AndreaBozzo/ceres-open-data-index huggingface dataset:
2020 Uniform Reporting System (URS) Table For Nebraska

This is the 2020 Uniform Reporting System (URS) Output Tables for Nebraska. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-data, mental-health-services, national-outcome-measures, nebraska-mental-health, samhsa
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Oklahoma, 2015

This is a behavioral health report for the state of Oklahoma. The report utilizes data from the National Survey on Drug Use and Health (NSDUH), and the Uniform Reporting System. The topics addressed in the report include youth substance use, youth mental health and treatment, mental health and treatment, substance use and substance use treatment.

Tags: mental-health-treatment, nsduh-data, oklahoma-behavioral-health, samhsa, youth-substance-use
Organization: U.S. Department of Health & Human Services
The method of bladder drainage in spinal cord injury patients may influence the histological changes in the mucosa of neuropathic bladder – a hypothesis

Background
          In spinal cord injury (SCI) patients, no correlation was found between the number of bladder infections per year, the period since injury, the neurologic level of the spinal cord lesion and the histopathology of the urinary bladder mucosa. The use of chronic indwelling urethral and/or suprapubic catheters in SCI patients is often associated with inflammatory and proliferative pathological conditions in neuropathic bladder.
        
        
          Presentation of the hypothesis
          We propose a hypothesis that the type of bladder drainage in SCI patients influences the histological changes in the mucosa of neuropathic bladder. This hypothesis implies that SCI patients with long-term indwelling urinary catheters develop certain histological changes in bladder mucosa, which are seen less frequently in SCI patients, who do not use long-term indwelling catheters. The latter group includes patients, who perform regular intermittent catheterisation and those, who wear a penile sheath and empty their bladders satisfactorily by reflex voiding.
          We hypothesise that the following histological lesions are seen more frequently in the neuropathic bladder of SCI patients with long-term indwelling catheters.
          (1) Papillary or polypoid cystitis; (2) widespread cystitis glandularis; (3) moderate to severe, acute and chronic inflammatory changes in bladder mucosa; (4) follicular cystitis; (5) squamous metaplasia; and (6) urothelial dysplasia
          As per this hypothesis, it is postulated that the above pathological conditions are seen less often in SCI patients, who achieve complete, low-pressure emptying of the neuropathic bladder by regular intermittent catheterisation, and SCI patients with penile sheath drainage, who empty their bladders satisfactorily by reflex voiding.
        
        
          Testing the hypothesis
          A large prospective study of bladder biopsies in SCI patients practising different methods of bladder drainage is required to validate this hypothesis that the histological changes in bladder mucosa are related to the method of bladder drainage in SCI patients.
        
        
          Implications of the hypothesis
          We propose a hypothesis that the method of bladder drainage in SCI patients influences histological changes in the bladder mucosa. If this hypothesis is validated, methods of bladder drainage such as intermittent catheterisation, which do not require the use of chronic indwelling catheters, should be recommended, in order to minimise adverse histological changes in the mucosa of neuropathic bladder of spinal cord injury patients.

Tags: bladder-drainage, histopathology, neuropathic-bladder, nih, spinal-cord-injury
Organization: U.S. Department of Health & Human Services
NSDUH 2022 Statistical Inference Report

Learn how to produce basic estimates with the 2022 National Survey on Drug Use and Health (NSDUH). The report describes the techniques that were used to make the 2022 NSDUH Detailed Tables and the 2022 NSDUH Annual National Report, but users may also find these techniques useful for their own research with NSDUH. The report describes the calculation of estimates and sampling errors, degrees of freedom, and the procedures for determining when low-precision estimates should be suppressed. It also includes sample code in several statistical languages that data users can modify to use in their own research.Chapters:Introduction to the report.Background on the survey design, including redesign and questionnaire changes.Prevalence estimates and how they were calculated, including specifics on various topics presented in the detailed tables.Discussion of how missing item responses of variables that are not imputed may lead to biased estimates.Discussion of sampling errors and how they were calculated.Description of degrees of freedom and how they were used to compare estimates.Discussion of how the statistical significance of differences between estimates was determined.Discussion of confidence interval estimation.Discussion of when estimates with low precision were suppressed.Appendix A contains code samples for various statistical procedures documented within the report.

Tags: mental-health, samhsa, statistical-inference, substance-use, survey-methodology
Organization: U.S. Department of Health & Human Services
From fruitflies to mammals: mechanisms of signalling via the Sonic hedgehog pathway in lung development

The hedgehog signalling pathway has been implicated in many different processes in fly and vertebrate development. It is now known that the hedgehog cascade is crucial for the patterning of the early respiratory system. Hedgehog signalling in the lung involves Gli transcription proteins, but their potential downstream target genes have yet to be identified. Bmp4 and Fgf10 have been shown to regulate lung branching morphogenesis but seem not to be targets of hedgehog signalling.

Tags: gli-proteins, lung-development, nih, signaling-pathway, sonic-hedgehog
Organization: U.S. Department of Health & Human Services
2017 Uniform Reporting System (URS) Table for Oklahoma

This is the 2017 Uniform Reporting System (URS) Output Tables for Oklahoma. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: mental-health-services, national-outcome-measures, oklahoma, samhsa, urs-data
Organization: U.S. Department of Health & Human Services
Astroglial expression of the P-glycoprotein is controlled by intracellular CNTF

Background
          The P-glycoprotein (P-gp), an ATP binding cassette transmembrane transporter, is expressed by astrocytes in the adult brain, and is positively modulated during astrogliosis. In a search for factors involved in this modulation, P-gp overexpression was studied in long-term in vitro astroglial cultures.
        
        
          Results
          Surprisingly, most factors that are known to induce astroglial activation in astroglial cultures failed to increase P-gp expression. The only effective proteins were IFNγ and those belonging to the IL-6 family of cytokines (IL-6, LIF, CT-1 and CNTF). As well as P-gp expression, the IL-6 type cytokines - but not IFNγ - stimulated the expression of endogenous CNTF in astrocytes. In order to see whether an increased intracellular level of CNTF was necessary for induction of P-gp overexpression by IL-6 type cytokines, by the same cytokines analysis was carried out on astrocytes obtained from CNTF knockout mice. In these conditions, IFNγ produced increased P-gp expression, but no overexpression of P-gp was observed with either IL-6, LIF or CT-1, pointing to a role of CNTF in the intracellular signalling pathway leading to P-gp overexpression. In agreement with this suggestion, application of exogenous CNTF -which is internalised with its receptor - produced an overexpression of P-gp in CNTF-deficient astrocytes.
        
        
          Conclusions
          These results reveal two different pathways regulating P-gp expression and activity in reactive astrocytes, one of which depends upon the intracellular concentration of CNTF. This regulation of P-gp may be one of the long searched for physiological roles of CNTF.

Tags: astroglial-cells, cntf-expression, il-6-cytokines, nih, p-glycoprotein
Organization: U.S. Department of Health & Human Services
Georgia (GA)

This report uses 2008 to 2010 National Survey on Drug Use and Health (NSDUH) to assess past year alcohol use disorder and illicit drug use disorder among persons aged 12 or older for Georgia overall and for substate regions within Georgia. Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE).

Tags: georgia-behavioral-health, mental-health-indicators, nsduh-data, samhsa, substance-use-disorder
Organization: U.S. Department of Health & Human Services
Evaluating Coverage of Selected Domains in the National Survey on Drug Use and Health

This report evaluates NSDUH\'s coverage of several demographic, socioeconomic, and geographic domains or subpopulations that are of interest to data users. It is intended to be an informative summary of NSDUH coverage with respect to other sources of data. In most cases, the data source that is used for comparison is a primary source of information on that domain or another flagship survey of HHS.

Tags: drug-use-survey, nsduh-coverage, samhsa, subpopulation-analysis, survey-comparison
Organization: U.S. Department of Health & Human Services
2014 CMHS Uniform Reporting System (URS) Table for South Dakota

2014 Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for South Dakota. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant, mental-health-services, outcome-measures, samhsa, south-dakota
Organization: U.S. Department of Health & Human Services
2012-2014 Substate Estimates of Substance Use and Mental Illness

Substate estimates for 25 measures of substance use and mental illness based on the combined 2012, 2013, and 2014 National Surveys on Drug Use and Health (NSDUHs) are provided. NSDUH is an ongoing survey of the civilian, noninstitutionalized population of the United States aged 12 years or older. Estimates presented here are based on a small area estimation (SAE) methodology in which substate-level NSDUH data are combined with county and census block group/tract-level data from the state.

Tags: mental-illness, nsduh-data, samhsa, small-area-estimation, substance-use
Organization: U.S. Department of Health & Human Services
2020 Uniform Reporting System (URS) Table For Ohio

This is the 2020 Uniform Reporting System (URS) Output Tables for Ohio. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: mental-health-services, national-outcome-measures, ohio-mental-health, samhsa, substance-abuse-treatment
Organization: U.S. Department of Health & Human Services
2018 Uniform Reporting System (URS) Table for Alabama

This is the 2018 Uniform Reporting System (URS) Output Tables for Alabama. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-program, mental-health-services, national-outcome-measures, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
Accessing and distributing EMBL data using CORBA (common object request broker architecture)

Background:
          The EMBL Nucleotide Sequence Database is a comprehensive database of DNA and RNA sequences and related information traditionally made available in flat-file format. Queries through tools such as SRS (Sequence Retrieval System) also return data in flat-file format. Flat files have a number of shortcomings, however, and the resources therefore currently lack a flexible environment to meet individual researchers' needs. The Object Management Group's common object request broker architecture (CORBA) is an industry standard that provides platform-independent programming interfaces and models for portable distributed object-oriented computing applications. Its independence from programming languages, computing platforms and network protocols makes it attractive for developing new applications for querying and distributing biological data.
        
        
          Results:
          A CORBA infrastructure developed by EMBL-EBI provides an efficient means of accessing and distributing EMBL data. The EMBL object model is defined such that it provides a basis for specifying interfaces in interface definition language (IDL) and thus for developing the CORBA servers. The mapping from the object model to the relational schema in the underlying Oracle database uses the facilities provided by PersistenceTM, an object/relational tool. The techniques of developing loaders and 'live object caching' with persistent objects achieve a smart live object cache where objects are created on demand. The objects are managed by an evictor pattern mechanism.
        
        
          Conclusions:
          The CORBA interfaces to the EMBL database address some of the problems of traditional flat-file formats and provide an efficient means for accessing and distributing EMBL data. CORBA also provides a flexible environment for users to develop their applications by building clients to our CORBA servers, which can be integrated into existing systems.

Tags: bioinformatics, dna-rna, nih, nucleotide-sequences, sequence-database
Organization: U.S. Department of Health & Human Services
Practising evidence-based medicine: the design and implementation of a multidisciplinary team-driven extubation protocol

Background
          Evidence from recent literature shows that protocol-directed extubation is a useful approach to liberate patients from mechanical ventilation (MV). However, research evidence does not necessarily provide guidance on how to implement changes in individual intensive care units (ICUs). We conducted the present study to determine whether such an evidence-based strategy can be implemented safely and effectively using a multidisciplinary team (MDT) approach.
        
        
          Method
          We designed a MDT-driven extubation protocol. Multiple meetings were held to encourage constructive criticism of the design by attending physicians, nurses and respiratory care practitioners (RCPs), in order to define a protocol that was evidence based and acceptable to all clinical staff involved in the process of extubation. It was subsequently implemented and evaluated in our medical/ surgical ICU. Outcomes included response of the MDT to the initiative, duration of MV and stay in the ICU, as well as reintubation rate.
        
        
          Results
          The MDT responded favourably to the design and implementation of this MDT-driven extubation protocol, because it provided greater autonomy to the staff. Outcomes reported in the literature and in the historical control group were compared with those in the protocol group, and indicated similar durations of MV and ICU stay, as well as reintubation rates. No adverse events were documented.
        
        
          Conclusion
          An MDT approach to protocol-directed extubation can be implemented safely and effectively in a multidisciplinary ICU. Such an effort is viewed favourably by the entire team and is useful in enhancing team building.

Tags: extubation-protocol, icu-weaning, mechanical-ventilation, multidisciplinary-team, nih
Organization: U.S. Department of Health & Human Services
Mental Health Annual Report 2016

This report presents results from the Mental Health Client-Level Data (MH-CLD) and Mental Health Treatment Episode Data Set (MH-TEDS) for individuals receiving mental health treatment services in 2016, as well as selected trends in data collected from such individuals between 2013 and 2016. The report provides information on mental health diagnoses, mental health treatment services, and demographic and substance use characteristics of individuals in mental health treatment in facilities that reported to individual state administrative data systems.

Tags: client-level-data, mental-health, samhsa, substance-use, treatment-episodes
Organization: U.S. Department of Health & Human Services
2011 State Profile — Wisconsin

This is a National Survey of Substance Abuse Treatment Services (N-SSATS) data table showing state profile for Wisconsin in 2011. N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 States, the District of Columbia, and other U.S. jurisdictions.

Tags: alcohol-drug-services, samhsa, substance-abuse-treatment, treatment-facility-data, wisconsin-health
Organization: U.S. Department of Health & Human Services
Genetic linkage and transmission disequilibrium of marker haplotypes at chromosome 1q41 in human systemic lupus erythematosus

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the production of autoantibodies to a wide range of self-antigens. Recent genome screens have implicated numerous chromosomal regions as potential SLE susceptibility loci. Among these, the 1q41 locus is of particular interest, because evidence for linkage has been found in several independent SLE family collections. Additionally, the 1q41 locus appears to be syntenic with a susceptibility interval identified in the NZM2410 mouse model for SLE. Here, we report the results of genotyping of 11 microsatellite markers within the 1q41 region in 210 SLE sibpair and 122 SLE trio families. These data confirm the modest evidence for linkage at 1q41 in our family collection (LOD = 1.21 at marker D1S2616). Evidence for significant linkage disequilibrium in this interval was also found. Multiple markers in the region exhibit transmission disequilibrium, with the peak single marker multiallelic linkage disequilibrium noted at D1S490 (pedigree disequilibrium test [PDT] global P value = 0.0091). Two- and three-marker haplotypes from the 1q41 region similarly showed strong transmission distortion in the collection of 332 SLE families. The finding of linkage together with significant transmission disequilibrium provides strong evidence for a susceptibility locus at 1q41 in human SLE.

Tags: autoimmune-disease, chromosome-1q41, genetic-linkage, nih, systemic-lupus-erythematosus
Organization: U.S. Department of Health & Human Services
NSDUH 2013 Methodological Resource Book (MRB)

This Methodological Resource Book (MRB) is intended to serve as documentation of survey materials and methodology associated with the 2013 National Survey on Drug Use and Health (NSDUH). The MRB includes details associated with data collection and processing, including sampling, instrument testing and development, weighting, imputation, and statistical analyses and inferences.

Tags: data-collection, samhsa, statistical-analysis, substance-use, survey-methodology
Organization: U.S. Department of Health & Human Services
Comparison of the 2021-2022 and 2022-2023 State Prevalence Tables

Examine the change in state estimates between 2021-2022 and 2022-2023 from the National Surveys on Drug Use and Health (NSDUH) and determine if they were statistically significant using p-values. The tables accompany the2022-2023 NSDUH State Estimates of Substance Use and Mental Health, and include estimates for both time periods, as well as a p-value for determining statistical significance. There is also a guide to the methodology used to calculate the p-values.The tables are available in PDF or HTML format.

Tags: mental-health, nsduh-data, samhsa, state-prevalence, substance-use
Organization: U.S. Department of Health & Human Services
Report to Congress on Efforts to Coordinate Programs and Activities Related to Child Abuse and Neglect (2012)

This report to Congress provides a description of key efforts of the Children's Bureau and its Office on Child Abuse and Neglect in the coordination of programs and activities related to child abuse and neglect from June 1999 to September 2012.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: abuse, neglect, policy, prevention, reporting
Organization: U.S. Department of Health & Human Services
Herpes simplex virus bullous keratitis misdiagnosed as a case of pseudophakic bullous keratopathy with secondary glaucoma: an unusual presentation

Purpose
          To report an unusual case of herpetic bullous keratitis misdiagnosed as a case of pseudophakic bullous keratopathy with secondary glaucoma.
        
        
          Results
          A retrospective analysis of the case record of a 60-year-old man who had earlier undergone bilateral cataract surgery, was done. He presented with a complaint of decrease in vision in the right eye of 20 days duration. On examination, cornea showed epithelial bullae all over the surface with stromal and epithelial edema. Intraocular pressure was 30 mm of Hg in RE. He was treated with anti-glaucoma medications. Two dendritic lesions were seen in the cornea during a subsequent visit four days later. Virological investigations confirmed a diagnosis of Herpes simplex keratitis. He was treated with topical acyclovir.
        
        
          Conclusions
          This case highlights the fact that herpes simplex keratitis can present initially as a more diffuse corneal stromal and epithelial edema with epithelial bullae mimicking bullous keratopathy. Herpetic bullous keratitis, although unusual, should be considered in the differential diagnosis under such circumstances.

Tags: bullous-keratopathy, corneal-disease, herpes-simplex-keratitis, nih, secondary-glaucoma
Organization: U.S. Department of Health & Human Services
2015 Mental Health Client-Level Data Report (MH-CLD)

This report presents results from the Mental Health Client-Level Data (MH-CLD) and Mental Health Treatment Episode Data Set (MH-TEDS) for individuals receiving mental health treatment services in 2015, as well as selected data collection trends for such individuals from 2012 to 2015. The report provides information on mental health diagnoses, mental health treatment services, and demographic and substance use characteristics of individuals in mental health treatment in facilities that reported to individual state administrative data systems. One chapter is also devoted to characteristics of admissions to and discharges from mental health treatment, which can feature the same individual on multiple occasions.

Tags: client-level-data, mental-health, mental-health-services, samhsa, treatment-episodes
Organization: U.S. Department of Health & Human Services