AndreaBozzo/ceres-open-data-index huggingface dataset:
Death, autoantigen modifications, and tolerance

Autoantibodies present in the serum of patients with a variety of inflammatory diseases have proven useful as diagnostic markers and as probes with which to elucidate biochemical and signaling pathways. The mechanisms governing the generation of autoantibodies remain elusive, constituting a critical missing link in our understanding of rheumatologic illnesses. Several lines of experimentation in recent years have strongly implicated events surrounding cell death in this process. This review will address the potential role played by death-specific modifications of autoantigens in bypassing tolerance to highly conserved autoantigens, including nucleic acids, lipids, and proteins.

Tags: autoantibody-production, autoimmune-diseases, cell-death-modifications, immunological-tolerance, nih
Organization: U.S. Department of Health & Human Services
Compound 528350: 2,4-Adamantanedione

Chemical compound data from PubChem database. IUPAC Name: adamantane-2,4-dione. Molecular Formula: C10H12O2. Molecular Weight: 164.2. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 525390: Isopropyl isobutyl disulfide

Chemical compound data from PubChem database. IUPAC Name: 2-methyl-1-(propan-2-yldisulfanyl)propane. Molecular Formula: C7H16S2. Molecular Weight: 164.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Miami - Dade Div: Drug-Related Emergency Department Visits, 2004-2011 - Adverse Reactions

Excel file with estimates, rates, relative standard errors, trends and confidence intervals, covering 2004-2011 for emergency department visits involving adverse reactions in the Miami metropolitan area, Dade County division. It includes ED visits in which an adverse health consequence (e.g., side effects or an allergic reaction) resulted when taking prescription drugs, over-the-counter medications, or dietary supplements as prescribed or recommended.  This analytic category does not include drug misuse or abuse.File includes data for over 500 drugs, including illicit drugs, prescription and over-the-counter medications, dietary supplements, inhalants and alcohol.  Includes total visits, gender, age group, race/ethnicity, outcome of visit, drug combinations, number of drugs involved in visit, drug frequency, and drugs confirmed by toxicology.Additional detail is provided for illicit drugs, psychotherapeutic drugs, central nervous system (CNS) drugs, respiratory drugs and cardiovascular drugs.

Tags: adverse-drug-reactions, drug-related-events, emergency-department-visits, miami-dade-county, samhsa
Organization: U.S. Department of Health & Human Services
Hedgehog signal transduction proteins: contacts of the Fused kinase and Ci transcription factor with the Kinesin-related protein Costal2

Background
          Hedgehog signaling proteins play important roles in development by controlling growth and patterning in various animals including Drosophila and mammals. Hedgehog signaling triggers changes in responsive cells through a novel transduction mechanism that ultimately controls the transcription of specific target genes via the activity of zinc finger transcription factors of the Cubitus interruptus /GLI family. In flies, key Hedgehog signal transduction components have been identified including the kinesin-related protein Costal2, the serinethreonine kinase Fused, and the PEST-containing protein Suppressor of Fused. These proteins control Cubitus interruptus cleavage, nucleo-cytoplasmic localization and activation. In fly embryos, Costal2, Fused, Suppressor of Fused and Cubitus interruptus are associated in at least one cytoplasmic complex, which interacts with the microtubules in a Hedgehog-dependent manner.
        
        
          Results
          Here we identified and mapped direct interactions between Cos2, Fu, and Ci using an in vitro affinity assay and the yeast two-hybrid system.
        
        
          Conclusions
          Our results provide new insights into the possible mechanism of the cytosolic steps of Hedgehog transduction.

Tags: cubitus-interruptus, drosophila-embryos, hedgehog-signaling, nih, signal-transduction
Organization: U.S. Department of Health & Human Services
2019 Uniform Reporting System (URS) Table for Virgin Islands

These are the 2019 Uniform Reporting System (URS) Output Tables for Virgin Islands. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, national-outcome-measures, samhsa, virgin-islands
Organization: U.S. Department of Health & Human Services
Table 4. Perceptions of Great Risk of Smoking Marijuana Once a Month among Persons Aged 12 or Older, by State and Substate Regions: Percentages, Annual Averages Based on 2008, 2009, and 2010 NSDUHs

This table presents the 2008 to 2010 National Survey on Drug Use and Health (NSDUH) estimates of perceptions of great risk of having smoking marijuana once a month among those aged 12 or older by State and substate regions.

Tags: adolescent-drug-use, marijuana-risk-perception, nsduh-data, samhsa, substance-abuse-survey
Organization: U.S. Department of Health & Human Services
Molecular determinants and regulation of Leishmania virulence

A Leishmania model to explain microbial virulence in chronic infectious diseases is proposed. All these diseases progress from infection to symptomatic phase to host death or recovery. The outcome of each phase is depicted to result from the interactions of a distinct group of parasite molecules with a specific host immune compartment. The first group consists of invasive/evasive determinants, which are largely parasite cell surface and secreted molecules. Their activities help parasites establish infection by overcoming host immunologic and non-immunologic barriers. These determinants do not cause disease per se, but are indispensable for infection necessary for the development of a disease-state. The second group of parasite molecules consists of "pathoantigenic" determinants – unique parasite epitopes present often within otherwise highly conserved cytoplasmic molecules. Immune response against these determinants is thought to result in immunopathology manifested as clinical signs or symptoms, namely the virulent phenotype. The third group of parasite molecules is hypothetically perceived as vaccine determinants. Their interactions with the host immune system lead to the elimination or reduction of parasites to effect a clinical cure. Differential expression of these determinants alone by parasites may alter their interactions with the hosts. Virulent phenotype is consequently presented as a spectrum of manifestations from asymptomatic infection to fatality. A secondary level of regulation lies in host genetic and environmental factors. The model suggests that different parasite determinants may be targeted by different strategies to achieve more effective control of leishmaniasis and other similar diseases.

Tags: immuno-pathology, infectious-disease-model, leishmania-virulence, nih, parasite-molecules
Organization: U.S. Department of Health & Human Services
Compound 528483: Docosane, 6-ethyl

Chemical compound data from PubChem database. IUPAC Name: 6-ethyldocosane. Molecular Formula: C24H50. Molecular Weight: 338.7. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2021 Treatment Episode Data Set (TEDS) Detailed Tables

The Annual Detailed Tables provide data on age, sex, race, and ethnicity of admissions to and discharges from substance use treatment services in 2021. The TEDS data set can also observe these demographic categories across National Outcome Measures (NOMs) which include stability in housing, employment status, criminal justice involvement, social support, retention in treatment, and abstinence. Data presented in the tables provide consolidated information about access to substance use treatment services across the United States, the District of Columbia, and Puerto Rico among clients aged 12 years and older in facilities that report to singe state agencies.

Tags: addiction-treatment, national-outcome-measures, samhsa, substance-use-treatment, teds-data
Organization: U.S. Department of Health & Human Services
Critical advances in septicemia and septic shock

Recent advances suggest that toll-like receptors, various cytokines, cicosanoids, free radicals and macrophage migration inhibitory factor (MIF) play an important role in the pathobiology of septicemia and septic shock. Anti-MIF antibodies can decrease the plasma concentrations of tumor necrosis factor (TNF), lower bacterial circulating counts and enhance survival of animals with septicemia and septic shock. Monocyte expression of MHC-class II antigens, neutrophil expression of the integrin CD11b/CD18 and neutrophil activation can be related to the development of, and/or recovery from, post-operative sepsis. Thus, biological variations in the response of an individual to a given stimulus, appears to determine his/her ability or inability to develop and also recover from sepsis and septic shock. This suggests that it may be possible to predict the development of septicemia and septic shock in a given individual and take appropriate action both to prevent and treat them adequately.

Tags: cytokines, nih, septic-shock, septicemia, toll-like-receptors
Organization: U.S. Department of Health & Human Services
Tribal Readiness Assessment Tool for Title IV-E (ACYF-CB-IM-22-02)

This Information Memorandum presents the Tribal Readiness Assessment Tool for the Title IV-E Program to help tribes explore areas where they have significant infrastructure in place and areas where additional capacity is needed before beginning to operate a title IV-E program.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: affair, assessment, local, scope, tool
Organization: U.S. Department of Health & Human Services
AFCARS Data Elements Side-by-Side Comparison

This is a side-by-side comparison of the AFCARS data elements published in the Appendix to 45 CFR part 1355
  
  

 and the final rule issued on December 14, 2016 (81 FR 90524
  
  

).

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: child, data, policy, regulation, reporting
Organization: U.S. Department of Health & Human Services
2011 CMHS Uniform Reporting System (URS) Output Tables for Ohio

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2011. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant, mental-health-services, outcome-measures, samhsa, urs-data
Organization: U.S. Department of Health & Human Services
Compound 528473: Decane, 2,7-dimethyl-

Chemical compound data from PubChem database. IUPAC Name: 2,7-dimethyldecane. Molecular Formula: C12H26. Molecular Weight: 170.33. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
NSDUH 2015 Data Collection Final Report

This report addresses the following topics relating to data collection for the 2015 NSDUH: Sampling and Counting and Listing Operations, Data Collection Staffing, Preparation of Survey Materials, Field Staff Training, Data Collection, Data Collection Results, and Quality Control.

Tags: data-collection-methods, nsduh-2015, quality-control, samhsa, survey-methodology
Organization: U.S. Department of Health & Human Services
Longitudinal Studies on Child Abuse and Neglect (LONGSCAN) ages 0-18

LONGSCAN is a consortium of research studies operating under common by-laws and procedures.  It was initiated in 1991 with grants from the National Center on Child Abuse and Neglect to a coordinating center at the University of North Carolina at Chapel Hill and five data collection sites.  Each site is conducting a separate and unique research project on the etiology and impact of child maltreatment.  While each project can stand on its own merits, through the use of common assessment measures, similar data collection methods and schedules, and pooled analyses, LONGSCAN is a collaborative effort that is truly greater than the sum of its parts.
     The goal of LONGSCAN is to follow the 1300+ children and their families until the children themselves become young adults.    Maltreatment data are collected from multiple sources, including review of Child Protective Service records every two years.  Yearly telephone interviews allow the sites to track families and assess yearly service utilization and important life events.
       In addition to the specific focus of the individual studies, the coordinated LONGSCAN design permits a comprehensive exploration of many critical issues in child abuse and neglect on a combined sample of sufficient size for unprecedented statistical power and flexibility.  Built into the LONGSCAN design is also the ability to replicate and extend findings across a variety of ethnic, social and economic subgroups.
    The findings of LONGSCAN will provide a scientific basis for policy-making, program planning, and targeting service delivery by increasing our understanding of the following:

Investigators: Runyan, D., Dubowitz, H., English, D., Kotch, J., Litrownik, A., & Thompson, R.

Tags: abuse, care, ndacan, policy, reporting
Organization: U.S. Department of Health & Human Services
Miami - Dade Div: Drug-Related Emergency Department Visits, 2004-2011 - Illicits (excluding alcohol)

Excel file with estimates, rates, relative standard errors, trends and confidence intervals for all drug-related emergency department (ED) visits involving illicit drugs for the Miami metropolitan area, Dade County division, covering 2004-2011. These visits involve the use of drugs that have limited or no therapeutic value and are generally illegal if taken without a prescription. It also includes visits involving the inhalation of substances for their psychoactive properties (e.g., sniffing model airplane glue).

Tags: drug-related-ed-visits, emergency-department, illicit-drug-use, miami-dade-county, samhsa
Organization: U.S. Department of Health & Human Services
Maryland (MD)

This report uses 2008 to 2010 National Survey on Drug Use and Health (NSDUH) to assess past year alcohol use disorder and illicit drug use disorder among persons aged 12 or older for Maryland overall and for substate regions within Maryland. Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE).

Tags: maryland-behavioral-health, mental-health-indicators, nsduh-data, samhsa, substance-use-disorder
Organization: U.S. Department of Health & Human Services
14th National Conference on Child Abuse and Neglect Presentation Materials

This page contains a collection of presentations and handouts from meetings, plenary and poster sessions, preconference and skills seminars, think tanks, and workshops held at the conference.

CAPTA Research Grantees’ Annual Meeting – OCAN's Grantees' Meeting Opening Session (PDF) (PDF - 60 KB), presented by Sally Flanzer, Ph.D.

The Relation of Adult Health to Adverse Childhood Experiences – Opening Plenary Keynote (PDF) (PDF - 515 KB), presented by Vincent Felitti, M.D., and Robert F. Anda, M.D.
Attachments Past and Present: Implications for the Prevention of Child Maltreatment – Plenary One Keynote (PDF) (PDF - 424 KB), presented by Byron Egeland, Ph.D.

Great Beginnings Start Before Birth: Strengthening Families through Early Prenatal Support Services and Father Involvement – Session 1 (PDF) (PDF - 40 KB), presented by Helen Reif
CAPTA Amendments 2003: How Changes in Federal Law Can Affect State Agency Programs – Session 2 (PDF) (PDF - 64 KB), Presented by Suzan Cohen

Management of Ethical Issues and Conflicts of Interest – Seminar B (PDF) (PDF - 51 KB), presented by Pamela R. Montgomery, A.C.S.W., and Elizabeth D. Still, M.A.

Child and Animal Welfare: The Roots of Collaborative Programs and Re-Emergence of Interagency and Interdisciplinary Efforts – Skills Seminar C (PDF) (PDF - 45 KB), presented by Frank R. Ascione, Ph.D., and Deborah Ascione
“The Relational Worldview:” A Tribal and Cultural Framework for Service Delivery and Program Development – Skills Seminar D (PDF) (PDF - 269 KB) Handout  (PDF)(PDF - 35 KB), presented by Andy Hunt, M.S.W., and Nadja Printup, M.S.W.
Effective Parent Leadership: A Practical Approach to Meaningful Partnerships Between Parents and Providers – Skills Seminar F (PDF) (PDF - 62 KB), presented by Teresa Rafael, M.S.W., Margaret Polinsky, Ph.D., Tanya Long, and Bunti Reed
Abuse and Neglect of Children with Disabilities: A Collaborative Response – Skills Seminar I (PDF) (PDF - 88 KB), presented by Peggy O’Neill, Brian Colligan, and Vernon Simmons
Quality Assurance, Risk Management and Documentation in the Record – Skills Seminar K (PDF) (PDF - 48 KB), presented by Bob Mitchell, A.C.S.W.
Parent Child Interaction Therapy: Training for Professionals Working with High-Risk Families – Skills Seminar M (PDF) (PDF - 3,064 KB) Handout  (PDF)(PDF - 82 KB), presented by Georganna Sedlar, Ph.D., Katherine Elliott, Ph.D., and Anthony Urquiza, Ph.D.

Formulating a Multidisciplinary Comprehensive Research Agenda for the Prevention of Child Maltreatment (PDF) (PDF - 99 KB), presented by John Holton, Kathryn Harding, Nancy Peddle
Tough Problems, Tough Choices: Casey's Guidelines for Needs-Based Service Planning in Child Welfare (PDF) (PDF - 235 KB), presented by Amy Printz Wintefeld, J.D., and Tracey Feild

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: abuse, grant, neglect, policy, real
Organization: U.S. Department of Health & Human Services
Survival of patients transferred to tertiary intensive care from rural community hospitals

Background:
          Accessibility to tertiary intensive care resources differs among hospitals within a rural region. Determining whether accessibility is associated with outcome is important for understanding the role of regionalization when providing critical care to a rural population.
        
        
          Methods:
          In a prospective design, we identified and recorded the mortality ratio, percentage of unanticipated deaths, length of stay in the intensive care unit (ICU), and survival time of 147 patients transferred directly from other hospitals and 178 transferred from the wards within a rural tertiary-care hospital.
        
        
          Results:
          The two groups did not differ significantly in the characteristics measured. Differences in access to tertiary critical care in this rural region did not affect survival or length of stay after admission to this tertiary ICU. The odds ratio (1.14; 95% confidence interval 0.72-1.83) for mortality associated with transfer from a rural community hospital was not statistically significant.
        
        
          Conclusions:
          Patients at community hospitals in this area who develop need for tertiary critical care are just as likely to survive as patients who develop ICU needs on the wards of this rural tertiary-care hospital, despite different accessibility to tertiary intensive-care services.

Tags: interhospital-transfer, mortality-rate, nih, rural-icu, survival-analysis
Organization: U.S. Department of Health & Human Services
Treatment Episode Data Set (TEDS): 1992-1997, National Admissions to Substance Abuse Treatment Services

This report presents data from the Treatment Episode Data Set (TEDS) for 1997, and trend data for 1992 to 1997. The report provides information on the demographic and substance abuse characteristics of people aged 12 and older admitted to treatment for abuse of alcohol and/or drugs in facilities that report to individual state administrative data systems.

Tags: addiction-treatment, alcohol-drug-abuse, samhsa, substance-abuse-treatment, treatment-episode-data
Organization: U.S. Department of Health & Human Services
Compound 525329: Allyl methyl tetrasulfide

Chemical compound data from PubChem database. IUPAC Name: 3-(methyltetrasulfanyl)prop-1-ene. Molecular Formula: C4H8S4. Molecular Weight: 184.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
The Paired Availability Design for Historical Controls

Background
          Although a randomized trial represents the most rigorous method of evaluating a medical intervention, some interventions would be extremely difficult to evaluate using this study design. One alternative, an observational cohort study, can give biased results if it is not possible to adjust for all relevant risk factors.
        
        
          Methods
          A recently developed and less well-known alternative is the paired availability design for historical controls. The paired availability design requires at least 10 hospitals or medical centers in which there is a change in the availability of the medical intervention. The statistical analysis involves a weighted average of a simple "before" versus "after" comparison from each hospital or medical center that adjusts for the change in availability.
        
        
          Results
          We expanded requirements for the paired availability design to yield valid inference. (1) The hospitals or medical centers serve a stable population. (2) Other aspects of patient management remain constant over time. (3) Criteria for outcome evaluation are constant over time. (4) Patient preferences for the medical intervention are constant over time. (5) For hospitals where the intervention was available in the "before" group, a change in availability in the "after group" does not change the effect of the intervention on outcome.
        
        
          Conclusion
          The paired availability design has promise for evaluating medical versus surgical interventions, in which it is difficult to recruit patients to a randomized trial.

Tags: historical-controls, medical-intervention, nih, observational-study, paired-availability-design
Organization: U.S. Department of Health & Human Services