AndreaBozzo/ceres-open-data-index huggingface dataset:
2021-2022 NSDUH: Other Sources of State-Level Data

Compare state-level National Survey on Drug Use and Health (NSDUH) estimates with those from the Behavioral Risk Factor Surveillance System (BRFSS) from the Centers for Disease Control and Prevention. Comparisons are available for alcohol and cigarette use among people ages 18 or older.

Tags: alcohol-use, brfss-comparison, cigarette-use, samhsa, state-level-data
Organization: U.S. Department of Health & Human Services
2023 Uniform Reporting System (URS) Table For Colorado

This is the 2023 Uniform Reporting System (URS) Output Tables for Colorado. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: colorado-mental-health, community-mental-health, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Tennessee (TN)

This report presents estimates for measures of substance use and mental health based on the combined 2010 and 2011 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for Tennessee for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: mental-health, nsduh-survey, samhsa, substance-use, tennessee
Organization: U.S. Department of Health & Human Services
2014 CMHS Uniform Reporting System (URS) Table for New Hampshire

2014 Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for New Hampshire. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, noms-measures, samhsa, urs-data
Organization: U.S. Department of Health & Human Services
Compound 528424: Dihydrochalcone, 2',6'-dihydroxy-4,4'-dimethoxy, bis-TMS

Chemical compound data from PubChem database. IUPAC Name: 3-[4-methoxy-2,6-bis(trimethylsilyloxy)phenyl]-1-(4-methoxyphenyl)propan-1-one. Molecular Formula: C23H34O5Si2. Molecular Weight: 446.7. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Patent AT-E39951-T1: [Translated] PROCESS FOR PRODUCTION OF CORROSION PREVENTING PARTICLES.

A process for producing corrosion inhibiting particles comprising binding corrosion inhibiting cations by ion-exchange to particles of silica or alumina, which preferably have a BET surface area of at least 500 m<sup>2</sup>/g, to form cation exchanged particles, the cations of which are releaseable by further ion-exchange, the BET surface area of the cation-exchanged particles being reduced, preferably to less than 150m<sup>2</sup>/g, by subjecting the cation-exchanged particles to a heat treatment which comprises heating the particles at a temperature of from 50 to 120°C while maintaining the water content of the particles at more than 15% by weight, followed by heating with removal of water to dry the particles. An embodiment of the invention comprises heating a slurry of the cation exchanged particles followed by drying e.g. spray drying.

Tags: chemistry, innovation, patent, pubchem, research
Organization: U.S. Department of Health & Human Services
Compound 525225: Chloromethyl 8-chlorononanoate

Chemical compound data from PubChem database. IUPAC Name: chloromethyl 8-chlorononanoate. Molecular Formula: C10H18Cl2O2. Molecular Weight: 241.15. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
The gene encoding interleukin-13: a susceptibility locus for asthma and related traits

Asthma is a complex inflammatory disorder controlled by both genetic and environmental influences. Multiple genetic analyses have identified the T helper type 2 (Th2) cytokine gene cluster on chromosome 5q as a susceptibility locus for asthma. Recently, the Th2 cytokine interleukin-13 has been shown to be a critical mediator of the asthma phenotype in murine models. In this commentary we discuss several recent studies that have identified polymorphisms in the gene encoding interleukin-13. The consistent genetic associations of interleukin-13 with asthma and related traits across diverse ethnic populations in these studies provides strong support for the candidacy of this cytokine as a susceptibility locus for asthma and atopy on chromosome 5q31.

Tags: asthma-genetics, atopy-susceptibility, chromosome-5q31, interleukin-13, nih
Organization: U.S. Department of Health & Human Services
2015 CMHS Uniform Reporting System (URS) Table for South Dakota

2015 Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for South Dakota.  The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant, mental-health-services, noms-measures, samhsa, south-dakota
Organization: U.S. Department of Health & Human Services
2019 Uniform Reporting System (URS) Table for Republic of Marshall Islands

These are the 2019 Uniform Reporting System (URS) Output Tables for Republic of Marshall Islands. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-program, community-mental-health, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Long-term vitamin E supplementation fails to reduce lipid peroxidation in people at cardiovascular risk: analysis of underlying factors

Background
          Antioxidant supplementation with vitamin E had no effect in the prevention of cardiovascular diseases (CVD) in three recent large, randomized clinical trials. In order to reassess critically the role of vitamin E in CVD prevention, it is important to establish whether these results are related to a lack of antioxidant action.
        
        
          Methods
          We examined the in vivo antioxidant effect of vitamin E (300 mg/day for about three years) in 144 participants in the Primary Prevention Project (females and males, aged ≥ 50 y, with at least one major CV risk factor, but no history of CVD). Urinary 8-epi-PGF2α (isoprostane F2α-III or 15-F2t-isoP), a validated biomarker of lipid peroxidation, was measured by mass spectrometry.
        
        
          Results
          Urinary excretion of 8-epi-PGF2α [pg/mg creatinine, median (range)] was 141 (67–498) in treated and 148 (76–561) in untreated subjects (p = 0.10). Taking into account possible confounding variables, multiple regression analysis confirmed that vitamin E had no significant effect on this biomarker. Levels of 8-epi-PGF2α were in the normal range for most subjects, except smokers and those with uncontrolled blood pressure or hyperglycemia.
        
        
          Conclusions
          Prolonged vitamin E supplementation did not reduce lipid peroxidation in subjects with major cardiovascular risk factors. The observation that the rate of lipid peroxidation was near normal in a large proportion of subjects may help explain why vitamin E was not effective as an antioxidant in the PPP study and was ineffective for CVD prevention in large scale trials.

Tags: cardiovascular-risk, isoprostane-f2, lipid-peroxidation, nih, vitamin-e
Organization: U.S. Department of Health & Human Services
Color transitions in coral's fluorescent proteins by site-directed mutagenesis

Background
          Green Fluorescent Protein (GFP) cloned from jellyfish Aequorea victoria and its homologs from corals Anthozoa have a great practical significance as in vivo markers of gene expression. Also, they are an interesting puzzle of protein science due to an unusual mechanism of chromophore formation and diversity of fluorescent colors. Fluorescent proteins can be subdivided into cyan (~ 485 nm), green (~ 505 nm), yellow (~ 540 nm), and red (>580 nm) emitters.
        
        
          Results
          Here we applied site-directed mutagenesis in order to investigate the structural background of color variety and possibility of shifting between different types of fluorescence. First, a blue-shifted mutant of cyan amFP486 was generated. Second, it was established that cyan and green emitters can be modified so as to produce an intermediate spectrum of fluorescence. Third, the relationship between green and yellow fluorescence was inspected on closely homologous green zFP506 and yellow zFP538 proteins. The following transitions of colors were performed: yellow to green; yellow to dual color (green and yellow); and green to yellow. Fourth, we generated a mutant of cyan emitter dsFP483 that demonstrated dual color (cyan and red) fluorescence.
        
        
          Conclusions
          Several amino acid substitutions were found to strongly affect fluorescence maxima. Some positions primarily found by sequence comparison were proved to be crucial for fluorescence of particular color. These results are the first step towards predicting the color of natural GFP-like proteins corresponding to newly identified cDNAs from corals.

Tags: coral-proteins, fluorescent-proteins, nih, protein-fluorescence, site-directed-mutagenesis
Organization: U.S. Department of Health & Human Services
Analysis of genetic heterogeneity in the HCAR adenovirus-binding Ig1 domain in a Caucasian Flemish population

Background
          Polymorphisms in the gene that encodes the human cellular receptor for group B coxsackieviruses and adenoviruses (HCAR) could be responsible for differences in susceptibility to infections with these pathogens. Moreover, adenovirus subgroup C-mediated gene therapy could be influenced by mutations in the coding exons for the aminoterminal immunoglobulin-like 1 (Ig1) domain, which is the essential component for adenovirus fiber knob binding.
        
        
          Results
          Using two primersets in the adjacent intron sequences, HCAR exons 2 and 3, which comprise the full-length Ig1 domain, were amplified by polymerase chain reactions in 108 unselected and unrelated healthy Belgian volunteers. After nucleotide sequencing, no polymorphisms could be demonstrated in the adenovirus-binding Ig1 exons 2 and 3 of the HCAR gene.
        
        
          Conclusions
          The adenovirus-binding Ig1 domain seems to be a highly conserved region in the Caucasian population which is a reassuring finding regarding adenovector-based gene therapy.

Tags: adenovirus-binding, flemish-population, genetic-polymorphism, hcar-gene, nih
Organization: U.S. Department of Health & Human Services
2015 CMHS Uniform Reporting System (URS) Table for Delaware

2015 Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for Delaware. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, delaware-mental-health, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
2015 CMHS Uniform Reporting System (URS) Table for New Mexico

2015 Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for New Mexico.  The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: mental-health-services, new-mexico, noms-measures, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
2008-2010 NSDUH Substate Estimates of Substance Use and Mental Disorders

This report uses 2008 to 2010 National Survey on Drug Use and Health (NSDUH) to assess past year alcohol use disorder and illicit drug use disorder among persons aged 12 or older by 362 substate regions within the 50 States and the District of Columbia. Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE).

Tags: major-depressive-episode, mental-health-estimates, samhsa, substance-use-disorder, suicidal-ideation
Organization: U.S. Department of Health & Human Services
Extensive domain shuffling in transcription regulators of DNA viruses and implications for the origin of fungal APSES transcription factors

Background
          Viral DNA-binding proteins have served as good models to study the biochemistry of transcription regulation and chromatin dynamics. Computational analysis of viral DNA-binding regulatory proteins and identification of their previously undetected homologs encoded by cellular genomes might lead to a better understanding of their function and evolution in both viral and cellular systems.
        
        
          Results
          The phyletic range and the conserved DNA-binding domains of the viral regulatory proteins of the poxvirus D6R/N1R and baculoviral Bro protein families have not been previously defined. Using computational analysis, we show that the amino-terminal module of the D6R/N1R proteins defines a novel, conserved DNA-binding domain (the KilA-N domain) that is found in a wide range of proteins of large bacterial and eukaryotic DNA viruses. The KilA-N domain is suggested to be homologous to the fungal DNA-binding APSES domain. We provide evidence for the KilA-N and APSES domains sharing a common fold with the nucleic acid-binding modules of the LAGLIDADG nucleases and the amino-terminal domains of the tRNA endonuclease. The amino-terminal module of the Bro proteins is another, distinct DNA-binding domain (the Bro-N domain) that is present in proteins whose domain architectures parallel those of the KilA-N domain-containing proteins. A detailed analysis of the KilA-N and Bro-N domains and the associated domains points to extensive domain shuffling and lineage-specific gene family expansion within DNA virus genomes.
        
        
          Conclusions
          We define a large class of novel viral DNA-binding proteins and their cellular homologs and identify their domain architectures. On the basis of phyletic pattern analysis we present evidence for a probable viral origin of the fungus-specific cell-cycle regulatory transcription factors containing the APSES DNA-binding domain. We also demonstrate the extensive role of lineage-specific gene expansion and domain shuffling, within a limited set of approximately 24 domains, in the generation of the diversity of virus-specific regulatory proteins.

Tags: dna-binding-proteins, domain-shuffling, nih, transcription-regulation, viral-proteins
Organization: U.S. Department of Health & Human Services
2014 CMHS Uniform Reporting System (URS) Table for Rhode Island

2014 Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for Rhode Island. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, outcome-measures, rhode-island, samhsa
Organization: U.S. Department of Health & Human Services
Compound 525566: N,N-Dimethyl-N'-(3-chlorophenyl)-p-chlorobenzamidine

Chemical compound data from PubChem database. IUPAC Name: 4-chloro-N'-(3-chlorophenyl)-N,N-dimethylbenzenecarboximidamide. Molecular Formula: C15H14Cl2N2. Molecular Weight: 293.2. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Trend Tables  (Prevalence Estimates) - 7.1 to 7.45

These detailed tables show trends in population totals and prevalence estimates of illicit drug use, risk and protective factors, substance initiation, substance dependence/abuse, and need/receipt of substance use treatment from the 2011 National Survey on Drug Use and Health (NSDUH). Substances examined include illicit drugs (e.g., marijuana, cocaine, heroin, hallucinogens (including LSD, PCP, Ecstasy, Ketamine, DMT/AMT/Foxy, Salvia divinorum), inhalants, and the nonmedical use of prescription-type pain relievers (including OxyContin), tranquilizers, stimulants (Adderall) , sedatives (GHB, Ambien), non-prescription cold medicine, alcohol, and tobacco products (including cigarettes, smokeless tobacco, cigars, pipes). Results are provided for lifetime, past year, and past month use by age group, gender, race/ethnicity, education level, employment status, and geographic area. Comparisons are made between 2011 and 2002 through 2010.

Tags: drug-prevalence, nsduh-data, samhsa, substance-use, trend-analysis
Organization: U.S. Department of Health & Human Services
Both subtelomeric regions are required and sufficient for specific DNA fragmentation during macronuclear development in

Background:
          Programmed DNA-reorganization and DNA-elimination events take place frequently during cellular differentiation. An extreme form of such processes, involving DNA reorganization, DNA elimination and DNA fragmentation, is found during macronuclear differentiation in hypotrichous ciliates. Ciliated protozoa can therefore serve as a model system to analyze the molecular basis of these processes during cellular differentiation in eukaryotic cells.
        
        
          Results:
          Using a biological approach to identify cis-acting sequences involved in DNA fragmentation, we show that in the hypotrichous ciliate Stylonychia lemnae sequences required for specific DNA processing are localized in the 3'- and the 5'-subtelomeric regions of the macronuclear precursor sequence. They can be present at various positions in the two subtelomeric regions, and an interaction between the two regions seems to occur. Sequence comparison revealed a consensus inverted repeat in both subtelomeric regions that is almost identical to the putative Euplotes chromosome breakage sequence (E-Cbs), also identified by sequence comparison. When this sequence was mutagenized, a processed product could no longer be detected, demonstrating that the sequence plays a crucial role in DNA processing. By injecting a construct into the developing macronucleus, which exclusively contains the subtelomeric regions of the Stylonychia αl-tubulin gene, we show that subtelomeric regions are not only required but are also sufficient for DNA processing in Stylonychia.
        
        
          Conclusions:
          Our results indicate that an inverted repeat with the core sequence 5'-TGAA present in both subtelomeric regions acts as a Cbs in Stylonychia. The results allow us to propose a mechanistic model for DNA processing in this ciliate.

Tags: ciliate-protozoa, dna-fragmentation, macronuclear-development, nih
Organization: U.S. Department of Health & Human Services
Blockade of collagen-induced arthritis post-onset by antibody to granulocyte-macrophage colony-stimulating factor (GM-CSF): requirement for GM-CSF in the effector phase of disease

There is mounting evidence for a role of the growth factor granulocyte-macrophage colony-stimulating factor (GM-CSF) in inflammatory disease, including arthritis. In the present study, we examined the effectiveness of treatment of collagen-induced arthritis (CIA) with a neutralizing mAb to GM-CSF. DBA/1 mice were immunized for the development of CIA and treated at different times, and with different doses, with neutralizing mAb to GM-CSF or isotype control mAb. Anti-GM-CSF mAb treatment prior to the onset of arthritis, at the time of antigen challenge, was effective at ameliorating the ensuing disease. Modulation of arthritis was seen predominantly as a reduction in overall disease severity, both in terms of the number of limbs affected per mouse and the clinical score of affected limbs. Importantly, anti-GM-CSF mAb treatment ameliorated existing disease, seen both as a reduction in the number of initially affected limbs progressing and lower numbers of additional limbs becoming affected. By histology, both inflammation and cartilage destruction were reduced in anti-GM-CSF-treated mice, and the levels of tumor necrosis factor-a and IL-1? were also reduced in joint tissue washouts of these mice. Neither humoral nor cellular immunity to type II collagen, however, was affected by anti-GM-CSF mAb treatment. These results suggest that the major effect of GM-CSF in CIA is on mediating the effector phase of the inflammatory reaction to type II collagen. The results also highlight the essential role of GM-CSF in the ongoing development of inflammation and arthritis in CIA, with possible therapeutic implications for rheumatoid arthritis.

Tags: arthritis-treatment, collagen-induced-arthritis, dba-1-mice, gm-csf-antibody, nih
Organization: U.S. Department of Health & Human Services
2011 CMHS Uniform Reporting System (URS) Output Tables for Nevada

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2011. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: mental-health-services, nevada-mental-health, outcome-measures, samhsa, urs-data
Organization: U.S. Department of Health & Human Services
Compound 525144: Ethyl decyl isophthalate

Chemical compound data from PubChem database. IUPAC Name: 3-O-decyl 1-O-ethyl benzene-1,3-dicarboxylate. Molecular Formula: C20H30O4. Molecular Weight: 334.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services