AndreaBozzo/ceres-open-data-index huggingface dataset:
Assessment of tissue oxygen tension: comparison of dynamic fluorescence quenching and polarographic electrode technique

Introduction and methods
          Dynamic fluorescence quenching is a technique that may overcome some of the limitations associated with measurement of tissue partial oxygen tension (PO2). We compared this technique with a polarographic Eppendorf needle electrode method using a saline tonometer in which the PO2 could be controlled. We also tested the fluorescence quenching system in a rodent model of skeletal muscle ischemiahypoxia.
        
        
          Results
          Both systems measured PO2 accurately in the tonometer, and there was excellent correlation between them (r2 = 0.99). The polarographic system exhibited proportional bias that was not evident with the fluorescence method. In vivo, the fluorescence quenching technique provided a readily recordable signal that varied as expected.
        
        
          Discussion
          Measurement of tissue PO2 using fluorescence quenching is at least as accurate as measurement using the Eppendorf needle electrode in vitro, and may prove useful in vivo for assessment of tissue oxygenation.

Tags: fluorescence-quenching, ischemia-hypoxia, nih, oxygen-tension, tissue-oxygenation
Organization: U.S. Department of Health & Human Services
Mosaic chromosomal aberrations in synovial fibroblasts of patients with rheumatoid arthritis, osteoarthritis, and other inflammatory joint diseases

Chromosomal aberrations were comparatively assessed in nuclei extracted from synovial tissue, primary-culture (P-0) synovial cells, and early-passage synovial fibroblasts (SFB; 98% enrichment; P-1, P-4 [passage 1, passage 4]) from patients with rheumatoid arthritis (RA; n = 21), osteoarthritis (OA; n = 24), and other rheumatic diseases. Peripheral blood lymphocytes (PBL) and skin fibroblasts (FB) (P-1, P-4) from the same patients, as well as SFB from normal joints and patients with joint trauma (JT) (n = 4), were used as controls. Analyses proceeded by standard GTG-banding and interphase centromere fluorescence in situ hybridization. Structural chromosomal aberrations were observed in SFB (P-1 or P-4) from 4 of 21 RA patients (19%), with involvement of chromosome 1 [e.g. del(1)(q12)] in 3 of 4 cases. In 10 of the 21 RA cases (48%), polysomy 7 was observed in P-1 SFB. In addition, aneusomies of chromosomes 4, 6, 8, 9, 12, 18, and Y were present. The percentage of polysomies was increased in P-4. Similar chromosomal aberrations were detected in SFB of OA and spondylarthropathy patients. No aberrations were detected in i) PBL or skin FB from the same patients (except for one OA patient with a karyotype 45,X[10]/46,XX[17] in PBL and variable polysomies in long-term culture skin FB); or ii) synovial tissue and/or P-1 SFB of normal joints or of patients with joint trauma. In conclusion, qualitatively comparable chromosomal aberrations were observed in synovial tissue and early-passage SFB of patients with RA, OA, and other inflammatory joint diseases. Thus, although of possible functional relevance for the pathologic role of SFB in RA, these alterations probably reflect a common response to chronic inflammatory stress in rheumatic diseases.

Tags: chromosomal-aberrations, nih, osteoarthritis, rheumatoid-arthritis, synovial-fibroblasts
Organization: U.S. Department of Health & Human Services
Compound 525181: Heptyl pentyl isophthalate

Chemical compound data from PubChem database. IUPAC Name: 3-O-heptyl 1-O-pentyl benzene-1,3-dicarboxylate. Molecular Formula: C20H30O4. Molecular Weight: 334.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Boston: Drug-Related Emergency Department Visits, 2004-2011 - All Alcohol

Excel file with estimates, rates, relative standard errors, trends and confidence intervals, covering 2004-2011 for emergency department visits involving alcohol in the Boston metropolitan area.  For adults aged 21 and older, the alcohol was found in combination with other drugs. For patients under the age of 21, the visit may involve alcohol alone or in combination with other drugs.File includes data for over 500 drugs, including illicit drugs, prescription and over-the-counter medications, dietary supplements, inhalants and alcohol.  Includes total visits, gender, age group, race/ethnicity, outcome of visit, drug combinations, number of drugs involved in visit, drug frequency, and drugs confirmed by toxicology.Additional detail is provided for illicit drugs, psychotherapeutic drugs, central nervous system (CNS) drugs, respiratory drugs and cardiovascular drugs.

Tags: alcohol-related-ed-visits, boston-emergency-department, drug-combinations, samhsa, substance-abuse-trends
Organization: U.S. Department of Health & Human Services
Miscellaneous Tables  (Prevalence Estimates) - 6.1 to 6.107

These detailed tables present totals and prevalence estimates of the number of days and types of substance use, poly-drug use, nicotine dependence, substance dependence by age of first use, source of substances, social context of substance use, and drunk/drugged driving from the 2011 National Survey on Drug Use and Health (NSDUH). Substances examined include illicit drugs, marijuana, cocaine, heroin, hallucinogens, inhalants, and the nonmedical use of prescription-type pain relievers, tranquilizers, stimulants, and sedatives, and alcohol. Results are provided for lifetime, past year, and past month use by age group, gender, race/ethnicity, education level, employment status, geographic area, pregnancy status, college enrollment status, and probation/parole status. Comparisons are made between 2011 and 2010.

Tags: drug-prevalence, nsduh-survey, poly-drug-use, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Illicit Drug Use Tables (Prevalence Estimates) - 1.1 to 1.92

These detailed tables are population illicit drug use totals and prevalence estimates from the 2012 National Survey on Drug Use and Health (NSDUH). Illicit drugs include marijuana, cocaine, crack, heroin, hallucinogens, inhalants, and the nonmedical use of prescription-type psychotherapeutics, including pain relievers, tranquilizers, stimulants, and sedatives. Results are provided for lifetime, past year, and past month use by age group, gender, race/ethnicity, education level, employment status, and geographic area. Comparisons are made between 2012 and 2011.

Tags: drug-prevalence, illicit-drug-use, nsduh-data, samhsa, substance-use-survey
Organization: U.S. Department of Health & Human Services
San Francisco – SF Div: Drug-Related Emergency Department Visits, 2004-2011 - Adverse Reactions

Excel file with estimates, rates, relative standard errors, trends and confidence intervals, covering 2004-2011 for emergency department visits involving adverse reactions in the San Francisco metropolitan area, San Francisco division. It includes ED visits in which an adverse health consequence (e.g., side effects or an allergic reaction) resulted when taking prescription drugs, over-the-counter medications, or dietary supplements as prescribed or recommended.  This analytic category does not include drug misuse or abuse.File includes data for over 500 drugs, including illicit drugs, prescription and over-the-counter medications, dietary supplements, inhalants and alcohol.  Includes total visits, gender, age group, race/ethnicity, outcome of visit, drug combinations, number of drugs involved in visit, drug frequency, and drugs confirmed by toxicology.Additional detail is provided for illicit drugs, psychotherapeutic drugs, central nervous system (CNS) drugs, respiratory drugs and cardiovascular drugs.

Tags: adverse-drug-events, drug-side-effects, emergency-department-visits, samhsa, san-francisco
Organization: U.S. Department of Health & Human Services
Hypothermia and neurologic outcome in patients following cardiac arrest: should we be hot to cool off our patients?

Hypothermia as a protectant of neurologic function in the treatment of cardiac arrest patients, although not a new concept, is now supported by two recent randomized, prospective clinical trials. The basic science research in support of the effects of hypothermia at the cellular and animal levels is extensive. The process of cooling for cerebral protection holds potential promise for human resuscitation efforts in multiple realms. It appears that, at least, those patients who suffer a witnessed cardiac arrest with ventricular fibrillation and early restoration of spontaneous circulation, such as those who were included in the European and Australian trials (discussed here), should be considered for hypothermic therapy.

Tags: cardiac-arrest, cerebral-protection, neurologic-outcome, nih, therapeutic-hypothermia
Organization: U.S. Department of Health & Human Services
Compound 528421: Dihydrochalcone, 2',4',6',4-tetrahydroxy, tetrakis-TMS

Chemical compound data from PubChem database. IUPAC Name: 1-(4-trimethylsilyloxyphenyl)-3-[2,4,6-tris(trimethylsilyloxy)phenyl]propan-1-one. Molecular Formula: C27H46O5Si4. Molecular Weight: 563.0. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Asymmetric interactions in the adenosine-binding pockets of the MS2 coat protein dimer

Background
          The X-ray structure of the MS2 coat protein-operator RNA complex reveals the existence of quasi-synmetric interactions of adenosines -4 and -10 in pockets formed on different subunits of the coat protein dimer. Both pockets utilize the same five amino acid residues, namely Val29, Thr45, Ser47, Thr59, and Lys61. We call these sites the adenosine-binding pockets.
        
        
          Results
          We present here a heterodimer complementation analysis of the contributions of individual A-pocket amino acids to the binding of A-4 and A-10 in different halves of the dimer. Various substitutions of A-pocket residues were introduced into one half of single-chain coat protein heterodimers where they were tested for their abilities to complement Y85H or T91I substitutions (defects in the A-4 and A-10 half-sites, respectively) present in the other dimer half.
        
        
          Conclusions
          These experiments provide functional tests of interactions predicted from structural analyses, demonstrating the importance of certain amino acid-nucleotide contacts observed in the crystal structure, and showing that others make little or no contribution to the stability of the complex. In summary, Val29 and Lys61 form important stabilizing interactions with both A-4 and A-10. Meanwhile, Ser47 and Thr59 interact primarily with A-10. The important interactions with Thr45 are restricted to A-4.

Tags: adenosine-binding, ms2-coat-protein, nih, protein-dimer
Organization: U.S. Department of Health & Human Services
Tribal Courts and Child Welfare: Adapting to Child Welfare Cases

This Child Welfare Information Gateway Podcast is available on Apple Podcasts
  
  

, GooglePlay
  
  

, Spotify
  
  

, Stitcher
  
  

, SoundCloud
  
  

, and the Child Welfare Information Gateway
  
  

 website. Subscribe to receive new episodes as they are released.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: child, law, legal, policy, sery
Organization: U.S. Department of Health & Human Services
2019 NSDUH Detailed Tables

Get detailed national estimates from the 2018 and 2019 National Surveys on Drug Use and Health (NSDUH). The tables provide comprehensive statistics on substance use, mental health, and treatment in the United States. Longer-term trends are also available for select indicators.The tables are based on the NSDUH survey, which interviews people ages 12 or older in the civilian, noninstitutionalized population. In the tables, indicators are broken out by a variety of demographic, geographic, and economic variables.The following topics are covered, among others: drug, alcohol, nicotine, and tobacco product use and initiation; substance use disorder (SUD); substance use risk and protective factors; availability of substance use treatment; any mental illness (AMI) and serious mental illness (SMI); major depressive episode (MDE); suicidal thoughts and behaviors; serious psychological distress (SPD); mental health service utilization; treatment for depression; and co-occurrence of mental health issues and SUDs.All of the tables can be downloaded in a zip file which contains both an html and PDF file containing every table. Alternatively, users can open the clickable Table of Contents to go to a particular section. Click on “PE” to get to a population estimate or percentage table, and “SE” to get a standard error table.

Tags: ami-smi, mental-health, samhsa, substance-use, suicidal-ideation
Organization: U.S. Department of Health & Human Services
Publications Using SAMHSA DataNational Directory of Mental Health Treatment Facilities

TheNational Directory of Mental Health Treatment Facilities - 2021is a listing of federal, state, and local government facilities and private facilities that provide mental health treatment services. It includes treatment facilities that responded to the 2020 National Mental Health Services Survey (N-MHSS). The information about each facility that appears in this Directory was provided by that facility in response to the 2020 N-MHSS. The N-MHSS is conducted annually by the Substance Abuse and Mental Health Services Administration (SAMHSA).The Directory is ordered alphabetically by state, by city within each state, and by facility name within each city. Each facility listing includes codes that represent the services offered and other features of the facility, including codes that indicate services for hearing impaired and non-English-speaking clients. Codes are defined in a key shown on pages v-ix. Because the services offered by a particular facility may change over time, it is always a good idea to verify the information in this Directory when contacting a facility.

Tags: behavioral-health, facility-directory, mental-health-services, samhsa, treatment-facilities
Organization: U.S. Department of Health & Human Services
2011 CMHS Uniform Reporting System (URS) Output Tables for Oregon

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2011. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, oregon, outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
2020 Triennial Process Evaluation Report Of The Projects For Assistance In Transition From Homelessness Program (PATH)

SAMHSA’s Projects for Assistance in Transition from Homelessness (PATH) program was created to reduce or eliminate homelessness and imminent risk of homelessness for individuals with serious mental illness or co-occurring mental and substance use disorders.  The2020 Triennial Process Evaluation Report of the Projects for Assistance in Transition from Homelessness Program  (PATH)looks at the PATH program data from 2016, 2017, and 2018 to ensure that the services provided were appropriate and well-administered by the grantees. PATH is administered by the Division of State and Community Systems Development of the Center for Mental Health Services (CMHS) and the evaluation was conducted by the Center for Behavioral Health Services and Quality’s Office of Evaluation.

Tags: homelessness-services, mental-health, program-evaluation, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
2015 National Survey on Drug Use and Health:  Methodological Summary and Definitions

This report summarizes methods and other supporting information that are relevant to estimates of substance use and mental health issues from the 2015 National Survey on Drug Use and Health (NSDUH), an annual survey of the civilian, noninstitutionalized population of the United States aged 12 years old or older. Section A describes the survey, including information about the sample design, data collection procedures, and key aspects of data processing (e.g., development of analysis weights). Section B presents technical details on the statistical methods and measurement, such as suppression criteria for unreliable estimates, statistical testing procedures, and issues for selected substance use and mental health measures.  Section C describes changes that were made to the 2015 NSDUH questionnaire and the effects of these changes on the comparability of estimates between 2015 and earlier years. A glossary that covers key definitions used in NSDUH reports and tables is included in Section D. Section E describes other sources of data on substance use and mental health issues, including data sources for populations outside the NSDUH target population. A list of references cited in the report (Section F) and contributors to this report (Section G) also are provided.

Tags: mental-health, nsduh, samhsa, substance-use, survey-methodology
Organization: U.S. Department of Health & Human Services
Mechanisms of bone loss in inflammatory arthritis: diagnosis and		  therapeutic implications

Rheumatoid arthritis represents an excellent model in which to gain			 insights into the local and systemic effects of joint inflammation on skeletal			 tissues. Three forms of bone disease have been described in rheumatoid			 arthritis. These include: focal bone loss affecting the immediate subchondral			 bone and bone at the joint margins; periarticular osteopenia adjacent to			 inflamed joints; and generalized osteoporosis involving the axial and			 appendicular skeleton. Although these three forms of bone loss have several			 features in common, careful histomorphometric and histopathological analysis of			 bone tissues from different skeletal sites, as well as the use of urinary and			 serum biochemical markers of bone remodeling, provide compelling evidence that			 different mechanisms are involved in their pathogenesis. An understanding of			 these distinct pathological forms of bone loss has relevance not only with			 respect to gaining insights into the different pathological mechanisms, but			 also for developing specific and effective strategies for preventing the			 different forms of bone loss in rheumatoid arthritis.

Tags: bone-loss, joint-inflammation, nih, osteoporosis, rheumatoid-arthritis
Organization: U.S. Department of Health & Human Services
Evidence for symmetric chromosomal inversions around the replication origin in bacteria

Background:
          Whole-genome comparisons can provide great insight into many aspects of biology. Until recently, however, comparisons were mainly possible only between distantly related species. Complete genome sequences are now becoming available from multiple sets of closely related strains or species.
        
        
          Results:
          By comparing the recently completed genome sequences of Vibrio cholerae,						Streptococcus pneumoniae and Mycobacterium tuberculosis to those of closely related species - Escherichia coli, Streptococcus pyogenes and Mycobacterium leprae, respectively - we have identified an unusual and previously unobserved feature of bacterial genome structure. Scatterplots of the conserved sequences (both DNA and protein) between each pair of species produce a distinct X-shaped pattern, which we call an X-alignment. The key feature of these alignments is that they have symmetry around the replication origin and terminus; that is, the distance of a particular conserved feature (DNA or protein) from the replication origin (or terminus) is conserved between closely related pairs of species. Statistically significant X-alignments are also found within some genomes, indicating that there is symmetry about the replication origin for paralogous features as well.
        
        
          Conclusions:
          The most likely mechanism of generation of X-alignments involves large chromosomal inversions that reverse the genomic sequence symmetrically around the origin of replication. The finding of these X-alignments between many pairs of species suggests that chromosomal inversions around the origin are a common feature of bacterial genome evolution.

Tags: bacterial-genomes, chromosomal-inversions, genome-comparison, nih, replication-origin
Organization: U.S. Department of Health & Human Services
2014 CMHS Uniform Reporting System (URS) Table for Iowa

2014 Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for Iowa. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant, iowa, mental-health-services, outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
2011 State Profile — Tennessee

This is a National Survey of Substance Abuse Treatment Services (N-SSATS) data table showing state profiles for Tennessee in 2011. N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 States, the District of Columbia, and other U.S. jurisdictions.

Tags: n-ssats, samhsa, substance-abuse-treatment, tennessee, treatment-facilities
Organization: U.S. Department of Health & Human Services
2012 State Profile - South Carolina

This is a National Survey of Substance Abuse Treatment Services (N-SSATS) annual report showing the state profile for South Carolina in 2012. N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 States, the District of Columbia, and other U.S. jurisdictions.

Tags: alcohol-drug-abuse, n-ssats, samhsa, south-carolina, substance-abuse-treatment
Organization: U.S. Department of Health & Human Services
4.12a Facilities offering services in sign language for the hearing impaired and in languages other than English, by facility operation and primary focus of facility: 2011. Number

This is a National Survey of Substance Abuse Treatment Services (N-SSATS) data table showing facilities offering services in sign language for the hearing impaired and in languages other than English, by facility operation and primary focus of facility in 2011. N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 States, the District of Columbia, and other U.S. jurisdictions.

Tags: hearing-impaired, language-access, samhsa, sign-language-services, substance-abuse-treatment
Organization: U.S. Department of Health & Human Services
Compound 527245: 2,2,2-Trichloroethyl nonanoate

Chemical compound data from PubChem database. IUPAC Name: 2,2,2-trichloroethyl nonanoate. Molecular Formula: C11H19Cl3O2. Molecular Weight: 289.6. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services