AndreaBozzo/ceres-open-data-index huggingface dataset:
Compound 529817: Heptanal, 2,4,6-trichlorophenyl hydrazone

Chemical compound data from PubChem database. IUPAC Name: 2,4,6-trichloro-N-(heptylideneamino)aniline. Molecular Formula: C13H17Cl3N2. Molecular Weight: 307.6. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
The κB transcriptional enhancer motif and signal sequences of V(D)J recombination are targets for the zinc finger protein HIVEP3/KRC: a site selection amplification binding study

Background
          The ZAS family is composed of proteins that regulate transcription via specific gene regulatory elements. The amino-DNA binding domain (ZAS-N) and the carboxyl-DNA binding domain (ZAS-C) of a representative family member, named κB DNA binding and recognition component (KRC), were expressed as fusion proteins and their target DNA sequences were elucidated by site selection amplification binding assays, followed by cloning and DNA sequencing. The fusion proteins-selected DNA sequences were analyzed by the MEME and MAST computer programs to obtain consensus motifs and DNA elements bound by the ZAS domains.
        
        
          Results
          Both fusion proteins selected sequences that were similar to the κB motif or the canonical elements of the V(D)J recombination signal sequences (RSS) from a pool of degenerate oligonucleotides. Specifically, the ZAS-N domain selected sequences similar to the canonical RSS nonamer, while ZAS-C domain selected sequences similar to the canonical RSS heptamer. In addition, both KRC fusion proteins selected oligonucleoties with sequences identical to heptamer and nonamer sequences within endogenous RSS.
        
        
          Conclusions
          The RSS are cis-acting DNA motifs which are essential for V(D)J recombination of antigen receptor genes. Due to its specific binding affinity for RSS and κB-like transcription enhancer motifs, we hypothesize that KRC may be involved in the regulation of V(D)J recombination.

Tags: dna-binding-domains, kb-motif, nih, transcription-regulation, vdj-recombination
Organization: U.S. Department of Health & Human Services
Patent AT-393333-B: [Translated] ION PROJECTION DEVICE FOR SHADOW PROJECTION

An ion-projecting apparatus which has between the ion source and the mask, directly proximal to the mask, at least one ion optical correction element in the form of a multipole with at least eight poles and so located that there is no other deflection means between the octapole and the mask.

Tags: chemistry, innovation, patent, pubchem, research
Organization: U.S. Department of Health & Human Services
Accuracy of prognosis estimates by four palliative care teams: a prospective cohort study

Background
          Prognosis estimates are used to access services, but are often inaccurate. This study aimed to determine the accuracy of giving a prognosis range.
        
        
          Methods and measurements
          A prospective cohort study in four multi-professional palliative care teams in England collected data on 275 consecutive cancer referrals who died. Prognosis estimates (minimum – maximum) at referral, patient characteristics, were recorded by staff, and later compared with actual survival.
        
        
          Results
          Minimum survival estimates ranged <1 to 364 days, maximum 7 – 686 days. Mean patient survival was 71 days (range 1 – 734). In 42% the estimate was accurate, in 36% it was over optimistic and in 22% over pessimistic. When the minimum estimate was less than 14 days accuracy increased to 70%. Accuracy was related, in multivariate analysis, to palliative care team and (of borderline significance) patient age.
        
        
          Conclusions
          Offering a prognosis range has higher levels of accuracy (about double) than traditional estimates, but is still very often inaccurate, except very close to death. Where possible clinicians should discuss scenarios with patients, rather than giving a prognosis range.

Tags: cancer-survival, nih, palliative-care, prognosis-accuracy, survival-estimation
Organization: U.S. Department of Health & Human Services
Gene-expression profile comparisons distinguish seven organs of maize

Relative mRNA levels from maize organs have been quantified by hybridization to maize arrays fabricated with 5,376 unique expressed sequence tag clones. mRNAs from embryos, three vegetative organs (leaf blades, leaf sheaths and roots), husk leaves and two types of floral organs (immature ears and silks) reveal that a majority of genes expressed in diverse organs with little difference in transcript levels.

Tags: gene-expression, maize-organs, mrna-levels, nih, plant-biology
Organization: U.S. Department of Health & Human Services
Tribal Courts and Child Welfare: Being Family Centered

This Child Welfare Information Gateway Podcast is available on Apple Podcasts
  
  

, GooglePlay
  
  

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 website. Subscribe to receive new episodes as they are released.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: child, family, law, policy, social
Organization: U.S. Department of Health & Human Services
Patent AT-E400657-T1: [Translated] METHOD FOR SEPARATING EPOXY-ENANTIMER MIXTURES USING EPOXY HYDROLASE-PRODUCING MICROORGANISMS

A description is given of epoxide hydrolases from bacteria of the genus Streptomyces, a novel process for the enzymatic separation of epoxide enantiomeric mixtures, of a novel detection method for epoxide hydrolase activity, a screening method for detecting epoxide hydrolase activity and the use of bacteria of the genus Streptomyces and of the resultant epoxide hydrolases for enantioselective epoxide hydrolysis.

Tags: chemistry, innovation, patent, pubchem, research
Organization: U.S. Department of Health & Human Services
2012 Uniform Reporting System (URS) Tables for Ohio

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2012. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: behavioral-health, community-mental-health, mental-health-services, outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Compound 525178: Pentaethylene glycol, monoallyl ether, acetate

Chemical compound data from PubChem database. IUPAC Name: 2-[2-[2-[2-(2-prop-2-enoxyethoxy)ethoxy]ethoxy]ethoxy]ethyl acetate. Molecular Formula: C15H28O7. Molecular Weight: 320.38. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 527192: (3S,3aR,6R,8aS)-3,7,7-Trimethyl-8-methylenehexahydro-1H-3a,6-methanoazulen-2(3H)-one

Chemical compound data from PubChem database. IUPAC Name: 2,7,7-trimethyl-6-methylidenetricyclo[6.2.1.01,5]undecan-3-one. Molecular Formula: C15H22O. Molecular Weight: 218.33. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Table 23. Serious Mental Illness in the Past Year, by Age Group and State: Percentages, Annual Averages Based on 2013 and 2014 NSDUHs

Table 23. Serious Mental Illness in the Past Year, by Age Group and State: Percentages, Annual Averages Based on 2013 and 2014 NSDUHs

Tags: adult-mental-health, mental-health-prevalence, nsduh-data, samhsa, serious-mental-illness
Organization: U.S. Department of Health & Human Services
Compound 528406: 2-Methyl-4-propyloxazole

Chemical compound data from PubChem database. IUPAC Name: 2-methyl-4-propyl-1,3-oxazole. Molecular Formula: C7H11NO. Molecular Weight: 125.17. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Aseptic meningitis in Germany associated with echovirus type 13

Background
          Echoviruses are the commonest cause of aseptic meningitis. Echovirus type 13 which has not been isolated in Germany over a long period of time was the predominant enterovirus serotype associated with different local outbreaks of aseptic meningitis in Germany in 2000.
        
        
          Methods
          Virus isolation was performed from cerebrospinal fluid and stools. In order to study the genetic relationship of echovirus type 13 isolates, sequence analysis of a part of VP1 (~300 nt) was carried out. Isolates from different geographic regions were compared to each other as well as to elder viruses (prototype strain from 1953, four isolates from 1965–1986).
        
        
          Results
          Overall, 55 isolates of echovirus type 13 were obtained from different parts of Germany. It was shown that the new isolated strains have a very high degree of homology on the nucleotide level (> 98%)) but differ significantly from the old strains (76–85%).
        
        
          Conclusions
          a) Rare enterovirus serotypes can cause serious illness.
          b) The molecular drift has also been shown for other enterovirus serotypes.

Tags: aseptic-meningitis, echovirus-13, germany, nih, viral-meningitis
Organization: U.S. Department of Health & Human Services
2014 CMHS Uniform Reporting System (URS) Table for Michigan

2014 Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for Michigan. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, national-outcome-measures, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
Patent AT-E399551-T1: [Translated] AIDS AND METHODS FOR THE TRANSDERMAL APPLICATION OF FELODIPINE

A method of effectively treating hypertension in humans is achieved by administering felodipine via a transdermal formulation. Preferably, the transdermal formulation is applied to the skin of the patient and maintained in contact with the skin for at least about 24 hours days, and preferably for about 3 to about 8 days.

Tags: chemistry, innovation, patent, pubchem, research
Organization: U.S. Department of Health & Human Services
Compound 529530: Methyl 3-amino-5-[(2-methoxy-2-oxoethyl)sulfanyl]-4-(trifluoromethyl)-2-thiophenecarboxylate

Chemical compound data from PubChem database. IUPAC Name: 1,6-difluorophenanthrene. Molecular Formula: C14H8F2. Molecular Weight: 214.21. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Patent AT-E400876-T1: [Translated] COMPOSITE COMPONENT FOR FUSION REACTOR

Chemical patent from PubChem database. Patent Number: AT-E400876-T1. Title: Chemical Synthesis Method. Filing Date: 2007-12-23. Inventors: Anderson, Robert, Davis, Linda. Abstract: A novel method for chemical synthesis is provided, utilizing specific catalysts and reaction conditions to achieve selective transformations with high... IPC Classifications: A61K, A61L, A61F. This patent covers 28 claims related to 3 chemical compounds. Useful for intellectual property research, prior art searches, and chemical innovation tracking.

Tags: chemistry, innovation, patent, pubchem, research
Organization: U.S. Department of Health & Human Services
Research Article: BMC Infectious Diseases

Background
          Pyrazinamide (PZA) is among the first-line drugs for the treatment of tuberculosis. In vitro, it kills semidormant mycobacteria only at low pH. The purpose of this study was to compare PZA resistance with pyrazinamidase (PZase) activity and the genotype to better understand the molecular basis of PZA resistance and to expand the profile of pncA mutations worldwide.
        
        
          Results
          Of the 28 tested strains of Mycobacterium tuberculosis, 6 were susceptible to PZA and positive for PZase activity and had no pncA mutations. Twenty-one strains were resistant to PZA and negative for PZase activity and had mutations in the pncA gene, including 15 point mutations, 5 insertions, and 2 deletions. One strain had no mutation in the pncA gene, even though it was resistant to PZA and negative for PZase activity. Three isolates had adenine to guanine point mutations in the -11 upstream region, making this the most common type of pncA mutations in this study, with at least two different RFLP patterns.
        
        
          Conclusion
          These data help in the understanding of the molecular basis of PZA resistance. An adenine to guanine point mutation in the -11 upstream region was the most common type of pncA mutation in our isolates. The results of pncA mutation analyses should be carefully interpreted for epidemiologic purposes.

Tags: mycobacterium-tuberculosis, nih, pnca-mutations, pyrazinamide-resistance, tuberculosis-treatment
Organization: U.S. Department of Health & Human Services
Patent AT-E400855-T1: [Translated] SYSTEM AND METHOD FOR SECURE DATA STREAMING USING A VIRTUAL CHIP CARD

There is disclosed a process for encrypting a data stream to secure the data stream for single viewing and to protect copyrights of the data stream. Specifically, there is disclosed a process for protecting streaming multimedia, entertainment and communications in an Internet-type transmission. There is further disclosed a streaming server component operably connected with a streaming server that interacts with a client system that includes a virtual smart card to effect the inventive process.

Tags: chemistry, innovation, patent, pubchem, research
Organization: U.S. Department of Health & Human Services
District of Columbia (DC)

This report presents estimates for measures of substance use and mental health based on the combined 2010 and 2011 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for District of Columbia for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: dc-health, mental-health, nsduh-data, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
2022 Uniform Reporting System (URS) Table For Illinois

This is the 2022 Uniform Reporting System (URS) Output Tables for Illinois. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant, illinois, mental-health-services, noms-measures, samhsa
Organization: U.S. Department of Health & Human Services
Compound 529213: Cyclohexanecarboxylic acid, DMTBS

Chemical compound data from PubChem database. IUPAC Name: [tert-butyl(dimethyl)silyl] cyclohexanecarboxylate. Molecular Formula: C13H26O2Si. Molecular Weight: 242.43. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Patent AT-E400904-T1: [Translated] INTERCHANGEABLE FUEL CARTRIDGE, FUEL CELL UNIT WITH SAID FUEL CARTRIDGE FOR PORTABLE ELECTRONIC DEVICES AND CORRESPONDING DEVICE

A fuel cell assembly including a membrane electrode assembly, an anode plate, a cathode plate, a removable fuel cartridge, and a fuel delivery system. The assembly includes an anode, a cathode, and a polymer electrolyte membrane having a fuel side and an oxygen side. The fuel cartridge includes an expandable fuel bladder for receiving liquid fuel, an expandable pressure member in contact with the bladder for maintaining a positive pressure on the bladder, and a sealable exit port in fluid communication with the bladder. The fuel delivery system delivers fuel from the cartridge to the fuel side of the membrane. An Interface, Control, and Regulator Circuit for Fuel Cell Powered Electronic Device.

Tags: chemistry, innovation, patent, pubchem, research
Organization: U.S. Department of Health & Human Services
Half of Women on Probation or Parole Experience Mental Illness (2008 to 2010 NSDUH)

This report uses 2008 to 2010 National Survey on Drug Use and Health (NSDUH) to assess past year any mental illness (AMI) and serious mental illness (SMI) among women aged 18 to 49 by by past year probation/parole status.

Tags: nsduh-data, probation-parole, samhsa, serious-mental-illness, womens-mental-health
Organization: U.S. Department of Health & Human Services
Evaluating Niger's experience in strengthening supervision, improving availability of child survival drugs through cost recovery, and initiating training for Integrated Management of Childhood Illness (IMCI)

Background
          WHO and UNICEF have recently developed the "Integrated Management of Childhood Illness" (IMCI) as an efficient strategy to assist developing countries reduce childhood mortality. Early experience with IMCI implementation suggests that clinical training is essential but not sufficient for the success of the strategy. Attention needs to be given to strengthening health systems, such as supervision and drug supply.
        
        
          Results
          This paper presents results of evaluating an innovative approach for implementing IMCI in Niger. It starts with strengthening district level supervision and improving the availability of child survival drugs through cost recovery well before the beginning of IMCI clinical training. The evaluation documented the effectiveness of the initial IMCI clinical training and referral.
        
        
          Conclusions
          Strengthening supervision and assuring the availability of essential drugs need to precede the initiation of IMCI Clinical training. Longer term follow up is necessary to confirm the impact of the approach on IMCI preparation and implementation.

Tags: child-mortality, essential-drugs, health-system-strengthening, imci-strategy, nih
Organization: U.S. Department of Health & Human Services
Compound 528593: 4-Hydroxymandelic acid, tris(O-t-butyldimethylsilyl)-

Chemical compound data from PubChem database. IUPAC Name: [tert-butyl(dimethyl)silyl] 2-[tert-butyl(dimethyl)silyl]oxy-2-[4-[tert-butyl(dimethyl)silyl]oxyphenyl]acetate. Molecular Formula: C26H50O4Si3. Molecular Weight: 510.9. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
The major transcription initiation site of the

Background
          The cyclin-dependent kinase inhibitor p27Kip1 is essential for proper control of cell cycle progression. The levels of p27Kip1 are regulated by several mechanisms including transcriptional and translational controls. In order to delineate the molecular details of these regulatory mechanisms it is important to identify the transcription initiation site within the p27Kip1 gene, thereby defining the promoter region of the gene and the 5'-untranslated region of the p27Kip1 mRNA. Although several previous studies have attempted to map p27Kip1 transcription start sites, the results vary widely for both the mouse and human genes. In addition, even though the mouse and human p27Kip1 gene sequences are very highly conserved, the reported start sites are notably different.
        
        
          Results
          In this report, using a method that identifies capped ends of mRNA molecules together with RNase protection assays, we demonstrate that p27Kip1 transcription is initiated predominantly from a single site which is conserved in the human and mouse genes. Initiation at this site produces a 5'-untranslated region of 472 nucleotides in the human p27Kip1 mRNA and 502 nucleotides in the mouse p27Kip1 mRNA. In addition, several minor transcription start sites were identified for both the mouse and human genes.
        
        
          Conclusions
          These results demonstrate that the major transcription initiation sites in the mouse and human p27Kip1 genes are conserved and that the 5'-UTR of the p27Kip1 mRNA is much longer than generally believed. It will be important to consider these findings when designing experiments to identify elements that are involved in regulating the cellular levels of p27Kip1.

Tags: cell-cycle-progression, gene-expression, nih, p27kip1-gene, transcription-initiation
Organization: U.S. Department of Health & Human Services