AndreaBozzo/ceres-open-data-index huggingface dataset:
Address-Based Sampling Research Report

If the Substance Abuse and Mental Health Services Administration (SAMHSA) is to move NSDUH to a hybrid ABS/field-enumerated frame, several questions will need to be answered, procedures will need to be developed and tested, and costs and benefits will need to be weighed. This report outlines what is known to date, how it may be applied to NSDUH, and what additional considerations need to be addressed.

Tags: address-based-sampling, mental-health-survey, nsduh-methodology, samhsa, substance-use-survey
Organization: U.S. Department of Health & Human Services
2022 Uniform Reporting System (URS) Table For Federated States of Micronesia

This is the 2022 Uniform Reporting System (URS) Output Tables for Federated States of Micronesia. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: mental-health-services, micronesia, national-outcome-measures, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
Serious Mental Health Challenges among Older Adolescents and Young Adults

This short report uses 2010 to 2012 National Survey on Drug Use and Health (NSDUH) to assess any mental illness/serious mental illness and treatment among those ages 18 to 25 and major depressive episodes and treatment among those aged 16 to 17. Results are shown by residential stability, employment, education, and health insurance coverage.

Tags: mental-health-treatment, nsduh-data, samhsa, serious-mental-illness, young-adults
Organization: U.S. Department of Health & Human Services
Publications Using SAMHSA DataNational Survey of Substance Abuse Treatment Services (N-SSATS): 2017, Data on Substance Abuse Treatment Facilities

This report presents results from the 2017 National Survey of Substance Abuse Treatment Services (N-SSATS), an annual census of facilities providing substance abuse treatment. Conducted by the Substance Abuse and Mental Health Services Administration (SAMHSA), N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 states, the District of Columbia, and other jurisdictions. It is important to note that values in charts, narrative lists, and percentage distributions are calculated using actual raw numbers and rounded for presentation in this report; calculations using rounded values may produce different results.

Tags: behavioral-health-services, n-ssats, samhsa, substance-abuse-treatment, treatment-facilities
Organization: U.S. Department of Health & Human Services
Compound 525401: Pentafluoropropionic acid, hexadecyl ester

Chemical compound data from PubChem database. IUPAC Name: hexadecyl 2,2,3,3,3-pentafluoropropanoate. Molecular Formula: C19H33F5O2. Molecular Weight: 388.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 525118: 3-Chloropropyl isopentanoate

Chemical compound data from PubChem database. IUPAC Name: 3-chloropropyl 3-methylbutanoate. Molecular Formula: C8H15ClO2. Molecular Weight: 178.65. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Child Maltreatment 2019

This report presents national data about child abuse and neglect known to child protective services agencies in the United States during federal fiscal year 2019.

Letter from the Associate Commissioner

Acknowledgements

30th Edition of Child Maltreatment

Summary

CHAPTER 1: Introduction

CHAPTER 2: Reports

CHAPTER 3: Children

CHAPTER 4: Fatalities

CHAPTER 5: Perpetrators

CHAPTER 6: Services

CHAPTER 7: Special Focus

APPENDIX A: CAPTA Data Items

APPENDIX B: Glossary

APPENDIX C: State Characteristics

APPENDIX D: State Commentary

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: abuse, assessment, fiscal, maltreatment, neglect
Organization: U.S. Department of Health & Human Services
Identification of candidate downstream genes for the homeodomain transcription factor Labial in

Background:
          Homeotic genes are key developmental regulators that are highly conserved throughout evolution. Their encoded homeoproteins function as transcription factors to control a wide range of developmental processes. Although much is known about homeodomain-DNA interactions, only a small number of genes acting downstream of homeoproteins have been identified. Here we use a functional genomic approach to identify candidate target genes of the Drosophila homeodomain transcription factor Labial.
        
        
          Results:
          High-density oligonucleotide arrays with probe sets representing 1,513 identified and sequenced genes were used to analyze differential gene expression following labial overexpression in Drosophila embryos. We find significant expression level changes for 96 genes belonging to all functional classes represented on the array. In accordance with our experimental procedure, we expect that these genes are either direct or indirect targets of labial gene action. Among these genes, 48 were upregulated and 48 were downregulated following labial overexpression. This corresponds to 6.3% of the genes represented on the array. For a selection of these genes, we show that the data obtained with the oligonucleotide arrays are consistent with data obtained using quantitative RT-PCR.
        
        
          Conclusions:
          Our results identify a number of novel candidate downstream target genes for Labial, suggesting that this homeoprotein differentially regulates a limited and distinct set of embryonically expressed Drosophila genes.

Tags: drosophila-embryos, gene-expression, homeotic-genes, nih, transcription-factors
Organization: U.S. Department of Health & Human Services
2015 CMHS Uniform Reporting System (URS) Table for Louisiana

2015 Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for Louisiana. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, national-outcome-measures, samhsa, substance-abuse-treatment
Organization: U.S. Department of Health & Human Services
Absence of rapid selection for acyclovir or penciclovir resistance following suboptimal oral prodrug therapy of HSV-infected mice

Background
          Acyclovir (ACV) resistant herpes simplex virus (HSV) isolates can be readily selected in animal infection models receiving suboptimal ACV treatment, however no comparative studies of the emergence of resistance following suboptimal treatment with valacyclovir (VCV) or famciclovir (FCV), the prodrugs of acyclovir and penciclovir, respectively, have been reported.
        
        
          Methods
          Mice (n = 30) were infected with HSV type 1 or 2 in the ear pinnae and administered oral prodrugs at one fifth a dose previously shown to be effective. To select and amplify drug-resistant HSV, a total of seven consecutive in vivo passages with suboptimal treatment were performed for each virus sample and progeny virus from each passage was characterized by the plaque reduction (PRA) and plating efficiency assays (PEA).
        
        
          Results
          No drug-resistant HSV-2 and only a single drug-resistant HSV-1 variant were identified. Virus recovered from the first three sequential passages of this HSV-1 sample was susceptible by PRA, although the proportion of resistant virus recovered gradually increased upon passage. The resistant HSV-1 phenotype was confirmed by PRA after four sequential passages in mice. Unexpectedly, this in vivo-selected drug-resistant HSV-1 failed to yield an infection completely refractory to treatment in subsequent passages.
        
        
          Conclusions
          Sub-optimal therapy of immunocompetent mice with either VCV or FCV did not readily select for HSV-mutants resistant to either ACV or PCV, suggesting that selection of resistance with either prodrug remains difficult using this system. Futhermore, this study suggests that the PEA may represent a useful adjunct to the PRA for monitoring alterations in the proportion of drug-resistant virus even when no change in IC50 is apparent.

Tags: acyclovir-resistance, antiviral-therapy, drug-resistance, hsv-infection, nih
Organization: U.S. Department of Health & Human Services
2016 Uniform Reporting System (URS) Table for Oregon

This is the 2016 Uniform Reporting System (URS) Output Tables for Oregon. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: mental-health-services, national-outcome-measures, oregon-urs-data, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
Nearly One Third of College Student Substance Abuse Treatment Admissions with Co-occurring Mental Disorders Abuse Prescription Drugs

This Data Spotlight from the Treatment Episode Data Set (TEDS) focuses on substance abuse treatment admissions during 2010 among college students who have co-occuring mental disorders.

Tags: co-occurring-disorders, college-students, prescription-drug-abuse, samhsa, substance-abuse-treatment
Organization: U.S. Department of Health & Human Services
2010 CMHS Uniform Reporting System (URS) Output Tables for Oklahoma

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2010. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, national-outcome-measures, samhsa, substance-abuse-mental-health
Organization: U.S. Department of Health & Human Services
Local and distant recurrences in rectal cancer patients are predicted by the nonspecific immune response; specific immune response has only a systemic effect - a histopathological and immunohistochemical study

Background
          Invasion and metastasis is a complex process governed by the interaction of genetically altered tumor cells and the immunological and inflammatory host reponse. Specific T-cells directed against tumor cells and the nonspecific inflammatory reaction due to tissue damage, cooperate against invasive tumor cells in order to prevent recurrences. Data concerning involvement of individual cell types are readily available but little is known about the coordinate interactions between both forms of immune response.
        
        
          Patients and methods
          The presence of inflammatory infiltrate and eosinophils was determined in 1530 patients with rectal adenocarcinoma from a multicenter trial. We selected 160 patients to analyze this inflammatory infiltrate in more detail using immunohistochemistry. The association with the development of local and distant relapses was determined using univariate and multivariate log rank testing.
        
        
          Results
          Patients with an extensive inflammatory infiltrate around the tumor had lower recurrence rates (3.4% versus 6.9%, p = 0.03), showing the importance of host response against tumor cells. In particular, peritumoral mast cells prevent local and distant recurrence (44% versus 15%, p = 0.007 and 86% versus 21%, p < 0.0001, respectively), with improved survival as a consequence. The presence of intratumoral T-cells had independent prognostic value for the occurrence of distant metastases (32% versus 76%, p < 0.0001).
        
        
          Conclusions
          We showed that next to properties of tumor cells, the amount and type of inflammation is also relevant in the control of rectal cancer. Knowledge of the factors involved may lead to new approaches in the management of rectal cancer.

Tags: immune-response, immunohistochemistry, nih, rectal-cancer, tumor-recurrence
Organization: U.S. Department of Health & Human Services
SNP frequency, haplotype structure and linkage disequilibrium in elite maize inbred lines

Background
          Recent studies of ancestral maize populations indicate that linkage disequilibrium tends to dissipate rapidly, sometimes within 100 bp. We set out to examine the linkage disequilibrium and diversity in maize elite inbred lines, which have been subject to population bottlenecks and intense selection by breeders. Such population events are expected to increase the amount of linkage disequilibrium, but reduce diversity. The results of this study will inform the design of genetic association studies.
        
        
          Results
          We examined the frequency and distribution of DNA polymorphisms at 18 maize genes in 36 maize inbreds, chosen to represent most of the genetic diversity in U.S. elite maize breeding pool. The frequency of nucleotide changes is high, on average one polymorphism per 31 bp in non-coding regions and 1 polymorphism per 124 bp in coding regions. Insertions and deletions are frequent in non-coding regions (1 per 85 bp), but rare in coding regions. A small number (2–8) of distinct and highly diverse haplotypes can be distinguished at all loci examined. Within genes, SNP loci comprising the haplotypes are in linkage disequilibrium with each other.
        
        
          Conclusions
          No decline of linkage disequilibrium within a few hundred base pairs was found in the elite maize germplasm. This finding, as well as the small number of haplotypes, relative to neutral expectation, is consistent with the effects of breeding-induced bottlenecks and selection on the elite germplasm pool. The genetic distance between haplotypes is large, indicative of an ancient gene pool and of possible interspecific hybridization events in maize ancestry.

Tags: haplotype-structure, linkage-disequilibrium, maize-inbred-lines, nih, snp-frequency
Organization: U.S. Department of Health & Human Services
Alterations of E-cadherin and β-catenin in gastric cancer

Background
          The E-cadherin-catenin complex plays a crucial role in epithelial cell-cell adhesion and in the maintenance of tissue architecture. Perturbation in the expression or function of this complex results in loss of intercellular adhesion, with possible consequent cell transformation and tumour progression.
        
        
          Methods
          We studied the alterations of E-cadherin and β-catenin in a set of 50 primary gastric tumours by using loss of heterozygosity (LOH) analysis, gene mutation screening, detection of aberrant transcripts and immunohistochemistry (IHC).
        
        
          Results
          A high frequency (75%) of LOH was detected at 16q22.1 containing E-cadherin locus. Three cases (6%) showed the identical missense mutation, A592T. This mutation is not likely to contribute strongly to the carcinogenesis of gastric cancer, because a low frequency (1.6%) of this mutation was also found in 187 normal individuals. We also detected a low frequency (0.36%, 0%) of this mutation in 280 breast tumours and 444 other tumours, including colon and rectum, lung, endometrium, ovary, testis, kidney, thyroid carcinomas and sarcomas, respectively. We also analyzed the aberrant E-cadherin mRNAs in the gastric tumours and found that 7 tumours (18%) had aberrant mRNAs in addition to the normal mRNA. These aberrant mRNAs may produce abnormal E-cadherin molecules, resulting in weak cell-cell adhesion and invasive behaviour of carcinoma cells. Reduced expression of E-cadherin and β-catenin was identified at the frequency of 42% and 28%, respectively. Specially, 11 tumours (22%) exhibited positive cytoplasmic staining for β-catenin IHC. An association was found between reduced expression of E-cadherin and β-catenin. Moreover, an association was detected between reduced expression of E-cadherin and diffuse histotype.
        
        
          Conclusion
          Our results support the hypothesis that alterations of E-cadherin and β-catenin play a role in the initiation and progression of gastric cancer.

Tags: beta-catenin, e-cadherin, gastric-cancer, loh-analysis, nih
Organization: U.S. Department of Health & Human Services
Neurotrophins in bronchial asthma

Allergic bronchial asthma (BA) is characterized by chronic airway inflammation, development of airway hyperreactivity and recurrent reversible airway obstruction. T-helper 2 cells and their products have been shown to play an important role in this process. In contrast, the mechanisms by which immune cells interact with the cells residing in lung and airways, such as neurons, epithelial or smooth muscle cells, still remains uncertain. Sensory and motor neurons innervating the lung exhibit a great degree of functional plasticity in BA defined as 'neuronal plasticity'. These neurons control development of airway hyperresponsiveness and acute inflammatory responses, resulting in the concept of 'neurogenic inflammation'. Such quantitative and/or qualitative changes in neuronal functions are mediated to a great extent by a family of cytokines, the neurotrophins, which in turn are produced by activated immune cells, among others in BA. We have therefore developed the concept that neurotrophins such as nerve growth factor and brain-derived neurotrophic factor link pathogenic events in BA to dysfunctions of the immune and nervous system.

Tags: airway-inflammation, bronchial-asthma, neuronal-plasticity, neurotrophins, nih
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: North Dakota, 2015

This is a behavioral health report for the state of North Dakota. The report utilizes data from the National Survey on Drug Use and Health (NSDUH), and the Uniform Reporting System. The topics addressed in the report include youth substance use, youth mental health and treatment, mental health and treatment, substance use and substance use treatment.

Tags: behavioral-health, north-dakota, samhsa, substance-use, youth-mental-health
Organization: U.S. Department of Health & Human Services
Compound 525384: 2,5-Dimethyl-4-thiaheptane

Chemical compound data from PubChem database. IUPAC Name: 2-(2-methylpropylsulfanyl)butane. Molecular Formula: C8H18S. Molecular Weight: 146.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2010 State Profile — Arkansas

This state profile includes data from facilities in Arkansas that reported to N-SSATS for the survey reference date March 31, 2010. Data were collected on the location, characteristics, services offered, and number of clients in treatment at alcohol and drug abuse treatment facilities (both public and private) in Arkansas. In Arkansas, 62 substance abuse treatment facilities were included in the 2010 N-SSATS, reporting that there were 3,936 clients in substance abuse treatment on March 31, 2010. The survey response rate in Arkansas was 98.5%.

Tags: alcohol-drug-abuse, arkansas, n-ssats, samhsa, substance-abuse-treatment
Organization: U.S. Department of Health & Human Services
2010 State Profile — United States

This state profile includes data from facilities in the United States that reported to N-SSATS for the survey reference date March 31, 2010. Data were collected on the location, characteristics, services offered, and number of clients in treatment at alcohol and drug abuse treatment facilities (both public and private) in the United States. In the United States, 13,339 substance abuse treatment facilities were included in the 2010 N-SSATS, reporting that there were 1,175,462 clients in substance abuse treatment on March 31, 2010. The survey response rate in the United States was 91.4%.

Tags: mental-health-services, n-ssats, samhsa, substance-abuse-treatment, treatment-facility-data
Organization: U.S. Department of Health & Human Services
2010-2012 NSDUH Substate Region Estimates Categorized into Seven Groups by Age Group

This table uses 2010 to 2012 National Survey on Drug Use and Health (NSDUH) to assess past year alcohol use disorder and illicit drug use disorder among persons aged 12 or older by 362 substate regions within the 50 States and the District of Columbia. Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). This report presents substate region estimates by age group differences. The scales in this report are a companion piece to the 2010-2012 National Surveys on Drug Use and Health: Substate Age Group Tables.

Tags: alcohol-use-disorder, mental-health-indicators, nsuh-survey, samhsa, substance-use-disorder
Organization: U.S. Department of Health & Human Services
Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists

Background
          The Hedgehog (Hh) signaling pathway is vital to animal development as it mediates the differentiation of multiple cell types during embryogenesis. In adults, Hh signaling can be activated to facilitate tissue maintenance and repair. Moreover, stimulation of the Hh pathway has shown therapeutic efficacy in models of neuropathy. The underlying mechanisms of Hh signal transduction remain obscure, however: little is known about the communication between the pathway suppressor Patched (Ptc), a multipass transmembrane protein that directly binds Hh, and the pathway activator Smoothened (Smo), a protein that is related to G-protein-coupled receptors and is capable of constitutive activation in the absence of Ptc.
        
        
          Results
          We have identified and characterized a synthetic non-peptidyl small molecule, Hh-Ag, that acts as an agonist of the Hh pathway. This Hh agonist promotes cell-type-specific proliferation and concentration-dependent differentiation in vitro, while in utero it rescues aspects of the Hh-signaling defect in Sonic hedgehog-null, but not Smo-null, mouse embryos. Biochemical studies with Hh-Ag, the Hh-signaling antagonist cyclopamine, and a novel Hh-signaling inhibitor Cur61414, reveal that the action of all these compounds is independent of Hh-protein ligand and of the Hh receptor Ptc, as each binds directly to Smo.
        
        
          Conclusions
          Smo can have its activity modulated directly by synthetic small molecules. These studies raise the possibility that Hh signaling may be regulated by endogenous small molecules in vivo and provide potent compounds with which to test the therapeutic value of activating the Hh-signaling pathway in the treatment of traumatic and chronic degenerative conditions.

Tags: hedgehog-signaling, nih, small-molecule-modulators, smoothened-agonists, smoothened-antagonists
Organization: U.S. Department of Health & Human Services