AndreaBozzo/ceres-open-data-index huggingface dataset:
New York City – 5 Boros: Drug-Related Emergency Department Visits, 2004-2011 - Nonmedical Use of Pharmaceuticals

Excel file with estimates, rates, relative standard errors, trends and confidence intervals for all drug-related emergency department (ED) visits involving the nonmedical use of pharmaceuticals (prescription and over-the-counter medications and dietary supplements) for the New York City 5 boroughs, covering 2004-2011.  Nonmedical use includes patients who took a higher than prescribed or recommended dose of their own medication, patients who took a pharmaceutical prescribed for another person, malicious poisoning of the patient by another individual, and documented substance abuse involving pharmaceuticals

Tags: emergency-department, nyc-boroughs, pharmaceutical-misuse, prescription-drug-abuse, samhsa
Organization: U.S. Department of Health & Human Services
Compound 527300: Propyl heptadecanoate

Chemical compound data from PubChem database. IUPAC Name: propyl heptadecanoate. Molecular Formula: C20H40O2. Molecular Weight: 312.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 528461: 1-Tetradecene, 12-ethyl

Chemical compound data from PubChem database. IUPAC Name: 12-ethyltetradec-1-ene. Molecular Formula: C16H32. Molecular Weight: 224.42. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Table 5. 2011-2012 NSDUH First Use of Marijuana, by Age Group and State

Table 5. First Use of Marijuana, by Age Group and State: Average Annual Rates Based on 2011 and 2012 NSDUHs. Results are provided by State and for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: adolescent-health, marijuana-initiation, nsduh-data, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
The cohesin complex: sequence homologies, interaction networks and shared motifs

Background:
          Cohesin is a macromolecular complex that links sister chromatids together at the metaphase plate during mitosis. The links are formed during DNA replication and destroyed during the metaphase-to-anaphase transition. In budding yeast, the 14S cohesin complex comprises at least two classes of SMC (structural maintenance of chromosomes) proteins - Smc1 and Smc3 - and two SCC (sister-chromatid cohesion) proteins - Scc1 and Scc3. The exact function of these proteins is unknown.
        
        
          Results:
          Searches of protein sequence databases have revealed new homologs of cohesin proteins. In mouse, Mmip1 (Mad member interacting protein 1) and Smc3 share 99% sequence identity and are products of the same gene. A phylogenetic tree of SMC homologs reveals five families: Smc1, Smc2, Smc3, Smc4 and an ancestral family that includes the sequences from the Archaea and Eubacteria. This ancestral family also includes sequences from eukaryotes. A cohesion interaction network, comprising 17 proteins, has been constructed using two proteomic databases. Genes encoding six proteins in the cohesion network share a common upstream region that includes the MluI cell-cycle box (MCB) element. Pairs of the proteins in this network share common sequence motifs that could represent common structural features such as binding sites. Scc2 shares a motif with Chk1 (kinase checkpoint protein), that comprises part of the serine/threonine protein kinase motif, including the active-site residue.
        
        
          Conclusions:
          We have combined genomic and proteomic data into a comprehensive network of information to reach a better understanding of the function of the cohesin complex. We have identified new SMC homologs, created a new SMC phylogeny and identified shared DNA and protein motifs. The potential for Scc2 to function as a kinase - a hypothesis that needs to be verified experimentally - could provide further evidence for the regulation of sister-chromatid cohesion by phosphorylation mechanisms, which are currently poorly understood.

Tags: cohesin-complex, nih, protein-homology, sister-chromatid-cohesion, smc-proteins
Organization: U.S. Department of Health & Human Services
Child and Family Services Reviews Update Volume 17, Issue 2, March 2023

This issue of Child and Family Services Reviews Update contains the following sections: Round 4 Year 1 States are Gearing Up, New Mock Case Course Released on E-Learning Academy, Spanish Translations Added to Portal, New Round 4 FAQs Posted, and Child Welfare Reviews Project Upcoming Presentations.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: assessment, child, data, policy, scope
Organization: U.S. Department of Health & Human Services
Mast cell activation and its relation to proinflammatory cytokine
		  production in the rheumatoid lesion

Mast cell (MC) activation in the rheumatoid lesion provides numerous
			 mediators that contribute to inflammatory and degradative processes, especially
			 at sites of cartilage erosion. MC activation in rheumatoid synovial tissue has
			 often been associated with tumour necrosis factor (TNF)-α and interleukin
			 (IL)-1β production by adjacent cell types. By contrast, our in
			 situ and in vitro studies have shown that the production of IL-15
			 was independent of MC activation, and was not related to TNF-α and
			 IL-1β expression. Primary cultures of dissociated rheumatoid synovial
			 cells produced all three proinflammatory cytokines, with production of
			 IL-1β exceeding that of TNF-α, which in turn exceeded that of IL-15.
			 In vitro cultures of synovial macrophages, synovial fibroblasts and
			 articular chondrocytes all produced detectable amounts of free IL-15,
			 macrophages being the most effective.

Tags: mast-cell-activation, nih, proinflammatory-cytokines, rheumatoid-arthritis, tnf-alpha
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Vermont, 2013

This is a behavioral health report for the state of Vermont. It uses the  National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment Services (NSSATS) to address the topics of youth substance use , youth mental health and treatment, adult mental health and treatment, substance use, substance use treatment for the years 2008 to 2012.

Tags: adult-mental-health, samhsa, substance-use-treatment, vermont-behavioral-health, youth-substance-use
Organization: U.S. Department of Health & Human Services
Should all patients receive dual chamber pacing ICDs? The rationale for the DAVID trial

All of the prospective multicenter trials that support the use of implantable defibrillators have used single chamber pacemakers/implantable cardiovertor defibrillators (ICDs). Despite the significantly increased cost of dual chamber pacemaker/ICD devices and the lack of outcome data, these devices accounted for approximately two-thirds of the ICDs implanted in the United States during the 12 months ending April 2001. Dual chamber pacemaker trials have not provided data that would support this trend, but the high incidence of atrial fibrillation, bradycardia, and congestive heart failure, as comorbid conditions, suggest that the situation could be different in the defibrillator patient population. The DAVID (Dual Chamber and VVI Implantable Defibrillator) trial is designed to measure the incremental benefit of dual chamber pacemaker/ICDs.

Tags: arrhythmia-treatment, david-trial, dual-chamber-pacing, icd-therapy, nih
Organization: U.S. Department of Health & Human Services
Guidance on Flexible Convening of Court Hearings During COVID-19

This letter urges attorneys, courts, Court Improvement Programs, and administrative offices of the courts to work together to ensure that requisite judicial proceedings continue during the COVID-19 pandemic.

Browse All COVID-19 Resources

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: 19, covid, guidance, instruction, policy
Organization: U.S. Department of Health & Human Services
2017 Uniform Reporting System (URS) Table for Washington

This is the 2017 Uniform Reporting System (URS) Output Tables for Washington. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: behavioral-health, block-grant-data, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
High frequency of phenotypic deviations in

Background
          The moss Physcomitrella patens is an attractive model system for plant biology and functional genome analysis. It shares many biological features with higher plants but has the unique advantage of an efficient homologous recombination system for its nuclear DNA. This allows precise genetic manipulations and targeted knockouts to study gene function, an approach that due to the very low frequency of targeted recombination events is not routinely possible in any higher plant.
        
        
          Results
          As an important prerequisite for a large-scale gene/function correlation study in this plant, we are establishing a collection of Physcomitrella patens transformants with insertion mutations in most expressed genes. A low-redundancy moss cDNA library was mutagenised in E. coli using a derivative of the transposon Tn1000. The resulting gene-disruption library was then used to transform Physcomitrella. Homologous recombination of the mutagenised cDNA with genomic coding sequences is expected to target insertion events preferentially to expressed genes. An immediate phenotypic analysis of transformants is made possible by the predominance of the haploid gametophytic state in the life cycle of the moss. Among the first 16,203 transformants analysed so far, we observed 2636 plants ( = 16.2%) that differed from the wild-type in a variety of developmental, morphological and physiological characteristics.
        
        
          Conclusions
          The high proportion of phenotypic deviations and the wide range of abnormalities observed among the transformants suggests that mutagenesis by gene-disruption library transformation is a useful strategy to establish a highly diverse population of Physcomitrella patens mutants for functional genome analysis.

Tags: gene-disruption, homologous-recombination, moss-genetics, nih, physcomitrella-patens
Organization: U.S. Department of Health & Human Services
2016 Uniform Reporting System (URS) Table for Republic of Marshall Islands

This is the 2016 Uniform Reporting System (URS) Output Tables for Republic of Marshall Islands. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-program, community-mental-health, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Decreased expression of the mannose 6- phosphate/insulin-like growth factor-II receptor promotes growth of human breast cancer cells

Background
          Loss or mutation of the mannose 6-phosphate/insulin-like growth factor-II receptor (M6P/IGF2R) has been found in breast cancer. However, whether or not decreased levels of functional M6P/IGF2R directly contribute to the process of carcinogenesis needs to be further verified by functional studies.
        
        
          Methods
          In this study, using viral and ribozyme strategies we reduced the expression of M6P/IGF2R in human breast cancer cells and then examined the effect on growth and apoptosis of these cells.
        
        
          Results
          Our results showed that infection of MCF-7 cells with the adenovirus carrying a ribozyme targeted against the M6P/IGF2R mRNA dramatically reduced the level of transcripts and the functional activity of M6P/IGF2R in these cells. Accordingly, cells treated with the ribozyme exhibited a higher growth rate and a lower apoptotic index than control cells (infected with a control vector). Furthermore, decreased expression of M6P/IGF2R enhanced IGF-II-induced proliferation and reduced cell susceptibility to TNF-induced apoptosis.
        
        
          Conclusions
          These results suggest that M6P/IGF2R functions as a growth suppressor and its loss or mutation may contribute to development and progression of cancer. This study also demonstrates that adenoviral delivery of the ribozyme provides a useful tool for investigating the role of M6P/IGF2R in regulation of cell growth.

Tags: apoptosis, breast-cancer, cell-growth, m6pigf2r-receptor, nih
Organization: U.S. Department of Health & Human Services
Publications Using SAMHSA Data2021 Uniform Reporting System (URS) Table For Virgin Islands

This is the 2021 Uniform Reporting System (URS) Output Tables for Virgin Islands. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: mental-health-services, outcome-measures, samhsa, urs-data, virgin-islands
Organization: U.S. Department of Health & Human Services
Supplemental Disaster Relief Funding available under Title IV-B, Subpart 1 of the Act

This Program Instruction (PI) provides guidance to agencies administering title IV-B, subpart 1 on the actions required to apply for funding to address child welfare needs relating to disaster recovery in areas affected by Hurricanes Fiona and Ian.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: disaster, guidance, instruction, mental, policy
Organization: U.S. Department of Health & Human Services
Publications Using SAMHSA Data2022 Uniform Reporting System (URS) Table For Puerto Rico

This is the 2022 Uniform Reporting System (URS) Output Tables for Puerto Rico. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant, mental-health-services, outcome-measures, puerto-rico, samhsa
Organization: U.S. Department of Health & Human Services
2012 State Profile - Colorado

This is a National Survey of Substance Abuse Treatment Services (N-SSATS) annual report showing the state profile for Colorado in 2012. N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 States, the District of Columbia, and other U.S. jurisdictions.

Tags: colorado, n-ssats, samhsa, substance-abuse-treatment, treatment-facilities
Organization: U.S. Department of Health & Human Services
MaryLee Allen Promoting Safe and Stable Families

The MaryLee Allen Promoting Safe and Stable Families (PSSF) program provides formula grants each year to states, territories and approximately 135-145 tribes. The purpose of this program is to prevent child maltreatment and the unnecessary separation of children from their families, improve the quality of care and services to children and their families, and ensure permanency for children by reuniting them with their parents, or by promoting adoption or another permanent living arrangement.  Funding may be used to develop, establish, or expand, and to operate coordinated programs of community-based family support services, family preservation services, family reunification services, and adoption promotion and support services.

The statute also reserves funding for other grants and activities, including Regional Partnership Grants (RPGs); state grants for caseworker visits; Court Improvement Program grants; evaluation, research, and technical assistance.  In fiscal years (FYs) 2018 — 2024 the appropriations for PSSF also included funding to help title IV-E agencies develop, expand or evaluate kinship navigator programs.

Budget Information

The PSSF program receives both mandatory and discretionary appropriations.

FY 2024 Funding:

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: adoption, child, grant, maltreatment, policy
Organization: U.S. Department of Health & Human Services
Publications Using SAMHSA DataLas Vegas-Paradise, NV

This report presents combined 2005 to 2010 National Survey on Drug Use and Health (NSDUH) results for those aged 12 or older in the Las Vegas-Paradise, NM metro area. The report includes estimates of substance use disorder, major depressive episode, illicit drug use, marijuana use, cigarette use, binge alcohol use, and the nonmedical use of prescription-type pain relievers. Results are provided for the Las Vegas-Paradise metro area, New Mexico, and the U.S. overall.

Tags: las-vegas, major-depressive-episode, nsduh-data, samhsa, substance-use-disorder
Organization: U.S. Department of Health & Human Services
Compound 525682: N-(4-Chlorobenzylidene)-P-phenetidine

Chemical compound data from PubChem database. IUPAC Name: 1-(4-chlorophenyl)-N-(4-ethoxyphenyl)methanimine. Molecular Formula: C15H14ClNO. Molecular Weight: 259.73. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Gamma oscillation underlies hyperthermia-induced epileptiform-like spikes in immature rat hippocampal slices

Background
          Recently a hyperthermic rat hippocampal slice model system has been used to investigate febrile seizure pathophysiology. Our previous data indicates that heating immature rat hippocampal slices from 34 to 41°C in an interface chamber induced epileptiform-like population spikes accompanied by a spreading depression (SD). This may serve as an in vitro model of febrile seizures.
        
        
          Results
          In this study, we further investigate cellular mechanisms of hyperthermia-induced initial population spike activity. We hypothesized that GABAA receptor-mediated 30–100 Hz γ oscillations underlie some aspects of the hyperthermic population spike activity. In 24 rat hippocampal slices, the hyperthermic population spike activity occurred at an average frequency of 45.9 ± 14.9 Hz (Mean ± SE, range = 21–79 Hz, n = 24), which does not differ significantly from the frequency of post-tetanic γ oscillations (47.1 ± 14.9 Hz, n = 34) in the same system. High intensity tetanic stimulation induces hippocampal neuronal discharges followed by a slow SD that has the magnitude and time course of the SD, which resembles hyperthermic responses. Both post-tetanic γ oscillations and hyperthermic population spike activity can be blocked completely by a specific GABAA receptor blocker, bicuculline (5–20 μM). Bath-apply kynurenic acid (7 mM) blocks synaptic transmission, but fails to prevent hyperthermic population spikes, while intracellular diffusion of QX-314 (30 mM) abolishes spikes and produces a smooth depolarization in intracellular recording.
        
        
          Conclusion
          These results suggest that the GABAA receptor-governed γ oscillations underlie the hyperthermic population spike activity in immature hippocampal slices.

Tags: febrile-seizures, gamma-oscillation, hippocampal-slices, hyperthermia, nih
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Mississippi, 2014

This is a behavioral health report for the state of Mississippi . It uses the National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment Services (NSSATS) to address the topics of youth substance use, youth mental health and treatment, adult mental health and treatment, substance use, and substance use treatment for the years 2009 to 2013.

Tags: behavioral-health, mental-health, mississippi, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
San Francisco-Oakland-Fremont, CA

This report presents combined 2005 to 2010 National Survey on Drug Use and Health (NSDUH) results for those aged 12 or older in the San Francisco-Oakland-Fremont, CA metro area. The report includes estimates of substance use disorder, major depressive episode, illicit drug use, marijuana use, cigarette use, binge alcohol use, and the nonmedical use of prescription-type pain relievers. Results are provided for the San Francisco-Oakland-Fremont metro area, California, and the U.S. overall.

Tags: alcohol-abuse, major-depression, nsduh-data, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
2020 Uniform Reporting System (URS) Table For North Dakota

This is the 2020 Uniform Reporting System (URS) Output Tables for North Dakota. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-data, mental-health-services, noms-measures, north-dakota, samhsa
Organization: U.S. Department of Health & Human Services
Molecular archeology of an SP100 splice variant revisited: dating the retrotranscription and

Background
          SP100 is a nuclear protein that displays a number of alternative splice variants. In Old World monkeys, apes and humans one of these variants is extended by a retroprocessed pseudogene, HMG1L3, whose antecedent gene is a member of the family of high-mobility-group proteins, HMG1. This is one of only a few documented cases of a retropseudogene being incorporated into another gene as a functional exon. In addition to the HMG1L3 insertion, Old World monkey genomes also contain an Alu sequence within the last SP100-HMG intron. PCR amplification of the 3' end of the SP100 gene using genomic DNAs from human and New World and Old World monkey species, followed by direct sequencing of the amplicons has made dating the HMG1L3 and Alu insertion events possible.
        
        
          Results
          PCR amplifications confirm that the HMG1L3 retrotransposition into the SP100 locus occurred after divergence of New World and Old World monkey lineages, some 35-40 million years ago. PCR amplification also shows that an upstream Alu sequence was inserted in the last SP100-HMG intron after divergence of the Old World monkey and ape lineages. Direct sequencing of the Alu in five Old World monkey species places the latter event at around 19 million years ago. Finally, ten single base mutations and one deletion in the Alu differentiate African from Asian Old World monkey species.
        
        
          Conclusions
          PCR and DNA sequence analysis of 'genetic fossils' such as retropseudogenes and Alu elements in primates give details as to the timing of such events and can reveal sequence features useful for other molecular phylogenetic applications.

Tags: genome-evolution, hmg1l3-retrotransposition, molecular-archeology, nih, sp100-protein
Organization: U.S. Department of Health & Human Services