AndreaBozzo/ceres-open-data-index huggingface dataset:
Table 21. Dependence or Abuse of Illicit Drugs or Alcohol in the Past Year among Persons Aged 12 or Older, by State and Substate Regions: Percentages, Annual Averages Based on 2008, 2009, and 2010 NSDUHs

This table presents the 2008 to 2010 National Survey on Drug Use and Health (NSDUH) estimates of past year alcohol or illicit drug dependence or abuse by those aged 12 or older by State and substate regions.

Tags: alcohol-abuse, drug-dependence, nsduh-data, samhsa, substance-use-disorder
Organization: U.S. Department of Health & Human Services
Texas: 2011-2012 NSDUH

This report presents Texas\'s estimates for 25 measures of substance use and mental health based on the combined 2011 and 2012 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided by State and for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: mental-health, samhsa, serious-mental-illness, substance-use, texas-nsduh
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Rhode Island, 2015

This is a behavioral health report for the state of Rhode Island. The report utilizes data from the National Survey on Drug Use and Health (NSDUH), and the Uniform Reporting System. The topics addressed in the report include youth substance use, youth mental health and treatment, mental health and treatment, substance use and substance use treatment.

Tags: behavioral-health, mental-health, rhode-island, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
2016 Uniform Reporting System (URS) Table for Mississippi

This is the 2016 Uniform Reporting System (URS) Output Tables for Mississippi. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: mental-health-services, mississippi, national-outcome-measures, samhsa, substance-abuse-treatment
Organization: U.S. Department of Health & Human Services
If Data Standards Follow Maslow’s Hierarchy of Needs, Are We Ready for Safety?

In the 1940s, renowned psychologist Abraham Maslow first published his work on human motivation. Maslow believed that human beings were motivated to fulfill certain needs. Further, he hypothesized that it was only when basic needs were met that individuals could move on to achieve higher-level goals. It is useful to think of data system needs according to a similar hierarchy—by meeting basic functioning requirements before systems can reasonably be expected to perform more advanced functions.

This webinar will examine the experience of Maryland’s child welfare agencies and the data standards challenges they face, from counting child protective services and in-home cases, to counting children in out-of-home care, and to assuring that their Statewide Automated Child Welfare Information System is meeting minimum data standards for Federal reporting (i.e., the National Child Abuse and Neglect Data System, the Adoption and Foster Care Analysis and Reporting System, caseworker visitation, and the National Youth in Transition Database). But among all of Maryland's challenges, none have been more daunting than client identification and establishing basic interagency interfaces.

We will present stories of frustration from Maryland child welfare agencies about the problems related to these very basic data standards. While resolutions to these problems have been elusive for Maryland, the webinar will describe how—through the implementation of IT modernization efforts—the State hopes to address these vexing challenges.

The speakers for this webinar will be David Ayer, director, Research, Evaluation and Systems Development, Maryland Department of Health and Human Services, as well as members of his team.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: child, data, policy, reporting, standard
Organization: U.S. Department of Health & Human Services
Comments on ALLHAT and doxazosin

This commentary has two purposes: to summarize the rationale, design and initial results of the Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) trial; and to provide a history of the response to ALLHAT that led to a civil action and a Citizens Petition that was the basis for a public hearing by the US Food and Drug Administration, in May 2001. The author concludes that the results of ALLHAT should be widely disseminated. All clinicians must be warned that initial therapy with doxazosin (and possibly other alpha1 blockers) is definitely inferior to low dose diuretic treatment for patients at high risk for cardiovascular disease, such as those enrolled in ALLHAT.

Tags: allhat-trial, cardiovascular-disease, doxazosin-therapy, hypertension-treatment, nih
Organization: U.S. Department of Health & Human Services
2021-2022 NSDUH National Maps of Prevalence Estimates, by State

View national maps covering 35 measures of substance use and mental health by age group and state. The maps are based on the 2021-2022 National Surveys on Drug Use and Health (NSDUH). They use small area estimation (SAE) methods in which state-level NSDUH data are combined with other data from smaller geographies. The combined data are used to create modeled estimates of the civilian, noninstitutionalized population ages 12 and older for each state.The map images are available as a PDF or HTM file.

Tags: mental-health, samhsa, small-area-estimation, state-prevalence, substance-use
Organization: U.S. Department of Health & Human Services
West Virginia 2016 Potential Areas for Addressing Service Gaps for Opioid Treatment

The purpose of the medication-assisted treatment (MAT) facility maps is to identify areas on a state-by-state basis that may be potentially underserved by existing treatment facilities. The maps are created with a methodology that seeks to include the highest potential need areas from individual counties so that county-level stakeholders are also informed. The maps are meant to be used as a tool for policy makers to determine potentially underserved areas—not as a definitive representation of these areas.

Tags: mat-access, opioid-treatment, samhsa, service-gap-analysis, west-virginia
Organization: U.S. Department of Health & Human Services
Compound 525617: N,N-Dimethyl-N'-butyl-p-methylbenzamidine

Chemical compound data from PubChem database. IUPAC Name: N'-butyl-N,N,4-trimethylbenzenecarboximidamide. Molecular Formula: C14H22N2. Molecular Weight: 218.34. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Research Article: BMC Pharmacology

Background
          Leishmaniasis is a common parasitic disease in Southern Europe, caused by Leishmania infantum. The failures of current treatment with pentavalent antimonials are partially attributable to the emergence of antimony-resistant Leishmania strains. This study analyses the in vitro susceptibility to pentavalent antimony of intracellular amastigotes from a range of L. infantum strains, derived from the same infected animal, during in vitro and in vivo passages and after host treatment with meglumine antimoniate.
        
        
          Results
          SbV-IC50 values for strains from two distinct isolates from the same host and one stock after two years of culture in NNN medium and posterior passage to hamster were similar (5.0 ± 0.2; 4.9 ± 0.2 and 4.4 ± 0.1 mgSbV/L, respectively). In contrast, a significant difference (P < 0.01, t test) was observed between the mean SbV-IC50 values in the stocks obtained before and after treatment of hosts with meglumine antimoniate (4.7 ± 0.4 mgSbV/L vs. 7.7 ± 1.5 mgSbV/L). Drug-resistance after drug pressure in experimentally infected dogs increased over repeated drug administration (6.4 ± 0.5 mgSbV/L after first treatment vs. 8.6 ± 1.4 mgSbV/L after the second) (P < 0.01, t test).
        
        
          Conclusions
          These results confirm previous observations on strains from Leishmania/HIV co-infected patients and indicate the effect of the increasing use of antimony derivatives for treatment of canine leishmaniasis in endemic areas on the emergence of Leishmania antimony-resistant strains.

Tags: antimony-resistance, in-vitro-susceptibility, leishmania-infantum, meglumine-antimoniate, nih
Organization: U.S. Department of Health & Human Services
North Carolina (NC)

This report presents North Carolina\'s estimates for 25 measures of substance use and mental health based on the combined 2009 and 2010 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for North Carolina for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: mental-health, north-carolina, nsduh-data, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Publications Using SAMHSA DataBehavioral Health Equity Barometer

The Behavioral Health Equity Barometer, United States, 2014 provides a snapshot of substance use and mental health indicators by selected determinants of health: race and ethnicity, income level, geographic location, and health insurance status in the United States as measured through the National Survey on Drug Use and Health (NSDUH) data collection efforts sponsored by SAMHSA. The topics addressed in this report include youth substance use, youth mental health and treatment, adult mental health and treatment, substance abuse and substance abuse treatment for the years 2009 to 2013.

Tags: behavioral-health-equity, health-disparities, mental-health-indicators, samhsa, substance-use-disorders
Organization: U.S. Department of Health & Human Services
Mini-laparoscopic versus laparoscopic approach to appendectomy

Background
          The purpose of this clinical study is to evaluate the feasibility of using 2-mm laparoscopic instruments to perform an appendectomy in patients with clinically suspected acute appendicitis and compare the outcome of this mini-laparoscopic or "needlescopic" approach to the conventional laparoscopic appendectomy.
        
        
          Methods
          Two groups of patients undergoing appendectomy over 24 months were studied. In the first group, needlescopic appendectomy was performed in 15 patients by surgeons specializing in advanced laparoscopy. These patients were compared with the second or control group that included 21 consecutive patients who underwent laparoscopic appendectomy. We compared the patients' demographic data, operative findings, complications, postoperative pain medicine requirements, length of hospital stay, and recovery variables. Differences were considered statistically significant at a p-value < 0.05.
        
        
          Results
          Patient demographics, history of previous abdominal surgery, and operative findings were similar in both groups. There was no conversion to open appendectomy in either group. No postoperative morbidity or mortality occurred in either group. The needlescopic group had a significantly shorter mean operative time (p = 0.02), reduced postoperative narcotics requirements (p = 0.05), shorter hospital stay (p = 0.04), and quicker return to work (p = 0.03) when compared with the laparoscopic group.
        
        
          Conclusions
          We conclude that the needlescopic technique is a safe and effective approach to appendectomy. When performed by experienced laparoscopic surgeons, the needlescopic technique results in significantly shorter postoperative convalescence and a prompt recovery.

Tags: acute-appendicitis, appendectomy, laparoscopic-surgery, nih, surgical-outcomes
Organization: U.S. Department of Health & Human Services
Half of Substance Abuse Treatment Admissions among Veterans Aged 21 to 39 Involve Alcohol as the Primary Substance of Abuse

This Data Spotlight from the Treatment Episode Data Set (TEDS) focuses on substances of abuse among military personnel and veterans aged 21 to 39 who were admitted to substance abuse treatment during 2010.

Tags: alcohol-abuse-treatment, samhsa, teds-data, veteran-substance-abuse, young-adult-veterans
Organization: U.S. Department of Health & Human Services
National Directory of Mental Health Treatment Facilities 2012

The National Directory of Mental Health Treatment Facilities for 2012 lists federal facilities (U.S. Department of Veterans Affairs medical centers), state and local government (public) facilities, and private (for profit and nonprofit) facilities that responded to the 2010 National Mental Health Services Survey (N-MHSS), a national survey the Substance Abuse and Mental Health Services Administration (SAMHSA) conducts biennially. The facilities were eligible if they indicated a primary focus of providing mental health treatment services. The information about each facility that appears in this directory was provided by that facility in response to the 2010 N-MHSS. The directory is ordered alphabetically by state, by city within each state, and by facility name within each city.

Tags: facility-survey, mental-health-facilities, mental-health-services, samhsa, treatment-directory
Organization: U.S. Department of Health & Human Services
Antenatal infection/inflammation and postnatal lung maturation and injury

Chorioamnionitis is frequently associated with preterm deliveries before 30 weeks gestation. Chorioamnionitis correlates both with an increased risk of bronchopulmonary dysplasia and with a decreased risk of respiratory distress syndrome. Both interleukin-1α and endotoxin can induce inflammation in the fetal lungs and lung maturation after preterm birth when given by intra-amniotic injection. Inflammation can also result in an arrest of alveolarization, and this lung developmental abnormality is prominent in the lungs of preterm infants that die of bronchopulmonary dysplasia. The mechanisms by which infection/inflammation can have both beneficial and injurious effects on the preterm lung remain to be characterized.

Tags: bronchopulmonary-dysplasia, chorioamnionitis, nih, preterm-lung, respiratory-distress
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: South Carolina, 2013

This is a behavioral health report for the state of South Carolina. It uses the  National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment Services (NSSATS) to address the topics of youth substance use , youth mental health and treatment, adult mental health and treatment, substance use, substance use treatment for the years 2008 to 2012.

Tags: behavioral-health, mental-health, samhsa, south-carolina, substance-use
Organization: U.S. Department of Health & Human Services
The evaluation of yeast derivatives as adjuvants for the immune response to the Bm86 antigen in cattle

Background
          The Gavac™ vaccine against the cattle tick Boophilus microplus has proven its efficacy in a large number of controlled and field experiments. However, this vaccine could be further improved by searching for new alternative adjuvants that would induce a stronger long-lasting immune response. We conducted several experiments to assay the adjuvant effect of fractions of the recombinant yeast Pichia pastoris in mouse and cattle models. In previous experiments, the combination of the yeast membrane with saponin was the most effective formulation in stimulating the humoral immune response in mice, eliciting a response higher than Montanide 888. The response was predominantly of the IgG1 isotype. Here, we evaluated the response in cattle and compared the results with that obtained in mice.
        
        
          Results
          Bm86 on the membrane of P. pastoris plus saponin produced high antibody titers in cattle, though the protection level against tick infestations was lower when compared to Gavac™, probably due to a decrease in the IgG1/IgG2 ratio. The predictive value of the mouse model was studied through correlation analysis between the isotype levels in mice and the efficacy of formulations in cattle. Good correlation was established between the level of antibodies in mice and cattle, and between the amount of anti -Bm86 IgG1 in mice and the degree of protection in cattle.
        
        
          Conclusion
          Mouse model have the potential to predict immunogenicity and efficacy of formulations in cattle. These results also support the use of the yeast expression system for recombinant vaccine formulations, enabling the prediction of more cost - effective formulations.

Tags: boophilus-microplus, cattle-vaccination, nih, tick-infestation, yeast-adjuvant
Organization: U.S. Department of Health & Human Services
New York (NY)

This report presents estimates for measures of substance use and mental health based on the combined 2010 and 2011 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for New York for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: mental-health, ny-survey, samhsa, substance-use, suicidal-ideation
Organization: U.S. Department of Health & Human Services
Compound 528462: 1-Tetradecene, 4,8,12-trimethyl

Chemical compound data from PubChem database. IUPAC Name: 4,8,12-trimethyltetradec-1-ene. Molecular Formula: C17H34. Molecular Weight: 238.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Fibroblast biology: Synovial fibroblasts in rheumatoid arthritis - leading role or chorus line?

Fibroblast biology: Synovial fibroblasts in rheumatoid arthritis - leading role or chorus line?

Tags: arthritis-research, fibroblast-biology, nih, rheumatoid-arthritis, synovial-fibroblasts
Organization: U.S. Department of Health & Human Services
2011 Uniform Reporting System (URS) Output Tables for Guam

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2011. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, guam-mental-health, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Polyomyositis and myocarditis associated with acquired toxoplasmosis in an immunocompetent girl

Background
          Acquired toxoplasmosis more frequently goes unrecognized. Immunocompetent adults and adolescents with primary infection are generally asymptomatic, but symptoms may include malaise, fever, and lymphadenopathy. By contrast, immunocompromised patients may experience severe manifestations including encephalitis and multisystem organ failure.
        
        
          Case presentation
          We report a case of polymyositis and myocarditis in a 13-year old immunocompetent girl with toxoplasmosis. The patient presented with proximal muscle weakness, dysphagia, palms and soles rash and elevated serum levels of muscle enzymes, with liver and myocardial involvement. The diagnosis of toxoplasmosis was confirmed by serology. The patient was treated with prednisolone and had an excellent outcome. During a follow-up period of four years no relapses occurred and antibody levels to the T. gondii significantly decreased.
        
        
          Conclusions
          Although several previous cases of toxoplasmosis occuring in association with polymyositis have been described in the literature such a wide spectrum of acute toxoplasmosis is rather unusual in immunocompetent adolescents. The relationship between T. gondii and polymyositis remains obscure. Appropriate investigation should be performed in every case of polymyositis not only for the appropriate treatment but also for further elucidation of this relationship.

Tags: myocarditis, nih, pediatric-health, polymyositis, toxoplasmosis
Organization: U.S. Department of Health & Human Services
Lack of agreement between bioimpedance and continuous thermodilution measurement of cardiac output in intensive care unit patients

Background:
          Bolus thermodilution is the standard bedside method of cardiac output measurement in the intensive care unit (ICU). The Baxter Vigilance monitor uses a modified thermodilution pulmonary artery catheter with a thermal filament to give a continuous read-out of cardiac output. This has been shown to correlate very well with both the 'gold standard' dye dilution method and the bolus thermodilution method. Bioimpedance cardiography using the Bomed NCCOM 3 offers a noninvasive means of continuous cardiac output measurement and has been shown to correlate with the bolus thermodilution method. We investigated the agreement between the continuous bioimpedance and continuous thermodilution methods, enabling acquisition of a large number of simultaneous measurements.
        
        
          Results:
          A total of 2390 paired data points from seven patients were collected. There was no correlation (r2 = 0.01) between the methods. The precision (1.16 l/min/m2) of agreement between the Vigilance and the Bomed, assessed by the Bland-Altam method, was very poor although the bias (-0.16 l/min/m2) appeared fair.
        
        
          Conclusions:
          The Bomed NCCOM 3 bioimpedance monitor shows poor agreement with the Baxter Vigilance continuous thermodilution monitor in a group of general ICU patients and cannot be recommended for cardiac output monitoring in this situation.

Tags: bioimpedance, cardiac-output, intensive-care, nih, thermodilution
Organization: U.S. Department of Health & Human Services