AndreaBozzo/ceres-open-data-index huggingface dataset:
Profiles of Child Welfare Waiver Demonstration Projects active between 2012 to 2019 (March 2021)

This report outlines State title IV-E demonstration waivers that allowed flexibility in the use of federal funds for alternative services and supports that promoted safety, permanency, and well-being for children in the child protection and foster care systems.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: assessment, data, foster, policy, reporting
Organization: U.S. Department of Health & Human Services
Compound 525218: Chloromethyl 6-chlorononanoate

Chemical compound data from PubChem database. IUPAC Name: chloromethyl 6-chlorononanoate. Molecular Formula: C10H18Cl2O2. Molecular Weight: 241.15. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Child Maltreatment 2021

This report presents national data about child abuse and neglect known to child protective services agencies in the United States during federal fiscal year 2021.

Letter from the Associate Commissioner

Acknowledgements

Child Abuse and Neglect Data During the Pandemic

Summary

CHAPTER 1: Introduction

CHAPTER 2: Reports

CHAPTER 3: Children

CHAPTER 4: Fatalities

CHAPTER 5: Perpetrators

CHAPTER 6: Services

CHAPTER 7: Special Focus

APPENDIX A: CAPTA Data Items

APPENDIX B: Glossary

APPENDIX C: State Characteristics

APPENDIX D: State Commentary

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: abuse, assessment, fiscal, maltreatment, neglect
Organization: U.S. Department of Health & Human Services
Emergency Department Visits Involving Nonmedical Use of Central Nervous System Stimulants among Adults Aged 18 to 34 Increased between 2005 and 2011

This Drug Abuse Warning Network (DAWN) spotlight is about emergency department visits involving nonmedical use of central nervous system stimulants among adults age 18 to 34 increase between 2005 and 2011.

Tags: emergency-department, nonmedical-use, samhsa, stimulant-abuse, young-adults
Organization: U.S. Department of Health & Human Services
Evaluation of amplified rDNA restriction analysis (ARDRA) for the identification of cultured mycobacteria in a diagnostic laboratory

Background
          The development of DNA amplification for the direct detection of M. tuberculosis from clinical samples has been a major goal of clinical microbiology during the last ten years. However, the limited sensitivity of most DNA amplification techniques restricts their use to smear positive samples. On the other hand, the development of automated liquid culture has increased the speed and sensitivity of cultivation of mycobacteria. We have opted to combine automated culture with rapid genotypic identification (ARDRA: amplified rDNA restriction analysis) for the detection resp. identification of all mycobacterial species at once, instead of attempting direct PCR based detection from clinical samples of M. tuberculosis only.
        
        
          Results
          During 1998–2000 a total of approx. 3500 clinical samples was screened for the presence of M. tuberculosis. Of the 151 culture positive samples, 61 were M. tuberculosis culture positive. Of the 30 smear positive samples, 26 were M. tuberculosis positive. All but three of these 151 mycobacterial isolates could be identified with ARDRA within on average 36 hours. The three isolates that could not be identified belonged to rare species not yet included in our ARDRA fingerprint library or were isolates with an aberrant pattern.
        
        
          Conclusions
          In our hands, automated culture in combination with ARDRA provides with accurate, practically applicable, wide range identification of mycobacterial species. The existing identification library covers most species, and can be easily updated when new species are studied or described. The drawback is that ARDRA is culture-dependent, since automated culture of M. tuberculosis takes on average 16.7 days (range 6 to 29 days). However, culture is needed after all to assess the antibiotic susceptibility of the strains.

Tags: ardra-analysis, mycobacteria-identification, nih, rdna-restriction, tuberculosis-detection
Organization: U.S. Department of Health & Human Services
Results from the 2013 National Survey on Drug Use and Health: Mental Health Findings

This report present results from the 2013 National Survey on Drug Use and Health (NSDUH) Mental Health Findings, including national estimates of the prevalence of past year mental disorders and past year mental health service utilization for youths aged 12 to 17 and adults aged 18 or older. Among adults, estimates presented include rates and numbers of persons with any mental illness (AMI), serious mental illness (SMI), suicidal thoughts and behavior, major depressive episode (MDE), treatment for depression (among adults with MDE), and mental health service utilization. Estimates for youths include MDE, treatment for depression (among youths with MDE), and mental health service utilization. Measures related to the co-occurrence of mental disorders with substance use or with substance use disorders also are presented for both adults and youths. The report focuses mainly on trends between 2012 and 2013. Results are also provided by age group, gender, race/ethnicity, education level, employment status, county type, poverty level, insurance status, overal health, and geographic area.

Tags: ami-smi, depression-treatment, mental-health-survey, samhsa, substance-use-mental-health
Organization: U.S. Department of Health & Human Services
Compound 528453: 1-Nonene, 4,8-dimethyl

Chemical compound data from PubChem database. IUPAC Name: 4,8-dimethylnon-1-ene. Molecular Formula: C11H22. Molecular Weight: 154.29. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Tennessee: 2011-2012 NSDUH

This report presents Tennessee\'s estimates for 25 measures of substance use and mental health based on the combined 2011 and 2012 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided by State and for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: mental-health, samhsa, substance-use, survey-data, tennessee
Organization: U.S. Department of Health & Human Services
Treatment Episode Data Set (TEDS): 2019 Admissions to and Discharges from Publicly-Funded Substance Use Treatment

This report presents national- and state-level data from the Treatment Episode Data Set (TEDS) for admissions and discharges occurring in 2019, and trend data from 2009 to 2019. It summarizes demographic information and the characteristics and outcomes of treatment for alcohol and/or drug use among clients aged 12 years and older in facilities that report to individual state administrative data systems. Data include records for treatment admissions and discharges that were received and processed through November 3, 2020.

Tags: alcohol-drug-use, samhsa, substance-use-treatment, teds-admissions, treatment-outcomes
Organization: U.S. Department of Health & Human Services
The NSDUH Report: State Estimates of Underage Alcohol Use and Self-Purchase of Alcohol: 2008 to 2010

This short report uses 2008 to 2010 National Survey on Drug Use and Health (NSDUH) to assess past month alcohol use among those under the legal drinking age (12 to 20) and whether those underage drinkers self-purchased the alcohol. Results are shown by State.

Tags: alcohol-self-purchase, samhsa, state-alcohol-estimates, underage-alcohol-use, youth-alcohol-consumption
Organization: U.S. Department of Health & Human Services
Research Article: BMC Gastroenterology

Background
          The 13C-urea breath test (UBT) is performed in adults and children with epigastric pain for non-invasively diagnosing a suspected H. pylori infection. Criteria for UBT interpretation have not been generally agreed on and test reliability has not been established in children of different ages. This study aimed at identifying reliable UBT thresholds in children by using 251 UBTs in conjunction with reference histology and by analyzing 1232 UBTs.
        
        
          Methods
          At baseline and 30 and 60 minutes after the administration of 75 mg 13C-urea to children and adolescents (0.25 to 18 years of age), the differences (Δ) of 13CO2/12CO2 ratio in exhaled air (δ) were determined by mass spectrometry. UBT Δδ value thresholds were calculated in random subgroups and evaluated in complementary subgroups using logistic regressions on reference histology or bimodal distribution analyses of Δδ values from UBTs alone.
        
        
          Results
          Δδ values were higher (median, 15.4‰) in positive (133/251, 53 %) than in negative histology (2.4‰). At 30 minutes, the calculated cut-off was 5.3‰ (mean regression determination R2 = 0.91), and sensitivity (0.95), specificity (0.97), positive (0.97) and negative predictive values (0.95) were higher than at 60 minutes (threshold 6.8‰, R2 = 0.85). Similar thresholds resulted from UBTs analysis (5.8‰ and 6.2‰) when sensitivity and specificity were maximized (concordance probabilities, 0.99 and 0.99). There was no systematic age effect.
        
        
          Conclusions
          In children, 13C UBT cut-offs were obtained and specially validated, entailing high accuracy of non-invasively testing for gastric H. pylori infection.

Tags: diagnostic-thresholds, h-pylori-infection, nih, pediatric-gastroenterology, urea-breath-test
Organization: U.S. Department of Health & Human Services
Critical care medicine in the 21st century: from CPR to PCR

As in other areas of medicine, the specialty of critical care medicine, which has made important contributions in the pathophysiology of critical illness, is facing challenges that must be recognized and addressed in the current century. In this review, we argue that the skill set required to adequately treat critically ill patients will also require knowledge of molecular biology for better diagnosis and treatment. The foundations of molecular biology and genetics are essential for the understanding of the mechanisms of disease. Incorporating molecular biology techniques in the research arsenal of the intensivist will provide the opportunity to dissect out and define the reversible and irreversible intracellular processes giving rise to the major causes of mortality in intensive care units. Two historical paradigms, the cardiopulmonary resuscitation and polymerase chain reaction, summarize how critical care medicine began, and how it could mature in the years to come.

Tags: critical-care, critical-illness, intensive-care, molecular-biology, nih
Organization: U.S. Department of Health & Human Services
A missense mutation (Q279R) in the Fumarylacetoacetate Hydrolase gene, responsible for hereditary tyrosinemia, acts as a splicing mutation

Background
          Tyrosinemia type I, the most severe disease of the tyrosine catabolic pathway is caused by a deficiency in fumarylacetoacetate hydrolase (FAH). A patient showing few of the symptoms associated with the disease, was found to be a compound heterozygote for a splice mutation, IVS6-1g->t, and a putative missense mutation, Q279R. Analysis of FAH expression in liver sections obtained after resection for hepatocellular carcinoma revealed a mosaic pattern of expression. No FAH was found in tumor regions while a healthy region contained enzyme-expressing nodules.
        
        
          Results
          Analysis of DNA from a FAH expressing region showed that the expression of the protein was due to correction of the Q279R mutation. RT-PCR was used to assess if Q279R RNA was produced in the liver cells and in fibroblasts from the patient. Normal mRNA was found in the liver region where the mutation had reverted while splicing intermediates were found in non-expressing regions suggesting that the Q279R mutation acted as a splicing mutation in vivo. Sequence of transcripts showed skipping of exon 8 alone or together with exon 9. Using minigenes in transfection assays, the Q279R mutation was shown to induce skipping of exon 9 when placed in a constitutive splicing environment.
        
        
          Conclusion
          These data suggest that the putative missense mutation Q279R in the FAH gene acts as a splicing mutation in vivo. Moreover FAH expression can be partially restored in certain liver cells as a result of a reversion of the Q279R mutation and expansion of the corrected cells.

Tags: fah-gene, fumarylacetoacetate-hydrolase, nih, splice-mutation, tyrosinemia-type-i
Organization: U.S. Department of Health & Human Services
Teens in Foster Care Are Less Likely to Talk with Parent or Guardian about the Dangers of Substance Use (2002 to 2012 NSDUH)

This spotlight uses 2002 to 2012 National Survey on Drug Use and Health (NSDUH) to assess receipt of substance use prevention messages by youth aged 12 to 17 by whether the youth lives with foster parents, biological parents, or adoptive parents.

Tags: adolescent-health, foster-care, parent-communication, samhsa, substance-use-prevention
Organization: U.S. Department of Health & Human Services
Adenoviral gene transfer of angiostatic ATF-BPTI inhibits tumour growth

Background
          The outgrowth of new vessels – angiogenesis – in the tumour mass is considered to be a limiting factor of tumour growth. To inhibit the matrix lysis that is part of the tumour angiogenesis, we employed the chimeric protein mhATF-BPTI, composed of the receptor binding part of the urokinase (ATF) linked to an inhibitor of plasmin (BPTI).
        
        
          Methods
          For delivery, recombinant adenovirus encoding the transgene of interest was injected intravenously or locally into the tumour. The anti tumour effect of this compound was compared to that of human endostatin and of mhATF alone in two different rat bronchial carcinomas growing either as subcutaneous implants or as metastases.
        
        
          Results
          Significant inhibition of the tumour growth and decrease of the number of lung metastasis was achieved when the concentration of mhATF-BPTI at the tumour site was above 400 of ng / g tissue. This concentration could be achieved via production by the liver, only if permissive to the recombinant adenovirus. When the tumour cells could be transduced, local delivery of the vector was enough to obtain a response. In the case of metastasis, the capacity of the lung tissue to concentrate the encoded protein was essential to reach the required therapeutic levels. Further, endostatin or mhATF could not reproduce the effects of mhATF-BPTI, at similar concentrations (mhATF) and even at 10-fold higher concentration (endostatin).
        
        
          Conclusion
          The ATF-BPTI was shown to inhibit tumour growth of different rat lung tumours when critical concentration was reached. In these tumour models, endostatin or ATF induce almost no tumour response.

Tags: adenoviral-gene-transfer, angiogenesis-inhibition, atf-bpti, nih, tumor-growth
Organization: U.S. Department of Health & Human Services
Compound 525509: 7-Methyl-4-thiaoctane

Chemical compound data from PubChem database. IUPAC Name: 3-methyl-1-propylsulfanylbutane. Molecular Formula: C8H18S. Molecular Weight: 146.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Table 3. Marijuana Use in the Past Month among Persons Aged 12 or Older, by State and Substate Regions: Percentages, Annual Averages Based on 2010, 2011, and 2012 NSDUHs

Table 3. Marijuana Use in the Past Month among Persons Aged 12 or Older, by State and Substate Regions: Percentages, Annual Averages Based on 2010, 2011, and 2012 NSDUHs

Tags: adolescent-substance-use, marijuana-use, nsduh-data, samhsa, substate-data
Organization: U.S. Department of Health & Human Services
Boston: Drug-Related Emergency Department Visits, 2004-2011 - Adverse Reactions

Excel file with estimates, rates, relative standard errors, trends and confidence intervals, covering 2004-2011 for emergency department visits involving adverse reactions in the Boston metropolitan area. It includes ED visits in which an adverse health consequence (e.g., side effects or an allergic reaction) resulted when taking prescription drugs, over-the-counter medications, or dietary supplements as prescribed or recommended.  This analytic category does not include drug misuse or abuse.File includes data for over 500 drugs, including illicit drugs, prescription and over-the-counter medications, dietary supplements, inhalants and alcohol.  Includes total visits, gender, age group, race/ethnicity, outcome of visit, drug combinations, number of drugs involved in visit, drug frequency, and drugs confirmed by toxicology.Additional detail is provided for illicit drugs, psychotherapeutic drugs, central nervous system (CNS) drugs, respiratory drugs and cardiovascular drugs.

Tags: adverse-drug-events, drug-side-effects, emergency-department-visits, prescription-drugs, samhsa
Organization: U.S. Department of Health & Human Services
Fine mapping in tomato using microsynteny with the

The Arabidopsis thaliana genome sequence provides a catalog of reference genes applicable to comparative microsynteny analysis of other species, facilitating map-based cloning in economically important crops. Such an analysis was applied to the tomato expressed sequence tag (EST) database to expedite high-resolution mapping of the Diageotropica gene within the distal end of chromosome 1 in tomato.

Tags: arabidopsis-thaliana, diageotropica-gene, microsynteny-mapping, nih, tomato-genetics
Organization: U.S. Department of Health & Human Services
The diagnostic value of liver biopsy

Background
          Since the introduction of molecular diagnostic tools such as markers for hepatitis C and different autoimmune diseases, liver biopsy is thought to be useful mainly for staging but not for diagnostic purposes. The aim was to review the liver biopsies for 5 years after introduction of testing for hepatitis C, in order to evaluate what diagnostic insights – if any – remain after serologic testing.
        
        
          Methods
          Retrospective review of all liver biopsies performed between 1.1.1995 and 31.12.1999 at an academic outpatient hepatology department. The diagnoses suspected in the biopsy note were compared with the final diagnosis arrived at during a joint meeting with the responsible clinicians and a hepatopathologist.
        
        
          Results
          In 365 patients, 411 diagnoses were carried out before biopsy. 84.4 % were confirmed by biopsy but in 8.8 %, 6.8 % and 10.5 % the diagnosis was specified, changed or a diagnosis added, respectively. Additional diagnoses of clinical relevance were unrecognized biliary obstruction and additional alcoholic liver disease in patients with chronic hepatitis C. Liver biopsy led to change in management for 12.1 % of patients.
        
        
          Conclusion
          Even in the era of advanced virological, immunological and molecular genetic testing, liver biopsy remains a useful diagnostic tool. The yield is particularly high in marker negative patients but also in patients with a clear-cut prebiopsy diagnosis, liver biopsy can lead to changes in patient management.

Tags: diagnostic-testing, hepatitis-c, liver-biopsy, liver-disease, nih
Organization: U.S. Department of Health & Human Services
Prescription Opioid Use, Misuse, and Use Disorders in U.S. Adults: 2015 National Survey on Drug Use and Health

This study will examine the associations between motivations for misuse of prescription medications and sociodemographic factors, SUD, MDE, mental illness, and suicidal ideation.Prescription Opioid Use, Misuse, and Use Disorders in U.S. Adults: 2015 National Survey on Drug Use and Health(link is external)

Tags: nsduh-2015, opioid-misuse, prescription-opioids, samhsa, substance-use-disorder
Organization: U.S. Department of Health & Human Services
Foster Care: A Path to Reunification – Part 2

This Child Welfare Information Gateway Podcast is available on Apple Podcasts
  
  

, GooglePlay
  
  

, Spotify
  
  

, Stitcher
  
  

, SoundCloud
  
  

, and the Child Welfare Information Gateway
  
  

 website. Subscribe to receive new episodes as they are released.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: care, child, foster, podcast, reunification
Organization: U.S. Department of Health & Human Services
Search for intracranial aneurysm susceptibility gene(s) using Finnish families

Background
          Cerebrovascular disease is the third leading cause of death in the United States, and about one-fourth of cerebrovascular deaths are attributed to ruptured intracranial aneurysms (IA). Epidemiological evidence suggests that IAs cluster in families, and are therefore probably genetic. Identification of individuals at risk for developing IAs by genetic tests will allow concentration of diagnostic imaging on high-risk individuals. We used model-free linkage analysis based on allele sharing with a two-stage design for a genome-wide scan to identify chromosomal regions that may harbor IA loci.
        
        
          Methods
          We previously estimated sibling relative risk in the Finnish population at between 9 and 16, and proceeded with a genome-wide scan for loci predisposing to IA. In 85 Finnish families with two or more affected members, 48 affected sibling pairs (ASPs) were available for our genetic study. Power calculations indicated that 48 ASPs were adequate to identify chromosomal regions likely to harbor predisposing genes and that a liberal stage I lod score threshold of 0.8 provided a reasonable balance between detection of false positive regions and failure to detect real loci with moderate effect.
        
        
          Results
          Seven chromosomal regions exceeded the stage I lod score threshold of 0.8 and five exceeded 1.0. The most significant region, on chromosome 19q, had a maximum multipoint lod score (MLS) of 2.6.
        
        
          Conclusions
          Our study provides evidence for the locations of genes predisposing to IA. Further studies are necessary to elucidate the genes and their role in the pathophysiology of IA, and to design genetic tests.

Tags: finnish-families, genetic-susceptibility, intracranial-aneurysm, linkage-analysis, nih
Organization: U.S. Department of Health & Human Services
Compound 525045: N-(3,4-dichlorophenyl)pentanamide

Chemical compound data from PubChem database. IUPAC Name: N-(3,4-dichlorophenyl)pentanamide. Molecular Formula: C11H13Cl2NO. Molecular Weight: 246.13. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services