AndreaBozzo/ceres-open-data-index huggingface dataset:
Functional interaction between TRP4 and CFTR in mouse aorta endothelial cells

Background
          This study describes the functional interaction between the putative Ca2+ channel TRP4 and the cystic fibrosis transmembrane conductance regulator, CFTR, in mouse aorta endothelium (MAEC).
        
        
          Results
          MAEC cells express CFTR transcripts as shown by RT-PCR analysis. Application of a phosphorylating cocktail activated a Cl- current with characteristics similar to those of CFTR mediated currents in other cells types (slow activation by cAMP, absence of rectification, block by glibenclamide). The current is present in trp4 +/+ MAEC, but not in trp4 -/- cells, although the expression of CFTR seems unchanged in the trp4 deficient cells as judged from RT-PCR analysis.
        
        
          Conclusions
          It is concluded that TRP4 is necessary for CFTR activation in endothelium, possibly by providing a scaffold for the formation of functional CFTR channels.

Tags: aorta-endothelium, cftr-function, mouse-model, nih, trp4-channel
Organization: U.S. Department of Health & Human Services
Blockade of maitotoxin-induced oncotic cell death reveals zeiosis

Background
          Maitotoxin (MTX) initiates cell death by sequentially activating 1) Ca2+ influx via non-selective cation channels, 2) uptake of vital dyes via formation of large pores, and 3) release of lactate dehydrogenase, an indication of cell lysis. MTX also causes formation of membrane blebs, which dramatically dilate during the cytolysis phase. To determine the role of phospholipase C (PLC) in the cell death cascade, U73122, a specific inhibitor of PLC, and U73343, an inactive analog, were examined on MTX-induced responses in bovine aortic endothelial cells.
        
        
          Results
          Addition of either U73122 or U73343, prior to MTX, produced a concentration-dependent inhibition of the cell death cascade (IC50 ≈ 1.9 and 0.66 μM, respectively) suggesting that the effect of these agents was independent of PLC. Addition of U73343 shortly after MTX, prevented or attenuated the effects of the toxin, but addition at later times had little or no effect. Time-lapse videomicroscopy showed that U73343 dramatically altered the blebbing profile of MTX-treated cells. Specifically, U73343 blocked bleb dilation and converted the initial blebbing event into "zeiosis", a type of membrane blebbing commonly associated with apoptosis. Cells challenged with MTX and rescued by subsequent addition of U73343, showed enhanced caspase-3 activity 48 hr after the initial insult, consistent with activation of the apoptotic program.
        
        
          Conclusions
          Within minutes of MTX addition, endothelial cells die by oncosis. Rescue by addition of U73343 shortly after MTX showed that a small percentage of cells are destined to die by oncosis, but that a larger percentage survive; cells that survive the initial insult exhibit zeiosis and may ultimately die by apoptotic mechanisms.

Tags: cell-death-pathways, endothelial-cells, maitotoxin-toxicity, nih, zeiosis
Organization: U.S. Department of Health & Human Services
Compound 525143: Decaethylene glycol, monoallyl ether, acetate

Chemical compound data from PubChem database. IUPAC Name: 2-[2-[2-[2-[2-[2-[2-[2-[2-(2-prop-2-enoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl acetate. Molecular Formula: C25H48O12. Molecular Weight: 540.6. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 525203: Chloromethyl 3-chloro-octanoate

Chemical compound data from PubChem database. IUPAC Name: chloromethyl 3-chlorooctanoate. Molecular Formula: C9H16Cl2O2. Molecular Weight: 227.12. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Is there a clinically significant gender bias in post-myocardial infarction pharmacological management in the older (>60) population of a primary care practice?

Background
          Differences in the management of coronary artery disease between men and women have been reported in the literature. There are few studies of potential inequalities of treatment that arise from a primary care context. This study investigated the existence of such inequalities in the medical management of post myocardial infarction in older patients.
        
        
          Methods
          A comprehensive chart audit was conducted of 142 men and 81 women in an academic primary care practice. Variables were extracted on demographic variables, cardiovascular risk factors, medical and non-medical management of myocardial infarction.
        
        
          Results
          Women were older than men. The groups were comparable in terms of cardiac risk factors. A statistically significant difference (14.6%: 95% CI 0.048–28.7 p = 0.047) was found between men and women for the prescription of lipid lowering medications. 25.3% (p = 0.0005, CI 11.45, 39.65) more men than women had undergone angiography, and 14.4 % (p = 0.029, CI 2.2, 26.6) more men than women had undergone coronary artery bypass graft surgery.
        
        
          Conclusion
          Women are less likely than men to receive lipid-lowering medication which may indicate less aggressive secondary prevention in the primary care setting.

Tags: gender-disparities, lipid-lowering-drugs, myocardial-infarction, nih, primary-care
Organization: U.S. Department of Health & Human Services
Survey of stress ulcer prophylaxis

Background:
          No surveys of stress ulcer prophylaxis prescribing in the USA have
been conducted since 1995. Since that time, the most comprehensive meta-analysis
and largest randomized study to date concerning stress ulcer prophylaxis have
been published.
        
        
          Results:
          Three hundred sixty-eight surveys were sent to all members of the
Section of Pharmacy and Pharmacology of the Society of Critical Care Medicine.
One hundred fifty-three (42%) surveys were returned. Representatives from 86%
of institutions stated that medications for stress ulcer prophylaxis are used
in a majority (>90%) of patients admitted to the intensive care unit (ICU).
Twenty-two per cent of institutions have recommendations for both ICU and
non-ICU settings. Fifty-eight per cent of institutions stated that there was
one preferred medication for stress ulcer prophylaxis, and in 77% of these
histamine-2-antagonists were the most popular.
        
        
          Conclusions:
          There are wide variations in prescribing practices for stress
ulcer prophylaxis. Institutions should consult published literature and use
pre-existing guidelines as templates for developing their own guidelines.

Tags: histamine-2-antagonists, icu-medication-use, nih, pharmacy-survey, stress-ulcer-prophylaxis
Organization: U.S. Department of Health & Human Services
Dr. Elinore F. McCance-Katz, Webcast slides, National Survey on Drug Use and Health: 2018

View therecorded presentation(link is external)of the NSDUH data and webcast slides (PDF|PPT) presented by Dr. Elinore F. McCance-Katz.

Tags: mental-health, nsduh-2018, samhsa, substance-use, survey-data
Organization: U.S. Department of Health & Human Services
Compound 527319: 3-Methoxy-2-(3-oxobutyl)-4,5-diphenylcyclopent-3-en-1-one

Chemical compound data from PubChem database. IUPAC Name: 3-methoxy-2-(3-oxobutyl)-4,5-diphenylcyclopent-3-en-1-one. Molecular Formula: C22H22O3. Molecular Weight: 334.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Maryland (MD)

This report presents estimates for measures of substance use and mental health based on the combined 2010 and 2011 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for Maryland for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: major-depressive-episode, mental-health, samhsa, substance-use, suicidal-ideation
Organization: U.S. Department of Health & Human Services
Acetaminophen toxicity: suicidal vs accidental

Introduction
          Acetaminophen toxicity, which can lead to hepatotoxicity, is a burden on our health care system and contributes significantly to intensive care unit admissions and cost of hospitalization. The aim of our study was to determine the epidemiology of various types of acetaminophen poisoning and analyze their outcome compared with their admission characteristics.
        
        
          Methods
          We identified 93 consecutive patients, hospitalized for acetaminophen toxicity over a 52-month period from 1996 to 1999 in our urban county hospital. Retrospective case-control analysis was carried out using the data obtained from the medical records.
        
        
          Results
          Acetaminophen accounted for 7.5% of all cases of poisoning admitted during this period. Of the 93 patients, 80 were classified as suicidal and 13 had accidentally poisoned themselves in an attempt to relieve pain. The ratio of females to males was found to be 2:1. Of the 93 patients studied, 88 were admitted to the intensive care unit for initial 24–48 hours of monitoring. Peak acetaminophen levels were higher in the suicidal overdose group (mean 121.7 ± 97.0 mg/l vs 64.5 ± 61.8 mg/l, P < 0.05) than in the accidental group. In spite of this, peak aminotransferase levels >1000 IU/l were more often seen in the latter (39% vs 12%, P < 0.05). Hepatic coma and death were seen more often in the accidental overdose group (15% vs 0%, P < 0.05). Interestingly chronic alcohol abuse was also more frequent in the accidental overdose category (39% vs 18%, P = 0.05).
        
        
          Discussion
          Although the peak acetaminophen level in the suicidal group was significantly higher, cases of therapeutic misadventure had higher rates of morbidity and mortality. Peak acetaminophen levels correlate poorly with hepatic dysfunction, morbidity and mortality.
        
        
          Conclusion
          We recommend that the patients with suicidal acetaminophen overdose, without any concomitant poisoning, can safely managed on the medical floors.

Tags: acetaminophen-toxicity, drug-overdose, hepatotoxicity, nih, suicidal-ideation
Organization: U.S. Department of Health & Human Services
What you should know about PR3-ANCA: An introduction

Anti-neutrophil cytoplasmic antibodies (ANCA) have become important diagnostic markers of small vessel vasculitides characterized by focal necrotizing lesions of vessel walls and accumulation of lymphocytes and macrophages around the affected vessels. IgG class ANCA directed to proteinase 3 (PR3) of neutrophils and monocytes seem to be directly involved in the pathophysiology of vascular damage by causing excessive neutrophil activation and vessel wall destruction. PR3 and elastase are important players in the mechanisms of vascular necrosis. Methods of detecting ANCA have now been defined but are not uniformly used, even though clinical decisions heavily depend on correct ANCA results.

Tags: anca-vasculitis, autoimmune-disease, nih, proteinase-3, small-vessel-vasculitis
Organization: U.S. Department of Health & Human Services
San Francisco – SF Div: Drug-Related Emergency Department Visits, 2004-2011 - All Misuse and Abuse

Excel file with estimates, rates, relative standard errors, trends and confidence intervals for all drug-related emergency department (ED) visits involving drug misuse or abuse in the San Francisco division of the San Francisco metropolitan area, covering 2004-2011. Drug misuse/abuse visits include the use of illicit drugs, nonmedical use of pharmaceuticals, underage drinking and visits where alcohol was combined with another drug.

Tags: drug-related-ed, emergency-department, samhsa, san-francisco, substance-abuse
Organization: U.S. Department of Health & Human Services
2017 Uniform Reporting System (URS) Table for Illinois

This is the 2017 Uniform Reporting System (URS) Output Tables for Illinois. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-data, illinois, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Compound 525235: Ethanone, 1-[10-[3-(methylamino)propyl]-10H-phenothiazin-2-yl]-

Chemical compound data from PubChem database. IUPAC Name: 1-[10-[3-(methylamino)propyl]phenothiazin-2-yl]ethanone. Molecular Formula: C18H20N2OS. Molecular Weight: 312.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
New approaches to the modulation of inflammatory processes in airway disease models: ATS 2001, May 18-23, San Francisco

The 97th American Thoracic Society meeting proved to be an excellent meeting, providing a wealth of new information on inflammatory diseases of the airways. Once again there appeared to be an increased emphasis on chronic obstructive pulmonary disease (COPD) with most of the major drug companies concentrating a large part of their efforts in this field. An assessment of the new British Thoracic Society guidelines, which are designed to promote better management of COPD, was also presented at the meeting. Potential new treatments for inflammatory diseases of the airways including COPD were described, ranging from phase III trial data with GlaxoSmithKline's PDE4 inhibitor, Cilomilast (Ariflo®) to the development of AstraZeneca's novel dual dopamine D2-receptor/β2-adrenoreceptor agonist, Viozan™. Of particular interest was Byk Gulden's Ciclesonide, a new corticosteroid with equivalent efficacy to the market leaders but with an improved safety profile. The same company also presented data on their PDE4 inhibitor, Roflumilast, which is now in phase II/III. Bayer presented data on their PDE4 inhibitor, BAY 19-8004, in a smoking animal model and claimed greater anti-inflammatory efficacy than with a steroid. Asta Medica (now known as Elbion) also described a new potent PDE4 inhibitor, AWD 12-281, with anti-inflammatory activity. In the bronchodilator field, an analysis of data from a one-year trial with Boehringer Ingelheim's Tiotropium revealed a possible improvement in lung function in COPD patients; this needs to be confirmed in a specifically designed study. Inhibitors of p38 (c-Jun NH2-terminal kinase and syk kinase) were also discussed as anti-inflammatory agents with potential in the treatment of COPD and asthma. GlaxoSmithKline's p38 kinase inhibitor, SB 239063, appeared to be the most advanced of these with clinical data expected in two to three years. Lyn kinase was also discussed as a novel target for inflammatory airway diseases.

Tags: airway-inflammation, bronchodilators, copd-treatment, corticosteroids, nih
Organization: U.S. Department of Health & Human Services
Mutational analyses of the signals involved in the subcellular location of DSCR1

Background
          Down syndrome is the most frequent genetic disorder in humans. Rare cases involving partial trisomy of chromosome 21 allowed a small chromosomal region common to all carriers, called Down Syndrome Critical Region (DSCR), to be determined. The DSCR1 gene was identified in this region and is expressed preferentially in the brain, heart and skeletal muscle. Recent studies have shown that DSCR1 belongs to a family of proteins that binds and inhibits calcineurin, a serine-threonine phosphatase. The work reported on herein consisted of a study of the subcellular location of DSCR1 and DSCR1-mutated forms by fusion with a green fluorescent protein, using various cell lines, including human.
        
        
          Results
          The protein's location was preferentially nuclear, independently of the isoform, cell line and insertion in the GFP's N- or C-terminal. A segment in the C-terminal, which is important in the location of the protein, was identified by deletion. On the other hand, site-directed mutational analyses have indicated the involvement of some serine and threonine residues in this event.
        
        
          Conclusion
          In this paper, we discuss the identification of amino acids which can be important for subcellular location of DSCR1. The involvement of residues that are prone to phosphorylation suggests that the location and function of DSCR1 may be regulated by kinases and/or phosphatases.

Tags: calcineurin-inhibitors, down-syndrome, dscr1-gene, nih, protein-localization
Organization: U.S. Department of Health & Human Services
2018 N-MHSS State Profiles

These state profiles includes data from facilities that reported to N-MHSS for the survey reference date April 30, 2018. The N-MHSS collects data on the location, characteristics, services offered, and number of clients (collected every other year) in treatment at mental health treatment facilities (public and private) throughout the 50 states, the District of Columbia, U.S. territories, and other jurisdictions.

Tags: behavioral-health, client-characteristics, mental-health-services, samhsa, treatment-facilities
Organization: U.S. Department of Health & Human Services
Introduction to the National Youth in Transition Database Video Series

This six-part video series provides an overview of the National Youth in Transition Database (NYTD) and the NYTD Review, a federal review conducted by the Children’s Bureau to assess how states collect and report data on young people transitioning out of foster care. Using whiteboard animation, the videos cover the history and implementation of NYTD, NYTD data collection and reporting, an introduction to the NYTD Review, the system demonstration and survey methodology, the case record review, and the stakeholder interviews.

Part 1 of the “Introduction to NYTD” provides an overview, including background on why the database was developed and a timeline of the Children’s Bureau’s work with states to develop the NYTD.

Part 2 of the “Introduction to NYTD” discusses the process by which states collect and report NYTD data in accordance with federal regulation.

Part 3 provides an introduction to the NYTD Review, a process that evaluates how states collect and report data on young people in transition out of foster care.

Part 4 provides an overview of two elements of the onsite phase of the NYTD Review: the system demonstration and the survey methodology review.

Part 5 of the video series provides an overview of the case record review, an important element of the NYTD Review onsite phase.

Part 6, the final video of this series, provides an overview of the stakeholder interviews, including young people focus groups, an important element of the NYTD Review onsite phase.

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Metadata-only record linking to the original dataset. Open original dataset below.

Tags: assessment, care, foster, policy, reporting
Organization: U.S. Department of Health & Human Services
2009 NSDUH Detailed Tables

Results from the 2009 National Survey on Drug Use and Health: Mental Health Detailed Tables is a collection of tables presenting national estimates from the National Survey on Drug Use and Health (NSDUH). These tables present information on past year mental health measures and past year mental health service utilization for youths aged 12 to 17 and adults aged 18 or older. Adult tables include measures on any mental illness (AMI), serious mental illness (SMI), moderate mental illness (MMI), mild mental illness (LMI), mental health service utilization, suicidal thoughts and behaviors, major depressive episode (MDE), treatment for depression(among adults with MDE), and serious psychological distress (SPD). Youth tables include measures on mental health service utilization, MDE, and treatment for depression (among youths with MDE). Measures related to the co-occurrence of mental disorders with substance use or with substance use disorders also are presented for both adults and youths. Measures of these characteristics and behaviors are presented by a variety of demographic, geographic, and other variables.

Tags: major-depression, mental-health, samhsa, substance-use, suicidal-ideation
Organization: U.S. Department of Health & Human Services
2012 Uniform Reporting System (URS) Tables for Florida

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2012. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: florida-mental-health, mental-health-services, noms-measures, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
2016 Uniform Reporting System (URS) Table for Georgia

This is the 2016 Uniform Reporting System (URS) Output Tables for Georgia. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: georgia-mental-health, mental-health-services, national-outcome-measures, samhsa, substance-abuse-treatment
Organization: U.S. Department of Health & Human Services
Compound 525643: N,N-Dimethyl-N'-pentyl-p-chlorobenzamidine

Chemical compound data from PubChem database. IUPAC Name: 4-chloro-N,N-dimethyl-N'-pentylbenzenecarboximidamide. Molecular Formula: C14H21ClN2. Molecular Weight: 252.78. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Technical Bulletin #22 — Reporting Population & Data Extraction

This technical bulletin addresses how to extract data for the Out-of-Home Care and Adoption and Guardianship Assistance Files defined in AFCARS Technical Bulletin #21. Additionally, this document includes guidance on extracting corrected files (previously referred to as subsequent files) after the required AFCARS reporting periods. This technical bulletin was last revised on June 10, 2024.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: adoption, compliance, data, policy, reporting
Organization: U.S. Department of Health & Human Services