AndreaBozzo/ceres-open-data-index huggingface dataset:
Behavioral Health Barometer: Alabama, 2015

This is a behavioral health report for the state of Alabama. The report utilizes data from the National Survey on Drug Use and Health (NSDUH), and the Uniform Reporting System. The topics addressed in the report include youth substance use, youth mental health and treatment,and substance use and substance use treatment.

Tags: alabama-behavioral-health, mental-health-treatment, nsduh-data, samhsa, youth-substance-use
Organization: U.S. Department of Health & Human Services
2011 CMHS Uniform Reporting System (URS) Output Tables for West Virginia

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2011. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, outcome-measures, samhsa, west-virginia
Organization: U.S. Department of Health & Human Services
Pooling, meta-analysis, and the evaluation of drug safety

Background
          The "integrated safety report" of the drug registration files submitted to health authorities usually summarizes the rates of adverse events observed for a new drug, placebo or active control drugs by pooling the safety data across the trials. Pooling consists of adding the numbers of events observed in a given treatment group across the trials and dividing the results by the total number of patients included in this group. Because it considers treatment groups rather than studies, pooling ignores validity of the comparisons and is subject to a particular kind of bias, termed "Simpson's paradox." In contrast, meta-analysis and other stratified analyses are less susceptible to bias.
        
        
          Methods
          We use a hypothetical, but not atypical, application to demonstrate that the results of a meta-analysis can differ greatly from those obtained by pooling the same data. In our hypothetical model, a new drug is compared to 1) a placebo in 4 relatively small trials in patients at high risk for a certain adverse event and 2) an active reference drug in 2 larger trials of patients at low risk for this event.
        
        
          Results
          Using meta-analysis, the relative risk of experiencing the adverse event with the new drug was 1.78 (95% confidence interval [1.02; 3.12]) compared to placebo and 2.20 [0.76; 6.32] compared to active control. By pooling the data, the results were, respectively, 1.00 [0.59; 1.70] and 5.20 [2.07; 13.08].
        
        
          Conclusions
          Because these findings could mislead health authorities and doctors, regulatory agencies should require meta-analyses or stratified analyses of safety data in drug registration files.

Tags: adverse-events, drug-safety, meta-analysis, nih, simpsons-paradox
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Montana, 2015

This is a behavioral health report for the state of Montana. The report utilizes data from the National Survey on Drug Use and Health (NSDUH), and the Uniform Reporting System. The topics addressed in the report include youth substance use, youth mental health and treatment, mental health and treatment, substance use and substance use treatment.

Tags: mental-health-treatment, montana-behavioral-health, nsduh-data, samhsa, youth-substance-use
Organization: U.S. Department of Health & Human Services
Mouse skin passage of a

Background
          Streptolysin S (SLS), the oxygen-stable hemolysin of Streptococcus pyogenes, has recently been shown to be encoded by the sagA/pel gene. Mutants lacking expression of this gene were less virulent in a dermonecrotic mouse infection model. Inactivation of the sagA/pel gene affect the expression of a variety of virulence factors in addition to the hemolysin. Insertion of a Tn917 transposon into the promoter region of the sagA/pel gene of S. pyogenes isolate CS101 eliminated expression of SLS, as well as decreased expression of the streptococcal pyrogenic exotoxin B, streptokinase and M protein.
        
        
          Results
          In this study a mouse skin air sac model was utilized to analyze the effect of biological pressures on expression of SLS and other sagA/pel regulated gene products. The insertion delayed the lethal effect of S. pyogenes in a mouse skin infection model. Despite this, bacteria could be cultured from the kidneys 72 hours post infection. These kidney-recovered isolates were β-hemolytic despite the transposon being present in its original location and had equivalent virulence to the wild type isolate when re-injected into naive mice. Northern blot analysis of the kidney-recovered isolates confirmed that transcription of sagA/pel was restored; however the expression of all sagA/pel regulated genes was not restored to wild type levels.
        
        
          Conclusions
          These results show that biological pressure present in the mouse can select for variants with altered expression of key virulence factor genes in S. pyogenes.

Tags: mouse-model, nih, streptococcus-pyogenes, streptolysin-s, virulence-factors
Organization: U.S. Department of Health & Human Services
2017 Uniform Reporting System (URS) Table for Wisconsin

This is the 2017 Uniform Reporting System (URS) Output Tables for Wisconsin. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant, evidence-based-practices, mental-health-services, outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Table 23. 2011-2012 NSDUH Serious Mental Illness in the Past Year, by Age Group and State

Table 23. Serious Mental Illness in the Past Year, by Age Group and State: Percentages, Annual Averages Based on 2011 and 2012 NSDUHs. Results are provided by State and for four age groups: 18 to 25, 26 or older, 18 or older and all persons 18 or older.

Tags: age-group-analysis, mental-health-prevalence, nsduh-data, samhsa, serious-mental-illness
Organization: U.S. Department of Health & Human Services
Evidence for the involvement of G

Background
          Activation of the extracellular signal-regulated kinases ERK1 and ERK2 in hepatocytes by prostaglandin (PG)F2α was recently found to be inhibited by pertussis toxin (PTX) suggesting a role for Gi proteins.
        
        
          Results
          Targeting the Gi2α expression by a specific ribozyme inhibited the PGF2α -induced ERK1/2 activation in hepatocytes. On the other hand a non-cleaving form of the Gi2α ribozyme did not significantly decrease the ERK1/2 activation. In ribozyme-treated cells the Gi2α protein level was reduced, while the Gqα level was not affected thus confirming the specificity of the ribozyme.
        
        
          Conclusion
          The present data suggest an important role of Gi2 in PGF2α -induced ERK1/2 signaling in hepatocytes.

Tags: erk12-signaling, gi2-protein, hepatocytes, nih, prostaglandin-f2alpha
Organization: U.S. Department of Health & Human Services
Investigation of glutathione

Background
          Certain genes from the glutathione S-transferase superfamily have been associated with several cancer types. It was the objective of this study to determine whether alleles of the glutathione S-transferase zeta 1 (GSTZ1) gene are associated with the development of sporadic breast cancer.
        
        
          Methods
          DNA samples obtained from a Caucasian population affected by breast cancer and a control population, matched for age and ethnicity, were genotyped for a polymorphism of the GSTZ1 gene. After PCR, alleles were identified by restriction enzyme digestion and results analysed by chi-square and CLUMP analysis.
        
        
          Results
          Chi-squared analysis gave a χ2 value of 4.77 (three degrees of freedom) with P = 0.19, and CLUMP analysis gave a T1 value of 9.02 with P = 0.45 for genotype frequencies and a T1 value of 4.77 with P = 0.19 for allele frequencies.
        
        
          Conclusion
          Statistical analysis indicates that there is no association of the GSTZ1 variant and hence the gene does not appear to play a significant role in the development of sporadic breast cancer.

Tags: breast-cancer, case-control-study, genetic-polymorphism, glutathione-transferase, nih
Organization: U.S. Department of Health & Human Services
2022 Uniform Reporting System (URS) Table For Oregon

This is the 2022 Uniform Reporting System (URS) Output Tables for Oregon. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-data, mental-health-services, noms-measures, oregon-state-data, samhsa
Organization: U.S. Department of Health & Human Services
New Orleans-Metairie-Kenner, LA

This report presents combined 2005 to 2010 National Survey on Drug Use and Health (NSDUH) results for those aged 12 or older in the New Orleans-Metairie-Kenner, LA metro area. The report includes estimates of substance use disorder, major depressive episode, illicit drug use, marijuana use, cigarette use, binge alcohol use, and the nonmedical use of prescription-type pain relievers. Results are provided for the New Orleans-Metairie-Kenner metro area, Louisiana, and the U.S. overall.

Tags: major-depressive-episode, new-orleans, nsduh, samhsa, substance-use-disorder
Organization: U.S. Department of Health & Human Services
Tetraethylammonium block of water flux in Aquaporin-1 channels expressed in kidney thin limbs of Henle's loop and a kidney-derived cell line.

Background
          Aquaporin-1 (AQP1) channels are constitutively active water channels that allow rapid transmembrane osmotic water flux, and also serve as cyclic-GMP-gated ion channels. Tetraethylammonium chloride (TEA; 0.05 to 10 mM) was shown previously to inhibit the osmotic water permeability of human AQP1 channels expressed in Xenopus oocytes. The purpose of the present study was to determine if TEA blocks osmotic water flux of native AQP1 channels in kidney, and recombinant AQP1 channels expressed in a kidney derived MDCK cell line. We also demonstrate that TEA does not inhibit the cGMP-dependent ionic conductance of AQP1 expressed in oocytes, supporting the idea that water and ion fluxes involve pharmacologically distinct pathways in the AQP1 tetrameric complex.
        
        
          Results
          TEA blocked water permeability of AQP1 channels in kidney and kidney-derived cells, demonstrating this effect is not limited to the oocyte expression system. Equivalent inhibition is seen in MDCK cells with viral-mediated AQP1 expression, and in rat renal descending thin limbs of Henle's loops which abundantly express native AQP1, but not in ascending thin limbs which do not express AQP1. External TEA (10 mM) does not block the cGMP-dependent AQP1 ionic conductance, measured by two-electrode voltage clamp after pre-incubation of oocytes in 8Br-cGMP (10–50 mM) or during application of the nitric oxide donor, sodium nitroprusside (2–4 mM).
        
        
          Conclusions
          TEA selectively inhibits osmotic water permeability through native and heterologously expressed AQP1 channels. The pathways for water and ions in AQP1 differ in pharmacological sensitivity to TEA, and are consistent with the idea of independent solute pathways within the channel structure. The results confirm the usefulness of TEA as a pharmacological tool for the analysis of AQP1 function.

Tags: aquaporin-1, kidney-cells, nih, tetraethylammonium, water-permeability
Organization: U.S. Department of Health & Human Services
Compound 528525: Hexadecane, 5-propyl

Chemical compound data from PubChem database. IUPAC Name: 5-propylhexadecane. Molecular Formula: C19H40. Molecular Weight: 268.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 527243: (7,7-Dimethyl-6-methylidene-2-tricyclo[6.2.1.01,5]undecanyl)methyl acetate

Chemical compound data from PubChem database. IUPAC Name: (7,7-dimethyl-6-methylidene-2-tricyclo[6.2.1.01,5]undecanyl)methyl acetate. Molecular Formula: C17H26O2. Molecular Weight: 262.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Wisconsin, 2015

This is a behavioral health report for the state of Wisconsin. The report utilizes data from the National Survey on Drug Use and Health (NSDUH), and the Uniform Reporting System. The topics addressed in the report include youth substance use, youth mental health and treatment, mental health and treatment, substance use and substance use treatment.

Tags: behavioral-health, mental-health, samhsa, substance-use, wisconsin
Organization: U.S. Department of Health & Human Services
The NSDUH Report: Need for and Receipt of Substance Use Treatment among Hispanics

This report uses 2003 to 2011 National Survey on Drug Use and Health (NSDUH) to assess past year need for and receipt of substance use treatment among Hispanics aged 12 or older in comparison to non-Hispanics.

Tags: hispanic-health, nsduh-data, samhsa, substance-use-treatment, treatment-gap
Organization: U.S. Department of Health & Human Services
Lessons Learned from Implementing Mobile Solutions

This DSS hosted webinar describes the lessons learned from implementing mobile solutions in Washington and in Minnesota, which is a state managed, county-administered state. The presentation included representatives from Winona County and Carver County Minnesota who spoke about their county-level mobile solutions.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: case, policy, scope, state, study
Organization: U.S. Department of Health & Human Services
2012 Uniform Reporting System (URS) Tables for Missouri

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2012. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, national-outcome-measures, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
Locations of several novel 2'-

Background
          Ribose 2'-O-methylation, the most common nucleotide modification in mammalian rRNA, is directed by the C/D box small nucleolar RNAs (snoRNAs). Thus far, more than fifty putative human rRNA methylation guide snoRNAs have been identified. For nine of these snoRNAs, the respective ribose methylations in human 28S rRNA have been only presumptive.
        
        
          Results
          In this study, the methylation state of human 28S rRNA in the positions predicted by the snoRNAs U21, U26, U31, U48, U50, U73, U74, U80 and U81 was assessed using reverse transcription-based methods and several novel 2'-O-methylations were localized.
        
        
          Conclusions
          Seven novel ribose 2'-O-methylated residues (Am389, Am391, Gm1604, Gm1739, Gm2853, Cm3810, Gm4156, predicted by snoRNAs U26, U81, U80, U73, U50, U74 and U31, respectively) have been localized in human 28S rRNA. The total number of 2'-O-methylations in human rRNA is not yet known.

Tags: nih, nucleotide-modification, ribose-methylation, rrna-methylation, snorna-guided
Organization: U.S. Department of Health & Human Services
Compound 525379: 2,5,5-Trimethyl-4-thiaheptane

Chemical compound data from PubChem database. IUPAC Name: 2-methyl-2-(2-methylpropylsulfanyl)butane. Molecular Formula: C9H20S. Molecular Weight: 160.32. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Treatment Episode Data Set (TEDS) Highlights - 2005 National Admissions to Substance Abuse Treatment Services

This report presents summary results from the Treatment Episode Data Set (TEDS) for 2005. The report provides information on the demographic and substance abuse characteristics of the 1.8 million people admitted to treatment for abuse of alcohol and drugs that year to facilities that report to individual state administrative data systems.

Tags: alcohol-drug-abuse, samhsa, substance-abuse-treatment, teds-admissions, treatment-episodes
Organization: U.S. Department of Health & Human Services
Table 3. Marijuana Use in the Past Month, by Age Group and State: Percentages, Annual Averages Based on 2013 and 2014 NSDUHs

Table 3. Marijuana Use in the Past Month, by Age Group and State: Percentages, Annual Averages Based on 2013 and 2014 NSDUHs

Tags: age-groups, marijuana-use, samhsa, state-level-data, substance-use
Organization: U.S. Department of Health & Human Services
New York City – 5 Boros: Drug-Related Emergency Department Visits, 2004-2011 - Illicits (excluding alcohol)

Excel file with estimates, rates, relative standard errors, trends and confidence intervals for all drug-related emergency department (ED) visits involving illicit drugs for New York City\'s 5 boroughs, covering 2004-2011. These visits involve the use of drugs that have limited or no therapeutic value and are generally illegal if taken without a prescription. It also includes visits involving the inhalation of substances for their psychoactive properties (e.g., sniffing model airplane glue).

Tags: drug-related-ed-visits, emergency-department, illicit-drug-use, nyc-boroughs, samhsa
Organization: U.S. Department of Health & Human Services
The NSDUH Report: Trends in Adolescent Substance Use and Perception of Risk from Substance Use

This report focuses on trends between 2002 and 2011 from the National Survey on Drug Use and Health (NSDUH) in risk perception and substance use among adolescents aged 12 to 17. Adolescents evaluated whether people risk physical and other harm when they drink alcohol, use marijuana, use cocaine, use LSD, and use heroin. Results are shown by year, adolescent substance use, age group, and gender.

Tags: adolescent-substance-use, nsduh, risk-perception, samhsa, youth-drug-use
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: State Barometers, 2014

This is a behavioral health report for the United States. The report utilizes data from the National Survey on Drug Use and Health (NSDUH), the Youth Risk Behavior Survey (YRBS), the Monitoring of the Future Survey sponsored by the National Institute on Drug Abuse. . The topics addressed in the report include youth substance use, youth mental health and treatment, adult mental health and treatment, substance use, and substance use treatment.

Tags: behavioral-health, mental-health, samhsa, substance-use, youth-risk-behavior
Organization: U.S. Department of Health & Human Services
2013 CMHS Uniform Reporting System (URS) Table for Nebraska

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Tables for Nebraska for 2013. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program.  State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, nebraska, noms-measures, samhsa
Organization: U.S. Department of Health & Human Services
Compound 525233: 1-[10-[3-(Dimethylamino)propyl]phenothiazin-2-yl]ethanol

Chemical compound data from PubChem database. IUPAC Name: 1-[10-[3-(dimethylamino)propyl]phenothiazin-2-yl]ethanol. Molecular Formula: C19H24N2OS. Molecular Weight: 328.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Tobacco Product and Alcohol Use Tables (Standard Errors and P Values) - 2.1 to 2.84

These detailed tables present standard errors for totals and prevalence estimates of tobacco and alcohol use from the 2012 National Survey on Drug Use and Health (NSDUH). Tobacco products include cigarettes, smokeless tobacco, cigars, and pipe tobacco. Alcohol use includes binge and heavy alcohol use. Standard errors are provided for lifetime, past year, and past month use by age group, gender, race/ethnicity, education level, employment status, and geographic area. Standard errors are provided for both 2012 and 2011.

Tags: nsduh-2012, samhsa, standard-errors, substance-use-prevalence, tobacco-alcohol-use
Organization: U.S. Department of Health & Human Services
Compound 525051: N-(3-chloro-4-methylphenyl)pentanamide

Chemical compound data from PubChem database. IUPAC Name: N-(3-chloro-4-methylphenyl)pentanamide. Molecular Formula: C12H16ClNO. Molecular Weight: 225.71. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Rheumatoid arthritis, gold therapy, contact allergy and blood cytokines

Objective
          To study the clinical and biochemical effects of a low starting dose for gold therapy in rheumatoid arthritis patients with a contact allergy to gold.
        
        
          Methods
          Serum cytokines were assayed before and 24 h after the first injection of gold sodium thiomalate (GSTM).
        
        
          Results
          Contact allergy to gold was found in 4 of 19 patients. Compared to gold-negative patients (starting dose: 10 mg GSTM), there was a larger increase in serum TNFalpha (p < 0.05), sTNF-R1 (NS), and IL-1 ra (p < 0.05) in gold-allergic patients.
        
        
          Conclusions
          Cytokines are released in blood by GSTM in RA patients with gold allergy. To minimize the risk of acute adverse reactions the starting dose of GSTM should be lowered to 5 mg. Alternatively, patients should be patch-tested before gold therapy; in test-positive cases, 5 mg is recommended as the first dose.

Tags: contact-allergy, gold-therapy, nih, rheumatoid-arthritis, serum-cytokines
Organization: U.S. Department of Health & Human Services