AndreaBozzo/ceres-open-data-index huggingface dataset:
Child Abuse Prevention and Treatment Act (CAPTA) State Grants

Program Description

The Child Abuse Prevention and Treatment Act (CAPTA) State Grant program provides grants to help states improve child protective service systems. This program assists states in improving: intake, assessment, screening and investigation of child abuse and neglect reports; risk and safety assessment protocols; training for child protective services workers and mandated reporters; programs and procedures for the identification, prevention and treatment of child abuse and neglect; development and implementation of procedures for collaboration among child protection services, domestic violence, and other agencies; and services to disabled infants with life-threatening conditions and their families. In addition, under this program, states perform a range of prevention activities, including addressing the needs of infants born with prenatal drug exposure, referring children not at risk of imminent harm to community services, implementing criminal record checks for prospective foster and adoptive parents and other adults in their homes, training child protective services workers, protecting the legal rights of families and alleged perpetrators, and supporting Citizen Review Panels.

Since FY 2018, Congress has directed that $60 million of the annual appropriation be used to help states improve their response to the families of infants affected by substance use disorders. States are required to use a substantial portion of their annual grant to strengthen procedures for the development, implementation and monitoring of plans of safe care for substance-exposed infants and their caretakers.

Budget Information

FY 2024: $105 million

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: abuse, grant, neglect, policy, prevention
Organization: U.S. Department of Health & Human Services
Compound 525584: N,N-Dimethyl-N'-(3-nitrophenyl)-p-methoxybenzamidine

Chemical compound data from PubChem database. IUPAC Name: 4-methoxy-N,N-dimethyl-N'-(3-nitrophenyl)benzenecarboximidamide. Molecular Formula: C16H17N3O3. Molecular Weight: 299.32. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Building Strong Families (BSF)

The Building Strong Families (BSF) project examined the effectiveness of programs designed to improve child well-being and strengthen the relationships of low-income couples through relationship skills education. It surveyed couples 15 months and 36 months after having applied to and been accepted into a Building Stronger Families (BSF) program at one of eight locations offering services to unwed couples expecting, or having recently had a baby. Major topics included family structure, parental involvement with children, relationships, personal and parental well-being, utilization of services such as workshops to help their relationship and parenting skills, paternity and child support, and family self-sufficiency. Respondents were asked for information on recently born children and relationship status, how much time they spent with their children, their level of satisfaction with their current relationship, substance use, if they had attended relationship and parental counseling, whether they were legally required to provide child support, employment, and family background. Additional information was asked about domestic violence and child abuse, legal trouble, past sexual history, and child development. The 36-month data collection effort also included direct assessments of parenting and child development. The quality of the parenting relationship was assessed for both mothers and fathers and was based on a semi-structured play activity, "the two-bag task." This interaction was videotaped and later coded by trained assessors on multiple dimensions of parenting. During assessments with mothers, the focal child's language development was also assessed using the Peabody Picture Vocabulary Test. Demographic data includes race, education level, age, income, and marital status. The data collection is comprised of seven parts. Part 1: the BSF Eligibility and Baseline Survey Data file; Part 2: the BSF 15-Month Follow-up Survey Data file; Part 3: the program participation data file; Part 4: the BSF 15-month follow-up analysis file; Part 5: the BSF 36-Month Follow-up Survey Data file; Part 6: the mother-child in-home assessment; and Part 7: the BSF 36-Month Follow-up analysis file.

<b>Units of Response: </b>Low-income couples with children

<b>Type of Data: </b>Evaluation

<b>Tribal Data: </b>No

<b>COVID-19 Data: </b>No

<b>Periodicity: </b>One-time

<b>SORN: </b>https://www.federalregister.gov/documents/2022/09/19/2022-20139/privacy-act-of-1974-system-of-records

<b>Data Use Agreement: </b>https://www.icpsr.umich.edu/rpxlogin

<b>Data Use Agreement Location: </b>https://www.icpsr.umich.edu/web/ICPSR/studies/29781/datadocumentation

<b>Equity Indicators: </b>Sex 

<b>Granularity: </b>Household;Individual

<b>Spatial: </b>United States

<b>Geocoding: </b>Unavailable

Tags: children-and-families, family-assistance, research-and-evaluation
Organization: U.S. Department of Health & Human Services
Breast cancer mortality among Ashkenazi Jewish women in São Paulo and Porto Alegre, Brazil

Background
          Increased BRCA1 and BRCA2 germline mutation rates have been reported in Ashkenazi Jewish women in North America, Europe and Israel, and have been mentioned as possibly related to a higher incidence of breast and ovarian cancer among these communities. The present study was carried out with the aim of obtaining evidence on the magnitude of breast cancer as a cause of death among Ashkenazi women in Brazil.
        
        
          Methods
          We reviewed all death certificates archived in the Jewish Burial Societies of São Paulo (1971-1997) and Porto Alegre (1948-1997), two of the main and oldest Jewish communities in Brazil. Breast cancer observed deaths were compared with expected deaths according to breast cancer mortality in the general population.
        
        
          Results
          The observed ratios were approximately quite close to unity, suggesting a similar breast cancer mortality pattern among the Ashkenazi population and the general population in both cities. These results maintain similar behavior regardless of whether analyzed before or after the mid-1980s, when mammography came to be increasingly performed in Brazil. Cancer proportional mortality ratios were 1.04 (0.83-1.29) in São Paulo and 1.16 (0.84-1.57) in Porto Alegre before 1985, and 1.17 (1.00-1.44) and 1.21 (0.81-1.79), respectively, between 1985 and 1997. Some evidence of the maintenance of protective risk factors such as high parity has been observed among Ashkenazi women in São Paulo.
        
        
          Conclusion
          A quite similar breast cancer mortality pattern was observed between Ashkenazi Jewish women and the general population in São Paulo and Porto Alegre, Brazil. These results may suggest an environmental role on germ mutation expression reported in this ethnic group.

Tags: ashkenazi-jewish-women, brazil-mortality-study, brca1-brca2-mutation, breast-cancer-mortality, nih
Organization: U.S. Department of Health & Human Services
Apical accumulation of MARCKS in neural plate cells during neurulation in the chick embryo

Background
          The neural tube is formed by morphogenetic movements largely dependent on cytoskeletal dynamics. Actin and many of its associated proteins have been proposed as important mediators of neurulation. For instance, mice deficient in MARCKS, an actin cross-linking membrane-associated protein that is regulated by PKC and other kinases, present severe developmental defects, including failure of cranial neural tube closure.
        
        
          Results
          To determine the distribution of MARCKS, and its possible relationships with actin during neurulation, chick embryos were transversely sectioned and double labeled with an anti-MARCKS polyclonal antibody and phalloidin. In the neural plate, MARCKS was found ubiquitously distributed at the periphery of the cells, being conspicuously accumulated in the apical cell region, in close proximity to the apical actin meshwork. This asymmetric distribution was particularly noticeable during the bending process. After the closure of the neural tube, the apically accumulated MARCKS disappeared, and this cell region became analogous to the other peripheral cell zones in its MARCKS content. Actin did not display analogous variations, remaining highly concentrated at the cell subapical territory. The transient apical accumulation of MARCKS was found throughout the neural tube axis. The analysis of another epithelial bending movement, during the formation of the lens vesicle, revealed an identical phenomenon.
        
        
          Conclusions
          MARCKS is transiently accumulated at the apical region of neural plate and lens placode cells during processes of bending. This asymmetric subcellular distribution of MARCKS starts before the onset of neural plate bending. These results suggest possible upstream regulatory actions of MARCKS on some functions of the actin subapical meshwork.

Tags: chick-embryo, marcks-protein, neural-tube-closure, neurulation, nih
Organization: U.S. Department of Health & Human Services
Developmental expression of survivin during embryonic submandibular salivary gland development

Background
          The regulation of programmed cell death is critical to developmental homeostasis and normal morphogenesis of embryonic tissues. Survivin, a member of the inhibitors of apoptosis protein (IAP) family primarily expressed in embryonic cells, is both an anti-apoptosis and a pro-survival factor. Since our previous studies have demonstrated the importance of apoptosis during embryonic submandibular salivary gland (SMG) development, we postulated that survivin is a likely mediator of SMG epithelial cell survival.
        
        
          Results
          We investigated the developmental expression of survivin in Pseudoglandular (~ E14), Canalicular (~ E15) and Terminal Bud (~ E17) Stage SMGs. We report a significant 26% increase in transcript levels between the Canalicular and Terminal Bud Stages. Immunohistochemical studies demonstrate nuclear-localized survivin protein in epithelial cells bounding forming lumina in Canalicular and Terminal Bud Stage SMGs.
        
        
          Conclusions
          Survivin is known to be a pro-survival and anti-apoptotic factor. Given that survivin translocation into the nucleus is required for the induction of entry into the cell cycle and the inhibition of apoptosis, our demonstration of nuclear-localized survivin protein in presumptive ductal and proacinar lumen-bounding cells suggests that survivin may be a key mediator of embryonic SMG epithelial cell survival.

Tags: apoptosis-regulation, embryonic-development, nih, salivary-gland-development, survivin-expression
Organization: U.S. Department of Health & Human Services
2012 Uniform Reporting System (URS) Tables for North Dakota

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2012. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant, mental-health-services, north-dakota, outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Miami - Fort Lauderdale Div

Data tables consisting of Excel files with estimates, rates, relative standard errors, trends and confidence intervals, covering 2008-2011, for drug-related emergency department visits for the Fort Lauderdale Division of the Miami Metropolitan Statistical Area. Tables are provided for 10 topics (\"analytic categories\") which are defined in the \"Guide to Drug Abuse Warning Trend Tables,\"  a separate document.   Each table includes data for over 500 drugs, including illicit drugs, prescription and over-the-counter medications, dietary supplements, inhalants and alcohol. Includes total visits, gender, age group, race/ethnicity, outcome of visit, drug combinations, number of drugs involved in visit, drug frequency, and drugs confirmed by toxicology. Additional detail is provided for illicit drugs, psychotherapeutic drugs, central nervous system (CNS) drugs, respiratory drugs and cardiovascular drugs.

Tags: drug-related-ed-visits, emergency-department-data, samhsa, substance-abuse-trends, toxicology-confirmed-drugs
Organization: U.S. Department of Health & Human Services
2016  Uniform Reporting System (URS) Table for Florida

This is the 2016 Uniform Reporting System (URS) Output Tables for Florida. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: florida-mental-health, mental-health-services, national-outcome-measures, samhsa, substance-abuse-treatment
Organization: U.S. Department of Health & Human Services
Minneapolis: Drug-Related Emergency Department Visits, 2004-2011 - Nonmedical Use of Pharmaceuticals

Excel file with estimates, rates, relative standard errors, trends and confidence intervals for all drug-related emergency department (ED) visits involving the nonmedical use of pharmaceuticals (prescription and over-the-counter medications and dietary supplements) for the Minneapolis metropolitan area, covering 2004-2011.  Nonmedical use includes patients who took a higher than prescribed or recommended dose of their own medication, patients who took a pharmaceutical prescribed for another person, malicious poisoning of the patient by another individual, and documented substance abuse involving pharmaceuticals

Tags: drug-overdose, emergency-department, minneapolis, pharmaceutical-misuse, samhsa
Organization: U.S. Department of Health & Human Services
2011 CMHS Uniform Reporting System (URS) Output Tables for Connecticut

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2011. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-program, community-mental-health, mental-health-services, outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Notice of Allotment Percentages to States for Child Welfare Services State Grants - (Volume 76, Number 35)

Notice of Allotment Percentages to States for Child Welfare Services State Grants
  
  

 (PDF) - This notice from the Federal Register announces the allotment percentage for fiscal years 2012 and 2013 for each state under the title IV–B Subpart 1, which is the Child Welfare Services State Grants program.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: child, fiscal, grant, policy, scope
Organization: U.S. Department of Health & Human Services
2011 CMHS Uniform Reporting System (URS) Output Tables for Rhode Island

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2011. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, noms-measures, rhode-island, samhsa
Organization: U.S. Department of Health & Human Services
Compound 525676: p-Chlorobenzylidene-(3-bromophenyl)-amine

Chemical compound data from PubChem database. IUPAC Name: N-(3-bromophenyl)-1-(4-chlorophenyl)methanimine. Molecular Formula: C13H9BrClN. Molecular Weight: 294.57. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Treatment Episode Data Set (TEDS) 1998-2008 State Admissions to Substance Abuse Treatment Services

This report presents data from the Treatment Episode Data Set (TEDS) by census division and state and jurisdiction for admissions in 2008, and trend data for 1998 to 2008. The report provides information on the demographic and substance abuse characteristics of people aged 12 and older admitted to treatment for abuse of alcohol and/or drugs in facilities that report to individual state administrative data systems.

Tags: alcohol-drug-abuse, samhsa, substance-abuse-treatment, teds-admissions, treatment-episodes
Organization: U.S. Department of Health & Human Services
Cloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolases

Background
          The human genome contains at least 18 genes for Nudix hydrolase enzymes. Many have similar functions to one another. In order to understand their roles in cell physiology, these proteins must be characterised.
        
        
          Results
          We have characterised two novel human gene products, hAps1, encoded by the NUDT11 gene, and hAps2, encoded by the NUDT10 gene. These cytoplasmic proteins are members of the DIPP subfamily of Nudix hydrolases, and differ from each other by a single amino acid. Both metabolise diadenosine-polyphosphates and, weakly, diphosphoinositol polyphosphates. An apparent polymorphism of hAps1 has also been identified, which leads to the point mutation S39N. This has also been characterised. The favoured nucleotides were diadenosine 5',5"'-pentaphosphate (kcat/Km = 11, 8 and 16 × 103M-1s-1 respectively for hAps1, hAps1-39N and hAps2) and diadenosine 5',5"'-hexaphosphate (kcat/Km = 13, 14 and 11 × 103M-1s-1 respectively for hAps1, hAps1-39N and hAps2). Both hAps1 and hAps2 had pH optima of 8.5 and an absolute requirement for divalent cations, with manganese (II) being favoured. Magnesium was not able to activate the enzymes. Therefore, these enzymes could be acutely regulated by manganese fluxes within the cell.
        
        
          Conclusions
          Recent gene duplication has generated the two Nudix genes, NUDT11 and NUDT10. We have characterised their gene products as the closely related Nudix hydrolases, hAps1 and hAps2. These two gene products complement the activity of previously described members of the DIPP family, and reinforce the concept that Ap5A and Ap6A act as intracellular messengers.

Tags: diadenosine-polyphosphates, enzyme-characterization, haps1-haps2, nih, nudix-hydrolases
Organization: U.S. Department of Health & Human Services
Table 26. Had Serious Thoughts of Suicide in the Past Year among Persons Aged 18 or Older, by State and Substate Regions: Percentages, Annual Averages Based on 2008, 2009, and 2010 NSDUHs

This table presents the 2008 to 2010 National Survey on Drug Use and Health (NSDUH) estimates of past year serious thoughts of suicide among those aged 18 or older by State and substate regions.

Tags: adult-mental-health, nsduh-survey, samhsa, state-level-data, suicidal-ideation
Organization: U.S. Department of Health & Human Services
2021 Uniform Reporting System (URS) Table For District Of Columbia

This is the 2021 Uniform Reporting System (URS) Output Tables for District of Columbia. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-program, community-mental-health, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Hormone replacement therapy and prevention of vertebral fractures: a meta-analysis of randomised trials

Background
          Hormone replacement therapy (HRT) is often seen as the treatment of choice for preventing fractures in women. We undertook a recent meta-analysis of randomised trials which suggested that HRT reduced non-vertebral fractures by 30%. In this analysis we extend that analysis to vertebral fractures.
        
        
          Methods
          We searched the main electronic databases until the end of August 2001. We sought all randomised controlled trials (RCTs) of HRT where women had been randomised to at least 12 months of HRT or to no HRT.
        
        
          Results
          We found 13 RCTs. Overall there was a 33% reduction in vertebral factures (95% confidence interval (CI) 45% to 98%).
        
        
          Conclusions
          This review and meta-analysis showed a significant reduction in vertebral fractures associated with HRT use.

Tags: hormone-replacement-therapy, meta-analysis, nih, osteoporosis, vertebral-fractures
Organization: U.S. Department of Health & Human Services
Compound 528572: tert-Butyl(dimethyl)silyl decanoate

Chemical compound data from PubChem database. IUPAC Name: [tert-butyl(dimethyl)silyl] decanoate. Molecular Formula: C16H34O2Si. Molecular Weight: 286.52. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Miscellaneous Tables (Standard Errors and P Values) - 6.1 to 6.107

These detailed tables present the standard errors for the totals and prevalence estimates of the number of days and types of substance use, poly-drug use, nicotine dependence, substance dependence by age of first use, source of substances, social context of substance use, and drunk/drugged driving from the 2012 National Survey on Drug Use and Health (NSDUH). Substances examined include illicit drugs, marijuana, cocaine, heroin, hallucinogens, inhalants, and the nonmedical use of prescription-type pain relievers, tranquilizers, stimulants, and sedatives, and alcohol. Standard errors are provided for totals and prevalence estimates of lifetime, past year, and past month use by age group, gender, race/ethnicity, education level, employment status, geographic area, pregnancy status, college enrollment status, and probation/parole status. Comparisons are made between 2012 and 2011.

Tags: nsduh-2012, prevalence-estimates, samhsa, standard-errors, substance-use
Organization: U.S. Department of Health & Human Services