AndreaBozzo/ceres-open-data-index huggingface dataset:
Induction of apoptosis in rat peripheral blood lymphocytes by the
anticancer drug CI-994 (acetyldinaline)

Abstract
          CI-994 (acetyldinaline) is an investigational anticancer drug currently in clinical trials. In preclinical safety studies in rats and dogs, CI-994 resulted in significant toxicity to bone marrow and lymphoid tissue. To determine if apoptosis was involved in CI-994 toxicity, peripheral blood lymphocytes were
isolated from untreated male Wistar rats and exposed to CI-994 (1, 3, 10, or 30 μM) in vitro for up to 24 hours. Morphological and biochemical features of apoptosis were evaluated using several techniques, and lactate dehydrogenase (LDH) release was measured as an indicator of cell necrosis. No evidence of apoptosis or necrosis was detected in lymphocytes exposed to CI-994 for 4 hours. After 24 hours, concentration-dependent increases in apoptosis characterized by DNA condensation, DNA fragmentation, and/or externalization of phosphatidyl serine were seen at CI-994 concentrations as low as 1 μM and were statistically significant beginning at 10 μM. Ultrastructural analysis confirmed the presence of DNA condensation, DNA fragmentation, cell shrinkage, and membrane blebbing in cells exposed to 30 μM CI-994. After 24 hours, the percent of maximum LDH release from lymphocytes treated with 10 and 30 μM CI-994 was 7% and 15%, respectively, compared with 0% in the controls. In comparison, morphological changes of apoptosis detected by fluorescent microscopy were observed in 79% of the lymphocytes at these two concentrations. Additionally, apoptosis was seen in more than 24% of lymphocytes exposed to 1 and 3 μM CI-994, whereas maximum LDH release was less than or equal to 1% at these concentrations. These results show that apoptosis is the primary mode of cell death in rat lymphocytes exposed to CI-994 in vitro.

Tags: apoptosis-induction, ci-994-toxicity, lymphocyte-toxicity, nih, rat-lymphocytes
Organization: U.S. Department of Health & Human Services
Compound 527270: Lavandulyl isobutyrate

Chemical compound data from PubChem database. IUPAC Name: (5-methyl-2-prop-1-en-2-ylhex-4-enyl) 2-methylpropanoate. Molecular Formula: C14H24O2. Molecular Weight: 224.34. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 525501: 6,6-Dimethyl-4,5-dithia-1-heptene

Chemical compound data from PubChem database. IUPAC Name: 2-methyl-2-(prop-2-enyldisulfanyl)propane. Molecular Formula: C7H14S2. Molecular Weight: 162.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2023 Uniform Reporting System (URS) Table For Hawaii

This is the 2023 Uniform Reporting System (URS) Output Tables for Hawaii. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, hawaii-mental-health, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Compound 528557: Octadecane, 7-ethyl

Chemical compound data from PubChem database. IUPAC Name: 7-ethyloctadecane. Molecular Formula: C20H42. Molecular Weight: 282.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2010 State Profile — Rhode Island

This state profile includes data from facilities in Rhode Island that reported to N-SSATS for the survey reference date March 31, 2010. Data were collected on the location, characteristics, services offered, and number of clients in treatment at alcohol and drug abuse treatment facilities (both public and private) in Rhode Island. In Rhode Island, 53 substance abuse treatment facilities were included in the 2010 N-SSATS, reporting that there were 7,362 clients in substance abuse treatment on March 31, 2010. The survey response rate in Rhode Island was 87.1%.

Tags: addiction-services, n-ssats, rhode-island, samhsa, substance-abuse-treatment
Organization: U.S. Department of Health & Human Services
Title IV-E Development Grants

Standing Announcement for Tribal Title IV-E Plan Development Grants - These grants are funded via a standing funding opportunity announcement (SFOA), which means that the same announcement (with minor modifications) is published each year. To view published and archived SFOAs, visit Grants.gov
  
  

. Each year a new group of Tribal Title IV-E Plan Development grants is awarded. Information about which applicants received awards can be found on the Children's Bureau website.

The purpose of the Standing Announcement for Tribal Title IV-E Plan Development Grants is to make one-time grants to tribes, tribal organizations, or tribal consortia that are seeking to develop and, within 24 months of grant receipt, submit to the U.S. Department of Health and Human Services a plan to implement a title IV-E foster care, adoption assistance, and, at tribal option, guardianship assistance program. Grant funds under this announcement may be used for the cost of developing a title IV-E plan under section 471 of the Social Security Act (the Act) to carry out a program under section 479B of the Act. The grant may be used for costs relating to the development of data-collection systems, a cost-allocation methodology, agency and tribal court procedures necessary to meet the case-review system requirements under Section 475(5) of the Act, or any other costs attributable to meeting any other requirement necessary for approval of a title IV-E plan.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: child, fiscal, grant, policy, scope
Organization: U.S. Department of Health & Human Services
Development of porcine embryos reconstituted with somatic cells and enucleated metaphase I and II oocytes matured in a protein-free medium

Background
          Many cloned animals have been created by transfer of differentiated cells at G0/G1 or M phase of the cell cycle into enucleated M II oocytes having high maturation/meiosis/mitosis-promoting factor activity. Because maturation/meiosis/mitosis-promoting factor activity during oocyte maturation is maximal at both M I and M II, M I oocytes may reprogram differentiated cell nuclei as well. The present study was conducted to examine the developmental ability in vitro of porcine embryos reconstructed by transferring somatic cells (ear fibroblasts) into enucleated M I or M II oocytes.
        
        
          Results
          Analysis of the cell cycle stages revealed that 91.2 ± 0.2% of confluent cells were at the G0/G1 phase and 54.1 ± 4.4% of nocodazole-treated cells were at the G2/M phase, respectively. At 6 h after activation, nuclear swelling was observed in 50.0-88.9% and 34.4-39.5% of embryos reconstituted with confluent cells and nocodazole-treated cells regardless of the recipient oocytes, respectively. The incidence of both a swollen nucleus and polar body was low (6.3-10.5%) for all nocodazole-treated donor cell regardless of the recipient oocyte. When embryos reconstituted with confluent cells and M I oocytes were cultured, 2 (1.5%) blastocysts were obtained and this was significantly (P < 0.05) lower than that (7.6%) of embryos produced by transferring confluent cells into M II oocytes. No reconstructed embryos developed to the blastocyst stage when nocodazole-treated cells were used as donors.
        
        
          Conclusions
          Porcine M I oocytes have a potential to develop into blastocysts after nuclear transfer of somatic cells.

Tags: animal-cloning, nih, oocyte-maturation, porcine-embryos, somatic-cell-transfer
Organization: U.S. Department of Health & Human Services
Compound 525586: N,N-Dimethyl-N'-(4-bromophenyl)-benzamidine

Chemical compound data from PubChem database. IUPAC Name: N'-(4-bromophenyl)-N,N-dimethylbenzenecarboximidamide. Molecular Formula: C15H15BrN2. Molecular Weight: 303.2. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 525481: 4-Methyl-3-thia-1-pentanethiol

Chemical compound data from PubChem database. IUPAC Name: 2-propan-2-ylsulfanylethanethiol. Molecular Formula: C5H12S2. Molecular Weight: 136.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Title IV-E Reviews — Peer Reviewer Qualifications

The Children’s Bureau conducts the Title IV-E Foster Care Eligibility Reviews (IV-E Reviews) to monitor Title IV-E agencies’ compliance with federally mandated requirements under Title IV, Part E, of the Social Security Act. To that end, a IV-E Review team, which may include Peer Reviewers, conducts case record reviews using the Title IV-E Foster Care Eligibility On-Site Review Instrument and Instructions. (Peer Reviewers are not used for every IV-E Review. The Children's Bureau may use up to two Peer Reviewers for a primary review and up to four Peer Reviewers for a secondary review.)

Peer Reviewers are Title IV-E experts who can make individual professional judgments regarding initial and ongoing eligibility for Title IV-E programs. They perform this work as participants in the IV-E Reviews. Peer Reviewers must have extensive knowledge of Title IV-E eligibility criteria. The qualifications for individuals interested in participating as Peer Reviewers include:

We encourage applications from bilingual and Spanish-speaking persons, and those with experience working in Tribal child welfare programs.

For more information on becoming a Peer Reviewer in the IV-E Reviews, please contact the Child Welfare Compliance Reviews Team at JBS International, Inc. (See Title IV-E Foster Care Eligibility Reviews Peer Reviewer Information page to contact)

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: assessment, care, compliance, foster, policy
Organization: U.S. Department of Health & Human Services
National Directory of Drug and Alcohol Abuse Treatment Facilities 2014

The National Directory of Drug and Alcohol Abuse Treatment Programs 2014 lists federal, state, local, and private facilities that provide substance abuse treatment services. The directory includes treatment facilities that are licensed, certified, or otherwise approved for inclusion in the directory by their state substance abuse agencies and that responded to the 2013 National Survey of Substance Abuse Treatment Services (N-SSATS). The information about each facility that appears in this directory was provided by that facility in response to the 2013 N-SSATS. The Substance Abuse and Mental Health Services Administration (SAMHSA) conducts the N-SSATS annually.

Tags: alcohol-abuse, drug-abuse, samhsa, substance-abuse-treatment, treatment-facilities
Organization: U.S. Department of Health & Human Services
2017 Uniform Reporting System (URS) Table for Virginia

This is the 2017 Uniform Reporting System (URS) Output Tables for Virginia. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-program, mental-health-services, national-outcome-measures, samhsa, virginia
Organization: U.S. Department of Health & Human Services
Mental Health Client-Level Data (MH-CLD) 2022: Data On Clients Receiving Mental Health Treatment Services Through State Mental Health Agencies

This report describes the total number of clients receiving mental health treatment services in 2022 by demographics, National Outcome Measures (NOMs) and the top five mental health diagnoses for children (ages 0 - 17) and adults (18 and older) by geographical distribution. This report also includes client characteristics and the top 5 mental health diagnoses among all clients receiving mental health treatment services for the 2018-2022 MH-CLD reporting periods. The NOMs presented in this report include stability in housing/residential status, adult employment, and access to services/capacity.

Tags: client-level-data, mental-health-diagnoses, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Trends in Substance Use Disorders among Males Aged 18 to 49 on Probation or Parole

This National Survey on Drug Use and Health (NSDUH) short report looks at trends in substance use disorder (SUD) among males aged 18 to 49 on probation or parole during the past 12 months. The report looks those who had an alcohol or illicit drug use disorder, or both, in the past year.

Tags: alcohol-drug-use, mens-health, probation-parole, samhsa, substance-use-disorder
Organization: U.S. Department of Health & Human Services
Selection in the evolution of gene duplications

Background
          Gene duplications have a major role in the evolution of new biological functions. Theoretical studies often assume that a duplication per se is selectively neutral and that, following a duplication, one of the gene copies is freed from purifying (stabilizing) selection, which creates the potential for evolution of a new function.
        
        
          Results
          In search of systematic evidence of accelerated evolution after duplication, we used data from 26 bacterial, six archaeal, and seven eukaryotic genomes to compare the mode and strength of selection acting on recently duplicated genes (paralogs) and on similarly diverged, unduplicated orthologous genes in different species. We find that the ratio of nonsynonymous to synonymous substitutions (Kn/Ks) in most paralogous pairs is <<1 and that paralogs typically evolve at similar rates, without significant asymmetry, indicating that both paralogs produced by a duplication are subject to purifying selection. This selection is, however, substantially weaker than the purifying selection affecting unduplicated orthologs that have diverged to the same extent as the analyzed paralogs. Most of the recently duplicated genes appear to be involved in various forms of environmental response; in particular, many of them encode membrane and secreted proteins.
        
        
          Conclusions
          The results of this analysis indicate that recently duplicated paralogs evolve faster than orthologs with the same level of divergence and similar functions, but apparently do not experience a phase of neutral evolution. We hypothesize that gene duplications that persist in an evolving lineage are beneficial from the time of their origin, due primarily to a protein dosage effect in response to variable environmental conditions; duplications are likely to give rise to new functions at a later phase of their evolution once a higher level of divergence is reached.

Tags: gene-duplication, genomic-data, molecular-evolution, natural-selection, nih
Organization: U.S. Department of Health & Human Services
A role of proton transfer in peroxidase-catalyzed process elucidated by substrates docking calculations

Background
          Previous kinetic investigations of fungal-peroxidase catalyzed oxidation of N-aryl hydroxamic acids (AHAs) and N-aryl-N-hydroxy urethanes (AHUs) revealed that the rate of reaction was independent of the formal redox potential of substrates. Moreover, the oxidation rate was 3–5 orders of magnitude less than for oxidation of physiological phenol substrates, though the redox potential was similar.
        
        
          Results
          To explain the unexpectedly low reactivity of AHAs and AHUs we made ab initio calculations of the molecular structure of the substrates following in silico docking in the active center of the enzyme.
        
        
          Conclusions
          AHAs and AHUs were docked at the distal side of heme in the sites formed by hydrophobic amino acid residues that retarded a proton transfer and finally the oxidation rate. The analogous phenol substrates were docked at different sites permitting fast proton transfer in the relay of distal His and water that helped fast substrate oxidation.

Tags: enzyme-kinetics, molecular-docking, nih, peroxidase-catalysis, proton-transfer
Organization: U.S. Department of Health & Human Services
Comparison of 2002-2003 and 2011-2012 NSDUH State Prevalence Estimates

This report presents trends of estimates for measures of substance use and mental health based on the combined 2002 and 2003 and the combined 2011 and 2012 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: mental-health, nsduh-survey, samhsa, state-prevalence, substance-use
Organization: U.S. Department of Health & Human Services
2010-2012 NSDUH Guide to Substate Tables and Summary of Small Area Estimation Methodology

This report discusses the methodology used in the 2010 to 2012 National Survey on Drug Use and Health (NSDUH) report that assesses past year alcohol use disorder and illicit drug use disorder among persons aged 12 or older by 362 substate regions within the 50 States and the District of Columbia. Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE).

Tags: alcohol-use-disorder, mental-health-indicators, samhsa, small-area-estimation, substance-use-disorder
Organization: U.S. Department of Health & Human Services
2011 CMHS Uniform Reporting System (URS) Output Tables for Mississippi

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2011. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, national-outcome-measures, samhsa, urs-data
Organization: U.S. Department of Health & Human Services
Compound 525688: Pentafluoropropionic acid, tetradecyl ester

Chemical compound data from PubChem database. IUPAC Name: tetradecyl 2,2,3,3,3-pentafluoropropanoate. Molecular Formula: C17H29F5O2. Molecular Weight: 360.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 525627: N,N-Dimethyl-N'-heptyl-p-chlorobenzamidine

Chemical compound data from PubChem database. IUPAC Name: 4-chloro-N'-heptyl-N,N-dimethylbenzenecarboximidamide. Molecular Formula: C16H25ClN2. Molecular Weight: 280.83. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
National Directory of Drug and Alcohol Abuse Treatment Facilities 2006

The National Directory of Drug and Alcohol Abuse Treatment Programs 2006 lists federal, state, local, and private facilities that provide substance abuse treatment services. The directory includes treatment facilities that are licensed, certified, or otherwise approved for inclusion in the directory by their state substance abuse agencies and that responded to the 2005 National Survey of Substance Abuse Treatment Services (N-SSATS). The information about each facility that appears in this directory was provided by that facility in response to the 2005 N-SSATS. The Substance Abuse and Mental Health Services Administration (SAMHSA) conducts the N-SSATS annually.

Tags: alcohol-abuse-treatment, n-ssats, samhsa, substance-abuse-treatment, treatment-facility-directory
Organization: U.S. Department of Health & Human Services
Systematic assessment of the quality of osteoporosis guidelines

Background
          Numerous agencies have developed clinical practice guidelines for the management of postmenopausal osteoporosis. The study objective was to conduct a systematic assessment of the quality of osteoporosis guidelines produced since 1998.
        
        
          Methods
          Guidelines were identified by searching MEDLINE (1998+), the world wide web, known guideline developer websites, bibliographies of retrieved guidelines, and through consultation with content experts. Each guideline was then assessed by three independent appraisers using the 'Appraisal Instrument for Clinical Guidelines' (version 1) by Cluzeau.
        
        
          Results
          We identified 26 unique guidelines from 1998–2001 and 21 met our inclusion criteria. Of the 21 guidelines reviewed, 8 were developed by medical societies, 6 by national groups, 6 by government agencies, and 1 by an international group. Twelve of the guidelines were published, 7 were organizational reports, and 2 were accessible only from the web. Half or more of the 20 items assessing the rigor of guideline development were met by 15% (median quality score 23%, range 5–80%, (95% CI 16.5, 34.7)), 81% met at least half of the 12 items assessing guideline content and context (median score 58%, range 17–83%, (95% CI 50.8, 65.5)), and none met half or more of the items assessing guideline application (median score 0%, range 0–47%, (95% CI -0.5 to 12.6)). Eight guidelines described the method used to assess the strength of evidence, and in 6 there was an explicit link between recommendations and the supporting evidence. Ten guidelines were judged not suitable for use in practice, 10 were acceptable with modification, and one was acceptable for use without modification.
        
        
          Conclusion
          The methodological quality of current osteoporosis guidelines is low, although their scores for clinical content were higher. Virtually no guidelines covered dissemination issues. Few guidelines were judged as acceptable for use in their current format.

Tags: clinical-guideline-assessment, guideline-quality, nih, osteoporosis-guidelines, postmenopausal-osteoporosis
Organization: U.S. Department of Health & Human Services