AndreaBozzo/ceres-open-data-index huggingface dataset:
Statistics on continuous IBD data: Exact distribution evaluation for a pair of full(half)-sibs and a pair of a (great-) grandchild with a (great-) grandparent

Background
          Pairs of related individuals are widely used in linkage analysis. Most of the tests for linkage analysis are based on statistics associated with identity by descent (IBD) data. The current biotechnology provides data on very densely packed loci, and therefore, it may provide almost continuous IBD data for pairs of closely related individuals. Therefore, the distribution theory for statistics on continuous IBD data is of interest. In particular, distributional results which allow the evaluation of p-values for relevant tests are of importance.
        
        
          Results
          A technology is provided for numerical evaluation, with any given accuracy, of the cumulative probabilities of some statistics on continuous genome data for pairs of closely related individuals. In the case of a pair of full-sibs, the following statistics are considered: (i) the proportion of genome with 2 (at least 1) haplotypes shared identical-by-descent (IBD) on a chromosomal segment, (ii) the number of distinct pieces (subsegments) of a chromosomal segment, on each of which exactly 2 (at least 1) haplotypes are shared IBD. The natural counterparts of these statistics for the other relationships are also considered. Relevant Maple codes are provided for a rapid evaluation of the cumulative probabilities of such statistics. The genomic continuum model, with Haldane's model for the crossover process, is assumed.
        
        
          Conclusions
          A technology, together with relevant software codes for its automated implementation, are provided for exact evaluation of the distributions of relevant statistics associated with continuous genome data on closely related individuals.

Tags: genome-data, ibd-sharing, linkage-analysis, nih, sib-pairs
Organization: U.S. Department of Health & Human Services
Serum folate levels after UVA exposure: a two-group parallel randomised controlled trial

Background
          Photodegradation of certain vitamins such as riboflavins, carotinoids, tocopherol, and folate has been well-documented. Previous observations suggest that ultraviolet (UV) radiation may cause folate deficiency. This is of great importance since folate deficiency is also known to be linked with the development of neural tube defects. To investigate the influence of UVA radiation on serum folate levels in vivo, we conducted a two-group randomised controlled trial on healthy subjects.
        
        
          Material and methods
          Twenty-four healthy volunteers with skin type II were enrolled into the study. Eight volunteers of the study population were randomly assigned to the control group. UVA irradiation was administered with an air-conditioned sunbed. Blood samples were taken from all volunteers at baseline (T1), 30 min after the first UVA exposure (T2), and at the end of the study 24 h after the sixth UV exposure (T3). The volunteers had two UVA exposures weekly within three weeks (cumulative UVA dose: 96 J/cm2). Volunteers of the control group had no UVA exposures. Serum folate was analysed with an automated immunoassay system.
        
        
          Results
          At all times of blood collection the differences between serum folate levels were insignificant (P > 0.05), except of the non-exposed controls at T2 (P < 0.05). We did not observed significant differences of folate levels between UVA exposed and non-exposed volunteers (P > 0.05).
        
        
          Conclusions
          Our data suggest that both single and serial UVA exposures do not significantly influence serum folate levels of healthy subjects. Therefore, neural tube defects claimed to occur after periconceptual UVA exposure are probably not due to UVA induced folate deficiency.

Tags: folate-deficiency, nih, randomized-controlled-trial, serum-folate, uva-exposure
Organization: U.S. Department of Health & Human Services
Compound 527288: 2,2,2-Trichloroethyl 2-methylpropanoate

Chemical compound data from PubChem database. IUPAC Name: 2,2,2-trichloroethyl 2-methylpropanoate. Molecular Formula: C6H9Cl3O2. Molecular Weight: 219.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Return to fertility after extended chemical castration with a GnRH antagonist

Background
          Antagonistic analogues of GnRH for the treatment of prostate cancer may be used clinically in persons for whom return to fertility after such treatment is important or desirable. The purpose of this study was, therefore, to evaluate the effects of a long term treatment with orntide, a GnRH antagonist, on testosterone levels and fertility in male rats.
        
        
          Methods
          Two groups of male rats received either 120-day orntide microspheres (8.8 mg orntide/kg/120 days) or vehicle alone (control group). Serum orntide and testosterone levels in both groups were monitored at certain intervals for 9 months from the initiation of treatment. After recovery of normal serum testosterone levels in the treated animals, each rat was housed with two proven breeder, but drug-naive, females.
        
        
          Results
          All mates of treated rats achieved pregnancy as rapidly as the mates of control rats although two of the control rats did not sire a litter with either female and one sired only one litter. The mean size of the litters of treated (12.3 offspring per litter) and control (10.6 offspring per litter) were similar. All offspring were grossly normal morphologically and behaviorally during the time to weaning.
        
        
          Conclusions
          These results suggest that lack of fertility due to testosterone suppression is reversible after cessation of treatment with this GnRH antagonist.

Tags: gnrh-antagonist, male-fertility, nih, prostate-cancer-treatment, testosterone-levels
Organization: U.S. Department of Health & Human Services
Receiving Adoption Subsidy: 10/1/2009 - 9/30/2010

This report provides state-specific data from fiscal year 2010 about the number of children who are adopted through a public agency and who receive an adoption subsidy.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: adoption, child, data, fiscal, policy
Organization: U.S. Department of Health & Human Services
2017 Uniform Reporting System (URS) Table for Nevada

This is the 2017 Uniform Reporting System (URS) Output Tables for Nevada. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-data, mental-health-services, nevada-urs, noms-measures, samhsa
Organization: U.S. Department of Health & Human Services
Table 5. First Use of Marijuana, by Age Group and State: Average Annual Rates Based on 2010 and 2011 NSDUHs

This report presents State estimates for measure of first use of marijuana based on the combined 2010 and 2011 National Surveys on Drug Use and Health (NSDUHs). Resuts are provided by age group.

Tags: age-groups, marijuana-initiation, nsduh, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Changes to the Court Improvement Program and Updated Instructions on Submitting New 5-Year Strategic Plans and Applying for Funds

This Program Instruction provides information on changes to the CIP that become effective in FY 2022 and provides updated and supplemental guidance on actions need to apply for FY 2022 state CIP funding.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: child, guidance, instruction, mental, policy
Organization: U.S. Department of Health & Human Services
2017 Uniform Reporting System (URS) Table for District of Columbia

This is the 2017 Uniform Reporting System (URS) Output Tables for District of Columbia. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-program, community-mental-health, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
5.1 Clients in treatment, by primary focus of facility and facility operation: March 31, 2011. Number and percent distribution

This is a National Survey of Substance Abuse Treatment Services (N-SSATS) data table showing clients in treatment, by primary focus of facility and facility operation in 2011. N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 States, the District of Columbia, and other U.S. jurisdictions.

Tags: alcohol-drug-abuse, n-ssats, samhsa, substance-abuse-treatment, treatment-facility-focus
Organization: U.S. Department of Health & Human Services
Von Willebrand factor propeptide as a marker of disease activity in systemic sclerosis (scleroderma)

In 44 consecutive patients with systemic sclerosis (SSc), plasma concentrations of von Willebrand factor (vWf) were higher than those of the vWf propeptide, but the propeptide showed less variability within patient subgroups. Higher values of the propeptide were observed in patients with early pulmonary involvement. A closer correlation of the propeptide than of vWf to biochemical markers of activity was also evident. Our results suggest that the propeptide, despite a shorter circulating half-time and lower plasma concentrations than vWf, is more useful in the assessment of disease activity in SSc.

Tags: disease-activity, nih, pulmonary-involvement, systemic-sclerosis, vwf-propeptide
Organization: U.S. Department of Health & Human Services
Table 2. Marijuana Use in the Past Year, by Age Group and State: Percentages, Annual Averages Based on 2013 and 2014 NSDUHs

Table 2. Marijuana Use in the Past Year, by Age Group and State: Percentages, Annual Averages Based on 2013 and 2014 NSDUHs

Tags: adolescent-health, marijuana-use, nsduh-data, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Alarms in the intensive care unit: how can the number of false alarms be reduced?

Many alarms, as they now exist in most monitoring systems, are not usually perceived as helpful by the medical staff because of the high incidence of false alarms. This paper gives an overview of the problems related to their current design and the objectives of monitoring. The current approaches used to improve the situation are then presented from two main standpoints: organizational and behavioural on the one hand, and technical on the other.

Tags: critical-care, false-alarms, icu-alarms, nih, patient-monitoring
Organization: U.S. Department of Health & Human Services
Nebraska (NE)

This report presents estimates for measures of substance use and mental health based on the combined 2010 and 2011 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for Nebraska for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: illicit-drugs, mental-health, samhsa, state-survey, substance-use
Organization: U.S. Department of Health & Human Services
2012 Uniform Reporting System (URS) Tables for Georgia

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2012. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, georgia-mental-health, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
2016-2017 NSDUH State Estimates of Substance Use and Mental Disorders

These are the state-level estimates for combined 2016 and 2017 NSDUHs.  Part 1 is released in late November and part 2 in February after the close of the NSDUH data collection.

Tags: mental-disorders, nsduh, samhsa, state-estimates, substance-use
Organization: U.S. Department of Health & Human Services
NSDUH 2020 Person-Level Sampling Weight Calibration Report

Learn about the techniques used to create weights for the 2020 National Survey on Drug Use and Health (NSDUH) at the person level. The report reviews the generalized exponential model (GEM) used in weighting, discusses potential predictor variables, and details the practical steps used to implement GEM. The report also details the weight calibrations, and presents the evaluation measures of the calibrations, as well as a sensitivity analysis.Chapters:Introduces the survey design, weight components, and the remainder of the report.Discusses the impact of the survey interruption on the weighting for 2020.Reviews GEM and outlines how GEM provides a unified approach to adjustments for nonresponse, poststratification, and extreme weights.Discusses potential predictor variables and the strategy for dealing with many predictors.Discusses extreme weights in the GEM.Discusses the control totals for poststratification adjustments.Details the weight calibrations at the dwelling unit level.Discusses the design weight components and weight calibration at the person level.Presents the evaluation measures of calibrated weights and a sensitivity analysis of selected prevalence estimates.Discusses the break-off analysis weights.Appendices include technical details about the model and the evaluations that were performed.

Tags: samhsa, sampling-weights, statistical-analysis, substance-use, survey-methodology
Organization: U.S. Department of Health & Human Services
Cytochrome P450 2E1 polymorphism and nasopharyngeal carcinoma development in Thailand: a correlative study

Background
          Nasopharyngeal carcinoma (NPC) is a rare tumor in most parts of the world but occurs at relatively high frequency among people of Chinese descent. The cytochrome P450 2E1 enzyme (CYP2E1) is responsible for the metabolic activation of nitrosamines, and has been shown to be a susceptibility gene for NPC development in Taiwan [RR = 2.6; 95%CI = 1.2-5.7]. Since there has been only one report of this link, it was decided to investigate the susceptibility of CYP2E1 to NPC development in other populations. Therefore, the correlation between the RsaI polymorphism of this gene and NPC was studied in-patients including Thai and Chinese in Thailand. The present study comprised 217 cases diagnosed with NPC and 297 healthy controls.
        
        
          Results
          Similar to the result found in Taiwanese, a homozygous uncut genotype demonstrated a higher relative risk both when all cases were analyzed [RR = 2.19; 95%CI = 0.62-8.68] or individual racial groups, Thai [RR = 1.51; 95%CI = 0.08-90.06] or Chinese [RR = 1.99; 95%CI = 0.39-10.87]. The ethnicity-adjusted odds ratio is 2.39 with 95%CI, 0.72-7.89.
        
        
          Conclusions
          Though our finding was not statistically significant due to the moderate sample size of the study, similarity to the study in Taiwan with only a slight loss in precision was demonstrated. The higher RR found for the same genotype in distinct populations confirmed that CYP2E1 is one of several NPC susceptibility genes and that the RsaI minus variant is one mutation that affects phenotype.

Tags: cyp2e1-polymorphism, genetic-susceptibility, nasopharyngeal-carcinoma, nih, thai-population
Organization: U.S. Department of Health & Human Services
The acute effects of body position strategies and respiratory therapy in paralyzed patients with acute lung injury

Background:
          Routine turning of critically ill patients is a standard of care. In recent years, specialized beds that provide automated turning have been introduced. These beds have been reported to improve lung function, reduce hospital-acquired pneumonia, and facilitate secretion removal. This trial was designed to measure the physiological effects of routine turning and respiratory therapy in comparison with continuous lateral rotation (CLR).
        
        
          Methods:
          The study was a prospective, quasi-experimental, random assignment, trial with patients serving as their own controls. Paralyzed, sedated patients with acute respiratory distress syndrome were eligible for study. Patients were randomized to receive four turning and secretion management regimens in random sequence for 6 h each over a period of 24 h: (1) routine turning every 2 h from the left to right lateral position; (2) routine turning every 2 h from the left to right lateral position including a 15-min period of manual percussion and postural drainage (P&PD); (3) CLR with a specialized bed that turned patients from left to right lateral position, pausing at each position for 2 min; and (4) CLR with a specialized bed that turned patients from left to right lateral position pausing at each position for 2 min, and a 15-min period of percussion provided by the pneumatic cushions of the bed every 2 h.
        
        
          Results:
          Nineteen patients were entered into the study. There were no statistically significant differences in the measured cardiorespiratory variables. There was a tendency for the ratio of partial pressure of arterial oxygen to fractional inspired oxygen concentration (PaO2/FIO2) to increase (174 ± 31 versus 188 ± 36; P = 0.068) and for the ratio of deadspace to tidal volume (Vd/Vt) to decrease (0.62 ± 0.18 versus 0.59 ± 0.18; P = 0.19) during periods of CLR, but these differences did not achieve statistical significance. There were statistically significant increases in sputum volume during the periods of CLR. The addition of P&PD did not increase sputum volume for the group as a whole. However, in the four patients producing more than 40 ml of sputum per day, P&PD increased sputum volume significantly. The number of patient turns increased from one every 2 h to one every 10 min during CLR.
        
        
          Conclusion:
          The acute effects of CLR are undoubtedly different in other patient populations (spinal cord injury and unilateral lung injury). The link between acute physiological changes and improved outcomes associated with CLR remain to be determined.

Tags: acute-lung-injury, body-positioning, nih, paralyzed-patients, respiratory-therapy
Organization: U.S. Department of Health & Human Services
Drug therapy and adverse drug reactions to terbutaline in obstetric patients: a prospective cohort study in hospitalized women

Background
          Adverse drug reactions (ADR's) could be expected more frequently in pregnant women. This study was performed in order to identify ADR's to tocolytic drugs in hospitalised pregnant women.
        
        
          Methods
          A prospective cohort study was performed in two General Hospitals of the Instituto Mexicano del Seguro Social (IMSS) in Mexico City. Two hundred and seven women undergoing labor, premature labor, threatened abortion or suffering any obstetric related disease were included. Drug prescription and signs and symptoms of any potential ADR were registered daily during the hospital stay. Any potential ADR to tocolytic drugs was evaluated and classified by three of the authors using the Kramer's algorithm.
        
        
          Results
          Of the 207 patients, an ADR was positively classified in 25 cases (12.1%, CI95% 8.1 to 17.5%). All ADR's were classified as minor reactions. Grouping patients with diagnosis of threatened abortion, premature labor or under labor (n= 114), 24 ADR's were related to terbutaline, accounting for a rate of 21.1 ADR's per 100 obstetric patients. Obstetric patients suffering an ADR were older than obstetric patients without any ADR. However, the former received less drugs/day × patient-1 and had a shorter hospital stay (p < 0.05) whereas the dose of terbutaline was similar between the two groups. Terbutaline inhibited uterine motility in women with and without any ADR at a similar rate, 70 and 76% respectively (x2 = 0.07; p = 0.8).
        
        
          Conclusion
          Terbutaline, used as a tocolytic drug, was related to a high frequency of minor ADRs and to a high rate of effcicacy.

Tags: nih, obstetric-adr, pregnancy-outcomes, terbutaline-adr, tocolytic-drugs
Organization: U.S. Department of Health & Human Services
2010-2011 NSDUH National Maps of Prevalence Estimates by State

This report presents maps of State estimates for measures of substance use and mental health based on the combined 2009 and 2010 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Results are provided by age group.

Tags: mental-health, samhsa, state-prevalence, substance-use, suicidal-ideation
Organization: U.S. Department of Health & Human Services
Compound 525561: N,N-Dimethyl-N'-(3-bromophenyl)-p-chlorobenzamidine

Chemical compound data from PubChem database. IUPAC Name: N'-(3-bromophenyl)-4-chloro-N,N-dimethylbenzenecarboximidamide. Molecular Formula: C15H14BrClN2. Molecular Weight: 337.64. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2010 State Profile — New York

This state profile includes data from facilities in New York that reported to N-SSATS for the survey reference date March 31, 2010. Data were collected on the location, characteristics, services offered, and number of clients in treatment at alcohol and drug abuse treatment facilities (both public and private) in New York. In New York, 1,000 substance abuse treatment facilities were included in the 2010 N-SSATS, reporting that there were 130,171 clients in substance abuse treatment on March 31, 2010. The survey response rate in New York was 96.1%.

Tags: addiction-services, n-ssats, new-york-state, samhsa, substance-abuse-treatment
Organization: U.S. Department of Health & Human Services
Compound 528501: 9-Methyltricosane

Chemical compound data from PubChem database. IUPAC Name: 9-methyltricosane. Molecular Formula: C24H50. Molecular Weight: 338.7. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services