AndreaBozzo/ceres-open-data-index huggingface dataset:
Expression and localization of estrogen receptor-β in annulus cells of the human intervertebral disc and the mitogenic effect of 17-β-estradiol in vitro

Background
          Recent evidence suggests that estrogens exert effects in different tissues throughout the body, and that the estrogen receptor β (ERβ) may be important for the action of estrogen (17-β-estradiol) on the skeleton. The cellular localization of ERβ in the human intervertebral disc, however, has not yet been explored.
        
        
          Methods
          Human disc tissue and cultured human disc cells were used for immunocytochemical localization of ERβ. mRNA was isolated from cultured human disc cells, and RT-PCR amplification of ERβ was employed to document molecular expression of this receptor. Cultured human disc cells were tested to determine if 17-β-estradiol stimulated cell proliferation.
        
        
          Results
          In this report data are presented which provide evidence for ERβ gene expression in human intervertebral disc cells in vivo and in vitro. Culture of annulus cells in the presence of 10-7 M 17-β-estradiol significantly increased cell proliferation.
        
        
          Conclusions
          These data provide new insight into the biology of cells in the annulus of the intervertebral disc.

Tags: 17-beta-estradiol, annulus-cells, estrogen-receptor-beta, intervertebral-disc, nih
Organization: U.S. Department of Health & Human Services
Potential antimutagenic activity of berberine, a constituent of

Background
          As part of a study aimed at developing new pharmaceutical products from natural resources, the purpose of this research was twofold: (1) to fractionate crude extracts from the bark of Mahonia aquifolium and (2) to evaluate the strength of the antimutagenic activity of the separate components against one of the common direct-acting chemical mutagens.
        
        
          Methods
          The antimutagenic potency was evaluated against acridine orange (AO) by using Euglena gracilis as an eukaryotic test model, based on the ability of the test compound/fraction to prevent the mutagen-induced damage of chloroplast DNA.
        
        
          Results
          It was found that the antimutagenicity of the crude Mahonia extract resides in both bis-benzylisoquinoline (BBI) and protoberberine alkaloid fractions but only the protoberberine derivatives, jatrorrhizine and berberine, showed significant concentration-dependent inhibitory effect against the AO-induced chloroplast mutagenesis of E. gracilis. Especially berberine elicited, at a very low dose, remarkable suppression of the AO-induced mutagenicity, its antimutagenic potency being almost three orders of magnitude higher when compared to its close analogue, jatrorrhizine. Possible mechanisms of the antimutagenic action are discussed in terms of recent literature data. While the potent antimutagenic activity of the protoberberines most likely results from the inhibition of DNA topoisomerase I, the actual mechanism(s) for the BBI alkaloids is hard to be identified.
        
        
          Conclusions
          Taken together, the results indicate that berberine possesses promising antimutagenic/anticarcinogenic potential that is worth to be investigated further.

Tags: acridine-orange, antimutagenic-activity, berberine, euglena-gracilis, nih
Organization: U.S. Department of Health & Human Services
District of Columbia 2016 Potential Areas for Addressing Service Gaps for Opioid Treatment

The purpose of the medication-assisted treatment (MAT) facility maps is to identify areas on a state-by-state basis that may be potentially underserved by existing treatment facilities. The maps are created with a methodology that seeks to include the highest potential need areas from individual counties so that county-level stakeholders are also informed. The maps are meant to be used as a tool for policy makers to determine potentially underserved areas—not as a definitive representation of these areas.

Tags: dc-opioids, mat-access, opioid-treatment, samhsa, service-gap-analysis
Organization: U.S. Department of Health & Human Services
Compound 525667: p-Bromobenzylidene-cyclohexyl-amine

Chemical compound data from PubChem database. IUPAC Name: 1-(4-bromophenyl)-N-cyclohexylmethanimine. Molecular Formula: C13H16BrN. Molecular Weight: 266.18. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
4.17a Facilities employing specific practices as part of their standard operating procedures, by facility operation and primary focus of facility: 2010. Number

This is a National Survey of Substance Abuse Treatment Services (N-SSATS) data table showing facilities employing specific practices as part of their standard operating procedures, by facility operation and primary focus of facility in 2010. N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 States, the District of Columbia, and other U.S. jurisdictions.

Tags: behavioral-health, facility-practices, n-ssats, samhsa, substance-abuse-treatment
Organization: U.S. Department of Health & Human Services
2010 CMHS Uniform Reporting System (URS) Output Tables for Oregon

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2010. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, national-outcome-measures, oregon, samhsa
Organization: U.S. Department of Health & Human Services
Human Centered Design, User Experience, and Lived Experience CCWIS Toolkit

This technical assistance document provides guidance around the human centered design (HCD) methodology, user experience (UX) methods and outcomes, integrating HCD and UX into Comprehensive Child Welfare Information Systems (CCWIS), incorporating Lived Experience into UX, user research methods, and how to request technical assistance around these concepts.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: instruction, policy, real, time, user
Organization: U.S. Department of Health & Human Services
Evaluating our end-of-life practice

Ferrand et al's recent study of witholding and withdrawing life support in intensive care units in France reminds us that reporting end-of-life practices is an important step towards enhancing end-of-life care. The study highlights differences between the parentalistic approach to decision making in Europe, and the patient autonomy model in the USA. However, the reasons intensivists report for witholding or withdrawing life support are similar in both cultures. Intensivists in France make decisions despite a lack of formal guidelines in their country. This study should serve as a stimulus for educating the public and motivating more groups to monitor their end-of-life practices.

Tags: clinical-decision-making, end-of-life-care, intensive-care, life-support, nih
Organization: U.S. Department of Health & Human Services
The vasculature and its role in the damaged and healing tendon

Tendon pathology has many manifestations, from spontaneous rupture to chronic tendinitis or tendinosis; the etiology and pathology of each are very different, and poorly understood. Tendon is a comparatively poorly vascularised tissue that relies heavily upon synovial fluid diffusion to provide nutrition. During tendon injury, as with damage to any tissue, there is a requirement for cell infiltration from the blood system to provide the necessary reparative factors for tissue healing. We describe in this review the response of the vasculature to tendon damage in a number of forms, and how and when the revascularisation or neovascularisation process occurs. We also include a section on the revascularisation of tendon during its use as a tendon graft in both ligament reconstruction and tendon–tendon grafting.

Tags: nih, tendinopathy, tendon-grafts, tendon-repair, tendon-vascularization
Organization: U.S. Department of Health & Human Services
High calcium and dobutamine positive inotropy in the perfused mouse heart: myofilament calcium responsiveness, energetic economy, and effects of protein kinase C inhibition

Background
          In perfused hearts, high calcium-induced inotropy results in less developed pressure relative to myocardial oxygen consumption compared to the β-adrenergic agonist dobutamine. Calcium handling is an important determinant of myocardial oxygen consumption. Therefore, we hypothesized that this phenomenon was due to reduced myofilament responsiveness to calcium, related to protein kinase C activation.
        
        
          Results
          Developed pressure was significantly higher with dobutamine compared to high perfusate calcium of 3.5 mM (73 ± 10 vs 63 ± 10 mmHg, p < 0.05), though peak systolic intracellular calcium was not significantly different, suggesting reduced myofilament responsiveness to intracellular calcium with high perfusate calcium. The ratio of developed pressure to myocardial oxygen consumption, an index of economy of contraction, was significantly increased with dobutamine compared to high perfusate calcium (1.35 ± 0.15 vs 1.15 ± 0.15 mmHg/μmoles/min/g dry wt, p < 0.05), suggesting energetic inefficiency with high perfusate calcium. The specific protein kinase C inhibitor, chelerythrine, significantly attenuated the expected increase in developed pressure when increasing perfusate calcium from 2.5 to 3.5 mM (3.5 mM: 64 ± 8 vs 3.5 mM + chelerythrine: 55 ± 5 mmHg, p < 0.05), though had no effects on dobutamine, or lower levels of perfusate calcium (1.5 to 2.5 mM).
        
        
          Conclusions
          By measuring intracellular calcium, developed pressures and myocardial oxygen consumption in perfused mouse hearts, these results demonstrate that high perfusate calcium positive inotropy compared to dobutamine results in reduced myofilament responsiveness to intracellular calcium, which is associated with energetic inefficiency and evidence of protein kinase C activation.

Tags: calcium-responsiveness, dobutamine-inotropy, myocardial-oxygen-consumption, nih, perfused-mouse-heart
Organization: U.S. Department of Health & Human Services
2013 CMHS Uniform Reporting System (URS) Tables for Illinois

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Tables for Illinois for 2013. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program.  State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, illinois-mental-health, mental-health-services, samhsa, urs-data
Organization: U.S. Department of Health & Human Services
Seattle: Drug-Related Emergency Department Visits, 2004-2011 - All Misuse and Abuse

Excel file with estimates, rates, relative standard errors, trends and confidence intervals for all drug-related emergency department (ED) visits involving drug misuse or abuse in the Seattle metropolitan area, covering 2004-2011. Drug misuse/abuse visits include the use of illicit drugs, nonmedical use of pharmaceuticals, underage drinking and visits where alcohol was combined with another drug.

Tags: drug-abuse, emergency-department, samhsa, seattle-area, substance-misuse
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Colorado, 2015

This is a behavioral health report for the state of Colorado. The report utilizes data from the National Survey on Drug Use and Health (NSDUH), and the Uniform Reporting System. The topics addressed in the report include youth substance use, youth mental health and treatment, mental health and treatment, substance use and substance use treatment.

Tags: colorado-behavioral-health, mental-health-treatment, nsduh-data, samhsa, youth-substance-use
Organization: U.S. Department of Health & Human Services
Comparative efficacy of two microdoses of a potentized homoeopathic drug, Cadmium Sulphoricum, in reducing genotoxic effects produced by cadmium chloride in mice: a time course study

Background
          Cadmium poisoning in the environment has assumed an alarming problem in recent years. Effective antimutagenic agents which can reverse or combat cadmium induced genotoxicity in mice have not yet been reported. Therefore, in the present study, following the homeopathic principle of "like cures like", we tested the efficacy of two potencies of a homeopathic drug, Cadmium Sulphoricum (Cad Sulph), in reducing the genotoxic effects of Cadmium chloride in mice.
          Another objective was to determine the relative efficacy of three administrative modes, i.e. pre-, post- and combined pre and post-feeding of the homeopathic drugs. For this, healthy mice, Mus musculus, were intraperitoneally injected with 0.008% solution of CdCl2 @ 1 ml/100 gm of body wt (i.e. 0.8 mcg/gm of bw), and assessed for the genotoxic effects through such studies as chromosome aberrations (CA), micronucleated erythrocytes (MNE), mitotic index (MI) and sperm head anomaly (SHA), keeping suitable succussed alcohol fed (positive) and CdCl2 untreated normal (negative) controls. The CdCl2 treated mice were divided into 3 subgroups, which were orally administered with the drug prior to, after and both prior to and after injection of CdCl2 at specific fixation intervals and their genotoxic effects were analyzed.
        
        
          Results
          While the CA, MNE and SHA were reduced in the drug fed series as compared to their respective controls, the MI showed an apparent increase. The combined pre- and post-feeding of Cad Sulph showed maximum reduction of the genotoxic effects.
        
        
          Conclusions
          Both Cad Sulph-30 and 200 were able to combat cadmium induced genotoxic effects in mice and that combined pre- and post-feeding mode of administration was found to be most effective in reducing the genotoxic effect of CdCl2 followed by the post-feeding mode.

Tags: cadmium-sulphoricum, cadmium-toxicity, genotoxicity-mice, homeopathic-drug, nih
Organization: U.S. Department of Health & Human Services
2019 Uniform Reporting System (URS) Table for Mississippi

These are the 2019 Uniform Reporting System (URS) Output Tables for Mississippi. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: mental-health-services, mississippi, national-outcome-measures, samhsa, urs-data
Organization: U.S. Department of Health & Human Services
Alveolar epithelial type II cell: defender of the alveolus revisited

In 1977, Mason and Williams developed the concept of the alveolar epithelial type II (AE2) cell as a defender of the alveolus. It is well known that AE2 cells synthesise, secrete, and recycle all components of the surfactant that regulates alveolar surface tension in mammalian lungs. AE2 cells influence extracellular surfactant transformation by regulating, for example, pH and [Ca2+] of the hypophase. AE2 cells play various roles in alveolar fluid balance, coagulation/fibrinolysis, and host defence. AE2 cells proliferate, differentiate into AE1 cells, and remove apoptotic AE2 cells by phagocytosis, thus contributing to epithelial repair. AE2 cells may act as immunoregulatory cells. AE2 cells interact with resident and mobile cells, either directly by membrane contact or indirectly via cytokines/growth factors and their receptors, thus representing an integrative unit within the alveolus. Although most data support the concept, the controversy about the character of hyperplastic AE2 cells, reported to synthesise profibrotic factors, proscribes drawing a definite conclusion today.

Tags: alveolar-epithelial-cells, alveolar-repair, lung-physiology, nih, pulmonary-surfactant
Organization: U.S. Department of Health & Human Services
Court Improvement Program

Section 438 of Title IV-B, subpart 2 of the Social Security Act sets aside funding for the Court Improvement Program (CIP).   The State CIP is a mandatory formula grant available to the highest court of appeal in every state, the District of Columbia, Puerto Rico and the U.S. Virgin Islands.  The purpose of the CIP is to: (1) promote the continuous quality improvement of court processes and legal representation in child welfare proceedings through ongoing data analysis, assessment, interventions and training, and (2) enhance and expand collaboration between the judicial branch of state government, the title IV-E/IV-B agency and tribes to improve child welfare outcomes.  In addition to the State CIP formula grants, approximately $1 million is set aside for Tribal CIP. These funds are awarded competitively.

The formula for the State CIP grants provides State courts with an approved application, a $255,000 base allotment plus, after the sum of all states’ base amounts and the $1 million set aside for grants to tribes are subtracted from the total appropriation, a percentage of the remainder based on the state’s proportionate share of children under age 21.

Budget Information:FY 2024 Funding:  approximately $31 million

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: child, fiscal, grant, intervention, policy
Organization: U.S. Department of Health & Human Services
Compound 528386: 3,4-Dichloro-2-hydroxybenzaldehyde

Chemical compound data from PubChem database. IUPAC Name: 3,4-dichloro-2-hydroxybenzaldehyde. Molecular Formula: C7H4Cl2O2. Molecular Weight: 191.01. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
A rate equation model of stomatal responses to vapour pressure deficit and drought

Background
          Stomata respond to vapour pressure deficit (D) – when D increases, stomata begin to close. Closure is the result of a decline in guard cell turgor, but the link between D and turgor is poorly understood. We describe a model for stomatal responses to increasing D based upon cellular water relations. The model also incorporates impacts of increasing levels of water stress upon stomatal responses to increasing D.
        
        
          Results
          The model successfully mimics the three phases of stomatal responses to D and also reproduces the impact of increasing plant water deficit upon stomatal responses to increasing D. As water stress developed, stomata regulated transpiration at ever decreasing values of D. Thus, stomatal sensitivity to D increased with increasing water stress. Predictions from the model concerning the impact of changes in cuticular transpiration upon stomatal responses to increasing D are shown to conform to experimental data.
          Sensitivity analyses of stomatal responses to various parameters of the model show that leaf thickness, the fraction of leaf volume that is air-space, and the fraction of mesophyll cell wall in contact with air have little impact upon behaviour of the model. In contrast, changes in cuticular conductance and membrane hydraulic conductivity have significant impacts upon model behaviour.
        
        
          Conclusion
          Cuticular transpiration is an important feature of stomatal responses to D and is the cause of the 3 phase response to D. Feed-forward behaviour of stomata does not explain stomatal responses to D as feedback, involving water loss from guard cells, can explain these responses.

Tags: nih, plant-water-stress, stomatal-conductance, vapor-pressure-deficit, vapour-pressure-deficit
Organization: U.S. Department of Health & Human Services
The genetics of rheumatoid arthritis and the need for animal models to find and understand the underlying genes

The causes of rheumatoid arthritis (RA) are largely unknown. However, RA is most probably a multifactorial disease with contributions from genetic and environmental factors. Searches for genes that influence RA have been conducted in both human and experimental model materials. Both types of study have confirmed the polygenic inheritance of the disease. It has become clear that the features of RA complicate the human genetic studies. Animal models are therefore valuable tools for identifying genes and determining their pathogenic role in the disease. This is probably the fastest route towards unravelling the pathogenesisis of RA and developing new therapies.

Tags: animal-models, disease-pathogenesis, genetic-factors, nih, rheumatoid-arthritis
Organization: U.S. Department of Health & Human Services
2020 Uniform Reporting System (URS) Table For Palau

This is the 2020 Uniform Reporting System (URS) Output Tables for Palau. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, national-outcome-measures, palau-health-data, samhsa
Organization: U.S. Department of Health & Human Services
NSDUH 2021 Pill Images for the NSDUH Questionnaire

This report contains the pill images used in the ACASI portion of the NSDUH questionnaire. These images are copyrighted and may not be reproduced. The owner of the copyright is SFI Medical Publishing of Lawrence, Kansas.

Tags: drug-recognition, nsduh-questionnaire, pill-identification, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
Compound 527313: Methyl 2-[3-(4-methoxyphenoxy)phenyl]propanoate

Chemical compound data from PubChem database. IUPAC Name: methyl 2-[3-(4-methoxyphenoxy)phenyl]propanoate. Molecular Formula: C17H18O4. Molecular Weight: 286.32. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services