AndreaBozzo/ceres-open-data-index huggingface dataset:
Continuous haemofiltration in the intensive care unit

Continuous renal replacement therapy (CRRT) was first described in 1977 for the treatment of diuretic-unresponsive fluid overload in the intensive care unit (ICU). Since that time this treatment has undergone a remarkable technical and conceptual evolution. It is now available in most tertiary ICUs around the world and has almost completely replaced intermittent haemodialysis (IHD) in some countries. Specially made machines are now available, and venovenous therapies that use blood pumps have replaced simpler techniques. Although, it remains controversial whether CRRT decreases mortality when compared with IHD, much evidence suggests that it is physiologically superior. The use of CRRT has also spurred renewed interest in the broader concept of blood purification, particularly in septic states. Experimental evidence suggests that this is a promising approach to the management of septic shock in critically ill patients. The evolution and use of CRRT is likely to continue and grow over the next decade.

Tags: continuous-haemofiltration, icu-patients, nih, renal-replacement-therapy, septic-shock
Organization: U.S. Department of Health & Human Services
Angiotensin receptor blockers in heart failure after the ELITE II trial

Specific blockers of the angiotensin type1 receptor, angiotensin receptor blockers (ARBs), have been introduced as an alternative to angiotensin-converting enzyme inhibitors (ACEi) for the treatment of heart failure. In comparison with ACEi, ARBs are better tolerated and have similar effects on haemodynamics, neurohormones and exercise capacity. Early studies have suggested that ARBs might have a superior effect on mortality. However, the first outcome trial, ELITE II (Losartan Heart Failure Survival Study), did not show any significant difference between losartan and captopril in terms of mortality or morbidity. This commentary outlines the role of ARBs in the treatment of heart failure.

Tags: angiotensin-receptor-blockers, elite-ii-trial, heart-failure, losartan-captopril, nih
Organization: U.S. Department of Health & Human Services
2014 CMHS Uniform Reporting System (URS) Table for Republic of Marshall Islands

2014 Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for the Republic of Marshall Islands. The URS associated state reporting system is collected annually to support the Community Mental Health Services Block Grant program. Associated state Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: marshall-islands, mental-health-services, national-outcome-measures, samhsa, urs-data
Organization: U.S. Department of Health & Human Services
High copy arrays containing a sequence upstream of

Background
          The Caenorhabditis elegans gene mec-3 encodes a LIM-homeodomain protein that is a master regulator of touch receptor neuron genes. Two of the touch neurons, the ALM neurons, are generated in the anterior of the animal and then migrate to near the middle of the animal. In animals transformed with a sequence upstream of mec-3, the ALM touch receptor neurons failed to migrate to their normal positions and sometimes migrated in the wrong direction, and the PLM touch receptor neurons showed axonal defects. Here we characterize this effect and identify the sequence causing the cell migration and axonal defects.
        
        
          Results
          The ALM migration defect did not result from RNA interference (RNAi), nonspecific effects of carrying a transgenic array, expression of GFP, or the marker gene used to make the transformants. Instead, the ALM migration defect resulted from transgenic arrays containing many copies of a specific 104 bp DNA sequence. Transgenic arrays containing this sequence did not affect all cell migrations.
        
        
          Conclusions
          The mec-3 upstream sequence appeared to be sequestering (titrating out) a specific DNA-binding factor that is required for the ALMs to migrate correctly. Because titration of this factor could reverse the direction of ALM migrations, it may be part of a program that specifies both the direction and extent of ALM migrations. mec-3 is a master regulator of touch receptor neuron genes, so the factor or factors that bind this sequence may also be involved in specifying the fate of touch receptor neurons.

Tags: c-elegans, mec-3-gene, neuron-migration, nih, touch-receptor-neurons
Organization: U.S. Department of Health & Human Services
Compound 528515: Hexadecane, 4-octyl

Chemical compound data from PubChem database. IUPAC Name: 9-propylhenicosane. Molecular Formula: C24H50. Molecular Weight: 338.7. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2021 Uniform Reporting System (URS) Table For New Jersey

This is the 2021 Uniform Reporting System (URS) Output Tables for New Jersey. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-program, evidence-based-practices, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
2012 State Profile - Federation of Micronesia

This is a National Survey of Substance Abuse Treatment Services (N-SSATS) annual report showing the state profile for Federation of Micronesia in 2012. N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 States, the District of Columbia, and other U.S. jurisdictions.

Tags: alcohol-drug-services, micronesia, n-ssats, samhsa, substance-abuse-treatment
Organization: U.S. Department of Health & Human Services
Publications Using SAMHSA DataSupplemental NSDUH Opioid Tables

These tables are special analyses that include opioid use (or heroin use and prescription pain reliever misuse) or opioid use disorders as a variable.  The NSDUH survey years used, as well as by-demographic group analyses, vary.

Tags: nsduh-survey, opioid-use, prescription-pain-reliever, samhsa, substance-use-disorder
Organization: U.S. Department of Health & Human Services
Interactive decision support in hepatic surgery

Background
          Hepatic surgery is characterized by complicated operations with a significant peri- and postoperative risk for the patient. We developed a web-based, high-granular research database for comprehensive documentation of all relevant variables to evaluate new surgical techniques.
        
        
          Methods
          To integrate this research system into the clinical setting, we designed an interactive decision support component. The objective is to provide relevant information for the surgeon and the patient to assess preoperatively the risk of a specific surgical procedure.
          Based on five established predictors of patient outcomes, the risk assessment tool searches for similar cases in the database and aggregates the information to estimate the risk for an individual patient.
        
        
          Results
          The physician can verify the analysis and exclude manually non-matching cases according to his expertise. The analysis is visualized by means of a Kaplan-Meier plot.
          To evaluate the decision support component we analyzed data on 165 patients diagnosed with hepatocellular carcinoma (period 1996–2000). The similarity search provides a two-peak distribution indicating there are groups of similar patients and singular cases which are quite different to the average. The results of the risk estimation are consistent with the observed survival data, but must be interpreted with caution because of the limited number of matching reference cases.
        
        
          Conclusion
          Critical issues for the decision support system are clinical integration, a transparent and reliable knowledge base and user feedback.

Tags: decision-support-tool, hepatic-surgery, liver-resection, nih, surgical-risk-assessment
Organization: U.S. Department of Health & Human Services
Table 3. Marijuana Use in the Past Month, by Age Group and State: Percentages, Annual Averages Based on 2010 and 2011 NSDUHs

This report presents State estimates for measures of past month marijuana use based on the combined 2010 and 2011 National Surveys on Drug Use and Health (NSDUHs). Resuts are provided by age group.

Tags: marijuana-use, nsduh-data, samhsa, state-level-data, substance-use
Organization: U.S. Department of Health & Human Services
Role of bedside electroencephalography in the adult intensive care unit during therapeutic neuromuscular blockade

Background:
          Size, weight and technical difficulties limit the use of ponderous strip chart electroencephalographs (EEGs) for real time evaluation of brain wave function in modern intensive care units (ICUs). Portable, computer processed, bedside EEGs provide real time brain wave appraisal for some brain functions during therapeutic neuromuscular blockade when the visual clues of the cerebral function disappear.
        
        
          Results:
          Critically ill ICU patients are frequently placed in suspended animation by neuromuscular blockade to improve hemodynamics in severe organ system failure. Using the portable bedside EEG monitor, several cerebral functions were monitored continuously during sedation of selected patients in our ICU.
        
        
          Conclusions:
          The processed EEG is able to continuously monitor the end result of some therapeutics at the neuronal level when natural artifacts are suppressed or eliminated by neuromuscular blockade. Computer processed EEG monitoring may be the only objective method of assessing and controlling sedation during therapeutic musculoskeletal paralysis.

Tags: brain-function, eeg-monitoring, icu-patients, neuromuscular-blockade, nih
Organization: U.S. Department of Health & Human Services
Cholinergic and GABAergic pathways in fly motion vision

Background
          The fly visual system is a highly ordered brain structure with well-established physiological and behavioral functions. A large number of interneurons in the posterior part of the third visual neuropil, the lobula plate tangential cells (LPTCs), respond to visual motion stimuli. In these cells the mechanism of motion detection has been studied in great detail. Nevertheless, the cellular computations leading to their directionally selective responses are not yet fully understood. Earlier studies addressed the neuropharmacological basis of the motion response in lobula plate interneurons. In the present study we investigated the distribution of the respective neurotransmitter receptors in the fly visual system, namely nicotinic acetylcholine receptors (nAChRs) and GABA receptors (GABARs) demonstrated by antibody labeling.
        
        
          Results
          The medulla shows a laminar distribution of both nAChRs and GABARs. Both receptor types are present in layers that participate in motion processing. The lobula also shows a characteristic layering of immunoreactivity for either receptor in its posterior portion. Furthermore, immunostaining for nAChRs and GABARs can be observed in close vicinity of lobula plate tangential cells. Immunostaining of GABAergic fibers suggests that inhibitory inputs from the medulla are relayed through the lobula to the lobula plate rather than through direct connections between medulla and lobula plate.
        
        
          Conclusions
          The interaction of excitatory and inhibitory pathways is essential for the computation of visual motion responses and discussed in the context of the Reichardt model for motion detection.

Tags: cholinergic-pathways, fly-visual-system, gabaergic-pathways, motion-vision, nih
Organization: U.S. Department of Health & Human Services
2014 CMHS Uniform Reporting System (URS) Table for Pennsylvania

2014 Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for Pennsylvania. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: behavioral-health, mental-health-services, national-outcome-measures, samhsa, urs-data
Organization: U.S. Department of Health & Human Services
Adult Mental Health Tables (Standard Errors and P values) - 1.1 to 1.64

These are the detailed tables pertaining to adult mental health from the 2010 National Survey on Drug Use and Health (NSDUH). These detailed tables present standard errors for totals and prevalence estimates of past year any mental illness (AMI), serious mental illness (SMI), suicidal thoughts and behavior, major depressive episode (MDE), treatment for depression (among adults with MDE), mental health service utilization, and measuers related to the co-occurrence of mental disorders with substance use or with substance use disorders. Results are provided for age group, gender, race/ethnicity, education level, employment status, poverty level, geographic area, insurance status. Comparisons are made between 2010 and 2002 to 2009.

Tags: adult-mental-health, mental-illness-prevalence, nsduh-2010, samhsa, suicidal-ideation
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Region 7, Volume 6

This is a behavioral health report for HHS Region VII of the United States and utilizes data from the National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment (N-SSATS), collected annually. The topics addressed in the reports include youth mental health and treatment, substance use and substance use treatment.

Tags: behavioral-health, mental-health, samhsa, substance-use, youth-mental-health
Organization: U.S. Department of Health & Human Services
TEDS Substance Abuse Treatment Admissions by Primary Substance of Abuse, According to Sex, Age Group, Race, and Ethnicity Tables 2014

This a Treatment Episode Data Set (TEDS) data table displaying substance abuse treatment admissions by primary substance abuse, according to sex, age group, race, and ethnicity. The Treatment Episode Data Set (TEDS) is a national data system of annual admissions to substance abuse treatment facilities. TEDS received treatment admission records from 46 states, the District of Columbia, and Puerto Rico in 2014.

Tags: primary-substance, samhsa, substance-abuse-treatment, teds-admissions, treatment-episode-data
Organization: U.S. Department of Health & Human Services
Debate: PCI vs CABG: a moving target, but we are gaining

The treatment of patients with coronary artery disease continues to evolve; all three strategies – medical therapy, surgical revascularization, and percutaneous coronary intervention – have changed. Medical therapy with intense risk-factor modification and treatment with a statin, aspirin, and angiotensin-converting enzyme (ACE) inhibitors, should be used unless contraindicated. Surgical therapy has also changed with the introduction of minimally invasive, beating heart surgery. Percutaneous coronary intervention has perhaps changed the most radically with adjunctive therapy – glycoprotein IIb/IIIa inhibitors, thienopyridines, and reliance on stent implantation. The future, with new distal protection devices and drug-coated stents, should continue to see increased numbers of patients who can benefit from percutaneous intervention.

Tags: coronary-artery-disease, nih, pci-cabg, revascularization, stent-implantation
Organization: U.S. Department of Health & Human Services
2016-2017 NSDUH State Estimates Categorized into Five Groups by Age Group

States Categorized into Five Groups from Lowest to Highest Estimate, by Age Group: Percentages, Annual Averages Based on 2016 and 2017 NSDUHs

Tags: age-groups, mental-health, samhsa, state-level-data, substance-use
Organization: U.S. Department of Health & Human Services
2023 Uniform Reporting System (URS) Table For Texas

This is the 2023 Uniform Reporting System (URS) Output Tables for Texas. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-program, mental-health-services, national-outcome-measures, samhsa, texas
Organization: U.S. Department of Health & Human Services
2019 Uniform Reporting System (URS) Table for Oklahoma

These are the 2019 Uniform Reporting System (URS) Output Tables for Oklahoma. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-data, mental-health-services, national-outcome-measures, oklahoma, samhsa
Organization: U.S. Department of Health & Human Services
Tennessee (TN)

This report uses 2008 to 2010 National Survey on Drug Use and Health (NSDUH) to assess past year alcohol use disorder and illicit drug use disorder among persons aged 12 or older for Tennessee overall and for substate regions within Tennessee. Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE).

Tags: alcohol-abuse, mental-health-tn, nsduh-data, samhsa, substance-use-disorder
Organization: U.S. Department of Health & Human Services
Comparison of complete nuclear receptor sets from the human,

Background
          The availability of complete genome sequences enables all the members of a gene family to be identified without limitations imposed by temporal, spatial or quantitative aspects of mRNA expression. Using the nearly completed human genome sequence, we combined in silico and experimental approaches to define the complete human nuclear receptor (NR) set. This information was used to carry out a comparative genomic study of the NR superfamily.
        
        
          Results
          Our analysis of the human genome identified two novel NR sequences. Both these contained stop codons within the coding regions, indicating that both are pseudogenes. One (HNF4 γ-related) contained no introns and expressed no detectable mRNA, whereas the other (FXR-related) produced mRNA at relatively high levels in testis. If translated, the latter is predicted to encode a short, non-functional protein. Our analysis indicates that there are fewer than 50 functional human NRs, dramatically fewer than in Caenorhabditis elegans and about twice as many as in Drosophila. Using the complete human NR set we made comparisons with the NR sets of C. elegans and Drosophila. Searches for the >200 NRs unique to C. elegans revealed no human homologs. The comparative analysis also revealed a Drosophila member of NR subfamily NR3, confirming an ancient metazoan origin for this subfamily.
        
        
          Conclusions
          This work provides the basis for new insights into the evolution and functional relationships of NR superfamily members.

Tags: gene-family, genome-sequence, nih, nuclear-receptors, pseudogenes
Organization: U.S. Department of Health & Human Services
Debate: Should the elderly receive thrombolytic therapy or primary angioplasty?

Thrombolysis and primary angioplasty are both recommended reperfusion strategies for elderly patients presenting with myocardial infarction (MI). Primary angioplasty is most beneficial in high-risk patients. While the elderly have a high absolute risk of dying or developing complications after MI, they also have an increased risk of intracranial haemorrhage if they are given thrombolytic therapy. It could therefore be reasonably argued that primary angioplasty is the reperfusion strategy of choice in the elderly. However, primary angioplasty has not been shown to have a greater relative benefit than thrombolytic therapy in the elderly. Recent data from the Fibrinolytic Therapy Trialists' (FTT) Collaborative Group show that thrombolytic therapy significantly reduces mortality compared with control treatment in patients over 75 years of age presenting within 12 h of symptom onset, with ST-segment elevation or bundle branch block. Future advances in adjunctive therapies may improve myocyte perfusion and hence the outcomes achieved by both invasive and noninvasive reperfusion strategies. Better thrombolytic regimens incorporating adjunctive agents such as bivalirudin may reduce the risk of intracranial haemorrhage. Few hospitals can provide a 24-h primary angioplasty service with door-to-balloon times consistently less than 90 min, and thrombolytic therapy is therefore a far more practical option in most instances.

Tags: elderly-patients, myocardial-infarction, nih, primary-angioplasty, thrombolytic-therapy
Organization: U.S. Department of Health & Human Services
New York City - 5 Boros

Data tables consisting of Excel files with estimates, rates, relative standard errors, trends and confidence intervals, covering 2004-2011, for drug-related emergency department visits in New York City (5 boroughs). Tables are provided for 10 topics (\"analytic categories\") which are defined in the \"Guide to Drug Abuse Warning Trend Tables,\" a separate document.   Each table includes data for over 500 drugs, including illicit drugs, prescription and over-the-counter medications, dietary supplements, inhalants and alcohol. Includes total visits, gender, age group, race/ethnicity, outcome of visit, drug combinations, number of drugs involved in visit, drug frequency, and drugs confirmed by toxicology. Additional detail is provided for illicit drugs, psychotherapeutic drugs, central nervous system (CNS) drugs, respiratory drugs and cardiovascular drugs.

Tags: drug-related-ed-visits, emergency-department-data, samhsa, substance-abuse-trends, toxicology-confirmed-drugs
Organization: U.S. Department of Health & Human Services