AndreaBozzo/ceres-open-data-index huggingface dataset:
Development of an In Vitro Human Thyroid Microtissue Model for Chemical Screening

The objective of this study was to develop a medium-throughput organotypic screening assay comprised of reconstructed human thyroid microtissues to quantitatively evaluate the disruptive effects of chemicals on TH production and secretion. Primary human thyroid cells procured from qualified euthyroid donors were analyzed for retention of NK2 homeobox 1 (NKX2-1), Keratin 7 (KRT7), and Thyroglobulin (TG) expression by high-content image analysis to verify enrichment of follicular epithelial cells. A direct comparison of two-dimensional (2D) and three-dimensional (3D) 96-well culture formats
was employed to characterize the morphology, differential gene expression, TG production, and TH synthesis over the course of 20 days. 

This dataset is associated with the following publication:
Deisenroth, C., V. Soldatow, J. Ford, W. Stewart, C. Brinkman, E. LeCluyse, D. Macmillan, and R. Thomas. Development of an In Vitro Human Thyroid Microtissue Model for Chemical Screening (ToxSci).   TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA,  174(1): 63-78, (2020).

Tags: endocrine-toxicology, organotypic-culture-model, thyroid, thyroid-disrupting-chemicals, tipping-points, vembryo, virtual-embryo, virtual-tissues
Organization: U.S. Environmental Protection Agency
Commission Adequacy Determinations

The Commission’s notice of institution in five-year reviews requests that interested parties file with the Commission responses that discuss the likely effects of revoking the order under review and provide other pertinent information. Generally within 95 days from institution, the Commission will determine whether the responses it has received reflect an adequate or inadequate level of interest in a full review.

Tags: adequacy, countervailing-duty, determinations, international-trade
Organization: US International Trade Commission
Harmonized Tariff Schedule (HTS) Archive

Editions of the Harmonized Tariff Schedule of the United States Annotated (HTSA) are available from 1989 (the first year of publication) - present. Select editions are available in HTML format. Some editions are also available as CSV, XLS, or JSON file downloads.

Tags: adequacy, countervailing-duty, determinations, international-trade
Organization: US International Trade Commission
HHS Provider Relief Fund

<p>President Trump is providing support to healthcare providers fighting the coronavirus disease 2019 (COVID-19) pandemic through the bipartisan Coronavirus Aid, Relief, &amp; Economic Security Act and the Paycheck Protection Program and Health Care Enhancement Act, which provide a total of $175 billion for relief funds to hospitals and other healthcare providers on the front lines of the COVID-19 response. This funding supports healthcare-related expenses or lost revenue attributable to COVID-19 and ensures uninsured Americans can get treatment for COVID-19. HHS is distributing this Provider Relief Fund (PRF) money and these payments do not need to be repaid.</p>
<p>The Department allocated $50 billion in PRF payments for general distribution to Medicare facilities and providers impacted by COVID-19, based on eligible providers' net reimbursement. HHS has made other PRF distributions to a wide array of health care providers and more information on those distributions can be found here: <a href="https://www.hhs.gov/coronavirus/cares-act-provider-relief-fund/data/index.html">https://www.hhs.gov/coronavirus/cares-act-provider-relief-fund/data/inde...</a></p>


Tags: cares-act, health-system, provider-relief-fund
Organization: U.S. Department of Health & Human Services
2015 Cartographic Boundary File, United States, 1:20,000,000

The 2015 cartographic boundary KMLs are simplified representations of selected geographic areas from the U.S. Census Bureau's Master
                                 Address File / Topologically Integrated Geographic Encoding and Referencing (MAF/TIGER) Database (MTDB). These boundary files are
                                 specifically designed for small-scale thematic mapping. When possible, generalization is performed with the intent to maintain the
                                 hierarchical relationships among geographies and to maintain the alignment of geographies within a file set for a given year.
                                 Geographic areas may not align with the same areas from another year. Some geographies are available as nation-based files while others
                                 are available only as state-based files.

                                 This file depicts the shape of the United States clipped back to a generalized coastline.  This nation layer covers the extent of the
                                 fifty states, the District of Columbia, Puerto Rico, and each of the Island Areas (American Samoa, the Commonwealth of the Northern
                                 Mariana Islands, Guam, and the U.S. Virgin Islands) when scale appropriate.
            

Tags: 2015, boundaries, cartographic boundary, generalized, kml, united states, us
Organization: U.S. Census Bureau, Department of Commerce
Series Information File for the 2015 Cartographic Boundary File,  State-PUMA , 1:500,000

The 2015 cartographic boundary KMLs are simplified representations of selected geographic areas from the U.S. Census Bureau's Master
                                 Address File / Topologically Integrated Geographic Encoding and Referencing (MAF/TIGER) Database (MTDB). These boundary files are
                                 specifically designed for small-scale thematic mapping. When possible, generalization is performed with the intent to maintain the
                                 hierarchical relationships among geographies and to maintain the alignment of geographies within a file set for a given year.
                                 Geographic areas may not align with the same areas from another year. Some geographies are available as nation-based files while others
                                 are available only as state-based files.

                                 After each decennial census, the Census Bureau delineates Public Use Microdata Areas (PUMAs) for the tabulation and dissemination of
                                 decennial census Public Use Microdata Sample (PUMS) data, American Community Survey (ACS) PUMS data, and ACS period estimates. Nesting
                                 within states, or equivalent entities, PUMAs cover the entirety of the United States, Puerto Rico, Guam, and the U.S. Virgin Islands.
                                 PUMA delineations are subject to population, building block geography, geographic nesting, and contiguity criteria. Each PUMA is
                                 identified by a 5-character numeric census code that may contain leading zeros and a descriptive name.
            

Tags: 2015, boundaries, cartographic boundary, generalized, kml, public use microdata area, state, state or equivalent entity, u.s., united states
Organization: U.S. Census Bureau, Department of Commerce
2015 Cartographic Boundary File, Region for United States, 1:20,000,000

The 2015 cartographic boundary KMLs are simplified representations of selected geographic areas from the U.S. Census Bureau's Master
                                 Address File / Topologically Integrated Geographic Encoding and Referencing (MAF/TIGER) Database (MTDB). These boundary files are
                                 specifically designed for small-scale thematic mapping. When possible, generalization is performed with the intent to maintain the
                                 hierarchical relationships among geographies and to maintain the alignment of geographies within a file set for a given year.
                                 Geographic areas may not align with the same areas from another year. Some geographies are available as nation-based files while others
                                 are available only as state-based files.

                                 Regions are four groupings of States (Northeast, South, Midwest, and West) established by the Census Bureau in 1942 for the
                                 presentation of census data.
            

Tags: 2015, boundaries, cartographic boundary, generalized, kml, region, united states, us
Organization: U.S. Census Bureau, Department of Commerce
Series Information File for the 2015 Cartographic Boundary File, State-Place, 1:500,000

The 2015 cartographic boundary KMLs are simplified representations of selected geographic areas from the U.S. Census Bureau's Master
                                 Address File / Topologically Integrated Geographic Encoding and Referencing (MAF/TIGER) Database (MTDB). These boundary files are
                                 specifically designed for small-scale thematic mapping. When possible, generalization is performed with the intent to maintain the
                                 hierarchical relationships among geographies and to maintain the alignment of geographies within a file set for a given year.
                                 Geographic areas may not align with the same areas from another year. Some geographies are available as nation-based files while others
                                 are available only as state-based files.

                                 The cartographic boundary files include both incorporated places (legal entities) and census designated places or CDPs (statistical
                                 entities).  An incorporated place is established to provide governmental functions for a concentration of people as opposed to a minor
                                 civil division (MCD), which generally is created to provide services or administer an area without regard, necessarily, to population.
                                 Places always nest within a state, but may extend across county and county subdivision boundaries.  An incorporated place usually is a
                                 city, town, village, or borough, but can have other legal descriptions.  CDPs are delineated for the decennial census as the
                                 statistical counterparts of incorporated places.  CDPs are delineated to provide data for settled concentrations of population that are
                                 identifiable by name, but are not legally incorporated under the laws of the state in which they are located.  The boundaries for CDPs
                                 often are defined in partnership with state, local, and/or tribal officials and usually coincide with visible features or the boundary
                                 of an adjacent incorporated place or another legal entity.  CDP boundaries often change from one decennial census to the next with
                                 changes in the settlement pattern and development; a CDP with the same name as in an earlier census does not necessarily have the same
                                 boundary.  The only population/housing size requirement for CDPs is that they must contain some housing and population.
            

Tags: 2015, boundaries, cartographic boundary, generalized, kml, place, state, state or equivalent entity, u.s., united states
Organization: U.S. Census Bureau, Department of Commerce
2015 Cartographic Boundary File, Division for United States, 1:5,000,000

The 2015 cartographic boundary KMLs are simplified representations of selected geographic areas from the U.S. Census Bureau's Master
                                 Address File / Topologically Integrated Geographic Encoding and Referencing (MAF/TIGER) Database (MTDB). These boundary files are
                                 specifically designed for small-scale thematic mapping. When possible, generalization is performed with the intent to maintain the
                                 hierarchical relationships among geographies and to maintain the alignment of geographies within a file set for a given year.
                                 Geographic areas may not align with the same areas from another year. Some geographies are available as nation-based files while others
                                 are available only as state-based files.

                                 Divisions are groupings of states within a census geographic region, established by the Census Bureau for the presentation of census
                                 data. The current nine divisions (East North Central, East South Central, Middle Atlantic, Mountain, New England, Pacific, South
                                 Atlantic, West North Central, and West South Central) are intended to represent relatively homogeneous areas that are subdivisions of
                                 the four census geographic regions.

Tags: 2015, boundaries, cartographic boundary, division, generalized, kml, united states, us
Organization: U.S. Census Bureau, Department of Commerce
2015 Cartographic Boundary File, New England City and Town Area for United States, 1:500,000

The 2015 cartographic boundary KMLs are simplified representations of selected geographic areas from the U.S. Census Bureau's Master
                                 Address File / Topologically Integrated Geographic Encoding and Referencing (MAF/TIGER) Database (MTDB). These boundary files are
                                 specifically designed for small-scale thematic mapping. When possible, generalization is performed with the intent to maintain the
                                 hierarchical relationships among geographies and to maintain the alignment of geographies within a file set for a given year.
                                 Geographic areas may not align with the same areas from another year. Some geographies are available as nation-based files while others
                                 are available only as state-based files.

                                 In New England (Connecticut, Maine, Massachusetts, New Hampshire, Rhode Island, and Vermont), the Office of Management and Budget (OMB)
                                 has defined an alternative county subdivision (generally cities and towns) based definition of Core Based Statistical Areas (CBSAs)
                                 known as New England City and Town Areas (NECTAs).  NECTAs are defined using the same criteria as Metropolitan Statistical Areas and
                                 Micropolitan Statistical Areas and are identified as either metropolitan or micropolitan, based, respectively, on the presence of
                                 either an urban area of 50,000 or more population or an urban cluster of at least 10,000 and less than 50,000 population. A NECTA
                                 containing a single core urban area with a population of at least 2.5 million may be subdivided to form smaller groupings of cities and
                                 towns referred to as NECTA Divisions.

                                 The generalized NECTA boundaries in this file are based on those defined by OMB based on the 2010 Census and published in 2013.
            

Tags: 2015, boundaries, cartographic boundary, generalized, kml, necta, new england city and town area, united states, us
Organization: U.S. Census Bureau, Department of Commerce
2015 Cartographic Boundary File, Division for United States, 1:20,000,000

The 2015 cartographic boundary KMLs are simplified representations of selected geographic areas from the U.S. Census Bureau's Master
                                 Address File / Topologically Integrated Geographic Encoding and Referencing (MAF/TIGER) Database (MTDB). These boundary files are
                                 specifically designed for small-scale thematic mapping. When possible, generalization is performed with the intent to maintain the
                                 hierarchical relationships among geographies and to maintain the alignment of geographies within a file set for a given year.
                                 Geographic areas may not align with the same areas from another year. Some geographies are available as nation-based files while others
                                 are available only as state-based files.

                                 Divisions are groupings of states within a census geographic region, established by the Census Bureau for the presentation of census
                                 data. The current nine divisions (East North Central, East South Central, Middle Atlantic, Mountain, New England, Pacific, South
                                 Atlantic, West North Central, and West South Central) are intended to represent relatively homogeneous areas that are subdivisions of
                                 the four census geographic regions.
            

Tags: 2015, boundaries, cartographic boundary, division, generalized, kml, united states, us
Organization: U.S. Census Bureau, Department of Commerce
2015 Cartographic Boundary File, Combined Statistical Area for United States, 1:5,000,000

The 2015 cartographic boundary KMLs are simplified representations of selected geographic areas from the U.S. Census Bureau's Master
                                 Address File / Topologically Integrated Geographic Encoding and Referencing (MAF/TIGER) Database (MTDB). These boundary files are
                                 specifically designed for small-scale thematic mapping. When possible, generalization is performed with the intent to maintain the
                                 hierarchical relationships among geographies and to maintain the alignment of geographies within a file set for a given year.
                                 Geographic areas may not align with the same areas from another year. Some geographies are available as nation-based files while others
                                 are available only as state-based files.

                                 Combined Statistical Areas (CSAs) are defined by the Office of Management and Budget (OMB) and consist of two or more adjacent Core
                                 Based Statistical Areas (CBSAs) that have significant employment interchanges.  The CBSAs that combine to create a CSA retain separate
                                 identities within the larger CSA.  Because CSAs represent groupings of CBSAs, they should not be ranked or compared with individual
                                 CBSAs.
            

Tags: 2015, boundaries, cartographic boundary, combined statistical area, generalized, kml, united states, us
Organization: U.S. Census Bureau, Department of Commerce
2015 Cartographic Boundary File, United States, 1:5,000,000

The 2015 cartographic boundary KMLs are simplified representations of selected geographic areas from the U.S. Census Bureau's Master
                                 Address File / Topologically Integrated Geographic Encoding and Referencing (MAF/TIGER) Database (MTDB). These boundary files are
                                 specifically designed for small-scale thematic mapping. When possible, generalization is performed with the intent to maintain the
                                 hierarchical relationships among geographies and to maintain the alignment of geographies within a file set for a given year.
                                 Geographic areas may not align with the same areas from another year. Some geographies are available as nation-based files while others
                                 are available only as state-based files.

                                 This file depicts the shape of the United States clipped back to a generalized coastline.  This nation layer covers the extent of the
                                 fifty states, the District of Columbia, Puerto Rico, and each of the Island Areas (American Samoa, the Commonwealth of the Northern
                                 Mariana Islands, Guam, and the U.S. Virgin Islands) when scale appropriate.
            

Tags: 2015, boundaries, cartographic boundary, generalized, kml, united states, us
Organization: U.S. Census Bureau, Department of Commerce
2015 Cartographic Boundary File, Combined Statistical Area for United States, 1:500,000

The 2015 cartographic boundary KMLs are simplified representations of selected geographic areas from the U.S. Census Bureau's Master
                                 Address File / Topologically Integrated Geographic Encoding and Referencing (MAF/TIGER) Database (MTDB). These boundary files are
                                 specifically designed for small-scale thematic mapping. When possible, generalization is performed with the intent to maintain the
                                 hierarchical relationships among geographies and to maintain the alignment of geographies within a file set for a given year.
                                 Geographic areas may not align with the same areas from another year. Some geographies are available as nation-based files while others
                                 are available only as state-based files.

                                 Combined Statistical Areas (CSAs) are defined by the Office of Management and Budget (OMB) and consist of two or more adjacent Core
                                 Based Statistical Areas (CBSAs) that have significant employment interchanges.  The CBSAs that combine to create a CSA retain separate
                                 identities within the larger CSA.  Because CSAs represent groupings of CBSAs, they should not be ranked or compared with individual
                                 CBSAs.
            

Tags: 2015, boundaries, cartographic boundary, combined statistical area, generalized, kml, united states, us
Organization: U.S. Census Bureau, Department of Commerce
2015 Cartographic Boundary File, Division for United States, 1:500,000

The 2015 cartographic boundary KMLs are simplified representations of selected geographic areas from the U.S. Census Bureau's Master
                                 Address File / Topologically Integrated Geographic Encoding and Referencing (MAF/TIGER) Database (MTDB). These boundary files are
                                 specifically designed for small-scale thematic mapping. When possible, generalization is performed with the intent to maintain the
                                 hierarchical relationships among geographies and to maintain the alignment of geographies within a file set for a given year.
                                 Geographic areas may not align with the same areas from another year. Some geographies are available as nation-based files while others
                                 are available only as state-based files.

                                 Divisions are groupings of states within a census geographic region, established by the Census Bureau for the presentation of census
                                 data. The current nine divisions (East North Central, East South Central, Middle Atlantic, Mountain, New England, Pacific, South
                                 Atlantic, West North Central, and West South Central) are intended to represent relatively homogeneous areas that are subdivisions of
                                 the four census geographic regions.
            

Tags: 2015, boundaries, cartographic boundary, division, generalized, kml, united states, us
Organization: U.S. Census Bureau, Department of Commerce