AndreaBozzo/ceres-open-data-index huggingface dataset:
Quality Assessment of the 2014 to 2019 NSDUH Public Use Files

Explore the data quality of the 2014-2019 National Survey on Drug Use and Health (NSDUH) Public Use Files (PUFs) and its comparability with the NSDUH Restricted Use Files (RUFs). This report demonstrates the overall quality of the NSDUH PUFs and the statistical disclosure control techniques used to create them.Chapters:Describes NSDUH and lays out the objective of the report.Presents an overview of the NSDUH disclosure concerns, briefly discusses the disclosure technique known as Micro Agglomeration, Substitution, Subsampling, and Calibration (MASSC), and provides a summary of this study’s quality assessment and research methods.Discusses how some of the detailed tables based on RUF data were selected and replicated using PUF data.Describes the data quality assessment results and findings.Summarizes the conclusions.There are also five appendices that support the analysis further.Aprevious reportanalyzed the PUF data from 2002-2013.

Tags: mental-health, nsduh-puf, samhsa, substance-use, survey-data-quality
Organization: U.S. Department of Health & Human Services
Regional Partnership Grants National Cross-Site Evaluation (RPG-4)

To address the far-reaching consequences of adult substance use disorders on families and children, Congress authorized competitive grants to support partnerships among child welfare, substance abuse treatment, and related organizations. Children’s Bureau (CB) within the Administration for Children and Families, Administration on Children, Youth, and Families at the U.S. Department of Health and Human Services established the Regional Partnership Grant (RPG) program to implement programs to meet the needs of this target population.

CB funded Mathematica, along with its subcontractor Walter R. MacDonald & Associates (WRMA), to conduct a cross-site evaluation of the grantees’ RPG projects. Mathematica/WRMA designed a cross-site evaluation to address the following research questions: 

1. Which partners were involved in each RPG project and how did they work together?
2. How much progress did RPG4 projects make toward interagency collaboration and service coordination?
3. How did the child welfare and substance use treatment agencies work together to achieve the goals of RPG?
4. What referral sources did RPG projects use? Did referral sources change over time?
5. What are the characteristics of families who enrolled in RPG?
6. To what extent did RPG projects reach their target populations?
7. What core services were provided and to whom?
8. Were core services that families received different from the services proposed in grantee applications? If so, what led to the changes in planned services?
9. How engaged were participants with the services provided?
10. Which agencies (grantees and their partners) provided services?
11. What proportion of families exited RPG?
12. What plans and activities did RPG projects undertake to maintain the implementation infrastructure and processes during and after the grant period?
13. What plans and activities did RPG projects undertake to maintain the organizational infrastructure and processes after the grant period?
14. To what extent were RPG projects prepared to sustain services after the grant period?
15. What plans and activities did RPG projects undertake to develop funding strategies and secure resources needed after the grant period?
16. How did the federal, state, and local context affect RPG projects and their efforts to sustain RPG services?
17. What were the well-being, permanency, safety, recovery, and family functioning outcomes for children and adults who enrolled in RPG projects? 
18. What were the impacts of RPG projects on children and adults who enrolled in RPG?

The cross site evaluation uses several data sources to answer these research questions: (1) a partner study, (2) enrollment and services data, (3) outcomes data, and (4) site visits.

Investigators: Sarah Avellar, Ph.D., Mathematica, Washington, DC
Angela D'Angelo, Ph.D., Mathematica, Chicago
Elizabeth C. Weigensberg, Ph.D., Mathematica, Chicago
Juliette Henke, MPP, Mathematica, Princeton
Yange Xue, Ph.D., Mathematica, Princeton

Tags: abuse, care, ndacan, policy, reporting
Organization: U.S. Department of Health & Human Services
A database for the provisional identification of species using only genotypes: web-based genome profiling

Background
          For a long time one could not imagine being able to identify species on the basis of genotype only as there were no technological means to do so. But conventional phenotype-based identification requires much effort and a high level of skill, making it almost impossible to analyze a huge number of organisms, as, for example, in microbe-related biological disciplines. Comparative analysis of 16S rRNA has been changing the situation, however. We report here an approach that will allow rapid and accurate phylogenetic comparison of any unknown strain to all known type strains, enabling tentative assignments of strains to species. The approach is based on two main technologies: genome profiling and Internet-based databases.
        
        
          Results
          A complete procedure for provisional identification of species using only their genomes is presented, using random polymerase chain reaction, temperature-gradient gel electrophoresis, image processing to generate 'species-identification dots' (spiddos) and data processing. A database website for this purpose was also constructed and operated successfully. The protocol was standardized to make the system reproducible and reliable. The overall methodology thus established has remarkable aspects in that it enables non-experts to obtain an initial species identification without a lot of effort and is self-developing; that is, species can be determined more definitively as the database is used more and accumulates more genome profiles.
        
        
          Conclusions
          We have devised a methodology that enables provisional identification of species on the basis of their genotypes only. It is most useful for microbe-related disciplines as they face the most serious difficulties in species identification.

Tags: 16s-rrna, genome-profiling, genotype-analysis, nih, species-identification
Organization: U.S. Department of Health & Human Services
The effect on endothelial function of vitamin C during methionine induced hyperhomocysteinaemia

Background
          Manipulation of total homocysteine concentration with oral methionine is associated with impairment of endothelial-dependent vasodilation. This may be caused by increased oxidative stress. Vitamin C is an aqueous phase antioxidant vitamin and free radical scavenger. We hypothesised that if the impairment of endothelial function related to experimental hyperhomocysteinaemia was free radically mediated then co-administration of vitamin C should prevent this.
        
        
          Methods
          Ten healthy adults took part in this crossover study. Endothelial function was determined by measuring forearm blood flow (FBF) in response to intra-arterial infusion of acetylcholine (endothelial-dependent) and sodium nitroprusside (endothelial-independent). Subjects received methionine (100 mg/Kg) plus placebo tablets, methionine plus vitamin C (2 g orally) or placebo drink plus placebo tablets. Study drugs were administered at 9 am on each study date, a minimum of two weeks passed between each study. Homocysteine (tHcy) concentration was determined at baseline and after 4 hours. Endothelial function was determined at 4 hours. Responses to the vasoactive substances are expressed as the area under the curve of change in FBF from baseline. Data are mean plus 95% Confidence Intervals.
        
        
          Results
          Following oral methionine tHcy concentration increased significantly versus placebo. At this time endothelial-dependent responses were significantly reduced compared to placebo (31.2 units [22.1-40.3] vs. 46.4 units [42.0-50.8], p < 0.05 vs. Placebo). Endothelial-independent responses were unchanged. Co-administration of vitamin C did not alter the increase in homocysteine or prevent the impairment of endothelial-dependent responses (31.4 [19.5-43.3] vs. 46.4 units [42.0-50.8], p < 0.05 vs. Placebo)
        
        
          Conclusions
          This study demonstrates that methionine increased tHcy with impairment of the endothelial-dependent vasomotor responses. Administration of vitamin C did not prevent this impairment and our results do not support the hypothesis that the endothelial impairment is mediated by adverse oxidative stress.

Tags: endothelial-function, forearm-blood-flow, hyperhomocysteinemia, nih, vitamin-c
Organization: U.S. Department of Health & Human Services
2016 Uniform Reporting System (URS) Table for Minnesota

This is the 2016 Uniform Reporting System (URS) Output Tables for Minnesota. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-program, mental-health-services, national-outcome-measures, samhsa, substance-abuse-mental-health
Organization: U.S. Department of Health & Human Services
Publications Using SAMHSA Data2011 CMHS Uniform Reporting System (URS) Output Tables for New Hampshire

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2011. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: cmhs-block-grant, mental-health-services, national-outcome-measures, samhsa, urs-data
Organization: U.S. Department of Health & Human Services
2017 Uniform Reporting System (URS) Table for Pennsylvania

This is the 2017 Uniform Reporting System (URS) Output Tables for Pennsylvania. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, evidence-based-practices, mental-health-services, outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Compound 527315: Methyl 2-[3-fluoro-4-(4-methoxyphenyl)phenyl]propanoate

Chemical compound data from PubChem database. IUPAC Name: methyl 2-[3-fluoro-4-(4-methoxyphenyl)phenyl]propanoate. Molecular Formula: C17H17FO3. Molecular Weight: 288.31. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Phoenix: Drug-Related Emergency Department Visits, 2004-2011 - Underage Drinking

Excel file with estimates, rates, relative standard errors, trends and confidence intervals for all drug-related emergency department (ED) visits involving underage drinking in the Phoenix metropolitan area, covering 2004-2011.  Underage drinking includes ED visits that involve alcohol use (alone or with other drugs) for patients under the age of 21.

Tags: drug-related-visits, emergency-department, phoenix-metro-area, samhsa, underage-drinking
Organization: U.S. Department of Health & Human Services
Role of CD28/B7 costimulation and IL-12/IL-10 interaction in the radiation-induced immune changes

Background
          The present paper aims at studying the role of B7/CD28 interaction and related cytokine production in the immunological changes after exposure to different doses of ionizing radiation.
        
        
          Results
          The stimulatory effect of low dose radiation (LDR) on the proliferative response of lymphocytes to Con A was found to require the presence of APCs. The addition of APCs obtained from both low- and high-dose-irradiated mice to splenic lymphocytes separated from low-dose-irradiated mice caused stimulation of lymphocyte proliferation. B7-1/2 expression on APCs was up-regulated after both low and high doses of radiation. There was up-regulation of CD28 expression on splenic and thymic lymphocytes after LDR and its suppression after high dose radiation (HDR), and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) expression showed changes in the opposite direction. IL-12 secretion by macrophages was stimulated after both low and high doses of radiation, but IL-10 synthesis by splenocytes was suppressed by low dose radiation and up-regulated by high dose radiation.
        
        
          Conclusion
          The status of CD28/CTLA-4 expression on T lymphocytes in the presence of up-regulated B7 expression on APCs determined the outcome of the immune changes in response to radiation, i.e., up-regulation of CD28 after LDR resulted in immunoenhancement, and up-regulation of CTLA-4 associated with down-regulation of CD28 after HDR led to immunosuppression. Both low and high doses of radiation up-regulated B7-1/2 expression on APCs. After LDR, the stimulated proliferative effect of increased IL-12 secretion by APCs, reinforced by the suppressed secretion of IL-10, further strengthened the intracellular signaling induced by B7-CD28 interaction.

Tags: cd28-costimulation, il-12-il-10, immune-response, nih, radiation-exposure
Organization: U.S. Department of Health & Human Services
NSDUH Data Spotlight: Adolescent Substance Nonuse

Find data on the nonuse of substances among adolescents aged 12 to 17 from the 2023 National Survey on Drug Use and Health (NSDUH). Estimates include illicit drugs, alcohol, tobacco products, and nicotine vaping.

Tags: adolescent-substance-use, nsduh-data, samhsa, substance-nonuse, youth-drug-use
Organization: U.S. Department of Health & Human Services
Complex splicing pattern generates great diversity in human

Background
          Mutation analysis of the neurofibromatosis type 1 (NF1) gene has shown that about 30% of NF1 patients carry a splice mutation resulting in the production of one or several shortened transcripts. Some of these transcripts were also found in fresh lymphocytes of healthy individuals, albeit typically at a very low level. Starting from this initial observation, we were interested to gain further insight into the complex nature of NF1 mRNA processing.
        
        
          Results
          We have used a RT-PCR plasmid library based method to identify novel NF1 splice variants. Several transcripts were observed with specific insertions/deletions and a survey was made. This large group of variants detected in one single gene allows to perform a comparative analysis of the factors involved in splice regulation. Exons that are prone to skipping were systematically analysed for 5' and 3' splice site strength, branch point strength and secondary structure.
        
        
          Conclusion
          Our study revealed a complex splicing pattern, generating a great diversity in NF1 transcripts. We found that, on average, exons that are spliced out in part of the mRNA have significantly weaker acceptor sites. Some variants identified in this study could have distinct roles and might expand our knowledge of neurofibromin.

Tags: neurofibromatosis-type-1, nf1-gene, nih, rt-pcr, splice-variants
Organization: U.S. Department of Health & Human Services
Compound 525463: 3-Thia-5-hexene-1-thiol

Chemical compound data from PubChem database. IUPAC Name: 2-prop-2-enylsulfanylethanethiol. Molecular Formula: C5H10S2. Molecular Weight: 134.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 525664: p-Bromobenzylidene-(4-nitrophenyl)-amine

Chemical compound data from PubChem database. IUPAC Name: 1-(4-bromophenyl)-N-(4-nitrophenyl)methanimine. Molecular Formula: C13H9BrN2O2. Molecular Weight: 305.13. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Pharmacological basis for the therapy of pain and inflammation with nonsteroidal anti-inflammatory drugs

Nonsteroidal anti-inflammatory drugs (NSAIDs) belong to the most frequently used drugs. The discovery of an inducible isoform of cyclo-oxygenase (COX-2) has led to an intensive worldwide search and the introduction of selective COX-2 inhibitors. In this review, recent advances in understanding the mechanism of action of NSAIDs and, in this context, clinical findings on NSAID-induced gastrointestinal side effects are summarized. This knowledge is important for the effective treatment of pain and inflammation, as well as for preventing serious and sometimes lethal gastrointestinal side effects.

Tags: cox-2-inhibitors, gastrointestinal-effects, nih, nsaid-therapy, pain-inflammation
Organization: U.S. Department of Health & Human Services
Preneoplastic lesions of the lung

Lung cancer is the leading cause of cancer deaths worldwide. If we can define and detect preneoplastic lesions, we might have a chance of improving survival. The World Health Organization has defined three preneoplastic lesions of the bronchial epithelium: squamous dysplasia/carcinoma in situ; atypical adenomatous hyperplasia; and diffuse idiopathic pulmonary neuroendocrine cell hyperplasia. These lesions are believed to progress to squamous cell carcinoma, adenocarcinoma and carcinoid tumors, respectively. In this review we summarize the data supporting the preneoplastic nature of these lesions, and delve into some of the genetic changes found in atypical adenomatous hyperplasia and squamous dysplasia/carcinoma in situ.

Tags: bronchial-epithelium, carcinogenesis, lung-cancer, nih, preneoplastic-lesions
Organization: U.S. Department of Health & Human Services
NSDUH: 2013 Dress Rehearsal Final Report

This report summarizes the data collection and analytic methods and results for the 2013 Dress Rehearsal (DR) for the National Survey on Drug Use and Health (NSDUH).  The 2013 DR tested revisions to the NSDUH respondent materials, questionnaire, procedures, and equipment associated with the 2015 partial redesign goals.

Tags: drug-use, mental-health, samhsa, substance-abuse, survey-methods
Organization: U.S. Department of Health & Human Services
Sequence permutations in the molecular evolution of DNA methyltransferases

Background
          DNA methyltransferases (MTases), unlike MTases acting on other substrates, exhibit sequence permutation. Based on the sequential order of the cofactor-binding subdomain, the catalytic subdomain, and the target recognition domain (TRD), several classes of permutants have been proposed. The majority of known DNA MTases fall into the α, β, and γ classes. There is only one member of the ζ class known and no members of the δ and ε classes have been identified to date. Two mechanisms of permutation have been proposed: one involving gene duplication and in-frame fusion, and the other involving inter- and intragenic shuffling of gene segments.
        
        
          Results
          Two novel cases of sequence permutation in DNA MTases implicated in restriction-modification systems have been identified, which suggest that members of the δ and ζ classes (M.MwoI and M.TvoORF1413P, respectively) evolved from β-class MTases. This is the first identification of the δ-class MTase and the second known ζ-class MTase (the first ζ-class member among DNA:m4C and m6A-MTases).
        
        
          Conclusions
          Fragmentation of a DNA MTase gene may result from attack of nucleases, for instance when the RM system invades a new cell. Its reassembly into a functional form, the order of motifs notwithstanding, may be strongly selected for, if the cognate ENase gene remains active and poses a threat to the host's chromosome. The "cut-and-paste" mechanism is proposed for β-δ permutation, which is non-circular and involves relocation of one segment of a gene. The circular β-ζ permutation may be explained both by gene duplication or shuffling of gene fragments. These two mechanisms are not mutually exclusive and probably both played a role in the evolution of permuted DNA MTases.

Tags: dna-methyltransferases, molecular-evolution, nih, restriction-modification, sequence-permutation
Organization: U.S. Department of Health & Human Services
Immunodepression in the surgical patient and increased susceptibility to infection

Multiple organ failure is the major problem in intensive care patients. The failure of the organ 'immune system' is frequently overlooked, however. In this issue the article by Angele and Faist provides an excellent review of the topic. Deactivation of monocyte and lymphocyte functions seems to play a key role in post-traumatic immunodepression. To accompany that review we summarize our knowledge of the mechanisms of deactivation. Stress response, lipopolysaccharide translocalization and tissue injury contribute to 'immunoparalysis'. Recently developed, well standardized assays now allow us to monitor the immune system like other organ functions and opens new approaches for therapeutic interventions.

Tags: monocyte-lymphocyte-function, nih, post-traumatic-immunosuppression, surgical-immunodepression, surgical-patients
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Wisconsin, 2014

This is a behavioral health report for the state of Wisconsin. It uses the  National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment Services (NSSATS) to address the topics of youth substance use , youth mental health and treatment, adult mental health and treatment, substance use, substance use treatment, and medicare enrollees for the years 2009 to 2013.

Tags: behavioral-health, mental-health, samhsa, substance-use, wisconsin
Organization: U.S. Department of Health & Human Services