AndreaBozzo/ceres-open-data-index huggingface dataset:
Kinetic comparison of tissue non-specific and placental human alkaline phosphatases expressed in baculovirus infected cells: application to screening for Down's syndrome

Background
          In humans, there are four alkaline phosphatases, and each form exibits a characteristic pattern of tissue distribution. The availability of an easy method to reveal their activity has resulted in large amount of data reporting correlations between variations in activity and illnesses. For example, alkaline phosphatase from neutrophils of mothers pregnent with a trisomy 21 fetus (Down's syndrome) displays significant differences both in its biochemical and immunological properties,  and in its affinity for some specific inhibitors.
        
        
          Results
          To analyse these differences, the biochemical characteristics of two isozymes (non specific and placental alkaline phosphatases) were expressed in baculovirus infected cells. Comparative analysis of the two proteins allowed us to estimate the kinetic constants of denaturation and sensitivity to two inhibitors (L-p-bromotetramisole and thiophosphate), allowing better discrimination between the two enzymes. These parameters were then used to estimate the ratio of the two isoenzymes in neutrophils of pregnant mothers with or without a trisomy 21 fetus. It appeared that the placental isozyme represented 13% of the total activity of neutrophils of non pregnant women. This proportion did not significantly increase with normal pregnancy. By contrast, in pregnancies with trisomy 21 fetus, the proportion reached 60–80% of activity.
        
        
          Conclusion
          Over-expression of the placental isozyme compared with the tissue-nonspecific form in neutrophils of mother with a trisomy 21 fetus may explain why the characteristics of the alkaline phosphatase in these cells is different from normal. Application of this knowledge could improve the potential of using alkaline phosphatase measurements to screen for Down's syndrome.

Tags: alkaline-phosphatase, down-syndrome-screening, enzyme-kinetics, nih, placental-alkaline-phosphatase
Organization: U.S. Department of Health & Human Services
Research Article: Arthritis Research

Wegener's granulomatosis (WG) is a form of systemic vasculitis. It is characterized by granulomatous inflammation in the upper and lower airways, vasculitis and necrotizing glomerulonephritis, and is strongly associated with antineutrophil cytoplasmic antibodies against proteinase 3. Since the etiology of the disease is not clear, treatment, consisting of corticosteroids and immunosuppressives, is nonspecific and associated with severe side effects. Pinpointing the trigger(s) of the disease would highly improve treatment. Clinical evidence shows that an infectious agent, the bacterium Staphylococcus aureus, is a risk factor for disease relapse, suggesting its involvement in the pathogenesis of WG. Here we review both clinical and experimental data that either indicate or support a role for S. aureus in WG.

Tags: antineutrophil-antibodies, nih, staphylococcus-aureus, systemic-vasculitis, wegeners-granulomatosis
Organization: U.S. Department of Health & Human Services
Compound 528343: Benzoic acid, 3-chloro-2-hydroxy, TMS

Chemical compound data from PubChem database. IUPAC Name: trimethylsilyl 3-chloro-2-trimethylsilyloxybenzoate. Molecular Formula: C13H21ClO3Si2. Molecular Weight: 316.92. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Comparative mutational analysis
 of

Human immunodeficiency virus type 1 (HIV-1) and human T cell
 leukemia virus type II (HTLV-2) use a similar mechanism for –1
 translational frameshifting to overcome the termination codon in
 viral RNA at the end of the gag gene. Previous
 studies have identified two important RNA signals for frameshifting,
 the slippery sequence and a downstream stem–loop structure.
 However, there have been somewhat conflicting reports concerning
 the individual contributions of these sequences. In this study we
 have performed a comprehensive mutational analysis of the cis-acting
 RNA sequences involved in HIV-1 gag–pol and HTLV-2 gag–pro frameshifting. Using an in vitro translation
 system we determined frameshifting efficiencies for shuffled HIV-1/HTLV-2
 RNA elements in a background of HIV-1 or HTLV-2 sequences. We show
 that the ability of the slippery sequence and stem–loop
 to promote ribosomal frameshifting is influenced by the flanking
 upstream sequence and the nucleotides in the spacer element. A wide
 range of frameshift efficiency rates was observed for both viruses
 when shuffling single sequence elements. The results for HIV-1/HTLV-2
 chimeric constructs represent strong evidence supporting the notion
 that the viral wild-type sequences are not designed for maximal
 frameshifting activity but are optimized to a level suited to efficient
 viral replication.

Tags: frameshifting-efficiency, hiv-1, htlv-2, mutational-analysis, nih
Organization: U.S. Department of Health & Human Services
Compound 525283: Ethanimidamide, N,N-dimethyl-N'-pentyl-

Chemical compound data from PubChem database. IUPAC Name: N,N-dimethyl-N'-pentylethanimidamide. Molecular Formula: C9H20N2. Molecular Weight: 156.27. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2021-2022 NSDUH: Guide to State Tables and Summary of Small Area Estimation Methodology

Use this guide to help interpret the 2021-2022 state-level estimates from the National Surveys on Drug Use and Health (NSDUH). It includes a summary of the small area estimation (SAE) methodology, as well as sample sizes, response rates, and population estimates for 35 measures of substance use and mental health.

Tags: mental-health, samhsa, small-area-estimation, state-level-data, substance-use
Organization: U.S. Department of Health & Human Services
The measurement of lung water

Introduction:
          In this review, we compare the spectrum of currently available				methods for quantifying pulmonary edema in patients.
        
        
          Review:
          Imaging and indicator dilution techniques comprise the most common				strategies for measuring lung water at the bedside. The most accurate (within				10% of the gravimetric gold standard) and most reproducible (< 5%				between-test variation) are also, unfortunately, the most expensive and most				difficult to implement for purposes of large-scale clinical trials or for				routine clinical practice.
        
        
          Conclusion:
          The standard chest radiograph remains the best screening test for				the detection of pulmonary edema. Indicator-dilution techniques are probably				the best available method at present for quantitation in patient groups.

Tags: imaging-techniques, indicator-dilution, lung-water, nih, pulmonary-edema
Organization: U.S. Department of Health & Human Services
A model combining cell physiology and population genetics to explain

Background
          Laboratory experiments under controlled conditions during thousands of generations are useful tools to assess the processes underlying bacterial evolution. As a result of these experiments, the way in which the traits change in time is obtained. Under these conditions, the bacteria E. coli shows a parallel increase in cell volume and fitness.
        
        
          Results
          To explain this pattern it is required to consider organismic and population contributions. For this purpose we incorporate relevant information concerning bacterial structure, composition and transformations in a minimal modular model. In the short time scale, the model reproduces the physiological responses of the traits to changes in nutrient concentration. The decay of unused catabolic functions, found experimentally, is introduced in the model using simple population genetics. The resulting curves representing the evolution of volume and fitness in time are in good agreement with those obtained experimentally.
        
        
          Conclusions
          This study draws attention on physiology when studying evolution. Moreover, minimal modular models appear to be an adequate strategy to unite these barely related disciplines of biology.

Tags: bacterial-adaptation, cell-physiology, e-coli-evolution, nih, population-genetics
Organization: U.S. Department of Health & Human Services
3.3 Clients in treatment, by substance abuse problem and diagnosed co-occurring substance abuse and mental disorders: 2007-2011. Number and percent distribution

This a National Survey of Substance Abuse Treatment Services (N-SSATS) data table showing clients in treatment, by substance abuse problem and diagnosed co-occurring substance abuse and mental disorders from 2007 to 2011.

Tags: co-occurring-disorders, mental-health, samhsa, substance-abuse, treatment-services
Organization: U.S. Department of Health & Human Services
2014-2016 NSDUH Substate Region Shapefile

This report provides a guide to the development and presentation of 2014-2016 NSDUH substate estimates. A summary of the estimation methodology is included as well as sample sizes, response rates, and population estimates. This shapefile includes geographic boundaries of the 2014-2016 NSDUH substate regions along with prevalence rates, map group values, and the upper and lower bounds found in the map legends. It can be used for analysis and data display with Geographic Information Systems (GIS) software.

Tags: gis-shapefile, mental-health, prevalence-rates, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
The Federal Parent Locator Service

The Federal Parent Locator Service (FPLS), a service operated by the Office of Child Support Services (OCSS), may be accessed by state child welfare agencies to locate and notify parents and other relatives of a child placed in foster care. The FPLS may also be used to locate youth who have exited foster care to provide services or for purposes of completing the National Youth in Transition Database (NYTD) survey. CB and OCSE jointly published an Information Memorandum (ACYF-CB-IM-12-06) that discusses the FPLS, child support information available to state child welfare agencies, and related topics.

State child welfare agencies may request FPLS information several ways including:

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: care, child, data, foster, policy
Organization: U.S. Department of Health & Human Services
Compound 527309: Diflunisal di-methyl derivative

Chemical compound data from PubChem database. IUPAC Name: methyl 5-(2,4-difluorophenyl)-2-methoxybenzoate. Molecular Formula: C15H12F2O3. Molecular Weight: 278.25. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Colonic tuberculosis mimicking Crohn's disease: case report

Background
          Intestinal tuberculosis is a rare disease in western countries, affecting mainly immigrants and immunocompromised patients. Intestinal tuberculosis is a diagnostic challenge, especially when active pulmonary infection is absent. It may mimic many other abdominal diseases.
        
        
          Case presentation
          Here, we report a case of isolated colonic tuberculosis where the initial diagnostic workup was suggestive of Crohn's disease. Computed tomography findings however, raised the possibility of colonic tuberculosis and the detection of acid-fast bacilli in biopsy specimens confirmed the diagnosis.
        
        
          Conclusions
          In conclusion, this case highlights the need for awareness of intestinal tuberculosis in the differential diagnosis of chronic intestinal disease

Tags: case-report, colonic-tuberculosis, crohns-disease, intestinal-tuberculosis, nih
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Massachusetts, 2014

This is a behavioral health report for the state of Massachusetts. It uses the National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment Services (NSSATS) to address the topics of youth substance use, youth mental health and treatment, adult mental health and treatment, substance use, and substance use treatment for the years 2009 to 2013.

Tags: behavioral-health, massachusetts, mental-health, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
2013 CMHS Uniform Reporting System (URS) Tables for Iowa

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Tables for Iowa for 2013. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program.  State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant, iowa, mental-health-services, noms, samhsa
Organization: U.S. Department of Health & Human Services
Pittsburgh, PA

This report presents combined 2005 to 2010 National Survey on Drug Use and Health (NSDUH) results for those aged 12 or older in the Pittsburgh, PA metro area. The report includes estimates of substance use disorder, major depressive episode, illicit drug use, marijuana use, cigarette use, binge alcohol use, and the nonmedical use of prescription-type pain relievers. Results are provided for the Pittsburgh metro area, Pennsylvania, and the U.S. overall.

Tags: major-depression, nsduh-data, pittsburgh-metro, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
NSDUH 2010 Methodological Resource Book (MRB)

This Methodological Resource Book (MRB) is intended to serve as documentation of survey materials and methodology associated with the 2010 National Survey on Drug Use and Health (NSDUH). The MRB includes details associated with data collection and processing, including sampling, instrument testing and development, weighting, imputation, and statistical analyses and inferences.

Tags: data-collection, samhsa, statistical-analysis, substance-use, survey-methodology
Organization: U.S. Department of Health & Human Services
Publications Using SAMHSA Data2021 Uniform Reporting System (URS) Table For Louisiana

This is the 2021 Uniform Reporting System (URS) Output Tables for Louisiana. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: mental-health-services, national-outcome-measures, samhsa, substance-abuse-treatment, urs-data
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Kansas, 2014

This is a behavioral health report for the state of Kansas. It uses the National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment Services (NSSATS) to address the topics of youth substance use, youth mental health and treatment, adult mental health and treatment, substance use, and substance use treatment for the years 2009 to 2013.

Tags: kansas-behavioral-health, mental-health-indicators, samhsa, substance-use-trends, youth-mental-health
Organization: U.S. Department of Health & Human Services
2017 Uniform Reporting System (URS) Table for Tennessee

This is the 2017 Uniform Reporting System (URS) Output Tables for Tennessee. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, evidence-based-practices, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Compound 525267: N'-(3-chloro-phenyl)-N,N-dimethyl-acetamidine

Chemical compound data from PubChem database. IUPAC Name: N'-(3-chlorophenyl)-N,N-dimethylethanimidamide. Molecular Formula: C10H13ClN2. Molecular Weight: 196.67. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2013 NSDUH Statistical Inference Report

The focus of this report is to describe the statistical inference procedures used to produce design-based estimates as presented in the 2013 detailed tables, the 2013 mental health detailed tables, the 2013 national findings report, and the 2013 mental health findings report. Thestatistical procedures and information found in this report can also be generally applied to analyses based on the public use file as well as the restricted-use file available through the data portal. This report is organized as follows: Section 2 provides background informationconcerning the 2013 NSDUH; Section 3 discusses the prevalence rates and how they were calculated, including specifics on topics such as mental illness, major depressive episode, and serious psychological distress; Section 4 briefly discusses how missing item responses of variables that are not imputed may lead to biased estimates; Section 5 discusses sampling errors and how they were calculated; Section 6 describes the degrees of freedom that were used when comparing estimates; and Section 7 discusses how the statistical significance of differences between estimates was determined. Section 8 discusses confidence interval estimation, and Section 9 describes how past year incidence of drug use was computed. Finally, Section 10 discusses the conditions under which estimates with low precision were suppressed. Appendix A contains examples that demonstrate how to conduct various statistical procedures documented within this report using SAS® and SUDAAN® Software for Statistical Analysis of Correlated Data (RTI International, 2012) along with separate examples using Stata® software.

Tags: mental-health-statistics, nsduh-methodology, prevalence-rates, samhsa, statistical-inference
Organization: U.S. Department of Health & Human Services
Oregon (OR)

This report uses 2008 to 2010 National Survey on Drug Use and Health (NSDUH) to assess past year alcohol use disorder and illicit drug use disorder among persons aged 12 or older for Oregon overall and for substate regions within Oregon. Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE).

Tags: alcohol-drug-abuse, mental-health-oregon, nsduh-data, samhsa, substance-use-disorder
Organization: U.S. Department of Health & Human Services
Compound 525237: N''-(3-bromo-phenyl)-N,N,N',N'-tetramethyl-guanidine

Chemical compound data from PubChem database. IUPAC Name: 2-(3-bromophenyl)-1,1,3,3-tetramethylguanidine. Molecular Formula: C11H16BrN3. Molecular Weight: 270.17. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Table 12. Alcohol Use in the Past Month among Persons Aged 12 to 20, by State and Substate Regions: Percentages, Annual Averages Based on 2008, 2009, and 2010 NSDUHs

This table presents the 2008 to 2010 National Survey on Drug Use and Health (NSDUH) estimates of past month alcohol use by those aged 12 to 20 in State and substate regions.

Tags: adolescent-alcohol-use, nsduh-data, samhsa, substance-use-survey, youth-alcohol-consumption
Organization: U.S. Department of Health & Human Services
Transcriptional regulation of lung development: emergence of specificity

The lung is the product of a set of complex developmental interactions between two distinct tissues, the endodermally derived epithelium and the mesoderm. Each tissue contributes to lung development by fine-tuning the spatial and temporal pattern of gene expression for a distinct array of signaling molecules, transcriptional molecules and molecules related to the extracellular matrix. Morphoregulatory transcriptional factors such as NKX2.1 have the crucial role of connecting the cell–cell crosstalk to the activation or repression of gene expression through which processes such as cellular proliferation, migration, differentiation and apoptosis can be controlled. Although none of the factors participating in lung development are exclusively lung-specific, their unique combinations and interactions constitute the basis for emergence of lung structural and functional specificities. An understanding of the individual molecules and their unique interactions in the context of lung development is necessary for the construction of a morphogenetic map for this vital organ as well as for the development of rational and innovative approaches to congenital and induced lung disease.

Tags: lung-development, lung-morphogenesis, nih, nkx21, transcriptional-regulation
Organization: U.S. Department of Health & Human Services