AndreaBozzo/ceres-open-data-index huggingface dataset:
Using single nucleotide polymorphisms as a means to understanding the pathophysiology of asthma

Asthma is the most common chronic childhood disease in the developed nations, and is a complex disease that has high social and economic costs. Studies of the genetic etiology of asthma offer a way of improving our understanding of its pathogenesis, with the goal of improving preventive strategies, diagnostic tools, and therapies. Considerable effort and expense have been expended in attempts to detect specific polymorphisms in genetic loci contributing to asthma susceptibility. Concomitantly, the technology for detecting single nucleotide polymorphisms (SNPs) has undergone rapid development, extensive catalogues of SNPs across the genome have been constructed, and SNPs have been increasingly used as a method of investigating the genetic etiology of complex human diseases. This paper reviews both current and potential future contributions of SNPs to our understanding of asthma pathophysiology.

Tags: asthma-pathophysiology, asthma-susceptibility, genetic-etiology, nih, snp-analysis
Organization: U.S. Department of Health & Human Services
Benefits and side effects of blood pressure lowering treatment: what was wrong with doxazosin in the ALLHAT?

The lowering of high blood pressure is supposed to protect target organs from hypertensive damage. The Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial was designed to compare the cardioprotective properties of three antihypertensives from different classes (lisinopril, amlodipine and doxazosin) with chlorthalidone. Despite effective blood pressure lowering and a favorable metabolic profile, the doxazosin arm of the trial had a significantly higher relative risk of cardiovascular disease and heart failure compared with the chlorthalidone arm. This article speculates on possible causes for this unexpected result and suggests that the culprit may be accentuation of the vascular effects of vasopressin, which are maximized under α-adrenergic blockade. These findings may have implications for the large number of older men who receive monotherapy with α-blockers for treatment of prostatic symptoms.

Tags: allhat-trial, antihypertensive-treatment, blood-pressure, doxazosin-side-effects, nih
Organization: U.S. Department of Health & Human Services
2018 Uniform Reporting System (URS) Table for West Virginia

This is the 2018 Uniform Reporting System (URS) Output Tables for West Virginia. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: mental-health-services, national-outcome-measures, samhsa, substance-abuse-treatment, west-virginia
Organization: U.S. Department of Health & Human Services
Psychological Distress and Mortality among Adults in the U.S. Household Population

This study used data from the public use files of the 1997 to 2004 National Health Interview Survey (NHIS), which were linked to death certificate data from the 1997 to 2006 National Death Index (NDI), to assess the association between psychological distress and mortality.

Tags: all-cause-mortality, national-death-index, national-health-interview-survey, psychological-distress, samhsa
Organization: U.S. Department of Health & Human Services
2022 Uniform Reporting System (URS) Table For New Jersey

This is the 2022 Uniform Reporting System (URS) Output Tables for New Jersey. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-data, evidence-based-practices, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Availability of Fiscal Year (FY) 2024 Children's Justice Act Grants to States Under the Child Abuse Prevention and Treatment Act (CAPTA) as Amended by Public Law (P.L.) 115-271

This Program Instruction (PI) sets forth the eligibility requirements and the grant application procedures for FY 2024 Children's Justice Act (CJA) grants and provides the tentative State allocation table.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: abuse, fiscal, grant, instruction, prevention
Organization: U.S. Department of Health & Human Services
Apoptosis and p53 expression in rat adjuvant arthritis

The kinetics of apoptosis and the apoptosis-regulating gene
			 p53 in adjuvant arthritis (AA) were investigated to assess the value
			 of the AA rat model for testing apoptosis-inducing therapies. Very few terminal
			 deoxynucleotidyl transferase-mediated deoxyuridine triphosphate (dUTP) nick
			 end-labeling (TUNEL)-positive cells were detected during the early phases of
			 AA, but on day 23 (chronic arthritis) the percentage of TUNEL-positive cells
			 was significantly increased. Expression of p53 in synovial tissue
			 gradually increased from days 5-23, which was markedly higher than p53
			 levels in rheumatoid arthritis (RA) synovium. Significant apoptosis only occurs
			 late in rat AA and is concordant with marked p53 overexpression,
			 making it useful model for testing proapoptotic therapies, but rat AA is not
			 the best model for p53 gene therapy because dramatic p53
			 overexpression occurs in the latter stages of the disease.

Tags: adjuvant-arthritis, apoptosis-kinetics, nih, p53-expression, rat-model
Organization: U.S. Department of Health & Human Services
Symptomatic hemorrhage after alteplase therapy not due to silent ischemia

Background
          Stroke thrombolysis-related intracerebral hemorrhage may occur remotely from the anatomical site of ischemia. One postulated mechanism for this is simultaneous multiple embolization with hemorrhage into a "silent" area of ischemia.
        
        
          Results
          A patient suffered a disabling stroke affecting the right cerebral hemisphere. He was treated with intravenous alteplase and underwent extensive early imaging with multimodal MRI. Several hours after treatment he developed a brainstem hemorrhage despite having no evidence of ischemia on DWI MRI in the brainstem.
        
        
          Conclusion
          Not all occurrences of remote ICH after stroke thrombolysis are secondary to multiple emboli with silent ischemia.

Tags: alteplase-therapy, brainstem-hemorrhage, intracerebral-hemorrhage, nih, stroke-thrombolysis
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Nevada, 2014

This is a behavioral health report for the state of Nevada. It uses the  National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment Services (NSSATS) to address the topics of youth substance use , youth mental health and treatment, adult mental health and treatment, substance use, substance use treatment, and medicare enrollees for the years 2009 to 2013.

Tags: adult-mental-health, nevada-behavioral-health, samhsa, substance-use-treatment, youth-substance-use
Organization: U.S. Department of Health & Human Services
Compound 528476: Decane, 4,5-dimethyl-

Chemical compound data from PubChem database. IUPAC Name: 4,5-dimethyldecane. Molecular Formula: C12H26. Molecular Weight: 170.33. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Tobacco Product and Alcohol Use Tables  (Prevalence Estimates) - 2.1 to 2.84

These detailed tables are population tobacco and alcohol use totals and prevalence estimates from the 2011 National Survey on Drug Use and Health (NSDUH). Tobacco products include cigarettes, smokeless tobacco, cigars, and pipe tobacco. Alcohol use includes binge and heavy alcohol use. Results are provided for lifetime, past year, and past month use by age group, gender, race/ethnicity, education level, employment status, and geographic area. Comparisons are made between 2011 and 2010.

Tags: alcohol-consumption, nsduh-survey, samhsa, substance-use, tobacco-use
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Michigan, 2013

This is a behavioral health report for the state of Michigan. It uses the  National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment Services (NSSATS) to address the topics of youth substance use , youth mental health and treatment, adult mental health and treatment, substance use, substance use treatment for the years 2008 to 2012.

Tags: adult-mental-health, michigan-behavioral-health, samhsa, substance-abuse-treatment, youth-substance-use
Organization: U.S. Department of Health & Human Services
Compound 528563: Lactic acid, diTBDMS

Chemical compound data from PubChem database. IUPAC Name: [tert-butyl(dimethyl)silyl] 2-[tert-butyl(dimethyl)silyl]oxypropanoate. Molecular Formula: C15H34O3Si2. Molecular Weight: 318.6. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Maine, 2013

This is a behavioral health report for the state of Maine. It uses the  National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment Services (NSSATS) to address the topics of youth substance use , youth mental health and treatment, adult mental health and treatment, substance use, substance use treatment for the years 2008 to 2012.

Tags: adult-mental-health, maine-behavioral-health, samhsa, substance-abuse-treatment, youth-substance-use
Organization: U.S. Department of Health & Human Services
Adverse effects of the antimalaria drug, mefloquine: due to primary liver damage with secondary thyroid involvement?

Background
          Mefloquine is a clinically important antimalaria drug, which is often not well tolerated. We critically reviewed 516 published case reports of mefloquine adverse effects, to clarify the phenomenology of the harms associated with mefloquine, and to make recommendations for safer prescribing.
        
        
          Presentation
          We postulate that many of the adverse effects of mefloquine are a post-hepatic syndrome caused by primary liver damage. In some users we believe that symptomatic thyroid disturbance occurs, either independently or as a secondary consequence of the hepatocellular injury. The mefloquine syndrome presents in a variety of ways including headache, gastrointestinal disturbances, nervousness, fatigue, disorders of sleep, mood, memory and concentration, and occasionally frank psychosis. Previous liver or thyroid disease, and concurrent insults to the liver (such as from alcohol, dehydration, an oral contraceptive pill, recreational drugs, and other liver-damaging drugs) may be related to the development of severe or prolonged adverse reactions to mefloquine.
        
        
          Implications
          We believe that people with active liver or thyroid disease should not take mefloquine, whereas those with fully resolved neuropsychiatric illness may do so safely. Mefloquine users should avoid alcohol, recreational drugs, hormonal contraception and co-medications known to cause liver damage or thyroid damage. With these caveats, we believe that mefloquine may be safely prescribed in pregnancy, and also to occupational groups who carry out safety-critical tasks.
        
        
          Testing
          Mefloquine's adverse effects need to be investigated through a multicentre cohort study, with small controlled studies testing specific elements of the hypothesis.

Tags: antimalarial-drugs, liver-damage, mefloquine-adverse-effects, nih, thyroid-dysfunction
Organization: U.S. Department of Health & Human Services
A comparison of efficacy and toxicity between electroporation and adenoviral gene transfer

Background
          Electroporation of skeletal muscle after injection of naked DNA was shown by others to increase transgene expression. Information regarding tissue damage caused by electroporation is conflicting. It is also not well known how plasmid electroporation compares with transfection by adenoviral vectors. To investigate these questions the most used protocol for muscle electroporation was used, i.e. 8 pulses of 200 V/cm and 20 ms at a frequency of 1 Hz.
        
        
          Results
          Intra-muscular DNA transfer of pLuciferase was increased by 2 logs after electroporation, confirming data described by others. However, the blood levels of the encoded protein were still lower than those obtained after injection of first generation adenoviral vectors. Also, the electroporation procedure, on its own, caused severe muscle damage consisting of rhabdomyolysis and infiltration, whereas the adenoviral vectors caused only a slight infiltration. As damage of targeted tissue may be an advantage in the case of tumour transfection, we also compared the two transfection methods in tumour tissue. In case of poorly permissive tumours, adenoviral vectors cannot transfect more than 2% of the tumour tissue without inducing significant liver damage. In contrast, the electroporation seems to offer a wider therapeutic window since it does not cause any systemic toxicity and still induce's significant transfection.
        
        
          Conclusions
          Plasmid electroporation of the muscle induce severe local damage and is of no advantage over adenoviral vectors for obtaining high blood levels of a vector encoded protein. In contrast, electroporation of tumours might be safer than adenoviral gene transfer.

Tags: adenoviral-vectors, electroporation-gene-transfer, muscle-damage, nih, transgene-expression
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Mississippi, 2015

This is a behavioral health report for the state of Mississippi. The report utilizes data from the National Survey on Drug Use and Health (NSDUH), and the Uniform Reporting System. The topics addressed in the report include youth substance use, youth mental health and treatment, mental health and treatment, substance use and substance use treatment.

Tags: mental-health-treatment, mississippi-behavioral-health, nsduh-data, samhsa, youth-substance-use
Organization: U.S. Department of Health & Human Services
National Survey of Substance Abuse Treatment Services: State Profiles 2017

The 2017 National Survey of Substance Abuse Treatment Services (N-SSATS) is an annual survey of facilities providing substance abuse treatment. The N-SSATS, conducted by the Substance Abuse and Mental Health Services Administration (SAMHSA), is designed to collect data on the location, characteristics, services offered, and number of clients in treatment at alcohol and drug abuse facilities (both public and private) throughout the 50 states, the District of Columbia, and other U.S. jurisdictions.

Tags: behavioral-health-services, n-ssats, samhsa, substance-abuse-treatment, treatment-facilities
Organization: U.S. Department of Health & Human Services
Differential modulation of cellular death and survival pathways by conjugated bile acids

Background
          The liver-derived McNtcp.24 cells transport bile acids and show distinctive responses to the two classes of conjugated bile acids. Whereas taurine-conjugated bile acids are non-toxic, glycine-conjugated bile acids efficiently induce apoptosis. The aim of this study was to determine if the differential sensitivity is limited to cells that normally transport bile acids and if bile acid binding proteins could reduce bile acid-mediated apoptosis. The apical sodium/bile acid co-transporter (asbt) was expressed in Chinese hamster ovary (CHO) cells to establish active bile acid transport in a non-liver-derived cell model (CHO.asbt). A high-affinity bile acid binder was expressed in McNtcp.24 cells.
        
        
          Results
          The tolerance of McNtcp.24 cells to taurine-conjugated bile acids was associated with the stimulation of phosphatidylinositol 3-kinase (PI3K) activity. Treatment of CHO.asbt cells with taurine- and glycine-conjugated bile acids resulted in apoptosis. Unlike in McNtcp.24 cells, PI3K activity was not increased in CHO.asbt cells treated with taurine-conjugated bile acids. High level expression of a bile acid binder did not attenuate bile acid-induced cytotoxicity in McNtcp.24 cells.
        
        
          Conclusion
          The data suggest that McNtcp.24 cells possess a mechanism that can elaborate distinctive responses to the different classes of bile acids. Additionally, activation of a signaling pathway involving PI3K appears to be the dominant mechanism responsible for the tolerance of McNtcp.24 cells to taurine-conjugated bile acids.

Tags: apoptosis, bile-acids, cell-death, nih, phosphatidylinositol-3-kinase
Organization: U.S. Department of Health & Human Services
The Use of Web Services in Data Exchanges

This presentation provides an overview of web services, how they use different types of patterns, and their purpose in effectively exchanging data in real time between heterogeneous systems. The presentation introduces the concept of service-oriented architecture using web services and how these web services can be used to integrate diverse repositories of data as well as to create efficient solutions for sharing and accessing data across the enterprise.

The speaker for this presentation is Valter Borges, director, Information Systems, State of Connecticut Department of Children and Families.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: data, policy, reporting, scope, web
Organization: U.S. Department of Health & Human Services
Louisiana (LA)

This report presents estimates for measures of substance use and mental health based on the combined 2010 and 2011 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for Louisiana for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: louisiana-health, mental-health, nsduh-data, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Texas (TX)

This report presents estimates for measures of substance use and mental health based on the combined 2010 and 2011 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for Texas for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: mental-health, nsduh, samhsa, substance-use, texas
Organization: U.S. Department of Health & Human Services
Maryland: 2011-2012 NSDUH

This report presents Maryland\'s estimates for 25 measures of substance use and mental health based on the combined 2011 and 2012 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided by State and for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: major-depression, mental-health, samhsa, substance-use, suicidal-ideation
Organization: U.S. Department of Health & Human Services
Compound 528409: Oxazole, 4-methyl-2-propyl

Chemical compound data from PubChem database. IUPAC Name: 4-methyl-2-propyl-1,3-oxazole. Molecular Formula: C7H11NO. Molecular Weight: 125.17. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Publications Using SAMHSA DataMajor Depressive Episode among Adolescents Living in Poverty (2005 to 2010 NSDUH)

This report uses 2005 to 2010 National Survey on Drug Use and Health (NSDUH) to assess past year major depressive episode (MDE) with and without treatment among youth aged 12 to 17 living in poverty and youth not living in poverty.

Tags: adolescent-depression, mde-treatment, nsduh-data, poverty-mental-health, samhsa
Organization: U.S. Department of Health & Human Services
Effects of the 2013 Psychiatric Current Procedural Terminology Codes Revision on Psychotherapy

To determine whether the changes to the psychiatric Current Procedural Terminology (CPT) codes implemented in 2013 were associated with changes in types of services for which psychiatrists billed.Effects of the 2013 Psychiatric Current Procedural Terminology Codes Revision on Psychotherapy(link is external)

Tags: cpt-codes, mental-health, psychiatric-services, psychotherapy-billing, samhsa
Organization: U.S. Department of Health & Human Services
2012 State Profile - North Dakota

This is a National Survey of Substance Abuse Treatment Services (N-SSATS) annual report showing the state profile for North Dakota in 2012. N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 States, the District of Columbia, and other U.S. jurisdictions.

Tags: alcohol-drug-abuse, north-dakota, samhsa, substance-abuse-treatment, treatment-facilities
Organization: U.S. Department of Health & Human Services