AndreaBozzo/ceres-open-data-index huggingface dataset:
The significance of opthalmologic evaluation in the early diagnosis of inborn errors of metabolism: the Cretan experience

Background
          The Inborn Errors of Metabolism (IEM) are far from the rare systemic diseases that mainly affect the neural tissue. There are very few written reports on ocular findings in subjects with IEM, thus it was interesting to study the frequency of ocular findings in the studied population and explore their contribution to the early diagnosis of IEM.
        
        
          Methods
          Our study involved the evaluation of IEM suspected cases, which had been identified in a rural population in Crete, Greece. Over a period of 3 years, 125 patients, who fulfilled the inclusion criteria of this study, were examined. Analytical physical examination, detailed laboratory investigation as well as a thorough ocular examination were made.
        
        
          Results
          A diagnosis of IEM was established in 23 of the 125 patients (18.4%). Ten (43.5%) of the diagnosed IEM had ocular findings, while 8 of them (34.8%) had findings which were specific for the diagnosed diseases. One patient diagnosed with glycogenosis type 1b presented a rare finding. Of the 102 non-diagnosed patients, 53 (51.96 %) presented various ophthalmic findings, some of which could be related to a metabolic disease and therefore may be very helpful in the future.
        
        
          Conclusions
          The ocular investigation can be extremely useful for raising the suspicion and the establishment of an early diagnosis of IEM. It could also add new findings related to these diseases. The early management of the ocular symptoms can improve the quality of life to these patients.

Tags: cretan-population, inborn-metabolism-errors, nih, ocular-manifestations, ophthalmologic-evaluation
Organization: U.S. Department of Health & Human Services
NSDUH 2024 Field Interviewer Manual

This detailed manual was used as a training guide for the Field Interviewers (FIs) who conducted the in-person 2023 National Survey on Drug Use and Health (NSDUH). It covers the information presented at the intensive training for new FIs. Although it is written for NSDUH FIs, researchers may find it helpful for learning about data collection challenges that could affect data quality. It also may be helpful for those designing their own field operations.The manual includes:An introduction to the survey;A guide to what is expected of FIs;FI instructions for locating sample dwelling units, contacting residents, obtaining participation, conducting the screening and interview, documenting their experiences;Quality control and administrative procedures for FIs; andCopies of materials that were mailed or given to respondents.

Tags: data-collection, mental-health, samhsa, substance-use, survey-methodology
Organization: U.S. Department of Health & Human Services
2012 State Profile - Kentucky

This is a National Survey of Substance Abuse Treatment Services (N-SSATS) annual report showing the state profile for Kentucky in 2012. N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 States, the District of Columbia, and other U.S. jurisdictions.

Tags: kentucky, n-ssats, samhsa, substance-abuse-treatment, survey
Organization: U.S. Department of Health & Human Services
Capacity Building Center for States Final Evaluation Report: Fiscal Years 2015–2019: Executive Summary

This executive summary presents findings from an evaluation of the services delivered by the Capacity Building Center for States, which is funded by the Children’s Bureau, from fiscal years 2015 through 2019.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: assessment, fiscal, policy, real, time
Organization: U.S. Department of Health & Human Services
Preparing to Say Goodbye to Your Vendor

This webinar, sponsored by the Children’s Bureau’s Division of State Systems, addresses transition planning for the migration of powers, duties, tasks, and activities from the Statewide Automated Child Welfare Information System implementation vendor to state ownership and management as an active project ends. Anne Hunt (Washington) and Linda Holland and Deepak Gupta (New Jersey) offer advice for promoting a smooth and transparent transition, and describe their own states’ success with knowledge transfer.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: child, guidance, policy, scope, state
Organization: U.S. Department of Health & Human Services
Compound 527380: 20-Methyl-dotriacontyl cyanide

Chemical compound data from PubChem database. IUPAC Name: 21-methyltritriacontanenitrile. Molecular Formula: C34H67N. Molecular Weight: 489.9. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Increasing the Impact of Community Organizations

This Child Welfare Information Gateway podcast is available on Apple Podcasts
  
  

, GooglePlay
  
  

, Spotify
  
  

, Stitcher
  
  

, SoundCloud
  
  

, and the Child Welfare Information Gateway
  
  

 website. Subscribe to receive new episodes as they are released.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: child, podcast, service, social, welfare
Organization: U.S. Department of Health & Human Services
2010 CMHS Uniform Reporting System Output Tables

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2010. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-program, community-mental-health, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
2011 State Profile — Rhode Island

This is a National Survey of Substance Abuse Treatment Services (N-SSATS) data table showing state profiles for Rhode Island in 2011. N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 States, the District of Columbia, and other U.S. jurisdictions.

Tags: n-ssats, rhode-island, samhsa, substance-abuse-treatment, treatment-facilities
Organization: U.S. Department of Health & Human Services
2023 Uniform Reporting System (URS) Table For Mississippi

This is the 2023 Uniform Reporting System (URS) Output Tables for Mississippi. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-program, mental-health-services, national-outcome-measures, samhsa, state-mental-health
Organization: U.S. Department of Health & Human Services
Possible attenuation of the G2 DNA damage cell cycle checkpoint in HeLa cells by extremely low frequency (ELF) electromagnetic fields

Background
          The issue remains unresolved as to whether low frequency magnetic fields can affect cell behaviour, with the possibility that they may be in part responsible for the increased incidence of leukaemia in parts of the population exposed to them.
        
        
          Methods
          Combined treatment of HeLa cells with gamma-irradiation (1, 3 and 5 Grays) and extra low frequency magnetic fields of ~50 Hz was carried out under rigorously controlled conditions.
        
        
          Results
          Synchronised cells progressing from S-phase arrived at mitosis on average marginally ahead of irradiation controls not exposed to ELF. In no instance out of a total of twenty separate experiments did this "double-insult" further delay entry of cells into mitosis, as had been anticipated.
        
        
          Conclusion
          This apparently "non-genotoxic" agent (ELF) appears to be capable of affecting cells that would normally arrest for longer in G2, suggesting a weakening of the stringency of the late cycle (G2) checkpoint.

Tags: cell-cycle-checkpoint, dna-damage, elf-magnetic-fields, hela-cells, nih
Organization: U.S. Department of Health & Human Services
Acyclovir for treating varicella in otherwise healthy children and adolescents: a systematic review of randomised controlled trials

Background
          Acyclovir has the potential to shorten the course of chickenpox which may result in reduced costs and morbidity. We conducted a systematic review of randomised controlled trials that evaluated acyclovir for the treatment of chickenpox in otherwise healthy children.
        
        
          Methods
          MEDLINE, EMBASE, and the Cochrane Library were searched. The reference lists of relevant articles were examined and primary authors and Glaxo Wellcome were contacted to identify additional trials. Two reviewers independently screened studies for inclusion, assessed study quality using the Jadad scale and allocation concealment, and extracted data. Continuous data were converted to a weighted mean difference (WMD). Overall estimates were not calculated due to differences in the age groups studied.
        
        
          Results
          Three studies were included. Methodological quality was 3 (n = 2) and 4 (n = 1) on the Jadad scale. Acyclovir was associated with a significant reduction in the number of days with fever, from -1.0 (95% CI -1.5,-0.5) to -1.3 (95% CI -2.0,-0.6). Results were inconsistent with respect to the number of days to no new lesions, the maximum number of lesions and relief of pruritis. There were no clinically important differences between acyclovir and placebo with respect to complications or adverse effects.
        
        
          Conclusion
          Acyclovir appears to be effective in reducing the number of days with fever among otherwise healthy children with chickenpox. The results were inconsistent with respect to the number of days to no new lesions, the maximum number of lesions and the relief of itchiness. The clinical importance of acyclovir treatment in otherwise healthy children remains controversial.

Tags: acyclovir-treatment, nih, pediatric-infectious-disease, randomized-controlled-trial, varicella-chickenpox
Organization: U.S. Department of Health & Human Services
Compound 527250: 1-Methyl-4-(6-methylhept-4-en-2-yl)benzene

Chemical compound data from PubChem database. IUPAC Name: 1-methyl-4-(6-methylhept-4-en-2-yl)benzene. Molecular Formula: C15H22. Molecular Weight: 202.33. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2011 CMHS Uniform Reporting System (URS) Output Tables for Alabama

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2011. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, evidence-based-practices, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Trends in Smokeless Tobacco Use and Initiation: 2002 to 2014

This report examines trends in past month smokeless tobacco use among people aged 12 or older based on the 2002 to 2014 National Survey on Drug Use and Health (NSDUH) data.

Tags: nsduh-data, samhsa, smokeless-tobacco, substance-use, tobacco-use-trends
Organization: U.S. Department of Health & Human Services
Atrial natriuretic peptide infusion and nitric oxide inhalation in patients with acute respiratory distress syndrome

Aim:
          To study the effects of infusion of atrial natriuretic peptide (ANP) versus the inhalation of nitric oxide (NO) in patients with an early acute respiratory distress syndrome (ARDS).
        
        
          Methods:
          Ten patients with severe ARDS were studied in a crossover study design, within 72 hours after starting mechanical ventilation. We studied the effects of ANP infusion (10 ng/kg/min for 1 hour) and of inhalation of NO (20 ppm for 1 hour) on hemodynamic and respiratory patient parameters, as well as the effects on plasma levels of ANP, guanosine 3',5'-cyclic monophosphate, nitrate and endothelin-1.
        
        
          Results:
          Despite an approximate 50% increase in mixed venous ANP plasma concentration (from 86 ± 21 to 123 ± 33 ng/l, P < 0.05) during ANP infusion, there were no changes in mean pulmonary artery pressure, pulmonary vascular resistance index, extravascular lung water index, or in pulmonary gas exchange. NO inhalation, in contrast, lowered mean pulmonary artery pressure (from 26 ± 1.9 to 23.9 ± 1.7 mmHg, P < 0.01), pulmonary vascular resistance index (from 314 ± 37 to 273 ± 32 dynes/cm5/m2, P < 0.05) and central venous pressure (from 8.2 ± 1.2 to 7.3 ± 1.1 mmHg, P < 0.02). Furthermore, NO inhalation improved pulmonary gas exchange, reflected by a decrease in alveolar-arterial oxygen gradient (from 41.9 ± 3.9 to 40.4 ± 3.6 kPa, P < 0.05), a small increase in oxygenation (PaO2/FiO2 from 17.7 ± 1.4 to 19.7 ± 1.1 kPa, P = 0.07) and a small decrease in venous admixture (Qs/Qt from 35.7 ± 2.0 to 32.8 ± 2.7%, P = 0.11).
        
        
          Conclusion:
          This study shows that, in contrast to NO inhalation, infusion of ANP neither improves oxygenation nor attenuates pulmonary hypertension or pulmonary edema in patients with severe ARDS.

Tags: anp-infusion, ards-patients, nih, nitric-oxide, respiratory-parameters
Organization: U.S. Department of Health & Human Services
Compound 525055: 4-Chlorodecane

Chemical compound data from PubChem database. IUPAC Name: 4-chlorodecane. Molecular Formula: C10H21Cl. Molecular Weight: 176.72. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 528440: 1-Decene, 6-methyl

Chemical compound data from PubChem database. IUPAC Name: 6-methyldec-1-ene. Molecular Formula: C11H22. Molecular Weight: 154.29. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2011: National Estimates of Drug-Related Emergency Department Visits

This publication presents national estimates of drug-related visits to hospital emergency departments (EDs) for  2011, based on data from the Drug Abuse Warning Network (DAWN). Also presented are comparisons of 2011 estimates with those for 2004, 2009 and 2010.  Chapter topics include overall drug misuse and abuse, illicit drugs, alcohol (drugs and alcohol taken together, underage drinking), nonmedical use of pharmaceuticals, drug-related suicide attempts, seeking detox services, adverse reactions to pharmaceuticals and accidental ingestion of drugs.

Tags: drug-overdose, drug-related-ed-visits, emergency-department, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
Compound 525071: 1,9-Nonanediol, dibutanoate

Chemical compound data from PubChem database. IUPAC Name: 9-butanoyloxynonyl butanoate. Molecular Formula: C17H32O4. Molecular Weight: 300.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2012 State Profile - Iowa

This is a National Survey of Substance Abuse Treatment Services (N-SSATS) annual report showing the state profile for Iowa in 2012. N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 States, the District of Columbia, and other U.S. jurisdictions.

Tags: alcohol-abuse, iowa, samhsa, substance-abuse, treatment-facilities
Organization: U.S. Department of Health & Human Services
The society of genes: networks of functional links between genes from comparative genomics

Comparative genomics provides at least three methods for identifying functional links between genes: examination of phylogenetic distributions, analysis of conserved proximity and observations of fusions of genes into a multidomain gene in another organism. We show that the functional networks obtained by applying these methods have different topologies and that the information they provide is largely additive. In particular, the combined networks of functional links contain an average of 57% of an organism's complete genetic complement, uncover substantial portions of known pathways, and suggest the function of previously unannotated genes. In addition, the combined networks are qualitatively different from the networks obtained using individual methods.

Tags: comparative-genomics, functional-links, gene-networks, nih, phylogenetic-distribution
Organization: U.S. Department of Health & Human Services
Compound 525500: 1-Butanethiol, 4-(methylthio)-

Chemical compound data from PubChem database. IUPAC Name: 4-methylsulfanylbutane-1-thiol. Molecular Formula: C5H12S2. Molecular Weight: 136.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Surfactant protein-D and pulmonary host defense

Surfactant protein-D (SP-D) participates in the innate response to inhaled microorganisms and organic antigens, and contributes to immune and inflammatory regulation within the lung. SP-D is synthesized and secreted by alveolar and bronchiolar epithelial cells, but is also expressed by epithelial cells lining various exocrine ducts and the mucosa of the gastrointestinal and genitourinary tracts. SP-D, a collagenous calcium-dependent lectin (or collectin), binds to surface glycoconjugates expressed by a wide variety of microorganisms, and to oligosaccharides associated with the surface of various complex organic antigens. SP-D also specifically interacts with glycoconjugates and other molecules expressed on the surface of macrophages, neutrophils, and lymphocytes. In addition, SP-D binds to specific surfactant-associated lipids and can influence the organization of lipid mixtures containing phosphatidylinositol in vitro. Consistent with these diverse in vitro activities is the observation that SP-D-deficient transgenic mice show abnormal accumulations of surfactant lipids, and respond abnormally to challenge with respiratory viruses and bacterial lipopolysaccharides. The phenotype of macrophages isolated from the lungs of SP-D-deficient mice is altered, and there is circumstantial evidence that abnormal oxidant metabolism and/or increased metalloproteinase expression contributes to the development of emphysema. The expression of SP-D is increased in response to many forms of lung injury, and deficient accumulation of appropriately oligomerized SP-D might contribute to the pathogenesis of a variety of human lung diseases.

Tags: innate-immunity, lung-inflammation, nih, pulmonary-defense, surfactant-protein-d
Organization: U.S. Department of Health & Human Services
Clinical significance of cardiovascular dysmetabolic syndrome

Although diabetes mellitus is predominantly a metabolic disorder, recent data suggest that it is as much a vascular disorder. Cardiovascular complications are the leading cause of death and disability in patients with diabetes mellitus. A number of recent reports have emphasized that many patients already have atherosclerosis in progression by the time they are diagnosed with clinical evidence of diabetes mellitus. The increased risk of atherosclerosis and cardiovascular complications in diabetic patients is related to the frequently associated dyslipidemia, hypertension, hyperglycemia, hyperinsulinemia, and endothelial dysfunction. The evolving knowledge regarding the variety of metabolic, hormonal, and hemodynamic abnormalities in patients with diabetes mellitus has led to efforts designed for early identification of individuals at risk of subsequent disease. It has been suggested that insulin resistance, the key abnormality in type II diabetes, often precedes clinical features of diabetes by 5–6 years. Careful attention to the criteria described for the cardiovascular dysmetabolic syndrome should help identify those at risk at an early stage. The application of nonpharmacologic as well as newer emerging pharmacologic therapies can have beneficial effects in individuals with cardiovascular dysmetabolic syndrome and/or diabetes mellitus by improving insulin sensitivity and related abnormalities. Early identification and implementation of appropriate therapeutic strategies would be necessary to contain the emerging new epidemic of cardiovascular disease related to diabetes.

Tags: cardiovascular-disease, diabetes-mellitus, insulin-resistance, metabolic-syndrome, nih
Organization: U.S. Department of Health & Human Services