AndreaBozzo/ceres-open-data-index huggingface dataset:
In-vivo evaluation of simultaneous administration of incompatible
		  drugs in a central venous catheter with a decreased port to port distance

Background:
          Multilumen catheters are commonly used in critically ill children.
				Their use, however, is associated with significant morbidity. We studied the
				simultaneous administration of incompatible drugs using a new triple-lumen
				catheter with decreased length and port to port distances.
        
        
          Methods:
          Ten domestic swine, 10–20 kg in weight, were divided into two
				groups of five. Total parenteral nutrition was administered through the distal
				port and phenytoin was administered as a bolus and as an infusion in each
				group. Samples were taken from two sites during the bolus and at 1, 5, and
				15 min during phenytoin infusion. Histograms were generated for particle size
				and concentration. Samples were also examined under the microscope for
				particles.
        
        
          Results:
          Histograms of particle size did not show any alteration of the
				histogram that would suggest particle size > 2 μm in diameter in the
				study or control samples. No particles were identified by phase microscope,
				light microscope, or Wright stain smear.
        
        
          Conclusions:
          The use of a triple-lumen catheter with a distance of 0.4cm
				between the proximal port and the medial port and 1.3 cm between the medial port
				and the distal port, for the in vivo simultaneous administration of
				incompatible solutions does not result in precipitates large enough to cause
				adverse clinical effects.

Tags: central-venous-catheter, drug-incompatibility, nih, pediatric-critical-care, total-parenteral-nutrition
Organization: U.S. Department of Health & Human Services
Compound 525247: N''-(4-ethoxy-phenyl)-N,N,N',N'-tetramethyl-guanidine

Chemical compound data from PubChem database. IUPAC Name: 2-(4-ethoxyphenyl)-1,1,3,3-tetramethylguanidine. Molecular Formula: C13H21N3O. Molecular Weight: 235.33. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2014 CMHS Uniform Reporting System (URS) Table for Oregon

2014 Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for Oregon. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-data, mental-health-services, noms-measures, oregon-mental-health, samhsa
Organization: U.S. Department of Health & Human Services
Compound 527367: 18,22-Dimethyl-tetratriacontyl cyanide

Chemical compound data from PubChem database. IUPAC Name: 19,23-dimethylpentatriacontanenitrile. Molecular Formula: C37H73N. Molecular Weight: 532.0. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Expression of monolysocardiolipin acyltransferase activity is regulated in concert with the level of cardiolipin and cardiolipin biosynthesis in the mammalian heart

Background
          Monolysocardiolipin acyltransferase (MLCL AT) catalyzes the acylation of monolysocardiolipin to cardiolipin in mammalian tissues. We previously reported that cardiac cardiolipin levels, MLCL AT and cardiolipin synthase activities were all elevated in rats made hyperthyroid by thyroxine treatment. In this study, we examined if cardiac mitochondrial MLCL AT activity was dependent upon the biosynthesis and level of cardiolipin in the heart. Rat heart mitochondrial MLCL AT activity was determined under conditions in which the levels of cardiac cardiolipin and cardiolipin synthase activity were either reduced or unaltered using four different disease models in the rat. In addition, these parameters were examined in a murine model of cardiac cell differentiation.
        
        
          Results
          In rats made hypothyroid by treatment with 6-n-propyl-2-thiouracil in the drinking water for 34 days, cardiac cardiolipin content was decreased 29% (p < 0.025) and this was associated with a 32% decrease (p < 0.025) in cardiolipin synthase and a 35% reduction (p < 0.025) in MLCL AT activities. Streptozotocin-induced diabetes or hyperinsulinemia in rats did not affect cardiac cardiolipin content nor MLCL AT and cardiolipin synthase activities. Finally, cardiolipin content, MLCL AT and cardiolipin synthase activities were unaltered during murine P19 teratocarcinoma cell differentiation into cardiac myocytes. In all models, phospholipase A2 activities were unaltered compared with controls.
        
        
          Conclusion
          We propose a general model in which the expression of MLCL AT activity is regulated in concert with the biosynthesis and level of cardiolipin in the heart.

Tags: acyltransferase-activity, cardiolipin-synthesis, mitochondrial-function, nih, thyroid-hormones
Organization: U.S. Department of Health & Human Services
Magnetic stimulation for non-homogeneous biological structures

Background
          Magnetic stimulation has gained relatively wide application in studying nervous system structures. This technology has the advantage of reduced excitation of sensory nerve endings, and hence results in quasi-painless action. It has become clinically accepted modality for brain stimulation. However, theoretical and practical solutions for assessment of induced current distribution need more detailed and accurate consideration.
          Some possible analyses are proposed for distribution of the current induced from excitation current contours of different shape and disposition. Relatively non-difficult solutions are shown, applicable for two- and three-dimensional analysis.
        
        
          Methods
          The boundary conditions for field analysis by the internal Dirichlet problem are introduced, based on the vector potential field excited by external current coils. The feedback from the induced eddy currents is neglected. Finite element modeling is applied for obtaining the electromagnetic fields distribution in a non-homogeneous domain.
        
        
          Results
          The distributions were obtained in a non-homogeneous structure comprised of homogeneous layers. A tendency was found of the induced currents to follow paths in lower resistivity layers, deviating from the expected theoretical course for a homogeneous domain. Current density concentrations occur at the boundary between layers, suggesting the possibility for focusing on, or predicting of, a zone of stimulation.
        
        
          Conclusion
          The theoretical basis and simplified approach for generation of 3D FEM networks for magnetic stimulation analysis are presented, applicable in non-homogeneous and non-linear media. The inconveniences of introducing external excitation currents are avoided. Thus, the possibilities are improved for analysis of distributions induced by time-varying currents from contours of various geometry and position with respect to the medium.

Tags: finite-element-modeling, induced-current, magnetic-stimulation, nervous-system, nih
Organization: U.S. Department of Health & Human Services
National Directory of Drug and Alcohol Abuse Treatment Facilities - 1975

The National Directory of Drug and Alcohol Abuse Treatment Programs 1975 lists federal, state, local, and private facilities that provide substance abuse treatment services. The directory includes treatment facilities that are licensed, certified, or otherwise approved for inclusion in the directory by their state substance abuse agencies and that responded to the 1974 National Survey of Substance Abuse Treatment Services (N-SSATS). The information about each facility that appears in this directory was provided by that facility in response to the 1974 N-SSATS. The Substance Abuse and Mental Health Services Administration (SAMHSA) conducts the N-SSATS annually.

Tags: 1974-n-ssats, alcohol-abuse-treatment, samhsa, substance-abuse-treatment, treatment-facility-directory
Organization: U.S. Department of Health & Human Services
2020 Uniform Reporting System (URS) Table For Federated States Of Micronesia

This is the 2020 Uniform Reporting System (URS) Output Tables for Federated States Of Micronesia. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: mental-health-services, micronesia, national-outcome-measures, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
Efficacy of SSH PCR in isolating differentially expressed genes

Background
          Suppression Subtractive Hybridization PCR (SSH PCR) is a sophisticated cDNA subtraction method to enrich and isolate differentially expressed genes. Despite its popularity, the method has not been thoroughly studied for its practical efficacy and potential limitations.
        
        
          Results
          To determine the factors that influence the efficacy of SSH PCR, a theoretical model, under the assumption that cDNA hybridization follows the ideal second kinetic order, is proposed. The theoretical model suggests that the critical factor influencing the efficacy of SSH PCR is the concentration ratio (R) of a target gene between two cDNA preparations. It preferentially enriches "all or nothing" differentially expressed genes, of which R is infinite, and strongly favors the genes with large R. The theoretical predictions were validated by our experiments. In addition, the experiments revealed some practical limitations that are not obvious from the theoretical model. For effective enrichment of differentially expressed genes, it requires fractional concentration of a target gene to be more than 0.01% and concentration ratio to be more than 5 folds between two cDNA preparations.
        
        
          Conclusion
          Our research demonstrated theoretical and practical limitations of SSH PCR, which could be useful for its experimental design and interpretation.

Tags: cdna-subtraction, differential-expression, gene-expression, nih, ssh-pcr
Organization: U.S. Department of Health & Human Services
Title IV-E Adoption Assistance

The Adoption Assistance Program provides funds to states and participating territories and tribes to facilitate the timely placement of children, whose special needs or circumstances would otherwise make them difficult to place with adoptive families. The program is annually appropriated and funding is awarded as an open-ended entitlement grant. Funding is contingent upon an approved title IV-E plan to administer or supervise the administration of the program.  The program operates in 50 states, the District of Columbia, Puerto Rico, the U.S. Virgin Islands, and federally recognized Tribes with approved title IV-E plans.

Matching funds are provided based on the expenditures made on behalf of children determined eligible for the program.  Funds are available for a one-time payment to assist with the costs of adopting a child as well as for monthly subsidies to adoptive families who enter into an adoption assistance agreement to assist with the care of the eligible child.  The program provides federal matching funds at the Federal Medical Assistance Percentage, ranging from 50 to 83 percent, for adoption assistance payments, depending on the per capita income of the state or Tribe. Additionally, funds are available for: administrative costs to manage the program; training staff and adoptive parents; adoptive parent recruitment; and other related expenses. Allowable administrative activities are matched at 50 percent and allowable training costs at 75 percent.  The Title IV-E agency must submit quarterly reports of estimated and actual program expenditures and the average monthly number of children served.

FY 2024: $4.7 billion

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: adoption, child, cross, grant, policy
Organization: U.S. Department of Health & Human Services
Illinois: 2011-2012 NSDUH

This report presents Illinois\'s estimates for 25 measures of substance use and mental health based on the combined 2011 and 2012 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided by State and for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: illinois-nsduh, major-depressive-episode, mental-health, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
2024 National Directory of Mental Health Treatment Facilities

TheNational Directory of Mental Health Treatment Facilities - 2024is a listing of federal, state, and local government facilities and private facilities that provide mental health treatment services. It includes treatment facilities that responded to the 2023 National Substance Use and Mental Health Services Survey (N-SUMHSS). The information about each facility that appears in this Directory was provided by that facility in response to the 2023 N-SUMHSS. The N-SUMHSS is conducted annually by the Substance Abuse and Mental Health Services Administration (SAMHSA). The 2024 Directory is available in PDF and Excel formats.The Directory is ordered alphabetically by state, by city within each state, and by facility name within each city. Each facility listing includes codes that represent the services offered and other features of the facility, including codes that indicate services for hearing impaired and non-English-speaking clients. Codes are defined in a key shown on pages v-x of the PDF file and as a separate tab on the Excel version. Please note services offered by a particular facility may change over time. It is suggested to verify the information in this Directory when contacting a facility.

Tags: behavioral-health, facility-directory, mental-health-facilities, samhsa, treatment-services
Organization: U.S. Department of Health & Human Services
Compound 525154: Glycerol-hexapropylene glycol ether, triacetate

Chemical compound data from PubChem database. IUPAC Name: 2-[2-[2-[2-[2-[2-(2,3-diacetyloxypropoxy)propoxy]propoxy]propoxy]propoxy]propoxy]propyl acetate. Molecular Formula: C27H50O12. Molecular Weight: 566.7. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Dear Colleague Letter on Best Practices for Adhering to Early and Periodic Screening, Diagnostic, and Treatment Requirements

On November 22, 2024, the Children’s Bureau (CB) within the Administration on Children, Youth, and Families (ACYF) released a Dear Colleague Letter (DCL) pertaining to the recent guidance issued by the Center for Medicaid and CHIP Services (CMS) entitled, Best Practices for Adhering to Early and Periodic Screening, Diagnostic, and Treatment (EPSDT) Requirements
  
  

 (PDF).

The DCL emphasizes the importance of the new CMS guidance, specifically for child welfare leaders seeking to address health care needs, both as a strategy for preventing entry into the child welfare system, as well as for addressing the needs of children and youth in foster care. The DCL also provides suggested actions for child welfare leaders to serve as valuable thought partners to their Medicaid counterparts in thinking through the benefits of specific Medicaid services across systems.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: care, guidance, instruction, medicaid, policy
Organization: U.S. Department of Health & Human Services
Compound 525105: 2,3-Dichloropropyl butyrate

Chemical compound data from PubChem database. IUPAC Name: 2,3-dichloropropyl butanoate. Molecular Formula: C7H12Cl2O2. Molecular Weight: 199.07. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2023 Uniform Reporting System (URS) Table For Alabama

This is the 2023 Uniform Reporting System (URS) Output Tables for Alabama. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: alabama-mental-health, mental-health-services, national-outcome-measures, samhsa, substance-abuse-treatment
Organization: U.S. Department of Health & Human Services
Maine 2016 Potential Areas for Addressing Service Gaps for Opioid Treatment

The purpose of the medication-assisted treatment (MAT) facility maps is to identify areas on a state-by-state basis that may be potentially underserved by existing treatment facilities. The maps are created with a methodology that seeks to include the highest potential need areas from individual counties so that county-level stakeholders are also informed. The maps are meant to be used as a tool for policy makers to determine potentially underserved areas—not as a definitive representation of these areas.

Tags: maine, mat-access, opioid-treatment, samhsa, service-gap-analysis
Organization: U.S. Department of Health & Human Services
Towards understanding the first genome sequence of a crenarchaeon by genome annotation using clusters of orthologous groups of proteins (COGs)

Background:
          Standard archival sequence databases have not been designed as tools for genome annotation and are far from being optimal for this purpose. We used the database of Clusters of Orthologous Groups of proteins (COGs) to reannotate the genomes of two archaea, Aeropyrum pernix, the first member of the Crenarchaea to be sequenced, and Pyrococcus abyssi.
        
        
          Results:
          A. pernix and P. abyssi proteins were assigned to COGs using the COGNITOR program; the results were verified on a case-by-case basis and augmented by additional database searches using the PSI-BLAST and TBLASTN programs. Functions were predicted for over 300 proteins from A. pernix, which could not be assigned a function using conventional methods with a conservative sequence similarity threshold, an approximately 50% increase compared to the original annotation. A. pernix shares most of the conserved core of proteins that were previously identified in the Euryarchaeota. Cluster analysis or distance matrix tree construction based on the co-occurrence of genomes in COGs showed that A. pernix forms a distinct group within the archaea, although grouping with the two species of Pyrococci, indicative of similar repertoires of conserved genes, was observed. No indication of a specific relationship between Crenarchaeota and eukaryotes was obtained in these analyses. Several proteins that are conserved in Euryarchaeota and most bacteria are unexpectedly missing in A. pernix, including the entire set of de novo purine biosynthesis enzymes, the GTPase FtsZ (a key component of the bacterial and euryarchaeal cell-division machinery), and the tRNA-specific pseudouridine synthase, previously considered universal. A. pernix is represented in 48 COGs that do not contain any euryarchaeal members. Many of these proteins are TCA cycle and electron transport chain enzymes, reflecting the aerobic lifestyle of A. pernix.
        
        
          Conclusions:
          Special-purpose databases organized on the basis of phylogenetic analysis and carefully curated with respect to known and predicted protein functions provide for a significant improvement in genome annotation. A differential genome display approach helps in a systematic investigation of common and distinct features of gene repertoires and in some cases reveals unexpected connections that may be indicative of functional similarities between phylogenetically distant organisms and of lateral gene exchange.

Tags: archaea-proteins, crenarchaeon-genome, genome-annotation, nih, protein-function
Organization: U.S. Department of Health & Human Services
Clinical ethics revisited

A decade ago, we reviewed the field of clinical ethics; assessed its progress in research, education, and ethics committees and consultation; and made predictions about the future of the field. In this article, we revisit clinical ethics to examine our earlier observations, highlight key developments, and discuss remaining challenges for clinical ethics, including the need to develop a global perspective on clinical ethics problems.

Tags: clinical-ethics, ethical-consultation, medical-ethics, nih
Organization: U.S. Department of Health & Human Services
2014 CMHS Uniform Reporting System (URS) Table for Florida

2014 Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for Florida. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: florida-mental-health, mental-health-services, noms-measures, samhsa, substance-abuse-treatment
Organization: U.S. Department of Health & Human Services
2018 Uniform Reporting System (URS) Table for New York

This is the 2018 Uniform Reporting System (URS) Output Tables for New York. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-data, mental-health-services, new-york-state, noms-measures, samhsa
Organization: U.S. Department of Health & Human Services
Compound 525272: N'-(3-methyl-phenyl)-N,N-dimethyl-acetamidine

Chemical compound data from PubChem database. IUPAC Name: N,N-dimethyl-N'-(3-methylphenyl)ethanimidamide. Molecular Formula: C11H16N2. Molecular Weight: 176.26. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services