AndreaBozzo/ceres-open-data-index huggingface dataset:
2010 State Profile — Florida

This state profile includes data from facilities in Florida that reported to N-SSATS for the survey reference date March 31, 2010. Data were collected on the location, characteristics, services offered, and number of clients in treatment at alcohol and drug abuse treatment facilities (both public and private) in Florida. In Florida, 593 substance abuse treatment facilities were included in the 2010 N-SSATS, reporting that there were 49,002 clients in substance abuse treatment on March 31, 2010. The survey response rate in Florida was 86.9%.

Tags: addiction-services, florida, n-ssats, samhsa, substance-abuse-treatment
Organization: U.S. Department of Health & Human Services
Thyroxine signal transduction in liver cells involves phospholipase C and phospholipase D activation. Genomic independent action of thyroid hormone

Background
          Numerous investigations demonstrate a novel role of thyroid hormone as a modulator of signal transduction. Protein kinase C (PKC) is critical to the mechanism by which thyroid hormones potentiate both the antiviral and immunomodulatory actions of IFNγ in different cells and regulate the exchange of signalling phospholipids in hepatocytes. Because nothing is known about accumulation of PKC modulator - diacylglycerol in cells treated with T4, we examined the nongenomic effect of thyroid hormones on DAG formation and phospholipase activation in liver cells.
        
        
          Results
          The results obtained provide the first demonstration of phospholipase C, phospholipase D and protein kinase C nongenomic activation and diacylglycerol (DAG) accumulation by L-T4 in liver cells. The experiments were performed in either the [14C]CH3COOH-labeled rat liver slices or isolated hepatocytes pre-labeled by [14C]oleic acid. L-T4 activates the DAG production in a concentration- and time-dependent manner. DAG formation in stimulated cells is biphasic and short-lived event: there is an initial, rapid rise in DAG concentration and then a slower accumulation that can be sustained for a few minutes. The early phase of L-T4 generated DAG only is accompanied by phosphatidylinositol 4,5-bisphosphate level decrease and inositol 1,4,5-trisphosphate formation while the second phase is abolished by PKC inhibitor l,(5-isoquinolinesulphonyl)2methylpiperasine dihydrochloride (H7) and propranolol. The second phase of DAG production is accompanied by free choline release, phosphatidylcholine content drop and phosphatidylethanol (Peth) formation. Inhibitor of phospholipase-C-dependent phosphoinositide hydrolysis, neomycin sulfate, reduced the Peth as well as the DAG response to L-T4.
        
        
          Conclusions
          The present data have indicated the DAG signaling in thyroid hormone-stimulated liver cells. L-thyroxine activates a dual phospholipase pathway in a sequential and synchronized manner: phospholipase C initiates the DAG formation, and PKC mediates the integration of phospholipase D into the signaling response during the sustained phase of agonist stimulation.

Tags: liver-cells, nih, phospholipase-c, phospholipase-d, thyroid-hormone
Organization: U.S. Department of Health & Human Services
Montana (MT)

This report presents estimates for measures of substance use and mental health based on the combined 2010 and 2011 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for Montana for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: mental-health, montana-behavioral-health, nsduh-data, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
3.4 Clients under age 18 in treatment by type of care received, and clients under age 18 in treatment in facilities offering special programs or groups for adolescents: 2007-2011.Number and percent distribution

This a National Survey of Substance Abuse Treatment Services (N-SSATS) data table showing clients under age 18 in treatment by type of care received, and clients under age 18 in treatment in facilities offering special programs or groups for adolescents from 2007 to 2011.

Tags: adolescent-substance-abuse, n-ssats, samhsa, substance-abuse-treatment, youth-treatment-programs
Organization: U.S. Department of Health & Human Services
Molecular genetics and structural genomics of the human protein kinase C gene module

Background
          Protein kinase C (PKC) has become a major focus among cell biologists interested in second-messenger signal transduction and much has been learned about differences in the cellular localization and function of its different isotypes. In this study we systematically address the genomic locations and gene structures of the human PKC gene module.
        
        
          Results
          We first carried out fine chromosomal mapping of all nine PKC genes by fluorescence in situ hybridization (FISH), using cosmid and BAC probes. The PKC genes are found to be dispersed throughout the genome, and in some positions distinct from those previously reported: PKCα is at 17q24, PKCβ at 16p12, PKCγ at 19q13.4, PKCδ at 3p21.2, PKCε at 2p21, PKCζ at 1p36.3, PKCη at 14q22-23, PKCθ at 10p15 and PKCι at 3q26. For PKCι, an additional FISH signal mapped on Xq21.3 revealed a pseudogene (derived by retrotransposition). PKCγ, ζ, and θ are found to map to the most distal positions on the chromosomes, potentially implicating telomere position effects in their expression. Using the complete human genome draft sequence and bioinformatics tools, we then carried out a systematic analysis of PKC gene structure, including determination of the occurrence of single-nucleotide polymorphisms corresponding to the PKC loci.
        
        
          Conclusion
          This resource of genomic information now facilitates investigation of the PKC gene module in structural chromosomal abnormalities and human disease locus mapping studies.

Tags: gene-mapping, nih, protein-kinase-c, signal-transduction, structural-genomics
Organization: U.S. Department of Health & Human Services
Auto-protective redox buffering systems in stimulated macrophages

Background
          Macrophages, upon encounter with micro-organisms or stimulated by cytokines, produce various effector molecules aimed at destroying the foreign agents and protecting the organism. Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are front line molecules exerting strong cytotoxic activities against micro-organisms and many cells, including macrophages themselves. Using cells of the murine macrophage cell line (RAW 264.7) stimulated in vitro with lipopolysaccharide (LPS) and/or interferon (IFN-γ), which induce strong endogenous NO production, we examined by which mechanisms a fraction of activated macrophages protect themselves from nitrosative stress and manage to escape destruction?
        
        
          Results
          We observed that survivors (10–50% depending on the experiments) had acquired a resistant phenotype being capable to survive when further exposed in vitro to an apoptosis inducing dose of the NO donor compound DETA-NO. These cells expressed an increased steady-state levels of Mn SOD, CuZn SOD and catalase mRNA (130–200%), together with an increased activity of the corresponding enzymes. Intracellular concentration of glutathione was also increased (× 3.5 fold at 6 hours, still maintained × 5.2 fold at 48 hours). Neither mRNA for glutathione peroxydase, γ-glutamylcysteine synthase and glutathione reductase, nor thioredoxine and thioredoxine reductase, were significantly modified. Additional experiments in which RAW 264.7 cells were stimulated with LPS and/or IFN-γ in the presence of relatively specific inhibitors of both Mn and Cu/Zn SOD, aminotriazol (ATZ) catalase inhibitor and buthionine sulfoximine (BSO) glutathione inhibitor, showed that inhibiting LPS-induced up-regulation of intracellular redox buffering systems also prevented acquisition of the resistant phenotype.
        
        
          Conclusions
          Our data suggest a direct causal relationship between survival of a fraction of macrophages and a up-regulation of key sets of auto-protective intracellular redox buffering systems, occurring simultaneously with modulation of expression of apoptotic molecules of the Bcl2-Bcl-XL/Bax-Bad family.

Tags: lps-stimulation, macrophage-activation, nih, nitrosative-stress, redox-buffering
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: New Hampshire, 2014

This is a behavioral health report for the state of New Hampshire. It uses the  National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment Services (NSSATS) to address the topics of youth substance use , youth mental health and treatment, adult mental health and treatment, substance use, substance use treatment, and medicare enrollees for the years 2009 to 2013.

Tags: behavioral-health, mental-health, new-hampshire, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
2011 NSSATS - Data on Substance Abuse Treatment Facilities

This report presents results from the 2011 National Survey of Substance Abuse Treatment Services (N-SSATS), an annual census of facilities providing substance abuse treatment. Conducted by the Substance Abuse and Mental Health Services Administration (SAMHSA), N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 States, the District of Columbia, Guam, Puerto Rico, Virgin Islands, and Republic of Palau.

Tags: behavioral-health-services, n-ssats, samhsa, substance-abuse-treatment, treatment-facilities
Organization: U.S. Department of Health & Human Services
NSDUH 2017 Data Collection Final Report

This report addresses the following topics relating to data collection for the 2017 NSDUH: Sampling and Counting and Listing Operations, Data Collection Staffing, Preparation of Survey Materials, Field Staff Training, Data Collection, Data Collection Results, and Quality Control.

Tags: data-collection-methods, nsduh-data, quality-control, samhsa, survey-methodology
Organization: U.S. Department of Health & Human Services
Extracting biological information from DNA arrays: an unexpected link between arginine and methionine metabolism in

Background
          In global gene expression profiling experiments, variation in the expression of genes of interest can often be hidden by general noise. To determine how biologically significant variation can be distinguished under such conditions we have analyzed the differences in gene expression when Bacillus subtilis is grown either on methionine or on methylthioribose as sulfur source.
        
        
          Results
          An unexpected link between arginine metabolism and sulfur metabolism was discovered, enabling us to identify a high-affinity arginine transport system encoded by the yqiXYZ genes. In addition, we tentatively identified a methionine/methionine sulfoxide transport system which is encoded by the operon ytmIJKLMhisP and is presumably used in the degradation of methionine sulfoxide to methane sulfonate for sulfur recycling. Experimental parameters resulting in systematic biases in gene expression were also uncovered. In particular, we found that the late competence operons comE, comF and comG were associated with subtle variations in growth conditions.
        
        
          Conclusions
          Using variance analysis it is possible to distinguish between systematic biases and relevant gene-expression variation in transcriptome experiments. Co-variation of metabolic gene expression pathways was thus uncovered linking nitrogen and sulfur metabolism in B. subtilis.

Tags: arginine-metabolism, bacillus-subtilis, gene-expression, methionine-metabolism, nih
Organization: U.S. Department of Health & Human Services
Oral contraceptive use before first birth and risk of breast cancer: a case control study

Background
          The aim of this study was first, to investigate whether women starting oral contraceptive (OC) use at a young age and before first birth have an increased risk for breast cancer and second, to report difficulties encountered in studying long-term health impacts of medical technologies.
        
        
          Methods
          Breast cancers occurring up until 1997 among 37153 Helsinki students born between 1946 and 1960 were identified by record linkage from the Finnish Cancer Registry; for each cancer case, five age-matched random controls were picked from the same student population. Those who had used the Helsinki Student Health Service (HSHS) at least three times (150 cases and 316 controls) form the final study subjects. Data on OC use and background characteristics were collected from patient records, and data on live births were derived from the population register. Odds ratios (OR) were adjusted for number of births, smoking and sports activity.
        
        
          Results
          Compared to the few non-users, OC users had a higher risk of breast cancer: the adjusted OR was 2.1 (95% confidence interval 1.1–4.2). Among OC users, no statistically significant differences in risk of breast cancer were found in regard to starting age or first birth, but small numbers made confidence intervals wide. Even though we had chosen students to be our study group, the population turned out to be unsuitable to answer our research question: most women had started their OC use old (at the age of 20 or later) and there were very few unexposed (almost all had used OC and before their first birth).
        
        
          Conclusions
          Because adoption of the modern pattern of OC use was not common among students, it is unlikely that the impact of early and extended OC use can be studied before 2010, when women born in the 1960s are 40 to 50 years old.

Tags: breast-cancer-risk, case-control-study, nih, oral-contraceptives, reproductive-health
Organization: U.S. Department of Health & Human Services
In 2012, 57 Percent of Substance Abuse Treatment Facilities Provided Community Outreach - Up from 47 Percent in 2006

This is a National Survey of Substance Abuse Treatment Services (N-SSATS)  spotlight showing the percent of substance abuse treatment facilities provided community outreach in 2012 compared to 2006. The National Survey of Substance Abuse Treatment Services (N-SSATS) is an annual survey designed to collect information from all facilities in the United States, both public and private, that provide substance abuse treatment.

Tags: community-outreach, samhsa, substance-abuse-treatment, survey, treatment-facilities
Organization: U.S. Department of Health & Human Services
Phorbol esters and CAMP differentially regulate the expression of CD4 and CD8 in human thymocytes

Background
          Intrathymic development and selection of the T lymphocyte repertoire is restricted by the interactions of the T cell antigen receptor and CD4 or CD8 co-receptors with self major histocompatibility complex molecules. Positive or negative selection depends on a tight regulatory control of CD4 and CD8 expression. Determining the intracellular signals that differentially regulate the expression of CD4 and CD8 is important to understand the mechanisms that are implicated in selection of single positive CD4+CD8- or CD4-CD8+.
        
        
          Results
          The present study shows that stimulation of human thymocytes by phorbol esters or cAMP result in a differential regulation of CD4 and CD8 expression, both at the mRNA and cell surface glycoprotein level.
        
        
          Conclusions
          The differential regulation of CD4 and CD8 gene expression suggests that the selective activation of protein kinase C (PKC) and cAMP-dependent protein kinases (PKA) may be required for the selection of single positive CD4+CD8- and CD4-CD8+ cells during Intrathymic differentiation

Tags: camp-regulation, cd4-cd8-expression, human-thymocytes, nih, phorbol-esters
Organization: U.S. Department of Health & Human Services
2019 Uniform Reporting System (URS) Table for North Dakota

These are the 2019 Uniform Reporting System (URS) Output Tables for North Dakota. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-data, mental-health-services, noms-measures, north-dakota, samhsa
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: Nevada, 2015

This is a behavioral health report for the state of Nevada. The report utilizes data from the National Survey on Drug Use and Health (NSDUH), and the Uniform Reporting System. The topics addressed in the report include youth substance use, youth mental health and treatment, mental health and treatment, substance use and substance use treatment.

Tags: mental-health-treatment, nevada-behavioral-health, nsduh-data, samhsa, youth-substance-use
Organization: U.S. Department of Health & Human Services
Compound 528375: 1,2,4-Trihydroxymenthane

Chemical compound data from PubChem database. IUPAC Name: 1-methyl-4-propan-2-ylcyclohexane-1,2,4-triol. Molecular Formula: C10H20O3. Molecular Weight: 188.26. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2016 National Directory of Mental Health Treatment Facilities

This publication is a National Directory of Mental Health Treatment Facilities for 2016. This directory is a listing of Federal, State, and local government facilities and private facilities that provide mental health treatment services. It includes treatment facilities that responded to the 2015 National Mental Health Services Survey (N-MHSS). The information about each facility that appears in this Directory was provided by that facility in response to the 2015 N-MHSS. The N-MHSS is conducted annually by the Substance Abuse and Mental Health Services Administration (SAMHSA). The Directory is ordered alphabetically by State, by city within each State, and by facility name within each city. This Directory include mental health treatment facilities for all U.S. states and territories.

Tags: facility-directory, mental-health, mental-health-facilities, samhsa, treatment-services
Organization: U.S. Department of Health & Human Services
Assessing the contribution of the herpes simplex virus DNA polymerase to spontaneous mutations

Background
          The thymidine kinase (tk) mutagenesis assay is often utilized to determine the frequency of herpes simplex virus (HSV) replication-mediated mutations. Using this assay, clinical and laboratory HSV-2 isolates were shown to have a 10- to 80-fold higher frequency of spontaneous mutations compared to HSV-1.
        
        
          Methods
          A panel of HSV-1 and HSV-2, along with polymerase-recombinant viruses expressing type 2 polymerase (Pol) within a type 1 genome, were evaluated using the tk and non-HSV DNA mutagenesis assays to measure HSV replication-dependent errors and determine whether the higher mutation frequency of HSV-2 is a distinct property of type 2 polymerases.
        
        
          Results
          Although HSV-2 have mutation frequencies higher than HSV-1 in the tk assay, these errors are assay-specific. In fact, wild type HSV-1 and the antimutator HSV-1 PAAr5 exhibited a 2–4 fold higher frequency than HSV-2 in the non-HSV DNA mutatagenesis assay. Furthermore, regardless of assay, HSV-1 recombinants expressing HSV-2 Pol had error rates similar to HSV-1, whereas the high mutator virus, HSV-2 6757, consistently showed signficant errors. Additionally, plasmid DNA containing the HSV-2 tk gene, but not type 1 tk or LacZ DNA, was shown to form an anisomorphic DNA stucture.
        
        
          Conclusions
          This study suggests that the Pol is not solely responsible for the virus-type specific differences in mutation frequency. Accordingly, it is possible that (a) mutations may be modulated by other viral polypeptides cooperating with Pol, and (b) the localized secondary structure of the viral genome may partially account for the apparently enhanced error frequency of HSV-2.

Tags: dna-polymerase, herpes-simplex-virus, mutation-frequency, nih, thymidine-kinase-assay
Organization: U.S. Department of Health & Human Services
The NSDUH Report: Revised Estimates of Mental Illness from the National Survey on Drug Use and Health

This report discusses improvements to the methods used to produce National Survey on Drug Use and Health (NSDUH) estimates of mental illness and provides revised 2011 mental illness estimates. The 2011 NSDUH rates of serious mental illness and any mental illness rates are shown by age group and gender subgroups

Tags: age-gender-analysis, mental-illness-estimates, nsduh-mental-health, samhsa, serious-mental-illness
Organization: U.S. Department of Health & Human Services
Tribal Consultation Meetings Regarding Requirements Applicable to  Title IV-B Child and Family Services Plan (Volume 77, Number 34)

Tribal Consultation Meetings Regarding Requirements Applicable to Title IV-B Child and Family Services Plan
  
  

 - This notice from the Federal Register requests comments from Indian tribes that operate a title IV-B, subpart 1 and/or title IV-B, subpart 2 program or any other interested party about possible revisions to the title IV-B regulations regarding the title IV-B plan and fiscal requirements.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: child, compliance, family, fiscal, policy
Organization: U.S. Department of Health & Human Services
Age-dependent changes in 24-hour rhythms of catecholamine content and turnover in hypothalamus, corpus striatum and pituitary gland of rats injected with Freund's adjuvant

Background
          Little information is available on the circadian sequela of an immune challenge in the brain of aged rats. To assess them, we studied 24-hour rhythms in hypothalamic and striatal norepinephrine (NE) content, hypothalamic and striatal dopamine (DA) turnover and hypophysial NE and DA content, in young (2 months) and aged (18–20 months) rats killed at 6 different time intervals, on day 18th after Freund's adjuvant or adjuvant's vehicle administration.
        
        
          Results
          Aging decreased anterior and medial hypothalamic NE content, medial and posterior hypothalamic DA turnover, and striatal NE concentration and DA turnover. Aging also decreased NE and DA content in pituitary neurointermediate lobe and augmented DA content in the anterior pituitary lobe. Immunization by Freund's adjuvant injection caused: (i) reduction of DA turnover in anterior hypothalamus and corpus striatum; (ii) acrophase delay of medial hypothalamic DA turnover in old rats, and of striatal NE content in young rats; (iii) abolition of 24-h rhythm in NE and DA content of neurointermediate pituitary lobe, and in DA content of anterior lobe, of old rats.
        
        
          Conclusions
          The decline in catecholamine neurotransmission with aging could contribute to the decrease of gonadotropin and increase of prolactin release reported in similar groups of rats. Some circadian responses to immunization, e.g. suppression of 24-h rhythms of neurointermediate lobe NE and DA and of anterior lobe DA were seen only in aged rats.

Tags: catecholamine-levels, circadian-rhythms, freunds-adjuvant, nih, rat-model
Organization: U.S. Department of Health & Human Services