AndreaBozzo/ceres-open-data-index huggingface dataset:
Bulk RNA sequencing and single nuclei transcriptomics and epigenomics of brain tissue from mice flown on the RRRM-2 mission

In the Rodent Research Reference Mission (RRRM-2), forty female C57BL/6NTac mice were flown on the International Space Station. To assess differences in outcomes due to age, twenty 12 week-old and twenty 29 week-old mice were flown, respectively. To directly assess spaceflight effects, half of the young and old mice (10 old, 10 young) were sacrificed on-orbit after 55-58 days (ISS Terminal, ISS-T), while the other half (10 old, 10 young) were returned live to Earth after 32 days and allowed to recover for 24 days (Live Animal Return, LAR) before sacrifice. ISS-T and LAR mice were the same age at sacrifice. Both the ISS-T and LAR animals had independent ground controls (10 mice per group housed in flight hardware in matched environmental conditions), basal controls (10 mice per group sacrificed 2 days before launch), and vivarium controls (10 mice per group housed within standard vivarium habitats). Thus RRRM-2 included a total of 160 mice. This study includes bulk RNA sequencing and single nuclei transcriptomics and epigenomics from left cerebral hemispheres from 4 young ISS-T spaceflight animals, 5 old ISS-T spaceflight animals, 5 young ISS-T ground control animals, and 4 young ISS-T ground control animals.

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Organization: National Aeronautics and Space Administration
Transcriptional profiling of right extensor digitorum longus muscle from mice flown on the RR-23 mission

The objective of the Rodent Research-23 mission (RR-23) was to better understand the effects of spaceflight on the eyes, specifically on the structure and function of the arteries, veins, and lymphatic vessels that are needed to maintain vision. To this end, twenty male, C57BL/6J, 16-17 weeks-old mice were delivered to the International Space Station (ISS) on SpaceX-21 in a single transporter, transferred to two rodent habitats, and maintained in microgravity for 38 days. Flight mice were then returned to Earth alive (January 13th, 2021). After splashdown in the Atlantic Ocean, mice were transported to Kennedy Space Center via helicopter. The 20 Flight, 20 Habitat Ground Control (HGC), and 20 Vivarium Ground Control (VGC) mice were removed from Rodent Transporters (Flight and HGC) or vivarium cages (VGC), placed into shipping containers, and flown to Texas A and M University. There, mice underwent post-flight procedures, before euthanasia and tissue collection. Flight, HGC and VGC animals were euthanized and dissected on Jan 14th, 17th or 20th of 2021, respectively. Right extensor digitorum longus muscle samples were preserved by immersion in liquid nitrogen and stored at -80C until RNA was extracted, and libraries generated and sequenced (target 60 M clusters per sample, PE 150 bp). This dataset features 9 samples from the Flight group, 9 samples from the Habitat Ground Control group, and 9 samples from the Vivarium Ground Control group.

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Organization: National Aeronautics and Space Administration
Artificial gravity partially protects space-induced neurological deficits in Drosophila melanogaster

Spaceflight poses risks to the central nervous system (CNS), and understanding neurological responses is important for future missions. We report CNS changes in Drosophila aboard the International Space Station in response to spaceflight microgravity (SFμg) and artificially simulated Earth gravity (SF1g) via inflight centrifugation as a countermeasure. While inflight behavioral analyses of SFμg exhibit increased activity, postflight analysis displays significant climbing defects, highlighting the sensitivity of behavior to altered gravity. Multi-omics analysis shows alterations in metabolic, oxidative stress and synaptic transmission pathways in both SFμg and SF1g; however, neurological changes immediately postflight, including neuronal loss, glial cell count alterations, oxidative damage, and apoptosis, are seen only in SFμg. Additionally, progressive neuronal loss and a glial phenotype in SF1g and SFμg brains, with pronounced phenotypes in SFμg, are seen upon acclimation to Earth conditions. Overall, our results indicate that artificial gravity partially protects the CNS from the adverse effects of spaceflight. This study derives results from the in-flight video analysis (video recording assay).

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Organization: National Aeronautics and Space Administration
Fermi LAT Second Catalog of Gamma-Ray Pulsars (2PC)

This catalog summarizes 0.1 GeV gamma-ray pulsar detections using data acquired by the Large Area Telescope (LAT) on the Fermi satellite. These pulsars are neutron stars identified using LAT data through periodicity searches in gamma-ray and radio data around LAT unassociated source positions. The catalogued pulsars are divided into three groups: millisecond pulsars, young radio-loud pulsars, and young radio-quiet pulsars. This catalog summarizes results of the analysis of pulse profiles and energy spectra, and analysis of the off-peak phase intervals, and compares the gamma-ray properties with those in the radio, optical, and X-ray bands. Flux limits for pulsars with no observed gamma-ray emission are provided. This database was constructed by the HEASARC by combining the tabulated data in the psrcat.dat, spec.dat, offpk.dat and refs.dat obtained from &lt;a href="http://adsabs.harvard.edu/abs/2013yCat..22080017A"&gt;http://adsabs.harvard.edu/abs/2013yCat..22080017A&lt;/a&gt;. This is a service provided by NASA HEASARC .

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Organization: National Aeronautics and Space Administration
ROSETTA-ORBITER 67P RSI 1/2/3 COMET ESCORT 4 1301 V1.0

This is a Rosetta Radio Science data set, collected during the COMET ESCORT 4 phase 2015-10-22 to 2015-12-31. It is a Global Gravity measurement at the comet 67P and covers the time 2015-12-31T01:38:40.000 to 2015-12-31T07:32:55.000.

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Organization: National Aeronautics and Space Administration
Toward countering muscle and bone loss with spaceflight: GSK3 as a potential target (Tibialis Anterior, RR9, Western Blot)

We examined the effects of ~30 days of spaceflight on glycogen synthase kinase 3 (GSK3) content and inhibitory serine phosphorylation in murine muscle and bone samples from four separate missions (BION-M1, rodent research [RR]1, RR9, and RR18). Spaceflight reduced GSK3b content across all missions, whereas its serine phosphorylation was elevated with RR18 and BION-M1. The reduction in GSK3b was linked to the reduction in type IIA fibers commonly observed with spaceflight as these fibers are particularly enriched with GSK3. We then tested the effects of inhibiting GSK3 before this fiber type shift, and we demonstrate that muscle-specific Gsk3 knockdown increased muscle mass, preserved muscle strength, and promoted the oxidative fiber type with Earth-based hindlimb unloading. In bone, GSK3 activation was enhanced after spaceflight; and strikingly, muscle-specific Gsk3 deletion increased bone mineral density in response to hindlimb unloading. Thus, future studies should test the effects of GSK3 inhibition during spaceflight. This study derives results from the Western blot assay using tibialis anterior tissue from the RR9 mission. The tibialis anterior data in this study are related to other studies using tissues from the same experiment; OSD-654 (tibia), OSD-661 (lumbar spine), OSD-662 (soleus), OSD-663 (femur), and OSD-664 (extensor digitorum longus).

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Organization: National Aeronautics and Space Administration
GOLDSTONE MARS RADIO TELESCOPE DERIVED ALTIMETRY V1.0

This data set consists of Martian radii and elevations (relative to the 6 millibar reference surface) measured relative to JPL ephemeris DE_118. The data were obtained by the Goldstone Solar System Radar during the oppositions of 1971-1982. Present form of table generated by R. Mehlman, UCLA/IGPP.

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Organization: National Aeronautics and Space Administration
CGRO/EGRET Third Source Catalog

The Third EGRET Catalog of High-Energy Gamma-Ray Sources is based on data obtained by the Energetic Gamma-Ray Experiment Telescope (EGRET) on board the Compton Gamma-Ray Observatory (CGRO) during the period from 1991 April 22 to 1995 October 3, corresponding to GRO Cycles 1, 2, 3, and 4. EGRET is sensitive to photons in the energy range from about 30 MeV to over 20 GeV, the highest energies accessible by the CGRO instruments, and, like COMPTEL, is an imaging instrument. In addition to including more data than the Second EGRET Catalog (2EG, Thompson et al. 1995, ApJS, 101, 259) and its supplement (2EGS, Thompson et al. 1996, ApJS, 107, 227), this catalog uses completely reprocessed data so as to correct a number of mostly minimal errors and problems. The 271 sources (E &gt; 100 MeV) in the catalog include the single 1991 solar flare that was bright enough to detected as a source, the LMC, 5 pulsars, one probable radio galaxy detection (Cen A), and 66 high-confidence identifications of blazars (BL Lac objects, flat-spectrum radio quasars, or unidentified flat-spectrum radio sources). In addition, 27 lower-confidence potential blazar identifications are noted. Finally, the catalog contains 170 sources that are not yet firmly identified with known objects, although potential identifications have been suggested for a number of these. As already noted, there are 271 distinct sources in this catalog: since there are multiple measurements for these sources corresponding to the various viewing periods, there are 5246 entries in the HEASARC&#39;s version of the 3rd EGRET Catalog corresponding to the same number of lines in Table 4 of the published version. Thus, there are an average of about 20 entries for every distinct source. Notice that 14 sources reported in the 2nd EGRET Catalog or its supplement do not appear in this 3rd EGRET Catalog: 2EG J0403+3357, 2EG J0426+6618, 2EGS J0500+5902, 2EGS J0552-1026, 2EG J1136-0414, 2EGS J1236-0416, 2EG J1239+0441, 2EG J1314+5151, 2EG J1430+5356, 2EG J1443-6040, 2EG J1631-2845, 2EG J1709-0350, 2EG J1815+2950, and 2EG J2027+1054 due to the fact that the re-analysis of the EGRET data has dropped their statistical significance from just above the catalog threshold to just below it; additional information on these sources is provided in Table 5 of the published version of the 3rd EGRET Catalog. This database table was created by the HEASARC in June 1999, based on a machine-readable version of Table 4 of the 3rd EGRET Source Catalog that was provided by the CGRO Science Support Center (CGROSSC). Slight modifications to the Browse Object Classifications were later made in April 2001. This is a service provided by NASA HEASARC .

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Organization: National Aeronautics and Space Administration
Bulk RNA sequencing and single nuclei transcriptomics and epigenomics of brain tissue from mice flown on the RR-10 mission

The objective of the Rodent Research-10 mission (RR-10) was to investigate how spaceflight affects the cellular and molecular mechanisms of normal bone tissue regeneration in space. To this end, ten (10) 14-15 weeks-old female B6129SF2/J Wild Type (WT), and ten (10) 14-15 weeks-old female B6;129S2-Cdkn1atm1Tyj/J (p21-null) mice received a pre-flight subcutaneous injection of the bone marker (Alizarin Red), and were then delivered to the ISS aboard SpaceX-21. At 7 days before euthanasia, all 20 mice received an intraperitoneal (IP) injection with a bone formation marker (Calcein). At 48 +/- 2 hours before euthanasia, all 20 mice received an IP injection with a second dose of Calcein as well as a cell proliferation marker (BrdU). Then, following 28-29 days in microgravity, the Flight mice were euthanized. Following removal of hindlimbs, carcasses were wrapped in aluminum foil, preserved in the CryoChiller, and stored at -80 C or colder until return to Earth. In addition to the Flight group, three ground control groups were also part of the study: Basal (representing the pre-launch state), Vivarium (standard vivarium housing for the same duration of time as flight), and Ground (flight habitat in the International Space Station Environment Simulator, ISSES). Twenty mice (10 of each strain) were included in each of these control groups (except Vivarium which included 12 of each strain). These were treated, euthanized and processed on the same schedule and in the same manner as the flight samples. This study includes bulk RNA sequencing data from left cerebral hemispheres from 4 WT flight animals and 5 WT ground control animals, and single nuclei transcriptomics and epigenomics data from left cerebral hemispheres from 5 WT flight animals, and 5 WT ground control animals.

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Organization: National Aeronautics and Space Administration
Transcriptional profiling of colon from mice flown on the RR-10 mission

The objective of the Rodent Research-10 mission (RR-10) was to investigate how spaceflight affects the cellular and molecular mechanisms of normal bone tissue regeneration in space. To this end, ten (10) 14-15 weeks-old female B6129SF2/J Wild Type (WT), and ten (10) 14-15 weeks-old female B6;129S2-Cdkn1atm1Tyj/J (p21-null) mice received a pre-flight subcutaneous injection of the bone marker (Alizarin Red), and were then delivered to the ISS aboard SpaceX-21. At 7 days before euthanasia, all 20 mice received an intraperitoneal (IP) injection with a bone formation marker (Calcein). At 48 +/- 2 hours before euthanasia, all 20 mice received an IP injection with a second dose of Calcein as well as a cell proliferation marker (BrdU). Then, following 28-29 days in microgravity, the Flight mice were euthanized. Following removal of hindlimbs, carcasses were wrapped in aluminum foil, preserved in the CryoChiller, and stored at -80 C or colder until return to Earth. In addition to the Flight group, three ground control groups were also part of the study: Basal (representing the pre-launch state), Vivarium (standard vivarium housing for the same duration of time as flight), and Ground (flight habitat in the International Space Station Environment Simulator, ISSES). Twenty mice (10 of each strain) were included in each of these control groups (except Vivarium which included 12 of each strain). These were treated, euthanized and processed on the same schedule and in the same manner as the flight samples. This study includes bulk RNA sequencing ribodepleted gene expression data from 10 Basal animals (5 WT and 5 p21-null), 9 Flight animals (4 WT and 5 p21-null), 10 Ground animals (5 WT and 5 p21-null), and 10 Vivarium animals (5 WT and 5 p21-null).

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Organization: National Aeronautics and Space Administration
ROSETTA-ORBITER EARTH OSIWAC 4 EAR2 RDR-STR-REFL V1.0

This CODMAC level 4 data set contains solar stray light corrected, radiometric calibrated and geometric distortion corrected (resampled) image data in in reflectance units  (normalized and thus without unit),  acquired by the OSIRIS Wide Angle Camera on the Rosetta spacecraft  during the EARTH SWING-BY 2 mission phase, covering the period  from 2007-09-13T00:00:00.000 to 2008-01-27T23:59:59.000. The prime target is planet Earth. This version V1.0 is the first version of this dataset.

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Organization: National Aeronautics and Space Administration
SAGE-Var LMC Variable Catalog

SAGE-Var is a follow-up to the SAGE and SAGE-SMC Legacy programs. The SAGE-Var program obtained 4 epochs of photometry at 3.6 and 4.5 microns covering the bar of the Large Magellanic Cloud (LMC) and the central region of the Small Magellanic Cloud (SMC) in order to probe the variability of extremely red sources missed by variability surveys conducted at shorter wavelengths, and to provide additional epochs of observation for known variables. The 6 total epochs of observations probe infrared variability on 15 different timescales ranging from 20 days to 5 years.

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Organization: National Aeronautics and Space Administration
Quantifying Cancellous Bone Structural Changes in Microgravity: Axial Skeleton Results from the RR-1 Mission

Objective of this study was to further validate bone degradation in microgravity as site-specific and preferential to weight bearing bone. An objective of this study was to further understand the role of the mechanical environment in controlling the process of bone remodeling, namely local formation and resorption to maintain a healthy structure. These data from the lumbar 4 bones of Rodent Research-1 mission aboard the International Space Station, are unpublished, and were presented at the 2016 meeting of the American Society for Gravitational Space Research. This dataset derives results from the micro–computed tomography (mCT) assay.

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Organization: National Aeronautics and Space Administration
ROSETTA-ORBITER 67P RSI 1/2/3 COMET ESCORT 3 1029 V1.0

This is a Rosetta Radio Science data set, collected during the COMET ESCORT 3 phase 2015-07-01 to 2015-10-21. It is a Global Gravity measurement at the comet 67P and covers the time 2015-09-13T03:07:50.000 to 2015-09-13T09:43:10.500.

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Organization: National Aeronautics and Space Administration
Bright Extra-Galactic AT20G Sources Polarizations Catalog

This table contains polarization data for 180 extragalactic sources extracted from the Australia Telescope 20-GHz (AT20G) survey catalog and observed with the Australia Telescope Compact Array (ATCA) during a dedicated, high sensitivity run (sigma&lt;sub&gt;P&lt;/sub&gt; ~ 1 mJy). For the sake of completeness, the authors extracted the polarization information for seven extended sources from the 9-yr Wilkinson Microwave Anisotropy Probe co-added maps at 23 GHz. The full sample of 187 sources constitutes a ~ 99% complete sample of extragalactic sources brighter than S&lt;sub&gt;20GHz&lt;/sub&gt; = 500 mJy at the selection epoch with Declination below -30&lt;sup&gt;o&lt;/sup&gt;. The sample has a 91.4% detection rate in polarization at ~ 20 GHz (94% if considering the sub-sample of point-like sources). The authors have measurements also at 4.8 and 8.6 GHz within ~1 month of the 20-GHz observations for 172 sources so as to reconstruct the spectral properties of the sample in total intensity and in polarization: 143 of them have a polarization detection at all three frequencies. The authors find that there is no statistically significant evidence of a relationship either between the fraction of polarization and frequency or between the fraction of polarization and the total intensity flux density. This indicates that Faraday depolarization is not very important above 4.8 GHz and that the magnetic field is not substantially more ordered in the regions dominating the emission at higher frequencies (up to 20 GHz). The authors estimate the distribution of the polarization fraction and the polarized flux density source counts at ~20 GHz. The selection of the sample was based on the list of confirmed AT20G sources available at the epoch of these observations (2006 October). The authors selected all objects with flux density S&lt;sub&gt;20GHz&lt;/sub&gt; &gt; 500 mJy and Declination below -30&lt;sup&gt;o&lt;/sup&gt;, excluding the Galactic plane region (|b| &lt;= 1.5o^) and the Large Magellanic Cloud (LMC) region (inside a circle of 5.5&lt;sup&gt;o&lt;/sup&gt; radius centered at RA =05:23:34.7 and Dec=-69:45:22 in J2000.0 coordinates). This resulted in a complete sample of 189 sources. The observations were taken on October 1, 2006 using the most compact hybrid configuration of ATCA, H75, excluding the data from the farthest antenna. The longest baseline of this configuration is 75 m, and its T-shape ensures adequate Fourier coverage for snapshots taken on a relatively small range of hour angles and at high elevation. In a number of cases, indicated by source_flags values of &#39;s&#39;, &#39;f&#39; or &#39;w&#39;, the highest frequency data is not at 18 GHz, but at 20 or 23 GHz. This table was created by the HEASARC in January 2015 based on the &lt;a href="https://cdsarc.cds.unistra.fr/ftp/cats/J/MNRAS/436/2915"&gt;CDS Catalog J/MNRAS/436/2915&lt;/a&gt; file table2.dat. This is a service provided by NASA HEASARC .

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Organization: National Aeronautics and Space Administration
SAGE MIPS 160 micron Full List

The Spitzer Space Telescope Survey of the Large Magellanic Cloud Legacy Project Surveying the Agents of a Galaxy's Evolution (SAGE) traces the life cycle of observable matter that drives the evolution of a galaxy's appearance. SAGE has revealed over 6 million sources including ~150,000 evolved stars, ~50,000 young stellar objects and the diffuse interstellar medium with column densities > 1.2×1021 cm -2. The data will provide fundamental insights into the physical processes of the interstellar medium, the formation of new stars and the injection of mass by evolved stars and their relationships on the galaxy-wide scale of the Large Magellanic Cloud.\n\nTo be included in a Catalog, each source has to meet a number of criteria. The source had to be nearly point like with a correlation value 0.89. In regions where there is a significant structure in the surrounding region (identified as having a sigma > 0.25 in a 120" width square box), the source had to have a correlation value >0.91. There are a small number of sources with 24 um magnitudes between 4 and 8 which have unusually low uncertainties (i.e., high S/N). The origin of these sources is under investigation and seems to be related to edge effects in the AORs. In the meantime, these sources were removed from the 24 um catalogs. Finally, all sources had to have signal-to-noise values >5. The final catalogs likely have a few remaining unreliable sources, but we estimate this to be at the less than 1% error.\n\nThe Full Lists contain ALL the sources extracted from the mosaics, thus a user should be aware that it contains spurious sources. The full list may be useful to search for the potential counterparts to known sources.

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Organization: National Aeronautics and Space Administration
Characterization of Biofilm Formation, Growth, and Gene Expression on Different Materials and Environmental Conditions in Microgravity (Gene expression of Pseudomonas aeruginosa biofilms)

Microorganisms' natural ability to live as organized multicellular communities – also known as biofilms – provides them with unique survival advantages. For instance, biofilms are protected against environmental stresses thanks to their extracellular matrix, which could contribute to persistent infections after treatment. Biofilms are also capable of strongly attaching to surfaces, where their metabolism byproducts could lead to surface material degradation. Furthermore, microgravity can alter biofilm behavior in unexpected ways, making the presence of biofilms in space a risk for both astronauts and spaceflight hardware. Despite the efforts to eliminate microorganism contamination from spacecrafts surfaces, it is impossible to prevent human-associated bacteria or fungus from eventually establishing biofilm surface colonization. Nevertheless, by understanding the changes that biofilms undergo in microgravity, it is possible to identify key differences and pathways that could be targeted to significantly reduce biofilm formation. The Space Biofilms project, performed at the International Space Station, contributes to such understanding by characterizing the morphology and gene expression of bacterial and fungal biofilms formed in microgravity with respect to ground controls. Pseudomonas aeruginosa was used as model organism for the bacterial morphology and transcriptomic studies, while Penicillium rubens was used for the fungal morphology study. Bacterial biofilm formation was characterized at one, two, and three days of incubation (37°C) over six different materials: stainless steel 316, passivated stainless steel 316, a lubricant impregnated surface (LIS), catheter grade silicone with and without a linear microtopography, and cellulose membrane.

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Organization: National Aeronautics and Space Administration