AndreaBozzo/ceres-open-data-index huggingface dataset:
The impact of incident vertebral and non-vertebral fractures on health related quality of life in postmenopausal women

Background
          Little empirical research has examined the multiple consequences of osteoporosis on quality of life.
        
        
          Methods
          Health related quality of life (HRQL) was examined in relationship to incident fractures in 2009 postmenopausal women 50 years and older who were seen in consultation at our tertiary care, university teaching hospital-affiliated office and who were registered in the Canadian Database of Osteoporosis and Osteopenia (CANDOO) patients. Patients were divided into three study groups according to incident fracture status: vertebral fractures, non-vertebral fractures and no fractures. Baseline assessments of anthropometric data, medical history, therapeutic drug use, and prevalent fracture status were obtained from all participants. The disease-targeted mini-Osteoporosis Quality of Life Questionnaire (mini-OQLQ) was used to measure HRQL.
        
        
          Results
          Multiple regression analyses revealed that subjects who had experienced an incident vertebral fracture had lower HRQL difference scores as compared with non-fractured participants in total score (-0.86; 95% confidence intervals (CI): -1.30, -0.43) and the symptoms (-0.76; 95% CI: -1.23, -0.30), physical functioning (-1.12; 95% CI: -1.57, -0.67), emotional functioning (-1.06; 95% CI: -1.44, -0.68), activities of daily living (-1.47; 95% CI: -1.97, -0.96), and leisure (-0.92; 95% CI: -1.37, -0.47) domains of the mini-OQLQ. Patients who experienced an incident non-vertebral fracture had lower HRQL difference scores as compared with non-fractured participants in total score (-0.47; 95% CI: -0.70, -0.25), and the symptoms (-0.25; 95% CI: -0.49, -0.01), physical functioning (-0.39; 95% CI: -0.65, -0.14), emotional functioning (-0.97; 95% CI: -1.20, -0.75) and the activities of daily living (-0.47; 95% CI: -0.73, -0.21) domains.
        
        
          Conclusion
          Quality of life decreased in patients who sustained incident vertebral and non-vertebral fractures.

Tags: nih, osteoporosis, postmenopausal-women, quality-of-life, vertebral-fractures
Organization: U.S. Department of Health & Human Services
2012 State Profile - Vermont

This is a National Survey of Substance Abuse Treatment Services (N-SSATS) annual report showing the state profile for Vermont in 2012. N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 States, the District of Columbia, and other U.S. jurisdictions.

Tags: alcohol-drug-services, n-ssats, samhsa, substance-abuse-treatment, vermont
Organization: U.S. Department of Health & Human Services
Diclofenac does not interact with codeine metabolism in vivo: A study in healthy volunteers

Background
          Previously, we have demonstrated a marked inhibition of codeine glucuronidation by diclofenac in human liver tissue homogenate. We therefore aimed to investigate whether diclofenac inhibits glucuronidation of codeine also in vivo in healthy volunteers.
        
        
          Methods
          In a randomised, placebo-controlled, double-blind, cross-over study, 12 healthy volunteers received a singe of 100 mg codeine phosphate plus 50 mg diclofenac sodium or codeine phosphate plus placebo. Over a 36 hour period serum concentrations of codeine and its metabolites as well as urinary excretion were analysed using LC-mass spectrometry. Side effects were recorded and analgesic efficacy was determined using the cold pressor test (0–6 h).
        
        
          Results
          A single dose of diclofenac did not alter the formation of codeine-6-glucuronide in healthy volunteers. Metabolic clearance of codeine to morphine was not affected by diclofenac. In terms of side effects, both treatments were well tolerated. Diclofenac did not significantly influence the analgesic effects of codeine in the cold pressor test.
        
        
          Conclusions
          In contrast to recent in vitro data, a single oral dose of diclofenac did not alter the glucuronidation of codeine in healthy volunteers.

Tags: analgesic-efficacy, codeine-metabolism, diclofenac-interaction, healthy-volunteers, nih
Organization: U.S. Department of Health & Human Services
Compound 527357: 18,22,26,30-Tetramethyl-tritriacontyl cyanide

Chemical compound data from PubChem database. IUPAC Name: 19,23,27,31-tetramethyltetratriacontanenitrile. Molecular Formula: C38H75N. Molecular Weight: 546.0. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Publications Using SAMHSA Data2015 CMHS Uniform Reporting System (URS) Table for Michigan

2015 Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for Michigan. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: mental-health-services, michigan-mental-health, national-outcome-measures, samhsa, urs-data
Organization: U.S. Department of Health & Human Services
Compound 528376: Pentane, 2,4-dimethyl-3-methylene-

Chemical compound data from PubChem database. IUPAC Name: 2,4-dimethyl-3-methylidenepentane. Molecular Formula: C8H16. Molecular Weight: 112.21. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2022 Uniform Reporting System (URS) Table For Wyoming

This is the 2022 Uniform Reporting System (URS) Output Tables for Wyoming. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: behavioral-health, community-mental-health, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
A comparison of volume control and pressure-regulated volume control ventilation in acute respiratory failure

Background:
          The aim of this study was to test the hypothesis that a new mode of ventilation (pressure-regulated volume control; PRVC) is associated with improvements in respiratory mechanics and outcome when compared with conventional volume control (VC) ventilation in patients with acute respiratory failure. We conducted a randomised, prospective, open, cross over trial on 44 patients with acute respiratory failure in the general intensive care unit of a university hospital. After a stabilization period of 8 h, a cross over trial of 2 × 2 h was conducted. Apart from the PRVC/VC mode, ventilator settings were comparable. The following parameters were recorded for each patient: days on ventilator, failure in the assigned mode of ventilation (peak inspiratory pressure  > 50 cmH2O) and survival.
        
        
          Results:
          In the crossover trial, peak inspiratory pressure was significantly lower using PRVC than with VC (20 cmH2O vs 24 cmH2O, P < 0.0001). No other statistically significant differences were found.
        
        
          Conclusions:
          Peak inspiratory pressure was significantly lower during PRVC ventilation than during VC ventilation, and thus PRVC may be superior to VC in certain patients. However, in this small group of patients, we could not demonstrate that PRVC improved outcome.

Tags: acute-respiratory-failure, mechanical-ventilation, nih, pressure-regulated-ventilation, volume-control-ventilation
Organization: U.S. Department of Health & Human Services
Influence of twenty-five per cent human serum albumin on total and
		  ionized calcium concentrations

Background:
          A inverse correlation has been found between changes in ionized
				calcium concentrations and the addition of albumin in vitro, which may
				explain adverse cardiovascular effects attributed to exogenous albumin in
				vivo. The purpose of this investigation was to determine the interaction
				(if any) between exogenous 25% albumin administration (100 ml given over
				< 30 min) and calcium concentrations in patients, all but one of whom were in
				an intensive care unit.
        
        
          Results:
          There were no significant differences in the ionized calcium
				concentrations obtained before, at the end and 6 h after the administration of
				albumin (1.09 ± 0.23, 1.06 ± 0.22, 1.06 ± 0.21 mmol/l,
				respectively). Similarly, there were no significant differences in the total
				calcium concentrations between these same time periods (2.03 ± 0.18,
				2.05 ± 0.20, 2.08 ± 0.23 mmol/l, respectively).
        
        
          Conclusions:
          In patients receiving infusions of 25% albumin, it appears that
				circulating calcium concentrations are well regulated by homeostatic
				mechanisms. Albumin infusions had no effect on calcium concentrations, although
				it is possible that temporary changes of questionable clinical importance may
				have occurred between measurement periods.

Tags: calcium-levels, intensive-care, ionized-calcium, nih, serum-albumin
Organization: U.S. Department of Health & Human Services
Decreased levels of dehydroepiandrosterone sulphate in severe critical illness: a sign of exhausted adrenal reserve?

Introduction
          Dehydroepiandrosterone (DHEA) and its sulphate (DHEAS) are pleiotropic adrenal hormones with immunostimulating and antiglucocorticoid effects. The present study was conducted to evaluate the time course of DHEAS levels in critically ill patients and to study their association with the hypothalamic–pituitary–adrenal axis.
        
        
          Materials and method
          This was a prospective observational clinical and laboratory study, including 30 patients with septic shock, eight patients with multiple trauma, and 40 age- and sex-matched control patients. We took serial measurements of blood concentrations of DHEAS, cortisol, tumour necrosis factor-α and IL-6, and of adrenocorticotrophic hormone immunoreactivity over 14 days or until discharge/death.
        
        
          Results
          On admission, DHEAS was extremely low in septic shock (1.2 ± 0.8 mol/l) in comparison with multiple trauma patients (2.4 ± 0.5 μmol/l; P < 0.05) and control patients (4.2 ± 1.8; P < 0.01). DHEAS had a significant (P < 0.01) negative correlation with age, IL-6 and Acute Physiology and Chronic Health Evaluation II scores in both patient groups. Only during the acute phase did DHEAS negatively correlate with dopamine. Nonsurvivors of septic shock (n = 11) had lower DHEAS levels (0.4 ± 0.3 μmol/l) than did survivors (1.7 ± 1.1 μmol/l; P < 0.01). The time course of DHEAS exhibited a persistent depletion during follow up, whereas cortisol levels were increased at all time points.
        
        
          Conclusion
          We identified extremely low DHEAS levels in septic shock and, to a lesser degree, in multiple trauma patients as compared with those of age- and sex-matched control patients. There appeared to be a dissociation between DHEAS (decreased) and cortisol (increased) levels, which changed only slightly over time. Nonsurvivors of sepsis and patients with relative adrenal insufficiency had the lowest DHEAS values, suggesting that DHEAS might be a prognostic marker and a sign of exhausted adrenal reserve in critical illness.

Tags: adrenal-insufficiency, dheas-levels, multiple-trauma, nih, septic-shock
Organization: U.S. Department of Health & Human Services
2016 Uniform Reporting System (URS) Table for Nebraska

This is the 2016 Uniform Reporting System (URS) Output Tables for Nebraska. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-program, mental-health-services, national-outcome-measures, nebraska, samhsa
Organization: U.S. Department of Health & Human Services
2014 CMHS Uniform Reporting System (URS) Table for California

2014 Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for California. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: california-mental-health, mental-health-services, noms-measures, samhsa, urs-data
Organization: U.S. Department of Health & Human Services
2019 Uniform Reporting System (URS) Table for Maine

These are the 2019 Uniform Reporting System (URS) Output Tables for Maine. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant, maine, mental-health-services, noms, samhsa
Organization: U.S. Department of Health & Human Services
Alaska (AK)

This report presents estimates for measures of substance use and mental health based on the combined 2010 and 2011 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for Alaska for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: alaska-survey, mental-health, samhsa, substance-use, suicidal-ideation
Organization: U.S. Department of Health & Human Services
The clinical and molecular spectrum of galactosemia in patients from the Cape Town region of South Africa

Background
          The objective of this study was to document the clinical, laboratory and genetic features of galactosemia in patients from the Cape Town metropolitan region.
        
        
          Methods
          Diagnoses were based on thin layer chromatography for galactosuria/galactosemia and assays of erythrocyte galactose-1-phosphate uridyltransferase (GALT) and galactokinase activities. Patients were screened for the common S135L and Q188R transferase gene mutations, using PCR-based assays. Screening for the S135L mutation in black newborns was used to estimate the carrier rate for galactosemia in black South Africans.
        
        
          Results
          A positive diagnosis of galactosemia was made in 17 patients between the years 1980 to 2001. All had very low or absent galactose-1-phosphate uridyltransferase (GALT) activity, and normal galactokinase levels. The mean age at diagnosis was 5.1 months (range 4 days to 6.5 months). A review of 9 patients showed that hepatomegaly (9/9), and splenomegaly, failure to thrive, developmental delay, bilateral cataracts (6/9) were the most frequent features at diagnosis. Six had conjugated hyperbilirubinemia. Four experienced invasive E. coli infection before diagnosis. Ten patients were submitted to DNA analysis. All 4 black patients and 2 of mixed extraction were homozygous for the S135L allele, while all 3 white patients were homozygous for the Q188R allele. The remaining patient of mixed extraction was heterozygous for the Q188R allele. The estimated carrier frequency of the S135L mutation in 725 healthy black newborns was 1/60.
        
        
          Conclusions
          In the absence of newborn screening the delay in diagnosis is most often unacceptably long. Also, carrier frequency data predict a galactosemia incidence of approximately 1/14 400 for black newborns in the Cape Metropole, which is much higher than the current detection rate. It is thus likely that many patients go undetected.

Tags: galactosemia, galt-deficiency, newborn-screening, nih, south-africa
Organization: U.S. Department of Health & Human Services
2010 CMHS Uniform Reporting System (URS) Output Tables for Rhode Island

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2010. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant, mental-health-services, noms-measures, rhode-island, samhsa
Organization: U.S. Department of Health & Human Services
Expression of interleukin-18 receptor in fibroblast-like synoviocytes

An excess of the proinflammatory substance IL-18 is present in joints of patients with rheumatoid arthritis (RA), and expression of IL-18 receptor (IL-18R) regulates IL-18 bioactivity in various cell types. We examined the expression of IL-18R α-chain and β-chain and the biologic effects of IL-18 in fibroblast-like synoviocytes (FLS) after long-term culture. The presence of both IL-18R chains was a prerequisite for IL-18 signal transduction in FLS. However, all FLS cultures studied were either resistant or barely responsive to IL-18 stimulation as regards cell proliferation, expression of adhesion molecules ICAM-1 and vascular cell adhesion molecule (VCAM)-1, and the release of interstitial collagenase and stromelysin, IL-6 and IL-8, prostaglandin E2, or nitric oxide. We conclude that the presence of macrophages or IL-18R+ T cells that can respond directly to IL-18 is essential for the proinflammatory effects of IL-18 in synovitis in RA.

Tags: fibroblast-synoviocytes, il-18-receptor, nih, rheumatoid-arthritis, synovial-inflammation
Organization: U.S. Department of Health & Human Services
Compound 525251: N''-(4-methyl-phenyl)-N,N,N',N'-tetramethyl-guanidine

Chemical compound data from PubChem database. IUPAC Name: 1,1,3,3-tetramethyl-2-(4-methylphenyl)guanidine. Molecular Formula: C12H19N3. Molecular Weight: 205.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 525581: N,N-Dimethyl-N'-(3-methylphenyl)-p-methylbenzamidine

Chemical compound data from PubChem database. IUPAC Name: N,N,4-trimethyl-N'-(3-methylphenyl)benzenecarboximidamide. Molecular Formula: C17H20N2. Molecular Weight: 252.35. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Patient attitudes toward using computers to improve health services delivery

Background
          The aim of this study was to examine the acceptability of point of care computerized prompts to improve health services delivery among a sample of primary care patients.
        
        
          Methods
          Primary data collection. Cross-sectional survey. Patients were surveyed after their visit with a primary care provider. Data were obtained from patients of ten community-based primary care practices in the spring of 2001.
        
        
          Results
          Almost all patients reported that they would support using a computer before each visit to prompt their doctor to: "do health screening tests" (92%), "counsel about health behaviors (like diet and exercise)" (92%) and "change treatments for health conditions" (86%). In multivariate testing, the only variable that was associated with acceptability of the point of care computerized prompts was patient's confidence in their ability to answer questions about their health using a computer (beta = 0.39, p = .001). Concerns about data security were expressed by 36.3% of subjects, but were not related to acceptability of the prompts.
        
        
          Conclusions
          Support for using computers to generate point of care prompts to improve quality-oriented processes of care was high in our sample, but may be contingent on patients feeling familiar with their personal medical history.

Tags: computerized-prompts, health-services, nih, patient-attitudes, primary-care
Organization: U.S. Department of Health & Human Services
Kansas Intensive Permanency Project (KIPP) Brochure

This brochure provides an overview of the  Kansas Intensive Permanency Project (KIPP), its connection to the Permanency Innovations Initiative (PII), and the intervention used by KIPP, the Parent Management Training - Oregon Model (PMTO™).

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: child, data, intervention, policy, scope
Organization: U.S. Department of Health & Human Services