AndreaBozzo/ceres-open-data-index huggingface dataset:
2022 Uniform Reporting System (URS) Table For Connecticut

This is the 2022 Uniform Reporting System (URS) Output Tables for Connecticut. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-program, community-mental-health, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
CCWIS - Build or Buy?

A discussion with four states who have chosen different approaches for their child welfare information technology projects, each with a unique story to tell about their experience. State panelists discuss their key drivers, considerations for staffing and capacity needs, impacts to their states’ child welfare business process, and lessons learned.

Audio Description Version

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: child, policy, scope, sery, time
Organization: U.S. Department of Health & Human Services
The farnesyl transferase inhibitor RPR-130401 does not alter radiation susceptibility in human tumor cells with a K-Ras mutation in spite of large changes in ploidy and lamin B distribution

Background
          Growth inhibition by RPR-130401, a non-peptidomimetic farnesyltransferase inhibitor, was investigated without or with combined exposure to ionizing radiation in three human tumor cell lines (HCT-116, MiAPaCa-2 and A-549) bearing a point mutation in the K-Ras gene.
        
        
          Results
          RPR-130401 inhibited cell growth with an IC50 of 50 nM (HCT-116), 120 nM (MiAPaCa-2) and 710 nM (A-549), with a poor incidence of apoptosis. The drug brought about G1 and S phase depletion together with arrest of cells in G2 phase and induced a significant accumulation of hyperploid cells showing active S phase DNA synthesis, with HCT-116 and A-549 cells being the most and least responsive, respectively. The drug also produced dramatic changes of the nuclear lamin B pattern, without lamin B cleavage and perturbation of the actin cytoskeleton. On the other hand, RPR-130401 elicited strictly additive interaction in combined treatment with ionizing radiation with regard to cell kill, altered cell cycle progression and induced hyperploidy.
        
        
          Conclusions
          The data suggest that disruption of orderly progression through mitosis and cytokinesis, is a major outcome of drug action and that this effect proceeds from inhibition of lamin B farnesylation. It is anticipated from the strict additivity of RPR-130401 and radiation that neither induced radiation resistance nor acute or late complications of radiotherapy, should occur in combined treatment with RPR-130401.

Tags: farnesyltransferase-inhibitor, k-ras-mutation, nih, radiation-susceptibility, tumor-cell-lines
Organization: U.S. Department of Health & Human Services
14th NCCAN Commissioner's Award Book

The ACYF 2003 Commissioner's Awards book provides descriptions and photographs of the honorees from 46 states, the District of Columbia, and 5 territories who were recognized for their exceptional contributions to the prevention and treatment of child abuse and neglect.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: abuse, grant, neglect, policy, prevention
Organization: U.S. Department of Health & Human Services
Compound 525429: 2-Methyl-2-(methylsulfanyl)butane

Chemical compound data from PubChem database. IUPAC Name: 2-methyl-2-methylsulfanylbutane. Molecular Formula: C6H14S. Molecular Weight: 118.24. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 525661: p-Bromobenzylidene-(4-ethoxyphenyl)-amine

Chemical compound data from PubChem database. IUPAC Name: 1-(4-bromophenyl)-N-(4-ethoxyphenyl)methanimine. Molecular Formula: C15H14BrNO. Molecular Weight: 304.18. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 525529: (3-Chloro-4-octyloxy-phenyl)-acetic acid, methyl ester

Chemical compound data from PubChem database. IUPAC Name: methyl 2-(3-chloro-4-octoxyphenyl)acetate. Molecular Formula: C17H25ClO3. Molecular Weight: 312.8. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 525493: 5-Methyl-3-thia-1-hexanethiol

Chemical compound data from PubChem database. IUPAC Name: 2-(2-methylpropylsulfanyl)ethanethiol. Molecular Formula: C6H14S2. Molecular Weight: 150.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Forced oscillation assessment of respiratory mechanics in ventilated patients

The forced oscillation technique (FOT) is a method for non-invasively assessing respiratory mechanics that is applicable both in paralysed and non-paralysed patients. As the FOT requires a minimal modification of the conventional ventilation setting and does not interfere with the ventilation protocol, the technique is potentially useful to monitor patient mechanics during invasive and noninvasive ventilation. FOT allows the assessment of the respiratory system linearity by measuring resistance and reactance at different lung volumes or end-expiratory pressures. Moreover, FOT allows the physician to track the changes in patient mechanics along the ventilation cycle. Applying FOT at different frequencies may allow the physician to interpret patient mechanics in terms of models with pathophysiological interest. The current methodological and technical experience make possible the implementation of portable and compact computerised FOT systems specifically addressed to its application in the mechanical ventilation setting.

Tags: airway-resistance, forced-oscillation, nih, respiratory-mechanics, ventilated-patients
Organization: U.S. Department of Health & Human Services
FY 2008 Children's Bureau Discretionary Grant and Cooperative Agreement Awards

This document provides a list of Children's Bureau discretionary grants and cooperative agreements awarded in fiscal year 2008:

Supporting Evidence-Based Home Visitation Programs to Prevent Child Abuse and Neglect (CFDA # 93.670)
Up to $500,000 per year for 5 years.

Cooperative Agreements for Child Welfare Technical Assistance Implementation Centers (CFDA # 93.652)
Up to $1,410,000 per year for 5 years.

CAPTA: National Quality Improvement Center on Preventing the Abuse and Neglect of Infants and Young Children (CFDA # 93.670)
Up to $1,700,000 per year for 5 years.

CAPTA: National Quality Improvement Center on Differential Response in Child Protective Services (CFDA # 93.670)
Up to $2,000,000 per year for 5 years.

Adoption Opportunities: Diligent Recruitment of Families for Children in the Foster Care System (CFDA # 93.652)
Up to $400,000 per year for 5 years.

Child Welfare Training: National Child Welfare Workforce Initiatives (CFDA # 93.648)
Up to $3,300,000 per year for 5 years.

Child Welfare Training: Curriculum Development and Evaluation for Healthy Marriage and Relationship Education (CFDA # 93.648)
Up to $250,000 per year for 5 years.

Abandoned Infants Assistance: Comprehensive Support Services for Families Affected by Substance Abuse and/or HIV/AIDS (CFDA # 93.551)
Up to $475,000 per year for 4 years.

Grants to Tribes, Tribal Organizations, and Migrant Programs for Community-Based Child Abuse Prevention Programs (CFDA # 93.590)
Up to $138,963 per year for 3 years.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: abuse, fiscal, grant, neglect, policy
Organization: U.S. Department of Health & Human Services
Arterial Wall Properties and Womersley Flow in Fabry Disease

Background
          Fabry disease is an X-linked recessive lysosomal storage disease resulting in the cellular accumulation of globotriaosylceramide particularly globotriaosylceramide. The disease is characterized by a dilated vasculopathy with arterial ectasia in muscular arteries and arterioles. Previous venous plethysomographic studies suggest enhanced endothelium-dependent vasodilation in Fabry disease indicating a functional abnormality of resistance vessels.
        
        
          Methods
          We examined the mechanical properties of the radial artery in Fabry disease, a typical fibro-muscular artery. Eight control subjects and seven patients with Fabry disease had a right brachial arterial line placed allowing real time recording of intra-arterial blood pressure. Real time B-mode ultrasound recordings of the right radial artery were obtained simultaneously allowing calculation of the vessel wall internal and external diameter, the incremental Young's modulus and arterial wall thickness. By simultaneously measurement of the distal index finger-pulse oximetry the pulse wave speed was calculated. From the wave speed and the internal radial artery diameter the volume flow was calculated by Womersley analysis following truncation of the late diastolic phase.
        
        
          Results
          No significant difference was found between Fabry patients and controls for internal or external arterial diameters, the incremental Young's modulus, the arterial wall thickness, the pulse wave speed and the basal radial artery blood flow. Further, no significant difference was found for the radial artery blood flow in response to intra-arterial acetylcholine or sodium nitroprusside. Both drugs however, elevated the mean arterial flow.
        
        
          Conclusions
          The current study suggests that no structural or mechanical abnormality exists in the vessel wall of fibro-muscular arteries in Fabry disease. This may indicate that a functional abnormality downstream to the conductance vessels is the dominant feature in development Fabry vasculopathy.

Tags: arterial-properties, fabry-disease, nih, vascular-disease, womersley-flow
Organization: U.S. Department of Health & Human Services
Compound 525641: N,N-Dimethyl-N'-octyl-p-methylbenzamidine

Chemical compound data from PubChem database. IUPAC Name: N,N,4-trimethyl-N'-octylbenzenecarboximidamide. Molecular Formula: C18H30N2. Molecular Weight: 274.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2020 Uniform Reporting System (URS) Table For Wisconsin

This is the 2020 Uniform Reporting System (URS) Output Tables for Wisconsin. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-data, mental-health-services, national-outcome-measures, samhsa, substance-abuse-treatment
Organization: U.S. Department of Health & Human Services
Estimation of genetic distances from human and mouse introns

Background
          Using genetic distances measured from exons, it has been observed that the mutation rate is not constant along mammalian chromosomes. Exons constitute only 1% of the human genome, however, and thus they cannot provide a complete picture of the mutational variation in the genome.
        
        
          Results
          I calculated genetic distances between 504 human introns and their orthologous mouse counterparts from a set of 63 pairs of human and mouse genes scattered through the genome using a recently developed method that can extract reliably aligned regions from the introns in an objective manner. I found a significant correlation between the genetic distance measured in the conserved intron segments and the synonymous and nonsynonymous distances measured in the corresponding coding exons, indicating that genes with fast-evolving exons tend to have fast-evolving introns, and vice versa.
        
        
          Conclusions
          These results indicate that introns, which extend over almost a quarter of the human genome, contain useful information for fully understanding the mutational dynamics of human and mouse genomes. This work also supports the idea that there is a mutational force that fluctuates nonrandomly along the genome, and shows for the first time that this force affects the introns and the synonymous and nonsynonymous positions in the exons of the genes simultaneously.

Tags: genetic-distance, human-mouse-comparison, intron-evolution, mutation-rate, nih
Organization: U.S. Department of Health & Human Services
Longitudinal Pathways to Resilience in Maltreated Children

The objectives of this study were as follows: (1) To investigate stability and change in the longitudinal course of adaptation and maladaptation in maltreated and nonmaltreated low-income youth.  (2) To differentiate subgroups of maltreated children who evidence divergence in their longitudinal developmental course, including resilient children as well as children who show continuity of negative adaptation.  (3) To examine child characteristics, maltreatment experiences, family features, and aspects of the social ecology as mediators and moderators of individual differences in the developmental pathways exhibited longitudinally by maltreated and nonmaltreated youth.  (4) To identify factors that may promote resilient adaptation in maltreated children. To address these critical concerns, this investigation built upon a prior one-year longitudinal study funded by NCCAN (Cicchetti, Manly, & Lynch, 1994).  Prospective follow-up assessments of 300 six- to twelve-year-old low income, maltreated and nonmaltreated children were targeted at years three and four beyond the initial baseline assessments.  A total of 300 school-aged children were included in the original study (Dataset #096).  Of these, 263 were obtained at year three and 249 at year four.  Data regarding children's adaptation and current symptomatology was collected in the context of a summer camp program that the children attended.  In addition, home visits were conducted concurrently with the third year child camp assessments, during which time the parent or primary caregiver of each child in the study was interviewed.  Finally, information regarding children's history of maltreatment was scored from updated DSS records according to our maltreatment classification system.

Investigators: Dante Cicchetti, Ph.D.

University of Rochester, Rochester, NY



Fred Rogosch, Ph.D.

Mount Hope Family Center, Rochester, NY



Jody Todd Manly, Ph.D.

University of Rochester, Rochester, NY



Michael Lynch, Ph.D.

University of Rochester, Rochester, NY

Tags: abuse, care, ndacan, policy, reporting
Organization: U.S. Department of Health & Human Services
2011-2012 NSDUH: Other Sources of State-level Data

A variety of surveys and data systems other than the National Survey on Drug Use and Health (NSDUH) collect data on substance use and mental health problems. It is useful to consider the results of these other studies when discussing NSDUH data. This document briefly describes one of these other data systems that publish State estimates and presents selected comparisons with NSDUH results. The State-level survey that collects data on substance use discussed in this document is the Behavioral Risk Factor Surveillance System (BRFSS), sponsored by the Centers for Disease Control and Prevention (CDC). Another CDC data system that provides State-level substance use estimates for most but not all States is the Youth Risk Behavior Survey (YRBS).

Tags: brfss, mental-health, samhsa, state-level-data, substance-use
Organization: U.S. Department of Health & Human Services
Bilateral linear scleroderma "en coup de sabre" associated with facial atrophy and neurological complications

Background
          Linear scleroderma "en coup de sabre" (LSCS) usually affects one side of the face and head in the frontoparietal area with band-like indurated skin lesions. The disease may be associated with facial hemiatrophy. Various ophthalmological and neurological abnormalities have been observed in patients with LSCS. We describe an unusual case of LSC.
        
        
          Case presentation
          A 23 year old woman presented bilateral LSCS and facial atrophy. The patient had epileptic seizures as well as oculomotor and facial nerve palsy on the left side which also had pronounced skin involvement. Clinical features of different stages of the disease are presented.
        
        
          Conclusions
          The findings of the presented patient with bilateral LSCS and facial atrophy provide further evidence for a neurological etiology of the disease and may also indicate that classic progressive facial hemiatrophy (Parry-Romberg syndrome) and LSCS actually represent different spectra of the same disease.

Tags: coup-de-sabre, facial-atrophy, linear-scleroderma, neurological-complications, nih
Organization: U.S. Department of Health & Human Services
Timed sequential chemotherapy with concomitant Granulocyte Colony-Stimulating Factor for high-risk acute myelogenous leukemia: a single arm clinical trial

Background
          The timed-sequential chemotherapy regimen consisting of etoposide, mitoxantrone and cytarabine (EMA) is an effective therapy for relapsed or refractory acute myelogenous leukemia (AML). We postulated that granulocyte colony-stimulating factor (G-CSF) might enhance the cytotoxicity of EMA by increasing the proportion of leukemic blasts in S-phase. We added G-CSF to EMA (EMA-G) for therapy of advanced high-risk AML patients.
        
        
          Methods
          High-risk AML was defined as refractory, relapsed or secondary to either an antecedent hematologic disorder or exposure to cytotoxic agents. The patients were treated with one course of EMA-G consisting of mitoxantrone and cytarabine on days 1–3, and etoposide and cytarabine on days 8–10. G-CSF was started on day 4 and continued until absolute neutrophil count recovered.
        
        
          Results
          Thirty patients were enrolled. The median age was 51 years (range, 25–75). Seventeen (61%) patients had unfavorable cytogenetic karyotypes. Twenty (69%) patients had secondary AML. Ten (34%) had relapsed disease. Four (14%) had refractory AML. Three (10%) patients died from febrile neutropenia and sepsis. Major non-hematologic toxicity included hyperbilirubimenia, renal insufficiency, mucositis, diarrhea, nausea and vomiting, skin rash. A complete remission was achieved in 13 (46%) patients. Median overall survival was 9 months (range, 0.5–66). Median relapse-free survival (RFS) for those who had a CR was 3 months (range, 0.5–63) with RFS censored at the time of allogeneic bone marrow transplantation or peripheral stem cell transplantation for 6 of the patients.
        
        
          Conclusions
          EMA-G is a safe and efficacious option for induction chemotherapy in advanced, high-risk AML patients. The activity of EMA may be increased if applied in patients with less advanced disease.

Tags: acute-myelogenous-leukemia, clinical-trial, ema-g-chemotherapy, g-csf-therapy, nih
Organization: U.S. Department of Health & Human Services
Compound 528587: tert-Butyl(dimethyl)silyl stearate

Chemical compound data from PubChem database. IUPAC Name: [tert-butyl(dimethyl)silyl] octadecanoate. Molecular Formula: C24H50O2Si. Molecular Weight: 398.7. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Expression of nm23-H1 gene product in esophageal squamous cell carcinoma and its association with vessel invasion and survival

Background
          We assessed the nm23-H1 gene product expression and its relationship with lymphatic and blood vessel invasion in patients with esophageal squamous cell carcinoma.
        
        
          Methods
          Formalin-fixed and paraffin-embedded tissue sections from 45 patients who were treated surgically were used in this study. Pathologists graded lymphatic and blood vessel invasion in each of the tissue samples. Expression of nm23-Hl gene product was determined using a specific monoclonal antibody.
        
        
          Results
          Expression of nm23-H1 gene product was present in 17 (37.8%) cases. We found an inverse correlation between nm23-H1 gene product expression and lymphatic vessel invasion, whereas no correlation between nm23-H1 gene product expression and blood vessel invasion. Overall survival rate was not different between nm23-H1 gene product positive and negative patients (p = 0.21). However, reduced expression of nm23-H1 gene product was associated with shorter overall survival in patients with involved lymph nodes (p < 0.05), but not in patients without involved lymph nodes (p = 0.87).
        
        
          Conclusions
          In patients with esophageal squamous cell carcinoma, there appears to be an inverse relationship between nm23-H1 gene product expression and lymphatic vessel invasion. Furthermore, nm23-H1 gene product expression might be a prognostic marker in patients with involved lymph nodes. Our data does not demonstrate any correlation between nm23-H1 gene product expression and blood vessel invasion.

Tags: esophageal-cancer, nih, nm23-h1-expression, survival-analysis, vessel-invasion
Organization: U.S. Department of Health & Human Services