AndreaBozzo/ceres-open-data-index huggingface dataset:
Compound 529180: 1-Pentanol, DMTBS

Chemical compound data from PubChem database. IUPAC Name: tert-butyl-dimethyl-pentoxysilane. Molecular Formula: C11H26OSi. Molecular Weight: 202.41. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 527306: 2,4a,8,8-tetramethyl-1a,3,4,5,6,7-hexahydro-1H-cyclopropa[j]naphthalen-2-ol

Chemical compound data from PubChem database. IUPAC Name: 2,4a,8,8-tetramethyl-1a,3,4,5,6,7-hexahydro-1H-cyclopropa[j]naphthalen-2-ol. Molecular Formula: C15H26O. Molecular Weight: 222.37. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
The genetics of chronic obstructive pulmonary disease

Chronic obstructive pulmonary disease (COPD) is a significant cause of global morbidity and mortality. Previous studies have shown that COPD aggregates in families, suggesting a genetic predisposition to airflow obstruction. Many candidate genes have been assessed, but the data are often conflicting. We review the genetic factors that predispose smokers to COPD and highlight the future role of genomic scans in identifying novel susceptibility genes.

Tags: airflow-obstruction, copd-genetics, genetic-predisposition, nih, pulmonary-disease
Organization: U.S. Department of Health & Human Services
Compound 526799: 4-Hydroxy-arachidic, gamma-lactone

Chemical compound data from PubChem database. IUPAC Name: 5-hexadecyloxolan-2-one. Molecular Formula: C20H38O2. Molecular Weight: 310.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 528508: Hexadecane, 3-pentyl

Chemical compound data from PubChem database. IUPAC Name: 6-ethylnonadecane. Molecular Formula: C21H44. Molecular Weight: 296.6. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Cisapride decreases gastric content aspiration in mechanically
		  ventilated patients

Objective:
          To determine the effect of the prokinetic agent cisapride in the
				prevention of aspiration of gastric contents.
        
        
          Design:
          A prospective randomized two-period crossover study.
        
        
          Setting:
          Fourteen-bed polyvalent intensive care unit in a University
				Hospital.
        
        
          Patients:
          Eighteen intubated, mechanically ventilated patients who were
				seated in a semirecumbent position were studied.
        
        
          Method:
          Tc-99 m sulfur colloid (80 megabecquerels) was administered via
				nasogastric tube on 2 consecutive days. Patients randomly received cisapride
				(10 mg, via nasogastric tube) one day and a placebo the other. Bronchial
				secretions were obtained before and for 5 consecutive h after Tc-99 m
				administration. The radioactivity was measured in a standard amount (1ml) of
				bronchial fluid using a gamma counter and expressed as counts per min (cpm)
				after correction for decay.
        
        
          Results:
          Sixteen out of 18 (88%) patients had increased radioactivity in
				bronchial secretions. The radioactivity increased over time both with and
				without cisapride, although it was lower in patients receiving cisapride than
				in those receiving a placebo. The cumulative bronchial secretion radioactivity
				obtained when patients received cisapride was significantly lower than when
				patients received a placebo: 7540 ± 5330 and 21965 ± 16080 cpm,
				respectively (P <0.05).
        
        
          Conclusion:
          Our results suggest that aspiration of gastric contents exists
				even in patients who are kept in a semirecumbent position. Moreover, cisapride
				decreases the amount of gastric contents aspiration in intubated and
				mechanically ventilated patients and may play a role in the prevention of
				ventilator associated pneumonia. Cisapride, even with the patient in the
				semirecumbent position, did not completely prevent gastric content
				aspiration.

Tags: aspiration-prevention, cisapride-treatment, gastric-content, mechanical-ventilation, nih
Organization: U.S. Department of Health & Human Services
Compound 527333: 2-(2,3-Dimethylphenyl)adamantane

Chemical compound data from PubChem database. IUPAC Name: 2-(2,3-dimethylphenyl)adamantane. Molecular Formula: C18H24. Molecular Weight: 240.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2017 Uniform Reporting System (URS) Table for Texas

This is the 2017 Uniform Reporting System (URS) Output Tables for Texas. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, outcome-measures, samhsa, texas-mental-health
Organization: U.S. Department of Health & Human Services
Interaction of the Yersinia pestis type III regulatory proteins LcrG and LcrV occurs at a hydrophobic interface: correction

Interaction of the Yersinia pestis type III regulatory proteins LcrG and LcrV occurs at a hydrophobic interface: correction

Tags: lcrg-lcrv-interaction, nih, protein-regulation, type-iii-secretion, yersinia-pestis
Organization: U.S. Department of Health & Human Services
Compound 525580: N,N-Dimethyl-N'-(3-methylphenyl)-p-methoxybenzamidine

Chemical compound data from PubChem database. IUPAC Name: 4-methoxy-N,N-dimethyl-N'-(3-methylphenyl)benzenecarboximidamide. Molecular Formula: C17H20N2O. Molecular Weight: 268.35. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 525656: p-Bromobenzylidene-(3-methoxyphenyl)-amine

Chemical compound data from PubChem database. IUPAC Name: 1-(4-bromophenyl)-N-(3-methoxyphenyl)methanimine. Molecular Formula: C14H12BrNO. Molecular Weight: 290.15. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Management of obstetric anal sphincter injury: a systematic review & national practice survey

Background
          We aim to establish the evidence base for the recognition and management of obstetric anal sphincter injury (OASI) and to compare this with current practice amongst UK obstetricians and coloproctologists.
        
        
          Methods
          A systematic review of the literature and a postal questionnaire survey of consultant obstetricians, trainee obstetricians and consultant coloproctologists was carried out.
        
        
          Results
          We found a wide variation in experience of repairing acute anal sphincter injury. The group with largest experience were consultant obstetricians (46.5% undertaking ≥ 5 repairs/year), whilst only 10% of responding colorectal surgeons had similar levels of experience (p < 0.001). There was extensive misunderstanding in terms of the definition of obstetric anal sphincter injuries. Overall, trainees had a greater knowledge of the correct classification (p < 0.01). Observational studies suggest that a new 'overlap' repair using PDS sutures with antibiotic cover gives better functional results. However, our literature search found only one randomised controlled trial (RCT) on the technique of repair of OASI, which showed no difference in incidence of anal incontinence at three months. Despite this, there was a wide variation in practice, with 337(50%) consultants, 82 (55%) trainees and 80 (89%) coloproctologists already using the 'overlap' method for repair of a torn EAS (p < 0.001). Although over 50% of colorectal surgeons would undertake long-term follow-up of their patients, this was the practice of less than 10% of obstetricians (p < 0.001). Whilst over 70% of coloproctologists would recommend an elective caesarean section in a subsequent pregnancy, only 22% of obstetric consultants and 14% of trainees (p < 0.001).
        
        
          Conclusion
          An agreed classification of OASI, development of national guidelines, formalised training, multidisciplinary management and further definitive research is strongly recommended.

Tags: national-practice-survey, nih, oasi-management, obstetric-anal-sphincter-injury, systematic-review
Organization: U.S. Department of Health & Human Services
Dietary antioxidants protect gut epithelial cells from oxidant-induced apoptosis

Background
          The potential of ascorbic acid and two botanical decoctions, green tea and cat's claw, to limit cell death in response to oxidants were evaluated in vitro.
        
        
          Methods
          Cultured human gastric epithelial cells (AGS) or murine small intestinal epithelial cells (IEC-18) were exposed to oxidants – DPPH (3 μM), H2O2 (50 μM), peroxynitrite (300 μM) – followed by incubation for 24 hours, with antioxidants (10 μg/ml) administered as a 1 hour pretreatment. Cell number (MTT assay) and death via apoptosis or necrosis (ELISA, LDH release) was determined. The direct interactions between antioxidants and DPPH (100 μM) or H2O2 (50 μM) were evaluated by spectroscopy.
        
        
          Results
          The decoctions did not interact with H2O2, but quenched DPPH although less effectively than vitamin C. In contrast, vitamin C was significantly less effective in protecting human gastric epithelial cells (AGS) from apoptosis induced by DPPH, peroxynitrite and H2O2 (P < 0.001). Green tea and cat's claw were equally protective against peroxynitrite and H2O2, but green tea was more effective than cat's claw in reducing DPPH-induced apoptosis (P < 0.01). Necrotic cell death was marginally evident at these low concentrations of peroxynitrite and H2O2, and was attenuated both by cat's claw and green tea (P < 0.01). In IEC-18 cells, all antioxidants were equally effective as anti-apoptotic agents.
        
        
          Conclusions
          These results indicate that dietary antioxidants can limit epithelial cell death in response to oxidant stress. In the case of green tea and cat's claw, the cytoprotective response exceed their inherent ability to interact with the injurious oxidant, suggestive of actions on intracellular pathways regulating cell death.

Tags: antioxidant-effects, apoptosis, epithelial-cells, nih, oxidative-stress
Organization: U.S. Department of Health & Human Services
National trends in substance use and use disorders among youth

This analysis will examine the overlap of marijuana, tobacco and alcohol use among youth in the US. DuPont had requested this analysis, Han rightly suggested an article with DuPont included as author.National trends in substance use and use disorders among youth(link is external)

Tags: alcohol, co-occurring-disorders, marijuana-tobacco-alcohol, samhsa, youth-substance-use
Organization: U.S. Department of Health & Human Services
Patient and health service delay in the diagnosis of pulmonary tuberculosis in Ethiopia

Background
          Delay in the diagnosis of tuberculosis may worsen the disease, increase the risk of death and enhance tuberculosis transmission in the community. This study aims to determine the length of delay between the onset of symptoms and patients first visit to health care (patient delay), and the length of delay between health care visit and the diagnosis of tuberculosis (health service delay).
        
        
          Methods
          A cross sectional survey that included all the public health centres was conducted in Addis Ababa from August 1 to December 31 1998. Patients were interviewed on the same day of diagnosis using structured questionnaire.
        
        
          Results
          700 pulmonary TB patients were studied. The median patient delay was 60 days and mean 78.2 days. There was no significant difference in socio-demographic factors in those who delayed and came earlier among smear positives. However, there was a significant difference in distance from home to health institute and knowledge about TB treatment among the smear negatives. The health service delay was low (median 6 days; mean 9.5 days) delay was significantly lower in smear positives compared to smear negatives. Longer health service delay (delay more than 15 days) was associated with far distance.
        
        
          Conclusions
          The time before diagnosis in TB patients was long and appears to be associated with patient inadequate knowledge of TB treatment and distance to the health centre. Further decentralization of TB services, the use of some components of active case finding, and raising public awareness of the disease to increase service utilization are recommended.

Tags: diagnostic-delay, ethiopia, nih, patient-delay, pulmonary-tuberculosis
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Region 9, Volume 7

Explore state and regional data for HHS Region 9 with this user-friendly behavioral health report. It uses data from the 2021-2022 National Surveys on Drug Use and Health (NSDUH). The topics addressed in this report include substance use, substance use disorders, and mental health. Selected estimates are provided for adolescents aged 12 to 17, underage people aged 12 to 20, adults aged 18 or older, and the general population aged 12 or older. Statistical tests compare population percentages of (1) HHS region versus national estimates, (2) state versus national estimates, and (3) state versus HHS region estimates.

Tags: behavioral-health, mental-health, nsduh-data, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Child and Family Services Reviews Key Children's Bureau and Federal Contractor Staff

The Child and Family Services Reviews (CFSRs) are administered by the Children's Bureau, U.S. Department of Health and Human Services. The following is contact information for the Children's Bureau CFSR leadership and data team, and the federal contractors who provide support to the CFSRs.

Children's Bureau

1250 Maryland Avenue, S.W
8th Floor
Washington, DC 20024
(202) 205-8618

Children's Bureau Central and Regional Office Staff

Contact information for Children's Bureau Central and Regional Office staff can be found at /oro/about/contact.

Review Leadership

Angela Adams
Bob Baptista
Misty Carlyle
Yolanda Fripp
James Gregory
Jennifer Miller Haight
Angela Ivey
Elizabeth Jones-Ferguson
Sylvia Kim
Richard Longoria
Danielle McConaga
Allison McDowell
Linda Mitchell
Beth Pierce

Data Team

Telisa Burt
Malcolm Hale
John Hargrove
Steven Lao
Sharon Newburg-Rinn
Roger Stanton
Tammy White

Child Welfare Reviews Project
5515 Security Lane, Suite 800
North Bethesda, MD 20852-5007
(301) 495-1080

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: assessment, child, policy, scope, social
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: State Barometers, 2015

This is a behavioral health report for each of the 50 States and District of Columbia. Each state report utilizes data from the National Survey on Drug Use and Health (NSDUH), and the Uniform Reporting System. The topics addressed in the report include youth substance use, youth mental health and treatment, substance use and substance use treatment.

Tags: behavioral-health, samhsa, state-level-data, substance-use, youth-mental-health
Organization: U.S. Department of Health & Human Services
Debate: Transfusing to normal hemoglobin levels improves outcome

Red cells are uniquely designed to transport oxygen and facilitate oxygen uptake by systemic tissues. Blood transfusions are thus logical therapeutic choices in patients who exhibit signs of oxygen debt. A small number of studies that have addressed patients with metabolic or physiologic signs of oxygen debt or regional ischaemia suggest that liberal blood transfusion strategies improve outcome. Therefore, armed with an understanding of the variety of clinical presentations characterising oxygen debt, as well as an appreciation of the risks involved, blood transfusions should be considered in all critically ill patients. This includes the consideration of liberalized hemoglobin triggers and hemoglobin thresholds in normal ranges.

Tags: blood-transfusion, hemoglobin-levels, ischemia-treatment, nih, oxygen-debt
Organization: U.S. Department of Health & Human Services
A hierarchical statistical model for estimating population properties of quantitative genes

Background
          Earlier methods for detecting major genes responsible for a quantitative trait rely critically upon a well-structured pedigree in which the segregation pattern of genes exactly follow Mendelian inheritance laws. However, for many outcrossing species, such pedigrees are not available and genes also display population properties.
        
        
          Results
          In this paper, a hierarchical statistical model is proposed to monitor the existence of a major gene based on its segregation and transmission across two successive generations. The model is implemented with an EM algorithm to provide maximum likelihood estimates for genetic parameters of the major locus. This new method is successfully applied to identify an additive gene having a large effect on stem height growth of aspen trees. The estimates of population genetic parameters for this major gene can be generalized to the original breeding population from which the parents were sampled. A simulation study is presented to evaluate finite sample properties of the model.
        
        
          Conclusions
          A hierarchical model was derived for detecting major genes affecting a quantitative trait based on progeny tests of outcrossing species. The new model takes into account the population genetic properties of genes and is expected to enhance the accuracy, precision and power of gene detection.

Tags: em-algorithm, gene-mapping, nih, quantitative-trait-loci, statistical-genetics
Organization: U.S. Department of Health & Human Services
CBHSQ Data Brief: Peer services supported through State Targeted Response to the Opioid Crisis grants

This CBHSQ Data Brief presents findings from the evaluation of the State Targeted Response to the Opioid Crisis Grants (Opioid STR) that describe how funding was used to support peer services for people with or recovering from opioid use disorder (OUD).  The evaluation revealed that most Opioid STR grantees used funds to implement, expand, or enhance peer services. The peer services most commonly provided were coaching, mentoring, and providing information and referrals to relevant services.The Opioid STR was the predecessor of the State Opioid Response (SOR) grant program and informed its development. At the start of SOR, grantees were expected to provide an array of services based on needs identified in their STR strategic plan. SOR addresses the opioid overdose crisis by providing resources to states and territories for increasing access to FDA-approved medications for the treatment of opioid use disorder (MOUD), and for supporting the continuum of prevention, harm reduction, treatment, and recovery support services.

Tags: medication-assisted-treatment, opioid-use-disorder, peer-support-services, samhsa, state-targeted-response
Organization: U.S. Department of Health & Human Services
Compound 525543: 2-(((1,1-Dimethylethyl)dimethylsilyl)oxy)-3-(1-methylethyl)quinoxaline

Chemical compound data from PubChem database. IUPAC Name: tert-butyl-dimethyl-(3-propan-2-ylquinoxalin-2-yl)oxysilane. Molecular Formula: C17H26N2OSi. Molecular Weight: 302.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 525562: N,N-Dimethyl-N'-(3-bromophenyl)-p-methoxybenzamidine

Chemical compound data from PubChem database. IUPAC Name: N'-(3-bromophenyl)-4-methoxy-N,N-dimethylbenzenecarboximidamide. Molecular Formula: C16H17BrN2O. Molecular Weight: 333.22. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
High daily doses of benzodiazepines among Quebec seniors: prevalence and correlates

Background
          Use of high daily doses of benzodiazepines is generally contraindicated for seniors. While both patient and physician factors may influence the use of high daily doses, previous research on the effect of patient factors has been extremely limited. The objectives of this study were to determine the one year prevalence of use of high daily doses of benzodiazepines, and examine physician and patient correlates of such use among Quebec community-dwelling seniors.
        
        
          Methods
          Patient information for 1423 community-dwelling Quebec seniors who participated in the Canadian Study of Health and Aging was linked to provincial health insurance administrative data bases containing detailed information on prescriptions received and prescribers.
        
        
          Results
          The standardized one year period prevalence of use of high daily doses of benzodiazepines was 7.9%. Use of high daily doses was more frequent among younger seniors and those who had reported anxiety during the previous year. Patients without cognitive impairment were more likely to receive high dose prescriptions from general practitioners, while those with cognitive impairment were more likely to receive high dose prescriptions from specialists.
        
        
          Conclusion
          High dose prescribing appears to be related to both patient and physician factors.

Tags: benzodiazepine-use, elderly-health, nih, prescription-drug-use, quebec-health
Organization: U.S. Department of Health & Human Services
Table 23. Needing But Not Receiving Treatment for Alcohol Use in the Past Year among Persons Aged 12 or Older, by State and Substate Regions: Percentages, Annual Averages Based on 2010, 2011, and 2012 NSDUHs

Table 23. Needing But Not Receiving Treatment for Alcohol Use in the Past Year among Persons Aged 12 or Older, by State and Substate Regions: Percentages, Annual Averages Based on 2010, 2011, and 2012 NSDUHs

Tags: alcohol-use-disorder, nsduh-data, samhsa, substate-data, unmet-treatment-need
Organization: U.S. Department of Health & Human Services