AndreaBozzo/ceres-open-data-index huggingface dataset:
Observer variation in chest radiography of acute lower respiratory infections in children: a systematic review

Background
          Knowledge of the accuracy of chest radiograph findings in acute lower respiratory infection in children is important when making clinical decisions.
        
        
          Methods
          I conducted a systematic review of agreement between and within observers in the detection of radiographic features of acute lower respiratory infections in children, and described the quality of the design and reporting of studies, whether included or excluded from the review.
          Included studies were those of observer variation in the interpretation of radiographic features of lower respiratory infection in children (neonatal nurseries excluded) in which radiographs were read independently and a clinical population was studied. I searched MEDLINE, HealthSTAR and HSRPROJ databases (1966 to 1999), handsearched the reference lists of identified papers and contacted authors of identified studies. I performed the data extraction alone.
        
        
          Results
          Ten studies of observer interpretation of radiographic features of lower respiratory infection in children were identified. Seven of the studies satisfied four or more of the seven design and reporting criteria. Six studies met the inclusion criteria for the review. Inter-observer agreement varied with the radiographic feature examined. Kappa statistics ranged from around 0.80 for individual radiographic features to 0.27–0.38 for bacterial vs viral etiology.
        
        
          Conclusions
          Little information was identified on observer agreement on radiographic features of lower respiratory tract infections in children. Agreement varied with the features assessed from "fair" to "very good". Aspects of the quality of the methods and reporting need attention in future studies, particularly the description of criteria for radiographic features.

Tags: chest-radiography, lower-respiratory-infection, nih, observer-variation, pediatric-health
Organization: U.S. Department of Health & Human Services
FastGroup: A program to dereplicate libraries of 16S rDNA sequences

Background
          Ribosomal 16S DNA sequences are an essential tool for identifying and classifying microbes. High-throughput DNA sequencing now makes it economically possible to produce very large datasets of 16S rDNA sequences in short time periods, necessitating new computer tools for analyses. Here we describe FastGroup, a Java program designed to dereplicate libraries of 16S rDNA sequences. By dereplication we mean to: 1) compare all the sequences in a data set to each other, 2) group similar sequences together, and 3) output a representative sequence from each group. In this way, duplicate sequences are removed from a library.
        
        
          Results
          FastGroup was tested using a library of single-pass, bacterial 16S rDNA sequences cloned from coral-associated bacteria. We found that the optimal strategy for dereplicating these sequences was to: 1) trim ambiguous bases from the 5' end of the sequences and all sequence 3' of the conserved Bact517 site, 2) match the sequences from the 3' end, and 3) group sequences >=97% identical to each other.
        
        
          Conclusions
          The FastGroup program simplifies the dereplication of 16S rDNA sequence libraries and prepares the raw sequences for subsequent analyses.

Tags: 16s-rdna, bacterial-sequences, microbial-identification, nih, sequence-analysis
Organization: U.S. Department of Health & Human Services
Boston-Cambridge-Quincy, MA-NH

This report presents combined 2005 to 2010 National Survey on Drug Use and Health (NSDUH) results for those aged 12 or older in the Boston-Cambridge-Quincy, Massachusetts-New Hampshire metro area. The report includes estimates of substance use disorder, major depressive episode, illicit drug use, marijuana use, cigarette use, binge alcohol use, and the nonmedical use of prescription-type pain relievers. Results are provided for the Boston-Cambridge-Quincymetro area, Massachusetts, and the U.S. overall.

Tags: behavioral-health, mental-health, nsduh-data, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Publications Using SAMHSA Data2022 Uniform Reporting System (URS) Table For Montana

This is the 2022 Uniform Reporting System (URS) Output Tables for Montana. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-data, mental-health-services, montana-urs-data, outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Differences in time of virus appearance in the blood and virus-specific immune responses in intravenous and intrarectal primary SIV

Background
          HIV-I can be transmitted by intravenous inoculation of contaminated blood or blood product or sexually through mucosal surfaces. Here we performed a pilot study in the SIVmac251 macaque model to address whether the route of viral entry influences the kinetics of the appearance and the size of virus-specific immune in different tissue compartments.
        
        
          Methods
          For this purpose, of 2 genetically defined Mamu-A*01-positive macaques, 1 was exposed intravenously and the other intrarectally to the same SIVmac251 viral stock and virus-specific CD8+ T-cells were measured within the first 12 days of infection in the blood and at day 12 in several tissues following euthanasia.
        
        
          Results
          Virus-specific CD8+ T-cell responses to Gag, Env, and particularly Tat appeared earlier in the blood of the animal exposed by the mucosal route than in the animal exposed intravenously. The magnitude of these virus-specific responses was consistently higher in the systemic tissues and GALT of the macaque exposed by the intravenous route, suggesting a higher viral burden in the tissues as reflected by the faster appearance of virus in plasma. Differences in the ability of the virus-specific CD8+ T-cells to respond in vitro to specific peptide stimulation were also observed and the greatest proliferative ability was found in the GALT of the animal infected by the intrarectal route.
        
        
          Conclusions
          These data may suggest that the natural mucosal barrier may delay viral spreading. The consequences of this observation, if confirmed in studies with a larger number of animals, may have implications in vaccine development.

Tags: cd8-t-cells, mucosal-transmission, nih, siv-infection, viral-kinetics
Organization: U.S. Department of Health & Human Services
Illinois (IL)

This report uses 2008 to 2010 National Survey on Drug Use and Health (NSDUH) to assess past year alcohol use disorder and illicit drug use disorder among persons aged 12 or older for Illinois overall and for substate regions within Illinois. Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE).

Tags: alcohol-use-disorder, illicit-drug-use, mental-health-illinois, samhsa, substance-use-disorder
Organization: U.S. Department of Health & Human Services
Debate: Albumin administration should be avoided in the critically		  ill

The benefit of albumin administration in the critically ill patient			 is unproven. Epidemiological evidence suggests that there is an increase in			 death among patients with burns, hypoalbuminaemia, and hypotension treated with			 human albumin solution (HAS). In critical illness, hypoalbuminaemia is a result			 of transcapillary leak, decreased synthesis, large volume body fluid losses and			 dilution caused by fluid resuscitation. When treating patients with			 hypoalbuminaemia, efforts must be centred around correction of the underlying			 disorder rather than reversal of hypoalbuminaemia. Problems with using albumin			 arise because it is an expensive blood product, and can result in systemic			 changes that include cardiovascular, haematological, renal, pulmonary, and			 immunological effects.

Tags: albumin-administration, critical-illness, fluid-resuscitation, hypoalbuminemia, nih
Organization: U.S. Department of Health & Human Services
2014 CMHS Uniform Reporting System (URS) Table for North Carolina

2014 Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for North Carolina. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-data, community-mental-health, mental-health-services, noms-measures, samhsa
Organization: U.S. Department of Health & Human Services
2023 Uniform Reporting System (URS) Table For Alaska

This is the 2023 Uniform Reporting System (URS) Output Tables for Alaska. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: alaska-urs-data, block-grant-data, mental-health-services, noms-measures, samhsa
Organization: U.S. Department of Health & Human Services
2014 CMHS Uniform Reporting System (URS) Table for Tennessee

2014 Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for Tennessee. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, outcome-measures, samhsa, urs-data
Organization: U.S. Department of Health & Human Services
Drug Abuse Warning Network (DAWN): Alcohol-Related ED Visits Short Report

Drug Abuse Warning Network (DAWN): ED Visits Involving Alcohol Short Report presents the following data from January 2021-September 2023 (1) national estimates and characteristics of alcohol-related ED visits (2) demographics of alcohol-related ED visits (3) percent of ED visits related to alcohol and at least one other substance.

Tags: alcohol-co-ingestion, alcohol-related-ed-visits, emergency-department-visits, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
2022 Uniform Reporting System (URS) Table For West Virginia

This is the 2022 Uniform Reporting System (URS) Output Tables for West Virginia. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: mental-health-services, national-outcome-measures, samhsa, substance-use-treatment, west-virginia
Organization: U.S. Department of Health & Human Services
2014 CMHS Uniform Reporting System (URS) Table for Alaska

2014 Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for Alaska. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: alaska-mental-health, mental-health-services, noms-measures, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
2010 CMHS Uniform Reporting System (URS) Output Table for Ohio

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2010. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-program, community-mental-health, mental-health-services, outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
National Directory of Drug and Alcohol Abuse Treatment Facilities - 1979

The National Directory of Drug and Alcohol Abuse Treatment Programs 1979 lists federal, state, local, and private facilities that provide substance abuse treatment services. The directory includes treatment facilities that are licensed, certified, or otherwise approved for inclusion in the directory by their state substance abuse agencies and that responded to the 1978 National Survey of Substance Abuse Treatment Services (N-SSATS). The information about each facility that appears in this directory was provided by that facility in response to the 1978 N-SSATS. The Substance Abuse and Mental Health Services Administration (SAMHSA) conducts the N-SSATS annually.

Tags: alcohol-abuse-treatment, n-ssats, samhsa, substance-abuse-treatment, treatment-facilities
Organization: U.S. Department of Health & Human Services
Reactivation of a silenced

Background
          The active copy of the imprinted gene H19 is turned off by inappropriate methylation in several pediatric tumors including Wilms' Tumour and embryonal rhabdomyosarcoma. H19 controls in cis the linked Insulin-like Growth Factor 2 (IGF2) gene, encoding an important growth factor. Recent work has suggested that methylation of a gene may lead to deacetylation of its associated histones and that silenced genes can be reactivated by increasing histone acetylation levels.
        
        
          Results
          Treatment of a rhabdomyosarcoma cell line which has a silent, methylated H19 gene with histone deacetylase (HDAC) inhibitors under conditions which gave maximal hyperacetylation of histone 4, both globally and at the H19 gene itself could not reactivate H19 or affect the active Insulin-like Growth Factor 2 (IGF2) gene, but caused clear up-regulation of the Tissue-type Plasminogen Activator (TPA) gene, a non-imprinted gene known to respond to changes in histone acetylation. In contrast, mild treatment of the cells with the methylation inhibitor 5-AzaC-2'-deoxycytidine (AzaC) on its own was able to reactivate H19. Combining AzaC treatment with HDAC inhibitors gave a reduced rather than enhanced reactivation. These findings were confirmed in mouse primary liver and kidney explants which maintain normal imprinting, where we also found that the silent Igf2 gene could not be reactivated by HDAC inhibitors.
        
        
          Conclusion
          These results suggest that DNA methylation rather than histone acetylation is the primary determinant of silencing of H19 in rhabdomyosarcoma.

Tags: gene-methylation, h19-gene, hdac-inhibitors, nih, rhabdomyosarcoma
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: California, 2013

This is a behavioral health report for the state of California. It uses the  National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment Services (NSSATS) to address the topics of youth substance use , youth mental health and treatment, adult mental health and treatment, substance use, substance use treatment, for the years 2008 to 2012.

Tags: behavioral-health, california, mental-health, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
2012 State Profile - Minnesota

This is a National Survey of Substance Abuse Treatment Services (N-SSATS) annual report showing the state profile for Minnesota in 2012. N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 States, the District of Columbia, and other U.S. jurisdictions.

Tags: alcohol-drug-services, minnesota, samhsa, substance-abuse-treatment, treatment-facility-data
Organization: U.S. Department of Health & Human Services
2017 Uniform Reporting System (URS) Table for Georgia

This is the 2017 Uniform Reporting System (URS) Output Tables for Georgia. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-data, georgia-urs, mental-health-services, noms-measures, samhsa
Organization: U.S. Department of Health & Human Services
Systemic alendronate prevents resorption of necrotic bone during revascularization. A bone chamber study in rats

Background
          Avascular necrosis of bone (osteonecrosis) can cause structural failure and subsequent deformation, leading to joint dysfunction and pain. Structural failure is the result of resorption of necrotic bone during revascularization, before new bone has formed or consolidated enough for loadbearing. Bone resorption can be reduced by bisphosphonates. If resorption of the necrotic bone could be reduced during the revascularization phase until sufficient new bone has formed, it would appear that structural failure could be avoided.
        
        
          Methods
          To test whether resorption of necrotic bone can be prevented, structural grafts were subjected to new bone ingrowth during systemic bisphosphonate treatment in a rat model.
        
        
          Results
          In rats treated with alendronate the necrotic bone was not resorbed, whereas it was almost entirely resorbed in the controls.
        
        
          Conclusion
          Systemic alendronate treatment prevents resorption of necrotic bone during revascularization. In patients with osteonecrosis, bisphosphonates may therefore prevent collapse of the necrotic bone.

Tags: alendronate-treatment, bisphosphonates, bone-resorption, nih, osteonecrosis
Organization: U.S. Department of Health & Human Services
2018 Uniform Reporting System (URS) Table for North Dakota

This is the 2018 Uniform Reporting System (URS) Output Tables for North Dakota. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: behavioral-health, block-grant-data, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Region 9, Volume 6

This is a behavioral health report for HHS Region IX of the United States and utilizes data from the National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment (N-SSATS), collected annually. The topics addressed in the reports include youth substance use, adult mental health and treatment, and substance use treatment.

Tags: behavioral-health, mental-health, region-9, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Genomic comparisons among

Background
          Insertion Sequence (IS) elements are mobile genetic elements widely distributed among bacteria. Their activities cause mutations, promoting genetic diversity and sometimes adaptation. Previous studies have examined their copy number and distribution in Escherichia coli K-12 and natural isolates. Here, we map most of the IS elements in E. coli B and compare their locations with the published genomes of K-12 and O157:H7.
        
        
          Results
          The genomic locations of IS elements reveal numerous differences between B, K-12, and O157:H7. IS elements occur in hok-sok loci (homologous to plasmid stabilization systems) in both B and K-12, whereas these same loci lack IS elements in O157:H7. IS elements in B and K-12 are often found in locations corresponding to O157:H7-specific sequences, which suggests IS involvement in chromosomal rearrangements including the incorporation of foreign DNA. Some sequences specific to B are identified, as reported previously for O157:H7. The extent of nucleotide sequence divergence between B and K-12 is <2% for most sequences adjacent to IS elements. By contrast, B and K-12 share only a few IS locations besides those in hok-sok loci. Several phenotypic features of B are explained by IS elements, including differential porin expression from K-12.
        
        
          Conclusions
          These data reveal a high level of IS activity since E. coli B, K-12, and O157:H7 diverged from a common ancestor, including IS association with deletions and incorporation of horizontally acquired genes as well as transpositions. These findings indicate the important role of IS elements in genome plasticity and divergence.

Tags: bacterial-genetics, e-coli-genomes, genomic-variation, insertion-sequences, nih
Organization: U.S. Department of Health & Human Services
N-SUMHSS 2024 Questionnaire

This is the questionnaire for the 2024 National Substance Use and Mental Health Services Survey (N-SUMHSS). The N-SUMHSS is a voluntary annual survey of all active substance use and mental health facilities in the United States, its jurisdictions, and the District of Columbia. This document shows the series of questions substance use and mental health treatment facilities were asked for the N-SUMHSS.The survey consists of two introductory questions and four separate modules. Skip patterns in the survey direct participants on relevant modules depending on whether the facility is a substance use treatment facility, a mental health treatment facility, or both.Facilities operated by the Department of Veteran’s Affairs (VA) were asked to complete additional questions regarding VA services offered. Additionally, all substance use and mental health facilities were asked to complete additional questions regarding electronic health records.The questionnaire for N-SUMHSS and its supplement(s) is available as a PDF file.

Tags: health-survey, mental-health, samhsa, substance-use, treatment-facilities
Organization: U.S. Department of Health & Human Services
Seattle: Drug-Related Emergency Department Visits, 2004-2011 - Accidental Ingestions

Excel file with estimates, rates, relative standard errors, trends and confidence intervals, covering 2004-2011 for emergency department visits involving accidental ingestions in the Seattle metropolitan area. This analytic category includes ED visits in which an individual accidentally or unknowingly used or was administered a prescription drug, over-the-counter medication, or dietary supplement. Drug-related accidental ingestion typically involves patients aged 5 and under.  This analytic category does not include drug misuse or abuse.File includes data for over 500 drugs, including illicit drugs, prescription and over-the-counter medications, dietary supplements, inhalants and alcohol.  Includes total visits, gender, age group, race/ethnicity, outcome of visit, drug combinations, number of drugs involved in visit, drug frequency, and drugs confirmed by toxicology.Additional detail is provided for illicit drugs, psychotherapeutic drugs, central nervous system (CNS) drugs, respiratory drugs and cardiovascular drugs.

Tags: accidental-ingestion, drug-overdose, emergency-department, pediatric-poisoning, samhsa
Organization: U.S. Department of Health & Human Services