AndreaBozzo/ceres-open-data-index huggingface dataset:
PKQuest: volatile solutes – application to enflurane, nitrous oxide, halothane, methoxyflurane and toluene pharmacokinetics

Background
          The application of physiologically based pharmacokinetic models (PBPK) to human studies has been limited by the lack of the detailed organ information that is required for this analysis. PKQuest is a new generic PBPK that is designed to avoid this problem by using a set of "standard human" default parameters that are applicable to most solutes.
        
        
          Results
          PKQuest is used to model the human pharmacokinetics of the volatile solutes. A "standard human" value for the lipid content of the blood and each organ (klip) was chosen. This set of klip and the oil/water partition coefficient then specifies the organ/blood partition for each organ. Using this approach, the pharmacokinetics of inert volatile solute is completely specified by just 2 parameters: the water/air and oil/water partition coefficients. The model predictions of PKQuest were in good agreement with the experimental data for the inert solutes enflurane and nitrous oxide and the metabolized solutes halothane and toluene.
        
        
          Methods
          The experimental data that was modeled was taken from previous publications.
        
        
          Conclusions
          This approach greatly increases the predictive power of the PBPK. For inert volatile solutes the pharmacokinetics are determined just from the water/air and oil/water partition coefficient. Methoxyflurane cannot be modeled by this PBPK because the arterial and end tidal partial pressures are not equal (as assumed in the PBPK). This inequality results from the "washin-washout" artifact in the large airways that is established for solutes with large water/air partition coefficients.
          PKQuest and the worked examples are available on the web .

Tags: anesthetics, nih, pbpk-modeling, pharmacokinetics, volatile-solutes
Organization: U.S. Department of Health & Human Services
AFCARS Report #20

This report provides preliminary estimates of AFCARS data for FY 2012. Preliminary reports of AFCARS data include data received by September 30 for the report period ending March 31 and by March 31 for the report period ending September 30. This generally encompasses the required data submissions and submission of corrected data by States to avoid possible financial penalties.

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: assessment, child, data, policy, reporting
Organization: U.S. Department of Health & Human Services
Services Offered by Outpatient-Only Opioid Treatment Programs: 2012

This is an National Survey of Substance Abuse Treatment Services (NSSATS) short report. It is about what services are offered by opiod treatment programs in 2012.

Tags: nssats, opioid-treatment, outpatient-treatment, samhsa, substance-abuse-services
Organization: U.S. Department of Health & Human Services
2021 Uniform Reporting System (URS) Table For Hawaii

This is the 2021 Uniform Reporting System (URS) Output Tables for Hawaii. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant, hawaii, mental-health-services, noms, samhsa
Organization: U.S. Department of Health & Human Services
Evaluation of thresholds for the detection of binding sites for regulatory proteins in

Background
          Sites in DNA that bind regulatory proteins can be detected computationally in various ways. Pattern discovery methods analyze collections of genes suspected to be co-regulated on the evidence, for example, of clustering of transcriptome data. Pattern searching methods use sequences with known binding sites to find other genes regulated by a given protein. Such computational methods are important strategies in the discovery and elaboration of regulatory networks and can provide the experimental biologist with a precise prediction of a binding site or identify a gene as a member of a set of co-regulated genes (a regulon). As more variations on such methods are published, however, thorough evaluation is necessary, as performance may differ depending on the conditions of use. Detailed evaluation also helps to improve and understand the behavior of the different methods and computational strategies.
        
        
          Results
          We used a collection of 86 regulons from Escherichia coli as datasets to evaluate two methods for pattern discovery and pattern searching: dyad analysis/dyad sweeping using the program Dyad-analysis, and multiple alignment using the programs Consensus/Patser. Clearly defined statistical parameters are used to evaluate the two methods in different situations. We placed particular emphasis on minimizing the rate of false positives.
        
        
          Conclusions
          As a general rule, sensors obtained from experimentally reported binding sites in DNA frequently locate true sites as the highest-scoring sequences within a given upstream region, especially using Consensus/Patser. Pattern discovery is still an unsolved problem, although in the cases where Dyad-analysis finds significant dyads (around 50%), these frequently correspond to true binding sites. With more robust methods, regulatory predictions could help identify the function of unknown genes.

Tags: binding-sites, dna-analysis, gene-regulation, nih, regulatory-proteins
Organization: U.S. Department of Health & Human Services
2013 CMHS Uniform Reporting System (URS) Tables for Indiana

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Tables for Indiana for 2013. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program.  State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant-program, community-mental-health, mental-health-services, outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Compound 525422: 2-Methyl-5-thianonane

Chemical compound data from PubChem database. IUPAC Name: 1-butylsulfanyl-3-methylbutane. Molecular Formula: C9H20S. Molecular Weight: 160.32. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Archive for State AFCARS Report

The AFCARS Report (TAR) presents a national summary of foster care and adoption counts/data during a given fiscal year.

Alabama

Alaska

Arizona

Arkansas

California

Colorado

Connecticut

Delaware

District of Columbia

Florida

Georgia

Hawaii

Idaho

Illinois

Indiana

Iowa

Kansas

Kentucky

Louisiana

Maine

Maryland

Massachusetts

Michigan

Minnesota

Mississippi

Missouri

Montana

Nebraska

New Hampshire

New Jersey

New Mexico

New York

Nevada

North Carolina

North Dakota

Ohio

Oklahoma

Oregon

Pennsylvania

Puerto Rico

Rhode Island

South Carolina

South Dakota

Tennessee

Texas

Utah

Vermont

Virginia

Washington

West Virginia

Wisconsin

Wyoming

Metadata-only record linking to the original dataset. Open original dataset below.

Tags: adoption, assessment, fiscal, foster, policy
Organization: U.S. Department of Health & Human Services
NSDUH 2022 Pair Level Sampling Weight Report

Learn about the techniques used to create weights for the 2022 National Survey on Drug Use and Health (NSDUH) at the pair and questionnaire dwelling unit (QDU) levels. NSDUH is designed so that some of the sampled households have both an adult and a youth respondent who are paired. Because of this, NSDUH allows for estimating characteristics at the person level, pair level, or QDU level. This report describes pair selection probabilities, the generalized exponential model (including predictor variables used), and the multiple weight components that are used for pair or QDU levels of analysis. An evaluation of the calibration weights is also included.Chapters:Introduces the report.Discusses the probability of selection for pairs and QDUs.Briefly describes of the generalized exponential model.Describes the predictor variables for the model calibration.Defines extreme weights.Discusses weight calibrations.Evaluates the calibration weights.Appendices include technical details about the model and the evaluations that were performed.

Tags: nsduh-sampling-weights, pair-level-analysis, qdu-level-analysis, samhsa, substance-use-survey
Organization: U.S. Department of Health & Human Services
2010 CMHS Uniform Reporting System (URS) Output Tables for Massachusetts

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2010. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: block-grant, community-mental-health, mental-health-services, outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
PKA, PKC, and AKAP localization in and around the neuromuscular junction

Background
          One mechanism that directs the action of the second messengers, cAMP and diacylglycerol, is the compartmentalization of protein kinase A (PKA) and protein kinase C (PKC). A-kinase anchoring proteins (AKAPs) can recruit both enzymes to specific subcellular locations via interactions with the various isoforms of each family of kinases. We found previously that a new class of AKAPs, dual-specific AKAPs, denoted D-AKAP1 and D-AKAP2, bind to RIα in addition to the RII subunits.
        
        
          Results
          Immunohistochemistry and confocal microscopy were used here to determine that D-AKAP1 colocalizes with RIα at the postsynaptic membrane of the vertebrate neuromuscular junction (NMJ) and the adjacent muscle, but not in the presynaptic region. The labeling pattern for RIα and D-AKAP1 overlapped with mitochondrial staining in the muscle fibers, consistent with our previous work showing D-AKAP1 association with mitochondria in cultured cells. The immunoreactivity of D-AKAP2 was distinct from that of D-AKAP1. We also report here that even though the PKA type II subunits (RIIα and RIIβ) are localized at the NMJ, their patterns are distinctive and differ from the other R and D-AKAP patterns examined. PKCβ appeared to colocalize with the AKAP, gravin, at the postsynaptic membrane.
        
        
          Conclusions
          The kinases and AKAPs investigated have distinct patterns of colocalization, which suggest a complex arrangement of signaling micro-environments. Because the labeling patterns for RIα and D-AKAP 1 are similar in the muscle fibers and at the postsynaptic membrane, it may be that this AKAP anchors RIα in these regions. Likewise, gravin may be an anchor of PKCβ at the NMJ.

Tags: a-kinase-anchoring-proteins, neuromuscular-junction, nih, protein-kinase-a, protein-kinase-c
Organization: U.S. Department of Health & Human Services
Little qualitative RNA misexpression in sterile male F

Background
          Although the genetics of hybrid sterility has been the subject of evolutionary studies for over sixty years, no one has shown the reason(s) why alleles that operate normally within species fail to function in another genetic background. Several lines of evidence suggest that failures in normal gene transcription contribute to hybrid dysfunctions, but genome-wide studies of gene expression in pure-species and hybrids have not been undertaken. Here, we study genome-wide patterns of expression in Drosophila pseudoobscura, D. persimilis, and their sterile F1 hybrid males using differential display.
        
        
          Results
          Over five thousand amplifications were analyzed, and 3312 were present in amplifications from both of the pure species. Of these, 28 (0.5%) were not present in amplifications from adult F1 hybrid males. Using product-specific primers, we were able to confirm one of nine of the transcripts putatively misexpressed in hybrids. This transcript was shown to be male-specific, but without detectable homology to D. melanogaster sequence.
        
        
          Conclusion
          We tentatively conclude that hybrid sterility can evolve without widespread, qualitative misexpression of transcripts in species hybrids. We suggest that, if more misexpression exists in sterile hybrids, it is likely to be quantitative, tissue-specific, and/ or limited to earlier developmental stages. Although several caveats apply, this study was a first attempt to determine the mechanistic basis of hybrid sterility, and one potential candidate gene has been identified for further study.

Tags: drosophila, gene-expression, hybrid-sterility, nih, rna-misexpression
Organization: U.S. Department of Health & Human Services
Compound 527338: 2-(3,5-Dimethylphenyl)adamantane

Chemical compound data from PubChem database. IUPAC Name: 2-(3,5-dimethylphenyl)adamantane. Molecular Formula: C18H24. Molecular Weight: 240.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
National Survey of Substance Abuse Treatment Services: State Profiles 2015

The 2014 National Survey of Substance Abuse Treatment Services (N-SSATS) is an annual survey of facilities providing substance abuse treatment. The N-SSATS, conducted by the Substance Abuse and Mental Health Services Administration (SAMHSA), is designed to collect data on the location, characteristics, services offered, and number of clients in treatment at alcohol and drug abuse facilities (both public and private) throughout the 50 states, the District of Columbia, and other U.S. jurisdictions.

Tags: mental-health-services, n-ssats, samhsa, substance-abuse-treatment, treatment-facilities
Organization: U.S. Department of Health & Human Services
Mississippi (MS)

This report presents estimates for measures of substance use and mental health based on the combined 2010 and 2011 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for Mississippi for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: mental-health, mississippi, nsduh, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Table 11. Perceptions of Great Risk from Having Five or More Drinks of an Alcoholic Beverage Once or Twice a Week, by Age Group and State: Percentages, Annual Averages Based on 2013 and 2014 NSDUHs

Table 11. Perceptions of Great Risk from Having Five or More Drinks of an Alcoholic Beverage Once or Twice a Week, by Age Group and State: Percentages, Annual Averages Based on 2013 and 2014 NSDUHs

Tags: alcohol-consumption, alcohol-risk-perception, heavy-drinking, nsduh-data, samhsa
Organization: U.S. Department of Health & Human Services
4.15a Facility licensing, certification, or accreditation, by facility operation and primary focus of facility: 2010. Number

This is a National Survey of Substance Abuse Treatment Services (N-SSATS) data table showing facility licensing, certification, or accreditation, by facility operation and primary focus of facility in 2010. N-SSATS is designed to collect data on the location, characteristics, and use of alcohol and drug abuse treatment facilities and services throughout the 50 States, the District of Columbia, and other U.S. jurisdictions.

Tags: accreditation-status, facility-licensing, n-ssats, samhsa, substance-abuse-treatment
Organization: U.S. Department of Health & Human Services
To keep the catch – that is the question: a personal account of the 3rd Annual EULAR Congress, Stockholm

The 3rd Annual EULAR Congress, held in Stockholm on 12–15 June 2002, had a turnout of 8300 delegates, almost identical to last year's record attendance level in Prague. The venue was close to ideal, allowing ample space for poster sessions in the exhibition hall. The manned poster sessions were well attended, even on the last day of the Congress. The numerous invited speakers represented the world's elite, allowing the staging of excellent state-of-the-art podium sessions. The aim of attracting the young scientific community was partly achieved, but individual delegates' dependence on industry sponsorship poses potential problems. The organization was a big improvement compared to that of the two previous congresses. Approximately 1800 abstracts were submitted, an increase of 50%, resulting in a higher quality of accepted abstracts. The satellite symposia held every morning and late afternoon were well attended; thus, industry exposure of new products, both in podium sessions and at the exhibitions, was well accommodated. The Annual EULAR Congress consolidates its position as one of the two most important annual congresses of rheumatology, but EULAR economy and commercial aspects are still too dominant in relation to science.

Tags: congress-report, eular-congress, nih, rheumatology
Organization: U.S. Department of Health & Human Services
Road trips and resources: there is a better way

Background:
          Transport of critically ill patients for diagnostic and/or therapeutic management involves significant consumption of resources. In an effort to improve the delivery of care to these patients and decrease resource utilization, Hill-Rom (Batesville, IN, USA) have developed a self-contained device (CarePorterTM) designed to provide both intensive care unit (ICU) support and transport capability. We hypothesized that the use of the CarePorter when compared with a standard or specialty bed (with transfer to a stretcher) would decrease the number of personnel and time required for transport without altering the current ICU standards of care.
        
        
          Results:
          Over a 3 month period, 35 ventilated patient transports were divided into the following groups: specialty bed to stretcher (n = 13), standard bed (n = 9) and CarePorter (n = 13). The APACHE II score at the time of transport was not different between the groups, nor was the ongoing care being delivered. The CarePorter group had a statistically greater fractional inspiration of oxygen and positive end expiratory pressure, when compared with the other two groups (P < 0.05). The use of the CarePorter device decreased the number of personnel required to transport a patient (2.1 ± 0.3 vs 3.6 ± 0.5 for the standard bed and and 3.2 ± 0.7 for the specialty bed; P = 0.0001). The CarePorter also decreased the number of resources utilized for the preparation of a patient for transport (P = 0.001) when compared to the other groups. This was primarily due to the transfer of patients from specialty beds to a stretcher. Overall respiratory therapy time was also much less with the CarePorter (5.9 ± 5.7 min), when compared with the standard (26 ± 10 min) or specialty bed (22 ± 11 min) (P = 0.0008). In addition, the CarePorter group also had a higher nursing satisfaction score with the overall transport (P = 0.008).
        
        
          Conclusions:
          Use of the CarePorter device resulted in maximization of the delivery of patient care, time savings, significantly improved utilization of escort personnel

Tags: critical-care-transport, intrahospital-transport, nih, resource-utilization, ventilated-patients
Organization: U.S. Department of Health & Human Services
2014 CMHS Uniform Reporting System (URS) Table for Texas

2014 Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for Texas. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: mental-health-services, outcome-measures, samhsa, texas, urs-data
Organization: U.S. Department of Health & Human Services
Genetic determinants of mammographic density

Background
          Changes in breast density are highly correlated with steroid hormone exposure.
        
        
          Materials and methods
          In a cross-sectional study of 396 Caucasian and African-American women, we evaluated whether polymorphisms in genes involved in steroid hormone biosynthesis and metabolism, CYP17 (T27C), COMT (Val158Met), 17HSDB1 (Ser312Gly) and 3HSDB1 (Asn367Thr), predict mammographic density. We also evaluated whether associations vary by menopausal and hormone replacement therapy status.
        
        
          Results
          We found no strong consistent relationships between polymorphisms in these genes and breast density. African-American women homozygous for the Thr allele of 3HSDB1 had increased density (the absolute difference versus the Asn/Asn genotype was +19.7%; P trend = 0.02), while Caucasian homozygous women had decreased density (-5.1%; P trend = 0.04). Among premenopausal women, carriers of the Ser allele had (not significantly) greater density (versus Gly/Gly genotype: +7.1%; P trend = 0.07). In addition, among current users of hormone replacement therapy, we observed that women with the low-activity Met/Met genotype of COMT had greater breast density (versus the Val/Val genotype: +11.7%; P trend = 0.01).
        
        
          Conclusion
          Additional large studies evaluating these and other candidate breast cancer genes will be required to determine what proportion, if any, of the interindividual differences in breast density are due to underlying genetic variation in genes involved in steroid hormone biosynthesis or metabolism.

Tags: breast-density, genetic-polymorphism, mammographic-density, nih, steroid-hormones
Organization: U.S. Department of Health & Human Services
2012 Uniform Reporting System (URS) Table for Maine

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2012. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, maine, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services