AndreaBozzo/ceres-open-data-index huggingface dataset:
Introduction to the National Mental Health Services Survey, 2010

This is a short report introducing the National Mental Health Services Survey (N-MHSS) for 2010. N-MHSS is conducted by the Substance Abuse and Mental Health Services Administration (SAMHSA) and is an annual survey of all known public and private mental health treatment facilities in the United States. N-MHSS is used to collect basic data on the number, location, and characteristics of specialty mental health treatment facilities and the persons they serve throughout the 50 states, the District of Columbia, and other U.S. jurisdictions.

Tags: behavioral-health, mental-health-services, national-survey, samhsa, treatment-facilities
Organization: U.S. Department of Health & Human Services
Compound 525409: Hexane, 1-[(1-methylethyl)thio]-

Chemical compound data from PubChem database. IUPAC Name: 1-propan-2-ylsulfanylhexane. Molecular Formula: C9H20S. Molecular Weight: 160.32. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Washington 2016 Potential Areas for Addressing Service Gaps for Opioid Treatment

The purpose of the medication-assisted treatment (MAT) facility maps is to identify areas on a state-by-state basis that may be potentially underserved by existing treatment facilities. The maps are created with a methodology that seeks to include the highest potential need areas from individual counties so that county-level stakeholders are also informed. The maps are meant to be used as a tool for policy makers to determine potentially underserved areas—not as a definitive representation of these areas.

Tags: medication-assisted-treatment, opioid-treatment, samhsa, service-gap-analysis, washington-state
Organization: U.S. Department of Health & Human Services
Internet hand x-rays: A comparison of joint space narrowing and erosion scores (Sharp/Genant) of plain versus digitized x-rays in rheumatoid arthritis patients

Background
          The objective of the study is to examine the reliability of erosion and joint space narrowing scores derived from hand x-rays posted on the Internet compared to scores derived from original plain x-rays.
        
        
          Methods
          Left and right x-rays of the hands of 36 patients were first digitized and then posted in standard fashion to a secure Internet website. Both the plain and Internet x-rays were scored for erosions and joint space narrowing using the Sharp/Genant method. All scoring was completed in a blind and randomized manner. Agreement between plain and Internet x-ray scores was calculated using Lin's concordance correlations and Bland-Altman graphical representation.
        
        
          Results
          Erosion scores for plain x-rays showed almost perfect concordance with x-rays read on the Internet (concordance 0.887). However, joint space narrowing scores were only "fair" (concordance 0.365). Global scores demonstrated substantial concordance between plain and Internet readings (concordance 0.769). Hand x-rays with less disease involvement showed a tendency to be scored higher on the Internet versions than those with greater disease involvement. This was primarily evident in the joint space narrowing scores.
        
        
          Conclusions
          The Internet represents a valid medium for displaying and scoring hand x-rays of patients with RA. Higher scores from the Internet version may be related to better viewing conditions on the computer screen relative to the plain x-ray viewing, which did not include magnifying lens or bright light. The capability to view high quality x-rays on the Internet has the potential to facilitate information sharing, education, and encourage collaborative studies.

Tags: hand-x-rays, joint-space-narrowing, nih, rheumatoid-arthritis, sharp-genant-score
Organization: U.S. Department of Health & Human Services
Bone loss: Factors that regulate osteoclast differentiation - an update

Osteoclast activation is a critical cellular process for pathological bone resorption, such as erosions in rheumatoid arthritis (RA) or generalized bone loss. Among many factors triggering excessive osteoclast activity, cytokines such as IL-1 or tumour necrosis factor (TNF)-α play a central role. New members of the TNF receptor ligand family (namely receptor activator of nuclear factor-κB [RANK] and RANK ligand [RANKL]) have been discovered whose cross-interaction is mandatory for the differentiation of osteoclasts from hemopoietic precursors, in both physiological and pathological situations. Osteoprotegerin, a decoy receptor which blocks this interaction, decreases osteoclast activity and could have a fascinating therapeutic potential in conditions associated with upregulated bone resorption.

Tags: bone-resorption, nih, osteoclast-differentiation, osteoprotegerin, rank-rankl-signaling
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Tennessee, 2015

This is a behavioral health report for the state of Tennessee. The report utilizes data from the National Survey on Drug Use and Health (NSDUH), and the Uniform Reporting System. The topics addressed in the report include youth substance use, youth mental health and treatment, mental health and treatment, substance use and substance use treatment.

Tags: mental-health-treatment, nsduh-data, samhsa, tennessee-behavioral-health, youth-substance-use
Organization: U.S. Department of Health & Human Services
Compound 525177: Octapropylene glycol, monoallyl ether, acetate

Chemical compound data from PubChem database. IUPAC Name: 1-[1-[1-[1-[1-[1-[1-(1-prop-2-enoxypropan-2-yloxy)propan-2-yloxy]propan-2-yloxy]propan-2-yloxy]propan-2-yloxy]propan-2-yloxy]propan-2-yloxy]propan-2-yl acetate. Molecular Formula: C29H56O10. Molecular Weight: 564.7. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
The Myocardial Ischemia Reduction with Acute Cholesterol Lowering (MIRACL) trial: a new frontier for statins?

The Myocardial Ischemia Reduction with Acute Cholesterol Lowering (MIRACL) Trial tested the hypothesis that intensive lowering of cholesterol with atorvastatin (80 mg/day) initiated 24-96 h after an acute coronary syndrome would, over 4 months, reduce the incidence of the composite endpoint of death, nonfatal infarction, resuscitated cardiac arrest, and recurrent symptomatic myocardial ischemia with new objective symptoms requiring emergency rehospitalization. This primary composite endpoint was reduced from 17.4% to 14.8% (P = 0.048) among the 3086 patients enrolled. The results of MIRACL suggest that patients with acute coronary syndromes should begin to receive this treatment before leaving hospital, irrespective of baseline levels of low-density lipoprotein-cholesterol.

Tags: acute-coronary-syndrome, atorvastatin-treatment, cholesterol-lowering, myocardial-ischemia, nih
Organization: U.S. Department of Health & Human Services
2010 State Profile — Montana

This state profile includes data from facilities in Montana that reported to N-SSATS for the survey reference date March 31, 2010. Data were collected on the location, characteristics, services offered, and number of clients in treatment at alcohol and drug abuse treatment facilities (both public and private) in Montana. In Montana, 53 substance abuse treatment facilities were included in the 2010 N-SSATS, reporting that there were 3,114 clients in substance abuse treatment on March 31, 2010. The survey response rate in Montana was 91.2%.

Tags: alcohol-drug-abuse, montana, n-ssats, samhsa, substance-abuse-treatment
Organization: U.S. Department of Health & Human Services
Risk and Protective Factors Tables (Standard Errors and P Values) - 3.1 to 3.25

These detailed tables present standard errors for totals and prevalence estimates of risk and protective factors regarding substance use from the 2011 National Survey on Drug Use and Health (NSDUH). The factors include perceptions of 1) risk of substance use, 2) availability of substances, 3) parental disapproval of youth substance use, 4) peer substance use. These factors include measures of delinquent behavior, religious involvement, exposure to prevention messages, and parental involvement. Standard errors are provided by age group, gender, race/ethnicity, geographic area, and youth substance use behavior. Standard errors are provided for both 2011 and 2010.

Tags: nsduh-2011, protective-factors, samhsa, substance-use-risk, youth-substance-use
Organization: U.S. Department of Health & Human Services
Compound 525448: 3-Methyl-2,4-dithiahexane

Chemical compound data from PubChem database. IUPAC Name: 1-ethylsulfanyl-1-methylsulfanylethane. Molecular Formula: C5H12S2. Molecular Weight: 136.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 525352: 2,2-Dimethyl-3-thiaoctane

Chemical compound data from PubChem database. IUPAC Name: 1-tert-butylsulfanylpentane. Molecular Formula: C9H20S. Molecular Weight: 160.32. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 525492: 5,6-Dimethyl-4-thia-1-heptene

Chemical compound data from PubChem database. IUPAC Name: 2-methyl-3-prop-2-enylsulfanylbutane. Molecular Formula: C8H16S. Molecular Weight: 144.28. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Interaction of neuronal nitric oxide synthase with alpha

Background
          The C-terminal four amino acids (GEEV) of human α1A-adrenergic receptors (ARs) have been reported to interact with the PDZ domain of neuronal nitric oxide synthase (nNOS) in a yeast two-hybrid system. The other two α1-AR subtypes have no sequence homology in this region, raising the possibility of subtype-specific protein-protein interactions.
        
        
          Results
          We used co-immunoprecipitation and functional approaches with epitope-tagged α1-ARs to examine this interaction and the importance of the C-terminal tail. Following co-transfection of HEK-293 cells with hexahistidine/Flag (HF)-tagged α1A-ARs and nNOS, membranes were solubilized and immunoprecipitated with anti-FLAG affinity resin or anti-nNOS antibodies. Immunoprecipitation of HFα1A-ARs resulted in co-immunoprecipitation of nNOS and vice versa, confirming that these proteins interact. However, nNOS also co-immunoprecipitated with HFα1B- and HFα1D-ARs, suggesting that the interaction is not specific to the α1A subtype. In addition, nNOS co-immunoprecipitated with each of the three HFα1-AR subtypes which had been C-terminally truncated, suggesting that this interaction does not require the C-tails; and with Flag-tagged β1- and β2-ARs. Treatment of PC12 cells expressing HFα1A-ARs with an inhibitor of nitric oxide formation did not alter norepinephrine-mediated activation of mitogen activated protein kinases, suggesting nNOS is not involved in this response.
        
        
          Conclusions
          These results show that nNOS does interact with full-length α1A-ARs, but that this interaction is not subtype-specific and does not require the C-terminal tail, raising questions about its functional significance.

Tags: adrenergic-receptors, co-immunoprecipitation, nih, nitric-oxide-synthase, protein-interactions
Organization: U.S. Department of Health & Human Services
Compound 525183: Tetraethylene glycol, monoallyl ether, acetate

Chemical compound data from PubChem database. IUPAC Name: 2-[2-[2-(2-prop-2-enoxyethoxy)ethoxy]ethoxy]ethyl acetate. Molecular Formula: C13H24O6. Molecular Weight: 276.33. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Activation of the Fas/Fas ligand pathway in hypertensive renal disease in Dahl/Rapp rats

Background
          Hypertensive nephrosclerosis is the second most common cause of end-stage renal failure in the United States. The mechanism by which hypertension produces renal failure is incompletely understood. Recent evidence demonstrated that an unscheduled and inappropriate increase in apoptosis occurred in the Dahl/Rapp rat, an inbred strain of rat that uniformly develops hypertension and hypertensive nephrosclerosis; early correction of the hypertension prevents the renal injury. The present study examined the role of the Fas/FasL pathway in this process.
        
        
          Methods
          Young male Dahl/Rapp salt-sensitive (S) and Sprague-Dawley rats were fed diets that contained 0.3% or 8.0% NaCl diets. Kidneys were examined at days 7 and 21 of the study.
        
        
          Results
          An increase in Fas and FasL expression was observed in glomerular and tubular compartments of kidneys of hypertensive S rats, whereas dietary salt did not change expression of either of these molecules in normotensive Sprague-Dawley rats. Associated with this increase was cleavage of Bid and activation of caspase-8, the initiator caspase in this apoptotic pathway, by day 21 of the study.
        
        
          Conclusions
          Augmented expression of apoptotic signaling by the Fas/FasL pathway occurred during development of end-stage renal failure in this model of hypertensive nephrosclerosis.

Tags: dahl-rapp-rats, fas-fasl-pathway, hypertensive-nephrosclerosis, nih, renal-disease
Organization: U.S. Department of Health & Human Services
Outcome of major cardiac injuries at a Canadian trauma center

Background
          Canadian trauma units have relatively little experience with major cardiac trauma (disruption of a cardiac chamber) so injury outcome may not be comparable to that reported from other countries. We compared our outcomes to those of other centers.
        
        
          Methods
          Records of patients suffering major cardiac trauma over a nine-year period were reviewed. Factors predictive of outcome were analyzed.
        
        
          Results
          Twenty-seven patients (11 blunt and 16 penetrating) with major cardiac trauma were evaluated. Injury severity scores (ISS) were similar for blunt (49.6 ± 16.6) and penetrating (39.5 ± 21.6, p = 0.20) injuries. Five of 11 blunt trauma patients, and 9 of 16 penetrating trauma patients, had detectable vital signs on hospital arrival (p = 0.43). Ten patients underwent emergency department thoracotomy and 11 patients had cardiac repair in the operating theatre. Eleven patients survived and 16 died. Survivors had a lower ISS (33.7 ± 15.4) than non-survivors (50.4 ± 20.4; p = 0.03). Two of 11 blunt trauma patients and 9 of 16 penetrating trauma patients survived (p = 0.06). Eleven of 14 patients with detectable vital signs survived; all 13 without detectable vital signs died (p = 0.00003). Ten of eleven patients treated in the operating theatre survived, while only one of the other 16 patients survived (p = 0.00002).
        
        
          Conclusions
          Patients with major cardiac injuries and detectable vital signs on hospital arrival can be salvaged by prompt surgical intervention in the operating theatre. Major cardiac injuries are infrequently encountered at our center but patient survival is comparable to that reported from trauma units in other countries.

Tags: cardiac-trauma, emergency-thoracotomy, injury-severity-score, nih, trauma-outcomes
Organization: U.S. Department of Health & Human Services
Which treatment for low back pain? A factorial randomised controlled trial comparing intravenous analgesics with oral analgesics in the emergency department and a centrally acting muscle relaxant with placebo over three days [ISRCTN09719705]

Background
          About two thirds of adults suffer from backpain at some time during their life. In the emergency room many patients with acute back pain are treated with intravenous non-steroidal analgesics. Whether this treatment is superior to oral administration of non-steroidal analgesics is unknown. Intravenous administration, however, requires considerable amounts of resources and accounts for high workload in busy clinics. In the further course centrally acting muscle relaxants are prescribed but the effectiveness remains unclear. The objective of this study is on the one hand to compare the effectiveness of intravenous with oral non-steroidal analgesics for acute treatment and on the other hand to compare the effectiveness of a centrally active muscle relaxant with placebo given for three days after presentation to the ED (emergency department).
        
        
          Methods/Design
          This study is intended as a randomised controlled factorial trial mainly for two reasons: (1) the sequence of treatments resembles the actual proceedings in every-day clinical practice, which is important for the generalisability of the results and (2) this design allows to take interactions between the two sequential treatment strategies into account. There is a patient preference arm included because patients preference is an important issue providing valuable information: (1) it allows to assess the interaction between desired treatment and outcome, (2) results can be extrapolated to a wider group while (3) conserving the advantages of a fully randomised controlled trial.
        
        
          Conclusion
          We hope to shed more light on the effectiveness of treatment modalities available for acute low back pain.

Tags: analgesics-trial, emergency-department, low-back-pain, muscle-relaxants, nih
Organization: U.S. Department of Health & Human Services
State and Substate Estimates of Nonmedical Use of Prescription Pain Relievers

This report provides state and substate estimates of nonmedical use of prescription pain relievers among people aged 12 or older using combined 2012-2014 National Survey on Drug Use and Health data. Estimates are provided for the nation as a whole and for each state and substate areas. Comparisons are made to estimates from 2010–2012.

Tags: nonmedical-use, nsduh-data, prescription-pain-relievers, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Fibroblasts and monocyte macrophages contract and degrade three-dimensional collagen gels in extended co-culture

Background
          Inflammatory cells are believed to play a prominent role during tissue repair and remodeling. Since repair processes develop and mature over extended time frames, the present study was designed to evaluate the effect of monocytes and fibroblasts in prolonged culture in three-dimensional collagen gels.
        
        
          Methods
          Blood monocytes from healthy donors and human fetal lung fibroblasts were cast into type I collagen gels and maintained in floating cultures for three weeks.
        
        
          Results
          Fibroblast-mediated gel contraction was initially inhibited by the presence of monocytes (P < 0.01). However, with extended co-culture, contraction of the collagen gels was greatly augmented (P < 0.01). In addition, with extended co-culture, degradation of collagen in the gels occurred. The addition of neutrophil elastase to the medium augmented both contraction and degradation (P < 0.01). Prostaglandin E2 production was significantly increased by co-culture and its presence attenuated collagen degradation.
        
        
          Conclusion
          The current study, therefore, demonstrates that interaction between monocytes and fibroblasts can contract and degrade extracellular matrix in extended culture.

Tags: collagen-degradation, fibroblast-contraction, monocyte-macrophage, nih, tissue-remodeling
Organization: U.S. Department of Health & Human Services
Publications Using SAMHSA Data2018 Uniform Reporting System (URS) Table for Kentucky

This is the 2018 Uniform Reporting System (URS) Output Tables for Kentucky. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant, kentucky, mental-health-services, outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Physiological function of the maltose operon regulator, MalR, in

Background
          Maltose metabolism is initiated by an ATP-dependent permease system in Lactococcus lactis. The subsequent degradation of intracellular maltose is performed by the concerted action of Pi-dependent maltose phosphorylase and β-phosphoglucomutase. In some Gram-positive bacteria, maltose metabolism is regulated by a maltose operon regulator (MalR), belonging to the LacI-GalR family of transcriptional regulators. A gene presumed to encode MalR has been found directly downstream the maltose phosphorylase-encoding gene, malP in L. lactis. The purpose of this study was to investigate the physiological role of the MalR protein in maltose metabolism in L. lactis.
        
        
          Results
          A L. lactis ssp. lactis mutant, TMB5004, deficient in the putative MalR protein, was physiologically characterised. The mutant was not able to ferment maltose, while its capability to grow on glucose as well as trehalose was not affected. The activity of maltose phosphorylase and β-phosphoglucomutase was not affected in the mutant. However, the specific maltose uptake rate in the wild type was, at its lowest, five times higher than in the mutant. This difference in maltose uptake increased as the maltose concentration in the assay was increased.
        
        
          Conclusion
          According to amino acid sequence similarities, the presumed MalR is a member of the LacI-GalR family of transcriptional regulators. Due to the suggested activating effect on maltose transport and absence of effect on the activities of maltose phosphorylase and β-phosphoglucomutase, MalR of L. lactis is considered rather as an activator than a repressor.

Tags: gene-regulation, lactococcus-lactis, malr-protein, maltose-metabolism, nih
Organization: U.S. Department of Health & Human Services
Compound 525673: p-Bromobenzylidene-pentyl-amine

Chemical compound data from PubChem database. IUPAC Name: 1-(4-bromophenyl)-N-pentylmethanimine. Molecular Formula: C12H16BrN. Molecular Weight: 254.17. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services