AndreaBozzo/ceres-open-data-index huggingface dataset:
Compound 528197: Benzeneacetic acid, 2,3',4'-trihydroxy, bis-DTBS

Chemical compound data from PubChem database. IUPAC Name: 2,2-ditert-butyl-5-(2,2-ditert-butyl-1,3,2-benzodioxasilol-5-yl)-1,3,2-dioxasilolan-4-one. Molecular Formula: C24H40O5Si2. Molecular Weight: 464.7. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 529454: 2-(Diphenylphosphorothioyl)phenyl diphenylphosphinate

Chemical compound data from PubChem database. IUPAC Name: (1-methyl-7-prop-1-en-2-yl-1,2,3,5,6,7,8,8a-octahydroazulen-4-yl)methanol. Molecular Formula: C15H24O. Molecular Weight: 220.35. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Patent AT-E401587-T1: [Translated] EARTH ELECTRODE ASSEMBLY FOR AN UNDERWATER ELECTRICAL DEVICE

A cable system including an earthing electrode assembly for providing a submerged electrical apparatus with an earth path. The electrode assembly is provided with an earthing electrode and with attachment means so that the electrode assembly is capable of attachment to a cable. The electrode assembly is also provided with an insulated electrical connection for connecting the electrode to the submerged electrical apparatus.  The cable system is provided with a hydrogen barrier layer located between the earthing electrode and the center of the cable and extends a predetermined distance on either side of the position of the electrode.

Tags: chemistry, innovation, patent, pubchem, research
Organization: U.S. Department of Health & Human Services
Compound 528239: 2-Butylthiane

Chemical compound data from PubChem database. IUPAC Name: 2-butylthiane. Molecular Formula: C9H18S. Molecular Weight: 158.31. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 530503: 3-Cyclopentylpropionic acid, 1-adamantylmethyl ester

Chemical compound data from PubChem database. IUPAC Name: 1-adamantylmethyl 3-cyclopentylpropanoate. Molecular Formula: C19H30O2. Molecular Weight: 290.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 527345: 16,20,24,28-Tetramethyl-dotriacontyl cyanide

Chemical compound data from PubChem database. IUPAC Name: 17,21,25,29-tetramethyltetratriacontanenitrile. Molecular Formula: C38H75N. Molecular Weight: 546.0. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Patent AT-E40156-T1: [Translated] SELECTIVE PLATING.

A method of selective plating a component (1), which method comprises contacting upper and lower faces of the component (1) with upper and lower masks, respectively, so that the lower mask exposes a part of the component to be plated, positioning the component (1) over a plating tank and selective plating the component with a plating medium (18), the plating pressure and the hardness of the material comprising the upper mask (16) being such that the upper mask (16) is deformed during plating so as at least partially to mask the edge(s) of the said exposed part.

Tags: chemistry, innovation, patent, pubchem, research
Organization: U.S. Department of Health & Human Services
Compound 526803: 2-Hydroxy-nonadecanoic, methyl ester, 2-tBDMS ether

Chemical compound data from PubChem database. IUPAC Name: methyl 2-[tert-butyl(dimethyl)silyl]oxynonadecanoate. Molecular Formula: C26H54O3Si. Molecular Weight: 442.8. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Missouri (MO)

This report presents Missouri\'s estimates for 25 measures of substance use and mental health based on the combined 2009 and 2010 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for Missouri for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: mental-health, missouri, nsduh, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Compound 525766: Triethylpropoxysilane

Chemical compound data from PubChem database. IUPAC Name: triethyl(propoxy)silane. Molecular Formula: C9H22OSi. Molecular Weight: 174.36. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Patent AT-E401627-T1: [Translated] ELECTROMAGNETIC COUNTER WITH BUILT-IN LIGHTING ARRANGEMENT

An electromagnetic counter (A) includes a case (1), an electromagnet (2), an anchor (3) rotatable through magnetization and demagnetization of the electromagnet, and number wheels (4, 5) rotated by a predetermined angle according to the rotation of the anchor. A flexible board (15) with a light emitting diode (16) is disposed in a confined space in the case for illuminating the number wheels.

Tags: chemistry, innovation, patent, pubchem, research
Organization: U.S. Department of Health & Human Services
Genotyping in the MHC locus: potential for defining predictive markers in sarcoidosis

In sarcoidosis, host genetic factors are discussed as contributing to disease susceptibility and course. Since tumor necrosis factor (TNF)-α is a central mediator of granuloma formation and since elevated TNF-α levels are found during active phases of sarcoidosis, genetic polymorphisms correlating with influences on TNF-α levels are of special interest. The complete sequencing of the MHC region and the increase in the number of identified gene polymorphisms in this locus associated with TNF-α production offer the opportunity of detecting new genes associated with sarcoidosis and perhaps of defining disease-associated haplotypes that bear the potential of serving as predictive markers for this disease.

Tags: genetic-markers, mhc-locus, nih, sarcoidosis-genetics, tnf-alpha
Organization: U.S. Department of Health & Human Services
Compound 527577: Cyclohexene, 6-iodo-1-methyl

Chemical compound data from PubChem database. IUPAC Name: 6-iodo-1-methylcyclohexene. Molecular Formula: C7H11I. Molecular Weight: 222.07. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 527997: Propyl 2,2-dichloropropanoate

Chemical compound data from PubChem database. IUPAC Name: propyl 2,2-dichloropropanoate. Molecular Formula: C6H10Cl2O2. Molecular Weight: 185.05. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
National Survey of Substance Abuse Treatment Services: State Profiles 2013

The 2013 National Survey of Substance Abuse Treatment Services (N-SSATS) is an annual survey of facilities providing substance abuse treatment. The N-SSATS, conducted by the Substance Abuse and Mental Health Services Administration (SAMHSA), is designed to collect data on the location, characteristics, services offered, and number of clients in treatment at alcohol and drug abuse facilities (both public and private) throughout the 50 states, the District of Columbia, and other U.S. jurisdictions.

Tags: alcohol-drug-abuse, n-ssats, samhsa, substance-abuse-treatment, treatment-facilities
Organization: U.S. Department of Health & Human Services
2017 Uniform Reporting System (URS) Table for Federated States of Micronesia

This is the 2017 Uniform Reporting System (URS) Output Tables for Federated States of Micronesia. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, micronesia, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Compound 529363: His, N-isoBOC TBDMS

Chemical compound data from PubChem database. IUPAC Name: 2-methylpropyl 4-[3-[tert-butyl(dimethyl)silyl]oxy-2-(2-methylpropoxycarbonylamino)-3-oxopropyl]imidazole-1-carboxylate. Molecular Formula: C22H39N3O6Si. Molecular Weight: 469.6. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Patent AT-E400581-T1: [Translated] PEPTIDE ANTIOXIDANTS FROM SOY PROTEINS

The present invention is directed to antixoidant peptides produced by the proteolytic digestion of soy protein isolate. These peptides may be purified and used in either pharmaceutical or dietary compositions. <IMAGE>

Tags: chemistry, innovation, patent, pubchem, research
Organization: U.S. Department of Health & Human Services
Patent AT-E400993-T1: [Translated] MODULAR GREENING DEVICE FOR FACADES, WALLS, ETC.

The device has a carrying structure (19) with two spaced vertical rails (7) on which parallelepiped modules (4), mounted in vertical rows, are located at a distance from a facade or wall and dismounted individually. Each module with thickness lower than lateral dimensions has a base wall and solid lateral opposed walls. The lateral walls have fixing units (13) to cooperate with receiving sites (14) present on the rails.

Tags: chemistry, innovation, patent, pubchem, research
Organization: U.S. Department of Health & Human Services
Real-time RT-PCR analysis of mRNA decay: half-life of Beta-actin mRNA in human leukemia CCRF-CEM and Nalm-6 cell lines

Background
          We describe an alternative method to determine mRNA half-life (t1/2) based on the Real-Time RT-PCR procedure. This approach was evaluated by using the β-actin gene as a reference molecule for measuring of mRNA stability.
        
        
          Results
          Human leukemia Nalm-6 and CCRF-CEM cells were treated with various concentrations of Actinomycin D to block transcription and aliquots were removed periodically. Total RNA was isolated and quantified using the RiboGreen® fluorescent dye with the VersaFluor Fluorometer System. One μg of total RNA was reverse transcribed and used as template for the amplification of a region of the β-actin gene (231 bp). To generate the standard curve, serial ten-fold dilutions of the pBactin-231 vector containing the cDNA amplified fragment were employed, β-actin mRNAs were quantified by Real-Time RT-PCR using the SYBR® Green I fluorogenic dye and data analyzed using the iCycle iQ system software. Using this method, the β-actin mRNA exhibited a half-life of 6.6 h and 13.5 h in Nalm-6 and CCRF-CEM cells, respectively. The t1/2 value obtained for Nalm-6 is comparable to those estimated from Northern blot studies, using normal human leukocytes (5.5 h).
        
        
          Conclusions
          We have developed a rapid, sensitive, and reliable method based on Real-Time RT-PCR for measuring mRNA half-life. Our results confirm that β-actin mRNA half-life can be affected by the cellular growth rate.

Tags: beta-actin, leukemia-cell-lines, mrna-decay, nih, rt-pcr
Organization: U.S. Department of Health & Human Services
Compound 525654: p-Bromobenzylidene-(3-chlorophenyl)-amine

Chemical compound data from PubChem database. IUPAC Name: 1-(4-bromophenyl)-N-(3-chlorophenyl)methanimine. Molecular Formula: C13H9BrClN. Molecular Weight: 294.57. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 530420: Kauren-19-ol

Chemical compound data from PubChem database. IUPAC Name: (5,9,14-trimethyl-5-tetracyclo[11.2.1.01,10.04,9]hexadecanyl)methanol. Molecular Formula: C20H34O. Molecular Weight: 290.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 525645: N,N-Dimethyl-N'-pentyl-p-methylbenzamidine

Chemical compound data from PubChem database. IUPAC Name: N,N,4-trimethyl-N'-pentylbenzenecarboximidamide. Molecular Formula: C15H24N2. Molecular Weight: 232.36. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Patent AT-E400005-T1: [Translated] CLOCK WITH A ROTATING PART

The watch has a slit ring mounted to be locked axially and radially on a set of pinion/stem elements, and an axial locking unit for axially locking another set of the pinion/stem elements secured to the slit ring. The slit ring is mounted in a circular groove made in the former set of the pinion/stem elements. The axial locking unit is formed of an L-shaped arm which is engaged in a hollow e.g. circular groove, made in the latter set of the pinion/stem elements. The locking unit is formed of another slit ring connected to the former slit ring by a rigid arm.

Tags: chemistry, innovation, patent, pubchem, research
Organization: U.S. Department of Health & Human Services
Patent AT-E400354-T1: [Translated] MICROPOROUS MEMBRANE SUBSTRATE WITH BASE-STABLE, LOW PROTEIN-BINDING SURFACE

The present invention provides porous media or membranes having a surface coating that includes a first coating of a cross-linked terpolymer and a second coating comprising a copolymer or a terpolymer modified with a hydrophilic or hydrophobic functional group which has a superior combination of properties, including heat stable biomolecule resistant adsorptive properties, resistance to strong alkaline solutions, and low levels of extractable matter.

Tags: chemistry, innovation, patent, pubchem, research
Organization: U.S. Department of Health & Human Services
Compound 528984: 1,2-Pentacosanediol, di-TMS

Chemical compound data from PubChem database. IUPAC Name: trimethyl(1-trimethylsilyloxypentacosan-2-yloxy)silane. Molecular Formula: C31H68O2Si2. Molecular Weight: 529.0. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Interaction of the

Background
          Secretion of anti-host proteins by Yersinia pestis via a type III mechanism is not constitutive. The process is tightly regulated and secretion occurs only after an appropriate signal is received. The interaction of LcrG and LcrV has been demonstrated to play a pivotal role in secretion control. Previous work has shown that when LcrG is incapable of interacting with LcrV, secretion of anti-host proteins is prevented. Therefore, an understanding of how LcrG interacts with LcrV is required to evaluate how this interaction regulates the type III secretion system of Y. pestis. Additionally, information about structure-function relationships within LcrG is necessary to fully understand the role of this key regulatory protein.
        
        
          Results
          In this study we demonstrate that the N-terminus of LcrG is required for interaction with LcrV. The interaction likely occurs within a predicted amphipathic coiled-coil domain within LcrG. Our results demonstrate that the hydrophobic face of the putative helix is required for LcrV interaction. Additionally, we demonstrate that the LcrG homolog, PcrG, is incapable of blocking type III secretion in Y. pestis. A genetic selection was utilized to obtain a PcrG variant capable of blocking secretion. This PcrG variant allowed us to locate a region of LcrG involved in secretion blocking.
        
        
          Conclusion
          Our results demonstrate that LcrG interacts with LcrV via hydrophobic interactions located in the N-terminus of LcrG within a predicted coiled-coil motif. We also obtained preliminary evidence that the secretion blocking activity of LcrG is located between amino acids 39 and 53.

Tags: lcrg-lcrv-interaction, nih, type-iii-secretion, yersinia-pestis
Organization: U.S. Department of Health & Human Services
2017 Uniform Reporting System (URS) Table for Missouri

This is the 2017 Uniform Reporting System (URS) Output Tables for Missouri. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: mental-health-services, missouri-health, national-outcome-measures, samhsa, substance-abuse-treatment
Organization: U.S. Department of Health & Human Services
Compound 528123: 2-Ethylthio-5-isopropyl-3-methylpyrazine

Chemical compound data from PubChem database. IUPAC Name: 2-ethylsulfanyl-3-methyl-5-propan-2-ylpyrazine. Molecular Formula: C10H16N2S. Molecular Weight: 196.31. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 526844: 10-Hydroxy-stearic acid, methyl ester, tBDMS ether

Chemical compound data from PubChem database. IUPAC Name: methyl 10-[tert-butyl(dimethyl)silyl]oxyoctadecanoate. Molecular Formula: C25H52O3Si. Molecular Weight: 428.8. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 530678: Phenylacetic acid, tridec-2-ynyl ester

Chemical compound data from PubChem database. IUPAC Name: tridec-2-ynyl 2-phenylacetate. Molecular Formula: C21H30O2. Molecular Weight: 314.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Suicidal Thoughts and Behavior among Adults: Results from the 2015 National Survey on Drug Use and Health

This report presents estimates for suicidal thoughts, plans, and non-fatal attempts from the 2015 National Survey on Drug Use and Health (NSDUH) for adults aged 18 or older. Estimates are also included of those that had suicidal thoughts, their percentage of illicit drug use, substance use disorders, and major depressive episode.  Comparisons are made by sex and by age group.  Trends are examined between 2014 and 2014 and in some cases, 2008 and 2015.

Tags: adult-mental-health, major-depressive-episode, samhsa, substance-use-disorder, suicidal-ideation
Organization: U.S. Department of Health & Human Services
New Mexico (NM)

This report uses 2008 to 2010 National Survey on Drug Use and Health (NSDUH) to assess past year alcohol use disorder and illicit drug use disorder among persons aged 12 or older for New Mexico overall and for substate regions within New Mexico. Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE).

Tags: mental-health-indicators, new-mexico, nsduh-data, samhsa, substance-use-disorder
Organization: U.S. Department of Health & Human Services
Retroviral vectors for establishing tetracycline-regulated gene expression in an otherwise recalcitrant cell line

Background
          Tetracycline-regulated systems have been used to control the expression of heterologous genes in such diverse organisms as yeast, plants, flies and mice. Adaptation of this prokaryotic regulatory system avoids many of the problems inherent in other inducible systems. There have, however, been many reports of difficulties in establishing functioning stable cell lines due to the cytotoxic effects of expressing high levels of the tetracycline transactivator, tTA, from a strong viral promoter.
        
        
          Results
          Here we report the successful incorporation of tetracycline-mediated gene expression in a mouse mammary epithelial cell line, HC11, in which conventional approaches failed. We generated retroviruses in which tTA expression was controlled by one of three promoters: a synthetic tetracycline responsive promoter (TRE), the elongation factor 1-alpha promoter (EF1α) or the phosphoglycerate kinase-1 promoter (PGK), and compared the resulting cell lines to one generated using a cytomegalovirus immediate early gene promoter (CMV). In contrast to cells produced using the CMV and PGK promoters, those produced using the EF1α and TRE promoters expressed high levels of β-galactosidase in a tetracycline-dependent manner.
        
        
          Conclusions
          These novel retroviral vectors performed better than the commercially available system and may have a more general utility in similarly recalcitrant cell lines.

Tags: gene-expression, mammary-epithelial-cells, nih, retroviral-vectors, tetracycline-regulation
Organization: U.S. Department of Health & Human Services