AndreaBozzo/ceres-open-data-index huggingface dataset:
Pruritus: a useful sign for predicting the haemodynamic changes that occur following administration of vancomycin

Introduction
          The aim of this study was to investigate the haemodynamic changes that follow the appearance of pruritus during vancomycin administration.
        
        
          Methods
          We studied 50 patients scheduled for coronary artery bypass surgery, and we compared data from patients who exhibited pruritus with those from patients who did not. After the monitoring devices had been positioned, vancomycin (15 mg/kg) was continuously infused at a constant rate over 30 min, before induction of anaesthesia. Haemodynamic profiles were recorded before vancomycin infusion (time point 1); at 15 (time point 2) and 30 min (time point 3) after the beginning of vancomycin infusion; and 15 min after vancomycin infusion had been stopped (time point 4). At each time arterial and mixed venous blood samples were drawn to calculate the shunt fraction (Qsp/Qt).
        
        
          Results
          In patients who exhibited pruritus (group A, n = 17) at time point 3 versus time point 1, systemic vascular resistance index (SVRI) and arterial oxygen tension (PaO2) decreased significantly; cardiac index (CI), stroke volume index (SVI) and Qsp/Qt increased significantly; and mean systemic pressure and heart rate were stable. Those changes were observed only in patients not treated with a β-blocker before surgery, whereas no change occurred in patients treated with the drug. In the patients who were free from pruritus (group B, n = 28), we did not observe any significant change.
        
        
          Conclusion
          The appearance of pruritus during vancomycin administration indicates that SVRI is declining, thus exposing the patient to risk for hypotension. Therapy with a β-blocker appears to confer protection against this hemodynamic reaction.

Tags: coronary-bypass, hemodynamic-changes, nih, pruritus-symptom, vancomycin-infusion
Organization: U.S. Department of Health & Human Services
Compound 527257: 9-Tridecenoic acid, methyl ester

Chemical compound data from PubChem database. IUPAC Name: methyl tridec-9-enoate. Molecular Formula: C14H26O2. Molecular Weight: 226.35. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
National Survey Of Substance Abuse Treatment Services (N-SSATS): 2020, Data On Substance Abuse Treatment Facilities

This report presents results from the 2020 National Survey of Substance Abuse Treatment Services (N-SSATS), an annual census of facilities providing substance abuse treatment. Conducted by the Substance Abuse and Mental Health Services Administration (SAMHSA), N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 states, the District of Columbia, and other jurisdictions. It is important to note that values in charts, narrative lists, and percentage distributions are calculated using actual raw numbers and rounded for presentation in this report; calculations using rounded values may produce different results.

Tags: addiction-treatment, behavioral-health-services, samhsa, substance-abuse-treatment, treatment-facility-census
Organization: U.S. Department of Health & Human Services
Compound 525479: 4-Methyl-3-thia-1-hexanethiol

Chemical compound data from PubChem database. IUPAC Name: 2-butan-2-ylsulfanylethanethiol. Molecular Formula: C6H14S2. Molecular Weight: 150.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 525537: (4-Isobutoxy-phenyl)-acetic acid, methyl ester

Chemical compound data from PubChem database. IUPAC Name: methyl 2-[4-(2-methylpropoxy)phenyl]acetate. Molecular Formula: C13H18O3. Molecular Weight: 222.28. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
National Directory of Drug and Alcohol Abuse Treatment Facilities - 1996

The National Directory of Drug and Alcohol Abuse Treatment Programs 1996 lists federal, state, local, and private facilities that provide substance abuse treatment services. The directory includes treatment facilities that are licensed, certified, or otherwise approved for inclusion in the directory by their state substance abuse agencies and that responded to the 1995 National Survey of Substance Abuse Treatment Services (N-SSATS). The information about each facility that appears in this directory was provided by that facility in response to the 1995 N-SSATS. The Substance Abuse and Mental Health Services Administration (SAMHSA) conducts the N-SSATS annually.

Tags: alcohol-abuse-treatment, n-ssats, samhsa, substance-abuse-treatment, treatment-facilities
Organization: U.S. Department of Health & Human Services
Characterisation of silent and active genes for a variable large protein of

Background
          We report the characterisation of the variable large protein (vlp) gene expressed by clinical isolate A1 of Borrelia recurrentis; the agent of the life-threatening disease louse-borne relapsing fever.
        
        
          Methods
          The major vlp protein of this isolate was characterised and a DNA probe created. Use of this together with standard molecular methods was used to determine the location of the vlp1B. recurrentis A1 gene in both this and other isolates.
        
        
          Results
          This isolate was found to carry silent and expressed copies of the vlp1B. recurrentis A1 gene on plasmids of 54 kbp and 24 kbp respectively, whereas a different isolate, A17, had only the silent vlp1B. recurrentis A17 on a 54 kbp plasmid. Silent and expressed vlp1 have identical mature protein coding regions but have different 5' regions, both containing different potential lipoprotein leader sequences. Only one form of vlp1 is transcribed in the A1 isolate of B. recurrentis, yet both 5' upstream sequences of this vlp1 gene possess features of bacterial promoters.
        
        
          Conclusion
          Taken together these results suggest that antigenic variation in B. recurrentis may result from recombination of variable large and small protein genes at the junction between lipoprotein leader sequence and mature protein coding region. However, this hypothetical model needs to be validated by further identification of expressed and silent variant protein genes in other B. recurrentis isolates.

Tags: borrelia-recurrentis, lipoprotein-leader-sequences, nih, relapsing-fever, vlp-gene
Organization: U.S. Department of Health & Human Services
The International Sepsis Forum's controversies in sepsis: corticosteroids should not be routinely used to treat septic shock

Corticosteroid treatment of severe sepsis has been one of the most controversial clinical issues in critical care. In fact, few agents can claim to have been evaluated in scores of studies spanning 3–4 decades. Yet, convincing proof that corticosteroids are useful pharmacologic agents in the treatment of this major clinical problem remains elusive. Recently, interest has resurfaced but this time the focus is on a steroid replacement approach for what has now been termed "relative adrenal insufficiency" rather than relying on the pharmacologic effects of steroids. This route holds promise, but proof remains lacking.

Tags: adrenal-insufficiency, corticosteroids-treatment, nih, sepsis-management, septic-shock
Organization: U.S. Department of Health & Human Services
Autoantibodies directed to novel components of the PM/Scl complex, the human exosome

The autoantigenic polymyositis/scleroderma (PM/Scl) complex was recently shown to be the human homologue of the yeast exosome, which is an RNA-processing complex. Our aim was to assess whether, in addition to targeting the known autoantigens PM/Scl-100 and PM/Scl-75, autoantibodies also target recently identified components of the PM/Scl complex. The prevalence of autoantibodies directed to six novel human exosome components (hRrp4p, hRrp40p, hRrp41p, hRrp42p, hRrp46p, hCsl4p) was determined in sera from patients with idiopathic inflammatory myopathy (n = 48), scleroderma (n = 11), or the PM/Scl overlap syndrome (n = 10). The sera were analyzed by enzyme-linked immunosorbent assays and western blotting using the affinity-purified recombinant proteins. Our results show that each human exosome component is recognized by autoantibodies. The hRrp4p and hRrp42p components were most frequently targeted. The presence of autoantibodies directed to the novel components of the human exosome was correlated with the presence of the anti-PM/Scl-100 autoantibody in the sera of patients with idiopathic inflammatory myopathy (IIM), as was previously found for the anti-PM/Scl-75 autoantibody. Other clear associations between autoantibody activities were not found. These results further support the conception that the autoimmune response may initially be directed to PM/Scl-100, whereas intermolecular epitope spreading may have caused the autoantibody response directed to the associated components.

Tags: autoantibody-profiling, exosome-complex, inflammatory-myopathy, myositis-scleroderma, nih
Organization: U.S. Department of Health & Human Services
Detection of chromosomes tagged with green fluorescent protein in live

Background
          Structural and dynamic studies of chromosomes tagged with green fluorescent protein (GFP) in yeast and cultured animal cells have revealed some surprises. Although this technology can be very powerful, only a few studies using this approach with developed multicellular systems have been reported for the study of chromatin behavior in situ.
        
        
          Results
          We established vectors and conditions to visualize tagged loci stably inserted in the Arabidopsis genome via GFP fused to a bacterial DNA-binding protein. Using this system, three-dimensional coordinates for tagged loci within nuclei from cells of a live plant can be directly determined with concomitant visualization of the position of the nucleolus. Chromosome polyploidization in epidermal cells at the elongation zone of the root in transgenic plants can be visualized in situ using this technique.
        
        
          Conclusion
          We have established that GFP fusion with DNA-binding proteins can be used in conjunction with concatameric binding-site arrays to track genomic loci in living Arabidopsis plants. It should now be feasible to study the mechanisms of organization and dynamics of chromatin in specific cell types during various times of plant development, taking advantage of the well developed genetic systems and resources available for Arabidopsis.

Tags: arabidopsis-genome, chromosome-visualization, gfp-tagging, live-cell-imaging, nih
Organization: U.S. Department of Health & Human Services
Children’s Bureau’s Young Adult Consultant and National Youth in Transition Database Reviewer Programs

This brief describes two Children’s Bureau programs through which young adults provide technical assistance to states about child welfare issues: the Young Adult Consultant program and the National Youth in Transition Database Reviewers program.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: child, program, reporting, scope, youth
Organization: U.S. Department of Health & Human Services
Structural and functional aspects of liver sinusoidal endothelial cell fenestrae: a review

This review provides a detailed overview of the current state of knowledge about the ultrastructure and dynamics of liver sinusoidal endothelial fenestrae. Various aspects of liver sinusoidal endothelial fenestrae regarding their structure, origin, species specificity, dynamics and formation will be explored. In addition, the role of liver sinusoidal endothelial fenestrae in relation to lipoprotein metabolism, fibrosis and cancer will be approached.

Tags: lipoprotein-metabolism, liver-fenestrae, liver-fibrosis, liver-sinusoidal-endothelial-cells, nih
Organization: U.S. Department of Health & Human Services
The role of X-chromosome inactivation in female predisposition to autoimmunity

We propose that the phenomenon of X-chromosome inactivation in females may constitute a risk factor for loss of T-cell tolerance; specifically that skewed X-chromosome inactivation in the thymus may lead to inadequate thymic deletion. Using a DNA methylation assay, we have examined the X-chromosome inactivation patterns in peripheral blood from normal females (n = 30), female patients with a variety of autoimmune diseases (n = 167). No differences between patients and controls were observed. However, locally skewed X-chromsome inactivation may exist in the thymus, and therefore the underlying hypothesis remains to be disproved.

Tags: autoimmune-diseases, nih, t-cell-tolerance, thymic-deletion, x-chromosome-inactivation
Organization: U.S. Department of Health & Human Services
Dependence, Abuse, and Treatment Tables (Standard Errors and P Values) - 5.1 to 5.56

These detailed tables present standard errors for totals and prevalence estimates of substance dependence/abuse and treatment need/receipt from the 2011 National Survey on Drug Use and Health (NSDUH). Substances examined include illicit drugs, marijuana, cocaine, heroin, hallucinogens, inhalants, and the nonmedical use of prescription-type pain relievers, tranquilizers, stimulants, and sedatives, and alcohol.Standard errors are provided by age group, gender, race/ethnicity, education level, employment status, and geographic area. Standard errors are provided for both 2011 and 2010.

Tags: nsduh-data, samhsa, standard-errors, substance-abuse, treatment-need
Organization: U.S. Department of Health & Human Services
Compound 527358: 18,22,26-Trimethyl-dotriacontyl cyanide

Chemical compound data from PubChem database. IUPAC Name: 19,23,27-trimethyltritriacontanenitrile. Molecular Formula: C36H71N. Molecular Weight: 518.0. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 528495: Heneicosane, 6-methyl

Chemical compound data from PubChem database. IUPAC Name: 6-methylhenicosane. Molecular Formula: C22H46. Molecular Weight: 310.6. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Table 1. Illicit Drug Use in the Past Month, by Age Group and State: Percentages, Annual Averages Based on 2013 and 2014 NSDUHs

Table 1. Illicit Drug Use in the Past Month, by Age Group and State: Percentages, Annual Averages Based on 2013 and 2014 NSDUHs

Tags: illicit-drug-use, nsduh-data, samhsa, state-level-data, substance-use
Organization: U.S. Department of Health & Human Services
Association of MHC and rheumatoid arthritis: Regulatory role of HLA class II molecules in animal models of RA - studies on transgenic/knockout mice

Human leucocyte antigen (HLA) class II molecules have been shown to be associated with predisposition to rheumatoid arthritis (RA). We generated HLA-DR and DQ transgenic mice that lacked endogenous class II molecules to study the interaction between the DR and DQ molecules and define the immunologic mechanisms in rheumatoid arthritis. Using collagen-induced arthritis (CIA) as an experimental model for inflammatory polyarthritis, we show that both DQ and DR are involved in predisposition or resistance to arthritis. Our studies suggest that polymorphism in DQB1 genes may determine predisposition to RA while the DRB1 polymorphism may dictate severity/protection of the disease. These mice provide powerful tools to develop immunotherapeutic protocols.

Tags: collagen-induced-arthritis, hla-class-ii, nih, rheumatoid-arthritis, transgenic-mice
Organization: U.S. Department of Health & Human Services
2011-2012 NSDUH State Estimates of Substance Use and Mental Disorders

State estimates for 25 measures of substance use and mental disorders based on the combined 2011 and 2012 National Surveys on Drug Use and Health (NSDUHs) are provided. Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Results are provided by State and for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older. State and regional estimates are based on a small area estimation (SAE) methodology in which State-level NSDUH data are combined with county and census block group/tract-level data from the State.

Tags: mental-disorders, samhsa, smi-ami-mde, state-estimates, substance-use
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: HHS Regions, 2014

These are behavioral health reports for each of the ten HHS regions of the United States. Each report utilizes data from the National Survey on Drug Use and Health (NSDUH), collected annually. The topics addressed in the reports include youth substance use, youth mental health and treatment, adult mental health and treatment, substance use and substance use and treatment

Tags: behavioral-health, mental-health, regional-data, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
ICUs worldwide: Results of a nationwide survey of Colombian intensive care units

Sixty-three of 89 identified intensive care units in Colombia (Evaluation of Intensive Care in Colombia) participated in this voluntary study. A convenience sample of 20 intensive care units, each submitting 200 patients or more, was chosen, from which the following information is presented. The Intensive Care National Audit and Research Center (UK) protocol was used to evaluate patient severity, length of stay, raw and anticipated mortality, intensive care unit patient admission/rejection criteria, and human and technologic resources available. Information was drawn from public and private institutions.

Tags: colombia-healthcare, icu-data, intensive-care, mortality-rate, nih
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Texas, 2014

This is a behavioral health report for the state of Texas. It uses the  National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment Services (NSSATS) to address the topics of youth substance use , youth mental health and treatment, adult mental health and treatment, substance use, substance use treatment, and medicare enrollees for the years 2009 to 2013.

Tags: mental-health-indicators, samhsa, substance-use-trends, texas-behavioral-health, youth-mental-health
Organization: U.S. Department of Health & Human Services
2010 State Profile — Nebraska

This state profile includes data from facilities in Nebraska that reported to N-SSATS for the survey reference date March 31, 2010. Data were collected on the location, characteristics, services offered, and number of clients in treatment at alcohol and drug abuse treatment facilities (both public and private) in Nebraska. In Nebraska, 115 substance abuse treatment facilities were included in the 2010 N-SSATS, reporting that there were 5,326 clients in substance abuse treatment on March 31, 2010. The survey response rate in Nebraska was 91.9%.

Tags: alcohol-abuse, n-ssats, nebraska, samhsa, substance-abuse-treatment
Organization: U.S. Department of Health & Human Services
Effectiveness of specific RNA-mediated interference through ingested double-stranded RNA in

RNAi can be achieved by feeding worms Escherichia coli expressing dousble-stranded RNA corresponding to a specific gene. An optimized feeding method is presented that results in phenotypes at least as strong as those produced by direct injection of RNA for embryonic lethal genes, and stronger for genes with post-embryonic phenotypes.

Tags: c-elegans, gene-expression, gene-silencing, nih, rna-interference
Organization: U.S. Department of Health & Human Services
2020 Uniform Reporting System (URS) Output Tables

These are the 2020 Uniform Reporting System (URS) Output Tables. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: evidence-based-practices, mental-health-services, national-outcome-measures, samhsa, state-mental-health
Organization: U.S. Department of Health & Human Services
National Directory of Drug and Alcohol Abuse Treatment Facilities - 2019

The National Directory of Drug and Alcohol Abuse Treatment Facilities - 2019 is a listing of federal, state, and local government facilities and private facilities that provide substance abuse treatment services. It includes treatment facilities that (1) are licensed, certified, or otherwise approved for inclusion in the Directory by their State Substance Abuse Agencies, and (2) responded to the 2018 National Survey of Substance Abuse Treatment Services (N-SSATS). The information about each facility that appears in this Directory was provided by that facility in response to the 2018 N-SSATS. N-SSATS is conducted annually by the Substance Abuse and Mental Health Services Administration (SAMHSA).The Directory is ordered alphabetically by state, by city within each state, and by facility name within each city. Each facility listing includes codes that represent the services offered and other features of the facility, including codes that indicate services for hearing impaired and non-English-speaking clients. Codes are defined in a key shown on pages v-ix. Because the services offered by a particular facility may change over time, it is always a good idea to verify the information in this Directory when contacting a facility.

Tags: alcohol-abuse-treatment, behavioral-health-services, samhsa, substance-abuse-treatment, treatment-facilities
Organization: U.S. Department of Health & Human Services