AndreaBozzo/ceres-open-data-index huggingface dataset:
Compound 528332: Dehydronepetalactone

Chemical compound data from PubChem database. IUPAC Name: 4,7-dimethyl-6,7-dihydro-5H-cyclopenta[c]pyran-1-one. Molecular Formula: C10H12O2. Molecular Weight: 164.2. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
The CONSORT statement: revised recommendations for improving the quality of reports of parallel group randomized trials

To comprehend the results of a randomized controlled trial (RCT), readers must understand its design, conduct, analysis and interpretation. That goal can only be achieved through complete transparency from authors. Despite several decades of educational efforts, the reporting of RCTs needs improvement. Investigators and editors developed the original CONSORT (Consolidated Standards of Reporting Trials) statement to help authors improve reporting by using a checklist and flow diagram. The revised CONSORT statement presented in this paper incorporates new evidence and addresses some criticisms of the original statement.
        The checklist items pertain to the content of the Title, Abstract, Introduction, Methods, Results and Discussion. The revised checklist includes 22-items selected because empirical evidence indicates that not reporting the information is associated with biasedestimates of treatment effect or the information is essential to judge the reliability or relevance of the findings. We intended the flow diagram to depict the passage of participants through an RCT. The revised flow diagram depicts information from four stages of a trial (enrolment, intervention allocation, follow-up, and analysis). The diagram explicitly includes the number of participants, for each intervention group, included in the primary data analysis. Inclusion of these numbers allows the reader to judge whether the authors have performed an intention-to-treat analysis.
        In sum, the CONSORT statement is intended to improve the reporting of an RCT, enabling readers to understand a trial's conduct and to assess the validity of its results.

Tags: consort-statement, nih, randomized-controlled-trials, research-reporting-guidelines, trial-transparency
Organization: U.S. Department of Health & Human Services
2012 State Profile - Montana

This is a National Survey of Substance Abuse Treatment Services (N-SSATS) annual report showing the state profile for Montana in 2012. N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 States, the District of Columbia, and other U.S. jurisdictions.

Tags: montana-health, n-ssats, samhsa, substance-abuse-treatment, treatment-facility-data
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Virginia, 2013

This is a behavioral health report for the state of Virginia. It uses the  National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment Services (NSSATS) to address the topics of youth substance use , youth mental health and treatment, adult mental health and treatment, substance use, substance use treatment for the years 2008 to 2012.

Tags: adult-mental-health, samhsa, substance-abuse-treatment, virginia-behavioral-health, youth-substance-use
Organization: U.S. Department of Health & Human Services
Delaware 2016 Potential Areas for Addressing Service Gaps for Opioid Treatment

The purpose of the medication-assisted treatment (MAT) facility maps is to identify areas on a state-by-state basis that may be potentially underserved by existing treatment facilities. The maps are created with a methodology that seeks to include the highest potential need areas from individual counties so that county-level stakeholders are also informed. The maps are meant to be used as a tool for policy makers to determine potentially underserved areas—not as a definitive representation of these areas.

Tags: delaware, mat-access, opioid-treatment, samhsa, service-gap-analysis
Organization: U.S. Department of Health & Human Services
1.5 Million Young Adults Do Not Receive Needed Mental Health Services

This spotlight uses combined 2009 to 2013 National Survey on Drug Use and Health to assess  reasons for not receiving mental health services among young adults aged 18 to 25 who felt they needed mental health services in the past year.

Tags: mental-health-services, nsduh-data, samhsa, unmet-mental-health-needs, young-adult-mental-health
Organization: U.S. Department of Health & Human Services
Monoclonal antibodies against the iron regulated outer membrane Proteins of

Background
          Iron is an important nutrient required by all forms of life.In the case of human hosts,the free iron availability is 10-18M,which is far less than what is needed for the survival of the invading bacterial pathogen.To survive in such conditions, bacteria express new proteins in their outer membrane and also secrete iron chelators called siderophores.
        
        
          Results/ Discussion
          Acinetobacter baumannii ATCC 19606, a nosocomial pathogen which grows under iron restricted conditions, expresses four new outer membrane proteins,with molecular weight ranging from 77 kDa to 88 kDa, that are called Iron Regulated Outer Membrane Proteins (IROMPs). We studied the functional and immunological properties of IROMPs expressed by A.baumanii ATCC 19606.The bands corresponding to IROMPs were eluted from SDS-PAGE and were used to immunize BALB/c mice for the production of monoclonal antibodies. Hybridomas secreting specific antibodies against these IROMPs were selected after screening by ELISA and their reactivity was confirmed by Western Blot. The antibodies then generated belonged to IgM isotype and showed bactericidical and opsonising activities against A.baumanii in vitro.These antibodies also blocked siderophore mediated iron uptake via IROMPs in bacteria.
        
        
          Conclusion
          This proves that iron uptake via IROMPs,which is mediated through siderophores,may have an important role in the survival of A.baumanii inside the host,and helps establishing the infection.

Tags: acinetobacter-baumannii, iron-regulated-proteins, monoclonal-antibodies, nih, outer-membrane-proteins
Organization: U.S. Department of Health & Human Services
Conservation of long-range synteny and microsynteny between the genomes of two distantly related nematodes

To assess whether the pattern of high rates of genome rearrangement, with a bias towards within-chromosome events is true of nematodes in general, genome sequence was used to compare the model Caenorhabditis elegans and the filarial parasite Brugia malayi. It is suggested that intrachromosomal rearrangement is a major force driving chromosomal organization in nematodes.

Tags: brugia-malayi, caenorhabditis-elegans, genome-rearrangement, nematode-genomes, nih
Organization: U.S. Department of Health & Human Services
Lung surfactant in subacute pulmonary disease

Pulmonary surfactant is a surface active material composed of both lipids and proteins that is produced by alveolar type II pneumocytes. Abnormalities of surfactant in the immature lung or in the acutely inflamed mature lung are well described. However, in a variety of subacute diseases of the mature lung, abnormalities of lung surfactant may also be of importance. These diseases include chronic obstructive pulmonary disease, asthma, cystic fibrosis, interstitial lung disease, pneumonia, and alveolar proteinosis. Understanding of the mechanisms that disturb the lung surfactant system may lead to novel rational therapies for these diseases.

Tags: lung-function, lung-surfactant, nih, pulmonary-disease, respiratory-disease
Organization: U.S. Department of Health & Human Services
Compound 528481: Docosane, 4-ethyl

Chemical compound data from PubChem database. IUPAC Name: 4-ethyldocosane. Molecular Formula: C24H50. Molecular Weight: 338.7. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Quality Improvement Center for Adoption and Guardianship Support and Preservation (QIC-AG)

The Children’s Bureau, Administration for Children and Families, Department of Health and Human Service established the National Quality Improvement Center for Adoption and Guardianship Support and Preservation (QIC-AG). In October 2014, the QIC-AG was awarded to Spaulding for Children in partnership with The University of Texas at Austin, The University of Wisconsin at Milwaukee, and The University of North Carolina at Chapel Hill. The QIC-AG was designed to promote permanence, when reunification is no longer a goal, and improve adoption and guardianship preservation and support.

For five years, the QIC-AG team worked with eight sites across the nation, with the purpose to implement evidence-based interventions or develop and test promising practices which, if proven effective, could be replicated or adapted in other child welfare jurisdictions. However, for the NDACAN archive, data from only 6 of the sites are included. These sites are from the following jurisdictions: Catawba County (NC), Illinois, New Jersey, Tennessee, Vermont and Wisconsin.

The six sites included in the NDACAN dataset all served the following broad target population, defined by the funder as: “Children and youth and their adoptive or guardianship families who have already finalized the adoption or guardianship and for whom stabilization may be threatened will also be targeted for support and service interventions. The children and youth in this target group may have been adopted through the child welfare system or by private domestic or intercountry private agency involvement.”

The primary research question was: Do families with a finalized adoption or guardianship have increased post-permanency stability and improved well-being if they receive post permanency services and support compared with similar families who receive services as usual? The project’s short-term outcomes varied by site and included, for example, increased level of caregiver commitment; reduced levels of family stress; improved familial relationships; and reduced child behavioral issues. The project had three long-term outcomes: increased post-permanency stability, improved behavioral health for children, and improved child and family well-being.

Investigators: Nancy Rolock, PhD
Case Western Reserve University, Cleveland, OHRowena Fong, EdD
The University of Texas at Austin,  Austin, TX

Tags: abuse, care, ndacan, policy, reporting
Organization: U.S. Department of Health & Human Services
Compound 525360: 2,3,6,7-Tetramethyl-4,5-dithiaoctane

Chemical compound data from PubChem database. IUPAC Name: 2-methyl-3-(3-methylbutan-2-yldisulfanyl)butane. Molecular Formula: C10H22S2. Molecular Weight: 206.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 528532: Hexadecane, 6-pentyl

Chemical compound data from PubChem database. IUPAC Name: 6-pentylhexadecane. Molecular Formula: C21H44. Molecular Weight: 296.6. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Inhaled nitric oxide reverses cell-free hemoglobin-induced pulmonary hypertension and decreased lung compliance. Preliminary results

Background:
          In order to test the hypothesis that inhaled nitric oxide (NO) reverses the pulmonary hypertension induced by αα-diaspirin crosslinked hemoglobin (ααHb), were studied anesthetized pigs that were administered with a total dose of 200 mg/kg of 10% ααHb. Inhaled NO (5 ppm) was administered for 10 min, and then discontinued for 10 min. This cycle was then repeated with 10 ppm inhaled NO.
        
        
          Results:
          ααHb caused pulmonary arterial pressure (PAP) to increase from 27 ± 1.7 to 40 ± 3.0 mmHg (P<0.05) and dynamic lung compliance to decrease from 29± 1.5 to 23± 1.6 ml/cmH2O (P < 0.05). After both doses of inhaled NO, but particularly 10 ppm, PAP was reduced (P < 0.05) and lung compliance increased (P < 0.05) from the ααHb levels. When inhaled NO was discontinued PAP again increased and lung compliance decreased to levels significantly different from baseline (P < 0.05).
        
        
          Conclusion:
          We conclude that cell-free hemoglobin-induced pulmonary hypertension and decreased lung compliance can be selectively counteracted by inhaled NO.

Tags: cell-free-hemoglobin, inhaled-nitric-oxide, lung-compliance, nih, pulmonary-hypertension
Organization: U.S. Department of Health & Human Services
2016 Uniform Reporting System (URS) Table for Guam

This is the 2016 Uniform Reporting System (URS) Output Tables for Guam. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, guam-mental-health, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
2016 Uniform Reporting System (URS) Table for Tennessee

This is the 2016 Uniform Reporting System (URS) Output Tables for Tennessee. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, evidence-based-practices, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
4.13 Facilities detoxifying clients, by substance, facility operation, and primary focus of facility: 2011. Number and percent

This is a National Survey of Substance Abuse Treatment Services (N-SSATS) data table showing facilities detoxifying clients, by substance, facility operation, and primary focus of facility in 2011. N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 States, the District of Columbia, and other U.S. jurisdictions.

Tags: detoxification-services, facility-characteristics, n-ssats, samhsa, substance-abuse-treatment
Organization: U.S. Department of Health & Human Services
Discontinuous and non-discontinuous subgenomic RNA transcription in a nidovirus

Arteri-, corona-, toro- and roniviruses are evolutionarily related positive-strand RNA viruses, united in the order Nidovirales. The best studied nidoviruses, the corona- and arteriviruses, employ a unique transcription mechanism, which involves discontinuous RNA synthesis, a process resembling similarity-assisted copy-choice RNA recombination. During infection, multiple subgenomic (sg) mRNAs are transcribed from a mirror set of sg negative-strand RNA templates. The sg mRNAs all possess a short 5′ common leader sequence, derived from the 5′ end of the genomic RNA. The joining of the non-contiguous ‘leader’ and ‘body’ sequences presumably occurs during minus-strand synthesis. To study whether toroviruses use a similar transcription mechanism, we characterized the 5′ termini of the genome and the four sg mRNAs of Berne virus (BEV). We show that BEV mRNAs 3–5 lack a leader sequence. Surprisingly, however, RNA 2 does contain a leader, identical to the 5′-terminal 18 residues of the genome. Apparently, BEV combines discontinuous and non-discontinous RNA synthesis to produce its sg mRNAs. Our findings have important implications for the understanding of the mechanism and evolution of nidovirus transcription.

Tags: berne-virus, nidovirus-transcription, nih, rna-recombination, subgenomic-rna
Organization: U.S. Department of Health & Human Services
Compound 525436: 3,5-Dithianonane

Chemical compound data from PubChem database. IUPAC Name: 1-(ethylsulfanylmethylsulfanyl)butane. Molecular Formula: C7H16S2. Molecular Weight: 164.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Matrix metalloproteinases in lung biology

Despite much information on their catalytic properties and gene regulation, we actually know very little of what matrix metalloproteinases (MMPs) do in tissues. The catalytic activity of these enzymes has been implicated to function in normal lung biology by participating in branching morphogenesis, homeostasis, and repair, among other events. Overexpression of MMPs, however, has also been blamed for much of the tissue destruction associated with lung inflammation and disease. Beyond their role in the turnover and degradation of extracellular matrix proteins, MMPs also process, activate, and deactivate a variety of soluble factors, and seldom is it readily apparent by presence alone if a specific proteinase in an inflammatory setting is contributing to a reparative or disease process. An important goal of MMP research will be to identify the actual substrates upon which specific enzymes act. This information, in turn, will lead to a clearer understanding of how these extracellular proteinases function in lung development, repair, and disease.

Tags: lung-biology, lung-inflammation, matrix-metalloproteinases, nih, tissue-repair
Organization: U.S. Department of Health & Human Services
The PRC-barrel: a widespread, conserved domain shared by photosynthetic reaction center subunits and proteins of RNA metabolism

The PRC-H β-barrel domain, a distinct cytoplasmic β-barrel domain whose fold has no close structural relationship to any other well known β-barrel domain, is the prototype of a novel superfamily of protein domains approximately 80 residues long. This domian is a widespread, ancient domain that appears to have been recruited to a variety of biological systems, ranging from RNA processing to photosynthesis.

Tags: nih, photosynthesis, prc-barrel, protein-domains, rna-metabolism
Organization: U.S. Department of Health & Human Services
2014-2016 NSDUH State-Specific Substate Region Estimates and Maps

This report provides a guide to the development and presentation of 2014-2016 NSDUH substate estimates. A summary of the estimation methodology is included as well as sample sizes, response rates, and population estimates.

Tags: mental-health, nsduh, samhsa, state-estimates, substance-use
Organization: U.S. Department of Health & Human Services
Risk and Protective Factors Tables (Prevalence Estimates) - 3.1 to 3.25

These detailed tables present totals and prevalence estimates of risk and protective factors regarding substance use from the 2010 National Survey on Drug Use and Health (NSDUH). The factors include perceptions of 1) risk of substance use, 2) availability of substances, 3) parental disapproval of youth substance use, 4) peer substance use. They also include measures of delinquent behavior, religious involvement, exposure to prevention messages, and parental involvement. Results are provided by age group, gender, race/ethnicity, geographic area, and youth substance use behavior. Comparisons are made between 2010 and 2009.

Tags: nsduh-2010, protective-factors, samhsa, substance-use-risk, youth-drug-use
Organization: U.S. Department of Health & Human Services
2018-2019 National Survey on Drug Use and Health: Guide to State Tables and Summary of Small Area Estimation Methodology

This document provides information on the model-based small area estimates of substance use and mental disorders in states based on data from the combined 2018-2019 National Surveys on Drug Use and Health (NSDUHs).

Tags: mental-disorders, samhsa, small-area-estimation, state-level-data, substance-use
Organization: U.S. Department of Health & Human Services
2022 Uniform Reporting System (URS) Table For Tennessee

This is the 2022 Uniform Reporting System (URS) Output Tables for Tennessee. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-program, community-mental-health, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Report to Congress on the Effectiveness of CAPTA State Programs and Technical Assistance

This report to Congress provides an overview of how the 50 states, the District of Columbia, and the Commonwealth of Puerto Rico have targeted their Child Abuse Prevention and Treatment Act funds and how those choices evolve in response to ongoing assessments of state performance in ensuring the safety, permanency, and well-being of children and families involved in the child welfare system.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: abuse, assessment, policy, prevention, reporting
Organization: U.S. Department of Health & Human Services
IL-6 signaling by STAT3 participates in the change from hyperplasia to neoplasia in NRP-152 and NRP-154 rat prostatic epithelial cells

Background
          STAT3 phosphorylation is associated with the neoplastic state in many types of cancer, including prostate cancer. We investigated the role of IL-6 signaling and phosphorylation of STAT3 in 2 rat prostatic epithelial lines. NRP-152 and NRP-154 cells were derived from the same rat prostate, yet the NRP-152 cells are not tumorigenic while the NRP-154 cells are tumorigenic. These lines are believed to represent 2 of the stages in the development of prostate cancer, hyperplasia and neoplasia. Differences in signaling pathways should play a role in the 2 phenotypes, hyperplastic and neoplastic.
        
        
          Methods
          We looked at the phosphorylation state of STAT3 by intracellular flow cytometry, using phospho-specific antibodies to STAT3. We used the same method to examine IL-6 production by the cell lines. We also measured apoptosis by binding of fluorescent annexin V to the cells.
        
        
          Results
          Although both cells lines made IL-6 constitutively, phosphorylated-STAT3 was present in untreated NRP-154 cells, but not in NRP-152 cells. Treatment with dexamethasone inhibited the IL-6 production of NRP-152 cells, but enhanced that of NRP-154 cells. Treatment with the JAK2 inhibitor AG490 induced apoptosis in NRP-152, but not NRP-154 cells.
        
        
          Conclusions
          We conclude from these experiments that STAT3 activity plays a role in the phenotype of NRP-154 cell, but not NRP-152 cells. The significance of alternative IL-6 signaling pathways in the different phenotypes of the 2 cell lines is discussed.

Tags: cell-lines, il-6-signaling, nih, prostate-cancer, stat3-phosphorylation
Organization: U.S. Department of Health & Human Services