AndreaBozzo/ceres-open-data-index huggingface dataset:
Compound 525190: Undecaethylene glycol, diacetate

Chemical compound data from PubChem database. IUPAC Name: 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-acetyloxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl acetate. Molecular Formula: C26H50O14. Molecular Weight: 586.7. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Ohio, 2015

This is a behavioral health report for the state of Ohio. The report utilizes data from the National Survey on Drug Use and Health (NSDUH), and the Uniform Reporting System. The topics addressed in the report include youth substance use, youth mental health and treatment, mental health and treatment, substance use and substance use treatment.

Tags: mental-health-treatment, ohio-behavioral-health, samhsa, substance-use-ohio, youth-mental-health
Organization: U.S. Department of Health & Human Services
Compound 525268: N'-(3-ethoxy-phenyl)-N,N-dimethyl-acetamidine

Chemical compound data from PubChem database. IUPAC Name: N'-(3-ethoxyphenyl)-N,N-dimethylethanimidamide. Molecular Formula: C12H18N2O. Molecular Weight: 206.28. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 525238: Guanidine, N''-(3-chlorophenyl)-N,N,N',N'-tetramethyl-

Chemical compound data from PubChem database. IUPAC Name: 2-(3-chlorophenyl)-1,1,3,3-tetramethylguanidine. Molecular Formula: C11H16ClN3. Molecular Weight: 225.72. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
A family of putative K

Background
          Prior to this report, members of the inward rectifier family, or Kir, have been found only in eukaryotes. Like most K+ channels, the pore-forming part of the protein is formed by four identical, or closely related, subunits. Each subunit contains a transmembrane M1-P-M2 motif that is followed by a relatively large C-terminus region unique to Kir's.
        
        
          Results
          In searching unfinished microbial genomes for K+ channels, we identified five sequences in the prokaryote Burkholderia pseudomallei, Burkholderia cepacia, Burkholderia fungorum LB400, Magentospirillum magnetotacticum, and Nostoc Punctiforme genomes that code for proteins whose closest relatives in current sequence databases are eukaryote Kir's. The sequence similarity includes the C-terminus portion of Kir's, for which there are no other close homologs in current prokaryote sequences. Sequences of the pore-forming P and M2 segments of these proteins, which we call KirBac, is intermediate between those of eukaryotic Kir's and several other K+ channel families.
        
        
          Conclusions
          Although KirBac's are more closely related to Kir's than to other families of K+ channels, the intermediate nature of their pore-forming P and M2 segments suggests that they resemble an ancestral precursor to the eukaryotic Kir's. The similarity of KirBac to the bacterial KcsA channel, whose transmembrane structure has been solved, helps align Kir's with KcsA. KirBac's may assist in solving the three-dimensional structure of a member of the Kir family since bacterial membrane proteins are more easily expressed in the quantities necessary for crystallography.

Tags: ion-channels, kir-channels, nih, potassium-channels, prokaryotic-proteins
Organization: U.S. Department of Health & Human Services
2.3 Facilities, by type of care offered, and facilities with Opioid Treatment Programs: 2007-2011. Number and percent

This a National Survey of Substance Abuse Treatment Services (N-SSATS) data table showing facilities, by type of care offered, and facilities with Opioid treatments programs from 2007 to 2011.

Tags: n-ssats, opioid-treatment-programs, samhsa, substance-abuse-treatment, treatment-facilities
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Delaware, 2013

This is a behavioral health report for the state of Delaware. It uses the  National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment Services (NSSATS) to address the topics of youth substance use , youth mental health and treatment, adult mental health and treatment, substance use, and substance use treatment for the years 2008 to 2012.

Tags: adult-mental-health, delaware-behavioral-health, samhsa, substance-abuse-treatment, youth-substance-use
Organization: U.S. Department of Health & Human Services
Policy mapping for establishing a national emergency health policy for Nigeria

Background
          The number of potential life years lost due to accidents and injuries though poorly studied has resulted in tremendous economic and social loss to Nigeria. Numerous socio-cultural, economic and political factors including the current epidemic of ethnic and religious conflicts act in concert in predisposing to and enabling the ongoing catastrophe of accident and injuries in Nigeria.
        
        
          Methods
          Using the "policymaker", Microsoft-Windows® based software, the information generated on accidents and injuries and emergency health care in Nigeria from literature review, content analysis of relevant documents, expert interviewing and consensus opinion, a model National Emergency Health Policy was designed and analyzed. A major point of analysis for the policy is the current political feasibility of the policy including its opportunities and obstacles in the country.
        
        
          Results
          A model National Emergency Health Policy with policy goals, objectives, programs and evaluation benchmarks was generated. Critical analyses of potential policy problems, associated multiple players, diverging interests and implementation guidelines were developed.
        
        
          Conclusions
          "Political health modeling" a term proposed here would be invaluable to policy makers and scholars in developing countries in assessing the political feasibility of policy managing. Political modeling applied to the development of a NEHP in Nigeria would empower policy makers and the policy making process and would ensure a sustainable emergency health policy in Nigeria.

Tags: emergency-health-policy, health-policy-analysis, injury-prevention, nigeria, nih
Organization: U.S. Department of Health & Human Services
Compound 528398: Butanamine, 2-methyl-N-(3-methylbutylidene)

Chemical compound data from PubChem database. IUPAC Name: 3-methyl-N-(2-methylbutyl)butan-1-imine. Molecular Formula: C10H21N. Molecular Weight: 155.28. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Ileal mucosal bile acid absorption is increased in Cftr knockout mice

Background
          Excessive loss of bile acids in stool has been reported in patients with cystic fibrosis. Some data suggest that a defect in mucosal bile acid transport may be the mechanism of bile acid malabsorption in these individuals. However, the molecular basis of this defect is unknown. This study examines the expression of the ileal bile acid transporter protein (IBAT) and rates of diffusional (sodium independent) and active (sodium dependent) uptake of the radiolabeled bile acid taurocholate in mice with targeted disruption of the cftr gene.
        
        
          Methods
          Wild-type, heterozygous cftr (+/-) and homozygous cftr (-/-) mice were studied. Five one-cm segments of terminal ileum were excised, everted and mounted onto thin stainless steel rods and incubated in buffer containing tracer 3H-taurocholate. Simultaneously, adjacent segments of terminal ileum were taken and processed for immunohistochemistry and Western blots using an antibody against the IBAT protein.
        
        
          Results
          In all ileal segments, taurocholate uptake rates were fourfold higher in cftr (-/-) and two-fold higher in cftr (+/-) mice compared to wild-type mice. Passive uptake was not significantly higher in cftr (-/-) mice than in controls. IBAT protein was comparably increased. Immuno-staining revealed that the greatest increases occurred in the crypts of cftr (-/-) animals.
        
        
          Conclusions
          In the ileum, IBAT protein densities and taurocholate uptake rates are elevated in cftr (-/-) mice > cftr (+/-) > wild-type mice. These findings indicate that bile acid malabsorption in cystic fibrosis is not caused by a decrease in IBAT activity at the brush border. Alternative mechanisms are proposed, such as impaired bile acid uptake caused by the thick mucus barrier in the distal small bowel, coupled with a direct negative regulatory role for cftr in IBAT function.

Tags: bile-acid-absorption, cftr-knockout-mice, cystic-fibrosis, ibat-transporter, nih
Organization: U.S. Department of Health & Human Services
2016-2018 NSDUH Substate Region Definitions

Use these maps and tables to understand the geographic boundaries used in the2016-2018 National Surveys on Drug Use and Health (NSDUH) substate estimates. The resource is available as a PDF or HTM file. There is also additional documentation in SAS and Excel.

Tags: geographic-boundaries, mental-health-service-areas, nsduh-geography, samhsa, substate-regions
Organization: U.S. Department of Health & Human Services
Compound 525110: 2,3-Dichloropropyl isopentanoate

Chemical compound data from PubChem database. IUPAC Name: 2,3-dichloropropyl 3-methylbutanoate. Molecular Formula: C8H14Cl2O2. Molecular Weight: 213.1. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Leukocyte trafficking in alveoli and airway passages

Many pulmonary diseases preferentially affect the large airways or the alveoli. Although the mechanisms are often particular to each disease process, site-specific differences in leukocyte trafficking and the regulation of inflammation also occur. Differences in the process of margination, sequestration, adhesion, and migration occur that can be attributed to differences in anatomy, hemodynamics, and the expression of proteins. The large airways are nourished by the bronchial circulation, whereas the pulmonary circulation feeds the distal lung parenchyma. The presence of different cell types in large airways from those in alveoli might contribute to site-specific differences in the molecular regulation of the inflammatory process.

Tags: airway-inflammation, alveoli, leukocyte-trafficking, nih, pulmonary-inflammation
Organization: U.S. Department of Health & Human Services
Classification and evolutionary history of the single-strand annealing proteins, RecT, Redβ, ERF and RAD52

Background
          The DNA single-strand annealing proteins (SSAPs), such as RecT, Redβ, ERF and Rad52, function in RecA-dependent and RecA-independent DNA recombination pathways. Recently, they have been shown to form similar helical quaternary superstructures. However, despite the functional similarities between these diverse SSAPs, their actual evolutionary affinities are poorly understood.
        
        
          Results
          Using sensitive computational sequence analysis, we show that the RecT and Redβ proteins, along with several other bacterial proteins, form a distinct superfamily. The ERF and Rad52 families show no direct evolutionary relationship to these proteins and define novel superfamilies of their own. We identify several previously unknown members of each of these superfamilies and also report, for the first time, bacterial and viral homologs of Rad52. Additionally, we predict the presence of aberrant HhH modules in RAD52 that are likely to be involved in DNA-binding. Using the contextual information obtained from the analysis of gene neighborhoods, we provide evidence of the interaction of the bacterial members of each of these SSAP superfamilies with a similar set of DNA repair/recombination protein. These include different nucleases or Holliday junction resolvases, the ABC ATPase SbcC and the single-strand-binding protein. We also present evidence of independent assembly of some of the predicted operons encoding SSAPs and in situ displacement of functionally similar genes.
        
        
          Conclusions
          There are three evolutionarily distinct superfamilies of SSAPs, namely the RecT/Redβ, ERF, and RAD52, that have different sequence conservation patterns and predicted folds. All these SSAPs appear to be primarily of bacteriophage origin and have been acquired by numerous phylogenetically distant cellular genomes. They generally occur in predicted operons encoding one or more of a set of conserved DNA recombination proteins that appear to be the principal functional partners of the SSAPs.

Tags: dna-recombination, nih, protein-evolution, rect-red-erf-rad52, single-strand-annealing
Organization: U.S. Department of Health & Human Services
Oklahoma (OK)

This report presents Oklahoma\'s estimates for 25 measures of substance use and mental health based on the combined 2009 and 2010 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for Oklahoma for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: mental-health, oklahoma-survey, samhsa, serious-mental-illness, substance-use
Organization: U.S. Department of Health & Human Services
Compound 528562: 7-Methyltricosane

Chemical compound data from PubChem database. IUPAC Name: 7-methyltricosane. Molecular Formula: C24H50. Molecular Weight: 338.7. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
High-susceptibility of photosynthesis to photoinhibition in the tropical plant

Background
          The tropical plant Ficus microcarpa L. f. cv. Golden Leaves (GL) is a high-light sensitive tropical fig tree in which sun-leaves are yellow and shade-leaves are green. We compared the response of photosynthetic activities to strong light between GL and its wild-type (WT, Ficus microcarpa L. f.).
        
        
          Results
          Field measurements of maximum photosystem II (PSII) efficiency (Fv/Fm) of intact sun-leaves in GL showed that photo synthetic activity was severely photoinhibited during the daytime (Fv/Fm = 0.46) and subsequently recovered in the evening (Fv/Fm = 0.76). In contrast, WT did not show any substantial changes of Fv/Fm values throughout the day (between 0.82 and 0.78). Light dependency of the CO2 assimilation rate in detached shade-leaves of GL showed a response similar to that in WT, suggesting no substantial difference in photosynthetic performance between them. Several indicators of photoinhibition, including declines in PSII reaction center protein (D1) content, Fv/Fm value, and O2 evolution and CO2 assimilation rates, all indicated that GL is much more susceptible to photoinhibition than WT. Kinetics of PAM chlorophyll a fluorescence revealed that nonphotochemical quenching (NPQ) capacity of GL was lower than that of WT.
        
        
          Conclusion
          We conclude that the photosynthetic apparatus of GL is more highly susceptible to photoinhibition than that of WT.

Tags: ficus-microcarpa, nih, photosynthesis-photoinhibition, photosystem-ii-efficiency, plant-physiology
Organization: U.S. Department of Health & Human Services
Delta Opioid activation of the Mitogen-activated protein kinase cascade does not require transphosphorylation of Receptor Tyrosine Kinases

Background
          In this study, we investigated the mechanism(s) by which delta opioids induce their potent activation of extracellular signal-regulated protein kinases (ERKs) in different cell lines expressing the cloned δ-opioid receptor (δ-OR). While it has been known for some time that OR stimulation leads to the phosphorylation of both ERK isoforms, the exact progression of events has remained elusive.
        
        
          Results
          Our results indicate that the transphosphorylation of an endogenous epidermal growth factor receptor (EGFR) in the human embryonic kidney (HEK-293) cell line does not occur when co-expressed δ-ORs are stimulated by the δ-opioid agonist, D-Ser-Leu-enkephalin-Thr (DSLET). Moreover, neither pre-incubation of cultures with the selective EGFR antagonist, AG1478, nor down-regulation of the EGFR to a point where EGF could no longer activate ERKs had an inhibitory effect on ERK activation by DSLET. These results appear to rule out any structural or catalytic role for the EGFR in the δ-opioid-mediated MAPK cascade. To confirm these results, we used C6 glioma cells, a cell line devoid of the EGFR. In δ-OR-expressing C6 glioma cells, opioids produce a robust phosphorylation of ERK 1 and 2, whereas EGF has no stimulatory effect. Furthermore, antagonists to the RTKs that are endogenously expressed in C6 glioma cells (insulin receptor (IR) and platelet-derived growth factor receptor (PDGFR)) were unable to reduce opioid-mediated ERK activation.
        
        
          Conclusion
          Taken together, these data suggest that the transactivation of resident RTKs does not appear to be required for OR-mediated ERK phosphorylation and that the tyrosine-phosphorylated δ-OR, itself, is likely to act as its own signalling scaffold.

Tags: delta-opioid-receptor, dslet-agonist, erk-phosphorylation, nih, signal-transduction
Organization: U.S. Department of Health & Human Services
Sample Size and Population Estimates Tables (Standard Errors and P Values) - 8.1 to 8.13

These detailed tables show standard errors for sample sizes and population estimates from the 2011 National Survey on Drug Use and Health (NSDUH). Standard errors for samples sizes and population estimates are provided by age group, gender, race/ethnicity, education level, employment status, geographic area, pregnancy status, college enrollment status, and probation/parole status.

Tags: drug-use-survey, nsduh-2011, population-estimates, samhsa, standard-errors
Organization: U.S. Department of Health & Human Services
2022 Uniform Reporting System (URS) Table For Missouri

This is the 2022 Uniform Reporting System (URS) Output Tables for Missouri. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-data, mental-health-services, missouri, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Child and Family Services Reviews Update: Volume 8, Issue 2, April 2016

This issue of Child and Family Services Reviews Update contains the following sections: Enhancements to the Online Monitoring System, Preparing for Upcoming CFSRs, FAQs on the CFSR Information Portal, and Now in Spanish: Onsite Review Instrument and Instructions.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: assessment, child, policy, reporting, social
Organization: U.S. Department of Health & Human Services
Compound 528524: Hexadecane, 5-pentyl

Chemical compound data from PubChem database. IUPAC Name: 6-butylheptadecane. Molecular Formula: C21H44. Molecular Weight: 296.6. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Arizona: 2011-2012 NSDUH

This report presents Arizona\'s estimates for 25 measures of substance use and mental health based on the combined 2011 and 2012 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided by State and for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: arizona-nsduh, mental-health, samhsa, serious-mental-illness, substance-use
Organization: U.S. Department of Health & Human Services
2011 CMHS Uniform Reporting System (URS) Output Tables for Idaho

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2011. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-program, community-mental-health, mental-health-services, outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Alabama, 2014

This is a behavioral health report for the United States. The report utilizes data from the National Survey on Drug Use and Health (NSDUH), the Youth and Risk Behavior Survey (YRBS), the Monitoring of the Future Survey sponsored by the National Institute on Drug Abuse and findings by the Center for Medicare & Medicaid Services about the use of mental health and substance use treatment services by medicare recipients. The topics address in the report include youth substance use, youth mental health and treatment, adult mental health and treatment, substance use, substance use treatment, and medicare enrollees for the years 2009 to 2013.

Tags: alabama, behavioral-health, mental-health, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
2021 Uniform Reporting System (URS) Table For Oklahoma

This is the 2021 Uniform Reporting System (URS) Output Tables for Oklahoma. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-data, mental-health-services, oklahoma, outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services