AndreaBozzo/ceres-open-data-index huggingface dataset:
MPN+, a putative catalytic motif found in a subset of MPN domain proteins from eukaryotes and prokaryotes, is critical for Rpn11 function

Background
          Three macromolecular assemblages, the lid complex of the proteasome, the COP9-Signalosome (CSN) and the eIF3 complex, all consist of multiple proteins harboring MPN and PCI domains. Up to now, no specific function for any of these proteins has been defined, nor has the importance of these motifs been elucidated. In particular Rpn11, a lid subunit, serves as the paradigm for MPN-containing proteins as it is highly conserved and important for proteasome function.
        
        
          Results
          We have identified a sequence motif, termed the MPN+ motif, which is highly conserved in a subset of MPN domain proteins such as Rpn11 and Csn5/Jab1, but is not present outside of this subfamily. The MPN+ motif consists of five polar residues that resemble the active site residues of hydrolytic enzyme classes, particularly that of metalloproteases. By using site-directed mutagenesis, we show that the MPN+ residues are important for the function of Rpn11, while a highly conserved Cys residue outside of the MPN+ motif is not essential. Single amino acid substitutions in MPN+ residues all show similar phenotypes, including slow growth, sensitivity to temperature and amino acid analogs, and general proteasome-dependent proteolysis defects.
        
        
          Conclusions
          The MPN+ motif is abundant in certain MPN-domain proteins, including newly identified proteins of eukaryotes, bacteria and archaea thought to act outside of the traditional large PCI/MPN complexes. The putative catalytic nature of the MPN+ motif makes it a good candidate for a pivotal enzymatic function, possibly a proteasome-associated deubiquitinating activity and a CSN-associated Nedd8/Rub1-removing activity.

Tags: mpn-domain, nih, proteasome-lid, rpn11-function, site-directed-mutagenesis
Organization: U.S. Department of Health & Human Services
Connecting the Dots to Prevent the Sexual Abuse of Children Through Collaboration

This webinar explored how the collaboration of child welfare organizations can strengthen and fortify efforts to prevent child sexual abuse. Representatives from two such organizations discussed their methods and successes in research, promoting community awareness and involvement, training and education, juvenile justice, funding strategies, and more.

Presenters: Pat Patrick, Vice President of Prevention and Education, Darkness to Light; Deborah Donovan Rice, Executive Director, Stop It Now!

View Webinar (WMV - 69 MB)

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: abuse, child, policy, prevention, scope
Organization: U.S. Department of Health & Human Services
Compound 528345: (2,3-Dichlorophenoxy)(trimethyl)silane

Chemical compound data from PubChem database. IUPAC Name: (2,3-dichlorophenoxy)-trimethylsilane. Molecular Formula: C9H12Cl2OSi. Molecular Weight: 235.18. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 525639: N,N-Dimethyl-N'-octyl-p-chlorobenzamidine

Chemical compound data from PubChem database. IUPAC Name: 4-chloro-N,N-dimethyl-N'-octylbenzenecarboximidamide. Molecular Formula: C17H27ClN2. Molecular Weight: 294.9. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 525224: Chloromethyl 7-chloro-octanoate

Chemical compound data from PubChem database. IUPAC Name: chloromethyl 7-chlorooctanoate. Molecular Formula: C9H16Cl2O2. Molecular Weight: 227.12. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2016 Uniform Reporting System (URS) Table for West Virginia

This is the 2016 Uniform Reporting System (URS) Output Tables for West Virginia. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: mental-health-services, national-outcome-measures, samhsa, substance-abuse-treatment, west-virginia
Organization: U.S. Department of Health & Human Services
Compound 527360: 18,22,26-Trimethyl-nonacosyl cyanide

Chemical compound data from PubChem database. IUPAC Name: 19,23,27-trimethyltriacontanenitrile. Molecular Formula: C33H65N. Molecular Weight: 475.9. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 525523: (3-Chloro-4-benzyloxy-phenyl)-propionic acid, methyl ester

Chemical compound data from PubChem database. IUPAC Name: methyl 3-(3-chloro-4-phenylmethoxyphenyl)propanoate. Molecular Formula: C17H17ClO3. Molecular Weight: 304.8. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Pennsylvania, 2015

This is a behavioral health report for the state of Pennsylvania. The report utilizes data from the National Survey on Drug Use and Health (NSDUH), and the Uniform Reporting System. The topics addressed in the report include youth substance use, youth mental health and treatment, mental health and treatment, substance use and substance use treatment.

Tags: mental-health-treatment, nsduh-data, pennsylvania-behavioral-health, samhsa, youth-substance-use
Organization: U.S. Department of Health & Human Services
Changes to the Personal Responsibility and Work Opportunity Reconciliation Act of 1996 (Public Law (P.L.) 104-193

The purpose of this Information Memorandum (IM) is to inform title IV-E agencies of changes to PRWORA that permit citizens of “freely associated states” to be “qualified aliens” thereby, potentially eligible for title IV-E programs.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: child, legal, policy, right, scope
Organization: U.S. Department of Health & Human Services
Compound 525249: N''-(4-iodo-phenyl)-N,N,N',N'-tetramethyl-guanidine

Chemical compound data from PubChem database. IUPAC Name: 2-(4-iodophenyl)-1,1,3,3-tetramethylguanidine. Molecular Formula: C11H16IN3. Molecular Weight: 317.17. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 528389: 4,5-Dichloro-2-hydroxybenzaldehyde

Chemical compound data from PubChem database. IUPAC Name: 4,5-dichloro-2-hydroxybenzaldehyde. Molecular Formula: C7H4Cl2O2. Molecular Weight: 191.01. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2015 CMHS Uniform Reporting System (URS) Table for Utah

2015 Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for Utah. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, outcome-measures, samhsa, utah-mental-health
Organization: U.S. Department of Health & Human Services
Table 13. Binge Alcohol Use in the Past Month among Persons Aged 12 to 20, by State and Substate Regions: Percentages, Annual Averages Based on 2010, 2011, and 2012 NSDUHs

Table 13. Binge Alcohol Use in the Past Month among Persons Aged 12 to 20, by State and Substate Regions: Percentages, Annual Averages Based on 2010, 2011, and 2012 NSDUHs

Tags: adolescent-alcohol-use, binge-drinking, nsduh, samhsa, youth-alcohol-consumption
Organization: U.S. Department of Health & Human Services
Compound 525415: 2-Methyl-4,6-dithiaoctane

Chemical compound data from PubChem database. IUPAC Name: 1-(ethylsulfanylmethylsulfanyl)-2-methylpropane. Molecular Formula: C7H16S2. Molecular Weight: 164.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
18 Percent of Pregnant Women Drink Alcohol during Early Pregnancy (2011 to 2012 NSDUH)

This report uses 2011 to 2012 National Survey on Drug Use and Health (NSDUH) to assess past month alcohol use and binge alcohol use among pregnant women aged 15 to 44 by trimester of pregnancy.

Tags: alcohol-use, binge-drinking, nsduh, pregnancy, samhsa
Organization: U.S. Department of Health & Human Services
Possible association of β

Background
          The involvement of β2-adrenergic receptor (ADRB2) and β3-adrenergic receptor (ADRB3) in both adipocyte lipolysis and thermogenic activity suggests that polymorphisms in the encoding genes might be linked with interindividual variation in obesity, an important risk factor for postmenopausal breast cancer. In order to examine the hypothesis that genetic variations in ADRB2 and ADRB3 represent interindividual susceptibility factors for obesity and breast cancer, we conducted a hospital-based, case-control study in the Aichi Cancer Center, Japan.
        
        
          Methods
          A self-administered questionnaire was given to 200 breast cancer patients and 182 control individuals, and pertinent information on lifestyle, family history and reproduction was collected. ADRB2 and ADRB3 genotypes were determined by polymerase chain reaction (PCR) restriction fragment length polymorphism assessment.
        
        
          Results
          Twenty-five (12.4%) breast cancer patients and 32 (17.6%) control individuals were found to bear a glutamic acid (Glu) allele for the ADRB2 gene (odds ratio [OR] 0.67, 95% confidence interval [CI] 0.38-1.18), and 60 (30.0%) breast cancer patients and 61 (33.5%) control individuals were found to bear an Arg allele for the ADRB3 gene (OR 0.85, 95% CI 0.55-1.31). A significantly lower risk was observed in those who carried the Glu ADRB2 allele and who reported first childbirth when they were younger than 25 years (OR 0.35; 95% CI 0.13-0.99).
        
        
          Conclusion
          A potential association may exist between risk of breast cancer and polymorphisms in the ADRB2 and ADRB3 genes; further studies in larger samples and/or in different ethnic groups are warranted to investigate this potential association.

Tags: adrenergic-receptor, breast-cancer, case-control-study, genetic-polymorphism, nih
Organization: U.S. Department of Health & Human Services
New Jersey 2016 Potential Areas for Addressing Service Gaps for Opioid Treatment

The purpose of the medication-assisted treatment (MAT) facility maps is to identify areas on a state-by-state basis that may be potentially underserved by existing treatment facilities. The maps are created with a methodology that seeks to include the highest potential need areas from individual counties so that county-level stakeholders are also informed. The maps are meant to be used as a tool for policy makers to determine potentially underserved areas—not as a definitive representation of these areas.

Tags: mat-access, new-jersey, opioid-treatment, samhsa, service-gap-analysis
Organization: U.S. Department of Health & Human Services
2018 Uniform Reporting System (URS) Table for Louisiana

This is the 2018 Uniform Reporting System (URS) Output Tables for Louisiana. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-program, mental-health-services, national-outcome-measures, samhsa, substance-abuse-treatment
Organization: U.S. Department of Health & Human Services
2016 NSDUH:  Race and Ethnicity Summary Sheets

This is a series of five summary sheets that list substance use and mental health estimates for Asians, Blacks or African Americans, Hispanic or Latinos, Native Hawaiian or Other Pacific Islanders, and American Indian or Alaskan Natives.

Tags: mental-health, nsduh-2016, racial-ethnic-groups, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Miami - Fort Lauderdale Div: Drug-Related Emergency Department Visits, 2008-2011 - Illicits (excluding alcohol)

Excel file with estimates, rates, relative standard errors, trends and confidence intervals for all drug-related emergency department (ED) visits involving illicit drugs for the Miami metropolitan area, Fort Lauderdale division, covering 2008-2011. These visits involve the use of drugs that have limited or no therapeutic value and are generally illegal if taken without a prescription. It also includes visits involving the inhalation of substances for their psychoactive properties (e.g., sniffing model airplane glue).

Tags: drug-related-ed-visits, emergency-department-data, illicit-drug-use, miami-fort-lauderdale, samhsa
Organization: U.S. Department of Health & Human Services
Mesenchymally-derived Insulin-like growth factor 1 provides a paracrine stimulus for trophoblast migration

Background
          Trophoblast migration into maternal decidua is essential for normal pregnancy. It occurs in a defined time window, is spatially highly restricted, and is aberrant in some pathological pregnancies, but the control mechanisms are as yet ill-defined. At the periphery of the placenta, chorionic villi make contact with decidua to form specialised anchoring sites that feed interstitially migrating cytotrophoblast into the placental bed.
        
        
          Results
          Explants of first trimester mesenchymal villi on collagen type I developed cytotrophoblast outgrowths from the villous tips. However, in medium changed daily, cells did not progress to a migratory phenotype, remaining instead as a contiguous multi-layered sheet. This suggested the need for another migration stimulus. To test the possibility that this might arise from mesenchymal cells, serum-free conditioned medium from first trimester placental fibroblasts was added to explant cultures. Cytotrophoblasts were stimulated to migrate in streams across the gel. Affinity depletion of Insulin-like growth factor from fibroblast medium reduced streaming activity, while the addition of exogenous IGF-I (10 ng/ml) to serum-free medium produced a streaming phenotype. IGF receptor type 1 (IGFR1) was present on cells in the columns, and streaming could be inhibited by antibody to this receptor. IGF-II and activin, known stimulators of cytotrophoblast migration, were also active in this model.
        
        
          Conclusions
          These data suggest a paracrine interaction between villous mesenchyme and the cytotrophoblast in anchoring sites that stimulates trophoblast infiltration of decidua. Such a signal would be self-limiting since it diminishes with distance from the placenta. This is a novel mechanism in placental development.

Tags: cytotrophoblast-outgrowths, first-trimester, nih, placental-bed, trophoblast-migration
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Missouri, 2014

This is a behavioral health report for the state of Missouri. It uses the National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment Services (NSSATS) to address the topics of youth substance use, youth mental health and treatment, adult mental health and treatment, substance use, and substance use treatment for the years 2009 to 2013.

Tags: mental-health-missouri, missouri-behavioral-health, samhsa, substance-use-trends, youth-behavioral-health
Organization: U.S. Department of Health & Human Services
2012 NSDUH Instrumentation Protocol Changes

This report documents instrumentation protocol changes occurring between the 2011 National Survey on Drug Use and Health (NSDUH) and the 2012 NSDUH. This summary document is divided into three topics: 1) computer-assisted interviewing (CAI) screening instrument, 2) the CAI Questionnaire, and 3) the interviewer materials.

Tags: nsduh, protocol-changes, samhsa, substance-use, survey-methodology
Organization: U.S. Department of Health & Human Services
Compound 528412: Flavone, 3,5,7-trihydroxy, bis-TMS

Chemical compound data from PubChem database. IUPAC Name: 3-hydroxy-2-phenyl-5,7-bis(trimethylsilyloxy)chromen-4-one. Molecular Formula: C21H26O5Si2. Molecular Weight: 414.6. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Monthly Caseworker Visit (funds)

Program Description:

Title IV-B, subpart 2 of the Social Security Act sets aside funding for formula grants to help states improve the quality of caseworker visits with children in foster care, with an emphasis on improving caseworker decision-making on the safety, permanency, and well-being of children in foster children and caseworker recruitment, retention and training.

Budget Information

Standards for Caseworker Visits

The law also sets performance standards for caseworker visits and requires states to submit annual data on the percentage of children in foster care receiving monthly caseworker visits and the percentage of such visits occurring in the residence of the child.  Since FY 2015 states have been required to ensure the total number of monthly caseworker visits is not less than 95 percent of the total visits that would be made if each child in foster care were visited once per month.  In addition, at least 50 percent of the total number of monthly visits made by caseworkers to children in foster care must occur in the child’s residence.

States that do not meet the performance targets are subject to reductions in the rate of Federal Financial Participation (FFP) under the title IV-B, subpart 1 program (Stephanie Tubbs Jones Child Welfare Services Program).  Reductions in FFP may range from one to five percentage points for each performance measure, depending on the extent to which the expected level was not achieved.  States may continue to receive their full federal grant award but must provide a higher state match to receive the full funding.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: care, fiscal, foster, grant, policy
Organization: U.S. Department of Health & Human Services
Working With the Correctional System and Incarcerated Parents

This Child Welfare Information Gateway Podcast is available on Apple Podcasts
  
  

, GooglePlay
  
  

, Spotify
  
  

, Stitcher
  
  

, SoundCloud
  
  

, and the Child Welfare Information Gateway
  
  

 website. Subscribe to receive new episodes as they are released.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: child, justice, podcast, policy, social
Organization: U.S. Department of Health & Human Services
Patients with Drug-Related Emergency Department Visits Involving Suicide Attempts Who Left Against Medical Advice

This short report from the Drug Abuse Warning Network examines emergency department (ED) visits that involved a drug-related suicide attempt. It looks at the characteristics of the ED visits where the patient left against medical advice (before the ED visit was completed). It discusses how patients who left the ED before their treatment was completed may have missed a critical opportunity to receive medical follow-up.

Tags: drug-related-ed-visits, emergency-department, left-against-medical-advice, samhsa, suicide-attempts
Organization: U.S. Department of Health & Human Services
Pre-dialysis clinic attendance improves quality of life among hemodialysis patients

Background
          Although previous research has demonstrated that referral to pre-dialysis clinics is associated with favourable objective outcomes, the benefit of a pre-dialysis clinic from the perspective of patient-perceived subjective outcomes, such as quality of life (QOL), is less well defined.
        
        
          Methods
          A retrospective incident cohort study was conducted to determine if pre-dialysis clinic attendance was a predictor of better QOL scores measured within the first six months of hemodialysis (HD) initiation. Inclusion criteria were HD initiation from January 1 1998 to January 1 2000, diagnosis of chronic renal failure, and completion of the QOL questionnaire within six months of HD initiation. Patients receiving HD for less than four weeks were excluded. An incident cohort of 120 dialysis patients was identified, including 74 patients who attended at least one pre-dialysis clinic and 46 patients who did not. QOL was measured using the SF 36-Item Health Survey. Independent variables included age, sex, diabetes, pre-dialysis clinic attendance and length of attendance, history of ischemic heart disease, stroke, peripheral vascular disease, heart failure, malignancy, and chronic lung disease, residual creatinine clearance at dialysis initiation, and kt/v, albumin and hemoglobin at the time of QOL assessment. Bivariate and multivariate linear regression analyses were used to identify predictors of QOL scores.
        
        
          Results
          Multivariate analysis suggested that pre-dialysis clinic attendance was an independent predictor of higher QOL scores in four of eight health domains (physical function, p < 0.01; emotional role limitation, p = 0.01; social function, p = 0.01; and general health, p = 0.03), even after statistical adjustment for age, sex, residual renal function, kt/v, albumin, and co-morbid disease. Pre-dialysis clinic attendance was also an independent predictor of the physical component summary score (p = 0.03).
        
        
          Conclusions
          We conclude that pre-dialysis clinic attendance favourably influences patient-perceived quality of life within six months of dialysis initiation.

Tags: chronic-renal-failure, hemodialysis-patients, nih, pre-dialysis-care, quality-of-life
Organization: U.S. Department of Health & Human Services