AndreaBozzo/ceres-open-data-index huggingface dataset:
One in Three Diabetic Young Adults Reports Past Month Binge Drinking (2006 to 2010 NSDUH)

This report uses 2006 to 2010 National Survey on Drug Use and Health (NSDUH) to assess past month binge alcohol use among adults aged 18 or older by whether they have diabetes. Results are shown by age group.

Tags: binge-drinking, diabetes-mellitus, nsduh-data, samhsa, young-adults
Organization: U.S. Department of Health & Human Services
Natural antisense RNA inhibits the expression of BCMA, a tumour necrosis factor receptor homologue.

Background
          BCMA (B-cell maturation) belongs to the tumour necrosis factor receptor gene family, and is specifically expressed in mature B lymphocytes. Antisense BCMA RNA is produced by transcription from the same locus and has typical mRNA features, e.g, polyadenylation, splicing, Kozak consensus sequence and an ORF (p12). To investigate the function of antisense BCMA RNA, we expressed BCMA in cell lines, in the presence of antisense p12 or a mutant lacking the initiation ATG codon (p12-ATG).
        
        
          Results
          Overexpression of both p12 and p12-ATG antisense BCMA resulted in a large decrease in the amount of BCMA protein produced, with no change in BCMA RNA levels, indicating that BCMA expression is regulated by antisense BCMA RNA at the translational level. We have also observed slight adenosine modifications, suggestive of the activity of a double-stranded RNA-specific adenosine deaminase.
        
        
          Conclusion
          These data suggest that antisense BCMA may operate under physiological conditions using similar antisense-mediated control mechanisms, to inhibit the expression of the BCMA gene.

Tags: antisense-rna, b-lymphocytes, bcma-expression, nih, translational-regulation
Organization: U.S. Department of Health & Human Services
Washington (WA)

This report presents Washington\'s estimates for 25 measures of substance use and mental health based on the combined 2009 and 2010 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for Washington for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: mental-health, nsduh-data, samhsa, substance-use, washington-state
Organization: U.S. Department of Health & Human Services
Risk and Protective Factor Tables (Standard Errors and P Values) - 3.1 to 3.25

These detailed tables present standard errors for totals and prevalence estimates of risk and protective factors regarding substance use from the 2012 National Survey on Drug Use and Health (NSDUH). The factors include perceptions of 1) risk of substance use, 2) availability of substances, 3) parental disapproval of youth substance use, 4) peer substance use. These factors include measures of delinquent behavior, religious involvement, exposure to prevention messages, and parental involvement.  Standard errors are provided by age group, gender, race/ethnicity, geographic area, and youth substance use behavior. Standard errors are provided for both 2012 and 2011.

Tags: nsduh-2012, protective-factors, samhsa, substance-use-risk, youth-substance-use
Organization: U.S. Department of Health & Human Services
Compound 527299: Propyl eicosanoate

Chemical compound data from PubChem database. IUPAC Name: propyl icosanoate. Molecular Formula: C23H46O2. Molecular Weight: 354.6. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Different effects of antisense RelA p65 and NF-κB1 p50 oligonucleotides on the nuclear factor-κB mediated expression of ICAM-1 in human coronary endothelial and smooth muscle cells

Background
          Activation of nuclear factor-κB (NF-κB) is one of the key events in early atherosclerosis and restenosis. We hypothesized that tumor necrosis factor-α (TNF-α) induced and NF-κB mediated expression of intercellular adhesion molecule-1 (ICAM-1) can be inhibited by antisense RelA p65 and NF-κB1 p50 oligonucleotides (RelA p65 and NF-κB1 p50).
        
        
          Results
          Smooth muscle cells (SMC) from human coronary plaque material (HCPSMC, plaque material of 52 patients), SMC from the human coronary media (HCMSMC), human endothelial cells (EC) from umbilical veins (HUVEC), and human coronary EC (HCAEC) were successfully isolated (HCPSMC, HUVEC), identified and cultured (HCPSMC, HCMSMC, HUVEC, HCAEC). 12 hrs prior to TNF-α stimulus (20 ng/mL, 6 hrs) RelA p65 and NF-κB1 p50 (1, 2, 4, 10, 20, and 30 μM) and controls were added for a period of 18 hrs. In HUVEC and HCAEC there was a dose dependent inhibition of ICAM-1 expression after adding of both RelA p65 and NF-κB1 p50. No inhibitory effect was seen after incubation of HCMSMC with RelA p65 and NF-κB1 p50. A moderate inhibition of ICAM-1 expression was found after simultaneous addition of RelA p65 and NF-κB1 p50 to HCPSMC, no inhibitory effect was detected after individual addition of RelA p65 and NF-κB1 p50.
        
        
          Conclusions
          The data point out that differences exist in the NF-κB mediated expression of ICAM-1 between EC and SMC. Experimental antisense strategies directed against RelA p65 and NF-κB1 p50 in early atherosclerosis and restenosis are promising in HCAEC but will be confronted with redundant pathways in HCMSMC and HCPSMC.

Tags: atherosclerosis, coronary-cells, icam-1-expression, nf-b-inhibition, nih
Organization: U.S. Department of Health & Human Services
The probability of cost-effectiveness

Background
          The study of cost-effectiveness comparisons between competing medical interventions has led to a variety of proposals for quantifying cost-effectiveness. The differences between the various approaches can be subtle, and one purpose of this article is to clarify some important distinctions.
        
        
          Discussion
          We discuss alternative measures in the framework of individual, patient-level, incremental net benefits. In particular we examine the probability of cost-effectiveness for an individual, proposed by Willan.
        
        
          Summary
          We argue that this is a useful addition to the range of cost-effectiveness measures, but will be of secondary interest to most decision makers. We also demonstrate that Willan's proposed estimate of this probability is logically flawed.

Tags: cost-effectiveness, health-economics, medical-interventions, net-benefits, nih
Organization: U.S. Department of Health & Human Services
Iowa: 2011-2012 NSDUH

This report presents Iowa\'s estimates for 25 measures of substance use and mental health based on the combined 2011 and 2012 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided by State and for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: iowa-nsduh, mental-health, samhsa, substance-use, suicidal-ideation
Organization: U.S. Department of Health & Human Services
The role of surfactant in asthma

Pulmonary surfactant is a unique mixture of lipids and surfactant-specific proteins that covers the entire alveolar surface of the lungs. Surfactant is not restricted to the alveolar compartment; it also reaches terminal conducting airways and is present in upper airway secretions. While the role of surfactant in the alveolar compartment has been intensively elucidated both in health and disease states, the possible role of surfactant in the airways requires further research. This review summarizes the current knowledge on surfactant functions regarding the airway compartment and highlights the impact of various surfactant components on allergic inflammation in asthma.

Tags: airway-allergy, asthma, asthma-inflammation, nih, pulmonary-surfactant
Organization: U.S. Department of Health & Human Services
2010 CMHS Uniform Reporting System (URS) Output Tables for Kansas

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2010. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, national-outcome-measures, samhsa, substance-abuse
Organization: U.S. Department of Health & Human Services
2011 CMHS Uniform Reporting System (URS) Output Tables for North Carolina

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2011. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, evidence-based-practices, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
2019 Uniform Reporting System (URS) Table for New Hampshire

These are the 2019 Uniform Reporting System (URS) Output Tables for New Hampshire. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: mental-health-services, national-outcome-measures, samhsa, substance-abuse-treatment, urs-data
Organization: U.S. Department of Health & Human Services
Compound 525465: 2-(Tert-butylsulfanyl)ethane-1-thiol

Chemical compound data from PubChem database. IUPAC Name: 2-tert-butylsulfanylethanethiol. Molecular Formula: C6H14S2. Molecular Weight: 150.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2012 State Profile - Virginia

This is a National Survey of Substance Abuse Treatment Services (N-SSATS) annual report showing the state profile for Virginia in 2012. N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 States, the District of Columbia, and other U.S. jurisdictions.

Tags: behavioral-health-services, n-ssats, samhsa, substance-abuse-treatment, virginia
Organization: U.S. Department of Health & Human Services
States’ Consultation and Collaboration with Tribes and Reported Compliance with the Indian Child Welfare Act: Information from States’ and Tribes’ 2015–2019 Child and Family Services Plans

This report from the Children’s Bureau summarizes information related to state implementation of the Indian Child Welfare Act (ICWA), and consultation and collaboration with tribes. The report also includes information reported in a sample of tribes’ CFSPs pertaining to ways in which states consulted and collaborated with tribes.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: child, compliance, policy, reporting, scope
Organization: U.S. Department of Health & Human Services
2010 State Profile — Hawaii

This state profile includes data from facilities in Hawaii that reported to N-SSATS for the survey reference date March 31, 2010. Data were collected on the location, characteristics, services offered, and number of clients in treatment at alcohol and drug abuse treatment facilities (both public and private) in Hawaii. In Hawaii, 119 substance abuse treatment facilities were included in the 2010 N-SSATS, reporting that there were 4,200 clients in substance abuse treatment on March 31, 2010. The survey response rate in Hawaii was 96.8%.

Tags: alcohol-drug-abuse, hawaii, n-ssats, samhsa, substance-abuse-treatment
Organization: U.S. Department of Health & Human Services
Compound 525488: 3-(Methylsulfanyl)propane-1-thiol

Chemical compound data from PubChem database. IUPAC Name: 3-methylsulfanylpropane-1-thiol. Molecular Formula: C4H10S2. Molecular Weight: 122.3. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Behavioral Health Barometer: HHS Region IX, 2014

This is a behavioral health report for HHS Region IX of the United States and utilizes data from the National Survey on Drug Use and Health (NSDUH) and the National Survey of Substance Abuse Treatment (N-SSATS), collected annually. The topics addressed in the reports include youth substance use, adult mental health and treatment, and substance use treatment.

Tags: behavioral-health, hhs-region-ix, mental-health, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
The stressed synovium

This review focuses on the mechanisms of stress response in the synovial tissue of rheumatoid arthritis. The major stress factors, such as heat stress, shear stress, proinflammatory cytokines and oxidative stress, are discussed and reviewed, focusing on their potential to induce a stress response in the synovial tissue. Several pathways of stress signalling molecules are found to be activated in the synovial membrane of rheumatoid arthritis; of these the most important examples are heat shock proteins, mitogen-activated protein kinases, stress-activated protein kinases and molecules involved in the oxidative stress pathways. The expression of these pathways in vitro and in vivo as well as the consequences of stress signalling in the rheumatoid synovium are discussed. Stress signalling is part of a cellular response to potentially harmful stimuli and thus is essentially involved in the process of synovitis. Stress signalling pathways are therefore new and promising targets of future anti-rheumatic therapies.

Tags: inflammation, nih, rheumatoid-arthritis, stress-response, synovial-tissue
Organization: U.S. Department of Health & Human Services
Table 9. 2011-2012 NSDUH Alcohol Use in the Past Month, by Age Group and State

Table 9. Alcohol Use in the Past Month, by Age Group and State: Percentages, Annual Averages Based on 2011 and 2012 NSDUHs. Results are provided by State and for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: alcohol-use, samhsa, state-level-data, substance-abuse, youth-alcohol
Organization: U.S. Department of Health & Human Services
2020 Uniform Reporting System (URS) Table For Wyoming

This is the 2020 Uniform Reporting System (URS) Output Tables for Wyoming. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: behavioral-health, mental-health-services, national-outcome-measures, samhsa, wyoming
Organization: U.S. Department of Health & Human Services
Children with SHCN: Data Brief 1

This data brief examines outcomes of children according to their special health care needs (SHCN) status, specifically their age at entry, gender, race and ethnicity, adoption history, placement setting, case plan goal, discharge reasons, and time to exit.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: adoption, data, need, policy, reporting
Organization: U.S. Department of Health & Human Services
A basis for a visual language for describing, archiving and analyzing functional models of complex biological systems

Background:
          We propose that a computerized, internet-based graphical description language for systems biology will be essential for describing, archiving and analyzing complex problems of biological function in health and disease.
        
        
          Results:
          We outline here a conceptual basis for designing such a language and describe BioD, a prototype language that we have used to explore the utility and feasibility of this approach to functional biology. Using example models, we demonstrate that a rather limited lexicon of icons and arrows suffices to describe complex cell-biological systems as discrete models that can be posted and linked on the internet.
        
        
          Conclusions:
          Given available computer and internet technology, BioD may be implemented as an extensible, multidisciplinary language that can be used to archive functional systems knowledge and be extended to support both qualitative and quantitative functional analysis.

Tags: biological-networks, computational-biology, functional-modeling, nih, systems-biology
Organization: U.S. Department of Health & Human Services
Helicobacter pylori (H pylori) infection in Greece: the changing prevalence during a ten-year period and its antigenic profile

Background
          To evaluate changes in H pylori infection prevalence in Greece during a ten-year period, and to examine its antigenic profile.
        
        
          Methods
          Three groups of patients were studied. Group O-87: Banked serum samples of 200 consecutive adult outpatients, from the Hepato-Gastroenterology clinic of a teaching hospital at Athens, collected in 1987. Group O-97: Serum samples of 201 similarly selected outpatients from the same Unit, collected in 1997. Group BD-97: Serum samples of 120 consecutive blood donors from the same hospital, collected in 1997. H pylori IgG antibody seroprevalence was studied by a quantitative ELISA. Antigenic profile was studied by western-blot IgG assay, in 62 IgG positive patients of O-97 and BD-97. Results were analyzed by conventional statistics and multivariate regression analysis.
        
        
          Results
          The H pylori seroprevalence increased with age in the three tested groups. In O-97, seroprevalence did not differ from that, in BD-97. On the contrary, there was a significant decrease in seropositivity between O-87 and O-97 (59.5% vs 49.2%, p = 0.039). Multiple regression analysis showed that age over 35 years (OR:3.45, 95% CI:1.59–7.49, p = 0.002) and year of patients' selection – that is 1987 or 1997 – (OR:1.73, 95% CI:1.14–2.65 for 1987, p = 0.010), were independent risk factors of H pylori infection. The seroprevalence of CagA+ and VacA+ strains was 77.4% and 58.5%, respectively, and type I(CagA+/VacA+) strains were significantly more common than type II(CagA-/VacA-) strains (59.7% vs 22.6%, p < 0.001).
        
        
          Conclusions
          During a ten-year period, we found a significant decrease of H pylori infection in Greece and our data support the birth cohort phenomenon as an explanation for the age-dependent increase of H pylori infection. The prevalence of CagA and/or VacA positive strains is relatively high, in a country with low incidence of gastric cancer.

Tags: greece, h-pylori-prevalence, helicobacter-pylori, nih, seroprevalence-study
Organization: U.S. Department of Health & Human Services
Molecular profile of synovial fibroblasts in rheumatoid arthritis depends on the stage of proliferation

The aim of this study was to explore the molecular profile of proliferating rheumatoid arthritis synovial fibroblasts (RA-SF). Total RNA was extracted from two cultures of RA-SF (low-density [LD] proliferating cells and high-density [HD] nonproliferating cells) and suppression subtractive hybridization was performed to compare differential gene expression of these two cultures. Subtracted cDNA was subcloned, and nucleotide sequences were analyzed to identify each clone. Differential expression of distinct clones was confirmed by semiquantitative RT-PCR. The expression of certain genes in synovial tissues was examined by in situ hybridization. In both LD and HD cells, 44 clones were upregulated. Of the 88 total clones, 46 were identical to sequences that have previously been characterized. Twenty-nine clones were identical to cDNAs that have been identified, but with unknown functions so far, and 13 clones did not show any significant homology to sequences in GenBank (NCBI). Differential expression of distinct clones was confirmed by RT-PCR. In situ hybridization showed that certain genes, such as S100A4, NFAT5, unr and Fbx3, were also expressed predominantly in synovial tissues from patients with RA but not from normal individuals. The expression of distinct genes in proliferating RA-SF could also be found in RA synovium, suggesting that these molecules are involved in synovial activation in RA. Most importantly, the data indicate that the expression of certain genes in RA-SF depends on the stage of proliferation; therefore, the stage needs to be considered in any analysis of differential gene expression in SF.

Tags: gene-expression, molecular-profiling, nih, rheumatoid-arthritis, synovial-fibroblasts
Organization: U.S. Department of Health & Human Services
The BHSIS Report: Multi-year Analyses of TEDS and N-SSATS

This is a Treatment Episode Data Set (TEDS) and National Survey of Substance Abuse Treatment Services (N-SSATS) short report about the online analytic tools users can access to explore data on US substance abuse admissions and facilities. This spotlight is a multi-year analysis that covers 1992-2010 TEDS and 1997-2010 N-SSATS.

Tags: facility-survey, n-ssats, samhsa, substance-abuse-treatment, treatment-episode-data
Organization: U.S. Department of Health & Human Services