AndreaBozzo/ceres-open-data-index huggingface dataset:
Morphological types of breast cancer in family members and multiple primary tumours: is morphology genetically determined?

Background
          We conducted the present study to determine whether breast cancer morphology is genetically determined.
        
        
          Methods
          Using the nationwide Swedish Family Cancer Database, which includes data on 10.2 million individuals and over 25,000 morphology-specific breast cancers, we followed morphological types in familial cancers between mothers and daughters and between sisters. Additionally, we recorded morphological data in women who presented with two primary breast cancers and in those who presented with an invasive and in situ breast cancer. We used kappa statistics to examine the association between genetics and morphology. A kappa value of 0 indicates that the process is random and a value of 1 indicates that it is completely determined (i.e. genetic); values between 0.40 and 0.60 are considered to indicate a moderately determined process.
        
        
          Results
          The study sample included a total of 25,730 first and 3394 second invasive breast cancers, and 2990 in situ breast cancers. Ductal, lobular, tubuloductal and comedo were the most common invasive types. We identified 164 mother-daughter pairs with breast cancer of a defined morphology, yielding a low kappa value of 0.08. Among 100 sister pairs the kappa value was 0.002. In individuals with two primary breast cancers the kappa values were 0.22 and 0.01 for two invasive and in situ-invasive pairs, respectively. However, for a tumour with a subsequent tumour detected in the contralateral breast less than 1 year later the kappa value was 0.47.
        
        
          Conclusion
          The data suggest that breast cancer morphology is not genetically determined. However, because of mixed morphologies and the overwhelming prevalence of ductal morphology, the results for rare morphologies should be interpreted with caution.

Tags: breast-cancer-morphology, cancer-genetics, familial-breast-cancer, nih, tumor-morphology
Organization: U.S. Department of Health & Human Services
Table 6. Illicit Drug Use Other Than Marijuana in the Past Month, by Age Group and State: Percentages, Annual Averages Based on 2010 and 2011 NSDUHs

This report presents State estimates for measures of past month illicit drug use other than marijuana based on the combined 2010 and 2011 National Surveys on Drug Use and Health (NSDUHs). Resuts are provided by age group.

Tags: drug-prevalence, illicit-drug-use, nsduh, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
2018 Uniform Reporting System (URS) Table for Indiana

This is the 2018 Uniform Reporting System (URS) Output Tables for Indiana. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: indiana-mental-health, mental-health-services, national-outcome-measures, samhsa, substance-abuse-treatment
Organization: U.S. Department of Health & Human Services
The DAWN Report: Emergency Department Visits for Adverse Reactions Involving the Insomnia Medication Zolpidem

This Drug Abuse Warning Network (DAWN) short report looks at the estimated number of emergency room visits for adverse reactions involving involving the prescription sleep qie zolpidem for 2005 through 2010. The report focuses on gender, age groups and other pharmaceuticals such as pain relievers, other anti-anxiety and insomnia medications or alcohol taken with zolpidem.

Tags: drug-abuse-warning-network, emergency-department-visits, insomnia-medication, samhsa, zolpidem-adverse-events
Organization: U.S. Department of Health & Human Services
Compound 525361: 2,3-Dimethyl-4,5-dithiaheptane

Chemical compound data from PubChem database. IUPAC Name: 2-(ethyldisulfanyl)-3-methylbutane. Molecular Formula: C7H16S2. Molecular Weight: 164.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Treatment Episode Data Set (TEDS): 2014, National Discharges From Substance Abuse Treatment Services

This report presents data from the Treatment Episode Data Set (TEDS) for discharges from treatment in 2014. It is a companion to the reports Treatment Episode Data Set (TEDS): 2004-2014 National Admissions to Substance Abuse Treatment and Treatment Episode Data Set (TEDS): 2004-2014 State Admissions to Substance Abuse Treatment. These reports provide information on the demographic and substance abuse characteristics of substance abuse treatment admissions and discharges aged 12 and older in facilities that report to individual state administrative data systems. In addition, characteristics used to analyze changes from admission to discharge among the linked admission and discharge records are included. Primary substance of abuse, frequency of use, and employment status at admission are repeated in several tables. This is done so that characteristics at admission and discharge can be appropriately compared with each other and to ensure the inclusion of important data that might otherwise be overlooked.

Tags: addiction-recovery, samhsa, substance-abuse-treatment, teds-data, treatment-discharge-data
Organization: U.S. Department of Health & Human Services
2010 State Profile — Nevada

This state profile includes data from facilities in Nevada that reported to N-SSATS for the survey reference date March 31, 2010. Data were collected on the location, characteristics, services offered, and number of clients in treatment at alcohol and drug abuse treatment facilities (both public and private) in Nevada. In Nevada, 84 substance abuse treatment facilities were included in the 2010 N-SSATS, reporting that there were 7,041 clients in substance abuse treatment on March 31, 2010. The survey response rate in Nevada was 95.6%.

Tags: addiction-services, n-ssats, nevada, samhsa, substance-abuse-treatment
Organization: U.S. Department of Health & Human Services
Increased production of pro-inflammatory cytokines and enhanced T cell responses after activation of human dendritic cells with IL-1 and CD40 ligand

Background
          Various microbial, inflammatory and immune signals regulate the activation of dendritic cells (DC), determining their ability to interact with naïve T cells and to produce cytokines that direct T cell development. In particular, CD40L and IL-1 cooperatively activate DC to secrete high levels of IL-12. The immuno-stimulatory capacity of such DC is otherwise not well-defined prompting further characterization of the effects of IL-1 and family members on DC activation in comparison with other pro-inflammatory stimuli.
        
        
          Results
          Human DC co-activated in vitro by CD40L and IL-1β expressed numerous cytokine genes including IL-12β, IL-23 p19, IL-1β, IL-1α, IL-1Ra, IL-10, IL-6, IL-18 and IFN-γ. These DC produced high levels of IL-12 protein and appeared capable of producing IFN-γ. Potent CD4+ and CD8+ T cell-stimulatory properties were acquired by DC under conditions that also induced IL-12. Notably, these DC induced rapid differentiation of fluMP-specific CD8+ T cells. Molecules related to IL-1β, like IL-1α, co-induced IL-12 secretion whereas IL-18 did not. Conversely, the inhibitor IL-1Ra, produced endogenously by DC curtailed IL-12 production in response to CD40L.
        
        
          Conclusions
          IL-1 and IL-1Ra play a biologically-relevant role in the positive and negative regulation of DC activation. In conjunction with CD40L, IL-1 sends a powerful activation signal to DC that could be distinguished from other modes of activation. This signal enables the production of pro-inflammatory cytokines by DC, and enhances the differentiation of naïve T cells into effectors of type-1 cellular immune responses.

Tags: dendritic-cells, il-12-production, nih, pro-inflammatory-cytokines, t-cell-activation
Organization: U.S. Department of Health & Human Services
NCANDS Child File Codebook

The Child File data submission contains case-level data. States submit case-level data by constructing an electronic file of child-specific records for each report of alleged child abuse and neglect that received a CPS response. Only completed reports that resulted in a disposition (finding) during the reporting year are submitted in each state’s data file. The Child File is supplemented by agency-level aggregate statistics in a separate data submission called the Agency File. States are asked to submit both the Child File and the Agency File each year. This codebook shows the data elements included in a Child File submission, along with definitions, values, and technical guidance provided to states.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: abuse, assessment, neglect, policy, reporting
Organization: U.S. Department of Health & Human Services
2021 Uniform Reporting System (URS) Table For Maine

This is the 2021 Uniform Reporting System (URS) Output Tables for Maine. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-program, mental-health-services, national-outcome-measures, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
19th NCCAN Day Two Plenary

The 19th National Conference on Child Abuse and Neglect (NCCAN) was held from April 30 to May 2, 2014, in New Orleans, LA. Each day featured a plenary session on a specific topic. The day two plenary featured the presentation, "Why, When We Know So Much, Do We Do So Little? Overcoming Early Childhood Adversity," by Howard Spivak, M.D.; Nadine Burke Harris, M.D., M.P.H., F.A.A.P.; and Larry Adelman. Additionally, Parents Anonymous® and the National Alliance of Children's Trust and Prevention Funds presented awards.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: abuse, child, neglect, policy, prevention
Organization: U.S. Department of Health & Human Services
Federal Inter-Agency Work Group on Child Abuse & Neglect

The amendments to the Child Abuse Prevention and Treatment Act (CAPTA) of 1988 created a Federal Inter-Agency Task Force on Child Abuse and Neglect. The Task Force consisted of approximately 30 member agencies drawn from the eight Cabinet Departments and the Office of Personnel Management. The Director of the National Center on Child Abuse and Neglect (NCCAN) was the statutory chairperson of the Task Force.

When the 1996 CAPTA amendments created an Office on Child Abuse and Neglect, replacing the National Center on Child Abuse and Neglect (NCCAN), it also eliminated the requirement for a Task Force on Child Abuse and Neglect.

However, the existing Task Force members agreed that it was important to maintain the connections and to continue their work. The name was changed to the Federal Interagency Work Group on Child Abuse and Neglect as Task Forces have specific meanings and requirements under Federal law.

Since 1996, the Office on Child Abuse and Neglect has continued to lead and coordinate the Federal Interagency Workgroup on Child Abuse and Neglect (FEDIAWG). The FEDIAWG meets on a quarterly basis and includes representation from over 35 Federal agencies. The overall goals of the FEDIAWG are:

The following Departments and their subsequent Program Offices are members of the FEDIAWG:

For more information on the FEDIAWG and upcoming meetings, contact Lauren Fischman.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: abuse, child, neglect, policy, prevention
Organization: U.S. Department of Health & Human Services
Compound 525597: N,N-Dimethyl-N'-(4-ethoxyphenyl)-p-methylbenzamidine

Chemical compound data from PubChem database. IUPAC Name: N'-(4-ethoxyphenyl)-N,N,4-trimethylbenzenecarboximidamide. Molecular Formula: C18H22N2O. Molecular Weight: 282.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: United States, Volume 5

The Behavioral Health Barometer: United States, Volume 5: Indicators as measured through the 2017 National Survey on Drug Use and Health and the National Survey of Substance Abuse Treatment Services, is one of a series of national, regional, and state reports that provide a snapshot of substance use and mental health in the United States.

Tags: behavioral-health, mental-health, nsduh-data, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Funding source, trial outcome and reporting quality: are they related? Results of a pilot study

Background
          There has been increasing concern regarding the potential effects of the commercialization of research.
        
        
          Methods
          In order to examine the relationships between funding source, trial outcome and reporting quality, recent issues of five peer-reviewed, high impact factor, general medical journals were hand-searched to identify a sample of 100 randomized controlled trials (20 trials/journal). Relevant data, including funding source (industry/not-for-profit/mixed/not reported) and statistical significance of primary outcome (favouring new treatment/favouring conventional treatment/neutral/unclear), were abstracted. Quality scores were assigned using the Jadad scale and the adequacy of allocation concealment.
        
        
          Results
          Sixty-six percent of trials received some industry funding. Trial outcome was not associated with funding source (p= .461). There was a preponderance of favourable statistical conclusions among published trials with 67% reporting results that favored a new treatment whereas 6% favoured the conventional treatment. Quality scores were not associated with funding source or trial outcome.
        
        
          Conclusions
          It is not known whether the absence of significant associations between funding source, trial outcome and reporting quality reflects a true absence of an association or is an artefact of inadequate statistical power, reliance on voluntary disclosure of funding information, a focus on trials recently published in the top medical journals, or some combination thereof. Continued and expanded monitoring of potential conflicts is recommended, particularly in light of new guidelines for disclosure that have been endorsed by the ICMJE.

Tags: funding-source, nih, randomized-controlled-trials, reporting-quality, trial-outcome
Organization: U.S. Department of Health & Human Services
2014-2016 NSDUH Substate Region Estimates – Excel Tables and CSV Files

Prevalence estimates for 15 measures of substance use and mental illness are provided along with 95% confidence intervals for persons aged 12 or older for the substance use measures, persons aged 18 or older for the mental illness measures, and persons aged 12-20 for one alcohol measure.

Tags: mental-illness, nsduh-data, prevalence-estimates, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Compound 528382: 2,6-Dichloro-4-hydroxybenzaldehyde

Chemical compound data from PubChem database. IUPAC Name: 2,6-dichloro-4-hydroxybenzaldehyde. Molecular Formula: C7H4Cl2O2. Molecular Weight: 191.01. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 527314: Methyl 2-[4-methoxy-3-(trifluoromethyl)anilino]benzoate

Chemical compound data from PubChem database. IUPAC Name: methyl 2-[4-methoxy-3-(trifluoromethyl)anilino]benzoate. Molecular Formula: C16H14F3NO3. Molecular Weight: 325.28. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Colorado: 2011-2012 NSDUH

This report presents Colorado\'s estimates for 25 measures of substance use and mental health based on the combined 2011 and 2012 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided by State and for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: colorado-nsduh, mental-health, samhsa, serious-mental-illness, substance-use
Organization: U.S. Department of Health & Human Services
National Survey of Substance Abuse Treatment Services: State Profiles 2007

The 2007 National Survey of Substance Abuse Treatment Services (N-SSATS) is an annual survey of facilities providing substance abuse treatment. The N-SSATS, conducted by the Substance Abuse and Mental Health Services Administration (SAMHSA), is designed to collect data on the location, characteristics, services offered, and number of clients in treatment at alcohol and drug abuse facilities (both public and private) throughout the 50 states, the District of Columbia, and other U.S. jurisdictions.

Tags: addiction-services, n-ssats, samhsa, substance-abuse-treatment, treatment-facilities
Organization: U.S. Department of Health & Human Services
Compound 525200: Chloromethyl 3-chlorohexanoate

Chemical compound data from PubChem database. IUPAC Name: chloromethyl 3-chlorohexanoate. Molecular Formula: C7H12Cl2O2. Molecular Weight: 199.07. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2011 CMHS Uniform Reporting System (URS) Tables for Delaware

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2011. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, delaware, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
The current status of primary prevention in coronary heart disease

During the second part of the twentieth century, research advances caused a substantial decline in the rate of coronary heart disease. The decline lasted from the mid-1960s until the early 1990s and occurred primarily in Western countries. However, an unfavourable trend in coronary heart disease related mortality has gradually developed during the 1990s, with cardiovascular diseases anticipated to remain the main cause of overall mortality for the foreseeable future. The present paper aims at analyzing the current status of the main determinants of population-wide coronary heart disease prevention.

Tags: cardiovascular-mortality, coronary-heart-disease, nih, primary-prevention, risk-factors
Organization: U.S. Department of Health & Human Services
Compound 525683: N-(4-Chlorobenzylidene)-p-toluidine

Chemical compound data from PubChem database. IUPAC Name: 1-(4-chlorophenyl)-N-(4-methylphenyl)methanimine. Molecular Formula: C14H12ClN. Molecular Weight: 229.7. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
The NSDUH Report: Suicidal Thoughts and Behavior in 33 Metropolitan Statistical Areas: 2008 to 2010

This short report uses 2008 to 2010 National Survey on Drug Use and Health (NSDUH) to assess past year serious thoughts of suicide, suicide plans, or suicide attempts among adults aged 18 or older living in 33 metropolitan statistical areas.

Tags: adult-suicide, mental-health, samhsa, suicidal-ideation, suicide-attempts
Organization: U.S. Department of Health & Human Services
2019 Uniform Reporting System (URS) Table for Kentucky

These are the 2019 Uniform Reporting System (URS) Output Tables for Kentucky. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, kentucky, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Table 6. Illicit Drug Use Other than Marijuana in the Past Month among Persons Aged 12 or Older, by State and Substate Regions: Percentages, Annual Averages Based on 2010, 2011, and 2012 NSDUHs

Table 6. Illicit Drug Use Other than Marijuana in the Past Month among Persons Aged 12 or Older, by State and Substate Regions: Percentages, Annual Averages Based on 2010, 2011, and 2012 NSDUHs

Tags: adolescent-health, illicit-drug-use, nsduh-data, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Does Council Tax Valuation Band (CTVB) correlate with Under-Privileged Area 8 (UPA8) score and could it be a better 'Jarman Index'?

Background
          Widespread scepticism persists on the use of the Under-Privileged Area (UPA8) score of Jarman in distributing supplementary resources to so-attributed 'deprived' UK general practices. The search for better 'needs' markers continues. Having already shown that Council Tax Valuation Band (CTVB) is a predictor of UK GP workload, we compare, here, CTVB of residence of a random sample of patients with their respective 'Jarman' scores.
        
        
          Methods
          Correlation coefficient is calculated between (i) the CTVB of residence of a randomised sample of patients from an English general practice and (ii) the UPA8 scores of the relevant enumeration districts in which they live.
        
        
          Results
          There is a highly significant correlation between the two measures despite modest study size of 478 patients (85% response).
        
        
          Conclusions
          The proposal that CTVB is a marker of deprivation and of clinical demand should be examined in more detail: it correlates with 'Jarman', which is already used in NHS resource allocation. But unlike 'Jarman', CTVB is simple, objective, and free of the problems of Census data. CTVB, being household-based, can be aggregated at will.

Tags: council-tax, deprivation-index, jarman-index, nih, upa8-score
Organization: U.S. Department of Health & Human Services