AndreaBozzo/ceres-open-data-index huggingface dataset:
2017 Uniform Reporting System (URS) Table for Alaska

This is the 2017 Uniform Reporting System (URS) Output Tables for Alaska. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: alaska, block-grant, mental-health-services, noms, samhsa
Organization: U.S. Department of Health & Human Services
2020 Uniform Reporting System (URS) Table For Tennessee

This is the 2020 Uniform Reporting System (URS) Output Tables for Tennessee. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: evidence-based-practices, mental-health-services, national-outcome-measures, samhsa, urs-data
Organization: U.S. Department of Health & Human Services
Support Vector Machines for predicting protein structural class

Background
          We apply a new machine learning method, the so-called Support Vector Machine method, to predict the protein structural class. Support Vector Machine method is performed based on the database derived from SCOP, in which protein domains are classified based on known structures and the evolutionary relationships and the principles that govern their 3-D structure.
        
        
          Results
          High rates of both self-consistency and jackknife tests are obtained. The good results indicate that the structural class of a protein is considerably correlated with its amino acid composition.
        
        
          Conclusions
          It is expected that the Support Vector Machine method and the elegant component-coupled method, also named as the covariant discrimination algorithm, if complemented with each other, can provide a powerful computational tool for predicting the structural classes of proteins.

Tags: amino-acid-composition, nih, protein-prediction, protein-structural-class, support-vector-machines
Organization: U.S. Department of Health & Human Services
Arizona (AZ)

This report presents Arizona\'s estimates for 25 measures of substance use and mental health based on the combined 2009 and 2010 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for Arizona for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: arizona-health, mental-health, nsduh-data, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Prevention and diagnosis of venous thromboembolism in critically ill patients: a Canadian survey

Background
          Venous thromboembolism (VTE) confers considerable morbidity and mortality in hospitalized patients, although few studies have focused on the critically ill population. The objective of this study was to understand current approaches to the prevention and diagnosis of deep venous thrombosis (DVT) and pulmonary embolism (PE) among patients in the intensive care unit (ICU).
        
        
          Design
          Mailed self-administered survey of ICU Directors in Canadian university affiliated hospitals.
        
        
          Results
          Of 29 ICU Directors approached, 29 (100%) participated, representing 44 ICUs and 681 ICU beds across Canada. VTE prophylaxis is primarily determined by individual ICU clinicians (20/29, 69.0%) or with a hematology consultation for challenging patients (9/29, 31.0%). Decisions are usually made on a case-by-case basis (18/29, 62.1%) rather than by preprinted orders (5/29, 17.2%), institutional policies (6/29, 20.7%) or formal practice guidelines (2/29, 6.9%). Unfractionated heparin is the predominant VTE prophylactic strategy (29/29, 100.0%) whereas low molecular weight heparin is used less often, primarily for trauma and orthopedic patients. Use of pneumatic compression devices and thromboembolic stockings is variable. Systematic screening for DVT with lower limb ultrasound once or twice weekly was reported by some ICU Directors (7/29, 24.1%) for specific populations. Ultrasound is the most common diagnostic test for DVT; the reference standard of venography is rarely used. Spiral computed tomography chest scans and ventilation–perfusion scans are used more often than pulmonary angiograms for the diagnosis of PE. ICU Directors recommend further studies in the critically ill population to determine the test properties and risk:benefit ratio of VTE investigations, and the most cost-effective methods of prophylaxis in medical–surgical ICU patients.
        
        
          Interpretation
          Unfractionated subcutaneous heparin is the predominant VTE prophylaxis strategy for critically ill patients, although low molecular weight heparin is prescribed for trauma and orthopedic patients. DVT is most often diagnosed by lower limb ultrasound; however, several different tests are used to diagnose PE. Fundamental research in critically ill patients is needed to help make practice evidence-based.

Tags: critical-care, icu-survey, nih, venous-thromboembolism, vte-prophylaxis
Organization: U.S. Department of Health & Human Services
Assessing health-related quality of life in patients with inflammatory bowel disease, in Crete, Greece

Background
          Health Related Quality of Life (HRQoL) is an important outcome measure in Inflammatory Bowel Disease (IBD). The aim of our study was to assess HRQoL in a population of 135 Greek patients with IBD.
        
        
          Methods
          A cohort of 135 patients with IBD, 81 with ulcerative colitis (UC) and 54 with Crohn's disease (CD) were enrolled in our study. Demographic and disease-related data were recorded. HRQoL was assessed by a disease-specific and a generic questionnaire, IBDQ and SF-36, respectively. Disease activity was assessed by Harvey-Bradshaw Index and the Colitis Activity Index for CD and UC patients, respectively.
        
        
          Results
          Among all variables recorded in our study, only disease activity had a significant effect on HRQoL. Patients with active disease scored significantly lower on both IBDQ and SF-36 when compared to those in remission. Only two among the four IBDQ dimensions, bowel and systemic, had significant ability in distinguishing best patients in remission from those with active disease.
        
        
          Conclusions
          IBD has a negative impact on HRQoL. Patients with active disease are more impaired than patients in remission. In our population of patients bowel and systemic dimensions had a predominant value in patients' perception of quality of life. Patients in our study using the same instrument scored higher than previously reported.

Tags: crohns-disease, health-related-quality-life, ibdq-questionnaire, inflammatory-bowel-disease, nih
Organization: U.S. Department of Health & Human Services
Compound 525215: Chloromethyl 6-chloroheptanoate

Chemical compound data from PubChem database. IUPAC Name: chloromethyl 6-chloroheptanoate. Molecular Formula: C8H14Cl2O2. Molecular Weight: 213.1. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Adolescent Mental Health Service Use and Reasons for Using Services in Specialty, Educational, and General Medical Settings

This report uses 2014 National Surveys on Drug Use and Health (NSDUHs) to estimate the of prevalence of mental health service use among adolescents aged 12 to 17, the setting for the services received (i.e., specialty, education, medical), and the reasons these adolescents receive mental health services were analyzed. Estimates are presented by age subgroups among adolescents, gender, race/ethnicity, and rural residence status.

Tags: adolescent-mental-health, mental-health-services, nsduh-data, samhsa, service-utilization
Organization: U.S. Department of Health & Human Services
2016  Uniform Reporting System (URS) Table for Oklahoma

This is the 2016 Uniform Reporting System (URS) Output Tables for Oklahoma. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant, mental-health-services, oklahoma, outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Table 10. 2011-2012 NSDUH Binge Alcohol Use in the Past Month, by Age Group and State

Table 10. Binge Alcohol Use in the Past Month, by Age Group and State: Percentages, Annual Averages Based on 2011 and 2012 NSDUHs. Results are provided by State and for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: alcohol-use, binge-drinking, nsduh, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
Anorexigen-induced pulmonary hypertension and the serotonin (5-HT) hypothesis: lessons for the future in pathogenesis

Epidemiological studies have established that fenfluramine, D-fenfluramine, and aminorex, but not other appetite suppressants, increase the risk of primary pulmonary hypertension (PH). One current hypothesis suggests that fenfluramine-like medications may act through interactions with the serotonin (5-hydroxytryptamine [5-HT]) transporter (5-HTT) located on pulmonary artery smooth muscle cells and responsible for the mitogenic action of 5-HT. Anorexigens may contribute to PH by boosting 5-HT levels in the bloodstream, directly stimulating smooth muscle cell growth, or altering 5-HTT expression. We suggest that individuals with a high basal level of 5-HTT expression related to the presence of the long 5-HTT gene promoter variant may be particularly susceptible to one or more of these potential mechanisms of appetite-suppressant-related PH.

Tags: anorexigen-induced, fenfluramine, nih, pulmonary-hypertension, serotonin-transporter
Organization: U.S. Department of Health & Human Services
Compound 527230: Methyl 2-(8,8a-dimethyl-1,3,4,6,7,8-hexahydronaphthalen-2-ylidene)propanoate

Chemical compound data from PubChem database. IUPAC Name: methyl 2-(8,8a-dimethyl-1,3,4,6,7,8-hexahydronaphthalen-2-ylidene)propanoate. Molecular Formula: C16H24O2. Molecular Weight: 248.36. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
The NSDUH Report: Substance Use among 12th Grade Aged Youths by Dropout Status

This issue of the National Survey on Drug Use and Health (NSDUH) Report presents combined 2002 to 2010 data to examine substance use patterns among

Tags: adolescent-substance-use, high-school-dropouts, nsduh, samhsa, youth-drug-use
Organization: U.S. Department of Health & Human Services
Meta-analysis, Simpson's paradox, and the number needed to treat

Background
          There is debate concerning methods for calculating numbers needed to treat (NNT) from results of systematic reviews.
        
        
          Methods
          We investigate the susceptibility to bias for alternative methods for calculating NNTs through illustrative examples and mathematical theory.
        
        
          Results
          Two competing methods have been recommended: one method involves calculating the NNT from meta-analytical estimates, the other by treating the data as if it all arose from a single trial. The 'treat-as-one-trial' method was found to be susceptible to bias when there were imbalances between groups within one or more trials in the meta-analysis (Simpson's paradox). Calculation of NNTs from meta-analytical estimates is not prone to the same bias. The method of calculating the NNT from a meta-analysis depends on the treatment effect used. When relative measures of treatment effect are used the estimates of NNTs can be tailored to the level of baseline risk.
        
        
          Conclusions
          The treat-as-one-trial method of calculating numbers needed to treat should not be used as it is prone to bias. Analysts should always report the method they use to compute estimates to enable readers to judge whether it is appropriate.

Tags: meta-analysis-bias, nih, number-needed-treat, simpsons-paradox, treatment-effectiveness
Organization: U.S. Department of Health & Human Services
Congenital sucrase-isomaltase deficiency presenting with failure to thrive, hypercalcemia, and nephrocalcinosis

Background
          Disaccharide Intolerance Type I (Mendelian Interance in Man database: *222900) is a rare inborn error of metabolism resulting from mutation in sucrase-isomaltase (Enzyme Catalyzed 3.2.1.48). Usually, infants with SI deficiency come to attention because of chronic diarrhea and nutritional evidence of malabsorption.
        
        
          Case Presentation
          We describe an atypical presentation of this disorder in a 10-month-old infant. In addition to chronic diarrhea, the child displayed severe and chronic hypercalcemia, the evaluation of which was negative. An apparently coincidental right orbital hemangioma was detected. Following identification of the SI deficiency, an appropriately sucrose-restricted, but normal calcium diet regimen was instituted which led to cessation of diarrhea, substantial weight gain, and resolution of hypercalcemia.
        
        
          Conclusions
          This case illustrates that, similar to congenital lactase deficiency (Mendelian Interance in Man database: *223000, Alactasia, Hereditary Disaccharide Intolerance Type II), hypercalcemia may complicate neonatal Sucrase-Isomaltase deficiency. Hypercalcemia in the presence of chronic diarrhea should suggest disaccharide intolerance in young infants.

Tags: disaccharide-intolerance, failure-to-thrive, hypercalcemia, nih, sucrase-isomaltase-deficiency
Organization: U.S. Department of Health & Human Services
2011 CMHS Uniform Reporting System (URS) Output Tables for Texas

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2011. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, national-outcome-measures, samhsa, texas
Organization: U.S. Department of Health & Human Services
Delaware (DE)

This report presents estimates for measures of substance use and mental health based on the combined 2010 and 2011 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for Delaware for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: delaware-health, mental-health, nsduh-data, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
NSDUH 2021 Sample Design Report

This report describes the sample design for the 2021 National Survey on Drug Use and Health (NSDUH). It describes the target population and the five stages of sample selection, including the impact of coronavirus disease 2019 (COVID-19) pandemic. It also includes information on sample weighting and variance estimation procedures for the 2021 NSDUH.Chapter 1 introduces the report, describes the target population, provides a general overview of the 2021 NSDUH sample design, and summarizes the impact of the COVID-19 pandemic on the 2021 NSDUH. Chapter 2 summarizes the 2014 through 2022 coordinated design, while Chapter 3 discusses the first three stages of selection in greater detail. Chapter 4 describes the fourth and fifth stages of selection. Finally, Chapter 5 describes sample weighting and variance estimation procedures for 2021.The document is available as a PDF.

Tags: mental-health, samhsa, sampling-methodology, substance-use, survey-design
Organization: U.S. Department of Health & Human Services
Development of real-time NASBA assays with molecular beacon detection to quantify mRNA coding for HHV-8 lytic and latent genes

Background
          Human herpesvirus-8 (HHV-8) is linked to the pathogenesis of Kaposi's sarcoma (KS), and the HHV-8 DNA load in peripheral blood mononuclear cells (PBMC) is associated with the clinical stage of KS. To examine the expression of HHV-8 in PBMC, four HHV-8 mRNA specific NASBA assays were developed
        
        
          Methods
          We have developed four quantitative nucleic acid sequence-based amplification assays (NASBA-QT) specifically to detect mRNA coding for ORF 73 (latency-associated nuclear antigen, LANA), vGCR (a membrane receptor), vBcl-2 (a viral inhibitor of apoptosis) and vIL-6 (a viral growth factor). The NASBA technique amplifies nucleic acids without thermocycling and mRNA can be amplified in a dsDNA background. A molecular beacon is used during amplification to enable real-time detection of the product. The assays were tested on PBMC samples of two AIDS-KS patients from the Amsterdam Cohort.
        
        
          Results
          For all four assays, the limit of detection (LOD) of 50 molecules and the limit of quantification (LOQ) of 100 molecules were determined using in vitro transcribed RNA. The linear dynamic range was 50 to 107 molecules of HHV-8 mRNA. We found HHV-8 mRNA expression in 9 out of the 10 tested samples.
        
        
          Conclusion
          These real-time NASBA assays with beacon detection provide tools for further study of HHV-8 expression in patient material.

Tags: human-herpesvirus-8, kaposis-sarcoma, mrna-detection, nasba-qt-assays, nih
Organization: U.S. Department of Health & Human Services
Results from the 2011 National Survey on Drug Use and Health: Mental Health Detailed Tables

This is the report pertaining to mental health from the 2011 National Survey on Drug Use and Health (NSDUH). The report presents national estimates of the prevalence of past year mental disorders and past year mental health service utilization for youths aged 12 to 17 and adults aged 18 or older. Among adults, estimates presented include rates and numbers of persons with any mental illness (AMI), serious mental illness (SMI), suicidal thoughts and behavior, major depressive episode (MDE), treatment for depression (among adults with MDE), and mental health service utilization. Estimates for youths include MDE, treatment for depression (among youths with MDE), and mental health service utilization. Measures related to the co-occurrence of mental disorders with substance use or with substance use disorders also are presented for both adults and youths. Results are provided for age group, gender, race/ethnicity, education level, employment status, poverty level, geographic area, insurance status. Comparisons are made between 2011 and 2002 to 2010.

Tags: major-depressive-episode, mental-health, mental-health-services, samhsa, substance-use-disorders
Organization: U.S. Department of Health & Human Services
Long-term experimental evolution in

Background
          Experimental populations of Escherichia coli have evolved for 20,000 generations in a uniform environment. Their rate of improvement, as measured in competitions with the ancestor in that environment, has declined substantially over this period. This deceleration has been interpreted as the bacteria approaching a peak or plateau in a fitness landscape. Alternatively, this deceleration might be caused by non-transitive competitive interactions, in particular such that the measured advantage of later genotypes relative to earlier ones would be greater if they competed directly.
        
        
          Results
          To distinguish these two hypotheses, we performed a large set of competitions using one of the evolved lines. Twenty-one samples obtained at 1,000-generation intervals each competed against five genetically marked clones isolated at 5,000-generation intervals, with three-fold replication. The pattern of relative fitness values for these 315 pairwise competitions was compared with expectations under transitive and non-transitive models, the latter structured to produce the observed deceleration in fitness relative to the ancestor. In general, the relative fitness of later and earlier generations measured by direct competition agrees well with the fitness inferred from separately competing each against the ancestor. These data thus support the transitive model.
        
        
          Conclusion
          Non-transitive competitive interactions were not a major feature of evolution in this population. Instead, the pronounced deceleration in its rate of fitness improvement indicates that the population early on incorporated most of those mutations that provided the greatest gains, and subsequently relied on beneficial mutations that were fewer in number, smaller in effect, or both.

Tags: competitive-interactions, e-coli-evolution, experimental-evolution, microbial-fitness, nih
Organization: U.S. Department of Health & Human Services
Maine (ME)

This report uses 2008 to 2010 National Survey on Drug Use and Health (NSDUH) to assess past year alcohol use disorder and illicit drug use disorder among persons aged 12 or older for Maine overall and for substate regions within Maine. Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE).

Tags: maine, mental-health-indicators, nsduh-data, samhsa, substance-use-disorder
Organization: U.S. Department of Health & Human Services