AndreaBozzo/ceres-open-data-index huggingface dataset:
Compound 527308: Methyl 2-[2-(2,6-dichloro-4-methoxyanilino)phenyl]acetate

Chemical compound data from PubChem database. IUPAC Name: methyl 2-[2-(2,6-dichloro-4-methoxyanilino)phenyl]acetate. Molecular Formula: C16H15Cl2NO3. Molecular Weight: 340.2. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Minneapolis: Drug-Related Emergency Department Visits, 2004-2011 - Suicide Attempts

Excel file with estimates, rates, relative standard errors, trends and confidence intervals for all drug-related emergency department (ED) visits involving suicide attempts in the Minneapolis metropolitan area, covering 2004-2011.  Drug-related suicide attempts include visits for drug overdoses and for suicide attempts by other means (e.g., using a firearm) if drugs were involved or related to the suicide attempt.

Tags: drug-overdose, emergency-department, minneapolis, samhsa, suicide-attempts
Organization: U.S. Department of Health & Human Services
2022 National Directory of Mental Health Treatment Facilities

TheNational Directory of Mental Health Treatment Facilities - 2022is a listing of federal, state, and local government facilities and private facilities that provide mental health treatment services. It includes treatment facilities that responded to the 2021 National Substance Use and Mental Health Services Survey (N-SUMHSS). The information about each facility that appears in this Directory was provided by that facility in response to the 2021 N-SUMHSS. The N-SUMHSS is conducted annually by the Substance Abuse and Mental Health Services Administration (SAMHSA). The 2022 Directory is available in PDF and Excel formats.The Directory is ordered alphabetically by state, by city within each state, and by facility name within each city. Each facility listing includes codes that represent the services offered and other features of the facility, including codes that indicate services for hearing impaired and non-English-speaking clients. Codes are defined in a key shown on pages v-ix of the PDF file and as a separate tab on the Excel version. Because the services offered by a particular facility may change over time, it is always a good idea to verify the information in this Directory when contacting a facility.

Tags: behavioral-health, facility-directory, mental-health-facilities, samhsa, treatment-services
Organization: U.S. Department of Health & Human Services
Compound 525538: Methyl 2-(4-isopropoxyphenyl)acetate

Chemical compound data from PubChem database. IUPAC Name: methyl 2-(4-propan-2-yloxyphenyl)acetate. Molecular Formula: C12H16O3. Molecular Weight: 208.25. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Tribal Federal Medical Assistance Percentage (FMAP)

The following resources provide information for tribes interested in operating title IV-E programs.

Tribal Federal Medical Assistance Percentage Look-Up Table for FY 2026Tribal Federal Medical Assistance Percentage Reference Table for FY 2026Tribal Federal Medical Assistance Percentage Look-Up Table for FY 2025Tribal Federal Medical Assistance Percentage Reference Table for FY 2025Tribal Federal Medical Assistance Percentage Look-Up Table for FY 2024Tribal Federal Medical Assistance Percentage Reference Table for FY 2024Tribal Federal Medical Assistance Percentage Look-Up Table for FY 2023Tribal Federal Medical Assistance Percentage Reference Table for FY 2023Tribal Federal Medical Assistance Percentage Look-Up Table for FY 2022Tribal Federal Medical Assistance Percentage Reference Table for FYs 2021-2022Tribal Federal Medical Assistance Percentage Look-Up Table for FY 2021Tribal Federal Medical Assistance Percentage Reference Table for FY 2021Tribal Federal Medical Assistance Percentage Look-Up Table for FY 2020Tribal Federal Medical Assistance Percentage Reference Table for FY 2020Tribal Federal Medical Assistance Percentage Look-Up Table for FY 2019Tribal Federal Medical Assistance Percentage Reference Table for FYs 2018-2019Tribal Federal Medical Assistance Percentage Look-Up Table for FY 2018Tribal Federal Medical Assistance Percentage Reference Table for FYs 2017-2018Tribal Federal Medical Assistance Percentage Look-Up Table for FY 2017Tribal Federal Medical Assistance Percentage Look-Up Table for FY 2016Tribal Federal Medical Assistance Percentage Reference Table for FYs 2016-2017Tribal Federal Medical Assistance Percentage Reference Table for FYs 2014-2015Tribal Federal Medical Assistance Percentage Reference Table for FYs 2013-2014

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: child, grant, health, policy, rat
Organization: U.S. Department of Health & Human Services
Lessons learned from gene transfer approaches

Recent technological advances allow the transfer of genes to the			 synovial lining of joints. As well as opening novel opportunities for therapy,			 these techniques provide valuable new tools for the study of synovitis and			 other aspects of the biology of joints in health and disease. This article			 reviews briefly the results of experiments in which selected genes have been			 transferred to the knee joints of healthy rabbits and rabbits with			 antigen-induced arthritis.

Tags: antigen-induced-arthritis, gene-transfer, nih, rabbit-model, synovitis
Organization: U.S. Department of Health & Human Services
Utah (UT)

This report presents Utah\'s estimates for 25 measures of substance use and mental health based on the combined 2009 and 2010 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for Utah for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: major-depression, mental-health, samhsa, substance-use, suicidal-ideation
Organization: U.S. Department of Health & Human Services
Patent AT-E401166-T1: [Translated] METHOD FOR CHECKING THE PLACEMENT OF MACHINE TOOLS AND THE PLACEMENT CHECKING DEVICE

The method involves monitoring whether an object is correctly arranged on a supporting surface in a machine tool and/or clamped by a device with first and second clamping arrangements using a line system carrying a medium and subject to pressure ending in the support surface and/or in the first clamping arrangement. The end opening of the line system is covered by the object and/or the second clamping arrangement, the pressure in the line system is reduced at a choke point, the pressure difference before and after the choke point is determined and evaluated for support control or clamping control. The cooling/lubricating liquid, an air-coolant mixture or the air-coolant flushing medium of a machine tool is used as the medium. Independent claims are also included for the following: (A) a device for object support control for a machine tool (B) and a machine tool, especially a cutting tool, with an inventive device.

Tags: chemistry, innovation, patent, pubchem, research
Organization: U.S. Department of Health & Human Services
Utilizing Title IV-E Funding to Support High-Quality Legal Representation and Promote Child and Family Well-Being

This Information Memorandum (IM) urges all state and tribal title IV-E agencies, courts, administrative offices of the courts, and Court Improvement Programs to work together to ensure that parents, children and youth, and child welfare agencies, receive high quality legal representation at all stages of child welfare proceedings, and to maximize allowable title IV-E administrative reimbursement for children who are candidates for title IV-E foster care or who are in title IV-E foster care and their parent(s) in foster care legal proceedings.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: child, fiscal, foster, guidance, policy
Organization: U.S. Department of Health & Human Services
2011 CMHS Uniform Reporting System (URS) Output Tables for California

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2011. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, national-outcome-measures, samhsa, urs-data
Organization: U.S. Department of Health & Human Services
Construction and high cytoplasmic expression of a tumoricidal single-chain antibody against hepatocellular carcinoma

Background
          Hep27 monoclonal (Hep27 Mab) is an antibody against hepatocellular carcinoma. Hep27 Mab itself can inhibit the growth of a hepatocellular carcinoma cell line (HCC-S102). We attempted to produce a single-chain fragment (scFv), a small fragment containing an antigen-binding site of Hep27 Mab, by using DNA-recombinant techniques.
        
        
          Results
          The sequences encoding the variable regions of heavy (VH) and light (VL) chains of a murine Hep27 Mab were linked together by a linker peptide (Gly4Ser)3 and tagged with a hexa-histidine at the C-terminal; the resultant DNA construct was expressed in E. coli as an insoluble protein. The denatured scFv was refolded and purified by immobilized metal ion affinity chromatography (12 mg/l with a molecular weight of 27 kDa). Hep27scFv exhibited a tumoricidal activity against the HCC-S102 cell as its parental antibody (Hep27 Mab).
        
        
          Conclusion
          This scFv may be a potential candidate for a targeting agent in HCC immunodiagnosis or immunotherapy.

Tags: hepatocellular-carcinoma, immunotherapy, nih, single-chain-antibody, tumor-targeting
Organization: U.S. Department of Health & Human Services
Compound 526387: 1,7-Dibromo,2,3-dichloro-dibenzo-dioxin

Chemical compound data from PubChem database. IUPAC Name: 1,7-dibromo-2,3-dichlorodibenzo-p-dioxin. Molecular Formula: C12H4Br2Cl2O2. Molecular Weight: 410.9. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 529617: Bis(trimethylsilyl) 2-[(trimethylsilyl)amino]succinate

Chemical compound data from PubChem database. IUPAC Name: bis(trimethylsilyl) 2-(trimethylsilylamino)butanedioate. Molecular Formula: C13H31NO4Si3. Molecular Weight: 349.64. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
The effect of EGTA and Ca

Background
          The Na/K-ATPase activity of the brain synaptic plasma membranes (SPM) is regulated by noradrenaline (NA) and the synaptosomal factor SF (soluble protein obtained from the synaptosome cytosol). In the absence of SF, NA inhibits Na/K-ATPase, while, on addition of SF to the reaction medium, there is a NA-dependent activation of Na/K-ATPase . On the other hand, EGTA augments the Na/K-ATPase activity and attenuates the ability of NA to inhibit Na/K-ATPase.
        
        
          Results
          Considering that Ca2+ ion is a Na/K-ATPase modifier, it can be assumed that the effect of NA and SF is a Ca2+-dependent process. However, in the presence of 0.3 mM EGTA and 0.1 mM NA, the apparent inhibition constant for Ca2+ (at [Ca2+] > 0.3 mM) is not SF dependent, while the apparent activation constant for SF does not change at increasing Ca2+ concentration ([Ca2+] < 0.3 mM). At various Ca2+ concentrations (0.06, 0.35 and 0.6 mM), no significant changes occur in the mode of action of NA on the Na/K-ATPase activity in the presence of 5 μg/ml SF. EGTA also has no effect on the NA-independent activation of Na/K-ATPase evoked by high SF concentrations.
        
        
          Conclusions
          Taking into account that in the absence of EGTA similar results have been obtained, it can be concluded that the effect of NA and SF on brain Na/K-ATPase is a Ca2+-independent process.

Tags: egta-calcium, na-k-atpase, nih, noradrenaline-effect, synaptic-membranes
Organization: U.S. Department of Health & Human Services
Compound 528843: Glycerol, 2,3-dimethyl, 1-hexadecanoate

Chemical compound data from PubChem database. IUPAC Name: 2,3-dimethoxypropyl hexadecanoate. Molecular Formula: C21H42O4. Molecular Weight: 358.6. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 529940: Dodecane, 6,7-dipropyl

Chemical compound data from PubChem database. IUPAC Name: 6,7-dipropyldodecane. Molecular Formula: C18H38. Molecular Weight: 254.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 528738: p-Octopamine, DTFMB-TMS

Chemical compound data from PubChem database. IUPAC Name: 3,5-bis(trifluoromethyl)-N-[2-trimethylsilyloxy-2-(4-trimethylsilyloxyphenyl)ethyl]benzamide. Molecular Formula: C23H29F6NO3Si2. Molecular Weight: 537.6. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Region 5, Volume 6

This is a behavioral health report for HHS Region V of the United States and utilizes data from the National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment (N-SSATS), collected annually. The topics addressed in the reports include youth mental health and treatment, adult mental health and treatment, and substance use treatment.

Tags: behavioral-health, mental-health-treatment, region-5, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: South Dakota, 2014

This is a behavioral health report for the state of South Dakota. It uses the  National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment Services (NSSATS) to address the topics of youth substance use , youth mental health and treatment, adult mental health and treatment, substance use, substance use treatment, and medicare enrollees for the years 2009 to 2013.

Tags: behavioral-health, mental-health, samhsa, south-dakota, substance-use
Organization: U.S. Department of Health & Human Services
Cell density related gene expression: SV40 large T antigen levels in immortalized astrocyte lines

Background
          Gene expression is affected by population density. Cell density is a potent negative regulator of cell cycle time during exponential growth. Here, we asked whether SV40 large T antigen (Tag) levels, driven by two different promoters, changed in a predictable and regular manner during exponential growth in clonal astrocyte cell lines, immortalized and dependent on Tag.
        
        
          Results
          Expression and cell cycle phase fractions were measured and correlated using flow cytometry. T antigen levels did not change or increased during exponential growth as a function of the G1 fraction and increasing cell density when Tag was transcribed from the Moloney Murine Leukemia virus (MoMuLV) long terminal repeat (LTR). When an Rb-binding mutant T antigen transcribed from the LTR was tested, levels decreased. When transcribed from the herpes thymidine kinase promoter, Tag levels decreased. The directions of change and the rates of change in Tag expression were unrelated to the average T antigen levels (i.e., the expression potential).
        
        
          Conclusions
          These data show that Tag expression potential in these lines varies depending on the vector and clonal variation, but that the observed level depends on cell density and cell cycle transit time. The hypothetical terms, expression at zero cell density and expression at minimum G1 phase fraction, were introduced to simplify measures of expression potential.

Tags: astrocyte-lines, cell-density, gene-expression, nih, sv40-t-antigen
Organization: U.S. Department of Health & Human Services
Autoantibody systems in rheumatoid arthritis: specificity, sensitivity and diagnostic value

The diagnosis of rheumatoid arthritis (RA) is primarily based on clinical symptoms, so it is often difficult to diagnose RA in very early stages of the disease. A disease-specific autoantibody that could be used as a serological marker would therefore be very useful. Most autoimmune diseases are characterized by a polyclonal B-cell response targeting multiple autoantigens. These immune responses are often not specific for a single disease. In this review, the most important autoantibody/autoantigen systems associated with RA are described and their utility as a diagnostic and prognostic tool, including their specificity, sensitivity and practical application, is discussed. We conclude that, at present, the antibody response directed to citrullinated antigens has the most valuable diagnostic and prognostic potential for RA.

Tags: autoantibodies, citrullinated-antigens, diagnostic-marker, nih, rheumatoid-arthritis
Organization: U.S. Department of Health & Human Services
Patent AT-E399838-T1: [Translated] PHOSPHATE FLUORTENSIDE FOR USE IN CARBON DIOXIDE

A method of removing water from a composition of matter comprises contacting a first composition of matter comprising water with a second composition of matter comprising: (1) at least one surfactant comprising at least one phosphate group and (2) a solvent comprising carbon dioxide, wherein at least a portion of the surfactant is soluble in the solvent, such that the at least one surfactant removes at least a portion of the water from the first composition.

Tags: chemistry, innovation, patent, pubchem, research
Organization: U.S. Department of Health & Human Services
Compound 528623: Pentanamide, N-isopropyl

Chemical compound data from PubChem database. IUPAC Name: N-propan-2-ylpentanamide. Molecular Formula: C8H17NO. Molecular Weight: 143.23. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2017 Uniform Reporting System (URS) Table for Northern Mariana Islands

This is the 2017 Uniform Reporting System (URS) Output Tables for Northern Mariana Islands. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-data, mental-health-services, noms-measures, northern-mariana-islands, samhsa
Organization: U.S. Department of Health & Human Services
Compound 527649: Hexyl 4-chlorobutanoate

Chemical compound data from PubChem database. IUPAC Name: hexyl 4-chlorobutanoate. Molecular Formula: C10H19ClO2. Molecular Weight: 206.71. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Compound 525650: N,N-Dimethyl-N'-propyl-p-chlorobenzamidine

Chemical compound data from PubChem database. IUPAC Name: 4-chloro-N,N-dimethyl-N'-propylbenzenecarboximidamide. Molecular Formula: C12H17ClN2. Molecular Weight: 224.73. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
AFCARS 2.1 Questions and Answers

Children's Bureau shared our current thinking on the answers to some of the questions submitted by title IV-E agencies. The webinar included questions and answers about the new data elements, so that the Children’s Bureau may develop relevant technical assistance resources.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: data, guidance, policy, real, reporting
Organization: U.S. Department of Health & Human Services
Pervasive influence of large-scale climate in the dynamics of a terrestrial vertebrate community

Background
          Large-scale climatic variability has been implicated in the population dynamics of many vertebrates throughout the Northern Hemisphere, but has not been demonstrated to directly influence dynamics at multiple trophic levels of any single system. Using data from Isle Royale, USA, comprising time series on the long-term dynamics at three trophic levels (wolves, moose, and balsam fir), we analyzed the relative contributions of density dependence, inter-specific interactions, and climate to the dynamics of each level of the community.
        
        
          Results
          Despite differences in dynamic complexity among the predator, herbivore, and vegetation levels, large-scale climatic variability influenced dynamics directly at all three levels. The strength of the climatic influence on dynamics was, however, strongest at the top and bottom trophic levels, where density dependence was weakest.
        
        
          Conclusions
          Because of the conflicting influences of environmental variability and intrinsic processes on population stability, a direct influence of climate on the dynamics at all three levels suggests that climate change may alter stability of this community. Theoretical considerations suggest that if it does, such alteration is most likely to result from changes in stability at the top or bottom trophic levels, where the influence of climate was strongest.

Tags: climate-impact, moose-population, nih, trophic-levels, wolf-population
Organization: U.S. Department of Health & Human Services
2014 CMHS Uniform Reporting System (URS) Table for Kansas

2014 Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for Kansas. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-program, community-mental-health, mental-health-services, outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services