AndreaBozzo/ceres-open-data-index huggingface dataset:
TEDS 2011 Discharges

This is a 2011 Treatment Episode Data Set (TEDS) annual report showing discharges for people aged 12 and older from substance abuse treatment. The report provides information on treatment completion, length of stay in treatment, and demographic and substance abuse characteristics of discharges from alcohol or drug treatment in facilities that reported to individual state administra-tive data systems. The report represents forty-nine states and jurisdictions for discharges aged 12 and older occurring in 2011. Mississippi, Pennsylvania, and West Virginia submitted no data or incomplete data for 2011 and are excluded from this report.

Tags: addiction-treatment, samhsa, substance-abuse-treatment, teds-discharges, treatment-episode-data
Organization: U.S. Department of Health & Human Services
Specificity of T cells in synovial fluid: high frequencies of
		  CD8

CD8+ T cells dominate the lymphocyte population in
synovial fluid in chronic inflammatory arthritis. It is known that these
CD8+ T cells are often clonally or oligoclonally expanded, but their
specificity and their relevance to the pathogenesis of joint disease has
remained unclear. We found that as many as 15.5% of synovial CD8+ T
cells may be specific for a single epitope from an Epstein-Barr virus lytic
cycle protein. The virus-specific T cells within the joint showed increased
expression of markers of activation and differentiation compared with those in
the periphery, and retained their functional capacity to secrete
proinflammatory cytokines on stimulation. These activated, virus-specific
CD8+ T cells could therefore interact with synoviocytes, either by
cell-cell contact or by a cytokine network, and play a 'bystander'
role in the maintenance of inflammation in patients with arthritis.

Tags: cd8-t-cells, epstein-barr-virus, nih, rheumatoid-arthritis, synovial-fluid
Organization: U.S. Department of Health & Human Services
CCWIS Design, Software Repository, and CCWIS Options Presentation

This DSS presentation describes the Comprehensive Child Welfare Information System (CCWIS) Design Requirements, as defined by Federal Regulations 45 CFR 1355.53, the CCWIS Software Repository, as defined by Federal Regulations 45 CFR 1355.52(h), and CCWIS Options, as defined by Federal Regulations 45 CFR 1355.54.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: child, compliance, policy, regulation, social
Organization: U.S. Department of Health & Human Services
2012 Uniform Reporting System (URS) Tables for Puerto Rico

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2012. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, national-outcome-measures, puerto-rico, samhsa
Organization: U.S. Department of Health & Human Services
Response of regional brain glutamate transaminases of rat to aluminum in protein malnutrition

Background
          The mechanism of aluminum-induced neurotoxicity is not clear. The involvement of glutamate in the aluminium-induced neurocomplications has been suggested. Brain glutamate levels also found to be altered in protein malnutrition. Alterations in glutamate levels as well as glutamate-α-decarboxylase in different regions of rat brain has been reported in response to aluminum exposure. Thus the study of glutamate metabolising enzymes in different brain regions of rats maintained on either normal or restricted protein diet may be of importance for understanding the neurotoxicity properties of aluminium.
        
        
          Results
          Dietary protein restrictions does not have an significant impact on regional aluminum content of the brain. The interaction of aluminum intoxication and protein restriction is significant in the thalamic area and the midbrain-hippocampal region in cases of glutamate oxaloacetate transaminase. In the case of gluatmate pyruvate transaminase, this interaction is significant only in thalamic area.
        
        
          Conclusion
          The metabolism of amino acids, as indicated by activities of specific transaminases, of brain is altered in response to aluminum exposure. These alterations are region specific and are dependent on dietary protein intake or manipulation of the brain amino acid homeostasis.

Tags: aluminum-neurotoxicity, glutamate-transaminases, nih, protein-malnutrition, rat-brain-regions
Organization: U.S. Department of Health & Human Services
2013 CMHS Uniform Reporting System (URS) Table for Northern Mariana Islands

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Tables for Northern Mariana Islands for 2013. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program.  State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, noms-measures, northern-mariana-islands, samhsa
Organization: U.S. Department of Health & Human Services
Foster Care: A Path to Reunification – Part 1

This Child Welfare Information Gateway Podcast is available on Apple Podcasts
  
  

, GooglePlay
  
  

, Spotify
  
  

, Stitcher
  
  

, SoundCloud
  
  

, and the Child Welfare Information Gateway
  
  

 website. Subscribe to receive new episodes as they are released.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: care, child, foster, policy, reunification
Organization: U.S. Department of Health & Human Services
Subjective response to antipsychotic treatment and compliance in schizophrenia. A naturalistic study comparing olanzapine, risperidone and haloperidol (EFESO Study)

Background
          In order to compare the effectiveness of different antipsychotic drugs in the treatment of schizophrenia it is very important to evaluate subjective response and compliance in patient cohorts treated according to routine clinical practice.
        
        
          Method
          Outpatients with schizophrenia entered this prospective, naturalistic study when they received a new prescription for an antipsychotic drug. Treatment assignment was based on purely clinical criteria, as the study did not include any experimental intervention. Patients treated with olanzapine, risperidone or haloperidol were included in the analysis. Subjective response was measured using the 10-item version of the Drug Attitude Inventory (DAI-10), and treatment compliance was measured using a physician-rated 4 point categorical scale.
        
        
          Results
          A total of 2128 patients initiated treatment (as monotherapy) with olanzapine, 417 with risperidone, and 112 with haloperidol. Olanzapine-treated patients had significantly higher DAI-10 scores and significantly better treatment compliance compared to both risperidone- and haloperidol-treated patients. Risperidone-treated patients had a significantly higher DAI-10 score compared to haloperidol-treated patients.
        
        
          Conclusion
          Subjective response and compliance were superior in olanzapine-treated patients, compared to patients treated with risperidone and haloperidol, in routine clinical practice. Differences in subjective response were explained largely, but not completely, by differences in incidence of EPS.

Tags: antipsychotic-drugs, drug-attitude-inventory, nih, schizophrenia-treatment, treatment-compliance
Organization: U.S. Department of Health & Human Services
Severe hypomagnesaemia with tetany following ESHAP protocol

Background
          One patient with B-cell Non-Hodgkin's Lymphoma developed severe hypomagnesaemia and tetany 15 days after the first course of treatment with ESHAP protocol. This prompted a careful look at the incidence and severity of hypomagnesaemia during treatment with this combination chemotherapy.
        
        
          Method
          This patient and two further patients having the same treatment were monitored for hypomagnesaemia throughout their treatment period.
        
        
          Result
          All three patients developed significant hypomagnesaemia requiring intravenous magnesium infusion in the second and third weeks after treatment though not after every course of chemotherapy.
        
        
          Conclusions
          ESHAP protocol is often associated with significant hypomagnesaemia two to three weeks after treatment. Therefore, serum magnesium level should be monitored throughout the treatment period.

Tags: eshap-protocol, hypomagnesemia, nih, non-hodgkins-lymphoma, tetany
Organization: U.S. Department of Health & Human Services
New York City – 5 Boros: Drug-Related Emergency Department Visits, 2004-2011 - Adverse Reactions

Excel file with estimates, rates, relative standard errors, trends and confidence intervals, covering 2004-2011 for emergency department visits involving adverse reactions in New York City (5 boroughs). It includes ED visits in which an adverse health consequence (e.g., side effects or an allergic reaction) resulted when taking prescription drugs, over-the-counter medications, or dietary supplements as prescribed or recommended.  This analytic category does not include drug misuse or abuse.File includes data for over 500 drugs, including illicit drugs, prescription and over-the-counter medications, dietary supplements, inhalants and alcohol.  Includes total visits, gender, age group, race/ethnicity, outcome of visit, drug combinations, number of drugs involved in visit, drug frequency, and drugs confirmed by toxicology.Additional detail is provided for illicit drugs, psychotherapeutic drugs, central nervous system (CNS) drugs, respiratory drugs and cardiovascular drugs.

Tags: adverse-drug-reactions, emergency-department-visits, nyc-drug-surveillance, prescription-drug-side-effects, samhsa
Organization: U.S. Department of Health & Human Services
Montana (MT)

This report uses 2008 to 2010 National Survey on Drug Use and Health (NSDUH) to assess past year alcohol use disorder and illicit drug use disorder among persons aged 12 or older for Montana overall and for substate regions within Montana. Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE).

Tags: mental-health-indicators, montana, nsduh-data, samhsa, substance-use-disorder
Organization: U.S. Department of Health & Human Services
Functional group interactions of a 5-HT

Background
          Lerisetron, a competitive serotonin type 3 receptor (5-HT3R) antagonist, contains five functional groups capable of interacting with amino acids in the 5-HT3R binding site. Site directed mutagenesis studies of the 5-HT3AR have revealed several amino acids that are thought to form part of the binding domain of this receptor. The specific functional groups on the ligand that interact with these amino acids are, however, unknown. Using synthetic analogs of lerisetron as molecular probes in combination with site directed mutagenesis, we have identified some of these interactions and have proposed a model of the lerisetron binding site.
        
        
          Results
          Two analogs of lerisetron were synthesized to probe 5-HT3R functional group interactions with this compound. Analog 1 lacks the N1 benzyl group of lerisetron and analog 2 contains oxygen in place of the distal piperazine nitrogen. Both analogs show significantly decreased binding affinity to wildtype 5-HT3ASRs. Mutations at W89, R91, Y142 and Y152 produced significant decreases in binding compared to wildtype receptors. Binding affinities of analogs 1 and 2 were altered only by mutations at W89, and Y152.
        
        
          Conclusions
          Based on the data obtained for lerisetron and analogs 1 and 2, we have proposed a tentative model of the lerisetron binding pocket of the 5-HT3ASR. According to this model, The N-benzyl group interacts in a weak interaction with R91 while the benzimidazole group interacts with W89. Our data support an interaction of the distal amino nitrogen with Y142 and Y152.

Tags: 5-ht3-receptor, 5-ht3r-antagonist, lerisetron, nih, serotonin-antagonist
Organization: U.S. Department of Health & Human Services
Complete genome sequence of a novel extrachromosomal virus-like element identified in planarian

Background
          Freshwater planarians are widely used as models for investigation of pattern formation and studies on genetic variation in populations. Despite extensive information on the biology and genetics of planaria, the occurrence and distribution of viruses in these animals remains an unexplored area of research.
        
        
          Results
          Using a combination of Suppression Subtractive Hybridization (SSH) and Mirror Orientation Selection (MOS), we compared the genomes of two strains of freshwater planarian, Girardia tigrina. The novel extrachromosomal DNA-containing virus-like element denoted PEVE (Planarian Extrachromosomal Virus-like Element) was identified in one planarian strain. The PEVE genome (about 7.5 kb) consists of two unique regions (Ul and Us) flanked by inverted repeats. Sequence analyses reveal that PEVE comprises two helicase-like sequences in the genome, of which the first is a homolog of a circoviral replication initiator protein (Rep), and the second is similar to the papillomavirus E1 helicase domain. PEVE genome exists in at least two variant forms with different arrangements of single-stranded and double-stranded DNA stretches that correspond to the Us and Ul regions. Using PCR analysis and whole-mount in situ hybridization, we characterized PEVE distribution and expression in the planarian body.
        
        
          Conclusions
          PEVE is the first viral element identified in free-living flatworms. This element differs from all known viruses and viral elements, and comprises two potential helicases that are homologous to proteins from distant viral phyla. PEVE is unevenly distributed in the worm body, and is detected in specific parenchyma cells.

Tags: extrachromosomal-element, genome-sequence, girardia-tigrina, nih, planarian-virus
Organization: U.S. Department of Health & Human Services
Debate: Do all patients with heart failure require implantable defibrillators to prevent sudden death?

Sudden death is a major cause of mortality in patients with ventricular dysfunction. The highest risk occurs among patients with less severe functional impairment. Current methods of risk stratification are inadequate, and a rational therapy for prevention of sudden death is not available. The implantable cardioverter-defibrillator (ICD) has proven to be more effective than drugs in reducing sudden-death risk in some subsets of patients. Empiric ICD therapy, targeting the general population with mild to moderate heart failure, will maximize the impact of such a strategy to prevent sudden death and improve long-term survival.

Tags: heart-failure, implantable-defibrillators, nih, sudden-cardiac-death, ventricular-dysfunction
Organization: U.S. Department of Health & Human Services
PSYCKES Antipsychotic Polypharmacy Quality Indicators: Beginning 2012

The PSYCKES antipsychotic polypharmacy measure data set provides a count of how many New York State Medicaid enrollees are eligible to be included in the measure (individuals prescribed any antipsychotic medication), the count of how many enrollees meet criteria for the flag (individuals prescribed two or more [2AP] or three or more [3AP] antipsychotic medications concurrently for more than 90 days), and the percentage of enrollees flagged.

Tags: mental-health, planning, psychiatric, quality-improvement
Organization: State of New York
Research Article: BMC Ecology

Background
          In spite of very low nutrient concentrations in its vicinity – both column and pore waters-, the Posidonia oceanica of the Revellata Bay displays high biomass and productivity. We measured the nutrient fluxes from the sediment into the water enclosed among the leaf shoots ("canopy water") to determine if it is possible source of nutrients for P. oceanica leaves.
        
        
          Results
          During the summer, the canopy water appears to act as a nutrient reservoir for the plant. During that period, the canopy water layer displays both a temperature 0.5°C cooler than the upper water column, and a much higher nutrient content, as shown in this work using a very simple original technique permitting to sample water with a minimal disturbance of the water column's vertical structure.
          Despite low nutrient concentrations in pore water, mean net fluxes were measured from the sediment to the canopy water. These fluxes are sufficient to provide 20% of the mean daily nitrogen and phosphorus requirement of the P. oceanica shoots.
        
        
          Conclusion
          An internal cycling of nutrients from P. oceanica senescent leaves was previously noted as an efficient strategy to help face low nutrient availability. The present study points out a second strategy which consists in holding back, in the canopy, the nutrients released at the water-sediment interface. This process occurs when long leaves, during poor nutrient periods in the water column, providing, to P. oceanica, the possibility to develop, high biomass, high chlorophyll quantities in low nutrient environment (a Low Nutrients High Chlorophyll system).

Tags: ecology, nih, nutrient-flux, posidonia-oceanica, seagrass-ecosystem
Organization: U.S. Department of Health & Human Services
Compound 527268: Carvacryl ethyl ether

Chemical compound data from PubChem database. IUPAC Name: 2-ethoxy-1-methyl-4-propan-2-ylbenzene. Molecular Formula: C12H18O. Molecular Weight: 178.27. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2013 CMHS Uniform Reporting System (URS) Tables for Maine

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Tables for Maine for 2013. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program.  State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, maine, mental-health-services, samhsa, urs-data
Organization: U.S. Department of Health & Human Services
Types of inter-atomic interactions at the MHC-peptide interface: Identifying commonality from accumulated data

Background
          Quantitative information on the types of inter-atomic interactions at the MHC-peptide interface will provide insights to backbone/sidechain atom preference during binding. Qualitative descriptions of such interactions in each complex have been documented by protein crystallographers. However, no comprehensive report is available to account for the common types of inter-atomic interactions in a set of MHC-peptide complexes characterized by variation in MHC allele and peptide sequence. The available x-ray crystallography data for these complexes in the Protein Databank (PDB) provides an opportunity to identify the prevalent types of such interactions at the binding interface.
        
        
          Results
          We calculated the percentage distributions of four types of interactions at varying inter-atomic distances. The mean percentage distribution for these interactions and their standard deviation about the mean distribution is presented. The prevalence of SS and SB interactions at the MHC-peptide interface is shown in this study. SB is clearly dominant at an inter-atomic distance of 3Å.
        
        
          Conclusion
          The prevalently dominant SB interactions at the interface suggest the importance of peptide backbone conformation during MHC-peptide binding. Currently, available algorithms are developed for protein sidechain prediction upon fixed backbone template. This study shows the preference of backbone atoms in MHC-peptide binding and hence emphasizes the need for accurate peptide backbone prediction in quantitative MHC-peptide binding calculations.

Tags: allele-variation, inter-atomic-interactions, mhc-peptide-binding, nih, protein-crystallography
Organization: U.S. Department of Health & Human Services
2012 State Profile - South Dakota

This is a National Survey of Substance Abuse Treatment Services (N-SSATS) annual report showing the state profile for South Dakota in 2012. N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 States, the District of Columbia, and other U.S. jurisdictions.

Tags: n-ssats, samhsa, south-dakota, substance-abuse-treatment, treatment-facilities
Organization: U.S. Department of Health & Human Services
Solar Power Arrays at Parks Installed: Beginning 2012

This dataset includes all solar photovoltaic projects installed at State Parks or Historic Sites since the first project was installed in 2012. It includes the year of completion, Park region, facility name, project title, whether the project is grid-connected or off-grid, system capacity in kilowatts (1,000 watts), and the utility company for that facility.

Tags: energy, nys-parks, photovoltaic, solar-power
Organization: State of New York
August 2025 Tracy Arm, USA Images

On Sunday, August 10th, 2025, at 13:26 UTC, a landslide occurred in Tracy Arm, Alaska, about 80 miles (130 km) south-southeast of Juneau. The landslide generated a tsunami in the fjord where a runup height reached an estimated 470 m on the opposite shore and was also recorded far from the source on a NOAA coastal tide gauge in Juneau. The National Tsunami Warning Center reported that the maximum tsunami wave height at the gauge was 36 cm (approximately 14 in) above the tide, and that the waves continued for hours.

Tags: alaska, continent, doc/noaa/nesdis/ncei, doc/noaa/nesdis/ngdc, earth science, erosion/sedimentation, human dimensions, icsu-wds, infrastructure, international council for science - world data system, land surface, landslides, national centers for environmental information, national geophysical data center, natural hazards, nesdis, noaa, noaa onestop project, north america, ocean waves, oceans, seiches, tracy arm, tsunamis, u.s. department of commerce, united states of america
Organization: National Oceanic and Atmospheric Administration, Department of Commerce