AndreaBozzo/ceres-open-data-index huggingface dataset:
Effects of chronic inflammatory bowel diseases on left ventricular structure and function: a study protocol

Background
          Experimental evidences suggest an increased collagen deposition in inflammatory bowel diseases (IBD). In particular, large amounts of collagen type I, III and V have been described and correlated to the development of intestinal fibrotic lesions. No information has been available until now  about the possible increased collagen deposition far from the main target organ. In the hypothesis that chronic inflammation and increased collagen metabolism are reflected also in the systemic circulation, we aimed this study to evaluate the effects on left ventricular wall structure by assessing splancnic and systemic collagen metabolism (procollagen III assay), deposition (ultrasonic tissue characterization), and cardiac function (echocardiography) in patients with different long standing history of IBD, before and after surgery.
        
        
          Methods
          Thirty patients affected by active IBD, 15 with Crohn and 15 with Ulcerative Colitis, submitted to surgery will be enrolled in the study in a double blind fashion. They will be studied before the surgical operation and 6, 12 months after surgery. A control group of 15 healthy age and gender-matched subjects will also be studied. At each interval blood samples will be collected in order to assess the collagen metabolism; a transthoracic echocardiogram will be recorded for the subsequent determination of cardiac function and collagen deposition.
        
        
          Discussion
          From this study protocol we expect additional information about the association between IBD and cardiovascular disorders; in particular to address the question if chronic inflammation, through the altered collagen metabolism, could affect left ventricular structure and function in a manner directly related to the estimated duration of the disease.

Tags: collagen-deposition, crohn-disease, inflammatory-bowel-disease, left-ventricular-function, nih
Organization: U.S. Department of Health & Human Services
Early inflammatory markers in elicitation of allergic contact dermatitis

Background
          Allergic Contact Dermatitis (ACD) is regarded as a T-cell-mediated delayed-type hypersensitivity reaction. We studied the kinetics of the expression of CS-1 fibronectin, thymus and activation-regulated chemokine (CCL17/ TARC) and different chemokine receptors (CR) in skin biopsies from individuals suffering from back problems, with the antigen responsible of their contact dermatitis and an irrelevant antigen.
        
        
          Methods
          Samples were taken at 2, 10, and 48 hours for histological and immunohistochemical studies using monoclonal antibodies against human CS-1 fibronectin, CCL17, CD3, CD68, CD49d, CXCR3, CCR5, and CCR3.
        
        
          Results
          At positive antigen stimulated sites there was an early expression of CS-1 fibronectin (2 hours), followed by CCL17 and a later accumulation of alplha4/beta1+ (CD49d), CD3+, CD68+, CXCR3+ and CCR5+ mononuclear cells. At 48 hours, approximately 59 % of infiltrating cells were CXCR3+, 42% CCR5+, and only 14 % CCR3+.
        
        
          Conclusions
          These results showed for the first time a very early expression of CS-1 fibronectin which preceded production of CCL17 in blood endothelial cells (BCEs) from patients' skin with ACD. The role of these molecules in recruitment of monocytes and effector T cells in ACD is discussed.

Tags: allergic-contact-dermatitis, ccl17-chemokine, cs-1-fibronectin, immunohistochemistry, nih
Organization: U.S. Department of Health & Human Services
San Francisco – SF Div: Drug-Related Emergency Department Visits, 2004-2011 - Accidental Ingestions

Excel file with estimates, rates, relative standard errors, trends and confidence intervals, covering 2004-2011 for emergency department visits involving accidental ingestions in the San Francisco metropolitan area (San Francisco division). This analytic category includes ED visits in which an individual accidentally or unknowingly used or was administered a prescription drug, over-the-counter medication, or dietary supplement. Drug-related accidental ingestion typically involves patients aged 5 and under.  This analytic category does not include drug misuse or abuse.File includes data for over 500 drugs, including illicit drugs, prescription and over-the-counter medications, dietary supplements, inhalants and alcohol.  Includes total visits, gender, age group, race/ethnicity, outcome of visit, drug combinations, number of drugs involved in visit, drug frequency, and drugs confirmed by toxicology.Additional detail is provided for illicit drugs, psychotherapeutic drugs, central nervous system (CNS) drugs, respiratory drugs and cardiovascular drugs.

Tags: accidental-ingestion, drug-overdose, emergency-department, pediatric-poisoning, samhsa
Organization: U.S. Department of Health & Human Services
Potential of (GATA)

Background
          The microsatellite, (GATA)n has been frequently used for DNA fingerprinting. However, very few attempts have been made to analyze (GATA)n-containing loci in rice.
        
        
          Results
          Three polymorphic (GATA)n-harboring loci viz. OS1A6, OS1H10 and OS2E7, containing 7–13 repeat motifs were identified from a genomic library of a cultivated rice, Oryza sativa var. Basmati-370 using oligonucleotide probe (GATA)4. When (GATA)n flanking primers were used to screen 26 wilds (representing different genomes of rice), 16 cultivars, 47 Indian elite rice varieties and 37 lines resistant/susceptible to bacterial blight, up to 22 alleles were obtained at an individual locus. Also, interestingly the bacterial blight resistant lines clustered into a separate group from the remaining rice genotypes, when a dendrogram was constructed based on the polymorphism obtained at the three loci. This may be due to the partial homology of the clones OS1H10 and OS2E7 to regions encoding O. longistaminata receptor kinase-like protein and pathogenesis-related protein. The ability of these O. sativa flanking primers to amplify DNA of maize, wheat, barley and oat indicates that these (GATA)n-containing loci are conserved across different cereal genera.
        
        
          Conclusions
          The large allele number obtained reveals the potential of (GATA)n-containing loci as powerful tools to detect simple sequence length polymorphism (SSLP). The (GATA)n-flanking primers were not only useful in distinguishing between closely related genotypes, but could also be used for cross-species amplification and are also conserved across different cereal genera. These loci could also cluster the bacterial blight resistant/susceptible lines into different groups based on the resistance genes present in them.

Tags: bacterial-blight-resistance, dna-fingerprinting, microsatellite-analysis, nih, rice-genotypes
Organization: U.S. Department of Health & Human Services
Table 27. Had at Least One Major Depressive Episode in the Past Year among Persons Aged 18 or Older, by State and Substate Regions: Percentages, Annual Averages Based on 2008, 2009, and 2010 NSDUHs

This table presents the 2008 to 2010 National Survey on Drug Use and Health (NSDUH) estimates of past year major depressive episode among those aged 18 or older by State and substate regions.

Tags: adult-depression, major-depressive-episode, mental-health-surveillance, nsduh-data, samhsa
Organization: U.S. Department of Health & Human Services
Treatment Episode Data Set (TEDS) 1999-2009 State Admissions to Substance Abuse Treatment Services

This report presents data from the Treatment Episode Data Set (TEDS) by census division and state for admissions in 2009, and trend data for 1999 to 2009. The report provides information on the demographic and substance abuse characteristics of people aged 12 and older admitted to treatment for abuse of alcohol and/or drugs in facilities that report to individual state administrative data systems.

Tags: alcohol-drug-abuse, samhsa, substance-abuse-treatment, teds-admissions-data, treatment-admissions
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Kentucky, 2014

This is a behavioral health report for the state of Kentucky. It uses the National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment Services (NSSATS) to address the topics of youth substance use, youth mental health and treatment, adult mental health and treatment, substance use, and substance use treatment for the years 2009 to 2013.

Tags: kentucky-behavioral-health, mental-health-kentucky, samhsa, substance-use-trends, youth-mental-health
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Virginia, 2015

This is a behavioral health report for the state of Virginia. The report utilizes data from the National Survey on Drug Use and Health (NSDUH), and the Uniform Reporting System. The topics addressed in the report include youth substance use, youth mental health and treatment, mental health and treatment, substance use and substance use treatment.

Tags: mental-health-treatment, nsduh-data, samhsa, virginia-behavioral-health, youth-substance-use
Organization: U.S. Department of Health & Human Services
Search for antisense copies of beta-globin mRNA in anemic mouse spleen

Background
          Previous studies by Volloch and coworkers have reported that during the expression of high levels of β-globin mRNA in the spleen of anemic mice, they could also detect small but significant levels of an antisense (AS) globin RNA species, which they postulated might have somehow arisen by RNA-directed RNA synthesis. For two reasons we undertook to confirm and possibly extend these studies. First, previous studies in our lab have focussed on what is an unequivocal example of host RNA-directed RNA polymerase activity on the RNA genome of human hepatitis delta virus. Second, if AS globin species do exist they could in turn form double-stranded RNA species which might induce post-transcriptional gene silencing, a phenomenon somehow provoked in eukaryotic cells by AS RNA sequences.
        
        
          Results
          We reexamined critical aspects of the previous globin studies. We used intraperitoneal injections of phenylhydrazine to induce anemia in mice, as demonstrated by the appearance and ultimate disappearance of splenomegaly. While a 30-fold increase in globin mRNA was detected in the spleen, the relative amount of putative AS RNA could be no more than 0.004%.
        
        
          Conclusions
          Contrary to earlier reports, induction of a major increase in globin transcripts in the mouse spleen was not associated with a detectable level of antisense RNA to globin mRNA.

Tags: anemic-mice, antisense-rna, beta-globin-mrna, nih, spleen-rna
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: California, 2014

This is a behavioral health report for the state of California. It uses the National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment Services (NSSATS) to address the topics of youth substance use, youth mental health and treatment, adult mental health and treatment, substance use, and substance use treatment for the years 2009 to 2013.

Tags: behavioral-health, california, mental-health, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Bone morphogenetic protein-2 (BMP-2) and transforming growth factor-β1 (TGF-β1) alter connexin 43 phosphorylation in MC3T3-E1 Cells

Background
          Bone morphogenetic proteins (BMPs) and transforming growth factor-βs (TGF-βs) are important regulators of bone repair and regeneration. BMP-2 and TGF-β1 have been shown to inhibit gap junctional intercellular communication (GJIC) in MC3T3-E1 cells. Connexin 43 (Cx43) has been shown to mediate GJIC in osteoblasts and it is the predominant gap junctional protein expressed in these murine osteoblast-like cells. We examined the expression, phosphorylation, and subcellular localization of Cx43 after treatment with BMP-2 or TGF-β1 to investigate a possible mechanism for the inhibition of GJIC.
        
        
          Results
          Northern blot analysis revealed no detectable change in the expression of Cx43 mRNA. Western blot analysis demonstrated no significant change in the expression of total Cx43 protein. However, significantly higher ratios of unphosphorylated vs. phosphorylated forms of Cx43 were detected after BMP-2 or TGF-β1 treatment. Immunofluorescence and cell protein fractionation revealed no detectable change in the localization of Cx43 between the cytosol and plasma membrane.
        
        
          Conclusions
          BMP-2 and TGF-β1 do not alter expression of Cx43 at the mRNA or protein level. BMP-2 and TGF-β1 may inhibit GJIC by decreasing the phosphorylated form of Cx43 in MC3T3-E1 cells.

Tags: bmp-2, connexin-43, mc3t3-e1-cells, nih, tgf-1
Organization: U.S. Department of Health & Human Services
Oregon: 2011-2012 NSDUH

This report presents Oregon\'s estimates for 25 measures of substance use and mental health based on the combined 2011 and 2012 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided by State and for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: mental-health, oregon-nsduh, samhsa, serious-mental-illness, substance-use
Organization: U.S. Department of Health & Human Services
2005 NSDUH Detailed Tables

These are the 2005 national-level detailed tables for NSDUH.Illicit Drug Use Tables - 1.1 to 1.132Tobacco Product and Alcohol Use Tables - 2.1 to 2.114Risk and Protective Factors Tables - 3.1 to 3.69Incidence Tables - 4.1 to 4.16Dependence, Abuse, and Treatment Tables - 5.1 to 5.82Mental Health Tables - 6.1 to 6.67Miscellaneous Tables - 7.1 to 7.133Trend Tables - 8.1 to 8.37Sample Size and Population Estimates Tables - 9.1 to 9.22

Tags: mental-health, risk-factors, samhsa, substance-use, treatment-data
Organization: U.S. Department of Health & Human Services
Table 11. Perceptions of Great Risk of Having Five or More Drinks of an Alcoholic Beverage Once or Twice a Week among Persons Aged 12 or Older, by State and Substate Regions: Percentages, Annual Averages Based on 2008, 2009, and 2010 NSDUHs

This table presents the 2008 to 2010 National Survey on Drug Use and Health (NSDUH) estimates of perceptions of great risk of having five or more drinks of alcohol among those aged 12 or older by State and substate regions.

Tags: adolescent-alcohol-use, alcohol-risk-perception, binge-drinking, samhsa, substance-use-survey
Organization: U.S. Department of Health & Human Services
2017 Uniform Reporting System (URS) Table for New Hampshire

This is the 2017 Uniform Reporting System (URS) Output Tables for New Hampshire. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, national-outcome-measures, samhsa, urs-data
Organization: U.S. Department of Health & Human Services
2012 State Profile - Utah

This is a National Survey of Substance Abuse Treatment Services (N-SSATS) annual report showing the state profile for Utah in 2012. N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 States, the District of Columbia, and other U.S. jurisdictions.

Tags: addiction-treatment-facilities, n-ssats, samhsa, substance-abuse-treatment, utah-health-services
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Vermont, 2014

This is a behavioral health report for the state of Vermont. It uses the  National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment Services (NSSATS) to address the topics of youth substance use , youth mental health and treatment, adult mental health and treatment, substance use, substance use treatment, and medicare enrollees for the years 2009 to 2013.

Tags: adult-mental-health, samhsa, substance-use-treatment, vermont-behavioral-health, youth-substance-use
Organization: U.S. Department of Health & Human Services
The NSDUH Report: Nonmedical Use of Prescription-Type Drugs, by County Type

This report uses 2005 to 2011 National Survey on Drug Use and Health (NSDUH) to assess past year and past month nonmedical use of prescription-type drugs among persons aged 12 or older for rural non-metropolitan counties, urbanized non-metropolitan counties and metropolitan counties. Results are shown by age group, gender, and prescription drug type.

Tags: county-level-data, nonmedical-drug-use, prescription-drug-abuse, samhsa, substance-use-survey
Organization: U.S. Department of Health & Human Services
2012 State Profile - California

This is a National Survey of Substance Abuse Treatment Services (N-SSATS) annual report showing the state profile for California in 2012. N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 States, the District of Columbia, and other U.S. jurisdictions.

Tags: california, n-ssats, samhsa, substance-abuse-treatment, treatment-facilities
Organization: U.S. Department of Health & Human Services
Articular cartilage and changes in Arthritis: Collagen of articular cartilage

The extracellular framework and two-thirds of the dry mass of adult articular cartilage are polymeric collagen. Type II collagen is the principal molecular component in mammals, but collagens III, VI, IX, X, XI, XII and XIV all contribute to the mature matrix. In developing cartilage, the core fibrillar network is a cross-linked copolymer of collagens II, IX and XI. The functions of collagens IX and XI in this heteropolymer are not yet fully defined but, evidently, they are critically important since mutations in COLIX and COLXI genes result in chondrodysplasia phenotypes that feature precocious osteoarthritis. Collagens XII and XIV are thought also to be bound to fibril surfaces but not covalently attached. Collagen VI polymerizes into its own type of filamentous network that has multiple adhesion domains for cells and other matrix components. Collagen X is normally restricted to the thin layer of calcified cartilage that interfaces articular cartilage with bone.

Tags: articular-cartilage, chondrodysplasia, collagen-composition, nih, osteoarthritis-research
Organization: U.S. Department of Health & Human Services
Maine: 2011-2012 NSDUH

This report presents Maine\'s estimates for 25 measures of substance use and mental health based on the combined 2011 and 2012 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided by State and for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: maine-nsduh, mental-health, samhsa, serious-mental-illness, substance-use
Organization: U.S. Department of Health & Human Services
2023 Uniform Reporting System (URS) Table For Delaware

This is the 2023 Uniform Reporting System (URS) Output Tables for Delaware. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-data, delaware-mental-health, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
United States: 2011-2012 NSDUH

This report presents the United States\'s estimates for 25 measures of substance use and mental health based on the combined 2011 and 2012 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for the United States for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: mental-health, national-survey, samhsa, substance-use, suicidal-ideation
Organization: U.S. Department of Health & Human Services
Overdistension in ventilated children

Ventilating patients with acute respiratory failure according to standardized recommendations can lead to varying volume–pressure (V-P) relationships and overdistension. Young children may be more susceptible than adults to overdistension, and individual evaluation of the effects of ventilator settings is therefore required. Three studies have applied indices for the detection of overdistension to dynamic V-P curves in ventilated children. Two of those studies compared these indices to those obtained using a reference technique ([quasi]-static V-P curves), and suggested that the c coefficient of a second order polynomial equation (SOPE) and the ratio of the volume-dependent elastance to total dynamic elastance (%E2) were suitable indices for estimating overdistension.

Tags: acute-respiratory-failure, nih, overdistension-detection, pediatric-ventilation, volume-pressure-curve
Organization: U.S. Department of Health & Human Services
2018 National Directory of Drug and Alcohol  Abuse Treatment Facilities

The National Directory of Drug and Alcohol Abuse Treatment Facilities - 2018 is a listing of federal, state, andlocal government facilities and private facilities that provide substance abuse treatment services. It includestreatment facilities that (1) are licensed, certified, or otherwise approved for inclusion in the Directory by theirState Substance Abuse Agencies, and (2) responded to the 2017 National Survey of Substance Abuse TreatmentServices (N-SSATS). The information about each facility that appears in this Directory was provided by thatfacility in response to the 2017 N-SSATS. N-SSATS is conducted annually by the Substance Abuse and MentalHealth Services Administration (SAMHSA).The Directory is ordered alphabetically by state, by city within each state, and by facility name within each city.Each facility listing includes codes that represent the services offered and other features of the facility, including codes that indicate services for hearing impaired and non-English-speaking clients. Codes are defined in a key shown on pages v-vii. Because the services offered by a particular facility may change over time, it is always a good idea to verify the information in this Directory when contacting a facility.

Tags: alcohol-abuse, drug-abuse, samhsa, substance-abuse-treatment, treatment-facilities
Organization: U.S. Department of Health & Human Services