AndreaBozzo/ceres-open-data-index huggingface dataset:
The families evaluation on management, care and disclosure for terminal stage cancer patients

Background
          Quality of life is an important concept which is subjective and personal; what is an acceptable quality of life to one may be 'worse than death' to another. The objective of this study was to develop and validate a questionnaire to assess relatives' perceptions and attitudes towards their terminal stage cancer patients' management (information disclosure, treatment choice, hospitalization and support-communication and care) including aspects regarding end-of-life and quality-of-life decisions.
        
        
          Methods
          The final study consisted of 146 relatives of advanced terminal stage cancer patients receiving palliation, attending a Pain Relief and Palliative Care Unit. The questionnaire incorporated 6 multi-item and 7 single-item scales, and was developed following a systematic review of measures appropriate for use in palliative care settings.
        
        
          Results
          Following analysis of the 25-item scale, the questionnaire has been validated as a shortened 21-item scale consisting of 5 multi-item and 5 single-item scales. Factor analysis was based upon information disclosure, hospitalization, and support-communication demonstrating Cronbach's alpha coefficients of 0.66, 0.5 and 0.70 respectively. Average item totals and inter-item scale correlations were between 0.62–0.70, with convergent validity correlations between 0.60–0.86. The questionnaire was well accepted by all subjects with an 8–10 minute completion time.
        
        
          Conclusion
          The shortened 21-item self-assessment questionnaire may provide acceptable and valid assessment of caregiver(s)/Greek cancer patients' relatives perceptions on palliative care.

Tags: end-of-life, family-perception, nih, palliative-care, terminal-cancer
Organization: U.S. Department of Health & Human Services
2011 Opioid Treatment Program (OTP) Survey

This is an annual report explaining the Opioid Treatment Program (OTP) survey for 2011. This report represents a census of all SAMHSA-certified OTPs in the United States, both public and private, and presents both highlights and tabular information from the 2011 Opioid Treatment Program (OTP) Survey. The OTP survey was fielded in conjunction with SAMHSA’s National Survey of Substance Abuse Treatment Services (N-SSATS). N-SSATS is an annual census of all known facilities providing substance abuse treatment. It is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 states, the District of Columbia, and other U.S. jurisdictions.

Tags: opioid-treatment, otp-survey, samhsa, substance-abuse, treatment-services
Organization: U.S. Department of Health & Human Services
Compound 527371: 20,24,28-Trimethyl-hentriacontyl cyanide

Chemical compound data from PubChem database. IUPAC Name: 21,25,29-trimethyldotriacontanenitrile. Molecular Formula: C35H69N. Molecular Weight: 503.9. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Phoenix-Mesa-Glendale, AZ

This report presents combined 2005 to 2010 National Survey on Drug Use and Health (NSDUH) results for those aged 12 or older in the Phoenix-Mesa-Glendale, AZ metro area. The report includes estimates of substance use disorder, major depressive episode, illicit drug use, marijuana use, cigarette use, binge alcohol use, and the nonmedical use of prescription-type pain relievers. Results are provided for the Phoenix-Mesa-Glendale metro area, Arizona, and the U.S. overall.

Tags: arizona, drug-use, major-depressive-episode, samhsa, substance-use-disorder
Organization: U.S. Department of Health & Human Services
Compound 527253: 4,6-Dimethyloctane-3,5-dione

Chemical compound data from PubChem database. IUPAC Name: 4,6-dimethyloctane-3,5-dione. Molecular Formula: C10H18O2. Molecular Weight: 170.25. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 525674: N-(4-Bromobenzylidene)aniline

Chemical compound data from PubChem database. IUPAC Name: 1-(4-bromophenyl)-N-phenylmethanimine. Molecular Formula: C13H10BrN. Molecular Weight: 260.13. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 525443: 3,9-Dithiadecane

Chemical compound data from PubChem database. IUPAC Name: 1-ethylsulfanyl-5-methylsulfanylpentane. Molecular Formula: C8H18S2. Molecular Weight: 178.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2013 NSDUH Risk and Protective Factors Tables (Standard Errors and P Values) - 3.1 to 3.25

These detailed tables present standard errors for totals and prevalence estimates of risk and protective factors regarding substance use from the 2013 National Survey on Drug Use and Health (NSDUH). The factors include perceptions of 1) risk of substance use, 2) availability of substances, 3) parental disapproval of youth substance use, 4) peer substance use. These factors include measures of delinquent behavior, religious involvement, exposure to prevention messages, and parental involvement. Standard errors are provided by age group, gender, race/ethnicity, geographic area, and youth substance use behavior. Standard errors are provided for both 2013 and 2012.

Tags: nsduh-2013, protective-factors, samhsa, substance-use-risk, youth-drug-use
Organization: U.S. Department of Health & Human Services
Table 18. Illicit Drug Dependence or Abuse in the Past Year, by Age Group and State: Percentages, Annual Averages Based on 2013 and 2014 NSDUHs

Table 18. Illicit Drug Dependence or Abuse in the Past Year, by Age Group and State: Percentages, Annual Averages Based on 2013 and 2014 NSDUHs

Tags: drug-dependence, illicit-drug-abuse, nsduh-data, samhsa, substance-use-disorder
Organization: U.S. Department of Health & Human Services
Reliability, validity and psychometric properties of the Greek translation of the zung depression rating scale

Introduction
          The current study aimed to assess the reliability, validity and psychometric properties of the Greek translation of the Zung Depression Rating Scale (ZDRS).
        
        
          Methods
          The study sample included 40 depressed patients 29.65 ± 9.38 years old and 120 normal comparison subjects 27.23 ± 10.62 years old. In 20 of them (12 patients and 8 comparison subjects) the instrument was re-applied 1–2 days later. Translation and Back Translation was made. Clinical Diagnosis was reached by consensus of two examiners with the use of the SCAN v.2.0 and the IPDE. Statistical Analysis included ANOVA, the Pearson Product Moment Correlation Coefficient, Principal Components Analysis and Discriminant Function Analysis and the calculation of Cronbach's alpha (α)
        
        
          Results
          Both Sensitivity and specificity exceed 90.00 at 44/45, Chronbach's alpha for the total scale was equal to 0.09, suggesting that the scale covers a broad spectrum of symptoms. Factor analysis revealed five factors (anxiety-depression, thought content, gastrenterological symptoms, irritability and social-interpersonal functioning). The test-retest reliability was satisfactory (Pearson's R between 0.92).
        
        
          Conclusion
          The ZDRS-Greek translation is both reliable and valid and is suitable for clinical and research use with satisfactory properties. Its properties are similar to those reported in the international literature, although the literature is limited. However one should always have in mind the limitations inherent in the use of self-report scales.

Tags: depression-screening, greek-translation, nih, psychometric-properties, zung-depression-scale
Organization: U.S. Department of Health & Human Services
Arkansas 2016 Potential Areas for Addressing Service Gaps for Opioid Treatment

The purpose of the medication-assisted treatment (MAT) facility maps is to identify areas on a state-by-state basis that may be potentially underserved by existing treatment facilities. The maps are created with a methodology that seeks to include the highest potential need areas from individual counties so that county-level stakeholders are also informed. The maps are meant to be used as a tool for policy makers to determine potentially underserved areas—not as a definitive representation of these areas.

Tags: arkansas-opioids, mat-access, opioid-treatment, samhsa, service-gap-analysis
Organization: U.S. Department of Health & Human Services
A revival of the B cell paradigm for rheumatoid arthritis pathogenesis?

Dominant paradigms for the understanding of rheumatoid arthritis (RA) pathogenesis have changed over the years. A predominant role of B lymphocytes, and perhaps of the rheumatoid factor they produced, was initially invoked. In more recent years, recognition of antigens in the joint by T cells sparking an inflammatory cascade has been a more favored interpretation. Here, we re-examine some of the arguments that underpin this proposed role of joint T cells, in light of recent results from transgenic mice in which a self-reactive T-cell receptor provokes disease, but from outside the joint and indirectly via B lymphocytes and immunoglobulins.

Tags: b-lymphocytes, immunoglobulins, nih, rheumatoid-arthritis, t-lymphocytes
Organization: U.S. Department of Health & Human Services
Paying for Behavioral Health Treatment: The Role of the Affordable Care Act

The Affordable Care Act (ACA) extended dependent care coverage to all individuals under age 26.  The coverage expansion in 2010 likely caused an increase in private insurance coverage and mental health treatment use for young adults.  For mental health and substance use treatment, changes in who pays for care can be evaluated using the Medical Expenditure Panel Survey (MEPS).  Annual data from 2004 to 2012 were used to determine the average treatment payments by payer type before and after the dependent care expansion for all individuals aged 19-26 who reported treatment for mental health or substance use issues.  Costs are presented in this spotlight.

Tags: aca-impact, behavioral-health-spending, meps-data, samhsa, young-adults-mental-health
Organization: U.S. Department of Health & Human Services
A new model for rheumatoid arthritis?

A chance observation has led to the development of a new murine model for inflammatory arthritis. Arthritis is induced, and transferred, by T-cell-dependent antibodies to glucose-6-phosphate isomerase. This enzyme is expressed in all cells, and is detectable in serum. There are several similarities to rheumatoid arthritis (RA) in the murine disease. This elegant model raises several questions as to how and why a systemic response focuses inflammation so strongly on synovial joints. The model also re-introduces the possibility that antibodies to widely expressed self-proteins may play a role in the pathogenesis of RA.

Tags: antibody-mediated-arthritis, glucose-6-phosphate-isomerase, murine-model, nih, rheumatoid-arthritis
Organization: U.S. Department of Health & Human Services
Table 13. Binge Alcohol Use in the Past Month among Persons Aged 12 to 20, by State and Substate Regions: Percentages, Annual Averages Based on 2008, 2009, and 2010 NSDUHs

This table presents the 2008 to 2010 National Survey on Drug Use and Health (NSDUH) estimates of past month binge alcohol use by those aged 12 to 20 in State and substate regions.

Tags: adolescent-alcohol-use, binge-drinking, nsduh, samhsa, substate-data
Organization: U.S. Department of Health & Human Services
National Survey of Substance Abuse Treatment Services: State Profiles 2005

The 2005 National Survey of Substance Abuse Treatment Services (N-SSATS) is an annual survey of facilities providing substance abuse treatment. The N-SSATS, conducted by the Substance Abuse and Mental Health Services Administration (SAMHSA), is designed to collect data on the location, characteristics, services offered, and number of clients in treatment at alcohol and drug abuse facilities (both public and private) throughout the 50 states, the District of Columbia, and other U.S. jurisdictions.

Tags: addiction-services, n-ssats, samhsa, substance-abuse-treatment, treatment-facilities
Organization: U.S. Department of Health & Human Services
2011 NSDUH Statistical Inference Report

This report describes the statistical inference procedures used to produce design-based estimates for the 2011 National Survey on Drug Use and Health (NSDUH). These design-based estimates are presented in the 2011 national findings report detailed tables, as well as the 2011 mental health findings report and detailed tables.

Tags: mental-health, samhsa, statistical-methods, substance-use, survey-methodology
Organization: U.S. Department of Health & Human Services
What you should know about PR3-ANCA: Evidence for the role of T cells in the pathogenesis of systemic vasculitis

The pathogenesis of systemic vasculitis is complex and is likely to involve many mechanisms. There is a growing body of evidence that T cells may contribute to the pathogenesis of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides. Predominantly, T cells and monocytes are found in inflammatory infiltrates in patients with Wegener's granulomatosis (WG). The production of ANCA appears to be T-cell-dependent. T lymphocytes from the peripheral blood of patients with ANCA-associated vasculitis have been shown to proliferate in response to proteinase 3 (PR3). These and other findings outlined in this review indicate T-cell involvement, although further studies are still needed to elucidate the exact contribution of T cells to the pathogenesis of systemic vasculitis.

Tags: anca-associated-vasculitis, nih, proteinase-3, t-cell-response, wegeners-granulomatosis
Organization: U.S. Department of Health & Human Services
National Survey of Substance Abuse Treatment Services: State Profiles 2012

The 2012 National Survey of Substance Abuse Treatment Services (N-SSATS) is an annual survey of facilities providing substance abuse treatment. The N-SSATS, conducted by the Substance Abuse and Mental Health Services Administration (SAMHSA), is designed to collect data on the location, characteristics, services offered, and number of clients in treatment at alcohol and drug abuse facilities (both public and private) throughout the 50 states, the District of Columbia, and other U.S. jurisdictions.

Tags: alcohol-drug-abuse, n-ssats, samhsa, substance-abuse-treatment, treatment-facilities
Organization: U.S. Department of Health & Human Services
Suppression of murine collagen-induced arthritis by targeted apoptosis of synovial neovasculature

Because angiogenesis plays a major role in the perpetuation of inflammatory arthritis, we explored a method for selectively targeting and destroying new synovial blood vessels. Mice with collagen-induced arthritis were injected intravenously with phage expressing an RGD motif. In addition, the RGD peptide (RGD-4C) was covalently linked to a proapoptotic heptapeptide dimer, D(KLAKLAK)2, and was systemically administered to mice with collagen-induced arthritis. A phage displaying an RGD-containing cyclic peptide (RGD-4C) that binds selectively to the αvβ3 and αvβ5 integrins accumulated in inflamed synovium but not in normal synovium. Homing of RGD-4C phage to inflamed synovium was inhibited by co-administration of soluble RGD-4C. Intravenous injections of the RGD-4C–D(KLAKLAK)2 chimeric peptide significantly decreased clinical arthritis and increased apoptosis of synovial blood vessels, whereas treatment with vehicle or uncoupled mixture of the RGD-4C and the untargeted proapoptotic peptide had no effect. Targeted apoptosis of synovial neovasculature can induce apoptosis and suppress clinical arthritis. This form of therapy has potential utility in the treatment of inflammatory arthritis.

Tags: collagen-induced-arthritis, murine-model, nih, synovial-neovasculature, targeted-apoptosis
Organization: U.S. Department of Health & Human Services
National Survey of Substance Abuse Treatment Services: State Profiles 2008

The 2008 National Survey of Substance Abuse Treatment Services (N-SSATS) is an annual survey of facilities providing substance abuse treatment. The N-SSATS, conducted by the Substance Abuse and Mental Health Services Administration (SAMHSA), is designed to collect data on the location, characteristics, services offered, and number of clients in treatment at alcohol and drug abuse facilities (both public and private) throughout the 50 states, the District of Columbia, and other U.S. jurisdictions.

Tags: alcohol-drug-abuse, mental-health-services, samhsa, substance-abuse-treatment, treatment-facility-survey
Organization: U.S. Department of Health & Human Services
Underage Drinking Declined Between 2002 and 2013

This report uses 2002 to 2013 National Survey on Drug Use and Health (NSDUH) to assess trends in underage (12 to 20 year olds) past month alcohol use and binge alcohol use.

Tags: alcohol-use, nsduh-data, samhsa, underage-drinking, youth-substance-use
Organization: U.S. Department of Health & Human Services
2010 State Profile — Colorado

This state profile includes data from facilities in Colorado that reported to N-SSATS for the survey reference date March 31, 2010. Data were collected on the location, characteristics, services offered, and number of clients in treatment at alcohol and drug abuse treatment facilities (both public and private) in Colorado. In Colorado, 437 substance abuse treatment facilities were included in the 2010 N-SSATS, reporting that there were 39,749 clients in substance abuse treatment on March 31, 2010. The survey response rate in Colorado was 88.3%.

Tags: addiction-services, colorado, n-ssats, samhsa, substance-abuse-treatment
Organization: U.S. Department of Health & Human Services
Biventricular pacing in heart failure: update on results from clinical trials

Biventricular pacing or resynchronisation therapy is a non-pharmacological therapy for patients with chronic heart failure. Since being originally described in 1994, biventricular pacing has become a subject of intense interest and investigation. This review analyses the results reported in observational series and randomised trials, and seeks to answer two questions. If it works, why does it work? Which heart failure patients will it benefit?

Tags: biventricular-pacing, cardiac-resynchronization, clinical-trials, heart-failure, nih
Organization: U.S. Department of Health & Human Services
Importance of the TIMI frame count: implications for future trials

Although the TIMI (Thrombolysis In Myocardial Infarction) flow grade classification scheme is widely used to assess angiographic outcomes, it is limited by poor reproducibility and its categoric nature. The corrected TIMI frame count (CTFC) is a simple, more objective continuous variable index of coronary blood flow that can be broadly and inexpensively applied. This measure of the time for dye to traverse a coronary artery is both accurate (highly correlated with Doppler velocity measurements) and precise (reproducible). The method has been prospectively validated as providing independent risk stratification above and beyond the conventional TIMI flow grades. It has been shown to be a predictor of restenosis, and has been of value in elucidating the underlying pathophysiology of acute myocardial infarction. In view of the above and its ease of use, we anticipate that CTFC will become a widely used method to evaluate coronary blood flow.

Tags: angiographic-outcomes, coronary-blood-flow, myocardial-infarction, nih, timi-frame-count
Organization: U.S. Department of Health & Human Services
2010 CMHS Uniform Reporting System (URS) Output Tables for Washington

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2010. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-program, community-mental-health, mental-health-services, noms-measures, samhsa
Organization: U.S. Department of Health & Human Services
Reversible renal impairment induced by treatment with the angiotensin II receptor antagonist candesartan in a patient with bilateral renal artery stenosis

Background
          It is well established that ACE-inhibitors should be avoided in patients with renal artery stenosis. In recent years it has also been recommended that caution should be demonstrated when angiotensin II blockers are used in the same type of patients but the evidence is based only on few cases.
        
        
          Results
          We describe a case where use of the angiotensin II antagonist candesartan (Atacand) induced renal failure in a patient with bilateral renal artery stenosis. The course of the case is enlighted by results from sequential renography, selective renal vein catheterisation for measurement of renin, and angiographic findings.
        
        
          Conclusions
          In patients with renal artery stenosis the angiotensin II antagonist candesartan should be avoided.

Tags: angiotensin-ii-antagonist, candesartan, nih, renal-artery-stenosis, renal-impairment
Organization: U.S. Department of Health & Human Services
Publications Using SAMHSA DataNSDUH 2020 Web Questionnaire

The 2020 NSDUH web interview questionnaire was administered in Quarter 4 2020. A summary of questionnaire changes is located within the first few pages. The table of contents allows you to jump to particular sections.

Tags: behavioral-health, mental-health, samhsa, substance-use, web-survey
Organization: U.S. Department of Health & Human Services