AndreaBozzo/ceres-open-data-index huggingface dataset:
Calcium dynamics during fertilization in

Background
          Of the animals typically used to study fertilization-induced calcium dynamics, none is as accessible to genetics and molecular biology as the model organism Caenorhabditis elegans. Motivated by the experimental possibilities inherent in using such a well-established model organism, we have characterized fertilization-induced calcium dynamics in C. elegans.
        
        
          Results
          Owing to the transparency of the nematode, we have been able to study the calcium signal in C. elegans fertilization in vivo by monitoring the fluorescence of calcium indicator dyes that we introduce into the cytosol of oocytes. In C. elegans, fertilization induces a single calcium transient that is initiated soon after oocyte entry into the spermatheca, the compartment that contains sperm. Therefore, it is likely that the calcium transient is initiated by contact with sperm. This calcium elevation spreads throughout the oocyte, and decays monotonically after which the cytosolic calcium concentration returns to that preceding fertilization. Only this single calcium transient is observed.
        
        
          Conclusion
          Development of a technique to study fertilization induced calcium transients opens several experimental possibilities, e.g., identification of the signaling events intervening sperm binding and calcium elevation, identifying the possible roles of the calcium elevation such as the completion of meiosis, the formation of the eggshell, and the establishing of the embryo's axis of symmetry.

Tags: c-elegans, calcium-dynamics, fertilization, nih, oocytes
Organization: U.S. Department of Health & Human Services
Weather conditions and Bell's palsy: five-year study and review of the literature

Background
          Climatic or meteorological condition changes have been implicated in the pathogenesis of Bell's palsy (BP). We evaluate the influence of meteorological parameters, such as temperature, humidity, and atmospheric pressure, and their variation and covariation on the incidence of BP and present a review of the literature on the effect of meteorological conditions on facial nerve function.
        
        
          Methods
          A total of 171 cases of BP admitted to our Department over a five-year period were studied. The meteorological database included daily values of 13 distinct parameters recorded at the meteorological station of the University of Ioannina during this period. A relationship between each meteorological variable and the incidence of BP was investigated by applying (Χ2) test on data from 13 contingency tables. In addition, the influence of different weather types on the incidence of BP was also investigated. For this purpose Cluster Analysis was used to create eight clusters (weather types) for the Ioannina prefecture and (Χ2) test was applied on the contingency tables consisting of the days of BP cases for each cluster.
        
        
          Results
          No significant correlation was found either between BP and each distinct meteorological parameter or between BP and any specific weather.
        
        
          Conclusions
          Meteorological conditions, such as those dominating in the Northwestern Greece, and/or their changes have little effect on the incidence of BP. Multicenter studies taking into account atmospheric pollution, and climatic differences between countries, are necessary to scrutinize the environmental effects on facial nerve function.

Tags: bells-palsy, facial-paralysis, meteorological-factors, nih, weather-conditions
Organization: U.S. Department of Health & Human Services
Body mass indices in patients with disabling hip osteoarthritis

Hip osteoarthritis (OA) is a degenerative joint disease that results in substantial morbidity. The disease may be preventable in some instances by reducing risk factors associated with the disease. We undertook a study to determine whether being overweight or obese, a health risk that applies to younger and older age groups, is commonly associated with hip joint OA. The body mass indices (BMIs) of 1021 males and females ranging in age from 23 to 94 years and requiring surgery for end-stage hip joint OA were analyzed to find the prevalence of high body weights at the time of surgery. Being overweight was defined as having a BMI of 25–29.9 kg/m2 and being obese as having a BMI >30 kg/m2. BMIs indicative of overweight were recorded for 68% of the patients surveyed. Of 35 patients aged 30–39 years, 53.3% had BMIs >25, with a mean of 28.8, which nearly reaches the lower limit defined for obesity. On average, patients who had had previous surgery and complications warranting reimplantation of new surgical devices had BMIs in the obese range. Our findings suggest that a high percentage of patients with end-stage hip OA are overweight, including younger adults and those with symptoms of 3–6 months' duration. Moreover, patients whose BMIs are in the obese range may be at increased risk for removal and reimplantation of their prosthesis.

Tags: body-mass-index, hip-osteoarthritis, joint-replacement, nih, osteoarthritis-surgery
Organization: U.S. Department of Health & Human Services
The SACWIS Assessment Review Report (SARR) Action Plan Development and Tracking

This webinar, sponsored by the Children's Bureau's Division of State Systems (DSS) builds on guidance set forth in Statewide Automated Child Welfare Information Systems (SACWIS) Technical Bulletin #1: Action Plan Guidance and Examples issued in December, 2005. This webinar provided direction on how to construct an action plan, identified common pitfalls and benefits of action plans and described the tracking process for action plans. The webinar included time for Q&A and audience discussion. Speakers included Joe Castro, consultant to the Children's Bureau, Pete Howe, Division of State Systems, Children's Bureau and Dian Carroll, Division of State Systems, Children's Bureau.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: assessment, child, guidance, instruction, policy
Organization: U.S. Department of Health & Human Services
Compound 525188: Tripropylene glycol, diacetate

Chemical compound data from PubChem database. IUPAC Name: 2-[2-(2-acetyloxypropoxy)propoxy]propyl acetate. Molecular Formula: C13H24O6. Molecular Weight: 276.33. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Oregon, 2015

This is a behavioral health report for the state of Oregon. The report utilizes data from the National Survey on Drug Use and Health (NSDUH), and the Uniform Reporting System. The topics addressed in the report include youth substance use, youth mental health and treatment, mental health and treatment, substance use and substance use treatment.

Tags: adult-substance-use, mental-health-treatment, oregon-behavioral-health, samhsa, youth-substance-use
Organization: U.S. Department of Health & Human Services
The NSDUH Report: Accessing National and State Data from the National Survey on Drug Use and Health

This short report summarizes the type of national-, State-, and substate-level publications and methodologies using National Survey on Drug Use and Health (NSDUH). Information on accessing the NSDUH public-use file (PUF), the restricted-use data analysis system (R-DAS), and other future NSDUH data access options are discussed.

Tags: data-access, mental-health, samhsa, substance-use, survey-data
Organization: U.S. Department of Health & Human Services
Compound 525631: N,N-Dimethyl-N'-hexyl-p-chlorobenzamidine

Chemical compound data from PubChem database. IUPAC Name: 4-chloro-N'-hexyl-N,N-dimethylbenzenecarboximidamide. Molecular Formula: C15H23ClN2. Molecular Weight: 266.81. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 528359: 1,2,4,6-Tetrathiepane, 3,5,7-trimethyl-

Chemical compound data from PubChem database. IUPAC Name: 3,5,7-trimethyl-1,2,4,6-tetrathiepane. Molecular Formula: C6H12S4. Molecular Weight: 212.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
NSDUH 2022 Sample Experience Report

This report is a follow-up to the 2022 National Survey on Drug Use and Health (NSDUH)Sample Design Report. It further documents the 2022 NSDUH sample experiences by comparing expected outcomes with what actually occurred, and documenting unexpected issues that came up during the year. A summary of the sample design is included for context.Chapters:Introduces the report and summarizes the impact of the coronavirus 2019 (COVID-19) pandemic on sample design and data collection.Revisits the 2022 sample design.Documents the sample experiences at the segment levelDocuments the sample experiences at the dwelling-unit levelDocuments the sample experiences at the person levelLooks at sampling error, through a computation of design effects and a comparison of observed and expected precision

Tags: covid-19-impact, nsduh-sample-design, samhsa, sampling-error, substance-use-survey
Organization: U.S. Department of Health & Human Services
Denver: Drug-Related Emergency Department Visits, 2004-2011 - Suicide Attempts

Excel file with estimates, rates, relative standard errors, trends and confidence intervals for all drug-related emergency department (ED) visits involving suicide attempts in the Denver metropolitan area, covering 2004-2011.  Drug-related suicide attempts include visits for drug overdoses and for suicide attempts by other means (e.g., using a firearm) if drugs were involved or related to the suicide attempt.

Tags: denver-metro-area, drug-related-suicide, ed-visits, samhsa, suicide-attempts
Organization: U.S. Department of Health & Human Services
Publications Using SAMHSA DataBehavioral Health Barometer: Louisiana, 2014

This is a behavioral health report for the state of Louisiana. It uses the National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment Services (NSSATS) to address the topics of youth substance use, youth mental health and treatment, adult mental health and treatment, substance use, and substance use treatment for the years 2009 to 2013.

Tags: louisiana-behavioral-health, mental-health-louisiana, samhsa, substance-use-louisiana, youth-behavioral-health
Organization: U.S. Department of Health & Human Services
Quantitative assessment of the use of modified nucleoside triphosphates in expression profiling: differential effects on signal intensities and impacts on expression ratios

Background
          The power of DNA microarrays derives from their ability to monitor the expression levels of many genes in parallel. One of the limitations of such powerful analytical tools is the inability to detect certain transcripts in the target sample because of artifacts caused by background noise or poor hybridization kinetics. The use of base-modified analogs of nucleoside triphosphates has been shown to increase complementary duplex stability in other applications, and here we attempted to enhance microarray hybridization signal across a wide range of sequences and expression levels by incorporating these nucleotides into labeled cRNA targets.
        
        
          Results
          RNA samples containing 2-aminoadenosine showed increases in signal intensity for a majority of the sequences. These results were similar, and additive, to those seen with an increase in the hybridization time. In contrast, 5-methyluridine and 5-methylcytidine decreased signal intensities. Hybridization specificity, as assessed by mismatch controls, was dependent on both target sequence and extent of substitution with the modified nucleotide. Concurrent incorporation of modified and unmodified ATP in a 1:1 ratio resulted in significantly greater numbers of above-threshold ratio calls across tissues, while preserving ratio integrity and reproducibility.
        
        
          Conclusions
          Incorporation of 2-aminoadenosine triphosphate into cRNA targets is a promising method for increasing signal detection in microarrays. Furthermore, this approach can be optimized to minimize impact on yield of amplified material and to increase the number of expression changes that can be detected.

Tags: dna-microarrays, gene-expression, nih, nucleoside-triphosphates, rna-hybridization
Organization: U.S. Department of Health & Human Services
The NSDUH Report: State Estimates of Nonmedical Use of Prescription Pain Relievers

This short report uses 2010 to 2011 National Survey on Drug Use and Health (NSDUH) to assess past year nonmedical use of prescription-type drugs among persons aged 12 or older by State. Results are shown by age group and State by age group for 2009-2012 and 2010-2011.

Tags: nonmedical-use, pain-relievers, prescription-drugs, samhsa, state-estimates
Organization: U.S. Department of Health & Human Services
Trend Tables (Standard Errors and P Values) - 7.1 to 7.45

These detailed tables show standard errors for trends in totals and prevalence estimates of illicit drug use, risk and protective factors, substance initiation, substance dependence/abuse, and need/receipt of substance use treatment from the 2010 National Survey on Drug Use and Health (NSDUH). Substances examined include illicit drugs (e.g., marijuana, cocaine, heroin, hallucinogens (including LSD, PCP, Ecstasy, Ketamine, DMT/AMT/Foxy, Salvia divinorum), inhalants, and the nonmedical use of prescription-type pain relievers (including OxyContin), tranquilizers, stimulants (Adderall), sedatives (GHB, Ambien), non-prescription cold medicine, alcohol, and tobacco products (including cigarettes, smokeless tobacco, cigars, pipes). Standard errors are provided for totals and estimates of lifetime, past year, and past month use by age group, gender, race/ethnicity, education level, employment status, and geographic area.

Tags: drug-trends, nsduh-data, samhsa, standard-errors, substance-use
Organization: U.S. Department of Health & Human Services
Minneapolis: Drug-Related Emergency Department Visits, 2004-2011 - Seeking Detox

Excel file with estimates, rates, relative standard errors, trends and confidence intervals for all drug-related emergency department (ED) visits involving patients seeking detox in the Minneapolis metropolitan area, covering 2004-2011. This includes nonemergency requests made through the ED for admission to detoxification unit, visits to obtain medical clearance before being incarcerated, and acute emergencies where an individual is experiencing withdrawal symptoms and requests detox. These estimates do not include patients who seek or enter the hospital\'s detox unit through other avenues.

Tags: detoxification-seeking, drug-related-ed, minneapolis, samhsa, substance-abuse-trends
Organization: U.S. Department of Health & Human Services
Table 19. Illicit Drug Dependence or Abuse in the Past Year among Persons Aged 12 or Older, by State and Substate Regions: Percentages, Annual Averages Based on 2010, 2011, and 2012 NSDUHs

Table 19. Illicit Drug Dependence or Abuse in the Past Year among Persons Aged 12 or Older, by State and Substate Regions: Percentages, Annual Averages Based on 2010, 2011, and 2012 NSDUHs

Tags: adolescent-drug-use, illicit-drug-abuse, nsduh-data, samhsa, substance-use-disorder
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: HHS Region I, 2014

This is a behavioral health report for HHS Region I of the United States and utilizes data from the National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment (N-SSATS), collected annually. The topics addressed in the reports include youth substance use, youth mental health and treatment, adult mental health, substance use and substance use treatment.

Tags: behavioral-health, hhs-region-i, mental-health, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Molecular cloning of the rat proteinase-activated receptor 4 (PAR4)

Background
          The proteinase-activated receptor 4 (PAR4) is a G-protein-coupled receptor activated by proteases such as thrombin and trypsin. Although activation of PAR4 has been shown to modulate rat gastrointestinal motility, the rat PAR4 sequence was unknown until now. This study aimed to identify the rat PAR4 cDNA.
        
        
          Results
          The cDNA coding for the rat PAR4 homologue was cloned from the duodenum. Northern blots demonstrated a 3.0 kb transcript in the duodenum. Protein homology with mouse and human counterparts was 90% and 75% respectively. PAR4 is expressed predominantly in the esophagus, stomach, duodenum and the spleen. When expressed in COS cells, PAR4 is activated by trypsin (1 nM), thrombin (50 nM), mouse PAR4 specific peptide (500 μM) and a putative rat PAR4 specific activating peptide (100 μM), as measured by intracellular Ca2+-changes.
        
        
          Conclusions
          We have identified and characterized cDNA encoding the rat PAR4 homologue. PAR4 is expressed predominantly in the upper gastrointestinal tract. It is activated by trypsin, thrombin and its newly identified rat PAR4 specific activating peptide.

Tags: gastrointestinal-motility, nih, par4-receptor, proteinase-activated-receptor, thrombin-receptor
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Connecticut, 2013

This is a behavioral health report for the state of Conneticut. It uses the  National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment Services (NSSATS) to address the topics of youth substance use , youth mental health and treatment, adult mental health and treatment, substance use, substance use treatment for the years 2008 to 2012.

Tags: adult-mental-health, connecticut-behavioral-health, samhsa, substance-abuse-treatment, youth-substance-use
Organization: U.S. Department of Health & Human Services
Decision-making in Child Protective Services: A Study of Effectiveness, Phase I, 1997

The study will examine the criteria used by CPS workers to determine the level of the risk/severity for different types of abuse, to assess the likelihood of recurrence, and to decide to substantiate.  Criteria associated with placement during the investigation phase and postsubstantiation decisions regarding risk of imminent harm also will be examined.  Researchers will identify criteria most closely associated with each decision point and will develop models for each type of decision under study. These predictive models then can serve as a foundation for the development of decision protocols and recommendations regarding the enhancement of operation procedures.

Investigators: English, Diana

Tags: abuse, care, ndacan, policy, reporting
Organization: U.S. Department of Health & Human Services
Serovar distribution of a DNA sequence involved in the antigenic relationship between

Background
          Horses infected with Leptospira present several clinical disorders, one of them being recurrent uveitis. A common endpoint of equine recurrent uveitis is blindness. Serovar pomona has often been incriminated, although others have also been reported. An antigenic relationship between this bacterium and equine cornea has been described in previous studies. A leptospiral DNA fragment that encodes cross-reacting epitopes was previously cloned and expressed in Escherichia coli.
        
        
          Results
          A region of that DNA fragment was subcloned and sequenced. Samples of leptospiral DNA from several sources were analysed by PCR with two primer pairs designed to amplify that region. Reference strains from serovars canicola, icterohaemorrhagiae, pomona, pyrogenes, wolffi, bataviae, sentot, hebdomadis and hardjo rendered products of the expected sizes with both pairs of primers. The specific DNA region was also amplified from isolates from Argentina belonging to serogroups Canicola and Pomona. Both L. biflexa serovar patoc and L. borgpetersenii serovar tarassovi rendered a negative result.
        
        
          Conclusions
          The DNA sequence related to the antigen mimicry with equine cornea was not exclusively found in serovar pomona as it was also detected in several strains of Leptospira belonging to different serovars. The results obtained with L. biflexa serovar patoc strain Patoc I and L. borgpetersenii serovar tarassovi strain Perepelicin suggest that this sequence is not present in these strains, which belong to different genomospecies than those which gave positive results. This is an interesting finding since L. biflexa comprises nonpathogenic strains and serovar tarassovi has not been associated clinically with equine uveitis.

Tags: antigenic-relationship, dna-sequencing, equine-uveitis, leptospira-serovars, nih
Organization: U.S. Department of Health & Human Services
2023 Uniform Reporting System (URS) Table For Kentucky

This is the 2023 Uniform Reporting System (URS) Output Tables for Kentucky. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: kentucky, mental-health-services, national-outcome-measures, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
NSDUH 2019 Questionnaire

Browse the English interview questionnaire for the 2019 National Survey on Drug Use and Health (NSDUH). The document provides the exact questions given to respondents in their full context, along with the skip patterns that determined whether a person was asked a question or not. There is also information on which sections were interviewer administered, and a section that summarizes changes made to the questionnaire for 2019.

Tags: behavioral-health-survey, mental-health, nsduh-questionnaire, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Treatment Episode Data Set (TEDS) 2007 Discharges from Substance Abuse Treatment Services

This report presents results from the Treatment Episode Data Set (TEDS) for clients discharged from substance abuse treatment in 2007. The report provides information on treatment completion, length of stay in treatment, and demographic and substance abuse characteristics of people discharged from alcohol or drug treatment in facilities that reported to individual state administrative data systems.

Tags: alcohol-drug-treatment, samhsa, substance-abuse-treatment, teds-discharges, treatment-outcomes
Organization: U.S. Department of Health & Human Services