AndreaBozzo/ceres-open-data-index huggingface dataset:
Transcutaneous flow related variables measured in vivo: the effects of gender

Backgound
          The identification of potential sources of error is a crucial step for any new assessment technique. This is the case for transcutaneous variables, such as flow and arterial gases, which have been applied as functional indicators of various aspects of human health. Regarding gender, a particular subject-related determinant, it is often claimed that women present higher transcutaneous oxygen pressure (tcpO2) values than men. However, the statistical significance of this finding is still uncertain.
        
        
          Methods
          The haemodynamical-vascular response to a local reactive hyperaemia procedure (the tourniquet cuff manoeuvre) was studied in two previously selected group of volunteers (n = 16; 8 women and 8 men). The effect of gender was assessed under standardised experimental conditions, using the transcutaneous flow-related variables tcpO2-tcpCO2 and Laser-doppler Flowmetry (LDF).
        
        
          Results
          Regarding tcpO2, statistically significant differences between genders were not found, although higher values were consistently found for the gases in the female group. Regarding LDF, high statistically significant differences (p < 0.005) were found, with the men's group presenting the highest values and variability. Other derived parameters used to characterise the vascular response following the cuff-deflation (t-peak) were similar in both groups.
        
        
          Conclusions
          The relative influence of gender was not clearly demonstrated using these experimental conditions. However the gender-related LDF differences suggest that further investigation should be done on this issue. Perhaps in the presence of certain pathological disparities involving peripheral vascular regulation, other relationships may be found between these variables.

Tags: gender-differences, laser-doppler-flowmetry, nih, reactive-hyperaemia, transcutaneous-oxygen
Organization: U.S. Department of Health & Human Services
Drug Abuse Warning Network, 2010: Methodology Report

This publication describes the methodologies used by the Drug Abuse Warning Network (DAWN), to collect, prepare, and analyze information on drug-related emergency department (ED) visits in the United States. The methods described here were initiated in 2004 and are current as of 2010.

Tags: data-collection, drug-abuse, emergency-department, methodology, samhsa
Organization: U.S. Department of Health & Human Services
2013 CMHS Uniform Reporting System (URS) Tables for Idaho

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Tables for Idaho for 2013. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program.  State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, national-outcome-measures, samhsa, urs-data
Organization: U.S. Department of Health & Human Services
2012-2013 NSDUH National Maps of State Estimates

National maps presented here show estimates from the 2012-2013 National Surveys on Drug Use and Health (NSDUH) for 25 substance use and mental health outcomes, by age group, for 50 States and the District of Columbia. The color of each State indicates how a State ranks relative to other States for each measure.  States with the highest rates for a given measure are in red, with the exception of the perceptions of great risk measures, for which the lowest perceptions of great risk are in red. Those States with the lowest estimates are in white, with the exception of the perceptions of great risk measures, for which the highest perceptions of great risk are in white.

Tags: mental-health, nsduh-data, samhsa, state-estimates, substance-use
Organization: U.S. Department of Health & Human Services
National Mental Health Services Survey (N-MHSS): 2014, Data on Mental Health Treatment Facilities

This is an annual report that presents findings from the 2014 National Mental Health Services Survey (N-MHSS) conducted from April 2014 through January 2015. The N-MHSS collects information from all known facilities in the United States, both public and private, that provide mental health treatment services to people with mental illness. The N-MHSS is designed to collect data on the location, characteristics, and utilization of organized mental health treatment service providers throughout the 50 states, the District of Columbia, and the U.S. territories.

Tags: facility-survey, mental-health-services, mental-illness, samhsa, treatment-facilities
Organization: U.S. Department of Health & Human Services
Helium oxygen mixtures in the intensive care unit

Heliox, a mixture of helium and oxygen, has a density that is less than that of air. Breathing heliox leads to a reduction in resistance to flow within the airways, and consequently to a decrease in the work of breathing (WOB), particularly in disorders that are characterized by increased airways resistance. Beneficial effects have been observed in patients with asthma, chronic obstructive pulmonary disease (COPD), bronchiolitis, bronchopulmonary dysplasia and upper airways obstruction. Until we have conclusive data that attest to the efficacy of heliox in such conditions, its use will remain controversial. Meanwhile, it appears wise not to incorporate heliox therapy into routine practice because of technical complications and high costs.

Tags: heliox-therapy, intensive-care, mechanical-ventilation, nih, respiratory-distress
Organization: U.S. Department of Health & Human Services
Compound 525240: N''-(3-fluoro-phenyl)-N,N,N',N'-tetramethyl-guanidine

Chemical compound data from PubChem database. IUPAC Name: 2-(3-fluorophenyl)-1,1,3,3-tetramethylguanidine. Molecular Formula: C11H16FN3. Molecular Weight: 209.26. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 525471: 4,6-Dithia-1-heptene

Chemical compound data from PubChem database. IUPAC Name: 3-(methylsulfanylmethylsulfanyl)prop-1-ene. Molecular Formula: C5H10S2. Molecular Weight: 134.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Self-medication and non-doctor prescription practices in Pokhara valley, Western Nepal: a questionnaire-based study

Background
          Self-medication and non-doctor prescribing of drugs is common in developing countries. Complementary and alternative medications, especially herbs, are also commonly used. There are few studies on the use of these medications in Pokhara Valley, Western Nepal.
        
        
          Methods
          Previously briefed seventh semester medical students, using a semi-structured questionnaire, carried out the study on 142 respondents. Demographic information and information on drugs used for self-medication or prescribed by a non-allopathic doctor were collected.
        
        
          Results
          Seventy-six respondents (54%) were aged between 20 to 39 years. The majority of the respondents (72 %) stayed within 30 minutes walking distance of a health post/medical store. 59% of these respondents had taken some form of self-medication in the 6-month period preceding the study. The common reasons given for self-medication were mild illness, previous experience of treating a similar illness, and non-availability of health personnel. 70% of respondents were prescribed allopathic drugs by a non-allopathic doctor. The compounder and health assistant were common sources of medicines. Paracetamol and antimicrobials were the drugs most commonly prescribed. A significantly higher proportion of young (<40 years) male respondents had used self-medication than other groups.
        
        
          Conclusions
          Self-medication and non-doctor prescribing are common in the Pokhara valley. In addition to allopathic drugs, herbal remedies were also commonly used for self-medication. Drugs, especially antimicrobials, were not taken for the proper duration. Education to help patients decide on the appropriateness of self-medication is required.

Tags: nepal-health, nih, prescription-practices, questionnaire-study, self-medication
Organization: U.S. Department of Health & Human Services
2015 CMHS Uniform Reporting System (URS) Table for North Carolina

2015 Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for North Carolina.  The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-data, mental-health-services, noms-measures, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
Evaluating Prevention Services in Child Welfare

This report describes common types of child maltreatment prevention services, provides an overview of conceptual frameworks relevant to maltreatment prevention programs, and discusses common challenges to evaluating maltreatment prevention services and recommended strategies for addressing them.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: child, maltreatment, policy, prevention, reporting
Organization: U.S. Department of Health & Human Services
Compound 528582: Propanedioic acid, bis(tert-butyldimethylsilyl) ester

Chemical compound data from PubChem database. IUPAC Name: bis[tert-butyl(dimethyl)silyl] propanedioate. Molecular Formula: C15H32O4Si2. Molecular Weight: 332.58. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2017-2018 National Survey on Drug Use and Health: Guide to State Tables and Summary of Small Area Estimation Methodology

This document provides information on the model-based small area estimates of substance use and mental disorders in states based on data from the combined 2017-2018 National Surveys on Drug Use and Health (NSDUHs).

Tags: mental-disorders, nsduh, samhsa, small-area-estimation, substance-use
Organization: U.S. Department of Health & Human Services
Comparison of NSDUH Mental Health Data and Methods with Other Data Sources

This report compares estimates of adult mental health from the 2009 National Survey on Drug Use and Health (NSDUH) with estimates of similar measures from 2001 to 2003 National Comorbidity Survey Replication (NCS-R), 2001 to 2002 National Epidemiologic Survey on Alcohol and Related Conditions (NESARC), 2007 Behavioral Risk Factor Surveillance System (BRFSS), 2008 National Health Interview Survey (NHIS), 2008 Medical Expenditure Panel Survey (MEPS), and 2008 Uniform Reporting System (URS).

Tags: adult-mental-health, mental-health-estimates, mental-health-surveillance, samhsa, survey-comparison
Organization: U.S. Department of Health & Human Services
Evolution of gene fusions: horizontal transfer versus independent events

Background
          Gene fusions can be used as tools for functional prediction and also as evolutionary markers. Fused genes often show a scattered phyletic distribution, which suggests a role for processes other than vertical inheritance in their evolution.
        
        
          Results
          The evolutionary history of gene fusions was studied by phylogenetic analysis of the domains in the fused proteins and the orthologous domains that form stand-alone proteins. Clustering of fusion components from phylogenetically distant species was construed as evidence of dissemination of the fused genes by horizontal transfer. Of the 51 examined gene fusions that are represented in at least two of the three primary kingdoms (Bacteria, Archaea and Eukaryota), 31 were most probably disseminated by cross-kingdom horizontal gene transfer, whereas 14 appeared to have evolved independently in different kingdoms and two were probably inherited from the common ancestor of modern life forms. On many occasions, the evolutionary scenario also involves one or more secondary fissions of the fusion gene. For approximately half of the fusions, stand-alone forms of the fusion components are encoded by juxtaposed genes, which are known or predicted to belong to the same operon in some of the prokaryotic genomes. This indicates that evolution of gene fusions often, if not always, involves an intermediate stage, during which the future fusion components exist as juxtaposed and co-regulated, but still distinct, genes within operons.
        
        
          Conclusion
          These findings suggest a major role for horizontal transfer of gene fusions in the evolution of protein-domain architectures, but also indicate that independent fusions of the same pair of domains in distant species is not uncommon, which suggests positive selection for the multidomain architectures.

Tags: gene-fusion, horizontal-gene-transfer, nih, phylogenetic-analysis, protein-domains
Organization: U.S. Department of Health & Human Services
Publications Using SAMHSA Data2023 Uniform Reporting System (URS) Table For Washington

This is the 2023 Uniform Reporting System (URS) Output Tables for Washington. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: behavioral-health, mental-health-services, national-outcome-measures, samhsa, urs-data
Organization: U.S. Department of Health & Human Services
2022 National Substance Use and Mental Health Services Survey (N-SUMHSS) Detailed Tables

The Annual Detailed Tables present in-depth findings on location, characteristics, and utilization of substance use and mental health services as collected by the National Substance Use and Mental Health Survey (N-SUMHSS). The data presented are intended to provide behavioral health services providers; researchers; and federal, state, and local governments with information about the number and characteristics of public and private substance use and mental health treatment facilities nationwide.

Tags: behavioral-health, mental-health-services, samhsa, substance-use-treatment, treatment-facility-data
Organization: U.S. Department of Health & Human Services
Table 2. Marijuana Use in the Past Year, by Age Group and State: Percentages, Annual Averages Based on 2011 and 2012 NSDUHs

Table 2. Marijuana Use in the Past Year, by Age Group and State: Percentages, Annual Averages Based on 2011 and 2012 NSDUHs

Tags: marijuana-use, nsduh-data, samhsa, state-level-data, substance-use
Organization: U.S. Department of Health & Human Services
A study of quality measures for protein threading models

Background
          Prediction of protein structures is one of the fundamental challenges in biology today. To fully understand how well different prediction methods perform, it is necessary to use measures that evaluate their performance. Every two years, starting in 1994, the CASP (Critical Assessment of protein Structure Prediction) process has been organized to evaluate the ability of different predictors to blindly predict the structure of proteins. To capture different features of the models, several measures have been developed during the CASP processes. However, these measures have not been examined in detail before. In an attempt to develop fully automatic measures that can be used in CASP, as well as in other type of benchmarking experiments, we have compared twenty-one measures. These measures include the measures used in CASP3 and CASP2 as well as have measures introduced later. We have studied their ability to distinguish between the better and worse models submitted to CASP3 and the correlation between them.
        
        
          Results
          Using a small set of 1340 models for 23 different targets we show that most methods correlate with each other. Most pairs of measures show a correlation coefficient of about 0.5. The correlation is slightly higher for measures of similar types. We found that a significant problem when developing automatic measures is how to deal with proteins of different length. Also the comparisons between different measures is complicated as many measures are dependent on the size of the target. We show that the manual assessment can be reproduced to about 70% using automatic measures. Alignment independent measures, detects slightly more of the models with the correct fold, while alignment dependent measures agree better when selecting the best models for each target. Finally we show that using automatic measures would, to a large extent, reproduce the assessors ranking of the predictors at CASP3.
        
        
          Conclusions
          We show that given a sufficient number of targets the manual and automatic measures would have given almost identical results at CASP3. If the intent is to reproduce the type of scoring done by the manual assessor in in CASP3, the best approach might be to use a combination of alignment independent and alignment dependent measures, as used in several recent studies.

Tags: casp-assessment, nih, protein-structure, quality-measures, threading-models
Organization: U.S. Department of Health & Human Services
Sixth International Workshop on Scleroderma Research, Oxford, UK, 30 July–2 August 2000

We discuss major topics presented at this recent international workshop, illustrating how recent progress in areas as diverse as free radical biochemistry, developmental biology, molecular genetics and vascular biology is facilitating greater understanding of the multisystem connective tissue disease scleroderma. Some of the opportunities for translating this into novel and improved therapy are considered.

Tags: connective-tissue-disease, nih, scleroderma-research, scleroderma-therapy, vascular-biology
Organization: U.S. Department of Health & Human Services
Knowledge and perception about stroke among an Australian urban population

Background
          The aim of the study was to measure knowledge about the symptoms, prevalence and natural history of stroke; the level of concern about having a stroke; understanding of the possibilities for preventing stroke, and the relationship between age, sex, country of origin, educational level, income, self-reported risk factors, and the above factors.
        
        
          Methods
          A random sample of households was selected from an electronic telephone directory in Newcastle and Lake Macquarie area of New South Wales, Australia, between 10 September and 13 October 1999. Within each household the person who was between 18 and 80 years of age and who had the next birthday was eligible to participate in the study (1325 households were eligible). The response rate was 62%.
        
        
          Results
          The most common symptoms of stroke listed by respondents were "Sudden difficulty of speaking, understanding or reading" identified by 60.1% of the respondents, and "paralysis on one side of body" identified by 42.0% of the respondents. The level of knowledge of the prevalence of a stroke, full recovery after the stroke, and death from stroke was low and generally overestimated. 69.9% of the respondents considered strokes as being either moderately or totally preventable. There were few predictors of knowledge.
        
        
          Conclusion
          The study suggests that educational strategies may be required to improve knowledge about a wide range of issues concerning stroke in the community, as a prelude to developing preventive programmes.

Tags: australian-population, nih, stroke-knowledge, stroke-perception, stroke-symptoms
Organization: U.S. Department of Health & Human Services
Traumatic brain injury as a risk factor for Alzheimer disease. Comparison of two retrospective autopsy cohorts with evaluation of ApoE genotype

Background and Purpose
          The impact of traumatic brain injury (TBI) on the pathogenesis of Alzheimer disease (AD) is still controversial. The aim of our retrospective autopsy study was to assess the impact of TBE and ApoE allele frequency on the development of AD.
        
        
          Material and Methods
          We examined 1. the incidence of AD pathology (Braak stageing, CERAD, NIA-Reagan Institute criteria) in 58 consecutive patients (mean age ± SD 77.0 ± 6.8 years) with residual closed TBI lesions, and 2. the frequency of TBI residuals in 57 age-matched autopsy proven AD cases. In both series, ApoE was evaluated from archival paraffin-embedded brain material.
        
        
          Results
          1. TBE series: 12.1 % showed definite and 10.3% probable AD (mean age 77.6 and 75.2 years), only 2/13 with ApoEε3/4. From 45 (77.6%) non-AD cases (mean age 78.2 years), 3 had ApoEε3/4. The prevalence of 22.4% AD in this small autopsy cohort was significantly higher than 3.3% in a recent large clinical series and 14% in the general population over age 70. 2. In the AD cohort with ApoEε4 allele frequency of 30% similar to other AD series, residuals of closed TBI were seen in 4 brains (7%) (mean age ± SD 78.2 ± 6.4), all lacking the ApoEε4 allele. TBI incidence was slightly lower than 8.5% in the clinical MIRAGE study.
        
        
          Conclusions
          The results of this first retrospective autopsy study of TBI, ApoEε allele frequency, and AD confirm clinical studies suggesting severe TBI to be a risk factor for the development AD higher in subjects lacking ApoEε4 alleles. Further studies in larger autopsy series are needed to elucidate the relationship between TBI, genetic predisposition, and AD.

Tags: alzheimer-disease, apoe-genotype, autopsy-study, nih, traumatic-brain-injury
Organization: U.S. Department of Health & Human Services
2010 CMHS Uniform Reporting System (URS) Output Tables for South Dakota

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2010. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-data, mental-health-services, noms-measures, samhsa, south-dakota
Organization: U.S. Department of Health & Human Services
2010 CMHS Uniform Reporting System (URS) Output Tables for American Samoa

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2010. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: american-samoa, block-grant-data, mental-health-services, noms-measures, samhsa
Organization: U.S. Department of Health & Human Services