AndreaBozzo/ceres-open-data-index huggingface dataset:
Retroviral expression of a kinase-defective IGF-I receptor suppresses growth and causes apoptosis of CHO and U87 cells in-vivo

Background
          Phosphatidylinositol-3,4,5-triphosphate (PtdInsP3) signaling is elevated in many tumors due to loss of the tumor suppressor PTEN, and leads to constitutive activation of Akt, a kinase involved in cell survival. Reintroduction of PTEN in cells suppresses transformation and tumorigenicity. While this approach works in-vitro, it may prove difficult to achieve in-vivo. In this study, we investigated whether inhibition of growth factor signaling would have the same effect as re-expression of PTEN.
        
        
          Methods
          Dominant negative IGF-I receptors were expressed in CHO and U87 cells by retroviral infection. Cell proliferation, transformation and tumor formation in athymic nude mice were assessed.
        
        
          Results
          Inhibition of IGF-IR signaling in a CHO cell model system by expression of a kinase-defective IGF-IR impairs proliferation, transformation and tumor growth. Reduction in tumor growth is associated with an increase in apoptosis in-vivo. The dominant-negative IGF-IRs also prevented growth of U87 PTEN-negative glioblastoma cells when injected into nude mice. Injection of an IGF-IR blocking antibody αIR3 into mice harboring parental U87 tumors inhibits tumor growth and increases apoptosis.
        
        
          Conclusion
          Inhibition of an upstream growth factor signal prevents tumor growth of the U87 PTEN-deficient glioma to the same extent as re-introduction of PTEN. This result suggests that growth factor receptor inhibition may be an effective alternative therapy for PTEN-deficient tumors.

Tags: apoptosis, igf-1-receptor, kinase-defective, nih, tumor-growth
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Nebraska, 2015

This is a behavioral health report for the state of Nebraska. The report utilizes data from the National Survey on Drug Use and Health (NSDUH), and the Uniform Reporting System. The topics addressed in the report include youth substance use, youth mental health and treatment, mental health and treatment, substance use and substance use treatment.

Tags: mental-health-treatment, nebraska-behavioral-health, nsduh-data, samhsa, youth-substance-use
Organization: U.S. Department of Health & Human Services
The association between iliocostal distance and the number of vertebral and non-vertebral fractures in women and men registered in the Canadian Database For Osteoporosis and Osteopenia (CANDOO)

Background
          The identification of new methods of evaluating patients with osteoporotic fracture should focus on their usefulness in clinical situations such that they are easily measured and applicable to all patients. Thus, the purpose of this study was to examine the association between iliocostal distance and vertebral and non-vertebral fractures in patients seen in a clinical setting.
        
        
          Methods
          Patient data were obtained from the Canadian Database of Osteoporosis and Osteopenia (CANDOO). A total of 549 patients including 508 women and 41 men participated in this cross-sectional study. There were 142 women and 18 men with prevalent vertebral fractures, and 185 women and 21 men with prevalent non-vertebral fractures.
        
        
          Results
          In women multivariable regression analysis showed that iliocostal distance was negatively associated with the number of vertebral fractures (-0.18, CI: -0.27, -0.09; adjusted for bone mineral density at the Ward's triangle, epilepsy, cerebrovascular disease, inflammatory bowel disease, etidronate use, and calcium supplement use) and for the number of non-vertebral fractures (-0.09, CI: -0.15, -0.03; adjusted for bone mineral density at the trochanter, cerebrovascular disease, inflammatory bowel disease, and etidronate use). However, in men, multivariable regression analysis did not demonstrate a significant association between iliocostal distance and the number of vertebral and non-vertebral fractures.
        
        
          Conclusions
          The examination of iliocostal distance may be a useful clinical tool for assessment of the possibility of vertebral fractures. The identification of high-risk patients is important to effectively use the growing number of available osteoporosis therapies.

Tags: candoo, iliocostal-distance, nih, osteoporosis, vertebral-fractures
Organization: U.S. Department of Health & Human Services
Voluntary Cooperative Information System (VCIS) Multi-Year File (1982-1995)

The Voluntary Cooperative Information System (VCIS) compiled aggregate information about children who experienced substitute care in the United States between 1982 and 1995. Substitute care data were collected voluntarily by the American Public Welfare Association (APWA) from state agencies administering public child welfare programs. VCIS data are annual state-level counts of children entering, in, and exiting substitute care, tabulated by various child attributes such as age, sex, race/ethnicity, or duration of care. The VCIS therefore provides a basis for both cross-sectional and longitudinal state-level analysis, including through linkage to aggregated data from its successor, the Adoption and Foster Care Reporting and Analysis System (AFCARS).

Investigators: Original Investigator(s): American Public Human Service Association (APHSA)
(Formerly American Public Welfare Association (APWA))
Secondary Investigators:Alexander F. Roehrkasse, Ph.D. - 
Duke University
Chiara Fontaine - 
Cornell University
LeAnn McDowall - 
Cornell University
Sarah Sernaker, M.S. - 
Duke University
Clayton C. Covington, B.A.
- Duke University

Tags: abuse, care, ndacan, policy, reporting
Organization: U.S. Department of Health & Human Services
Compound 528351: 5-Aminoadamantan-2-one

Chemical compound data from PubChem database. IUPAC Name: 5-aminoadamantan-2-one. Molecular Formula: C10H15NO. Molecular Weight: 165.23. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Independent predictors of breastfeeding intention in a disadvantaged population of pregnant women

Background
          Breastfeeding rates in Scotland are very low, particularly in the more disadvantaged areas. Despite a number of interventions to promote breastfeeding very few women actually intend to breastfeed their baby. The aim of this study was to identify personal and social factors independently associated with intention to breastfeed.
        
        
          Methods
          Nine hundred and ninety seven women from two socio-economically disadvantaged housing estates located on the outskirts of Glasgow participated in a study that aimed to increase the prevalence of breastfeeding. Self-administered questionnaires completed by each participant collected information in early pregnancy, prior to exposure to the study intervention, on feeding intention, previous feeding experience and socio-demographic data.
        
        
          Results
          Five factors were independently predictive of breastfeeding intention. These were previous breastfeeding experience, living with a partner, smoking, parity and maternal age. After adjusting for these five factors, neither deprivation nor receipt of milk tokens provided useful additional predictive information.
        
        
          Conclusion
          In this population of socially disadvantaged pregnant women we identified five variables that were independently predictive of breastfeeding intention. These variables could be useful in identifying women at greatest risk of choosing not to breastfeed. Appropriate promotional efforts could then be designed to give due consideration to individual circumstances.

Tags: breastfeeding-intention, infant-feeding, nih, pregnant-women, socioeconomic-disadvantage
Organization: U.S. Department of Health & Human Services
2011 CMHS Uniform Reporting System (URS) Output Tables for Illinois

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2011. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: illinois, mental-health-services, national-outcome-measures, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
2023 Uniform Reporting System (URS) Table For Arkansas

This is the 2023 Uniform Reporting System (URS) Output Tables for Arkansas. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: arkansas, mental-health-services, national-outcome-measures, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
Voluntary self-poisoning as a cause of admission to a tertiary hospital internal medicine clinic in Piraeus, Greece within a year

Background
          Out of 1705 patients hospitalised for various reasons in the 3rd Internal Medicine Department of the Regional General Hospital of Nikaea, in Piraeus, 146(8,5%) persons were admitted for drug intoxication between November 1999 and November 2000.
        
        
          Methods
          On average, these persons [male 50(34,2%) – female 96(65,8%)] were admitted to the hospital within 3.7 hours after taking the drug.
        
        
          Results
          The drugs that were more frequently taken, alone or in combination with other drugs, were sedatives (67.1%), aspirins and analgesics (mainly paracetamol) (43.5%). 38.3% of patients had a mental illness history, 31.5% were in need of psychiatric help and 45.2% had made a previous suicide attempt. No death occurred during the above period and the outcome of the patients' health was normal. After mental state examination, the mental illnesses diagnosed were depression (20.96%), psychosis (15.32%), dysthymic disorder (16,2%), anxiety disorder (22.58%) and personality disorder (8.87%).
        
        
          Conclusions
          Self-poisoning remains a crucial problem. The use of paracetamol and sedatives are particularly important in the population studied. Interpersonal psychiatric therapy may be a valuable treatment after people tried to poison themselves.

Tags: drug-intoxication, mental-illness, nih, self-poisoning, suicide-attempt
Organization: U.S. Department of Health & Human Services
Compound 525642: N,N-Dimethyl-N'-pentyl-benzamidine

Chemical compound data from PubChem database. IUPAC Name: N,N-dimethyl-N'-pentylbenzenecarboximidamide. Molecular Formula: C14H22N2. Molecular Weight: 218.34. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: New Jersey, 2015

This is a behavioral health report for the state of New Jersey. The report utilizes data from the National Survey on Drug Use and Health (NSDUH), and the Uniform Reporting System. The topics addressed in the report include youth substance use, youth mental health and treatment, mental health and treatment, substance use and substance use treatment.

Tags: behavioral-health, mental-health, samhsa, substance-use, youth-mental-health
Organization: U.S. Department of Health & Human Services
2014 CMHS Uniform Reporting System (URS) Table for Northern Mariana Islands

2014 Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for Northern Mariana Islands. The URS territories reporting system is collected annually to support the Community Mental Health Services Block Grant program. Territories Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: mental-health-services, national-outcome-measures, northern-mariana-islands, samhsa, urs-data
Organization: U.S. Department of Health & Human Services
Deletion of the alpha-synuclein locus in a subpopulation of C57BL/6J inbred mice

Background
          The presynaptic protein α-synuclein is involved in a range of neurodegenerative diseases. Here we analyze potential compensatory mechanisms in α-synuclein null mutant mice. Furthermore, the findings reveal problems that may be associated with inbred mouse strains.
        
        
          Results
          Expression profiling by cDNA array technology in a transgenic mouse model revealed striking differences only in the expression level of α-synuclein. This was caused by a chromosomal deletion of the α-synuclein locus in the C57BL/6J inbred strain used for backcrossing. However, the deletion is only present in a subpopulation of C57BL/6J mice, namely animals from Harlan. No other genes are known to be affected by the deletion, which is estimated to be smaller than 2 cM. We propose to name this strain C57BL/6S. C57BL/6S animals appear phenotypically normal. They show no upregulation of β-synuclein or γ-synuclein, excluding a compensatory mechanism. Also, the expression of synphilin-1 was unaffected.
        
        
          Conclusions
          The C57BL/6S strain should help in the understanding of the physiological function of α-synuclein and its involvement in synucleinopathies. Also, the findings exemplify unexpected complications that may arise during the study of transgenic models or inbred strains, in particular when combined with genome wide screening techniques.

Tags: alpha-synuclein, c57bl6j-mice, gene-deletion, nih, parkinsons-disease
Organization: U.S. Department of Health & Human Services
NSDUH 2015 Methodological Resource Book (MRB)

This Methodological Resource Book (MRB) is intended to serve as documentation of survey materials and methodology associated with the 2015 National Survey on Drug Use and Health (NSDUH). The MRB includes details associated with data collection and processing, including sampling, instrument testing and development, weighting, imputation, and statistical analyses and inferences.

Tags: data-collection, samhsa, statistical-analysis, substance-use, survey-methodology
Organization: U.S. Department of Health & Human Services
2017 Uniform Reporting System (URS) Table for Florida

This is the 2017 Uniform Reporting System (URS) Output Tables for Florida. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: florida-mental-health, mental-health-services, noms-measures, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
2023 Uniform Reporting System (URS) Table For Wyoming

This is the 2023 Uniform Reporting System (URS) Output Tables for Wyoming. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-data, mental-health-services, national-outcome-measures, samhsa, wyoming-mental-health
Organization: U.S. Department of Health & Human Services
Sample Size and Population Estimate Tables (Prevalence Estimates) - 3.1 to 3.8

These detailed tables show sample sizes and population estimates from the 2012 National Survey on Drug Use and Health (NSDUH) Mental Health Detailed Tables. Samples sizes and population estimates are provided age group, gender, race/ethnicity, education level, employment status, county type, poverty level, insurance status, overal health, and geographic area.

Tags: mental-health, nsduh-2012, prevalence-estimates, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Using automated medical records for rapid identification of illness syndromes (syndromic surveillance): the example of lower respiratory infection

Background
          Gaps in disease surveillance capacity, particularly for emerging infections and bioterrorist attack, highlight a need for efficient, real time identification of diseases.
        
        
          Methods
          We studied automated records from 1996 through 1999 of approximately 250,000 health plan members in greater Boston.
        
        
          Results
          We identified 152,435 lower respiratory infection illness visits, comprising 106,670 episodes during 1,143,208 person-years. Three diagnoses, cough (ICD9CM 786.2), pneumonia not otherwise specified (ICD9CM 486) and acute bronchitis (ICD9CM 466.0) accounted for 91% of these visits, with expected age and sex distributions. Variation of weekly occurrences corresponded closely to national pneumonia and influenza mortality data. There was substantial variation in geographic location of the cases.
        
        
          Conclusion
          This information complements existing surveillance programs by assessing the large majority of episodes of illness for which no etiologic agents are identified. Additional advantages include: a) sensitivity, uniformity and efficiency, since detection of events does not depend on clinicians' to actively report diagnoses, b) timeliness, the data are available within a day of the clinical event; and c) ease of integration into automated surveillance systems.
          These features facilitate early detection of conditions of public health importance, including regularly occurring events like seasonal respiratory illness, as well as unusual occurrences, such as a bioterrorist attack that first manifests as respiratory symptoms. These methods should also be applicable to other infectious and non-infectious conditions. Knowledge of disease patterns in real time may also help clinicians to manage patients, and assist health plan administrators in allocating resources efficiently.

Tags: icd9-codes, lower-respiratory-infection, nih, pneumonia-influenza, syndromic-surveillance
Organization: U.S. Department of Health & Human Services
Options for NEICE: Two States’ Perspectives

This state panel discussed options for implementing the National Electronic Interstate Compact Enterprise (NEICE). NEICE is the electronic exchange of data regarding the Interstate Compact on the Placement of Children (ICPC). New York staff shared their perspective on using the NEICE Case Management System (CMS) and Ohio staff shared their perspective on incorporating ICPC functionality in the state system with a direct data exchange with the NEICE clearinghouse. In addition, representatives from APHSA answered questions related to the NEICE clearinghouse and to CMS. This webinar concluded with a question and answer session about both options.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: case, policy, reporting, sery, time
Organization: U.S. Department of Health & Human Services
Anti-TNF-α antibody allows healing of joint damage in polyarthritic transgenic mice

Anti-tumor-necrosis-factor-α (TNF-α) monoclonal antibody was used to treat Tg197 transgenic mice, which constitutively produce human TNF-α (hTNF-α) and develop a progressive polyarthritic disease. Treatment of both young (7- or 8-week-old) and aged (27- or 28-week-old) mice commenced when at least two limbs showed signs of moderate to severe arthritis. The therapeutic efficacy of anti-TNF-α antibody was assessed using various pathological indicators of disease progression. The clinical severity of arthritis in Tg197 mice was significantly reduced after anti-TNF-α treatment in comparison with saline-treated mice and in comparison with baseline assessments in both young and aged mice. The treatment with anti-TNF-α prevented loss of body weight. Inflammatory pathways as reflected by elevated circulating hTNF-α and local expression of various proinflammatory mediators were all diminished by anti-TNF-α treatment, confirming a critical role of hTNF-α in this model of progressive polyarthritis. More importantly, the amelioration of the disease was associated with reversal of existing structural damage, including synovitis and periosteal bone erosions evident on histology. Repair of cartilage was age dependent: reversal of cartilage degradation after anti-TNF-α treatment was observed in young mice but not in aged mice.

Tags: joint-damage, nih, polyarthritis, tnf-alpha-antibody, transgenic-mice
Organization: U.S. Department of Health & Human Services
State Child Abuse and Neglect (SCAN) Policies Database 2019

The State Child Abuse and Neglect (SCAN) Policies Database, supported by the Office of Planning, Research, and Evaluation, Administration for Children and Families, U.S. Department of Health and Human services, compiles data on state definitions and policies related to the surveillance of child maltreatment incidence and associated risk and protective factors. The SCAN Policies Database is a resource for researchers, analysts, and others who are interested in examining differences in definitions and policies on child maltreatment across states. A primary use of these data is to allow researchers to link the analytic files to other data sources to address important questions about how variations in states’ definitions and policies are associated with the incidence of child maltreatment, the child welfare system response, and ultimately child safety and well-being. Other data sources that can be linked with the SCAN Policies Database include data from the National Child Abuse and Neglect Data System (NCANDS), the Adoption and Foster Care Analysis and Reporting System (AFCARS), state administrative data, and survey data. When data from the SCAN Policies Database are linked with other data sources, these data can be used to answer key research questions about how variations in definitions and policies are associated with key aspects of understanding the incidence of child abuse and neglect. The SCAN Policies Database includes state definitions and policies from the 50 states, the District of Columbia, and the Commonwealth of Puerto Rico. The data were collected from a review of statutes and state documentation between May 2019 - June 2020.

Investigators: Elizabeth C. Weigensberg, PhD - 
Mathematica
Nuzhat Islam, MS - 
Mathematica
Jean Knab, PhD - 
Mathematica
Mary A. Grider, MBA - 
Mathematica
Jeremy Page, MA - 
Mathematica
Sarah Bardin, BA - 
Mathematica

Tags: abuse, care, ndacan, policy, reporting
Organization: U.S. Department of Health & Human Services
Publications Using SAMHSA Data2017 Uniform Reporting System (URS) Table for South Carolina

This is the 2017 Uniform Reporting System (URS) Output Tables for South Carolina. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: mental-health-services, outcome-measures, samhsa, south-carolina, urs-data
Organization: U.S. Department of Health & Human Services