AndreaBozzo/ceres-open-data-index huggingface dataset:
Alternative splicing regulates the physiological adaptation of the mouse hind limb postural and phasic muscles to microgravity

We sought to comprehensively elucidate the transcriptomic underpinnings of microgravity-induced muscle phenotypes in mice by evaluating both differential gene expression (DGE) and changes in alternative splicing (AS) due to extended spaceflight. Total RNA was isolated from the gastrocnemius and quadriceps, postural and phasic muscles of the hind limb, respectively, of 32-week-old female BALB/c mice exposed to microgravity or ground control conditions for nine weeks. RNA sequencing revealed that DGE and AS varied across postural and phasic muscle types with preferential employment of DGE in the gastrocnemius and AS in the quadriceps. Gene ontology analysis indicated that DGE and AS regulate distinct molecular processes. Various non-differentially expressed transcripts encoding musculoskeletal proteins (Tnnt3, Tnnt1, Neb, Ryr1, and Ttn) and muscle-specific RNA binding splicing regulators (Mbnl1 and Rbfox1) were found to have significant changes in AS that altered critical functional domains of their protein products. In striking contrast, microgravity-induced differentially expressed genes were associated with translation/ribosomal function and lipid metabolism. Our work serves as the first comprehensive investigation of coordinate changes in DGE and AS in large limb muscles across spaceflight. We propose that substantial remodeling of pre-mRNA by AS is a major component of transcriptomic adaptation of skeletal muscle to microgravity. The alternatively spliced genes identified here could be targeted by small molecule splicing regulator therapies to address microgravity-induced changes in muscle during spaceflight.

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Organization: National Aeronautics and Space Administration
Ultraviolet Imaging Telescope Master Catalog

The Ultraviolet Imaging Telescope (UIT) was one of three ultraviolet telescopes on the ASTRO-1 mission flown on the Space Shuttle Columbia during the period of 2 - 10 December 1990. The same three instruments were later flown on the Space Shuttle Endeavour during 3 - 17 March 1995, as part of the ASTRO-2 mission. Exposures were obtained on 70-mm photographic film in the 1200-3300 Angstrom range using broadband filters and later digitized using a Perkin-Elmer microdensitometer. The image resolution was 3 arcseconds over a 40 arcminute field of view and images of targets as faint as 21st (ultraviolet) magnitude were recorded. Overall, the UIT-1 mission obtained 821 exposures of 66 targets (361 near-UV and 460 far-UV), and UIT-2 obtained 758 images of 193 targets (all far-UV), for a total of 1579 exposures. This table contains only 1481 rows, 777 UIT-1 exposures (347 near-UV and 430 far-UV) and 704 UIT-2 exposures (all far-UV), implying that 98 exposures are &#39;missing&#39; from this table. This table was created by the HEASARC in April 2012 based on &lt;a href="https://cdsarc.cds.unistra.fr/ftp/cats/VI/104"&gt;CDS Catalog VI/104&lt;/a&gt; file uitlist.dat. This is a service provided by NASA HEASARC .

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Organization: National Aeronautics and Space Administration
eHOPS Aquila SED Data Catalog

The Extension of HOPS Out to 500 ParSecs (eHOPS) project used archival data to survey all the major star forming molecular clouds within 500 pc of the Sun, except Orion (which was surveyed by HOPS). The first eHOPS data release covers the Aquila molecular clouds (d ~ 436 pc). For every source detected in the Herschel/PACS bands, the eHOPS-Aquila catalog contains 1-850 micron SEDs assembled from 2MASS, Spitzer, Herschel, WISE, and JCMT/SCUBA-2 data. A total of 172 protostars are found in Aquila, tightly concentrated in the molecular filaments that thread the clouds. Of these, 72 (42%) are Class 0 protostars, 53 (31%) Class I protostars, 43 (25%) are flat-spectrum protostars, and 4 (2%) are Class II sources. Ten of the Class 0 protostars are young PACS Bright Red Sources similar to those discovered in Orion. eHOPS compares the SEDs to a grid of radiative transfer models to constrain the luminosities, envelope densities, and envelope masses of the protostars.

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Organization: National Aeronautics and Space Administration
Multi-modal transcriptional and chromatin accessibility analysis of brains from mice flown on the RR-3 mission

The Rodent Research-3 (RR-3) mission was sponsored by the pharmaceutical company Eli Lilly and Co. and the Center for the Advancement of Science in Space to study the effectiveness of a potential countermeasure for the loss of muscle and bone mass that occurs during spaceflight. Twenty BALB/c, 12-weeks old female mice (ten controls and ten treated) were flown to the ISS and housed in the Rodent Habitat for 39-42 days. Twenty mice of similar age, and matching sex and strain were used for ground controls housed in identical hardware and matching ISS environmental conditions. Basal controls were housed in standard vivarium cages. Spaceflight, ground controls and basal groups had blood collected, then were euthanized, had one hind limb removed, and finally whole carcasses were stored at -80 C until dissection. All mice in this data set received only the control/sham injection. Brain samples from three flight and three ground control animal groups were cut in half between hemispheres. One hemisphere of each brain was used for generating spatially resolved transcriptional profiling data. Hemispheres were cryosectioned so that 2 consecutive sections from the hippocampus of each brain was placed on Visium Gene Expression arrays. Samples were fixed, stained with Hematoxylin and Eosin and imaged. Imaging was followed by tissue permeabilization to release mRNA molecules from cells for capture onto the array surface. Subsequently, following the 10XGenomics Visium Gene Expression protocol, Spatial Transcriptomics RNA-seq libraries were prepared and sequenced. The other hemisphere of each brain was used for single nuclei RNA-seq and ATAC-seq using the 10X Multiome protocol. In addition, bulk RNA-seq (ribodepleted, target depth of 60 M clusters, PE 150 bp) was performed from a pool of RNA extracted from 10-20 sections from each of 3 flight and 3 ground control samples.

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Organization: National Aeronautics and Space Administration
GALILEO ORBITER A MAG RDR IDA HIGH RES V1.0

Galileo Orbiter Magnetometer (MAG) calibrated high-resolution data      from the Ida flyby in spacecraft, EME-50, RTN and Ida Solar      Ecliptic (IaSE) coordinates. These data cover the interval      1993-08-28 15:56 to 1993-08-28 17:50.

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Organization: National Aeronautics and Space Administration
Ginga LAC Log

The GINGALOG database table contains selected information from the Large Area Counter (LAC) aboard the third Japanese X-ray astronomy satellite Ginga. The Ginga experiment began on day 36, 5 February 1987 and ended in November 1991. Ginga consisted of the LAC, the all-sky monitor (ASM) and the gamma-ray burst detector (GBD). The satellite was in a circular orbit at 31 degree inclination with apogee 670 km and perigee 510 km, and with a period of 96 minutes. A Ginga observation consisted of varying numbers of major frames which had lengths of 4, 32, or 128 seconds, depending on the setting of the bitrate. Each GINGALOG database entry is the first record of a series of observations having the same values of &quot;ACS MONITOR&quot; (Attitude Control System). When this value changes, a new FITS file was written. The other Ginga catalog database, GINGAMODE is also a subset of the same LAC dump file used to create GINGALOG. GINGAMODE contains a listing whenever any of the following changes: &quot;BITRATE&quot;, &quot;LACMODE&quot;, &quot;DISCRIMINATOR&quot;, or &quot;ACS MONITOR&quot;. Thus, GINGAMODE monitors changes in several parameters and GINGALOG is a basic log of all the FITS files. Both databases point to the corresponding archived Flexible Image Transport System (FITS) files, but GINGAMODE may have more than one entry for a given FILE_LCURVE in the database. The user is invited to browse though the observations available from Ginga using GINGALOG or GINGAMODE, then extract the FITS files for more detailed analysis. The Ginga LAC Log Catalog was prepared from data sent to NASA/GSFC from the Institute of Space and Astronautical Science (ISAS) in Japan. This is a service provided by NASA HEASARC .

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Organization: National Aeronautics and Space Administration
Magellanic Clouds High-Mass X-Ray Binaries Catalog

This database table contains a catalog of high-mass X-ray binaries (HMXBs) in the Small and Large Magellanic Clouds (SMC and LMC). The catalog lists source name(s), coordinates, apparent magnitudes, orbital parameters, and X-ray luminosities for 128 HMXBs, together with the stellar parameters of the components, other characteristic properties and a comprehensive selection of the relevant literature. The aim of this catalog is to provide easy access to the basic information on the X-ray sources and their counterparts in other wavelength ranges (UV, optical, IR, radio). Most of the sources have been identified as Be/X-ray binaries. Some sources, however, are only tentatively identified as HMXBs on the basis of a transient character and/or a hard X-ray spectrum. Further identification in other wavelength bands is needed to finally determine the nature of these sources. In cases where there is some doubt about the high-mass nature of the X-ray binary this is mentioned. Literature published before 1 May 2005 has, as far as possible, been taken into account. Information on the numbers used to code references is available at &lt;a href="https://cdsarc.cds.unistra.fr/ftp/cats/J/A+A/442/1135/refs.dat"&gt;CDS&lt;/a&gt;. Individual notes on each HMXB are also available for &lt;a href="https://cdsarc.cds.unistra.fr/ftp/cats/J/A+A/442/1135/notes1.dat"&gt;SMC systems&lt;/a&gt; and for &lt;a href="https://cdsarc.cds.unistra.fr/ftp/cats/J/A+A/442/1135/notes2.dat"&gt;LMC systems&lt;/a&gt; at the same site. This Browse table contains the combination of 92 HMXBs in the SMC and 36 HMXBs in the LMC which were listed in Tables 1 and 2, respectively, of the published version of this catalog. The HEASARC has added a parameter called cloud_id which can be used to identify which Magellanic Cloud any specified HMXB belongs to (the SMC or the LMC). This database was created by the HEASARC in December 2005 based on &lt;a href="https://cdsarc.cds.unistra.fr/ftp/cats/J/A+A/442/1135"&gt;CDS Catalog J/A+A/442/1135&lt;/a&gt;, table1.dat and table2.dat. This is a service provided by NASA HEASARC .

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Organization: National Aeronautics and Space Administration
MESSENGER E/V/H MASCS 5 VIRS DERIVED ANALYSIS DATA V2.0

Abstract : This data set consists of the MESSENGER MASCS VIRS derived analysis product, also known as the DAP. The DAP is a 500 meter per pixel mosaic map of 1 wavelength (750 nm) of VIRS spectral data for footprints covering the planet Mercury. Data products are derived from science data collected by the VIRS detector during orbital operations of Mercury. This is version 2 of this data set.

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Organization: National Aeronautics and Space Administration
VLA Lockman Hole 3-GHz Radio Source Catalog

This table is from the second of two papers describing the observations and source catalogs derived from sensitive 3-GHz images of the Lockman Hole North using the Karl G. Jansky Very Large Array (VLA). In their paper, the authors describe the reduction and cataloguing process, which yielded an image with 8-arcsecond resolution and instrumental noise of sigma&lt;sub&gt;n&lt;/sub&gt; = 1.01 &micro;Jy/beam (&micro;Jy/beam) rms (before primary beam corrections) and a catalog of 558 sources detected above 5 * sigma&lt;sub&gt;n&lt;/sub&gt;. The authors also include details of how they estimate source spectral indices across the 2-GHz VLA bandwidth, finding a median index of -0.76 +/- 0.04. Stacking of source spectra reveals a flattening of spectral index with decreasing flux density. In the reference paper, the authors present a source count derived from the catalog. They show a traditional count estimate compared with a completely independent estimate made via a P(D) confusion analysis, and find very good agreement. Cross-matches of the catalog with X-ray, optical, infrared, radio, and redshift catalogs are also presented. The X-ray, optical and infrared data, as well as AGN selection criteria allow them to classify 10% as radio-loud AGN, 28% as radio-quiet AGN, and 58% as star-forming galaxies, with only 4% unclassified. Observations were made with the VLA in the C configuration at S band, with a frequency range of 2 to 4GHz, with a total of roughly 50 hours of on-source time in 2012. The HEASARC has converted the radio and IR flux density units from those given in the original table (&micro;Jy and &micro;Jy/beam) to its standard units for radio flux densities (mJy and mJy/beam). This table was created by the HEASARC in April 2017 based on &lt;a href="https://cdsarc.cds.unistra.fr/ftp/cats/J/MNRAS/462/2934"&gt;CDS Catalog J/MNRAS/462/2934&lt;/a&gt; files cat3ghz.dat and catcrx.dat. This is a service provided by NASA HEASARC .

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Organization: National Aeronautics and Space Administration
MARS EXPRESS MARS MRS 1/2/3 EXTENDED MISSION 8 4194 V1.0

This is a Mars Express Radio Science data set, collected during the extended mission phase 2021-01-01 to 2022-12-31. It is a Occultation measurement and covers the time 2021-03-08T08:18:57.100 to 2021-03-08T08:41:05.449.

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Organization: National Aeronautics and Space Administration
ABI G17 Deep Blue L3 Daily Aerosol Data, 1 x 1 degree grid

The ABI G17 Deep Blue L3 Daily Aerosol Data, 1 x 1 degree grid product, short-name AERDB_D3_ABI_G17, derived from the L2 (AERDB_L2_ABI_G17) input data, each D3 ABI/GOES-17 product is produced daily at 1 x 1-degree horizontal resolution. In general, in this daily L3 (identified in the short-name as D3) aggregated product, each data field represents the arithmetic mean of all cells whose latitude and longitude places them within the bounds of each grid element. Another statistic like standard deviation is also provided in some cases. The final retrievals used in the aggregation process are Quality Assurance (QA)-filtered best-estimate values for cells that are measured on the day of interest. Further, at least three such retrievals are required to render the validity of a grid cell on any given day. This first release of these products spans from May 2019 through April 2020 with a potential to generate additional temporal coverage in the future. The Level-3 (L3) Advanced Baseline Imager (ABI) Geostationary Operational Environmental Satellite-17 (GOES-17) Deep Blue Daily Aerosol dataset is part of a 12-product suite produced by an Earth Science Research from Operational Geostationary Satellite Systems (ESROGSS)-funded project. The 12 products in this project include nine derived from three Geostationary Earth Observation (GEO) instruments and three from merged data from GEO and Low-Earth Orbit (LEO) instruments. The AERDB_D3_ABI_G17 product, in netCDF4 format, contains 48 Science Data Set (SDS) layers. For more information consult LAADS product description page at: https://ladsweb.modaps.eosdis.nasa.gov/missions-and-measurements/products/AERDB_D3_ABI_G17 Or, Deep Blue aerosol project webpage at: https://earth.gsfc.nasa.gov/climate/data/deep-blue

Tags: earth-science-aerosols-atmosphere, earth-science-aerosols-atmosphere-aerosol-optical-depth-thickness, earth-science-aerosols-atmosphere-aerosol-optical-depth-thickness-angstrom-exponent, earth-science-aerosols-atmosphere-aerosol-particle-properties
Organization: National Aeronautics and Space Administration
H Persei Chandra X-Ray Point Source Catalog

This table contains some of the results from a Chandra/ACIS-I observations of the massive ~ 13-14 Myr-old cluster, h Persei, part of the famous Double Cluster (h and Chi Persei) in Perseus. Combining the list of 330 Chandra-detected sources with new optical/IR photometry and optical spectroscopy reveals ~ 165 X-ray bright stars with V &lt;~ 23. Roughly 142 have optical magnitudes and colors consistent with cluster membership. The observed distribution of X-ray luminosity L&lt;sub&gt;x&lt;/sub&gt; peaks at L&lt;sub&gt;x&lt;/sub&gt; ~ 10&lt;sup&gt;30.3&lt;/sup&gt; erg s&lt;sup&gt;-1&lt;/sup&gt; and likely traces the bright edge of a far larger population of ~ 0.4-2 M&lt;sub&gt;sun&lt;/sub&gt; X-ray active stars. From a short list of X-ray active stars with IRAC 8-micron excess from warm, terrestrial zone dust, the authors derive a maximum X-ray flux incident on forming terrestrial planets. Although there is no correlation between X-ray activity and IRAC excess, the fractional X-ray luminosity correlates with optical colors and spectral type. By comparing the distribution of L&lt;sub&gt;x&lt;/sub&gt;/L&lt;sub&gt;star&lt;/sub&gt; versus spectral type and (V-I) in h Per with results for other 1-100 Myr-old clusters, the authors show that stars slightly more massive than the Sun (&gt;~ 1.5 M&lt;sub&gt;sun&lt;/sub&gt;) fall out of X-ray saturation by ~ 10-15 Myr. Changes in stellar structure for &gt;~ 1.5 M&lt;sub&gt;sun&lt;/sub&gt; stars likely play an important role in this decline of X-ray emission. Chandra observations of h Persei were taken with a 41.1 ks exposure on 2004 December 2, (Obs. ID 5407; Sequence Number 200341) with the ACIS detector (chips 0, 1, 2, 3, 6, and 7). The data were obtained in dithered, timed mode, with a frametime of 3.2 s. On-board event rejection and event telemetry was in the VFAINT mode. The field was centered on RA(2000) = 2h19m00s, Dec(2000) = 57d07&#39;12&quot;, close to the center of h Persei from Bragg &amp; Kenyon (2005, AJ, 130, 134) (RA(2000) = 2h18m56.4s, Dec(2000) = 57d08&#39;25&quot;) and observed at a roll angle of 229 degrees. The data were not registered to an astrometric reference frame (e.g., Two Micron All Sky Survey, 2MASS). The ACIS-I field covers a 17&#39; x 17&#39; area. This table was created by the HEASARC in March 2009 based on the electronic versions of Tables 1 and 2 from the paper which were obtained from the Astronomical Journal web site. This is a service provided by NASA HEASARC .

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Organization: National Aeronautics and Space Administration
VO2 MARS RADIO SCIENCE SUBSYSTEM RESAMPLED LOS GRAVITY V1.0

Line of sight (LOS) gravity data were obtained as part of the Radio Science Experiment by tracking 79 orbits of the Viking Orbiter 2. The data set consists of a table with the following columns: spacecraft latitude, longitude (degrees), accelerations, and altitude (km). The acceleration data were determined from differentiation of raw Doppler residuals and are expressed as units of mm/s**2. To obtain LOS gravity in milligals, accelerations need to be multiplied by 100. An acceleration of 1.20 mm/s**2, therefore, corresponds to 120 mgal, a large gravity anomaly.

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Organization: National Aeronautics and Space Administration
Gene-metabolite networks associated with impediment of bone fracture repair in spaceflight

Adverse effects of spaceflight on musculoskeletal health increase the risk of bone injury and impairment of fracture healing. Its yet elusive molecular comprehension warrants immediate attention, since space travel is becoming more frequent. Here we examined the effects of spaceflight on bone fracture healing using a 2 mm femoral segmental bone defect (SBD) model. Forty, 9-week-old, male C57BL/6J mice were randomized into 4 groups: 1) Sham surgery on Ground (G-Sham); 2) Sham surgery housed in Spaceflight (FLT-Sham); 3) SBD surgery on Ground (G-Surgery); and 4) SBD surgery housed in Spaceflight (FLT-Surgery). Surgery procedures occurred 4 days prior to launch; post-launch, the spaceflight mice were house in the rodent habitats on the International Space Station (ISS) for approximately 4 weeks before euthanasia. Mice remaining on the Earth were subjected to identical housing and experimental conditions. The right femur from half of the spaceflight and ground groups was investigated by micro-computed tomography (µCT). In the remaining mice, the callus regions from surgery groups and corresponding femoral segments in sham mice were probed by global transcriptomic and metabolomic assays. µCT confirmed escalated bone loss in FLT-Sham compared to G-Sham mice. Comparing to their respective on-ground counterparts, the morbidity gene-network signal was inhibited in sham spaceflight mice but activated in the spaceflight callus. µCT analyses of spaceflight callus revealed increased trabecular spacing and decreased trabecular connectivity. Activated apoptotic signals in spaceflight callus were synchronized with inhibited cell migration signals that potentially hindered the wound site to recruit growth factors. A major pro-apoptotic and anti-migration gene network, namely the RANK-NFκB axis, emerged as the central node in spaceflight callus. Concluding, spaceflight suppressed a unique biomolecular mechanism in callus tissue to facilitate a failed regeneration, which merits a customized intervention strategy. Source name abbreviation key: surgically operated on using the sham saline treatment (Sh);  non-surgical control (NS); Ground Control group (G); Flight Group (F); Whole Body frozen as sample on ISS (W).

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Organization: National Aeronautics and Space Administration
Relevance of Unfolded Protein Response to Spaceflight-Induced Transcriptional Reprogramming in Arabidopsis

Plants are primary producers of food and oxygen on Earth and will likewise be indispensable to the establishment of large-scale sustainable ecosystems and human survival in space. To contribute to the understanding of how plants respond to spaceflight stresses, we examined the relevance of the unfolded protein response (UPR), a conserved signaling cascade that responds to a number of unfavorable environmental stresses, in the model plant species Arabidopsis thaliana. To do so, we compared the transcriptional responses of wild type and UPR-defective seedlings to spaceflight during the SpaceX-CRS12 mission to the International Space Station. We established that orbital culture substantially altered the expression of hundreds of stress related genes compared to ground control conditions. Although many of these genes were differentially regulated in the UPR mutants in the ground control conditions compared to wild type, their expression was largely equalized in all genotypes by flight. Our results have yielded new information on how plants respond to growth in orbit and support the hypothesis that spaceflight induces the activation of signaling pathways that compensate for the loss of UPR regulators in the control of downstream transcriptional regulatory networks.

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Organization: National Aeronautics and Space Administration