AndreaBozzo/ceres-open-data-index huggingface dataset:
The emerging periplasm-localized subclass of AroQ chorismate mutases, exemplified by those from

Background
          Chorismate mutases of the AroQ homology class are widespread in the Bacteria and the Archaea. Many of these exist as domains that are fused with other aromatic-pathway catalytic domains. Among the monofunctional AroQ proteins, that from Erwinia herbicola was previously shown to have a cleavable signal peptide and located in the periplasmic compartment. Whether or not this might be unique to E. herbicola was unknown.
        
        
          Results
          The gene coding for the AroQ protein was cloned from Salmonella typhimurium, and the AroQ protein purified from both S. typhimurium and Pseudomonas aeruginosa was shown to have a periplasmic location. The periplasmic chorismate mutases (denoted *AroQ) are shown to be a distinct subclass of AroQ, being about twice the size of cytoplasmic AroQ proteins. The increased size is due to a carboxy-terminal extension of unknown function. In addition, a so-far novel aromatic aminotransferase was shown to be present in the periplasm of P. aeruginosa.
        
        
          Conclusions
          Our analysis has detected a number of additional *aroQ genes. The joint presence of *AroQ, cyclohexadienyl dehydratase and aromatic aminotransferase in the periplasmic compartment of P. aeruginosa comprises a complete chorismate-to-phenylalanine pathway and accounts for the "hidden overflow pathway" to phenylalanine described previously.

Tags: aroq-protein, chorismate-mutases, nih, periplasmic-localization, salmonella-typhimurium
Organization: U.S. Department of Health & Human Services
Compound 530585: Hexadecyl p-toluate

Chemical compound data from PubChem database. IUPAC Name: hexadecyl 4-methylbenzoate. Molecular Formula: C24H40O2. Molecular Weight: 360.6. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Patent AT-E401212-T1: [Translated] INSTRUMENT PANEL AND METHOD FOR PRODUCING THE SAME

The dashboard, in particular, for motor vehicles comprises a frame structure of linear elements (2), with at least some of the adjacent regions (4) closed by plastic plates attached to the linear elements by material bonds. Independent claims are also included for (a) a method for producing the proposed dashboard (b) a motor vehicle incorporating such a dashboard.

Tags: chemistry, innovation, patent, pubchem, research
Organization: U.S. Department of Health & Human Services
Compound 526396: 2,6-Dibromo,1,9-dichloro-dibenzo-dioxin

Chemical compound data from PubChem database. IUPAC Name: 2,6-dibromo-1,9-dichlorodibenzo-p-dioxin. Molecular Formula: C12H4Br2Cl2O2. Molecular Weight: 410.9. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 525100: 1,3-Dichloroisopropyl nonanoate

Chemical compound data from PubChem database. IUPAC Name: 1,2-dichloropropan-2-yl nonanoate. Molecular Formula: C12H22Cl2O2. Molecular Weight: 269.2. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 527523: Tetradecyl 2-bromobutanoate

Chemical compound data from PubChem database. IUPAC Name: tetradecyl 2-bromobutanoate. Molecular Formula: C18H35BrO2. Molecular Weight: 363.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 528555: Octadecane, 4-ethyl

Chemical compound data from PubChem database. IUPAC Name: 4-ethyloctadecane. Molecular Formula: C20H42. Molecular Weight: 282.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 528643: Trimethylsilyl 2-methyl-3-[(trimethylsilyl)oxy]pentanoate

Chemical compound data from PubChem database. IUPAC Name: trimethylsilyl 2-methyl-3-trimethylsilyloxypentanoate. Molecular Formula: C12H28O3Si2. Molecular Weight: 276.52. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 530539: 4-Butylbenzoic acid, hexadecyl ester

Chemical compound data from PubChem database. IUPAC Name: hexadecyl 4-butylbenzoate. Molecular Formula: C27H46O2. Molecular Weight: 402.7. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 528663: Creatinine, TMS

Chemical compound data from PubChem database. IUPAC Name: 3-methyl-N-trimethylsilyl-5-trimethylsilyloxy-4H-imidazol-2-imine. Molecular Formula: C10H23N3OSi2. Molecular Weight: 257.48. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 530077: 1,4-Dimethylhistidine, TMS

Chemical compound data from PubChem database. IUPAC Name: trimethylsilyl 3-(3,5-dimethylimidazol-4-yl)-2-(trimethylsilylamino)propanoate. Molecular Formula: C14H29N3O2Si2. Molecular Weight: 327.57. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2013 CMHS Uniform Reporting System (URS) Tables for Arizona

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Tables for Arizona for 2013. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program.  State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: arizona-mental-health, mental-health-services, noms-measures, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
Compound 526514: Ethyl 3-isothiocyanatopropionate

Chemical compound data from PubChem database. IUPAC Name: ethyl 3-isothiocyanatopropanoate. Molecular Formula: C6H9NO2S. Molecular Weight: 159.21. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
A Problem with the Individual Approach in the WHO Health Inequality Measurement

Background
          In the World Health Report 2000, the World Health Organization made the controversial choice to measure inequality across individuals rather than across groups, the standard in the field. This choice has been widely discussed and criticized.
        
        
          Discussion
          We look at the three questions: (1) is the World Health Organization's health inequality measure value-free as it claims? (2) if it is not, what is the normative position implied by its approach when measuring health inequality? and (3) is the individual approach a logically consistent methodological choice for that normative position?
        
        
          Summary
          We argue that the World Health Organization's health inequality measure is not value-free. If it was, the health inequality information that the measurement collected could not reasonably be included in its ranking of how well national health systems performed. The World Health Organization's normative position can be interpreted as a quite expansive view of justice, in which health distributions that have causes amenable to human intervention are considered to be matters of justice. Our conclusion is that if the World Health Organization's health inequality measure is to be interpreted meaningfully in a policy context, its conceptual underpinning must be re-evaluated.

Tags: health-inequality, health-measurement, health-systems, nih, world-health-organization
Organization: U.S. Department of Health & Human Services
2022 Uniform Reporting System (URS) Table For Rhode Island

This is the 2022 Uniform Reporting System (URS) Output Tables for Rhode Island. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-program, mental-health-services, national-outcome-measures, rhode-island, samhsa
Organization: U.S. Department of Health & Human Services
Compound 525680: N-(4-Chlorobenzylidene)-M-toluidine

Chemical compound data from PubChem database. IUPAC Name: 1-(4-chlorophenyl)-N-(3-methylphenyl)methanimine. Molecular Formula: C14H12ClN. Molecular Weight: 229.7. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Patent AT-E399583-T1: [Translated] ADJUSTABLE DUMBBELL WITH COMMERCIAL WEIGHTS

This invention relates to a selectorized dumbbell having a handle (4) that can be dropped down between nested left and right stacks of weight plates (32). The weight plates can comprise individual weights or a pair of weight plates, one from each stack, can be connected together to form a single weight (6). A selector (8) is provided to allow the user to select a desired number of weight plates from each stack and couple such weight plates to the handle to provide an adjustable weight dumbbell. Each weight includes a weight frame (20) having at least one carrier (30) to which a commodity weight can be fastened. The dumbbell can be shipped by the manufacturer with empty weight frames to reduce shipping costs. When the dumbbell with empty weight frames reaches a destination, the dumbbell can be completed by securing commodity weights to the carriers on the respective weight frames. <IMAGE> <IMAGE>

Tags: chemistry, innovation, patent, pubchem, research
Organization: U.S. Department of Health & Human Services
Compound 529463: N-(Octan-2-yl)acetamide

Chemical compound data from PubChem database. IUPAC Name: N-octan-2-ylacetamide. Molecular Formula: C10H21NO. Molecular Weight: 171.28. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Patent AT-E401752-T1: [Translated] METHOD AND ARRANGEMENT FOR PROVIDING A CONNECTION PATH TO A MOBILE RADIO NETWORK AND A SUITABLE TELECOMMUNICATIONS TERMINAL DEVICE FOR THIS

A method for setting up a connection path to a mobile RF network in which, as a connection path between a telecommunications terminal (1) and the access-and-switching units (9,10) of the mobile RF network a radio link (12), or a connection path (13) including the Internet (8) is automatically used, in which the Internet connection path (8,13) is handled as a further RF cell of the mobile RF network, by the access and switching-units (9,10,11), as well as the telecommunications terminal (1), with regard to the relationship with the switch-on of the telecommunications terminal (1) and its booking or log-on during sequences with the mobile RF network as well as a switch-over in the course of a changeover or hand-over of the connection path between the radio link (12) and Internet path (8,13) or vice versa.  Independent claims are included for (A) an arrangement for carrying out the method and (B) a telecommunications terminal for carrying out the method.

Tags: chemistry, innovation, patent, pubchem, research
Organization: U.S. Department of Health & Human Services
2010 CMHS Uniform Reporting System (URS) Output Tables for Louisiana

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2010. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, noms-measures, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
Compound 527457: 2-Methyl-1-heptadecene

Chemical compound data from PubChem database. IUPAC Name: 2-methylheptadec-1-ene. Molecular Formula: C18H36. Molecular Weight: 252.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 528697: Trimethylsilyl 4,8-bis[(trimethylsilyl)oxy]-2-quinolinecarboxylate

Chemical compound data from PubChem database. IUPAC Name: trimethylsilyl 4,8-bis(trimethylsilyloxy)quinoline-2-carboxylate. Molecular Formula: C19H31NO4Si3. Molecular Weight: 421.7. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 529775: 2,4-Pentadecadione

Chemical compound data from PubChem database. IUPAC Name: pentadecane-2,4-dione. Molecular Formula: C15H28O2. Molecular Weight: 240.38. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 525421: Sulfide, isopentyl pentyl

Chemical compound data from PubChem database. IUPAC Name: 1-(3-methylbutylsulfanyl)pentane. Molecular Formula: C10H22S. Molecular Weight: 174.35. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Patent AT-E399682-T1: [Translated] REAR EXTENSION FOR A MOTOR VEHICLE

A rear-end extension for a motor vehicle, which can be fixed to a rear end cutout on the body of a vehicle with the aid of detachable fixing means is known per se. According to the invention, a dimensionally stable rear-end module is provided, the end contour thereof being adapted to a peripheral edge of the cut out of the body of the vehicle in such a way that the rear-end module can be joined to the rear-end cutout of the body of the vehicle in a peripherally flush manner. The fixing means are adapted to the fixing points, on the vehicle body, of at least one vehicle-body rear-end part provided for closing the cutout of the vehicle body such that the rear-end module can be detachably fixed to the rear-end cutout on the body of the vehicle using fixing points for the vehicle-body rear-end part when the vehicle-body rear-end part is in a remote position. The invention can be used for passenger cars having a steeply inclined rear end.

Tags: chemistry, innovation, patent, pubchem, research
Organization: U.S. Department of Health & Human Services
Compound 528300: Pyrazine, 2-decyl-3-ethylthio

Chemical compound data from PubChem database. IUPAC Name: 2-decyl-3-ethylsulfanylpyrazine. Molecular Formula: C16H28N2S. Molecular Weight: 280.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Treatment of achalasia: the short-term response to botulinum toxin injection seems to be independent of any kind of pretreatment

Background
          It has been suggested that intrasphincteric injection of botulinum toxin (BTX) may represent an alternative therapy to balloon dilatation in achalasia. The aim of the present study was to test the effectiveness of botulinum toxin injections in achalasia patients, as assessed using lower oesophageal sphincter pressure (LOSP) and symptom scores, and to compare the response in patients with different types of pretreatment (no previous treatment, balloon dilatation, myotomy, BTX injection).
        
        
          Methods
          Forty patients who presented with symptomatic achalasia were treated with BTX injection (48 injections in 40 patients). Some of the patients had received prior treatment (seven with myotomy, seven with dilatation and eight with BTX). The symptoms were assessed using a global symptom score (0–10), which was evaluated before treatment, 1 week afterwards, and 1 month afterwards. Manometry was also carried out before and after treatment. Three different selections of patients were studied: all patients; untreated patients; and patients with prior BTX, dilatation, or myotomy.
        
        
          Results
          After BTX injection, there was a significant reduction in LOSP (before, 38.2 ± 11.3 mmHg; 1 week after, 20.5 ± 6.9 mmHg; 1 month after, 17.8 ± 6.8 mmHg; P < 0.001). The global symptom score and symptom subscores (dysphagia, regurgitation, chest pain) were significantly decreased after 1 week and 1 month. When the beneficial effects following BTX injection were compared (untreated vs. pretreated), neither changes in LOSP nor beneficial effects on the symptom scores significantly differed. After 6 months, 67.7% of all treated patients were still in symptomatic remission (subgroups: previously untreated patients, 61.5%, n = 26; prior dilatation, 71.4%, n = 7; prior myotomy, 71.4%, n = 7; prior BTX, 73.9%, n = 8).
        
        
          Conclusions
          BTX injection offers an alternative treatment for achalasia which is safe and can be performed in an outpatient setting. The initial response to BTX, in terms of symptom scores and LOSP, appears to be independent of any prior treatment. A number of patients do not adequately respond to balloon dilatation or myotomy, which are the first-line treatment modalities in achalasia patients. BTX injection can be performed in these patients, and symptomatic benefit can be expected in the same percentages as with BTX injection in untreated patients.

Tags: achalasia-treatment, botulinum-toxin, esophageal-motility, manometry-data, nih
Organization: U.S. Department of Health & Human Services
Antibiotics for coughing in general practice: a questionnaire study to quantify and condense the reasons for prescribing

Background
          Antibiotics are being overprescribed in ambulant care, especially for respiratory tract infections (RTIs). Gaining insight into the actual reasons for prescribing remains important for the design of effective strategies to optimise antibiotic prescribing. We aimed to determine items of importance for the antibiotic prescribing decision and to make them operational for an intervention trial.
        
        
          Methods
          A postal questionnaire based upon focus group findings was sent to 316 Flemish general practitioners (GPs). On a verbal rating scale the GPs scored to what extent they consider the questionnaire items in decision making in case of suspected RTI in a coughing patient and how strongly the items support or counter antibiotic treatment. Factor analysis was used to condense the data. The relative importance of the yielded operational factors was assessed using Wilcoxon Matched Pairs test.
        
        
          Results
          59.5% completed the study. Response group characteristics (mean age: 42.8 years; 65.9% men) approximated that of all Flemish GPs. Participants considered all the items included in the questionnaire: always the operational factor 'lung auscultation', often 'whether or not there is something unusual happening' – both medical reasons – and to a lesser extent 'non-medical reasons' (P < 0.001). Non-medical as well as medical reasons support antibiotic treatment, but non-medical reasons to a lesser extent (P < 0.001).
        
        
          Conclusion
          This study quantified, condensed and confirmed the findings of previous focus group research. Practice guidelines and interventions to optimise antibiotic prescribing have to take non-medical reasons into account.

Tags: antibiotic-prescribing, cough-treatment, general-practice, nih, respiratory-tract-infections
Organization: U.S. Department of Health & Human Services
Patent AT-E401330-T1: [Translated] 2,3-OLEFINIC EPOTHILONE DERIVATIVES

The present invention relates to 2,3-position modified epothilone derivatives, methods of preparation of the derivatives, and intermediates therefor. The compounds of the invention as 16-membered macrolides having the general structure,which have microtubule-stabilizing effects and cytotoxic activity against rapidly proliferating cells, such as, tumor cells or other hyperproliferative cellular disease.

Tags: chemistry, innovation, patent, pubchem, research
Organization: U.S. Department of Health & Human Services
Nonresponse Bias in Demographic and Survey Estimates from the Mental Health Surveillance Study of the National Survey on Drug Use and Health

This report summarizes the differences between respondents and nonrespondents at the two stages of nonresponse in the clinical follow-up component of NSDUH. Differences between respondents and nonrespondents were examined in addition to nonresponse biases in a variety of demographic and substantive measures related to the key outcome measures at the two stages.

Tags: mental-health-surveillance, nonresponse-bias, nsduh, samhsa, survey-estimates
Organization: U.S. Department of Health & Human Services