AndreaBozzo/ceres-open-data-index huggingface dataset:
Polytene chromosomes as indicators of phylogeny in several species groups of

Background
          Polytene chromosome banding patterns have long been used by Drosophila evolutionists to infer degree of relatedness among taxa. Recently, nucleotide sequences have preempted this traditional method. We place the classical Drosophila evolutionary biology tools of polytene chromosome inversion analysis in a phylogenetic context and assess their utility in comparison to nucleotide sequences.
        
        
          Results
          A simultaneous analysis framework was used to examine the congruence of the chromosomal inversion data with more recent DNA sequence data in four Drosophila species groups – the melanogaster, virilis, repleta, and picture wing. Inversions and nucleotides were highly congruent with one another based on incongruence length difference and partitioned Bremer support values. Inversion phylogenies were less resolved because of fewer numbers of characters. Partitioned Bremer supports, corrected for the number of characters in each matrix, were higher for inversion matrices.
        
        
          Conclusions
          Polytene chromosome data are highly congruent with DNA sequence data and, when placed in a simultaneous analysis framework, are shown to be more information rich than nucleotide data.

Tags: chromosomal-inversion, drosophila-species, nih, phylogenetic-analysis, polytene-chromosomes
Organization: U.S. Department of Health & Human Services
Table 22. 2011-2012 NSDUH Needing But Not Receiving Treatment for Alcohol Use in the Past Year, by Age Group and State

Table 22. Needing But Not Receiving Treatment for Alcohol Use in the Past Year, by Age Group and State: Percentages, Annual Averages Based on 2011 and 2012 NSDUHs. Results are provided by State and for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: alcohol-use-disorder, nsduh-data, samhsa, substance-use-treatment, unmet-treatment-need
Organization: U.S. Department of Health & Human Services
Twenty-four hour presence of physicians in the ICU

Intensive-care units (ICUs) must be utilised in the most efficient way. Greater input of intensivists leads to better outcomes and more efficient use of resources. 'Closed' ICUs operate as functional units with a competent on-site team and their own management under the supervision of a full-time intensivist directly responsible for the treatment. Twenty-four-hour coverage by on-site physicians is mandatory to maintain the service. At night, the on-site physicians need not necessarily be specialists as long as an experienced intensivist is on call. Because of the shortage of intensivists, such standards will be difficult to maintain everywhere, but they should, at least, be mandatory for larger hospitals serving as regional centres.

Tags: critical-care-outcomes, hospital-resource-management, icu-physician-staffing, intensivist-coverage, nih
Organization: U.S. Department of Health & Human Services
Analysis of a human brain transcriptome map

Background
          Genome wide transcriptome maps can provide tools to identify candidate genes that are over-expressed or silenced in certain disease tissue and increase our understanding of the structure and organization of the genome. Expressed Sequence Tags (ESTs) from the public dbEST and proprietary Incyte LifeSeq databases were used to derive a transcript map in conjunction with the working draft assembly of the human genome sequence.
        
        
          Results
          Examination of ESTs derived from brain tissues (excluding brain tumor tissues) suggests that these genes are distributed on chromosomes in a non-random fashion. Some regions on the genome are dense with brain-enriched genes while some regions lack brain-enriched genes, suggesting a significant correlation between distribution of genes along the chromosome and tissue type. ESTs from brain tumor tissues have also been mapped to the human genome working draft. We reveal that some regions enriched in brain genes show a significant decrease in gene expression in brain tumors, and, conversely that some regions lacking in brain genes show an increased level of gene expression in brain tumors.
        
        
          Conclusions
          This report demonstrates a novel approach for tissue specific transcriptome mapping using EST-based quantitative assessment.

Tags: brain-transcriptome, brain-tumor, expressed-sequence-tags, gene-expression, nih
Organization: U.S. Department of Health & Human Services
Bouveret's syndrome complicated by distal gallstone ileus after laser lithotropsy using Holmium: YAG laser

Background
          Bouveret's syndrome is an unusual presentation of duodenal obstruction caused by the passage of a large gallstone through a cholecystoduodenal fistula. Endoscopic therapy has been used as first-line treatment, especially in patients with high surgical risk.
        
        
          Case presentation
          We report a 67-year-old woman who underwent an endoscopic attempt to fragment and retrieve a duodenal stone using a Holmium: Yttrium-Aluminum-Garnet Laser (Ho:YAG) which resulted in small bowel obstruction. The patient successfully underwent enterolithotomy without cholecystectomy or closure of the fistula.
        
        
          Conclusion
          We conclude that, distal gallstone obstruction, due to migration of partially fragmented stones, can occur as a possible complication of laser lithotripsy treatment of Bouveret's syndrome and might require urgent enterolithotomy.

Tags: bouverets-syndrome, duodenal-obstruction, gallstone-ileus, laser-lithotripsy, nih
Organization: U.S. Department of Health & Human Services
2012 State Profile - Oklahoma

This is a National Survey of Substance Abuse Treatment Services (N-SSATS) annual report showing the state profile for Oklahoma in 2012. N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 States, the District of Columbia, and other U.S. jurisdictions.

Tags: n-ssats, oklahoma, samhsa, substance-abuse-treatment, survey
Organization: U.S. Department of Health & Human Services
Compliance characteristics of the Portex Soft Seal Cuff improves seal
		  against leakage of fluid in a pig trachea model

Background:
          The Portex Soft Seal high-volume, low-pressure cuffed tracheal
				tube was compared with the Mallinckrodt HiLo, Sheridan Preformed and Portex
				Profile tracheal tubes for leakage of dye placed in the subglottic space of a
				pig's trachea which was used in a benchtop mechanical ventilation model
				and in six isolated pig tracheas.
        
        
          Results:
          There was no leakage, either in the ventilation model or in the
				isolated tracheas in the Portex Soft Seal group. There was rapid leakage in the
				ventilation model and in all the isolated tracheas for the Mallinckrodt HiLo,
				and five out of six isolated tracheas for the Sheridan Preformed and the Portex
				Profile group.
        
        
          Conclusions:
          This benchtop study suggests that the improved compliance
				characteristics of the Portex Soft Seal cuff are beneficial in preventing
				leakage of fluid in these models.

Tags: cuff-leakage, nih, tracheal-intubation, tracheal-tubes, ventilator-associated-pneumonia
Organization: U.S. Department of Health & Human Services
Kansas (KS)

This report presents estimates for measures of substance use and mental health based on the combined 2010 and 2011 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for Kansas for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: ks-behavioral-health, mental-health, samhsa, substance-use, suicidal-ideation
Organization: U.S. Department of Health & Human Services
Child and Family Services Reviews Update: Volume 9, Issue 1, October 2016

This issue of Child and Family Services Reviews Update contains the following sections: Modifications to the Use of CFSR Statewide Data Indicators, Online Monitoring System: Modifications, Year 3 CFSR News: Six States Request Traditional Reviews, NEW on the CFSR Portal: Round 3 Local Site Coordinator Toolkit, and Overview of the CFSR Unit.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: assessment, child, policy, reporting, scope
Organization: U.S. Department of Health & Human Services
Compound 525334: 1-(6'-hydroxyhexyl)-3-methyl-7-propylxanthine, O-TFA

Chemical compound data from PubChem database. IUPAC Name: 6-(3-methyl-2,6-dioxo-7-propylpurin-1-yl)hexyl 2,2,2-trifluoroacetate. Molecular Formula: C17H23F3N4O4. Molecular Weight: 404.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2009 CMHS Uniform Reporting System Output Tables

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2009. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-program, evidence-based-practices, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Debate: Albumin administration should not be avoided

The recent Cochrane report on albumin administration is analysed and			 criticised on the grounds of clinical methodology, content and interpretation.			 Although it is naïve and illogical to treat hypoalbuminaemia with albumin			 infusions, a more balanced view on the use of albumin for resuscitation in			 acute hypovolaemia is necessary. Once the acute phase of critical illness is			 past, interstitial volume is often expanded causing oedema, with a low plasma			 volume. We argue for the use of salt-poor albumin solutions in this situation			 and conclude that, on current evidence, the assertion that albumin should be			 avoided in all situations is irrational and untenable.

Tags: albumin-administration, critical-illness, fluid-resuscitation, hypovolemia-resuscitation, nih
Organization: U.S. Department of Health & Human Services
Circulating cytotoxic CD8

Circulating CD8+ CD28- T cells were found to be expanded more in patients with ankylosing spondylitis than in an age-matched healthy population (41.2 ± 17.7% versus 18.6 ± 7.6%). The level of CD8+CD28- T cells was dependent on the disease status, but was independent of age. Most of the CD8+ CD28- T cells produced perforin after stimulation in vitro, in contrast to their CD8+CD28+ counterparts. From the clinical perspective, the percentage of the cytotoxic CD8+ CD28- T cells reflected a more severe course of disease, as it correlated with distinct movement restrictions, as well as the metrology score summarizing cervical rotation (in sitting position), chin-to-jugulum distance, thoracic Schober, chest expansion, and fingers-to-floor distance (P = 0.032).

Tags: ankylosing-spondylitis, cd8-t-cells, cytotoxic-t-cells, disease-severity, nih
Organization: U.S. Department of Health & Human Services
2011 CMHS Uniform Reporting System (URS) Output Tables for Wyoming

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2011. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, outcome-measures, samhsa, wyoming
Organization: U.S. Department of Health & Human Services
United States (US)

This report presents the United States\'s estimates for 25 measures of substance use and mental health based on the combined 2009 and 2010 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for the United States for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: drug-use, mental-health, national-survey, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Temperature measurement on neurological pulse generators during MR scans

According to manufacturers of both magnetic resonance imaging (MRI) machines, and implantable neurological pulse generators (IPGs), MRI is contraindicated for patients with IPGs. A major argument for this restriction is the risk to induce heat in the leads due to the electromagnetic field, which could be dangerous for the surrounding brain parenchyma. The temperature change on the surface of the case of an ITREL-III (Medtronic Inc., Minneapolis, MN) and the lead tip during MRI was determined. An anatomical realistic and a cubic phantom, filled with phantom material mimicking human tissue, and a typical lead configuration were used to imitate a patient who carries an IPG for deep brain stimulation. The measurements were performed in a 1.5 T and a 3.0 T MRI. 2.1°C temperature increases at the lead tip uncovered the lead tip as the most critical part concerning heating problems in IPGs. Temperature increases in other locations were low compared to the one at the lead tip. The measured temperature increase of 2.1°C can not be considered as harmful to the patient. Comparison with the results of other studies revealed the avoidance of loops as a practical method to reduce heating during MRI procedures.

Tags: deep-brain-stimulation, mri-safety, neurological-implants, nih, temperature-measurement
Organization: U.S. Department of Health & Human Services
Treatment Episode Data Set (TEDS): 2015, Discharges from Substance Use Treatment Services: Tables

These tables present national-level data from the Treatment Episode Data Set (TEDS) for treatment discharges in 2015. In particular, these tables summarize demographic information and substance use treatment characteristics—including gender, age at admission, race/ethnicity, number of prior treatment episodes, treatment referral source, and length of stay in treatment—among discharges aged 12 years and older in 2015 from facilities that report to state administrative data systems. The tables also examine the reason for discharge—for example, treatment completion or transfer to further treatment—and the type of treatment service provided. There were 1,549,628 records for discharges of clients in 2015 submitted by 47 states, the District of Columbia, and Puerto Rico. Oregon, South Carolina, and West Virginia had submitted no data or incomplete data for 2015 discharges as of March 16, 2018 [Table 1.1a].1 Of the 1,549,628 discharges reported, 92 percent (or 1,420,316 records) can be linked to TEDS admissions between 2000 and 2015

Tags: addiction-treatment, samhsa, substance-use-treatment, teds-discharges, treatment-episode-data
Organization: U.S. Department of Health & Human Services
A new direction in the pathogenesis of idiopathic pulmonary fibrosis?

A recent review article suggested that idiopathic pulmonary fibrosis (IPF) is a disease that is associated more with abnormal wound healing than with inflammation. Data derived from transgenic and gene transfer rodent models suggest that lung inflammation may be a necessary but insufficient component of IPF, and that at some point in the natural history of the disease IPF becomes no longer dependent on the inflammatory response for propagation. Altered microenvironment and involvement of epithelial cell/mesenchymal cell interaction are the most likely contributors to the pathogenesis of this chronic progressive disorder.

Tags: epithelial-mesenchymal-transition, idiopathic-pulmonary-fibrosis, lung-inflammation, nih, wound-healing
Organization: U.S. Department of Health & Human Services
Compound 525380: Hexadecyl heptafluorobutanoate

Chemical compound data from PubChem database. IUPAC Name: hexadecyl 2,2,3,3,4,4,4-heptafluorobutanoate. Molecular Formula: C20H33F7O2. Molecular Weight: 438.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
A protein folding potential that places the native states of a large number of proteins near a local minimum

Background
          We present a simple method to train a potential function for the protein folding problem which, even though trained using a small number of proteins, is able to place a significantly large number of native conformations near a local minimum. The training relies on generating decoys by energy minimization of the native conformations using the current potential and using a physically meaningful objective function (derivative of energy with respect to torsion angles at the native conformation) during the quadratic programming to place the native conformation near a local minimum.
        
        
          Results
          We also compare the performance of three different types of energy functions and find that while the pairwise energy function is trainable, a solvation energy function by itself is untrainable if decoys are generated by minimizing the current potential starting at the native conformation. The best results are obtained when a pairwise interaction energy function is used with solvation energy function.
        
        
          Conclusions
          We are able to train a potential function using six proteins which places a total of 42 native conformations within ~4 Å rmsd and 71 native conformations within ~6 Å rmsd of a local minimum out of a total of 91 proteins. Furthermore, the threading test using the same 91 proteins ranks 89 native conformations to be first and the other two as second.

Tags: energy-minimization, native-conformation, nih, potential-energy-function, protein-folding
Organization: U.S. Department of Health & Human Services
Molecular cloning and tissue distribution of mammalian L-threonine 3-dehydrogenases

Background
          In mammals, L-threonine is an indispensable amino acid. The conversion of L-threonine to glycine occurs through a two-step biochemical pathway involving the enzymes L-threonine 3-dehydrogenase and 2-amino-3-ketobutyrate coenzyme A ligase. The L-threonine 3-dehydrogenase enzyme has been purified and characterised, but the L-threonine 3-dehydrogenase gene has not previously been identified in mammals.
        
        
          Results
          Transcripts for L-threonine 3-dehydrogenase from both the mouse and pig are reported. The ORFs of both L-threonine dehydrogenase cDNAs encode proteins of 373 residues (41.5 kDa) and they share 80% identity. The mouse gene is located on chromosome 14, band C. The amino-terminal regions of these proteins have characteristics of a mitochondrial targeting sequence and are related to the UDP-galactose 4-epimerases, with both enzyme families having an amino-terminal NAD+ binding domain. That these cDNAs encode threonine dehydrogenases was shown, previously, by tiling 13 tryptic peptide sequences, obtained from purified L-threonine dehydrogenase isolated from porcine liver mitochondria, on to the pig ORF. These eukaryotic L-threonine dehydrogenases also have significant similarity with the prokaryote L-threonine dehydrogenase amino-terminus peptide sequence of the bacterium, Clostridium sticklandii. In murine tissues, the expression of both L-threonine dehydrogenase and 2-amino-3-ketobutyrate coenzyme A ligase mRNAs were highest in the liver and were also present in brain, heart, kidney, liver, lung, skeletal muscle, spleen and testis.
        
        
          Conclusions
          The first cloning of transcripts for L-threonine dehydrogenase from eukaryotic organisms are reported. However, they do not have any significant sequence homology to the well-characterised Escherichia coli L-threonine dehydrogenase.

Tags: amino-acid-metabolism, enzyme-characterization, l-threonine-3-dehydrogenase, mitochondrial-targeting, nih
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Vermont, 2015

This is a behavioral health report for the state of Vermont. The report utilizes data from the National Survey on Drug Use and Health (NSDUH), and the Uniform Reporting System. The topics addressed in the report include youth substance use, youth mental health and treatment, mental health and treatment, substance use and substance use treatment.

Tags: mental-health-treatment, samhsa, substance-use-treatment, vermont-behavioral-health, youth-substance-use
Organization: U.S. Department of Health & Human Services
Comparison of deferral rates using a computerized versus written blood donor questionnaire: a randomized, cross-over study [ISRCTN84429599]

Background
          Self-administered computer-assisted blood donor screening strategies may elicit more accurate responses and improve the screening process.
        
        
          Methods
          Randomized crossover trial comparing responses to questions on a computerized hand-held tool (HealthQuiz, or HQ), to responses on the standard written instrument (Donor Health Assessment Questionnaire, or DHAQ). Randomly selected donors at 133 blood donation clinics in the area of Hamilton, Canada participated from 1995 to 1996. Donors were randomized to complete either the HQ or the DHAQ first, followed by the other instrument. In addition to responses of 'yes' and 'no' on both questionnaires, the HQ provided a response option of 'not sure'. The primary outcome was the number of additional donors deferred by the HQ.
        
        
          Results
          A total of 1239 donors participated. Seventy-one potential donors were deferred as a result of responses to the questionnaires; 56.3% (40/71) were deferred by the DHAQ, and an additional 43.7% (31/71) were deferred due to risks identified by the HQ but not by the DHAQ. Fourteen donors self-deferred; 11 indicated on the HQ that they should not donate blood on that day but did not use the confidential self-exclusion option on the DHAQ, and three used the self-exclusion option on the DHAQ but did not indicate that they should not donate blood on the HQ. The HQ identified a blood contact or risk factor for HIV/AIDS or sexually transmitted infection that was not identified by the DHAQ in 0.1% to 2.7% of donors.
        
        
          Conclusion
          A self-administered computerized questionnaire may increase risk reporting by blood donors.

Tags: blood-donation, blood-donor-screening, computerized-questionnaire, donor-deferral-rates, nih
Organization: U.S. Department of Health & Human Services