AndreaBozzo/ceres-open-data-index huggingface dataset:
Pancreatic hyperamylasemia during acute gastroenteritis: incidence and clinical relevance

Background
          Many case reports of acute pancreatitis have been reported but, up to now, pancreatic abnormalities during acute gastroenteritis have not been studied prospectively.
        
        
          Objectives
          To evaluate the incidence and the clinical significance of hyperamylasemia in 507 consecutive adult patients with acute gastroenteritis.
        
        
          Methods
          The clinical significance of hyperamylasemia, related predisposing factors and severity of gastroenteritis were assessed.
        
        
          Results
          Hyperamylasemia was detected in 10.2 % of patients studied. Although amylasemia was found over four times the normal values in three cases, the clinical features of acute pancreatitis were recorded in only one case (0.1%). Hyperamylasemia was more likely (17%) where a microorganism could be identified in the stools (p < 0.01). Among patients with positive stool samples, Salmonella spp. and in particular S. enteritidis, was the microorganism most frequently associated with hyperamylasemia [17/84 (20.2 %) and 10/45 (22.2%), respectively], followed by Rotavirus, Clostridium difficile and Campylobacter spp. Patients with hyperamylasemia had more severe gastroenteritis with an increased incidence of fever (80 % vs 50.6 %, O.R. 3.0; P < 0.01), dehydration (18% vs 8.5%; O.R. 2.5; P < 0.05), and a higher mean number of evacuations per day (9.2 vs 7.5; P < 0.05) than those with amylasemia in the normal range. Hyperamylasemia was significantly associated with cholelithiasis, (30.0 % vs 10.7%, O.R. 3.5; P < 0.01) and chronic gastritis or duodenal ulceration (22.0 % vs 10.2%, O.R. 2.4, P < 0.05).
        
        
          Conclusions
          Hyperamylasemia is relatively frequent, and is associated with severe gastroenteritis. However, acute pancreatitis in the setting of acute gastroenteritis, is a rare event.

Tags: acute-gastroenteritis, hyperamylasemia, nih, pancreatic-enzymes, salmonella-infection
Organization: U.S. Department of Health & Human Services
Immune modulation in the treatment of respiratory infection

The limitations of currently available treatment for severe respiratory infection are demonstrated by the relatively fixed mortality associated with these infections despite advances in nutrition, vaccines, antibiotics, and critical care. This might be due in part to the changing spectrum of pathogens and development of drug resistance. Cytokines are potent molecules that function as growth factors and orchestrate both innate and adaptive immune responses. Several of these factors have entered the clinical arena to support or augment the immune response. Moreover, the use of cytokines has recently been expanded to patients without an overtly defective immune system but who have either significant infection or infection with drug resistant organisms. The use of cytokines as adjuvants in the treatment of respiratory infections is reviewed.

Tags: cytokine-therapy, immune-modulation, immunotherapy, nih, respiratory-infection
Organization: U.S. Department of Health & Human Services
Bacterial discrimination by means of a universal array approach mediated by LDR (ligase detection reaction)

Background
          PCR amplification of bacterial 16S rRNA genes provides the most comprehensive and flexible means of sampling bacterial communities. Sequence analysis of these cloned fragments can provide a qualitative and quantitative insight of the microbial population under scrutiny although this approach is not suited to large-scale screenings. Other methods, such as denaturing gradient gel electrophoresis, heteroduplex or terminal restriction fragment analysis are rapid and therefore amenable to field-scale experiments. A very recent addition to these analytical tools is represented by microarray technology.
        
        
          Results
          Here we present our results using a Universal DNA Microarray approach as an analytical tool for bacterial discrimination. The proposed procedure is based on the properties of the DNA ligation reaction and requires the design of two probes specific for each target sequence. One oligo carries a fluorescent label and the other a unique sequence (cZipCode or complementary ZipCode) which identifies a ligation product. Ligated fragments, obtained in presence of a proper template (a PCR amplified fragment of the 16s rRNA gene) contain either the fluorescent label or the unique sequence and therefore are addressed to the location on the microarray where the ZipCode sequence has been spotted. Such an array is therefore "Universal" being unrelated to a specific molecular analysis. Here we present the design of probes specific for some groups of bacteria and their application to bacterial diagnostics.
        
        
          Conclusions
          The combined use of selective probes, ligation reaction and the Universal Array approach yielded an analytical procedure with a good power of discrimination among bacteria.

Tags: 16s-rrna, bacterial-identification, ligase-detection-reaction, microbial-communities, nih
Organization: U.S. Department of Health & Human Services
Iowa (IA)

This report uses 2008 to 2010 National Survey on Drug Use and Health (NSDUH) to assess past year alcohol use disorder and illicit drug use disorder among persons aged 12 or older for Iowa overall and for substate regions within Iowa. Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE).

Tags: iowa-health, mental-health-indicators, nsduh-data, samhsa, substance-use-disorder
Organization: U.S. Department of Health & Human Services
Compound 525450: 3-Methyl-4,6-dithiaheptane

Chemical compound data from PubChem database. IUPAC Name: 2-(methylsulfanylmethylsulfanyl)butane. Molecular Formula: C6H14S2. Molecular Weight: 150.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2018 Uniform Reporting System (URS) Table for Maryland

This is the 2018 Uniform Reporting System (URS) Output Tables for Maryland. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-program, mental-health-services, national-outcome-measures, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
A necdin/MAGE-like gene in the chromosome 15 autism susceptibility region: expression, imprinting, and mapping of the human and mouse orthologues

Background
          Proximal chromosome 15q is implicated in neurodevelopmental disorders including Prader-Willi and Angelman syndromes, autistic disorder and developmental abnormalities resulting from chromosomal deletions or duplications. A subset of genes in this region are subject to genomic imprinting, the expression of the gene from only one parental allele.
        
        
          Results
          We have now identified the NDNL2 (also known as MAGE-G) gene within the 15q autistic disorder susceptibility region and have mapped its murine homolog to the region of conserved synteny near necdin (Ndn) on mouse Chr 7. NDNL2/MAGE-G is a member of a large gene family that includes the X-linked MAGE cluster, MAGED1 (NRAGE), MAGEL2 and NDN, where the latter two genes are implicated in Prader-Willi syndrome. We have now determined that NDNL2/Ndnl2 is widely expressed in mouse and human fetal and adult tissues, and that it is apparently not subject to genomic imprinting by the PWS/AS Imprinting Center.
        
        
          Conclusion
          Although NDNL2/MAGE-G in the broadly defined chromosome 15 autistic disorder susceptibility region, it is not likely to be pathogenic based on its wide expression pattern and lack of imprinted expression.

Tags: autism-spectrum-disorder, chromosome-15q, gene-expression, genomic-imprinting, nih
Organization: U.S. Department of Health & Human Services
Compound 525150: Dodecaethylene dlycol, diacetate

Chemical compound data from PubChem database. IUPAC Name: 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-acetyloxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl acetate. Molecular Formula: C28H54O15. Molecular Weight: 630.7. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Child and Family Services Review Update Volume 18, Issue 1, December 2023

This issue of Child and Family Services Reviews Update contains the following sections: Year 2 of the Round 4 CFSRs Approaches, Training Consultations Available to States for 2024, Capacity Building Centers Provide a Variety of Resources, Program Improvement Planning Gets Underway, and Spanish Translations Added to Portal.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: assessment, child, policy, scope, state
Organization: U.S. Department of Health & Human Services
Compound 525248: N''-(4-fluoro-phenyl)-N,N,N',N'-tetramethyl-guanidine

Chemical compound data from PubChem database. IUPAC Name: 2-(4-fluorophenyl)-1,1,3,3-tetramethylguanidine. Molecular Formula: C11H16FN3. Molecular Weight: 209.26. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
A comparative study of gallstones from children and adults using FTIR spectroscopy and fluorescence microscopy

Background
          Cholelithiasis is the gallstone disease (GSD) where stones are formed in the gallbladder. The main function of the gallbladder is to concentrate bile by the absorption of water and sodium. GSD has high prevalence among elderly adults. There are three major types of gallstones found in patients, White, Black and Brown. The major chemical component of white stones is cholesterol. Black and brown stones contain different proportions of cholesterol and bilirubin. The pathogenesis of gallstones is not clearly understood. Analysis of the chemical composition of gallstones using various spectroscopic techniques offers clues to the pathogenesis of gallstones. Recent years has seen an increasing trend in the number of cases involving children. The focus of this study is on the analysis of the chemical composition of gallstones from child and adult patients using spectroscopic methods.
        
        
          Methods
          In this report, we present FTIR spectroscopic studies and fluorescence microscopic analysis of gallstones obtained from 67 adult and 21 child patients. The gallstones were removed during surgical operations at Soroka University Medical Center.
        
        
          Results
          Our results show that black stones from adults and children are rich in bilirubin. Brown stones are composed of varying amounts of bilirubin and cholesterol. Green stones removed from an adult, which is rare, was found to be composed mainly of cholesterol. Our results also indicated that cholesterol and bilirubin could be the risk factors for gallstone formation in adults and children respectively. Fluorescence micrographs showed that the Ca-bilirubinate was present in all stones in different quantities and however, Cu-bilirubinate was present only in the mixed and black stones.
        
        
          Conclusions
          Analysis based on FTIR suggest that the composition of black and brown stones from both children and adults are similar. Various layers of the brown stone from adults differ by having varying quantities of cholesterol and calcium carbonate. Ring patterns observed mainly in the green stone using fluorescence microscopy have relevance to the mechanism of the stone formation. Our preliminary study suggests that bilirubin and cholesterol are the main risk factors of gallstone disease.

Tags: cholelithiasis, ftir-spectroscopy, gallstones, nih, pediatric-gallstones
Organization: U.S. Department of Health & Human Services
Compound 525542: 2-(tert-Butyl-dimethyl-silanyloxy)-3-butyl-quinoxaline

Chemical compound data from PubChem database. IUPAC Name: tert-butyl-(3-butylquinoxalin-2-yl)oxy-dimethylsilane. Molecular Formula: C18H28N2OSi. Molecular Weight: 316.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2019 Uniform Reporting System (URS) Table for Georgia

These are the 2019 Uniform Reporting System (URS) Output Tables for Georgia. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-program, georgia-urs-data, mental-health-services, noms-measures, samhsa
Organization: U.S. Department of Health & Human Services
Abdominal compartment syndrome

Intra-abdominal hypertension (IAH) associated with organ dysfunction			 defines the abdominal compartment syndrome (ACS). Elevated intra-abdominal			 pressure (IAP) adversely impacts pulmonary, cardiovascular, renal, splanchnic,			 musculoskeletal/integumentary, and central nervous system physiology. The			 combination of IAH and disordered physiology results in a clinical syndrome			 with significant morbidity and mortality. The onset of the ACS requires prompt			 recognition and appropriately timed and staged intervention in order to			 optimize outcome. The history, pathophysiology, clinical presentation, and			 management of this disorder is outlined.

Tags: abdominal-compartment-syndrome, intra-abdominal-hypertension, intra-abdominal-pressure, nih, organ-dysfunction
Organization: U.S. Department of Health & Human Services
Design of a randomized controlled trial of comprehensive rehabilitation in patients with myocardial infarction, stabilized acute coronary syndrome, percutaneous transluminal coronary angioplasty or coronary artery bypass grafting: Akershus Comprehensive C

Objectives
          1. To assess the long-term effectiveness of a comprehensive cardiac rehabilitation programme on quality of life and survival in patients with a large spectrum of cardiovascular diseases (myocardial infarction, acute coronary syndrome, percutaneous transluminal coronary angioplasty and coronary artery bypass grafting). 2. To establish the degree of correlation between expected improvement of health-related quality of life and improvement in physical function attributable to rehabilitation in the intervention group, in comparison with similar changes in the conventional care group.
        
        
          Design
          Randomized, controlled, parallel-group design (intervention/conventional care).
        
        
          Setting
          Akershus County, southeast of Oslo City, Norway.
        
        
          Participants
          500 patients, men and women, aged 40-85 years, who have sustained at least one of the above-mentioned cardiovascular diseases.
        
        
          Interventions
          8 weeks of supervised, structured physical training of three periods of 20 min per week, targeting a heart rate of 60-70% of the individual's maximum; home-based physical exercise training with the same basic schedule as in the supervised period; quantification of patients' compliance with the exercise programme by the use of wristwatches, information stored in the watch memory being retrieved once a month during the 3-year follow-up period; and life-style modification with an emphasis on the cessation of smoking and on healthy nutrition and weight control.

Tags: cardiac-rehabilitation, coronary-artery-disease, myocardial-infarction, nih, randomized-controlled-trial
Organization: U.S. Department of Health & Human Services
Compound 528346: Phenol, 2,4-dichloro, TMS

Chemical compound data from PubChem database. IUPAC Name: (2,4-dichlorophenoxy)-trimethylsilane. Molecular Formula: C9H12Cl2OSi. Molecular Weight: 235.18. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 527222: 1,4a-Dimethyl-7-propan-2-yl-3,4,5,6-tetrahydronaphthalen-2-one

Chemical compound data from PubChem database. IUPAC Name: 1,4a-dimethyl-7-propan-2-yl-3,4,5,6-tetrahydronaphthalen-2-one. Molecular Formula: C15H22O. Molecular Weight: 218.33. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2013 CMHS Uniform Reporting System (URS) Tables for Federated States of Micronesia

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Tables for Federated States of Micronesia for 2013. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program.  State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, pacific-islands-health, samhsa, urs-data
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Florida, 2013

This is a behavioral health report for the state of Florida. It uses the  National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment Services (NSSATS) to address the topics of youth substance use , youth mental health and treatment, adult mental health and treatment, substance use, substance use treatment,  for the years 2008 to 2012.

Tags: florida-behavioral-health, mental-health-florida, samhsa, substance-use-trends, youth-mental-health
Organization: U.S. Department of Health & Human Services
Compound 527383: 22,26-Dimethyl-dotriacontyl cyanide

Chemical compound data from PubChem database. IUPAC Name: 23,27-dimethyltritriacontanenitrile. Molecular Formula: C35H69N. Molecular Weight: 503.9. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
NSDUH 2022 Screening Specifications

Browse the screening questionnaire used to determine respondent eligibility for the full 2022 National Survey on Drug Use and Health (NSDUH) interview. The documents include the exact questions as they appear in the screener, along with the skip patterns that determined whether a person was asked a question or not. There are two versions available – one for in-person screenings and another for web screenings. Both include English and Spanish language questions.

Tags: mental-health, nsduh-survey, samhsa, screening-questionnaire, substance-use
Organization: U.S. Department of Health & Human Services
Supporting Evidence-Based Home Visitation Programs to Prevent Child Abuse and Neglect Project: The Chadwick Center for Children and Families at Rady Children's Hospital

Location:

To be determined; at least five counties will be identified throughout grant period

Home Visiting Program Selected:

SafeCare

Home Visiting Target Population:

Will depend on selected counties, but will target Latino families

Project Overview:
The Chadwick Center for Children and Families at Rady Children's Hospital in San Diego, California, in close partnership with the California Department of Social Services, the University of California, San Diego Department of Psychiatry, and the National SafeCare Training and Research Center, will implement the SafeCare home visitation model across multiple California counties in three, successive "cascading" cohorts. The aim of each implementation cohort will be to redirect existing home visiting service delivery in the county to the SafeCare model through strong implementation support and fidelity to the model. Each cohort will work as a "Learning Community" to aid in accelerating the pace of implementation, reinforcing model fidelity, and increasing the likelihood that changes are sustained. The ultimate goal of cascading implementation will be to expand the breadth of services geographically and the depth of local capacity to teach and support other practitioners. Also, during the grant period, The Chadwick Center will complete a full cultural adaptation of SafeCare for Latino families, including staff support and coaching in Spanish. To evaluate their efforts, the Chadwick Center intends to assess reach, progress, fidelity, and maltreatment re-reports to provide feedback on how implementation can be improved.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: abuse, grant, intervention, neglect, prevention
Organization: U.S. Department of Health & Human Services
2023 Uniform Reporting System (URS) Table For Florida

This is the 2023 Uniform Reporting System (URS) Output Tables for Florida. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-data, florida-urs, mental-health-services, noms-measures, samhsa
Organization: U.S. Department of Health & Human Services