were also determined during 3 months post-irradiation with 8Gy from a 60Co source in the presence and absence of the angiotensin converting enzyme inhibitor, Captopril.
        
        
          Results
          Increases in AT1 receptor (135.6% ± 18.3, P < 0.001); ACE (70.1% ± 13.1, P < 0.001); collagen type IV (49.6% ± 15.3, P < 0.001); TGF-β1 receptors (291.0% ± 26.5, P < 0.001); OB-cadherin (26.3% ± 13.8, P < 0.05) and α-smooth muscle actin (82.5% ± 12.4, P < 0.001) were observed in the pericryptal myofibroblasts of the descending colon after LS diet. There are also increases in AT1 receptor and TGF-β1 receptor, smooth muscle actin and collagen type IV after irradiation. Captopril reduced all these effects of irradiation on the pericryptal sheath and also decreased the amount of collagen and smooth muscle actin in control rats (P < 0.001).
        
        
          Conclusions
          These results demonstrate an activation of descending colonic myofibroblasts to trophic stimuli, or irradiation, which can be attenuated by Captopril, indicative of local trophic control by angiotensin II and TGF-β release.

Tags: angiotensin-ii, colon-myofibroblasts, nih, radiation-effects, transforming-growth-factor
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Nebraska, 2014

This is a behavioral health report for the state of Nebraska. It uses the  National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment Services (NSSATS) to address the topics of youth substance use , youth mental health and treatment, adult mental health and treatment, substance use, substance use treatment, and medicare enrollees for the years 2009 to 2013.

Tags: adult-mental-health, nebraska-behavioral-health, samhsa, substance-use-treatment, youth-substance-use
Organization: U.S. Department of Health & Human Services
Optimality of the genetic code with respect to protein stability and amino-acid frequencies

Background
          The genetic code is known to be efficient in limiting the effect of mistranslation errors. A misread codon often codes for the same amino acid or one with similar biochemical properties, so the structure and function of the coded protein remain relatively unaltered. Previous studies have attempted to address this question quantitatively, by estimating the fraction of randomly generated codes that do better than the genetic code in respect of overall robustness. We extended these results by investigating the role of amino-acid frequencies in the optimality of the genetic code.
        
        
          Results
          We found that taking the amino-acid frequency into account decreases the fraction of random codes that beat the natural code. This effect is particularly pronounced when more refined measures of the amino-acid substitution cost are used than hydrophobicity. To show this, we devised a new cost function by evaluating in silico the change in folding free energy caused by all possible point mutations in a set of protein structures. With this function, which measures protein stability while being unrelated to the code's structure, we estimated that around two random codes in a billion (109) are fitter than the natural code. When alternative codes are restricted to those that interchange biosynthetically related amino acids, the genetic code appears even more optimal.
        
        
          Conclusions
          These results lead us to discuss the role of amino-acid frequencies and other parameters in the genetic code's evolution, in an attempt to propose a tentative picture of primitive life.

Tags: amino-acid-frequencies, genetic-code-optimality, mistranslation-errors, nih, protein-stability
Organization: U.S. Department of Health & Human Services
Compound 528357: 6-Methylheptyl nonadecanoate

Chemical compound data from PubChem database. IUPAC Name: 6-methylheptyl nonadecanoate. Molecular Formula: C27H54O2. Molecular Weight: 410.7. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 528492: Eicosane, 7-ethyl

Chemical compound data from PubChem database. IUPAC Name: 7-ethylicosane. Molecular Formula: C22H46. Molecular Weight: 310.6. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2010 CMHS Uniform Reporting System (URS) Output Tables for Utah

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2010. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, national-outcome-measures, samhsa, urs-data
Organization: U.S. Department of Health & Human Services
Multi-exon deletions of the

Background
          Mutations in the fibrillin -1 gene (FBN1) cause Marfan syndrome (MFS), an autosomal dominant multi-system connective tissue disorder. The 200 different mutations reported in the 235 kb, 65 exon-containing gene include only one family with a genomic multi-exon deletion.
        
        
          Methods
          We used long-range RT-PCR for mutation detection and long-range genomic PCR and DNA sequencing for identification of deletion breakpoints, allele-specific transcript analyses to determine stability of the mutant RNA, and pulse-chase studies to quantitate fibrillin synthesis and extracellular matrix deposition in cultured fibroblasts. Southern blots of genomic DNA were probed with three overlapping fragments covering the FBN1 coding exons
        
        
          Results
          Two novel multi-exon FBN1 deletions were discovered. Identical nucleotide pentamers were found at or near the intronic breakpoints. In a Case with classic MFS, an in-frame deletion of exons 42 and 43 removed the C-terminal 24 amino acids of the 5th LTBP (8-cysteine) domain and the adjacent 25th calcium-binding EGF-like (6-cysteine) domain. The mutant mRNA was stable, but fibrillin synthesis and matrix deposition were significantly reduced. A Case with severe childhood-onset MFS has a de novo deletion of exons 44–46 that removed three EGF-like domains. Fibrillin protein synthesis was normal, but matrix deposition was strikingly reduced. No genomic rearrangements were detected by Southern analysis of 18 unrelated MFS samples negative for FBN1 mutation screening.
        
        
          Conclusions
          Two novel deletion cases expand knowledge of mutational mechanisms and genotype/phenotype correlations of fibrillinopathies. Deletions or mutations affecting an LTBP domain may result in unstable mutant protein cleavage products that interfere with microfibril assembly.

Tags: connective-tissue-disorder, exon-deletion, fbn1-gene, marfan-syndrome, nih
Organization: U.S. Department of Health & Human Services
2018 Uniform Reporting System (URS) Table for Florida

This is the 2018 Uniform Reporting System (URS) Output Tables for Florida. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-program, florida, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
2016 Uniform Reporting System (URS) Table for Washington

This is the 2016 Uniform Reporting System (URS) Output Tables for Washington. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-data, mental-health-services, national-outcome-measures, samhsa, substance-abuse-treatment
Organization: U.S. Department of Health & Human Services
Compound 525117: 3-Chloropropyl isohexanoate

Chemical compound data from PubChem database. IUPAC Name: 3-chloropropyl 4-methylpentanoate. Molecular Formula: C9H17ClO2. Molecular Weight: 192.68. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2018-2020 NSDUH Overview and Summary of Substate Region Estimation Methodology

Substate estimates for these years are no longer available due to methodological concerns with combining 2020 data with data from 2018 and 2019. We apologize for any inconvenience or confusion this may cause.Because of the COVID-19 pandemic, most respondents answered the survey via the web in Quarter 4 of 2020, even though all responses in Quarter 1 were from in-person interviews. It is known that people may respond to the survey differently while taking it online, thus introducing what is called a mode effect.When the state estimates were released, it was assumed that the mode effect was similar for different groups of people. However, later analyses have shown that this assumption should not be made. Because of these analyses, along with concerns about the rapid societal changes in 2020, it was determined that averages across the three years could be misleading.For more detail on this decision, see the 2018-2020substate data page.

Tags: estimation-methodology, mental-health, samhsa, substance-use, survey-methodology
Organization: U.S. Department of Health & Human Services
Table 18. Alcohol Dependence in the Past Year among Persons Aged 12 or Older, by State and Substate Regions: Percentages, Annual Averages Based on 2010, 2011, and 2012 NSDUHs

Table 18. Alcohol Dependence in the Past Year among Persons Aged 12 or Older, by State and Substate Regions: Percentages, Annual Averages Based on 2010, 2011, and 2012 NSDUHs

Tags: adolescent-alcohol-use, alcohol-dependence, nsduh-data, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
2022-2023 NSDUH: Guide to State Tables and Summary of Small Area Estimation Methodology

Use this guide to help interpret the 2022-2023 state-level estimates from the National Surveys on Drug Use and Health (NSDUH). It includes a summary of NSDUH and the small area estimation (SAE) methodology, as well as sample sizes, response rates, and total population estimates for the associated tables.

Tags: mental-health, samhsa, small-area-estimation, state-level-data, substance-use
Organization: U.S. Department of Health & Human Services
Compound 525324: Pyrazolo[1,5-d][1,2,4]triazin-3-one, 2,5,6,7,7-pentamethyl

Chemical compound data from PubChem database. IUPAC Name: 2,5,6,7,7-pentamethylpyrazolo[1,5-d][1,2,4]triazin-4-one. Molecular Formula: C10H16N4O. Molecular Weight: 208.26. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
North Carolina 2016 Potential Areas for Addressing Service Gaps for Opioid Treatment

The purpose of the medication-assisted treatment (MAT) facility maps is to identify areas on a state-by-state basis that may be potentially underserved by existing treatment facilities. The maps are created with a methodology that seeks to include the highest potential need areas from individual counties so that county-level stakeholders are also informed. The maps are meant to be used as a tool for policy makers to determine potentially underserved areas—not as a definitive representation of these areas.

Tags: mat-access, north-carolina, opioid-treatment, samhsa, service-gap-analysis
Organization: U.S. Department of Health & Human Services
Compound 525157: Glycerol-propyleneglycol ether, triacetate

Chemical compound data from PubChem database. IUPAC Name: 2-(2,3-diacetyloxypropoxy)propyl acetate. Molecular Formula: C12H20O7. Molecular Weight: 276.28. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Table 6. Illicit Drug Use Other Than Marijuana in the Past Month, by Age Group and State: Percentages, Annual Averages Based on 2013 and 2014 NSDUHs

Table 6. Illicit Drug Use Other Than Marijuana in the Past Month, by Age Group and State: Percentages, Annual Averages Based on 2013 and 2014 NSDUHs

Tags: drug-prevalence, illicit-drug-use, nsduh, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Time Between TPR and Finalization: 10/1/2003 - 9/30/2004

This report provides state-specific data from fiscal year 2004 about the time between the termination of parental rights and the adoption finalization for public agency adoptions.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: adoption, child, data, fiscal, policy
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Colorado, 2013

This is a behavioral health report for the state of Colorado. It uses the  National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment Services (NSSATS) to address the topics of youth substance use , youth mental health and treatment, adult mental health and treatment, substance use, and substance use treatment  for the years 2008 to 2012.

Tags: adult-mental-health, colorado-behavioral-health, samhsa, substance-abuse-treatment, youth-substance-use
Organization: U.S. Department of Health & Human Services
National Survey of Substance Abuse Treatment Services: State Profiles 2004

The 2004 National Survey of Substance Abuse Treatment Services (N-SSATS) is an annual survey of facilities providing substance abuse treatment. The N-SSATS, conducted by the Substance Abuse and Mental Health Services Administration (SAMHSA), is designed to collect data on the location, characteristics, services offered, and number of clients in treatment at alcohol and drug abuse facilities (both public and private) throughout the 50 states, the District of Columbia, and other U.S. jurisdictions.

Tags: alcohol-drug-abuse, n-ssats, samhsa, substance-abuse-treatment, treatment-facilities
Organization: U.S. Department of Health & Human Services
Prevention Training for Home Visitors

Child welfare agencies continue to seek effective, affordable, and time-saving professional development for caseworkers. This episode features the Institute for the Advancement of Family Support Professionals, a collaboration between State agencies, universities, and home visiting organizations that offers 66 e-learning modules supporting the National Family Support Competency Framework. The framework is a shared model of competencies and skills common across home visiting and child welfare professionals.

This episode features a conversation with Laurel Aparicio, director, Early Impact Virginia, and Janet Horras, State home visitation director, Iowa Department of Public Health.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: child, home, policy, prevention, scope
Organization: U.S. Department of Health & Human Services
2014-2015 NSDUH: Guide to State Tables and Summary of Small Area Estimation Methodology

This report provides a guide to the development and presentation of 2014-2015 state estimates. A summary of the methodology is included as well as sample sizes, response rates, and population estimates.

Tags: mental-health, samhsa, small-area-estimation, state-level-data, substance-use
Organization: U.S. Department of Health & Human Services
Compound 528513: Hexadecane, 4-hexyl

Chemical compound data from PubChem database. IUPAC Name: 7-propylnonadecane. Molecular Formula: C22H46. Molecular Weight: 310.6. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
A Review of the Adverse Effects of Peripheral Alpha-1 Antagonists in Hypertension Therapy

Background
          Doxazosin and its role as an antihypertensive agent have come under recent scrutiny as a result of the early termination of that treatment arm in ALLHAT. It is unclear why the cardiovascular (CV) event rate in this randomized, controlled trial (RCT), especially heart failure, is higher in those treated with a doxazosin-based regimen than with a chlorthalidone based-regimen. There has been little work in the past to summarize information on peripheral alpha-1 antagonists that may be helpful in evaluating the results of this randomized controlled trial.
        
        
          Methods
          Using Medline and the Cochrane databases, we performed a comprehensive review of the literature on the use of peripheral alpha-1 antagonists as antihypertensive agents, focusing on available information that could explain the excess cardiovascular events observed in the Antihypertensive and Lipid-Lowering Treatment to prevent Heart Attack Trial (ALLHAT).
        
        
          Results
          Minimal data were available concerning the effects of peripheral alpha-1 antagonists on CV endpoints. A multitude of short-term studies-ranging from small observational studies to short-term moderate-sized RCTs – focused on safety, efficacy, and tolerability, and some studies investigated the physiologic effects of these agents. These previously reported studies reveal associations with weight gain, fluid retention, and neurohormonal changes among various populations of those treated with peripheral alpha-1 antagonists.
        
        
          Conclusion
          These findings suggest several possible mechanisms by which doxazosin may be inferior to low-dose diuretics as antihypertensive therapy for the prevention of heart failure.

Tags: adverse-effects, alpha-1-antagonists, cardiovascular-events, hypertension-therapy, nih
Organization: U.S. Department of Health & Human Services
2016  Uniform Reporting System (URS) Table for Federated States of Micronesia

This is the 2016 Uniform Reporting System (URS) Output Tables for Federated States of Micronesia. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-program, mental-health-services, micronesia, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Depression Care among Depressed Adults with and without Comorbid Substance Use Disorders in the United States

This study will examine receipt of depression care and perceived helpfulness of depression care among adults with major depressive episodes (MDE) and with and without comorbid SUD.Depression Care among Depressed Adults with and without Comorbid Substance Use Disorders in the United States(link is external)

Tags: comorbid-disorders, depression-care, major-depressive-episode, samhsa, substance-use-disorder
Organization: U.S. Department of Health & Human Services