AndreaBozzo/ceres-open-data-index huggingface dataset:
Envelope structure of

Background
          Many bacteria swim by rotating helical flagellar filaments [1]. Waterbury et al. [15] discovered an exception, strains of the cyanobacterium Synechococcus that swim without flagella or visible changes in shape. Other species of cyanobacteria glide on surfaces [2,7]. The hypothesis that Synechococcus might swim using traveling surface waves [6,13] prompted this investigation.
        
        
          Results
          Using quick-freeze electron microscopy, we have identified a crystalline surface layer that encloses the outer membrane of the motile strain Synechococcus sp. WH8113, the components of which are arranged in a rhomboid lattice. Spicules emerge in profusion from the layer and extend up to 150 nm into the surrounding fluid. These spicules also send extensions inwards to the inner cell membrane where motility is powered by an ion-motive force [17].
        
        
          Conclusion
          The envelope structure of Synechococcus sp. WH8113 provides new constraints on its motile mechanism. The spicules are well positioned to transduce energy at the cell membrane into mechanical work at the cell surface. One model is that an unidentified motor embedded in the cell membrane utilizes the spicules as oars to generate a traveling wave external to the surface layer in the manner of ciliated eukaryotes.

Tags: bacterial-envelope, cyanobacteria-motility, electron-microscopy, nih, synechococcus-structure
Organization: U.S. Department of Health & Human Services
Compound 525167: Hexaethylene glycol, monoallyl ether, acetate

Chemical compound data from PubChem database. IUPAC Name: 2-[2-[2-[2-[2-(2-prop-2-enoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethyl acetate. Molecular Formula: C17H32O8. Molecular Weight: 364.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 529833: (Hexacosyloxy)trimethylsilane

Chemical compound data from PubChem database. IUPAC Name: hexacosoxy(trimethyl)silane. Molecular Formula: C29H62OSi. Molecular Weight: 454.9. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2023 Uniform Reporting System (URS) Table For Vermont

This is the 2023 Uniform Reporting System (URS) Output Tables for Vermont. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-data, mental-health-services, national-outcome-measures, samhsa, vermont
Organization: U.S. Department of Health & Human Services
Compound 529192: 1-tert-Butyl-N-(2-(tert-butyldimethylsilyloxy)ethyl)-1,1-dimethylsilanamine

Chemical compound data from PubChem database. IUPAC Name: N-[tert-butyl(dimethyl)silyl]-2-[tert-butyl(dimethyl)silyl]oxyethanamine. Molecular Formula: C14H35NOSi2. Molecular Weight: 289.6. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Miami - Fort Lauderdale Div: Drug-Related Emergency Department Visits, 2008-2011 - Nonmedical Use of Pharmaceuticals

Excel file with estimates, rates, relative standard errors, trends and confidence intervals for all drug-related emergency department (ED) visits involving the nonmedical use of pharmaceuticals (prescription and over-the-counter medications and dietary supplements) for the Miami metropolitan area, Fort Lauderdale division, covering 2008-2011.  Nonmedical use includes patients who took a higher than prescribed or recommended dose of their own medication, patients who took a pharmaceutical prescribed for another person, malicious poisoning of the patient by another individual, and documented substance abuse involving pharmaceuticals

Tags: drug-related-visits, emergency-department, miami-fort-lauderdale, pharmaceutical-misuse, samhsa
Organization: U.S. Department of Health & Human Services
Patent AT-E399597-T1: [Translated] ATOMIZER AND FILTER THEREOF

A sprayer, which in one embodiment, is a hand held ergonomic sprayer is disclosed herein. The sprayer may include: a housing through which water flows; a handle for gripping by a user, which is joined to the housing; at least one spray nozzle operatively connected to the housing; and, a connection for a hose, the connection being joined to the housing. In one non-limiting embodiment, when the sprayer has one end of a water-filled hose connected thereto, the combination of the sprayer and suspended portion of the hose has a combined center of gravity that passes through the axis of the sprayer handle. The sprayers described herein may also have other features, and provide other benefits that do not require the sprayers to have an ergonomic design.

Tags: chemistry, innovation, patent, pubchem, research
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Arkansas, 2015

This is a behavioral health report for the state of Arkansa. The report utilizes data from the National Survey on Drug Use and Health (NSDUH), and the Uniform Reporting System. The topics addressed in the report include youth substance use, youth mental health and treatment, mental health and treatment, substance use and substance use treatment.

Tags: arkansas-behavioral-health, mental-health-treatment, nsduh-data, samhsa, youth-substance-use
Organization: U.S. Department of Health & Human Services
Compound 525795: N-(3-methylphenyl)-N'-(3-chlorophenyl)formamidine

Chemical compound data from PubChem database. IUPAC Name: N'-(3-chlorophenyl)-N-(3-methylphenyl)methanimidamide. Molecular Formula: C14H13ClN2. Molecular Weight: 244.72. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Patent AT-E400804-T1: [Translated] METHOD FOR ANALYZING A SCATTERING SAMPLE BY TIME-RESOLVED MEASUREMENT

A method for analyzing a diffusing sample comprises steps of: a) illuminating the sample with temporally coherent and wavelength-modulated incident light beam; b) producing a succession of interference signals with the diffuse light; c) combining each interference signal with a reference signal (Ref(t,tau<SUB>0</SUB>)) generating a time port; d) extracting the continuous component of each signal characteristic of the predetermined delay (tau<SUB>0</SUB>) derived form c); applying a nonlinear function on each of the continuous components of the signals characterizing the predetermined delay (tau<SUB>0</SUB>); and f) averaging each of the images, with the non-linear function, of the continuous components of the signals characterizing the predetermined delay (tau<SUB>0</SUB>). The invention is useful for observing organs of the human body.

Tags: chemistry, innovation, patent, pubchem, research
Organization: U.S. Department of Health & Human Services
Norepinephrine-evoked pain in fibromyalgia. A randomized pilot study [ISRCTN70707830]

Background
          Fibromyalgia syndrome displays sympathetically maintained pain features such as frequent post-traumatic onset and stimuli-independent pain accompanied by allodynia and paresthesias. Heart rate variability studies showed that fibromyalgia patients have changes consistent with ongoing sympathetic hyperactivity. Norepinephrine-evoked pain test is used to assess sympathetically maintained pain syndromes. Our objective was to define if fibromyalgia patients have norepinephrine-evoked pain.
        
        
          Methods
          Prospective double blind controlled study. Participants: Twenty FM patients, and two age/sex matched control groups; 20 rheumatoid arthritis patients and 20 healthy controls. Ten micrograms of norepinephrine diluted in 0.1 ml of saline solution were injected in a forearm. The contrasting substance, 0.1 ml of saline solution alone, was injected in the opposite forearm. Maximum local pain elicited during the 5 minutes post-injection was graded on a visual analog scale (VAS). Norepinephrine-evoked pain was diagnosed when norepinephrine injection induced greater pain than placebo injection. Intensity of norepinephrine-evoked pain was calculated as the difference between norepinephrine minus placebo-induced VAS scores.
        
        
          Results
          Norepinephrine-evoked pain was seen in 80 % of FM patients (95% confidence intervals 56.3 – 94.3%), in 30 % of rheumatoid arthritis patients and in 30 % of healthy controls (95% confidence intervals 11.9 – 54.3) (p < 0.05). Intensity of norepinephrine-evoked pain was greater in FM patients (mean ± SD 2.5 ± 2.5) when compared to rheumatoid arthritis patients (0.3 ± 0.7), and healthy controls (0.3 ± 0.8) p < 0.0001.
        
        
          Conclusions
          Fibromyalgia patients have norepinephrine-evoked pain. This finding supports the hypothesis that fibromyalgia may be a sympathetically maintained pain syndrome.

Tags: fibromyalgia, nih, norepinephrine, pain-study, sympathetic-pain
Organization: U.S. Department of Health & Human Services
Stratum corneum lipids liposomes for the topical delivery of 5-aminolevulinic acid in photodynamic therapy of skin cancer: preparation and in vitro permeation study

Background
          Photodynamic therapy (PDT) using 5-aminolevulinic acid (5-ALA) is a skin cancer therapy that still has limitations due to the low penetration of this drug into the skin. We have proposed in this work a delivery system for 5-ALA based on liposomes having lipid composition similar to the mammalian stratum corneum (SCLLs) in order to optimize its skin delivery in Photodynamic Therapy (PDT) of skin cancers.
        
        
          Methods
          SCLLs were obtained by reverse phase evaporation technique and size distribution of the vesicles was determinated by photon correlation spectroscopy. In vitro permeation profile was characterized using hairless mouse skin mounted in modified Franz diffusion cell.
        
        
          Results
          Size exclusion chromatography on gel filtration confirmed vesicle formation. SCLLs obtained by presented a degree of encapsulation of 5-ALA around 5.7%. A distribution of vesicle size centering at around 500 nm and 400 nm respectively for SCLLs and SCLLs containing 5-ALA was found. In vitro 5-ALA permeation study showed that SCLLs preparations presented higher skin retention significantly (p < 0.05) on the epidermis without SC + dermis, with a decreasing of skin permeation compared to aqueous solution.
        
        
          Conclusions
          The in vitro delivery performance provided by SCLLs lead to consider this systems adequate for the 5-ALA-PDT of skin cancer, since SCLLs have delivered 5-ALA to the target skin layers (viable epidermis + dermis) to be treated by topical PDT of skin cancer.

Tags: 5-aminolevulinic-acid, liposome-delivery, nih, photodynamic-therapy, skin-cancer
Organization: U.S. Department of Health & Human Services
Compound 528948: Phenol, 2-(1-ethylbutyl)-6-nitro

Chemical compound data from PubChem database. IUPAC Name: 2-hexan-3-yl-6-nitrophenol. Molecular Formula: C12H17NO3. Molecular Weight: 223.27. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Child Maltreatment 2017

This report presents national data about child abuse and neglect known to child protective services agencies in the United States during federal fiscal year 2017.

Letter from the Associate Commissioner

Acknowledgements

Summary

CHAPTER 1: Introduction

CHAPTER 2: Reports

CHAPTER 3: Children

CHAPTER 4: Fatalities

CHAPTER 5: Perpetrators

CHAPTER 6: Services

APPENDIX A: CAPTA Data Items

APPENDIX B: Glossary

APPENDIX C: State Characteristics

APPENDIX D: State Commentary

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: abuse, assessment, fiscal, maltreatment, neglect
Organization: U.S. Department of Health & Human Services
Ohio: 2011-2012 NSDUH

This report presents Ohio\'s estimates for 25 measures of substance use and mental health based on the combined 2011 and 2012 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided by State and for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: mental-health, ohio-nsduh, samhsa, serious-mental-illness, substance-use
Organization: U.S. Department of Health & Human Services
Plasma proteins in a standardised skin mini-erosion (II): effects of extraction pressure

Background
          A standardised suction technique has been used to sample plasma proteins in dermal interstitial fluid (IF) serially for 5 to 6 days from a suction-induced skin mini-erosion. Increased protein concentrations ascribed to inflammation have been shown from day 1 onward. In this study, we assessed the effect of two different extraction pressures on IF sample composition.
        
        
          Methods
          Total protein concentration and the concentrations of insulin, prealbumin, albumin, transferrin, IgG and alpha-2-macroglobulin were assessed daily in healthy volunteers. Samples were extracted at 50 mmHg and 200 mmHg below the atmospheric.
        
        
          Results
          At 0 h after forming the erosion, mean total IF protein content (relative to plasma) was lower in the samples extracted at -200 mmHg than at -50 mmHg (26 +/-13% (SD) vs 48 +/-9.8%; p < 0.05). There were no significant differences at 24, 48, 72 or 96 h. Of the individual proteins, expressed as area units (AU) for area under the curve (AUC) from 0–96 h, albumin was lower in IF sampled at -200 mmHg (2.49 +/- 0.68 vs 3.08 +/- 0.36 AU; p < 0.05), as was transferrin (1.91 +/- 0.52 vs 2.40 +/- 0.42 AU; p < 0.05). Extraction volumes were significantly higher at -200 mmHg (AUC diff: 60%; p < 0.05).
        
        
          Conclusions
          Samples of IF extracted at 0 h at -200 mmHg contained lower protein concentrations, indicating an increased water fraction and an intact sieve function of the vascular wall. The difference in protein concentration extracted at higher and lower pressure from 24 h onward was less pronounced. Lower pressure should be used to sample substances of greater molecular size.

Tags: dermal-interstitial-fluid, nih, plasma-proteins, skin-mini-erosion, suction-technique
Organization: U.S. Department of Health & Human Services
Compound 525291: 1-Chloro-2-methoxyprop-1-ene

Chemical compound data from PubChem database. IUPAC Name: 1-chloro-2-methoxyprop-1-ene. Molecular Formula: C4H7ClO. Molecular Weight: 106.55. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 530599: 4-Cyanobenzoic acid, dodec-9-ynyl ester

Chemical compound data from PubChem database. IUPAC Name: dodec-9-ynyl 4-cyanobenzoate. Molecular Formula: C20H25NO2. Molecular Weight: 311.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Adolescent standing postural response to backpack loads: a randomised controlled experimental study

Background
          Backpack loads produce changes in standing posture when compared with unloaded posture. Although 'poor' unloaded standing posture has been related to spinal pain, there is little evidence of whether, and how much, exposure to posterior load produces injurious effects on spinal tissue. The objective of this study was to describe the effect on adolescent sagittal plane standing posture of different loads and positions of a common design of school backpack. The underlying study aim was to test the appropriateness of two adult 'rules-of-thumb'-that for postural efficiency, backpacks should be worn high on the spine, and loads should be limited to 10% of body weight.
        
        
          Method
          A randomised controlled experimental study was conducted on 250 adolescents (12–18 years), randomly selected from five South Australian metropolitan high schools. Sagittal view anatomical points were marked on head, neck, shoulder, hip, thigh, knee and ankle. There were nine experimental conditions: combinations of backpack loads (3, 5 or 10% of body weight) and positions (backpack centred at T7, T12 or L3). Sagittal plane photographs were taken of unloaded standing posture (baseline), and standing posture under the experimental conditions. Posture was quantified from the x (horizontal) coordinate of each anatomical point under each experimental condition. Differences in postural response were described, and differences between conditions were determined using Analysis of Variance models.
        
        
          Results
          Neither age nor gender was a significant factor when comparing postural response to backpack loads or conditions. Backpacks positioned at T7 produced the largest forward (horizontal) displacement at all the anatomical points. The horizontal position of all anatomical points increased linearly with load.
        
        
          Conclusion
          There is evidence refuting the 'rule-of-thumb' to carry the backpack high on the back. Typical school backpacks should be positioned with the centre at waist or hip level. There is no evidence for the 10% body weight limit.

Tags: adolescent-posture, backpack-load, nih, randomized-controlled-trial, spinal-biomechanics
Organization: U.S. Department of Health & Human Services
N-SUMHSS 2021 Questionnaire

This is the questionnaire for the 2021 National Substance Use and Mental Health Services Survey (N-SUMHSS). The N-SUMHSS is a voluntary annual survey of all active substance use and mental health facilities in the United States, its jurisdictions, and the District of Columbia. This document shows the series of questions mental health and substance abuse treatment facilities were asked for the N-SUMHSS.The survey consists of two introductory questions and four separate modules. Skip patterns in the survey direct participants on relevant modules depending on whether the facility is a substance use treatment facility, a mental health treatment facility, or both.Additionally, facilities operated by the Department of Veteran’s Affairs (VA) were asked to complete additional questions regarding VA services offered.The web questionnaire and other addenda are available as PDF files.

Tags: behavioral-health, facility-survey, mental-health-services, samhsa, substance-use-treatment
Organization: U.S. Department of Health & Human Services
Compound 530651: p-Toluic acid, tridec-2-ynyl ester

Chemical compound data from PubChem database. IUPAC Name: tridec-2-ynyl 4-methylbenzoate. Molecular Formula: C21H30O2. Molecular Weight: 314.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 528155: Methyl 2-methyl-2-propylpentanoate

Chemical compound data from PubChem database. IUPAC Name: methyl 2-methyl-2-propylpentanoate. Molecular Formula: C10H20O2. Molecular Weight: 172.26. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Patent AT-E399747-T1: [Translated] METHOD FOR PRODUCING ALKYLAROMATIC COMPOUNDS

Production of alkylaromatic compounds (I), by reacting 3-30C olefins (II) (or alcohols forming (II) under the reaction conditions) with aromatic hydrocarbons (III) in presence of an alkylation catalyst (IV), is carried out in a cascade of at least two reactors each containing (IV), where at least 80 % of (III) is supplied to the first reactor of the cascade and at least 40 % of (II) is supplied after the first reactor. An independent claim is included for the preparation of alkylarylsulfonates (A), by: (1) converting a 4C olefin mixture over a metathesis catalyst to give an olefin mixture containing 2-pentene and/or 2-hexene; (2) catalytically dimerizing the 2-pentene and/or 2-hexene (optionally after isolation) to give a mixture containing 10-12C olefins, optionally separating the 10-12C olefins and separating 5-30 wt. % (based on the 10-12C olefins) of low-boiling components of the 10-12C olefins; (3) reacting the obtained 10-12C olefin mixture with (III) in presence of (IV) to give alkylaromatic compounds (I'), optionally with addition of 0-60 wt. % (based on the 10-12C olefin mixture) of linear olefins before the reaction; (4) sulfonating (I') and neutralizing to give (A), optionally with addition of 0-60 wt. % (based on (I')) of linear alkylbenzenes (provided that no mixing has been carried out in the previous step); and (5) optionally mixing the obtained (A) with optionally with addition of 0-60 wt. % (based on (A)) of linear aralkylsulfonates (provided that no mixing has been carried out either of the previous two steps); The novel feature being that the reaction in the alkylation stage (3) is carried out as for the present procedure for preparing (I).

Tags: chemistry, innovation, patent, pubchem, research
Organization: U.S. Department of Health & Human Services