AndreaBozzo/ceres-open-data-index huggingface dataset:
2018 Uniform Reporting System (URS) Table for Washington

This is the 2018 Uniform Reporting System (URS) Output Tables for Washington. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: behavioral-health, community-mental-health, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Texas (TX)

This report uses 2008 to 2010 National Survey on Drug Use and Health (NSDUH) to assess past year alcohol use disorder and illicit drug use disorder among persons aged 12 or older for Texas overall and for substate regions within Texas. Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE).

Tags: alcohol-abuse, mental-health-texas, nsduh-data, samhsa, substance-use-disorder
Organization: U.S. Department of Health & Human Services
Genomic structure of the gene for mouse germ cell nuclear factor (GCNF)

Background:
          The germ cell nuclear factor (GCNF, also known as retinoid acid receptor-related testis-associated receptor, neuronal cell nuclear receptor or NR6A1) is an orphan receptor in the nuclear receptor superfamily found in mammals, amphibians and fish. The mouse Gcnf gene is expressed in the placenta and the developing nervous system and germ cells, and responds to retinoic acid.
        
        
          Results:
          We have defined the intron-exon structure of the mouse Gcnf gene and found that it contains 11 exons. Exons 1-4 encode the 75 amino acid amino-terminal domain and exon 4 also encodes the core DNA-binding domain. The carboxy-terminal extension is encoded by exon 5, exons 6 and 7 encode the hinge region, and exons 7-11 encode the putative ligand-binding domain. Unusually, the two zinc-finger motifs in the DNA-binding domain are encoded by separate exons.
        
        
          Conclusions:
          The protein-coding region of GCNF is contained in 11 exons. The genomic structure of this nuclear receptor gene will be useful for further studies.

Tags: gcnf-gene, gene-structure, mouse-genomics, nih, nuclear-receptor
Organization: U.S. Department of Health & Human Services
Seattle-Tacoma-Bellevue, WA

This report presents combined 2005 to 2010 National Survey on Drug Use and Health (NSDUH) results for those aged 12 or older in the Seattle-Tacoma-Bellevue, WA metro area. The report includes estimates of substance use disorder, major depressive episode, illicit drug use, marijuana use, cigarette use, binge alcohol use, and the nonmedical use of prescription-type pain relievers. Results are provided for the Seattle-Tacoma-Bellevue metro area, Washington, and the U.S. overall.

Tags: major-depression, nsduh-data, samhsa, seattle-metro, substance-use
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Region 6, Volume 5

This is a behavioral health report for HHS Region VI of the United States and utilizes data from the National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment (N-SSATS), collected annually. The topics addressed in the reports include youth substance use, youth mental health and treatment, adult mental health, substance use and substance use treatment.

Tags: behavioral-health, mental-health, region-6, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Saline lavage with substitution of bovine surfactant in term neonates
		  with meconium aspiration syndrome (MAS) transferred for extracorporeal membrane
		  oxygenation (ECMO): a pilot study

Background:
          Meconium aspiration syndrome (MAS) is still a condition associated
				with a high mortality, and many patients require extracorporeal membrane
				oxygenation (ECMO) as rescue therapy. Beneficial effects of surfactant and
				perflubron lavage have been reported. However, pure surfactant supplementation
				has not been proven to be beneficial in the most severe forms of MAS. This
				study was performed to demonstrate an improvement in oxygenation in neonates
				transferred for ECMO and fulfilling ECMO criteria with a saline lavage and
				surfactant resupplementation.
        
        
          Methods:
          Twelve newborns with MAS [gestational age 36–40 weeks, mean birth
				weight 3200 g, age 4–16 h, oxygenation index (OI) > 40] transferred for ECMO
				therapy were treated with saline lavage (5–10 cm3/kg body weight, as
				long as green colored retrieval was observed) and resupplementation with bovine
				surfactant (Alveofact, Boehringer, Ingelheim, Germany). The OI at admission and
				3 h after this procedure was compared using the t-test for paired
				samples. ECMO was available as rescue therapy at all times.
        
        
          Results:
          The OI decreased from 49.4 (SD ± 13.3) to 27.4 (SD ± 7.3),
				P < 0.01. The decrease was sustained in nine patients, three
				patients required ECMO and all patients survived.
        
        
          Conclusions:
          As MAS is a condition with parenchymal damage, pulmonary
				hypertension and obstructive airway disease, no simple causative therapy is
				possible. Surfactant application after removal of meconium by extensive lavage
				is feasible as long as 16 h after birth even in infants considered for ECMO
				therapy; it might reduce the necessity of ECMO.

Tags: bovine-surfactant, ecmo-neonates, meconium-aspiration, nih, saline-lavage
Organization: U.S. Department of Health & Human Services
Compound 528590: Pentanoic acid, 5-phenyl, TBDMS

Chemical compound data from PubChem database. IUPAC Name: [tert-butyl(dimethyl)silyl] 5-phenylpentanoate. Molecular Formula: C17H28O2Si. Molecular Weight: 292.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
A comprehensive analysis of 40 blind protein structure predictions

Background
          We thoroughly analyse the results of 40 blind predictions for which an experimental answer was made available at the fourth meeting on the critical assessment of protein structure methods (CASP4). Using our comparative modelling and fold recognition methodologies, we made 29 predictions for targets that had sequence identities ranging from 50% to 10% to the nearest related protein with known structure. Using our ab initio methodologies, we made eleven predictions for targets that had no detectable sequence relationships. 
        
        
          Results
          For 23 of these proteins, we produced models ranging from 1.0 to 6.0 Å root mean square deviation (RMSD) for the Cα atoms between the model and the corresponding experimental structure for all or large parts of the protein, with model accuracies scaling fairly linearly with respect to sequence identity (i.e., the higher the sequence identity, the better the prediction). We produced nine models with accuracies ranging from 4.0 to 6.0 Å Cα RMSD for 60–100 residue proteins (or large fragments of a protein), with a prediction accuracy of 4.0 Å Cα RMSD for residues 1–80 for T110/rbfa.
        
        
          Conclusions
          The areas of protein structure prediction that work well, and areas that need improvement, are discernable by examining how our methods have performed over the past four CASP experiments. These results have implications for modelling the structure of all tractable proteins encoded by the genome of an organism.

Tags: amino-acid-sequence, comparative-modeling, nih, protein-structure, structure-prediction
Organization: U.S. Department of Health & Human Services
Use of Behavioral Health Services is Expected to Increase under the Affordable Care Act (2009 to 2011 NSDUH)

This data spotlight uses 2009 to 2011 National Survey on Drug Use and Health (NSDUH) to estimate the number of people without insurance who are likely to use behavioral health services after they become insured under the Affordable Care Act (ACA).

Tags: affordable-care-act, behavioral-health-services, samhsa, substance-use, uninsured-population
Organization: U.S. Department of Health & Human Services
NSDUH 2023 Public Use File Data Users' Guide

Use this guide to analyze the National Survey on Drug Use and Health (NSDUH) for yourself. This guide provides data users with information and guidance to properly analyze the NSDUH public use files, including descriptions of the survey scope and design; guidelines for navigating the codebook and other methodological resources; and instructions for basic statistical analyses with common software.OverviewHistory of NSDUH and Trend BreaksNSDUH PopulationsSample Design, Data Collection, and Response RatesSelection of Variables for AnalysisUse of Analysis Weights and Variance Estimation VariablesStatistical Disclosure AvoidanceData SubsettingData PoolingEstimation and Statistical TestingGuidance for Suppressing Unreliable EstimatesCoding ExamplesAppendices provide examples of key indicators measured in NSDUH and a table of important NSDUH resources.

Tags: mental-health, samhsa, statistical-analysis, substance-use, survey-methodology
Organization: U.S. Department of Health & Human Services
Compound 528592: Benzenepropanoic acid, alpha-[(tert-butyldimethylsilyl)oxy]-, tert-butyldimethylsilyl ester

Chemical compound data from PubChem database. IUPAC Name: [tert-butyl(dimethyl)silyl] 2-[tert-butyl(dimethyl)silyl]oxy-3-phenylpropanoate. Molecular Formula: C21H38O3Si2. Molecular Weight: 394.7. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Law Enforcement Exchange: State Panel Discussion

This state panel discussion, featuring Florida and New Mexico, discussed alternatives for sharing child welfare and law enforcement data to improve practice. Florida staff described law enforcement involvement in the investigation process as well as automation to support criminal history checks. New Mexico staff described a law enforcement portal, which supports collaborative work with families. Both states discussed lessons learned and the panel concluded with a question and answer session.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: data, law, policy, reporting, sery
Organization: U.S. Department of Health & Human Services
High affinity binding of proteins HMG1 and HMG2 to semicatenated DNA loops

Background
          Proteins HMG1 and HMG2 are two of the most abundant non histone proteins in the nucleus of mammalian cells, and contain a domain of homology with many proteins implicated in the control of development, such as the sex-determination factor Sry and the Sox family of proteins. In vitro studies of interactions of HMG1/2 with DNA have shown that these proteins can bind to many unusual DNA structures, in particular to four-way junctions, with binding affinities of 107 to 109 M-1.
        
        
          Results
          Here we show that HMG1 and HMG2 bind with a much higher affinity, at least 4 orders of magnitude higher, to a new structure, Form X, which consists of a DNA loop closed at its base by a semicatenated DNA junction, forming a DNA hemicatenane. The binding constant of HMG1 to Form X is higher than 5 × 1012 M-1, and the half-life of the complex is longer than one hour in vitro.
        
        
          Conclusions
          Of all DNA structures described so far with which HMG1 and HMG2 interact, we have found that Form X, a DNA loop with a semicatenated DNA junction at its base, is the structure with the highest affinity by more than 4 orders of magnitude. This suggests that, if similar structures exist in the cell nucleus, one of the functions of these proteins might be linked to the remarkable property of DNA hemicatenanes to associate two distant regions of the genome in a stable but reversible manner.

Tags: dna-binding, dna-structure, hmg1-protein, hmg2-protein, nih
Organization: U.S. Department of Health & Human Services
2017 Uniform Reporting System (URS) Table for Oregon

This is the 2017 Uniform Reporting System (URS) Output Tables for Oregon. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: mental-health-services, noms-measures, oregon-mental-health, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: North Dakota, 2014

This is a behavioral health report for the state of North Dakota. It uses the  National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment Services (NSSATS) to address the topics of youth substance use , youth mental health and treatment, adult mental health and treatment, substance use, substance use treatment, and medicare enrollees for the years 2009 to 2013.

Tags: behavioral-health, mental-health, north-dakota, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
2012 State Profile - Puerto Rico

This is a National Survey of Substance Abuse Treatment Services (N-SSATS) annual report showing the state profile for Puerto Rico in 2012. N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 States, the District of Columbia, and other U.S. jurisdictions.

Tags: n-ssats, puerto-rico, samhsa, substance-abuse-treatment, treatment-facilities
Organization: U.S. Department of Health & Human Services
Oriented antibody immobilization to polystyrene macrocarriers for immunoassay modified with hydrazide derivatives of poly(meth)acrylic acid

Background
          Hydrophobic polystyrene is the most common material for solid phase immunoassay. Proteins are immobilized on polystyrene by passive adsorption, which often causes considerable denaturation. Biological macromolecules were found to better retain their functional activity when immobilized on hydrophilic materials. Polyacrylamide is a common material for solid-phase carriers of biological macromolecules, including immunoreagents used in affinity chromatography. New macroformats for immunoassay modified with activated polyacrylamide derivatives seem to be promising.
        
        
          Results
          New polymeric matrices for immunoassay in the form of 0.63-cm balls which contain hydrazide functional groups on hydrophilic polymer spacer arms at their surface shell are synthesized by modification of aldehyde-containing polystyrene balls with hydrazide derivatives of poly(meth)acrylic acid. The beads contain up to 0.31 μmol/cm2 active hydrazide groups accessible for covalent reaction with periodate-oxidized antibodies. The matrices obtained allow carrying out the oriented antibody immobilization, which increases the functional activity of immunosorbents.
        
        
          Conclusions
          An efficient site-directed antibody immobilization on a macrosupport is realized. The polymer hydrophilic spacer arms are the most convenient and effective tools for oriented antibody coupling with molded materials. The suggested scheme can be used for the modification of any other solid supports containing electrophilic groups reacting with hydrazides.

Tags: antibody-immobilization, hydrazide-derivatives, immunoassay-techniques, nih, polystyrene-macrocarriers
Organization: U.S. Department of Health & Human Services
2013 NSDUH Sample Size and Population Estimates Tables (Prevalence Estimates) - 8.1 to 8.13

These detailed tables show sample sizes and population estimates from the 2013 National Survey on Drug Use and Health (NSDUH). Samples sizes and population estimates are provided by age group, gender, race/ethnicity, education level, employment status, geographic area, pregnancy status, college enrollment status, and probation/parole status.

Tags: health-survey, mental-health, population-estimates, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
High-pressure biotechnology in medicine and pharmaceutical science

High-pressure (HP) biotechnology is an emerging technique
initially applied for food processing and more recently in pharmaceutical and medical sciences. Pressure can stabilize enzymes and modulate both their activity and specificity. HP engineering of proteins may be used for enzyme-catalyzed synthesis of fine chemicals, pharmaceuticals, and production of
modified proteins of medical or pharmaceutical interest. HP inactivation of biological agents is expected to be applicable to sterilization of fragile biopharmaceuticals, or medical compounds. The enhanced immunogenicity of some pressure-killed bacteria and viruses could be applied for making new vaccines. Finally, storage at subzero temperatures without freezing is another potential application of HP for cells, animal tissues, blood cells, organs for transplant, and so forth.

Tags: enzyme-stabilization, high-pressure-biotechnology, nih, pharmaceutical-science, vaccine-development
Organization: U.S. Department of Health & Human Services
NSDUH 2022 Data Collection Final Report

Learn about all the data collection operations for the 2022 National Survey on Drug Use and Health (NSDUH). The report details the sampling, counting, and listing operations; field staffing and training; preparation of survey materials; data collection (both in-person and web); and quality control practices. It also includes information on the results of data collection, including detailed response rates.

Tags: mental-health, response-rates, samhsa, substance-use, survey-methodology
Organization: U.S. Department of Health & Human Services
Boston: Drug-Related Emergency Department Visits, 2004-2011 - All Visits

Excel file with estimates, rates, relative standard errors, trends and confidence intervals for all drug-related emergency department (ED) visits in the Boston metropolitan area, covering 2004-2011. File includes all drug-related ED visits that are reportable to DAWN without regard for the reason for the visit or the specific drugs involved. It includes visits involving all forms of drug misuse or abuse plus visits resulting from adverse reaction, accidental ingestion, suicide attempts, and visits where patients were seeking detoxification services. These estimates are useful for looking at overall levels of drug involvement in ED visits.File includes data for over 500 drugs, including illicit drugs, prescription and over-the-counter medications, dietary supplements, inhalants and alcohol.  Includes total visits, gender, age group, race/ethnicity, outcome of visit, drug combinations, number of drugs involved in visit, drug frequency, and drugs confirmed by toxicology.Additional detail is provided for illicit drugs, psychotherapeutic drugs, central nervous system (CNS) drugs, respiratory drugs and cardiovascular drugs.

Tags: boston-ed-data, dawn-data, drug-related-ed-visits, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Washington, 2014

This is a behavioral health report for the state of Washington. It uses the  National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment Services (NSSATS) to address the topics of youth substance use , youth mental health and treatment, adult mental health and treatment, substance use, substance use treatment, and medicare enrollees for the years 2009 to 2013.

Tags: adult-mental-health, samhsa, substance-use-treatment, washington-behavioral-health, youth-substance-use
Organization: U.S. Department of Health & Human Services
Compound 525137: Dodeca-5,7-dienol

Chemical compound data from PubChem database. IUPAC Name: dodeca-5,7-dien-1-ol. Molecular Formula: C12H22O. Molecular Weight: 182.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2017 Uniform Reporting System (URS) Table for West Virginia

This is the 2017 Uniform Reporting System (URS) Output Tables for West Virginia. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: mental-health-services, national-outcome-measures, samhsa, substance-abuse, west-virginia
Organization: U.S. Department of Health & Human Services
Fibroblast biology: Development and differentiation of synovial fibroblasts in arthritis

Synovial fibroblasts occur as two phenotypes - intimal and subintimal. The specialised intimal phenotype includes expression of uridine diphosphoglucose dehydrogenase (UDPGD), vascular cell adhesion molecule-1 (VCAM-1) and complement decay-accelerating factor (DAF). These gene products contribute to specialised functions relating to tissue movement and leucocyte traffic.

Tags: arthritis-research, nih, synovial-fibroblasts, synovium-biology, vcam-1
Organization: U.S. Department of Health & Human Services
Compound 528512: Hexadecane, 4-heptyl

Chemical compound data from PubChem database. IUPAC Name: 8-propylicosane. Molecular Formula: C23H48. Molecular Weight: 324.6. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Support for Use of Naloxone and Other Opioid Overdose Reversal Medications to Prevent Overdose Deaths

Monitoring the distribution and impact of opioid overdose reversal medications such as naloxone is essential to optimizing overdose prevention strategies and improving public health outcomes. This Statistical Data Profile, the first to use performance data from two SAMHSA grant programs, examines the distribution of FDA-approved opioid overdose reversal medications, including naloxone/Narcan. The Data Profile also presents the training of first responders, community organization staff and other individuals to administer the reversal medications and provide other support services.

Tags: first-responder-training, naloxone-distribution, opioid-overdose, overdose-reversal, samhsa
Organization: U.S. Department of Health & Human Services
Publications Using SAMHSA Data2022 NSDUH Companion Infographic

Review this high-level visual representation of key outcomes from the 2022 National Survey on Drug Use and Health (NSDUH). This infographic, accompanying the 2022 NSDUH National Report, covers substance use, substance use disorders, mental health issues, suicidality, and perceived recovery from substance use problems or mental health issues among the noninstitutionalized population aged 12 or older in the United States.

Tags: mental-health, nsduh-data, samhsa, substance-use, suicidality
Organization: U.S. Department of Health & Human Services