AndreaBozzo/ceres-open-data-index huggingface dataset:
Arterial indications for the low molecular weight heparins

Antithrombotic treatment is of proven importance in patients with acute coronary syndromes. There is now accumulating evidence from several clinical trials in patients with unstable angina pectoris that the low molecular weight heparins (LMWHs) are at least as effective as unfractionated heparin. The LMWHs are easier to use, with the potential to facilitate long-term outpatient treatment. The results of the trials have actually failed to show any clear advantage, however, of the LMWHs over the standard antiplatelet treatment, despite the evidence of a sustained hypercoagulability. Potentially, the use of higher doses of LMWHs could improve the outcomes, but this is as yet unproven and could be associated with unacceptably increased risk of bleeding. During the acute phase of a stroke, aspirin is the first choice of antithrombotic drug because it reduces the risk of recurrent stroke. LMWH cannot be recommended as an antithrombotic agent for the acute treatment of stroke. Prophylactic use of low dose LMWH for the prevention of venous thromboembolism should be considered in every patient with a stroke.

Tags: acute-coronary-syndrome, antithrombotic-treatment, low-molecular-weight-heparin, nih, stroke-treatment
Organization: U.S. Department of Health & Human Services
Specificity of DNA triple helix formation analyzed by a FRET assay

Background
          A third DNA strand can bind into the major groove of a homopurine duplex DNA to form a DNA triple helix. Sequence specific triplex formation can be applied for gene targeting, gene silencing and mutagenesis.
        
        
          Results
          We have analyzed triplex formation of two polypurine triplex forming oligodeoxynucleotides (TFOs) using fluorescence resonance energy transfer (FRET). Under our conditions, the TFOs bind to their cognate double strand DNAs with binding constants of 2.6 × 105 and 2.3 × 106 M-1. Our data confirm that the polypurine TFO binds in an antiparallel orientation with respect to the polypurine DNA strand and that triplex formation requires Mg2+ions whereas it is inhibited by K+ions. The rate of formation of triple helices is slow with bimolecular rate constants of 5.6 × 104 and 8.1 × 104 min-1 M-1. Triplex dissociation was not detectable over at least 30 hours. Triplex formation is sequence specific; alteration of a single base pair within the 13 base pairs long TFOs prevents detectable triplex formation.
        
        
          Conclusion
          We have applied a FRET assay to investigate the specificity of DNA triple helix formation. This assay is homogeneous, continuous and specific, because the appearance of the FRET signal is directly correlated to triplex formation. We show that polypurine TFOs bind highly specifically to polypurine stretches in double stranded DNA. This is a prerequisite for biotechnical applications of triple helices to mediate sequence specific recognition of DNA.

Tags: dna-triple-helix, fret-assay, gene-targeting, nih, oligodeoxynucleotides
Organization: U.S. Department of Health & Human Services
Tribal Federal Medical Assistance Percentage Reference Table for FYs 2021-2022

This report provides the Federal Medical Assistance Percentages (FMAPs) for fiscal years 2021 and 2022 as well as relevant per capita income data for tribes expressing interest in operating title IV-E programs.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: affair, fiscal, fmap, medicaid, policy
Organization: U.S. Department of Health & Human Services
Shorter courses of parenteral antibiotic therapy do not appear to influence response rates for children with acute hematogenous osteomyelitis: a systematic review

Background
          Acute hematogenous osteomyelitis (AHO) occurs primarily in children and is believed to evolve from bacteremia followed by localization of infection to the metaphysis of bones. Currently, there is no consensus on the route and duration of antimicrobial therapy to treat AHO.
        
        
          Methods
          We conducted a systematic review of a short versus long course of treatment for AHO due primarily to Staphylococcus aureus in children aged 3 months to 16 years. We searched Medline, Embase and the Cochrane trials registry for controlled trials. Clinical cure rate at 6 months was the primary outcome variable, and groups receiving less than 7 days of intravenous therapy were compared with groups receiving one week or longer of intravenous antimicrobials.
        
        
          Results
          12 eligible prospective studies, one of which was randomized, were identified. The overall cure rate at 6 months for the short course of intravenous therapy was 95.2% (95% CI = 90.4, 97.7) compared to 98.8% (95% CI = 93.6, 99.8) for the longer course of therapy. There was no significant difference in the duration of oral therapy between the two groups.
        
        
          Conclusions
          Given the potential increased morbidity and cost associated with longer courses of intravenous therapy, this finding should be confirmed through a randomized controlled equivalence trial.

Tags: antibiotic-therapy, nih, osteomyelitis-treatment, pediatric-infections, systematic-review
Organization: U.S. Department of Health & Human Services
Compound 525182: Propylene glycol, monoallyl ether, acetate

Chemical compound data from PubChem database. IUPAC Name: 1-prop-2-enoxypropan-2-yl acetate. Molecular Formula: C8H14O3. Molecular Weight: 158.19. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Optimizing antibiotics in residents of nursing homes: protocol of a randomized trial

Background
          Antibiotics are frequently prescribed for older adults who reside in long-term care facilities. A substantial proportion of antibiotic use in this setting is inappropriate. Antibiotics are often prescribed for asymptomatic bacteriuria, a condition for which randomized trials of antibiotic therapy indicate no benefit and in fact harm. This proposal describes a randomized trial of diagnostic and therapeutic algorithms to reduce the use of antibiotics in residents of long-term care facilities.
        
        
          Methods
          In this on-going study, 22 nursing homes have been randomized to either use of algorithms (11 nursing homes) or to usual practise (11 nursing homes). The algorithms describe signs and symptoms for which it would be appropriate to send urine cultures or to prescribe antibiotics. The algorithms are introduced by inservicing nursing staff and by conducting one-on-one sessions for physicians using case-scenarios. The primary outcome of the study is courses of antibiotics per 1000 resident days. Secondary outcomes include urine cultures sent and antibiotic courses for urinary indications. Focus groups and semi-structured interviews with key informants will be used to assess the process of implementation and to identify key factors for sustainability.

Tags: antibiotic-use, antimicrobial-stewardship, nih, nursing-homes, urinary-tract-infections
Organization: U.S. Department of Health & Human Services
Iowa (IA)

This report presents estimates for measures of substance use and mental health based on the combined 2010 and 2011 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for Iowa for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: iowa-survey, mental-health, nsduh-data, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
National Survey of Substance Abuse Treatment Services: State Profiles 2016

The 2016 National Survey of Substance Abuse Treatment Services (N-SSATS) is an annual survey of facilities providing substance abuse treatment. The N-SSATS, conducted by the Substance Abuse and Mental Health Services Administration (SAMHSA), is designed to collect data on the location, characteristics, services offered, and number of clients in treatment at alcohol and drug abuse facilities (both public and private) throughout the 50 states, the District of Columbia, and other U.S. jurisdictions.

Tags: behavioral-health-services, n-ssats, samhsa, substance-abuse-treatment, treatment-facilities
Organization: U.S. Department of Health & Human Services
2013 NSDUH Sample Size and Population Estimates Tables (Standard Errors and P Values) - 8.1 to 8.13

These detailed tables show standard errors for sample sizes and population estimates from the 2013 National Survey on Drug Use and Health (NSDUH). Standard errors for samples sizes and population estimates are provided by age group, gender, race/ethnicity, education level, employment status, geographic area, pregnancy status, college enrollment status, and probation/parole status.

Tags: nsduh-2013, population-estimates, samhsa, standard-errors, substance-use
Organization: U.S. Department of Health & Human Services
Appendicular bone mass and knee and hand osteoarthritis in Japanese women: a cross-sectional study

Background
          It has been reported that there is an inverse association between osteoarthritis (OA) and osteoporosis. However, the relationship of bone mass to OA in a Japanese population whose rates of OA are different from Caucasians remains uncertain.
        
        
          Methods
          We studied the association of appendicular bone mineral density (second metacarpal; mBMD) and quantitative bone ultrasound (calcaneus; stiffness index) with knee and hand OA among 567 Japanese community-dwelling women. Knee and hand radiographs were scored for OA using Kellgren-Lawrence (K/L) scales. In addition, we evaluated the presence of osteophytes and of joint space narrowing. The hand joints were examined at the distal and proximal interphalangeal (DIP, PIP) and first metacarpophalangeal/carpometacarpal (MCP/CMC) joints.
        
        
          Results
          After adjusting for age and body mass index (BMI), stiffness index was significantly higher in women with K/L scale, grade 3 at CMC/MCP joint compared with those with no OA. Adjusted means of stiffness index and mBMD were significantly higher in women with definite osteophytes at the CMC/MCP joint compared to those without osteophytes, whereas there were no significant differences for knee, DIP and PIP joints. Stiffness index, but not mBMD, was higher in women with definite joint space narrowing at the CMC/MCP joint compared with those with no joint space narrowing.
        
        
          Conclusions
          Appendicular bone mass was increased with OA at the CMC/MCP joint, especially among women with osteophytes. Our findings suggest that the association of peripheral bone mass with OA for knee, DIP or PIP may be less clearcut in Japanese women than in other populations.

Tags: bone-mineral-density, japanese-women, nih, osteoarthritis, radiographic-assessment
Organization: U.S. Department of Health & Human Services
Compound 525372: 2,4-Dimethyl-1,3-dithiane

Chemical compound data from PubChem database. IUPAC Name: 2,4-dimethyl-1,3-dithiane. Molecular Formula: C6H12S2. Molecular Weight: 148.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2017 Uniform Reporting System (URS) Table for Connecticut

This is the 2017 Uniform Reporting System (URS) Output Tables for Connecticut. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-data, community-mental-health, mental-health-services, outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
MICE, a program to track and monitor animals in animal facilities

Background
          A growing number of laboratories are using the mouse as a model system in developmental biology as well as in molecular biology. Surprisingly, most of these laboratories do not have reliable computerized systems to track these animals, and the few commercial solutions available are expensive. We thus developed MICE (Mouse Information and Classification Entity), a program aimed at facilitating the monitoring of animals in animal facilities.
        
        
          Results
          This program consists of a virtual facility in which scientists can perform all the tasks done in the real world (i.e., receiving animals, breeding them, preparing cage labels, etc.). Recording of each animal (birth date, cage number, ID number, tail analysis number, parents, genetic status, genetic background, etc.) enables reliable tracking. According to any parameter of interest, animals can then be identified, grouped, sorted, moved, and so forth. Crossings are automatically processed by the program. For example, new genetic backgrounds, generation number, and anticipated due dates are determined. The program also reminds the user when new births are expected and entering newborn animals only requires a few clicks. The genealogy of each animal can be determined in two different ways, one being the visualization of a genealogical tree from which information of ancestors can be retrieved.
        
        
          Conclusion
          This standalone program, that will be distributed free of charge to academic laboratories requesting a license, represents a new and valuable tool for all animal facility users, and permits simple and reliable tracking and retrieving of animals.

Tags: animal-facility-management, animal-tracking, laboratory-animals, mouse-models, nih
Organization: U.S. Department of Health & Human Services
NSDUH 2019 Sample Design Report

This report details the 2019 sample design for the NSDUH and covers the design overview, target population, and stages of sample selection. The design overview describes how the sample design remains consistent with NSDUH’s designs since 1991 and has extended coverage of the sample since then to include additional resident populations. The 2019 target population for this report comprises a civilian, noninstitutionalized population aged 12 years or older residing within the 50 states and the District of Columbia. There are three stages of sample selection that are explained in terms of how to select and aggregate the appropriate census tracts and segments based on state sampling regions (SSRs) for each state.

Tags: nsduh, samhsa, sample-design, substance-use, survey-methodology
Organization: U.S. Department of Health & Human Services
Publications Using SAMHSA Data2016 Uniform Reporting System (URS) Table for Alabama

This is the 2016 Uniform Reporting System (URS) Output Tables for Alabama. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, evidence-based-practices, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Los Angeles-Long Beach-Santa Ana, CA

This report presents combined 2005 to 2010 National Survey on Drug Use and Health (NSDUH) results for those aged 12 or older in the Los Angeles-Long Beach-Santa Ana, CA metro area. The report includes estimates of substance use disorder, major depressive episode, illicit drug use, marijuana use, cigarette use, binge alcohol use, and the nonmedical use of prescription-type pain relievers. Results are provided for the Los Angeles-Long Beach-Santa Ana metro area, California, and the U.S. overall.

Tags: major-depressive-episode, nsduh, prescription-pain-reliever, samhsa, substance-use-disorder
Organization: U.S. Department of Health & Human Services
Elevated serum immunoglobulin E to

Background
          The possible participation of diesel exhaust inhalation during the fetal period in the elevation of IgE against pollen in postnatal life was investigated.
        
        
          Method
          The experiment was conducted using rat pups. Group I; exposed to clean air (Control). Group 2, 3; exposed to total or filtered diesel exhaust during the fetal period (Total-C-C, Filtered-C-C). Group 4, 5; exposed to total or filtered diesel exhaust during the suckling period (C-Total-C, C-Filtered-C). Group 6,7; exposed to total or filtered diesel exhaust during the weaning period (C-C-Total, C-C-Filtered). Total diesel engine exhaust contained 1.73 mg/m3 particulate matter and 0.79 ppm nitrogen dioxide; filtered exhaust contained the same gases as the total exhaust without particulate matter. Intraperitoneal injection of 5 mg crude cedar pollen was performed at 2-week intervals from the 49th day after birth.
        
        
          Results
          The mean IgE titers measured by the P-K reaction in the Control, Total-C-C, Filtered-C-C, C-Total-C, C-Filtered-C, C-C-Total and C-C-Filtered were 64.0 ± 2.7, 469.5 ± 1.6, 332.0 ± 1.7, 380.4 ± 1.7, 394.8 ± 1.7, 115.9 ± 1.3 and 57.0 ± 2.8 respectively after the fourth immunization. There were significant differences between Total-C-C, Filtered-C-C, C-Total-C, C-Filtered-C and Control (p < 0.01, p < 0.01, p < 0.05, p < 0.01, respectively). The mean IgE titers by ELISA were 0.47 ± 0.06, 0.79 ± 0.35, 0.86 ± 0.46, 0.80 ± 0.22, 0.56 ± 0.08, 0.46 ± 0.04 and 0.45 ± 0.03, respectively. IgE titers in Filtered-C-C and C-Total-C were significantly higher than in Control (p < 0.05 for each).
        
        
          Conclusions
          Inhalation of diesel exhaust during differentiation of the immune system accelerated the elevation of IgE against pollen.

Tags: cedar-pollen, diesel-exhaust, ige-levels, nih, rat-model
Organization: U.S. Department of Health & Human Services
Compound 525474: 4,7-Dithia-1,9-decadiene

Chemical compound data from PubChem database. IUPAC Name: 3-(2-prop-2-enylsulfanylethylsulfanyl)prop-1-ene. Molecular Formula: C8H14S2. Molecular Weight: 174.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Emergency Department Visits Involving Underage Alcohol Misuse: 2010 to 2013

This short report uses data from the AHRQ Healthcare Cost and Utilization Project Nationwide Emergency Department Sample (HCUP-NEDS) to assess the  prevalence of underage alcohol misuse–related emergency department (ED) visits.  Changes in the trends of alcohol-only and drug and alcohol-combination ED visits by age, gender and time are examined.

Tags: alcohol-drug-combination, emergency-department-visits, hcup-neds, samhsa, underage-alcohol-misuse
Organization: U.S. Department of Health & Human Services
Results from the 2012 National Survey on Drug Use and Health: Summary of National Findings

This report presents results from the 2012 National Survey on Drug Use and Health (NSDUH). The report includes national estimates of rates of initiation and use of illicit drugs (e.g., marijuana, cocaine, heroin, hallucinogens, inhalants, and the nonmedical use of prescription-type pain relievers, tranquilizers, stimulants, and sedatives), alcohol, and tobacco products and rates of driving under the influence of drugs or alcohol. The report also covers substance use treatment need/receipt and youth risk and prevention measures. Results are provided for age group, gender, pregnancy status, race/ethnicity, education level, employment status, geographic area, parole/probation status. Comparisons are made between 2012 and 2002 to 2011.

Tags: drug-use-trends, mental-health, nsduh-survey, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Prevention: Reorganizing Community Collaboratives

This Child Welfare Information Gateway Podcast is available on Apple Podcasts
  
  

, GooglePlay
  
  

, Spotify
  
  

, Stitcher
  
  

, SoundCloud
  
  

, and the Child Welfare Information Gateway
  
  

 website. Subscribe to receive new episodes as they are released.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: child, podcast, policy, prevention, social
Organization: U.S. Department of Health & Human Services
Compound 525407: 2-Methyl-3,6-dithiaheptane

Chemical compound data from PubChem database. IUPAC Name: 2-(2-methylsulfanylethylsulfanyl)propane. Molecular Formula: C6H14S2. Molecular Weight: 150.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 525569: N,N-Dimethyl-N'-(3-ethoxyphenyl)-benzamidine

Chemical compound data from PubChem database. IUPAC Name: N'-(3-ethoxyphenyl)-N,N-dimethylbenzenecarboximidamide. Molecular Formula: C17H20N2O. Molecular Weight: 268.35. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Seattle: Drug-Related Emergency Department Visits, 2004-2011 - Underage Drinking

Excel file with estimates, rates, relative standard errors, trends and confidence intervals for all drug-related emergency department (ED) visits involving underage drinking in the Seattle metropolitan area, covering 2004-2011.  Underage drinking includes ED visits that involve alcohol use (alone or with other drugs) for patients under the age of 21.

Tags: alcohol-related-ed, emergency-department, samhsa, seattle-metro, underage-drinking
Organization: U.S. Department of Health & Human Services
Compound 528487: Eicosane, 3-ethyl

Chemical compound data from PubChem database. IUPAC Name: 3-ethylicosane. Molecular Formula: C22H46. Molecular Weight: 310.6. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2022 National Substance Use And Mental Health Services Survey (N-SUMHSS) State Profiles

The state profiles present findings from the annual National Substance Use and Mental Health Services Survey (N-SUMHSS). Each state profile provides summary information on substance use and mental health treatment facilities’ characteristics, services offered, client numbers and a mapping of treatment facility locations within the state.

Tags: mental-health-services, n-sumhss, samhsa, substance-use-treatment, treatment-facility-data
Organization: U.S. Department of Health & Human Services