AndreaBozzo/ceres-open-data-index huggingface dataset:
2018 N-SSATS State Profiles

These state profiles includes data from facilities that reported to N-SSATS for the survey reference date March 30, 2018. The N-SSATS collects data on the location, characteristics, services offered, and number of clients (collected every other year) in treatment at alcohol and drug abuse treatment facilities (public and private) throughout the 50 states, the District of Columbia, U.S. territories, and other jurisdictions.

Tags: mental-health-services, n-ssats, samhsa, substance-abuse-treatment, treatment-facility-data
Organization: U.S. Department of Health & Human Services
Factors that Influence the Decision Not to Substantiate a CPS Referral

This federally-funded study examined factors that influenced the decision not to substantiate a child protective services (CPS) referral after a child protective services investigation in Washington State. The study was conducted in three distinct phases. Phase I: Child Protective Record Review consisted of a review of administrative records.  Records were extracted from the state child protective database (CAMIS) and a rich dataset of child, family and allegation variables was created.  The variables include demographic information, variables coded from the Washington Assessment of Risk Matrix (WARM) and the Modified Maltreatment Classification System (MMCS) as well as variables derived from a public assistance records match. The Phase I data file includes 2000 cases.  Phase II: Child Protective Caseworker Survey was a mail and telephone survey of child protective services caseworkers in Washington State.  All current child protective caseworkers in Washington State who had more than six months of job experience were invited to participate in the telephone and mail surveys. The Phase II data file includes the 106 respondents who answered both the telephone and mail surveys. Phase III: Child Protective Client Survey was a telephone survey of investigated CPS clients approximately 90 days post investigation.  This dataset also includes records extracted from the state child protective database similar to those in the Phase I dataset.  In addition to variables related to the interviews, the variables include demographic information, variables coded from the WARM and the Maltreatment MMCS as well as variables derived from a public assistance records match. The Phase III data includes data from 303 clients with completed interviews. The data from Phases I, II and III cannot be combined, as there is no common unit of analysis.

Investigators: English, D., Brummel, S., Graham, J. C. & Coghlan, L..

Tags: abuse, care, ndacan, policy, reporting
Organization: U.S. Department of Health & Human Services
Compound 525204: Chloromethyl 3-chloropentanoate

Chemical compound data from PubChem database. IUPAC Name: chloromethyl 3-chloropentanoate. Molecular Formula: C6H10Cl2O2. Molecular Weight: 185.05. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
From the cell biology to the development of new chemotherapeutic approaches against trypanosomatids: dreams and reality.

Members of the Trypanosomatidae family comprise a large number of species that are causative agents of important diseases such as sleeping sickness, Chagas' disease and Leishmaniasis. These organisms are also of biological interest since they are able to change the morphology according to the environment where they live, through a process of reversible cell transformation, and possess structures and organelles that are not found in mammalian cells. This review analyses the process of transformation, which takes place during the life cycle of Trypanosoma cruzi in the vertebrate and invertebrate hosts. Special attention is given to the interaction of the parasite with vertebrate cells. In addition, the present knowledge of structures and organelles such as the nucleus, the plasma membrane, the sub-pellicular microtubules, the flagellum, the kinetoplast-mitochondrion complex, the peroxisome (glycosome), the acidocalcisome and the structures and organelles involved in the endocytic pathway, is reviewed from a cell biology perspective. The possible use of available data for the development of new anti parasite drugs is also discussed.

Tags: chagas-disease, leishmaniasis, nih, sleeping-sickness, trypanosomatidae-infections
Organization: U.S. Department of Health & Human Services
2010 CMHS Uniform Reporting System (URS) Output Tables for Georgia

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2010. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, georgia-mental-health, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Compound 525431: Butane, 2-methyl-3-(methylthio)-

Chemical compound data from PubChem database. IUPAC Name: 2-methyl-3-methylsulfanylbutane. Molecular Formula: C6H14S. Molecular Weight: 118.24. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Phoenix: Drug-Related Emergency Department Visits, 2004-2011 - All Misuse and Abuse

Excel file with estimates, rates, relative standard errors, trends and confidence intervals for all drug-related emergency department (ED) visits involving drug misuse or abuse in the Phoenix metropolitan area, covering 2004-2011. Drug misuse/abuse visits include the use of illicit drugs, nonmedical use of pharmaceuticals, underage drinking and visits where alcohol was combined with another drug.

Tags: drug-abuse, emergency-department, phoenix-metro, samhsa, substance-misuse
Organization: U.S. Department of Health & Human Services
Compound 525685: p-Chlorobenzylidene-cyclohexyl-amine

Chemical compound data from PubChem database. IUPAC Name: 1-(4-chlorophenyl)-N-cyclohexylmethanimine. Molecular Formula: C13H16ClN. Molecular Weight: 221.72. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
The Substance Abuse Prevention and Treatment Block Grant is still Important even with the Expansion of Medicaid

This report looks at SAMHSA Block Grants that serve as a safety net for individuals without health insurance or other resources who seek specialty substance use treatment and prevention services. Under the Affordable Care Act, some of the treatment options that were covered by the SAMHSA Block Grants are likely to be covered by the expansion in Medicaid. Despite the expected increase in Medicaid enrollment, this short report finds that the Substance Abuse Prevention and Treatment Block Grant (SAPT) will still be important in paying for specialty substance abuse treatment for uninsured, low-income individuals.

Tags: medicaid-expansion, prevention-services, samhsa, substance-use-treatment, uninsured-individuals
Organization: U.S. Department of Health & Human Services
Compound 528446: 1-Dodecene, 8-ethyl

Chemical compound data from PubChem database. IUPAC Name: 8-ethyldodec-1-ene. Molecular Formula: C14H28. Molecular Weight: 196.37. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Identification of stem cell units in the terminal end bud and duct
of the mouse mammary gland

The mouse mammary gland may undergo cycles of
proliferation, terminal differentiation, tissue remodeling, and more importantly malignant transformation. Mammary epithelial stem cells and their progeny participate in these processes. Mammary epithelial stem cells are multipotent, exhibit properties of self renewal (up to 7 divisions) and may exist either as long-lived nondividing cells or as proliferating-differentiating cells. The focus of this study was to locate stem cells by identifying them as long-lived, label-retaining mammary epithelial cells
(LRCs) in growth active (developing) or growth static (aged) mammary ducts. Initially, primary epithelial cells were pulse labeled with either fluorescent tracker dye and/or BrdU. Cells were then transplanted into
cleared juvenile syngeneic mammary fat pads and held for 5 weeks or 8 weeks. In this study, we demonstrate that LRCs are stem cells and their
progeny (transitional cells) are arranged as transitional units (TUs). Additionally, TUs are located every 250 ± 75 μm in ducts or in the terminal end bud 200–600 μm in diameter. Molecules
expressed in TUs were Zonula Occludens-1 and α-catenin
proteins which were significantly detected in 75%–91% (P < 0.001) of the LRCs cells that make up the TU. These data suggest that transitional units may be a group of label-retaining stem cells and maybe involved in the developmental or cancer process.

Tags: cell-transplantation, mammary-gland, mouse-model, nih, stem-cells
Organization: U.S. Department of Health & Human Services
2021 NSDUH Data Brief: Differences in Past Year Mental Health among Young Adults

Explore differences between male and female young adults for: any mental illness, serious mental illness, major depressive episodes, mental health treatment, and suicidal behavior. Estimates were based on data from the 2021 National Survey on Drug Use and Health (NSDUH).

Tags: major-depression, mental-health, samhsa, suicidal-ideation, young-adults
Organization: U.S. Department of Health & Human Services
The evolutionary position of nematodes

Background
          The complete genomes of three animals have been sequenced by global research efforts: a nematode worm (Caenorhabditis elegans), an insect (Drosophila melanogaster), and a vertebrate (Homo sapiens). Remarkably, their relationships have yet to be clarified. The confusion concerns the enigmatic position of nematodes. Traditionally, nematodes have occupied a basal position, in part because they lack a true body cavity. However, the leading hypothesis now joins nematodes with arthropods in a molting clade, Ecdysozoa, based on data from several genes.
        
        
          Results
          We tested the Ecdysozoa hypothesis with analyses of more than 100 nuclear protein alignments, under conditions that would expose biases, and found that it was not supported. Instead, we found significant support for the traditional hypothesis, Coelomata. Our result is robust to different rates of sequence change among genes and lineages, different numbers of taxa, and different species of nematodes.
        
        
          Conclusion
          We conclude that insects (arthropods) are genetically and evolutionarily closer to humans than to nematode worms.

Tags: evolutionary-biology, genome-sequencing, nematode-genomics, nih, phylogenetic-analysis
Organization: U.S. Department of Health & Human Services
Airway pressure release ventilation increases cardiac performance in patients with acute lung injury/adult respiratory distress syndrome

Background
          The purpose of the present study is to determine whether airway pressure release ventilation (APRV) can safely enhance hemodynamics in patients with acute lung injury (ALI) and/or adult respiratory distress syndrome (ARDS), relative to pressure control ventilation (PCV).
        
        
          Method
          Patients with severe acute lung injury or ARDS who were managed with inverse-ratio pressure control ventilation, neuromuscular blockade and a pulmonary artery catheter were switched to APRV. Hemodynamic performance, as well as pressor and sedative needs, was assessed after discontinuing neuromuscular blockade
        
        
          Results
          Mean age was 58 ± 9 years (n = 12) and mean Lung Injury Score was 7.6 ± 2.1. Temperature and arterial oxygen tension/fractional inspired oxygen (FiO2) were similar among the patients. Peak airway pressures fell from 38 ± 3 for PCV to 25 ± 3 cmH2O for APRV, and mean pressures fell from 18 ± 3 for PCV to 12 ± 2 cmH2O for APRV. Paralytic use and sedative use were significantly lower with APRV than with PCV. Pressor use decreased substantially with ARPV. Lactate levels remained normal, but decreased on APRV. Cardiac index rose from 3.2 ± 0.4 for PCV to 4.6 ± 0.3 l/min per m2 body surface area (BSA) for APRV, whereas oxygen delivery increased from 997 ± 108 for PCV to 1409 ± 146 ml/min for APRV, and central venous pressure declined from 18 ± 4 for PCV to 12 ± 4 cmH2O for APRV. Urine output increased from 0.83 ± 0.1 for PCV to 0.96 ± 0.12 ml/kg per hour for APRV.
        
        
          Conclusion
          APRV may be used safely in patients with ALI/ARDS, and decreases the need for paralysis and sedation as compared with PCV-inverse ratio ventilation (IRV). APRV increases cardiac performance, with decreased pressor use and decreased airway pressure, in patients with ALI/ARDS.

Tags: acute-lung-injury, airway-pressure-release, ards-ventilation, hemodynamic-performance, nih
Organization: U.S. Department of Health & Human Services
Change of dopamine receptor mRNA expression in lymphocyte of schizophrenic patients

Background
          Though the dysfunction of central dopaminergic system has been proposed, the etiology or pathogenesis of schizophrenia is still uncertain partly due to limited accessibility to dopamine receptor. The purpose of this study was to define whether or not the easily accessible dopamine receptors of peripheral lymphocytes can be the peripheral markers of schizophrenia.
        
        
          Results
          44 drug-medicated schizophrenics for more than 3 years, 28 drug-free schizophrenics for more than 3 months, 15 drug-naïve schizophrenic patients, and 31 healthy persons were enrolled. Sequential reverse transcription and quantitative polymerase chain reaction of the mRNA were used to investigate the expression of D3 and D5 dopamine receptors in peripheral lymphocytes. The gene expression of dopamine receptors was compared in each group. After taking antipsychotics in drug-free and drug-naïve patients, the dopamine receptors of peripheral lymphocytes were sequentially studied 2nd week and 8th week after medication.
          In drug-free schizophrenics, D3 dopamine receptor mRNA expression of peripheral lymphocytes significantly increased compared to that of controls and drug-medicated schizophrenics, and D5 dopamine receptor mRNA expression increased compared to that of drug-medicated schizophrenics. After taking antipsychotics, mRNA of dopamine receptors peaked at 2nd week, after which it decreases but the level was above baseline one at 8th week. Drug-free and drug-naïve patients were divided into two groups according to dopamine receptor expression before medications, and the group of patients with increased dopamine receptor expression had more severe psychiatric symptoms.
        
        
          Conclusions
          These results reveal that the molecular biologically-determined dopamine receptors of peripheral lymphocytes are reactive, and that increased expression of dopamine receptor in peripheral lymphocyte has possible clinical significance for subgrouping of schizophrenis.

Tags: antipsychotic-medication, dopamine-receptors, gene-expression, nih, schizophrenia-lymphocytes
Organization: U.S. Department of Health & Human Services
2014 CMHS Uniform Reporting System (URS) Table for Maryland

2014 Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for Maryland. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, maryland, mental-health-services, outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Adenovirus type 7 associated with severe and fatal acute lower respiratory infections in Argentine children

Background
          Adenoviruses are the second most prevalent cause of acute lower respiratory infection of viral origin in children under four years of age in Buenos Aires, Argentina. The purpose of this study was to analyze the clinical features and outcome of acute lower respiratory infection associated with different adenovirus genotypes in children.
        
        
          Methods
          Twenty-four cases of acute lower respiratory infection and adenovirus diagnosis reported in a pediatric unit during a two-year period were retrospectively reviewed. Adenovirus was detected by antigen detection and isolation in HEp-2 cells. Adenovirus DNA from 17 isolates was studied by restriction enzyme analysis with Bam HI and Sma I.
        
        
          Results
          Subgenus b was found in 82.3% of the cases, and subgenus c in 17.7%. Within subgenus b, only genotype 7 was detected, with genomic variant 7h in 85.7% (12/14) and genomic variant 7i in 14.3% (2/14).
          Mean age was 8.8 ±; 6 months, and male to female ratio was 3.8: 1. At admission, pneumonia was observed in 71% of the cases and bronchiolitis in 29%. Malnutrition occurred in 37% of the cases; tachypnea in 79%; chest indrawing in 66%; wheezing in 58%; apneas in 16%; and conjunctivitis in 29%. Blood cultures for bacteria and antigen detection of other respiratory viruses were negative.
          During hospitalization, fatality rate was 16.7% (4 /24). Of the patients who died, three had Ad 7h and one Ad 7i. Thus, fatality rate for adenovirus type 7 reached 28.6% (4/14).
        
        
          Conclusions
          These results show the predominance of adenovirus 7 and high lethality associated with the genomic variants 7h and 7i in children hospitalized with acute lower respiratory infection.

Tags: adenovirus-type-7, argentina, nih, pediatric-respiratory-infection, viral-genotyping
Organization: U.S. Department of Health & Human Services
A follow-up to "Anti-cytokine therapy in chronic destructive arthritis" by Wim B van den Berg

In recent years, the effectiveness of anti-TNF therapy in treating rheumatoid arthritis (RA) has become apparent. While trials of IL-1 receptor antagonist in RA have been encouraging, it clearly is more difficult to target two molecules (IL-1 α and β) than one (TNF-α). In his review article, Professor Wim van den Berg argues that both TNF-α and IL-1 must be blocked in RA and that although TNF is clearly a potent inflammatory molecule, the dominant cytokine in the subsequent degradation of the joint tissue is IL-1. This commentary discusses his hypothesis in light of animal studies and the limitations of the conclusions that can be drawn from them. More broadly, it discusses the biology of TNF-α and IL-1 and suggests explanations of why TNF-α is a pivotal cytokine in this disease.

Tags: anti-tnf-therapy, cytokine-therapy, il-1-antagonist, nih, rheumatoid-arthritis
Organization: U.S. Department of Health & Human Services
Compound 525646: N,N-Dimethyl-N'-phenyl-p-chlorobenzamidine

Chemical compound data from PubChem database. IUPAC Name: 4-chloro-N,N-dimethyl-N'-phenylbenzenecarboximidamide. Molecular Formula: C15H15ClN2. Molecular Weight: 258.74. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Child and Family Services Reviews Update Volume 14, Issue 2, April 2020

This issue of Child and Family Services Reviews Update contains the following sections: CB Response to COVID-19 Pandemic, CFSR Technical Bulletin #11, Enhancements to the Data Indicator Visualizations, State Data Profiles Released, ACYF-CB-PI-20-02— State Guidance on FY 2021 APSR, Status of Approved PIPs, and PIP Evaluation During Non-Overlapping Data Periods.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: child, family, policy, reporting, scope
Organization: U.S. Department of Health & Human Services
Lactate: A key metabolite in the intercellular metabolic interplay

Most physicians involved in intensive care consider lactate solely as a deleterious metabolite, responsible for high morbidity and bad prognosis in severe patients. For the physiologist, however, lactate is a key metabolite, alternatively produced or consumed. Many studies in the literature have infused animals or humans with exogenous lactate, demonstrating its safety and usefulness, but the bad reputation of lactate is still widespread. The metabolic meaning of glucose–lactate cycling exceeds its initial role described by Cori and Cori. According to recent works concerning lactate, it can be predicted that a new role as a therapeutic agent will arise for this metabolite.

Tags: cori-cycle, intercellular-metabolism, lactate-metabolism, metabolic-shuttle, nih
Organization: U.S. Department of Health & Human Services
Drug Abuse Warning Network, 2010

Includes the annual report with national estimates of drug-related visits to hospital emergency departments (EDs) for 2010, based on data from the Drug Abuse Warning Network (DAWN); the methodology report, updated for 2010; a glossary of terms updated for 2010, and a guide to the DAWN ED trend tables (data tables). .

Tags: adverse-drug-events, drug-overdose, emergency-department, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
National Admissions to Substance Abuse Treatment Services - The Treatment Episode Data Set (TEDS) 1992-2001

This report presents results from the Treatment Episode Data Set (TEDS) for 2001 and trend data for 1992-2001. The report provides information on the demographic and substance abuse characteristics of the 1.7 million people admitted to treatment for abuse of alcohol and drugs in 2001 to facilities that report to individual state administrative data systems.

Tags: alcohol-drug-abuse, samhsa, substance-abuse-treatment, teds-data, treatment-episode-data
Organization: U.S. Department of Health & Human Services