AndreaBozzo/ceres-open-data-index huggingface dataset:
Drug interaction: Omeprazole and Phenprocoumon

Background
          Oral anticoagulants like the coumarin derivatives are characterised by a particularly narrow therapeutic range. Any interfering co-medication can pose a challenge to establishing a stable anticoagulant dosage regimen and thus present a serious risk for the patient. Here we describe two cases of patients on anticoagulant therapy that suggest possible drug interactions between phenprocoumon and the proton pump inhibitor omeprazole.
        
        
          Results
          In both patients, the International Normalised Ratio (INR) increased beyond the therapeutic range after they were given omeprazole for the treatment of gastrointestinal symptoms. The INR returned to therapeutic levels after the phenprocoumon dose was reduced (Case 1) and omeprazole discontinued (Case 2).
        
        
          Conclusions
          The increased anticoagulant activity of phenprocoumon observed in the two described cases and the known interaction potential of omeprazole suggest that the clearance of phenprocoumon may have been reduced due to competitive inhibition of its degradation by omeprazole. Drug interactions may be one of the reasons for the difficulties encountered with some patients in establishing a stable anticoagulant therapy. Physicians should carefully review any concurrently used medication and if possible opt for drugs with a low interaction potential.

Tags: drug-interaction, inr-increase, nih, omeprazole, phenprocoumon
Organization: U.S. Department of Health & Human Services
Compound 525553: Benzylidene-(4-ethoxyphenyl)-amine

Chemical compound data from PubChem database. IUPAC Name: N-(4-ethoxyphenyl)-1-phenylmethanimine. Molecular Formula: C15H15NO. Molecular Weight: 225.28. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
AFCARS Report #11

This report provides preliminary estimaes of AFCARS data for FY 2004. Preliminary reports of AFCARS data include data received by September 30 for the report period ending March 31 and by March 31 for the report period ending September 30. This generally encompasses the required data submissions and submission of corrected data by States to avoid possible financial penalties.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: assessment, child, data, policy, reporting
Organization: U.S. Department of Health & Human Services
2012 Uniform Reporting System (URS) Tables for New York

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2012. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-data, community-mental-health, mental-health-services, noms-measures, samhsa
Organization: U.S. Department of Health & Human Services
Adoption Data 2011

This page includes reports on state-specific adoption statistics for fiscal year 2011.

Receiving Adoption Subsidy: 10/1/2010 - 9/30/2011
Adoptive Family Structure: 10/1/2010 - 9/30/2011
Age at Adoption Finalization: 10/1/2010 - 9/30/2011
Prior Relationship of Adoptive Parent(s) to Child: 10/1/2010 - 9/30/2011
Race/Ethnicity of Public Agency Children Adopted: 10/1/2010 - 9/30/2011
Sex of Public Agency Children Adopted: 10/1/2010 - 9/30/2011
Child is Identified as a Special Needs Adoption: 10/1/2010 - 9/30/2011
Time between Termination of Parental Rights (TPR) and Adoption Finalization: 10/1/2010 - 9/30/2011

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: adoption, child, data, fiscal, policy
Organization: U.S. Department of Health & Human Services
Characterisation and expression of a PP1 serine/threonine protein phosphatase (PfPP1) from the malaria parasite,

Background
          Reversible protein phosphorylation is relatively unexplored in the intracellular protozoa of the Apicomplexa family that includes the genus Plasmodium, to which belong the causative agents of malaria. Members of the PP1 family represent the most highly conserved protein phosphatase sequences in phylogeny and play essential regulatory roles in various cellular pathways. Previous evidence suggested a PP1-like activity in Plasmodium falciparum, not yet identified at the molecular level.
        
        
          Results
          We have identified a PP1 catalytic subunit from P. falciparum and named it PfPP1. The predicted primary structure of the 304-amino acid long protein was highly similar to PP1 sequences of other species, and showed conservation of all the signature motifs. The purified recombinant protein exhibited potent phosphatase activity in vitro. Its sensitivity to specific phosphatase inhibitors was characteristic of the PP1 class. The authenticity of the PfPP1 cDNA was further confirmed by mutational analysis of strategic amino acid residues important in catalysis. The protein was expressed in all erythrocytic stages of the parasite. Abrogation of PP1 expression by synthetic short interfering RNA (siRNA) led to inhibition of parasite DNA synthesis.
        
        
          Conclusions
          The high sequence similarity of PfPP1 with other PP1 members suggests conservation of function. Phenotypic gene knockdown studies using siRNA confirmed its essential role in the parasite. Detailed studies of PfPP1 and its regulation may unravel the role of reversible protein phosphorylation in the signalling pathways of the parasite, including glucose metabolism and parasitic cell division. The use of siRNA could be an important tool in the functional analysis of Apicomplexan genes.

Tags: malaria-research, nih, pfpp1-protein, plasmodium-falciparum, protein-phosphatase
Organization: U.S. Department of Health & Human Services
Hawaii (HI)

This report presents estimates for measures of substance use and mental health based on the combined 2010 and 2011 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for Hawaii for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: mental-health, national-survey, samhsa, substance-use, suicidal-ideation
Organization: U.S. Department of Health & Human Services
Meta-analysis: Neither quick nor easy

Background
          Meta-analysis is often considered to be a simple way to summarize the existing literature. In this paper we describe how a meta-analysis resembles a conventional study, requiring a written protocol with design elements that parallel those of a record review.
        
        
          Methods
          The paper provides a structure for creating a meta-analysis protocol. Some guidelines for measurement of the quality of papers are given. A brief overview of statistical considerations is included. Four papers are reviewed as examples. The examples generally followed the guidelines we specify in reporting the studies and results, but in some of the papers there was insufficient information on the meta-analysis process.
        
        
          Conclusions
          Meta-analysis can be a very useful method to summarize data across many studies, but it requires careful thought, planning and implementation.

Tags: literature-review, meta-analysis, nih, research-synthesis, systematic-review
Organization: U.S. Department of Health & Human Services
National Youth in Transition Database Data Briefs

These short reports summarize findings from State NYTD data submissions compiled by the Children's Bureau.

National Youth in Transition Database Data Brief #1National Youth in Transition Database Data Brief #2National Youth in Transition Database Data Brief #3National Youth in Transition Database Data Brief #4 (PDF)National Youth in Transition Database Data Brief #5National Youth in Transition Database Data Brief #6National Youth in Transition Database Data Brief #7

National Youth in Transition Services and Outcomes Reports

These reports highlight information on key elements from State NYTD data submissions compiled by the Children’s Bureau.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: assessment, child, policy, reporting, scope
Organization: U.S. Department of Health & Human Services
San Francisco – SF Div: Drug-Related Emergency Department Visits, 2004-2011 - Underage Drinking

Excel file with estimates, rates, relative standard errors, trends and confidence intervals for all drug-related emergency department (ED) visits involving underage drinking in the San Francisco division of the San Francisco metropolitan area, covering 2004-2011.  Underage drinking includes ED visits that involve alcohol use (alone or with other drugs) for patients under the age of 21.

Tags: alcohol-related-visits, emergency-department, samhsa, san-francisco, underage-drinking
Organization: U.S. Department of Health & Human Services
2018 Uniform Reporting System (URS) Table for South Dakota

This is the 2018 Uniform Reporting System (URS) Output Tables for South Dakota. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: mental-health-services, national-outcome-measures, samhsa, south-dakota, substance-abuse-treatment
Organization: U.S. Department of Health & Human Services
2017 National Directory of Mental Health Treatment Facilities

The National Directory of Mental Health Treatment Facilities - 2017 is a listing of federal, state, and local government facilities and private facilities that provide mental health treatment services. It includes treatment facilities that responded to the 2016 National Mental Health Services Survey (N-MHSS). The information about each facility that appears in this Directory was provided by that facility in response to the 2016 N-MHSS. The N-MHSS is conducted annually by the Substance Abuse and Mental Health Services Administration (SAMHSA).The Directory is ordered alphabetically by state, by city within each state, and by facility name within each city. Each facility listing includes codes that represent the services offered and other features of the facility, including codes that indicate services for hearing impaired and non-English-speaking clients. Codes are defined in a key shown on pages v-vii. Because the services offered by a particular facility may change over time, it is always a good idea to verify the information in this Directory when contacting a facility.

Tags: behavioral-health, facility-directory, mental-health-facilities, samhsa, treatment-services
Organization: U.S. Department of Health & Human Services
Manchester-Nashua, NH

This report presents combined 2005 to 2010 National Survey on Drug Use and Health (NSDUH) results for those aged 12 or older in the Manchester-Nashua, NH metro area. The report includes estimates of substance use disorder, major depressive episode, illicit drug use, marijuana use, cigarette use, binge alcohol use, and the nonmedical use of prescription-type pain relievers. Results are provided for the Manchester-Nashua metro area, New Hampshire, and the U.S. overall.

Tags: major-depressive-episode, nh-metro-area, nsduh-data, samhsa, substance-use-disorder
Organization: U.S. Department of Health & Human Services
One-Third of Young Adults with Any Mental Illness Received Mental Health Services in the Past Year

This spotlight uses 2014 National Survey on Drug Use and Health (NSDUH) to examine mental health service use among young adults aged 18 to 25 with any mental illness.

Tags: mental-health-services, mental-illness, samhsa, service-utilization, young-adults
Organization: U.S. Department of Health & Human Services
Blood substitutes Artificial oxygen carriers: perfluorocarbon		  emulsions

Perfluorocarbon emulsions are being clinically evaluated as			 artificial oxygen carriers to reduce allogeneic blood transfusions or to			 improve tissue oxygenation. Perfluorocarbon emulsions are efficacious in animal			 experiments, and in humans they are well tolerated and at least as successful			 to reverse physiologic transfusion triggers than autologous blood.			 Perfluorocarbon emulsions may be used in the future in the concept of augmented			 acute normovolaemic haemodilution. In this concept relatively low preoperative			 haemoglobin levels are targeted during preoperative normovolaemic haemodilution			 and a perfluorocarbon emulsion is given to augment oxygen delivery during			 surgery when low endogenous haemoglobin levels are expected. The autologous			 blood is subsequently retransfused in the postoperative period when the			 patient's oxygenation is provided primarily by the endogenous			 haemoglobin. Additional uses of perfluorocarbon emulsions will include			 treatments of diseases with compromised tissue oxygenation such as cerebral or			 myocardial ischaemia, air embolism and emergency or trauma surgery as long as			 no allogeneic blood is available.

Tags: blood-substitutes, blood-transfusion, nih, oxygen-carriers, perfluorocarbon-emulsions
Organization: U.S. Department of Health & Human Services
Prophylactic cranial irradiation in small cell lung cancer: a systematic review of the literature with meta-analysis

Purpose
          A systematic review of the literature was carried out to determine the role of prophylactic cranial irradiation (PCI) in small cell lung cancer (SCLC) .
        
        
          Methods
          To be eligible, full published trials needed to deal with SCLC and to have randomly assigned patients to receive PCI or not. Trials quality was assessed by two scores (Chalmers and ELCWP).
        
        
          Results
          Twelve randomised trials (1547 patients) were found to be eligible. Five evaluated the role of PCI in SCLC patients who had complete response (CR) after chemotherapy. Brain CT scan was done in the work-up in five studies and brain scintigraphy in six. Chalmers and ELCWP scores are well correlated (p < 0.001), with respective median scores of 32.6 and 38.8 %. This meta-analysis based on the available published data reveals a decrease of brain metastases incidence (hazard ratio (HR): 0.48; 95 % confidence interval (CI): 0.39 - 0.60) for all the studies and an improvement of survival (HR: 0.82; 95 % CI: 0.71 - 0.96) in patients in CR in favour of the PCI arm. Unfortunately, long-term neurotoxicity was not adequately described .
        
        
          Conclusions
          PCI decreases brain metastases incidence and improves survival in CR SCLC patients but these effects were obtained in patients who had no systematic neuropsychological and brain imagery assessments. The long-term toxicity has not been prospectively evaluated. If PCI can be recommended in patients with SCLC and CR documented by a work-up including brain CT scan, data are lacking to generalise its use to any CR situations.

Tags: brain-metastases, nih, prophylactic-cranial-irradiation, small-cell-lung-cancer, systematic-review
Organization: U.S. Department of Health & Human Services
2011 CMHS Uniform Reporting System (URS) Output Tables for Kentucky

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2011. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, outcome-measures, samhsa, urs-data
Organization: U.S. Department of Health & Human Services
Kansas Intensive Permanency Project (KIPP) Permanency Innovations Initiative (PII) Grantee Profile

The University of Kansas, in partnership with the Kansas Department for Children and Families, and two private providers that comprise Kansas' statewide foster care network, is working to accelerate stable permanency for families of children with serious emotional disturbance (SED) by delivering intensive home-based parent training and support services shortly after children have been removed from their homes.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: care, foster, grant, policy, real
Organization: U.S. Department of Health & Human Services
Compound 528344: Benzoic acid, 5-chloro-2-hydroxy, TMS

Chemical compound data from PubChem database. IUPAC Name: trimethylsilyl 5-chloro-2-trimethylsilyloxybenzoate. Molecular Formula: C13H21ClO3Si2. Molecular Weight: 316.92. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2018 Mental Health Client-level Data (MH-CLD) Annual Report

This report presents results from the Mental Health Client-Level Data (MH-CLD) and Mental Health Treatment Episode Data Set (MH-TEDS) for individuals receiving mental health services from state mental health systems in 2018, as well as selected trends in data collected from such individuals between 2013 and 2018. The report provides information on mental health diagnoses, mental health treatment settings, and demographic and substance use characteristics of individuals in mental health treatment in facilities that reported to individual state administrative data systems.

Tags: mental-health-diagnosis, mental-health-services, mh-cld, mh-teds, samhsa
Organization: U.S. Department of Health & Human Services
Use of antihypertensive medications in pregnancy and the risk of adverse perinatal outcomes: McMaster Outcome Study of Hypertension In Pregnancy 2 (

Background
          Uncertainty remains about the potential harmful effects of antihypertensive therapy on the developing fetus, especially for beta-blockers (βb).
        
        
          Methods
          We prospectively enrolled all singleton women with a blood pressure ≥ 140/90 mm Hg during pregnancy. The main analysis included 1948 women with all forms of hypertension and compared the use of βb drugs, non-βb drugs or a combination of both, to no treatment. The primary study outcome was a composite of the diseases of prematurity, need for assisted ventilation for greater than 1 day, or perinatal death. A sub-group analysis evaluated the four treatment options among 583 singleton women with chronic hypertension before 20 weeks gestation.
        
        
          Results
          In the main analysis, no association was observed between βb use and the primary composite outcome [adjusted odds ratio (OR) 1.4, 95% CI 0.9–2.2], while an association was seen with non-βb therapy (OR 5.0, 95% CI 2.6–9.6) and combination therapy (OR 2.9, 95% CI 1.8–4.7). In the sub-group of 583 women with hypertension before 20 weeks, use of a non-βb drug (OR 4.9, 95% CI 1.7–14.2) or combination therapy (OR 2.9. 95% CI 1.1–7.7) was significantly associated with the primary composite outcome, while βb monotherapy was not (OR 1.4, 95% CI 0.6–3.4).
        
        
          Conclusions
          Maternal use of antihypertensive medications other than βbs was associated with both major perinatal morbidity and mortality, while βb monotherapy was not. The combined use of βb and non-βb medications demonstrated the strongest association. Before definitive conclusions can be drawn, a large multicentre randomized controlled trial is needed to address the issues of both maternal efficacy and fetal safety with the use of one or more antihypertensive agents in pregnancy.

Tags: antihypertensive-medications, hypertension-pregnancy, nih, perinatal-mortality, pregnancy-outcomes
Organization: U.S. Department of Health & Human Services
Treatment Episode Data Set (TEDS): 2017 Admissions to and Discharges from Publicly-Funded Substance Use Treatment

This report presents national- and state-level data from the Treatment Episode Data Set (TEDS) for admissions and discharges occurring in 2017, and trend data from 2007 to 2017. It summarizes demographic information and the characteristics and outcomes of treatment for alcohol and/or drug use among clients aged 12 years and older in facilities that report to individual state administrative data systems. Data include records for treatment admissions and discharges that were received and processed through November 21, 2018. TEDS records do not represent individuals; rather, each record represents a treatment episode. Thus, an individual admitted to treatment twice within a calendar year is counted as two admissions. Similarly, discharges during the year, regardless of when the admission occurred, are counted. TEDS does not include all substance use treatments. It includes treatment admissions and discharges at facilities that are licensed or certified by a state substance abuse agency to provide care for people with a substance use disorder (or facilities that are administratively tracked for other reasons). In general, facilities reporting TEDS data are those that receive state alcohol and/or drug agency funds (including federal block grant funds) for the provision of alcohol and/or drug treatment services. Additional information on the history and methodology of TEDS and this report, as well as important issues related to state data collection systems, are available in Appendix A.

Tags: publicly-funded-treatment, samhsa, substance-use-treatment, teds-admissions, teds-discharges
Organization: U.S. Department of Health & Human Services
Compound 525362: 2,3-Dimethyl-4,5-dithiahexane

Chemical compound data from PubChem database. IUPAC Name: 2-methyl-3-(methyldisulfanyl)butane. Molecular Formula: C6H14S2. Molecular Weight: 150.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services