AndreaBozzo/ceres-open-data-index huggingface dataset:
Schedule-selective biochemical modulation of 5-fluorouracil in advanced colorectal cancer – a phase II study

Background
          5-fluorouracil remains the standard therapy for patients with advanced/metastatic colorectal cancer. Pre-clinical studies have demonstrated the biological modulation of 5-fluorouracil by methotrexate and leucovorin. This phase II study was initiated to determine the activity and toxicity of sequential methotrexate – leucovorin and 5-fluorouracil chemotherapy in patients with advanced colorectal cancer.
        
        
          Methods
          Ninety-seven patients with metastatic colorectal cancer were enrolled onto the study. Methotrexate – 30 mg/m2 was administered every 6 hours for 6 doses followed by a 2 hour infusion of LV – 500 mg/m2. Midway through the leucovorin infusion, patients received 5-fluorouracil – 600 mg/m2. This constituted a cycle of therapy and was repeated every 2 weeks until progression.
        
        
          Results
          The median age was 64 yrs (34–84) and the Eastern Cooperative Group Oncology performance score was 0 in 37%, 1 in 55% and 2 in 8% of patients. Partial and complete responses were seen in 31% of patients with a median duration of response of 6.4 months. The overall median survival was 13.0 months. The estimated 1-year survival was 53.7%. Grade III and IV toxic effects were modest and included mucositis, nausea and vomiting.
          
            Conclusions
            This phase II study supports previously reported data demonstrating the modest clinical benefit of 5-FU modulation utilizing methotrexate and leucovorin in patients with metastatic colorectal cancer. Ongoing studies evaluating 5-fluorouracil modulation with more novel agents (Irinotecan and/or oxaliplatin) are in progress and may prove encouraging.

Tags: 5-fluorouracil, biochemical-modulation, colorectal-cancer, methotrexate-leucovorin, nih
Organization: U.S. Department of Health & Human Services
NSDUH 2022 Pill Images for the NSDUH Questionnaire

This report contains the pill images used in the audio computer-assisted self-interviewing (ACASI) portion of the NSDUH questionnaire. These images are copyrighted and may not be reproduced. The owner of the copyright is SFI Medical Publishing of Lawrence, Kansas.

Tags: nsduh-questionnaire, pill-identification, prescription-drugs, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Montana, 2014

This is a behavioral health report for the state of Montana. It uses the  National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment Services (NSSATS) to address the topics of youth substance use , youth mental health and treatment, adult mental health and treatment, substance use, substance use treatment, and medicare enrollees for the years 2009 to 2013.

Tags: adult-mental-health, montana-behavioral-health, samhsa, substance-use-treatment, youth-substance-use
Organization: U.S. Department of Health & Human Services
Compound 525585: N,N-Dimethyl-N'-(3-nitrophenyl)-p-methylbenzamidine

Chemical compound data from PubChem database. IUPAC Name: N,N,4-trimethyl-N'-(3-nitrophenyl)benzenecarboximidamide. Molecular Formula: C16H17N3O2. Molecular Weight: 283.32. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2010 CMHS Uniform Reporting System (URS) Output Tables for Mississippi

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2010. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, mississippi-mental-health, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
A simple model based on mutation and selection explains trends in codon and amino-acid usage and GC composition within and across genomes

Background:
          Correlations between genome composition (in terms of GC content) and usage of particular codons and amino acids have been widely reported, but poorly explained. We show here that a simple model of processes acting at the nucleotide level explains codon usage across a large sample of species (311 bacteria, 28 archaea and 257 eukaryotes). The model quantitatively predicts responses (slope and intercept of the regression line on genome GC content) of individual codons and amino acids to genome composition.
        
        
          Results:
          Codons respond to genome composition on the basis of their GC content relative to their synonyms (explaining 71-87% of the variance in response among the different codons, depending on measure). Amino-acid responses are determined by the mean GC content of their codons (explaining 71-79% of the variance). Similar trends hold for genes within a genome. Position-dependent selection for error minimization explains why individual bases respond differently to directional mutation pressure.
        
        
          Conclusions:
          Our model suggests that GC content drives codon usage (rather than the converse). It unifies a large body of empirical evidence concerning relationships between GC content and amino-acid or codon usage in disparate systems. The relationship between GC content and codon and amino-acid usage is ahistorical; it is replicated independently in the three domains of living organisms, reinforcing the idea that genes and genomes at mutation/selection equilibrium reproduce a unique relationship between nucleic acid and protein composition. Thus, the model may be useful in predicting amino-acid or nucleotide sequences in poorly characterized taxa.

Tags: amino-acid-usage, codon-usage, gc-content, genome-composition, nih
Organization: U.S. Department of Health & Human Services
Compound 525470: 4,6-Dithia-1,8-nonadiene

Chemical compound data from PubChem database. IUPAC Name: 3-(prop-2-enylsulfanylmethylsulfanyl)prop-1-ene. Molecular Formula: C7H12S2. Molecular Weight: 160.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Superantigen antagonist peptides

The production of superantigenic exotoxins by Gram positive bacteria underlies the pathology of toxic shock syndrome. Future treatment strategies for superantigen-mediated diseases are likely to be directed at blocking the three-way interaction between superantigen, T cell receptor and major histocompatibility class II molecule, which inititates an excessive and disordered inflammatory response. In this article, we review the first published data to address one such strategy in the context of other recognised and experimental treatments.

Tags: gram-positive-bacteria, inflammatory-response, nih, superantigen-antagonists, toxic-shock-syndrome
Organization: U.S. Department of Health & Human Services
2018-2020 NSDUH Substate Region Estimates - Tables

Substate estimates for these years are no longer available due to methodological concerns with combining 2020 data with data from 2018 and 2019. We apologize for any inconvenience or confusion this may cause.Because of the COVID-19 pandemic, most respondents answered the survey via the web in Quarter 4 of 2020, even though all responses in Quarter 1 were from in-person interviews. It is known that people may respond to the survey differently while taking it online, thus introducing what is called a mode effect.When the state estimates were released, it was assumed that the mode effect was similar for different groups of people. However, later analyses have shown that this assumption should not be made. Because of these analyses, along with concerns about the rapid societal changes in 2020, it was determined that averages across the three years could be misleading.For more detail on this decision, see the 2018-2020substate data page.

Tags: mental-health, nsduh, samhsa, substance-use, survey-data
Organization: U.S. Department of Health & Human Services
Compound 525317: Trimethylsilyl-L(+)rhamnose

Chemical compound data from PubChem database. IUPAC Name: trimethyl-[2-methyl-3,5,6-tris(trimethylsilyloxy)oxan-4-yl]oxysilane. Molecular Formula: C18H44O5Si4. Molecular Weight: 452.9. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Table 27. Had at Least One Major Depressive Episode in the Past Year among Persons Aged 18 or Older, by State and Substate Regions: Percentages, Annual Averages Based on 2010, 2011, and 2012 NSDUHs

Table 27. Had at Least One Major Depressive Episode in the Past Year among Persons Aged 18 or Older, by State and Substate Regions: Percentages, Annual Averages Based on 2010, 2011, and 2012 NSDUHs

Tags: adult-depression, major-depressive-episode, mental-health, nsduh-data, samhsa
Organization: U.S. Department of Health & Human Services
Request for Public Comment and Consultation Meetings on AFCARS

Request for Public Comment and Consultation Meetings on AFCARS
  
  

 (PDF) - This is a Federal Register notice titled "Request for Public Comment and Consultation Meetings on the Adoption and Foster Care Analysis and Reporting System (AFCARS)."

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: adoption, care, foster, policy, reporting
Organization: U.S. Department of Health & Human Services
2022 Uniform Reporting System (URS) Table For North Dakota

This is the 2022 Uniform Reporting System (URS) Output Tables for North Dakota. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-data, mental-health-services, noms-measures, north-dakota, samhsa
Organization: U.S. Department of Health & Human Services
Boston: Drug-Related Emergency Department Visits, 2004-2011 - Accidental Ingestions

Excel file with estimates, rates, relative standard errors, trends and confidence intervals, covering 2004-2011 for emergency department visits involving accidental ingestions in the Boston metropolitan area. This analytic category includes ED visits in which an individual accidentally or unknowingly used or was administered a prescription drug, over-the-counter medication, or dietary supplement. Drug-related accidental ingestion typically involves patients aged 5 and under.  This analytic category does not include drug misuse or abuse.File includes data for over 500 drugs, including illicit drugs, prescription and over-the-counter medications, dietary supplements, inhalants and alcohol.  Includes total visits, gender, age group, race/ethnicity, outcome of visit, drug combinations, number of drugs involved in visit, drug frequency, and drugs confirmed by toxicology.Additional detail is provided for illicit drugs, psychotherapeutic drugs, central nervous system (CNS) drugs, respiratory drugs and cardiovascular drugs.

Tags: accidental-ingestion, drug-overdose, emergency-department, pediatric-poisoning, samhsa
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Kansas, 2013

This is a behavioral health report for the state of Kansas. It uses the  National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment Services (NSSATS) to address the topics of youth substance use , youth mental health and treatment, adult mental health and treatment, substance use, substance use treatment for the years 2008 to 2012.

Tags: adult-mental-health, kansas-behavioral-health, samhsa, substance-use-treatment, youth-substance-use
Organization: U.S. Department of Health & Human Services
2020 Uniform Reporting System (URS) Table For Delaware

This is the 2020 Uniform Reporting System (URS) Output Tables for Delaware. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-program, mental-health-services, national-outcome-measures, samhsa, services
Organization: U.S. Department of Health & Human Services
A regulator of G Protein signaling, RGS3, inhibits gonadotropin-releasing hormone (GnRH)-stimulated luteinizing hormone (LH) secretion

Background
          Luteinizing hormone secreted by the anterior pituitary gland regulates gonadal function. Luteinizing hormone secretion is regulated both by alterations in gonadotrope responsiveness to hypothalamic gonadotropin releasing hormone and by alterations in gonadotropin releasing hormone secretion. The mechanisms that determine gonadotrope responsiveness are unknown but may involve regulators of G protein signaling (RGSs). These proteins act by antagonizing or abbreviating interaction of Gα proteins with effectors such as phospholipase Cβ. Previously, we reported that gonadotropin releasing hormone-stimulated second messenger inositol trisphosphate production was inhibited when RGS3 and gonadotropin releasing hormone receptor cDNAs were co-transfected into the COS cell line. Here, we present evidence for RGS3 inhibition of gonadotropin releasing hormone-induced luteinizing hormone secretion from cultured rat pituitary cells.
        
        
          Results
          A truncated version of RGS3 (RGS3T = RGS3 314–519) inhibited gonadotropin releasing hormone-stimulated inositol trisphosphate production more potently than did RSG3 in gonadotropin releasing hormone receptor-bearing COS cells. An RSG3/glutathione-S-transferase fusion protein bound more 35S-Gqα than any other member of the G protein family tested. Adenoviral-mediated RGS3 gene transfer in pituitary gonadotropes inhibited gonadotropin releasing hormone-stimulated luteinizing hormone secretion in a dose-related fashion. Adeno-RGS3 also inhibited gonadotropin releasing hormone stimulated 3H-inositol phosphate accumulation, consistent with a molecular site of action at the Gqα protein.
        
        
          Conclusions
          RGS3 inhibits gonadotropin releasing hormone-stimulated second messenger production (inositol trisphosphate) as well as luteinizing hormone secretion from rat pituitary gonadotropes apparently by binding and suppressing the transduction properties of Gqα protein function. A version of RGS3 that is amino-terminally truncated is even more potent than intact RGS3 at inhibiting gonadotropin releasing hormone-stimulated inositol trisphosphate production.

Tags: gonadotropin-releasing-hormone, luteinizing-hormone, nih, pituitary-cells, rgs3-protein
Organization: U.S. Department of Health & Human Services
Dr. Elinore F. McCance-Katz, Urgent and Emerging Issues in Prevention: Marijuana, Kratom, E-cigarettes

SAMHSA Prevention Day, February 4, 2019 Elinore F. McCance-Katz, MD, PhD, Assistant Secretary for Mental Health and Substance Use, Substance Abuse and Mental Health Services Administration, Department of Health and Human ServicesView therecorded presentation(link is external)and webcast slides (PDF,PPTX) presented by Dr. Elinore F. McCance-Katz.

Tags: e-cigarette-use, kratom-use, marijuana-use, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
New Hampshire (NH)

This report uses 2008 to 2010 National Survey on Drug Use and Health (NSDUH) to assess past year alcohol use disorder and illicit drug use disorder among persons aged 12 or older for New Hampshire overall and for substate regions within New Hampshire. Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE).

Tags: alcohol-use-disorder, mental-health-nh, nh-survey, samhsa, substance-use-disorder
Organization: U.S. Department of Health & Human Services
Pennsylvania: 2011-2012 NSDUH

This report presents Pennsylvania\'s estimates for 25 measures of substance use and mental health based on the combined 2011 and 2012 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided by State and for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: mental-health, nsduh-survey, pennsylvania, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
A Report to Congress on Barriers and Success Factors in Adoptions from Foster Care: Perspectives of Families and Staff Supported by the Adoption Opportunities Program

This report outlines the findings of two adoption-research studies conducted as part of The Collaboration to AdoptUsKids. The studies identified the child, family, and agency factors that presented as barriers or promoters of successful adoptions from foster care.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: adoption, assessment, foster, policy, reporting
Organization: U.S. Department of Health & Human Services
Incidence Tables (Standard Errors and P Values) - 4.1 to 4.16

These detailed tables present standard errors for totals and prevalence estimates of substance use initiation from the 2010 National Survey on Drug Use and Health (NSDUH). Substances examined include illicit drugs (e.g., marijuana, cocaine, heroin, hallucinogens (including LSD, PCP, Ecstasy), inhalants, and the nonmedical use of prescription-type pain relievers (including OxyContin), tranquilizers, stimulants, sedatives, alcohol, and tobacco products (including cigarettes, smokeless tobacco, and cigars). Standard errors are provided by age group and gender. Standard errors are provided for both 2010 and 2009.

Tags: nsduh-data, prevalence-estimates, samhsa, standard-errors, substance-use-initiation
Organization: U.S. Department of Health & Human Services
Intraocular pressure in genetically distinct mice: an update and strain survey

Background
          Little is known about genetic factors affecting intraocular pressure (IOP) in mice and other mammals. The purpose of this study was to determine the IOPs of genetically distinct mouse strains, assess the effects of factors such as age, sex and time of day on IOP in specific strain backgrounds, and to assess the effects of specific candidate gene mutations on IOP.
        
        
          Results
          Based on over 30 studied mouse strains, average IOP ranges from approximately 10 to 20 mmHg. Gender does not typically affect IOP and aging results in an IOP decrease in some strains. Most tested strains exhibit a diurnal rhythm with IOP being the highest during the dark period of the day. Homozygosity for a null allele of the carbonic anhydrase II gene (Car2n) does not alter IOP while homozygosity for a mutation in the leptin receptor gene (Leprdb) that causes obesity and diabetes results in increased IOP. Albino C57BL/6J mice homozygous for a tyrosinase mutation (Tyrc-2J) have higher IOPs than their pigmented counterparts.
        
        
          Conclusions
          Genetically distinct mouse strains housed in the same environment have a broad range of IOPs. These IOP differences are likely due to interstrain genetic differences that create a powerful resource for studying the regulation of IOP. Age, time of day, obesity and diabetes have effects on mouse IOP similar to those in humans and other species. Mutations in two of the assessed candidate genes (Lepr and Tyr) result in increased IOP. These studies demonstrate that mice are a practical and powerful experimental system to study the genetics of IOP regulation and disease processes that raise IOP to harmful levels.

Tags: diurnal-rhythm, glaucoma-research, intraocular-pressure, mouse-strains, nih
Organization: U.S. Department of Health & Human Services
2010 CMHS Uniform Reporting System (URS) Output Tables for Washington, DC

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2010. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, national-outcome-measures, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
Compound 525565: N,N-Dimethyl-N'-(3-chlorophenyl)-benzamidine

Chemical compound data from PubChem database. IUPAC Name: N'-(3-chlorophenyl)-N,N-dimethylbenzenecarboximidamide. Molecular Formula: C15H15ClN2. Molecular Weight: 258.74. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Treatment Episode Data Set (TEDS) 1994-2004 National Admissions to Substance Abuse Treatment Services

This report presents results from the Treatment Episode Data Set (TEDS) for 2004 and trend data for 1994-2004. The report provides information on the demographic and substance abuse characteristics of the 1.9 million people admitted to treatment for abuse of alcohol and drugs in 2004 to facilities that report to individual state administrative data systems.

Tags: alcohol-drug-abuse, samhsa, substance-abuse-treatment, teds-admissions, treatment-episodes
Organization: U.S. Department of Health & Human Services
Hawaii: 2011-2012 NSDUH

This report presents Hawaii\'s estimates for 25 measures of substance use and mental health based on the combined 2011 and 2012 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided by State and for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: hawaii, mental-health, nsduh-data, samhsa, substance-use
Organization: U.S. Department of Health & Human Services