AndreaBozzo/ceres-open-data-index huggingface dataset:
High frequency oscillatory ventilation attenuates the activation of alveolar macrophages and neutrophils in lung injury

Background:
          Recent investigations have shown that leukocyte activation is involved in the pathogenesis of ventilator-associated lung injury. This study was designed to investigate whether the inflammatory responses and deterioration of oxygenation in ventilator-associated lung injury are attenuated by high-frequency oscillatory ventilation (HFO). We analyzed the effects of HFO compared with conventional mechanical ventilation (CMV) on the activation of pulmonary macrophages and neutrophils in 10 female rabbits.
        
        
          Results:
          After surfactant depletion, the rabbits were ventilated by CMV or HFO at the same mean airway pressure. Surfactant-depletion followed by 4 h mechanical ventilation hindered pulmonary oxygenation in both groups. Impairment of oxygenation was less severe in the HFO group than in the CMV group. In the HFO group the infiltration of granulocytes into alveolar spaces occurred more readily than in the CMV group. Compared with CMV, HFO resulted in greater attenuation of β2-integrin expression, not only on granulocytes, but also on macrophages.
        
        
          Conclusions:
          In the surfactant-depleted lung, the activation of leukocytes was attenuated by HFO. Reduced inflammatory response correlated with decreased impairment of oxygenation. HFO may reduce lung injury via the attenuation of pulmonary inflammation.

Tags: lung-injury, macrophage-activation, neutrophil-activation, nih, oscillatory-ventilation
Organization: U.S. Department of Health & Human Services
Compound 527352: 16,20,24-Trimethyl-tritriacontyl cyanide

Chemical compound data from PubChem database. IUPAC Name: 17,21,25-trimethylpentatriacontanenitrile. Molecular Formula: C38H75N. Molecular Weight: 546.0. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 527353: 16,20-Dimethyl-dotriacontyl cyanide

Chemical compound data from PubChem database. IUPAC Name: 17,21-dimethyltritriacontanenitrile. Molecular Formula: C35H69N. Molecular Weight: 503.9. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Michigan (MI)

This report presents Michigan\'s estimates for 25 measures of substance use and mental health based on the combined 2009 and 2010 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for Michigan for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: mental-health, michigan, nsduh, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Treatment Episode Data Set (TEDS): 1992-1996, National Admissions to Substance Abuse Treatment Services

This report presents data from the Treatment Episode Data Set (TEDS) for 1996, and trend data for 1992 to 1996. The report provides information on the demographic and substance abuse characteristics of people aged 12 and older admitted to treatment for abuse of alcohol and/or drugs in facilities that report to individual state administrative data systems.

Tags: alcohol-drug-abuse, samhsa, substance-abuse-treatment, teds-data, treatment-admissions
Organization: U.S. Department of Health & Human Services
Reporting of measures of accuracy in systematic reviews of diagnostic literature

Background
          There are a variety of ways in which accuracy of clinical tests can be summarised in systematic reviews. Variation in reporting of summary measures has only been assessed in a small survey restricted to meta-analyses of screening studies found in a single database. Therefore, we performed this study to assess the measures of accuracy used for reporting results of primary studies as well as their meta-analysis in systematic reviews of test accuracy studies.
        
        
          Methods
          Relevant reviews on test accuracy were selected from the Database of Abstracts of Reviews of Effectiveness (1994–2000), which electronically searches seven bibliographic databases and manually searches key resources. The structured abstracts of these reviews were screened and information on accuracy measures was extracted from the full texts of 90 relevant reviews, 60 of which used meta-analysis.
        
        
          Results
          Sensitivity or specificity was used for reporting the results of primary studies in 65/90 (72%) reviews, predictive values in 26/90 (28%), and likelihood ratios in 20/90 (22%). For meta-analysis, pooled sensitivity or specificity was used in 35/60 (58%) reviews, pooled predictive values in 11/60 (18%), pooled likelihood ratios in 13/60 (22%), and pooled diagnostic odds ratio in 5/60 (8%). Summary ROC was used in 44/60 (73%) of the meta-analyses. There were no significant differences in measures of test accuracy among reviews published earlier (1994–97) and those published later (1998–2000).
        
        
          Conclusions
          There is considerable variation in ways of reporting and summarising results of test accuracy studies in systematic reviews. There is a need for consensus about the best ways of reporting results of test accuracy studies in reviews.

Tags: diagnostic-accuracy, meta-analysis, nih, sensitivity-specificity, systematic-review
Organization: U.S. Department of Health & Human Services
List of AFCARS Out-of-Home Care and Adoption and Guardianship Assistance Elements with response options

This is a list of the Out-of-Home Care and Adoption and Guardianship Assistance data elements with response options and regulatory citations as published in the AFCARS final rule issued on December 14, 2016 (81 FR 90524
  
  

)

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: adoption, data, policy, regulation, reporting
Organization: U.S. Department of Health & Human Services
CTLA4 gene polymorphisms are associated with, and linked to, insulin-dependent diabetes mellitus in a Russian population

Background
          The association between the human cytotoxic T lymphocyte-associated antigen-4 (CTLA4) gene and insulin-dependent diabetes mellitus (IDDM) is unclear in populations. We therefore investigated whether the gene conferred susceptibility to IDDM in a Russian population. We studied two polymorphic regions of the CTLA4 gene, the codon 17 dimorphism and the (AT)n microsatellite marker in the 3' untranslated region in 56 discordant sibling pairs and in 33 identical by descent (IBD) affected sibships.
        
        
          Results
          The Ala17 allele of the CTLA4 gene was preferentially transmitted from parents to diabetic offspring (p < 0.0001) as shown by the combined transmission/disequlibrium test (TDT) and sib TDT (S-TDT) analysis. A significant difference between diabetic and non-diabetic offspring was also observed for the transmission of alleles 17, 20, and 26 of the dinucleotide microsatellite. Allele 17 was transmitted significantly more frequently to affected offspring than to other children (p = 0.0112) whereas alleles 20 and 26 were transmitted preferentially to non-diabetic sibs (p = 0.045 and 0.00068 respectively). A nonrandom excess of the Ala17 CTLA4 molecular variant (maximum logarithm of odds score (MLS) of 3.26) and allele 17 of the dinucleotide marker (MLS = 3.14) was observed in IBD-affected sibling pairs.
        
        
          Conclusion
          The CTLA4 gene is strongly associated with, and linked to IDDM in a Russian population.

Tags: ctla4-gene, genetic-association-study, iddm, nih, russian-population
Organization: U.S. Department of Health & Human Services
2013 CMHS Uniform Reporting System (URS) Table for Vermont

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Tables for Vermont for 2013. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program.  State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, national-outcome-measures, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
Inter-rater agreement in the scoring of abstracts submitted to a primary care research conference

Background
          Checklists for peer review aim to guide referees when assessing the quality of papers, but little evidence exists on the extent to which referees agree when evaluating the same paper. The aim of this study was to investigate agreement on dimensions of a checklist between two referees when evaluating abstracts submitted for a primary care conference.
        
        
          Methods
          Anonymised abstracts were scored using a structured assessment comprising seven categories. Between one (poor) and four (excellent) marks were awarded for each category, giving a maximum possible score of 28 marks. Every abstract was assessed independently by two referees and agreement measured using intraclass correlation coefficients. Mean total scores of abstracts accepted and rejected for the meeting were compared using an unpaired t test.
        
        
          Results
          Of 52 abstracts, agreement between reviewers was greater for three components relating to study design (adjusted intraclass correlation coefficients 0.40 to 0.45) compared to four components relating to more subjective elements such as the importance of the study and likelihood of provoking discussion (0.01 to 0.25). Mean score for accepted abstracts was significantly greater than those that were rejected (17.4 versus 14.6, 95% CI for difference 1.3 to 4.1, p = 0.0003).
        
        
          Conclusions
          The findings suggest that inclusion of subjective components in a review checklist may result in greater disagreement between reviewers. However in terms of overall quality scores, abstracts accepted for the meeting were rated significantly higher than those that were rejected.

Tags: abstract-review, inter-rater-reliability, nih, peer-review-agreement, primary-care-research
Organization: U.S. Department of Health & Human Services
Table 3. Marijuana Use in the Past Month among Persons Aged 12 or Older, by State and Substate Regions: Percentages, Annual Averages Based on 2008, 2009, and 2010 NSDUHs

This table presents the 2008 to 2010 National Survey on Drug Use and Health (NSDUH) estimates of past month marijuana use by those aged 12 or older by State and substate regions.

Tags: adolescent-substance-use, marijuana-use, nsduh-data, samhsa, state-level-data
Organization: U.S. Department of Health & Human Services
2012 State Profile - Oregon

This is a National Survey of Substance Abuse Treatment Services (N-SSATS) annual report showing the state profile for Oregon in 2012. N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 States, the District of Columbia, and other U.S. jurisdictions.

Tags: alcohol-drug-services, oregon-state, samhsa, substance-abuse-treatment, treatment-facility-data
Organization: U.S. Department of Health & Human Services
Washington-Arlington-Alexandria, DC-VA-MD-WV

This report presents combined 2005 to 2010 National Survey on Drug Use and Health (NSDUH) results for those aged 12 or older in the Washington-Arlington-Alexandria, DC-VA-MD-WV metro area. The report includes estimates of substance use disorder, major depressive episode, illicit drug use, marijuana use, cigarette use, binge alcohol use, and the nonmedical use of prescription-type pain relievers. Results are provided for the Washington-Arlington-Alexandria metro area, the District of Columbia and the U.S. overall.

Tags: major-depression, metro-area-health, nsduh-data, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Exploring Case and Service Characteristics of Children in Long-Term Foster Care to Guide Organizational Decision Making for Implementing Practice and System Reforms

This presentation highlights three papers from the experiences of three Permanency Innovations Initiative (PII) grantees: Washoe County, Nevada, the California Partners for Permanency (CAPP) and the Kansas Intensive Permanency Project (KIPP). The presentation addresses the methods and analyses used to identify risk characteristics for long term foster care; the methods used to engage agency partners in their selection of strategies that will be tested; and to consider the benefits of university-agency partnerships for using implementation science to drive system and practice reforms.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: foster, grant, instruction, permanency, policy
Organization: U.S. Department of Health & Human Services
4.11b Facilities offering special programs or groups for specific client types, by facility operation and primary focus of facility: 2010. Percent

This is a National Survey of Substance Abuse Treatment Services (N-SSATS) data table showing facilities offering special programs or groups for specific client types, by facility operation and primary focus of facility in 2011. N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 States, the District of Columbia, and other U.S. jurisdictions.

Tags: client-populations, facility-characteristics, samhsa, special-programs, substance-abuse-treatment
Organization: U.S. Department of Health & Human Services
2018 Uniform Reporting System (URS) Table for North Carolina

This is the 2018 Uniform Reporting System (URS) Output Tables for North Carolina. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-data, mental-health-services, national-outcome-measures, north-carolina, samhsa
Organization: U.S. Department of Health & Human Services
2013 NSDUH Dependence, Abuse, and Treatment Tables  (Prevalence Estimates) - 5.1 to 5.56

These detailed tables present totals and prevalence estimates of substance dependence/abuse and treatment need/receipt from the 2013 National Survey on Drug Use and Health (NSDUH). Substances examined include illicit drugs, marijuana, cocaine, heroin, hallucinogens, inhalants, and the nonmedical use of prescription-type pain relievers, tranquilizers, stimulants, and sedatives, and alcohol. Results are provided by age group, gender, race/ethnicity, education level, employment status, and geographic area. Comparisons are made between 2013 and 2012.

Tags: drug-dependence, prevalence-estimates, samhsa, substance-abuse, treatment-need
Organization: U.S. Department of Health & Human Services
Compound 528379: 2,3,6-Trichloro-4-hydroxybenzaldehyde

Chemical compound data from PubChem database. IUPAC Name: 2,3,6-trichloro-4-hydroxybenzaldehyde. Molecular Formula: C7H3Cl3O2. Molecular Weight: 225.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Prevalence of attention deficit/hyperactivity disorder among adults in obesity treatment

Background
          Bariatric patients showing poor "focus" during treatment more often failed to lose weight or maintain reduced weight. Evaluation of these patients identified a number having attention deficit/hyperactivity disorder (ADHD), evidently a potent factor limiting successful weight control. After searches found no published reports describing comorbid ADHD and obesity, this report was conceived to begin exploring the prevalence and characteristics of these patients.
        
        
          Method
          Clinical records of 215 patients receiving obesity treatment during 2000 were reviewed. Data collected and analyzed included age, sex, beginning and ending body mass index (BMI), number of clinic visits, months of treatment, and diagnostic category (ADHD, some ADHD symptoms, non-ADHD). DSM-IV criteria were used, except age of onset was modified to <= 12 years.
        
        
          Results
          Whole sample ADHD prevalence was 27.4% (CI:21.1,32.9), but 42.6% (CI: 36.3% to 48.9%) for BMI >= 40. Mean weight loss among obese patients with ADHD (OB+ADHD) was 2.6 BMI (kg/m2) vs. 4.0 for non-ADHD (NAD) (p < 0.002). For BMI >= 40, OB+ADHD had BMI loss 2.9 vs. 7.0 (NAD) (p < 0.004). OB+ADHD had more clinic visits, with a trend  toward longer treatment duration.
        
        
          Conclusions
          ADHD was highly prevalent among obese patients and highest in those with extreme obesity. Comorbid obesity and ADHD symptoms rendered treatment less successful compared to NAD counterparts. Reasons for the comorbidity are unknown, but may involve brain dopamine or insulin receptor activity. If replicated in further studies, these findings have important implications for treatment of severe and extreme obesity.

Tags: adult-adhd, bmi-outcomes, comorbid-adhd-obesity, nih, obesity-treatment
Organization: U.S. Department of Health & Human Services
2020 Uniform Reporting System (URS) Table For New Jersey

This is the 2020 Uniform Reporting System (URS) Output Tables for New Jersey. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-program, evidence-based-practices, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Compound 527271: Lavandulyl isovalerate

Chemical compound data from PubChem database. IUPAC Name: (5-methyl-2-prop-1-en-2-ylhex-4-enyl) 3-methylbutanoate. Molecular Formula: C15H26O2. Molecular Weight: 238.37. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2015-2016 NSDUH State Estimates of Substance Use and Mental Disorders

State estimates for 15 measures of substance use and mental disorders based on the combined 2015 and 2016 National Surveys on Drug Use and Health (NSDUHs) are provided. The NSDUH is an annual survey of the civilian, noninstutionalized population of the United States aged 12 years or older. State and regional estimates are based on a small area estimation (SAE) methodology in which state-level NSDUH data are combined with county and census block group/tract-level data from the state.

Tags: mental-disorders, nsduh-survey, samhsa, state-estimates, substance-use
Organization: U.S. Department of Health & Human Services
Dynamic expression of a glutamate decarboxylase gene in multiple non-neural tissues during mouse development

Background
          Glutamate decarboxylase (GAD) is the biosynthetic enzyme for the neurotransmitter γ-aminobutyric acid (GABA). Mouse embryos lacking the 67-kDa isoform of GAD (encoded by the Gad1 gene) develop a complete cleft of the secondary palate. This phenotype suggests that this gene may be involved in the normal development of tissues outside of the CNS. Although Gad1 expression in adult non-CNS tissues has been noted previously, no systematic analysis of its embryonic expression outside of the nervous system has been performed. The objective of this study was to define additional structures outside of the central nervous system that express Gad1, indicating those structures that may require its function for normal development.
        
        
          Results
          Our analysis detected the localized expression of Gad1 transcripts in several developing tissues in the mouse embryo from E9.0-E14.5. Tissues expressing Gad1 included the tail bud mesenchyme, the pharyngeal pouches and arches, the ectodermal placodes of the developing vibrissae, and the apical ectodermal ridge (AER), mesenchyme and ectoderm of the limb buds.
        
        
          Conclusions
          Some of the sites of Gad1 expression are tissues that emit signals required for patterning and differentiation (AER, vibrissal placodes). Other sites correspond to proliferating stem cell populations that give rise to multiple differentiated tissues (tail bud mesenchyme, pharyngeal endoderm and mesenchyme). The dynamic expression of Gad1 in such tissues suggests a wider role for GABA signaling in development than was previously appreciated.

Tags: gaba-neurotransmitter, gad1-gene, mouse-embryo-development, nih, palate-cleft
Organization: U.S. Department of Health & Human Services
Compound 525564: N,N-Dimethyl-N'-(3-bromophenyl)-p-methylbenzamidine

Chemical compound data from PubChem database. IUPAC Name: N'-(3-bromophenyl)-N,N,4-trimethylbenzenecarboximidamide. Molecular Formula: C16H17BrN2. Molecular Weight: 317.22. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 528342: Benzoic acid, 3,6-dichloro-2-hydroxy, TMS

Chemical compound data from PubChem database. IUPAC Name: trimethylsilyl 3,6-dichloro-2-trimethylsilyloxybenzoate. Molecular Formula: C13H20Cl2O3Si2. Molecular Weight: 351.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Genetic stabilization by p53 involves growth regulatory and repair pathways

p53 performs a plethora of activities, which are directed towards
the maintenance of the genomic integrity and constitute its
universal role as a tumor suppressor. 1000 to 10000 latent p53
molecules are permanently available in order to monitor DNA
exchange processes in mitotically growing cells. After the
introduction of major DNA injuries the levels of
posttranslationally modified p53 proteins rise, which in turn
transcriptionally signal transient cell cycle arrest or apoptotic
cell death, depending on the extent of damage. Taken together,
p53 inhibits the manifestation of genomic instabilities at
different control levels both during naturally occurring metabolic
processes and in response to genotoxic treatments.

Tags: dna-repair, genomic-stability, nih, p53-protein, tumor-suppression
Organization: U.S. Department of Health & Human Services