AndreaBozzo/ceres-open-data-index huggingface dataset:
A human RNA polymerase II subunit is encoded by a recently generated multigene family

Background
          The sequences encoding the yeast RNA polymerase II (RPB) subunits are single copy genes.
        
        
          Results
          While those characterized so far for the human (h) RPB are also unique, we show that hRPB subunit 11 (hRPB11) is encoded by a multigene family, mapping on chromosome 7 at loci p12, q11.23 and q22. We focused on two members of this family, hRPB11a and hRPB11b: the first encodes subunit hRPB11a, which represents the major RPB11 component of the mammalian RPB complex ; the second generates polypeptides hRPB11bα and hRPB11bβ through differential splicing of its transcript and shares homologies with components of the hPMS2L multigene family related to genes involved in mismatch-repair functions (MMR). Both hRPB11a and b genes are transcribed in all human tissues tested. Using an inter-species complementation assay, we show that only hRPB11bα is functional in yeast. In marked contrast, we found that the unique murine homolog of RPB11 gene maps on chromosome 5 (band G), and encodes a single polypeptide which is identical to subunit hRPB11a.
        
        
          Conclusions
          The type hRPB11b gene appears to result from recent genomic recombination events in the evolution of primates, involving sequence elements related to the MMR apparatus.

Tags: gene-expression, multigene-family, nih, rna-polymerase-ii, transcription-regulation
Organization: U.S. Department of Health & Human Services
2023 Uniform Reporting System (URS) Table For Montana

This is the 2023 Uniform Reporting System (URS) Output Tables for Montana. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, evidence-based-practices, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Compound 525116: 3-Chloropropyl isobutyrate

Chemical compound data from PubChem database. IUPAC Name: 3-chloropropyl 2-methylpropanoate. Molecular Formula: C7H13ClO2. Molecular Weight: 164.63. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Tribal Federal Medical Assistance Percentage Reference Table for FY 2023

This report provides the Federal Medical Assistance Percentages (FMAPs) for fiscal year 2023 as well as relevant per capita income data for tribes expressing interest in operating title IV-E programs.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: affair, data, fiscal, policy, social
Organization: U.S. Department of Health & Human Services
4.12a Facilities offering services in sign language for the hearing impaired and in languages other than English, by facility operation and primary focus of facility: 2010. Numberv

This is a National Survey of Substance Abuse Treatment Services (N-SSATS) data table showing facilities offering services in sign language for the hearing impaired and in languages other than English, by facility operation and primary focus of facility in 2010. N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 States, the District of Columbia, and other U.S. jurisdictions.

Tags: hearing-impaired, language-access, samhsa, sign-language-services, substance-abuse-treatment
Organization: U.S. Department of Health & Human Services
2018-2020 NSDUH Substate Region Definitions

Substate estimates for these years are no longer available due to methodological concerns with combining 2020 data with data from 2018 and 2019. We apologize for any inconvenience or confusion this may cause.Because of the COVID-19 pandemic, most respondents answered the survey via the web in Quarter 4 of 2020, even though all responses in Quarter 1 were from in-person interviews. It is known that people may respond to the survey differently while taking it online, thus introducing what is called a mode effect.When the state estimates were released, it was assumed that the mode effect was similar for different groups of people. However, later analyses have shown that this assumption should not be made. Because of these analyses, along with concerns about the rapid societal changes in 2020, it was determined that averages across the three years could be misleading.For more detail on this decision, see the 2018-2020substate data page.

Tags: data-quality, mental-health, samhsa, substance-use, survey-methodology
Organization: U.S. Department of Health & Human Services
Affordability Most Frequent Reason for Not Receiving Mental Health Services (2009 to 2011 NSDUH)

This report uses 2009 to 2011 National Survey on Drug Use and Health (NSDUH) to assess reasons for not receiving mental health services among adults aged 18 or older with an unmet need for mental health care. Reasons for not getting care included cost/insurance, low perceived need; structural barriers; stigma; and thinking services would not help. Results are shown by age group.

Tags: cost-of-care, mental-health-access, nsduh-data, samhsa, unmet-mental-health-need
Organization: U.S. Department of Health & Human Services
Expression of ionotropic glutamate receptors in the retina of the

Background
          The expression of retinal CaMKII is up-regulated in the retina of the rdta mouse in which rod photoreceptors are genetically ablated. As ionotropic glutamate receptors are known substrates of CAMKII, this study set out to determine if the protein levels of ionotropic glutamate receptors in the rdta mouse retina are also affected.
        
        
          Results
          The NMDA receptor subunits (NR1, NR2A/B) and the GluR1; AMPA receptor subunit (GluR1) were examined in immunolabeled western blots. The results demonstrate that the amounts of NR1 and NR2A/B receptor subunits are significantly increased in crude synaptic membrane fractions isolated from retinae of the rdta mice when compared to their normal, littermate controls. The GluR1 receptor subunit and its phosphorylation are simultaneously increased in retinae of the rdta mice.
        
        
          Conclusions
          These data indicate that the NMDA receptors and AMPA (GluR1) receptors are altered in the retinae of rdta mice that lack rod photoreceptors. Because the rods are lost at an early stage in development, it is likely that these results are indicative of synaptic reorganization in the retina.

Tags: glutamate-receptors, immunoblotting, nih, rdta-mouse, retinal-degeneration
Organization: U.S. Department of Health & Human Services
CFEOM1, the classic familial form of congenital fibrosis of the extraocular muscles, is genetically heterogeneous but does not result from mutations in

Background
          To learn about the molecular etiology of strabismus, we are studying the genetic basis of 'congenital fibrosis of the extraocular muscles' (CFEOM). These syndromes are characterized by congenital restrictive ophthalmoplegia affecting muscles in the oculomotor and trochlear nerve distribution. Individuals with the classic form of CFEOM are born with bilateral ptosis and infraducted globes. When all affected members of a family have classic CFEOM, we classify the family as a CFEOM1 pedigree. We have previously determined that a CFEOM1 gene maps to the FEOM1 locus on chromosome 12cen. We now identify additional pedigrees with CFEOM1 to determine if the disorder is genetically heterogeneous and, if so, if any affected members of CFEOM1 pedigrees or sporadic cases of classic CFEOM harbor mutations in ARIX, the CFEOM2 disease gene.
        
        
          Results
          Eleven new CFEOM1 pedigrees were identified. All demonstrated autosomal dominant inheritance, and nine were consistent with linkage to FEOM1. Two small CFEOM1 families were not linked to FEOM1, and both were consistent with linkage to FEOM3. We screened two CFEOM1 families consistent with linkage to FEOM2 and 5 sporadic individuals with classic CFEOM and did not detect ARIX mutations.
        
        
          Conclusions
          The phenotype of two small CFEOM1 families does not map to FEOM1, establishing genetic heterogeneity for this disorder. These two families may harbor mutations in the FEOM3 gene, as their phenotype is consistent with linkage to this locus. Thus far, we have not identified ARIX mutations in any affected members of CFEOM1 pedigrees or in any sporadic cases of classic CFEOM.

Tags: cfeom1, extraocular-muscles, genetic-heterogeneity, nih, ophthalmoplegia
Organization: U.S. Department of Health & Human Services
Publications Using SAMHSA DataMiami - Dade Div: Drug-Related Emergency Department Visits, 2004-2011 - All Visits

Excel file with estimates, rates, relative standard errors, trends and confidence intervals for all drug-related emergency department (ED) visits in the Dade County division of the Miami metropolitan area, covering 2004-2011. File includes all drug-related ED visits that are reportable to DAWN without regard for the reason for the visit or the specific drugs involved. It includes visits involving all forms of drug misuse or abuse plus visits resulting from adverse reaction, accidental ingestion, suicide attempts, and visits where patients were seeking detoxification services. These estimates are useful for looking at overall levels of drug involvement in ED visits.File includes data for over 500 drugs, including illicit drugs, prescription and over-the-counter medications, dietary supplements, inhalants and alcohol.  Includes total visits, gender, age group, race/ethnicity, outcome of visit, drug combinations, number of drugs involved in visit, drug frequency, and drugs confirmed by toxicology.Additional detail is provided for illicit drugs, psychotherapeutic drugs, central nervous system (CNS) drugs, respiratory drugs and cardiovascular drugs.

Tags: dawn-data, drug-related-ed-visits, emergency-department-data, miami-dade-county, samhsa
Organization: U.S. Department of Health & Human Services
National Survey of Substance Abuse Treatment Services: State Profiles 2014

The 2014 National Survey of Substance Abuse Treatment Services (N-SSATS) is an annual survey of facilities providing substance abuse treatment. The N-SSATS, conducted by the Substance Abuse and Mental Health Services Administration (SAMHSA), is designed to collect data on the location, characteristics, services offered, and number of clients in treatment at alcohol and drug abuse facilities (both public and private) throughout the 50 states, the District of Columbia, and other U.S. jurisdictions.

Tags: behavioral-health, n-ssats, samhsa, substance-abuse-treatment, treatment-facilities
Organization: U.S. Department of Health & Human Services
Short-term LDL cholesterol-lowering efficacy of plant stanol esters

Background
          The short-term cholesterol-lowering efficacy of plant stanol esters has been open to debate, and the data from different clinical studies with hypercholesterolemic subjects are variable, partly due to lack of systematic studies. Therefore, we investigated the time in days needed to obtain the full cholesterol-lowering effect of stanol esters in hypercholesterolemic subjects.
        
        
          Methods
          Eleven mildly to moderately hypercholesterolemic subjects consumed stanol ester margarine (2.0 g/day of stanols) as a part of their habitual diet for 14 days and the changes in serum lipid values were measured three times at 4, 8 and 15 days after the initiation of test margarine consumption (0 day). The returning of serum lipid concentrations to baseline was measured two times after 2 or 3 days and after 7 days of the end of the test margarine consumption.
        
        
          Results
          Serum LDL cholesterol concentrations were reduced from 0 day (4.51 ± 0.66 mmol/l) by 3.5% (P = ns), 9.9% (p < 0.05) and 10.2% (P < 0.05) at 4, 8 and 15 days, respectively. Serum campesterol/total cholesterol ratio, an indirect marker of intestinal cholesterol absorption, was significantly reduced on day 4 already. After ending the stanol ester use serum cholesterol concentrations began to return rapidly and after 7 days serum LDL cholesterol was 5.3% less than the initial value (P = ns).
        
        
          Conclusion
          The specific effect of plant stanol esters on serum LDL cholesterol can fully be obtained within 1–2 weeks of the use of plant stanol ester-enriched margarine.

Tags: hypercholesterolemia, ldl-cholesterol, lipid-levels, nih, plant-stanol-esters
Organization: U.S. Department of Health & Human Services
Association of MHC and rheumatoid arthritis:HLA polymorphisms in phenotypic variants of rheumatoid arthritis

Genes in the human leukocyte antigen (HLA) region remain the most powerful disease risk genes in rheumatoid arthritis (RA). Several allelic variants of HLA-DRB1 genes have been associated with RA, supporting a role for T-cell receptor-HLA-antigen interactions in the pathologic process. Disease-associated HLA-DRB1 alleles are similar but not identical and certain allelic variants are preferentially enriched in patient populations with defined clinical characteristics. Also, a gene dosing effect of HLA-DRB1 alleles has been suggested by the accumulation of patients with two RA-associated alleles, especially in patient subsets with a severe disease course. Therefore, polymorphisms in HLA genes are being explored as tools to dissect the clinical heterogeneity of the rheumatoid syndrome. Besides HLA polymorphisms, other risk genes will be helpful in defining genotypic profiles correlating with disease phenotypes. One such phenotype is the type of synovial lesion generated by the patient. HLA genes in conjunction with other genetic determinants may predispose patients to a certain pathway of synovial inflammation. Also, patients may or may not develop extraarticular manifestations, which are critical in determining morbidity and mortality. HLA genes, complemented by other RA risk genes, are likely involved in shaping the T-cell repertoire, including the emergence of an unusual T-cell population characterized by the potential of vascular injury, such as seen in extraarticular RA.

Tags: genetic-polymorphism, hla-drb1-alleles, nih, rheumatoid-arthritis, synovial-lesions
Organization: U.S. Department of Health & Human Services
2021 Uniform Reporting System (URS) Table For Tennessee

This is the 2021 Uniform Reporting System (URS) Output Tables for Tennessee. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: evidence-based-practices, mental-health-services, national-outcome-measures, samhsa, urs-data
Organization: U.S. Department of Health & Human Services
National Estimates of Drug-Related Emergency Department Visits, 2004-2011 - All Alcohol

Excel file with national estimates, rates, relative standard errors, trends and confidence intervals, covering 2004-2011 for emergency department visits involving alcohol.  For adults aged 21 and older, the alcohol was found in combination with other drugs. For patients under the age of 21, the visit may involve alcohol alone or in combination with other drugs.File includes data for over 500 drugs, including illicit drugs, prescription and over-the-counter medications, dietary supplements, inhalants and alcohol.  Includes total visits, gender, age group, race/ethnicity, outcome of visit, drug combinations, number of drugs involved in visit, drug frequency, and drugs confirmed by toxicology.Additional detail is provided for illicit drugs, psychotherapeutic drugs, central nervous system (CNS) drugs, respiratory drugs and cardiovascular drugs.

Tags: alcohol-related-ed, drug-related-visits, emergency-department-data, samhsa, substance-abuse-trends
Organization: U.S. Department of Health & Human Services
Emergency Department Visits for Drug Misuse or Abuse Involving the Pain Medication Tramadol

This Drug Abuse Warning Network (DAWN) short report shows the estimated number of emergency department visits involving misuse or abuse of the pain medication tramadol between 2005 and 2011.  The report specifically talks about age groups, gender, trends over time and other drugs such as narcotic pain relievers, anti-anxiety and insomnia medications.

Tags: drug-abuse, emergency-department, pain-medication, samhsa, tramadol-misuse
Organization: U.S. Department of Health & Human Services
2019 Methodological Summary and Definitions

Use this summary report to properly interpret 2019 NSDUH estimates of substance use and mental health issues. The report accompanies theannual detailed tablesand covers overall methodology, key definitions for measures and terms used in 2019 NSDUH reports and tables, and selected analyses of the measures and how they should be interpreted.The report is organized into five chapters:Introduction.Description of the survey, including information about the sample design, data collection procedures, and key aspects of data processing such as development of the analysis weights.Technical details on the statistical methods and measurement, such as suppression criteria for unreliable estimates, statistical testing procedures, issues around data accuracy, and measurement issues for selected substance use and mental health measures.Special topics related to prescription psychotherapeutic drugs.A comparison between NSDUH and other sources of data on substance use and mental health issues, including data sources for populations outside the NSDUH target population.An appendix covers key definitions used in NSDUH reports and tables.

Tags: data-definitions, mental-health, nsduh-methodology, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Korean women: breast cancer knowledge, attitudes and behaviors

Introduction
          Clustered within the nomenclature of Asian American are numerous subgroups, each with their own ethnic heritage, cultural, and linguistic characteristics. An understanding of the prevailing health knowledge, attitudes, and screening behaviors of these subgroups is essential for creating population-specific health promotion programs.
        
        
          Methods
          Korean American women (123) completed baseline surveys of breast cancer knowledge, attitudes, and screening behaviors as part of an Asian grocery store-based breast cancer education program evaluation. Follow-up telephone surveys, initiated two weeks later, were completed by 93 women.
        
        
          Results
          Low adherence to the American Cancer Society's breast cancer screening guidelines and insufficient breast cancer knowledge were reported. Participants' receptiveness to the grocery store-based breast cancer education program underscores the importance of finding ways to reach Korean women with breast cancer early detection information and repeated cues for screening. The data also suggest that the Asian grocery store-based cancer education program being tested may have been effective in motivating a proportion of the women to schedule a breast cancer screening between the baseline and follow-up surveys.
        
        
          Conclusion
          The program offers a viable strategy to reach Korean women that addresses the language, cultural, transportation, and time barriers they face in accessing breast cancer early detection information.

Tags: breast-cancer, cancer-screening, health-knowledge, korean-women, nih
Organization: U.S. Department of Health & Human Services
Compound 527374: 20,24-Dimethyl-hentriacontyl cyanide

Chemical compound data from PubChem database. IUPAC Name: 21,25-dimethyldotriacontanenitrile. Molecular Formula: C34H67N. Molecular Weight: 489.9. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Normalization and analysis of DNA microarray data by self-consistency and local regression

A robust semi-parametric normalization technique has been developed, based on the assumption that the large majority of genes will not have their relative expression levels changed from one treatment group to the next, and on the assumption that departures of the response from linearity are small and slowly varying. The method was tested using data simulated under various error models and it performs well.

Tags: dna-microarray, gene-expression, nih, normalization-method, statistical-analysis
Organization: U.S. Department of Health & Human Services
2020 Uniform Reporting System (URS) Table For Florida

This is the 2020 Uniform Reporting System (URS) Output Tables for Florida. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: florida-mental-health, mental-health-services, national-outcome-measures, samhsa, substance-abuse-treatment
Organization: U.S. Department of Health & Human Services
2016 Uniform Reporting System (URS) Table for Kentucky

This is the 2016 Uniform Reporting System (URS) Output Tables for Kentucky. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-data, kentucky, mental-health-services, noms-measures, samhsa
Organization: U.S. Department of Health & Human Services
NSDUH 2020 Questionnaire Dwelling Unit-Level And Person Pair-Level Sampling Weight Calibration

NSDUH allows for estimating characteristics at the person level, pair level, and household or QDU level. This report describes the weight calibration methods used for the pair- and QDU-level respondents. As described in the person-level report, NSDUH is an annual survey of about 67,500 people selected from the civilian, noninstitutionalized population aged 12 or older from all 50 states and the District of Columbia.

Tags: household-sampling, mental-health, samhsa, substance-use, survey-weights
Organization: U.S. Department of Health & Human Services
2013 CMHS Uniform Reporting System (URS) Tables for Louisiana

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Tables for Louisiana for 2013. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program.  State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, noms-measures, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services