AndreaBozzo/ceres-open-data-index huggingface dataset:
Results from the 2011 National Survey on Drug Use and Health: Summary of National Findings

This report presents results from the 2011 National Survey on Drug Use and Health (NSDUH). The report includes national estimates of rates of initiation and use of illicit drugs (e.g., marijuana, cocaine, heroin, hallucinogens, inhalants, and the nonmedical use of prescription-type pain relievers, tranquilizers, stimulants, and sedatives), alcohol, and tobacco products and rates of driving under the influence of drugs or alcohol. The report also covers substance use treatment need/receipt and youth risk and prevention measures. Results are provided for age group, gender, pregnancy status, race/ethnicity, education level, employment status, geographic area, parole/probation status. Comparisons are made between 2011 and 2002 to 2010.

Tags: alcohol-tobacco-use, drug-use-survey, mental-health, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Genetic transformation of

Background
          Efficient transformation and regeneration methods are a priority for successful application of genetic engineering to vegetative propagated plants such as grape. The current methods for the production of transgenic grape plants are based on Agrobacterium-mediated transformation followed by regeneration from embryogenic callus. However, grape embryogenic calli are laborious to establish and the phenotype of the regenerated plants can be  altered.
        
        
          Results
          Transgenic grape plants (V. vinifera, table-grape cultivars Silcora and Thompson Seedless) were produced using a method based on regeneration via organogenesis. In vitro proliferating shoots were cultured in the presence of increasing concentrations of N6-benzyl adenine. The apical dome of the shoot was removed at each transplantation which, after three months, produced meristematic bulk tissue characterized by a strong capacity to differentiate adventitious shoots. Slices prepared from the meristematic bulk were used for Agrobacterium-mediated transformation of grape plants with the gene DefH9-iaaM. After rooting on kanamycin containing media and greenhouse acclimatization, transgenic plants were transferred to the field. At the end of the first year of field cultivation, DefH9-iaaM grape plants were phenotypically homogeneous and did not show any morphological alterations in vegetative growth. The expression of DefH9-iaaM gene was detected in transgenic flower buds of both cultivars.
        
        
          Conclusions
          The phenotypic homogeneity of the regenerated plants highlights the validity of this method for both propagation and genetic transformation of table grape cultivars. Expression of the DefH9-iaaM gene takes place in young flower buds of transgenic plants from both grape cultivars.

Tags: genetic-transformation, grape-vine, nih, organogenesis, plant-regeneration
Organization: U.S. Department of Health & Human Services
Computational discovery of sense-antisense transcription in the human and mouse genomes

Overlapping but oppositely oriented transcripts have the potential to form sense-antisense perfect double-stranded (ds) RNA duplexes. A bioinformatics approach has identified over 217 candidate overlapping transcriptional units, bringing the total number of predicted and validated examples of overlapping but oppositely oriented transcripts to over 300.

Tags: genome-mapping, nih, rna-duplexes, sense-antisense-transcription, transcriptional-units
Organization: U.S. Department of Health & Human Services
Immunodetection of nmt55/p54

Background
          We previously identified and characterized a novel 55 kDa nuclear protein, termed nmt55/p54nrb, whose expression was decreased in a subset of human breast tumors. The objective of this study was to determine if this reduced expression in human breast tumors was attributed to the regulation of mRNA transcription or the presence of altered forms of this protein.
        
        
          Results
          Northern blot analysis and ribonuclease protection assay indicated that nmt55/p54nrb mRNA is expressed at varying levels in estrogen receptor positive (ER+) and estrogen receptor negative (ER-) human breast tumors suggesting that reduced expression of nmt55/p54nrb protein in ER- tumors was not due to transcriptional regulation. To determine if multiple protein isoforms are expressed in breast cancer, we utilized Western blot and immunohistochemical analyses, which revealed the expression of an nmt55/p54nrb protein isoform in a subset of ER+ tumors. This subset of ER+ human breast tumors expressed an altered form of nmt55/p54nrb that was undetectable with an amino-terminal specific antibody suggesting that this isoform contains alterations or modifications within the amino terminal domain.
        
        
          Conclusions
          Our study indicates that nmt55/p54nrb protein is post-transcriptionally regulated in human breast tumors leading to reduced expression in ER- tumors and the expression of an amino terminal altered isoform in a subset of ER+ tumors. The potential involvement of nmt55/p54nrb in RNA binding and pre-mRNA splicing may be important for normal cell growth and function; thus, loss or alteration of protein structure may contribute to tumor growth and progression.

Tags: breast-cancer, immunodetection, nih, nmt55p54nrb, protein-isoforms
Organization: U.S. Department of Health & Human Services
NSDUH 2020 Sample Experience Report

This report is a follow-up to the 2020 National Survey on Drug Use and Health (NSDUH)Sample Design Report. It further documents the 2020 NSDUH sample experiences by comparing expected outcomes with what actually occurred, and documenting unexpected issues that came up during the year. A summary of the sample design is included for context.Chapters:Introduces the report and summarizes the impact of the coronavirus 2019 (COVID-19) pandemic on sample design and data collection.Revisits the 2020 sample design.Documents the sample experiences at the third stage of sample selectionDocuments the sample experiences at the fourth stage of sample selectionDocuments the sample experiences at the fifth stage of sample selectionLooks at sampling error, through a computation of design effects and a comparison of observed and expected precisionExamines the Clinical Validation Study sample experience

Tags: mental-health, nsduh-data, samhsa, substance-use, survey-sampling
Organization: U.S. Department of Health & Human Services
Modeling of failure mode in knee ligaments depending on the strain rate

Background
          The failure mechanism of the knee ligament (bone-ligament-bone complex) at different strain rates is an important subject in the biomechanics of the knee. This study reviews and summarizes the literature describing ligament injury as a function of stain rate, which has been published during the last 30 years.
        
        
          Methods
          Three modes of injury are presented as a function of strain rate, and they are used to analyze the published cases. The number of avulsions is larger than that of ligament tearing in mode I. There is no significant difference between the number of avulsions and ligament tearing in mode II. Ligament tearing happens more frequently than avulsion in mode III.
        
        
          Results
          When the strain rate increases, the order of mode is mode I, II, III, I, and II. Analytical models of ligament behavior as a function of strain rate are also presented and used to provide an integrated framework for describing all of the failure regimes. In addition, this study showed the failure mechanisms with different specimens, ages, and strain rates.
        
        
          Conclusion
          There have been several a numbers of studies of ligament failure under various conditions including widely varying strain rates. One issue in these studies is whether ligament failure occurs mid-ligament or at the bone attachment point, with assertions that this is a function of the strain rate. However, over the range of strain rates and other conditions reported, there has appeared to be discrepancies in the conclusions on the effect of strain rate. The analysis and model presented here provides a unifying assessment of the previous disparities, emphasizing the differential effect of strain rate on the relative strengths of the ligament and the attachment.

Tags: avulsion-vs-tearing, knee-ligament-injury, ligament-failure-mode, nih, strain-rate-biomechanics
Organization: U.S. Department of Health & Human Services
Recruitment curve of the soleus H-reflex in chronic back pain and lumbosacral radiculopathy

Background
          Needle EMG may be negative in mild or predominantly sensory lumbosacral radiculopathies. In such cases, an increase in the latency of the soleus H-reflex is a useful diagnostic criterion for establishing sensory fiber compromise at the S1 root level. However, if clinical signs of radicular involvement are lacking, the latency of the H-reflex is normal. We therefore studied the recruitment curve of the soleus H-reflex to investigate whether a change in the electrical threshold for eliciting the H-reflex might be a more sensitive criterion for detecting subclinical S1 root dysfunction.
        
        
          Methods
          Clinical and electrophysiological findings from 26 patients with chronic back pain and radiculopathy were compared with data obtained from 40 healthy subjects.
        
        
          Results
          An increase in the mean H-reflex threshold was the only abnormal electrophysiological finding in patients with no clinical sign of root injury (58%). A decrease in the mean H-reflex amplitude and a prolongation of H-reflex latency was observed in patients with radicular signs (42%). In both patients groups, F-wave and needle EMG studies were normal. No radiological evidence of S1 root compression was found.
        
        
          Conclusions
          The study of the recruitment curve of the soleus H-reflex may be usefully associated to F-wave and needle EMG studies to detect possible S1 root dysfunction in mild lumbosacral radiculopathies. An increase in H-threshold may be the earliest abnormality in the absence of focal neurological signs.

Tags: chronic-back-pain, electrophysiology, h-reflex, lumbosacral-radiculopathy, nih
Organization: U.S. Department of Health & Human Services
Compound 525462: 1-Methylthioethanethiol

Chemical compound data from PubChem database. IUPAC Name: 1-methylsulfanylethanethiol. Molecular Formula: C3H8S2. Molecular Weight: 108.23. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 525108: 2,3-Dichloropropyl isobutyrate

Chemical compound data from PubChem database. IUPAC Name: 2,3-dichloropropyl 2-methylpropanoate. Molecular Formula: C7H12Cl2O2. Molecular Weight: 199.07. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Gallup Poll: Child Abuse Study, 1995

A nationwide random telephone survey of 1,000 households was conducted between August 15 and September 14,1995. The survey assessed parental attitudes regarding methods of discipline; agreement on discipline; fights between partners; child rearing; and childhood experience of punishment, abuse between parents, and sexual abuse.  This survey represents the first national study assessing the validity and reliability of the Parent-Child version of the Conflict Tactics Scale as developed by Straus et al. The maximum margin of error for the survey was +/- 3 percentage points.

Investigators: Gallup Poll News Service

Tags: abuse, care, ndacan, policy, reporting
Organization: U.S. Department of Health & Human Services
Distinct functions of

Background
          In most organisms proper reductional chromosome segregation during meiosis I is strongly correlated with the presence of crossover recombination structures (chiasmata); recombination deficient mutants lack crossovers and suffer meiosis I nondisjunction. We report that these functions are separable in the fission yeast Schizosaccharomyces pombe.
        
        
          Results
          Intron mapping and expression studies confirmed that Rec12 is a member of the Spo11/Top6A topoisomerase family required for the formation of meiotic dsDNA breaks and recombination. rec12-117, rec12-D15 (null), and rec12-Y98F (active site) mutants lacked most crossover recombination and chromosomes segregated abnormally to generate aneuploid meiotic products. Since S. pombe contains only three chromosome pairs, many of those aneuploid products were viable. The types of aberrant chromosome segregation were inferred from the inheritance patterns of centromere linked markers in diploid meiotic products. The rec12-117 and rec12-D15 mutants manifest segregation errors during both meiosis I and meiosis II. Remarkably, the rec12-Y98F (active site) mutant exhibited essentially normal meiosis I segregation patterns, but still exhibited meiosis II segregation errors.
        
        
          Conclusions
          Rec12 is a 345 amino acid protein required for most crossover recombination and for chiasmatic segregation of chromosomes during meiosis I. Rec12 also participates in a backup distributive (achiasmatic) system of chromosome segregation during meiosis I. In addition, catalytically-active Rec12 mediates some signal that is required for faithful equational segregation of chromosomes during meiosis II.

Tags: chromosome-segregation, meiosis-i, nih, recombination-deficient, schizosaccharomyces-pombe
Organization: U.S. Department of Health & Human Services
NSDUH 2018 Sample Design Report

This report details the 2018 sample design for the NSDUH and covers the design overview, target population, and stages of sample selection. The design overview describes how the sample design remains consistent with NSDUH’s designs since 1991 and has extended coverage of the sample since then to include additional resident populations. The 2018 target population for this report comprises a civilian, noninstitutionalized population aged 12 years or older residing within the 50 states and the District of Columbia. There are three stages of sample selection that are explained in terms of how to select and aggregate the appropriate census tracts and segments based on state sampling regions (SSRs) for each state.

Tags: nsduh, samhsa, sample-design, survey-methodology, target-population
Organization: U.S. Department of Health & Human Services
A simple method to assess the oxidative susceptibility of low density lipoproteins

Background
          Oxidative modification of low density lipoproteins (LDL) is recognized as one of the major processes involved in atherogenesis. The in vitro standardized measurement of LDL oxidative susceptibility could thus be of clinical significance. The aim of the present study was to establish a method which would allow the evaluation of oxidative susceptibility of LDL in the general clinical laboratory.
        
        
          Results
          LDL was isolated from human plasma by selective precipitation with amphipathic polymers. The ability of LDL to form peroxides was assessed by measuring thiobarbituric acid reactive substances (TBARS) after incubation with Cu2+ and H2O2. Reaction kinetics showed a three-phase pattern (latency, propagation and decomposition phases) which allowed us to select 150 min as the time point to stop the incubation by cooling and EDTA addition. The mixture Cu2+/H2O2 yielded more lipoperoxides than each one on its own at the same time end-point. Induced peroxidation was measured in normal subjects and in type 2 diabetic patients. In the control group, results were 21.7 ± 1.5 nmol MDA/mg LDL protein, while in the diabetic group results were significantly increased (39.0 ± 3.0 nmol MDA/mg LDL protein; p < 0.001).
        
        
          Conclusion
          a simple and useful method is presented for the routine determination of LDL susceptibility to peroxidation in a clinical laboratory.

Tags: atherogenesis, ldl-oxidation, lipoprotein-peroxidation, nih, tbar-assay
Organization: U.S. Department of Health & Human Services
Dependence, Abuse, and Treatment Tables (Prevalence Estimates) - 5.1 to 5.56

These detailed tables present totals and prevalence estimates of substance dependence/abuse and treatment need/receipt from the 2012 National Survey on Drug Use and Health (NSDUH). Substances examined include illicit drugs, marijuana, cocaine, heroin, hallucinogens, inhalants, and the nonmedical use of prescription-type pain relievers, tranquilizers, stimulants, and sedatives, and alcohol. Results are provided by age group, gender, race/ethnicity, education level, employment status, and geographic area. Comparisons are made between 2012 and 2011.

Tags: drug-dependence, nsduh-data, samhsa, substance-abuse, treatment-prevalence
Organization: U.S. Department of Health & Human Services
Time between Termination of Parental Rights (TPR) and Adoption Finalization: 10/1/2006 - 9/30/2007

This report provides state-specific data from fiscal year 2007 about the time between the termination of parental rights and the adoption finalization for public agency adoptions.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: adoption, data, fiscal, policy, reporting
Organization: U.S. Department of Health & Human Services
Table 21. Needing But Not Receiving Treatment for Illicit Drug Use in the Past Year, by Age Group and State: Percentages, Annual Averages Based on 2010 and 2011 NSDUHs

This report presents State estimates for measures of needing but not receiving treatment for past year illicit drug use based on the combined 2010 and 2011 National Surveys on Drug Use and Health (NSDUHs). Resuts are provided by age group.

Tags: drug-use-treatment, nsduh-data, samhsa, substance-use, unmet-treatment-need
Organization: U.S. Department of Health & Human Services
2019 Uniform Reporting System (URS) Table for Puerto Rico

These are the 2019 Uniform Reporting System (URS) Output Tables for Puerto Rico. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-data, mental-health-services, noms-measures, puerto-rico, samhsa
Organization: U.S. Department of Health & Human Services
Heart rate changes during partial seizures: A study amongst Singaporean patients

Introduction
          Studies in Europe and America showed that tachycardia, less often bradycardia, frequently accompanied partial seizures in Caucasian patients. We determine frequency, magnitude and type of ictal heart rate changes during partial seizures in non-Caucasian patients in Singapore.
        
        
          Methods
          Partial seizures recorded during routine EEGs performed in a tertiary hospital between 1995 and 1999 were retrospectively reviewed. All routine EEGs had simultaneous ECG recording. Heart rate before and during seizures was determined and correlated with epileptogenic focus. Differences in heart rate before and during seizures were grouped into 4 types: (1) >10% decrease; (2) -10 to +20% change; (3) 20–50% increase; (3) >50% increase.
        
        
          Results
          Of the total of 37 partial seizures, 18 were left hemisphere (LH), 13 were right hemisphere (RH) and 6 were bilateral (BL) in onset. 51% of all seizures showed no significant change in heart rate (type 2), 22% had moderate sinus tachycardia (type 3), 11% showed severe sinus tachycardia (type 4), while 16% had sinus bradycardia (type 1). Asystole was recorded in one seizure. Apart from having more tachycardia in bilateral onset seizures, there was no correlation between side of ictal discharge and heart rate response. Compared to Caucasian patients, sinus tachycardia was considerably less frequent. Frequency of bradycardia was similar to those recorded in the literature.
        
        
          Conclusions
          Significant heart rate changes during partial seizures were seen in half of Singaporean patients. Although sinus tachycardia was the most common heart rate change, the frequency was considerably lower compared to Caucasian patients. This might be due to methodological and ethnic differences. Rates of bradycardia are similar to those recorded in the literature.

Tags: electroencephalography, heart-rate-variability, ictal-tachycardia, nih, partial-seizures
Organization: U.S. Department of Health & Human Services
Tribal Consultation on Title IV-E Information Systems Regulations

This report provides a summary of a formal consultation process with tribes regarding the Statewide and Tribal Automated Child Welfare Information System (SACWIS/TACWIS), including comments and questions raised by tribal leaders and representatives, the responses from Children’s Bureau staff, and the intended follow-up by the Division of State Systems.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: assessment, child, policy, regulation, reporting
Organization: U.S. Department of Health & Human Services
Compound 525083: [2-acetyloxy-2-(10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)ethyl] acetate

Chemical compound data from PubChem database. IUPAC Name: [2-acetyloxy-2-(10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)ethyl] acetate. Molecular Formula: C25H40O4. Molecular Weight: 404.6. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 525412: 2-Methyl-4,5-dithiaoctane

Chemical compound data from PubChem database. IUPAC Name: 2-methyl-1-(propyldisulfanyl)propane. Molecular Formula: C7H16S2. Molecular Weight: 164.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services