AndreaBozzo/ceres-open-data-index huggingface dataset:
Recovery Services Provided by Substance Abuse Treatment Facilities in the United States

This is a National Survey of Substance Abuse Treatment Services (N-SSATS)  short report showing types of recovery services provided by substance abuse treatment facilities in the United States in 2012. The National Survey of Substance Abuse Treatment Services (N-SSATS) is an annual survey designed to collect information from all facilities in the United States, both public and private, that provide substance abuse treatment.

Tags: n-ssats, recovery-services, samhsa, substance-abuse-treatment, treatment-facilities
Organization: U.S. Department of Health & Human Services
Comparison of 2002-2003 and 2009-2010 prevalence estimates for persons aged 12 or older, 12 to 17, 18 to 25, and 26 or older; also for persons 12 to 20 for two alcohol measures.

This report presents trends of estimates for measures of substance use and mental health based on the combined 2002 and 2003 and the combined 2009 and 2010 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: mental-health, national-survey, prevalence-estimates, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Merging Auxiliary Data with NSDUH Data for Mental Health Research

This report describes the analytic potential of merging NSDUH data with auxiliary data (Section 2), potential sources of auxiliary data (Section 3), considerations when merging NSDUH data with auxiliary data sources (Section 4), and statistical considerations when using merged data (Section 5). Section 6 summarizes how to access restricted-use NSDUH data.

Tags: auxiliary-data, data-merging, mental-health-research, nsduh-data, samhsa
Organization: U.S. Department of Health & Human Services
A simple method for statistical analysis of intensity differences in microarray-derived gene expression data

Background
          Microarray experiments offer a potent solution to the problem of making and comparing large numbers of gene expression measurements either in different cell types or in the same cell type under different conditions. Inferences about the biological relevance of observed changes in expression depend on the statistical significance of the changes. In lieu of many replicates with which to determine accurate intensity means and variances, reliable estimates of statistical significance remain problematic. Without such estimates, overly conservative choices for significance must be enforced.
        
        
          Results
          A simple statistical method for estimating variances from microarray control data which does not require multiple replicates is presented. Comparison of datasets from two commercial entities using this difference-averaging method demonstrates that the standard deviation of the signal scales at a level intermediate between the signal intensity and its square root. Application of the method to a dataset related to the β-catenin pathway yields a larger number of biologically reasonable genes whose expression is altered than the ratio method.
        
        
          Conclusions
          The difference-averaging method enables determination of variances as a function of signal intensities by averaging over the entire dataset. The method also provides a platform-independent view of important statistical properties of microarray data.

Tags: gene-expression, intensity-differences, microarray-data, nih, statistical-analysis
Organization: U.S. Department of Health & Human Services
Midwest (MW)

This report presents the Midwest\'s (e.g., combines Illinois, Indiana, Iowa, Kansas, Michigan, Minnesota, Missouri, Nebraska, North Dakota, Ohio, South Dakota, and Wisconsin) estimates for 25 measures of substance use and mental health based on the combined 2009 and 2010 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for the Midwest for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: mental-health, nsduh-data, samhsa, serious-mental-illness, substance-use
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: HHS Region X, 2014

This is a behavioral health report for HHS Region X of the United States and utilizes data from the National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment (N-SSATS), collected annually. The topics addressed in the reports include youth substance use, youth mental health, adult mental health, and substance use treatment.

Tags: behavioral-health, hhs-region-x, mental-health, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Publications Using SAMHSA DataTrend Tables (Prevalence Estimates) - 7.1 to 7.45

These detailed tables show trends in population totals and prevalence estimates of illicit drug use, risk and protective factors, substance initiation, substance dependence/abuse, and need/receipt of substance use treatment from the 2012 National Survey on Drug Use and Health (NSDUH). Substances examined include illicit drugs (e.g., marijuana, cocaine, heroin, hallucinogens (including LSD, PCP, Ecstasy, Ketamine, DMT/AMT/Foxy, Salvia divinorum), inhalants, and the nonmedical use of prescription-type pain relievers (including OxyContin), tranquilizers, stimulants (Adderall) , sedatives (GHB, Ambien), non-prescription cold medicine, alcohol, and tobacco products (including cigarettes, smokeless tobacco, cigars, pipes). Results are provided for lifetime, past year, and past month use by age group, gender, race/ethnicity, education level, employment status, and geographic area. Comparisons are made between 2012 and 2002 through 2011.

Tags: drug-use-prevalence, mental-health-services, nsduh-data, samhsa, substance-use-trends
Organization: U.S. Department of Health & Human Services
Impact of the DSM-IV to DSM-5 Changes on the National Survey on Drug Use and Health

This report discusses how the change from APA\'s  Diagnostic and Statistical Manual of Mental Disorders (DSM) version IV to version 5 will impact NSDUH questionnaire items and estimates, specifically substance use disorders (SUDs), any mental illness (AMI), and serious mental illness (SMI).

Tags: dsm-5-impact, mental-illness-prevalence, nsduh-survey, samhsa, substance-use-disorders
Organization: U.S. Department of Health & Human Services
NSDUH 2019 Data Collection Final Report

This report describes tasks relating to data collection for the 2019 NSDUH: Sampling and Counting and Listing Operations, Data Collection Staffing, Preparation of Survey Materials, Field Staff Training, Data Collection, Data Collection Results, and Quality Control.

Tags: data-collection-methods, nsduh-2019, quality-control-procedures, samhsa, sampling-methodology
Organization: U.S. Department of Health & Human Services
2010 CMHS Uniform Reporting System (URS) Output Tables for Virgin Islands

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2010. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, outcome-measures, samhsa, virgin-islands
Organization: U.S. Department of Health & Human Services
Compound 527220: 1,2,3,4,4a,5,6,8a-Octahydro-1,4a-dimethyl-7-(1-methylethyl)-1-naphthalenol

Chemical compound data from PubChem database. IUPAC Name: 1,4a-dimethyl-7-propan-2-yl-2,3,4,5,6,8a-hexahydronaphthalen-1-ol. Molecular Formula: C15H26O. Molecular Weight: 222.37. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Research Article: BMC Microbiology

Background
          The acetamidase of Mycobacterium smegmatis is a highly inducible enzyme. Expression of this enzyme is increased 100-fold when the substrate acetamide is present. The acetamidase gene is found immediately downstream of three open reading frames. Two of these are proposed to be involved in regulation.
        
        
          Results
          We constructed a deletion mutant in one of the upstream ORFs (amiA). This mutant (Mad1) showed a constitutively high level of acetamidase expression. We identified four promoters in the upstream region using a β-galactosidase reporter gene. One of these (P2) was inducible in the wild-type, but was constitutively active in Mad1.
        
        
          Conclusions
          These results demonstrate that amiA encodes a negative regulatory protein which interacts with P2. Since amiA has homology to DNA-binding proteins, it is likely that it exerts the regulatory effect by binding to the promoter to prevent transcription.

Tags: acetamidase-expression, gene-regulation, mycobacterium-smegmatis, nih, promoter-activity
Organization: U.S. Department of Health & Human Services
Compound 525316: D-Erythro-Pentofuranose, 2-deoxy-1,3,5-tris-O-(trimethylsilyl)-

Chemical compound data from PubChem database. IUPAC Name: trimethyl-[4-trimethylsilyloxy-5-(trimethylsilyloxymethyl)oxolan-2-yl]oxysilane. Molecular Formula: C14H34O4Si3. Molecular Weight: 350.67. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2015 CMHS Uniform Reporting System (URS) Table for Massachusetts

2015 Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for Massachusetts. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant, massachusetts, mental-health-services, outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Pooling data for Number Needed to Treat: no problems for apples

Objective
          To consider the problem of the calculation of number needed to treat (NNT) derived from risk difference, odds ratio, and raw pooled events shown to give different results using data from a review of nursing interventions for smoking cessation.
        
        
          Discussion
          A review of nursing interventions for smoking cessation from the Cochrane Library provided different values for NNT depending on how NNTs were calculated. The Cochrane review was evaluated for clinical heterogeneity using L'Abbé plot and subsequent analysis by secondary and primary care settings.
          Three studies in primary care had low (4%) baseline quit rates, and nursing interventions were without effect. Seven trials in hospital settings with patients after cardiac surgery, or heart attack, or even with cancer, had high baseline quit rates (25%). Nursing intervention to stop smoking in the hospital setting was effective, with an NNT of 14 (95% confidence interval 9 to 26). The assumptions involved in using risk difference and odds ratio scales for calculating NNTs are discussed.
        
        
          Summary
          Clinical common sense and concentration on raw data helps to detect clinical heterogeneity. Once robust statistical tests have told us that an intervention works, we then need to know how well it works. The number needed to treat or harm is just one way of showing that, and when used sensibly can be a useful tool.

Tags: clinical-heterogeneity, nih, number-needed-to-treat, nursing-intervention, smoking-cessation
Organization: U.S. Department of Health & Human Services
An innovative approach to developing the reflective skills of medical students

Background
          Development of the reflective skills of medical students is an acknowledged objective of medical education.
        
        
          Description
          Description of an educational exercise which uses an email-based process for developing the reflective skills of undergraduate medical students. Student quotations illustrate learning outcomes qualitatively.
        
        
          Discussion
          The process described is immediate, direct, linked to learning objectives, enables rapid responses to be given to the students individually, and is followed by group sharing of learning. It provides a rigorous and robust feedback loop for students. It is relatively economic for teachers and incidentally benefits curriculum design and evolution. The approach supports development of a reflective approach to learning.

Tags: educational-intervention, medical-education, medical-students, nih, reflective-learning
Organization: U.S. Department of Health & Human Services
2012 NSSATS State Profiles

This is a National Survey of Substance Abuse Treatment Services (N-SSATS) annual report showing all state profiles in 2012. N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 States, the District of Columbia, and other U.S. jurisdictions.

Tags: behavioral-health-services, n-ssats, samhsa, substance-abuse-treatment, treatment-facilities
Organization: U.S. Department of Health & Human Services
2021 Uniform Reporting System (URS) Table For California

This is the 2021 Uniform Reporting System (URS) Output Tables for California. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant, california, mental-health-services, outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
New Mexico (NM)

This report presents estimates for measures of substance use and mental health based on the combined 2010 and 2011 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for New Mexico for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: mental-health, new-mexico, nsduh, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Characterization of adjacent breast tumors using oligonucleotide microarrays

Background
          Current methodology often cannot distinguish second primary breast cancers from multifocal disease, a potentially important distinction for clinical management. In the present study we evaluated the use of oligonucleotide-based microarray analysis in determining the clonality of tumors by comparing gene expression profiles.
        
        
          Method
          Total RNA was extracted from two tumors with no apparent physical connection that were located in the right breast of an 87-year-old woman diagnosed with invasive ductal carcinoma (IDC). The RNA was hybridized to the Affymetrix Human Genome U95A Gene Chip® (12,500 known human genes) and analyzed using the Gene Chip Analysis Suite® 3.3 (Affymetrix, Inc, Santa Clara, CA, USA) and JMPIN® 3.2.6 (SAS Institute, Inc, Cary, NC, USA). Gene expression profiles of tumors from five additional patients were compared in order to evaluate the heterogeneity in gene expression between tumors with similar clinical characteristics.
        
        
          Results
          The adjacent breast tumors had a pairwise correlation coefficient of 0.987, and were essentially indistinguishable by microarray analysis. Analysis of gene expression profiles from different individuals, however, generated a pairwise correlation coefficient of 0.710.
        
        
          Conclusion
          Transcriptional profiling may be a useful diagnostic tool for determining tumor clonality and heterogeneity, and may ultimately impact on therapeutic decision making.

Tags: breast-cancer, gene-expression, microarray-analysis, nih, tumor-clonality
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: New York, 2013

This is a behavioral health report for the state of New York. It uses the  National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment Services (NSSATS) to address the topics of youth substance use , youth mental health and treatment, adult mental health and treatment, substance use, substance use treatment for the years 2008 to 2012.

Tags: behavioral-health, mental-health, samhsa, substance-use, youth-mental-health
Organization: U.S. Department of Health & Human Services
Compound 525616: N,N-Dimethyl-N'-butyl-p-methoxybenzamidine

Chemical compound data from PubChem database. IUPAC Name: N'-butyl-4-methoxy-N,N-dimethylbenzenecarboximidamide. Molecular Formula: C14H22N2O. Molecular Weight: 234.34. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Child is Identified as a Special Needs Adoption: 10/1/2009 - 9/30/2010

This report provides state-specific data from fiscal year 2010 about whether an adoption through a public agency was identified as a special needs adoption.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: adoption, data, fiscal, need, policy
Organization: U.S. Department of Health & Human Services
2012 State Profile - Idaho

This is a National Survey of Substance Abuse Treatment Services (N-SSATS) annual report showing the state profile for Idaho in 2012. N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 States, the District of Columbia, and other U.S. jurisdictions.

Tags: idaho, n-ssats, samhsa, substance-abuse-treatment, treatment-facilities
Organization: U.S. Department of Health & Human Services
2014 CMHS Uniform Reporting System (URS) Table for Idaho

2014 Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for Idaho. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, idaho, mental-health-services, outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Patients Who Are Privately Insured Receive Limited Follow-up Services After Opioid-Related Hospitalizations

There has been a significant increase in hospitalizations for opioid misuse in recent years. Using 2010-2014 MarketScan commercial data, this report finds that 40 percent of patients do not receive any follow-up services within 30 days after an opioid-related hospitalization. Only 11 percent of patients received the recommended combination of both medication and a therapeutic service.

Tags: follow-up-care, marketscan-data, opioid-related-hospitalizations, private-insurance, samhsa
Organization: U.S. Department of Health & Human Services
The relationship between FV Leiden and pulmonary embolism

Pulmonary embolism (PE) is one of the leading causes of in-patient hospital deaths. As a consequence, the identification of hemostatic variables that could identify those at risk would be important in reducing mortality. It has previously been thought that deep vein thrombosis and PE are a single disease entity and would, therefore, have the same risk factors. This view is changing, however, with the realization that the prevalence of FV Leiden, a recognized genetic risk factor for deep vein thrombosis, may be a 'milder' genetic risk factor for PE. These observations suggest that PE is not only associated with a different set of risk factors, but may be reflective of a different clot structure.

Tags: factor-v-leiden, genetic-risk-factors, nih, pulmonary-embolism, venous-thromboembolism
Organization: U.S. Department of Health & Human Services
High incidence of Epstein-Barr virus, cytomegalovirus and human herpesvirus 6 infections in children with cancer

Background
          A prospective single-center study was performed to study infection with lymphotropic herpesviruses (LH) Epstein-Barr virus (EBV), cytomegalovirus (CMV) and human herpesvirus 6 (HHV-6) in children with cancer.
        
        
          Methods
          The group of 186 children was examined for the presence of LH before, during and 2 months after the end of anticancer treatment. Serology of EBV and CMV was monitored in all children, serology of HHV-6 and DNA analysis of all three LH was monitored in 70 children.
        
        
          Results
          At the time of cancer diagnosis (pre-treatment), there was no difference between cancer patients and age-matched healthy controls in overall IgG seropositivity for EBV (68.8% vs. 72.0%; p = 0.47) and CMV (37.6% vs. 41.7%; p = 0.36). During anticancer therapy, primary or reactivated EBV and CMV infection was present in 65 (34.9%) and 66 (35.4%) of 186 patients, respectively, leading to increased overall post-treatment IgG seropositivity that was significantly different from controls for EBV (86.6% vs. 72.0%; p = 0.0004) and CMV (67.7% vs. 41.7%; p < 0.0001). Overall pre-treatment IgG seropositivity for HHV-6 was significantly lower in patients than in controls (80.6% vs. 91.3%; p = 0.0231) which may be in agreement with Greaves hypothesis of protective effect of common infections in infancy to cancer development. Primary or reactivated HHV-6 infection was present in 23 (32.9%) of 70 patients during anticancer therapy leading to post-treatment IgG seropositivity that was not significantly different from controls (94.3% vs. 91.3%; p = 0.58). The LH infection occurred independently from leukodepleted blood transfusions given. Combination of serology and DNA analysis in detection of symptomatic EBV or CMV infection was superior to serology alone.
        
        
          Conclusion
          EBV, CMV and HHV-6 infections are frequently present during therapy of pediatric malignancy.

Tags: childhood-cancer, cytomegalovirus, epstein-barr-virus, human-herpesvirus-6, nih
Organization: U.S. Department of Health & Human Services