AndreaBozzo/ceres-open-data-index huggingface dataset:
Compound 525502: 6-Methyl-3-thiaheptane

Chemical compound data from PubChem database. IUPAC Name: 1-ethylsulfanyl-3-methylbutane. Molecular Formula: C7H16S. Molecular Weight: 132.27. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Seed germination, phenology, and antiedematogenic activity of

Background
          Peperomia pellucida is popularly known as coraçãozinho in the Brazilian northeast and is used in the treatment of abscesses, furuncles, and conjunctivitis. Our work aimed to determine the term of the development stages and the species cycle in the four seasons of the year (complete development, beginning of bloom, complete bloom, and seed set), verifying the plant's therapeutic profile during the four distinct development phases in order to detect differences in its potency. Pharmacological tests were performed to observe the anti-inflammatory activity.
        
        
          Results
          Phenological observations were accessed for a 12 month-period, from the Brazilian summer of 1999/2000 to fall 2000. On average the plantules' emergence occurred 15 days after seeding. All plantules grew in a similar manner up to 25 days after transplantation in all seasons. Starting on the 25th day, we observed faster growth during spring, with plants reaching a height of about 60 cm after 100 days of transplantation, unlike other seasons, in which plants reached heights of 40, 40, and 35 cm during winter, summer, and fall, respectively. The P. pellucida aqueous extract showed significant anti-inflammatory activity during phenophases 1 and 2 of winter and spring. Depending on the plant's phenophase there was variation in the potency of edema inhibition.
        
        
          Conclusion
          P. pellucida has a phenological cycle of approximately 100 days. It is recommended that the P. pellucida aqueous extract is used as an antiedematogenic only during phenophases 1 and 2 of winter and spring.

Tags: anti-inflammatory-activity, medicinal-plants, nih, peperomia-pellucida, phenology
Organization: U.S. Department of Health & Human Services
Comparison of 2002-2003 and 2010-2011 prevalence estimates for persons aged 12 or older, 12 to 17, 18 to 25, and 26 or older

This report presents trends of estimates for measures of substance use and mental health based on the combined 2002 and 2003 and the combined 2010 and 2011 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: mental-health, nsduh-survey, prevalence-estimates, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Comparison of an immortalized human corneal epithelial cell line with Vero cells in the isolation of Herpes simplex virus-1 for the laboratory diagnosis of Herpes simplex keratitis

Background
          Herpes simplex keratitis (HSK) is a sight threatening ocular infection often requiring a specific and prompt laboratory diagnosis. Isolation of Herpes simplex virus (HSV-1) in culture provides the most reliable and specific method and is considered as the "Gold Standard" in the laboratory diagnosis of HSK in spite of its low sensitivity. Using "cell lines of corneal origin" for virus isolation may be beneficial under such circumstances, since these cells have been shown to be excellent substrates for the growth of HSV-1 isolated from the cornea. We report a comparative study of a novel human corneal epithelial cell line (HCE) and the Vero cell line in the isolation of HSV-1 from corneal scrapings employing a shell vial assay.
        
        
          Methods
          Corneal scrapings were obtained from 17 patients with a clinical diagnosis of HSK. All the cases were confirmed by virological investigations (PCR and viral antigen detection positive, n = 15, PCR positive, n = 1, Viral antigen positive, n = 1). Scrapings obtained from 10 patients with infectious keratitis of non-viral origin were included as controls. All the scrapings were simultaneously inoculated into shell vials of HCE and Vero cells. Cultures were terminated at 24 h post-infection. Isolation of HSV-1 was confirmed using an indirect immunofluorescence/ immunoperoxidase assay.
        
        
          Results
          Virus could be isolated using both or either of the cell lines in 10/17 (58.82%) patients with HSK. HSV-1 was isolated from 10/ 17 (58.82%) and 4/17(23.52%) specimens in HCE and Vero cells, respectively (P = 0.036). None of the controls yielded HSV-1. While all the 10 (100%) strains were isolated in HCE, Vero yielded only 4/10 (40%) strains in the shell vial culture (P = 0.014).
        
        
          Conclusions
          HCE showed a statistically significant difference in the virus isolation rate with respect to Vero cells. HCE may be an excellent alternative cell line for the isolation of HSV-1, especially from corneal scrapings, for the laboratory diagnosis of HSK.

Tags: corneal-epithelial-cells, herpes-simplex-keratitis, hsv-1-isolation, nih, vero-cells
Organization: U.S. Department of Health & Human Services
2015 CMHS Uniform Reporting System (URS) Table for Montana

2015 Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for Montana. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, montana, outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
2010 State Profile — Guam

This state profile includes data from facilities in Guam that reported to N-SSATS for the survey reference date March 31, 2010. Data were collected on the location, characteristics, services offered, and number of clients in treatment at alcohol and drug abuse treatment facilities (both public and private) in Guam. In Guam, 6 substance abuse treatment facilities were included in the 2010 N-SSATS, reporting that there were 257 clients in substance abuse treatment on March 31, 2010. The survey response rate in Guam was 100.0%.

Tags: alcohol-abuse-treatment, guam, n-ssats, samhsa, substance-abuse-treatment
Organization: U.S. Department of Health & Human Services
Apoptosis and signalling in acid sphingomyelinase deficient cells

Background
          Recent evidence suggests that the activation of a non-specific lipid scramblase during apoptosis induces the flipping of sphingomyelin from the cell surface to the cytoplasmic leaftet of the plasma membrane. Inner leaflet sphingomyelin is then cleaved to ceramide by a neutral sphingomyelinase. The production of this non-membrane forming lipid induces blebbing of the plasma membrane to aid rapid engulfment by professional phagocytes. However contrary evidence suggests that cells which are deficient in acid sphingomyelinase are defective in apoptosis signalling. This data has been interpreted as support for the activation of acid sphingomyelinase as an early signal in apoptosis.
        
        
          Hypothesis
          An alternative explanation is put forward whereby the accumulation of intracellular sphingomyelin in sphingomyelinase deficient cells leads to the formation of intracellular rafts which lead to the sequestration of important signalling molecules that are normally present on the cell surface where they perform their function.
        
        
          Testing the hypothesis
          It is expected that the subcellular distribution of important signalling molecules is altered in acid sphingomyelinase deficient cells, leading to their sequestration in late endosomes / lysosomes. Other sphingolipid storage diseases such as Niemann-Pick type C which have normal acid sphingomyelinase activity would also be expected to show the same phenotype.
        
        
          Implications of the hypothesis
          If true the hypothesis would provide a mechanism for the pathology of the sphingolipid storage diseases at the cellular level and also have implications for the role of ceramide in apoptosis.

Tags: apoptosis-signaling, ceramide-production, lipid-rafts, nih, sphingomyelinase-deficiency
Organization: U.S. Department of Health & Human Services
Differential binding of chemokines to macrophages and neutrophils in the human inflamed synovium

In chronic inflammatory foci, such as the rheumatoid joint, there is enhanced recruitment of phagocytes from the blood into the tissues. Chemokines are strongly implicated in directing the migration of these cells, although little is known regarding the chemokine receptors that could mediate their chemotaxis into the joint tissue. Therefore the objective of the study was to identify chemokine binding sites on macrophages and neutrophils within the rheumatoid synovium using radiolabeled ligand binding and in situ autoradiography. Specific binding sites for CCL3 (macrophage inflammatory protein-1α), CCL5 (RANTES), CCL2 (monocyte chemoattractant protein-1) and CXCL8 (IL-8) were demonstrated on CD68+ macrophages in the subintimal and intimal layers. The number and percentage of intimal cells that bound chemokines were greater in inflamed regions compared to noninflamed regions. The intensity of intimal binding varied between chemokines with the rank order, CCL3 > CCL5 > CCL2 > CXCL8. Neutrophils throughout the synovium bound CXCL8 but did not show any signal for binding CCL2, CCL3 or CCL5.
        Immunohistochemistry showed that both CXCR1 and CXCR2 are expressed by macrophages and neutrophils in the rheumatoid and nonrheumatoid synovia, suggesting that both of these receptors are responsible for the CXCL8 binding. The chemokine binding sites described on phagocytes may be involved in the migration of these cells into the inflamed joint.

Tags: chemokine-binding, macrophages-neutrophils, nih, rheumatoid-arthritis, synovial-inflammation
Organization: U.S. Department of Health & Human Services
Metabolic flux balance analysis and the

Background
          Genome sequencing and bioinformatics are producing detailed lists of the molecular components contained in many prokaryotic organisms. From this 'parts catalogue' of a microbial cell, in silico representations of integrated metabolic functions can be constructed and analyzed using flux balance analysis (FBA). FBA is particularly well-suited to study metabolic networks based on genomic, biochemical, and strain specific information.
        
        
          Results
          Herein, we have utilized FBA to interpret and analyze the metabolic capabilities of Escherichia coli. We have computationally mapped the metabolic capabilities of E. coli using FBA and examined the optimal utilization of the E. coli metabolic pathways as a function of environmental variables. We have used an in silico analysis to identify seven gene products of central metabolism (glycolysis, pentose phosphate pathway, TCA cycle, electron transport system) essential for aerobic growth of E. coli on glucose minimal media, and 15 gene products essential for anaerobic growth on glucose minimal media. The in silico tpi-, zwf, and pta- mutant strains were examined in more detail by mapping the capabilities of these in silico isogenic strains.
        
        
          Conclusions
          We found that computational models of E. coli metabolism based on physicochemical constraints can be used to interpret mutant behavior. These in silica results lead to a further understanding of the complex genotype-phenotype relation.
          Supplementary information:

Tags: escherichia-coli, genome-scale-modeling, metabolic-flux-analysis, metabolic-networks, nih
Organization: U.S. Department of Health & Human Services
2012-2013 NSDUH Estimated Totals by State

State-level totals and 95% confidence intervals for individuals aged 12 or older, 12 to 17, 18 to 25, 26 or older, and 18 or older are presented; also shown are totals for individuals aged 12 to 20 for two alcohol measures.

Tags: mental-health, nsduh, samhsa, state-level-data, substance-use
Organization: U.S. Department of Health & Human Services
Compound 527251: 2,4-Heptanedione, 3,5-dimethyl

Chemical compound data from PubChem database. IUPAC Name: 3,5-dimethylheptane-2,4-dione. Molecular Formula: C9H16O2. Molecular Weight: 156.22. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 527295: 1,4-Di-isopentylbenzene

Chemical compound data from PubChem database. IUPAC Name: 1,4-bis(3-methylbutyl)benzene. Molecular Formula: C16H26. Molecular Weight: 218.38. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Detroit: Drug-Related Emergency Department Visits, 2004-2011 - Adverse Reactions

Excel file with estimates, rates, relative standard errors, trends and confidence intervals, covering 2004-2011 for emergency department visits involving adverse reactions in the Detroit metropolitan area. It includes ED visits in which an adverse health consequence (e.g., side effects or an allergic reaction) resulted when taking prescription drugs, over-the-counter medications, or dietary supplements as prescribed or recommended.  This analytic category does not include drug misuse or abuse.File includes data for over 500 drugs, including illicit drugs, prescription and over-the-counter medications, dietary supplements, inhalants and alcohol.  Includes total visits, gender, age group, race/ethnicity, outcome of visit, drug combinations, number of drugs involved in visit, drug frequency, and drugs confirmed by toxicology.Additional detail is provided for illicit drugs, psychotherapeutic drugs, central nervous system (CNS) drugs, respiratory drugs and cardiovascular drugs.

Tags: adverse-drug-reactions, detroit-metro-area, emergency-department-visits, prescription-drugs, samhsa
Organization: U.S. Department of Health & Human Services
Characterization of BTBD1 and BTBD2, two similar BTB-domain-containing Kelch-like proteins that interact with Topoisomerase I

Background
          Two-hybrid screening for proteins that interact with the core domain of human topoisomerase I identified two novel proteins, BTBD1 and BTBD2, which share 80% amino acid identities.
        
        
          Results
          The interactions were confirmed by co-precipitation assays demonstrating the physical interaction of BTBD1 and BTBD2 with 100 kDa topoisomerase I from HeLa cells. Deletion mapping using two-hybrid and GST-pulldown assays demonstrated that less than the C-terminal half of BTBD1 is sufficient for binding topoisomerase I. The topoisomerase I sequences sufficient to bind BTBD2 were mapped to residues 215 to 329. BTBD2 with an epitope tag localized to cytoplasmic bodies. Using truncated versions that direct BTBD2 and TOP1 to the same cellular compartment, either the nucleus or the cytoplasm, co-localization was demonstrated in co-transfected Hela cells. The supercoil relaxation and DNA cleavage activities of topoisomerase I in vitro were affected little or none by co-incubation with BTBD2. Northern analysis revealed only a single sized mRNA for each BTBD1 and BTBD2 in all human tissues tested. Characterization of BTBD2 mRNA revealed a 255 nucleotide 90% GC-rich region predicted to encode the N-terminus. BTBD1 and BTBD2 are widely if not ubiquitously expressed in human tissues, and have two paralogs as well as putative orthologs in C. elegans and D. melanogaster.
        
        
          Conclusions
          BTBD1 and BTBD2 belong to a small family of uncharacterized proteins that appear to be specific to animals. Epitope-tagged BTBD2 localized to cytoplasmic bodies. The characterization of BTBD1 and BTBD2 and their interaction with TOP1 is underway.

Tags: btbd1, btbd1-btbd2, nih, protein-interaction, topoisomerase-i
Organization: U.S. Department of Health & Human Services
Compound 525326: Pyrazolo[1,5-d][1,2,4]triazin-3-one, 2,6,7,7-tetramethyl

Chemical compound data from PubChem database. IUPAC Name: 2,6,7,7-tetramethyl-5H-pyrazolo[1,5-d][1,2,4]triazin-4-one. Molecular Formula: C9H14N4O. Molecular Weight: 194.23. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Gender and HIV-associated pulmonary tuberculosis: presentation and outcome at one year after beginning antituberculosis treatment in Uganda

Background
          Tuberculosis is responsible for more female deaths around the earth than any other infectious disease. Reports have suggested that responses to tuberculosis may differ between men and women. We investigated gender related differences in the presentation and one year outcomes of HIV-infected adults with initial episodes of pulmonary tuberculosis in Uganda.
        
        
          Methods
          We enrolled and followed up a cohort of 105 male and 109 female HIV-infected adults on treatment for initial episodes of culture-confirmed pulmonary tuberculosis between March 1993 and March 1995. A favorable outcome was defined as being cured and alive at one year while an unfavorable outcome was not being cured or dead. Subjects were followed-up by serial medical examinations, complete blood counts, serum β2 microglobulin, CD4+ cell counts, sputum examinations, and chest x-rays.
        
        
          Results
          Male patients were older, had higher body mass indices, and lower serum β2 microglobulin levels than female patients at presentation. At one year, there was no difference between male and female patients in the likelihood of experiencing a favorable outcome (RR 1.02, 95% CI 0.89–1.17). This effect persisted after controlling for symptoms, serum β2 microglobulin, CD4+ cell count, and severity of disease on chest x-ray (OR 1.07, 95% CI 0.54–2.13) with a repeated measures model.
        
        
          Conclusions
          While differences existed between males and females with HIV-associated pulmonary tuberculosis at presentation, the outcomes at one year after the initiation of tuberculosis treatment were similar in Uganda. Women in areas with a high HIV and tuberculosis prevalence should be encouraged to present for screening at the first sign of tuberculosis symptoms.

Tags: gender-differences, hiv-tb-coinfection, nih, tuberculosis-treatment, uganda-cohort-study
Organization: U.S. Department of Health & Human Services
Tennessee AFCARS Assessment Review, 2013

This webpage includes the documentation from Tennessee's Adoption and Foster Care Analysis and Reporting System (AFCARS) assessment review for fiscal year 2013:

AFCARS Assessment Review Letter

AFCARS Assessment Review Report

Tab A - Detailed Findings

Finding Instructions

Section I

AFCARS Assessment Review Findings - General Requirement

Section II

AFCARS Assessment Review Findings - Foster Care and Adoption Elements

Section III

AFCARS Case File Summary Report

AFCARS Assessment Review Case File Findings - Foster Care and Adoption Elements

Tab B - AFCARS Improvement Plan

Improvement Plan Instruction

Section I

AFCARS Assessment Review Improvement Plan - General Requirements

Section II

AFCARS Assessment Review Improvement Plan - Foster Care and Adoption Elements

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: adoption, assessment, fiscal, foster, reporting
Organization: U.S. Department of Health & Human Services
Casework: What it Really Takes

This Child Welfare Information Gateway Podcast is available on Apple Podcasts
  
  

, GooglePlay
  
  

, Spotify
  
  

, Stitcher
  
  

, SoundCloud
  
  

, and the Child Welfare Information Gateway
  
  

 website. Subscribe to receive new episodes as they are released.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: child, podcast, service, social, welfare
Organization: U.S. Department of Health & Human Services
North Dakota (ND)

This report presents estimates for measures of substance use and mental health based on the combined 2010 and 2011 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for North Dakota for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: mental-health, north-dakota, samhsa, substance-use, survey-data
Organization: U.S. Department of Health & Human Services
Drug Abuse Warning Network (DAWN): Non-Fatal Overdoses Short Report

Drug Abuse Warning Network (DAWN) Non-Fatal Overdoses Short Report presents: (1) national estimates and characteristics of non-fatal overdose ED visits, (2) the identification of top substances involved in these visits and (3) the prevalence of polysubstance related non-fatal overdose ED visits. Additional report resources are also available in theNon-Fatal Overdoses Short Report - Companion Document.

Tags: drug-overdose-epidemiology, emergency-department-visits, non-fatal-overdoses, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
MP20, the second most abundant lens membrane protein and member of the tetraspanin superfamily, joins the list of ligands of galectin-3

Background
          Although MP20 is the second most highly expressed membrane protein in the lens its function remains an enigma. Putative functions for MP20 have recently been inferred from its assignment to the tetraspanin superfamily of integral membrane proteins. Members of this family have been shown to be involved in cellular proliferation, differentiation, migration, and adhesion. In this study, we show that MP20 associates with galectin-3, a known adhesion modulator.
        
        
          Results
          MP20 and galectin-3 co-localized in selected areas of the lens fiber cell plasma membrane. Individually, these proteins purified with apparent molecular masses of 60 kDa and 22 kDa, respectively. A 104 kDa complex was formed in vitro upon mixing the purified proteins. A 102 kDa complex of MP20 and galectin-3 could also be isolated from detergent-solubilized native fiber cell membranes. Binding between MP20 and galectin-3 was disrupted by lactose suggesting the lectin site was involved in the interaction.
        
        
          Conclusions
          MP20 adds to a growing list of ligands of galectin-3 and appears to be the first representative of the tetraspanin superfamily identified to possess this specificity.

Tags: galectin-3, lens-protein, membrane-protein, nih, protein-binding
Organization: U.S. Department of Health & Human Services