AndreaBozzo/ceres-open-data-index huggingface dataset:
Colorado (CO)

This report presents Colorado\'s estimates for 25 measures of substance use and mental health based on the combined 2009 and 2010 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for Colorado for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: colorado-health, mental-health, nsduh-data, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Table 20. Dependence or Abuse of Illicit Drugs or Alcohol in the Past Year, by Age Group and State: Percentages, Annual Averages Based on 2010 and 2011 NSDUHs

This report presents State estimates for measures of past year illicit drug or alcohol dependence or abuse based on the combined 2010 and 2011 National Surveys on Drug Use and Health (NSDUHs). Resuts are provided by age group.

Tags: alcohol-dependence, drug-abuse, nsduh-data, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
Identification of genes involved in ceramide-dependent neuronal apoptosis using cDNA arrays

A cell-culture model was used to establish a profile of gene expression during the effector phase of ceramide-mediated cell death. Of the 239 genes that met the criteria for differential hybridization, 10 correspond to genes previously involved in C2-ceramide or TNF-α signaling pathways and 20 in neuronal disorders, oncogenesis or more broadly in the regulation of proliferation.

Tags: cell-death, ceramide-signaling, gene-expression, neuronal-apoptosis, nih
Organization: U.S. Department of Health & Human Services
2018 Uniform Reporting System (URS) Table for Arkansas

This is the 2018 Uniform Reporting System (URS) Output Tables for Arkansas. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-data, mental-health-services, national-outcome-measures, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
2012 Uniform Reporting System (URS) Tables for Virginia

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2012. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-program, community-mental-health, mental-health-services, outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Beta-Adrenergic gene therapy for cardiovascular disease

Gene therapy using in vivo recombinant adenovirus-mediated gene transfer is an effective technique that offers great potential to improve existing drug treatments for the complex cardiovascular diseases of heart failure and vascular smooth muscle intimal hyperplasia. Cardiac-specific adenovirus-mediated transfer of the carboxyl-terminus of the β-adrenergic receptor kinase (βARKct), acting as a Gβγ-β-adrenergic receptor kinase (βARK)1 inhibitor, improves basal and agonist-induced cardiac performance in both normal and failing rabbit hearts. In addition, βARKct adenovirus infection of vascular smooth muscle is capable of significantly diminishing neointimal proliferation after angioplasty. Therefore, further investigation is warranted to determine whether inhibition of βARK1 activity and sequestration of Gβγ via an adenovirus that encodes the βARKct transgene might be a useful clinical tool for the treatment of cardiovascular pathologies.

Tags: adrenergic-receptors, gene-therapy, heart-failure, intimal-hyperplasia, nih
Organization: U.S. Department of Health & Human Services
Workplace Policies and Programs Concerning Alcohol and Drug Use

This short report uses 2008 to 2012 National Survey on Drug Use and Health (NSDUH) to assess receipt of workplace policies and programs regarding substance use among full-time employed workers aged 18 to 64 by past month illicit drug use or heavy alcohol use status.

Tags: employee-assistance-programs, nsduh-data, samhsa, substance-use-disorders, workplace-drug-testing
Organization: U.S. Department of Health & Human Services
2019 Uniform Reporting System (URS) Table for Indiana

These are the 2019 Uniform Reporting System (URS) Output Tables for Indiana. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: mental-health-services, national-outcome-measures, samhsa, substance-abuse, urs-data
Organization: U.S. Department of Health & Human Services
Transcriptional transactivation by selected short random peptides attached to lexA-GFP fusion proteins

Background
          Transcriptional transactivation is a process with remarkable tolerance for sequence diversity and structural geometry. In studies of the features that constitute transactivating functions, acidity has remained one of the most common characteristics observed among native activation domains and activator peptides.
        
        
          Results
          We performed a deliberate search of random peptide libraries for peptides capable of conferring transcriptional transactivation on the lexA DNA binding domain. Two libraries, one composed of C-terminal fusions, the other of peptide insertions within the green fluorescent protein structure, were used. We show that (i) peptide sequences other than C-terminal fusions can confer transactivation; (ii) though acidic activator peptides are more common, charge neutral and basic peptides can function as activators; and (iii) peptides as short as 11 amino acids behave in a modular fashion.
        
        
          Conclusions
          These results support the recruitment model of transcriptional activation and, combined with other studies, suggest the possibility of using activator peptides in a variety of applications, including drug development work.

Tags: gene-expression, lexa-gfp-fusion, nih, peptide-libraries, transcriptional-transactivation
Organization: U.S. Department of Health & Human Services
2015 CMHS Uniform Reporting System (URS) Table for Indiana

2015 Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for Indiana. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, national-outcome-measures, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
4.21b Type of care offered in facilities with Opioid Treatment Programs (OTPs), by facility operation and primary focus of facility: 2011. Percent

This is a National Survey of Substance Abuse Treatment Services (N-SSATS) data table showing the type of care offered in facilities with Opioid Treatment Programs (OTPs), by facility operation and primary focus of facility in 2011. N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 States, the District of Columbia, and other U.S. jurisdictions.

Tags: facility-characteristics, opioid-treatment, samhsa, substance-abuse, treatment-services
Organization: U.S. Department of Health & Human Services
Youth Mental Health Tables (Prevalence Estimates) - 2.1 to 2.14

These detailed tables present totals and prevalence estimates of mental health related issues among adolescents aged 12 to 17 from the 2012 National Survey on Drug Use and Health (NSDUH). Tables with data on ayouths include measures on mental health service utilization, MDE, treatment for depression (among youths with MDE), and co-occurrence of mental disorders with substance use or with substance use disorders. Results are provided by age group, gender, race/ethnicity, education level, county type, poverty level, insurance status, overal health, and geographic area. Comparisons are made between 2012 and 2011.

Tags: mde-prevalence, mental-health-services, samhsa, substance-use-disorders, youth-mental-health
Organization: U.S. Department of Health & Human Services
Instructions To Update The SAMHSA SMI And SED Estimates URS Table 1: Number Of Adults With Serious Mental Illness, Age 18 And Older, By State, 2018

This is a Uniform Reporting System (URS) series of tables that details the number of adults with serious mental illness (SMI), ages 18 and older, by State, from 2018.

Tags: adult-smi-estimates, mental-health-statistics, samhsa, serious-mental-illness, state-level-data
Organization: U.S. Department of Health & Human Services
2012 State Profile - New Hampshire

This is a National Survey of Substance Abuse Treatment Services (N-SSATS) annual report showing the state profile for New Hampshire in 2012. N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 States, the District of Columbia, and other U.S. jurisdictions.

Tags: alcohol-drug-abuse, new-hampshire, samhsa, substance-abuse-treatment, treatment-facilities
Organization: U.S. Department of Health & Human Services
Table 8. Nonmedical Use of Pain Relievers in the Past Year, by Age Group and State: Percentages, Annual Averages Based on 2013 and 2014 NSDUHs

Table 8. Nonmedical Use of Pain Relievers in the Past Year, by Age Group and State: Percentages, Annual Averages Based on 2013 and 2014 NSDUHs

Tags: nsduh-survey, pain-reliever-misuse, prescription-drug-abuse, samhsa, substance-use-prevalence
Organization: U.S. Department of Health & Human Services
Clinical review: Splanchnic ischaemia

Inadequate splanchnic perfusion is associated with increased morbidity and mortality, particularly if liver dysfunction coexists. Heart failure, increased intra-abdominal pressure, haemodialysis and the presence of obstructive sleep apnoea are among the multiple clinical conditions that are associated with impaired splanchnic perfusion in critically ill patients. Total liver blood flow is believed to be relatively protected when gut blood flow decreases, because hepatic arterial flow increases when portal venous flow decreases (the hepatic arterial buffer response [HABR]). However, there is evidence that the HABR is diminished or even abolished during endotoxaemia and when gut blood flow becomes very low. Unfortunately, no drugs are yet available that increase total hepato-splanchnic blood flow selectively and to a clinically relevant extent. The present review discusses old and new concepts of splanchnic vasoregulation from both experimental and clinical viewpoints. Recently published trials in this field are discussed.

Tags: gut-blood-flow, intestinal-ischemia, liver-perfusion, nih, splanchnic-ischemia
Organization: U.S. Department of Health & Human Services
Quality and methods of developing practice guidelines

Background
          It is not known whether there are differences in the quality and recommendations between evidence-based (EB) and consensus-based (CB) guidelines. We used breast cancer guidelines as a case study to assess for these differences.
        
        
          Methods
          Five different instruments to evaluate the quality of guidelines were identified by a literature search. We also searched MEDLINE and the Internet to locate 8 breast cancer guidelines. These guidelines were classified in three categories: evidence based, consensus based and consensus based with no explicit consideration of evidence (CB-EB). Each guideline was evaluated by three of the authors using each of the instruments. For each guideline we assessed the agreement among 14 decision points which were selected from the NCCN (National Cancer Comprehensive Network) guidelines algorithm. For each decision point we recorded the level of the quality of the information used to support it. A regression analysis was performed to assess if the percentage of high quality evidence used in the guidelines development was related to the overall quality of the guidelines.
        
        
          Results
          Three guidelines were classified as EB, three as CB-EB and two as CB. The EB guidelines scored better than CB, with the CB-EB scoring in the middle among all instruments for guidelines quality assessment. No major disagreement in recommendations was detected among the guidelines regardless of the method used for development, but the EB guidelines had a better agreement with the benchmark guideline for any decision point. When the source of evidence used to support decision were of high quality, we found a higher level of full agreement among the guidelines' recommendations. Up to 94% of variation in the quality score among guidelines could be explained by the quality of evidence used for guidelines development.
        
        
          Conclusion
          EB guidelines have a better quality than CB guidelines and CB-EB guidelines. Explicit use of high quality evidence can lead to a better agreement among recommendations. However, no major disagreement among guidelines was noted regardless of the method for their development.

Tags: breast-cancer-guidelines, consensus-based-guidelines, evidence-based-guidelines, guideline-quality, nih
Organization: U.S. Department of Health & Human Services
2021 Uniform Reporting System (URS) Table For American Samoa

This is the 2021 Uniform Reporting System (URS) Output Tables for American Samoa. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: american-samoa, block-grant-data, mental-health-services, outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Design and intermediate results of the Lower Extremity Arterial Disease Event Reduction (LEADER)* trial of bezafibrate in men with lower extremity arterial disease [ISRCTN41194621]

Background
          Raised levels of both triglycerides and fibrinogen, each of which are reduced by bezafibrate, may contribute to lower extremity arterial disease (LEAD). This condition is characterized by a particularly high incidence of coronary heart disease (CHD) and stroke, but is little studied thus far in randomised controlled trials.
        
        
          Method
          Patients were recruited through 85 practices in the British Medical Research Council General Practice Research Framework and through nine hospital vascular clinics. The treatment regimen, which is double-blind and placebo-controlled, is bezafibrate 400 mg/day. The 1568 patients recruited represent 86% of those eligible at screening.
        
        
          Results
          None of the anticipated side effects (mainly gastrointestinal) differed between the two groups. Nearly 80% of the total person-years accrued at 3 years were spent on trial treatment. Bezafibrate significantly reduced total cholesterol by approximately 8.0% and low-density lipoprotein (LDL)-cholesterol by approximately 9.0%, and increased high-density lipoprotein (HDL)-cholesterol by approximately 11.0% initially, falling to about 6.0% at 3 years. Triglycerides were significantly reduced by about 23.0% and fibrinogen by about 14.0%. Plasma creatinine rose by approximately 11% in those on active treatment. All of these effects were highly significant (P < 0.0001). Bezafibrate had no effect on the level of C-reactive protein (CRP).
        
        
          Conclusion
          The trial recruited an unusually high proportion of eligible patients, ensuring the general applicability of its results. The fibrinogen-lowering and lipid-modifying effects of bezafibrate were confirmed. Although bezafibrate lowers fibrinogen, it has no effect on CRP; this suggests that the reduction in fibrinogen is due to an effect on its metabolism rather than suppression of an inflammatory response.

Tags: bezafibrate-trial, cardiovascular-risk, lipid-management, lower-extremity-arterial-disease, nih
Organization: U.S. Department of Health & Human Services
Safety of a new extensively hydrolysed formula in children with cow's milk protein allergy: a double blind crossover study

Background
          Formulae for infants with cow's milk protein allergy (CMA) should be based on extensively hydrolysed protein. 'Extensively' however is not strictly defined. Differences in molecular weight and peptide chain length may affect its clinical outcome. We studied the safety of a new extensively hydrolysed casein based formula (Frisolac Allergycare®: FAC) for children with IgE mediated CMA.
        
        
          Methods
          Thirty children, aged 1.5 – 14.8 years old (median 4.9 years) with persistent CMA were enrolled in this double-blind reference product (Nutramigen®: NUT) controlled crossover study. All had positive skin prick tests (SPT) and IgE mediated allergy, showing immediate reactions after ingestion of small amounts of milk. Twenty-five children also had positive radio allergen sorbent tests (RAST) to cow's milk. Formulae provided consisted of 80% elementary formula in combination with 20% reference or test product. Crossover periods lasted for two weeks. From both products molecular weight (MALDI-TOF method and HPLC) and peptide chain length distribution (adapted Edman degradation) were determined.
        
        
          Results
          Maximum molecular weights of NUT and FAC are 2.1 and 2.56 kDa, respectively. The contribution of free amino acids and small peptides <0.5 kDa is 46% for FAC and 53% for NUT. About 50% of the protein fraction of both products consists of peptides longer than four amino acids. Three children did not complete the study. The other children all tolerated FAC very well; no adverse reactions were reported.
        
        
          Conclusions
          The new extensively hydrolysed casein-based formula (FAC) can safely be used in children with IgE mediated cow's milk allergy.

Tags: cow-milk-allergy, double-blind-study, hydrolyzed-formula, nih, pediatric-allergy
Organization: U.S. Department of Health & Human Services
Identification of critical residues in loop E in the 5-HT

Background
          The serotonin type 3 receptor (5-HT3R) is a member of a superfamily of ligand gated ion channels. All members of this family share a large degree of sequence homology and presumably significant structural similarity. A large number of studies have explored the structure-function relationships of members of this family, particularly the nicotinic and GABA receptors. This information can be utilized to gain additional insights into specific structural and functional features of other receptors in this family.
        
        
          Results
          Thirteen amino acids in the mouse 5-HT3ASR that correspond to the putative E binding loop of the nicotinic α7 receptor were chosen for mutagenesis. Due to the presence of a highly conserved glycine in this region, it has been suggested that this binding loop is comprised of a hairpin turn and may form a portion of the ligand-binding site in this ion channel family. Mutation of the conserved glycine (G147) to alanine eliminated binding of the 5-HT3R antagonist [3H]granisetron. Three tyrosine residues (Y140, Y142 and Y152) also significantly altered the binding of 5-HT3R ligands. Mutations in neighboring residues had little or no effect on binding of these ligands to the 5-HT3ASR.
        
        
          Conclusion
          Our data supports a role for the putative E-loop region of the 5-HT3R in the binding of 5-HT, mCPBG, d-tc and lerisetron. 5-HT and mCPBG interact with Y142, d-tc with Y140 and lerisetron with both Y142 and Y152. Our data also provides support for the hypothesis that this region of the receptor is present in a loop structure.

Tags: 5-ht3-receptor, ligand-binding, nih, serotonin-receptor, site-directed-mutagenesis
Organization: U.S. Department of Health & Human Services
NSDUH 2018 Data Collection Final Report

This report describes tasks relating to data collection for the 2018 NSDUH: Sampling and Counting and Listing Operations, Data Collection Staffing, Preparation of Survey Materials, Field Staff Training, Data Collection, Data Collection Results, and Quality Control.

Tags: data-collection-methods, nsduh-data, quality-control, samhsa, survey-methodology
Organization: U.S. Department of Health & Human Services
Denver: Drug-Related Emergency Department Visits, 2004-2011 - Seeking Detox

Excel file with estimates, rates, relative standard errors, trends and confidence intervals for all drug-related emergency department (ED) visits involving patients seeking detox in the Denver metropolitan area, covering 2004-2011. This includes nonemergency requests made through the ED for admission to detoxification unit, visits to obtain medical clearance before being incarcerated, and acute emergencies where an individual is experiencing withdrawal symptoms and requests detox. These estimates do not include patients who seek or enter the hospital\'s detox unit through other avenues.

Tags: denver-metro-area, detoxification-seeking, drug-related-ed-visits, samhsa, substance-withdrawal
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Maine, 2014

This is a behavioral health report for the state of Maine. It uses the National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment Services (NSSATS) to address the topics of youth substance use, youth mental health and treatment, adult mental health and treatment, substance use, and substance use treatment for the years 2009 to 2013.

Tags: maine-behavioral-health, mental-health-indicators, samhsa, substance-use-trends, youth-substance-use
Organization: U.S. Department of Health & Human Services