AndreaBozzo/ceres-open-data-index huggingface dataset:
Compound 527335: 2-(2,5-Dimethylphenyl)adamantane

Chemical compound data from PubChem database. IUPAC Name: 2-(2,5-dimethylphenyl)adamantane. Molecular Formula: C18H24. Molecular Weight: 240.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2019 Uniform Reporting System (URS) Table for New Jersey

These are the 2019 Uniform Reporting System (URS) Output Tables for New Jersey. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-program, evidence-based-practices, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Compound 525408: 2-Methyl-3,7-dithiaoctane

Chemical compound data from PubChem database. IUPAC Name: 1-methylsulfanyl-3-propan-2-ylsulfanylpropane. Molecular Formula: C7H16S2. Molecular Weight: 164.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Genetic epidemiology: Systemic lupus erythematosus

Systemic lupus erythematosus is the prototype multisystem autoimmune disease. A strong genetic component of susceptibility to the disease is well established. Studies of murine models of systemic lupus erythematosus have shown complex genetic interactions that influence both susceptibility and phenotypic expression. These models strongly suggest that several defects in similar pathways, e.g. clearance of immune complexes and/or apoptotic cell debris, can all result in disease expression. Studies in humans have found linkage to several overlapping regions on chromosome 1q, although the precise susceptibility gene or genes in these regions have yet to be identified. Recent studies of candidate genes, including Fcγ receptors, IL-6, and tumour necrosis factor-α, suggest that in human disease, genetic factors do play a role in disease susceptibility and clinical phenotype. The precise gene or genes involved and the strength of their influence do, however, appear to differ considerably in different populations.

Tags: autoimmune-disease, genetic-epidemiology, nih, sle-genetics, systemic-lupus
Organization: U.S. Department of Health & Human Services
Glossary of DAWN Terms, 2011 Update

This glossary defines terms used in data collection activities, analyses, and publications associated with the emergency department (ED) component of the Drug Abuse Warning Network (DAWN). The glossary is updated to reflect terms and conventions applicable in the 2011 data collection year.

Tags: dawn-terminology, drug-abuse, emergency-department, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
Pennsylvania 2016 Potential Areas for Addressing Service Gaps for Opioid Treatment

The purpose of the medication-assisted treatment (MAT) facility maps is to identify areas on a state-by-state basis that may be potentially underserved by existing treatment facilities. The maps are created with a methodology that seeks to include the highest potential need areas from individual counties so that county-level stakeholders are also informed. The maps are meant to be used as a tool for policy makers to determine potentially underserved areas—not as a definitive representation of these areas.

Tags: mat-access, opioid-treatment, pennsylvania, samhsa, service-gap-analysis
Organization: U.S. Department of Health & Human Services
2018 Uniform Reporting System (URS) Table for New Jersey

This is the 2018 Uniform Reporting System (URS) Output Tables for New Jersey. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-data, evidence-based-practices, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Compound 525354: 2,2-Dimethyl-4,5-dithiahexane

Chemical compound data from PubChem database. IUPAC Name: 2,2-dimethyl-1-(methyldisulfanyl)propane. Molecular Formula: C6H14S2. Molecular Weight: 150.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Activation of macrophages by silicones: phenotype and production of oxidant metabolites

Background
          The effect of silicones on the immune function is not fully characterized. In clinical and experimental studies, immune alterations associated with silicone gel seem to be related to macrophage activation. In this work we examined in vivo, phenotypic and functional changes on peritoneal macrophages early (24 h or 48 h) and late (45 days) after the intraperitoneal (i.p.) injection of dimethylpolysiloxane (DMPS) (silicone). We studied the expression of adhesion and co-stimulatory molecules and both the spontaneous and the stimulated production of reactive oxygen intermediates and nitric oxide (NO).
        
        
          Results
          The results presented here demonstrate that the fluid compound DMPS induced a persistent cell recruitment at the site of the injection. Besides, cell activation was still evident 45 days after the silicone injection: activated macrophages exhibited an increased expression of adhesion (CD54 and CD44) and co-stimulatory molecules (CD86) and an enhanced production of oxidant metabolites and NO.
        
        
          Conclusions
          Silicones induced a persistent recruitment of leukocytes at the site of the injection and macrophage activation was still evident 45 days after the injection.

Tags: immune-response, macrophage-activation, nih, oxidant-metabolites, silicone-implants
Organization: U.S. Department of Health & Human Services
2016 NSDUH Data Collection Final Report

The report addresses the following topics relating to data collection for the 2016 NSDUH: Sampling and Counting and Listing Operations, Data Collection Staffing,Preparation of Survey Materials, Field Staff Training, Data Collection, Data Collection Results, and Quality Control.

Tags: data-collection-methods, nsduh-data, samhsa, sampling-methodology, survey
Organization: U.S. Department of Health & Human Services
Compound 525504: 6-Methyl-4,5-dithia-1-octene

Chemical compound data from PubChem database. IUPAC Name: 2-(prop-2-enyldisulfanyl)butane. Molecular Formula: C7H14S2. Molecular Weight: 162.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
High serum alkaline phosphatase levels, a study in 181 Thai adult hospitalized patients

Background
          Alkaline phosphatase (ALP) is an important enzyme mainly derived from the liver, bones and in lesser amounts from intestines, placenta, kidneys and leukocytes. An increase in ALP levels in the serum is frequently associated with a variety of diseases. This study was done in order to determine the diseases associated with a high ALP level among Thai adult hospitalized patients.
        
        
          Method
          A review was made of medical records of inpatients with high ALP level above 1000 IU/L in King Chulalongkorn Memorial Hospital, Thailand from January 1999 to December 1999. Excluded were cases of (a) patients who have bone involvements with malignancies, (b) pediatric patients younger than 15 years old and c) HIV-seropositive patients.
        
        
          Results
          A total of 181 hospitalized patients with eligible medical records were identified (96 males and 85 females, mean age 49.4 ± 16.1 years). Their ALP levels ranging from 1,001 to 3,067 IU/L, these patients were divided into four groups.
        
        
          Conclusion
          High serum ALP levels in hospitalized patients were commonly found in three major groups having obstructive biliary diseases, infiltrative liver disease and sepsis. The study results were in accordance with previous reports in developed countries. Nonetheless, cholangiocarcionoma and some tropical diseases unique to our setting were also detected in these cases. where there was a marked elevation of serum ALP.

Tags: alkaline-phosphatase, hospitalized-patients, liver-diseases, nih, thailand
Organization: U.S. Department of Health & Human Services
The NSDUH Report: Monthly Variation in Substance Use Initiation among Adolescents

This report uses 2002 to 2010 National Survey on Drug Use and Health (NSDUH) to assess the average number of adolescents aged 12 to 17 using substances for the first time per day for the year as a whole and for each month of the year. Substances examined include alcohol, cigarettes, cigars, marijuana, nonmedical use of prescription type drugs, inhalants, hallucinogens, and cocaine. Results are shown for each substance by month.

Tags: adolescent-substance-use, monthly-substance-use, nsduh-data, samhsa, substance-use-initiation
Organization: U.S. Department of Health & Human Services
Compound 525239: N''-(3-ethoxy-phenyl)-N,N,N',N'-tetramethyl-guanidine

Chemical compound data from PubChem database. IUPAC Name: 2-(3-ethoxyphenyl)-1,1,3,3-tetramethylguanidine. Molecular Formula: C13H21N3O. Molecular Weight: 235.33. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
New Jersey (NJ)

This report presents New Jersey\'s estimates for 25 measures of substance use and mental health based on the combined 2009 and 2010 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for New Jersey for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: major-depression, mental-health, national-survey, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
2022 National Directory of Drug and Alcohol Abuse Treatment Facilities

TheNational Directory of Drug and Alcohol Abuse Treatment Facilities - 2022is a listing of federal, state, and local government facilities and private facilities that provide substance abuse treatment services. It includes treatment facilities that (1) are licensed, certified, or otherwise approved for inclusion in the Directory by their State Substance Abuse Agencies, and (2) responded to the 2021 National Substance Use and Mental Health Services Survey (N-SUMHSS). The information about each facility that appears in this Directory was provided by that facility in response to the 2021 N-SUMHSS. The N-SUMHSS is conducted annually by the Substance Abuse and Mental Health Services Administration (SAMHSA).  The 2022 Directory is available in PDF and Excel formats.The Directory is ordered alphabetically by state, by city within each state, and by facility name within each city. Each facility listing includes codes that represent the services offered and other features of the facility, including codes that indicate services for hearing impaired and non-English-speaking clients. Codes are defined in a key shown on pages v-x of the PDF file and as a separate tab on the Excel version. Because the services offered by a particular facility may change over time, it is always a good idea to verify the information in this Directory when contacting a facility.

Tags: alcohol-abuse-treatment, mental-health-services, samhsa, substance-abuse-treatment, treatment-facility-directory
Organization: U.S. Department of Health & Human Services
Rhode Island: 2011-2012 NSDUH

This report presents Rhode Island\'s estimates for 25 measures of substance use and mental health based on the combined 2011 and 2012 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided by State and for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: mental-health, nsduh, rhode-island, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Table 25. Had Serious Thoughts of Suicide in the Past Year, by Age Group and State: Percentages, Annual Averages Based on 2010 and 2011 NSDUHs

This report presents State estimates for serious thoughts of suicide in the past year based on the combined 2010 and 2011 National Surveys on Drug Use and Health (NSDUHs). Resuts are provided by age group.

Tags: age-groups, mental-health, nsduh-survey, samhsa, suicidal-ideation
Organization: U.S. Department of Health & Human Services
Compound 528434: 5-Ethylhexadecane

Chemical compound data from PubChem database. IUPAC Name: 5-ethylhexadecane. Molecular Formula: C18H38. Molecular Weight: 254.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Optimizing antibiotic therapy in the intensive care unit setting

Antibiotics are one of the most common therapies administered in the intensive care unit setting. In addition to treating infections, antibiotic use contributes to the emergence of resistance among pathogenic microorganisms. Therefore, avoiding unnecessary antibiotic use and optimizing the administration of antimicrobial agents will help to improve patient outcomes while minimizing further pressures for resistance. This review will present several strategies aimed at achieving optimal use of antimicrobial agents. It is important to note that each intensive care unit should have a program in place which monitors antibiotic utilization and its effectiveness. Only in this way can the impact of interventions aimed at improving antibiotic use (e.g. antibiotic rotation, de-escalation therapy) be evaluated at the local level.

Tags: antibiotic-stewardship, antibiotic-therapy, antimicrobial-resistance, icu-infections, nih
Organization: U.S. Department of Health & Human Services
2014 CMHS Uniform Reporting System (URS) Table for Minnesota

2014 Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for Minnesota. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, minnesota-mental-health, outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Dependence, Abuse, and Treatment Tables (Prevalence Estimates) - 5.1 to 5.56

These detailed tables present totals and prevalence estimates of substance dependence/abuse and treatment need/receipt from the 2010 National Survey on Drug Use and Health (NSDUH). Substances examined include illicit drugs, marijuana, cocaine, heroin, hallucinogens, inhalants, and the nonmedical use of prescription-type pain relievers, tranquilizers, stimulants, and sedatives, and alcohol. Results are provided by age group, gender, race/ethnicity, education level, employment status, and geographic area. Comparisons are made between 2010 and 2009.

Tags: drug-dependence, nsduh-data, samhsa, substance-abuse, treatment-prevalence
Organization: U.S. Department of Health & Human Services
Drug Abuse Warning Network Methodology Report, 2011 Update

This publication describes the methodologies used by the Drug Abuse Warning Network (DAWN), to collect, prepare, and analyze information on drug-related emergency department (ED) visits in the United States. The methods described here were initiated in 2004 and are current as of 2011.

Tags: data-collection-methods, dawn-network, drug-abuse, emergency-department, samhsa
Organization: U.S. Department of Health & Human Services
The diversity of microorganisms associated with

Background
          Molecular biological techniques are dramatically changing our view of microbial diversity in almost any environment that has so far been investigated. This study presents a systematic survey of the microbial diversity associated with a population of Acromyrmex leafcutter ants. In contrast to previous studies on social insects, which targeted specific groups of symbionts occurring in the gut (termites, Tetraponera ants) or in specialised cells (Camponotus ants) the objective of our present study was to do a total screening of all possible micro-organisms that can be found inside the bodies of these leafcutter ants.
        
        
          Results
          We amplified, cloned and sequenced SSU rRNA encoding gene fragments from 9 microbial groups known to have insect-associated representatives, and show that: (1) representatives of 5 out of 9 tested groups are present, (2) mostly several strains per group are present, adding up to a total of 33 different taxa. We present the microbial taxa associated with Acromymex ants in a phylogenetic context (using sequences from GenBank) to assess and illustrate to which known microorganisms they are closely related. The observed microbial diversity is discussed in the light of present knowledge on the evolutionary history of Acromyrmex leafcutter ants and their known mutualistic and parasitic symbionts.
        
        
          Conclusions
          The major merits of the screening approach documented here is its high sensitivity and specificity, which allowed us to identify several microorganisms that are promising candidates for further study of their interactions with Acromyrmex leafcutter ants or their gardens.

Tags: insect-microbiota, leafcutter-ants, microbial-diversity, nih, ssu-rrna
Organization: U.S. Department of Health & Human Services
National Survey of Substance Abuse Treatment Services: State Profiles 2010

The 2010 National Survey of Substance Abuse Treatment Services (N-SSATS) is an annual survey of facilities providing substance abuse treatment. The N-SSATS, conducted by the Substance Abuse and Mental Health Services Administration (SAMHSA), is designed to collect data on the location, characteristics, services offered, and number of clients in treatment at alcohol and drug abuse facilities (both public and private) throughout the 50 states, the District of Columbia, and other U.S. jurisdictions.

Tags: alcohol-drug-abuse, n-ssats, samhsa, substance-abuse-treatment, treatment-facilities
Organization: U.S. Department of Health & Human Services
Therapeutic utility of aspirin in the

Background
          In recent years it has become evident that nonsteroidal anti-inflammatory drugs, in particular aspirin represent a potential class of cancer chemotherapeutic agents. Despite the wealth of knowledge gained from epidemiological, clinical and animal studies, the effectiveness of aspirin to treat established gastrointestinal cancer has not been determined. The present study examines the ability of aspirin to treat established polyposis in Min/+ mice.
        
        
          Methods
          Min/+ mice with established polyposis were treated orally once daily from 12–16 weeks of age with either drug vehicle or aspirin (25 mg/kg). Upon completion of treatment, the number, location and size of intestinal tumours was determined. Additional variables examined were the number of apoptotic cells within tumours and COX activity.
        
        
          Results
          Administration of aspirin for 4 weeks to Min/+ mice produce no effect on tumour number compared to vehicle-treated Min/+ mice (65 ± 8 vs. 63 ± 9, respectively). In addition, aspirin had no effect on tumour size or location. However, aspirin treatment produced a greater than 2-fold (p < 0.05) increase in the number of apoptotic positive cells within tumours and significantly decreased hepatic PGE2 content.
        
        
          Conclusions
          Aspirin was found to have no effect on tumour number and size when administered to Min/+ mice with established polyposis. The findings in the present study call in to question the utility of aspirin as a stand-alone treatment for established GI cancer. However, aspirin's ability to significantly promote apoptosis may render it suitable for use in combinatorial chemotherapy.

Tags: aspirin-treatment, cancer-chemoprevention, intestinal-polyposis, min-mice, nih
Organization: U.S. Department of Health & Human Services
Illicit Drug Use Tables  (Prevalence Estimates) - 1.1 to 1.92

These detailed tables are population illicit drug use totals and prevalence estimates from the 2011 National Survey on Drug Use and Health (NSDUH). Illicit drugs include marijuana, cocaine, crack, heroin, hallucinogens, inhalants, and the nonmedical use of prescription-type psychotherapeutics, including pain relievers, tranquilizers, stimulants, and sedatives. Results are provided for lifetime, past year, and past month use by age group, gender, race/ethnicity, education level, employment status, and geographic area. Comparisons are made between 2011 and 2010.

Tags: drug-prevalence, illicit-drug-use, nsduh-data, samhsa, substance-use-survey
Organization: U.S. Department of Health & Human Services
National Estimates of Drug-Related Emergency Department Visits, 2004-2011 - Accidental Ingestions

Excel file with national estimates, rates, relative standard errors, trends and confidence intervals, covering 2004-2011 for emergency department visits involving accidental ingestions. This analytic category includes ED visits in which an individual accidentally or unknowingly used or was administered a prescription drug, over-the-counter medication, or dietary supplement. Drug-related accidental ingestion typically involves patients aged 5 and under.  This analytic category does not include drug misuse or abuse.File includes data for over 500 drugs, including illicit drugs, prescription and over-the-counter medications, dietary supplements, inhalants and alcohol.  Includes total visits, gender, age group, race/ethnicity, outcome of visit, drug combinations, number of drugs involved in visit, drug frequency, and drugs confirmed by toxicology.Additional detail is provided for illicit drugs, psychotherapeutic drugs, central nervous system (CNS) drugs, respiratory drugs and cardiovascular drugs.

Tags: accidental-ingestion, drug-related-events, emergency-department-visits, pediatric-poisoning, samhsa
Organization: U.S. Department of Health & Human Services