AndreaBozzo/ceres-open-data-index huggingface dataset:
Association of MHC and rheumatoid arthritis: Association of RA with HLA-DR4 - the role of repertoire selection

Most patients with rheumatoid arthritis (RA) express HLA-DR4, HLA-DR1 or HLA-DR10. These alleles share a common amino acid motif in their third hypervariable regions: the shared epitope. In normals and patients with RA, HLA-DR genes exert a major influence on the CD4 αβ T-cell repertoire, as shown by studies of AV and BV gene usage and by BV BJ gene usage by peripheral blood CD4 αβ T-cells. However, the rheumatoid T-cell repertoire is not entirely under HLA-DR influence, as demonstrated by discrepancies in VB JB gene usage between identical twins discordant for RA and by contraction of the CD4 αβ T-cell repertoire in RA patients. Shared epitope positive HLA-DR alleles may shape the T-cell repertoire by presenting self peptides to CD4 T cells in the thymus. Peptides processed from HLA-DR molecules and encompassing the shared epitope may also be presented by HLA-DQ and select CD4 αβ T cells in the thymus. Thus, shared epitope-positive alleles impose a frame on the T-cell repertoire. This predisposing frame is further modified (by unknown factors) to obtain the contracted rheumatoid repertoire.

Tags: hla-dr4, nih, rheumatoid-arthritis, shared-epitope, t-cell-repertoire
Organization: U.S. Department of Health & Human Services
2022 Uniform Reporting System (URS) Table For Vermont

This is the 2022 Uniform Reporting System (URS) Output Tables for Vermont. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, national-outcome-measures, samhsa, vermont
Organization: U.S. Department of Health & Human Services
Compound 528360: 4-Ethyldihydro-2,6-dimethyl-4H-1,3,5-dithiazine

Chemical compound data from PubChem database. IUPAC Name: 4-ethyl-2,6-dimethyl-1,3,5-dithiazinane. Molecular Formula: C7H15NS2. Molecular Weight: 177.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Manipulation of prenatal hormones and dietary phytoestrogens during adulthood alter the sexually dimorphic expression of visual spatial memory

Background
          In learning and memory tasks, requiring visual spatial memory (VSM), males exhibit higher performance levels compared to females (a difference attributed to sex steroid hormonal influences). Based upon the results from our companion investigation, this study examined the influence of prenatal sex steroid hormone manipulations on VSM in adulthood, as assessed in the radial arm maze. Additionally, the influence of dietary soy phytoestrogens (i.e., the presence of high or low estrogen-like compounds present in the animal's diet) on VSM was examined in combination with the prenatal hormonal manipulations.
        
        
          Results
          Radial arm maze performance on a phytoestrogen-rich diet: 1) females treated prenatally with testosterone were masculinized and acquired/performed in a manner similar to control or oil-treated males and 2) males treated prenatally with an androgen receptor blocker (flutamide) were feminized and acquired/performed in a fashion typical of control or flutamide-treated females. When a diet change was initiated in adulthood, control phytoestrogen-rich fed females outperformed control females switched to a phytoestrogen-free diet. Whereas, in control males the opposite diet effect was identified. Furthermore, flutamide-treated males fed a phytoestrogen-rich diet outperformed flutamide-treated males switched to a phytoestrogen-free diet.
        
        
          Conclusions
          These results suggest that prenatal hormonal manipulations significantly sex-reverse the normal sexually dimorphic expression of VSM. Specifically, VSM was enhanced in females treated with testosterone and inhibited in males treated with flutamide. Finally, dietary soy phytoestrogens set a bias on learning and memory in these hormonally manipulated animals in a predictable manner and these data confirm and extend the findings in our companion paper (see Lund etal, BMC Neuroscience 2001 2:20).

Tags: nih, phytoestrogens, prenatal-hormones, sex-differences, spatial-memory
Organization: U.S. Department of Health & Human Services
Dynamic diversity of the tryptophan pathway in chlamydiae: reductive evolution and a novel operon for tryptophan recapture

The factors that accommodate the transition of different chlamydial species to the persistent state of pathogenesis include marked differences in the strategied deplyed to obtain tryptophan from host resources. Chlamydia psittaci appears to have a novel mechanism for intercepting an early intermediate of tryptophan catabolism and recycling it back to tryptophan.

Tags: chlamydia-psittaci, nih, reductive-evolution, tryptophan-pathway, tryptophan-recapture
Organization: U.S. Department of Health & Human Services
2021 Uniform Reporting System (URS) Table For Pennsylvania

This is the 2021 Uniform Reporting System (URS) Output Tables for Pennsylvania. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-program, community-mental-health, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Distribution of serotonergic and dopaminergic nerve fibers in the salivary gland complex of the cockroach

Background
          The cockroach salivary gland consists of secretory acini with peripheral ion-transporting cells and central protein-producing cells, an extensive duct system, and a pair of reservoirs. Salivation is controled by serotonergic and dopaminergic innervation. Serotonin stimulates the secretion of a protein-rich saliva, dopamine causes the production of a saliva without proteins. These findings suggest a model in which serotonin acts on the central cells and possibly other cell types, and dopamine acts selectively on the ion-transporting cells. To examine this model, we have analyzed the spatial relationship of dopaminergic and serotonergic nerve fibers to the various cell types.
        
        
          Results
          The acinar tissue is entangled in a meshwork of serotonergic and dopaminergic varicose fibers. Dopaminergic fibers reside only at the surface of the acini next to the peripheral cells. Serotonergic fibers invade the acini and form a dense network between central cells. Salivary duct segments close to the acini are locally associated with dopaminergic and serotonergic fibers, whereas duct segments further downstream have only dopaminergic fibers on their surface and within the epithelium. In addition, the reservoirs have both a dopaminergic and a serotonergic innervation.
        
        
          Conclusion
          Our results suggest that dopamine is released on the acinar surface, close to peripheral cells, and along the entire duct system. Serotonin is probably released close to peripheral and central cells, and at initial segments of the duct system. Moreover, the presence of serotonergic and dopaminergic fiber terminals on the reservoir indicates that the functions of this structure are also regulated by dopamine and serotonin.

Tags: cockroach-salivary-gland, dopaminergic-fibers, insect-neurobiology, nih, serotonergic-fibers
Organization: U.S. Department of Health & Human Services
Research Article: BMC Medical Genetics

Background
          SFHR (small fragment homologous replacement)-mediated targeting is a process that has been used to correct specific mutations in mammalian cells. This process involves both chemical and cellular factors that are not yet defined. To evaluate potential of this technique for gene therapy it is necessary to characterize gene transfer efficacy in terms of the transfection vehicle, the genetic target, and the cellular processing of the DNA and DNA-vehicle complex.
        
        
          Methods
          In this study, small fragments of genomic cystic fibrosis (CF) transmembrane conductance regulator (CFTR) DNA, that comprise the wild-type and ΔF508 sequences, were transfected into immortalized CF and normal airway epithelial cells, respectively. Homologous replacement was evaluated using PCR and sequence-based analyses of cellular DNA and RNA. Individual stages of cationic lipid-facilitated SFHR in cultured cell lines were also examined using transmission electron microscopy (TEM).
        
        
          Results
          We demonstrated that the lipid/DNA (+/-) ratio influences the mode of entry into the cell and therefore affects the efficacy of SFHR-mediated gene targeting. Lipid/DNA complexes with more negative ratios entered the cell via a plasma membrane fusion pathway. Transfer of the DNA that relies on an endocytic pathway appeared more effective at mediating SFHR. In addition, it was also clear that there is a correlation between the specific cell line transfected and the optimal lipid/DNA ratio.
        
        
          Conclusions
          These studies provide new insights into factors that underlie SFHR-mediated gene targeting efficacy and into the parameters that can be modulated for its optimization.

Tags: cftr-gene, cystic-fibrosis, gene-therapy, medical-genetics, nih
Organization: U.S. Department of Health & Human Services
The NSDUH Report: Need for and Receipt of Substance Use Treatment among American Indians or Alaska Natives

This report uses 2003 to 2011 National Survey on Drug Use and Health (NSDUH) to assess past year need for and receipt of alcohol use treatment and illicit drug use treatment among American Indian or Alaska Natives aged 12 or older in comparison to persons of other racial and ethnic groups. Results are shown by age group, gender, federal poverty level and rural/urban status.

Tags: alcohol-drug-abuse, american-indian-alaska-native, samhsa, substance-use-treatment, treatment-access
Organization: U.S. Department of Health & Human Services
Wyoming (WY)

This report uses 2008 to 2010 National Survey on Drug Use and Health (NSDUH) to assess past year alcohol use disorder and illicit drug use disorder among persons aged 12 or older for Wyoming overall and for substate regions within Wyoming. Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE).

Tags: mental-health-indicators, nsduh-data, samhsa, substance-use-disorder, wyoming-health
Organization: U.S. Department of Health & Human Services
FY 2013 Children's Bureau Discretionary Grant Awards

This document provides a list of Children's Bureau discretionary grants awarded in fiscal year 2013:

Tribal Title IV-E Plan Development Grants HHS-2013-ACF-ACYF-CS-0579

Up to $300,000 for one 24 month project/budget period

Building Child Welfare Capacity for Continuous Improvement Project HHS-2013-ACF-ACYF-CO-0580

Up to $2,000,000 for one 17 month project/budget period

Adoption Recruitment Campaign and Response Initiative HHS-2013-ACF-ACYF-CO-0586

Up to $1,500,000 per budget period with up to one 6-month and four 12-month budget periods

Comprehensive Support Services for Families Affected by Substance Abuse and HIV/AIDS HHS-2013-ACF-ACYF-CB-0592

Up to $475,000 per year for up to three years

Diligent Recruitment of Families for Children in the Foster Care System HHS-2013-ACF-ACYF-CO-0593

Up to $400,000 per year for up to five years

Child Welfare Training: The National Center for Child Welfare Curriculum Development on Evidence-Based Treatment Services HHS-2013-ACF-ACYF-CT-0595

Up to $1,000,000 per year for up to five years

Child Welfare Training: The National Child Welfare Workforce Institute HHS-2013-ACF-ACYF-CT-0596

Up to $4,100,000 per year for up to five years

Planning Grants to Develop a Model Intervention for Youth/Young Adults with Child Welfare Involvement At-Risk of Homelessness HHS-2013-ACF-ACYF-CA-0636

Up to $360,000 per year for up to two years

Promoting Well-Being and Adoption after Trauma HHS-2013-ACF-ACYF-CO-0637

Up to $500,000 per year for up to five years

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: adoption, child, fiscal, grant, policy
Organization: U.S. Department of Health & Human Services
Compound 525148: 1-Propanol, 2-(2-(acetyloxy)propoxy)-, 1-acetate

Chemical compound data from PubChem database. IUPAC Name: 2-(2-acetyloxypropoxy)propyl acetate. Molecular Formula: C10H18O5. Molecular Weight: 218.25. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2021 Uniform Reporting System (URS) Table For South Dakota

This is the 2021 Uniform Reporting System (URS) Output Tables for South Dakota. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant, mental-health-services, outcome-measures, samhsa, south-dakota
Organization: U.S. Department of Health & Human Services
Results from the 2012 National Survey on Drug Use and Health: Mental Health Findings

This report present results from the 2012 National Survey on Drug Use and Health (NSDUH) Mental Health Findings, including national estimates of the prevalence of past year mental disorders and past year mental health service utilization for youths aged 12 to 17 and adults aged 18 or older. Among adults, estimates presented include rates and numbers of persons with any mental illness (AMI), serious mental illness (SMI), suicidal thoughts and behavior, major depressive episode (MDE), treatment for depression (among adults with MDE), and mental health service utilization. Estimates for youths include MDE, treatment for depression (among youths with MDE), and mental health service utilization. Measures related to the co-occurrence of mental disorders with substance use or with substance use disorders also are presented for both adults and youths. The report focuses mainly on trends between 2011 and 2012.  Results are also provided by age group, gender, race/ethnicity, education level, employment status, county type, poverty level, insurance status, overal health, and geographic area.

Tags: mental-health, mental-illness, national-survey, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Microarray profile of differentially expressed genes in a monkey model of allergic asthma

Background
          Inhalation of Ascaris suum antigen by allergic monkeys causes an immediate bronchoconstriction and delayed allergic reaction, including a pulmonary inflammatory infiltrate. To identify genes involved in this process, the gene-expression pattern of allergic monkey lungs was profiled by microarrays. Monkeys were challenged by inhalation of A. suum antigen or given interleukin-4 (IL-4) treatment; lung tissue was collected at 4, 18 or 24 h after antigen challenge or 24 h after IL-4. Each challenged monkey lung was compared to a pool of normal, unchallenged monkey lungs.
        
        
          Results
          Of the approximately 40,000 cDNAs represented on the microarray, expression levels of 169 changed by more than 2.5-fold in at least one of the pairwise probe comparisons; these cDNAs encoded 149 genes, of which two thirds are known genes. The largest number of regulated genes was observed 4 h after challenge. Confirmation of differential expression in the original tissue was obtained for 95% of a set of these genes using real-time PCR. Cluster analysis revealed at least five groups of genes with unique expression patterns. One cluster contained genes for several chemokine mediators including eotaxin, PARC, MCP-1 and MCP-3. Genes involved in tissue remodeling and antioxidant responses were also identified as regulated by antigen and IL-4 or by antigen only.
        
        
          Conclusion
          This study provides a large-scale profile of gene expression in the primate lung following allergen or IL-4 challenge. It shows that microarrays, with real-time PCR, are a powerful tool for identifying and validating differentially expressed genes in a disease model.

Tags: airway-inflammation, allergic-asthma, gene-expression, monkey-model, nih
Organization: U.S. Department of Health & Human Services
California (CA)

This report presents California\'s estimates for 25 measures of substance use and mental health based on the combined 2009 and 2010 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for California for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: california-survey, mental-health, nsduh-data, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
NCCAN 16 Plenary Session IV

This resource provides a transcript of Plenary Session IV of the 16th National Conference on Child Abuse and Neglect.

The Honorable Stephen M. Rubin describes how one community used collaboration over a ten-year period to reform its child welfare system totally. He explores the annual goals of the collaboration, as well as the process implemented to realize these goals across multiple systems. Judge Rubin, a practicing lawyer for 12 years prior to his appointment to the Pima County Bench in 1987, has served as an Adjunct Professor of Law at the University of Arizona College of Law; as co-creator of the Child Abuse and Neglect Institute offered annually at the National College of Juvenile Law in Reno, Nevada; and as President of the National Council of Juvenile and Family Court Judges and, currently, as Immediate Past President.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: abuse, neglect, policy, real, time
Organization: U.S. Department of Health & Human Services
Mutational analysis of Peroxiredoxin IV: exclusion of a positional candidate for multinodular goitre

Background
          Multinodular goitre (MNG) is a common disorder characterised by an enlargement of the thyroid, occurring as a compensatory response to hormonogenesis impairment. The incidence of MNG is dependent on sex (female:male ratio 5:1) and several reports have documented a genetic basis for the disease. Last year we mapped a MNG locus to chromosome Xp22 in a region containing the peroxiredoxin IV (Prx-IV) gene. Since Prx-IV is involved in the removal of H2O2 in thyroid cells, we hypothesize that mutations in Prx-IV gene are involved in pathogenesis of MNG.
        
        
          Methods
          Four individuals (2 affected, 2 unrelated unaffected) were sequenced using automated methods. All individuals were originated from the original three-generation Italian family described in previous studies. A Southern blot analysis using a Prx-IV full-length cDNA as a probe was performed in order to exclude genomic rearrangements and/or intronic mutations. In addition a RT-PCR of PRX-IV was performed in order to investigate expression alterations.
        
        
          Results
          No causative mutations were found. Two adjacent nucleotide substitutions were detected within introns 1 and 4. These changes were also detected in unaffected individuals, suggesting that they were innocuous polymorphisms. No gross genomic rearrangements and/or restriction fragment alterations were observed on Southern analysis. Finally, using RT-PCR from tissue-specific RNA, no differences of PRX-IV expression-levels were detected between affected and unaffected samples.
        
        
          Conclusions
          Based on sequence and genomic analysis, Prx-IV is very unlikely to be the MNG2 gene.

Tags: genetic-mutation, multinodular-goitre, nih, peroxiredoxin-iv, thyroid-disease
Organization: U.S. Department of Health & Human Services
2020 Uniform Reporting System (URS) Table For Alaska

This is the 2020 Uniform Reporting System (URS) Output Tables for Alaska. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: alaska-mental-health, mental-health-services, national-outcome-measures, samhsa, substance-abuse-treatment
Organization: U.S. Department of Health & Human Services
2010 CMHS Uniform Reporting System (URS) Output Tables for Tennessee

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2010. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, national-outcome-measures, samhsa, urs-data
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Arizona, 2013

This is a behavioral health report for the state of Arizona.  It uses the  National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment Services (NSSATS) to address the topics of youth substance use , youth mental health and treatment, adult mental health and treatment, substance use,  and substance use treatment,  for the years 2008 to 2012.

Tags: arizona-behavioral-health, mental-health-arizona, samhsa, substance-use-arizona, youth-behavioral-health
Organization: U.S. Department of Health & Human Services
2021 Uniform Reporting System (URS) Table For Wisconsin

This is the 2021 Uniform Reporting System (URS) Output Tables for Wisconsin. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant, evidence-based-practices, mental-health-services, outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services