AndreaBozzo/ceres-open-data-index huggingface dataset:
Compound 525601: N,N-Dimethyl-N'-(4-methoxyphenyl)-p-methylbenzamidine

Chemical compound data from PubChem database. IUPAC Name: N'-(4-methoxyphenyl)-N,N,4-trimethylbenzenecarboximidamide. Molecular Formula: C17H20N2O. Molecular Weight: 268.35. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Macrophages in rheumatoid arthritis

The abundance and activation of macrophages in the inflamed synovial membrane/pannus significantly correlates with the severity of rheumatoid arthritis (RA). Although unlikely to be the 'initiators' of RA (if not as antigen-presenting cells in early disease), macrophages possess widespread pro-inflammatory, destructive, and remodeling capabilities that can critically contribute to acute and chronic disease. Also, activation of the monocytic lineage is not locally restricted, but extends to systemic parts of the mononuclear phagocyte system. Thus, selective counteraction of macrophage activation remains an efficacious approach to diminish local and systemic inflammation, as well as to prevent irreversible joint damage.

Tags: joint-damage, macrophage-activation, nih, rheumatoid-arthritis, synovial-inflammation
Organization: U.S. Department of Health & Human Services
Treatment Episode Data Set (TEDS) 2009 Discharges from Substance Abuse Treatment Services

This report presents results from the Treatment Episode Data Set (TEDS) for clients aged 12 and older discharged from substance abuse treatment in 2009. The report provides information on treatment completion, length of stay in treatment, and demographic and substance abuse characteristics of people discharged from alcohol or drug treatment in facilities that reported to individual state administrative data systems.

Tags: alcohol-drug-treatment, samhsa, substance-abuse-treatment, teds-discharges, treatment-episode-data
Organization: U.S. Department of Health & Human Services
Genomic approaches to research in pulmonary hypertension

Genomics, or the study of genes and their function, is a burgeoning field with many new technologies. In the present review, we explore the application of genomic approaches to the study of pulmonary hypertension (PH). Candidate genes, important to the pathobiology of the disease, have been investigated. Rodent models enable the manipulation of selected genes, either by transgenesis or targeted disruption. Mutational analysis of genes in the transforming growth factor-β family have proven pivotal in both familial and sporadic forms of primary PH. Finally, microarray gene expression analysis is a robust molecular tool to aid in delineating the pathobiology of this disease.

Tags: gene-expression, genetic-mutation, genomic-analysis, nih, pulmonary-hypertension
Organization: U.S. Department of Health & Human Services
Are women and providers satisfied with antenatal care? Views on a standard and a simplified, evidence-based model of care in four developing countries

Background
          This study assessed women and providers' satisfaction with a new evidence-based antenatal care (ANC) model within the WHO randomized trial conducted in four developing countries. The WHO study was a randomized controlled trial that compared a new ANC model with the standard type offered in each country. The new model of ANC emphasized actions known to be effective in improving maternal or neonatal health, excluded other interventions that have not proved to be beneficial, and improved the information component, especially alerting pregnant women to potential health problems and instructing them on appropriate responses. These activities were distributed within four antenatal care visits for women that did not need any further assessment.
        
        
          Methods
          Satisfaction was measured through a standardized questionnaire administered to a random sample of 1,600 pregnant women and another to all antenatal care providers.
        
        
          Results
          Most women in both arms expressed satisfaction with ANC. More women in the intervention arm were satisfied with information on labor, delivery, family planning, pregnancy complications and emergency procedures. More providers in the experimental clinics were worried about visit spacing, but more satisfied with the time spent and information provided.
        
        
          Conclusions
          Women and providers accepted the new ANC model generally. The safety of fewer visits for women without complications with longer spacing would have to be reinforced, if such a model is to be introduced into routine practice.

Tags: antenatal-care, developing-countries, maternal-health, nih, patient-satisfaction
Organization: U.S. Department of Health & Human Services
National Mental Health Services Survey (N-MHSS): 2012, Data on Mental Health Treatment Facilities

This an annual report that presents findings from the 2012 National Mental Health Services Survey (N-MHSS) conducted from September 2012 through February 2013. The N-MHSS collects information from all the known facilities in the United States, both public and private, that provide mental health treatment services to people with mental illness. The N-MHSS is designed to collect data on the location, characteristics, and utilization of organized mental health treatment service providers throughout the 50 states, the District of Columbia, and the U.S. territories.

Tags: mental-health-services, mental-illness, samhsa, service-utilization, treatment-facilities
Organization: U.S. Department of Health & Human Services
Compound 525606: N,N-Dimethyl-N'-(4-nitrophenyl)-benzamidine

Chemical compound data from PubChem database. IUPAC Name: N,N-dimethyl-N'-(4-nitrophenyl)benzenecarboximidamide. Molecular Formula: C15H15N3O2. Molecular Weight: 269.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Antibodies against prM protein distinguish between previous infection with dengue and Japanese encephalitis viruses.

Background
          In Southeast Asia, dengue viruses often co-circulate with other flaviviruses such as Japanese encephalitis virus, and due to the presence of shared antigenic epitopes it is often difficult to use serological methods to distinguish between previous infections by these flaviviruses.
        
        
          Results
          Convalescent sera from 69 individuals who were known to have had dengue or Japanese encephalitis virus infection were tested by western blotting against dengue, Japanese encephalitis and West Nile virus antigens. We determined that individuals who had been infected with dengue viruses had IgG responses against the premembrane protein of dengue viruses but not Japanese encephalitis, whereas individuals who had been infected with Japanese encephalitis had IgG specific for the premembrane protein of Japanese encephalitis virus but not the dengue viruses. None reacted with the premembrane protein of West Nile virus. Using the Pearson Chi Square test, it was determined that the difference between the two groups was highly significant with a p value of <0.001.
        
        
          Conclusion
          The use of flavivirus premembrane protein in seroepidemiological studies will be useful in determining what flaviviruses have circulated in a community.

Tags: antibody-response, dengue-virus, flavivirus-infection, japanese-encephalitis, nih
Organization: U.S. Department of Health & Human Services
Minneapolis: Drug-Related Emergency Department Visits, 2004-2011 - Underage Drinking

Excel file with estimates, rates, relative standard errors, trends and confidence intervals for all drug-related emergency department (ED) visits involving underage drinking in the Minneapolis metropolitan area, covering 2004-2011.  Underage drinking includes ED visits that involve alcohol use (alone or with other drugs) for patients under the age of 21.

Tags: alcohol-related-visits, emergency-department, minneapolis, samhsa, underage-drinking
Organization: U.S. Department of Health & Human Services
Denver: Drug-Related Emergency Department Visits, 2004-2011 - Underage Drinking

Excel file with estimates, rates, relative standard errors, trends and confidence intervals for all drug-related emergency department (ED) visits involving underage drinking in the Denver metropolitan area, covering 2004-2011.  Underage drinking includes ED visits that involve alcohol use (alone or with other drugs) for patients under the age of 21.

Tags: alcohol-related-ed-visits, denver-metro-area, emergency-department-data, samhsa, underage-drinking
Organization: U.S. Department of Health & Human Services
Compound 526853: 5-Acetyl-2,3-dihydro-1,4-thiazine

Chemical compound data from PubChem database. IUPAC Name: 1-(3,4-dihydro-2H-1,4-thiazin-5-yl)ethanone. Molecular Formula: C6H9NOS. Molecular Weight: 143.21. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Second Youth Internet Safety Survey (YISS-2)

The Second Youth Internet Safety Survey (YISS-2) was conducted in 2005 and designed to update and expand upon the previous Youth Internet Safety Survey (YISS-1) conducted in 1999/2000. This study involves telephone interviews with a national sample of 1500 youth Internet users, ages 10 to 17. The interviews measure changes in the frequency and nature of unwanted online exposures to sexual solicitations and pornography since YISS-1. Additionally, YISS-2 goes beyond the findings of YISS-1 by including more details about the impact on youth of unwanted exposure to sexual solicitations and pornography and the use and efficacy of filtering and blocking software. Findings from YISS-2 showed increased proportions of youth Internet users were encountering unwanted exposures to sexual material and online harassment, but decreased proportions were receiving unwanted sexual solicitations.

Investigators: David Finkelhor, Ph.D.
University of New Hampshire Durham, NH

Kimberly J. Mitchell, Ph.D.
University of New Hampshire Durham, NH

Janis Wolak, J.D.
University of New Hampshire Durham, NH

Tags: abuse, care, ndacan, policy, reporting
Organization: U.S. Department of Health & Human Services
Table 22. Needing But Not Receiving Treatment for Illicit Drug Use in the Past Year among Persons Aged 12 or Older, by State and Substate Regions: Percentages, Annual Averages Based on 2010, 2011, and 2012 NSDUHs

Table 22. Needing But Not Receiving Treatment for Illicit Drug Use in the Past Year among Persons Aged 12 or Older, by State and Substate Regions: Percentages, Annual Averages Based on 2010, 2011, and 2012 NSDUHs

Tags: illicit-drug-use, samhsa, substance-use-disorder, treatment-gap, unmet-treatment-need
Organization: U.S. Department of Health & Human Services
Signal analysis of behavioral and molecular cycles

Background
          Circadian clocks are biological oscillators that regulate molecular, physiological, and behavioral rhythms in a wide variety of organisms. While behavioral rhythms are typically monitored over many cycles, a similar approach to molecular rhythms was not possible until recently; the advent of real-time analysis using transgenic reporters now permits the observations of molecular rhythms over many cycles as well. This development suggests that new details about the relationship between molecular and behavioral rhythms may be revealed. Even so, behavioral and molecular rhythmicity have been analyzed using different methods, making such comparisons difficult to achieve. To address this shortcoming, among others, we developed a set of integrated analytical tools to unify the analysis of biological rhythms across modalities.
        
        
          Results
          We demonstrate an adaptation of digital signal analysis that allows similar treatment of both behavioral and molecular data from our studies of Drosophila. For both types of data, we apply digital filters to extract and clarify details of interest; we employ methods of autocorrelation and spectral analysis to assess rhythmicity and estimate the period; we evaluate phase shifts using crosscorrelation; and we use circular statistics to extract information about phase.
        
        
          Conclusion
          Using data generated by our investigation of rhythms in Drosophila we demonstrate how a unique aggregation of analytical tools may be used to analyze and compare behavioral and molecular rhythms. These methods are shown to be versatile and will also be adaptable to further experiments, owing in part to the non-proprietary nature of the code we have developed.

Tags: behavioral-cycles, circadian-rhythms, molecular-cycles, nih, signal-analysis
Organization: U.S. Department of Health & Human Services
2019 Uniform Reporting System (URS) Table for South Dakota

These are the 2019 Uniform Reporting System (URS) Output Tables for South Dakota. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-data, mental-health-services, national-outcome-measures, samhsa, south-dakota
Organization: U.S. Department of Health & Human Services
Binding of the baculovirus very late expression factor 1 (VLF-1) to different DNA structures

Background
          Baculovirus genomes encode a gene called very late expression factor 1 (VLF-1) that is a member of the integrase (Int) family of proteins. In this report we describe the binding properties of purified Autographa californica multiple capsid nucleopolyhedrovirus (AcMNPV) VLF-1 to a number of different DNA structures including homologous regions. In addition, its enzymatic activity was examined.
        
        
          Results
          VLF-1 was expressed in a recombinant baculovirus as a fusion with both HA and HIS6 tags and its binding activity to different DNA structures was tested. No binding was evident to single and double strand structures, very low binding was observed to Y-forks, more binding was observed to three-way junctions, whereas cruciform structures showed high levels of binding. VLF-1 binding was affected by divalent cations; optimal binding to three-way junctions and cruciforms was 2 and 0 mM MgCl2, respectively. Homologous region (hr) sequences was also examined including oligomers designed to expose the hr palindrome as a hairpin, linear double strand, or H-shaped structure. Efficient binding was observed to the hairpin and H-shaped structure. No topoisomerase or endonuclease activity was detected. Sedimentation analysis indicated that *VLF-1 is present as a monomer.
        
        
          Conclusions
          An HA- and HIS-tagged version of AcMNPV VLF-1 showed structure-dependent binding to DNA substrates with the highest binding affinity to cruciform DNA. These results are consistent with the involvement of VLF-1 in the processing of branched DNA molecules at the late stages of viral genome replication. We were unable to detect enzymatic activity associated with these complexes.

Tags: baculovirus-vlf-1, dna-binding, molecular-biology, nih, viral-proteins
Organization: U.S. Department of Health & Human Services
Pharmacogenetics, pharmacogenomics and airway disease

The availability of a draft sequence for the human genome will revolutionise research into airway disease. This review deals with two of the most important areas impinging on the treatment of patients: pharmacogenetics and pharmacogenomics. Considerable inter-individual variation exists at the DNA level in targets for medication, and variability in response to treatment may, in part, be determined by this genetic variation. Increased knowledge about the human genome might also permit the identification of novel therapeutic targets by expression profiling at the RNA (genomics) or protein (proteomics) level. This review describes recent advances in pharmacogenetics and pharmacogenomics with regard to airway disease.

Tags: airway-disease, asthma-copd, nih, pharmacogenetics, pharmacogenomics
Organization: U.S. Department of Health & Human Services
Compound 525554: Decylamine, N-benzylidene-

Chemical compound data from PubChem database. IUPAC Name: N-decyl-1-phenylmethanimine. Molecular Formula: C17H27N. Molecular Weight: 245.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Table 17. 2011-2012 NSDUH Alcohol Dependence in the Past Year, by Age Group and State

Table 17. Alcohol Dependence in the Past Year, by Age Group and State: Percentages, Annual Averages Based on 2011 and 2012 NSDUHs. Results are provided by State and for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: alcohol-abuse, alcohol-dependence, nsduh-data, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Publications Using SAMHSA DataState Estimates of Adolescent Cigarette Use and  Perceptions of Risk of Smoking: 2012 and 2013

This short report uses 2012 to 2013 National Survey on Drug Use and Health (NSDUH) to assess cigarette risk perception and cigarette use among adolescents aged 12 to 17 by State. Results are shown by State for 2002-2003 and 2012-2013.

Tags: adolescent-cigarette-use, samhsa, smoking-risk-perception, state-level-estimates, youth-tobacco-use
Organization: U.S. Department of Health & Human Services
Title IV-E Reviews — Peer Reviewer Requirements and Responsibilities

Peer Reviewer participation in the IV-E Reviews requires a significant commitment of time and effort. The general requirements and responsibilities of Peer Reviewers participating in the reviews are summarized below.

When identified to participate in a IV-E Review, Peer Reviewers must:

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: child, compliance, guidance, peer, policy
Organization: U.S. Department of Health & Human Services
Emergency Department Visits for Adverse Reactions  Involving the Pain Medication Tramadol

This Drug Abuse Warning Network (DAWN) short report shows the estimated number of emergency department visits for adverse reactions involving the pain medication tramadol between 2005 and 2011.  The report specifically talks about age groups, gender, trends over time and other drugs such as cardiovascular medications, antidepressants and other pain medications.

Tags: drug-abuse-warning-network, emergency-department-visits, pain-medication-reactions, samhsa, tramadol-adverse-events
Organization: U.S. Department of Health & Human Services
NSDUH 2020 Data Collection Final Report

This report describes data collection operations for the 2020 National Survey on Drug Use and Health (NSDUH). It details the sampling, counting, and listing operations; data collection staffing; preparation of survey materials; field staff training; data collection (both in-person and web); data collection results; and quality control practices. It also includes information on Coronavirus 2019 safety protocols and training materials.The document is available as a PDF.

Tags: data-collection, mental-health, samhsa, substance-use, survey-methodology
Organization: U.S. Department of Health & Human Services
Compound 527340: 2-(4-Methylphenyl)-adamantane

Chemical compound data from PubChem database. IUPAC Name: 2-(4-methylphenyl)adamantane. Molecular Formula: C17H22. Molecular Weight: 226.36. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Highly efficient genetic transduction of primary human synoviocytes with concentrated retroviral supernatant

We are developing retroviral-mediated gene transfer to human fibroblast-like synovial cells (FLS) as one approach to characterizing genetic pathways involved in synoviocyte pathophysiology. Prior work has suggested that FLS are relatively refractory to infection by Moloney murine leukemia virus based vectors. To determine if viral titer influenced the transduction efficiency of FLS, we optimized a rapid, efficient, and inexpensive centrifugation method to concentrate recombinant retroviral supernatant. The technique was evaluated by measurement of the expression of a viral enhanced green fluorescent protein transgene in transduced cells, and by analysis of viral RNA in retroviral supernatant. Concentration (100-fold) was achieved by centrifugation of viral supernatant for four hours, with 100% recovery of viral particles. The transduction of FLS increased from approximately 15% with unconcentrated supernatant, to nearly 50% using concentrated supernatant. This protocol will be useful for investigators with applications that require efficient, stable, high level transgene expression in primary FLS.

Tags: gene-therapy, gene-transduction, nih, retroviral-vectors, synoviocytes
Organization: U.S. Department of Health & Human Services
ROCKWOOL-Duke Global Child Welfare Database

The ROCKWOOL–Duke Global Child Welfare Database (RDGCWD) compiles cross-national aggregate information from the Global North about children who experienced contact with child welfare systems (CWS) or child protective services (CPS) between 2000 and 2020. Data were collected from national child welfare agencies or national or transnational statistical agencies, and include measures of child maltreatment investigations, confirmed child maltreatment, and children in out-of-home care. Population data are included for the measurement of incidence and prevalence of system contact. The RDGCWD provides a unique resource for comparative and longitudinal research on child maltreatment and child welfare systems. However, potential unobserved variation in the definition of child maltreatment or in the administration of child welfare and child protection warrant caution in the interpretation of variation and change in system contact.

Investigators: Alexander F. Roehrkasse, Ph.D.
Duke University
Liza Becker, B.A.
Duke University
Peter Fallesen, Ph.D.
Stockholm University
Christopher Wildeman, Ph.D.
Duke University

Tags: abuse, care, ndacan, policy, reporting
Organization: U.S. Department of Health & Human Services