AndreaBozzo/ceres-open-data-index huggingface dataset:
Compound 527219: 8a-methyl-5-methylidene-3-propan-2-yl-2,3,4,6,7,8-hexahydro-1H-naphthalen-4a-ol

Chemical compound data from PubChem database. IUPAC Name: 8a-methyl-5-methylidene-3-propan-2-yl-2,3,4,6,7,8-hexahydro-1H-naphthalen-4a-ol. Molecular Formula: C15H26O. Molecular Weight: 222.37. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Regulation of prostaglandin synthesis and cell adhesion by a tryptophan catabolizing enzyme

Background
          The tryptophan catabolizing enzyme, indoleamine 2,3, dioxygenase (IDO) is one of two mammalian enzymes, which can catabolize the rarest essential amino acid, tryptophan. IDO is inducible by cytokines such as interferon-γ and plays a role in inflammation and maternal tolerance of fetal allografts, although its exact mode of action is unclear. Therefore, we investigated the circumstances under which IDO is expressed in vitro together with the effects of overexpression of IDO on the growth and morphology of cells.
        
        
          Results
          Overexpression of IDO in the murine macrophage cell line RAW 264.7 and the murine fibrosarcoma cell line MC57, resulted in the growth of macroscopic cell foci, with altered cell adhesion properties. The expression of IDO was also detected during adhesion of wild type, nontransfected cells in tissue culture to standard cell growth substrates. Inhibition of this expression, likewise resulted in alterations in cell adhesion. Overexpression of IDO or inhibition of endogenous IDO expression was accompanied by changes in metalloproteinase expression and also in the expression and activity of the cyclooxygenase enzymes. In the case of RAW cells, IDO effects on cell growth could be reversed by adding back prostaglandins.
        
        
          Conclusions
          These results suggest that catabolism of the rarest essential amino acid may regulate processes such as cell adhesion and prostaglandin synthesis.

Tags: cell-adhesion, indoleamine-23-dioxygenase, nih, prostaglandin-synthesis, tryptophan-catabolism
Organization: U.S. Department of Health & Human Services
Treatment Episode Data Set (TEDS) 2022: Admissions to and Discharges From Substance Use Treatment Services Reported By Single State Agencies

This report presents the total number of admissions to and discharges from substance use treatment services in 2022 by demographics, National Outcome Measures (NOMs), morbidity status, and the top six primary substances by geographic distribution. This report also presents the total number of admissions to and discharge from substance use treatment services by demographics and the top six substances in 2018-2022. The NOMs presented in this report include stability in housing, employment status, criminal justice involvement, social support, retention in treatment, and abstinence. Data include records for treatment admissions and discharges that were received and processed through October 17, 2023.

Tags: national-outcome-measures, samhsa, substance-abuse, substance-use-treatment, teds-admissions-discharges
Organization: U.S. Department of Health & Human Services
Efficacy and adverse effects of intravenous lignocaine therapy in fibromyalgia syndrome

Background
          To investigate the effects of intravenous lignocaine infusions (IV lignocaine) in fibromyalgia.
        
        
          Methods
          Prospective study of the adverse effects of IV lignocaine in 106 patients with fibromyalgia; retrospective questionnaire study of the efficacy of IV lignocaine in 50 patients with fibromyalgia.
        
        
          Results
          Prospective study: Two major (pulmonary oedema and supraventricular tachycardia) and 42 minor side-effects were reported. None had long-term sequelae. The commonest was hypotension (17 cases). Retrospective study: Pain and a range of psychosocial measures (on single 11-point scales) improved significantly after treatment. There was no effect of the treatment on work status. The average duration of pain relief after the 6-day course of treatment was 11.5 ± 6.5 weeks.
        
        
          Conclusions
          Intravenous lignocaine appears to be both safe and of benefit in improving pain and quality of life for patients with fibromyalgia. This needs to be confirmed in prospective randomised controlled trials.

Tags: fibromyalgia-syndrome, intravenous-lidocaine, nih, pain-management, treatment-efficacy
Organization: U.S. Department of Health & Human Services
National Mental Health Services Survey (N-MHSS): 2010

This report presents results from the 2010 National Mental Health Services Survey (N-MHSS), a census of all known mental health treatment facilities within the U.S. and territories.  N-MHSS collects facility-specific characteristics, types of services and specially-designed programs/services offered, and payment/funding sources.

Tags: behavioral-health-services, mental-health-facilities, mental-health-survey, samhsa, treatment-programs
Organization: U.S. Department of Health & Human Services
Detroit: Drug-Related Emergency Department Visits, 2004-2011 - Illicits (excluding alcohol)

Excel file with estimates, rates, relative standard errors, trends and confidence intervals for all drug-related emergency department (ED) visits involving illicit drugs for the Detroit metropolitan area, covering 2004-2011. These visits involve the use of drugs that have limited or no therapeutic value and are generally illegal if taken without a prescription. It also includes visits involving the inhalation of substances for their psychoactive properties (e.g., sniffing model airplane glue).

Tags: detroit-metro-area, drug-related-ed-visits, emergency-department-data, illicit-drug-use, samhsa
Organization: U.S. Department of Health & Human Services
2017 Uniform Reporting System (URS) Table for Wyoming

This is the 2017 Uniform Reporting System (URS) Output Tables for Wyoming. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: evidence-based-practices, mental-health-services, national-outcome-measures, samhsa, utilization-measures
Organization: U.S. Department of Health & Human Services
Drug-related Suicide Attempts by Middle-aged Adults Likely to Involve Alcohol Combined with Drugs

This report describes emergency department (ED) visits involving drug-related suicide attempts using data from the 2011 Drug Abuse Warning Network (DAWN). The ED visits for suicide attempts by middle-aged adults were more likely to involve alcohol combined with other drugs compared with other drug-related visits.

Tags: alcohol-drug-use, emergency-department, middle-aged-adults, samhsa, suicide-attempts
Organization: U.S. Department of Health & Human Services
Compound 525435: 3,5-Dithia-1-octene

Chemical compound data from PubChem database. IUPAC Name: 1-(ethenylsulfanylmethylsulfanyl)propane. Molecular Formula: C6H12S2. Molecular Weight: 148.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Engaging Youth in Information Systems Design Toolkit

This technical assistance document provides guidance to title IV-E agencies about engaging and involving youth in foster care and young adults formerly in foster care (youth and young adults) in the design and development of child welfare information systems, websites, or applications. In addition, the document discusses overcoming barriers with identifying and engaging youth and young adults in the software development process.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: care, foster, guidance, instruction, policy
Organization: U.S. Department of Health & Human Services
Flow cytometry analysis of the effect of allopurinol and the dinitroaniline compound (Chloralin) on the viability and proliferation of

Background
          Leishmaniasis is a major parasitic disease in the tropical regions. However, Leishmania infantum has recently emerged as a very important cause of opportunistic infections for individuals positive for human immunodeficiency virus (HIV). However, there is a lack of in vitro tests for assessing the effect of anti-parasitic drugs on the viability and proliferation of Leishmania infantum. The aim of this study is to assess the efficacy of anti-parasitic drugs like allopurinol and Chloralin on the viability and proliferation of L. infantum promastigotes by utilizing two complementary flow cytometric approaches after exposure of the promastigotes to various concentrations of the drugs.
        
        
          Results
          The density of the cultures in the presence and absence of allopurinol was determined by haemocytometer enumeration. The two flow cytometric approaches used to monitor the drug effect were: (i) a quantitative method to measure cell division using 5-,6-carboxyfluorescein diacetate succinimidyl ester (CFSE) staining and (ii) evaluation of cell viability by dual-staining with the membrane-permeable nuclear stain, SBRY-14 and propidium iodide. It was found that concentrations of allopurinol above 50 μg/ml yielded a clear decrease in the proliferation rate of the promastigotes. However, the viability results showed that about 46.8% of the promastigotes incubated in the presence of 800 μg/ml of allopurinol were still alive after 96 hours. In sharp contrast, more than 90% of promastigotes treated with Chloralin 10 μM (2.7 μg/ml) were dead after 48 hours of treatment. These flow cytometric findings suggest that allopurinol has a leishmaniostatic effect while the dinitroaniline compound (Chloralin) has a leishmaniocidal effect against promastigotes.
        
        
          Conclusions
          The flow cytometric data on proliferation and viability were consistent with results obtained from haemocytometer counts and allowed us to develop a model for assessing in vitro the effects of medicaments like allopurinol and chloralin on L. infantum promastigotes on a cellular level.

Tags: allopurinol-effect, anti-parasitic-drugs, flow-cytometry, leishmania-infantum, nih
Organization: U.S. Department of Health & Human Services
Compound 527249: 2,2-Dimethyl-3-(3-methyl-4-penten-1-yl)oxirane

Chemical compound data from PubChem database. IUPAC Name: 2,2-dimethyl-3-(3-methylpent-4-enyl)oxirane. Molecular Formula: C10H18O. Molecular Weight: 154.25. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 528522: Hexadecane, 5-nonyl

Chemical compound data from PubChem database. IUPAC Name: 10-butylhenicosane. Molecular Formula: C25H52. Molecular Weight: 352.7. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 528509: Hexadecane, 3-propyl

Chemical compound data from PubChem database. IUPAC Name: 4-ethylheptadecane. Molecular Formula: C19H40. Molecular Weight: 268.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 525446: 3-Methyl-1,2-dithiolane

Chemical compound data from PubChem database. IUPAC Name: 3-methyldithiolane. Molecular Formula: C4H8S2. Molecular Weight: 120.2. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2011 State Profile — Vermont

This is a National Survey of Substance Abuse Treatment Services (N-SSATS) data table showing state profile for Vermont in 2011. N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 States, the District of Columbia, and other U.S. jurisdictions.

Tags: n-ssats, samhsa, substance-abuse-treatment, treatment-facilities, vermont
Organization: U.S. Department of Health & Human Services
Cytokine mRNA and protein expression in primary-culture and repeated-passage synovial fibroblasts from patients with rheumatoid arthritis

Constitutive mRNA expression and secretion of proinflammatory and anti-inflammatory cytokines was comparatively analyzed in rheumatoid arthritis (RA) synovial fibroblasts (SFB), isolated from primary culture or derived by repeated passage; normal-skin fibroblasts were used as controls. First-passage RA-SFB (n = 3) secreted large amounts of IL-6 (15,800 ± 2,110 pg/ml; mean ± SEM), but only limited amounts of tumor necrosis factor (TNF)-α (22.1 ± 1.1 pg/ml) or IL-10 (35.7 ± 34.2 pg/ml; only one of three samples was positive). IL-1β, IL-15, and IL-18 were not detectable at the protein level and showed very low mRNA levels by semiquantitative RT-PCR. In repeated-passage RA-SFB (tenth passage), protein secretion was significantly lower for IL-6 (one-twentieth of the initial level) and TNF-α (two-thirds), and markedly reduced for IL-10 (one-quarter, with only one of three samples positive). While the decrease of IL-10 protein from first to tenth passage was paralleled by a corresponding decrease of mRNA, the relative mRNA levels for IL-6 and TNF-α were actually increased (20-fold and 300-fold, respectively), indicating post-transcriptional and/or post-translational regulation of these cytokines. Due to highly variable levels among individual patients, however, no significant differences were observed for any cytokine mRNA between primary-culture and repeated-passage RA-SFB (ninth passage). Likewise, no significant differences were detectable between RA-SFB and normal-skin fibroblasts (primary-culture and repeated-passage). By producing high amounts of IL-6 and limited amounts of TNF-α, RA-SFB may contribute to the (im)balance of proinflammatory and anti-inflammatory cytokines in the inflamed joint.

Tags: cytokine-expression, il-6, nih, rheumatoid-arthritis, synovial-fibroblasts
Organization: U.S. Department of Health & Human Services
Platelet count and Interleukin 6 Gene polymorphism in healthy subjects

Background
          Interleukin 6 (IL-6) is thought to play important roles in the development of reactive thrombocytosis caused by inflammation by its stimulatory effect on megakaryocytopoiesis. A G/C polymorphism of the IL-6 gene at position -174 has been found to be associated to different transcription rates. Specifically, subjects with the CC genotype showed lower plasma IL-6 levels compared with GC or GG subjects. Given this difference in transcription rates of IL-6 we speculated on different platelet count according to this IL-6 polymorphism.
        
        
          Methods
          The G/C polymorphism of the IL-6 gene at position -174, serum IL-6 concentration and platelet count were prospectively analyzed in 59 (25 women) consecutive healthy subjects.
        
        
          Results
          Subjects who were homozygotes for the C allele at position -174 of the IL-6 gene (Sfa NI genotype) showed significantly lower platelet count than carriers of the G allele, despite similar age, sex, body mass index and proportion of smokers (205400 ± 44088 vs 239818 ± 60194, p = 0.047). This was in parallel to differences in peripheral white blood cell count (5807 ± 1671 vs 6867 ± 1192 × 109/ml, p = 0.01).
        
        
          Conclusion
          This is the first description, to our knowledge, of a genetical influence on basal platelet counts, which appears to be partially dependent on a polymorphism of the IL-6 gene, even in the absence of inflammation.

Tags: genetic-association-study, il-6-polymorphism, nih, platelet-count, thrombocytosis
Organization: U.S. Department of Health & Human Services
2010 State Profile — Arizona

This state profile includes data from facilities in Arizona that reported to N-SSATS for the survey reference date March 31, 2010. Data were collected on the location, characteristics, services offered, and number of clients in treatment at alcohol and drug abuse treatment facilities (both public and private) in Arizona. In Arizona, 214 substance abuse treatment facilities were included in the 2010 N-SSATS, reporting that there were 27,599 clients in substance abuse treatment on March 31, 2010. The survey response rate in Arizona was 88.3%.

Tags: alcohol-drug-abuse, arizona, n-ssats, samhsa, substance-abuse-treatment
Organization: U.S. Department of Health & Human Services
2013 CMHS Uniform Reporting System (URS) Tables for Kentucky

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Tables for Kentucky for 2013. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program.  State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant, kentucky, mental-health-services, outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Compound 525242: N''-(3-methyl-phenyl)-N,N,N',N'-tetramethyl-guanidine

Chemical compound data from PubChem database. IUPAC Name: 1,1,3,3-tetramethyl-2-(3-methylphenyl)guanidine. Molecular Formula: C12H19N3. Molecular Weight: 205.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 525280: N'-Hexyl-N,N-dimethyl-acetamidine

Chemical compound data from PubChem database. IUPAC Name: N'-hexyl-N,N-dimethylethanimidamide. Molecular Formula: C10H22N2. Molecular Weight: 170.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
First isolation of the enterohaemorrhagic

Background
          Enterohaemorrhagic Escherichia coli (EHEC) is considered to be common cause of haemorrhagic colitis (HC), thrombotic thrombocytopenic purpura and haemolytic uraemic syndrome (HUS) in humans. In a previous paper, we have demonstrated that EHEC are commonly found in the intestines of livestock. Infections in humans are, in part, a consequence of consumption of undercooked meat or raw milk. Argentina has one of the highest records of HUS (300–400 cases/year; 22/100,000 children under 4 years of age). The aim of this work is to communicate the first isolation of O145:H-from cattle in this country and characterize the virulence cassette, providing useful information to evaluate the risk of foodborne transmission of this emergent non-O157:H7 serotype.
        
        
          Results
          EHEC O145:H- was isolated from cattle in an Argentinian feedlot. Pheno- and genotype of nine strains were characterized, corresponding to several virulence cassettes: VT2+eaeA+ Mp+ (n = 5), VT2+eaeA+ (n = 1), VT1+eaeA+ Mp+ (n = 2), and VT1+eaeA+ (n = 1). Strains isolated from the same animal were considered only when they showed a different virulence pattern. The clonal relationship was studied by RAPD. Strains were distributed in two RAPD profiles, which corresponded to the presence of either, VT1+ or VT2+ genotype. No difference was detected by RAPD analysis between Mp+ or Mp- strains.
        
        
          Conclusions
          This was the first isolation of EHEC O145:H- serotype in Argentina enlarging the list of non-O157:H7 serotypes isolated from cattle in this country by us. All O145:H-strains carried several virulence factors which allow us to predict their potential ability to develop haemolytic uraemic syndrome in humans.

Tags: cattle-ehec, ehec-o145, foodborne-transmission, hemolytic-uremic-syndrome, nih
Organization: U.S. Department of Health & Human Services
Prevalence estimates and 95% confidence intervals for persons aged 18 or older are shown

This report presents trends of estimates for measures of substance use and mental health based on the combined 2002 and 2003 and the combined 2009 and 2010 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for those aged 18 or older.

Tags: adult-prevalence, mental-health, samhsa, substance-use, suicidal-ideation
Organization: U.S. Department of Health & Human Services
Biomechanical evaluation of immediate stability with rectangular versus cylindrical interbody cages in stabilization of the lumbar spine

Background
          Recent cadaver studies show stability against axial rotation with a cylindrical cage is marginally superior to a rectangular cage. The purpose of this biomechanical study in cadaver spine was to evaluate the stability of a new rectangular titanium cage design, which has teeth similar to the threads of cylindrical cages to engage the endplates.
        
        
          Methods
          Ten motion segments (five L2-3, five L4-5) were tested. From each cadaver spine, one motion segment was fixed with a pair of cylindrical cages (BAK, Sulzer Medica) and the other with paired rectangular cages (Rotafix, Corin Spinal). Each specimen was tested in an unconstrained state, after cage introduction and after additional posterior translaminar screw fixation. The range of motion (ROM) in flexion-extension, lateral bending, and rotation was tested in a materials testing machine, with +/- 5 Nm cyclical load over 10 sec per cycle; data from the third cycle was captured for analysis.
        
        
          Results
          ROM in all directions was significantly reduced (p < 0.05) with both types of cages. There was no significant difference in reduction of ROM in flexion-extension (p = 0.6) and rotation (p = 0.92) between the two cage groups, but stability in lateral bending was marginally superior with the rectangular cages (p = 0.11). Additional posterior fixation further reduced the ROM significantly (p < 0.05) in most directions in both cage groups, but did not show any difference between the cage groups.
        
        
          Conclusions
          There was no significant difference in immediate stability in any direction between the threaded cylindrical cage and the new design of the rectangular cage with endplate teeth.

Tags: biomechanical-stability, cadaver-study, interbody-fusion, lumbar-spine, nih
Organization: U.S. Department of Health & Human Services