AndreaBozzo/ceres-open-data-index huggingface dataset:
Agonizing Hedgehog

It is a rare treat when a drug discovery program teaches us something about the biology of the process that it attempts to modulate. The paper by Maria Frank-Kamenetsky and colleagues in this issue of theJournal of Biology[1] presents a compelling example of how the search for therapeutics can provide powerful experimental tools and insights into fundamental biology, blurring the distinction between applied and basic research. By characterizing a small group of chemically similar agonists of theHedgehogsignaling pathway, Frank-Kamenetskyet al. have been able to propose a new model for how theSmoothenedcomponent of the Hedgehog-receptor complex works, and to hint at the existence of natural-ligand agonists of the Hedgehog signaling pathway (see'The bottom line'box for a summary of their work).

Tags: agonist-identification, chemical-genetics, degenerative-diseases, hedgehog-signaling, nih
Organization: U.S. Department of Health & Human Services
Program Instruction (PI-09-10)

The purpose of this Program Instruction (PI) provides State and Tribal Title IV-E agencies (hereafter, “Title IV-E agencies”) with information regarding changes to the Title IV-E adoption assistance eligibility requirements made by P.L. 110-351.

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Tags: adoption, data, guidance, instruction, policy
Organization: U.S. Department of Health & Human Services
Program Instruction (PI-05-04)

This Program Instruction (PI) provides instruction to states on the June 30, 2005 submission of the Annual Progress and Services Report (APSR) required under Title IV-B of the Social Security Act (the Act), the Child Abuse Prevention and Treatment Act (CAPTA), and the Chafee Foster Care Independence Program (CFCIP), including the Education and Training Vouchers (ETV) program; and the CFS-101, Parts I and II, Annual Budget Request and Annual Summary of Child and Family Services.

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Tags: abuse, foster, instruction, prevention, reporting
Organization: U.S. Department of Health & Human Services
Program Instruction (PI-19-01)

This Program Instruction (PI) provides guidance to state, territorial and tribal title IV-E agencies on the actions required to apply for title IV-B, subpart 2 funding to support the development, enhancement or evaluation of kinship navigator programs. These are federal fiscal year (FY) 2019 funds, provided as part of P.L.115-245, the Department of Defense and Labor, Health and Human Services, and Education Appropriations Act of 2019, enacted September 28, 2018.

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Tags: fiscal, guidance, instruction, kinship, policy
Organization: U.S. Department of Health & Human Services
Arthritis Research: more than a journal		  (http://arthritis-research.com)

We are delighted to welcome you to the first printed issue ofArthritis Research, a publication that has already existed on the		  Internet for the last few months. This fact alone is an indication that we are		  beginning a new type of publication - one that will have the goal of serving		  the multidisciplinary research community looking at all aspects of arthritis		  and related autoimmune diseases.

Tags: arthritis-research, joint-inflammation, nih, osteoarthritis, rheumatology
Organization: U.S. Department of Health & Human Services
Program Instruction (PI-00-03)

This Program Instruction (PI) summarizes the actions required by States to submit the Annual Progress and Services Report required for Title IV-B of the Social Security Act (the Act) and the CFS-101, Annual Budget Request and Annual Summary of Child and Family Services.

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Tags: child, instruction, policy, reporting, scope
Organization: U.S. Department of Health & Human Services
Program Instruction (PI-98-07)

This Program Instruction (PI) provides information on the procedures for Establishing Adoption and Guardianship Baselines to Implement the Presidential Initiative, Adoption 2002 and the Requirements of the Adoption and Safe Families Act of 1997.

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Tags: adoption, guardianship, instruction, policy, regulation
Organization: U.S. Department of Health & Human Services
Information Memorandum (IM-00-03)

This Information Memorandum (IM) provides information on public law (P.L.) 106-169, the Foster Care Independence Act of 1999, title I, subtitles A-D; Information on preliminary program implementation and availability of fiscal year (FY) 2000 funds.

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Tags: child, fiscal, foster, policy, social
Organization: U.S. Department of Health & Human Services
Program Instruction (PI-20-08)

The purpose of this Program Instruction (PI) is to provide guidance to title IV-E agencies that on September 30, 2019 were operating a title IV-E child welfare waiver demonstration project under the authority of section 1130 of the Act on the actions required to be considered for a Funding Certainty Grant.

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Tags: child, grant, guidance, instruction, policy
Organization: U.S. Department of Health & Human Services
Program Instruction (PI-11-06)

This Program Instruction (PI) provides instruction to states on the June 30, 2011 submission of the Annual Progress and Services Report (APSR) required under Title IV-B of the Social Security Act (the Act) for the Stephanie Tubbs Jones Child Welfare Services (CWS) and Promoting Safe and Stable Families (PSSF) Programs, the Child Abuse Prevention and Treatment Act (CAPTA) State Grant Program; and the Chafee Foster Care Independence Program (CFCIP) and the Education and Training Vouchers (ETV) Program; and the CFS-101, Part I, Annual Budget Request, Part II, Annual Summary of Child and Family Services, and Part III, Annual Expenditure Report—Title IV-B, subparts 1 and 2, CFCIP, and ETV.

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Tags: abuse, foster, grant, prevention, reporting
Organization: U.S. Department of Health & Human Services
The role of IFN-gamma in systemic lupus erythematosus: a challenge to the Th1/Th2 paradigm in autoimmunity

Cytokines play a critical role in regulating lymphoid cell responses to most antigenic stimuli, and it is therefore very likely that these molecules profoundly affect the pathogenesis of autoimmune diseases. Consequently, investigations of the role of cytokines as effectors or predisposing elements in these diseases have received prominent attention for many years. Early findings from such studies, however, were frequently contradictory and, more importantly, difficult to incorporate into a conceptual framework. A new impetus in this area was provided by the discovery of Mosmann and colleagues that T cells could be conveniently divided into two main subsets, ie Th1 and Th2, with distinct arrays of cytokine secretion patterns and functions [1,2]. A hypothesis was subsequently formulated according to which cell-mediated autoimmune diseases, such as insulin-dependent diabetes mellitus, are induced by Th1 cells and their cytokines, and humorally-mediated autoimmune diseases, such as systemic lupus erythematosus, are induced by Th2 cells and their cytokines. As reviewed below, findings on the primary role of IFN-γ in the pathogenesis of murine lupus and other observations clearly refute this hypothesis.

Tags: ifn-gamma, interferon-gamma, nih, systemic-lupus-erythematosus, th1-th2-paradigm
Organization: U.S. Department of Health & Human Services
Arthritis Research: the move to publish research articles in full online only

WhenArthritis Researchwas launched in 1999 the publishers and ourselves took the innovative decision to make all primary research articles available to everyone for free through the journal's own websitehttp://arthritis-research.comas well as through PubMed Centralhttp://www.pubmedcentral.nih.gov/, the National Institute of Health's repository for biomedical research articles, and through the BioMed Central (BMC) websitehttp://biomedcentral.com. We now feel that it is time to lead the way forward again by only publishing research articles in full online beginning with volume 4 number 4 ofArthritis Research.

Tags: arthritis-research, joint-inflammation, nih, rheumatoid-arthritis, rheumatology
Organization: U.S. Department of Health & Human Services
Multipletelophase arrest bypassed (tab)mutants alleviate the essential requirement for Cdc15 in exit from mitosis inS. cerevisiae

The Mitotic Exit Network (MEN) proteins – including the protein kinase Cdc15 and the protein phosphatase Cdc14 – are essential for exit from mitosis inSaccharomyces cerevisiae.To identify downstream targets of the MEN, we soughttelophase arrest bypassed (tab)mutations that bypassed the essential requirement forCDC15.Previous studies identifiednet1tab2-1andCDC14TAB6-1as mutations in the RENT complex subunits Net1 and Cdc14, respectively, and revealed that the MEN acts by promoting release of Cdc14 from its nucleolar Net1 anchor during anaphase. However, the remainingtabmutants were not characterized.

Tags: cdc14-phosphatase, mitotic-exit-network, nih, saccharomyces-cerevisiae, telophase-arrest
Organization: U.S. Department of Health & Human Services
Critical Carenon-peer-review research depository

The tradition of circulating research findings before peerreview is		  old and continues today. In addition to the informal circulation of		  non-peer-reviewed research reports between scientists, there are also		  well-organised schemes, of which the most established currently is the		  Internet-based preprint repository in physics run from the Los Alamos Institute		  (http://arxiv.org/). The National Institutes of Health (NIH) also offered a		  successful and well regarded preprint service in the 1960s.

Tags: critical-care, intensive-care, medical-research, nih, patient-outcomes
Organization: U.S. Department of Health & Human Services
Action Transmittal (AT-81-01)

This Action Transmittal (AT) provides information on:

(1) New Approved Annual budget Request Form for Child Welfare Services, Title IV-B (CWS-101)
(2) Tentative Allotment for Submittal of CWS-101 for FY 81 Funds for Title IV-B

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Tags: budget, child, fiscal, guidance, policy
Organization: U.S. Department of Health & Human Services
Information Memorandum (IM-94-17)

This Information Memorandum (IM) establishes Fiscal Year (FY) 1994 Allotments for Title IV-B and Procedures for Applying for: (1) Funds available to a State or Indian Tribal Organization (ITO) from its FY l994 allotment and (2) for States only, Realloted IV-B Funds.

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Tags: child, fiscal, guidance, policy, scope
Organization: U.S. Department of Health & Human Services
Information Memorandum (IM-16-05)

The purpose of this Information Memorandum (IM) is to inform states of the enactment of CARA and provide basic information on the resulting changes in CAPTA for child abuse or neglect prevention and treatment programs.

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Tags: abuse, guidance, neglect, policy, prevention
Organization: U.S. Department of Health & Human Services
Information Memorandum (IM-13-01)

This Information Memorandum (IM) supersedes ACYF-CB-IM-05-02 issued May 3, 2005. This IM provides information to title IV-E agencies seeking an exemption from prior Federal approval related to automated data processing equipment and services procurements.

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Tags: child, federal, policy, service, social
Organization: U.S. Department of Health & Human Services
Program Instruction (PI-02-04)

This Program Instruction (PI) provides instruction on the availability of Fiscal Year 2002 Funds under the Community-Based Family Resource and Support Grants program created by Title II of the Child Abuse Prevention and Treatment Act Amendments of 1996 (Pub.L.104-235).

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Tags: abuse, fiscal, grant, instruction, prevention
Organization: U.S. Department of Health & Human Services
Information Memorandum (IM-16-06)

This Information Memorandum (IM) provides an overview of the CCWIS rule to IT staff of the title IV-E agencies. This IM includes the CCWIS Overview for State and Tribal IT Staff attachment.

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Tags: child, policy, scope, staff, state
Organization: U.S. Department of Health & Human Services
Thefrizzledpathway regulates the development of arista laterals.

Thefrizzledpathway in Drosophila has been studied intensively for its role in the development of planar polarity in wing hairs, thoracic bristles and ommatidia. Selected cells in the arista (the terminal segment of the antenna) elaborate a lateral projection that shares characteristics with both hairs and bristles.

Tags: arista-development, drosophila-melanogaster, frizzled-pathway, nih, planar-polarity
Organization: U.S. Department of Health & Human Services
Program Instruction (PI-20-11)

This Program Instruction (PI) provides guidance to agencies administering title IV-B, subpart 1 of the Act (the Stephanie Tubbs Jones Child Welfare Services Program) on the supplemental fiscal year (FY) 2020 funding provided under the CARES Act.The PI provides information on the allowable use of the funding and actions states, territories and tribes must take to report on planned and actual use of the funds.

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Tags: fiscal, guidance, instruction, mental, policy
Organization: U.S. Department of Health & Human Services
Program Instruction (PI-10-08)

This Program Instruction (PI) provides instruction to Tribes on the June 30, 2010 Submission of the Annual Progress and Services Report (APSR) required under Title IV-B of the Social Security Act (the Act) for the Stephanie Tubbs Jones Child Welfare Services and Promoting Safe and Stable Families (PSSF) Programs, and the Chafee Foster Care Independence Program (CFCIP), including the Education and Training Vouchers (ETV) program; submission of the CFS-101, Part I, Annual Budget Request; Part II, Annual Summary of Child and Family Services; and Part III, Annual Expenditures for Title IV-B, Subparts 1 and 2.

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Tags: foster, guidance, instruction, policy, reporting
Organization: U.S. Department of Health & Human Services
Program Instruction (PI-14-03)

This Program Instruction (PI) provides instruction to States on the June 30, 2014, submission of: (1) the Child and Family Services Plan (CFSP) Final Report for fiscal years (FYs) 2010-2014 (the “2010-2014 Final Report”) and CAPTA update; (2) the CFSP for FYs 2015-2019 (the “2015-2019 CFSP”) for the Stephanie Tubbs Jones Child Welfare Services (CWS), the Promoting Safe and Stable Families (PSSF) and Monthly Caseworker Visit Grant programs; and the Chafee Foster Care Independence Program (CFCIP) and the Education and Training Vouchers (ETV) Program; and (3) the CFS-101, Part I, Annual Budget Request, Part II, Annual Summary of Child and Family Services, and Part III, Annual Expenditure Report- Title IV-B, subparts 1 and 2, CFCIP, and ETV.

PI-14-03 (PDF)

Fiscal Year 2014 Allotment Title IV-B Subpart 1 Stephanie Tubbs Jones Child Welfare Services
Fiscal Year 2014 Allotment Title IV-B Subpart 2 Promoting Safe and Stable Families
Fiscal Year 2014 Allotment for Title IV-B, Subpart 2 Monthly Caseworker Visit Funds
Fiscal Year 2014 Allotment for CAPTA
Fiscal Year 2014 Allotment for Chafee Foster Care Independence Program
Fiscal Year 2014 Allotment for Education and Training Vouchers

CFS-101 Part I: Annual Budget Request for Title IV-B, subparts 1 and 2, CAPTA, Chafee
Foster Care Independence (CFCIP) and Education and Training Voucher (ETV) Program Instructions
CFS-101 Part I: Annual Budget Request for Title IV-B, subparts 1 and 2, CAPTA, Chafee Foster Care Independence (CFCIP) and Education and Training Voucher (ETV) Program Form (Excel (XLSX) - 15 KB)
CFS-101, Part II: Annual Summary of Child and Family Services Instructions
CFS-101, Part II: Annual Summary of Child and Family Services Form (Excel (XLSX) - 15 KB)
CFS-101, Part III: Annual Expenditures for Title IV-B, subparts 1 and 2, CAPTA, Chafee Foster Care Independence (CFCIP) and Education and Training Voucher (ETV) Instructions
CFS-101, Part III: Annual Expenditures for Title IV-B, subparts 1 and 2, CAPTA, Chafee Foster Care Independence (CFCIP) and Education and Training Voucher (ETV) Form (Excel (XLSX) - 14 KB)

Assurance and Certifications

CB Regional Program Managers

NCANDS State Contact List

Annual Reporting of Education and Training Vouchers Awarded (Word  (DOCX)- 20 KB)

Current Variances in Title IV-B Provisions of Law and Regulation

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Tags: fiscal, foster, grant, instruction, reporting
Organization: U.S. Department of Health & Human Services
Information Memorandum (IM-87-04)

This Information Memorandum (IM) provides information on P.L. 99-177, the "Balanced Budget and Emergency Deficit Control Act of 1985" ("Gramm-Rudman-Hollings").

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Tags: budget, fiscal, policy, regulation, social
Organization: U.S. Department of Health & Human Services
Information Memorandum (IM-95-05)

This Information Memorandum (IM) provides information on New Legislation: Authorization of Demonstration Projects and Waivers for Programs under Title IV-B or IV-E of the Social Security Act (the Act).

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Tags: child, family, policy, program, social
Organization: U.S. Department of Health & Human Services
Program Instruction (PI-08-03)

This Program Instruction (PI) provides instruction to states on the June 30, 2008 submission of the Annual Progress and Services Report (APSR) required under Title IV-B of the Social Security Act (the Act), the Child Abuse Prevention and Treatment Act (CAPTA), and the Chafee Foster Care Independence Program (CFCIP), including the ETV program; the submission of the CFS-101, Part I, Annual Budget Request, Part II, Annual Summary of Child and Family Services, and Part III, Annual Expenditure Report—Title IV-B, Subparts 1 and 2, CFCIP and ETV.

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Tags: abuse, compliance, foster, prevention, reporting
Organization: U.S. Department of Health & Human Services
Information Memorandum (IM-07-06)

This Information Memorandum (IM) provides instruction on the Appropriate Referrals, Requests for Location Services, Child Support Applications, and Electronic Interface between Child Welfare and Child Support Enforcement Agencies. Effective August 1, 2012, the guidance in this IM has been superseded by ACYF-CB-IM-12-06.

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Tags: child, guidance, policy, scope, support
Organization: U.S. Department of Health & Human Services
Information Memorandum (IM-17-05)

This Information Memorandum (IM) informs title IV-E agencies that for adoption assistance agreements entered into on or after October 1, 2017, eligibility for title IV-E adoption assistance must be determined using the “applicable child” eligibility criteria described in section 473(a)(2)(C)(ii) of the Social Security Act.

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Tags: adoption, child, grant, guidance, policy
Organization: U.S. Department of Health & Human Services
Information Memorandum (IM-88-12)

This Information Memorandum (IM) provides information on the amendments to Section 102 of P.L. 96-272 and Title IV-E of the Social Security Act (the Act) Resulting from the 1987 Omnibus Budget Reconciliation Act (P.L. 100-203).

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Tags: budget, child, fiscal, policy, scope
Organization: U.S. Department of Health & Human Services
Program Instruction (PI-12-01)

This Program Instruction (PI) provides guidance on data requirements for States related to reporting monthly caseworker visits under Title IV-B of the Social Security Act (the Act) as revised by the Child and Family Services Improvement and Innovation Act [Public Law (P.L. 112-34)], enacted September 30, 2011.

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Tags: assessment, compliance, instruction, policy, reporting
Organization: U.S. Department of Health & Human Services
Information Memorandum (IM-15-01)

This Information Memorandum (IM) informs state and tribal title IV-E agencies about the publication of the Adoption and Foster Care Analysis and Reporting System (AFCARS) Notice of Proposed Rule Making (NPRM) and where to submit comments.

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Tags: adoption, compliance, foster, policy, reporting
Organization: U.S. Department of Health & Human Services
Program Instruction (PI-03-05)

This Program Instruction (PI) provides instruction on the June 30, 2003 submission of the Annual Progress and Services Report required under title IV-B of the Social Security Act (the Act), the Child Abuse Prevention and Treatment Act (CAPTA), and the Chafee Foster Care Independence Program (CFCIP); and the CFS-101, Annual Budget Request and Annual Summary of Child and Family Services.

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Tags: abuse, compliance, foster, prevention, reporting
Organization: U.S. Department of Health & Human Services
Program Instruction (PI-17-04)

This Program Instruction (PI) provides guidance to Indian tribes, tribal organizations, and tribal consortia (tribes) on actions they are required to take in order to receive their allotments for Fiscal Year (FY) 2018 (subject to the availability of appropriations) authorized under title IV-B, subparts 1 and/or 2, the CFCIP, and the ETV program. Please note that tribes with either an approved title IV-E plan or a title IV-E tribal/state cooperative agreement or contract have the option to apply to receive FY 2018 CFCIP and/or ETV funds directly from the Secretary. (See Section D of this PI.)

PI-17-04 (PDF)

Tribes should use FY 2016 allocation tables as the basis for estimating FY 2018 budget requests.

Fiscal Year 2016 Allotments for Title IV-B, Subpart 1 - Stephanie Tubbs Jones Child Welfare Services
Fiscal Year 2016 Allotments for Title IV-B, Subpart 2 - Promoting Safe and Stable Families
Fiscal Year 2016 Allotments for Chafee Foster Care Independence Program
Fiscal Year 2016 Allotment for Education and Training Voucher Program

CFS-101 Instructions

Introduction
Part I: Annual Budget Request for Title IV-B, Subpart 1 & 2 Funds, CAPTA, CFCIP, and ETV Instructions
Part II: Annual Estimated Expenditure Summary of Child and Family Services Instructions
Part III: Expenditures for Title IV-B, Subparts 1 and 2, Chafee Foster Care Independence (CFCIP) and Education and Training Voucher (ETV) Programs Instructions

CFS-101 Forms, Parts I, II and III Excel Workbook (XLSX) (36 KB)

CFS-101 Forms Part I
CFS-101 Forms Part II
CFS-101 Forms Part III

Certification of Tribal Population Under Age 21 (PDF  (PDF)- 542 KB)

Children’s Bureau Regional Program Managers

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Tags: child, fiscal, guidance, instruction, policy
Organization: U.S. Department of Health & Human Services