AndreaBozzo/ceres-open-data-index huggingface dataset:
Links between complement deficiency and apoptosis

Deficiency in the classical pathway complement components displays a hierarchical association with the development of systemic lupus erythematosus (SLE). In addition, SLE causes consumption of complement. C1q- and C4-deficient mice develop a lupus-like disease and exhibit impaired clearance of apoptotic cells. The autoantigens targeted in SLE have been localised to the surface of apoptotic cells, which may be the source of these antigens. Although apoptosis was originally thought to be an immunologically inert process, dendritic cells can present epitopes derived from apoptotic cells, and immunization with apoptotic cells leads to the generation of autoantibodies. These findings taken together indicate that a defect in complement-dependent clearance of apoptotic cells may increase susceptibility to the development of autoimmunity.

Tags: apoptosis-clearance, autoimmunity, complement-deficiency, nih, systemic-lupus-erythematosus
Organization: U.S. Department of Health & Human Services
Compound 525124: Methylpropenylbenzene

Chemical compound data from PubChem database. IUPAC Name: 1-methyl-2-prop-1-enylbenzene. Molecular Formula: C10H12. Molecular Weight: 132.2. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Clinical applicability of molecular biology: the case of the long QT syndrome

The clinical applicability of molecular cardiology has been questioned at length and by many clinical investigators. The congenital long QT syndrome (LQTS) provides an excellent example of how tight the relationship can be between molecular biology and clinical cardiology. The advent of molecular diagnosis has demonstrated how low the penetrance can be in LQTS; this implies that there are many gene carriers who do not show the clinical phenotype and may have a normal QT interval despite being at risk. There is also a gene-specific predisposition to be at risk for cardiac arrest under different circumstances, and this provides additional basis for a gene-specific approach to therapy.

Tags: genetic-arrhythmias, long-qt-syndrome, molecular-cardiology, nih, sudden-cardiac-death
Organization: U.S. Department of Health & Human Services
Evrim Bougie: A new instrument in the management of urethral strictures

Background
          In this study a new instrument and technique is described for the endoscopic treatment of complete posterior urethral strictures, which may result in serious complications and sometimes require troublesome treatments.
        
        
          Methods
          Three patients with complete posterior urethral obstruction were treated endoscopically with the guidance of a new instrument: Evrim Bougie. Evrim Bougie looks like a Guyon Bougie, has a curved end, which facilitates getting into the bladder through the cystostomy tract and with a built in channel of 1.5 mm in diameter for a sliding needle exiting at its tip. Having confirmed fluoroscopically and endoscopically that the sliding needle had passed across the strictured segment, the strictured segment was incised with internal urethrotomy, distal to the strictured segment, and urethral continuity was accomplished. At the end of the operation a Foley urethral catheter was easily placed into the bladder per urethra. Patients were instructed in self-catheterization after removal of the urethral catheter. All patients achieved normal voiding at postoperative 7th month follow-up evaluation.
        
        
          Conclusion
          Internal urethrotomy could be performed under the guidance of the sliding needle of Evrim Bougie advanced from above the posterior urethral strictures, which to our knowledge was described for the first time in the English literature. We also believe that there may be other possible indications of Evrim Bougie for different procedures in urethral surgery.

Tags: endoscopic-treatment, evrim-bougie, nih, urethral-stricture, urethrotomy
Organization: U.S. Department of Health & Human Services
Federal Parent Locator Service for Child Welfare Staff and Defining Automated Functions in Comprehensive Child Welfare Information Systems Presentation

This joint Office of Child Support Enforcement (OCSE) and DSS presentation describes the use of the Federal Parent Locator Service (FPLS) in child welfare cases, and provides guidance on defining and reporting Automated Functions, as defined by Federal Regulations 45 CFR 1355.53, as part of Comprehensive Child Welfare Information System (CCWIS) Advance Planning Document (APD) submissions, as defined by Federal Regulations 45 CFR 1355.52(i) and Federal Regulations 45 CFR 95.611.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: guidance, instruction, policy, regulation, reporting
Organization: U.S. Department of Health & Human Services
Compound 530410: 15-Methyltritriacontane

Chemical compound data from PubChem database. IUPAC Name: 15-methyltritriacontane. Molecular Formula: C34H70. Molecular Weight: 478.9. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Hisactophilin is involved in osmoprotection in Dictyostelium

Background
          Dictyostelium cells exhibit an unusual stress response as they protect themselves against hyperosmotic stress. Cytoskeletal proteins are recruited from the cytosolic pool to the cell cortex, thereby reinforcing it. In order to gain more insight into the osmoprotective mechanisms of this amoeba, we used 1-D and 2-D gel electrophoresis to identify new proteins that are translocated during osmotic shock.
        
        
          Results
          We identified hisactophilin as one of the proteins that are enriched in the cytoskeletal fraction during osmotic shock. In mutants lacking hisactophilin, viability is reduced under hyperosmotic stress conditions. In wild type cells, serine phosphorylation of hisactophilin was specifically induced by hypertonicity, but not when other stress conditions were imposed on cells. The phosphorylation kinetics reveals a slow accumulation of phosphorylated hisactophilin from 20–60 min after onset of the hyperosmotic shock condition.
        
        
          Conclusion
          In the present study, we identified hisactophilin as an essential protein for the osmoprotection of Dictyostelium cells. The observed phosphorylation kinetics suggest that hisactophilin regulation is involved in long-term osmoprotection and that phosphorylation occurs in parallel with inactivation of the dynamic actin cytoskeleton.

Tags: cell-viability, dictyostelium, hisactophilin, nih, osmotic-stress
Organization: U.S. Department of Health & Human Services
Compound 527272: m-Mentha-1(7),8-diene

Chemical compound data from PubChem database. IUPAC Name: 1-methylidene-3-prop-1-en-2-ylcyclohexane. Molecular Formula: C10H16. Molecular Weight: 136.23. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Youths Living with a Veteran Father Are More Likely to Use Illicit Drugs, Tobacco, or Alcohol (2002 to 2010 NSDUH)

This report uses 2002 to 2010 National Survey on Drug Use and Health (NSDUH) to assess past month alcohol, cigarette, illicit drug use among youth aged 12 to 17 living with a veteran father and youth living with a nonveteran father.

Tags: adolescent-health, nsduh-data, samhsa, veteran-families, youth-substance-use
Organization: U.S. Department of Health & Human Services
Gene therapy moves forward - The Second International Meeting on Gene and Cell Therapies of Arthritis and Related Disorders, 17-18 May 2001, Montpellier, France

The field of gene therapy for bone and joint disorders has grown considerably over the last two and a half years. Investigators have shown that ex vivo or in vivo gene transfer is highly effective in blocking arthritis or facilitating repair of damaged cartilage or bone. The feasibility of applying gene therapy for the treatment of arthritis in humans has also been demonstrated. Thus, gene therapy appears poised to make significant contributions to the clinical treatment of joint and bone diseases in the near future.

Tags: arthritis-treatment, bone-disorders, cell-therapy, gene-therapy, nih
Organization: U.S. Department of Health & Human Services
Medical errors: how the US Government is addressing the problem

November's Institute of Medicine (IOM) report on medical errors has sparked debate among US health policy makers as to the appropriate response to the problem. Proposals range from the implementation of nationwide mandatory reporting with public release of performance data to voluntary reporting and quality-assurance efforts that protect the confidentiality of error-related data. Any successful safety program will require a national effort to make significant investments in information technology infrastructure, and to provide an environment and education that enables providers to contribute to an active quality-improvement process.

Tags: mandatory-reporting, medical-errors, nih, patient-safety, quality-improvement
Organization: U.S. Department of Health & Human Services
A cross-sectional study of early identification of postpartum depression: Implications for primary care providers from The Ontario Mother & Infant Survey

Background
          This survey's objective was to provide planning information by examining utilization patterns, health outcomes and costs associated with existing practices in the management of postpartum women and their infants. In particular, this paper looks at a subgroup of women who score ≥ 12 on the Edinburgh Postnatal Depression Survey (EPDS).
        
        
          Methods
          The design is cross-sectional with follow-up at four weeks after postpartum hospital discharge. Five Ontario hospitals, chosen for their varied size, practice characteristics, and geographic location, provided the setting for the study. The subjects were 875 women who had uncomplicated vaginal deliveries of live singleton infants. The main outcome measures were the EPDS, the Duke UNC Functional Social Support Questionnaire and the Health and Social Services Utilization Questionnaire.
        
        
          Results
          EPDS scores of ≥ 12 were found in 4.3 to 15.2% of otherwise healthy women. None of these women were being treated for postpartum depression. Best predictors of an EPDS score of ≥ 12 were lack: of confident support, lack of affective support, household income of <$20,000, wanting to stay in hospital longer, identification of learning needs while in hospital, self-identified care needs for an emotional/mental health problem that have not been met and mother's rating of own and baby's health as fair or poor.
        
        
          Conclusions
          Primary care physicians, midwives, and public health nurses need to screen for depression at every opportunity early in the postpartum period. A mother's expression of undue concern about her own or her baby's health may be predictive of postpartum depression. Flexible, mother-focused support from community providers may decrease the prevalence of postpartum depression.

Tags: cross-sectional-study, edinburgh-postnatal-depression-scale, maternal-health, nih, postpartum-depression
Organization: U.S. Department of Health & Human Services
Effect of Contour Shape of Nervous System Electromagnetic Stimulation Coils on the Induced Electrical Field Distribution

Background
          Electromagnetic stimulation of the nervous system has the advantage of reduced discomfort in activating nerves. For brain structures stimulation, it has become a clinically accepted modality. Coil designs usually consider factors such as optimization of induced power, focussing, field shape etc. In this study we are attempting to find the effect of the coil contour shape on the electrical field distribution for magnetic stimulation.
        
        
          Method and results
          We use the maximum of the induced electric field stimulation in the region of interest as the optimization criterion. This choice required the application of the calculus of variation, with the contour perimeter taken as a pre-set condition. Four types of coils are studied and compared: circular, square, triangular and an 'optimally' shaped contour. The latter yields higher values of the induced electrical field in depths up to about 30 mm, but for depths around 100 mm, the circular shape has a slight advantage. The validity of the model results was checked by experimental measurements in a tank with saline solution, where differences of about 12% were found. In view the accuracy limitations of the computational and measurement methods used, such differences are considered acceptable.
        
        
          Conclusion
          We applied an optimization approach, using the calculus of variation, which allows to obtain a coil contour shape corresponding to a selected criterion. In this case, the optimal contour showed higher intensities for a longer line along the depth-axis. The method allows modifying the induced field structure and focussing the field to a selected zone or line.

Tags: coil-design, electrical-field, electromagnetic-stimulation, nervous-system, nih
Organization: U.S. Department of Health & Human Services
Spouses and Children of U.S. Military Personnel: Results from the 2015 National Survey on Drug Use and Health

This report presents findings from the 2015 National Survey on Drug Use and Health (NSDUH) with a focus on comparing estimates related to substance use and mental health for military family members (spouses and children) with general population estimates.  The numbers of military family members included in the 2015 NSDUH were relatively small.  As a consequence, the report focuses on wives aged 18 to 49 and children aged 12 to 17.  In the general area of substance use, the report includes estimates for past year use of any illicit substances (marijuana, cocaine in any form including crack, heroin, hallucinogens, inhalants, and methamphetamine and misuse of four categories of prescription drugs -- pain relievers, tranquilizers, stimulants and sedatives), past year cigarette use, past year alcohol use (both any use and binge use), and past year treatment for substance use, including alcohol use.  In the general area of mental health, the report includes estimates for any mental illness (AMI) in the past year for wives.  For both wives and children, the report includes estimates for past year major depressive episode (MDE) and mental health service use.  For children, estimates of mental health service are reported by general treatment setting (e.g., mental health, educational, medical).  As additional years of data become available, it will be possible in future reports to include both male and female spouses and to make more detailed comparisons -- for example for more specific types of illicit substances used and for treatment received by setting, by race/ethnicity and for spouses, by employment and educational background.

Tags: mental-health, military-families, nsduh-data, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
2010 CMHS Uniform Reporting System (URS) Output Tables for California

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2010. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-program, community-mental-health, mental-health-services, outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Genomic analysis of membrane protein families: abundance and conserved motifs

A genome-wide analysis was carried out on patterns of the classified polytopic membrane protein families, and the distribution of conserved amino acids and motifs in the transmembrane helix regions in these families was also analyzed.

Tags: conserved-motifs, genomic-analysis, membrane-proteins, nih, transmembrane-helix
Organization: U.S. Department of Health & Human Services
Tribal Federal Medical Assistance Percentage Reference Table for FY 2020

This report provides the Federal Medical Assistance Percentages (FMAPs) for fiscal year 2020 as well as relevant per capita income data for tribes expressing interest in operating title IV-E programs.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: affair, data, fiscal, policy, year
Organization: U.S. Department of Health & Human Services
Advanced analysis of a

Background
          Previously, we reported effects of the cryb mutation on circadian rhythms in period and timeless gene expression within isolated peripheral Drosophila tissues. We relied on luciferase activity driven by the respective regulatory genomic elements to provide real-time reporting of cycling gene expression. Subsequently, we developed a tool kit for the analysis of behavioral and molecular cycles. Here, we use these tools to analyze our earlier results as well as additional data obtained using the same experimental designs.
        
        
          Results
          Isolated antennal pairs, heads, bodies, wings and forelegs were evaluated under light-dark cycles. In these conditions, the cryb mutation significantly decreases the number of rhythmic specimens in each case except the wing. Moreover, among those specimens with detectable rhythmicity, mutant rhythms are significantly weaker than cry+ controls. In addition, cryb alters the phase of period gene expression in these tissues. Furthermore, peak phase of luciferase-reported period and timeless expression within cry+ samples is indistinguishable in some tissues, yet significantly different in others. We also analyze rhythms produced by antennal pairs in constant conditions.
        
        
          Conclusions
          These analyses further show that circadian clock mechanisms in Drosophila may vary in a tissue-specific manner, including how the cry gene regulates circadian gene expression.

Tags: circadian-rhythms, cry-mutation, drosophila-melanogaster, gene-expression, nih
Organization: U.S. Department of Health & Human Services
2015 CMHS Uniform Reporting System (URS) Table for Kansas

2015 Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for Kansas. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, national-outcome-measures, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
2016 Uniform Reporting System (URS) Table for South Carolina

This is the 2016 Uniform Reporting System (URS) Output Tables for South Carolina. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant, mental-health-services, outcome-measures, samhsa, south-carolina
Organization: U.S. Department of Health & Human Services
Asthma and PM

PM10 (the mass of particles present in the air having a 50% cutoff for particles with an aerodynamic diameter of 10 μm) is the standard measure of particulate air pollution used worldwide. Epidemiological studies suggest that asthma symptoms can be worsened by increases in the levels of PM10. Epidemiological evidence at present indicates that PM10 increases do not raise the chances of initial sensitisation and induction of disease, although further research is warranted. PM10 is a complex mixture of particle types and has many components and there is no general agreement regarding which component(s) could lead to exacerbations of asthma. However pro-inflammatory effects of transition metals, hydrocarbons, ultrafine particles and endotoxin, all present to varying degrees in PM10, could be important. An understanding of the role of the different components of PM10 in exacerbating asthma is essential before proper risk assessment can be undertaken leading to advice on risk management for the many asthmatics who are exposed to air pollution particles.

Tags: air-quality, asthma-exacerbation, nih, pm10-exposure, respiratory-health
Organization: U.S. Department of Health & Human Services
Compound 525467: 4,5-Dimethyl-3-thiahexane

Chemical compound data from PubChem database. IUPAC Name: 2-ethylsulfanyl-3-methylbutane. Molecular Formula: C7H16S. Molecular Weight: 132.27. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
South Dakota (SD)

This report presents estimates for measures of substance use and mental health based on the combined 2010 and 2011 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for South Dakota for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: mental-health, nsduh, samhsa, south-dakota, substance-use
Organization: U.S. Department of Health & Human Services