AndreaBozzo/ceres-open-data-index huggingface dataset:
Phospholipase Cδ regulates germination of

Background
          Many eukaryotes, including plants and fungi make spores that resist severe environmental stress. The micro-organism Dictyostelium contains a single phospholipase C gene (PLC); deletion of the gene has no effect on growth, cell movement and differentiation. In this report we show that PLC is essential to sense the environment of food-activated spores.
        
        
          Results
          Plc-null spores germinate at alkaline pH, reduced temperature or increased osmolarity, conditions at which the emerging amoebae can not grow. In contrast, food-activated wild-type spores return to dormancy till conditions in the environment allow growth. The analysis of inositol 1,4,5-trisphosphate (IP3) levels and the effect of added IP3 uncover an unexpected mechanism how PLC regulates spore germination: i) deletion of PLC induces the enhanced activity of an IP5 phosphatase leading to high IP3 levels in plc-null cells; ii) in wild-type spores unfavourable conditions inhibit PLC leading to a reduction of IP3 levels; addition of exogenous IP3 to wild-type spores induces germination at unfavourable conditions; iii) in plc-null spores IP3 levels remain high, also at unfavourable environmental conditions.
        
        
          Conclusions
          The results imply that environmental conditions regulate PLC activity and that IP3 induces spore germination; the uncontrolled germination of plc-null spores is not due to a lack of PLC activity but to the constitutive activation of an alternative IP3-forming pathway.

Tags: dictyostelium, inositol-trisphosphate, nih, phospholipase-c, spore-germination
Organization: U.S. Department of Health & Human Services
2010 CMHS Uniform Reporting System (URS) Output Tables for Texas

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2010. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, national-outcome-measures, samhsa, texas-mental-health
Organization: U.S. Department of Health & Human Services
Tribal Courts and Child Welfare: Revising Your Children’s Code

This Child Welfare Information Gateway Podcast is available on Apple Podcasts
  
  

, GooglePlay
  
  

, Spotify
  
  

, Stitcher
  
  

, SoundCloud
  
  

, and the Child Welfare Information Gateway
  
  

 website. Subscribe to receive new episodes as they are released.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: affair, child, law, legal, policy
Organization: U.S. Department of Health & Human Services
Compound 527347: 16,20,24,28-Tetramethyl-tetratriacontyl cyanide

Chemical compound data from PubChem database. IUPAC Name: 17,21,25,29-tetramethylhexatriacontanenitrile. Molecular Formula: C40H79N. Molecular Weight: 574.1. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 525575: N,N-Dimethyl-N'-(3-methoxyphenyl)-p-methoxybenzamidine

Chemical compound data from PubChem database. IUPAC Name: 4-methoxy-N'-(3-methoxyphenyl)-N,N-dimethylbenzenecarboximidamide. Molecular Formula: C17H20N2O2. Molecular Weight: 284.35. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Adults with Mental Illness or Substance Use Disorder Account for 40 Percent of All Cigarettes Smoked (2009 to 2011 NSDUH)

This report uses 2009 to 2011 National Survey on Drug Use and Health (NSDUH) to assess past month cigarette use among adults aged 18 or older by whether they have past year any mental illness (AMI) or past year substance use disorder.

Tags: cigarette-smoking, mental-health, nsduh-data, samhsa, substance-use-disorder
Organization: U.S. Department of Health & Human Services
Tissue factor as a proinflammatory agent

Tissue factor (TF) is a transmembrane glycoprotein and the main triggering element of blood coagulation. TF expression on monocytes and endothelial cells is induced by exposure to endotoxin, tumor necrosis factor, and IL-1 and is considered to appear in consequence of inflammation. In order to assess the proinflammatory capacity of TF itself, the recombinant extracellular domain of TF was injected intra-articularly into healthy mice. To characterize the role of immune cells in the TF-induced arthritis, mice deprived of lymphocytes, neutrophils and monocytes were used. Histomorphological analysis of the joints with respect to inflammatory cell infiltration, pannus formation and erosion formation revealed development of arthritis in 80% of animals injected with TF. In most of the cases synovial proliferation was accompanied by pannus formation and cartilage destruction. Inflammatory cell infiltrate consisted of CD4-Mac1+ macrophages. Depletion of monocytes was, however, not enough to abolish inflammation. Indeed, combined deficiency of monocytes and lymphocytes was required to prevent inflammation following the injection of TF. We observed that TF induced chemokine production (MIP-1α and RANTES), but did not induce a proliferative response nor cytokine release by mouse spleen cells. TF has strong inflammatogenic properties mediated predominantly by monocytes and their release of chemokines. Our study shows that TF can simultaneously trigger the immune and coagulation systems.

Tags: arthritis-inflammation, mouse-model, nih, synovial-proliferation, tissue-factor
Organization: U.S. Department of Health & Human Services
Compound 525220: Chloromethyl 7-chloroheptanoate

Chemical compound data from PubChem database. IUPAC Name: chloromethyl 7-chloroheptanoate. Molecular Formula: C8H14Cl2O2. Molecular Weight: 213.1. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
The validity of self-reported weight in US adults: a population based cross-sectional study

Background
          Investigating the validity of the self-reported values of weight allows for the proper assessment of studies using questionnaire-derived data. The study examined the accuracy of gender-specific self-reported weight in a sample of adults. The effects of age, education, race and ethnicity, income, general health and medical status on the degree of discrepancy (the difference between self-reported weight and measured weight) are similarly considered.
        
        
          Methods
          The analysis used data from the US Third National Health and Nutrition Examination Survey. Self-reported and measured weights were abstracted and analyzed according to sex, age, measured weight, self-reported weight, and body mass index (BMI). A proportional odds model was applied.
        
        
          Results
          The weight discrepancy was positively associated with age, and negatively associated with measured weight and BMI. Ordered logistic regression modeling showed age, race-ethnicity, education, and BMI to be associated with the degree of discrepancy in both sexes. In men, additional predictors were consumption of more than 100 cigarettes and the desire to change weight. In women, marital status, income, activity level, and the number of months since the last doctor's visit were important.
        
        
          Conclusions
          Predictors of the degree of weight discrepancy are gender-specific, and require careful consideration when examined.

Tags: body-mass-index, nhanes-iii, nih, self-reported-weight, weight-accuracy
Organization: U.S. Department of Health & Human Services
Sildenafil (Viagra) for male erectile dysfunction: a meta-analysis of clinical trial reports

Background
          Evaluation of company clinical trial reports could provide information for meta-analysis at the commercial introduction of a new technology.
        
        
          Methods
          Clinical trial reports of sildenafil for erectile dysfunction from September 1997 were used for meta-analysis of randomised trials (at least four weeks duration) and using fixed or dose optimisation regimens. The main outcome sought was an erection, sufficiently rigid for penetration, followed by successful intercourse, and conducted at home.
        
        
          Results
          Ten randomised controlled trials fulfilled the inclusion criteria (2123 men given sildenafil and 1131 placebo). NNT or NNH were calculated for important efficacy, adverse event and discontinuation outcomes. Dose optimisation led to at least 60% of attempts at sexual intercourse being successful in 49% of men, compared with 11% with placebo; the NNT was 2.7 (95% confidence interval 2.3 to 3.3). For global improvement in erections the NNT was 1.7 (1.6 to 1.9). Treatment-related adverse events occurred in 30% of men on dose optimised sildenafil compared with 11% on placebo; the NNH was 5.4 (4.3 to 7.3). All cause discontinuations were less frequent with sildenafil (10%) than with placebo (20%). Sildenafil dose optimisation gave efficacy equivalent to the highest fixed doses, and adverse events equivalent to the lowest fixed doses.
        
        
          Conclusion
          This review of clinical trial reports available at the time of licensing agreed with later reviews that had many more trials and patients. Making reports submitted for marketing approval available publicly would provide better information when it was most needed, and would improve evidence-based introduction of new technologies.

Tags: clinical-trials, erectile-dysfunction, meta-analysis, nih, sildenafil
Organization: U.S. Department of Health & Human Services
Compound 528516: Hexadecane, 4-pentyl

Chemical compound data from PubChem database. IUPAC Name: 6-propyloctadecane. Molecular Formula: C21H44. Molecular Weight: 296.6. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Enhancing a SACWIS to Collect and Report NYTD Data

This brief summarizes guidance on NYTD reporting in a statewide automated child welfare information system (SACWIS) environment (ACYF-CB-PI-10-04) with examples of strategies states have used to develop SACWIS enhancements to collect and report NYTD data.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: data, guidance, instruction, policy, reporting
Organization: U.S. Department of Health & Human Services
The NSDUH Report: Trends in Exposure to Substance Use Prevention Messages among Adolescents

This report uses 2002 to 2011 National Survey on Drug Use and Health (NSDUH) to assess adolescents aged 12 to 17’s past year exposure to substance use prevention messages from their parents and through media sources, school, and non-school programs.  Results are shown by age group, gender, and year.

Tags: adolescent-substance-use, nsduh-data, prevention-messages, samhsa, youth-drug-prevention
Organization: U.S. Department of Health & Human Services
Use of complementary/alternative therapies by women with advanced-stage breast cancer

Background
          This study sought to describe the pattern of complementary/alternative medicine (CAM) use among a group of patients with advanced breast cancer, to examine the main reasons for their CAM use, to identify patient's information sources and their communication pattern with their physicians.
        
        
          Methods
          Face-to-face structured interviews of patients with advanced-stage breast cancer at a comprehensive oncology center.
        
        
          Results
          Seventy three percent of patients used CAM; relaxation/meditative techniques and herbal medicine were the most common. The most commonly cited primary reason for CAM use was to boost the immune system, the second, to treat cancer; however these reasons varied depending on specific CAM therapy. Friends or family members and mass media were common primary information source's about CAM.
        
        
          Conclusions
          A high proportion of advanced-stage breast cancer patients used CAM. Discussion with doctors was high for ingested products. Mass media was a prominent source of patient information. Credible sources of CAM information for patients and physicians are needed.

Tags: advanced-stage-cancer, alternative-medicine, breast-cancer, cam-therapy, nih
Organization: U.S. Department of Health & Human Services
2020 Uniform Reporting System (URS) Table For New Mexico

This is the 2020 Uniform Reporting System (URS) Output Tables for New Mexico. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: mental-health-services, national-outcome-measures, new-mexico, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
4.12b Facilities offering services in sign language for the hearing impaired and in languages other than English, by facility operation and primary focus of facility: 2010. Percent

This is a National Survey of Substance Abuse Treatment Services (N-SSATS) data table showing facilities offering services in sign language for the hearing impaired and in languages other than English, by facility operation and primary focus of facility in 2010. N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 States, the District of Columbia, and other U.S. jurisdictions.

Tags: hearing-impaired, language-access, samhsa, sign-language-services, substance-abuse-treatment
Organization: U.S. Department of Health & Human Services
Compound 527285: Citronellyl isooctanoate

Chemical compound data from PubChem database. IUPAC Name: 3,7-dimethyloct-6-enyl 6-methylheptanoate. Molecular Formula: C18H34O2. Molecular Weight: 282.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2021 Uniform Reporting System (URS) Table For Oregon

This is the 2021 Uniform Reporting System (URS) Output Tables for Oregon. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, evidence-based-practices, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Effect of alpha-tocopherol on pulmonary antioxidant defence system and lipid peroxidation in cigarette smoke inhaling mice

Background
          Free radicals generated in biological systems by cigarette smoke (CS) inhalation can cause oxidative stress in tissues, resulting in lipid peroxidation (LPO). In view of the antioxidant properties of α-tocopherol (AT), in the present study, effects of AT on antioxidant defence system and LPO were investigated in mice inhaling CS for different time intervals.
        
        
          Results
          Male Balb/c mice were fed orally with AT (5 I.U./Kg.b.wt.) and /or exposed to CS for 2, 4, 6 or 8 weeks. No effect was observed on body growth, diet consumption, water intake and lung weight due to AT and /or CS treatment in any of the groups as compared to their control counterparts. After two weeks of treatment, no change in LPO, reduced glutathione (GSH) levels and antioxidant enzymes were observed except for glutathione reductase (GR) which increased in all the treated groups. A significant increase in pulmonary LPO levels was observed in mice exposed to CS inhalation for 4, 6 or 8 weeks. There was a gradual increase in the LPO levels as the extent of CS inhalation increased from 4 to 8 weeks. However, the extent of increase in LPO levels due to CS exposure for 4, 6 or 8 weeks in the mice treated with AT was comparatively less. A significant decrease in the GSH levels was also observed in all the animals exposed to CS for 4, 6 or 8 weeks. There was a significant increase in the activities of catalase, glutathione peroxidase (GSH-Px) and GR observed in all the groups exposed to CS for 4,6 or 8 weeks. The increase in above antioxidant enzymes seems to be insufficient to combat the oxidative stress posed by CS inhalation. There was a marked decrease observed in the LPO levels in the animals treated with AT alone for 4, 6, or 8 weeks, when compared to their control counterparts. However, the supplementation of AT for 4, 6 or 8 weeks demonstrated a significant increase in GSH levels.
        
        
          Conclusion
          It appears from our studies that AT exhibits its antioxidant role either directly by scavenging the oxidative species or indirectly by modulating the GSH levels.

Tags: alpha-tocopherol, cigarette-smoke, lipid-peroxidation, nih, pulmonary-antioxidant
Organization: U.S. Department of Health & Human Services
Survey of the knowledge, attitude and practice of Nigerian surgery trainees to HIV-infected persons and AIDS patients

Background
          The incidence of HIV infection and AIDS is rising in Nigeria. Surgeons are at risk of occupationally acquired infection as a result of intimate contact with the blood and body fluids of patients. This study set out to determine the knowledge, attitude and risk perception of Nigerian surgery residents to HIV infection and AIDS.
        
        
          Methods
          A self-administered postal questionnaire was sent to all surgery trainees in Nigeria in 1997.
        
        
          Results
          Parenteral exposure to patients' blood was reported as occurring 92.5% times, and most respondents assessed their risk of becoming infected with HIV as being moderate at 1–5%. The majority of the respondents were not aware of the CDC guidelines on universal precautions against blood-borne pathogens. Most support a policy of routinely testing all surgical patients for HIV infection but 76.8% work in centers where there is no policy on parenteral exposure to patients' blood and body fluids. Most (85.6%) do not routinely use all the protective measures advocated for the reduction of transmission of blood borne pathogens during surgery, with the majority ascribing this to non-availability. Most want surgeons to be the primary formulators of policy on HIV and surgery while not completely excluding other stakeholders.
        
        
          Conclusions
          The study demonstrates the level of knowledge, attitude and practice of Nigerian surgery trainees in 1997 and the need for policy guidelines to manage all aspects of the healthcare worker (HCW), patients, and HIV/AIDS interaction.

Tags: hiv-aids, nigeria, nih, occupational-exposure, surgery-residents
Organization: U.S. Department of Health & Human Services
Compound 525064: Methyl 10-hydroxydecanoate, TMS

Chemical compound data from PubChem database. IUPAC Name: methyl 10-trimethylsilyloxydecanoate. Molecular Formula: C14H30O3Si. Molecular Weight: 274.47. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 525512: Cycloheptanethiol

Chemical compound data from PubChem database. IUPAC Name: cycloheptanethiol. Molecular Formula: C7H14S. Molecular Weight: 130.25. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 528362: 1,3,5-Oxathiazine, perhydro, 2,4,6-trimethyl

Chemical compound data from PubChem database. IUPAC Name: 2,4,6-trimethyl-1,3,5-oxathiazinane. Molecular Formula: C6H13NOS. Molecular Weight: 147.24. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Trafficking Victim Assistance Program Data

TVAP grant project participants through the grantees on a monthly, quarterly, or annual basis, including participant demographics (age, sex, and country of origin), type of trafficking experienced (sex, labor, or both), enrollment status, types of services and benefits provided, types of health screening and medical services received, the names of the entities providing medical services, the amount of money expended on each type of medical service provided, types of partnerships developed through the grant with subrecipients, and the types of training and technical assistance provided to subrecipient organizations or other partners.

<b>Units of Response: </b>Foreign National Victims of Human Trafficking

<b>Type of Data: </b>Administrative

<b>Tribal Data: </b>Unavailable

<b>COVID-19 Data: </b>Unavailable

<b>Periodicity: </b>Annual

<b>SORN: </b>Not Applicable

<b>Data Use Agreement: </b>Unavailable

<b>Data Use Agreement Location: </b>Unavailable

<b>Equity Indicators: </b>Disability;Ethnicity;Gender Identity;Housing Status;Indigenous Population;Race

<b>Granularity: </b>Unavailable

<b>Spatial: </b>United States

<b>Geocoding: </b>Country of Origin

Tags: anti-trafficking
Organization: U.S. Department of Health & Human Services
Substance Use and Mental Health Estimates from the 2013 National Survey on Drug Use and Health: Overview of Findings

This report uses 2013 National Survey on Drug Use and Health (NSDUH) to assess the prevalence of substance use and mental disorders among those aged 12 or older, adolescents aged 12 to 17, and adults aged 18 or older and the receipt of treatment/services for behavioral health issues. The 2013 rates of suicide ideation and rates of co-occurring substance use and mental health disorders are also presented.

Tags: behavioral-health, mental-health, samhsa, substance-use, suicidal-ideation
Organization: U.S. Department of Health & Human Services