AndreaBozzo/ceres-open-data-index huggingface dataset:
Denver

Data tables consisting of Excel files with estimates, rates, relative standard errors, trends and confidence intervals, covering 2004-2011, for drug-related emergency department visits for the Denver Metropolitan Statistical Area. Tables are provided for 10 topics (\"analytic categories\") which are defined in the \"Guide to Drug Abuse Warning Trend Tables,\"  a separate document.   Each table includes data for over 500 drugs, including illicit drugs, prescription and over-the-counter medications, dietary supplements, inhalants and alcohol. Includes total visits, gender, age group, race/ethnicity, outcome of visit, drug combinations, number of drugs involved in visit, drug frequency, and drugs confirmed by toxicology. Additional detail is provided for illicit drugs, psychotherapeutic drugs, central nervous system (CNS) drugs, respiratory drugs and cardiovascular drugs.

Tags: drug-abuse-trends, drug-related-ed-visits, emergency-department-data, samhsa, toxicology-confirmed-drugs
Organization: U.S. Department of Health & Human Services
South Carolina: 2011-2012 NSDUH

This report presents South Carolina\'s estimates for 25 measures of substance use and mental health based on the combined 2011 and 2012 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided by State and for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: mental-health, nsduh-data, samhsa, south-carolina, substance-use
Organization: U.S. Department of Health & Human Services
2021 NSDUH Annual National Report

Read key findings from the 2021 National Survey on Drug Use and Health (NSDUH) on substance use, mental health, and treatment. Metrics in the report cover the civilian, noninstitutionalized US population ages 12 and older. Estimates are presented by age group and by race/ethnicity for selected measures. Unlike other NSDUH Annual National Reports, the 2021 report has no discussion of trends over time, because changes in survey methodology mean the indicators are not comparable to past NSDUH estimates.Along with the full report, a set of slides is available that displays the figures from the report.An errata document with corrected information was added in April 2023.

Tags: behavioral-health, mental-health, national-survey, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Prolonged exposure of chromaffin cells to nitric oxide down-regulates the activity of soluble guanylyl cyclase and corresponding mRNA and protein levels

Background
          Soluble guanylyl cyclase (sGC) is the main receptor for nitric oxide (NO) when the latter is produced at low concentrations. This enzyme exists mainly as a heterodimer consisting of one α and one β subunit and converts GTP to the second intracellular messenger cGMP. In turn, cGMP plays a key role in regulating several physiological processes in the nervous system. The aim of the present study was to explore the effects of a NO donor on sGC activity and its protein and subunit mRNA levels in a neural cell model.
        
        
          Results
          Continuous exposure of bovine adrenal chromaffin cells in culture to the nitric oxide donor, diethylenetriamine NONOate (DETA/NO), resulted in a lower capacity of the cells to synthesize cGMP in response to a subsequent NO stimulus. This effect was not prevented by an increase of intracellular reduced glutathione level. DETA/NO treatment decreased sGC subunit mRNA and β1 subunit protein levels. Both sGC activity and β1 subunit levels decreased more rapidly in chromaffin cells exposed to NO than in cells exposed to the protein synthesis inhibitor, cycloheximide, suggesting that NO decreases β1 subunit stability. The presence of cGMP-dependent protein kinase (PKG) inhibitors effectively prevented the DETA/NO-induced down regulation of sGC subunit mRNA and partially inhibited the reduction in β1 subunits.
        
        
          Conclusions
          These results suggest that activation of PKG mediates the drop in sGC subunit mRNA levels, and that NO down-regulates sGC activity by decreasing subunit mRNA levels through a cGMP-dependent mechanism, and by reducing β1 subunit stability.

Tags: cgmp-synthesis, chromaffin-cells, guanylyl-cyclase, nih, nitric-oxide
Organization: U.S. Department of Health & Human Services
Table 18. Illicit Drug Dependence or Abuse in the Past Year, by Age Group and State: Percentages, Annual Averages Based on 2010 and 2011 NSDUHs

This report presents State estimates for measures of past year illicit drug dependence or abuse based on the combined 2010 and 2011 National Surveys on Drug Use and Health (NSDUHs). Resuts are provided by age group.

Tags: drug-dependence, illicit-drug-abuse, nsduh-data, samhsa, substance-use-disorder
Organization: U.S. Department of Health & Human Services
Updated Nonregulatory Guidance from the U.S. Departments of Education and Health and Human Services on Ensuring Educational Stability and Success for Students in Foster Care

This Information Memorandum (IM) notifies child welfare agencies about the release of updated nonregulatory guidance: Nonregulatory Guidance: Ensuring Educational Stability and Success for Students in Foster Care.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: care, foster, guidance, instruction, policy
Organization: U.S. Department of Health & Human Services
Delineation of RAID1, the RACK1 interaction domain located within the unique N-terminal region of the cAMP-specific phosphodiesterase, PDE4D5

Background
          The cyclic AMP specific phosphodiesterase, PDE4D5 interacts with the β-propeller protein RACK1 to form a signaling scaffold complex in cells. Two-hybrid analysis of truncation and mutant constructs of the unique N-terminal region of the cAMP-specific phosphodiesterase, PDE4D5 were used to define a domain conferring interaction with the signaling scaffold protein, RACK1.
        
        
          Results
          Truncation and mutagenesis approaches showed that the RACK1-interacting domain on PDE4D5 comprised a cluster of residues provided by Asn-22/Pro-23/Trp-24/Asn-26 together with a series of hydrophobic amino acids, namely Leu-29, Val-30, Leu-33, Leu-37 and Leu-38 in a 'Leu-Xaa-Xaa-Xaa-Leu' repeat. This was done by 2-hybrid analyses and then confirmed in biochemical pull down analyses using GST-RACK1 and mutant PDE4D5 forms expressed in COS cells. Mutation of Arg-34, to alanine, in PDE4D5 attenuated its interaction with RACK1 both in 2-hybrid screens and in pull down analyses. A 38-mer peptide, whose sequence reflected residues 12 through 49 of PDE4D5, bound to RACK1 with similar affinity to native PDE4D5 itself (Ka circa 6 nM).
        
        
          Conclusions
          The RACK1 Interaction Domain on PDE4D5, that we here call RAID1, is proposed to form an amphipathic helical structure that we suggest may interact with the C-terminal β-propeller blades of RACK1 in a manner akin to the interaction of the helical G-γ signal transducing protein with the β-propeller protein, G-β.

Tags: nih, pde4d5-protein, protein-domain-mapping, rack1-interaction, signaling-scaffold
Organization: U.S. Department of Health & Human Services
Compound 527261: (6,10-Dimethyl-2-methylidene-10-bicyclo[7.2.0]undec-5-enyl)methanol

Chemical compound data from PubChem database. IUPAC Name: (6,10-dimethyl-2-methylidene-10-bicyclo[7.2.0]undec-5-enyl)methanol. Molecular Formula: C15H24O. Molecular Weight: 220.35. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Illinois (IL)

This report presents Illinois\'s estimates for 25 measures of substance use and mental health based on the combined 2009 and 2010 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for Illinois for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: illinois, mental-health, nsduh, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Comparison Between 2018-2020 NSDUH Substate Region Estimates

Substate estimates for these years are no longer available due to methodological concerns with combining 2020 data with data from 2018 and 2019. We apologize for any inconvenience or confusion this may cause.Because of the COVID-19 pandemic, most respondents answered the survey via the web in Quarter 4 of 2020, even though all responses in Quarter 1 were from in-person interviews. It is known that people may respond to the survey differently while taking it online, thus introducing what is called a mode effect.When the state estimates were released, it was assumed that the mode effect was similar for different groups of people. However, later analyses have shown that this assumption should not be made. Because of these analyses, along with concerns about the rapid societal changes in 2020, it was determined that averages across the three years could be misleading.For more detail on this decision, see the 2018-2020substate data page.

Tags: mental-health, methodological-change, samhsa, substance-use, survey-data
Organization: U.S. Department of Health & Human Services
Prenatal Alcohol and Other Drug Exposures in Child Welfare Study: Final Report

This report presents the results of a federally funded study that examined federal and State policies guiding child welfare prenatal substance exposure (PSE) identification and care, child welfare staff awareness and knowledge of PSE and practices to identify affected children and families, how PSE information is shared and documented, and how child welfare agencies interact with caregivers and allied service providers in supporting children and families. The study included interviews with child welfare directors and reviews of State policy documents pertaining to PSE in five States; interviews with child welfare staff and directors (n=171) at 22 agency sites, as well as a survey of allied PSE-relevant service providers (n=271), and a review of local agency-level policy documents; and in-depth interviews with 13 local agency data staff at two States, as well as a survey of 21 allied PSE-relevant service providers, focus groups or interviews with 48 caregivers, and a review of 212 local agency case files. Results from the study are reported and indicate: States reported policy revisions and enhanced collaborative partnerships in response to CAPTA/CARA legislation; defining prenatal exposure as child maltreatment may be a barrier to providing supportive services to families; most staff reported participating in training related to PSE and stated a high level of awareness about the effects of PSE, yet many displayed inaccurate knowledge about the effects of prenatal alcohol syndrome; staff reported inconsistent assessment for PSE; when PSE is a concern, most CW staff reported that they would refer to developmental and early intervention services along with medical providers; PSE information was not consistently located in a single report or location; and among the caregivers who had cared for a child with PSE, few reported that they were fully prepared to do so. Additional findings are reported and recommendations are made.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: assessment, data, policy, reporting, substance
Organization: U.S. Department of Health & Human Services
Children Living with Parents Who Have a Substance Use Disorder

This report uses data from the 2009 to 2014 National Surveys on Drug Use and Health (NSDUHs) to determine the number of children aged 17 or younger living with a parent who had an substance use disorder, an alcohol use disorder or illicit drug use disorder.

Tags: alcohol-use-disorder, children-of-addicts, nsduh-data, samhsa, substance-use-disorder
Organization: U.S. Department of Health & Human Services
Leukocyte adhesion and recruitment, and alpha-1-antitrypsin deficiency: a report from ATS 2001, May 18-23, San Francisco

The program at this year's American Thoracic Society international conference included over 300 scientific and clinical symposia. In this report I have reviewed the data presented on two important areas of lung inflammation, namely leukocyte recruitment and alpha-1-antitrypsin deficiency. Highlights included work from a number of groups identifying the contribution of specific leukocyte adhesion molecules (CD18, CD11a and vascular cell adhesion molecule-1) which varied according to the site and nature of the initial inflammatory stimulus. In addition work was presented examining the contribution of various chemoattractants to the process of leukocyte recruitment in chronic obstructive pulmonary disease, with leukotriene B4 in particular appearing to play a major role. In alpha-1-antitrypsin deficiency other molecules may also be important and work was presented demonstrating the pro-inflammatory potential of alpha-1-antitrypsin polymers in the lungs of these patients. These advances in the understanding of the basic mechanisms of inflammation will, in the future, allow the development of novel anti-inflammatory therapies for a variety of lung diseases.

Tags: alpha-1-antitrypsin, copd-inflammation, leukocyte-adhesion, leukocyte-recruitment, nih
Organization: U.S. Department of Health & Human Services
Exploring the conditional coregulation of yeast gene expression through fuzzy k-means clustering

A heuristically modified version of fuzzy k-means clustering has been used to identify overlapping clusters of yeast genes based on published gene-expression data following the response of yeast cells to environmental changes. A prevalent theme in the regulation of yeast gene expression seems to be the condition-specific coregulation of overlapping sets of genes.

Tags: environmental-response, fuzzy-k-means, gene-coregulation, nih, yeast-gene-expression
Organization: U.S. Department of Health & Human Services
2018 Uniform Reporting System (URS) Table for Delaware

This is the 2018 Uniform Reporting System (URS) Output Tables for Delaware. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-program, delaware, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: District of Columbia, 2014

This is a behavioral health report for the state of District of Columbia. It uses the National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment Services (NSSATS) to address the topics of youth substance use, youth mental health and treatment, adult mental health and treatment, substance use, and substance use treatment for the years 2009 to 2013.

Tags: behavioral-health, dc-health, mental-health, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
2016 Uniform Reporting System (URS) Table for North Dakota

This is the 2016 Uniform Reporting System (URS) Output Tables for North Dakota. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-program, community-mental-health, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
AFCARS Report #26

This report provides preliminary estimates of Adoption and Foster Care Analysis and Reporting System (AFCARS) data for FY 2018. As states are permitted to resubmit AFCARS data, the estimates may change over time. This report reflects all AFCARS data received as of August 22, 2019 related to AFCARS reporting periods through September 30, 2018.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: adoption, assessment, foster, policy, reporting
Organization: U.S. Department of Health & Human Services
Early recovery of microvascular perfusion induced by t-PA in combination with abciximab or eptifibatide during postischemic reperfusion

Background
          GPIIb/IIIa inhibitors abciximab and eptifibatide have been shown to inhibit platelet aggregation in ischemic heart disease. Our aim was to test the efficacy of abiciximab (Reo Pro) or eptifibatide (Integrilin) alone or in combination with plasminogen activator (t-PA) in an experimental model of ischemia reperfusion (I/R) in hamster cheek pouch microcirculation visualized by fluorescence microscopy. Hamsters were treated with saline, or abiciximab or eptifibatide or these drugs combined with t-PA infused intravenously 10 minutes before ischemia and through reperfusion. We measured the microvessel diameter changes, the arteriolar red blood cell (RBC) velocity, the increase in permeability, the perfused capillary length (PCL), and the platelet and leukocyte adhesion on microvessels.
        
        
          Results
          I/R elicited large increases in the platelet and leukocyte adhesion and a decrease in microvascular perfusion. These responses were significantly attenuated by abiciximab or eptifibatide (PCL:70 and 65% at 5–10 mins of reperfusion and 85 and 87% at 30 mins of reperfusion, respectively, p < 0.001) while t-PA combined with abiciximab or eptifibatide, was more effective and microvascular perfusion recovered immediately after postischemic reperfusion.
        
        
          Conclusions
          Platelets are crucial in I/R injury, as shown by the treatment with abicixmab or eptifibatide, which decreased platelet aggregation in microvessels, and also decreased leukocyte adhesion in venules. Arterial vasoconstriction, decreased arterial RBC velocity and alterations in the endothelial barrier with increased permeability delayed the complete restoration of blood flow, while t-PA combined with inhibition of platelet aggregation speeded up the capillary perfusion after reperfusion.

Tags: gpiib-iiia-inhibitors, ischemia-reperfusion, microvascular-perfusion, nih, platelet-aggregation
Organization: U.S. Department of Health & Human Services
Hyposecretion of the adrenal androgen dehydroepiandrosterone sulfate and its relation to clinical variables in inflammatory arthritis

Hypothalamic–pituitary–adrenal underactivity has been reported in rheumatoid arthritis (RA). This phenomenon has implications with regard to the pathogenesis and treatment of the disease. The present study was designed to evaluate the secretion of the adrenal androgen dehydroepiandrosterone sulfate (DHEAS) and its relation to clinical variables in RA, spondyloarthropathy (Spa), and undifferentiated inflammatory arthritis (UIA). Eighty-seven patients (38 with RA, 29 with Spa, and 20 with UIA) were studied, of whom 54 were women. Only 12 patients (14%) had taken glucocorticoids previously. Age-matched, healthy women (134) and men (149) served as controls. Fasting blood samples were taken for determination of the erythrocyte sedimentation rate (ESR), serum DHEAS and insulin, and plasma glucose. Insulin resistance was estimated by the homeostasis-model assessment (HOMAIR). DHEAS concentrations were significantly decreased in both women and men with inflammatory arthritis (IA) (P < 0.001). In 24 patients (28%), DHEAS levels were below the lower extreme ranges found for controls. Multiple intergroup comparisons revealed similarly decreased concentrations in each disease subset in both women and men. After the ESR, previous glucocorticoid usage, current treatment with nonsteroidal anti-inflammatory drugs, duration of disease and HOMAIR were controlled for, the differences in DHEAS levels between patients and controls were markedly attenuated in women (P = 0.050) and were no longer present in men (P = 0.133). We concluded that low DHEAS concentrations are commonly encountered in IA and, in women, this may not be fully explainable by disease-related parameters. The role of hypoadrenalism in the pathophysiology of IA deserves further elucidation. DHEA replacement may be indicated in many patients with IA, even in those not taking glucocorticoids.

Tags: dheas-levels, inflammatory-arthritis, nih, rheumatoid-arthritis, spondyloarthropathy
Organization: U.S. Department of Health & Human Services
Risk and Protective Factors and Estimates of Substance Use Initiation: Results from the 2016 National Survey on Drug Use and Health

This report presents results from the 2016 National Survey on Drug Use and Health (NSDUH) for people aged 12 or older regarding the perceived harmfulness of using cigarettes, alcohol, and specific illicit drugs as well as the perceived availability of substances. Estimates are presented for specific age groups. Estimates of the perceived great risk of harm associated with the use of marijuana, cocaine, alcohol, and cigarettes also are presented according to whether people initiated use of these substances in the past year.

Tags: initiation-age, nsduh-data, risk-perception, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
The use of cephalad cannulae to monitor jugular venous oxygen content during extracorporeal membrane oxygenation

Background:
          When used during extracorporeal membrane oxygenation (ECMO), jugular venous bulb catheters, known as cephalad cannulae, increase venous drainage, augment circuit flow and decompress cerebral venous pressure. Optimized cerebral oxygen delivery during ECMO may contribute to a reduction in neurological morbidity. This study describes the use of cephalad cannulae and identifies rudimentary data for jugular venous oxygen saturation (JVO2) and arterial to jugular venous oxygen saturation difference (AVDO2) in this patient population.
        
        
          Results:
          Patients on venoarterial (VA) ECMO displayed higher JVO2 (P < 0.01) and lower AVDO2 (P = 0.01) than patients on venovenous (VV) ECMO (P < 0.01). During VV ECMO, JVO2 was higher and AVDO2 lower when systemic pH was < 7.35 rather than > 7.4 (P = 0.01). During VA ECMO, similar differences in AVDO2 but not in JVO2 were observed at different pH levels (P = 0.01).
        
        
          Conclusions:
          Jugular venous saturation and AVDO2 were influenced by systemic pH, ECMO type and patient age. These data provide the foundation for normative values of JVO2 and AVDO2 in neonates and children treated with ECMO.

Tags: cephalad-cannulae, cerebral-oxygenation, ecmo-outcomes, jugular-venous-oxygen, nih
Organization: U.S. Department of Health & Human Services
Boston: Drug-Related Emergency Department Visits, 2004-2011 - Suicide Attempts

Excel file with estimates, rates, relative standard errors, trends and confidence intervals for all drug-related emergency department (ED) visits involving suicide attempts in the Boston metropolitan area, covering 2004-2011.  Drug-related suicide attempts include visits for drug overdoses and for suicide attempts by other means (e.g., using a firearm) if drugs were involved or related to the suicide attempt.

Tags: boston-metro, drug-overdose, emergency-department, samhsa, suicide-attempts
Organization: U.S. Department of Health & Human Services