AndreaBozzo/ceres-open-data-index huggingface dataset:
2019 Uniform Reporting System (URS) Table for New York

These are the 2019 Uniform Reporting System (URS) Output Tables for New York. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-program, community-mental-health, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
2019 Uniform Reporting System (URS) Table for Oregon

These are the 2019 Uniform Reporting System (URS) Output Tables for Oregon. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: mental-health-services, noms-measures, oregon-mental-health, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
New Hampshire: 2011-2012 NSDUH

This report presents New Hampshire\'s estimates for 25 measures of substance use and mental health based on the combined 2011 and 2012 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided by State and for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: mental-health, nh-nsduh, samhsa, serious-mental-illness, substance-use
Organization: U.S. Department of Health & Human Services
Weight-modification trials in older adults: what should the outcome measure be?

Background
          Overweight older adults are often counseled to lose weight, even though there is little evidence of excess mortality in that age group. Overweight and underweight may be more associated with health status than with mortality, but few clinical trials of any kind have been based on maximizing years of healthy life (YHL), as opposed to years of life (YOL).
        
        
          Objective
          This paper examines the relationship of body mass index (BMI) to both YHL and YOL. Results were used to determine whether clinical trials of weight-modification based on improving YHL would be more powerful than studies based on survival.
        
        
          Design
          We used data from a cohort of 4,878 non-smoking men and women aged 65–100 at baseline (mean age 73) and followed 7 years. We estimated mean YHL and YOL in four categories of BMI: underweight, normal, overweight, and obese.
        
        
          Results
          Subjects averaged 6.3 YOL and 4.6 YHL of a possible 7 years. Both measures were higher for women and whites. For men, none of the BMI groups was significantly different from the normal group on either YOL or YHL. For women, the obese had significantly lower YHL (but not YOL) than the normals, and the underweight had significantly lower YOL and YHL. The overweight group was not significantly different from the normal group on either measure.
        
        
          Conclusions
          Clinical trials of weight loss interventions for obese older women would require fewer participants if YHL rather than YOL was the outcome measure. Interventions for obese men or for the merely overweight are not likely to achieve differences in either YOL or YHL. Evaluations of interventions for the underweight (which would presumably address the causes of their low weight) may be conducted efficiently using either outcome measure.

Tags: bmi-older-adults, geriatric-health, healthy-life-years, nih, weight-modification
Organization: U.S. Department of Health & Human Services
Florida 2016 Potential Areas for Addressing Service Gaps for Opioid Treatment

The purpose of the medication-assisted treatment (MAT) facility maps is to identify areas on a state-by-state basis that may be potentially underserved by existing treatment facilities. The maps are created with a methodology that seeks to include the highest potential need areas from individual counties so that county-level stakeholders are also informed. The maps are meant to be used as a tool for policy makers to determine potentially underserved areas—not as a definitive representation of these areas.

Tags: florida-health, medication-assisted-treatment, opioid-treatment, samhsa, service-gap-analysis
Organization: U.S. Department of Health & Human Services
Compound 525043: D-Mannitol, 1,2,3,4,5,6-hexakis-O-(trimethylsilyl)-

Chemical compound data from PubChem database. IUPAC Name: trimethyl-[(2S,3S,4S,5S)-1,2,4,5,6-pentakis(trimethylsilyloxy)hexan-3-yl]oxysilane. Molecular Formula: C24H62O6Si6. Molecular Weight: 615.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 525160: Heptaethylene glycol, diacetate

Chemical compound data from PubChem database. IUPAC Name: 2-[2-[2-[2-[2-[2-(2-acetyloxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl acetate. Molecular Formula: C18H34O10. Molecular Weight: 410.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2023 Uniform Reporting System (URS) Table For New York

This is the 2023 Uniform Reporting System (URS) Output Tables for New York. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-program, evidence-based-practices, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Compound 527382: 20-Methyl-triacontyl cyanide

Chemical compound data from PubChem database. IUPAC Name: 21-methylhentriacontanenitrile. Molecular Formula: C32H63N. Molecular Weight: 461.8. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Angiotensin II induced inflammation in the kidney and in the heart of double transgenic rats

Background
          We are investigating a double transgenic rat (dTGR) model, in which rats transgenic for the human angiotensinogen and renin genes are crossed. These rats develop moderately severe hypertension but die of end-organ cardiac and renal damage by week 7. The heart shows necrosis and fibrosis, whereas the kidneys resemble the hemolytic-uremic syndrome vasculopathy. Surface adhesion molecules (ICAM-1 and VCAM-1) are expressed early on the endothelium, while the corresponding ligands are found on circulating leukocytes. Leukocyte infiltration in the vascular wall accompanies PAI-1, MCP-1, iNOS and Tissue Factor expression. Furthermore we show evidence that Ang II causes the upregulation of NF-kB in our model.
        
        
          Methods
          We started PDTC-treatment on four weeks old dTGR (200 mg/kg sc) and age-matched SD rats.. Blood-pressure- and albuminuria- measurements were monitored during the treatement period (four weeks). The seven weeks old animals were killed, hearts and kidneys were isolated and used for immunohistochemical-and electromobility shift assay analsis.
        
        
          Results
          Chronic treatment with the antioxidant PDTC decreased blood pressure (162 ± 8 vs. 190 ± 7 mm Hg, p = 0.02). Cardiac hypertrophy index was significantly reduced (4.90 ± 0.1 vs. 5.77 ± 0.1 mg/g, p < 0.001) compared to dTGR. PDTC reduced 24 h albuminuria by 85 % (2.7 ± 0.5 vs. 18.0 ± 3.4 mg/d, p < 0.001) and prevented death significantly. Vascular injury was ameliorated in small renal and cardiac vessels. PDTC inhibited NF-κB binding activity in heart and kidney. Immunohistochemical analysis shows increased expression of the p65 NF-κB subunit in the endothelium, smooth muscles cells of damaged small vessels, infiltrated cells, glomeruli, tubuli and collecting ducts of dTGR. PDTC markedly reduced the immunoreactivity of p65.
        
        
          Conclusion
          Our data show that inhibition of NF-κB by PDTC markedly reduces inflammation, iNOS expression in the dTGR most likely leading to decreased cytotoxicity, and cell proliferation. Thus, NF-κB activation plays an important role in ANG II-induced end-organ damage.

Tags: angiotensin-ii, cardiac-damage, kidney-inflammation, nih, transgenic-rats
Organization: U.S. Department of Health & Human Services
A glutamine-amidotransferase-like protein modulates FixT anti-kinase activity in

Background
          Nitrogen fixation gene expression in Sinorhizobium meliloti, the alfalfa symbiont, depends on a cascade of regulation that involves both positive and negative control. On top of the cascade, the two-component regulatory system FixLJ is activated under the microoxic conditions of the nodule. In addition, activity of the FixLJ system is inhibited by a specific anti-kinase protein, FixT. The physiological significance of this negative regulation by FixT was so far unknown.
        
        
          Results
          We have isolated by random Tn5 mutagenesis a S. meliloti mutant strain that escapes repression by FixT. Complementation test and DNA analysis revealed that inactivation of an asparagine synthetase-like gene was responsible for the phenotype of the mutant. This gene, that was named asnO, encodes a protein homologous to glutamine-dependent asparagine synthetases. The asnO gene did not appear to affect asparagine biosynthesis and may instead serve a regulatory function in S. meliloti. We provide evidence that asnO is active during symbiosis .
        
        
          Conclusions
          Isolation of the asnO mutant argues for the existence of a physiological regulation associated with fixT and makes it unlikely that fixT serves a mere homeostatic function in S. meliloti. Our data suggest that asnO might control activity of the FixT protein, in a way that remains to be elucidated. A proposed role for asnO might be to couple nitrogen fixation gene expression in S. meliloti to the nitrogen needs of the cells.

Tags: fixlj-system, gene-expression, nih, nitrogen-fixation, sinorhizobium-meliloti
Organization: U.S. Department of Health & Human Services
4.17a Facilities employing specific practices as part of their standard operating procedures, by facility operation and primary focus of facility: 2011. Number

This is a National Survey of Substance Abuse Treatment Services (N-SSATS) data table showing facilities employing specific practices as part of their standard operating procedures, by facility operation and primary focus of facility in 2011. N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 States, the District of Columbia, and other U.S. jurisdictions.

Tags: behavioral-health, facility-practices, n-ssats, samhsa, substance-abuse-treatment
Organization: U.S. Department of Health & Human Services
Permutation-validated principal components analysis of microarray data

Background
          In microarray data analysis, the comparison of gene-expression profiles with respect to different conditions and the selection of biologically interesting genes are crucial tasks. Multivariate statistical methods have been applied to analyze these large datasets. Less work has been published concerning the assessment of the reliability of gene-selection procedures. Here we describe a method to assess reliability in multivariate microarray data analysis using permutation-validated principal components analysis (PCA). The approach is designed for microarray data with a group structure.
        
        
          Results
          We used PCA to detect the major sources of variance underlying the hybridization conditions followed by gene selection based on PCA-derived and permutation-based test statistics. We validated our method by applying it to well characterized yeast cell-cycle data and to two datasets from our laboratory. We could describe the major sources of variance, select informative genes and visualize the relationship of genes and arrays. We observed differences in the level of the explained variance and the interpretability of the selected genes.
        
        
          Conclusions
          Combining data visualization and permutation-based gene selection, permutation-validated PCA enables one to illustrate gene-expression variance between several conditions and to select genes by taking into account the relationship of between-group to within-group variance of genes. The method can be used to extract the leading sources of variance from microarray data, to visualize relationships between genes and hybridizations and to select informative genes in a statistically reliable manner. This selection accounts for the level of reproducibility of replicates or group structure as well as gene-specific scatter. Visualization of the data can support a straightforward biological interpretation.

Tags: gene-expression, microarray-data, nih, permutation-testing, principal-components-analysis
Organization: U.S. Department of Health & Human Services
Method for non-invasively recording electrocardiograms in conscious mice

Background
          The rapid increase in the development of mouse models is resulting in a growing demand for non-invasive physiological monitoring of large quantities of mice. Accordingly, we developed a new system for recording electrocardiograms (ECGs) in conscious mice without anesthesia or implants, and created Internet-accessible software for analyzing murine ECG signals. The system includes paw-sized conductive electrodes embedded in a platform configured to record ECGs when 3 single electrodes contact 3 paws.
        
        
          Results
          With this technique we demonstrated significantly reduced heart rate variability in neonates compared to adult mice. We also demonstrated that female mice exhibit significant ECG differences in comparison to age-matched males, both at baseline and in response to β-adrenergic stimulation.
        
        
          Conclusions
          The technology we developed enables non-invasive screening of large numbers of mice for ECG changes resulting from genetic, pharmacological, or pathophysiological alterations. Data we obtained non-invasively are not only consistent with what have been reported using invasive and expensive methods, but also demonstrate new findings regarding gender-dependent and age-dependent variations in ECGs in mice.

Tags: electrocardiography, heart-rate-variability, mouse-ecg, nih, non-invasive-monitoring
Organization: U.S. Department of Health & Human Services
The plasma membrane carbonic anhydrase in murine hepatocytes identified as isozyme XIV

Background
          Biochemical and histochemical studies have both previously indicated plasma membrane-associated carbonic anhydrase (CA) activity in hepatocytes which has been assumed to be CA IV. However, immunohistochemical data did not support this assignment. Recent northern blotting results indicated the presence of mRNA for the most recently discovered membrane-bound CA isozyme, CA XIV, in the liver. The present study was designed to examine whether CA XIV could contribute to the CA activity described in the hepatocytes.
        
        
          Methods
          Tissue samples from mouse liver were subjected to immunohistochemical staining using the antibodies raised against recombinant mouse CA XIV and CA IV. RT-PCR and western blotting were also performed for CA XIV.
        
        
          Results
          A strong immunofluorescent signal was observed in the plasma membrane of mouse hepatocytes. Although CA XIV was expressed on both the apical and basolateral surfaces, the staining was more prominent at the apical (canalicular) membrane domain. The expression of CA XIV in the liver was confirmed by RT-PCR and western blotting.
        
        
          Conclusions
          The presence of CA XIV in the hepatocyte plasma membrane places this novel enzyme at a strategic site to control pH regulation and ion transport between the hepatocytes, sinusoids and bile canaliculi.

Tags: carbonic-anhydrase, enzyme-isozyme, hepatocytes, nih, plasma-membrane
Organization: U.S. Department of Health & Human Services
A Day in the Life of College Students Aged 18 to 22: Substance Use Facts

This short report uses 2011 to 2014 National Survey on Drug Use and Health (NSDUH) to assess substance initiation and substance use among part-time and full-time college students aged 18 to 22.

Tags: college-students, nsduh-data, samhsa, substance-use, young-adults
Organization: U.S. Department of Health & Human Services
2015 CMHS Uniform Reporting System (URS) Table for Ohio

2015 Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for Ohio.  The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant, mental-health-services, ohio, outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Compound 528383: Benzaldehyde, tetrachloro-2-hydroxy

Chemical compound data from PubChem database. IUPAC Name: 2,3,4,5-tetrachloro-6-hydroxybenzaldehyde. Molecular Formula: C7H2Cl4O2. Molecular Weight: 259.9. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 525657: p-Bromobenzylidene-(3-methylphenyl)-amine

Chemical compound data from PubChem database. IUPAC Name: 1-(4-bromophenyl)-N-(3-methylphenyl)methanimine. Molecular Formula: C14H12BrN. Molecular Weight: 274.15. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Access to and Outcomes of Substance Use Disorder Treatment Services Provided to Adolescents and Young Adults

This profile presents data collected from January 21, 2023, through September 30, 2024, from several of SAMHSA’s discretionary grant programs that have supported substance use disorder treatment services for adolescents and young adults.

Tags: adolescent-treatment, samhsa, substance-use-disorder, treatment-outcomes, young-adults
Organization: U.S. Department of Health & Human Services
Compound 525112: 2,3-Dichloropropyl octanoate

Chemical compound data from PubChem database. IUPAC Name: 2,3-dichloropropyl octanoate. Molecular Formula: C11H20Cl2O2. Molecular Weight: 255.18. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2021 Uniform Reporting System (URS) Table For Illinois

This is the 2021 Uniform Reporting System (URS) Output Tables for Illinois. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: illinois, mental-health-services, national-outcome-measures, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
Compound 528427: Flavanone, 5,7-dihydroxy-4'-methoxy, bis-TMS

Chemical compound data from PubChem database. IUPAC Name: 2-(4-methoxyphenyl)-5,7-bis(trimethylsilyloxy)-2,3-dihydrochromen-4-one. Molecular Formula: C22H30O5Si2. Molecular Weight: 430.6. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Oral health behavior patterns among Tanzanian university students: a repeat cross-sectional survey

Purpose
          This study examines oral health behavioral trends and the development of sociodemographic differences in oral health behaviors among Tanzanian students between 1999 and 2000.
        
        
          Methods
          The population targeted was students attending the Muhimbili University College of Health Sciences (MUCHS) at the University of Dar es Salaam (UDSM), Dar es Salaam, Tanzania. Cross-sectional surveys were conducted and a total of 635 and 981 students, respectively, completed questionnaires in 1999 and 2001.
        
        
          Results
          Cross-tabulation analyses revealed that in 1999, the rates of abstinence from tobacco use, and of soft drink consumption, regular dental checkups, and intake of chocolate/candy were 84%, 51%, 48%, and 12%, respectively, among students of urban origin and 83%, 29%, 37%, and 5% among their rural counterparts. The corresponding rates in 2001 were 87%, 56%, 50%, and 9% among urban students and 84%, 44%, 38%, and 4% among rural ones. Multiple logistic regression analyses controlling for sex, age, place of origin, educational level, year of survey, and their interaction terms revealed a significant increase in the rate of soft drink consumption, implementation of oral hygiene measures, and abstinence from tobacco use between 1999 and 2001. Social inequalities observed in 1999, with urban students being more likely than their rural counterparts to take soft drinks and go for regular dental checkups, had leveled off by 2001.
        
        
          Conclusion
          This study provides initial evidence of oral health behavioral trends, that may be utilized in the planning of preventive programs among university students in Tanzania.

Tags: health-behavior, nih, oral-health, student-health, tanzania
Organization: U.S. Department of Health & Human Services
Compound 528378: 2,3,5-Trichloro-4-hydroxybenzaldehyde

Chemical compound data from PubChem database. IUPAC Name: 2,3,5-trichloro-4-hydroxybenzaldehyde. Molecular Formula: C7H3Cl3O2. Molecular Weight: 225.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services