AndreaBozzo/ceres-open-data-index huggingface dataset:
2022-2023 NSDUH: State Estimates of Substance Use and Mental Health

Find state-level estimates for 38 measures of substance use and mental health from the 2022-2023 National Surveys on Drug Use and Health (NSDUH). These estimates are based on small area estimation (SAE) methods in which state-level NSDUH data are combined with other data from smaller geographies. The combined data are used to create modeled state estimates of the civilian, noninstitutionalized population ages 12 and older, both overall and by age group.Along with the estimates, the collection includes: tables that allow statistical comparisons between estimates (across time and geography), an overview of the estimation methodology, and a review of other state-level substance use and mental health data sources.The data are available as tables by measure or by state in a variety of file formats.

Tags: mental-health, samhsa, small-area-estimation, state-estimates, substance-use
Organization: U.S. Department of Health & Human Services
A comparison of hospital readmission rates between two general physicians with different outpatient review practices

Background
          There has been a relentless increase in emergency medical admissions in the UK over recent years. Many of these patients suffer with chronic conditions requiring continuing medical attention. We wished to determine whether conventional outpatient clinic follow up after discharge has any impact on the rate of readmission to hospital.
        
        
          Methods
          Two consultant general physicians with the same patient case-mix but markedly different outpatient follow-up practice were chosen. Of 1203 patients discharged, one consultant saw twice as many patients in the follow-up clinic than the other (Dr A 9.8% v Dr B 19.6%). The readmission rate in the twelve months following discharge was compared in a retrospective analysis of hospital activity data. Due to the specialisation of the admitting system, patients mainly had cardiovascular or cerebrovascular disease or had taken an overdose. Few had respiratory or infectious diseases. Outpatient follow-up was focussed on patients with cardiac disease.
        
        
          Results
          Risk of readmission increased significantly with age and length of stay of the original episode and was less for digestive system and musculo-skeletal disorders. 28.7% of patients discharged by Dr A and 31.5 % of those discharged by Dr B were readmitted at least once. Relative readmission risk was not significantly different between the consultants and there was no difference in the length of stay of readmissions.
        
        
          Conclusions
          Increasing the proportion of patients with this age- and case-mix who are followed up in a hospital general medical outpatient clinic is unlikely to reduce the demand for acute hospital beds.

Tags: cardiovascular-disease, cerebrovascular-disease, hospital-readmission, nih, outpatient-follow-up
Organization: U.S. Department of Health & Human Services
Child Welfare Then and Now

This Child Welfare Information Gateway Podcast is available on Apple Podcasts
  
  

, GooglePlay
  
  

, Spotify
  
  

, Stitcher
  
  

, SoundCloud
  
  

, and the Child Welfare Information Gateway
  
  

 website. Subscribe to receive new episodes as they are released.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: child, policy, public, sery, social
Organization: U.S. Department of Health & Human Services
Massachusetts 2016 Potential Areas for Addressing Service Gaps for Opioid Treatment

The purpose of the medication-assisted treatment (MAT) facility maps is to identify areas on a state-by-state basis that may be potentially underserved by existing treatment facilities. The maps are created with a methodology that seeks to include the highest potential need areas from individual counties so that county-level stakeholders are also informed. The maps are meant to be used as a tool for policy makers to determine potentially underserved areas—not as a definitive representation of these areas.

Tags: massachusetts, mat-access, opioid-treatment, samhsa, service-gaps
Organization: U.S. Department of Health & Human Services
2021 Methodological Summary And Definitions

Use this summary report to properly interpret 2021 NSDUH estimates of substance use and mental health issues. The report accompanies theannual detailed tablesand covers overall methodology, key definitions for measures and terms used in 2021 NSDUH reports and tables, and selected analyses of the measures and how they should be interpreted.The report is organized into six chapters:Introduction.Description of the survey, including information about the sample design, data collection procedures, and key aspects of data processing such as development of the analysis weights. The report also includes methodological changes and related issues in the 2021 NSDUH due to COVID-19.Technical details on the statistical methods and measurement, such as suppression criteria for unreliable estimates, statistical testing procedures, issues around selected substance use and mental health measures, and the impact of methodological changes on response rates.Special topics related to prescription psychotherapeutic drugs.A comparison between NSDUH and other sources of data on substance use and mental health issues, including data sources for populations outside the NSDUH target population.A more in-depth view of special methodological issues for the 2021 NSDUH, including the results of special analyses that led SAMHSA to not compare estimates from 2021 to estimates from previous years.An appendix covers key definitions used in NSDUH reports and tables.

Tags: mental-health, nsduh-methodology, samhsa, substance-use, survey-definitions
Organization: U.S. Department of Health & Human Services
2015 CMHS Uniform Reporting System (URS) Table for Connecticut

2015 Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for Connecticut. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, connecticut-mental-health, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
The dominance of the population by a selected few: power-law behaviour applies to a wide variety of genomic properties

The sequencing of genomes provides us with an inventory of the 'molecular parts' in nature, such as protein families and folds, and their functions in living organisms. The genomic occurrence of generalized parts follows a well-known mathematical framework called the power law, with a few parts occurring many times and most occurring only a few times. Cases of power-law behavior, were found, for example in the occurrence of pseudogenes and in levels of gene expression.

Tags: gene-expression, genomic-properties, nih, power-law-distribution, pseudogenes
Organization: U.S. Department of Health & Human Services
Compound 525692: p-Chlorobenzylidene-propyl-amine

Chemical compound data from PubChem database. IUPAC Name: 1-(4-chlorophenyl)-N-propylmethanimine. Molecular Formula: C10H12ClN. Molecular Weight: 181.66. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
AFCARS Report #29

This report provides preliminary estimates of Adoption and Foster Care Analysis and Reporting System (AFCARS) data for FY 2021. As states are permitted to resubmit AFCARS data, the estimates may change over time. This report reflects all AFCARS data received as of June 28, 2022 related to AFCARS reporting periods through September 30, 2021.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: adoption, data, foster, policy, reporting
Organization: U.S. Department of Health & Human Services
Compound 525185: Tetrapropylene glycol, monoallyl ether, acetate

Chemical compound data from PubChem database. IUPAC Name: 1-[1-[1-(1-prop-2-enoxypropan-2-yloxy)propan-2-yloxy]propan-2-yloxy]propan-2-yl acetate. Molecular Formula: C17H32O6. Molecular Weight: 332.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2021 Uniform Reporting System (URS) Table For Maryland

This is the 2021 Uniform Reporting System (URS) Output Tables for Maryland. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-data, mental-health-services, national-outcome-measures, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
2019 Uniform Reporting System (URS) Table for Vermont

These are the 2019 Uniform Reporting System (URS) Output Tables for Vermont. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-program, mental-health-services, national-outcome-measures, samhsa, vermont-mental-health
Organization: U.S. Department of Health & Human Services
NSDUH 2022 Sample Design Report

Learn about the sample design used for the 2022 National Survey on Drug Use and Health (NSDUH). The report describes the five stages of sample selection, sample weighting and variance estimation procedures, and the impact of the coronavirus disease 2019 (COVID-19) pandemic on sampling.Chapters:Introduces the report, describes the target population, provides a general overview of the 2022 NSDUH sample design, and summarizes the impact of the COVID-19 pandemic on the 2022 NSDUH.Summarizes the 2014 through 2022 coordinated sample design.Discusses the first three stages of selection in greater detail.Describes the 2022 NSDUH hybrid field enumeration and address-based sampling frameDiscusses the fourth and fifth stages of selection.Describes sample weighting and variance estimation procedures for 2022.Summarizes the sample design for the Incentives Field Test

Tags: nsduh-sample-design, samhsa, sampling-methodology, substance-use-survey, survey-weighting
Organization: U.S. Department of Health & Human Services
Cathepsin B cleavage of the trypsinogen activation peptide

Background
          Cathepsin B is thought to play a central role in intrapancreatic trypsinogen activation and the onset of pancreatitis. A recent investigation of the cathepsin B mediated activability of wildtype trypsinogen and their mutations N29I, N29T and R122H, which are associated to hereditary pancreatitis, revealed no differences. This action seems to be restricted to the K23-I24 peptide bond, which is the trypsinogen activation bond. Here we investigated the influence of the mutations D22G and K23R of the trypsinogen activation peptide on the cleavability by cathepsin B.
        
        
          Methods
          To investigate the functional impact of the TAP mutations on cathepsin B mediated cleavage of the trypsinogen activating K23-I24 bond, the corresponding peptides pWT, APFDDDDKIVGG; pD22G, APFDDDGKIVGG; and pK23R, APFDDDDRIVGG were digested with cathepsin B for 30 min at pH 3.8 and 5.0, and the fragments were analysed by high-performance liquid chromatography.
        
        
          Results
          Without cathepsin B, less than 1 % of the peptides were hydrolysed. After a 30-minute digestion with cathepsin B at pH 5, 96% of pWT, 48% of pK23R, but only 2.4% of pD22G were hydrolysed. At pH 3.8, the cathepsin B cleavage of pWT and pK23R was less than at pH 5, whereas the cleavage of pD22G was completely inhibited
        
        
          Conclusions
          Cathepsin B mediated trypsinogen activation seems not to be a crucial pathogenic step in hereditary pancreatitis patients with the trypsinogen mutations D22G and K23R.

Tags: cathepsin-b, nih, pancreatitis-research, peptide-cleavage, trypsinogen-activation
Organization: U.S. Department of Health & Human Services
Alabama (AL)

This report presents estimates for measures of substance use and mental health based on the combined 2010 and 2011 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for Alabama for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: major-depressive-episode, mental-health, samhsa, serious-mental-illness, substance-use
Organization: U.S. Department of Health & Human Services
Table 26. 2011-2012 NSDUH Had at Least One Major Depressive Episode in the Past Year, by Age Group and State

Table 26. Had at Least One Major Depressive Episode in the Past Year, by Age Group and State: Percentages, Annual Averages Based on 2011 and 2012 NSDUHs. Results are provided by State and age groups.

Tags: depression-prevalence, major-depressive-episode, mental-health-statistics, nsduh-data, samhsa
Organization: U.S. Department of Health & Human Services
2013 CMHS Uniform Reporting System (URS) Table for Texas

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Tables for Texas for 2013. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program.  State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, noms-measures, samhsa, texas-mental-health
Organization: U.S. Department of Health & Human Services
Pennsylvania (PA)

This report presents Pennsylvania\'s estimates for 25 measures of substance use and mental health based on the combined 2009 and 2010 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for Pennsylvania for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: mental-health, nsduh, pennsylvania, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Long term benzodiazepine use for insomnia in patients over the age of 60: discordance of patient and physician perceptions

Background
          The aim of this study was to determine and compare patients' and physicians' perceptions of benefits and risks of long term benzodiazepine use for insomnia in the elderly.
        
        
          Methods
          A cross-sectional study (written survey) was conducted in an academic primary care group practice in Toronto, Canada. The participants were 93 patients over 60 years of age using a benzodiazepine for insomnia and 25 physicians comprising sleep specialists, family physicians, and family medicine residents. The main outcome measure was perception of benefit and risk scores calculated from the mean of responses (on a Likert scale of 1 to 5) to various items on the survey.
        
        
          Results
          The mean perception of benefit score was significantly higher in patients than physicians (3.85 vs. 2.84, p < 0.001, 95% CI 0.69, 1.32). The mean perception of risk score was significantly lower in patients than physicians (2.21 vs. 3.63, p < 0.001, 95% CI 1.07, 1.77).
        
        
          Conclusions
          There is a significant discordance between older patients and their physicians regarding the perceptions of benefits and risks of using benzodiazepines for insomnia on a long term basis. The challenge is to openly discuss these perceptions in the context of the available evidence to make collaborative and informed decisions.

Tags: benzodiazepine-use, insomnia-elderly, nih, patient-perception, physician-perception
Organization: U.S. Department of Health & Human Services
Acute-phase serum amyloid A production by rheumatoid arthritis
		  synovial tissue

Acute-phase serum amyloid A (A-SAA) is a major component of the
			 acute-phase response. A sustained acute-phase response in rheumatoid arthritis
			 (RA) is associated with increased joint damage. A-SAA mRNA expression was
			 confirmed in all samples obtained from patients with RA, but not in normal
			 synovium. A-SAA mRNA expression was also demonstrated in cultured RA
			 synoviocytes. A-SAA protein was identified in the supernatants of primary
			 synoviocyte cultures, and its expression colocalized with sites of macrophage
			 accumulation and with some vascular endothelial cells. It is concluded that
			 A-SAA is produced by inflamed RA synovial tissue. The known
			 association between the acute-phase response and progressive joint damage may
			 be the direct result of synovial A-SAA-induced effects on cartilage
			 degradation.

Tags: acute-phase-response, nih, rheumatoid-arthritis, serum-amyloid-a, synovial-tissue
Organization: U.S. Department of Health & Human Services
Emergency airway management by intensive care unit nurses with the intubating laryngeal mask airway and the laryngeal tube

When using the laryngeal tube and the intubating laryngeal mask airway (ILMA), the medium-size (maximum volume 1100 ml) versus adult (maximum volume 1500 ml) self-inflating bags resulted in significantly lower lung tidal volumes. No gastric inflation occurred when using both devices with either ventilation bag. The newly developed medium-size self-inflating bag may be an option to further reduce the risk of gastric inflation while maintaining sufficient lung ventilation. Both the ILMA and laryngeal tube proved to be valid alternatives for emergency airway management in the experimental model used.

Tags: airway-management, emergency-medicine, laryngeal-tube, nih, tidal-volume
Organization: U.S. Department of Health & Human Services
Kinetics of maternal immunity against rabies in fox cubs (

Background
          In previous experiments, it was demonstrated that maternal antibodies (maAb) against rabies in foxes (Vulpes vulpes) were transferred from the vixen to her offspring. However, data was lacking from cubs during the first three weeks post partum. Therefore, this complementary study was initiated.
        
        
          Methods
          Blood samples (n = 281) were collected from 64 cubs (3 to 43 days old) whelped by 19 rabies-immune captive-bred vixens. Sera was collected up to six times from each cub. The samples were analysed by a fluorescence focus inhibition technique (RFFIT), and antibody titres (nAb) were expressed in IU/ml. The obtained data was pooled with previous data sets. Subsequently, a total of 499 serum samples from 249 cubs whelped by 54 rabies-immune vixens were fitted to a non-linear regression model.
        
        
          Results
          The disappearance rate of maAb was independent of the vixens' nAb-titre. The maAb-titre of the cubs decreased exponentially with age and the half-life of the maAb was estimated to be 9.34 days. However, maAb of offspring whelped by vixens with high nAb-titres can be detected for longer by RFFIT than that of offspring whelped by vixens with relatively low nAb-titres. At a mean critical age of about 23 days post partum, maAb could no longer be distinguished from unspecific reactions in RFFIT depending on the amount of maAb transferred by the mother.
        
        
          Conclusions
          The amount of maAb cubs receive is directly proportional to the titre of the vixen and decreases exponentially with age below detectable levels in seroneutralisation tests at a relatively early age.

Tags: antibody-titres, fox-cubs, maternal-antibodies, nih, rabies-immunity
Organization: U.S. Department of Health & Human Services
The fission yeast COP9/signalosome is involved in cullin modification by ubiquitin-related Ned8p

Background
          The function of the fission yeast cullins Pcu1p and Pcu4p requires modification by the ubiquitin-related peptide Ned8p. A recent report by Lyapina et al. shows that the COP9/signalosome (CSN), a multifunctional eight subunit complex, regulates Ned8p modification of Pcu1p. Disruption of caa1/csn1, which encodes subunit 1 of the putative S. pombe CSN, results in accumulation of Pcu1p exclusively in the modified form. However, it remained unclear whether this reflects global control of all cullins by the entire CSN complex.
        
        
          Results
          We demonstrate that multiple CSN subunits control Ned8p modification of Pcu3p, another fission yeast cullin, which, in complex with the RING domain protein Pip1p, forms a ubiquitin ligase that functions in cellular stress response. Pcu3p is modified by Ned8p on Lys 729 and accumulates exclusively in the neddylated form in cells lacking the CSN subunits 1, 3, 4, and 5. These CSN subunits co-elute with Pcu3p in gel filtration fractions corresponding to ∼ 550 kDa and specifically bind both native and Ned8p-modified Pcu3p in vivo. While CSN does not influence the subcellular localization of Pcu3p, Pcu3p-associated in vitro ubiquitin ligase activity is stimulated in the absence of CSN.
        
        
          Conclusions
          Taken together, our data suggest that CSN is a global regulator of Ned8p modification of multiple cullins and potentially other proteins involved in cellular regulation.

Tags: cop9-signalosome, cullin-ned8-modification, fission-yeast, nih, pcu3p-ubiquitin-ligase
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Alaska, 2014

This is a behavioral health report for the state of Alaska. It uses the National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment Services (NSSATS) to address the topics of youth substance use, youth mental health and treatment, adult mental health and treatment, substance use, and substance use treatment for the years 2009 to 2013.

Tags: alaska-behavioral-health, mental-health-alaska, samhsa, substance-use-trends, youth-mental-health
Organization: U.S. Department of Health & Human Services
Associations of Nonmedical Pain Reliever Use and Initiation of Heroin Use in the United States

This CBHSQ data review uses 2002 through 2011 National Survey on Drug Use and Health (NSDUH) data to examine recent trends in heroin initiation, including the role of nonmedical prescription pain reliever use in the heroin trend among persons aged 12 to 49. Data are presented for various age groups, gender, race/ethnicity, household income, county type, and region.

Tags: heroin-initiation, nsduh-data, pain-reliever-misuse, samhsa, substance-use-disorder
Organization: U.S. Department of Health & Human Services