AndreaBozzo/ceres-open-data-index huggingface dataset:
Close relationship of tissue plasminogen activator-plasminogen 
activator inhibitor-1 complex with multiple organ dysfunction syndrome 
investigated by means of the artificial pancreas

Background:
          Glucose tolerance (GT) has not been taken into consideration in 
investigations concerning relationships between coagulopathy and multiple organ 
dysfunction syndrome (MODS), and endothelial cell activation/endothelial cell 
injury (ECA/ECI) in septic patients, although coagulopathy is known to be 
influenced by blood glucose level. We investigated those relationships under 
strict blood glucose control and evaluation of GT with the glucose clamp method 
by means of the artificial pancreas in nine septic patients with glucose 
intolerance. The relationships between GT and blood stress related hormone 
levels (SRH) were also investigated.
        
        
          Methods:
          The amount of metabolized glucose (M value), as the parameter of 
GT, was measured by the euglycemic hyperinsulinemic glucose clamp method, in 
which the blood glucose level was clamped at 80 mg/dl under a continuous 
insulin infusion rate of 1.12 mU/kg per min, using the artificial pancreas, 
STG-22. Multiple organ failure (MOF) score was calculated using the MOF 
criteria of Japanese Association for Critical Care Medicine. Regarding 
coagulopathy, the following parameters were used: disseminated intravascular 
coagulation (DIC) score (calculated from the DIC criteria of the Ministry of 
Health and Welfare of Japan) and the parameters used for calculating DIC score, 
protein-C, protein-S, plasminogen, antithrombin III (AT-III), plasminogen 
activator inhibitor-1 (PAI-1), and tissue plasminogen activator-PAI-1 
(tPA-PAI-1) complex. Thrombomodulin (TM) was measured as the indicator of 
ECI.
        
        
          Results:
          There were no significant correlations between M value and SRH, 
parameters indicating coagulopathy and the MOF score. The MOF score and blood 
TM levels were positively correlated with DIC score, thrombin-AT-III complex 
and tPA-PAI-1 complex, and negatively correlated with blood platelet count.
        
        
          Conclusions:
          GT was not significantly related to SRH, coagulopathy and MODS under strict 
blood glucose control. Hypercoagulability was closely related to MODS and ECI. 
Among the parameters indicating coagulopathy, tPA-PAI-1 complex, which is 
considered to originate from ECA, seemed to be a sensitive parameter of MODS 
and ECI, and might be a predictive marker of MODS. The treatment for reducing 
hypercoagulability and ECA/ECI were thought to be justified as one of the 
therapies for acutely ill septic patients.

Tags: glucose-tolerance, multiple-organ-dysfunction, nih, septic-patients, tissue-plasminogen-activator
Organization: U.S. Department of Health & Human Services
Retroviral transfer of the p16INK4a cDNA inhibits C6 glioma formation in Wistar rats

Background
          The p16INK4A gene product halts cell proliferation by preventing phosphorylation of the Rb protein. The p16INK4a gene is often deleted in human glioblastoma multiforme, contributing to unchecked Rb phosphorylation and rapid cell division. We show here that transduction of the human p16INK4a cDNA using the pCL retroviral system is an efficient means of stopping the proliferation of the rat-derrived glioma cell line, C6, both in tissue culture and in an animal model. C6 cells were transduced with pCL retrovirus encoding the p16INK4a, p53, or Rb genes. These cells were analyzed by a colony formation assay. Expression of p16INK4a was confirmed by immunohistochemistry and Western blot analysis. The altered morphology of the p16-expressing cells was further characterized by the senescence-associated β-galactosidase assay. C6 cells infected ex vivo were implanted by stereotaxic injection in order to assess tumor formation.
        
        
          Results
          The p16INK4a gene arrested C6 cells more efficiently than either p53 or Rb. Continued studies with the p16INK4a gene revealed that a large portion of infected cells expressed the p16INK4a protein and the morphology of these cells was altered. The enlarged, flat, and bi-polar shape indicated a senescence-like state, confirmed by the senescence-associated β-galactosidase assay. The animal model revealed that cells infected with the pCLp16 virus did not form tumors.
        
        
          Conclusion
          Our results show that retrovirus mediated transfer of p16INK4a halts glioma formation in a rat model. These results corroborate the idea that retrovirus-mediated transfer of the p16INK4a gene may be an effective means to arrest human glioma and glioblastoma.

Tags: c6-glioma-cells, glioma-formation, nih, p16ink4a-gene, retroviral-transfer
Organization: U.S. Department of Health & Human Services
Kansas Intensive Permanency Project (KIPP) Program Manual

This PII grantee program manual provides detailed information about the implementation process of the Kansas Intensive Permanency Project (KIPP) to assist others in the field in replicating or adapting KIPP for their local use. Readers will find reflections, lessons learned, and other practical information based on the experience of the KIPP project. The manual can be especially helpful if you are considering implementation of the intervention, interested in addressing the needs of similar target populations, or interested in lessons learned from real-world implementation experiences. Together, the PII program manuals help to build a base of replicable interventions that can serve the complex needs of diverse communities of children and families.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: grant, intervention, manual, permanency, policy
Organization: U.S. Department of Health & Human Services
Washington (WA)

This report presents estimates for measures of substance use and mental health based on the combined 2010 and 2011 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for Washington for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: mental-health, nsduh-survey, samhsa, substance-use, washington-state
Organization: U.S. Department of Health & Human Services
2017 Uniform Reporting System (URS) Table for Utah

This is the 2017 Uniform Reporting System (URS) Output Tables for Utah. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: mental-health-services, national-outcome-measures, samhsa, substance-abuse-treatment, utah-mental-health
Organization: U.S. Department of Health & Human Services
2010 CMHS Uniform Reporting System (URS) Output Tables for Nevada

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2010. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-data, mental-health-services, nevada-mental-health, noms-measures, samhsa
Organization: U.S. Department of Health & Human Services
Partial identification by site-directed mutagenesis of a cell growth inhibitory site on the human galectin-1 molecule

Background
          Previous work, by us and others, has shown that mammalian galectins-1 have a growth-inhibitory activity for mammalian cells which is apparently independent of their β-galactoside binding site.
        
        
          Results
          We have made recombinant human galectin-1 as a bacterial fusion protein with an N-terminal hexahistidine tag. This protein displays both haemagglutination and growth-inhibitory activities, even in the presence of the hexahistidine tag. Site-directed mutagenesis of this protein has confirmed the independent nature of the protein sites responsible for the two biological activities. Mutant proteins were created, which displayed each activity in the absence of the other.
        
        
          Conclusions
          Human galectin-1 possesses a growth-inhibitory site, which is not part of the β-galactoside binding site. A surface loop, comprising amino acid residues 25–30, and joining two internal β-strands, forms part of the growth-inhibitory site. This region is relatively close to the N-terminus of the protein, and N-terminal substitutions or extensions also affect growth-inhibitory activity. Further experiments will be necessary to fully define this site.

Tags: cell-growth-inhibition, galectin-1, nih, recombinant-protein, site-directed-mutagenesis
Organization: U.S. Department of Health & Human Services
Reduction of post injury neointima formation due to 17β-estradiol and phytoestrogen treatment is not influenced by the pure synthetic estrogen receptor antagonist ICI 182,780 in vitro

Background
          Animal and organ culture experiments have shown beneficial inhibitory estrogen effects on post injury neointima development. The purpose of this study was to investigate whether such estrogen effects are influenced by the estrogen receptor antagonist ICI 182,780. Different concentrations of 17β-estradiol and the phytoestrogens genistein and daidzein were tested.
        
        
          Methods
          F emale New Zealand White rabbits were benumbed. In situ vascular injury of the thoracic and abdominal aorta was performed by a 3F Fogarty catheter. Segments of 5 mm were randomised and held in culture for 21 days. Three test series were performed: 1) control group – 20 μM ICI – 30 μM ICI – 40 μM ICI. 2) control group – 20 μM ICI – 40 μM 17β-estradiol – 40 μM 17β-estradiol + 20 μM ICI. 3) control group – 20 μM ICI – 40 μM daidzein – 40 μM daidzein + 20 μM ICI – 20 μM genistein – 20 μM genistein + 20 μM ICI. After 21 days the neointima-media-ratio was evaluated.
        
        
          Results
          1) Treatment with ICI 182,780 did not reduce neointima formation significantly (p = 0.05). 2) 40 μM 17β-estradiol alone (p < 0.0001) and in combination with 20 μM ICI (p < 0.0001) reduced neointima formation significantly. 3) 20 μM genistein alone (p = 0.0083) and combined with 20 μM ICI (p = 0.0053) reduced neointima formation significantly. 40 μM daidzein did not have a significant (p = 0.0637) effect.
        
        
          Conclusions
          The estrogen receptor antagonist ICI 182,780 did not modulate the inhibitory estrogen effects on post injury neointima formation. These results do not support the idea that such effects are mediated by vascular estrogen receptors.

Tags: estradiol-treatment, neointima-formation, nih, phytoestrogen-effects, vascular-injury
Organization: U.S. Department of Health & Human Services
Compound 525534: (3-Methoxy-4-isopropoxy-phenyl)-propionic acid, methyl ester

Chemical compound data from PubChem database. IUPAC Name: methyl 3-(3-methoxy-4-propan-2-yloxyphenyl)propanoate. Molecular Formula: C14H20O4. Molecular Weight: 252.31. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2018 Uniform Reporting System (URS) Table for Alaska

This is the 2018 Uniform Reporting System (URS) Output Tables for Alaska. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: alaska, block-grant, mental-health-services, noms-measures, samhsa
Organization: U.S. Department of Health & Human Services
San Francisco – SF Div: Drug-Related Emergency Department Visits, 2004-2011 - Seeking Detox

Excel file with estimates, rates, relative standard errors, trends and confidence intervals for all drug-related emergency department (ED) visits involving patients seeking detox in the San Francisco division of the  metropolitan area, covering 2004-2011. This includes nonemergency requests made through the ED for admission to detoxification unit, visits to obtain medical clearance before being incarcerated, and acute emergencies where an individual is experiencing withdrawal symptoms and requests detox. These estimates do not include patients who seek or enter the hospital\'s detox unit through other avenues.

Tags: detoxification-seeking, drug-related-ed-visits, emergency-department, samhsa, san-francisco
Organization: U.S. Department of Health & Human Services
Tumour necrosis factor-α production in fibrosing alveolitis is macrophage subset specific

Background
          Previous studies have revealed that tumour necrosis factor (TNF)-α is upregulated in fibrosing alveolitis (FA) in humans. The aim of this study was to compare the TNF-α secretory profile of alveolar macrophages (AMs) and peripheral blood monocytes (Mos) of patients with cryptogenic FA and systemic sclerosis (SSc), a rheumatological disorder in which lung fibrosis can occur. In particular, we wished to assess whether TNF-α levels differ between SSc patients with FA (FASSc) and a nonfibrotic group.
        
        
          Methods
          The reverse haemolytic plaque assay was used to evaluate the secretion of cytokine at a single cell level while immunostaining allowed subtyping of AMs and Mos.
        
        
          Results
          This study demonstrated a difference in total TNF-α levels produced by AMs when the levels in subjects with FA (cryptogenic FA and FASSc) were compared to levels in either SSc patients without FA (P = 0.0002) or normal healthy controls (P < 0.001). In addition, AMs from patients with FASSc secreted more TNF-α than those of patients with no FA (P = 0.003). In contrast, there were no significant differences in Mo TNF-α secretion between the groups. A positive correlation was found between total TNF-α level and number of neutrophils obtained by bronchoalveolar lavage from patients with FA (r = 0.49, P < 0.04). Finally, it was demonstrated that there was significant heterogeneity of TNF-α secretion and that a numerically significant subset of mononuclear phagocytes, RFD7, was responsible for more than 80% of TNF-α production.
        
        
          Conclusion
          By demonstrating the primary cell source of TNF-α in FASSc, more accurately targeted, possibly localized, anti-TNF strategies might be employed with success in the future.

Tags: fibrosing-alveolitis, macrophage-subsets, nih, systemic-sclerosis, tnf-alpha
Organization: U.S. Department of Health & Human Services
How well do second-year students learn physical diagnosis? Observational study of an objective structured clinical examination (OSCE)

Background
          Little is known about using the Objective Structured Clinical Examination (OSCE) in physical diagnosis courses. The purpose of this study was to describe student performance on an OSCE in a physical diagnosis course.
        
        
          Methods
          Cross-sectional study at Harvard Medical School, 1997–1999, for 489 second-year students.
        
        
          Results
          Average total OSCE score was 57% (range 39–75%). Among clinical skills, students scored highest on patient interaction (72%), followed by examination technique (65%), abnormality identification (62%), history-taking (60%), patient presentation (60%), physical examination knowledge (47%), and differential diagnosis (40%) (p < .0001). Among 16 OSCE stations, scores ranged from 70% for arthritis to 29% for calf pain (p < .0001). Teaching sites accounted for larger adjusted differences in station scores, up to 28%, than in skill scores (9%) (p < .0001).
        
        
          Conclusions
          Students scored higher on interpersonal and technical skills than on interpretive or integrative skills. Station scores identified specific content that needs improved teaching.

Tags: clinical-skills-assessment, medical-education, nih, osce-performance, physical-diagnosis
Organization: U.S. Department of Health & Human Services
Compound 525098: 1,3-Dichloroisopropyl isohexanoate

Chemical compound data from PubChem database. IUPAC Name: 1,2-dichloropropan-2-yl 4-methylpentanoate. Molecular Formula: C9H16Cl2O2. Molecular Weight: 227.12. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Worldwide trends in mortality from biliary tract malignancies

Background
          Intrahepatic cholangiocarcinomas are malignant tumors arising from the intrahepatic biliary tract. The pathogenesis of these tumors remains unknown. Although there is a marked global variation in prevalence, some recent studies have suggested an increase in mortality from intrahepatic cholangiocarcinoma in several regions of low endemicity. As the study of mortality trends may yield clues to possible etiological factors, we analyzed worldwide time trends in mortality from biliary tract malignancies.
        
        
          Methods
          Annual age-standardized rates for individual countries were compiled for deaths from biliary tract malignancies using the WHO database. These data were used to analyze gender and site-specific trends in mortality rates.
        
        
          Results
          An increasing trend for mortality from intrahepatic cholangiocarcinoma was noted in most countries. The average estimated annual percentage change (EAPC) in mortality rates for males was 6.9 ± 1.5, and for females was 5.1 ± 1.0. Increased mortality rates were observed in all geographic regions. Within Europe, increases were higher in Western Europe than in Central or Northern Europe. In contrast, mortality rates for extrahepatic biliary tract malignancies showed a decreasing trend in most countries, with an overall average EAPC of -0.3 ± 0.4 for males, but -1.3 ± 0.4 for females.
        
        
          Conclusions
          There has been a marked global increase in mortality from intrahepatic, but not extra-hepatic, biliary tract malignancies.

Tags: biliary-cancer-mortality, cholangiocarcinoma-trends, liver-cancer, mortality-rates, nih
Organization: U.S. Department of Health & Human Services
2018 National Directory of Mental Health Treatment Facilities

The Directory is ordered alphabetically by state, by city within each state, and by facility name within each city.Each facility listing includes codes that represent the services offered and other features of the facility, includingcodes that indicate services for hearing impaired and non-English-speaking clients. Codes are defined in a keyshown on pages v-vii. Because the services offered by a particular facility may change over time, it is always a goodidea to verify the information in this Directory when contacting a facility.The Directory is also available online in a searchable format with maps showing the location of each facility. Go tohttps://findtreatment.samhsa.gov. Since the online listing is updated regularly, more current information maybe available there than in this Directory.

Tags: behavioral-health-services, mental-health-facilities, mental-health-treatment, samhsa, treatment-directory
Organization: U.S. Department of Health & Human Services
Hyperbilirubinaemia after major thoracic surgery: comparison between open-heart surgery and oesophagectomy

Background:
          Hyperbilirubinaemia is a common occurrence in patients who are admitted to intensive care units (ICUs) after major surgery, and it is associated with high mortality. We investigated the incidence of hyperbilirubinaemia after two major types of thoracic surgery: open-heart surgery and oesophagectomy. In order to identify the risk factors associated with hyperbilirubinaemia after major surgery, we compared the incidence after open-heart surgery with that after oesophagectomy.
        
        
          Results:
          Hyperbilirubinaemia was detected in 51% of the open-heart surgery patients (n = 133) and in 64% in the oesophagectomy group (n = 74). The incidence of hyperbilirubinaemia was significantly related to the duration of surgery (P< 0.05). In the open-heart surgery group, duration of surgery was 465 ± 24 min for the patients without hyperbilirubinaemia and 571 ± 26 min for the patients with hyperbilirubinaemia. In the oesophagectomy group, the procedure durations were 415 ± 17 min and 493 ± 20 min, respectively. The overall mortality rate was 8% in the open-heart surgery group; the rate was 12% in those with hyperbilirubinaemia, but 5% in those without hyperbilirubinaemia. No members of the oesophagectomy group died, with or without hyperbilirubinaemia. Infection significantly affected both the occurrence of hyperbilirubinaemia and mortality in the open-heart surgery group. In the subgroups from the open-heart surgery group, 5% (three out of 65) of those without hyperbilirubinaemia (or evidence of infection) died; of the patients with hyperbilirubinaemia, 3% (one out of 38) of those without infection died and 23% (seven out of 30) with detected infection died.
        
        
          Conclusion:
          After open-heart surgery and oesophagectomy, approximately half of the patients studied had higher levels of serum total bilirubin. Time spent in surgery was significantly related to the occurrence of hyperbilirubinaemia. Infection significantly affected mortality and total bilirubin levels after open-heart surgery. Control of infection plays a crucial role in the prevention of hyperbilirubinaemia and in reducing mortality.

Tags: hyperbilirubinemia, nih, oesophagectomy, open-heart-surgery, thoracic-surgery
Organization: U.S. Department of Health & Human Services
2011 NSSATS State Profiles

This is a National Survey of Substance Abuse Treatment Services (N-SSATS) annual report showing all state profiles in 2011. N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 States, the District of Columbia, and other U.S. jurisdictions.

Tags: addiction-services, behavioral-health-services, samhsa, substance-abuse-treatment, treatment-facilities
Organization: U.S. Department of Health & Human Services
Compound 525176: Octapropylene glycol, diacetate

Chemical compound data from PubChem database. IUPAC Name: 2-[2-[2-[2-[2-[2-[2-(2-acetyloxypropoxy)propoxy]propoxy]propoxy]propoxy]propoxy]propoxy]propyl acetate. Molecular Formula: C28H54O11. Molecular Weight: 566.7. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 528505: Hexadecane, 3-heptyl

Chemical compound data from PubChem database. IUPAC Name: 8-ethylhenicosane. Molecular Formula: C23H48. Molecular Weight: 324.6. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services