AndreaBozzo/ceres-open-data-index huggingface dataset:
States Categorized into Five Groups from Lowest to Highest Estimate, by Age Group: Percentages, Annual Averages Based on 2019 and 2020 NSDUHs

State estimates for these years are no longer available due to methodological concerns with combining 2019 and 2020 data. We apologize for any inconvenience or confusion this may causeBecause of the COVID-19 pandemic, most respondents answered the survey via the web in Quarter 4 of 2020, even though all responses in Quarter 1 were from in-person interviews. It is known that people may respond to the survey differently while taking it online, thus introducing what is called a mode effect.When the state estimates were released, it was assumed that the mode effect was similar for different groups of people. However, later analyses have shown that this assumption should not be made. Because of these analyses, along with concerns about the rapid societal changes in 2020, it was determined that averages across the two years could be misleading.For more detail on this decision, see the 2019-2020state data page.

Tags: mental-health, nsduh-data, samhsa, substance-use, survey-data
Organization: U.S. Department of Health & Human Services
Ensuring competency in end-of-life care: controlling symptoms

Background
          Palliative medicine is assuming an increasingly important role in patient care. The Education for Physicians in End-of-life Care (EPEC) Project is an ambitious program to increase core palliative care skills for all physicians. It is not intended to transmit specialty level competencies in palliative care.
        
        
          Method
          The EPEC Curriculum was developed to be a comprehensive syllabus including trainer notes, multiple approaches to teaching the material, slides, and videos of clinical encounters to trigger discussion are provided. The content was developed through a combination of expert opinion, participant feedback and selected literature review. Content development was guided by the goal of teaching core competencies not included in the training of generalist and non-palliative medicine specialist physicians.
        
        
          Results
          Whole patient assessment forms the basis for good symptom control. Approaches to the medical management of pain, depression, anxiety, breathlessness (dyspnea), nausea/vomiting, constipation, fatigue/weakness and the symptoms common during the last hours of life are described.
        
        
          Conclusion
          While some physicians will have specialist palliative care services upon which to call, most in the world will need to provide the initial approaches to symptom control at the end-of-life.

Tags: end-of-life-care, nih, palliative-medicine, physician-education, symptom-management
Organization: U.S. Department of Health & Human Services
Compound 525271: N'-(3-methoxy-phenyl)-N,N-dimethyl-acetamidine

Chemical compound data from PubChem database. IUPAC Name: N'-(3-methoxyphenyl)-N,N-dimethylethanimidamide. Molecular Formula: C11H16N2O. Molecular Weight: 192.26. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Sample Size and Population Estimates Tables (Standard Errors and P Values) - 3.1 to 3.8

These detailed tables show standard errors of sample sizes and population estimates pertaining to mental health from the 2011 National Survey on Drug Use and Health (NSDUH). Samples sizes and population estimates are provided by age group, gender, race/ethnicity, education level, employment status, poverty level, geographic area, insurance status.

Tags: mental-health, nsduh-2011, population-estimates, samhsa, standard-errors
Organization: U.S. Department of Health & Human Services
2014 CMHS Uniform Reporting System (URS) Table for New Jersey

2014 Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for new Jersey. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-program, community-mental-health, mental-health-services, noms-measures, samhsa
Organization: U.S. Department of Health & Human Services
2013 CMHS Uniform Reporting System (URS) Tables for District of Columbia

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Tables for Districtg of Columbia for 2013. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program.  State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, national-outcome-measures, samhsa, urs-data
Organization: U.S. Department of Health & Human Services
Publications Using SAMHSA Data2019 Uniform Reporting System (URS) Table for Delaware

These are the 2019 Uniform Reporting System (URS) Output Tables for Delaware. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: delaware-mental-health, mental-health-services, national-outcome-measures, samhsa, urs-data
Organization: U.S. Department of Health & Human Services
Publications Using SAMHSA DataTable 8. 2011-2012 NSDUH Nonmedical Use of Pain Relievers in the Past Year, by Age Group and State

Table 8. Nonmedical Use of Pain Relievers in the Past Year, by Age Group and State: Percentages, Annual Averages Based on 2011 and 2012 NSDUHs. Results are provided by State and for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: age-groups, nsduh-data, pain-reliever-misuse, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Phoenix: Drug-Related Emergency Department Visits, 2004-2011 - Illicits (excluding alcohol)

Excel file with estimates, rates, relative standard errors, trends and confidence intervals for all drug-related emergency department (ED) visits involving illicit drugs for the Phoenix metropolitan area, covering 2004-2011. These visits involve the use of drugs that have limited or no therapeutic value and are generally illegal if taken without a prescription. It also includes visits involving the inhalation of substances for their psychoactive properties (e.g., sniffing model airplane glue).

Tags: drug-related-ed, emergency-department-visits, illicit-drug-use, phoenix-metro-area, samhsa
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Oklahoma, 2014

This is a behavioral health report for the state of Oklahoma. It uses the  National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment Services (NSSATS) to address the topics of youth substance use , youth mental health and treatment, adult mental health and treatment, substance use, substance use treatment, and medicare enrollees for the years 2009 to 2013.

Tags: mental-health-services, oklahoma-behavioral-health, samhsa, substance-use-trends, youth-mental-health
Organization: U.S. Department of Health & Human Services
To what degree does cognitive impairment in Alzheimer's disease predict dependence of patients on caregivers?

Background
          Patients with Alzheimer's disease experience a progressive loss of cognitive function, and the ability to independently perform activities of daily life. Sometimes a dependent stage is reached quite early in the disease, when caregivers decide that the patients can no longer be left alone safely. This is an important aspect of Alzheimer's for patients, their families, and also health care providers. Understanding the relationship between a patient's current cognitive status and their need for care may assist clinicians when recommending an appropriate management plan. In this study, we investigated the relationship of cognitive function to dependence on caregivers before the patients reach a severe stage of the disease.
        
        
          Methods
          Data were obtained on 1,289 patients with mild-to-moderate Alzheimer's disease studied in two randomised clinical trials of galantamine (Reminyl®). Cognition was assessed using the cognitive part of the Alzheimer's Disease Assessment Scale (ADAS-cog) and Mini-Mental State Examination (MMSE). Patients were considered dependent if they required >12 hours of supervision each day or had high care needs. The Disability Assessment for Dementia (DAD) scale was also used as a measure of dependence. Disability was predicted directly using MMSE and ADAS-cog and compared to predictions from converted scores.
        
        
          Results
          The odds ratio of dependence was significantly higher amongst the patients with worse cognitive impairment, adjusting for age, gender and antipsychotic medication use. For example, a 4-point difference in ADAS-cog score was associated with an increase of 17% (95% CI 11–23) in the adjusted odds for >12 hours of supervision, and of 35% (95% CI 28–43) for dependence. Disability predicted directly using actual ADAS-cog and scores converted from MMSE values had close agreement using the models developed.
        
        
          Conclusion
          In patients with mild-to-moderate Alzheimer's disease, even relatively small degrees of poorer cognitive function increased the risk of losing the ability to live independently.

Tags: alzheimers-disease, caregiver-dependence, cognitive-impairment, galantamine-trial, nih
Organization: U.S. Department of Health & Human Services
Pennsylvania (PA)

This report presents estimates for measures of substance use and mental health based on the combined 2010 and 2011 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for Pennsylvania for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: mental-health, nsduh-data, pennsylvania, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
The GOLD domain, a novel protein module involved in Golgi function and secretion

Background
          Members of the p24 (p24/gp25L/emp24/Erp) family of proteins have been shown to be critical components of the coated vesicles that are involved in the transportation of cargo molecules from the endoplasmic reticulum to the Golgi complex. The p24 proteins form hetero-oligomeric complexes and are believed to function as receptors for specific secretory cargo.
        
        
          Results
          Using sensitive sequence-profile analysis methods, we identified a novel β-strand-rich domain, the GOLD (Golgi dynamics) domain, in the p24 proteins and several other proteins with roles in Golgi dynamics and secretion. This domain is predicted to mediate diverse protein-protein interactions. Other than in the p24 proteins, the GOLD domain is always found combined with lipid- or membrane-association domains such as the pleckstrin homology (PH), Sec14p and FYVE domains.
        
        
          Conclusions
          The identification of the GOLD domain could aid in directed investigation of the role of the p24 proteins in the secretion process. The newly detected group of GOLD-domain proteins, which might simultaneously bind membranes and other proteins, point to the existence of a novel class of adaptors that could have a role in the assembly of membrane-associated complexes or in regulating assembly of cargo into membranous vesicles.

Tags: golgi-complex, nih, p24-proteins, protein-domains, protein-secretion
Organization: U.S. Department of Health & Human Services
Impact of renal dysfunction on weaning from prolonged mechanical ventilation

Background:
          In the intensive care unit (ICU) setting, the combination of mechanical ventilation and renal replacement therapy (RRT) has been associated with prolonged length of hospital stay, high cost of care and poor outcome. We gathered outcome data on patients who had severe renal dysfunction on transfer to our regional weaning center (RWC) for attempted weaning from prolonged mechanical ventilation (PMV). We screened the admission laboratory values of 1077 patients transferred to our RWC over an 8-year period. We reviewed the medical records of patients with serum creatinine > 2.5 mg/dl.
        
        
          Results:
          Sixty-three patients met screening criteria and 40 patients were on RRT at the time of transfer. Eighteen patients had begun chronic RRT at least 2 months prior to admission to the transferring hospital for their current illness. Twenty-two patients had RRT initiated at the transferring hospital. Ten patients had RRT initiated at the RWC; eight patients had improvement or resolution of azotemia at our facility. RRT was withheld at patient/family request in five patients with progressive renal failure. None of the 50 patients who received RRT recovered renal function during treatment at our RWC. Intermittent hemodialysis was the standard RRT at the RWC. Duration of mechanical ventilation prior to transfer to the RWC was 49.7 ± 33.5 days (mean ± SD).
          Outcome of weaning attempts in the 63 patients was as follows: 13% weaned, 3% failed to wean and 84% died. These outcomes were significantly worse (P<0.001) than those in the 1014 patients whose admission serum creatinine was ≤ 2.5 mg/dl (58% weaned, 15% failed to wean, 27% died). The five patients in whom RRT was withheld were predominantly in progressive multisystem organ failure, and were unlikely to have survived regardless of RRT. From the study cohort, only one of the 10 patients discharged alive returned home, in contrast to 42% of the control group. No patient with severe renal dysfunction survived to 1 year post-discharge, compared to a 1-year survival of 38% in the control group (P = 0.029). Only four of the 10 patients survived more than 1 month, with the longest survival being 122 days.
        
        
          Conclusions:
          Patients who require PMV and RRT have a very poor prognosis. The small number of patients with renal insufficiency not requiring RRT had a more favorable hospital outcome and mortality, but long-term survival remained poor.

Tags: mechanical-ventilation, nih, renal-dysfunction, renal-replacement, ventilator-weaning
Organization: U.S. Department of Health & Human Services
2013 CMHS Uniform Reporting System (URS) Table for Wisconsin

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Tables for Wisconsin for 2013. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program.  State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, noms-measures, samhsa, urs-data
Organization: U.S. Department of Health & Human Services
Compound 525416: 2-Methyl-4-ethyl-3,5-dithiahexane

Chemical compound data from PubChem database. IUPAC Name: 1-methylsulfanyl-1-propan-2-ylsulfanylpropane. Molecular Formula: C7H16S2. Molecular Weight: 164.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Alabama (AL)

This report uses 2008 to 2010 National Survey on Drug Use and Health (NSDUH) to assess past year alcohol use disorder and illicit drug use disorder among persons aged 12 or older for Alabama overall and for substate regions within Alabama. Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE).

Tags: alcohol-abuse, mental-health-alabama, nsduh-data, samhsa, substance-use-disorder
Organization: U.S. Department of Health & Human Services
2016 National Survey on Drug Use and Health:  Methodological Summary and Definitions

This report summarizes methods and other supporting information that are relevant to estimates of substance use and mental health issues from the 2016 National Survey on Drug Use and Health (NSDUH), an annual survey of the civilian, noninstitutionalized population of the United States aged 12 years old or older. NSDUH is the primary source of statistical information on the use of tobacco, alcohol, prescription psychotherapeutic drugs (pain relievers, tranquilizers, stimulants, and sedatives), and other substances (e.g., marijuana, cocaine) by the U.S. civilian, noninstitutionalized population aged 12 or older. The survey also includes several series of questions that focus on mental health issues.

Tags: behavioral-health, mental-health, nsduh-survey, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Compound 528478: 4,7-Dimethyldecane

Chemical compound data from PubChem database. IUPAC Name: 4,7-dimethyldecane. Molecular Formula: C12H26. Molecular Weight: 170.33. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
A ~35 kDa polypeptide from insect cells binds to yeast ACS like elements in the presence of ATP

Background
          The S. cerevisiae origin recognition complex binds to the ARS consensus sequence in an ATP dependent fashion. Recently, the yeast Cdc6 has been reported to have DNA binding activity. Conservation of replication proteins among different species strongly supports their functional similarity. Here we report the results of an investigation into the DNA binding activity of human Cdc6 protein. Cdc6 was expressed and purified from baculovirus infected Sf9 (Spodoptera frugiperda) insect cells as GST fusion protein (GST-Cdc6) and its DNA binding activity was tested.
        
        
          Results
          Partially purified fractions containing GSTCdc6 or GST showed an ACS binding activity in an ATP dependent manner. However, further purification revealed the presence of a putative 35 kDa insect cell protein (p35) which was found responsible for the DNA binding activity. A close match to the 9/11 bases of the ARS consensus sequence was sufficient for p35 binding activity. A DNA fragment from the human c-myc origin region containing yeast ACS like elements also showed p35 binding activity.
        
        
          Conclusions
          We have identified a Spodoptera frugiperda protein with ATP dependent DNA binding activity to ACS like elements. ACS like elements have been reported to be essential for ORC binding and replication initiation in yeast but their role in higher eukaryotes still remains elusive. Like the ARS consensus sequence elements of yeast, ACS like elements found in c-myc and lamin beta 2 origin regions may play similar roles in replication and indicate a conserved role for this DNA motif among eukaryotes.

Tags: cdc6-protein, dna-binding, insect-cells, nih, replication-proteins
Organization: U.S. Department of Health & Human Services
States Categorized into Five Groups from Lowest to Highest Estimate, by Age Group: Percentages, Annual Averages Based on 2017 and 2018 NSDUHs

States Categorized into Five Groups from Lowest to Highest Estimate, by Age Group: Percentages, Annual Averages Based on 2017 and 2018 NSDUHs

Tags: mental-health, nsduh, samhsa, state-estimates, substance-use
Organization: U.S. Department of Health & Human Services
2016 Uniform Reporting System (URS) Table for Illinois

This is the 2016 Uniform Reporting System (URS) Output Tables for Illinois. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant, illinois, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
2017 NSDUH Annual National Report

This report summarizes key findings from the 2017 National Survey on Drug Use and Health (NSDUH) for national indicators of substance use and mental health among people aged 12 years old or older in the civilian, noninstitutionalized population of the United States.

Tags: drug-use, mental-health, national-survey, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Compound 525210: 5-Chloroheptanoic acid, chloromethyl ester

Chemical compound data from PubChem database. IUPAC Name: chloromethyl 5-chloroheptanoate. Molecular Formula: C8H14Cl2O2. Molecular Weight: 213.1. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
4.7 Facility capacity and utilization of hospital inpatient care, by facility operation and primary focus of facility: March 31, 2011. Number, utilization rate, and percent distribution

This a National Survey of Substance Abuse Treatment Services (N-SSATS) data table showing facility capacity and utilization of hospital inpatient care, by facility operation and primary focus of facility in 2011.

Tags: facility-capacity, hospital-beds, inpatient-care-utilization, samhsa, substance-abuse-treatment
Organization: U.S. Department of Health & Human Services
The DAWN Report: Emergency Department Visits Involving Phencyclidine

This Drug Abuse Warning Network (DAWN) short report shows the estimated number of emergency department visits involving phencyclidine (PCP) between 2005 and 2011. The report specifically talks about age groups, gender and other drugs such as marijuana, cocaine, heroin and pharmaceuticals and trends over time.

Tags: drug-related-visits, emergency-department, pcp-abuse, samhsa, substance-abuse-trends
Organization: U.S. Department of Health & Human Services
2013 CMHS Uniform Reporting System (URS) Tables for American Samoa

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Tables for American Somoa for 2013. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program.  State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: american-samoa, block-grant-data, mental-health-services, noms-measures, samhsa
Organization: U.S. Department of Health & Human Services