AndreaBozzo/ceres-open-data-index huggingface dataset:
2011 CMHS Uniform Reporting System (URS) Output Tables for Nebraska

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2011. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-program, community-mental-health, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Evaluating Systems Change: At a Glance

A supplemental resource for the evaluation brief on Evaluating Systems and Organizational Change in Child Welfare Settings, this infographic illustrates the major concepts outlined in the brief and provides quick tips for the successful evaluation of systems and organizational change efforts.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: assessment, change, child, mental, scope
Organization: U.S. Department of Health & Human Services
The genetic structure of recombinant inbred mice: high-resolution consensus maps for complex trait analysis

Background
          Recombinant inbred (RI) strains of mice are an important resource used to map and analyze complex traits. They have proved particularly effective in multidisciplinary genetic studies. Widespread use of RI strains has been hampered by their modest numbers and by the difficulty of combining results derived from different RI sets.
        
        
          Results
          We have increased the density of typed microsatellite markers two- to five-fold in each of several major RI sets that share C57BL/6 as a parental strain (AXB, BXA, BXD, BXH and CXB). A common set of 490 markers was genotyped in just over 100 RI strains. Genotypes of around 1,100 additional microsatellites in one or more RI sets were generated, collected and checked for errors. Consensus RI maps that integrate genotypes of approximately 1,600 microsatellite loci were assembled. The genomes of individual strains typically incorporate 45-55 recombination breakpoints. The collected RI set - termed the BXN set - contains approximately 5,000 breakpoints. The distribution of recombinations approximates a Poisson distribution and distances between breakpoints average about 0.5 centimorgans (cM). Locations of most breakpoints have been defined with a precision of < 2 cM. Genotypes deviate from Hardy-Weinberg equilibrium in only a small number of intervals.
        
        
          Conclusions
          Consensus maps derived from RI strains conform almost exactly to theoretical expectation and are close to the length predicted by the Haldane-Waddington equation (x3.6 for a 2-3 cM interval between markers). Non-syntenic associations between different chromosomes introduce predictable distortions in quantitative trait locus (QTL) datasets that can be partly corrected using two-locus correlation matrices.

Tags: complex-trait-analysis, microsatellite-markers, mouse-genetics, nih, recombinant-inbred-mice
Organization: U.S. Department of Health & Human Services
San Francisco – SF Div: Drug-Related Emergency Department Visits, 2004-2011 - Nonmedical Use of Pharmaceuticals

Excel file with estimates, rates, relative standard errors, trends and confidence intervals for all drug-related emergency department (ED) visits involving the nonmedical use of pharmaceuticals (prescription and over-the-counter medications and dietary supplements) for the San Francisco division of the San Francisco metropolitan area, covering 2004-2011.  Nonmedical use includes patients who took a higher than prescribed or recommended dose of their own medication, patients who took a pharmaceutical prescribed for another person, malicious poisoning of the patient by another individual, and documented substance abuse involving pharmaceuticals

Tags: drug-related-visits, emergency-department, pharmaceutical-misuse, samhsa, san-francisco
Organization: U.S. Department of Health & Human Services
Twenty-nine day study of stability for six different parenteral nutrition mixtures

Background:
          The aim of the study was to assess the particle size stability of six parenteral nutrition regimens, fitted to various pathologies, and used by the University Hospital of Limoges. The mixtures contained glucose (30 or 50%), amino acids (Hyperamine®25), and either long-chain triglycerides (20% Intralipide®) or a combination of medium and long-chain triglycerides (20% Médialipide®). The regimens were not supplemented.
        
        
          Results:
          The visual examinations, particle size analysis and physico-chemical tests, carried out during a long storage period, did not reveal any significant evolution of the lipid emulsions. All the tested formulae were stable for 28 days at 4°C plus 24 h at room temperature.
        
        
          Conclusions:
          It was concluded that the choice of lipid emulsions depends, for these formulae, on the metabolic and clinical needs of the treated patients.

Tags: amino-acids, lipid-emulsions, nih, nutrient-stability, parenteral-nutrition
Organization: U.S. Department of Health & Human Services
Boston: Drug-Related Emergency Department Visits, 2004-2011 - Nonmedical Use of Pharmaceuticals

Excel file with estimates, rates, relative standard errors, trends and confidence intervals for all drug-related emergency department (ED) visits involving the nonmedical use of pharmaceuticals (prescription and over-the-counter medications and dietary supplements) for the Boston metropolitan area, covering 2004-2011.  Nonmedical use includes patients who took a higher than prescribed or recommended dose of their own medication, patients who took a pharmaceutical prescribed for another person, malicious poisoning of the patient by another individual, and documented substance abuse involving pharmaceuticals.

Tags: boston-metro, drug-overdose, ed-visits, pharmaceutical-misuse, samhsa
Organization: U.S. Department of Health & Human Services
Treatment Episode Data Set (TEDS) 2021: Admissions To And Discharges From Substance Use Treatment Services Reported By Single State Agencies

This report presents the total number of admissions to and discharges from substance use treatment services in 2021 by demographics, National Outcome Measures (NOMs), morbidity status, and the top six primary substances by geographic distribution. The NOMs presented in this report include stability in housing, employment status, criminal justice involvement, social support, retention in treatment, and abstinence. Data include records for treatment admissions and discharges that were received and processed through October 18, 2022.

Tags: national-outcome-measures, samhsa, substance-use-treatment, teds-admissions-discharges, treatment-episode-data
Organization: U.S. Department of Health & Human Services
2016 Uniform Reporting System (URS) Table for Michigan

This is the 2016 Uniform Reporting System (URS) Output Tables for Michigan. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: mental-health-services, michigan-mental-health, national-outcome-measures, samhsa, substance-abuse-treatment
Organization: U.S. Department of Health & Human Services
2013 CMHS Uniform Reporting System (URS) Table for Montana

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Tables for Montana for 2013. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program.  State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, montana, outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Compound 528331: Isobutyl furfuryl sulfide

Chemical compound data from PubChem database. IUPAC Name: 1-(3-methylbutylsulfanylmethyl)cyclopenta-1,3-diene. Molecular Formula: C11H18S. Molecular Weight: 182.33. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Assessment of performance of four mortality prediction systems in a Saudi Arabian intensive care unit

Introduction
          The purpose of this study is to assess the performance of Acute Physiology and Chronic Health Evaluation (APACHE) II, Simplified Acute Physiology Score (SAPS) II, Mortality Probability Model MPM II0 and MPM II24 systems in a major tertiary care hospital in Riyadh, Saudi Arabia.
        
        
          Methods
          The following data were collected prospectively on all consecutive patients admitted to the Intensive Care Unit between 1 March 1999 and 31 December 2000: demographics, APACHE II and SAPS II scores, MPM variables, ICU and hospital outcome. Predicted mortality was calculated using original regression formulas. Standardized mortality ratio (SMR) was computed with 95% confidence intervals (CI). Calibration was assessed by calculating Lemeshow–Hosmer goodness-of-fit C statistics. Discrimination was evaluated by calculating the Area Under the Receiver Operating Characteristic Curves (ROC AUC).
        
        
          Results
          Predicted mortality by all systems was not significantly different from actual mortality [SMR for MPM II0: 1.00 (0.91–1.10), APACHE II: 1.00 (0.8–1.11), SAPS II: 1.09 (0.97–1.21), MPM II24 0.92 (0.82–1.03)]. Calibration was best for MPM II24 (C-statistic: 14.71, P = 0.06). Discrimination was best for MPM II0 (ROC AUC:0.85) followed by MPM II24 (0.84), APACHE II (0.83) then SAPS II (0.79).
        
        
          Conclusions
          In our ICU population: 1) Overall mortality prediction, estimated by standardized mortality ratio, was accurate, especially for MPM II0 and APACHE II. 2) MPM II24 has the best calibration. 3) SAPS II has the lowest calibration and discrimination. The local performance of MPM II24 in addition to its ease-to-use makes it an attractive model for mortality prediction in Saudi Arabia.

Tags: apache-ii, icu-mortality, mortality-prediction, nih, saps-ii
Organization: U.S. Department of Health & Human Services
The velocity of ultrasound in human primary melanoma tissue - implications for the clinical use of high resolution sonography

Background
          Ultrasonography with 20 MHz frequency can be used to estimate tumour thickness preoperatively in malignant melanoma (MM) of the skin. The vertical invasion depth is the single most important prognostic factor for localised MM, and its preoperative knowledge would be very useful for the planning of surgical procedures. Since ultrasonographic distance measurements directly depend upon the tissue specific ultrasound velocity, we determined the ultrasound velocity in primary melanoma.
        
        
          Results
          Ultrasound velocity was calculated from runtime differences of a 20 MHz ultrasound signal along a known distance either through water alone or through thick specimens of primary MM. The ultrasound velocities varied between 1553 m/s and 1588 m/s with a mean of 1564 m/s in four different MM specimens. The analysis of different parts of the specimens showed that the variation of the calculated velocities was larger between different specimens than within one individual specimen.
        
        
          Conclusions
          The ultrasound velocity in MM tissue may be slightly lower than normally assumed, thereby explaining a part of the overestimation usually found in sonographic measurement of melanoma invasion depth. Additionally, the variation of ultrasound velocity between individual tumours may contribute to the impairment of the correlation found between sonometry and Breslow's measurement of MM invasion depth. For practical reasons, a setting of 1580 m/s will be appropriate for ultrasonography of primary malignant melanoma.

Tags: high-resolution-sonography, melanoma-tissue, nih, tumor-thickness, ultrasound-velocity
Organization: U.S. Department of Health & Human Services
2010 National Survey of Substance Abuse Treatment Services (N-SSATS) Census Regional Report

This is a National Survey of Substance Abuse Treatment Services (N-SSATS) Census regional report that focuses on the rate of clients in treatment for substance abuse in 2010. There are 9 U.S. Census  regional  divisions. The National Survey of Substance Abuse Treatment Services (N-SSATS) is an annual census of facilities in the United States, both public and private, that provide substance abuse treatment.

Tags: n-ssats, regional-data, samhsa, substance-abuse-treatment, treatment-census
Organization: U.S. Department of Health & Human Services
TEDS 2010 Discharges

This annual report presents data for 2010 from the Treatment Episode Data Set (TEDS) on the demographic and substance abuse characteristics of substance abuse treatment discharges aged 12 and older in facilities that report to individual State administrative data systems.

Tags: addiction-treatment, samhsa, substance-abuse-treatment, substance-use-disorder, teds-discharges
Organization: U.S. Department of Health & Human Services
High-throughput genotyping of single nucleotide polymorphisms with rolling circle amplification

Background
          Single nucleotide polymorphisms (SNPs) are the foundation of powerful complex trait and pharmacogenomic analyses. The availability of large SNP databases, however, has emphasized a need for inexpensive SNP genotyping methods of commensurate simplicity, robustness, and scalability.
          We describe a solution-based, microtiter plate method for SNP genotyping of human genomic DNA. The method is based upon allele discrimination by ligation of open circle probes followed by rolling circle amplification of the signal using fluorescent primers. Only the probe with a 3' base complementary to the SNP is circularized by ligation.
        
        
          Results
          SNP scoring by ligation was optimized to a 100,000 fold discrimination against probe mismatched to the SNP. The assay was used to genotype 10 SNPs from a set of 192 genomic DNA samples in a high-throughput format. Assay directly from genomic DNA eliminates the need to preamplify the target as done for many other genotyping methods. The sensitivity of the assay was demonstrated by genotyping from 1 ng of genomic DNA. We demonstrate that the assay can detect a single molecule of the circularized probe.
        
        
          Conclusions
          Compatibility with homogeneous formats and the ability to assay small amounts of genomic DNA meets the exacting requirements of automated, high-throughput SNP scoring.

Tags: genomic-dna, nih, pharmacogenomics, rolling-circle-amplification, snp-genotyping
Organization: U.S. Department of Health & Human Services
Compound 527242: Tricyclovetivenol

Chemical compound data from PubChem database. IUPAC Name: (7,7-dimethyl-6-methylidene-2-tricyclo[6.2.1.01,5]undecanyl)methanol. Molecular Formula: C15H24O. Molecular Weight: 220.35. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Minneapolis: Drug-Related Emergency Department Visits, 2004-2011 - Illicits (excluding alcohol)

Excel file with estimates, rates, relative standard errors, trends and confidence intervals for all drug-related emergency department (ED) visits involving illicit drugs for the Minneapolis metropolitan area, covering 2004-2011. These visits involve the use of drugs that have limited or no therapeutic value and are generally illegal if taken without a prescription. It also includes visits involving the inhalation of substances for their psychoactive properties (e.g., sniffing model airplane glue).

Tags: drug-related-ed-visits, emergency-department, illicit-drug-use, minneapolis, samhsa
Organization: U.S. Department of Health & Human Services
Research Article: BMC Genetics

Background
          Glucose repression of transcription in the yeast, Saccharomyces cerevisiae, has been shown to be controlled by several factors, including two repressors called Mig1 and Mig2. Past results suggest that other repressors may be involved in glucose repression.
        
        
          Results
          By a screen for factors that control transcription of the glucose-repressible SUC2 gene of S. cerevisiae, the NRG1 gene was identified. Analysis of an nrg1Δ mutant has demonstrated that mRNA levels are elevated at both the SUC2 and of the GAL genes of S. cerevisiae when cells are grown under normally glucose-repressing conditions. In addition, genetic interactions have been detected between nrg1Δ and other factors that control SUC2 transcription.
        
        
          Conclusions
          The analysis of nrg1Δ demonstrates that Nrg1 plays a role in glucose repression of the SUC2 and GAL genes of S. cerevisiae. Thus, three repressors, Nrg1, Mig1, and Mig2, are involved as the downstream targets of the glucose signaling in S. cerevisiae.

Tags: gene-transcription, glucose-repression, nih, saccharomyces-cerevisiae
Organization: U.S. Department of Health & Human Services
A Day in the Life of American Adolescents: Substance Use Facts Update

This short report uses data from the 2010 and 2011 National Surveys on Drug Use and Health (NSDUHs), the 2010 Treatment Episode Data Set (TEDS), the 2010 National Survey of Substance Abuse Treatment Services (N-SSATS), and the 2011 Drug Abuse Warning Network (DAWN) to present facts about adolescent substance use, including information on the initiation of substance use, past year substance use, emergency department visits, and receipt of substance use treatment.

Tags: adolescent-substance-use, drug-abuse-trends, emergency-department-visits, samhsa, substance-use-treatment
Organization: U.S. Department of Health & Human Services
A novel tetratricopeptide repeat (TPR) containing PP5 serine/threonine protein phosphatase in the malaria parasite,

Background
          The malarial parasite, Plasmodium falciparum (Pf), is responsible for nearly 2 million deaths worldwide. However, the mechanisms of cellular signaling in the parasite remain largely unknown. Recent discovery of a few protein kinases and phosphatases point to a thriving reversible phosphorylation system in the parasite, although their function and regulation need to be determined.
        
        
          Results
          We provide biochemical and sequence evidence for a protein serine/threonine phosphatase type PP5 in Plasmodium falciparum, and named it PfPP5. The 594-amino acid polypeptide was encoded by a 1785 nucleotide long intronless gene in the parasite. The recombinant protein, expressed in bacteria, was indistinguishable from native PfPP5. Sequencing comparison indicated that the extra-long N-terminus of PfPP5 outside the catalytic core contained four tetratricopeptide repeats (TPRs), compared to three such repeats in other PP5 phosphatases. The PfPP5 N-terminus was required for stimulation of the phosphatase activity by polyunsaturated fatty acids. Co-immunoprecipitation demonstrated an interaction between native PfPP5 and Pf heat shock protein 90 (hsp90). PfPP5 was expressed in all the asexual erythrocytic stages of the parasite, and was moderately sensitive to okadaic acid.
        
        
          Conclusions
          This is the first example of a TPR-domain protein in the Apicomplexa family of parasites. Since TPR domains play important roles in protein-protein interaction, especially relevant to the regulation of PP5 phosphatases, PfPP5 is destined to have a definitive role in parasitic growth and signaling pathways. This is exemplified by the interaction between PfPP5 and the cognate chaperone hsp90.

Tags: malaria-research, nih, pfpp5-phosphatase, plasmodium-falciparum, protein-phosphatase
Organization: U.S. Department of Health & Human Services
Compound 527355: 16,20-Dimethyl-triacontyl cyanide

Chemical compound data from PubChem database. IUPAC Name: 17,21-dimethylhentriacontanenitrile. Molecular Formula: C33H65N. Molecular Weight: 475.9. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
CD26 immuno-expression and periodontal disease progression

Immunological mechanisms participate in the pathogenesis of human chronic inflammatory periodontal disease (CIPD). Human CD4+
lymphocytes express functionally heterogeneous profiles of cytokine production. CD26 is an integral membrane glycoprotein, that is, a marker of Th1-like cytokine development. The purpose of the present study was to compare the immuno-expression of CD26 receptor in periodontal sites with and without clinical attachment loss (CAL). Five patients with rapidly progressing
periodontitis and one with juvenile periodontitis were investigated. Each patient presented at least one site with and without CAL. Ten sites with CAL and nine without any CAL were biopsied, followed by the immunohistochemical identification of the CD26 receptor using the MIB-DS2/7 antibody. The results
demonstrated that the percentage of positive cells for this antigen in the periodontal sites with CAL was not significantly different from those without attachment loss. Therefore, Th1 cell impairment may not be directly involved with periodontal attachment loss.

Tags: cd26-expression, clinical-attachment-loss, immunohistochemistry, nih, periodontal-disease
Organization: U.S. Department of Health & Human Services