AndreaBozzo/ceres-open-data-index huggingface dataset:
Prior Relationship of Adoptive Parent(s) to Child 10/1/1999 - 9/30/2000

This report provides state-specific data from fiscal year 2000 about the prior relationships of the adoptive parents to the children who were adopted through public agencies.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: adoption, data, fiscal, policy, reporting
Organization: U.S. Department of Health & Human Services
Control of dinucleoside polyphosphates by the

Background
          The FHIT gene is lost early in the development of many tumors. Fhit possesses intrinsic ApppA hydrolase activity though ApppA cleavage is not required for tumor suppression. Because a mutant form of Fhit that is functional in tumor suppression and defective in catalysis binds ApppA well, it was hypothesized that Fhit-substrate complexes are the active, signaling form of Fhit. Which substrates are most important for Fhit signaling remain unknown.
        
        
          Results
          Here we demonstrate that dinucleoside polyphosphate levels increase 500-fold to hundreds of micromolar in strains devoid of the Saccharomyces cerevisiae homolog of Fhit, Hnt2. Accumulation of dinucleoside polyphosphates is reversed by re-expression of Hnt2 and is active site-dependent. Dinucleoside polyphosphate levels depend on an intact adenine biosynthetic pathway and time in liquid culture, and are induced by heat shock to greater than 0.1 millimolar even in Hnt2+ cells.
        
        
          Conclusions
          The data indicate that Hnt2 hydrolyzes both ApppN and AppppN in vivo and that, in heat-shocked, adenine prototrophic yeast strains, dinucleoside polyphosphates accumulate to levels in which they may saturate Hnt2.

Tags: apppa-hydrolase, dinucleoside-polyphosphates, fhit-gene, nih, tumor-suppression
Organization: U.S. Department of Health & Human Services
2011 CMHS Uniform Reporting System (URS) Output Tables for New Mexico

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2011. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: mental-health-services, national-outcome-measures, new-mexico, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Kentucky, 2015

This is a behavioral health report for the state of Kentucky. The report utilizes data from the National Survey on Drug Use and Health (NSDUH), and the Uniform Reporting System. The topics addressed in the report include youth substance use, youth mental health and treatment, mental health and treatment, substance use and substance use treatment.

Tags: kentucky-behavioral-health, mental-health-treatment, samhsa, substance-use-kentucky, youth-mental-health
Organization: U.S. Department of Health & Human Services
Long-term reductions in tinnitus severity

Background
          This study was undertaken to assess long-term changes in tinnitus severity exhibited by patients who completed a comprehensive tinnitus management program; to identify factors that contributed to changes in tinnitus severity within this population; to contribute to the development and refinement of effective assessment and management procedures for tinnitus.
        
        
          Methods
          Detailed questionnaires were mailed to 300 consecutive patients prior to their initial appointment at the Oregon Health & Science University Tinnitus Clinic. All patients were then evaluated and treated within a comprehensive tinnitus management program. Follow-up questionnaires were mailed to the same 300 patients 6 to 36 months after their initial tinnitus clinic appointment.
        
        
          Results
          One hundred ninety patients (133 males, 57 females; mean age 57 years) returned follow-up questionnaires 6 to 36 months (mean = 22 months) after their initial tinnitus clinic appointment. This group of patients exhibited significant long-term reductions in self-rated tinnitus loudness, Tinnitus Severity Index scores, tinnitus-related anxiety and prevalence of current depression. Patients who improved their sleep patterns or Beck Depression Inventory scores exhibited greater reductions of tinnitus severity scores than patients who continued to experience insomnia and depression at follow-up.
        
        
          Conclusions
          Individualized tinnitus management programs that were designed for each patient contributed to overall reductions in tinnitus severity exhibited on follow-up questionnaires. Identification and treatment of patients experiencing anxiety, insomnia or depression are vital components of an effective tinnitus management program. Utilization of acoustic therapy also contributed to improvements exhibited by these patients.

Tags: hearing-disorders, longitudinal-study, nih, tinnitus-management, tinnitus-severity
Organization: U.S. Department of Health & Human Services
State Child Abuse and Neglect (SCAN) Policies Database 2019-2023

The SCAN Policies Database includes state definitions and policies from the 50 states, the District of Columbia, and the Commonwealth of Puerto Rico. The SCAN Policies Database 2019 represents data, collected, reviewed, and verified between May 2019 and July 2020, and the data reflect the state definitions and policies for the calendar year 2019. The SCAN Policies Database 2021 represents data collected, reviewed, and verified between July 2021 and January 2022, and the data reflect the state definitions and policies for the calendar year 2021. The SCAN Policies Database 2023 represents data, collected, reviewed, and verified between May 2023 and July 2024, and the data reflect the state definitions and policies for the calendar year 2023.

Investigators: Elizabeth C. Weigensberg, PhD - 
Mathematica
Nuzhat Islam, MS - 
Mathematica
Jean Knab, PhD - 
Mathematica
Mary A. Grider, MBA - 
Mathematica
Jeremy Page, MA - 
Mathematica
Sarah Bardin, BA - 
MathematicaAddison Larson, MS - MathematicaMilena Raketic, , M.Ed  -Mathematica

Tags: abuse, care, ndacan, policy, reporting
Organization: U.S. Department of Health & Human Services
Compound 527332: 1-(3-Methylphenyl)-adamantane

Chemical compound data from PubChem database. IUPAC Name: 1-(3-methylphenyl)adamantane. Molecular Formula: C17H22. Molecular Weight: 226.36. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Role of endothelin-1 in lung disease

Endothelin-1 (ET-1) is a 21 amino acid peptide with diverse biological activity that has been implicated in numerous diseases. ET-1 is a potent mitogen regulator of smooth muscle tone, and inflammatory mediator that may play a key role in diseases of the airways, pulmonary circulation, and inflammatory lung diseases, both acute and chronic. This review will focus on the biology of ET-1 and its role in lung disease.

Tags: endothelin-1, lung-disease, nih, pulmonary-hypertension, pulmonary-inflammation
Organization: U.S. Department of Health & Human Services
Compound 528439: 1-Decene, 6-ethyl

Chemical compound data from PubChem database. IUPAC Name: 6-ethyldec-1-ene. Molecular Formula: C12H24. Molecular Weight: 168.32. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Hawaii, 2015

This is a behavioral health report for the state of Hawaii. The report utilizes data from the National Survey on Drug Use and Health (NSDUH), and the Uniform Reporting System. The topics addressed in the report include youth substance use, youth mental health and treatment, mental health and treatment, substance use and substance use treatment.

Tags: hawaii-behavioral-health, mental-health-treatment, samhsa, substance-use-disorders, youth-substance-use
Organization: U.S. Department of Health & Human Services
Compound 528436: 1-Decene, 4,8-dimethyl

Chemical compound data from PubChem database. IUPAC Name: 4,8-dimethyldec-1-ene. Molecular Formula: C12H24. Molecular Weight: 168.32. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Genetic studies of the Roma (Gypsies): a review

Background
          Data provided by the social sciences as well as genetic research suggest that the 8-10 million Roma (Gypsies) who live in Europe today are best described as a conglomerate of genetically isolated founder populations. The relationship between the traditional social structure observed by the Roma, where the Group is the primary unit, and the boundaries, demographic history and biological relatedness of the diverse founder populations appears complex and has not been addressed by population genetic studies.
        
        
          Results
          Recent medical genetic research has identified a number of novel, or previously known but rare conditions, caused by private founder mutations. A summary of the findings, provided in this review, should assist diagnosis and counselling in affected families, and promote future collaborative research. The available incomplete epidemiological data suggest a non-random distribution of disease-causing mutations among Romani groups.
        
        
          Conclusion
          Although far from systematic, the published information indicates that medical genetics has an important role to play in improving the health of this underprivileged and forgotten people of Europe. Reported carrier rates for some Mendelian disorders are in the range of 5 -15%, sufficient to justify newborn screening and early treatment, or community-based education and carrier testing programs for disorders where no therapy is currently available. To be most productive, future studies of the epidemiology of single gene disorders should take social organisation and cultural anthropology into consideration, thus allowing the targeting of public health programs and contributing to the understanding of population structure and demographic history of the Roma.

Tags: european-health, founder-mutations, genetic-disorders, nih, roma-population
Organization: U.S. Department of Health & Human Services
National Survey of Substance Abuse Treatment Services (N-SSATS): 2011 Data on Substance Abuse Treatment Facilities

This report presents results from the 2011 National Survey of Substance Abuse Treatment Services (N-SSATS), an annual census of facilities providing substance abuse treatment. Conducted by the Substance Abuse and Mental Health Services Administration (SAMHSA), the N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 states, the District of Columbia, and other U.S. jurisdictions.

Tags: addiction-services, behavioral-health-services, samhsa, substance-abuse-treatment, treatment-facilities
Organization: U.S. Department of Health & Human Services
Compound 525147: Diethylene glycol, monoallyl ether, acetate

Chemical compound data from PubChem database. IUPAC Name: 2-(2-prop-2-enoxyethoxy)ethyl acetate. Molecular Formula: C9H16O4. Molecular Weight: 188.22. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Tennessee, 2013

This is a behavioral health report for the state of Tennessee. It uses the  National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment Services (NSSATS) to address the topics of youth substance use , youth mental health and treatment, adult mental health and treatment, substance use, substance use treatment for the years 2008 to 2012.

Tags: behavioral-health, mental-health, samhsa, substance-use, tennessee
Organization: U.S. Department of Health & Human Services
No effects on myocardial ischaemia in patients with stable ischaemic heart disease after treatment with ramipril for 6 months

Objective
          To assess the effects of a 6-month angiotensin-converting enzyme (ACE) inhibitor intervention on myocardial ischaemia.
        
        
          Method
          We randomized 389 patients with stable coronary artery disease to double-blind treatment with ramipril 5 mg/day (n = 133), ramipril 1.25 mg/day (n = 133), or placebo (n = 123). Forty-eight-hour ambulatory electrocardiography was performed at baseline, and after 1 and 6 months.
        
        
          Results
          Relevant baseline variables were similar in all groups. Changes over 6 months in duration of ≥ 1 mm ST-segment depression (STD), total ischaemic burden and maximum STD did not differ significantly between the treatment groups. There was no difference in the frequency of adverse events between the groups.
        
        
          Conclusion
          ACE inhibitor treatment has little impact on incidence and severity of myocardial ischaemia in patients with stable ischaemic heart disease.

Tags: ambulatory-ecg, ischemic-heart-disease, myocardial-ischemia, nih, ramipril-treatment
Organization: U.S. Department of Health & Human Services
Emergency Department Visits for Drug-Related Suicide Attempts Have Increased

This spotlight uses data from the Drug Abuse Warning Network (DAWN) to examine emergency department visits related to suicide attempts that involved drugs. There was an overall increase in drug-related suicide attempts from 2005 to 2011 (for patients ages 12 and older).  The report also examines the trends for individual age groups (12-17, 18-29,  30-44, 45-64, and 65 and older).

Tags: dawn-data, drug-related-suicide, emergency-department-visits, samhsa, suicide-attempt-trends
Organization: U.S. Department of Health & Human Services
Improvements to parallel plate flow chambers to reduce reagent and cellular requirements

Background
          The parallel plate flow chamber has become a mainstay for examination of leukocytes under physiologic flow conditions. Several design modifications have occurred over the years, yet a comparison of these different designs has not been performed. In addition, the reagent requirements of many designs prohibit the study of rare leukocyte populations and require large amounts of reagents.
        
        
          Results
          In this study, we evaluate modifications to a newer parallel plate flow chamber design in comparison to the original parallel plate flow chamber described by Lawrence et al. We show that modifications in the chamber size, internal tubing diameters, injection valves, and a recirculation design may dramatically reduce the cellular and reagent requirements without altering measurements.
        
        
          Conclusions
          These modifications are simple and easily implemented so that study of rare leukocyte subsets using scarce or expensive reagents can occur.

Tags: cell-adhesion, flow-chamber, leukocyte-adhesion, nih, parallel-plate-assay
Organization: U.S. Department of Health & Human Services
Compound 525485: 4-Thia-1-hexanethiol

Chemical compound data from PubChem database. IUPAC Name: 3-ethylsulfanylpropane-1-thiol. Molecular Formula: C5H12S2. Molecular Weight: 136.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2017 Uniform Reporting System (URS) Table for New Jersey

This is the 2017 Uniform Reporting System (URS) Output Tables for New Jersey. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-data, evidence-based-practices, mental-health-services, noms-measures, samhsa
Organization: U.S. Department of Health & Human Services
Publications Using SAMHSA Data4.12b Facilities offering services in sign language for the hearing impaired and in languages other than English, by facility operation and primary focus of facility: 2011. Percent

This is a National Survey of Substance Abuse Treatment Services (N-SSATS) data table showing facilities offering services in sign language for the hearing impaired and in languages other than English, by facility operation and primary focus of facility in 2011. N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 States, the District of Columbia, and other U.S. jurisdictions.

Tags: hearing-impaired-services, language-access, n-ssats, samhsa, substance-abuse-treatment
Organization: U.S. Department of Health & Human Services
Compound 525386: 2,5-Dithiaoctane

Chemical compound data from PubChem database. IUPAC Name: 1-(2-methylsulfanylethylsulfanyl)propane. Molecular Formula: C6H14S2. Molecular Weight: 150.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2010 State Profile — North Dakota

This state profile includes data from facilities in North Dakota that reported to N-SSATS for the survey reference date March 31, 2010. Data were collected on the location, characteristics, services offered, and number of clients in treatment at alcohol and drug abuse treatment facilities (both public and private) in North Dakota. In North Dakota, 57 substance abuse treatment facilities were included in the 2010 N-SSATS, reporting that there were 2,124 clients in substance abuse treatment on March 31, 2010. The survey response rate in North Dakota was 95.1%.

Tags: alcohol-abuse, n-ssats, north-dakota, samhsa, substance-abuse-treatment
Organization: U.S. Department of Health & Human Services
The regulation of CD5 expression in murine T cells

Background
          CD5 is a pan-T cell surface marker that is also present on a subset of B cells, B-1a cells.Functional and developmental subsets of T cells express characteristic CD5 levels that vary over roughly a 30-fold range. Previous investigators have cloned a 1.7 Kb fragment containing the CD5 promoter and showed that it can confer similar lymphocyte-specific expression pattern as observed for endogenous CD5 expression.
        
        
          Results
          We further characterize the CD5 promoter and identify minimal and regulatory regions on the CD5 promoter. Using a luciferase reporter system, we show that a 43 bp region on the CD5 promoter regulates CD5 expression in resting mouse thymoma EL4 T cells and that an Ets binding site within the 43 bp region mediates the CD5 expression. In addition, we show that Ets-1, a member of the Ets family of transcription factors, recognizes the Ets binding site in the electrophoretic mobility shift assay (EMSA). This Ets binding site is directly responsible for the increase in reporter activity when co-transfected with increasing amounts of Ets-1 expression plasmid.
          We also identify two additional evolutionarily-conserved regions in the CD5 promoter (CD5X and CD5Y) and demonstrate the respective roles of the each region in the regulation of CD5 transcription.
        
        
          Conclusion
          Our studies define a minimal and regulatory promoter for CD5 and show that the CD5 expression level in T cells is at least partially dependent on the level of Ets-1 protein. Based on the findings in this report, we propose a model of CD5 transcriptional regulation in T cells.

Tags: cd5-expression, ets-transcription-factors, murine-t-cells, nih, t-cell-regulation
Organization: U.S. Department of Health & Human Services
Severe reperfusion lung injury after double lung transplantation

Aim
          To demonstrate the effects of combined inhaled nitric oxide and surfactant replacement as treatment for acute respiratory distress syndrome. This treatment has not previously been documented for reperfusion injury after double lung transplantation.
        
        
          Method
          A 24-year-old female with cystic fibrosis underwent double lung transplantation. During implantation of the second lung a marked increase in pulmonary artery pressure associated with systemic hypotension, hypoxemia and low cardiac output were observed. Notwithstanding the patient received support from cardiovascular drugs and pulmonary vasodilators cardiopulmonary by-pass was necessary. In the intensive care unit the patient received the same drug support, inhaled nitric oxide and two bronchoscopic applications of bovine surfactant.
        
        
          Results
          A rapid improvement in PaO2/FiO2 within 2–3 hours of administration of surfactant was seen. The patient is well at follow-up 1 year post-transplant.
        
        
          Conclusion
          There is a potential role for a combined therapy with inhaled nitric oxide and surfactant replacement in reperfusion injury after lung transplantation.

Tags: cystic-fibrosis, lung-transplantation, nih, nitric-oxide, reperfusion-injury
Organization: U.S. Department of Health & Human Services
Compound 525089: 2-Propenoic acid, 2,3-dichloro-, methyl ester, (Z)-

Chemical compound data from PubChem database. IUPAC Name: methyl 2,3-dichloroprop-2-enoate. Molecular Formula: C4H4Cl2O2. Molecular Weight: 154.98. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Table 12. Alcohol Use and Binge Alcohol Use in the Past Month among Individuals Aged 12 to 20, by State: Percentages, Annual Averages Based on 2013 and 2014 NSDUHs

Table 12. Alcohol Use and Binge Alcohol Use in the Past Month among Individuals Aged 12 to 20, by State: Percentages, Annual Averages Based on 2013 and 2014 NSDUHs

Tags: binge-drinking, nsduh, samhsa, substance-use-survey, youth-alcohol-use
Organization: U.S. Department of Health & Human Services