AndreaBozzo/ceres-open-data-index huggingface dataset:
Plant growth regulatory effect and insecticidal activity of the extracts of the Tree of Heaven (

Background
          There is an urgent need to explore and utilize naturally occurring products for combating harmful agricultural and public health pests. Secondary metabolites in the leaves of the Tree of Heaven, Ailanthus altissima L. have been reported to be herbicidal and insecticidal. The mode of action, however, of the active compounds in A. altissima are not understood. In this paper, we report the chemical characteristics of the herbicidal and insecticidal components in this tree, and will discuss the effect of light on the bioactivity of the active components.
        
        
          Results
          Extracts from the fresh leaves of A. altissima showed a strong plant germination/growth inhibitory effect in laboratory bioassays against alfalfa (Medicago sativa). The effect was dose-dependent. The growth inhibitory components were in the methylene chloride soluble fraction of the extract. The effect was greater in the light than in the dark. Other fractions had plant growth enhancing effect at lower concentrations. The extract was slightly insecticidal against yellow fever mosquito larvae (Aedes aegypti).
        
        
          Conclusions
          The extract or its semi-purified fractions of A. altissima were strong plant growth inhibitors, therefore good candidates as potential environmentally safe and effective agricultural pest management agents. The finding that light affects the activity will be useful in the application of such natural products.

Tags: ailanthus-altissima, herbicidal-effects, insecticidal-activity, nih, plant-growth-regulation
Organization: U.S. Department of Health & Human Services
Compound 525284: N'-Phenyl-N,N-dimethyl-acetamidine

Chemical compound data from PubChem database. IUPAC Name: N,N-dimethyl-N'-phenylethanimidamide. Molecular Formula: C10H14N2. Molecular Weight: 162.23. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Dimerization of Receptor Protein-Tyrosine Phosphatase alpha in living cells

Background
          Dimerization is an important regulatory mechanism of single membrane-spanning receptors. For instance, activation of receptor protein-tyrosine kinases (RPTKs) involves dimerization. Structural, functional and biochemical studies suggested that the enzymatic counterparts of RPTKs, the receptor protein-tyrosine phosphatases (RPTPs), are inhibited by dimerization, but whether RPTPs actually dimerize in living cells remained to be determined.
        
        
          Results
          In order to assess RPTP dimerization, we have assayed Fluorescence Resonance Energy Transfer (FRET) between chimeric proteins of cyan- and yellow-emitting derivatives of green fluorescent protein, fused to RPTPα, using three different techniques: dual wavelength excitation, spectral imaging and fluorescence lifetime imaging. All three techniques suggested that FRET occurred between RPTPα -CFP and -YFP fusion proteins, and thus that RPTPα dimerized in living cells. RPTPα dimerization was constitutive, extensive and specific. RPTPα dimerization was consistent with cross-linking experiments, using a non-cell-permeable chemical cross-linker. Using a panel of deletion mutants, we found that the transmembrane domain was required and sufficient for dimerization.
        
        
          Conclusions
          We demonstrate here that RPTPα dimerized constitutively in living cells, which may be mediated by the transmembrane domain, providing strong support for the model that dimerization is involved in regulation of RPTPs.

Tags: fluorescence-microscopy, fret-analysis, nih, protein-tyrosine-phosphatase, receptor-dimerization
Organization: U.S. Department of Health & Human Services
Structural model of nicotinic acetylcholine receptor isotypes bound to acetylcholine and nicotine

Background
          Nicotine is a psychoactive drug presenting a diverse array of biological activities, some positive, such as enhancement of cognitive performances, others negative, such as addiction liability. Ligands that discriminate between the different isotypes of nicotinic acetylcholine receptors (nAChRs) could present improved pharmacology and toxicity profile.
        
        
          Results
          Based on the recent crystal structure of a soluble acetylcholine binding protein from snails, we have built atomic models of acetylcholine and nicotine bound to the pocket of four different human nAChR subtypes. The structures of the docked ligands correlate with available biochemical data, and reveal that the determinants for isotype selectivity are relying essentially on four residues, providing diversity of the ligand binding pocket both in terms of Van der Waals boundary, and electrostatic potential. We used our models to screen in silico a large compound database and identify a new ligand candidate that could display subtype selectivity.
        
        
          Conclusion
          The nAChR-agonist models should be useful for the design of nAChR agonists with diverse specificity profiles.

Tags: acetylcholine-binding, nicotine-binding, nicotinic-receptors, nih, receptor-isotypes
Organization: U.S. Department of Health & Human Services
2021 Uniform Reporting System (URS) Table For Minnesota

This is the 2021 Uniform Reporting System (URS) Output Tables for Minnesota. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, minnesota, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Percutaneous tracheostomy: comparison of Ciaglia and Griggs
		  techniques

Background:
          Although the standard tracheostomy described in 1909 by Jackson
				has been extensively used in critical patients, a more simple procedure that
				can be performed at the bedside is needed. Since 1957 several different types
				of percutaneous tracheostomy technique have been described. The purpose of the
				present study was to compare two bedside percutaneous tracheostomy techniques:
				percutaneous dilatational tracheostomy (PDT) and the guidewire dilating forceps
				(GWDF).
        
        
          Materials and methods:
          A prospective study in two medical/surgical intensive care units
				(ICUs) was carried out. Sixty-three critically ill patients who required
				endotracheal intubation for longer than 15 days were consecutively selected to
				undergo PDT (25 patients) or GWDF (38 patients) technique. Intraoperative and
				postoperative complications were recorded.
        
        
          Results:
          Age (mean ± standard error) was 63 ± 1.1 years. The
				patients had been mechanically ventilated for an average of 19.8 ± 1.2
				days. The GWDF technique was significantly faster than PDT technique
				(P = 0.02). Fifteen complications occurred in 10 out of 63 (15%)
				patients. They were as follows: tracheal tear (one patient in each group; in
				one case this was due to false passage); transient hypotension (one patient in
				the PDT group and two patients in the GWDF group); atelectasis (one patient in
				the PDT group); and haemorrhage (one patient in the PDT group and three
				patients in the GWDF group). In both patients with tracheal tear, reduced
				arterial oxygen saturation (SaO2) with concomitant subcutaneous
				emphysema ensued.
        
        
          Conclusion:
          We found no statistical differences between complications with
				both techniques. The surgical time required for the GWDF technique was less
				than that for PDT.

Tags: ciaglia-technique, critical-care, griggs-technique, nih, percutaneous-tracheostomy
Organization: U.S. Department of Health & Human Services
1 in 7 Adolescents with Diabetes Experienced a Major Depressive Episode in the Past Year

This spotlight uses 2005 to 2015 National Surveys on Drug Use and Health (NSDUH) data to examine the association between diabetes and depression among adolescents aged 12 to 17.

Tags: adolescent-depression, comorbidity, diabetes-mental-health, nsduh-data, samhsa
Organization: U.S. Department of Health & Human Services
2013 CMHS Uniform Reporting System (URS) Table for Nevada

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Tables for Nevada for 2013. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program.  State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, national-outcome-measures, nevada-mental-health, samhsa
Organization: U.S. Department of Health & Human Services
Compound 525371: 2,4,5-Trimethyl-3-thiahexane

Chemical compound data from PubChem database. IUPAC Name: 2-methyl-3-propan-2-ylsulfanylbutane. Molecular Formula: C8H18S. Molecular Weight: 146.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Bridging case-control studies and randomized trials

Randomized trials and observational studies, such as case-control studies, are often seen as opposing approaches. However, in many instances results obtained by different designs may complement each other. For instance, case-control studies on aetiology of disease may help to give the direction of future trials. In this commentary, the author discusses the purpose of randomization and observation, and under which conditions one design may be preferred to another. Randomization is useful to combat 'confounding by indication', and is therefore the design of choice for most therapeutic trials. When this confounding is not an issue, as in studies of genetic risk factors or side-effects, then case-control studies are preferred.

Tags: case-control-study, genetic-risk-factors, nih, randomized-trials, therapeutic-trials
Organization: U.S. Department of Health & Human Services
2017 Uniform Reporting System (URS) Table for Puerto Rico

This is the 2017 Uniform Reporting System (URS) Output Tables for Puerto Rico. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-program, mental-health-services, national-outcome-measures, puerto-rico, samhsa
Organization: U.S. Department of Health & Human Services
2020 Mental Health Client-Level Data (MH-CLD) Annual Report

This report presents results from the Mental Health Client-Level Data (MH-CLD) and Mental Health Treatment Episode Data Set (MH-TEDS) for individuals receiving mental health services from state mental health systems in 2020, as well as selected trends in data collected from such individuals between 2015 and 2020. The report provides information on mental health diagnoses, mental health treatment settings, and demographic and substance use characteristics of individuals in mental health treatment in facilities that reported to individual state administrative data systems.

Tags: mental-health-diagnosis, mental-health-services, samhsa, substance-use-disorders, treatment-episodes
Organization: U.S. Department of Health & Human Services
2022 Uniform Reporting System (URS) Table For New Hampshire

This is the 2022 Uniform Reporting System (URS) Output Tables for New Hampshire. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-data, evidence-based-practices, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
2022 Uniform Reporting System (URS) Table For Kansas

This is the 2022 Uniform Reporting System (URS) Output Tables for Kansas. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-data, kansas, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
β1 integrins show specific association with CD98 protein in low density membranes

Background
          The CD98 (4F2, FRP-1) is a widely expressed cell surface protein heterodimer composed of a glycosylated heavy chain and a non-glycosylated light chain. Originally described as a T cell activation antigen, it was later shown to function in amino acid transport, cell fusion and homotypic cell aggregation. Several lines of evidence suggest its functional interaction with integrins but the biochemical basis for this interaction has been unclear.
        
        
          Results
          We demonstrate that CD98 constitutively and specifically associates with β1 integrins (α2β1,α3β1, α5β1 and α6β1), but minimally with α4β1. Integrin-CD98 association was established by reciprocal immunoprecipitation experiments, and confirmed by CD98-induced clustering of α3β1 but not α4β1 on the surface of rhabdomyosarcoma cells. Integrin-CD98 association is independent of the α subunit cytoplasmic tail, is maintained in α3β1 ligand-interaction deficient mutants, and is not inhibited by EDTA. Within the CD98 heavy chain, a C109S mutation (but not a C330S mutation) caused a loss of β1 integrin association. The same C109S mutation also caused a loss of CD98 light chain association. Importantly, CD98 associated selectively with β1 integrins present in low density "light membrane" fractions on a sucrose gradient. CD98 was not present in dense fractions that contained the majority of β1 integrins. Notably, the C109S mutant of CD98, that did not associate with β1 integrins, showed also a reduced localization into light membrane fractions.
        
        
          Conclusions
          We demonstrate that CD98 association with β1 integrins is specific, occurs in the context of low density membranes, and may require the CD98 light chain.

Tags: beta1-integrins, cell-surface-proteins, integrin-cd98-association, nih, protein-interaction-mapping
Organization: U.S. Department of Health & Human Services
District of Columbia (DC)

This report presents the District of Columbi\'s estimates for 25 measures of substance use and mental health based on the combined 2009 and 2010 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for the District of Columbia for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: dc-health, mental-health, nsduh-data, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Janus kinases and signal transducers and activators of transcription:		  their roles in cytokine signaling, development and immunoregulation

Cytokines play a critical role in the normal development and			 function of the immune system. On the other hand, many rheumatologic diseases			 are characterized by poorly controlled responses to or dysregulated production			 of these mediators. Over the past decade tremendous strides have been made in			 clarifying how cytokines transmit signals via pathways using the Janus kinase			 (Jak) protein tyrosine kinases and the Signal transducer and activator of			 transcription (Stat) proteins. More recently, research has focused on several			 distinct proteins responsible for inhibiting these pathways. It is hoped that			 further elucidation of cytokine signaling through these pathways will not only			 allow for a better comprehension of the etiopathogenesis of rheumatologic			 illnesses, but may also direct future treatment options.

Tags: cytokine-signaling, immunoregulation, jak-stat-pathway, nih, rheumatologic-diseases
Organization: U.S. Department of Health & Human Services
Compound 525392: 2,6-Dimethyl-3-thiaheptane

Chemical compound data from PubChem database. IUPAC Name: 3-methyl-1-propan-2-ylsulfanylbutane. Molecular Formula: C8H18S. Molecular Weight: 146.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Fusion of the

Background
          The NUP98 gene is involved in multiple rearrangements in haematological malignancy. The leukemic cells in an acute myeloid leukemia (AML) patient with a t(9;11)(p22;p15) were recently shown to have a fusion between the NUP98 gene and the LEDGF gene but it was not demonstrated that this fusion was recurrent in other leukaemia patients with the same translocation.
        
        
          Results
          We used RT-PCR to analyse the leukemic cells from an AML patient who presented with a cytogenetically identical translocation as the sole chromosomal abnormality. A NUP98-LEDGF fusion transcript was observed and confirmed by sequencing. The reciprocal transcript was also observed. The fusion transcript was not detectable during remission and recurred at relapse. The breakpoints in the NUP98 and LEDGF genes were different to those previously reported. The NUP98 breakpoint occurs in the intron between exons 8 and 9. It is the most 5' breakpoint reported in a translocation involving the NUP98 gene. All of the LEDGF gene is included in the fusion except for exon 1 which codes for the first 24 amino terminal amino acids.
        
        
          Conclusions
          Our results show that fusion of the NUP98 and LEDGF genes is a new recurrent translocation in AML.

Tags: aml-fusion, gene-rearrangement, hematological-malignancy, nih, nup98-ledgf
Organization: U.S. Department of Health & Human Services
Compound 528550: Naphthalene, decahydro-, 2,2'-bis

Chemical compound data from PubChem database. IUPAC Name: 2-(1,2,3,4,4a,5,6,7,8,8a-decahydronaphthalen-2-yl)-1,2,3,4,4a,5,6,7,8,8a-decahydronaphthalene. Molecular Formula: C20H34. Molecular Weight: 274.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Kinesin-like protein CENP-E is upregulated in rheumatoid synovial fibroblasts

Our aim was to identify specifically expressed genes using RNA arbitrarily primed (RAP)-polymerase chain reaction (PCR) for differential display in patients with rheumatoid arthritis (RA). In RA, amplification of a distinct PCR product suitable for sequencing could be observed. Sequence analysis identified the PCR product as highly homologous to a 434 base pair segment of the human centromere kinesin-like protein CENP-E. Differential expression of CENP-E was confirmed by quantitative reverse transcription PCR, immunohistochemistry and in situ hybridization. CENP-E expression was independent from prednisolone and could not be completely inhibited by serum starvation. RAP-PCR is a suitable method to identify differentially expressed genes in rheumatoid synovial fibroblasts. Also, because motifs of CENP-E show homologies to jun and fos oncogene products and are involved in virus assembly, CENP-E may be involved in the pathophysiology of RA.

Tags: cenp-e-protein, gene-expression, nih, rheumatoid-arthritis, synovial-fibroblasts
Organization: U.S. Department of Health & Human Services
Instructions to update the URS Table 1: Number of Persons with Serious Mental Illness, age 18 and older, by State, 2013 SAMHSA SMI and SED Estimates

These instructions explain how to update the 2013 Substance Abuse and Mental Health Services Administration (SAMHSA) Serious Mental Illness (SMI) and Serious Emotional Disturbances (SED) estimates. This includes obtaining the latest population data by state from the U.S. Census Bureau as well as the calculations and methodology necessary to create updated estimates.

Tags: population-estimates, samhsa, serious-mental-illness, smi-estimates, state-level-data
Organization: U.S. Department of Health & Human Services
Low systemic vascular resistance: differential diagnosis and
		  outcome

Objective:
          To determine the frequency and prognosis of the various causes of
				low systemic vascular resistance (SVR).
        
        
          Design:
          Analysis of consecutive patients over a 5-year period;
				retrospective review.
        
        
          Setting:
          Medical intensive care unit of a large university hospital.
        
        
          Patients:
          Fifty-five patients with unexplained hypotension and a SVR less
				than 800 dynes × s/cm5.
        
        
          Background:
          There are minimal data in the medical literature determining the
				frequency or outcome of patients with a low SVR that is unrelated to sepsis or
				the sepsis syndrome. We retrospectively reviewed and analyzed all hemodynamic
				data in a large university hospital over a 5-year period to determine the
				frequency and prognosis of the various causes of low SVR. Fifty-five patients
				with unexplained hypotension and a SVR less than
				800dynes×s/cm5were identified.
        
        
          Main results:
          Twenty-two patients (Groups 1 and 2) met the criteria for sepsis
				syndrome. The mean SVR for this group was 445 ±
				168 dynes×s/cm5 with an associated mortality of 50%. Group 3
				contained 20 patients with possible sepsis. Thirteen patients (Group 4) were
				nonseptic. The mean SVR of this group was 435 ±
				180 dynes × s/cm5 with an associated mortality of 46%. Extremely
				low SVR (below 450 dynes × s/cm5) was associated with a
				significantly higher mortality regardless of the etiology.
        
        
          Conclusions:
          At least a quarter of patients with hypotension and a low SVR have
				nonseptic etiologies. The patients with nonseptic etiologies have a similar
				mortality to septic patients. Clinicians should be aware of the wide spectrum
				of conditions that induce a low SVR.

Tags: hemodynamic-data, hypotension-icu, nih, systemic-vascular-resistance, vasodilation-etiology
Organization: U.S. Department of Health & Human Services