AndreaBozzo/ceres-open-data-index huggingface dataset:
Accumulation of dehydrin-like proteins in the mitochondria of cereals in response to cold, freezing, drought and ABA treatment

Background
          Dehydrins are known as Group II late embryogenesis abundant proteins. Their high hydrophilicity and thermostability suggest that they may be structure stabilizers with detergent and chaperone-like properties. They are localised in the nucleus, cytoplasm, and plasma membrane. We have recently found putative dehydrins in the mitochondria of some cereals in response to cold. It is not known whether dehydrin-like proteins accumulate in plant mitochondria in response to stimuli other than cold stress.
        
        
          Results
          We have found five putative dehydrins in the mitochondria of winter wheat, rye and maize seedlings. Two of these polypeptides had the same molecular masses in all three species (63 and 52 kD) and were thermostable. Drought, freezing, cold, and exogenous ABA treatment led to higher accumulation of dehydrin-like protein (dlp) 63 kD in the rye and wheat mitochondria. Protein 52 kD was induced by cold adaptation and ABA. Some accumulation of these proteins in the maize mitochondria was found after cold exposition only. The other three proteins appeared to be heat-sensitive and were either slightly induced or not induced at all by all treatments used.
        
        
          Conclusions
          We have found that, not only cold, but also drought, freezing and exogenous ABA treatment result in accumulation of the thermostable dehydrins in plant mitochondria. Most cryotolerant species such as wheat and rye accumulate more heat-stable dehydrins than cryosensitive species such as maize. It has been supposed that their function is to stabilize proteins in the membrane or in the matrix. Heat-sensitive putative dehydrins probably are not involved in the stress reaction and adaptation of plants.

Tags: aba-treatment, dehydrin-proteins, mitochondrial-stress, nih, plant-stress-response
Organization: U.S. Department of Health & Human Services
Compound 525495: 5-Methyl-4,6-dithia-1,8-nonadiene

Chemical compound data from PubChem database. IUPAC Name: 3-(1-prop-2-enylsulfanylethylsulfanyl)prop-1-ene. Molecular Formula: C8H14S2. Molecular Weight: 174.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
NSDUH 2024 Pill Images For The NSDUH Questionnaire

This report contains the pill images used in the audio computer-assisted self-interviewing (ACASI) portion of the NSDUH questionnaire. These images are copyrighted and may not be reproduced. The owner of the copyright is SFI Medical Publishing of Lawrence, Kansas.

Tags: medication-images, nsduh-questionnaire, pill-identification, prescription-drugs, samhsa
Organization: U.S. Department of Health & Human Services
Compound 527350: 16,20,24-Trimethyl-hentriacontyl cyanide

Chemical compound data from PubChem database. IUPAC Name: 17,21,25-trimethyldotriacontanenitrile. Molecular Formula: C35H69N. Molecular Weight: 503.9. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 525647: N,N-Dimethyl-N'-phenyl-p-methoxybenzamidine

Chemical compound data from PubChem database. IUPAC Name: 4-methoxy-N,N-dimethyl-N'-phenylbenzenecarboximidamide. Molecular Formula: C16H18N2O. Molecular Weight: 254.33. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2012 State Profile - Alabama

This is a National Survey of Substance Abuse Treatment Services (N-SSATS) annual report showing the state profile for Alabama in 2012. N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 States, the District of Columbia, and other U.S. jurisdictions.

Tags: addiction-services, alabama-health, n-ssats, samhsa, substance-abuse-treatment
Organization: U.S. Department of Health & Human Services
Expression profiles during honeybee caste determination

Background
          Depending on their larval environment, female honeybees develop into either queens or workers. As in other polyphenisms, this developmental switch depends not on genomic differences between queens and workers but on the differential expression of entire suites of genes involved with larval fate. As such, this and other polyphenic systems can provide a novel tool for understanding how genomes and environmental conditions interact to produce different developmental trajectories. Here we use gene-expression profiles during honeybee caste determination to present the first genomic view of polyphenic development.
        
        
          Results
          Larvae raised as queens or workers differed greatly in their gene-expression patterns. Workers remained more faithful than queens to the expression profiles of younger, bipotential, larvae. Queens appeared to both downregulate many of the genes expressed by bipotential larvae and turn on a distinct set of caste-related genes. Queens overexpressed several metabolic enzymes, workers showed increased expression of a member of the cytochrome P450 family, hexameric storage proteins and dihydrodiol dehydrogenase, and young larvae overexpressed two putative heat-shock proteins (70 and 90 kDa), and several proteins related to RNA processing and translation.
        
        
          Conclusions
          Large differences in gene expression between queens and workers indicate that social insect castes have faced strong directional selection pressures. Overexpression of metabolic enzymes by queen-destined larvae appears to reflect the enhanced growth rate of queens during late larval development. Many of the differently expressed genes we identified have been tied to metabolic rates and cellular responses to hormones, a result consistent with known physiological differences between queen and worker larvae.

Tags: gene-expression, honeybee-caste, larval-development, nih, polyphenism
Organization: U.S. Department of Health & Human Services
Dietary fiber showed no preventive effect against colon and rectal cancers in Japanese with low fat intake: an analysis from the results of nutrition surveys from 23 Japanese prefectures

Background
          Since Fuchs' report in 1999, the reported protective effect of dietary fiber from colorectal carcinogenesis has led many researchers to question its real benefit. The aim of this study is to evaluate the association between diet, especially dietary fiber and fat and colorectal cancer in Japan.
        
        
          Methods
          A multiple regression analysis (using the stepwise variable selection method) was performed using the standardized mortality ratios (SMRs) of colon and rectal cancer in 23 Japanese prefectures as objective variables and dietary fiber, nutrients and food groups as explanatory variables.
        
        
          Results
          As for colon cancer, the standardized partial correlation coefficients were positively significant for fat (1,13, P = 0.000), seaweeds (0.41, P = 0.026) and beans (0.45, P = 0.017) and were negatively significant for vitamin A (-0.63, P = 0.003), vitamin C (-0.42, P = 0.019) and yellow-green vegetables (-0.37, P = 0.046). For rectal cancer, the standardized partial correlation coefficient in fat (0.60, P = 0.002) was positively significant. Dietary fiber was not found to have a significant relationship with either colon or rectal cancers.
        
        
          Conclusions
          This study failed to show any protective effect of dietary fiber in subjects with a low fat intake (Japanese) in this analysis, which supports Fuchs' findings in subjects with a high fat intake (US Americans).

Tags: colorectal-cancer, dietary-fiber, mortality-ratios, nih, nutrition-survey
Organization: U.S. Department of Health & Human Services
Impact of rhinitis on airway inflammation: biological and therapeutic implications

There is increasing evidence for a close link between the upper and the lower respiratory tracts and the fact that rhinitis has an important impact on asthma. Several clinical and experimental observations suggest a similar immunopathology between the upper and lower airways in allergic subjects. The common inflammatory process that develops in the respiratory tract explains some of the complex interactions among different clinical diseases such as rhinitis, sinusitis, asthma, bronchial hyperresponsiveness and viral infections. There are also non-inflammatory mechanisms that may contribute to the link between rhinitis and asthma. Moreover, the outcomes of various pharmacological treatments of rhinitis have recently provided further support for the hypothesis of the united airways. We discuss some of the recent observations on the nose-lung interaction and some of the novel therapeutic approaches used to treat rhinitis and asthma that arise from this.

Tags: airway-inflammation, immunopathology, nih, rhinitis-asthma, united-airways
Organization: U.S. Department of Health & Human Services
Compound 525677: 3-Chloro-N-(4-chlorobenzylidene)aniline

Chemical compound data from PubChem database. IUPAC Name: N-(3-chlorophenyl)-1-(4-chlorophenyl)methanimine. Molecular Formula: C13H9Cl2N. Molecular Weight: 250.12. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
South Dakota (SD)

This report presents South Dakota\'s estimates for 25 measures of substance use and mental health based on the combined 2009 and 2010 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for South Dakota for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: mental-health, samhsa, sd-nsduh, south-dakota, substance-use
Organization: U.S. Department of Health & Human Services
Continuing medical education in Turkey: Recent developments

Background
          The Turkish Association of Medicine founded a Continuing Medical Education Accreditation Committee in 1993 to evaluate and accredit scientific meetings and publications. The aims of this project were to raise the standards of meetings and to introduce compulsory revalidation and re-certification for physicians in Turkey.
        
        
          Discussion
          Since the year 1994, 2348 applications to the Continuing Medical Education board have been made (mostly for scientific meetings), and 95% of these applications have been accepted. Physicians received 139.014 credits during this time. This number is increasing every year. Meeting organisers' demand for such a kind of evaluation is increasing, because participants increasingly request it.
        
        
          Summary
          Efforts for revalidation and re-certification of physicians have not been completely successful yet. In the near future the Co-ordination Council of Medical Speciality Societies is going to oblige member associations to establish speciality boards. This will be the first step to the conventional use of Continuing Medical Education credits in occupational evaluation. Time-limited re-certification of physicians is the principal goal of Turkish Medical Association. Efforts to implement this change in legislation are being made.

Tags: continuing-medical-education, medical-accreditation, nih, physician-revalidation, turkey-healthcare
Organization: U.S. Department of Health & Human Services
2020 Uniform Reporting System (URS) Table For Massachusetts

This is the 2020 Uniform Reporting System (URS) Output Tables for Massachusetts. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-data, massachusetts-data, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
VirOligo: a database of virus-specific oligonucleotides

VirOligo is a database of virus-specific oligonucleotides. The VirOligo database consists of two tables, Common data and Oligo data. The Oligo data table contains PCR primers and hybridization probes used for detection of viral nucleic acids and the Common data table contains the experimental conditions used in their detection. Each oligonucleotide entry contains links to PubMed, GenBank, NCBI Taxonomy databases and BLAST. As of July 2001, the VirOligo database contains a complete listing of oligonucleotides specific to viral agents associated with bovine respiratory disease that were published in English in peer-reviewed journals. The viruses are bovine herpes virus types 1, 3, 4 and 5, bovine viral diarrhea virus, bovine parainfluenza 3 virus, bovine respiratory syncytial virus, bovine adenovirus, bovine rhinovirus, bovine coronavirus, bovine reovirus, bovine enterovirus and alcelaphine herpesvirus-1. The VirOligo database is being expanded to other viruses and can be accessed through the Internet at http://viroligo.okstate.edu/.

Tags: bovine-respiratory-disease, nih, pcr-primers, viral-detection, virus-oligonucleotides
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Washington, 2013

This is a behavioral health report for the state of Washington. It uses the  National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment Services (NSSATS) to address the topics of youth substance use , youth mental health and treatment, adult mental health and treatment, substance use, substance use treatment for the years 2008 to 2012.

Tags: adult-mental-health, samhsa, substance-use-treatment, washington-behavioral-health, youth-substance-use
Organization: U.S. Department of Health & Human Services
Minneapolis: Drug-Related Emergency Department Visits, 2004-2011 - Adverse Reactions

Excel file with estimates, rates, relative standard errors, trends and confidence intervals, covering 2004-2011 for emergency department visits involving adverse reactions in the Minneapolis metropolitan area. It includes ED visits in which an adverse health consequence (e.g., side effects or an allergic reaction) resulted when taking prescription drugs, over-the-counter medications, or dietary supplements as prescribed or recommended.  This analytic category does not include drug misuse or abuse.File includes data for over 500 drugs, including illicit drugs, prescription and over-the-counter medications, dietary supplements, inhalants and alcohol.  Includes total visits, gender, age group, race/ethnicity, outcome of visit, drug combinations, number of drugs involved in visit, drug frequency, and drugs confirmed by toxicology.Additional detail is provided for illicit drugs, psychotherapeutic drugs, central nervous system (CNS) drugs, respiratory drugs and cardiovascular drugs.

Tags: adverse-drug-events, drug-reactions, emergency-department-visits, pharmacoepidemiology, samhsa
Organization: U.S. Department of Health & Human Services
Blending science and compassion: The 30th educational symposium of the Society of Critical Care Medicine, San Francisco, USA, 10-14 February 2001

Blending science and compassion: The 30th educational symposium of the Society of Critical Care Medicine, San Francisco, USA, 10-14 February 2001

Tags: critical-care, intensive-care, medical-symposium, nih, sccm
Organization: U.S. Department of Health & Human Services
Trend Tables (Standard Errors and P Values) - 7.1 to 7.45

These detailed tables show standard errors for trends in totals and prevalence estimates of illicit drug use, risk and protective factors, substance initiation, substance dependence/abuse, and need/receipt of substance use treatment from the 2012 National Survey on Drug Use and Health (NSDUH). Substances examined include illicit drugs (e.g., marijuana, cocaine, heroin, hallucinogens (including LSD, PCP, Ecstasy, Ketamine, DMT/AMT/Foxy, Salvia divinorum), inhalants, and the nonmedical use of prescription-type pain relievers (including OxyContin), tranquilizers, stimulants (Adderall), sedatives (GHB, Ambien), non-prescription cold medicine, alcohol, and tobacco products (including cigarettes, smokeless tobacco, cigars, pipes). Standard errors are provided for totals and estimates of lifetime, past year, and past month use by age group, gender, race/ethnicity, education level, employment status, and geographic area.

Tags: drug-trends, nsduh-data, samhsa, standard-errors, substance-use
Organization: U.S. Department of Health & Human Services
Reliability and cultural applicability of the Greek version of the International Personality Disorders Examination.

Background
          The International Personality Disorders Examination (IPDE) constitutes the proposal of the WHO for the reliable diagnosis of personality disorders (PD). The IPDE assesses pathological personality and is compatible both with DSM-IV and ICD-10 diagnosis. However it is important to test the reliability and cultural applicability of different IPDE translations.
        
        
          Methods
          Thirty-one patients (12 male and 19 female) aged 35.25 ± 11.08 years, took part in the study. Three examiners applied the interview (23 interviews of two and 8 interviews of 3 examiners, that is 47 pairs of interviews and 70 single interviews). The phi coefficient was used to test categorical diagnosis agreement and the Pearson Product Moment correlation coefficient to test agreement concerning the number of criteria met.
        
        
          Results
          Translation and back-translation did not reveal specific problems. Results suggested that reliability of the Greek translation is good. However, socio-cultural factors (family coherence, work environment etc) could affect the application of some of the IPDE items in Greece. The diagnosis of any PD was highly reliable with phi >0.92. However, diagnosis of non-specfic PD was not reliable at all (phi close to 0) suggesting that this is a true residual category. Dianosis of specific PDs were highly reliable with the exception of schizoid PD. Diagnosis of antisocial and Borderline PDs were perfectly reliable with phi equal to 1.00.
        
        
          Conclusions
          The Greek translation of the IPDE is a reliable instrument for the assessment of personality disorder but cultural variation may limit its applicability in international comparisons.

Tags: cultural-adaptation, diagnostic-reliability, ipde-greek-version, nih, personality-disorders
Organization: U.S. Department of Health & Human Services
Compound 525293: 2-(1-Chloroethylidene)hexanal

Chemical compound data from PubChem database. IUPAC Name: 2-(1-chloroethylidene)hexanal. Molecular Formula: C8H13ClO. Molecular Weight: 160.64. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2013 CMHS Uniform Reporting System (URS) Tables for Maryland

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Tables for Maryland for 2013. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program.  State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, outcome-measures, samhsa, urs-data
Organization: U.S. Department of Health & Human Services
Alabama 2016 Potential Areas for Addressing Service Gaps for Opioid Treatment

The purpose of the medication-assisted treatment (MAT) facility maps is to identify areas on a state-by-state basis that may be potentially underserved by existing treatment facilities. The maps are created with a methodology that seeks to include the highest potential need areas from individual counties so that county-level stakeholders are also informed. The maps are meant to be used as a tool for policy makers to determine potentially underserved areas—not as a definitive representation of these areas.

Tags: alabama-opioids, mat-access, opioid-treatment, samhsa, service-gap-analysis
Organization: U.S. Department of Health & Human Services
2019 Uniform Reporting System (URS) Table for Montana

These are the 2019 Uniform Reporting System (URS) Output Tables for Montana. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: mental-health-services, montana, national-outcome-measures, samhsa, urs-data
Organization: U.S. Department of Health & Human Services
Protection against cartilage and bone destruction by systemic
		  interleukin-4 treatment in established murine type II collagen-induced
		  arthritis

Destruction of cartilage and bone are hallmarks of human rheumatoid
			 arthritis (RA), and controlling these erosive processes is the most challenging
			 objective in the treatment of RA. Systemic interleukin-4 treatment of
			 established murine collagen-induced arthritis suppressed disease activity and
			 protected against cartilage and bone destruction. Reduced cartilage pathology
			 was confirmed by both decreased serum cartilage oligomeric matrix protein
			 (COMP) and histological examination. In addition, radiological analysis
			 revealed that bone destruction was also partially prevented. Improved
			 suppression of joint swelling was achieved when interleukin-4 treatment was
			 combined with low-dose prednisolone treatment. Interestingly, synergistic
			 reduction of both serum COMP and inflammatory parameters was noted when
			 low-dose interleukin-4 was combined with prednisolone. Systemic treatment with
			 interleukin-4 appeared to be a protective therapy for cartilage and bone in
			 arthritis, and in combination with prednisolone at low dosages may offer an
			 alternative therapy in RA.

Tags: bone-destruction, cartilage-protection, collagen-induced-arthritis, interleukin-4-treatment, nih
Organization: U.S. Department of Health & Human Services
2018 Uniform Reporting System (URS) Table for Nebraska

This is the 2018 Uniform Reporting System (URS) Output Tables for Nebraska. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-data, mental-health-services, national-outcome-measures, nebraska, samhsa
Organization: U.S. Department of Health & Human Services