AndreaBozzo/ceres-open-data-index huggingface dataset:
Genetic modification of glaucoma associated phenotypes between AKXD-28/Ty and DBA/2J mice

Background
          Glaucoma is a common disease but its molecular etiology is poorly understood. It involves retinal ganglion cell death and optic nerve damage that is often associated with elevated intraocular pressure. Identifying genes that modify glaucoma associated phenotypes is likely to provide insights to mechanisms of glaucoma. We previously reported glaucoma in DBA/2J mice caused by recessive alleles at two loci, isa and ipd, that cause iris stromal atrophy and iris pigment dispersion, respectively. A approach for identifying modifier genes is to study the effects of specific mutations in different mouse strains. When the phenotypic effect of a mutation is modified upon its introduction into a new strain, crosses between the parental strains can be used to identify modifier genes. The purpose of this study was to determine if the effects of the DBA/2J derived isa and ipd loci are modified in strain AKXD-28/Ty.
        
        
          Results
          AKXD-28/Ty mice develop glaucoma characterized by intraocular pressure elevation, retinal ganglion loss, and optic nerve excavation. In AKXD-28/Ty, isa causes an iris stromal atrophy phenotype as in DBA/2J. However, the iris pigment dispersion phenotype associated with ipd in DBA/2J does not occur in AKXD-28/Ty. Additionally, a greater severity and speed of retinal and optic nerve damage following intraocular pressure elevation in AKXD-28/Ty compared to DBA/2J mice suggests that AKXD-28/Ty is more susceptible to pressure-induced cell death.
        
        
          Conclusions
          The consequences of the ipd and isa mutations are modified in the AKXD-28/Ty background. These strains provide a resource for the identification of modifier genes that modulate pigment dispersion and susceptibility to pressure-induced cell death.

Tags: glaucoma-genetics, intraocular-pressure, mouse-model, nih, retinal-ganglion-cell
Organization: U.S. Department of Health & Human Services
Compound 530261: 1,3,5-tris-(Hydroxymethyl) benzene, tris-TMS

Chemical compound data from PubChem database. IUPAC Name: [3,5-bis(trimethylsilyloxymethyl)phenyl]methoxy-trimethylsilane. Molecular Formula: C18H36O3Si3. Molecular Weight: 384.7. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 528558: Pentadecane, 5-propyl

Chemical compound data from PubChem database. IUPAC Name: 5-propylpentadecane. Molecular Formula: C18H38. Molecular Weight: 254.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Signal and noise in bridging PCR

Background
          In a variant of the standard PCR reaction termed bridging, or jumping, PCR the primer-bound sequences are originally on separate template molecules. Bridging can occur if, and only if, the templates contain a region of sequence similarity. A 3' end of synthesis in one round of synthesis that terminates in this region of similarity can prime on the other. In principle, Bridging PCR (BPCR) can detect a subpopulation of one template that terminates synthesis in the region of sequence shared by the other template. This study considers the sensitivity and noise of BPCR as a quantitative assay for backbone interruptions. Bridging synthesis is also important to some methods for computing with DNA.
        
        
          Results
          In this study, BPCR was tested over a 328 base pair segment of the E. coli lac operon and a signal to noise ratio (S/N) of approximately 10 was obtained under normal PCR conditions with Taq polymerase. With special precautions in the case of Taq or by using the Stoffel fragment the S/N was improved to 100, i.e. 1 part of cut input DNA yielded the same output as 100 parts of intact input DNA.
        
        
          Conclusions
          In the E. coli lac operator region studied here, depending on details of protocol, between 3 and 30% per kilobase of final PCR product resulted from bridging. Other systems are expected to differ in the proportion of product that is bridged consequent to PCR protocol and the sequence analyzed. In many cases physical bridging during PCR will have no informational consequence because the bridged templates are of identical sequence, but in a number of special cases bridging creates, or, destroys, information.

Tags: bridging-pcr, dna-synthesis, nih, polymerase-chain-reaction, sequence-similarity
Organization: U.S. Department of Health & Human Services
2019 Uniform Reporting System (URS) Table for Connecticut

These are the 2019 Uniform Reporting System (URS) Output Tables for Connecticut. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-data, connecticut-urs, mental-health-services, noms-measures, samhsa
Organization: U.S. Department of Health & Human Services
Compound 530111: 5,6-Dimethyladenine, TMS

Chemical compound data from PubChem database. IUPAC Name: 7,8-dimethyl-N-trimethylsilylpurin-6-amine. Molecular Formula: C10H17N5Si. Molecular Weight: 235.36. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Patent AT-E399758-T1: [Translated] DERIVATIVES OF 1-PHENYLALKANECARBONIC ACIDS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES

The present invention concerns novel derivatives of 1-phenylalkanecarboxylic acids, pharmaceutical compositions thereof, a process for their preparation and their use for the treatment and/or prevention of neurodegenerative diseases such as Alzheimer's disease.

Tags: chemistry, innovation, patent, pubchem, research
Organization: U.S. Department of Health & Human Services
2016 Uniform Reporting System (URS) Table for Arkansas

This is the 2016 Uniform Reporting System (URS) Output Tables for Arkansas. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: arkansas-health, mental-health-services, national-outcome-measures, samhsa, substance-abuse-treatment
Organization: U.S. Department of Health & Human Services
Compound 528076: Quinoline, 3-butyl-2-methyl

Chemical compound data from PubChem database. IUPAC Name: 3-butyl-2-methylquinoline. Molecular Formula: C14H17N. Molecular Weight: 199.29. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 528559: Tetracosane, 6-methyl

Chemical compound data from PubChem database. IUPAC Name: 6-methyltetracosane. Molecular Formula: C25H52. Molecular Weight: 352.7. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2019-2020 National Survey on Drug Use and Health: Model-Based Prevalence Estimates (50 States and the District of Columbia)

State estimates for these years are no longer available due to methodological concerns with combining 2019 and 2020 data. We apologize for any inconvenience or confusion this may causeBecause of the COVID-19 pandemic, most respondents answered the survey via the web in Quarter 4 of 2020, even though all responses in Quarter 1 were from in-person interviews. It is known that people may respond to the survey differently while taking it online, thus introducing what is called a mode effect.When the state estimates were released, it was assumed that the mode effect was similar for different groups of people. However, later analyses have shown that this assumption should not be made. Because of these analyses, along with concerns about the rapid societal changes in 2020, it was determined that averages across the two years could be misleading.For more detail on this decision, see the 2019-2020state data page.

Tags: drug-use, mental-health, samhsa, state-prevalence, substance-abuse
Organization: U.S. Department of Health & Human Services
2016 Uniform Reporting System (URS) Table for Wisconsin

This is the 2016 Uniform Reporting System (URS) Output Tables for Wisconsin. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-data, community-mental-health, mental-health-services, outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Title IV-E Prevention Program Data Submission Fall 2022 Webinar

On November 1, 2022, the Children’s Bureau hosted a webinar on Title IV-E Program Data Submission which included a review of the data quality rules, provided clarity on some of the data elements, and reviewed the commonly observed errors in the first submission. The Webinar and Presentation slides may be accessed through the links below.

Descriptive Audio Version

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: child, data, policy, prevention, reporting
Organization: U.S. Department of Health & Human Services
Compound 526782: 8-Hydroxy-nonadecanoic, methyl ester, tBDMS ether

Chemical compound data from PubChem database. IUPAC Name: methyl 8-[tert-butyl(dimethyl)silyl]oxynonadecanoate. Molecular Formula: C26H54O3Si. Molecular Weight: 442.8. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2018 Uniform Reporting System (URS) Table for Oregon

This is the 2018 Uniform Reporting System (URS) Output Tables for Oregon. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-data, mental-health-services, noms-measures, oregon-urs-data, samhsa
Organization: U.S. Department of Health & Human Services
Compound 530587: 2-Chlorobenzoic acid, tridecyl ester

Chemical compound data from PubChem database. IUPAC Name: tridecyl 2-chlorobenzoate. Molecular Formula: C20H31ClO2. Molecular Weight: 338.9. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
The regulation of protein synthesis and translation factors by CD3 and CD28 in human primary T lymphocytes

Background
          Activation of human resting T lymphocytes results in an immediate increase in protein synthesis. The increase in protein synthesis after 16–24 h has been linked to the increased protein levels of translation initiation factors. However, the regulation of protein synthesis during the early onset of T cell activation has not been studied in great detail. We studied the regulation of protein synthesis after 1 h of activation using αCD3 antibody to stimulate the T cell receptor and αCD28 antibody to provide the co-stimulus.
        
        
          Results
          Activation of the T cells with both antibodies led to a sustained increase in the rate of protein synthesis. The activities and/or phosphorylation states of several translation factors were studied during the first hour of stimulation with αCD3 and αCD28 to explore the mechanism underlying the activation of protein synthesis. The initial increase in protein synthesis was accompanied by activation of the guanine nucleotide exchange factor, eukaryotic initiation factor (eIF) 2B, and of p70 S6 kinase and by dephosphorylation of eukaryotic elongation factor (eEF) 2. Similar signal transduction pathways, as assessed using signal transduction inhibitors, are involved in the regulation of protein synthesis, eIF2B activity and p70 S6 kinase activity. A new finding was that the p38 MAPK α/β pathway was involved in the regulation of overall protein synthesis in primary T cells. Unexpectedly, no changes were detected in the phosphorylation state of the cap-binding protein eIF4E and the eIF4E-binding protein 4E-BP1, or the formation of the cap-binding complex eIF4F.
        
        
          Conclusions
          Both eIF2B and p70 S6 kinase play important roles in the regulation of protein synthesis during the early onset of T cell activation.

Tags: cd3-cd28-stimulation, nih, protein-synthesis, t-lymphocyte-activation, translation-factors
Organization: U.S. Department of Health & Human Services
Analytics

Analytics HealthData.gov is the home of HHS Open Data, providing researchers, policymakers, and the public with access to valuable information that drives innovation, transparency, and informed decision making. This dashboard provides at-a-glance insights into: How users are engaging with HHS data
What categories of data and data resources are available
How data engagement has evolved over time.

Tags: analytics-dashboard
Organization: U.S. Department of Health & Human Services
Transcriptional regulation of collagenase (MMP-1, MMP-13) genes in arthritis: integration of complex signaling pathways for the recruitment of gene-specific transcription factors

Matrix metalloproteinase (MMP)-1, MMP-8 and MMP-13 are interstitial collagenases that degrade type II collagen in cartilage; this is a committed step in the progression of rheumatoid arthritis and osteoarthritis. Of these enzymes, the expression of MMP-1 and MMP-13 is substantially increased in response to IL-1 and tumor necrosis factor-α, and elevated levels of these collagenases are observed in arthritic tissues. Therefore, cytokine-mediated MMP-1 and MMP-13 gene regulation is an important issue in arthritis research. In this review, we discuss current models of MMP-1 and MMP-13 transcriptional regulation, with a focus on signaling intermediates and transcription factors that may be future targets for the development of new arthritis drugs.

Tags: arthritis-genes, collagenase-regulation, mmp-1-mmp-13, nih, rheumatoid-arthritis
Organization: U.S. Department of Health & Human Services
Prior Relationship of Adoptive Parent(s) to Child 10/1/2000 - 9/30/2001

This report provides state-specific data from fiscal year 2001 about the prior relationships of the adoptive parents to the children who were adopted through public agencies.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: adoption, child, data, fiscal, policy
Organization: U.S. Department of Health & Human Services
Compound 527445: 3-Mercaptohexanal

Chemical compound data from PubChem database. IUPAC Name: 3-sulfanylhexanal. Molecular Formula: C6H12OS. Molecular Weight: 132.23. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Publications Using SAMHSA Data2012 Uniform Reporting System (URS) Tables for Mississippi

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2012. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: mental-health-services, mississippi-mental-health, national-outcome-measures, samhsa, urs-data
Organization: U.S. Department of Health & Human Services
Compound 527884: 1-Chloropropyl acetate

Chemical compound data from PubChem database. IUPAC Name: 1-chloropropyl acetate. Molecular Formula: C5H9ClO2. Molecular Weight: 136.58. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Patent AT-E399887-T1: [Translated] HIGHER DENSITY NON-TOXIC COMPOSITES WHICH CONTAIN TUNGSTEN, OTHER METAL AND POLYMER POWDER

Tungsten/polymer composites comprising tungsten powder, another metal powder having a high packing density, and organic binder have high density, good processibility and good malleability. Such composites are useful as lead replacements, particularly in the manufacture of shot.

Tags: chemistry, innovation, patent, pubchem, research
Organization: U.S. Department of Health & Human Services
Compound 529522: 1-Bis(tert-butyldimethylsilyloxy)phosphoryl-N-(tert-butyldimethylsilyl)methanamine

Chemical compound data from PubChem database. IUPAC Name: 1-bis[[tert-butyl(dimethyl)silyl]oxy]phosphoryl-N-[tert-butyl(dimethyl)silyl]methanamine. Molecular Formula: C19H48NO3PSi3. Molecular Weight: 453.8. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 527031: 3,6-Dimethylpyridazine

Chemical compound data from PubChem database. IUPAC Name: 3,6-dimethylpyridazine. Molecular Formula: C6H8N2. Molecular Weight: 108.14. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Patent AT-E400737-T1: [Translated] STARTING DEVICE FOR AN INTERNAL COMBUSTION ENGINE

The invention relates to a starter device (160) for an internal combustion engine, comprising a starter motor (140) and a switching control device for controlling the starter motor (140). The latter comprises a power switching module (165,170, 175, 180) connecting the starter motor (140) to a voltage source (130). The switching control device also comprises a control electronics system (195) used to control the power switching module (165,170, 175, 180), and an actuating device (135) used to activate the control electronics system (195). The control electronics system (195) is configured in such a way that it can be operated with a supply voltage which is less than 5V, thereby ensuring safe operation of the starter device even if the supply voltage falls off in the wake of the starting process.

Tags: chemistry, innovation, patent, pubchem, research
Organization: U.S. Department of Health & Human Services
Patent AT-E399648-T1: [Translated] IMAGE RECORDING DEVICE

An image recording apparatus includes: a first guide member having a first sliding surface; a second guide member having another first sliding surface; and a carriage being supported by the first sliding surfaces of the first and second guide members. The carriage includes first sliding convex parts protruding from a lower surface side thereof and coming in contact with the first sliding surfaces of the first and second guide members, and a coming-out preventing pawl disposed to hold at least one of the first and second guide members in cooperation with the first sliding convex part. At least one of the first and second guide members includes a notch part at a specified position, and the carriage is detachable from the first and second guide members by causing the coming-out preventing pawl to pass through the notch part. <IMAGE>

Tags: chemistry, innovation, patent, pubchem, research
Organization: U.S. Department of Health & Human Services
Compound 527462: Methyldocosene

Chemical compound data from PubChem database. IUPAC Name: tricos-2-ene. Molecular Formula: C23H46. Molecular Weight: 322.6. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2015 CMHS Uniform Reporting System (URS) Table for Republic of Marshall Islands

2015 Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for Republic of Marshall Islands. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, marshall-islands, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Compound 528214: Benzoic acid, 2-hydroxy-6-methyl-3-(1,1-dimethylethyl), DTBS

Chemical compound data from PubChem database. IUPAC Name: 2,2,8-tritert-butyl-5-methyl-1,3,2-benzodioxasilin-4-one. Molecular Formula: C20H32O3Si. Molecular Weight: 348.6. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 529031: Oxazole, 4-ethyl-5-methyl

Chemical compound data from PubChem database. IUPAC Name: 4-ethyl-5-methyl-1,3-oxazole. Molecular Formula: C6H9NO. Molecular Weight: 111.14. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services