AndreaBozzo/ceres-open-data-index huggingface dataset:
Safety Assessment Family Evaluation—Family Connections (SAFE-FC) Program Manual

This PII grantee program manual provides detailed information about the implementation process of the Washoe County Department of Social Services (WCDSSS) Safety Assessment Family Evaluation—Family Connections (SAFE-FC) program. Its purpose is to assist others in the field in replicating or adapting SAFE-FC for their local use. Readers will find background information, lessons learned, and other practical information based on the experience of the WCDSS team. The manual can be especially helpful if you are considering implementation of the intervention, interested in addressing the needs of similar target populations, or interested in lessons learned from real-world implementation experiences. Together, the PII program manuals help to build a base of replicable interventions that can serve the complex needs of diverse communities of children and families.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: grant, guidance, manual, policy, work
Organization: U.S. Department of Health & Human Services
Do multiple outcome measures require p-value adjustment?

Background
          Readers may question the interpretation of findings in clinical trials when multiple outcome measures are used without adjustment of the p-value. This question arises because of the increased risk of Type I errors (findings of false "significance") when multiple simultaneous hypotheses are tested at set p-values. The primary aim of this study was to estimate the need to make appropriate p-value adjustments in clinical trials to compensate for a possible increased risk in committing Type I errors when multiple outcome measures are used.
        
        
          Discussion
          The classicists believe that the chance of finding at least one test statistically significant due to chance and incorrectly declaring a difference increases as the number of comparisons increases. The rationalists have the following objections to that theory: 1) P-value adjustments are calculated based on how many tests are to be considered, and that number has been defined arbitrarily and variably; 2) P-value adjustments reduce the chance of making type I errors, but they increase the chance of making type II errors or needing to increase the sample size.
        
        
          Summary
          Readers should balance a study's statistical significance with the magnitude of effect, the quality of the study and with findings from other studies. Researchers facing multiple outcome measures might want to either select a primary outcome measure or use a global assessment measure, rather than adjusting the p-value.

Tags: clinical-trials, nih, outcome-measures, p-value-adjustment, type-i-error
Organization: U.S. Department of Health & Human Services
Compound 529753: 17alpha-Ethinylestrdiol, di-trimethylsilyl

Chemical compound data from PubChem database. IUPAC Name: (17-ethynyl-13-methyl-3-trimethylsilyloxy-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl)oxy-trimethylsilane. Molecular Formula: C26H40O2Si2. Molecular Weight: 440.8. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 529329: Oxetane, 3-methyl-3-(4-methylphenyloxy)methyl

Chemical compound data from PubChem database. IUPAC Name: 3-methyl-3-[(4-methylphenoxy)methyl]oxetane. Molecular Formula: C12H16O2. Molecular Weight: 192.25. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Concordance between genetic relatedness and phenotypic similarities of

Background
          Despite the medical importance of trichomoniasis, little is known about the genetic relatedness of Trichomonas vaginalis strains with similar biological characteristics. Furthermore, the distribution of endobionts such as mycoplasmas or Trichomonas vaginalis virus (TVV) in the T. vaginalis metapopulation is poorly characterised.
        
        
          Results
          We assayed the relationship between 20 strains of T. vaginalis from 8 countries using the Random Amplified Polymorphic DNA (RAPD) analysis with 27 random primers. The genealogical tree was constructed and its bootstrap values were computed using the program FreeTree. Using the permutation tail probability tests we found that the topology of the tree reflected both the pattern of resistance to metronidazole (the major anti-trichomonal drug) (p < 0.01) and the pattern of infection of strains by mycoplasmas (p < 0.05). However, the tree did not reflect pattern of virulence, geographic origin or infection by TVV. Despite low bootstrap support for many branches, the significant clustering of strains with similar drug susceptibility suggests that the tree approaches the true genealogy of strains. The clustering of mycoplasma positive strains may be an experimental artifact, caused by shared RAPD characters which are dependent on the presence of mycoplasma DNA.
        
        
          Conclusions
          Our results confirmed both the suitability of the RAPD technique for genealogical studies in T. vaginalis and previous conclusions on the relatedness of metronidazol resistant strains. However, our studies indicate that testing analysed strains for the presence of endobionts and assessment of the robustness of tree topologies by bootstrap analysis seem to be obligatory steps in such analyses.

Tags: genetic-relatedness, metronidazole-resistance, nih, rapd-analysis, trichomonas-vaginalis
Organization: U.S. Department of Health & Human Services
2014-2016 Substate Estimates of Substance Use and Mental Illness

Substate estimates for 15 measures of substance use and mental illness based on the combined 2014, 2015, and 2016 National Surveys on Drug Use and Health (NSDUHs) are provided. NSDUH is an ongoing survey of the civilian, noninstitutionalized population of the United States aged 12 years or older. Estimates presented here are based on a small area estimation (SAE) methodology in which substate-level NSDUH data are combined with county and census block group/tract-level data from the state.

Tags: mental-illness, nsduh-data, samhsa, small-area-estimation, substance-use
Organization: U.S. Department of Health & Human Services
Patent AT-E400201-T1: [Translated] SHOE

The invention relates to a shoe ( 1 ), especially a sports shoe, comprising a sole ( 2 ) and a shoe upper part ( 3 ) linked therewith, the sole ( 2 ) having a receptacle ( 4 ) in which a damping element ( 5 ) is detachably arranged. The aim of the invention is to improve the cushioning and damping behavior of the shoe. According to the Invention, the receptacle ( 4 ) substantially or completely extends through the sole ( 2 ) at an angle to the longitudinal axis (L) of the shoe ( 1 ) and the detachably mounted damping element ( 5 ) is constituted of a plate-type base ( 6 ) that comprises a plurality of recesses ( 7 ) in which damping parts ( 8 ) can be disposed. The recesses ( 7 ) in the damping element ( 5 ) extend across the entire height (H) of the damping element ( 5 ) in the vertical direction (V).

Tags: chemistry, innovation, patent, pubchem, research
Organization: U.S. Department of Health & Human Services
Patent AT-E399793-T1: [Translated] COMPOUNDS AND METHODS FOR THERAPY AND DIAGNOSIS OF LUNG CANCER

Compounds and methods for the treatment and diagnosis of lung cancer are provided. The inventive compounds include polypeptides containing at least a portion of a lung tumor protein. Vaccines and pharmaceutical compositions for immunotherapy of lung cancer comprising such polypeptides, or DNA molecules encoding such polypeptides, are also provided, together with DNA molecules for preparing the inventive polypeptides.

Tags: chemistry, innovation, patent, pubchem, research
Organization: U.S. Department of Health & Human Services
Compound 525855: N,N-Dimethyl-2-phenyl-N'-(4-ethoxyphenyl)-acetamidine

Chemical compound data from PubChem database. IUPAC Name: N'-(4-ethoxyphenyl)-N,N-dimethyl-2-phenylethanimidamide. Molecular Formula: C18H22N2O. Molecular Weight: 282.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 529315: 3-Methyloxetane

Chemical compound data from PubChem database. IUPAC Name: 3-methyloxetane. Molecular Formula: C4H8O. Molecular Weight: 72.11. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Patent AT-E400760-T1: [Translated] SYSTEM AND METHOD FOR USING BENT TUBES IN A HIGH PURITY LIQUID TREATMENT SYSTEM

A novel method (500) for bending tubes (102; 410; 412; 414) suitable for use in high-purity fluid handling systems (400) includes selecting (502) a tube (102; 410; 412; 414) made from a material having a grain-size number of at least 5, and forming (504) a bend (104) in the tube with a bend radius (108) of greater than 1.5 times the diameter of the tube (102; 410; 412; 414). Tubes (102; 410; 412; 414) bent according to the present invention are incorporated into high-purity systems (400) as supply lines, product lines, and vacuum forelines, without the need for post-bend heat treatment or polishing (Fig. 5).

Tags: chemistry, innovation, patent, pubchem, research
Organization: U.S. Department of Health & Human Services
Compound 529976: Heptadecane, 6-pentyl

Chemical compound data from PubChem database. IUPAC Name: 6-pentylheptadecane. Molecular Formula: C22H46. Molecular Weight: 310.6. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 526897: 2-(2-Isopentoxyethoxy)ethyl acetate

Chemical compound data from PubChem database. IUPAC Name: 2-[2-(3-methylbutoxy)ethoxy]ethyl acetate. Molecular Formula: C11H22O4. Molecular Weight: 218.29. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2017 Uniform Reporting System (URS) Table for Ohio

This is the 2017 Uniform Reporting System (URS) Output Tables for Ohio. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: evidence-based-practices, mental-health-services, national-outcome-measures, samhsa, utilization-measures
Organization: U.S. Department of Health & Human Services
Patent AT-E401038-T1: [Translated] AUTOMATIC LUNG PARAMETERS ESTIMATION

A device for determining one or more respiratory parameters relating to an individual is disclosed, as well as a method for determining one or more respiratory parameters by means of the device, wherein the individual is suffering from hypoxemia or is at risk of hypoxemia. However, the method and the device may also be applied to healthy individual e.g. for testing of medicaments. The device is controlled by a computer equipped with suitable software and includes functionality for on-line continuous data collection, automatic assessment of the timing of measurements, automatic assessment of the next target (oxygen saturation of arterial blood (SpO2)), automatic assessment of the appropriate fraction of oxygen in inspired gas (FIO2) settings to achieve the target SpO2, automatic control of the FIO2, on-line parameter estimation, and automatic assessment of the number of measurememts requied.

Tags: chemistry, innovation, patent, pubchem, research
Organization: U.S. Department of Health & Human Services
Is succinylcholine appropriate or obsolete in the intensive care unit?

Muscle relaxants in intensive care unit (ICU) patients are predominantly administered to facilitate intubation. The adverse effect profile of succinylcholine is such that its use in the ICU must be considered obsolete. Suitable alternatives are the intermediately long-acting nondepolarizing relaxants, of which rocuronium is probably preferable.

Tags: intensive-care, intubation, muscle-relaxants, nih, succinylcholine
Organization: U.S. Department of Health & Human Services
Compound 528577: tert-Butyl(dimethyl)silyl heptadecanoate

Chemical compound data from PubChem database. IUPAC Name: [tert-butyl(dimethyl)silyl] heptadecanoate. Molecular Formula: C23H48O2Si. Molecular Weight: 384.7. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Expression of p53, inducible nitric oxide synthase and vascular endothelial growth factor in gastric precancerous and cancerous lesions: correlation with clinical features

Background
          The growth and metastasis of tumors depend on the development of an adequate blood supply via angiogenesis. Recent studies indicate that the inducible nitric oxide synthase (iNOS), vascular endothelial growth factor (VEGF) and the tumor suppressor p53 are fundamental play-markers of the angiogenic process. Overexpression of iNOS and VEGF has been shown to induce angiogenesis in tumors. P53 suppresses angiogenesis by down-regulating VEGF and iNOS. The correlation of expression of p53, VEGF and iNOS and clinical features in gastric carcinogenesis, however, has not been well characterized.
        
        
          Methods
          The expression of p53, iNOS and VEGF in gastric precancerous and cancerous lesions and its relation with the clinical features was determined with immunohistochemistry (avidin-biotin-peroxidase complex method) on 55 randomly selected GC patients and 60 symptom-free subjects from the mass survey in the high-incidence area for GC in Henan, northern China.
        
        
          Results
          The positive immunostainig rates for p53, iNOS and VEGF in gastric carcinomas were 51%, 44% and 51%, respectively, and correlated well with TNM stages, but did not show significant difference among the groups with different degrees of gastric wall invasion depth by GC. A positive immunostaining reaction for the iNOS protein was significantly correlated with lymph node metastasis (p = 0.019; Spearman correlation coefficient). P53 protein accumulation was higher in the poorly-differentiated gastric carcinoma than in well-differentiated one. In gastric biopsies, no positive immunosatining was observed for p53, iNOS and VEGF in the histologically normal tissue and chronic superficial gastritis (CSG). However, p53, iNOS and VEGF positive immunostaining was observed in the tissues with different severities of lesions of chronic atrophic gastritis (CAG), intestinal metaplasia (IM) and dysplasia (DYS), and the positive rates increased with the lesion progression from CAG to IM to DYS. A high coincidental positive and negative immunostaining rate for p53, iNOS and VEGF was observed both in biopsy samples with CAG, IM and DYS from the symptom-free subjects and in gastric cancer tissue from the GC patients.
        
        
          Conclusions
          The present results indicated that p53 protein accumulation and increased expression of iNOS and VEGF might be responsible for gastric carcinogenesis and tumor aggressiveness of gastric cancer.

Tags: gastric-cancer, immunohistochemistry, inos-vegf-p53, nih, tumor-angiogenesis
Organization: U.S. Department of Health & Human Services
Mental Health Service Use Among Adults Not Classified as Having Any Mental Illness In the National Survey on Drug Use and Health

This report examines the types and nature of mental health services used by adults who do not meet criteria for AMI and the potential reasons that may account for individuals using mental health services without meeting these criteria in NSDUH.

Tags: mental-health-services, non-ami-adults, nsduh, samhsa, service-utilization
Organization: U.S. Department of Health & Human Services
Patent AT-E399930-T1: [Translated] THERMAL STORAGE SYSTEM FOR A LARGE AMOUNT OF ENERGY AND ITS SHORT-TERM USE ON A SHIP

The large quantity energy storage system short period freeing energy has a principal cylinder (3) containing a large quantity of liquid such as water. A heat exchanger (4) in the cylinder is fed with hot exhaust gas from a thermodynamic machine such as a gas turbine. The water is stored at high pressure between 220-400 bar and at a temperature of about 600 degrees C. The stored water can be used to quickly power a hydrojet.

Tags: chemistry, innovation, patent, pubchem, research
Organization: U.S. Department of Health & Human Services
Compound 526186: 2-(2-Furyl)thiazole

Chemical compound data from PubChem database. IUPAC Name: 2-(furan-2-yl)-1,3-thiazole. Molecular Formula: C7H5NOS. Molecular Weight: 151.19. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 530563: m-Toluic acid, hexadecyl ester

Chemical compound data from PubChem database. IUPAC Name: hexadecyl 3-methylbenzoate. Molecular Formula: C24H40O2. Molecular Weight: 360.6. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Patent AT-E401792-T1: [Translated] BAKERY YEASTS WITH IMPROVED TOLERANCE TO HIGH SUGAR CONTENT IN DOUGH AND TO WEAK ORGANIC ACIDS

Breadmaking yeast which is a variety of Saccharomyces cerevisiaeas submitted to the CNCM (Collection Nationale de Cultures de Micro-organisms, Institut Pasteur) on 12 February and 25 November 2003 under the following numbers: I-2971, I-3142, I-3143, or other varieties of the same family, is new. Breadmaking yeast which is a variety of Saccharomyces cerevisiaeas submitted to the CNCM (Collection Nationale de Cultures de Micro-organisms, Institut Pasteur) on 12 February and 25 November 2003 under the following numbers: I-2971, I-3142, I-3143, or other varieties of the same family, is new. The yeast is used for making a dough in which fermentation is carried out in the presence of osmotic pressure similar to that occurring in doughs with a sugar content of at least 15 per cent relative to the amount of flour, and preferably 40 per cent, and containing mould inhibitors. The mould inhibitors are preferably in the form of weal organic acids or their salts, and especially calcium propionate.

Tags: chemistry, innovation, patent, pubchem, research
Organization: U.S. Department of Health & Human Services
Compound 528174: 1,3-Cyclopentadiene, 2-butyl

Chemical compound data from PubChem database. IUPAC Name: 2-butylcyclopenta-1,3-diene. Molecular Formula: C9H14. Molecular Weight: 122.21. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Patent AT-E400507-T1: [Translated] DEVICE FOR STORING AND TRANSPORTING GOODS AND INSERTS THEREOF

At least one insert ( 6 ) for insertion into a bag ( 3 ) for receiving a discrete article, said insert ( 6 ) being preferably located in a portion of the bag taking up substantially the main load of the discrete article and being moveable relative to the bag, securable to the bag and removable from the bag. The invention also includes a device for storing and transporting discrete articles, having at least one bag ( 3 ) in which the discrete article can be received, wherein it comprises at least one insert ( 6 ), as described above, in the region of the bag ( 3 ) taking up substantially the main load of the discrete article, said insert being movable relative to the bag and detachably secured to the bag ( 3 ).

Tags: chemistry, innovation, patent, pubchem, research
Organization: U.S. Department of Health & Human Services
Compound 528380: 2,3-Dichloro-4-hydroxybenzaldehyde

Chemical compound data from PubChem database. IUPAC Name: 2,3-dichloro-4-hydroxybenzaldehyde. Molecular Formula: C7H4Cl2O2. Molecular Weight: 191.01. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 526028: 17A-11-Dehydroestradiol, TMS

Chemical compound data from PubChem database. IUPAC Name: trimethyl-[(13-methyl-3-trimethylsilyloxy-6,7,8,9,14,15,16,17-octahydrocyclopenta[a]phenanthren-17-yl)oxy]silane. Molecular Formula: C24H38O2Si2. Molecular Weight: 414.7. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Patent AT-E39991-T1: [Translated] SAFETY LOCKING DEVICE ON GUARDS TO PREVENT INTERVENTION IN HAZARDOUS SPACES.

1. Device for safety interlocking in protection equipment for preventing reaching into spaces which are dangerous, particularly in the came of machines with dangerous movements or with current-carrying equipment in housings, whereby a toggle lever (14, 15) is provided with a pivoted locking lever (8), which is provided with two dead centre positions and which interacts with an actuating part (9) being mounted stationary on the protection device (5) and being provided with a locking cam, in such a way that in the one dead centre position of the toggle lever (14, 15) the locking lever (8) and the actuating part (9) interlock with each other and the dangerous operating condition may be switched on, and that in the other dead centre position the dangerous operating condition is switched off and the actuating part (9) with the protection device (5) is released, characterised in that a pull lever (19) is linked to the centre joint (14a) of the toggle lever (14, 15), said pull lever being connected to the anchor (18a) of a holding magnet (18) by means of a joint (18b).

Tags: chemistry, innovation, patent, pubchem, research
Organization: U.S. Department of Health & Human Services