AndreaBozzo/ceres-open-data-index huggingface dataset:
Decreases in blood perfusion of the anterior cingulate gyri in Anorexia Nervosa Restricters assessed by SPECT image analysis

Background
          It is possible that psychopathological differences exist between the restricting and bulimic forms of anorexia nervosa. We investigated localized differences of brain blood flow of anorexia nervosa patients using SPECT image analysis with statistic parametric mapping (SPM) in an attempt to link brain blood flow patterns to neurophysiologic characteristics.
        
        
          Methods
          The subjects enrolled in this study included the following three groups: pure restrictor anorexics (AN-R), anorexic bulimics (AN-BP), and healthy volunteers (HV). All images were transformed into the standard anatomical space of the stereotactic brain atlas, then smoothed. After statistical analysis of each brain image, the relationships among images were evaluated.
        
        
          Results
          SPM analysis of the SPECT images revealed that the blood flow of frontal area mainly containing bilateral anterior cingulate gyri (ACC) was significantly decreased in the AN-R group compared to the AN-BP and HV groups.
        
        
          Conclusions
          These findings suggest that some localized functions ofthe ACCare possibly relevant to the psychopathological aspects of AN-R.

Tags: anorexia-nervosa, anterior-cingulate-gyrus, brain-perfusion, nih, spect-imaging
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Oregon, 2013

This is a behavioral health report for the state of Oregon. It uses the  National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment Services (NSSATS) to address the topics of youth substance use , youth mental health and treatment, adult mental health and treatment, substance use, substance use treatment for the years 2008 to 2012.

Tags: adult-mental-health, oregon-behavioral-health, samhsa, substance-abuse-treatment, youth-substance-use
Organization: U.S. Department of Health & Human Services
The human exosome: an autoantigenic complex of exoribonucleases in myositis and scleroderma

The anti-PM/Scl autoantibodies are known to characterize a subset of autoimmune patients with myositis, scleroderma (Scl), and the PM/Scl overlap syndrome. The major autoantigens that are recognized by anti-PM/Scl autoantibodies are designated PM/Scl-100 and PM/Scl-75. These autoantigens have been reported to associate into a large complex consisting of 11 to 16 proteins and to play a role in ribosome synthesis. Recently, it was discovered that the PM/Scl complex is the human counterpart of the yeast (Saccharomyces cerevisiae) exosome, which is an RNA-processing complex consisting of 11 3' → 5' exoribonucleases. To date, 10 human exosome components have been identified, although only some of these were studied in more detail. In this review, we discuss some recent advances in the characterization of the PM/Scl complex.

Tags: autoimmune-diseases, myositis, nih, pmscl-complex, scleroderma
Organization: U.S. Department of Health & Human Services
2012 State Profile - Kansas

This is a National Survey of Substance Abuse Treatment Services (N-SSATS) annual report showing the state profile for Kansas in 2012. N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 States, the District of Columbia, and other U.S. jurisdictions.

Tags: behavioral-health-services, kansas, n-ssats, samhsa, substance-abuse-treatment
Organization: U.S. Department of Health & Human Services
The life cycle of chondrocytes in the developing skeleton

Cartilage serves multiple functions in the developing embryo and in postnatal life. Genetic mutations affecting cartilage development are relatively common and lead to skeletal malformations, dysfunction or increased susceptibility to disease or injury. Characterization of these mutations and investigation of the molecular pathways in which these genes function have contributed to an understanding of the mechanisms regulating skeletal patterning, chondrogenesis, endochondral ossification and joint formation. Extracellular growth and differentiation factors including bone morphogenetic proteins, fibroblast growth factors, parathyroid hormone-related peptide, extracellular matrix components, and members of the hedgehog and Wnt families provide important signals for the regulation of cell proliferation, differentiation and apoptosis. Transduction of these signals within the developing mesenchymal cells and chondrocytes results in changes in gene expression mediated by transcription factors including Smads, Msx2, Sox9, signal transducer and activator of transcription (STAT), and core-binding factor alpha 1. Further investigation of the interactions of these signaling pathways will contribute to an understanding of cartilage growth and development, and will allow for the development of strategies for the early detection, prevention and treatment of diseases and disorders affecting the skeleton.

Tags: chondrocyte-development, chondrocytes, endochondral-ossification, nih, skeletal-malformations
Organization: U.S. Department of Health & Human Services
2010 State Profile — Texas

This state profile includes data from facilities in Texas that reported to N-SSATS for the survey reference date March 31, 2010. Data were collected on the location, characteristics, services offered, and number of clients in treatment at alcohol and drug abuse treatment facilities (both public and private) in Texas. In Texas, 454 substance abuse treatment facilities were included in the 2010 N-SSATS, reporting that there were 33,113 clients in substance abuse treatment on March 31, 2010. The survey response rate in Texas was 89.2%.

Tags: n-ssats, samhsa, substance-abuse-treatment, texas, treatment-facilities
Organization: U.S. Department of Health & Human Services
Compound 525221: Dodecyl heptafluorobutanoate

Chemical compound data from PubChem database. IUPAC Name: dodecyl 2,2,3,3,4,4,4-heptafluorobutanoate. Molecular Formula: C16H25F7O2. Molecular Weight: 382.36. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
The Proliferation REduction with Vascular ENergy Trial (PREVENT)

PREVENT was the first prospective, randomized placebo-controlled study of intracoronary beta radiotherapy with 32P. A total of 105 patients with de novo or restenotic lesions, treated by stenting or balloon angioplasty, received 0 (control), 16, 20, or 24 Gy to a depth of 1 mm beyond the lumen surface. Rates of restenosis (50% diameter stenosis or more) were significantly lower in radiotherapy patients at the target site (8% compared with 39%, P = 0.012) and at the target site plus adjacent segments (22% compared with 50%, P = 0.018). Stenosis adjacent to the target site and late thrombotic events reduced the overall clinical benefit of radiotherapy.

Tags: beta-radiotherapy, coronary-restenosis, nih, stent-angioplasty, vascular-energy
Organization: U.S. Department of Health & Human Services
Research Article: Journal of Biomedicine and Biotechnology

An intense suppression of T cell proliferation to mitogens and to
antigens is observed in a large number of parasitic infections.
The impairment of T cell proliferation also occurred during the
acute phase of Chagas' disease, caused by the intracellular
protozoan parasite Trypanosoma cruzi. A wealth of
evidence has accumulated that illustrates the ability of
T. cruzi released molecules to influence directly a
variety of diverse immunological functions. In this paper, we
review the data concerning the immunoregulatory effects of
T. cruzi Tc24 (a B cell activator antigen) and Tc52 (an
immunosuppressive protein) released molecules on the host immune
system. The gene targeting approach developed to further explore
the biological function(s) of Tc52 molecule, revealed interesting
unexpected functional properties. Indeed, in addition to its
immunusuppressive activity a direct or indirect involvement of
Tc52 gene product alone or in combination with other
cellular components in T. cruzi differentiation control
mechanisms have been evidenced. Moreover, targeted Tc52
replacement allowed the obtention of parasite mutants exhibiting
low virulence in vitro and in vivo. Thus, the
generation of a complete deficiency state of virulence factors by
gene targeting should provide a means to assess the importance of
these factors in the pathophysiological processes and disease
progression. It is hoped that such approaches might allow
rational design of tools to control T. cruzi
infections.

Tags: chagas-disease, immunosuppression, nih, t-cell-proliferation, trypanosoma-cruzi
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Louisiana, 2013

This is a behavioral health report for the state of Louisiana. It uses the  National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment Services (NSSATS) to address the topics of youth substance use , youth mental health and treatment, adult mental health and treatment, substance use, substance use treatment for the years 2008 to 2012.

Tags: behavioral-health, louisiana, mental-health, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Gene therapy for lipid disorders

Lipid disorders are associated with atherosclerotic vascular disease, and therapy is associated with a substantial reduction in cardiovascular events. Current approaches to the treatment of lipid disorders are ineffective in a substantial number of patients. New therapies for refractory hypercholesterolemia, severe hypertriglyceridemia, and low levels of high-density lipoprotein cholesterol are needed: somatic gene therapy is one viable approach. The molecular etiology and pathophysiology of most of the candidate diseases are well understood. Animal models exist for the diseases and in many cases preclinical proof-of-principle studies have already been performed. There has been progress in the development of vectors that provide long-term gene expression. New clinical gene therapy trials for lipid disorders are likely to be initiated within the next few years.

Tags: atherosclerotic-disease, gene-therapy, hypercholesterolemia, lipid-disorders, nih
Organization: U.S. Department of Health & Human Services
Treatment Episode Data Set (TEDS): 2013, National Discharge From Substance Abuse Treatment Services

This report presents data from the Treatment Episode Data Set (TEDS) for discharges from treatment in 2013. It is a companion to the reports Treatment Episode Data Set (TEDS): 2003-2013 National Admissions to Substance Abuse Treatment and Treatment Episode Data Set (TEDS): 2003-2013 State Admissions to Substance Abuse Treatment. These reports provide information on the demographic and substance abuse characteristics of substance abuse treatment admissions and discharges aged 12 and older in facilities that report to individual state administrative data systems. In addition, characteristics used to analyze changes from admission to discharge among the linked admission and discharge records are included. Primary substance of abuse, frequency of use, and employment status at admission are repeated in several tables. This is done so that characteristics at admission and discharge can be appropriately compared with each other and to ensure the inclusion of important data that might otherwise be overlooked. Data in this report include records for discharges during calendar year 2013 that were received and processed through February 1, 2016.

Tags: samhsa, substance-abuse-treatment, substance-use-disorders, teds, treatment-discharge-data
Organization: U.S. Department of Health & Human Services
National Youth In Transition Database Notice of Proposed RuleMaking

National Youth In Transition Database Notice of Proposed RuleMaking
  
  

 (PDF) - This proposed rule implements the data collection requirements of the Foster Care Independence Act of 1999 (P.L. 106–169), as incorporated into the Social Security Act at section 477.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: data, foster, policy, regulation, reporting
Organization: U.S. Department of Health & Human Services
2023 National Directory of Mental Health Treatment Facilities

TheNational Directory of Mental Health Treatment Facilities - 2023is a listing of federal, state, and local government facilities and private facilities that provide mental health treatment services. It includes treatment facilities that responded to the 2022 National Substance Use and Mental Health Services Survey (N-SUMHSS). The information about each facility that appears in this Directory was provided by that facility in response to the 2022 N-SUMHSS. The N-SUMHSS is conducted annually by the Substance Abuse and Mental Health Services Administration (SAMHSA). The 2023 Directory is available in PDF and Excel formats.The Directory is ordered alphabetically by state, by city within each state, and by facility name within each city. Each facility listing includes codes that represent the services offered and other features of the facility, including codes that indicate services for hearing impaired and non-English-speaking clients. Codes are defined in a key shown on pages v-x of the PDF file and as a separate tab on the Excel version. Please note services offered by a particular facility may change over time. It is suggested to verify the information in this Directory when contacting a facility.

Tags: behavioral-health, facility-directory, mental-health-facilities, samhsa, treatment-services
Organization: U.S. Department of Health & Human Services
2013 CMHS Uniform Reporting System Output Tables

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2013. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, national-outcome-measures, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
2017 Methodological Summary and Definitions

This report is organized into seven sections. Section A describes the survey, including information about the sample design, data collection procedures, and key aspects of data processing (e.g., development of analysis weights). Section B presents technical details on the statistical methods and measurement, such as suppression criteria for unreliable estimates, statistical testing procedures, and issues for selected substance use and mental health measures. Section C discusses special topics related to prescription psychotherapeutic drugs. A glossary that covers key definitions used in NSDUH reports and tables is included in Section D. Section E describes other sources of data on substance use and mental health issues, including data sources for populations outside the NSDUH target population. A list of references cited in the report (Section F) and a list of contributors to this report (Section G) also are provided.

Tags: data-definitions, mental-health, samhsa, substance-use, survey-methodology
Organization: U.S. Department of Health & Human Services
Identification of conserved C2H2 zinc-finger gene families in the Bilateria

Background:
          Identification of orthologous relationships between genes from widely divergent taxa allows partial reconstruction of the gene complement of ancestral genomes. C2H2 zinc-finger genes are one of the largest and most complex gene superfamilies in metazoan genomes, with hundreds of members in the human genome. Here we analyze C2H2 zinc-finger genes from three taxa - Drosophila, Caenorhabditis elegans and human - from which near-complete genome sequence data are available.
        
        
          Results:
          Our analyses conclusively identify 39 families of genes, of which 38 can be defined as orthology groups in that they are descended from single ancestral genes in the common ancestor of Drosophila, C. elegans and humans.
        
        
          Conclusions:
          On the basis of current metazoan phylogeny, these 39 groups represent the minimum complement of C2H2 zinc-finger genes present in the genome of the bilaterian common ancestor.

Tags: gene-families, genome-mapping, nih, orthology-groups, zinc-finger-genes
Organization: U.S. Department of Health & Human Services
Phoenix: Drug-Related Emergency Department Visits, 2004-2011 - Suicide Attempts

Excel file with estimates, rates, relative standard errors, trends and confidence intervals for all drug-related emergency department (ED) visits involving suicide attempts in the Phoenix metropolitan area, covering 2004-2011.  Drug-related suicide attempts include visits for drug overdoses and for suicide attempts by other means (e.g., using a firearm) if drugs were involved or related to the suicide attempt.

Tags: drug-overdose, emergency-department, phoenix-metro-area, samhsa, suicide-attempts
Organization: U.S. Department of Health & Human Services
Role of gammadelta T cells in protecting normal airway function

Since their discovery 15 years ago, the role of γδ T cells has remained somewhat elusive. Responses of γδ T cells have been found in numerous infectious and non-infectious diseases. New evidence points to γδ T cells' functioning in the airways to maintain normal airway responsiveness or tone. In the lung, distinct subsets of γδ T cell subsets seem to have specific roles, one subset promoting allergic inflammation, the other serving a protective role.

Tags: airway-responsiveness, asthma-research, gamma-delta-t-cells, immunology, nih
Organization: U.S. Department of Health & Human Services
2013-2014 NSDUH State Estimates of Substance Use and Mental Disorders

State estimates for 25 measures of substance use and mental disorders based on the combined 2013 and 2014 National Surveys on Drug Use and Health (NSDUHs) are provided. Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Results are provided by State and for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older, and all persons 12 or older. State and census region estimates are based on a small area estimation (SAE) methodology in which State-level NSDUH data are combined with county and census block group/tract-level data from the State.

Tags: mental-disorders, samhsa, small-area-estimation, state-estimates, substance-use
Organization: U.S. Department of Health & Human Services
Results from the 2014 National Survey on Drug Use and Health:  Detailed Tables

Results from the 2014 National Survey on Drug Use and Health: Detailed Tables is a collection of tables presenting national estimates from the National Survey on Drug Use and Health (NSDUH). These tables present information on drug, alcohol, and tobacco use, as well as drug and alcohol dependence and abuse and treatment. Measures of these behaviors and characteristics are presented by a variety of demographic, geographic, and other variables. The estimates in the tables include rates of the behaviors, numbers of persons engaging in these behaviors, and other measures. Although the majority of these tables are trend tables presenting estimates from the 2013 and 2014 NSDUHs, some tables include only estimates from the 2014 NSDUH.

Tags: alcohol-tobacco-use, mental-health, nsduh-survey, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Molecular diversity of phospholipase D in angiosperms

Background
          The phospholipase D (PLD) family has been identified in plants by recent molecular studies, fostered by the emerging importance of plant PLDs in stress physiology and signal transduction. However, the presence of multiple isoforms limits the power of conventional biochemical and pharmacological approaches, and calls for a wider application of genetic methodology.
        
        
          Results
          Taking advantage of sequence data available in public databases, we attempted to provide a prerequisite for such an approach. We made a complete inventory of the Arabidopsis thaliana PLD family, which was found to comprise 12 distinct genes. The current nomenclature of Arabidopsis PLDs was refined and expanded to include five newly described genes. To assess the degree of plant PLD diversity beyond Arabidopsis we explored data from rice (including the genome draft by Monsanto) as well as cDNA and EST sequences from several other plants. Our analysis revealed two major PLD subfamilies in plants. The first, designated C2-PLD, is characterised by presence of the C2 domain and comprises previously known plant PLDs as well as new isoforms with possibly unusual features-catalytically inactive or independent on Ca2+. The second subfamily (denoted PXPH-PLD) is novel in plants but is related to animal and fungal enzymes possessing the PX and PH domains.
        
        
          Conclusions
          The evolutionary dynamics, and inter-specific diversity, of plant PLDs inferred from our phylogenetic analysis, call for more plant species to be employed in PLD research. This will enable us to obtain generally valid conclusions.

Tags: angiosperms, molecular-diversity, nih, phospholipase-d, plant-physiology
Organization: U.S. Department of Health & Human Services
Compound 527279: Propanoic acid, 2-iodoethyl ester

Chemical compound data from PubChem database. IUPAC Name: 2-iodoethyl propanoate. Molecular Formula: C5H9IO2. Molecular Weight: 228.03. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2019 NSDUH Annual National Report

Read key findings from the 2019 National Survey on Drug Use and Health (NSDUH) on substance use, mental health, and treatment by age group. Metrics in the report cover the civilian, noninstitutionalized US population ages 12 and older. The report covers both current conditions and trends over time.Along with the full report, a set of slides is available that displays figures from the report.

Tags: mental-health, national-survey, samhsa, substance-use, treatment-utilization
Organization: U.S. Department of Health & Human Services
2022 Uniform Reporting System (URS) Table For Michigan

This is the 2022 Uniform Reporting System (URS) Output Tables for Michigan. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: mental-health-services, michigan-mental-health, national-outcome-measures, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services