AndreaBozzo/ceres-open-data-index huggingface dataset:
A successful pregnancy following SEM fine tuning of hormonal priming

Background
          Manipulation of the uterine epithelium utilising standard dose exogenous oestrogen (E2) and progesterone (P4) has been shown to achieve a mature secretory morphological response. However, in an in vitro fertilisation (IVF) setting, frozen embryo transfer (ET) has had a low success rate. We propose that in patients with previously failed ET attempts, the uterine epithelium can be directly visualised by biopsy and Scanning Electron Microscopy (SEM) and that with an individualised fine tuning of the hormone supplementation regime, based on the SEM examination of sequential uterine biopsies, it is possible to provide a uterine environment conducive to successful ET.
        
        
          Methods
          A 47 year old women was chosen for endometrial biopsy, histopathological dating and endometrial observation utilising SEM to determine the integrity of her secretory uterine epithelium because of her age and several previously failed attempts at frozen ET. Exogenous E2 and P4 supplementation was administered in modified doses according to the SEM result, in consecutive cycles until the epithelial response appeared satisfactory for potential implantation.
        
        
          Results
          This case study demonstrates the dramatic change in epithelial characteristics that can be achieved as a response to these altered doses of E2 and P4. The uterine morphology changed from a hypotrophic to a mature, receptive epithelium such that ET resulted in the birth of healthy twin boys.
        
        
          Conclusion
          The comparison between the consecutive biopsies in direct response to the SEM analysis and tailored modification of E2 and P4 dose clearly demonstrates, in this case, the effectiveness of individual morphological monitoring to maximise the successful outcome of ET.

Tags: endometrial-biopsy, frozen-embryo-transfer, hormone-therapy, nih, uterine-receptivity
Organization: U.S. Department of Health & Human Services
Adoption Data 2008

This page includes reports on state-specific adoption statistics for fiscal year 2008.

Receiving Adoption Subsidy: 10/1/2007 - 9/30/2008
Adoptive Family Structure: 10/1/2007 - 9/30/2008
Age at Adoption Finalization: 10/1/2007 - 9/30/2008
Prior Relationship of Adoptive Parent(s) to Child: 10/1/2007 - 9/30/2008
Race/Ethnicity of Public Agency Children Adopted: 10/1/2007 - 9/30/2008
Sex of Public Agency Children Adopted: 10/1/2007 - 9/30/2008
Child is Identified as a Special Needs Adoption: 10/1/2007 - 9/30/2008
Time between Termination of Parental Rights (TPR) and Adoption Finalization: 10/1/2007 - 9/30/2008

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: adoption, child, data, fiscal, policy
Organization: U.S. Department of Health & Human Services
2018 Uniform Reporting System (URS) Table for District of Columbia

This is the 2018 Uniform Reporting System (URS) Output Tables for District of Columbia. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-program, mental-health-services, national-outcome-measures, samhsa, substance-abuse-treatment
Organization: U.S. Department of Health & Human Services
Using evidence from different sources: an example using paracetamol 1000 mg plus codeine 60 mg

Background
          Meta-analysis usually restricts the information pooled, for instance using only randomised, double-blind, placebo-controlled trials. This neglects other types of high quality information. This review explores using different information for the combination of paracetamol 1000 mg and codeine 60 mg in acute postoperative pain.
        
        
          Results
          Randomised, double-blind, placebo-controlled trials of paracetamol 1000 mg and codeine 60 mg had an NNT of 2.2 (95% confidence interval 1.7 to 2.9) for at least 50% pain relief over four to six hours in three trials with 197 patients. Computer simulation of randomised trials demonstrated 92% confidence that the simulated NNT was within ± 0.5 of the underlying value of 2.2 with this number of patients. The result was supported a rational dose-response relationship for different doses of paracetamol and codeine in 17 additional trials with 1,195 patients. Three controlled trials lacking a placebo and with 117 patients treated with of paracetamol 1000 mg and codeine 60 mg had 73% (95%CI 56% to 81%) of patients with at least 50% pain relief, compared with 57% (48% to 66%) in placebo controlled trials. Six trials in acute pain were omitted because of design issues, like the use of different pain measures or multiple dosing regimens. In each paracetamol 1000 mg and codeine 60 mg was shown to be better than placebo or comparators for at least one measure.
        
        
          Conclusions
          Different designs of high quality trials can be used to support limited information used in meta-analysis without recourse to low quality trials that might be biased.

Tags: meta-analysis, nih, pain-relief, paracetamol-codeine, postoperative-pain
Organization: U.S. Department of Health & Human Services
Research Article: Genome Biology

Background
          Computational predictions are critical for directing the experimental study of protein functions. Therefore it is paradoxical when an apparently erroneous computational prediction seems to be supported by experiment.
        
        
          Results
          We analyzed six cases where application of novel or conventional computational methods for protein sequence and structure analysis led to non-trivial predictions that were subsequently supported by direct experiments. We show that, on all six occasions, the original prediction was unjustified, and in at least three cases, an alternative, well-supported computational prediction, incompatible with the original one, could be derived. The most unusual cases involved the identification of an archaeal cysteinyl-tRNA synthetase, a dihydropteroate synthase and a thymidylate synthase, for which experimental verifications of apparently erroneous computational predictions were reported. Using sequence-profile analysis, multiple alignment and secondary-structure prediction, we have identified the unique archaeal 'cysteinyl-tRNA synthetase' as a homolog of extracellular polygalactosaminidases, and the 'dihydropteroate synthase' as a member of the β-lactamase-like superfamily of metal-dependent hydrolases.
        
        
          Conclusions
          In each of the analyzed cases, the original computational predictions could be refuted and, in some instances, alternative strongly supported predictions were obtained. The nature of the experimental evidence that appears to support these predictions remains an open question. Some of these experiments might signify discovery of extremely unusual forms of the respective enzymes, whereas the results of others could be due to artifacts.

Tags: computational-prediction, genome-biology, nih, protein-function, sequence-analysis
Organization: U.S. Department of Health & Human Services
Georgia (GA)

This report presents estimates for measures of substance use and mental health based on the combined 2010 and 2011 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for Georgia for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: georgia-survey, illicit-drug-use, mental-health, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
AFCARS Report #24

This report provides preliminary estimates of Adoption and Foster Care Analysis and Reporting System (AFCARS) data for FY 2016. As states are permitted to resubmit AFCARS data, the estimates may change over time. This report reflects all AFCARS data received as of October 20, 2017 related to AFCARS reporting periods through September 30, 2016.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: adoption, care, foster, policy, reporting
Organization: U.S. Department of Health & Human Services
Small airway inflammation in asthma

Asthma was originally described as an inflammatory disease that predominantly involves the central airways. Pathological and physiological evidence reported during the past few years suggests that the inflammatory process extends beyond the central airways to the peripheral airways and the lung parenchyma. The small airways are capable of producing T-helper-2 cytokines, as well as chemokines, and they have recently been recognized as a predominant site of airflow obstruction in asthmatic persons. The inflammation at this distal site has been described as more severe than large airway inflammation. These findings are of great clinical significance, and highlight the need to consider the peripheral airways as a target in any therapeutic strategy for treatment of asthma.

Tags: asthma-inflammation, asthma-pathophysiology, nih, peripheral-airways, small-airway-inflammation
Organization: U.S. Department of Health & Human Services
Guidelines for conducting time-limited information technology demonstration  projects (pilots) in a Comprehensive Child Welfare Information System (CCWIS) environment

This Program Instruction (PI) provides state and tribal title IV-E agencies (agencies) guidance and describes the documentation requirements an agency must complete to maintain compliance with CCWIS requirements while evaluating new child welfare business processes, tools, or information technologies through pilots.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: child, compliance, guidance, instruction, policy
Organization: U.S. Department of Health & Human Services
Effect of simvastatin on bone markers in osteopenic women: a placebo-controlled, dose-ranging trial [ISRCTN85429598]

Background
          Hydroxymethylglutaryl coenzyme A reductase inhibitors increase new bone formation in vitro and in rodents. Results of epidemiologic analyses evaluating the association between use of these cholesterol-lowering drugs, bone mineral density and fracture have been mixed.
        
        
          Methods
          Women (n = 24) with osteopenia, assessed by broad band ultrasound attenuation, were randomized to simvastatin 20 mg, 40 mg or identical-appearing placebo for 12 weeks. Fasting lipid profiles and biochemical markers of bone formation (bone-specific alkaline phosphatase) and resorption (N-telopeptides and C-terminal propeptide of type 1 collagen) were measured at baseline, 6 and 12 weeks.
        
        
          Results
          Plasma low density lipoprotein-cholesterol concentration fell 7%, 39% (p < 0.01 vs baseline) and 47% (p < 0.01 vs baseline) after 12 weeks of treatment with placebo, simvastatin 20 mg and 40 mg, respectively. At baseline, bone marker concentrations were similar in the three treatment groups. At 6 and 12 weeks, bone marker concentrations were not different from baseline, and no significant differences in bone marker concentrations were observed between treatment groups at either 6 or 12 weeks.
        
        
          Conclusion
          Among osteopenic women, treatment with simvastatin for 12 weeks did not affect markers of bone formation or resorption.

Tags: bone-markers, clinical-trial, nih, osteopenia, simvastatin
Organization: U.S. Department of Health & Human Services
Validation and results of a questionnaire for functional bowel disease in out-patients

Background
          The aim was to evaluate and validate a bowel disease questionnaire in patients attending an out-patient gastroenterology clinic in Greece.
        
        
          Methods
          This was a prospective study. Diagnosis was based on detailed clinical and laboratory evaluation. The questionnaire was tested on a pilot group of patients. Interviewer-administration technique was used. One-hundred-and-forty consecutive patients attending the out-patient clinic for the first time and fifty healthy controls selected randomly participated in the study. Reliability (kappa statistics) and validity of the questionnaire were tested. We used logistic regression models and binary recursive partitioning for assessing distinguishing ability among irritable bowel syndrome (IBS), functional dyspepsia and organic disease patients.
        
        
          Results
          Mean time for questionnaire completion was 18 min. In test-retest procedure a good agreement was obtained (kappa statistics 0.82). There were 55 patients diagnosed as having IBS, 18 with functional dyspepsia (Rome I criteria), 38 with organic disease. Location of pain was a significant distinguishing factor, patients with functional dyspepsia having no lower abdominal pain (p < 0.001). Significant factors distinguishing between IBS and functional dyspepsia were relief of pain by either antacids or defecation (19% vs 71% and 66% vs 0% respectively). Awakening from pain at night was also a factor distinguishing between IBS and organic disease groups (26% vs 61%, p < 0.01).
        
        
          Conclusions
          This questionnaire for functional bowel disease is a valid and reliable instrument that can distinguish satisfactorily between organic and functional disease in an out-patient setting.

Tags: functional-bowel-disease, gastroenterology-clinic, irritable-bowel-syndrome, nih, questionnaire-validation
Organization: U.S. Department of Health & Human Services
Ultrastructure of acetylcholine receptor aggregates parallels mechanisms of aggregation

Background
          Acetylcholine receptors become aggregated at the developing neuromuscular synapse shortly after contact by a motorneuron in one of the earliest manifestations of synaptic development. While a major physiological signal for receptor aggregation (agrin) is known, the mechanism(s) by which muscle cells respond to this and other stimuli have yet to be worked out in detail. The question of mechanism is addressed in the present study via a quantitative examination of ultrastructural receptor arrangement within aggregates.
        
        
          Results
          In receptor rich cell membranes resulting from stimulation by agrin or laminin, or in control membrane showing spontaneous receptor aggregation, receptors were found to be closer to neighboring receptors than would be expected at random. This indicates that aggregation proceeds heterogeneously: nanoaggregates, too small for detection in the light microscope, underlie developing microaggregates of receptors in all three cases. In contrast, the structural arrangement of receptors within nanoaggregates was found to depend on the aggregation stimulus. In laminin induced nanoaggregates receptors were found to be arranged in an unstructured manner, in contrast to the hexagonal array of about 10 nm spacing found for agrin induced nanoaggregates. Spontaneous aggregates displayed an intermediate amount of order, and this was found to be due to two distinct population of nanoaggregates.
        
        
          Conclusions
          The observations support earlier studies indicating that mechanisms by which agrin and laminin-1 induced receptor aggregates form are distinct and, for the first time, relate mechanisms underlying spontaneous aggregate formation to aggregate structure.

Tags: acetylcholine-receptors, agrin-stimulation, neuromuscular-synapse, nih, receptor-aggregation
Organization: U.S. Department of Health & Human Services
Mental health first aid training for the public: evaluation of effects on knowledge, attitudes and helping behavior

Background
          Many members of the public have poor mental health literacy. A Mental Health First Aid training course was developed in order to improve this. This paper describes the training course and reports an evaluation study looking at changes in knowledge, stigmatizing attitudes and help provided to others.
        
        
          Methods
          Data are reported on the first 210 participants in public courses. Evaluation questionnaires were given at the beginning of courses, at the end and at 6 months follow-up. Data were analyzed using an intention-to-treat approach.
        
        
          Results
          The course improved participants' ability to recognize a mental disorder in a vignette, changed beliefs about treatment to be more like those of health professionals, decreased social distance from people with mental disorders, increased confidence in providing help to someone with a mental disorder, and increased the amount of help provided to others.
        
        
          Conclusions
          Mental Health First Aid training appears to be an effective method of improving mental health literacy which can be widely applied.

Tags: helping-behavior, mental-health-first-aid, mental-health-literacy, nih, stigma-reduction
Organization: U.S. Department of Health & Human Services
Encephalomeningocele cases over 10 years in Thailand: a case series

Background
          Encephalomeningocele, especially in the frontoethmoidal region, is a form of neural tube defect which affects patients in Southeast Asia more commonly than in Western countries. Its underlying cause is not known but teratogenic environmental agents are suspected. However, nutritional deficiency, as in spina bifida, cannot be excluded.
        
        
          Methods
          This study reports 21 cases of meningocele (without brain tissue in the lesion) and encephalomeningocele (with brain tissue) that were admitted to our hospital for surgical corrections in the period of ten years, from 1990 to 1999. Clinicopathological findings, as well as occupations of family members and prenatal exposures to infectious agents or chemicals were reviewed and analyzed.
        
        
          Results
          The most commonly involved area was the frontoethmoidal region, found in 20 cases. The combined pattern between nasoethmoidal and nasoorbital defects was found most frequently (11 from 21 cases) and had more associated abnormalities. Encephalomeningocele had more related abnormalities than meningocele with proportions of 0.6 and 0.3, respectively.
        
        
          Conclusions
          Here, we confirmed that genetic defects are not likely to be the single primary cause of this malformation. However, we could not draw any conclusions on etiologic agents. We suggest that case control studies and further investigation on the role of nutritional deficiencies, especially folic acid, in the pathogenesis of encephalomeningocele are necessary to clarify the underlying mechanisms.

Tags: birth-defects, encephalomeningocele, neural-tube-defects, nih, thailand
Organization: U.S. Department of Health & Human Services
Demographic and Geographic Variations in Injection Drug Use

Research indicates that the use of injectable drugs, like the use of other illicit drugs, varies by demographic group and geographic area. Methamphetamine use from 2002 to 2004, for example, was more prevalent in the West than in other regions of the country. Analysis of 2003 treatment admissions involving clients who injected their drugs of abuse showed that their profiles by race/ethnicity, gender, and region varied depending on the types of drugs they injected. These findings suggest that there are differences in the rates of injection drug use depending on demographic and geographic characteristics.

Tags: drug-use-demographics, geographic-drug-patterns, injection-drug-use, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
2012 State Profile - Guam

This is a National Survey of Substance Abuse Treatment Services (N-SSATS) annual report showing the state profile for Guam in 2012. N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 States, the District of Columbia, and other U.S. jurisdictions.

Tags: behavioral-health-services, guam-health-data, n-ssats, samhsa, substance-abuse-treatment
Organization: U.S. Department of Health & Human Services
Cellulose acetate phthalate, a common pharmaceutical excipient, inactivates HIV-1 and blocks the coreceptor binding site on the virus envelope glycoprotein gp120

Background
          Cellulose acetate phthalate (CAP), a pharmaceutical excipient used for enteric film coating of capsules and tablets, was shown to inhibit infection by the human immunodeficiency virus type 1 (HIV-1) and several herpesviruses. CAP formulations inactivated HIV-1, herpesvirus types 1 (HSV-1) and 2 (HSV-2) and the major nonviral sexually transmitted disease (STD) pathogens and were effective in animal models for vaginal infection by HSV-2 and simian immunodeficiency virus.
        
        
          Methods
          Enzyme-linked immunoassays and flow cytometry were used to demonstrate CAP binding to HIV-1 and to define the binding site on the virus envelope.
        
        
          Results
          1) CAP binds to HIV-1 virus particles and to the envelope glycoprotein gp120; 2) this leads to blockade of the gp120 V3 loop and other gp120 sites resulting in diminished reactivity with HIV-1 coreceptors CXCR4 and CCR5; 3) CAP binding to HIV-1 virions impairs their infectivity; 4) these findings apply to both HIV-1 IIIB, an X4 virus, and HIV-1 BaL, an R5 virus.
        
        
          Conclusions
          These results provide support for consideration of CAP as a topical microbicide of choice for prevention of STDs, including HIV-1 infection.

Tags: cellulose-acetate-phthalate, coreceptor-blockade, gp120-binding, hiv-1-inactivation, nih
Organization: U.S. Department of Health & Human Services
Post-transcriptional regulation of pro-inflammatory gene expression

The cytokine tumour necrosis factor (TNF)α is a vital mediator of the innate immune response, and a pleiotropic regulator of cellular function. Its involvement in rheumatoid arthritis is illustrated by the clinical benefits of TNFα blockade. Post-transcriptional regulation (the control of mRNA stability and translation) appears to play a critical role in the regulation of TNFα expression by mitogen activated protein kinase signal transduction pathways and by anti-inflammatory agents. The aim of this article is to review some recent advances in our understanding of these processes, and to speculate on mechanisms of regulation of TNFα and other pro-inflammatory genes.

Tags: innate-immune-response, nih, post-transcriptional-regulation, pro-inflammatory-genes, tnf-alpha
Organization: U.S. Department of Health & Human Services
2014 CMHS Uniform Reporting System (URS) Table for Vermont

2014 Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for Vermont. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, national-outcome-measures, samhsa, vermont
Organization: U.S. Department of Health & Human Services
Compound 525503: 6-Methyl-4,5-dithia-1-heptene

Chemical compound data from PubChem database. IUPAC Name: 2-(prop-2-enyldisulfanyl)propane. Molecular Formula: C6H12S2. Molecular Weight: 148.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services