AndreaBozzo/ceres-open-data-index huggingface dataset:
Response to Fionula Brennan's Commentary "A follow-up to 'Anti-cytokine therapy in chronic destructive arthritis' by Wim B van den Berg"

Response to Fionula Brennan's Commentary "A follow-up to 'Anti-cytokine therapy in chronic destructive arthritis' by Wim B van den Berg"

Tags: anti-cytokine-therapy, arthritis, chronic-arthritis, destructive-arthritis, nih
Organization: U.S. Department of Health & Human Services
Compound 525635: N,N-Dimethyl-N'-nonyl-p-chlorobenzamidine

Chemical compound data from PubChem database. IUPAC Name: 4-chloro-N,N-dimethyl-N'-nonylbenzenecarboximidamide. Molecular Formula: C18H29ClN2. Molecular Weight: 308.9. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Adoption Data 2009

This webpage includes reports on state-specific adoption statistics for fiscal year 2009.

Receiving Adoption Subsidy: 10/1/2008 - 9/30/2009
Adoptive Family Structure: 10/1/2008 - 9/30/2009
Age at Adoption Finalization: 10/1/2008 - 9/30/2009
Prior Relationship of Adoptive Parent(s) to Child: 10/1/2008 - 9/30/2009
Race/Ethnicity of Public Agency Children Adopted: 10/1/2008 - 9/30/2009
Sex of Public Agency Children Adopted: 10/1/2008 - 9/30/2009
Child is Identified as a Special Needs Adoption: 10/1/2008 - 9/30/2009
Time between Termination of Parental Rights (TPR) and Adoption Finalization: 10/1/2008 - 9/30/2009

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: adoption, child, data, fiscal, policy
Organization: U.S. Department of Health & Human Services
Research Article: BMC Genomics

Background
          Gonadotropin releasing hormone (GnRH) is responsible for stimulation of gonadotropic hormone (GtH) in the hypothalamus-pituitary-gonadal axis (HPG). The regulatory mechanisms responsible for brain specificity make the promoter attractive for in silico analysis and reporter gene studies in zebrafish (Danio rerio).
        
        
          Results
          We have characterized a zebrafish [Trp7, Leu8] or salmon (s) GnRH variant, gnrh3. The gene includes a 1.6 Kb upstream regulatory region and displays the conserved structure of 4 exons and 3 introns, as seen in other species. An in silico defined enhancer at -976 in the zebrafish promoter, containing adjacent binding sites for Oct-1, CREB and Sp1, was predicted in 2 mammalian and 5 teleost GnRH promoters. Reporter gene studies confirmed the importance of this enhancer for cell specific expression in zebrafish. Interestingly the promoter of human GnRH-I, known as mammalian GnRH (mGnRH), was shown capable of driving cell specific reporter gene expression in transgenic zebrafish.
        
        
          Conclusions
          The characterized zebrafish Gnrh3 decapeptide exhibits complete homology to the Atlantic salmon (Salmo salar) GnRH-III variant. In silico analysis of mammalian and teleost GnRH promoters revealed a conserved enhancer possessing binding sites for Oct-1, CREB and Sp1. Transgenic and transient reporter gene expression in zebrafish larvae, confirmed the importance of the in silico defined zebrafish enhancer at -976. The capability of the human GnRH-I promoter of directing cell specific reporter gene expression in zebrafish supports orthology between GnRH-I and GnRH-III.

Tags: gene-expression, gnrh-gene, hypothalamus-pituitary-gonadal, nih, zebrafish-genome
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Connecticut, 2015

This is a behavioral health report for the state of Connecticut. The report utilizes data from the National Survey on Drug Use and Health (NSDUH), and the Uniform Reporting System. The topics addressed in the report include youth substance use, youth mental health and treatment, mental health and treatment, substance use and substance use treatment.

Tags: connecticut-behavioral-health, mental-health-treatment, nsduh-data, samhsa, youth-substance-use
Organization: U.S. Department of Health & Human Services
2018 Uniform Reporting System (URS) Table for Iowa

This is the 2018 Uniform Reporting System (URS) Output Tables for Iowa. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-program, mental-health-services, national-outcome-measures, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
Compound 525418: 1-(2-Methylpropylsulfanyl)butane

Chemical compound data from PubChem database. IUPAC Name: 1-(2-methylpropylsulfanyl)butane. Molecular Formula: C8H18S. Molecular Weight: 146.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 525216: Methyl undecyl phthalate

Chemical compound data from PubChem database. IUPAC Name: 1-O-methyl 2-O-undecyl benzene-1,2-dicarboxylate. Molecular Formula: C20H30O4. Molecular Weight: 334.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
FY 2017 Children's Bureau Discretionary Grant Awards

This document provides a list of Children's Bureau discretionary grants awarded in fiscal year 2017:

First year award amount is up to $1,000,000, project period is up to five years

First year award amount is up to $5,170,000, project period is up to 5 years

First year award amount is up to $3,000,000, project period is up to 3 years

Award amount is up to $750,000 for a single 18-month project and budget period

First year award amount is up to $1,000,000, project period is up to 5 years

First year award amount is up to $600,000, project period is up to 5 years

First year award amount is up to $600,000, project period is up to 5 years

Up to $300,000 for a single two year project and budget period

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: award, child, fiscal, grant, policy
Organization: U.S. Department of Health & Human Services
Maine (ME)

This report presents Maine\'s estimates for 25 measures of substance use and mental health based on the combined 2009 and 2010 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for Maine for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: maine, mental-health, nsduh, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Why do antioxidants fail to provide clinical benefit?

The results of recent randomized trials to test the influence of antioxidants on coronary-event rates and prognosis in patients with coronary-artery disease were disappointing. In none of these studies did the use of vitamin E improve prognosis. In contrast, treatment of coronary-artery disease with angiotensin-converting-enzyme (ACE) inhibitors reduced coronary-event rates and improved prognosis. ACE inhibition prevents the formation of angiotensin II, which has been shown to be a potent stimulus of superoxide-producing enzymes in atherosclerosis. The findings suggest that inhibition of superoxide production at enzymatic levels, rather than symptomatic superoxide scavenging, may be the better choice of treatment.

Tags: ace-inhibitors, antioxidant-therapy, coronary-artery-disease, nih, superoxide-production
Organization: U.S. Department of Health & Human Services
Reliability of race assessment based on the race of the ascendants: a cross-sectional study

Background
          Race is commonly described in epidemiological surveys based on phenotypic characteristics. Training of interviewers to identify race is time-consuming and self identification of race might be difficult to interpret. The aim of this study was to determine the agreement between race definition based on the number of ascendants with black skin colour, with the self-assessment and observer's assessment of the skin colour.
        
        
          Methods
          In a cross-sectional study of 50 women aged 14 years or older, from an outpatient clinic of an University affiliated hospital, race was assessed through observation and the self-assignment of the colour of skin and by the number of black ascendants including parents and grandparents. Reliability was measured through Kappa coefficient.
        
        
          Results
          Agreement beyond chance between self-assigned and observed skin colour was excellent for white (0.75 95% CI 0.72–0.78) and black women (0.89 95% CI 0.71–0.79), but only good for participants with mixed colour (0.61 95% CI 0.58–0.64), resulting in a global kappa of 0.75 (95% CI 0.71–0.79). However, only a good agreement for mixed women was obtained. The presence of 3 or more black ascendants was highly associated with observed and self-assessed black skin colour. Most women self-assigned or observed as white had no black ascendants.
        
        
          Conclusions
          The assessment of race based on the race of ascendants showed reasonable agreement with the ascertainment done by trained interviewers and with the self-report of race. This method may be considered for evaluation of race in epidemiological surveys, since it is less time-consuming than the evaluation by interviewers.

Tags: kappa-coefficient, nih, race-assessment, racial-disparities, skin-color
Organization: U.S. Department of Health & Human Services
Compound 525659: p-Bromobenzylidene-(4-bromophenyl)-amine

Chemical compound data from PubChem database. IUPAC Name: N,1-bis(4-bromophenyl)methanimine. Molecular Formula: C13H9Br2N. Molecular Weight: 339.02. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 528384: Benzaldehyde, 3,4,5-trichloro-2-hydroxy

Chemical compound data from PubChem database. IUPAC Name: 3,4,5-trichloro-2-hydroxybenzaldehyde. Molecular Formula: C7H3Cl3O2. Molecular Weight: 225.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2010 State Profile — Iowa

This state profile includes data from facilities in Iowa that reported to N-SSATS for the survey reference date March 31, 2010. Data were collected on the location, characteristics, services offered, and number of clients in treatment at alcohol and drug abuse treatment facilities (both public and private) in Iowa. In Iowa, 125 substance abuse treatment facilities were included in the 2010 N-SSATS, reporting that there were 7,747 clients in substance abuse treatment on March 31, 2010. The survey response rate in Iowa was 98.6%.

Tags: alcohol-drug-abuse, iowa, n-ssats, samhsa, substance-abuse-treatment
Organization: U.S. Department of Health & Human Services
Clonal expansion is a characteristic feature of the B-cell repertoire
		  of patients with rheumatoid arthritis

The present study was designed to analyze the level of B-cell clonal
			 diversity in patients with rheumatoid arthritis by using HCDR3 (third
			 complementarity determining region of the rearranged heavy chain variable
			 region gene) length as a marker. A modified immunoglobulin VH gene
			 fingerprinting method using either genomic DNA or complementary (c)DNA derived
			 from B cells of the peripheral blood, synovial fluid, and tissues of several
			 rheumatoid arthritis patients was employed. These assays permitted the
			 detection and distinction of numerically expanded B-cell clones from activated
			 but not numerically expanded B-cell clones. The present data suggest that
			 B-cell clonal expansion is a common and characteristic feature of rheumatoid
			 arthritis and that it occurs with increasing frequency from the blood to the
			 synovial compartments, resulting in a narrowing of the clonal repertoire at the
			 synovial level. These clonal expansions can involve resting, apparently memory
			 B cells, as well as activated B cells. Furthermore, some of these individual
			 expansions can persist over extended periods of time. These findings support
			 the hypothesis that a chronic ongoing (auto)immune reaction is operative in
			 rheumatoid arthritis and that this reaction, at least at the B-cell level, may
			 be unique to each individual joint. A determination of the targets of these
			 autoimmune reactions may provide valuable clues to help understand the
			 immunopathogenesis of this disease.

Tags: b-cell-clones, immunoglobulin-vh, nih, rheumatoid-arthritis, synovial-fluid
Organization: U.S. Department of Health & Human Services
DSM-5 Changes:  Implication for Child Serious Emotional Disturbance

This report describes the differences between the DSM-IV and DSM-5 diagnostic criteria that could affect national estimates of childhood serious emotional disturbance (SED). The report also provides a description of DSM-5 updates that have been made to existing diagnostic instruments and screeners of childhood emotional and behavioral health.

Tags: child-sed, diagnostic-criteria, dsm-5, emotional-disturbance, samhsa
Organization: U.S. Department of Health & Human Services
Maine (ME)

This report presents estimates for measures of substance use and mental health based on the combined 2010 and 2011 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for Maine for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: maine, mental-health, nsduh, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Non-enzymatic glycosylation of a type I collagen matrix: effects on osteoblastic development and oxidative stress

Background
          The tissue accumulation of protein-bound advanced glycation endproducts (AGE) may be involved in the etiology of diabetic chronic complications, including osteopenia. The aim of this study was to investigate the effect of an AGE-modified type I collagen substratum on the adhesion, spreading, proliferation and differentiation of rat osteosarcoma UMR106 and mouse non-transformed MC3T3E1 osteoblastic cells. We also studied the role of reactive oxygen species (ROS) and nitric oxide synthase (NOS) expression on these AGE-collagen mediated effects.
        
        
          Results
          AGE-collagen decreased the adhesion of UMR106 cells, but had no effect on the attachment of MC3T3E1 cells. In the UMR106 cell line, AGE-collagen also inhibited cellular proliferation, spreading and alkaline phosphatase (ALP) activity. In preosteoblastic MC3T3E1 cells (24-hour culture), proliferation and spreading were significantly increased by AGE-collagen. After one week of culture (differentiated MC3T3E1 osteoblasts) AGE-collagen inhibited ALP activity, but had no effect on cell number. In mineralizing MC3T3E1 cells (3-week culture) AGE-collagen induced a decrease in the number of surviving cells and of extracellular nodules of mineralization, without modifying their ALP activity. Intracellular ROS production, measured after a 48-hour culture, was decreased by AGE-collagen in MC3T3E1 cells, but was increased by AGE-collagen in UMR106 cells. After a 24-hour culture, AGE-collagen increased the expression of endothelial and inducible NOS, in both osteoblastic cell lines.
        
        
          Conclusions
          These results suggest that the accumulation of AGE on bone extracellular matrix could regulate the proliferation and differentiation of osteoblastic cells. These effects appear to depend on the stage of osteoblastic development, and possibly involve the modulation of NOS expression and intracellular ROS pathways.

Tags: advanced-glycation-endproducts, collagen-glycosylation, nih, osteoblast-development, oxidative-stress
Organization: U.S. Department of Health & Human Services
Compound 525558: Benzylideneoctylamine

Chemical compound data from PubChem database. IUPAC Name: N-octyl-1-phenylmethanimine. Molecular Formula: C15H23N. Molecular Weight: 217.35. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 525397: 2,7-Dithianonane

Chemical compound data from PubChem database. IUPAC Name: 1-ethylsulfanyl-4-methylsulfanylbutane. Molecular Formula: C7H16S2. Molecular Weight: 164.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Desferrioxamine decreases NAD redox potential of intact red blood cells: evidence for desferrioxamine as an inducer of oxidant stress in red blood cells

Background
          Desferrioxamine (DFO) is an important iron chelating agent. It has also been thought of as an agent with anti-oxidant potential as it chelates ferric iron in various parts of the body. However, there is evidence suggesting that it may paradoxically affect red blood cells (RBC) by inducing intracellular oxidant stress. To further understand the mechanism of DFO's interaction with RBC, we conducted a study to determine the effect of DFO upon RBC's redox status.
        
        
          Methods
          We examined NAD redox potential in intact RBC (N = 5) incubated with DFO. RBC were incubated with 6 mM DFO for 2 hours.
        
        
          Results
          Significant decreases in NAD redox potential were observed after incubation of RBC with 6 mM DFO. The mean decrease was 10.01 ± 1.98% (p < 0.0004).
        
        
          Conclusions
          The data confirm the oxidant effect of DFO on RBC.

Tags: desferrioxamine-toxicity, nad-redox-potential, nih, oxidative-stress, red-blood-cells
Organization: U.S. Department of Health & Human Services
Compound 525472: 4,6-Dithiadecane

Chemical compound data from PubChem database. IUPAC Name: 1-(propylsulfanylmethylsulfanyl)pentane. Molecular Formula: C9H20S2. Molecular Weight: 192.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: HHS Region VIII, 2014

This is a behavioral health report for HHS Region VIII of the United States and utilizes data from the National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment (N-SSATS), collected annually. The topics addressed in the reports include youth mental health, adult mental health, and substance use.

Tags: behavioral-health, hhs-region-viii, mental-health, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Education Exchange: State Panel Discussion

This state panel discussion, featuring Alabama, District of Columbia, and Wisconsin, discussed sharing child welfare and education data to improve practice and outcomes. Panelists shared the history of their exchanges along with future visions for their exchanges. In addition, panelists discussed the lessons learned from building relationships between child welfare agencies and education agencies and developing data exchanges between them. The panel included several question and answer sessions throughout the presentation.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: child, policy, reporting, sery, time
Organization: U.S. Department of Health & Human Services
Angiogenesis in the pathogenesis of inflammatory joint and lung diseases

This paper reviews hypotheses about roles of angiogenesis in the pathogenesis of inflammatory disease in two organs, the synovial joint and the lung. Neovascularisation is a fundamental process for growth and tissue repair after injury. Nevertheless, it may contribute to a variety of chronic inflammatory diseases, including rheumatoid arthritis, osteoarthritis, asthma, and pulmonary fibrosis. Inflammation can promote angiogenesis, and new vessels may enhance tissue inflammation. Angiogenesis in inflammatory disease may also contribute to tissue growth, disordered tissue perfusion, abnormal ossification, and enhanced responses to normal or pathological stimuli. Angiogenesis inhibitors may reduce inflammation and may also help to restore appropriate tissue structure and function.

Tags: angiogenesis, angiogenesis-inhibitors, inflammatory-arthritis, lung-inflammation, nih
Organization: U.S. Department of Health & Human Services
2021 Uniform Reporting System (URS) Table For Utah

This is the 2021 Uniform Reporting System (URS) Output Tables for Utah. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-program, mental-health-services, national-outcome-measures, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services