AndreaBozzo/ceres-open-data-index huggingface dataset:
Compound 528600: tert-Butyl(dimethyl)silyl tridecanoate

Chemical compound data from PubChem database. IUPAC Name: [tert-butyl(dimethyl)silyl] tridecanoate. Molecular Formula: C19H40O2Si. Molecular Weight: 328.6. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Generation of single-copy transgenic mouse embryos directly from ES cells by tetraploid embryo complementation

Background
          Transgenic mice have been used extensively to analyze gene function. Unfortunately, traditional transgenic procedures have only limited use in analyzing alleles that cause lethality because lines of founder mice cannot be established. This is frustrating given that such alleles often reveal crucial aspects of gene function. For this reason techniques that facilitate the generation of embryos expressing such alleles would be of enormous benefit. Although the transient generation of transgenic embryos has allowed limited analysis of lethal alleles, it is expensive, time consuming and technically challenging. Moreover a fundamental limitation with this approach is that each embryo generated is unique and transgene expression is highly variable due to the integration of different transgene copy numbers at random genomic sites.
        
        
          Results
          Here we describe an alternative method that allows the generation of clonal mouse embryos harboring a single-copy transgene at a defined genomic location. This was facilitated through the production of Hprt negative embryonic stem cells that allow the derivation of embryos by tetraploid embryo complementation. We show that targeting transgenes to the hprt locus in these ES cells by homologous recombination can be efficiently selected by growth in HAT medium. Moreover, embryos derived solely from targeted ES cells containing a single copy LacZ transgene under the control of the α-myosin heavy chain promoter exhibited the expected cardiac specific expression pattern.
        
        
          Conclusion
          Our results demonstrate that tetraploid embryo complementation by F3 hprt negative ES cells facilitates the generation of transgenic mouse embryos containing a single copy gene at a defined genomic locus. This approach is simple, extremely efficient and bypasses any requirement to generate chimeric mice. Moreover embryos generated by this procedure are clonal in that they are all derived from a single ES cell lines. This facilitates the comparative analysis of lethal alleles and thereby advances our ability to analyze gene function in mammals.

Tags: embryo-complementation, gene-function, lethal-alleles, nih, transgenic-mice
Organization: U.S. Department of Health & Human Services
Detroit: Drug-Related Emergency Department Visits, 2004-2011 - All Misuse and Abuse

Excel file with estimates, rates, relative standard errors, trends and confidence intervals for all drug-related emergency department (ED) visits involving drug misuse or abuse in the Detroit metropolitan area, covering 2004-2011. Drug misuse/abuse visits include the use of illicit drugs, nonmedical use of pharmaceuticals, underage drinking and visits where alcohol was combined with another drug.

Tags: detroit-metro-area, drug-related-ed-visits, emergency-department, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
ACF and DOL webinar on Child Labor Exploitation

The Administration for Children and Families (ACF) and the Department of Labor’s (DOL) Wage and Hour Division hosted a webinar providing an overview of the Division and the laws and outreach behind its mission. Learn how the agency promotes and achieves compliance with labor standards to protect the welfare of the nation's workforce. The presentation focuses on child labor laws and ways in which child labor investigations are conducted, and participants learned how the public can file a complaint.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: child, compliance, guidance, labor, policy
Organization: U.S. Department of Health & Human Services
Cytokines as new treatment targets in chronic heart failure

Inflammatory cytokines may negatively influence contractility and contribute to the remodelling process in the failing myocardium. Traditional cardiovascular drugs appear to have little influence on the overall cytokine network in chronic heart failure (CHF). Increased interest in anticytokine therapy has therefore evolved. Several small studies have used tumour necrosis factor (TNF)-α as a target, resulting in improved functional capacity and myocardial performance. Intravenous immunoglobulin (IVIG) represents another therapeutic approach in which the impact on myocardial performance appears to be correlated with anti-inflammatory effects. These studies demonstrate potential for immunomodulation as a therapy in addition to conventional cardiovascular treatment in CHF, but the most effective drugs in this regard have yet to be identified.

Tags: cytokine-therapy, heart-failure, immunomodulation, myocardial-remodeling, nih
Organization: U.S. Department of Health & Human Services
2022 Uniform Reporting System (URS) Table For Arkansas

This is the 2022 Uniform Reporting System (URS) Output Tables for Arkansas. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: arkansas-health, mental-health-services, national-outcome-measures, samhsa, substance-abuse-treatment
Organization: U.S. Department of Health & Human Services
Compound 527217: Isointermedeol

Chemical compound data from PubChem database. IUPAC Name: 1,4a-dimethyl-7-prop-1-en-2-yl-2,3,4,5,6,7,8,8a-octahydronaphthalen-1-ol. Molecular Formula: C15H26O. Molecular Weight: 222.37. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 525508: 7-Methyl-4-thia-1-octyne

Chemical compound data from PubChem database. IUPAC Name: 3-methyl-1-prop-2-ynylsulfanylbutane. Molecular Formula: C8H14S. Molecular Weight: 142.26. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
A novel link between the proteasome pathway and the signal transduction pathway of the Bone Morphogenetic Proteins (BMPs)

Background
          The intracellular signaling events of the Bone Morphogenetic Proteins (BMPs) involve the R-Smad family members Smad1, Smad5, Smad8 and the Co-Smad, Smad4. Smads are currently considered to be DNA-binding transcriptional modulators and shown to recruit the master transcriptional co-activator CBP/p300 for transcriptional activation. SNIP1 is a recently discovered novel repressor of CBP/p300. Currently, the detailed molecular mechanisms that allow R-Smads and Co-Smad to co-operatively modulate transcription events are not fully understood.
        
        
          Results
          Here we report a novel physical and functional link between Smad1 and the 26S proteasome that contributes to Smad1- and Smad4-mediated transcriptional regulation. Smad1 forms a complex with a proteasome β subunit HsN3 and the ornithine decarboxylase antizyme (Az). The interaction is enhanced upon BMP type I receptor activation and occur prior to the incorporation of HsN3 into the mature 20S proteasome. Furthermore, BMPs trigger the translocation of Smad1, HsN3 and Az into the nucleus, where the novel CBP/p300 repressor protein SNIP1 is further recruited to Smad1/HsN3/Az complex and degraded in a Smad1-, Smad4- and Az-dependent fashion. The degradation of the CBP/p300 repressor SNIP1 is likely an essential step for Smad1-, Smad4-mediated transcriptional activation, since increased SNIP1 expression inhibits BMP-induced gene responses.
        
        
          Conclusions
          Our studies thus add two additional important functional partners of Smad1 into the signaling web of BMPs and also suggest a novel mechanism for Smad1 and Smad4 to co-modulate transcription via regulating proteasomal degradation of CBP/p300 repressor SNIP1.

Tags: bmp-signaling, bone-morphogenetic-proteins, nih, proteasome-pathway, smad-proteins
Organization: U.S. Department of Health & Human Services
Compound 528514: Hexadecane, 4-nonyl

Chemical compound data from PubChem database. IUPAC Name: 10-propyldocosane. Molecular Formula: C25H52. Molecular Weight: 352.7. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Child and Family Services Reviews Update Volume 16, Issue 4, October 2022

This issue of Child and Family Services Reviews Update contains the following sections: Round 4 Year 1 Schedule, diverse agile staff sought for CFSRs, Round 4 Procedures Manual released, Round 4 Online Monitoring System (OMS) launched, Round 4 Data Profiles, visualizations released, new resources added to the CFSR Information Portal, and the Child Welfare Virtual Expo.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: assessment, child, family, manual, policy
Organization: U.S. Department of Health & Human Services
Compound 528368: Nornicotine, N-butanoyl

Chemical compound data from PubChem database. IUPAC Name: 1-(2-pyridin-3-ylpyrrolidin-1-yl)butan-1-one. Molecular Formula: C13H18N2O. Molecular Weight: 218.29. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
MCMV induces neointima in IFN-γR-/- mice: Intimal cell apoptosis and persistent proliferation of myofibroblasts

Background
          CMV infections have been linked to vasculopathies like atherosclerosis and Scleroderma. CMV infects vascular endothelium with intermittent shedding of the virus and the development of latency.
        
        
          Methods
          We adopted a model of arteritis, developed by Presti et al. (1998), triggered by murine cytomegalovirus (MCMV) infection. Our studies focused on neointima formation. Groups of mice include: 1) immunocompetent 129S, 2) immunocompetent 129S receiving whole body irradiation and MCMV, 3) IFN-γR-/- receiving MCMV, and 4) IFN-γR-/- receiving MCMV and whole body irradiation.
        
        
          Results
          Mice were inoculated with MCMV (5 x 104 or 1 x 105 PFU's) by i.p. injection; hearts and abdominal aortas were collected and histopathology evaluated. Infected immunocompetent animals exhibited widespread perivascular inflammation, which subsided by 8 weeks. Intimal pathology was not observed in any control group. Immunocompetent animals receiving MCMV and irradiation developed mild to moderate intimal lesions associated with medial and adventitial inflammation. IFN-γR-/- mice infected for 4 months and receiving whole body irradiation 2 months after infection developed pathology characterized by extensive adventitial and medial infiltrate and significant neointima, suggesting that infection and immunosuppression were co-requisites of neointima formation. Immunohistochemical analysis revealed myofibroblasts as a major component of neointima. The disease is characterized by up-regulation of growth factors (TGF-β1, PDGF-A and B). Apoptosis was detected in the intimal layer of affected aortas. Active proliferation of myofibroblasts and infiltrating cells was also detected.
        
        
          Conclusion
          These results indicate that CMV infections may lead to intimal injury that results in the formation of neointima characteristic of autoimmune vasculopathies.

Tags: ifn-gammar-mice, mcmv-infection, neointima-formation, nih, vascular-inflammation
Organization: U.S. Department of Health & Human Services
2013 NSDUH Risk and Protective Factors Tables  (Prevalence Estimates) - 3.1 to 3.25

These detailed tables present totals and prevalence estimates of risk and protective factors regarding substance use from the 2013 National Survey on Drug Use and Health (NSDUH). The factors include perceptions of 1) risk of substance use, 2) availability of substances, 3) parental disapproval of youth substance use, 4) peer substance use. They also include measures of delinquent behavior, religious involvement, exposure to prevention messages, and parental involvement. Results are provided by age group, gender, race/ethnicity, geographic area, and youth substance use behavior. Comparisons are made between 2013 and 2012.

Tags: nsduh-2013, protective-factors, samhsa, substance-use-risk, youth-drug-use
Organization: U.S. Department of Health & Human Services
Successful immunotherapy with matrix metalloproteinase-derived peptides in adjuvant arthritis depends on the timing of peptide administration

We have recently found that matrix metalloproteinases (MMPs) are targets for T-cell and B-cell reactivity in experimental arthritis. In the present article, we investigate whether modulation of MMP-specific T-cell responses could influence the course of adjuvant arthritis (AA). Lewis rats were treated nasally with MMP peptides prior to or after AA induction. Administration of the MMP-10 or the MMP-16 peptide prior to AA induction reduced the arthritic symptoms. In contrast, administration of the MMP-10 peptide after AA induction aggravated the arthritic symptoms. The present study shows the possible usefulness of MMP peptides for immunotherapy. However, a clear understanding of proper timing of peptide administration is crucial for the development of such therapies.

Tags: adjuvant-arthritis, immunotherapy-timing, lewis-rats, mmp-peptides, nih
Organization: U.S. Department of Health & Human Services
The role of chlorophyll

Background
          The physico-chemical properties of chlorophylls b and c have been known for decades. Yet the mechanisms by which these secondary chlorophylls support assembly and accumulation of light-harvesting complexes in vivo have not been resolved.
        
        
          Presentation
          Biosynthetic modifications that introduce electronegative groups on the periphery of the chlorophyll molecule withdraw electrons from the pyrrole nitrogens and thus reduce their basicity. Consequently, the tendency of the central Mg to form coordination bonds with electron pairs in exogenous ligands, a reflection of its Lewis acid properties, is increased. Our hypothesis states that the stronger coordination bonds between the Mg atom in chlorophyll b and chlorophyll c and amino acid sidechain ligands in chlorophyll a/b- and a/c-binding apoproteins, respectively, enhance their import into the chloroplast and assembly of light-harvesting complexes.
        
        
          Testing
          Several apoproteins of light-harvesting complexes, in particular, the major protein Lhcb1, are not detectable in leaves of chlorophyll b-less plants. A direct test of the hypothesis – with positive selection – is expression, in mutant plants that synthesize only chlorophyll a, of forms of Lhcb1 in which weak ligands are replaced with stronger Lewis bases.
        
        
          Implications
          The mechanistic explanation for the effects of deficiencies in chlorophyll b or c points to the need for further research on manipulation of coordination bonds between these chlorophylls and chlorophyll-binding proteins. Understanding these interactions will possibly lead to engineering plants to expand their light-harvesting antenna and ultimately their productivity.

Tags: chlorophyll-biosynthesis, chloroplast-assembly, light-harvesting-complexes, magnesium-coordination, nih
Organization: U.S. Department of Health & Human Services
2022-2023 NSDUH: Other Sources of State-Level Data

Compare state-level National Survey on Drug Use and Health (NSDUH) estimates with those from the Behavioral Risk Factor Surveillance System (BRFSS) from the Centers for Disease Control and Prevention. Comparisons are available for alcohol and cigarette use among people ages 18 or older.

Tags: alcohol-use, behavioral-risk-factors, cigarette-use, samhsa, state-level-data
Organization: U.S. Department of Health & Human Services
Validation Technical Training Video

This short, 8-minute technical training video is created by The Children's Bureau Data Analytics and Reporting Team and gives a brief demonstration which shows agencies how to validate their XML files against the XSD. For more information, or to access the XSD, please see AFCARS Technical Bulletin 21.

Audio Descriptive Version

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: agency, child, data, policy, reporting
Organization: U.S. Department of Health & Human Services
Fast relapse and high drop out rate of 48 weeks daily interferon monotherapy in HIV-infected patients with chronic hepatitis C

Background
          The standard of care for HCV Hepatitis is the combination of interferon (IFN) plus Ribavirin. In HIV patients the use of this combination therapy may induce drug interactions, and reduces the adherence to HAART.
          The aim of this study is to evaluate safety and efficacy of a 48 weeks daily dose IFN schedule.
        
        
          Methods
          We evaluated 50 coinfected patients; alpha IFN 2a was administered at a dose of 3 MU daily. The baseline values were the following : CD4+ 515 cells/mmc (mean); HIV-RNA <50 copies/ml in all patients; HCV-RNA 28, 3 × 106 copies/ml.
        
        
          Results
          At 48 weeks, 10 patients (20%) achieved a biochemical and virological response according to an intention to treat analysis.
          Twenty four patients (48%) underwent a drop-out mainly by side effects related to overlapping toxicity of interferon and antiretroviral therapy. All the patients, who responded to the treatment, showed a fast relapse one month after the end of treatment.
        
        
          Conclusion
          Although our results demonstrated a very poor outcome and a bad tolerance to interferon monotherapy, this approach should not be dropped out, mainly in patients at high risk for side effects and in those with cirrhosis who do not tolerate or are at increased risk for the use of ribavirin.

Tags: antiretroviral-therapy, hiv-hcv-coinfection, interferon-therapy, nih, treatment-outcomes
Organization: U.S. Department of Health & Human Services
Polarized Th2 like cells, in the absence of Th0 cells, are responsible for lymphocyte produced IL-4 in high IgE-producer schistosomiasis patients

Background
          Human resistance to re-infection with S. mansoni is correlated with high levels of anti-soluble adult worm antigens (SWAP) IgE. Although it has been shown that IL-4 and IL-5 are crucial in establishing IgE responses in vitro, the active in vivo production of these cytokines by T cells, and the degree of polarization of Th2 vs. Th0 in human schistosomiasis is not known. To address this question, we determined the frequency of IL-4 and IFN-γ or IL-5 and IL-2 producing lymphocytes from schistosomiasis patients with high or low levels of IgE anti-SWAP.
        
        
          Results
          Our analysis showed that high and low IgE-producers responded equally to schistosomiasis antigens as determined by proliferation. Moreover, patients from both groups displayed similar percentages of circulating lymphocytes. However, high IgE-producers had an increased percentage of activated CD4+ T cells as compared to the low IgE-producers. Moreover, intracellular cytokine analysis, after short-term stimulation with anti-CD3/CD28 mAbs, showed that IgE high-producers display an increase in the percentage of T lymphocytes expressing IL-4 and IL-5 as compared to IgE low-responders. A coordinate control of the frequency of IL-4 and IL-5 producing lymphocytes in IgE high, but not IgE low-responders, was observed.
        
        
          Conclusions
          High IgE phenotype human schistosomiasis patients exhibit a coordinate regulation of IL-4 and IL-5 producing cells and the lymphocyte derived IL-4 comes from true polarized Th2 like cells, in the absence of measurable Th0 cells as measured by co-production of IL-4 and IFN-γ.

Tags: ige-response, il-4-production, nih, schistosomiasis, th2-cells
Organization: U.S. Department of Health & Human Services
2018 Uniform Reporting System (URS) Table for Ohio

This is the 2018 Uniform Reporting System (URS) Output Tables for Ohio. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: mental-health-services, national-outcome-measures, ohio-mental-health, samhsa, substance-abuse-treatment
Organization: U.S. Department of Health & Human Services
Maryland (MD)

This report presents Maryland\'s estimates for 25 measures of substance use and mental health based on the combined 2009 and 2010 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for Maryland for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: maryland-health, mental-health, nsduh-data, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
New York City – 5 Boros: Drug-Related Emergency Department Visits, 2004-2011 - All Misuse and Abuse

Excel file with estimates, rates, relative standard errors, trends and confidence intervals for all drug-related emergency department (ED) visits involving drug misuse or abuse in New York City (5 boroughs), covering 2004-2011. Drug misuse/abuse visits include the use of illicit drugs, nonmedical use of pharmaceuticals, underage drinking and visits where alcohol was combined with another drug.

Tags: drug-related-ed-visits, nyc-emergency-departments, pharmaceutical-misuse, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
Compound 528520: Hexadecane, 5-hexyl

Chemical compound data from PubChem database. IUPAC Name: 7-butyloctadecane. Molecular Formula: C22H46. Molecular Weight: 310.6. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 528444: 1-Dodecene, 4-ethyl

Chemical compound data from PubChem database. IUPAC Name: 4-ethyldodec-1-ene. Molecular Formula: C14H28. Molecular Weight: 196.37. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services