AndreaBozzo/ceres-open-data-index huggingface dataset:
Effect of Interlukin-1β on proliferation of gastric epithelial cells in culture

Background
          Helicobacter pylori is the main risk factor for the development of non-cardia gastric cancer. Increased proliferation of the gastric mucosa is a feature of H. pylori infection. Mucosal interkeukin-1β production is increased in H. pylori infection and IL-1β genotypes associated with increased pro-inflammatory activity are risk factors for the development of gastric cancer. The effect of IL-1β on gastric epithelial cell proliferation has been examined in this study.
        
        
          Methods
          AGS cells were cultured with IL-1β. DNA synthesis was assed by [3H]thymidine incorporation and total viable cell numbers by MTT assay.
        
        
          Results
          IL-1β dose dependently increased DNA synthesis and cell numbers. The enhanced proliferation was blocked by interleukin-1 receptor antagonist. Addition of neutralising antibody to GM-CSF reduced IL-1β-stimulated proliferation by 31 ± 4 %. GM-CSF alone significantly stimulated proliferation. Addition or neutralisation of IL-8 had no effect on basal or IL-1β-stimulated proliferation. The tyrosine kinase inhibitor genistein completely blocked IL-1β-stimulated proliferation and inhibition of the extracellular signal related kinase pathway with PD 98059 inhibited IL-1β stimulated proliferation by 58 ± 5 %.
        
        
          Conclusions
          IL-1β stimulates proliferation in gastric epithelial cells. Autocrine stimulation by GM-CSF contributes to this proliferative response. Signalling via tyrosine kinase activity is essential to the mitogenic response to IL-1β. The extracellular signal related kinase pathway is involved in, but not essential to downstream signalling. IL-1β may contribute to the hyperproliferation seen in H. pylori- infected gastric mucosa, and be involved in the carcinogenic process.

Tags: cell-proliferation, gastric-cancer, interleukin-1, nih
Organization: U.S. Department of Health & Human Services
Tumor necrosis factor-α and muscle wasting: a cellular perspective

Tumor necrosis factor-α (TNF-α) is a polypeptide cytokine that has been associated with muscle wasting and weakness in inflammatory disease. Despite its potential importance in muscle pathology, the direct effects of TNF-α on skeletal muscle have remained undefined until recently. Studies of cultured muscle cells indicate that TNF-α disrupts the differentiation process and can promote catabolism in mature cells. The latter response appears to be mediated by reactive oxygen species and nuclear factor-κB which upregulate ubiquitin/proteasome activity. This commentary outlines our current understanding of TNF-α effects on skeletal muscle and the mechanism of TNF-α action.

Tags: muscle-wasting, nih, skeletal-muscle, tnf-alpha
Organization: U.S. Department of Health & Human Services
Cross-sectional study of morbidity, morbidity-associated factors and cost of treatment in Ngaoundere, Cameroon, with implications for health policy in developing countries and development assistance policy

Background
          In a population-based epidemiological study in Ngaoundere, Cameroon, we studied cross-sectional child morbidity and the cost of necessary investigation and treatment.
        
        
          Methods
          Three teams of two to three health workers visited haphazardly selected households in all major housing quarters. We asked permission to enter for a health survey. Children with cough, fever or weight loss as well as sick adults were offered free-of-charge local hospital examination and treatment.
        
        
          Results
          From 177 households with 1777 persons, 51 (2.9%) persons were referred. Thirty-five of them had an undiagnosed disease threatening individual health and in many cases also public health. Seven were hospitalised, including three adults with tuberculosis. Malnutrition was diagnosed in nine small children. Four patients had AIDS, seven had malaria. Average total cost for ambulant patients was 15 USD, for hospitalised patients 110 USD.
          In the households, almost half of the women 16–50 years of age had no schooling. Two per cent of women and nine per cent of men were daily smokers. Coughing children were more likely than non-coughing children to live in a household with at least one smoker (OR = 3.58, 95% CI 1.72 to 7.46), and they generally lived in more poor households (P = 0.018). Twelve of 16 children with weight loss were referred from households with a high poverty score.
        
        
          Conclusions
          Adult smoking and poverty affect children's health. The cost of hospitalisation or long-lasting therapy is beyond the means of most ordinary families. Diseases with severe consequences for public health, like tuberculosis, AIDS and malaria should have national programs with free, decentralised examination and treatment. Access to generic drugs is important. A major educational effort is needed to improve public health.

Tags: child-morbidity, healthcare-costs, malaria-incidence, nih, tuberculosis-prevalence
Organization: U.S. Department of Health & Human Services
Autologous stem-cell transplantation in refractory autoimmune diseases after

Autoimmune diseases that are resistant to conventional treatment cause severe morbidity and even mortality. In the present study we demonstrate that complete remissions can be achieved in refractory polychondritis and systemic lupus erythematosus (SLE), even at advanced stage, with the use of autologous stem-cell transplantation (SCT). Remissions persisted after reconstitution of the immune system. In the treatment of advanced systemic sclerosis (SSc), stable disease may be achieved with autologous SCT.

Tags: autoimmune-diseases, nih, stem-cell-transplantation, systemic-lupus-erythematosus, systemic-sclerosis
Organization: U.S. Department of Health & Human Services
2022 Methodological Summary And Definitions

Use this summary report to properly interpret 2022 NSDUH estimates related to substance use, mental health, and treatment. The report accompanies theannual detailed tablesand covers overall methodology, key definitions for measures and terms used in 2022 NSDUH reports and tables, and selected analyses of the measures and how they should be interpreted.The report is organized into five chapters:Introduction.Description of the survey, including information about the sample design, data collection procedures and questionnaire changes, and key aspects of data processing such as development of the analysis weights.Technical details on the statistical methods and measurement, such as suppression criteria for unreliable estimates, statistical testing procedures, revised estimates for 2021 to account for data collection mode, and issues around selected substance use and mental health measures.Special topics related to prescription psychotherapeutic drugs.Description of other sources of data on substance use and mental health issues in the United States, including data sources for populations outside the NSDUH target population.An appendix covers key definitions used in NSDUH reports and tables.

Tags: mental-health-measures, nsduh-methodology, samhsa, statistical-methods, substance-use-definitions
Organization: U.S. Department of Health & Human Services
Detroit-Warren-Livonia, MI

This report presents combined 2005 to 2010 National Survey on Drug Use and Health (NSDUH) results for those aged 12 or older in the Detroit-Warren-Livonia, MI metro area. The report includes estimates of substance use disorder, major depressive episode, illicit drug use, marijuana use, cigarette use, binge alcohol use, and the nonmedical use of prescription-type pain relievers. Results are provided for the Detroit-Warren-Livonia metro area, Michigan, and the U.S. overall.

Tags: major-depression, michigan-health, nsduh-data, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Compound 525611: N,N-Dimethyl-N'-benzyl-p-chlorobenzamidine

Chemical compound data from PubChem database. IUPAC Name: N'-benzyl-4-chloro-N,N-dimethylbenzenecarboximidamide. Molecular Formula: C16H17ClN2. Molecular Weight: 272.77. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
San Francisco – SF Div: Drug-Related Emergency Department Visits, 2004-2011 - All Visits

Excel file with estimates, rates, relative standard errors, trends and confidence intervals for all drug-related emergency department (ED) visits in the San Francisco division of the San Francisco metropolitan area, covering 2004-2011. File includes all drug-related ED visits that are reportable to DAWN without regard for the reason for the visit or the specific drugs involved. It includes visits involving all forms of drug misuse or abuse plus visits resulting from adverse reaction, accidental ingestion, suicide attempts, and visits where patients were seeking detoxification services. These estimates are useful for looking at overall levels of drug involvement in ED visits.File includes data for over 500 drugs, including illicit drugs, prescription and over-the-counter medications, dietary supplements, inhalants and alcohol.  Includes total visits, gender, age group, race/ethnicity, outcome of visit, drug combinations, number of drugs involved in visit, drug frequency, and drugs confirmed by toxicology.Additional detail is provided for illicit drugs, psychotherapeutic drugs, central nervous system (CNS) drugs, respiratory drugs and cardiovascular drugs.

Tags: drug-related-ed-visits, emergency-department-data, samhsa, san-francisco-dawn, substance-abuse-trends
Organization: U.S. Department of Health & Human Services
More than One Third of Adults with Major Depressive Episode Did Not Talk to a Professional (2008 to 2012 NSDUH)

This spotlight presents major depressive episodes in the past year among adults aged 18 or older using 2008 to 2012 National Surveys on Drug Use and Health (NSDUHs) by whether they talked to a health or alternative service professional during the past 12 months.

Tags: adult-mental-health, major-depressive-episode, mental-health-services, nsduh-data, samhsa
Organization: U.S. Department of Health & Human Services
Compound 525559: 1-Pentanamine, N-(phenylmethylene)-

Chemical compound data from PubChem database. IUPAC Name: N-pentyl-1-phenylmethanimine. Molecular Formula: C12H17N. Molecular Weight: 175.27. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2010 State Profile — Vermont

This state profile includes data from facilities in Vermont that reported to N-SSATS for the survey reference date March 31, 2010. Data were collected on the location, characteristics, services offered, and number of clients in treatment at alcohol and drug abuse treatment facilities (both public and private) in Vermont. In Vermont, 42 substance abuse treatment facilities were included in the 2010 N-SSATS, reporting that there were 4,489 clients in substance abuse treatment on March 31, 2010. The survey response rate in Vermont was 95.7%.

Tags: alcohol-drug-abuse, n-ssats, samhsa, substance-abuse-treatment, vermont
Organization: U.S. Department of Health & Human Services
Publications Using SAMHSA DataTable 5. First Use of Marijuana among Persons Aged 12 or Older, by State and Substate Regions: Average Annual Rates Based on 2010, 2011, and 2012 NSDUHs

Publications Using SAMHSA DataTable 5. First Use of Marijuana among Persons Aged 12 or Older, by State and Substate Regions: Average Annual Rates Based on 2010, 2011, and 2012 NSDUHs

Tags: adolescent-health, marijuana-initiation, nsduh-data, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Prone positioning does not affect cannula function during extracorporeal membrane oxygenation or continuous renal replacement therapy

Introduction
          Prone positioning in respiratory failure has been shown to be a useful adjunct in the treatment of severe hypoxia. However, the prone position can result in dislodgment or malfunction of tubes and cannulae. Certain patients receiving extracorporeal membrane oxygenation (ECMO) or continuous renal replacement therapy (CRRT) may also benefit from positional therapy. The impact of cannula-related complications in these patients is potentially disastrous. The safety and efficacy of prone positioning of these patients has not been previously reported.
        
        
          Materials and methods
          A retrospective chart review evaluated ECMO or CRRT cannula location, and displacement or malfunction during positional change or while prone. The study was set in a General Surgery and Trauma Intensive Care Unit. The subjects were all patients at our institution who simultaneously underwent ECMO or CRRT and prone positioning from July 1996 to July 2001. There were no interventions.
        
        
          Results
          Ten patients underwent ECMO and 42 patients underwent CRRT during the study period. Seven patients underwent simultaneous prone positioning and either ECMO (4/10) or CRRT (4/42). A total of 68 turning events (prone to supine or supine to prone) were recorded, with each patient averaging 9.7 (range, 4–16) turning episodes. Turning was performed with sheets and extra nursing personnel; no special mechanical assist devices were used. No patients experienced inadvertent cannula removal during turning. Two patients had poor flow through their cannulae. In one patient, this occurred in the supine position and required repositioning of the cannula. In the second patient, cannulae were changed twice and flow was poor in both the supine and the prone positions. All ECMO and CRRT patients received venous cannulae. Cannula location (seven internal jugular and 11 femoral) did not the affect risk of malfunction.
        
        
          Discussion and conclusions
          Patients with venous cannulae for ECMO or CRRT can be safely placed in the prone position. Flow rates are maintained in this position. Potential cannula complications of ECMO and CRRT are not a contraindication to prone positioning in severely ill patients.

Tags: cannula-function, ecmo-crrt, nih, prone-positioning, renal-replacement
Organization: U.S. Department of Health & Human Services
2014 CMHS Uniform Reporting System (URS) Table for Georgia

2014 Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for Georgia. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: georgia-mental-health, mental-health-services, outcome-measures, samhsa, urs-data
Organization: U.S. Department of Health & Human Services
Compound 528467: 1-Tridecene, 4,8,12-trimethyl

Chemical compound data from PubChem database. IUPAC Name: 4,8,12-trimethyltridec-1-ene. Molecular Formula: C16H32. Molecular Weight: 224.42. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Publication bias in gastroenterological research – a retrospective cohort study based on abstracts submitted to a scientific meeting

Background
          The aim of this study was to examine the determinants of publication and whether publication bias occurred in gastroenterological research.
        
        
          Methods
          A random sample of abstracts submitted to DDW, the major GI meeting (1992–1995) was evaluated. The publication status was determined by database searches, complemented by a mailed survey to abstract authors. Determinants of publication were examined by Cox proportional hazards model and multiple logistic regression.
        
        
          Results
          The sample included abstracts on 326 controlled clinical trials (CCT), 336 other clinical research reports (OCR), and 174 basic science studies (BSS). 392 abstracts (47%) were published as full papers. Acceptance for presentation at the meeting was a strong predictor of subsequent publication for all research types (overall, 54% vs. 34%, OR 2.3, 95% CI 1.7 to 3.1). In the multivariate analysis, multi-center status was found to predict publication (OR 2.8, 95% CI 1.6–4.9). There was no significant association between direction of study results and subsequent publication. Studies were less likely to be published in high impact journals if the results were not statistically significant (OR 0.5, 95 CI 95% 0.3–0.6). The author survey identified lack of time or interest as the main reason for failure to publish.
        
        
          Conclusions
          Abstracts which were selected for presentation at the DDW are more likely to be followed by full publications. The statistical significance of the study results was not found to be a predictor of publication but influences the chances for high impact publication.

Tags: abstract-analysis, clinical-trials, gastroenterology-research, nih, publication-bias
Organization: U.S. Department of Health & Human Services
Compound 528490: Eicosane, 6-ethyl

Chemical compound data from PubChem database. IUPAC Name: 6-ethylicosane. Molecular Formula: C22H46. Molecular Weight: 310.6. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
ICU Cornerstone: Changing our view of blood transfusions

Blood transfusions are commonly administered to critically ill patients, but deciding when to transfuse a particular patient is often difficult and necessitates careful consideration of both the potential benefits and risks. This commentary briefly discusses some of the considerations both for and against blood transfusion in the setting of critical illness and reviews a landmark clinical trial in this area. Finally, we reflect on the changes in attitudes towards the transfusion of blood and blood products that have taken place over the last 20 years.

Tags: anemia-treatment, blood-transfusion, critical-illness, nih, transfusion-risks
Organization: U.S. Department of Health & Human Services
Compound 525056: 5-Chlorodecane

Chemical compound data from PubChem database. IUPAC Name: 5-chlorodecane. Molecular Formula: C10H21Cl. Molecular Weight: 176.72. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Carpal alignment in distal radial fractures

Background
          Carpal malalignment following the malunited distal radial fracture is described to develop as an adaptation to realign the hand to the malunion. It worsens gradually after healing of the fracture due to continued loading of the wrist. It is also reported to develop during the immobilization itself rather than after fracture healing. The present work was aimed to study the natural course and the quantitative assessment of such adaptive carpal realignment following distal radial fracture.
        
        
          Methods
          In a prospective study, 118 distal radial fractures treated with different modalities were followed-up with serial radiographs for a year for assessment of various radiological parameters.
        
        
          Results
          Two patterns of carpal malalignment were identified depending upon the effective radio-lunate flexion (ERLF) measured on pre-reduction radiographs. The midcarpal malalignment was seen in 98 radial fractures (83%) with the lunate following the dorsiflexed fracture fragment and a measured ERLF of less than 25°. The second pattern of radio-carpal malalignment showed the fracture fragment to dorsiflex without taking the lunate with a measured ERLF of more than 25°. The scaphoid did not follow the fracture fragment in both the patterns of malalignment.
        
        
          Conclusion
          It is better to assess distal radial fractures for any wrist ligamentous injury on the post-reduction film with the restored radial anatomy than on the pre-reduction film since most carpal malalignments get corrected with the reduction of the fracture. Similar carpal malalignment reappear with the redisplacement of the fracture as seen in pre-reduction radiographs and develops during the immobilization rather than as a later compensatory mechanism for the malunion.

Tags: carpal-alignment, distal-radial-fractures, nih, radiological-parameters, wrist-fractures
Organization: U.S. Department of Health & Human Services
Connecticut 2016 Potential Areas for Addressing Service Gaps for Opioid Treatment

The purpose of the medication-assisted treatment (MAT) facility maps is to identify areas on a state-by-state basis that may be potentially underserved by existing treatment facilities. The maps are created with a methodology that seeks to include the highest potential need areas from individual counties so that county-level stakeholders are also informed. The maps are meant to be used as a tool for policy makers to determine potentially underserved areas—not as a definitive representation of these areas.

Tags: connecticut-opioids, mat-access, opioid-treatment, samhsa, service-gap-analysis
Organization: U.S. Department of Health & Human Services
Compound 525599: N,N-Dimethyl-N'-(4-methoxyphenyl)-p-chlorobenzamidine

Chemical compound data from PubChem database. IUPAC Name: 4-chloro-N'-(4-methoxyphenyl)-N,N-dimethylbenzenecarboximidamide. Molecular Formula: C16H17ClN2O. Molecular Weight: 288.77. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Table 20. 2011-2012 NSDUH Dependence or Abuse of Illicit Drugs or Alcohol in the Past Year, by Age Group and State

Table 20. Dependence or Abuse of Illicit Drugs or Alcohol in the Past Year, by Age Group and State: Percentages, Annual Averages Based on 2011 and 2012 NSDUHs. Results are provided by State and for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: alcohol-dependence, drug-abuse, nsduh-data, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
2018 Uniform Reporting System (URS) Table for American Samoa

This is the 2018 Uniform Reporting System (URS) Output Tables for American Samoa. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: american-samoa, block-grant-data, mental-health-services, noms-measures, samhsa
Organization: U.S. Department of Health & Human Services