AndreaBozzo/ceres-open-data-index huggingface dataset:
2010 State Profile — North Carolina

This state profile includes data from facilities in North Carolina that reported to N-SSATS for the survey reference date March 31, 2010. Data were collected on the location, characteristics, services offered, and number of clients in treatment at alcohol and drug abuse treatment facilities (both public and private) in North Carolina. In North Carolina, 400 substance abuse treatment facilities were included in the 2010 N-SSATS, reporting that there were 33,029 clients in substance abuse treatment on March 31, 2010. The survey response rate in North Carolina was 83.8%.

Tags: addiction-services, n-ssats, north-carolina, samhsa, substance-abuse-treatment
Organization: U.S. Department of Health & Human Services
AFCARS Dashboard May 2025 Webinar

On May 13, 2025, the Children's Bureau hosted a webinar introducing the new AFCARS dashboard. The webinar provided an overview of updated elements, demonstrated the dashboard's key capabilities, and offered critical guidance on how to interpret reported statistics.

Audio Description Version

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: child, data, guidance, program, welfare
Organization: U.S. Department of Health & Human Services
Noninvasive positive pressure ventilation as treatment for acute		  respiratory failure in critically ill patients

Our current state of knowledge on noninvasive positive pressure			 ventilation (NPPV) and technical aspects are discussed in the present review.			 In patients with chronic obstructive pulmonary disease, NPPV can be considered			 a valid therapeutic option to prevent endotracheal intubation. Evidence			 suggests that, before eventual endotracheal intubation, NPPV should be			 considered as first-line intervention in the early phases of acute exacerbation			 of chronic obstructive pulmonary disease. Small randomized and non-randomized			 studies on the application of NPPV in patients with acute hypoxaemic			 respiratory failure showed promising results, with reduction in complications			 such as sinusitis and ventilator-associated pneumonia, and in the duration of			 intensive care unit stay. The conventional use of NPPV in hypoxaemic acute			 respiratory failure still remains controversial, however. Large randomized			 studies are still needed before extensive clinical application in this			 condition.

Tags: acute-respiratory-failure, copd-exacerbation, critical-care, nih, noninvasive-ventilation
Organization: U.S. Department of Health & Human Services
Compound 525323: 5-Methyl-2H-pyrazole-3-carboxylic acid, 2-phenylhydrazide

Chemical compound data from PubChem database. IUPAC Name: 5-methyl-N'-phenyl-1H-pyrazole-3-carbohydrazide. Molecular Formula: C11H12N4O. Molecular Weight: 216.24. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Debate: does it matter how you lower blood pressure?

The evidence base for drug treatment of hypertension is strong. Early trials 
using thiazide diuretics suggested a shortfall in prevention of coronary heart 
disease. The superiority of newer drugs has been widely advocated but trial 
evidence does not support an advantage of beta-blockers, angiotensin converting 
enzyme inhibitors, calcium channel blockers or alpha-blockers for this outcome. 
Even meta-analyses have failed to clarify matters. If this issue is to be 
settled, bigger and better trials of longer duration in high-risk patients are 
needed. Meanwhile, the importance of rigorous blood pressure control using 
multiple drugs has been established. This should be the focus of our attention 
rather than agonising over differences in cause-specific outcomes that may not 
be generalisable to all patient populations.

Tags: antihypertensive-drugs, blood-pressure-control, cardiovascular-outcomes, hypertension-treatment, nih
Organization: U.S. Department of Health & Human Services
Aggregation and retention of human urokinase type plasminogen activator in the yeast endoplasmic reticulum

Background
          Secretion of recombinant proteins in yeast can be affected by their improper folding in the endoplasmic reticulum and subsequent elimination of the misfolded molecules via the endoplasmic reticulum associated protein degradation pathway. Recombinant proteins can also be degraded by the vacuolar protease complex. Human urokinase type plasminogen activator (uPA) is poorly secreted by yeast but the mechanisms interfering with its secretion are largely unknown.
        
        
          Results
          We show that in Hansenula polymorpha overexpression worsens uPA secretion and stimulates its intracellular aggregation. The absence of the Golgi modifications in accumulated uPA suggests that aggregation occurs within the endoplasmic reticulum. Deletion analysis has shown that the N-terminal domains were responsible for poor uPA secretion and propensity to aggregate. Mutation abolishing N-glycosylation decreased the efficiency of uPA secretion and increased its aggregation degree. Retention of uPA in the endoplasmic reticulum stimulates its aggregation.
        
        
          Conclusions
          The data obtained demonstrate that defect of uPA secretion in yeast is related to its retention in the endoplasmic reticulum. Accumulation of uPA within the endoplasmic reticulum disturbs its proper folding and leads to formation of high molecular weight aggregates.

Tags: endoplasmic-reticulum, nih, protein-aggregation, recombinant-protein-secretion, urokinase-plasminogen-activator
Organization: U.S. Department of Health & Human Services
2015 CMHS Uniform Reporting System (URS) Table for Minnesota

2015 Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for Minnesota. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, minnesota, outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
International variation in ethics committee requirements: comparisons across five Westernised nations

Background
          Ethics committees typically apply the common principles of autonomy, nonmaleficence, beneficence and justice to research proposals but with variable weighting and interpretation. This paper reports a comparison of ethical requirements in an international cross-cultural study and discusses their implications.
        
        
          Discussion
          The study was run concurrently in New Zealand, UK, Israel, Canada and USA and involved testing hypotheses about believability of testimonies regarding alleged child sexual abuse. Ethics committee requirements to conduct this study ranged from nil in Israel to considerable amendments designed to minimise participant harm in New Zealand. Assessment of minimal risk is a complex and unreliable estimation further compounded by insufficient information on probabilities of particular individuals suffering harm. Estimating potential benefits/ risks ratio and protecting participants' autonomy similarly are not straightforward exercises.
        
        
          Summary
          Safeguarding moral/humane principles should be balanced with promotion of ethical research which does not impede research posing minimal risk to participants. In ensuring that ethical standards are met and research has scientific merit, ethics committees have obligations to participants (to meet their rights and protect them from harm); to society (to ensure good quality research is conducted); and to researchers (to treat their proposals with just consideration and respect). To facilitate meeting all these obligations, the preferable focus should be promotion of ethical research, rather than the prevention of unethical research, which inevitably results in the impediment of researchers from doing their work. How the ethical principles should be applied and balanced requires further consideration.

Tags: child-sexual-abuse, cross-cultural-research, ethics-committee-review, nih, research-ethics
Organization: U.S. Department of Health & Human Services
Emergency Department Visits for Drug-Related Suicide Attempts Involving Antidepressants More Likely to Result in Follow-up Care among Adolescents

This Drug Abuse Warning Network (DAWN) spotlight is about emergency department visits by status of follow-up care for drug-related suicide attempts involving antidepressants among adolescents aged 12 to 17 from 2008 to 2010.

Tags: adolescent-suicide, antidepressant-overdose, ed-visits, follow-up-care, samhsa
Organization: U.S. Department of Health & Human Services
Dr. Elinore F. McCance-Katz, Mental Health and Substance Use Challenges to Our Youth: A Call to Action

California Mental Health Advocates for Children and Youth (CMHACY), Mental Health and Substance Use Challenges to Our Youth: A Call to Action, May 17, 2019, Elinore F. McCance-Katz, MD, PhD, Assistant Secretary for Mental Health and Substance Use, Substance Abuse and Mental Health Services Administration, Department of Health and Human Services.View theslides (PPTX)presented by Dr. Elinore F. McCance-Katz.

Tags: mccance-katz, samhsa, samhsa-presentation, substance-use-youth, youth-mental-health
Organization: U.S. Department of Health & Human Services
MtnK, methylthioribose kinase, is a starvation-induced protein in Bacillus subtilis

Background
          Methylthioadenosine, the main by-product of spermidine synthesis, is degraded in Bacillus subtilis as adenine and methylthioribose. The latter is an excellent sulfur source and the precursor of quorum-sensing signalling molecules. Nothing was known about methylthioribose recycling in this organism.
        
        
          Results
          Using trifluoromethylthioribose as a toxic analog to select for resistant mutants, we demonstrate that methylthioribose is first phosphorylated by MtnK, methylthioribose kinase, the product of gene mtnK (formerly ykrT), expressed as an operon with mtnS (formerly ykrS) in an abundant transcript with a S-box leader sequence. Although participating in methylthioribose recycling, the function of mtnS remained elusive. We also show that MtnK synthesis is boosted under starvation condition, in the following decreasing order: carbon-, sulfur- and nitrogen-starvation. We finally show that this enzyme is part of the family Pfam 01633 (choline kinases) which belongs to a large cluster of orthologs comprizing antibiotic aminoglycoside kinases and protein serine/threonine kinases.
        
        
          Conclusions
          The first step of methylthioribose recycling is phosphoryltaion by MTR kinase, coded by the mtnK (formerly ykrT) gene. Analysis of the neighbourhood of mtnK demonstrates that genes located in its immediate vicinity (now named mtnUVWXYZ, formerly ykrUVWXYZ) are also required for methylthioribose recycling.

Tags: bacillus-subtilis, methylthioribose-recycling, mtnk-kinase, nih, starvation-response
Organization: U.S. Department of Health & Human Services
Bacteremia in hospitalized patients with human immunodeficiency virus: A prospective, cohort study

Background
          Bacterial infections complicate the course of patients with human immunodeficiency virus infection. The purpose of this study was to describe the bacterial pathogens causing blood stream infection, identify the risk factors for the development of blood stream infection and determine the impact of blood stream infection on the outcome of patients infected with human immunodeficiency virus.
        
        
          Methods
          The incidence, etiology, risk factors and outcome of bacterial blood stream infection were prospectively determined in 1,225 consecutive hospitalizations of adults with human immunodeficiency virus infection.
        
        
          Results
          Blood stream infection occurred in 88 hospitalizations (7%); 73 of 89 infections (82%) were community acquired. The most commonly isolated gram-positive organism was Streptococcus pneumoniae (21); gram-negative, Escherichia coli (14). Blood stream infection was detected in 8% of African Americans and 22% of Hispanics compared with 2% of whites (P = 0.0013). Patients with blood stream infection had higher white blood cell counts (median, 6.5 vs. 4.9 × 109/L; P = 0.0002) and mortality (18% vs. 4%; P < 0.0001) than patients without infection.
        
        
          Conclusions
          In patients with human immunodeficiency virus, blood stream infection is associated with an increased mortality rate. Recognition of the incidence, etiology, and risk factors of blood stream infection in patients with human immunodeficiency virus infection could lead to measures that reduce the increased mortality.

Tags: bacteremia, bloodstream-infection, hiv-infections, hospitalized-patients, nih
Organization: U.S. Department of Health & Human Services
2017 Uniform Reporting System (URS) Table for Michigan

This is the 2017 Uniform Reporting System (URS) Output Tables for Michigan. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: mental-health-services, michigan-health-data, national-outcome-measures, samhsa, substance-abuse-treatment
Organization: U.S. Department of Health & Human Services
Idaho (ID)

This report presents Idaho\'s estimates for 25 measures of substance use and mental health based on the combined 2009 and 2010 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for Idaho for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: idaho, mental-health, nsduh, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Compound 528404: 2,4-Diethyloxazole

Chemical compound data from PubChem database. IUPAC Name: 2,4-diethyl-1,3-oxazole. Molecular Formula: C7H11NO. Molecular Weight: 125.17. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Improved analytical methods for microarray-based genome-composition analysis

Genome-composition analysis using microarrays can be used to categorize genes into 'present' and 'divergent' categories. This involves selecting a signal value that is used as a cutoff to discriminate present and divergent genes, but this can result in the misclassification of many genes. A method is described that depends on the shape of the signal-ratio distribution and does not require empirical determination of a cutoff. Many genes previously classified as present using static methods are in fact divergent on the basis of microarray signal; this is corrected by our algorithm.

Tags: gene-expression, genome-composition, genomic-research, microarray-analysis, nih
Organization: U.S. Department of Health & Human Services
Analysis of EF-hand-containing proteins in

Three out of the four classes of Ca2+-binding proteins in plants contain Ca 2+ -binding EF-hand motif(s). A maximum of 250 proteins possibly having EF-hands were identified. Diverse proteins, including enzymes, proteins involved in transcription and translation, protein- and nucleic-acid-binding proteins and a large number of unknown proteins, have one or more putative EF-hands.

Tags: calcium-binding-proteins, ef-hand-proteins, nih, plant-proteins, protein-motif-analysis
Organization: U.S. Department of Health & Human Services
2016 Uniform Reporting System (URS) Table for California

This is the 2016 Uniform Reporting System (URS) Output Tables for California. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: california-mental-health, mental-health-services, outcome-measures, samhsa, urs-data
Organization: U.S. Department of Health & Human Services
Compound 528448: 1-Heptadecene, 3,8,12,16-tetramethyl

Chemical compound data from PubChem database. IUPAC Name: 3,8,12,16-tetramethylheptadec-1-ene. Molecular Formula: C21H42. Molecular Weight: 294.6. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2019 Uniform Reporting System (URS) Table for Rhode Island

These are the 2019 Uniform Reporting System (URS) Output Tables for Rhode Island. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant, mental-health-services, outcome-measures, rhode-island, samhsa
Organization: U.S. Department of Health & Human Services
Identification and preliminary characterization of mouse

Background
          The metalloprotease-disintegrin family, or ADAM, proteins, are implicated in cell-cell interactions, cell fusion, and cell signaling, and are widely distributed among metazoan phyla. Orthologous relationships have been defined for a few ADAM proteins including ADAM10 (Kuzbanian), and ADAM17 (TACE), but evolutionary relationships are not clear for the majority of family members. Human ADAM33 refers to a testis cDNA clone that does not contain a complete open reading frame, but portions of the predicted protein are similar to Xenopus laevis ADAM13.
        
        
          Results
          In a 48 kb region of mouse DNA adjacent to the Attractin gene on mouse chromosome 2, we identified sequences very similar to human ADAM33. A full-length mouse cDNA was identified by a combination of gene prediction programs and RT-PCR, and the probable full-length human cDNA was identified by comparison to human genomic sequence in the homologous region on chromosome 20p13. Mouse ADAM33 is 44% identical to Xenopus laevis ADAM13, however a phylogenetic alignment and consideration of functional domains suggests that the two genes are not orthologous. Mouse Adam33 is widely expressed, most highly in the adult brain, heart, kidney, lung and testis.
        
        
          Conclusions
          While mouse ADAM33 is similar to Xenopus ADAM13 in sequence, further examination of its embryonic expression pattern, catalytic activity and protein interactions will be required to assess the functional relationship between these two proteins. Adam33 is expressed in the mouse adult brain and could play a role in complex processes that require cell-cell communication.

Tags: adam-proteins, metalloprotease-disintegrin, mouse-genetics, nih
Organization: U.S. Department of Health & Human Services
Compound 525658: p-Bromobenzylidene-(3-nitrophenyl)-amine

Chemical compound data from PubChem database. IUPAC Name: 1-(4-bromophenyl)-N-(3-nitrophenyl)methanimine. Molecular Formula: C13H9BrN2O2. Molecular Weight: 305.13. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Incidence Tables (Prevalence Estimates) - 4.1 to 4.16

These detailed tables present totals and prevalence estimates of substance use initiation from the 2010 National Survey on Drug Use and Health (NSDUH). Substances examined include illicit drugs (e.g., marijuana, cocaine, heroin, hallucinogens (including LSD, PCP, Ecstasy), inhalants, and the nonmedical use of prescription-type pain relievers (including OxyContin), tranquilizers, stimulants, sedatives, alcohol, and tobacco products (including cigarettes, smokeless tobacco, and cigars). Results are provided by age group and gender. Estimates are provided for both 2010 and 2009.

Tags: initiation-rates, nsduh-2010, prevalence-estimates, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
2014 CMHS Uniform Reporting System (URS) Table for Virginia

2014 Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for Virginia. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, evidence-based-practices, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Region 9, Volume 5

This is a behavioral health report for HHS Region IX of the United States and utilizes data from the National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment (N-SSATS), collected annually. The topics addressed in the reports include youth substance use, adult mental health and treatment, and substance use treatment.

Tags: behavioral-health, mental-health, region-9, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Illinois 2016 Potential Areas for Addressing Service Gaps for Opioid Treatment

The purpose of the medication-assisted treatment (MAT) facility maps is to identify areas on a state-by-state basis that may be potentially underserved by existing treatment facilities. The maps are created with a methodology that seeks to include the highest potential need areas from individual counties so that county-level stakeholders are also informed. The maps are meant to be used as a tool for policy makers to determine potentially underserved areas—not as a definitive representation of these areas.

Tags: illinois-opioids, medication-assisted-treatment, opioid-treatment, samhsa, service-gap-analysis
Organization: U.S. Department of Health & Human Services