AndreaBozzo/ceres-open-data-index huggingface dataset:
Notch signalling is linked to epidermal cell differentiation level in basal cell carcinoma, psoriasis and wound healing

Background
          Epidermal homeostasis involves the monitoring of continuous proliferative and differentiative processes as keratinocytes migrate from the basal layer to the skin surface. Recently, differentiation of epidermal stem cells was shown to be promoted by the Notch pathway. This pathway is characterised by cell-cell interactions between transmembrane proteins and was first implicated in lateral inhibition, patterning and cell binary choices during embryogenesis.
        
        
          Methods
          By in situ hybridisation, we investigated the in vivo expression of related genes, namely; Notch 1–3, Delta 1, Jagged 1, Lunatic Fringe, Radical Fringe and Manic Fringe during keratinocyte proliferation and differentiation in humans in basal cell carcinoma, psoriasis and in wound healing experiments, compared with normal adult skin.
        
        
          Results
          We show that the highest level of transcription of these genes is in the basal cell layer of non-lesional skin. Conversely, when keratinocytes were hyperproliferating, as in basal cell carcinoma, psoriasis, and during the first step of re-epithelialisation, expression was weak or non-existent. Furthermore, normal levels of transcripts were rescued in psoriatic plaques when treated by phototherapy, as well as in newly regenerated stratified epidermis following wound healing.
        
        
          Conclusion
          The Notch signalling involved in the differentiation programme of normal adult human epidermis is altered under experimental conditions and pathologies which modify this programme.

Tags: basal-cell-carcinoma, nih, notch-signaling, psoriasis, wound-healing
Organization: U.S. Department of Health & Human Services
Arizona (AZ)

This report uses 2008 to 2010 National Survey on Drug Use and Health (NSDUH) to assess past year alcohol use disorder and illicit drug use disorder among persons aged 12 or older for Arizona overall and for substate regions within Arizona. Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE).

Tags: alcohol-abuse, mental-health-arizona, nsduh-data, samhsa, substance-use-disorder
Organization: U.S. Department of Health & Human Services
Physical mapping of genes in somatic cell radiation hybrids by comparative genomic hybridization to cDNA microarrays

Background
          Somatic cell mutants can be informative in the analysis of a wide variety of cellular processes. The use of map-based positional cloning strategies in somatic cell hybrids to analyze genes responsible for recessive mutant phenotypes is often tedious, however, and remains a major obstacle in somatic cell genetics. To fulfill the need for more efficient gene mapping in somatic cell mutants, we have developed a new DNA microarray comparative genomic hybridization (array-CGH) method that can rapidly and efficiently map the physical location of genes complementing somatic cell mutants to a small candidate genomic region. Here we report experiments that establish the validity and efficacy of the methodology.
        
        
          Results
          CHO cells deficient for hypoxanthine:guanine phosphoribosyl transferase (HPRT) were fused with irradiated normal human fibroblasts and subjected to HAT selection. Cy5-labeled genomic DNA from the surviving hybrids containing the HPRT gene was mixed with Cy3-labeled genomic DNA from normal CHO cells and hybridized to a microarray containing 40,185 cDNAs, representing 29,399 genes (UniGene clusters). The DNA spots with the highest Cy5:Cy3 fluorescence ratios corresponded to a group of genes mapping within a 1 Mb interval centered near position 142.7 Mb on the X chromosome, the genomic location of HPRT.
        
        
          Conclusion
          The results indicate that our physical mapping method based on radiation hybrids and array-CGH should significantly enhance the speed and efficiency of positional cloning in somatic cell genetics.

Tags: comparative-genomic-hybridization, dna-microarray, gene-mapping, nih, somatic-cell-hybrids
Organization: U.S. Department of Health & Human Services
Abduction paresis with rostral pontine and/or mesencephalic lesions: Pseudoabducens palsy and its relation to the so-called posterior internuclear ophthalmoplegia of Lutz

Background
          The existence of a prenuclear abduction paresis is still debated.
        
        
          Methods
          In a retrospective design, we identified 22 patients with isolated unilateral (n = 20) or bilateral (n = 2) abduction paresis and electrophysiologic abnormalities indicating rostral pontine and/or mesencephalic lesions. Another 11 patients had unilateral abduction paresis with additional ocular motor abnormalities indicating midbrain dysfunction. Eight of these 11 patients also had electrophysiological abnormalities supporting this location. Electrophysiological examinations in all patients included masseter and blink reflexes (MassR, BlinkR), brainstem auditory evoked potentials (BAEP), and direct current elctro-oculography (EOG).
        
        
          Results
          Unilateral MassR abnormalities in patients with unilateral abduction paresis were seen in 17 patients and were almost always (in 16 of 17 patients) on the side of the abduction paresis. Another 11 patients had bilateral MassR abnormalities. BlinkR was always normal. EOG disclosed slowed abduction saccades in the non-paretic eye in 6 patients and slowed saccades to the side opposite to the abduction paresis in another 5 patients. Re-examinations were done in 27 patients showing normalization or improvement of masseter reflex abnormalities in 18 of 20 patients and in all patients with EOG abnormalities. This was always associated with clinical improvement.
        
        
          Conclusions
          Electrophysiologically documented or clinically evident rostral pontine and/or mesencephalic lesions in our patients exclude an infranuclear intrapontine 6th nerve lesion and indicate the existence of an abduction paresis of prenuclear origin. An increased tone of the antagonistic medial rectus muscle during lateral gaze either by abnormal convergence or impaired medial rectus inhibition seems most likely.

Tags: abducens-palsy, brainstem-lesions, electrophysiology, nih, ocular-motility
Organization: U.S. Department of Health & Human Services
2017 Uniform Reporting System (URS) Table for Iowa

This is the 2017 Uniform Reporting System (URS) Output Tables for Iowa. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: iowa, mental-health-services, national-outcome-measures, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
National Directory of Drug and Alcohol Abuse Treatment Facilities - 1998

The National Directory of Drug and Alcohol Abuse Treatment Programs 199 lists federal, state, local, and private facilities that provide substance abuse treatment services. The directory includes treatment facilities that are licensed, certified, or otherwise approved for inclusion in the directory by their state substance abuse agencies and that responded to the 1997 National Survey of Substance Abuse Treatment Services (N-SSATS). The information about each facility that appears in this directory was provided by that facility in response to the 1997 N-SSATS. The Substance Abuse and Mental Health Services Administration (SAMHSA) conducts the N-SSATS annually.

Tags: alcohol-abuse, drug-abuse, samhsa, substance-abuse-treatment, treatment-facilities
Organization: U.S. Department of Health & Human Services
Tribal Federal Medical Assistance Percentage Reference Table for FYs 2018-2019

This report provides the Federal Medical Assistance Percentages (FMAPs) for fiscal years 2018 and 2019 as well as relevant per capita income data for tribes expressing interest in operating title IV-E programs.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: affair, data, fiscal, social, tribal
Organization: U.S. Department of Health & Human Services
Dopaminergic neurons in the brain and dopaminergic innervation of the albumen gland in mated and virgin helisoma duryi (mollusca: pulmonata)

Background
          Dopamine was shown to stimulate the perivitelline fluid secretion by the albumen gland. Even though the albumen gland has been shown to contain catecholaminergic fibers and its innervation has been studied, the type of catecholamines, distribution of fibers and the precise source of this neural innervation has not yet been deduced. This study was designed to address these issues and examine the correlation between dopamine concentration and the sexual status of snails.
        
        
          Results
          Dopaminergic neurons were found in all ganglia except the pleural and right parietal, and their axons in all ganglia and major nerves of the brain. In the albumen gland dopaminergic axons formed a nerve tract in the central region, and a uniform net in other areas. Neuronal cell bodies were present in the vicinity of the axons. Dopamine was a major catecholamine in the brain and the albumen gland. No significant difference in dopamine quantity was found when the brain and the albumen gland of randomly mating, virgin and first time mated snails were compared.
        
        
          Conclusions
          Our results represent the first detailed studies regarding the catecholamine innervation and quantitation of neurotransmitters in the albumen gland. In this study we localized catecholaminergic neurons and axons in the albumen gland and the brain, identified these neurons and axons as dopaminergic, reported monoamines present in the albumen gland and the brain, and compared the dopamine content in the brain and the albumen gland of randomly mating, virgin and first time mated snails.

Tags: albumen-gland, dopamine-concentration, dopaminergic-neurons, helisoma-duryi, nih
Organization: U.S. Department of Health & Human Services
How People Obtain the Prescription Pain Relievers They Misuse

This short report uses 2013 to 2014 National Survey on Drug Use and Health (NSDUH) to assess sources of misused prescription pain relievers in the United States overall, by demographic subgroups, and by three types of user: (1) recent initiates, (2) frequent users, and (3) occasional users.

Tags: drug-misuse, nsduh-data, opioid-abuse, prescription-pain-relievers, samhsa
Organization: U.S. Department of Health & Human Services
2011 CMHS Uniform Reporting System (URS) Output Tables for North Dakota

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2011. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, national-outcome-measures, north-dakota, samhsa
Organization: U.S. Department of Health & Human Services
Table 25. Any Mental Illness in the Past Year among Persons Aged 18 or Older, by State and Substate Regions: Percentages, Annual Averages Based on 2010, 2011, and 2012 NSDUHs

Table 25. Any Mental Illness in the Past Year among Persons Aged 18 or Older, by State and Substate Regions: Percentages, Annual Averages Based on 2010, 2011, and 2012 NSDUHs

Tags: mental-health, mental-illness-adults, nsduh-survey, samhsa, state-level-data
Organization: U.S. Department of Health & Human Services
Rhinocerebral mucormycosis treated with 32 gram liposomal amphotericin B and incomplete surgery: a case report

Background
          Mucormycosis (or zygomycosis) is the term for infection caused by fungi of the order Mucorales. Mucoraceae may produce severe disease in susceptible individuals, notably patients with diabetes and leukemia. Rhinocerebral mucormycosis most commonly manifests itself in the setting of poorly controlled diabetes, especially with ketoacidosis.
        
        
          Case Presentation
          A 31-year-old diabetic man presented to the outpatient clinic with the following signs and symptoms: headache, periorbital pain, swelling and loss of vision in the right eye. On physical examination his right eye was red and swollen. There was periorbital cellulitis and the conjunctiva was edematous. KOH preparation of purulent discharge showed broad, ribbonlike, aseptate hyphae when examined under a fluorescence microscope. Cranial MRI showed involvement of the right orbit, thrombosis in cavernous sinus and infiltrates at ethmoid and maxillary sinuses. Mucormycosis was diagnosed based on these findings. Amphotericin B (AmBisome®; 2 mg/kg.d) was initiated after the test doses. Right orbitectomy and right partial maxillectomy were performed; the lesions in ethmoid and maxillary sinuses were removed. The duration of the liposomal amphotericin B therapy was approximately 6 months and the total dose of liposomal amphotericin B used was 32 grams. Liposomal amphotericin B therapy was stopped six months later and oral fluconazole was started.
        
        
          Conclusions
          Although a total surgical debridement of the lesions could not be performed, it is remarkable that regression of the disease could be achieved with medical therapy alone.

Tags: diabetic-ketoacidosis, fungal-infection, liposomal-amphotericin-b, nih, rhinocerebral-mucormycosis
Organization: U.S. Department of Health & Human Services
2018 Uniform Reporting System (URS) Table for Oklahoma

This is the 2018 Uniform Reporting System (URS) Output Tables for Oklahoma. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: mental-health-services, national-outcome-measures, oklahoma, samhsa, substance-abuse-treatment
Organization: U.S. Department of Health & Human Services
Table 2. Marijuana Use in the Past Year among Persons Aged 12 or Older, by State and Substate Regions: Percentages, Annual Averages Based on 2008, 2009, and 2010 NSDUHs

This table presents the 2008 to 2010 National Survey on Drug Use and Health (NSDUH) estimates of past year marijuana use by those aged 12 or older by State and substate regions.

Tags: marijuana-use, nsduh-data, samhsa, substance-use, youth-substance-use
Organization: U.S. Department of Health & Human Services
Tribal TANF Work Participation Rates

Reports show work participation rate targets and actual rates achieved for Tribal TANF recipient families, reported by Tribe and fiscal year.

<b>Units of Response: </b>Tribes

<b>Type of Data: </b>Administrative

<b>Tribal Data: </b>Yes

<b>COVID-19 Data: </b>No

<b>Periodicity: </b>Annual

<b>SORN: </b>https://www.federalregister.gov/documents/2015/04/02/2015-07440/privacy-act-of-1974-system-of-records-notice

<b>Data Use Agreement: </b>https://www.icpsr.umich.edu/rpxlogin

<b>Data Use Agreement Location: </b>Not Applicable

<b>Equity Indicators: </b>Indigenous Population

<b>Granularity: </b>Tribe

<b>Spatial: </b>Tribes

<b>Geocoding: </b>Tribe

Tags: children-and-families, family-assistance
Organization: U.S. Department of Health & Human Services
Comparison of 2008-2010 and 2014-2016 NSDUH Substate Region Estimates

Tables showing the 2008-2010 and 2014-2016 substate area estimates and 95 percent Bayesian confidence intervals along with an indication of statistical significance of the difference.

Tags: behavioral-health, mental-health, nsduh, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Compound 525194: Chloromethyl 2-chlorohexanoate

Chemical compound data from PubChem database. IUPAC Name: chloromethyl 2-chlorohexanoate. Molecular Formula: C7H12Cl2O2. Molecular Weight: 199.07. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 525570: N,N-Dimethyl-N'-(3-ethoxyphenyl)-p-chlorobenzamidine

Chemical compound data from PubChem database. IUPAC Name: 4-chloro-N'-(3-ethoxyphenyl)-N,N-dimethylbenzenecarboximidamide. Molecular Formula: C17H19ClN2O. Molecular Weight: 302.8. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 527310: Methyl 1,8-diethyl-1,3,4,9-tetrahydropyrano(3,4-b)indole-1-acetate

Chemical compound data from PubChem database. IUPAC Name: methyl 2-(1,8-diethyl-4,9-dihydro-3H-pyrano[3,4-b]indol-1-yl)acetate. Molecular Formula: C18H23NO3. Molecular Weight: 301.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Table 13. Tobacco Product Use in the Past Month, by Age Group and State: Percentages, Annual Averages Based on 2013 and 2014 NSDUHs

Table 13. Tobacco Product Use in the Past Month, by Age Group and State: Percentages, Annual Averages Based on 2013 and 2014 NSDUHs

Tags: nsduh-data, samhsa, state-level-data, tobacco-use, youth-tobacco
Organization: U.S. Department of Health & Human Services
2010-2011 State-specific tables of prevalence estimates and estimated totals. Also included are tables for the four census regions and the total U.S

These are tables of State estimates for 25 measures of substance use and mental health based on the combined 2010 and 2011 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Results are provided by State by age group.

Tags: mental-health, prevalence-estimates, samhsa, state-level-data, substance-use
Organization: U.S. Department of Health & Human Services
NYTD Technical Bulletin #2: Compliance Standards

This TB describes the standards a NYTD data file must meet to comply with the provisions of the NYTD regulation found at 45 CFR 1356.85, including element-by-element details of the error-free information standards states must meet pursuant to 45 CFR 1356.85(a)(3) and 1356.85(b)(1).

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: compliance, data, policy, reporting, standard
Organization: U.S. Department of Health & Human Services
Compound 528588: Bis[tert-butyl(dimethyl)silyl] oxalate

Chemical compound data from PubChem database. IUPAC Name: bis[tert-butyl(dimethyl)silyl] oxalate. Molecular Formula: C14H30O4Si2. Molecular Weight: 318.56. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Runaway and Homeless Youth Management Information System (1996)

It is estimated that over a million young people run away or become homeless each year.  These youth face increasingly complex issues, including substance abuse, physical and sexual abuse, and AIDS.  The serious issues faced by these youths are coupled with funding constraints among almost all agencies providing services to this population.  In 1974 the Family and Youth Services Bureau (FYSB) authorized funding to assist community based programs to serve youth who were not otherwise being served by traditional human service agencies.  The funding was used for the operation of basic center programs which would provide support for runaway and homeless youth (RHY).  The programs offered emergency shelter, crisis intervention services, and family reunification services.   In 1988 the Transitional Living Program was introduced in order to provide services to older youth requiring assistance in becoming self-sufficient.While helping to support at-risk youth, the FYSB laws also mandate that certain data be regularly collected and reported.  For example, FYSB supported agencies must report on the profile of the youth and families they serve, and provide an overview of the services which they deliver under their grant programs.  In order to assist these grantees in their reporting responsibilities, FYSB funded the development of a Runaway and Homeless Youth Management Information System (RHY MIS).  The RHY MIS was designed to provide comprehensive information on youth served, services provided, and programs which provide the services.The RHY MIS was designed, developed, and implemented by Information Technology International (ITI).  Gradual implementation of the MIS began in 1992 with approximately 400 RHY grantee sites across the country.  By 1995, virtually all existing grant programs had at least one staff member who had been trained and grantees were expected to use the MIS and submit data to FYSB on a quarterly basis.The fiscal year 1996 RHY MIS dataset contains data submitted during the federal fiscal year 1996.  Data are included from participating agencies in 53 US States and Territories.  The dataset includes three files. A demographics file contains 72540 observations and 153 variables. Two additional files contain 64100 observations and a combined 235 variables pertaining to youth problems and services provided.

Investigators: Papadopoulos, Helen & Diepenbrock, Elaine

Tags: abuse, care, ndacan, policy, reporting
Organization: U.S. Department of Health & Human Services
Report to Congress on Immunity from Prosecution for Mandated Reporters

This report to Congress provides an overview of information collected from professionals in the field affected by immunity issues related to the response and investigation of child maltreatment and also summarizes state statutes on immunity.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: child, legal, maltreatment, policy, reporting
Organization: U.S. Department of Health & Human Services