AndreaBozzo/ceres-open-data-index huggingface dataset:
Lipoprotein profile in older patients with vascular dementia and Alzheimer's disease

Background
          Some alterations of the lipoprotein profile have been associated with cerebrovascular disease. Recently, it has been suggested that cerebrovascular disease might play a role in the pathogenesis of both vascular dementia (VD) and Alzheimer's disease (AD). Nevertheless, the possible association of dyslipidemias with VD or AD is still a controversial issue.
        
        
          Methods
          We investigated the lipoprotein profile in 100 older patients with vascular dementia (VD; n°: 60) or Late Onset Alzheimer's Disease (LOAD; n°: 40). The patients were compared with 54 community dwelling non-demented older controls.
        
        
          Results
          After adjustment for functional status, blood sedimentation rate, and serum albumin levels, no differences in lipoprotein profile emerged between the three groups, with the exception of HDL-C that was lower in VD compared with controls. Low HDL-C (< 45 mg/dL) was associated with VD (O.R.: 6.52, C.I. 95%: 1.42–30.70 vs controls, and 4.31, C.I. 95%: 0.93–19.82 vs LOAD), after multivariate adjustment. No differences in plasma lipid levels emerged between the three groups after stratification for apo E4 genotype.
        
        
          Conclusions
          In this cross-sectional study low HDL-C levels are associated with VD, but not with LOAD, in a sample of older subjects.

Tags: alzheimers-disease, hdl-cholesterol, lipoprotein-profile, nih, vascular-dementia
Organization: U.S. Department of Health & Human Services
Combinatorial diversity of fission yeast SCF ubiquitin ligases by homo- and heterooligomeric assemblies of the F-box proteins Pop1p and Pop2p

Background
          SCF ubiquitin ligases share the core subunits cullin 1, SKP1, and HRT1/RBX1/ROC1, which associate with different F-box proteins. F-box proteins bind substrates following their phosphorylation upon stimulation of various signaling pathways. Ubiquitin-mediated destruction of the fission yeast cyclin-dependent kinase inhibitor Rum1p depends on two heterooligomerizing F-box proteins, Pop1p and Pop2p. Both proteins interact with the cullin Pcu1p when overexpressed, but it is unknown whether this reflects their co-assembly into bona fide SCF complexes.
        
        
          Results
          We have identified Psh1p and Pip1p, the fission yeast homologues of human SKP1 and HRT1/RBX1/ROC1, and show that both associate with Pop1p, Pop2p, and Pcu1p into a ~500 kDa SCFPop1p-Pop2p complex, which supports polyubiquitylation of Rum1p. Only the F-box of Pop1p is required for SCFPop1p-Pop2p function, while Pop2p seems to be attracted into the complex through binding to Pop1p. Since all SCFPop1p-Pop2p subunits, except for Pop1p, which is exclusively nuclear, localize to both the nucleus and the cytoplasm, the F-box of Pop2p may be critical for the assembly of cytoplasmic SCFPop2p complexes. In support of this notion, we demonstrate individual SCFPop1p and SCFPop2p complexes bearing ubiquitin ligase activity.
        
        
          Conclusion
          Our data suggest that distinct homo- and heterooligomeric assemblies of Pop1p and Pop2p generate combinatorial diversity of SCFPop function in fission yeast. Whereas a heterooligomeric SCFPop1p-Pop2p complex mediates polyubiquitylation of Rum1p, homooligomeric SCFPop1p and SCFPop2p complexes may target unknown nuclear and cytoplasmic substrates.

Tags: fission-yeast, nih, protein-interactions, rum1p-regulation, ubiquitin-ligases
Organization: U.S. Department of Health & Human Services
The cloning, genomic organization and tissue expression profile of the human  DLG5 gene

Background
          Familial atrial fibrillation, an autosomal dominant disease, was previously mapped to chromosome 10q22. One of the genes mapped to the 10q22 region is DLG5, a member of the MAGUKs (Membrane Associated Gyanylate Kinase) family which mediates intracellular signaling. Only a partial cDNA was available for DLG5. To exclude potential disease inducing mutations, it was necessary to obtain a complete cDNA and genomic sequence of the gene.
        
        
          Methods
          The Northern Blot analysis performed using 3' UTR of this gene indicated the transcript size to be about 7.2 KB. Using race technique and library screening the entire cDNA was cloned. This gene was evaluated by sequencing the coding region and splice functions in normal and affected family members with familial atrial fibrillation. Furthermore, haploid cell lines from affected patients were generated and analyzed for deletions that may have been missed by PCR.
        
        
          Results
          We identified two distinct alternately spliced transcripts of this gene. The genomic sequence of the DLG5 gene spanned 79 KB with 32 exons and was shown to have ubiquitous human tissue expression including placenta, heart, skeletal muscle, liver and pancreas.
        
        
          Conclusions
          The entire cDNA of DLG5 was identified, sequenced and its genomic organization determined.

Tags: atrial-fibrillation, chromosome-10q22, dlg5-gene, gene-expression, nih
Organization: U.S. Department of Health & Human Services
Minneapolis-St. Paul-Bloomington, MN-WI

This report presents combined 2005 to 2010 National Survey on Drug Use and Health (NSDUH) results for those aged 12 or older in the Minneapolis-St. Paul-Bloomington, MN-WI metro area. The report includes estimates of substance use disorder, major depressive episode, illicit drug use, marijuana use, cigarette use, binge alcohol use, and the nonmedical use of prescription-type pain relievers. Results are provided for the Minneapolis-St. Paul-Bloomington metro area, Minnesota, and the U.S. overall.

Tags: major-depressive-episode, nsduh-data, samhsa, substance-use-disorder, survey
Organization: U.S. Department of Health & Human Services
Compound 527343: 14,18,22,26-Tetramethyl-hentriacontyl cyanide

Chemical compound data from PubChem database. IUPAC Name: 15,19,23,27-tetramethyldotriacontanenitrile. Molecular Formula: C36H71N. Molecular Weight: 518.0. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Acute respiratory distress syndrome: estimated incidence and mortality rate in a 5 million-person population base

Background:
          Various estimates of the incidence and mortality rate of the acute (adult) respiratory distress syndrome (ARDS) have been published. The studies that led to those estimates were based on relatively small patient populations and employed variable diagnostic identifiers of ARDS. The purpose of this study was to estimate the incidence of ARDS and its mortality rate from a large database to which refined diagnostic criteria were applied. We conducted a retrospective review of all hospital discharges over a 4-year period, using screening criteria designed to select patients with ARDS. Discharges from all acute care hospitals in the state of Maryland were reviewed using a computer database from the Health Services Cost Review Commission (HSCRC). Patients ≥ 12 years of age were included. Screening criteria consisted of ICD-9 codes 518.5 and 518.82 cross-referenced with procedural codes for ventilatory support (96.70, 96.71 and 96.72). Data were normalized to the number of cases per 100,000 people.
        
        
          Results:
          During the 4-year study period there were 2,501,147 hospitalizations. Applying the ICD-9 ARDS criteria yielded lower and upper limits of 159-205, 439-568, 531-694 and 529-720 cases of ARDS for 1992, 1993, 1994 and 1995, respectively. Normalizing for a population of 5 million yields yearly lower and upper limit rates of 3.2-4.2, 8.8-11.4, 10.6-13.8 and 10.5-14.2 cases of ARDS per 100,000 people. Mortality upper and lower limit rates based upon the same duration, admissions and population were 38-49%, 39-52%, 36-47%, and 36-49%, respectively.
        
        
          Conclusions:
          The incidence of ARDS in Maryland is in the range of 10-14 cases per 100,000 people. The ARDS mortality rate is 36% to 52%, similar to that calculated in previous studies.

Tags: ards-incidence, ards-mortality, nih, respiratory-failure, ventilator-use
Organization: U.S. Department of Health & Human Services
Compound 527336: 2-(2-Methylphenyl)-adamantane

Chemical compound data from PubChem database. IUPAC Name: 2-(2-methylphenyl)adamantane. Molecular Formula: C17H22. Molecular Weight: 226.36. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 525060: Silane, [[(16beta,17beta)-estra-1,3,5(10)-triene-3,16,17-triyl]tris(oxy)]tris[trimethyl-

Chemical compound data from PubChem database. IUPAC Name: trimethyl-[[13-methyl-3,16-bis(trimethylsilyloxy)-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl]oxy]silane. Molecular Formula: C27H48O3Si3. Molecular Weight: 504.9. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2010 State Profile — Michigan

This state profile includes data from facilities in Michigan that reported to N-SSATS for the survey reference date March 31, 2010. Data were collected on the location, characteristics, services offered, and number of clients in treatment at alcohol and drug abuse treatment facilities (both public and private) in Michigan. In Michigan, 475 substance abuse treatment facilities were included in the 2010 N-SSATS, reporting that there were 42,174 clients in substance abuse treatment on March 31, 2010. The survey response rate in Michigan was 89.7%.

Tags: alcohol-abuse-treatment, michigan, n-ssats, samhsa, substance-abuse-treatment
Organization: U.S. Department of Health & Human Services
National Estimates of Drug-Related Emergency Department Visits, 2004-2011 - Underage Drinking

Excel file with national estimates, rates, relative standard errors, trends and confidence intervals for all drug-related emergency department (ED) visits involving underage drinking, covering 2004-2011.  Underage drinking includes ED visits that involve alcohol use (alone or with other drugs) for patients under the age of 21.

Tags: alcohol-use, drug-related-visits, ed-visits, samhsa, underage-drinking
Organization: U.S. Department of Health & Human Services
Table 24. Any Mental Illness in the Past Year, by Age Group and State: Percentages, Annual Averages Based on 2013 and 2014 NSDUHs

Table 24. Any Mental Illness in the Past Year, by Age Group and State: Percentages, Annual Averages Based on 2013 and 2014 NSDUHs

Tags: age-group-mental-health, ami-past-year, mental-illness-prevalence, samhsa, state-mental-health
Organization: U.S. Department of Health & Human Services
Uniform Facility Data Set (UFDS): 1997 Data on Substance Abuse Treatment Facilities

This report presents results from the 1997 Uniform Facility Data Set (UFDS), an annual survey of facilities providing substance abuse treatment. Conducted by the Substance Abuse and Mental Health Services Administration (SAMHSA), the UFDS is designed to collect data on the location, characteristics, and use of alcoholism and drug abuse treatment facilities and services throughout the 50 states, the District of Columbia, and other U.S. jurisdictions.

Tags: alcoholism-treatment, drug-abuse-treatment, samhsa, substance-abuse-treatment, treatment-facility-survey
Organization: U.S. Department of Health & Human Services
From immunoglobulin gene fingerprinting to motif-specific hybridization: advances in the analysis of B lymphoid clonality in rheumatic diseases

In rheumatic diseases, autoantibody-producing cells of interest are often hidden in a polyclonal B-lymphocyte population. Immunoglobulin gene fingerprinting is a useful approach to screen for expanding clones and to detect recirculation between different locations. The gene fingerprinting approach and the Southern blot technique have been amalgamated, using electrophoretic transfer of a PCR product from an acrylamide gel onto a nylon membrane followed by hybridization with specific oligonucleotide probes. In contrast to conventional fingerprinting, the authenticity of immunoglobulin genes can be confirmed, individual genes can be detected and handling radionucleotides can be avoided. Also, the membrane may be reused for further investigations.

Tags: autoantibody-producing-cells, b-lymphocyte-clonality, immunoglobulin-genes, nih, rheumatic-diseases
Organization: U.S. Department of Health & Human Services
DAWN 2011 Emergency Department Excel Files

Data tables consisting of Excel files with estimates, rates, relative standard errors, trends and confidence intervals, covering 2004-2011 for drug-related emergency department visits for the Nation and 11 metropolitan areas/divisions. Tables are provided for 10 topics (\"analytic categories\") which are defined in the \"Guide to Drug Abuse Warning Trend Tabls,\"  a separate document.   Each table includes data for over 500 drugs, including illicit drugs, prescription and over-the-counter medications, dietary supplements, inhalants and alcohol. Includes total visits, gender, age group, race/ethnicity, outcome of visit, drug combinations, number of drugs involved in visit, drug frequency, and drugs confirmed by toxicology. Additional detail is provided for illicit drugs, psychotherapeutic drugs, central nervous system (CNS) drugs, respiratory drugs and cardiovascular drugs.

Tags: drug-abuse-trends, drug-related-ed-visits, emergency-department-data, samhsa, toxicology-confirmed-drugs
Organization: U.S. Department of Health & Human Services
Compound 528543: Hexadecane, 8-heptyl

Chemical compound data from PubChem database. IUPAC Name: 8-heptylhexadecane. Molecular Formula: C23H48. Molecular Weight: 324.6. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2022 Uniform Reporting System (URS) Table For Colorado

This is the 2022 Uniform Reporting System (URS) Output Tables for Colorado. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: colorado-health, mental-health-services, national-outcome-measures, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
Minnesota: 2011-2012 NSDUH

This report presents Minnesota\'s estimates for 25 measures of substance use and mental health based on the combined 2011 and 2012 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided by State and for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: major-depressive-episode, mental-health, samhsa, serious-mental-illness, substance-use
Organization: U.S. Department of Health & Human Services
Results from the 2012 National Survey on Drug Use and Health: Summary of National Findings and Detailed Tables

This page presents the annual national findings report and detailed tables from the 2012 National Survey on Drug Use and Health (NSDUH). The annual national findings report and the detailed tables include national estimates of rates of initiation and use of illicit drugs (e.g., marijuana, cocaine, heroin, hallucinogens, inhalants, and the nonmedical use of prescription-type pain relievers, tranquilizers, stimulants, and sedatives), alcohol, and tobacco products and rates of driving under the influence of drugs or alcohol. The the annual national findings report and detailed tables also covers substance use treatment need/receipt and youth risk and prevention measures. Results are provided for age group, gender, pregnancy status, race/ethnicity, education level, employment status, geographic area, parole/probation status. Comparisons are made between 2012 and 2002 to 2011.

Tags: behavioral-health, mental-health, national-survey, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Indiana: 2011-2012 NSDUH

This report presents Indiana\'s estimates for 25 measures of substance use and mental health based on the combined 2011 and 2012 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided by State and for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: illicit-drugs, major-depressive-episode, mental-health, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Ninth Asia Pacific League Of Associations For Rheumatology (APLAR) Congress, Beijing, China, 21-26 May, 2000

The Congress covered the broad field of rheumatology, with participants from China, the Asia Pacific League of Associations for Rheumatology (APLAR) region and the rest of the world. The programme consisted of a mix of plenary lectures, concurrent symposia, workshops, free paper sessions and poster presentations. Basic sciences were well represented, with the general theme of inflammatory cytokines being of particular interest. One plenary lecture and a number of other presentations addressed the problem of atherosclerosis and rheumatic diseases. Diseases prominent in the region, such as Behcet's disease and Takayasu's disease, were represented with large series. Other areas of interest were musculoskeletal infections in HIV-positive patients and the management of spondyloarthritis. Although the use of the most recently developed drugs is restricted in the APLAR region because of cost factors, there were symposia on the latest pharmacological advances such as COX-2 technology, leflunomide and anti-tumour necrosis factor (TNF) therapy.

Tags: asia-pacific-health, behcets-disease, inflammatory-cytokines, nih, rheumatologic-diseases
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Region 3, Volume 7

Explore state and regional data for HHS Region 3 with this user-friendly behavioral health report. It uses data from the 2021-2022 National Surveys on Drug Use and Health (NSDUH). The topics addressed in this report include substance use, substance use disorders, and mental health. Selected estimates are provided for adolescents aged 12 to 17, underage people aged 12 to 20, adults aged 18 or older, and the general population aged 12 or older. Statistical tests compare population percentages of (1) HHS region versus national estimates, (2) state versus national estimates, and (3) state versus HHS region estimates.

Tags: behavioral-health, mental-health, nsduh-data, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
2010 State Profile — Massachusetts

This state profile includes data from facilities in Massachusetts that reported to N-SSATS for the survey reference date March 31, 2010. Data were collected on the location, characteristics, services offered, and number of clients in treatment at alcohol and drug abuse treatment facilities (both public and private) in Massachusetts. In Massachusetts, 307 substance abuse treatment facilities were included in the 2010 N-SSATS, reporting that there were 39,444 clients in substance abuse treatment on March 31, 2010. The survey response rate in Massachusetts was 90.5%.

Tags: addiction-services, massachusetts, n-ssats, samhsa, substance-abuse-treatment
Organization: U.S. Department of Health & Human Services
Small-scale analysis of exopolysaccharides from

Background
          Exopolysaccharides (EPSs) produced by lactic acid bacteria are important for the texture of fermented foods and have received a great deal of interest recently. However, the low production levels of EPSs in combination with the complex media used for growth of the bacteria have caused problems in the accurate analysis of the EPS. The purpose of this study was to find a growth medium for physiological studies of the lactic acid bacterium Streptococcus thermophilus, and to develop a simple method for qualitative and quantitative analysis of EPSs produced in this medium.
        
        
          Results
          A semi-defined polysaccharide medium was developed and evaluated on six strains of Streptococcus thermophilus. The EPSs were analysed using a novel protocol incorporating ultracentrifugation for the removal of interfering sugars, hydrolysis and analysis of the monomer composition by High Performance Anion-Exchange Chromatography with pulsed amperometric detection. The medium and analysis method allowed accurate quantification and monomer analysis of 0.5 ml samples of EPSs from tube cultures.
        
        
          Conclusions
          The presented medium should be useful for physiological studies of S. thermophilus, and, in combination with the method of analysis of EPS, will allow downscaling of physiological studies and screening for EPSs.

Tags: exopolysaccharides, lactic-acid-bacteria, nih, polysaccharide-medium, streptococcus-thermophilus
Organization: U.S. Department of Health & Human Services
Wyoming: 2011-2012 NSDUH

This report presents Wyoming\'s estimates for 25 measures of substance use and mental health based on the combined 2011 and 2012 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided by State and for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: mental-health, nsduh, samhsa, substance-use, wyoming
Organization: U.S. Department of Health & Human Services
Analysis of State Child Welfare Data: VCIS Survey Data From 1990 Through 1994

This report presents an analysis of state child welfare data on child substitute care and adoption that was gathered through the Voluntary Cooperative Information System (VCIS) for the years 1990 to 1994.

The PDF is best viewed in Chrome or Firefox. If using Internet Explorer (IE), please right click the link, save the file, and view it locally.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: adoption, child, data, policy, reporting
Organization: U.S. Department of Health & Human Services