AndreaBozzo/ceres-open-data-index huggingface dataset:
NSDUH: Alternative Statistical Models to Predict Mental Illness

The Mental Health Surveillance Study (MHSS) clinical follow-up was conducted as part of the National Survey on Drug Use and Health (NSDUH) from 2008 to 2012 for the primary purpose of developing models that estimate the prevalence of serious mental illness (SMI) and any mental illness (AMI) in the adult (18 or older) U.S. population (Center for Behavioral Health Statistics and Quality [CBHSQ], 2014). In each of these years, the MHSS clinical study consisted of a subsample of eligible adults selected from the main NSDUH study for follow-up clinical interviews. A prediction model was developed that included SMI status (collected in the clinical interview) as the dependent variable. The predictor variables were variables such as psychological distress and impairment measures that were collected in the main NSDUH questionnaire for adults. The resulting prediction model developed from the MHSS clinical data was then applied to all adult NSDUH respondents to obtain the predicted probability of SMI for each respondent.

Tags: mental-health-surveillance, nsduh-mhss, samhsa, serious-mental-illness, smi-prevalence
Organization: U.S. Department of Health & Human Services
Ohio AFCARS Assessment Review

This webpage includes the documentation from Ohio's Adoption and Foster Care Analysis and Reporting System (AFCARS) assessment review for fiscal year 2012:

AFCARS Assessment Review Findings - Letter (PDF) (PDF - 72 KB)

AFCARS Assessment Review Report - Ohio (PDF) (PDF - 172 KB)

Tab A - Detailed Findings (PDF) (PDF - 7 KB)

Findings Instructions (PDF) (PDF - 52 KB)

Section I - General Requirements (PDF) (PDF - 8 KB)

AFCARS Assessment Review Findings - General Requirement (PDF) (PDF - 232 KB)

Section II - Foster Care and Adoption Elements / Diagnosed Conditions Table (PDF) (PDF - 8 KB)

AFCARS Assessment Review Findings - Foster Care and Adoption Data Elements (PDF) (PDF - 491 KB)

Section III - Case File Review (PDF) (PDF - 7 KB)

AFCARS Case File Summary Report - Ohio (PDF) (PDF - 81 KB)

AFCARS Assessment Review Case File Findings - Foster Care and Adoption Data Elements (PDF) (PDF - 428 KB)

Tab B - AFCARS Improvement Plan (PDF) (PDF - 7 KB)

Improvement Plan Instructions (PDF) (PDF - 82 KB)

Section I - General Requirements (PDF) (PDF - 8 KB)

AFCARS Assessment Review Improvement Plan - General Requirements (PDF) (PDF - 194 KB)

Section II - Foster Care and Adoption Elements (PDF) (PDF - 8 KB)

AFCARS Assessment Review Improvement Plan - Foster Care and Adoption Data Elements (PDF) (PDF - 587 KB)

AFCARS Close-out Letter (PDF) (PDF - 80 KB)

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: adoption, assessment, fiscal, foster, reporting
Organization: U.S. Department of Health & Human Services
Compound 527239: Tetrahydrofuran, 3-isopropyl-2-(3-methylcyclopent-2-enyl)

Chemical compound data from PubChem database. IUPAC Name: 2-(5-methylcyclopenten-1-yl)-3-propan-2-yloxolane. Molecular Formula: C13H22O. Molecular Weight: 194.31. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
NSDUH 2021 Person Level Sampling Weight Report

Learn about the techniques used to create weights for the 2021 National Survey on Drug Use and Health (NSDUH) at the person level. The report reviews the generalized exponential model (GEM) used in weighting, discusses potential predictor variables, and details the practical steps used to implement GEM. The report also details the weight calibrations, and presents the evaluation measures of the calibrations, as well as a sensitivity analysis.Chapters:Introduces the survey and the remainder of the report.Reviews the impact of multimode data collection on weighting.Briefly describes of the generalized exponential model.Describes the predictor variables for the model calibration.Defines extreme weights.Discusses control totals for poststratification adjustments.Discusses weight calibration at the dwelling unit level.Discusses weight calibration at the person level.Presents the evaluation measures of calibrated weights and a sensitivity analysis of selected prevalence estimates.Explains the break-off analysis weights.Explains the alternative analysis weights.Appendices include technical details about the model and the evaluations that were performed.

Tags: samhsa, sampling-weights, statistical-analysis, substance-use, survey-methodology
Organization: U.S. Department of Health & Human Services
T cells that are naturally tolerant to cartilage-derived type II collagen are involved in the development of collagen-induced arthritis

The immunodominant T-cell epitope that is involved in collagen-induced arthritis (CIA) is the glycosylated type II collagen (CII) peptide 256-270. In CII transgenic mice, which express the immunodominant CII 256-270 epitope in cartilage, the CII-specific T cells are characterized by a partially tolerant state with low proliferative activity in vitro, but with maintained effector functions, such as IFN-γ secretion and ability to provide B cell help. These mice were still susceptible to CIA. The response was mainly directed to the glycosylated form of the CII 256-270 peptide, rather than to the nonglycosylated peptide. Tolerance induction was rapid; transferred T cells encountered CII within a few days. CII immunization several weeks after thymectomy of the mice did not change their susceptibility to arthritis or the induction of partial T-cell tolerance, excluding a role for recent thymic emigrants. Thus, partially tolerant CII autoreactive T cells are maintained and are crucial for the development of CIA.

Tags: autoimmune-response, cii-transgenic-mice, collagen-induced-arthritis, nih, t-cell-tolerance
Organization: U.S. Department of Health & Human Services
Stroke in urban and rural populations in north-east Bulgaria: incidence and case fatality findings from a 'hot pursuit' study

Background
          Bulgaria's official stroke mortality rates are higher for rural than urban areas. Official mortality data has indicated that these rates are amongst the highest in Europe. There has been a lack of studies measuring stroke incidence in urban and rural populations.
        
        
          Methods
          We established intensive notification networks covering 37791 residents in Varna city and 18656 residents (55% of them village-dwellers), all aged 45 to 84, in 2 rural districts. From May 1, 2000 to April 30, 2001 frequent contact was maintained with notifiers and death registrations were scanned regularly. Suspected incident strokes were assessed by study neurologists within a median of 8 days from onset.
        
        
          Results
          742 events were referred for neurological assessment and 351 of these, which met the WHO criteria for stroke, were in persons aged 45 to 84 and were first ever in a lifetime. Incidence rates, standardised using the world standard weights for ages 45 to 84, were 909 (/100000/year) (95% CI 712–1105) and 597 (482–712) for rural and urban males and 667 (515–818) and 322 (248–395) for rural and urban females. Less than half were admitted to hospital (15% among rural females over 65). Twenty-eight day case fatality was 35% (123/351) overall and 48% (46/96) in village residents. The excess case fatality in the villages could not be explained by age or severity.
        
        
          Conclusions
          Rural incidence rates were over twice those reported for western populations but the rate for urban females was similar to other western rates. The high level and marked heterogeneity in both stroke incidence and case fatality merit further investigation.

Tags: bulgaria, case-fatality, nih, rural-urban-health, stroke-incidence
Organization: U.S. Department of Health & Human Services
Results from the 2013 National Survey on Drug Use and Health: Summary of National Findings and Detailed Tables

This report and the detailed tables present a first look at results from the 2013 National Survey on Drug Use and Health (NSDUH), an annual survey of the civilian, noninstitutionalized population of the United States aged 12 years old or older. Both the report and detailed tables present national estimates of rates of use, numbers of users, and other measures related to illicit drugs, alcohol, and tobacco products, with a focus on trends between 2012 and 2013 and from 2002 to 2013, as well as differences across population subgroups in 2013. NSDUH national estimates related to mental health and NSDUH State-level estimates related to both substance use and mental health will be published in separate releases in the fall of 2014.

Tags: alcohol-consumption, drug-use, national-survey, samhsa, tobacco-use
Organization: U.S. Department of Health & Human Services
2022 Uniform Reporting System (URS) Table For Nebraska

This is the 2022 Uniform Reporting System (URS) Output Tables for Nebraska. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant, mental-health-services, nebraska, outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
2016 Uniform Reporting System (URS) Table for Alaska

This is the 2016 Uniform Reporting System (URS) Output Tables for Alaska. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: alaska, block-grant, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Molecular cloning and sequence analysis of hamster CENP-A cDNA

Background
          The centromere is a specialized locus that mediates chromosome movement during mitosis and meiosis. This chromosomal domain comprises a uniquely packaged form of heterochromatin that acts as a nucleus for the assembly of the kinetochore a trilaminar proteinaceous structure on the surface of each chromatid at the primary constriction. Kinetochores mediate interactions with the spindle fibers of the mitotic apparatus. Centromere protein A (CENP-A) is a histone H3-like protein specifically located to the inner plate of kinetochore at active centromeres. CENP-A works as a component of specialized nucleosomes at centromeres bound to arrays of repeat satellite DNA.
        
        
          Results
          We have cloned the hamster homologue of human and mouse CENP-A. The cDNA isolated was found to contain an open reading frame encoding a polypeptide consisting of 129 amino acid residues with a C-terminal histone fold domain highly homologous to those of CENP-A and H3 sequences previously released. However, significant sequence divergence was found at the N-terminal region of hamster CENP-A that is five and eleven residues shorter than those of mouse and human respectively. Further, a human serine 7 residue, a target site for Aurora B kinase phosphorylation involved in the mechanism of cytokinesis, was not found in the hamster protein. A human autoepitope at the N-terminal region of CENP-A described in autoinmune diseases is not conserved in the hamster protein.
        
        
          Conclusions
          We have cloned the hamster cDNA for the centromeric protein CENP-A. Significant differences on protein sequence were found at the N-terminal tail of hamster CENP-A in comparison with that of human and mouse. Our results show a high degree of evolutionary divergence of kinetochore CENP-A proteins in mammals. This is related to the high diverse nucleotide repeat sequences found at the centromere DNA among species and support a current centromere model for kinetochore function and structural plasticity.

Tags: cenp-a, centromere-protein, hamster-cdna, molecular-cloning, nih
Organization: U.S. Department of Health & Human Services
Table 9. Alcohol Use in the Past Month among Persons Aged 12 or Older, by State and Substate Regions: Percentages, Annual Averages Based on 2008, 2009, and 2010 NSDUHs

This table presents the 2008 to 2010 National Survey on Drug Use and Health (NSDUH) estimates of past month alcohol use by those aged 12 or older by State and substate regions.

Tags: adolescent-alcohol, alcohol-use, nsduh, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Region 10, Volume 7

Explore state and regional data for HHS Region 10 with this user-friendly behavioral health report. It uses data from the 2021-2022 National Surveys on Drug Use and Health (NSDUH). The topics addressed in this report include substance use, substance use disorders, and mental health. Selected estimates are provided for adolescents aged 12 to 17, underage people aged 12 to 20, adults aged 18 or older, and the general population aged 12 or older. Statistical tests compare population percentages of (1) HHS region versus national estimates, (2) state versus national estimates, and (3) state versus HHS region estimates.

Tags: behavioral-health, mental-health, nsduh-data, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Growth factors in lung development and disease: friends or foe?

Growth factors mediate tissue interactions and regulate a variety of cellular functions that are critical for normal lung development and homeostasis. Besides their involvement in lung pattern formation, growth and cell differentiation during organogenesis, these factors have been also implicated in modulating injury-repair responses of the adult lung. Altered expression of growth factors, such as transforming growth factor β1, vascular endothelial growth factor and epidermal growth factor, and/or their receptors, has been found in a number of pathological lung conditions. In this paper, we discuss the dual role of these molecules in mediating beneficial feedback responses or responses that can further damage lung integrity; we shall also discuss the basis for their prospective use as therapeutic agents.

Tags: growth-factors, lung-development, lung-injury-repair, nih, pulmonary-disease
Organization: U.S. Department of Health & Human Services
South Dakota 2016 Potential Areas for Addressing Service Gaps for Opioid Treatment

The purpose of the medication-assisted treatment (MAT) facility maps is to identify areas on a state-by-state basis that may be potentially underserved by existing treatment facilities. The maps are created with a methodology that seeks to include the highest potential need areas from individual counties so that county-level stakeholders are also informed. The maps are meant to be used as a tool for policy makers to determine potentially underserved areas—not as a definitive representation of these areas.

Tags: medication-assisted-treatment, opioid-treatment, samhsa, service-gap-analysis, south-dakota
Organization: U.S. Department of Health & Human Services
2011 State Profile — New Hampshire

This is a National Survey of Substance Abuse Treatment Services (N-SSATS) data table showing state profiles for New Hampshire in 2011. N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 States, the District of Columbia, and other U.S. jurisdictions.

Tags: n-ssats, new-hampshire, samhsa, substance-abuse-treatment, treatment-facilities
Organization: U.S. Department of Health & Human Services
Compound 525168: Hexapropylene glycol, diacetate

Chemical compound data from PubChem database. IUPAC Name: 2-[2-[2-[2-[2-(2-acetyloxypropoxy)propoxy]propoxy]propoxy]propoxy]propyl acetate. Molecular Formula: C22H42O9. Molecular Weight: 450.6. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Trends in Nonmedical Use of Prescription Pain Relievers: 2002 to 2007

This report uses NSDUH data from 2002 to 2007 on Prescription Pain Relievers.  In 2007, 2.1 percent of persons aged 12 or older (an estimated 5.2 million persons) reported using prescription pain relievers nonmedically in the past month; this rate does not differ significantly from that in 2002.

Tags: nonmedical-use, nsduh-data, prescription-painkillers, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
Compound 525353: 2,2-Dimethyl-4,5-dithiaheptane

Chemical compound data from PubChem database. IUPAC Name: 1-(ethyldisulfanyl)-2,2-dimethylpropane. Molecular Formula: C7H16S2. Molecular Weight: 164.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2013 CMHS Uniform Reporting System (URS) Table for South Carolina

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Tables for South Carolina for 2013. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program.  State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: mental-health-services, outcome-measures, samhsa, south-carolina, utilization-measures
Organization: U.S. Department of Health & Human Services
4.10 Clinical/therapeutic approaches, by frequency of use: 2011. Number and percent distribution

This is a National Survey of Substance Abuse Treatment Services (N-SSATS) data table showing clinical/therapeutic approaches, by frequency of use in 2011. N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 States, the District of Columbia, and other U.S. jurisdictions.

Tags: behavioral-therapy, n-ssats, samhsa, substance-abuse-treatment, therapeutic-approaches
Organization: U.S. Department of Health & Human Services
Compound 528570: tert-Butyl(dimethyl)silyl 4-([tert-butyl(dimethyl)silyl]oxy)benzoate

Chemical compound data from PubChem database. IUPAC Name: [tert-butyl(dimethyl)silyl] 4-[tert-butyl(dimethyl)silyl]oxybenzoate. Molecular Formula: C19H34O3Si2. Molecular Weight: 366.6. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Chicago: Drug-Related Emergency Department Visits, 2004-2011 - Accidental Ingestions

Excel file with estimates, rates, relative standard errors, trends and confidence intervals, covering 2004-2011 for emergency department visits involving accidental ingestions in the Chicago metropolitan area. This analytic category includes ED visits in which an individual accidentally or unknowingly used or was administered a prescription drug, over-the-counter medication, or dietary supplement. Drug-related accidental ingestion typically involves patients aged 5 and under.  This analytic category does not include drug misuse or abuse.File includes data for over 500 drugs, including illicit drugs, prescription and over-the-counter medications, dietary supplements, inhalants and alcohol.  Includes total visits, gender, age group, race/ethnicity, outcome of visit, drug combinations, number of drugs involved in visit, drug frequency, and drugs confirmed by toxicology.Additional detail is provided for illicit drugs, psychotherapeutic drugs, central nervous system (CNS) drugs, respiratory drugs and cardiovascular drugs.

Tags: accidental-ingestion, drug-related-visits, emergency-department, pediatric-poisoning, samhsa
Organization: U.S. Department of Health & Human Services
Fibroblast biology: Effector signals released by the synovial fibroblast in arthritis

There is mounting evidence indicating that the synovial fibroblast is a direct effector of tissue injury and matrix remodeling in inflammatory synovitis. Through the elaboration of effector signals including cytokines and chemokines, mesenchymal cells stimulate or suppress inflammation via autocrine and paracrine mechanisms. Synovial fibroblasts are the principal cells mediating joint destruction through secretion of metalloproteinases, and recent evidence suggests that they may also promote bone resorption by stimulating osteoclastogenesis. Moreover, they may play an integral role in the initial phases of synovitis by releasing chemokines that recruit leukocytes to the joint, and cytokines that trigger angiogenesis. Studies focusing on synoviocyte-leukocyte interactions mediated via the cytokine network and the role of cell-cell contact in driving synoviocyte activation will help define the complex interplay that leads to the initiation and perpetuation of synovial inflammation.

Tags: cytokine-signaling, nih, rheumatoid-arthritis, synovial-fibroblasts, synovitis
Organization: U.S. Department of Health & Human Services
Compound 528366: (R,S)-N-Nitroso Anatabine

Chemical compound data from PubChem database. IUPAC Name: 3-(1-nitroso-3,6-dihydro-2H-pyridin-2-yl)pyridine. Molecular Formula: C10H11N3O. Molecular Weight: 189.21. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2010 CMHS Uniform Reporting System (URS) Output Tables for Republic of Palau

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2010. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, national-outcome-measures, palau, samhsa
Organization: U.S. Department of Health & Human Services