AndreaBozzo/ceres-open-data-index huggingface dataset:
Patent AT-E401410-T1: [Translated] COMPOSITIONS AND METHODS FOR GENETIC MODIFICATION OF PLANTS

The invention provides DNA construct comprising in the 5' to 3' direction of transcription a promotor functional in a plant, an intron, a nucleotide sequence of interest, and a terminator region, said DNA construct comprising two non-identical recombination sites, where one of said non-identical recombination site is contained within said intron.

Tags: chemistry, innovation, patent, pubchem, research
Organization: U.S. Department of Health & Human Services
Public Service Loan Forgiveness Messaging Toolkit

Many of your staff, grant recipients and partners may be eligible for loan forgiveness.  Typically, to quality you must be employed by a U.S. federal, state, local, or tribal government, a 501(c)3 non-profit or a non-profit organization that provides a qualifying service (including military service).

You can tailor these resources to spread the word about the PSLF program.  Please consider sharing in your newsletters, social media feeds or at grant recipient convenings and conferences!

Subject:  Changes to Public Service Loan Forgiveness (PSLF) Program Offer More Options for Loan Forgiveness

[INSERT STATE] Employees May Now Be Eligible

The COVID-19 pandemic resulted in financial hardship for many, including members of the human services workforce. As a [INSERT STATE] employee, you may now be eligible for federal student loan forgiveness for your important public service, even if you were not eligible before.

ACF has created a PSLF landing page that includes resources for you to share.  It includes the March 31 webinar
  
  

 hosted by the Office of Early Childhood Development, in partnership with the Department of Education, attended by over 17,000 early educators. A webinar for the broader human services community was held on May 26th.  Both recordings, as well as PDFs and Frequently Asked Questions, are housed on the site. Please help us share this news with the broader human services workforce, including all of you who work here at [INSERT STATE].

The Department of Education issued a waiver that allows you to get credit for past payments even if you didn’t make the payment on time, didn’t pay the full amount due, or weren’t on a the right repayment plan. Until Oct. 31, 2022, federal student loan borrowers can get credit for payments that previously didn’t qualify for Public Service Loan Forgiveness (PSLF). Many people in the human services sector (including those that work in government and nonprofits) qualify for this program but don’t know about it. See if you qualify
  
  

.

Because of the COVID-19 emergency, the U.S. Department of Education announced a change to Public Service Loan Forgiveness (PSLF) program rules. For a limited time, borrowers may receive credit for past periods of repayment that would otherwise not qualify for loan forgiveness. The waiver expires October 31, 2022. See if you qualify and apply today
  
  

!

Did you know that for a limited time, borrowers may receive credit for past periods of repayment that would otherwise not qualify for the Public Service Loan Forgiveness program? Read the FAQs to learn more and see if you qualify.

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Metadata-only record linking to the original dataset. Open original dataset below.

Tags: fiscal, grant, policy, public, scope
Organization: U.S. Department of Health & Human Services
Compound 526760: Prop-2-enyl 2-pentoxyacetate

Chemical compound data from PubChem database. IUPAC Name: prop-2-enyl 2-pentoxyacetate. Molecular Formula: C10H18O3. Molecular Weight: 186.25. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Fluorescence of fungi in superficial and deep fungal infections

Background
          Fluorescence of many fungi is noted when H&E stained sections are examined under a fluorescent microscope. In theory, this phenomenon could aid in the diagnosis of cutaneous and disseminated fungal infections without the delay associated with special stains. Seventy-six cases of superficial and deep fungal infections and 3 cases of protothecosis were studied to determine the clinical usefulness of this technique.
        
        
          Results
          In most cases, fluorescence was noted, but was not intense. Fluorescence of fungi did not correlate with the age of the specimen. In most cases, organisms in H&E stained sections were more easily identified with routine light microscopy than with fluorescent microscopy.
        
        
          Conclusion
          This report suggests that in H&E stained skin specimens, fluorescent microscopy is of little benefit in the identification of fungal organisms.

Tags: fluorescence-microscopy, fungal-infections, histopathology, nih, skin-specimens
Organization: U.S. Department of Health & Human Services
4.16a Facility licensing, certification, or accreditation, by type of care offered: 2011. Number

This is a National Survey of Substance Abuse Treatment Services (N-SSATS) data table showing facility licensing, certification, or accreditation, by type of care offeredfacility in 2011. N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 States, the District of Columbia, and other U.S. jurisdictions.

Tags: behavioral-health, facility-licensing, n-ssats, samhsa, substance-abuse-treatment
Organization: U.S. Department of Health & Human Services
Patent AT-E401298-T1: [Translated] IMPROVED METHOD FOR PRODUCING 2S,3S- N-ISOBUTYL-N-(2-HYDROXY-3-AMINO-4-PHENYLBUTYL)- - NITROBENZENESULFONYLAMIDE HYDROCHLORIDE AND OTHER DERIVATIVES OF 2-HYDROXY-1,3-DIAMINE

The present invention provides a new process for the preparation of 2S,3S-N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonyl amide hydrochloride, wherein this compound is prepared directly from the chloromethyl alcohol. Importantly, the process of the present invention results in higher yields of 2S,3S-N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide hydrochloride without sacrificing its purity. The processes of the present invention can be used to prepare not only the 2S,3S-derivative, but also the 2R,3S-, 2S,2R- and the 2R,3R-derivatives.

Tags: chemistry, innovation, patent, pubchem, research
Organization: U.S. Department of Health & Human Services
Training activities and costs to be funded through titles IV-B and IV-E

Title IV-B and IV-E Funded Training Activities and Costs:
  
  

 This webpage provides the text of the Social Security Act regarding how training activities and costs are funded through Title IV-B and IV-E.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: child, funding, policy, social, welfare
Organization: U.S. Department of Health & Human Services
Itt1p, a novel protein inhibiting translation termination in

Background
          Termination of translation in eukaryotes is controlled by two interacting polypeptide chain release factors, eRFl and eRF3. eRFl recognizes nonsense codons UAA, UAG and UGA, while eRF3 stimulates polypeptide release from the ribosome in a GTP- and eRFl – dependent manner. Recent studies has shown that proteins interacting with these release factors can modulate the efficiency of nonsense codon readthrough.
        
        
          Results
          We have isolated a nonessential yeast gene, which causes suppression of nonsense mutations, being in a multicopy state. This gene encodes a protein designated Itt1p, possessing a zinc finger domain characteristic of the TRIAD proteins of higher eukaryotes. Overexpression of Itt1p decreases the efficiency of translation termination, resulting in the readthrough of all three types of nonsense codons. Itt1p interacts in vitro with both eRFl and eRF3. Overexpression of eRFl, but not of eRF3, abolishes the nonsense suppressor effect of overexpressed Itt1p.
        
        
          Conclusions
          The data obtained demonstrate that Itt1p can modulate the efficiency of translation termination in yeast. This protein possesses a zinc finger domain characteristic of the TRIAD proteins of higher eukaryotes, and this is a first observation of such protein being involved in translation.

Tags: gene-expression, nih, nonsense-mutation, protein-interaction, translation-termination
Organization: U.S. Department of Health & Human Services
Patent AT-E399771-T1: [Translated] METHOD FOR PRODUCING 1,2-EPOXY-3-CHLOROPROPANE

Production of epichlorohydrin (1,2-epoxy-3-chloropropane) by reacting allyl chloride with hydrogen peroxide in the presence of a catalyst and optionally a solvent comprises maintaining the pH between 1.5 and less than 4.8.

Tags: chemistry, innovation, patent, pubchem, research
Organization: U.S. Department of Health & Human Services
Respirable antisense oligonucleotides: a new drug class for respiratory disease

Respirable antisense oligonucleotides (RASONs), which attenuate specific disease-associated mRNAs, represent a new class of respiratory therapeutics with considerable potential. RASONs overcome previous obstacles that have impeded the development of antisense therapeutics targeting diseases in other organ systems. RASONs are delivered directly to the target tissue via inhalation; their uptake seems to be enhanced by cationic properties inherent in pulmonary surfactant, and, because of the markedly different target properties of mRNA and proteins, they can have very long durations of effect compared with traditional drugs targeting the protein of the same gene. RASONs contain chemical modifications that decrease their degradation by cellular nucleases. However, total insensitivity to nucleases is probably not an optimal design criterion for RASONs, because moderate nuclease sensitivity can prevent their systemic delivery, decreasing the potential for systemic toxicity. EPI-2010 is a 21-mer phosphorothioate RASON that attenuates bronchoconstriction, inflammation and surfactant depletion in preclinical models of human asthma, has a duration of effect of seven days, and seems to undergo minimal systemic delivery.

Tags: antisense-oligonucleotides, inhaled-therapeutics, nih, rasons, respiratory-disease
Organization: U.S. Department of Health & Human Services
Identification of sites phosphorylated by the vaccinia virus B1R kinase in viral protein H5R

Background
          Vaccinia virus gene B1R encodes a serine/threonine protein kinase. In vitro this protein kinase phosphorylates ribosomal proteins Sa and S2 and vaccinia virus protein H5R, proteins that become phosphorylated during infection. Nothing is known about the sites phosphorylated on these proteins or the general substrate specificity of the kinase. The work described is the first to address these questions.
        
        
          Results
          Vaccinia virus protein H5R was phosphorylated by the B1R protein kinase in vitro, digested with V8 protease, and phosphopeptides separated by HPLC. The N-terminal sequence of one radioactively labelled phosphopeptide was determined and found to correspond to residues 81-87 of the protein, with Thr-84 and Thr-85 being phosphorylated. A synthetic peptide based on this region of the protein was shown to be a substrate for the B1R protein kinase, and the extent of phosphorylation was substantially decreased if either Thr residue was replaced by an Ala.
        
        
          Conclusions
          We have identified the first phosphorylation site for the vaccinia virus B1R protein kinase. This gives important information about the substrate-specificity of the enzyme, which differs from that of other known protein kinases. It remains to be seen whether the same site is phosphorylated in vivo.

Tags: kinase-activity, nih, protein-phosphorylation, vaccinia-virus, viral-proteins
Organization: U.S. Department of Health & Human Services
Patent AT-E401362-T1: [Translated] METHOD FOR SEPARATING A POLY(ARYLENE ETHER) FROM A SOLVENT

A method of separating a polymer-solvent mixture is described wherein a polymer-solvent mixture is heated prior to its introduction into an extruder comprising as upstream vent and/or a side feeder vent to allow flash evaporation of the solvent, and downstream vents for removal of remaining solvent. The one-step method is highly efficient having very high throughput rates while at the same time providing a polymer product containing low levels of residual solvent.

Tags: chemistry, innovation, patent, pubchem, research
Organization: U.S. Department of Health & Human Services
Percutaneous treatment of chronic MRSA osteomyelitis with a novel plant-derived antiseptic

Background
          Antibiotic-resistant bacteria such as methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococcus (VRE, are an increasing problem world-wide, causing intractable wound infections. Complex phytochemical extracts such as tea tree oil and eucalypt-derived formulations have been shown to have strong bactericidal activity against MRSA in vitro. Polytoxinol (PT) antimicrobial, is the trade name of a range of antimicrobial preparations in solution, ointment and cream form.
        
        
          Methods
          We report the first use of this drug, administered percutaneously, via calcium sulphate pellets (Osteoset,TM), into bone, to treat an intractable MRSA infection of the lower tibia in an adult male.
        
        
          Results and Discussion
          Over a three month period his symptoms resolved with a healing response on x-ray and with a reduced CRP.

Tags: antibiotic-resistance, mrsa-osteomyelitis, nih, percutaneous-treatment, polytoxinol-antimicrobial
Organization: U.S. Department of Health & Human Services
Lateral gene transfer and parallel evolution in the history of glutathione biosynthesis genes

Background
          Glutathione is found primarily in eukaryotes and in Gram-negative bacteria. It has been proposed that eukaryotes acquired the genes for glutathione biosynthesis from the alpha-proteobacterial progenitor of mitochondria. To evaluate this, we have used bioinformatics to analyze sequences of the biosynthetic enzymes γ-glutamylcysteine ligase and glutathione synthetase.
        
        
          Results
          γ-Glutamylcysteine ligase sequences fall into three groups: sequences primarily from gamma-proteobacteria; sequences from non-plant eukaryotes; and sequences primarily from alpha-proteobacteria and plants. Although pairwise sequence identities between groups are insignificant, conserved sequence motifs are found, suggesting that the proteins are distantly related. The data suggest numerous examples of lateral gene transfer, including a transfer from an alpha-proteobacterium to a plant. Glutathione synthetase sequences fall into two distinct groups: bacterial and eukaryotic. Proteins in both groups have a common structural fold, but the sequences are so divergent that it is uncertain whether these proteins are homologous or arose by convergent evolution.
        
        
          Conclusions
          The evolutionary history of the glutathione biosynthesis genes is more complex than anticipated. Our analysis suggests that the two genes in the pathway were acquired independently. The gene for γ-glutamylcysteine ligase most probably arose in cyanobacteria and was transferred to other bacteria, eukaryotes and at least one archaeon, although other scenarios cannot be ruled out. Because of high divergence in the sequences, the data neither support nor refute the hypothesis that the eukaryotic gene comes from a mitochondrial progenitor. After acquiring γ-glutamylcysteine ligase, eukaryotes and most bacteria apparently recruited a protein with the ATP-grasp superfamily structural fold to catalyze synthesis of glutathione from γ-glutamylcysteine and glycine. The eukaryotic glutathione synthetase did not evolve directly from the bacterial glutathione synthetase.

Tags: gamma-glutamylcysteine-ligase, glutathione-biosynthesis, glutathione-synthetase, lateral-gene-transfer, nih
Organization: U.S. Department of Health & Human Services
Compound 529962: 3,5,5-Trimethylhex-2-enal

Chemical compound data from PubChem database. IUPAC Name: 3,5,5-trimethylhex-2-enal. Molecular Formula: C9H16O. Molecular Weight: 140.22. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2011 CMHS Uniform Reporting System (URS) Output Tables for Massachusetts

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2011. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-data, massachusetts-mental-health, mental-health-services, noms-measures, samhsa
Organization: U.S. Department of Health & Human Services
An examination of the Apo-1/Fas promoter Mva I polymorphism in Japanese patients with multiple sclerosis

Background
          The Apo-1/Fas (CD95) molecule is an apoptosis-signaling cell surface receptor belonging to the tumor necrosis factor (TNF) receptor family. Both Fas and Fas ligand (FasL) are expressed in activated mature T cells, and prolonged cell activation induces susceptibility to Fas-mediated apoptosis. The Apo-1/Fas gene is located in a chromosomal region that shows linkage in multiple sclerosis (MS) genome screens, and studies indicate that there is aberrant expression of the Apo-1/Fas molecule in MS.
        
        
          Methods
          Mva I polymorphism on the Apo-1/Fas promoter gene was detected by PCR-RFLP from the DNA of 114 Japanese patients with conventional MS and 121 healthy controls. We investigated the association of the Mva I polymorphism in Japanese MS patients using a case-control association study design.
        
        
          Results
          We found no evidence that the polymorphism contributes to susceptibility to MS. Furthermore, there was no association between Apo-1/Fas gene polymorphisms and clinical course (relapsing-remitting course or secondary-progressive course). No significant association was observed between Apo-1/Fas gene polymorphisms and the age at disease onset.
        
        
          Conclusions
          Overall, our findings suggest that Apo-1/Fas promoter gene polymorphisms are not conclusively related to susceptibility to MS or the clinical characteristics of Japanese patients with MS.

Tags: apo-1fas-gene, genetic-polymorphism, japanese-patients, multiple-sclerosis, nih
Organization: U.S. Department of Health & Human Services
Compound 525180: Pentapropylene glydol, diacetate

Chemical compound data from PubChem database. IUPAC Name: 2-[2-[2-[2-(2-acetyloxypropoxy)propoxy]propoxy]propoxy]propyl acetate. Molecular Formula: C19H36O8. Molecular Weight: 392.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Patent AT-E400658-T1: [Translated] ENTERIC TRANSMITTED NON-A/NON-B HEPATITIS VIRUS AGENT AND CHARACTERISTIC EPITOPES OF THE SAME

Viral proteins derived from an enterically transmitted non-A/non-B viral hepatitis agent (HEV) are disclosed. In one embodiment, the protein is immunologically reactive with antibodies present in individuals infected with the viral hepatitis agent. This protein is useful in a diagnostic method for detecting infection by the enterically transmitted agent. Specific epitopes have been identified that are reactive with sera of individual infected with different strains of HEV. Also disclosed are DNA probes derived from a cloned sequence of the viral agent. These probes are useful for identifying and sequencing the entire viral agent and for assaying the presence of the viral agent in an infected sample, by using probe-specific amplification of virus-derived DNA fragments.

Tags: chemistry, innovation, patent, pubchem, research
Organization: U.S. Department of Health & Human Services
Compound 526511: 2-Isothiocyanato-4-methylpentanoic acid ethyl ester

Chemical compound data from PubChem database. IUPAC Name: ethyl 2-isothiocyanato-4-methylpentanoate. Molecular Formula: C9H15NO2S. Molecular Weight: 201.29. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Florida (FL)

This report presents estimates for measures of substance use and mental health based on the combined 2010 and 2011 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for Florida for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: florida-health, mental-health, nsduh-data, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Obstructive sleep apnea and vascular disease

There is emerging evidence linking obstructive sleep apnea (OSA) to vascular disease, including hypertension. This relationship may be independent of co-morbidity, such as obesity. Even apparently healthy OSA patients have evidence of subtle functional vascular abnormalities that are known to occur in patients with hypertension and atherosclerosis. Untreated OSA may possibly contribute to the initiation and/or progression of pathophysiologic mechanisms involved in hypertension, heart failure, cardiac ischemia and stroke. This brief commentary will examine the evidence and mechanisms linking OSA to vascular disease.

Tags: cardiovascular-disease, hypertension, nih, obstructive-sleep-apnea, vascular-disease
Organization: U.S. Department of Health & Human Services
Patent AT-E401381-T1: [Translated] LIQUID CRYSTALLINE INTERPENETRATING POLYMER NETWORKS

A photovoltaic cell is provided. The photovoltaic cell can be an interconnecting liquid crystalline polymer network. Reactive mesogens of the formula B-S-A-S-B wherein A is a chromophore, S is a spacer and B is an end group susceptible to polymerization are used in the manufacture of the interconnecting liquid crystalline polymer network.

Tags: chemistry, innovation, patent, pubchem, research
Organization: U.S. Department of Health & Human Services
Compound 527402: 5-Ethylindene

Chemical compound data from PubChem database. IUPAC Name: 5-ethyl-1H-indene. Molecular Formula: C11H12. Molecular Weight: 144.21. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services