AndreaBozzo/ceres-open-data-index huggingface dataset:
Embryonic stem cells and mice expressing different GFP variants for multiple non-invasive reporter usage within a single animal

Background
          Non-invasive autofluorescent reporters have revolutionized lineage labeling in an array of different organisms. In recent years green fluorescent protein (GFP) from the bioluminescent jellyfish Aequoria Victoria has gained popularity in mouse transgenic and gene targeting regimes [1]. It offers several advantages over conventional gene-based reporters, such as lacZ and alkaline phosphatase, in that its visualization does not require a chromogenic substrate and can be realized in vivo. We have previously demonstrated the utility and developmental neutrality of enhanced green fluorescent protein (EGFP) in embryonic stem (ES) cells and mice [2].
        
        
          Results
          In this study we have used embryonic stem (ES) cell-mediated transgenesis to test the enhanced cyan fluorescent protein (ECFP) and enhanced yellow fluorescent protein (EYFP), two mutant and spectrally distinct color variants of wild type (wt) GFP. We have also tested DsRed1, the novel red fluorescent protein reporter recently cloned from the Discostoma coral by virtue of its homology to GFP. To this end, we have established lines of ES cells together with viable and fertile mice having widespread expression of either the ECFP or EYFP GFP-variant reporters. However, we were unable to generate equivalent DsRed1 lines, suggesting that DsRed1 is not developmentally neutral or that transgene expression cannot be sustained constitutively. Balanced (diploid <-> diploid) and polarized (tetraploid <-> diploid) chimeras comprising combinations of the ECFP and EYFP ES cells and/or embryos, demonstrate that populations of cells expressing each individual reporter can be distinguished within a single animal.
        
        
          Conclusions
          GFP variant reporters are unique in allowing non-invasive multi-spectral visualization in live samples. The ECFP and EYFP-expressing transgenic ES cells and mice that we have generated provide sources of cells and tissues for combinatorial, double-tagged recombination experiments, chimeras or transplantations.

Tags: embryonic-stem-cells, fluorescent-proteins, gfp-variants, nih, transgenic-mice
Organization: U.S. Department of Health & Human Services
Compound 529101: 8-Methyl-4H-pyrido[1,2-a]pyrimidin-4-one

Chemical compound data from PubChem database. IUPAC Name: 8-methylpyrido[1,2-a]pyrimidin-4-one. Molecular Formula: C9H8N2O. Molecular Weight: 160.17. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Annual Report to Congress on State Child Welfare Expenditures Reported on the CFS-101 (2022)

This report to Congress provides national totals of planned spending by service category for the Stephanie Tubbs Jones Child Welfare Services program and planned and actual spending by service category for the Promoting Safe and Stable Families program.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: child, data, policy, reporting, scope
Organization: U.S. Department of Health & Human Services
Compound 526934: 2-Furylmethyl 3-thienyl disulphide

Chemical compound data from PubChem database. IUPAC Name: 2-[(thiophen-3-yldisulfanyl)methyl]furan. Molecular Formula: C9H8OS3. Molecular Weight: 228.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Adenosine preconditioning attenuates hepatic reperfusion injury in the rat by preventing the down-regulation of endothelial nitric oxide synthase

Background
          Previous work has suggested that in the liver, adenosine preconditioning is mediated by nitric oxide. Whether the endothelial isoform of nitric oxide synthase plays a part in this mechanism has however not yet been investigated.
        
        
          Methods
          Wistar rats were used (6 in each group) – Groups: (1) sham, (2) ischemia-reperfusion, (3) adenosine + ischemia-reperfusion, (4) endothelial isoform inhibitor + adenosine + ischemia-reperfusion.
        
        
          Results
          Using immunohistochemistry, this study has revealed a decrease in the expression of endothelial nitric oxide synthase following hepatic ischemia-reperfusion. This was prevented by adenosine pre-treatment. When an inhibitor of endothelial nitric oxide synthase was administered prior to adenosine pre-treatment, pre-conditioning did not occur despite normal expression of endothelial nitric oxide synthase.
        
        
          Conclusions
          These findings suggest that adenosine attenuates hepatic injury by preventing the downregulation of endothelial nitric oxide synthase that occurs during ischemia-reperfusion.

Tags: adenosine-preconditioning, hepatic-ischemia-reperfusion, liver-injury, nih, nitric-oxide-synthase
Organization: U.S. Department of Health & Human Services
ROCKWOOL-Duke Comparative Indigenous Child Welfare Contact Database

The ROCKWOOL-Duke Comparative Indigenous Child Welfare Contact dataset compiles cross-national aggregate information about child welfare contact of indigenous (or native, aboriginal) children compared to non-indigenous children, between 2010 and 2023, from 3 countries who have a history of colonial rule: Denmark, Greenland (Kalaallit Nunaat), and the United States. This dataset is a new and unique resource for comparative and longitudinal research of how indigenous children’s child welfare outcomes differ to those of non-indigenous children. 
Data were collected from national child welfare or national statistical agencies, and measures include notifications of child maltreatment, investigations of maltreatment, confirmed cases of maltreatment, placements in out-of-home care, and the number of children in out-of-home care. Population data are also included for the measurement of incidence and prevalence of system contact. It is important to note that child welfare definitions and the administration of child welfare and protective service vary between countries and caution is warranted in the interpretation of variation and change in system contact. Users should read the User’s Guide carefully before using the data.

Investigators: Mikkeline Nielsen, M.Sc., ROCKWOOL Foundation
Alexander F. Roehrkasse, Ph.D., Butler University
Peter Fallesen, Ph.D., Stockholm University and the ROCKWOOL Foundation
Martin Eiermann, Ph.D., Duke University
Christopher Wildeman, Ph.D., Duke University and the ROCKWOOL Foundation
Sarah Sernaker, M.Sc., Duke University
Alexandra Gibbons, Duke University

Tags: abuse, care, ndacan, policy, reporting
Organization: U.S. Department of Health & Human Services
Compound 530438: 4-Ethylbenzoic acid, 1-adamantylmethyl ester

Chemical compound data from PubChem database. IUPAC Name: 1-adamantylmethyl 4-ethylbenzoate. Molecular Formula: C20H26O2. Molecular Weight: 298.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Estrogen receptor alpha dinucleotide repeat polymorphism in Japanese patients with autoimmune thyroid diseases

Background
          The autoimmune thyroid diseases (AITDs), comprising Graves' disease (GD) and Hashimoto's thyroiditis (HT), appear to develop as a result of complex interactions between predisposing genes and environmental triggers. Susceptibility to AITDs is conferred by genes in the human leukocyte antigen (HLA) and genes unlinked to HLA, including the CTLA-4 gene. Recently, an association to some estrogen receptor (ER)α genotypes with breast cancer, hypertension, osteoporosis, generalized osteoarthritis, and some autoimmune diseases such as rheumatoid arthritis has been reported. We have analyzed a dinucleotide (TA)n repeat polymorphism lying upstream of the human ERα gene in patients with AITDs and in normal subjects.
        
        
          Results
          Seventeen different alleles were found in 130 patients with GD, 93 patients with HT, and 190 control subjects. There was no significant difference in the distributions of ERα alleles between patients and controls.
        
        
          Conclusions
          The present results do not support an association between the ERα gene and AITD in the Japanese population.

Tags: autoimmune-thyroid, estrogen-receptor, graves-disease, hashimoto-thyroiditis, nih
Organization: U.S. Department of Health & Human Services
Compound 530209: Benzeneacetic acid, 3-methoxy-alpha-[(trimethylsilyl)oxy]-, trimethylsilyl ester

Chemical compound data from PubChem database. IUPAC Name: trimethylsilyl 2-(3-methoxyphenyl)-2-trimethylsilyloxyacetate. Molecular Formula: C15H26O4Si2. Molecular Weight: 326.53. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 529820: Octanal, 2,4,6-trichlorophenyl hydrazone

Chemical compound data from PubChem database. IUPAC Name: 2,4,6-trichloro-N-(octylideneamino)aniline. Molecular Formula: C14H19Cl3N2. Molecular Weight: 321.7. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 526737: 2-(2-nonyloxy-ethoxy)-ethanol, TFA

Chemical compound data from PubChem database. IUPAC Name: 2-(2-nonoxyethoxy)ethyl 2,2,2-trifluoroacetate. Molecular Formula: C15H27F3O4. Molecular Weight: 328.37. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Analysis of prolactin-modulated gene expression profiles during the Nb2 cell cycle using differential screening techniques

Background:
          Rat Nb2-11C lymphoma cells are dependent on prolactin for proliferation and are widely used to study prolactin signaling pathways. To investigate the role of this hormone in the transcriptional mechanisms that underlie prolactin-stimulated mitogenesis, five different techniques were used to isolate differentially expressed transcripts: mRNA differential display, representational difference analysis (RDA), subtractive suppressive hybridization (SSH), analysis of weakly expressed candidate genes, and differential screening of an organized library.
        
        
          Results:
          About 70 transcripts were found to be modulated in Nb2 cells following prolactin treatment. Of these, approximately 20 represent unknown genes. All cDNAs were characterized by northern blot analysis and categorized on the basis of their expression profiles and the functions of the known genes. We compared our data with other cell-cycle-regulated transcripts and found several new potential signaling molecules that may be involved in Nb2 cell growth. In addition, abnormalities in the expression patterns of several transcripts were detected in Nb2 cells, including the constitutive expression of the immediate-early gene EGR-1. Finally, we compared the differential screening techniques in terms of sensitivity, efficiency and occurrence of false positives.
        
        
          Conclusions:
          Using these techniques to determine which genes are differentially expressed in Nb2 lymphoma cells, we have obtained valuable insight into the potential functions of some of these genes in the cell cycle. Although this information is preliminary, comparison with other eukaryotic models of cell-cycle progression enables identification of expression abnormalities and proteins potentially involved in signal transduction, which could indicate new directions for research.

Tags: cell-cycle-regulation, gene-expression-profiles, nb2-lymphoma-cells, nih, prolactin-signaling
Organization: U.S. Department of Health & Human Services
Compound 525884: N,N-Dimethyl-N'-(4-chlorophenyl)-isobutyramidine

Chemical compound data from PubChem database. IUPAC Name: N'-(4-chlorophenyl)-N,N,2-trimethylpropanimidamide. Molecular Formula: C12H17ClN2. Molecular Weight: 224.73. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 529882: 2-(2-Furyl)-5(6)-acetylpyrazine

Chemical compound data from PubChem database. IUPAC Name: 1-[5-(furan-2-yl)pyrazin-2-yl]ethanone. Molecular Formula: C10H8N2O2. Molecular Weight: 188.18. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 529080: bis-[3,3-(2-Methylpropanol-1)] disulfide

Chemical compound data from PubChem database. IUPAC Name: 3-[(3-hydroxy-2-methylpropyl)disulfanyl]-2-methylpropan-1-ol. Molecular Formula: C8H18O2S2. Molecular Weight: 210.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 525269: N'-(3-fluoro-phenyl)-N,N-dimethyl-acetamidine

Chemical compound data from PubChem database. IUPAC Name: N'-(3-fluorophenyl)-N,N-dimethylethanimidamide. Molecular Formula: C10H13FN2. Molecular Weight: 180.22. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 525777: 4-Butyl-2,5-dimethyloxazole

Chemical compound data from PubChem database. IUPAC Name: 4-butyl-2,5-dimethyl-1,3-oxazole. Molecular Formula: C9H15NO. Molecular Weight: 153.22. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 527982: Pentanoic acid, 4-methyl-, 2-chloro-1-(chloromethyl)ethyl ester

Chemical compound data from PubChem database. IUPAC Name: 1,3-dichloropropan-2-yl 4-methylpentanoate. Molecular Formula: C9H16Cl2O2. Molecular Weight: 227.12. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Re-HEDP : pharmacokinetic characterization, clinical and dosimetric evaluation in osseous metastatic patients with two levels of radiopharmaceutical dose

Background
          A study for pain relief therapy with 188Re-HEDP was done in patients with bone metastases secondary to breast and prostate cancer.
        
        
          Materials and Methods
          Patients received 1.3 or 2.2 GBq, in single or multiple doses. Platelets, white and red cells were evaluated during 11 weeks. Pharmacokinetic characterization was done from blood and urine samples for 5 patients along 24 hours. Urinary excretion was evaluated in other 16 patients during 6 hours. Bone uptake was estimated as remaining activity in whole body. Scintigraphic images were acquired at 2 and 24 hs post-administration. Absorbed dose in bone marrow was estimated with Mirdose3. Analgesics intake and pain score were daily recorded. Tumour markers (PSA, and Tn-structure) were monitored in 9 patients during 4 to 6 months. Single doses of low activity (1.3 GBq) were given to twelve patients. Nine patients received multiple doses.
        
        
          Results
          All except one patient had normal levels of platelets, white and red cells. Remaining dose in blood at 2 hours was 9%. Urinary elimination was 58%. Bone uptake at 24 hours was 43% (mean value; n = 5). No changes of the haematological parameters were detected along follow-up period. Pain relief was evidenced by decrease or supression of opioid analgesic and by subjective index. PSA showed a decrease in prostate cancer patients (n = 4). Tn-structure showed a significant increase after 4 to 8 months.
        
        
          Conclusion
          Single or multiple dose scheme could be safely used, with administered activity of 188Re-HEDP up to 60 mCi, with low bone marrow absorbed doses.

Tags: bone-metastases, nih, pain-relief, radiopharmaceutical-therapy, re-hedp
Organization: U.S. Department of Health & Human Services
Compound 526758: 11-Hexyl-oxacycloundecan-2-one

Chemical compound data from PubChem database. IUPAC Name: 11-hexyl-oxacycloundecan-2-one. Molecular Formula: C16H30O2. Molecular Weight: 254.41. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Mississippi 2016 Potential Areas for Addressing Service Gaps for Opioid Treatment

The purpose of the medication-assisted treatment (MAT) facility maps is to identify areas on a state-by-state basis that may be potentially underserved by existing treatment facilities. The maps are created with a methodology that seeks to include the highest potential need areas from individual counties so that county-level stakeholders are also informed. The maps are meant to be used as a tool for policy makers to determine potentially underserved areas—not as a definitive representation of these areas.

Tags: medication-assisted-treatment, mississippi, opioid-treatment, samhsa, service-gap-analysis
Organization: U.S. Department of Health & Human Services
Compound 525734: Butyltriethoxysilane

Chemical compound data from PubChem database. IUPAC Name: butyl(triethoxy)silane. Molecular Formula: C10H24O3Si. Molecular Weight: 220.38. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2012 Uniform Reporting System (URS) Tables for Indiana

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2012. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, outcome-measures, samhsa, urs-data
Organization: U.S. Department of Health & Human Services
2020 Uniform Reporting System (URS) Table For Vermont

This is the 2020 Uniform Reporting System (URS) Output Tables for Vermont. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-program, mental-health-services, national-outcome-measures, samhsa, vermont
Organization: U.S. Department of Health & Human Services
Time between Termination of Parental Rights (TPR) and Adoption Finalization: 10/1/2009 - 9/30/2010

This report provides state-specific data from fiscal year 2010 about the time between the termination of parental rights and the adoption finalization for public agency adoptions.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: adoption, child, data, fiscal, policy
Organization: U.S. Department of Health & Human Services
Compound 529988: Ethyl 7-chloroheptanoate

Chemical compound data from PubChem database. IUPAC Name: ethyl 7-chloroheptanoate. Molecular Formula: C9H17ClO2. Molecular Weight: 192.68. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Patent AT-E399653-T1: [Translated] DEVICE FOR FILLING SHEETS INTO AN ENVELOPE

The invention relates to a device for inserting sheets into an envelope, comprising a holding device (11) for holding the envelope, transport means (15) for feeding the sheets to be inserted to the holding device (11), a feed device (7, 8, 9) for feeding the envelope to the holding device (11), along a feed direction, and a removal device (8, 22) for removing the filled envelope from the holding device (11), along a removal direction. The invention is characterized in that the feed device (7, 8, 9) and the removal device (8, 22) are disposed relative to the holding device (11) in such a manner that a first angle between the feed device and a main surface of the holding device (11) and a second angle between the removal direction and the main surface of the holding device (11) are predetermined in a fixed manner and are different from each other. The invention allows to simplify the construction of the device, thereby reducing its technical complexity and failure proneness. The elimination of a swiveling movement results in a gain in time, thereby increasing the capacity of the device.

Tags: chemistry, innovation, patent, pubchem, research
Organization: U.S. Department of Health & Human Services
Compound 525114: 3-Chloropropyl decanoate

Chemical compound data from PubChem database. IUPAC Name: 3-chloropropyl decanoate. Molecular Formula: C13H25ClO2. Molecular Weight: 248.79. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services