AndreaBozzo/ceres-open-data-index huggingface dataset:
Insights into rheumatoid arthritis derived from the Sa immune system

The Sa system is a recently described immune system that has a specificity and positive predictive value of nearly 100% for rheumatoid arthritis (RA) in Asia, Europe and the Americas. Its sensitivity of 30-40% suggests that it identifies a subset of RA patients. Anti-Sa antibodies are present from disease onset and are predictive of disease severity. The immune reactants are plentiful in the target tissue: antigen is present in the synovium, IgG antibody in the fluid. Immunologically, Sa is a hapten-carrier antigen in which vimentin is the carrier and citrulline is the hapten. The citrullination of vimentin is closely related to apoptosis, and citrullinated vimentin is extremely sensitive to digestion by the ubiquitous calpains. Nevertheless, Sa is found in only a few cell lines. Calpastatin, the natural specific inhibitor of calpains, is also a RA-associated, albeit non-specific, autoimmune system. Is it possible that calpain-related apoptotic pathways could be prominent in cells containing Sa? The task is to reconcile the specificity of Sa/citrullinated proteins in a multifactorial and polygenic disease such as RA.

Tags: anti-sa-antibodies, autoimmune-disease, citrullinated-vimentin, nih, rheumatoid-arthritis
Organization: U.S. Department of Health & Human Services
Compound 528573: tert-Butyl(dimethyl)silyl laurate

Chemical compound data from PubChem database. IUPAC Name: [tert-butyl(dimethyl)silyl] dodecanoate. Molecular Formula: C18H38O2Si. Molecular Weight: 314.6. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Dynamic compression nail: A preliminary report

Background
          Interlocking nailing, which has become the method of choice for treating fractures of the femoral and tibial shafts, still lacks ability to provide the important contact-compression at the fracture. An intramedullary compression nail is described, which provides axial compression at the fracture site with tightening of the specially designed distal interlocking screw. This uses the same principle as dynamic compression plating.
        
        
          Methods
          The study included 11 femoral and tibial nailings performed for various clinical applications such as acute fractures, non-unions and malunions.
        
        
          Results
          All the fractures attained radiological union, with good skeletal continuity across the fracture, within an average time of 13 weeks in fresh fractures and 18 weeks in non-unions.
        
        
          Conclusions
          Active compression through intramedullary compression nailing has great utility for treating non-unions where it provides greater degree of impaction of its irregular ends. This may prove greatly advantageous to the fracture union through increased stability and the osteogenic potential, particularly when utilized in combination with the small diameter unreamed nails.

Tags: bone-union, femoral-fracture, fracture-fixation, intramedullary-nailing, nih
Organization: U.S. Department of Health & Human Services
Analysis of human sarcospan as a candidate gene for CFEOM1

Background
          Congenital fibrosis of the extraocular muscles type 1 (CFEOM1) is an autosomal dominant eye movement disorder linked to the pericentromere of chromosome 12 (12p11.2 - q12). Sarcospan is a member of the dystrophin associated protein complex in skeletal and extraocular muscle and maps to human chromosome 12p11.2. Mutations in the genes encoding each of the other components of the skeletal muscle sarcospan-sarcoglycan complex (α - δ sarcoglycan) have been shown to cause limb girdle muscular dystrophy (LGMD2C-F). To determine whether mutations in the sarcospan gene are responsible for CFEOM1 we: (1) attempted to map sarcospan to the CFEOM1 critical region; (2) developed a genomic primer set to directly sequence the sarcospan gene in CFEOM1 patients; and (3) generated an anti-sarcospan antibody to examine extraocular muscle biopsies from CFEOM1 patients.
        
        
          Results
          When tested by polymerase chain reaction, sarcospan sequence was not detected on yeast or bacterial artificial chromosomes from the CFEOM1 critical region. Sequencing of the sarcospan gene in CFEOM1 patients from 6 families revealed no mutations. Immunohistochemical studies of CFEOM1 extraocular muscles showed normal levels of sarcospan at the membrane. Finally, sarcospan was electronically mapped to bacterial artificial chromosomes that are considered to be outside of the CFEOM1 critical region.
        
        
          Conclusions
          In this report we evaluate sarcospan as a candidate gene for CFEOM1. We have found that it is highly unlikely that sarcospan is involved in the pathogenesis of this disease. As of yet no sarcospan gene mutations have been found to cause muscular abnormalities.

Tags: cfeom1, extraocular-muscle, eye-movement-disorder, nih, sarcospan-gene
Organization: U.S. Department of Health & Human Services
A new device for measurement of fibrin clot lysis: application to the Euglobulin Clot Lysis Time

Background
          Determination of clot lysis times on whole blood, diluted whole blood, plasma or plasma fraction has been used for many years to assess the overall activity of the fibrinolytic system. We designed a completely computerised semi-automatic 8-channel device for measurement and determination of fibrin clot lysis. The lysis time is evaluated by a mathematical analysis of the lysis curve and the results are expressed in minute (range: 5 to 9999). We have used this new device for Euglobulin Clot Lysis Time (ECLT) determination, which is the most common test used in laboratories to estimate plasma fibrinolytic capacity.
        
        
          Results
          The correlation between ECLT and manual method is very tight : R = 0,99; p < 10-6. The efficiency scores of the method are <4% in intra-assay and <7% in inter-assay. It allows to achieve the tests on hyperlipaemic samples. This new device has been easily integrated in laboratory routine and allows to achieve several ECLT every day without disturbance of laboratory workflow.
        
        
          Conclusions
          The routine use of this new device could be useful in various situations such as assessment in atherosclerosis and arteriosclerosis associated diseases, coagulation survey of liver transplantations, cardiovascular surgery or pharmacological research.
          It has already provided highly promising results in preliminary studies on the relation between fibrinolysis and cardiovascular risk factors.

Tags: clot-lysis-time, euglobulin-clot-lysis, fibrin-clot-lysis, fibrinolytic-system, nih
Organization: U.S. Department of Health & Human Services
4.15b Facility licensing, certification, or accreditation, by facility operation and primary focus of facility: 2011. Percent

This is a National Survey of Substance Abuse Treatment Services (N-SSATS) data table showing facility licensing, certification, or accreditation, by facility operation and primary focus of facility in 2011. N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 States, the District of Columbia, and other U.S. jurisdictions.

Tags: accreditation, facility-licensing, n-ssats, samhsa, substance-abuse-treatment
Organization: U.S. Department of Health & Human Services
2023 Uniform Reporting System (URS) Table For Utah

This is the 2023 Uniform Reporting System (URS) Output Tables for Utah. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: mental-health-services, national-outcome-measures, samhsa, substance-abuse, utah-mental-health
Organization: U.S. Department of Health & Human Services
Child Welfare Outcomes 2017: Report to Congress

This report to Congress provides information on the performance of states on seven national outcome categories and also includes data on contextual factors and findings of analyses conducted across states.

(PDF  (PDF)- 4,518KB)

(PDF (PDF) - 945KB)

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Executive Summary

Contextual Factors

State Performance on Outcome Measures

Conclusion and Recommendations for Further Investigation

Child Welfare Outcomes Data Site

Introduction to the Child Welfare Outcomes, Data, and Analysis

Outcome Measures

Context Data

Data Sources

Data Analyses in the Report

The Child Welfare Outcomes Report Data Site

Chapter 1: Child Welfare Outcomes Demographic Data

National Child Population

Children in Foster Care

Foster Care Entry Rates

Children Waiting for Adoption and Children Adopted

Summary

Chapter 2: Keeping Children Safe

Child Victims and Child Fatalities

Range of State Performance on Safety-Related Outcome Measures

Changes Over Time in State Performance on Measures of Maltreatment Recurrence and Maltreatment of Children in Foster Care

Summary of Findings Regarding Keeping Children Safe

Chapter 3: Finding Permanent Homes for Children in Foster Care

Range of Performance in Achieving Permanency for Children in Foster Care

Changes Over Time in State Performance on Measures of Achieving Permanency

Summary of Findings Regarding Achieving Permanency for Children in Foster Care

Chapter 4: Achieving Timely Reunifications and Adoptions for Children in Foster Care

Caseworker Visits

Timeliness of Reunifications

Changes Over Time in State Performance With Regard to Achieving Timely Reunifications

Timeliness of Adoptions

Changes Over Time in State Performance With Regard to Timeliness of Adoptions

Summary of Findings Regarding Achieving Reunifications and Adoptions in a Timely Manner

Chapter 5: Achieving Stable and Appropriate Placement Settings for Children in Foster Care

Changes Over Time in State Performance on Measures of Achieving Stable and Appropriate Placement Settings for Children in Foster Care

Summary of Findings Regarding Achieving Stable and Appropriate Placements for Children in Foster Care

Chapter 6: State Comments on Performance Relevant to the Seven National Child Welfare Outcomes

Appendix A: Adoption and Safe Families Act of 1997 (Pub. L. 105—89)

Appendix B: Child Welfare Outcomes Report: Outcomes and Measures

Appendix C: Caseworker Visits

Appendix D: Child Welfare Outcomes Report: Data Sources and Elements

Appendix E: Child Maltreatment 2017: Summary of Key Findings

Appendix F: The AFCARS Report: FY 2017 Estimates

Appendix G: Data-Quality Criteria

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: assessment, child, policy, reporting, scope
Organization: U.S. Department of Health & Human Services
Assessing the Relationship Between Interviewer Effects and NSDUH Data Quality

This National Survey on Drug Use and Health (NSDUH) methodological report presents analyzes the relationships between several field interviewer characteristics and various survey outcomes, including response rates and respondent self-reports on substance use and mental health indicators.

Tags: data-quality, interviewer-effects, mental-health, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Victimization and Other Risk Factors for Child Maltreatment Among School-Age Parents: A Longitudinal Study, 1988- 1992

This descriptive longitudinal field study looks at risk factors in the etiology of child abuse and neglect among adolescent parents. The investigators examined sexual victimization prior to pregnancy as a major antecedent factor for child maltreatment. Pregnant and/or parenting adolescents were recruited from ongoing educational and social programs in the state of Washington between October 1988 and 1989. The sample consisted of 535 adolescent females who were 17 years old or younger at the time of their first pregnancy, and 21 years old or younger at the time they completed the survey. Follow-up data for this study were collected on 315 of these females between 1990 and 1991. The survey data describe respondents demographic characteristics, family background, pregnancies, parenting history, sexual histories, behavioral indicators of sexual victimization, physical maltreatment, and neglect. In addition, data were collected on parenting skills, attitudes, social support, sex roles and attitudes toward sexual activity. The data allow for examination of the inter-relationship between:  1) childhood sexual abuse, 2) adolescent pregnancy, and 3) child maltreatment by adolescent parents. The Archive distributes two data files for this study.  One file contains the baseline data collected between 1988 and 1989 for all 540 participants in wave one.  The second data file includes baseline and follow-up data for the 318 women who participated in both waves of the study.

Investigators: Boyer, D., & Fine, D.

Tags: abuse, care, ndacan, policy, reporting
Organization: U.S. Department of Health & Human Services
2010 CMHS Uniform Reporting System (URS) Output Tables for Minnesota

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2010. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, national-outcome-measures, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
Gene expression profile of HIV-1 Tat expressing cells: a close interplay between proliferative and differentiation signals

Background
          Expression profiling holds great promise for rapid host genome functional analysis. It is plausible that host expression profiling in an infection could serve as a universal phenotype in virally infected cells. Here, we describe the effect of one of the most critical viral activators, Tat, in HIV-1 infected and Tat expressing cells. We utilized microarray analysis from uninfected, latently HIV-1 infected cells, as well as cells that express Tat, to decipher some of the cellular changes associated with this viral activator.
        
        
          Results
          Utilizing uninfected, HIV-1 latently infected cells, and Tat expressing cells, we observed that most of the cellular host genes in Tat expressing cells were down-regulated. The down-regulation in Tat expressing cells is most apparent on cellular receptors that have intrinsic receptor tyrosine kinase (RTK) activity and signal transduction members that mediate RTK function, including Ras-Raf-MEK pathway. Co-activators of transcription, such as p300/CBP and SRC-1, which mediate gene expression related to hormone receptor genes, were also found to be down-regulated. Down-regulation of receptors may allow latent HIV-1 infected cells to either hide from the immune system or avoid extracellular differentiation signals. Some of the genes that were up-regulated included co-receptors for HIV-1 entry, translation machinery, and cell cycle regulatory proteins.
        
        
          Conclusions
          We have demonstrated, through a microarray approach, that HIV-1 Tat is able to regulate many cellular genes that are involved in cell signaling, translation and ultimately control the host proliferative and differentiation signals.

Tags: gene-expression, hiv-1, nih, rtk-signaling, tat-protein
Organization: U.S. Department of Health & Human Services
Assessing the quality of reports of systematic reviews in pediatric complementary and alternative medicine

Objective
          To examine the quality of reports of complementary and alternative medicine (CAM) systematic reviews in the pediatric population. We also examined whether there were differences in the quality of reports of a subset of CAM reviews compared to reviews using conventional interventions.
        
        
          Methods
          We assessed the quality of reports of 47 CAM systematic reviews and 19 reviews evaluating a conventional intervention. The quality of each report was assessed using a validated 10-point scale.
        
        
          Results
          Authors were particularly good at reporting: eligibility criteria for including primary studies, combining the primary studies for quantitative analysis appropriately, and basing their conclusions on the data included in the review. Reviewers were weak in reporting: how they avoided bias in the selection of primary studies, and how they evaluated the validity of the primary studies. Overall the reports achieved 43% (median = 3) of their maximum possible total score. The overall quality of reporting was similar for CAM reviews and conventional therapy ones.
        
        
          Conclusions
          Evidence based health care continues to make important contributions to the well being of children. To ensure the pediatric community can maximize the potential use of these interventions, it is important to ensure that systematic reviews are conducted and reported at the highest possible quality. Such reviews will be of benefit to a broad spectrum of interested stakeholders.

Tags: alternative-medicine, nih, pediatric-cam, research-bias, systematic-review-quality
Organization: U.S. Department of Health & Human Services
Upregulation of the SERCA-type Ca

Background
          Ca2+-ATPases of endoplasmic reticulum (SERCAs) are responsible for maintenance of the micro- to millimolar Ca2+ ion concentrations within the endoplasmic reticulum (ER) of eukaryotic cells. This intralumenal Ca2+ storage is important for the generation of Ca2+ signals as well as for the correct folding and posttranslational processing of proteins entering ER after synthesis. ER perturbations such as depletion of Ca2+ or abolishing the oxidative potential, inhibition of glycosylation, or block of secretory pathway, activate the Unfolded Protein Response, consisting of an upregulation of a number of ER-resident chaperones/stress proteins in an effort to boost the impaired folding capacity.
        
        
          Results
          We show here that in PC12 cells, depletion of ER Ca2+ by EGTA, as well as inhibition of disulphide bridge formation within the ER by dithiotreitol or inhibition of N-glycosylation by tunicamycin, led to a 2- to 3-fold increase of the SERCA-mediated 45Ca2+ transport to microsomes isolated from cells exposed to these stress agents. The time course of this response corresponded to that for transcriptional upregulation of ER stress proteins, as well as to the increase in the SERCA2b mRNA, as we recently observed in an independent study.
        
        
          Conclusions
          These findings provide the first functional evidence for the increase of SERCA pumping capacity in cells subjected to the ER stress. Since at least three different and unrelated mechanisms of eliciting the ER stress response were found to cause this functional upregulation of Ca2+ transport into the ER, these results support the existence of a coupling between the induction of the UPR pathway in general, and the regulation of expression of at least one of the SERCA pump isoforms.

Tags: calcium-regulation, endoplasmic-reticulum, nih, protein-folding, serca-atpases
Organization: U.S. Department of Health & Human Services
Compound 525417: 2-Methyl-4-thianonane

Chemical compound data from PubChem database. IUPAC Name: 1-(2-methylpropylsulfanyl)pentane. Molecular Formula: C9H20S. Molecular Weight: 160.32. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Pennsylvania (PA)

This report uses 2008 to 2010 National Survey on Drug Use and Health (NSDUH) to assess past year alcohol use disorder and illicit drug use disorder among persons aged 12 or older for Pennsylvania overall and for substate regions within Pennsylvania. Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE).

Tags: mental-health-indicators, nsduh-data, pennsylvania, samhsa, substance-use-disorder
Organization: U.S. Department of Health & Human Services
2020 Uniform Reporting System (URS) Table For American Samoa

This is the 2020 Uniform Reporting System (URS) Output Tables for American Samoa. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: american-samoa, mental-health-services, noms-measures, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
Table 14. Tobacco Product Use in the Past Month among Persons Aged 12 or Older, by State and Substate Regions: Percentages, Annual Averages Based on 2008, 2009, and 2010 NSDUHs

This table presents the 2008 to 2010 National Survey on Drug Use and Health (NSDUH) estimates of past month tobacco use by those aged 12 or older by State and substate regions.

Tags: nsduh-data, samhsa, substate-data, tobacco-use, youth-tobacco
Organization: U.S. Department of Health & Human Services
Practical Guidance to Developing Comprehensive Child Welfare Information System (CCWIS) Advance Planning Documents

This webinar summarized the different Advance Planning Documents (Planning, Implementation, Annual, As-Needed, and Operational) and then advised how to compose quality Advance Planning Documents.  This webinar included suggestions to save time and simplify the process, and tips on dos and don'ts that affect approval.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: child, guidance, instruction, policy, system
Organization: U.S. Department of Health & Human Services
Epithelial antimicrobial peptides in host defense against infection

One component of host defense at mucosal surfaces seems to be epithelium-derived antimicrobial peptides. Antimicrobial peptides are classified on the basis of their structure and amino acid motifs. Peptides of the defensin, cathelicidin, and histatin classes are found in humans. In the airways, α-defensins and the cathelicidin LL-37/hCAP-18 originate from neutrophils. β-Defensins and LL-37/hCAP-18 are produced by the respiratory epithelium and the alveolar macrophage and secreted into the airway surface fluid. Beside their direct antimicrobial function, antimicrobial peptides have multiple roles as mediators of inflammation with effects on epithelial and inflammatory cells, influencing such diverse processes as proliferation, immune induction, wound healing, cytokine release, chemotaxis, protease-antiprotease balance, and redox homeostasis. Further, antimicrobial peptides qualify as prototypes of innovative drugs that might be used as antibiotics, anti-lipopolysaccharide drugs, or modifiers of inflammation.

Tags: antimicrobial-peptides, defensins, host-defense, mucosal-immunity, nih
Organization: U.S. Department of Health & Human Services