AndreaBozzo/ceres-open-data-index huggingface dataset:
MHC class I multimers

T lymphocytes play a key role in the immune response to both foreign and self peptide antigens, which they recognize in combination with MHC molecules. In the past it has been difficult to analyse objectively the specificity, frequency and intensity of T cell responses. The recent application of fluorescent-labelled MHC class I multimers, however, has provided a powerful experimental approach to the direct visualisation of antigen-specific T cells. As a result, our perspective of how T cells respond to both viruses and other antigens in vivo has been greatly enhanced.

Tags: antigen-specific-t-cells, immune-response, mhc-class-i, nih, t-lymphocytes
Organization: U.S. Department of Health & Human Services
Sex steroids do not affect shigatoxin cytotoxicity on human renal tubular or glomerular cells

Background
          The greater susceptibility of children to renal injury in post-diarrheal hemolytic-uremic syndrome (HUS) may be related, at least in part, to heightened renal cell sensitivity to the cytotoxic effect of Shiga toxin (Stx), the putative mediator of kidney damage in HUS. We hypothesized that sexual maturation, which coincides with a falling incidence of HUS, may induce a relatively Stx-resistant state in the renal cells.
        
        
          Methods
          Cultured human glomerular endothelial (HGEN), human glomerular visceral epithelial (HGEC) and human proximal tubule (HPT) cells were exposed to Stx-1 after pre-incubation with progesterone, β-estradiol or testosterone followed by determination of cytotoxicity.
        
        
          Results
          Under basal conditions, Stx-1 potently and dose-dependently killed HPT and HGEC, but had relatively little effect on HGEN. Pre-incubation for 1, 2 or 7 days with physiologic or pharmacologic concentrations of progesterone, β-estradiol or testosterone had no effect on Stx-1 cytotoxicity dose-response on any cell type. In addition, no steroid altered Gb3 expression (Stx receptor) by any cell type at any time point.
        
        
          Conclusion
          These data do not support the notion that hormonal changes associated with puberty induce an Stx-resistant state within kidney cells.

Tags: cytotoxicity, nih, renal-cells, sex-steroids, shiga-toxin
Organization: U.S. Department of Health & Human Services
Depression Triples between the Ages of 12 and 15 among Adolescent Girls

This spotlight uses 2008 to 2010 National Surveys on Drug Use and Healthto examine the percentage of girls aged 12 to 17 who experienced a major depressive episode (MDE) in the past year and received treatment. for depression in the past year.

Tags: adolescent-depression, major-depressive-episode, mental-health-treatment, nsduh-data, samhsa
Organization: U.S. Department of Health & Human Services
Publications Using SAMHSA DataTobacco Product and Alcohol Use Tables (Standard Errors and P Values) - 2.1 to 2.84

These detailed tables present standard errors for totals and prevalence estimates of tobacco and alcohol use from the 2011 National Survey on Drug Use and Health (NSDUH). Tobacco products include cigarettes, smokeless tobacco, cigars, and pipe tobacco. Alcohol use includes binge and heavy alcohol use. Standard errors are provided for lifetime, past year, and past month use by age group, gender, race/ethnicity, education level, employment status, and geographic area. Standard errors are provided for both 2011 and 2010.

Tags: nsduh-survey-data, samhsa, standard-error-estimates, substance-use-prevalence, tobacco-alcohol-use
Organization: U.S. Department of Health & Human Services
Anti-atherogenic effects of fibrates in type 2 diabetes

Type 2 diabetes is an increasing cause of premature coronary heart disease. Several trials with lipid-modifying therapy have included sufficient numbers of diabetics to indicate that treatment of diabetic dyslipidaemia with either fibrates or statins reduces the risk of future coronary events in such patients. However, until recently no reported study had been designed specifically to investigate the effects of intervening in patients with type 2 diabetes. The Diabetes Atherosclerosis Intervention Study (DAIS) is an angiographic study in which 418 diabetic subjects were randomized to micronised fenofibrate or placebo groups. After 3 years of treatment, the fenofibrate group had a significantly reduced rate of progression of coronary atherosclerosis. This study, when considered with the results of other studies that have included diabetics, has important implications for the treatment of diabetic dyslipidaemia. The evidence that is currently available supports a place for both fibrates and statins, either as monotherapy or in combination, in the treatment of diabetic dyslipidaemia.

Tags: atherosclerosis-progression, cardiovascular-disease, fenofibrate-treatment, nih, type-2-diabetes
Organization: U.S. Department of Health & Human Services
Compound 525382: 2,5,6-Trimethyl-3,4-dithiaheptane

Chemical compound data from PubChem database. IUPAC Name: 2-methyl-3-(propan-2-yldisulfanyl)butane. Molecular Formula: C8H18S2. Molecular Weight: 178.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Incidence Tables (Prevalence Estimates) - 4.1 to 4.16

These detailed tables present totals and prevalence estimates of substance use initiation from the 2012 National Survey on Drug Use and Health (NSDUH). Substances examined include illicit drugs (e.g., marijuana, cocaine, heroin, hallucinogens (including LSD, PCP, Ecstasy), inhalants, and the nonmedical use of prescription-type pain relievers (including OxyContin), tranquilizers, stimulants, sedatives, alcohol, and tobacco products (including cigarettes, smokeless tobacco, and cigars). Results are provided by age group and gender. Estimates are provided for both 2012 and 2011

Tags: initiation-rates, nsduh-2012, prevalence-estimates, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Compound 525103: 1,3-Dichloroisopropyl propionate

Chemical compound data from PubChem database. IUPAC Name: 1,2-dichloropropan-2-yl propanoate. Molecular Formula: C6H10Cl2O2. Molecular Weight: 185.05. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Comparison Between 2021-2022 NSDUH State Prevalence Estimates

Compare state and regional estimates for 35 measures of substance use and mental health using p-values. The tables are a companion to thestate-level estimatesfrom the 2021-2022 National Surveys on Drug Use and Health (NSDUH). This collection consists of several sets of p-value tables, along with a guide for their use in determining if differences between two geographic areas are statistically significant.

Tags: mental-health, samhsa, state-prevalence, statistical-significance, substance-use
Organization: U.S. Department of Health & Human Services
Compound 528437: 1-Decene, 4-ethyl

Chemical compound data from PubChem database. IUPAC Name: 4-ethyldec-1-ene. Molecular Formula: C12H24. Molecular Weight: 168.32. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Dallas-Fort Worth-Arlington, TX

This report presents combined 2005 to 2010 National Survey on Drug Use and Health (NSDUH) results for those aged 12 or older in the Dallas-Fort Worth-Arlington, TX metro area. The report includes estimates of substance use disorder, major depressive episode, illicit drug use, marijuana use, cigarette use, binge alcohol use, and the nonmedical use of prescription-type pain relievers. Results are provided for the Dallas-Fort Worth-Arlington metro area, Texas, and the U.S. overall.

Tags: dallas-fort-worth, major-depressive-episode, nsduh, samhsa, substance-use-disorder
Organization: U.S. Department of Health & Human Services
Miami

Data tables consisting of Excel files with estimates, rates, relative standard errors, trends and confidence intervals, covering 2004-2011, for drug-related emergency department visits for the Miami-Dade Division of the Miami Metropolitan Statistical Area. Tables are provided for 10 topics (\"analytic categories\") which are defined in the \"Guide to Drug Abuse Warning Trend Tables,\" a separate document.   Each table includes data for over 500 drugs, including illicit drugs, prescription and over-the-counter medications, dietary supplements, inhalants and alcohol. Includes total visits, gender, age group, race/ethnicity, outcome of visit, drug combinations, number of drugs involved in visit, drug frequency, and drugs confirmed by toxicology. Additional detail is provided for illicit drugs, psychotherapeutic drugs, central nervous system (CNS) drugs, respiratory drugs and cardiovascular drugs.

Tags: drug-abuse-trends, drug-related-ed-visits, emergency-department, miami-dade, samhsa
Organization: U.S. Department of Health & Human Services
1 in 5 Parents Think What They Say Has Little Influence on Their Child\'s Substance Use (2004 to 2011 NSDUH)

This report uses 2004 to 2011 National Survey on Drug Use and Health (NSDUH) to assess whether parents of adolescents aged 12 to 17 thought what they said influenced whether their child used drugs and whether they talked to their child about the dangers of substance use.

Tags: adolescent-substance-use, drug-use-prevention, nsduh-data, parental-influence, samhsa
Organization: U.S. Department of Health & Human Services
Table 22. Needing But Not Receiving Treatment for Alcohol Use in the Past Year, by Age Group and State: Percentages, Annual Averages Based on 2013 and 2014 NSDUHs

Table 22. Needing But Not Receiving Treatment for Alcohol Use in the Past Year, by Age Group and State: Percentages, Annual Averages Based on 2013 and 2014 NSDUHs

Tags: alcohol-use-disorder, nsduh-data, samhsa, substance-use-treatment, unmet-treatment-need
Organization: U.S. Department of Health & Human Services
Compound 527262: Octanoic acid, 2-iodoethyl ester

Chemical compound data from PubChem database. IUPAC Name: 2-iodoethyl octanoate. Molecular Formula: C10H19IO2. Molecular Weight: 298.16. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Treatment Episode Data Set (TEDS): 2005-2015,  State Admissions to Substance Abuse Treatment Services

This report uses data from the Treatment Episode Data Set (TEDS) to examine treatment admission data in 2015, and trend data from 2005 to 2015, nationally, regionally (by four Census regions and nine Census divisions), and by state or jurisdiction. The report provides information on the demographic and substance abuse characteristics of admissions to treatment aged 12 and older for abuse of alcohol and/or drugs in facilities that report to individual state administrative data systems. It is important to note that values in charts, narrative lists, and percentage distributions are calculated using actual raw numbers and rounded for presentation in this report; calculations using rounded values may produce different results. For 2015, a total of 1,537,025 admissions aged 12 and older were reported to TEDS by 45 states, the District of Columbia, and Puerto Rico (Georgia, Kansas, Oregon, Pennsylvania, and South Carolina did not report sufficient admissions for 2015 to be included in this report).

Tags: alcohol-drug-abuse, samhsa, substance-abuse-treatment, teds-admissions, treatment-episodes
Organization: U.S. Department of Health & Human Services
Clinical evaluation of the Life Support for Trauma and Transport (LSTAT) platform

Introduction
          The Life Support for Trauma and Transport (LSTAT™) is a self-contained, stretcher-based miniature intensive care unit designed by the United States Army to provide care for critically injured patients during transport and in remote settings where resources are limited. The LSTAT contains conventional medical equipment that has been integrated into one platform and reduced in size to fit within the dimensional envelope of a North Atlantic Treaty Organization (NATO) stretcher. This study evaluated the clinical utility of the LSTAT in simulated and real clinical environments. Our hypothesis was that the LSTAT would be equivalent to conventional equipment in detecting and treating life-threatening problems.
        
        
          Methods
          Thirty-one anesthesiologists and recovery room nurses compared the LSTAT with conventional monitors while managing four simulated critical events. The time required to reach a diagnosis and treatment was recorded for each simulation. Subsequently, 10 consenting adult patients were placed on the LSTAT after surgery for postoperative care in the recovery room. Questionnaires about aspects of LSTAT functionality were completed by nine nurses who cared for the patients placed on the LSTAT.
        
        
          Results
          In all of the simulations, there was no clinically significant difference in the time to diagnosis or treatment between the LSTAT and conventional equipment. All clinicians reported that they were able to manage the simulated patients properly with the LSTAT. Nursing staff reported that the LSTAT provided adequate equipment to care for the patients monitored during recovery from surgery and were able to detect critical changes in vital signs in a timely manner.
        
        
          Discussion
          Preliminary evaluation of the LSTAT in simulated and postoperative environments demonstrated that the LSTAT provided appropriate equipment to detect and manage critical events in patient care. Further work in assessing LSTAT functionality in a higher-acuity environment is warranted.

Tags: critical-care-transport, medical-device-evaluation, military-medicine, nih, trauma-care
Organization: U.S. Department of Health & Human Services
Compound 525518: 2-(4-Cyclohexylmethoxy-phenyl)-propionic acid, methyl ester

Chemical compound data from PubChem database. IUPAC Name: methyl 2-(4-phenylmethoxyphenyl)propanoate. Molecular Formula: C17H18O3. Molecular Weight: 270.32. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2022 Uniform Reporting System (URS) Table For Hawaii

This is the 2022 Uniform Reporting System (URS) Output Tables for Hawaii. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, hawaii, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Region 10, Volume 6

This is a behavioral health report for HHS Region X of the United States and utilizes data from the National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment (N-SSATS), collected annually. The topics addressed in the reports include youth substance use, youth mental health, adult mental health, and substance use treatment.

Tags: behavioral-health, mental-health, samhsa, substance-use, youth-mental-health
Organization: U.S. Department of Health & Human Services
Oklahoma (OK)

This report presents estimates for measures of substance use and mental health based on the combined 2010 and 2011 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for Oklahoma for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: mental-health, oklahoma, samhsa, substance-use, survey-data
Organization: U.S. Department of Health & Human Services
Colorado (CO)

This report presents estimates for measures of substance use and mental health based on the combined 2010 and 2011 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for Colorado for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: colorado-survey, mental-health, nsduh-data, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Publications Using SAMHSA DataNational Mental Health Services Survey (N-MHSS): 2018, Data On Mental Health Treatment Facilities

This report presents findings from the 2018 National Mental Health Services Survey (N-MHSS), an annual census of all known facilities in the United States, both public and private, that provide mental health treatment services to people with mental illness. Planned and directed by the Center for Behavioral Health Statistics and Quality (CBHSQ) of the Substance Abuse and Mental Health Services Administration (SAMHSA), U.S. Department of Health and Human Services, the N-MHSS is designed to collect data on the location, characteristics, and utilization of organized mental health treatment services for facilities within the scope of the survey throughout the 50 states, the District of Columbia, Puerto Rico, and other jurisdictions.

Tags: behavioral-health, mental-health-facilities, mental-health-services, samhsa, treatment-facility-survey
Organization: U.S. Department of Health & Human Services
Acetaminophen poisoning: an update for the intensivist

Acetaminophen overdose is common and can result from deliberate/nonstaggered or accidental/staggered ingestion. Patients presenting within 24 h of an acetaminophen overdose can safely be managed on medical wards. Early management of nonstaggered overdose is guided by the plasma acetaminophen concentration, whereas management of accidental/staggered ingestion is guided by ingested dose. Ingested dose and time from ingestion to presentation are important prognostic factors in accidental/staggered ingestion. Acetaminophen-induced acute liver failure (ALF) requires meticulous supportive care in an intensive care unit (ICU), with early identification and transfer of patients who are likely to require liver transplantation to a specialist liver centre. The modified King's College Hospital criteria (incorporating lactate into the traditional criteria) represent the best tool for identifying patients who require transplantation.

Tags: acetaminophen-toxicity, acute-liver-failure, drug-overdose, kings-college-criteria, nih
Organization: U.S. Department of Health & Human Services
2013 NSDUH Person Pair & Household Weights Report

This report documents the method of weight calibration used for producing the final set of questionnaire dwelling unit (QDU) and pair weights for the National Survey on Drug Use and Health (NSDUH) data from 2013. The weighting team faced several challenges in this task and was able to address them by resorting to innovative modifications of certain basic statistical ideas.

Tags: nsduh-data, samhsa, statistical-calibration, survey-weights, weighting-methodology
Organization: U.S. Department of Health & Human Services
Oxygen-regulated transcription factors and their role in pulmonary disease

The transcription factors nuclear factor interleukin-6 (NF-IL6), early growth response-1 (EGR-1) and hypoxia-inducible factor-1 (HIF-1) have important roles in the molecular pathophysiology of hypoxia-associated pulmonary disease. NF-IL6 controls the production of interleukin (IL)-6 in vascular endothelial cells, which may have anti-inflammatory activity by counteracting effects of IL-1 and IL-8. EGR-1 controls the production of tissue factor by macrophages, which triggers fibrin deposition in the pulmonary vasculature. HIF-1 activates the expression of the vasoconstrictor endothelin-1 in vascular endothelial cells. Angiotensin II induces HIF-1 expression and hypertrophy of pulmonary arterial smooth muscle cells. HIF-1 might therefore have multiple roles in the pathogenesis of pulmonary vascular remodeling.

Tags: hypoxia, nih, pulmonary-disease, transcription-factors, vascular-remodeling
Organization: U.S. Department of Health & Human Services
2017 Uniform Reporting System (URS) Table for Massachusetts

This is the 2017 Uniform Reporting System (URS) Output Tables for Massachusetts. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-program, mental-health-services, national-outcome-measures, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
Binding of protegrin-1 to

Background
          Pseudomonas aeruginosa and Burkholderia cepacia infections of cystic fibrosis patients' lungs are often resistant to conventional antibiotic therapy. Protegrins are antimicrobial peptides with potent activity against many bacteria, including P. aeruginosa. The present study evaluates the correlation between protegrin-1 (PG-1) sensitivity/resistance and protegrin binding in P. aeruginosa and B. cepacia.
        
        
          Methods
          The PG-1 sensitivity/resistance and PG-1 binding properties of P. aeruginosa and B. cepacia were assessed using radial diffusion assays, radioiodinated PG-1, and surface plasmon resonance (BiaCore).
        
        
          Results
          The six P. aeruginosa strains examined were very sensitive to PG-1, exhibiting minimal active concentrations from 0.0625–0.5 μg/ml in radial diffusion assays. In contrast, all five B. cepacia strains examined were greater than 10-fold to 100-fold more resistant, with minimal active concentrations ranging from 6–10 μg/ml. When incubated with a radioiodinated variant of PG-1, a sensitive P. aeruginosa strain bound considerably more protegrin molecules per cell than a resistant B. cepacia strain. Binding/diffusion and surface plasmon resonance assays revealed that isolated lipopolysaccharide (LPS) and lipid A from the sensitive P. aeruginosa strains bound PG-1 more effectively than LPS and lipid A from resistant B. cepacia strains.
        
        
          Conclusion
          These findings support the hypothesis that the relative resistance of B. cepacia to protegrin is due to a reduced number of PG-1 binding sites on the lipid A moiety of its LPS.

Tags: antimicrobial-peptides, burkholderia-cepacia, nih, protegrin-1, pseudomonas-aeruginosa
Organization: U.S. Department of Health & Human Services