AndreaBozzo/ceres-open-data-index huggingface dataset:
National Survey of Substance Abuse Treatment Facilities (N-SSATS): 2014, Data on Substance Abuse Treatment Facilities

This report presents results from the 2014 National Survey of Substance Abuse Treatment Services (N-SSATS), an annual census of facilities providing substance abuse treatment. Conducted by the Substance Abuse and Mental Health Services Administration (SAMHSA), N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 states, the District of Columbia, Puerto Rico, and other U.S. jurisdictions.

Tags: alcohol-drug-abuse, behavioral-health-services, samhsa, substance-abuse-treatment, treatment-facility-census
Organization: U.S. Department of Health & Human Services
AFCARS 2020 Compliance and Penalties

This webinar was a part of the AFCARS Final Rule Training Series. For this webinar, the Children's Bureau shared a revised version of Technical Bulletin 23: Compliance and Data Quality. This webinar:

We encourage you to submit any questions to AFCARS@acf.hhs.gov.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: child, compliance, data, policy, reporting
Organization: U.S. Department of Health & Human Services
Equipment review: Mechanical effects of heat-moisture exchangers in ventilated		  patients

Although they represent a valuable alternative to heated			 humidifiers, artificial noses have unfavourable mechanical effects. Most			 important of these is the increase in dead space, with consequent increase in			 the ventilation requirement. Also, artificial noses increase the inspiratory			 and expiratory resistance of the apparatus, and may mildly increase intrinsic			 positive end-expiratory pressure. The significance of these effects depends on			 the design and function of the artificial nose. The pure humidifying function			 results in just a moderate increase in dead space and resistance of the			 apparatus, whereas the combination of a filtering function with the humidifying			 function may critically increase the volume and the resistance of the			 artificial nose, especially when a mechanical filter is used. The increase in			 the inspiratory load of ventilation that is imposed by artificial noses, which			 is particularly significant for the combined heat-moisture exchanger filters,			 should be compensated for by an increase either in ventilator output or in			 patient's work of breathing. Although both approaches can be tolerated by			 most patients, some exceptions should be considered. The increased pressure and			 volume that are required to compensate for the artificial nose application			 increase the risk of barotrauma and volutrauma in those patients who have the			 most severe alterations in respiratory mechanics. Moreover, those patients who			 have very limited respiratory reserve may not be able to compensate for the			 inspiratory work imposed by an artificial nose. When we choose an artificial			 nose, we should take into account the volume and resistance of the available			 devices. We should also consider the mechanical effects of the artificial noses			 when setting mechanical ventilation and when assessing a patient's			 ability to breathe spontaneously.

Tags: heat-moisture-exchangers, mechanical-ventilation, nih, respiratory-mechanics, ventilator-dead-space
Organization: U.S. Department of Health & Human Services
New insights into the effects on blood pressure of diets low in salt and high in fruits and vegetables and low-fat dairy products

Results from the recent Dietary Approaches to Stop Hypertension (DASH)-Sodium trial provide the latest evidence concerning the effects of dietary patterns and sodium intake on blood pressure. Participants ate either the DASH diet (high in fruits, vegetables and low-fat dairy products, and reduced in saturated and total fat) or a typical US diet. Within each diet arm, participants ate higher, intermediate, and lower sodium levels, each for 30 days. The results indicated lower blood pressure with lower sodium intake for both diet groups. Although some critics would argue otherwise, these findings provide important new evidence for the value of the DASH diet and sodium reduction in controlling blood pressure.

Tags: blood-pressure, dash-diet, hypertension-treatment, nih, sodium-intake
Organization: U.S. Department of Health & Human Services
2013 CMHS Uniform Reporting System (URS) Table for Virginia

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Tables for Virginia for 2013. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program.  State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: behavioral-health-urs, community-mental-health, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
2020 Uniform Reporting System (URS) Table For South Carolina

This is the 2020 Uniform Reporting System (URS) Output Tables for South Carolina. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: mental-health-services, national-outcome-measures, samhsa, south-carolina, substance-abuse
Organization: U.S. Department of Health & Human Services
Research that influences policy and practice – characteristics of operational research to improve malaria control in Mpumalanga Province, South Africa

Background
          Much communicable disease control research has had little impact on local control programme policy and practice for want of an operational component. The operational research model – the systematic search for knowledge on interventions, tools or strategies that enhance programme effectiveness – is gaining recognition as an appropriate method for addressing perplexing questions within public health programmes.
        
        
          Methods
          A series of operational research studies were conducted to refine malaria diagnosis in Mpumalanga Province, South Africa between 1995 and 1999. The grounded theory approach was used with groups of experienced Masters of Public Health students in South Africa and Australia to analyse a compilation of these studies for determining positive and negative attributes of operational research that affect its ability to influence communicable disease control policy and practice.
        
        
          Results
          The principal positive attributes of the operational research studies were high local relevance, greater ability to convince local decision-makers, relatively short lag-time before implementation of findings, and the cost-effective nature of this form of research. Potential negative features elicited included opportunities forfeited by using scarce resources to conduct research and the need to adequately train local health staff in research methodology to ensure valid results and accurate interpretation of findings.
        
        
          Conclusions
          Operational research effectively influenced disease control policy and practice in rural South Africa, by providing relevant answers to local questions and engaging policy-makers. This resulted in accelerated inclusion of appropriate measures into a local communicable disease control programme.

Tags: disease-control-programs, malaria-control, nih, operational-research, south-africa
Organization: U.S. Department of Health & Human Services
2016-2018 NSDUH Substate Region Estimates - Tables

Prevalence estimates for 15 measures of substance use and mental illness are provided along with 95% confidence intervals for persons aged 12 or older for the substance use measures, persons aged 18 or older for the mental illness measures, and persons aged 12-20 for one alcohol measure.

Tags: mental-illness, nsduh-data, prevalence-estimates, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Compound 525368: 2,4,4-Trimethyl-3,5-dithiahexane

Chemical compound data from PubChem database. IUPAC Name: 2-methylsulfanyl-2-propan-2-ylsulfanylpropane. Molecular Formula: C7H16S2. Molecular Weight: 164.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
The role of dyslipidemia and statins in venous thromboembolism

Recent studies have proposed an association between hyperlipidemia and venous thromboembolism (VTE). We review the epidemiological evidence linking dyslipidemia with VTE and examine several possible underlying mechanisms. We discuss the possible role of HMG CoA reductase inhibitors (statins) in the prevention and treatment of VTE and suggest future directions for research.

Tags: dyslipidemia, nih, statin-therapy, thrombosis-risk, venous-thromboembolism
Organization: U.S. Department of Health & Human Services
In silico discovery of novel Retinoic Acid Receptor agonist structures

Background
          Several Retinoic Acid Receptors (RAR) agonists have therapeutic activity against a variety of cancer types; however, unacceptable toxicity profiles have hindered the development of drugs. RAR agonists presenting novel structural and chemical features could therefore open new avenues for the discovery of leads against breast, lung and prostate cancer or leukemia.
        
        
          Results
          We have analysed the induced fit of the active site residues upon binding of a known ligand. The derived binding site models were used to dock over 150,000 molecules in silico (or virtually) to the structure of the receptor with the Internal Coordinates Mechanics (ICM) program. Thirty ligand candidates were tested in vitro.
        
        
          Conclusions
          Two novel agonists resulting from the predicted receptor model were active at 50 nM. One of them displays novel structural features which may translate into the development of new ligands for cancer therapy.

Tags: cancer-agonists, drug-discovery, in-silico-discovery, nih, retinoic-acid-receptor
Organization: U.S. Department of Health & Human Services
2010 State Profile — Illinois

This state profile includes data from facilities in Illinois that reported to N-SSATS for the survey reference date March 31, 2010. Data were collected on the location, characteristics, services offered, and number of clients in treatment at alcohol and drug abuse treatment facilities (both public and private) in Illinois. In Illinois, 606 substance abuse treatment facilities were included in the 2010 N-SSATS, reporting that there were 41,863 clients in substance abuse treatment on March 31, 2010. The survey response rate in Illinois was 93.7%.

Tags: addiction-services, illinois, n-ssats, samhsa, substance-abuse-treatment
Organization: U.S. Department of Health & Human Services
Compound 528488: Eicosane, 4-ethyl

Chemical compound data from PubChem database. IUPAC Name: 4-ethylicosane. Molecular Formula: C22H46. Molecular Weight: 310.6. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 528442: 1-Dodecene, 2,6,10-trimethyl

Chemical compound data from PubChem database. IUPAC Name: 2,6,10-trimethyldodec-1-ene. Molecular Formula: C15H30. Molecular Weight: 210.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Availability of Fiscal Year 2021 Children's Justice Act Grants to States

This Program Information (PI) sets forth the eligibility requirements and the grant application procedures for FY 2021 Children’s Justice Act (CJA) grants and provides the tentative State allocation table.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: child, fiscal, grant, policy, scope
Organization: U.S. Department of Health & Human Services
Compound 527221: 4,8a-dimethyl-6-propan-2-yl-2,6,7,8-tetrahydro-1H-naphthalen-1-ol

Chemical compound data from PubChem database. IUPAC Name: 4,8a-dimethyl-6-propan-2-yl-2,6,7,8-tetrahydro-1H-naphthalen-1-ol. Molecular Formula: C15H24O. Molecular Weight: 220.35. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 525660: 1-Chlorobenzene, 4-(4-bromobenzylidenamino)-

Chemical compound data from PubChem database. IUPAC Name: 1-(4-bromophenyl)-N-(4-chlorophenyl)methanimine. Molecular Formula: C13H9BrClN. Molecular Weight: 294.57. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
The influence of age on the female/male ratio of treated incidence rates in depression

Background
          Poor data exist on the influence of psychosocial variables on the female/male ratio of depression because of the small number of cases and the resulting limited numbers of variables available for investigation. For this investigation a large number of first admitted depressed patients (N = 2599) was available which offered the unique opportunity to calculate age specific sex ratios for different marital and employment status categories.
        
        
          Methods
          Age and sex specific population based depression rates were calculated for first ever admissions for single year intervals. Moving averages with interpolated corrections for marginal values in the age distribution were employed.
        
        
          Results
          For the total group the female/male ratio of depression showed an inverted U-shape over the life-cycle. This pattern was influenced by the group of married persons, which showed a sex-ratio of 3:1 between the age of 30–50, but ratios of around 1:1 at younger and older ages. For not married persons the female/male ratio was already around 2:1 at the age of 18 and rose to 2.5:1 in mid-life and declined to 1 at around 55. The almost parallel decline of depression rates in employed men and women resulted in a female/male ratio of about 2:1 from age 18 to age 50 and became 1 after the age of 60. The female/male ratio among the not employed was about 1, in mid-life it became negative.
        
        
          Conclusions
          Our analyses show that the gender-gap in first admitted depressed patients is age dependent and that psychosocial factors modify the sex ratio.

Tags: age-factors, depression-incidence, mental-health, nih, sex-ratio
Organization: U.S. Department of Health & Human Services
Fragmentation of Golgi complex and Golgi autoantigens during apoptosis and necrosis

Anti-Golgi complex autoantibodies are found primarily in patients with Sjögren's syndrome and systemic lupus erythematosus, although they are not restricted to these diseases. Several Golgi autoantigens have been identified that represent a small family of proteins. Common features of all Golgi autoantigens appear to be their distinct structural organization of multiple α-helical coiled-coil rods in the central domains flanked by non-coiled-coil N-termini and C-termini, and their localization to the cytoplasmic face of Golgi cisternae. Many autoantigens in systemic autoimmune diseases have distinct cleavage products in apoptosis or necrosis and this has raised the possibility that cell death may play a role in the generation of potentially immunostimulatory forms of autoantigens. In the present study, we examined changes in the Golgi complex and associated autoantigens during apoptosis and necrosis. Immunofluorescence analysis showed that the Golgi complex was altered and developed distinctive characteristics during apoptosis and necrosis. In addition, immunoblotting analysis showed the generation of antigenic fragments of each Golgi autoantigen, suggesting that they may play a role in sustaining autoantibody production. Further studies are needed to determine whether the differences observed in the Golgi complex during apoptosis or necrosis may account for the production of anti-Golgi complex autoantibodies.

Tags: apoptosis-necrosis, autoantibodies, golgi-complex, nih, sjogrens-syndrome
Organization: U.S. Department of Health & Human Services
Compound 525550: Benzylidene-(3-ethoxyphenyl)-amine

Chemical compound data from PubChem database. IUPAC Name: N-(3-ethoxyphenyl)-1-phenylmethanimine. Molecular Formula: C15H15NO. Molecular Weight: 225.28. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Genetic epidemiology: Approaches to the genetic analysis of rheumatoid arthritis

The basis of susceptibility to rheumatoid arthritis (RA) is complex, comprising genetic and environmental susceptibility factors. We have reviewed the available approaches to the investigation of the genetic basis of complex diseases and how these are being applied to RA. Affected-sibling-pair methods for nonparametric linkage analysis, linkage-disequilibrium-based approaches, transmission disequilibrium testing, and disease-association studies are discussed. The pros, cons, and limitations of the approaches are considered and are illustrated by examples from the literature about rheumatoid arthritis.

Tags: disease-association, genetic-epidemiology, linkage-analysis, nih, rheumatoid-arthritis
Organization: U.S. Department of Health & Human Services
2023 Uniform Reporting System (URS) Table For Missouri

This is the 2023 Uniform Reporting System (URS) Output Tables for Missouri. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-data, mental-health-services, missouri-mental-health, samhsa, urs-data
Organization: U.S. Department of Health & Human Services
Compound 527284: 3,7-Dimethyloct-6-enyl 4-methylvalerate

Chemical compound data from PubChem database. IUPAC Name: 3,7-dimethyloct-6-enyl 4-methylpentanoate. Molecular Formula: C16H30O2. Molecular Weight: 254.41. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Alabama: 2011-2012 NSDUH

This report presents Alabama\'s estimates for 25 measures of substance use and mental health based on the combined 2011 and 2012 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided by State and for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: major-depressive-episode, mental-health, samhsa, serious-mental-illness, substance-use
Organization: U.S. Department of Health & Human Services
2021 Uniform Reporting System (URS) Table For Mississippi

This is the 2021 Uniform Reporting System (URS) Output Tables for Mississippi. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: mental-health-services, national-outcome-measures, samhsa, substance-abuse, urs-data
Organization: U.S. Department of Health & Human Services
Child Maltreatment 2020

This report presents national data about child abuse and neglect known to child protective services agencies in the United States during federal fiscal year 2020.

Letter from the Associate Commissioner

Acknowledgements

Child Abuse and Neglect Data During the Pandemic

Summary

CHAPTER 1: Introduction

CHAPTER 2: Reports

CHAPTER 3: Children

CHAPTER 4: Fatalities

CHAPTER 5: Perpetrators

CHAPTER 6: Services

CHAPTER 7: Special Focus

APPENDIX A: CAPTA Data Items

APPENDIX B: Glossary

APPENDIX C: State Characteristics

APPENDIX D: State Commentary

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: abuse, assessment, fiscal, maltreatment, neglect
Organization: U.S. Department of Health & Human Services
Sample Size and Population Estimate Tables (Standard Errors and P Values) - 3.1 to 3.8

These detailed tables show standard errors for sample sizes and population estimates from the 2012 National Survey on Drug Use and Health (NSDUH) Mental Health Detailed Tables. Samples sizes and population estimates are provided age group, gender, race/ethnicity, education level, employment status, county type, poverty level, insurance status, overal health, and geographic area.

Tags: mental-health, nsduh-2012, population-estimates, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Compound 527386: 22,26-Dimethyl-tritriacontyl cyanide

Chemical compound data from PubChem database. IUPAC Name: 23,27-dimethyltetratriacontanenitrile. Molecular Formula: C36H71N. Molecular Weight: 518.0. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Immune ablation and stem-cell therapy in autoimmune disease: Experimental basis for autologous stem-cell transplantation

Treatment of rats suffering from florid chronic progressive systemic arthritis or from chronic remitting/relapsing encephalomyelitis with autologous bone marrow transplantation (BMT) is highly effective. This finding was unexpected as the genotype of the bone marrow largely determines the susceptibility of both spontaneous and induced autoimmune diseases in rodents. The success of autologous stem-cell transplantation depends on the completeness of eradication of the effectors of autoimmune disease, in other words activated and memory T lymphocytes. The reviewed experimental data, when translated to the clinic, indicate that the patients should be subjected to a conditioning regimen that induces maximal lymphoablation and that the autologous transplant has to be T-cell depleted.

Tags: arthritis-treatment, autoimmune-diseases, encephalomyelitis-animal-model, nih, stem-cell-transplantation
Organization: U.S. Department of Health & Human Services