AndreaBozzo/ceres-open-data-index huggingface dataset:
Rodent Research-1 (RR1) NASA Validation Flight: Mouse soleus muscle transcriptomic and epigenomic data

NASA's Rodent Research (RR) project is playing a critical role in advancing biomedical research on the physiological effects of space environments. Due to the limited resources for conducting biological experiments aboard the International Space Station (ISS), it is imperative to use crew time efficiently while maximizing high-quality science return. NASA's GeneLab project has as its primary objectives to 1) further increase the value of these experiments using a multi-omics, systems biology-based approach, and 2) disseminate these data without restrictions to the scientific community. The current investigation assessed viability of RNA, DNA, and protein extracted from archived RR-1 tissue samples for epigenomic, transcriptomic, and proteomic assays. During the first RR spaceflight experiment, a variety of tissue types were harvested from subjects, snap-frozen or RNAlater-preserved, and then stored at least a year at -80C after return to Earth. They were then prioritized for this investigation based on likelihood of significant scientific value for spaceflight research. All tissues were made available to GeneLab through the bio-specimen sharing program managed by the Ames Life Science Data Archive and included mouse adrenal glands, quadriceps, gastrocnemius, tibialis anterior, extensor digitorum longus, soleus, eye, and kidney. We report here protocols for and results of these tissue extractions, and thus, the feasibility and value of these kinds of omics analyses. In addition to providing additional opportunities for investigation of spaceflight effects on the mouse transcriptome and proteome in new kinds of tissues, our results may also be of value to program managers for the prioritization of ISS crew time for rodent research activities.

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Organization: National Aeronautics and Space Administration
Microbial Observatory (ISS-MO): Draft Genome Sequence of two Aspergillus fumigatus Strains Isolated from the International Space Station

Aspergillus fumigatus is a saprophytic, filamentous fungus that is ubiquitous outdoors (soil, decaying vegetation) and indoors (hospitals, simulated closed habitats, etc.). A. fumigatus can adapt to various environmental conditions and form airborne conidia that are the inoculum for a variety of diseases (e.g. non- and invasive pulmonary infections, allergic bronchopulmonary aspergillosis, etc.) in immunocompromised hosts. In an on-going Microbial Observatory Experiments on the International Space Station (ISS) molecular phylogeny of several fungal isolates were characterized. Two strains, ISSF 21 and IF1SW-F4, were isolated from the HEPA filter and the surface of the Cupola of the ISS, respectively. Using primers targeting the internal transcribed spacers ITS1 and 2, both isolates were identified as A. fumigatus. The whole genome sequence analysis of ISSF 21 revealed increased number of single nucleotide polymorphisms (SNPs) when compared to the reference A. fumigatus 293. Knowing that A. fumigatus is an opportunistic pathogen and microgravity highly influences the antibiotic susceptibility and pathogenicity of microorganisms, we examined pathogenicity of both ISS isolates using the zebrafish larval model. The space station isolates (ISSF-021 and IF1SW-F4) were more virulent than two clinical strains (Af293 and CEA10) whose pathogenicity was highly characterized. Here the whole genome sequences of ISSF-021 strain are being deposited.

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Organization: National Aeronautics and Space Administration
Rodent Research-1 (RR1) NASA Validation Flight: Mouse extensor digitorum longus muscle transcriptomic and epigenomic data

NASA's Rodent Research (RR) project is playing a critical role in advancing biomedical research on the physiological effects of space environments. Due to the limited resources for conducting biological experiments aboard the International Space Station (ISS), it is imperative to use crew time efficiently while maximizing high-quality science return. NASA's GeneLab project has as its primary objectives to 1) further increase the value of these experiments using a multi-omics, systems biology-based approach, and 2) disseminate these data without restrictions to the scientific community. The current investigation assessed viability of RNA, DNA, and protein extracted from archived RR-1 tissue samples for epigenomic, transcriptomic, and proteomic assays. During the first RR spaceflight experiment, a variety of tissue types were harvested from subjects, snap-frozen or RNAlater-preserved, and then stored at least a year at -80C after return to Earth. They were then prioritized for this investigation based on likelihood of significant scientific value for spaceflight research. All tissues were made available to GeneLab through the bio-specimen sharing program managed by the Ames Life Science Data Archive and included mouse adrenal glands, quadriceps, gastrocnemius, tibialis anterior, extensor digitorum longus, soleus, eye, and kidney. We report here protocols for and results of these tissue extractions, and thus, the feasibility and value of these kinds of omics analyses. In addition to providing additional opportunities for investigation of spaceflight effects on the mouse transcriptome and proteome in new kinds of tissues, our results may also be of value to program managers for the prioritization of ISS crew time for rodent research activities.

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Organization: National Aeronautics and Space Administration
MER 2 MARS NAVCAM 3 RADIOMETRIC RDR SCI V1.0

This data set contains radiometrically calibrated MER-2 Navcam data. The calibration has removed bias, dark current, and flatfield effects from the raw Navcam data, resulting in estimated radiance-on-sensor data in units of W/m^2/nm/sr. No geometric or camera-model calibrations or transformations have been applied.

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Organization: National Aeronautics and Space Administration
GALILEO ORBITER ASTEROID AND EARTH 2 SOLID STATE IMAGING 2 R

This data set has been generated by NASA's Galileo Project in order to distribute the images acquired by the Solid State Imaging (SSI) camera to the scientists and later to the Planetary Data System (PDS). The collection resides on volumes GO_0007 thru GO_0015 and consists of all images acquired by the Galileo spacecraft during the Gaspra and the second encounter with the Earth (Earth2). Included are images of Gaspra, the Earth's Moon and the Earth taken during the 1991 and 1992 encounters (SCLK 99757945 through 166324700), as well as additional star and calibration data.

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Organization: National Aeronautics and Space Administration
NuSTAR COSMOS Field X-Ray Source Catalog

To provide the census of the sources contributing to the X-ray background peak above 10 keV, the Nuclear Spectroscopic Telescope Array (NuSTAR) is performing extragalactic surveys using a three-tier &quot;wedding cake&quot; approach. In their paper, the authors present the NuSTAR survey of the COSMOS field, the medium sensitivity, and medium area &quot;tier&quot;,covering 1.7 deg&lt;sup&gt;2&lt;/sup&gt; and overlapping with both Chandra and XMM-Newton data. This survey consists of 121 NuSTAR observations for a total exposure of ~3 Ms. To fully exploit these data, the authors developed a new detection strategy, carefully tested through extensive simulations. The survey sensitivity at 20% completeness is 5.9, 2.9, and 6.4 x 10&lt;sup&gt;-14&lt;/sup&gt; erg cm&lt;sup&gt;-2&lt;/sup&gt; s&lt;sup&gt;-1&lt;/sup&gt; in the 3-24, 3-8 and 8-24 keV bands, respectively. By combining detections in 3 bands, the survey consists of a sample of 91 NuSTAR sources with luminosities ~ 10&lt;sup&gt;42&lt;/sup&gt; - 10&lt;sup&gt;45.5&lt;/sup&gt; erg s&lt;sup&gt;-1&lt;/sup&gt;and redshifts z ~ 0.04-2.5. Thirty-two sources are detected in the 8-24 keV band with fluxes ~100 times fainter than sources detected by Swift-BAT. Of the 91 detections, all but 4 are associated with a Chandra and/or XMM-Newton point-like counterpart. One source is associated with an extended lower energy X-ray source. The authors present the X-ray (hardness ratio and luminosity)and optical-to-X-ray properties. The observed fraction of candidate Compton-thick active galactic nuclei measured from the hardness ratio is between 13% - 20%. In their paper, the authors discuss the spectral properties of the source named NuSTAR J100259+0220.5 (source number 330) at a redshift z = 0.044, which has the highest hardness ratio in the entire sample. The measured column density exceeds 10&lt;sup&gt;24&lt;/sup&gt; cm&lt;sup&gt;-2&lt;/sup&gt;, implying the source is Compton-thick. This source was not previously recognized as such without the data at energies &gt;10 keV. This table was created by the HEASARC in August 2015 based on the the machine-readable versions of Table 5 (the COSMOS Field NuSTAR source catalog) that was obtained from the ApJ web site. This is a service provided by NASA HEASARC .

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Organization: National Aeronautics and Space Administration
ROSAT Hard-Spectrum X-Ray Source Catalog

This table contains a catalog of 147 serendipitous X-ray sources selected to have hard spectra (spectral indices Alpha &lt; 0.5) from a survey of 188 ROSAT fields. Such sources must be the dominant contributors to the X-ray background at faint fluxes. The authors have used Monte Carlo simulations to verify that their technique is very efficient at selecting hard sources: the survey has &gt;= 10 times as much effective area for hard sources as it has for soft sources above a 0.5 - 2 keV flux level of 10&lt;sup&gt;-14&lt;/sup&gt; erg cm&lt;sup&gt;-2&lt;/sup&gt; s&lt;sup&gt;-1&lt;/sup&gt;. The distribution of best-fitting spectral slopes of the hard sources suggests that a typical ROSAT hard source in this survey has a spectral slope Alpha ~ 0. The hard sources have a steep number-flux relation (dN/dS ~ _S&lt;sup&gt;-Gamma&lt;/sup&gt;, with a best-fitting value of Gamma = 2.72 +/- 0.12), and make up about 15% of all 0.5 - 2 keV sources with S &gt; 10&lt;sup&gt;-14&lt;/sup&gt; erg cm&lt;sup&gt;-2&lt;/sup&gt; s&lt;sup&gt;-1&lt;/sup&gt;. If their N(S) continues to fainter fluxes, the hard sources will comprise ~ 40% of sources with 5 x 10&lt;sup&gt;-15&lt;/sup&gt; &lt; S &lt; 10&lt;sup&gt;-14&lt;/sup&gt; erg cm&lt;sup&gt;-2&lt;/sup&gt; s&lt;sup&gt;-1&lt;/sup&gt;. The population of hard sources can therefore account for the harder average spectra of ROSAT sources with S &lt; 10&lt;sup&gt;-14&lt;/sup&gt;erg cm&lt;sup&gt;-2&lt;/sup&gt; s&lt;sup&gt;-1&lt;/sup&gt;. They probably make a strong contribution to the X-ray background at faint fluxes and could be the solution to the X-ray background spectral paradox. This table was created by the HEASARC in March 2012 based on &lt;a href="https://cdsarc.cds.unistra.fr/ftp/cats/J/MNRAS/318/1073"&gt;CDS Catalog J/MNRAS/318/1073&lt;/a&gt; file table2.dat, the ROSAT hard X-ray source catalog. This is a service provided by NASA HEASARC .

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Organization: National Aeronautics and Space Administration
Microbial Observatory (ISS-MO): Molecular characterization of Bacillus issensis, sp. nov., isolated from various quarters of the International Space Station

As part of an ongoing effort to catalogue microbial communities inhabiting the International Space Station (ISS) crew-associated environmental samples were collected from the Japanese Kibo Russian and US research modules. Initial analysis based on 16S rRNA gene sequencing identified 11 Bacillus isolates (two from Kibo Japanese Experiment Module (JEM) four from US Segment Harmony Node 2 and five from Russian Segment Zvezda module sites) all belonging to the Bacillus anthracis-B. cereus-B. thuringiensis group. Isolates were further characterized by whole genome comparative analysis. Each isolate was sequenced assembled and aligned against all members of the B. cereus sensu lato group. Based on genome size estimates (5.2 - 5.3 Mbp) strain nucleotide identity (>99.99%) and maximum likelihood phylogenetic placement all isolates were found to exhibit a very high level of similarity. With respect to gene content all isolates were inspected for cry proteins common to B. thuringiensis as well as toxins specific to B. cereus. No significant hits were found to any known cry genes while full-length matches were found for multiple B. cereus toxin genes. Finally the isolates were closely screened against B. anthracis genomes and no B. anthracis signatures were identified. Notably all isolates contained the plcR ancestral C allele and lacked significant hits to pXO1 and pXO2 plasmids and toxins. The collective results from the analysis confirm that these strains belong to a previously uncharacterized Bacillus species hereafter referred to as Bacillus issensis. The type strain is ISSFR-003T (=NRRL B-65389T= DSMZ 101676T).

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Organization: National Aeronautics and Space Administration
NEAR SPICE KERNELS V1.0

This data set includes the complete set of NEAR SPICE data files (``kernel files''), which can be accessed using SPICE software. The SPICE data contain geometric and other ancillary information needed to recover the full value of science instrument data. In particular SPICE kernels provide spacecraft and planetary ephemerides, instrument mounting alignments, spacecraft orientation, and data needed for relevant time conversions.

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Organization: National Aeronautics and Space Administration
Rodent Research-1 (RR1) NASA Validation Flight: Mouse tibialis anterior muscle transcriptomic, proteomic, and epigenomic data

NASA's Rodent Research (RR) project is playing a critical role in advancing biomedical research on the physiological effects of space environments. Due to the limited resources for conducting biological experiments aboard the International Space Station (ISS), it is imperative to use crew time efficiently while maximizing high-quality science return. NASA's GeneLab project has as its primary objectives to 1) further increase the value of these experiments using a multi-omics, systems biology-based approach, and 2) disseminate these data without restrictions to the scientific community. The current investigation assessed viability of RNA, DNA, and protein extracted from archived RR-1 tissue samples for epigenomic, transcriptomic, and proteomic assays. During the first RR spaceflight experiment, a variety of tissue types were harvested from subjects, snap-frozen or RNAlater-preserved, and then stored at least a year at -80C after return to Earth. They were then prioritized for this investigation based on likelihood of significant scientific value for spaceflight research. All tissues were made available to GeneLab through the bio-specimen sharing program managed by the Ames Life Science Data Archive and included mouse adrenal glands, quadriceps, gastrocnemius, tibialis anterior, extensor digitorum longus, soleus, eye, and kidney. We report here protocols for and results of these tissue extractions, and thus, the feasibility and value of these kinds of omics analyses. In addition to providing additional opportunities for investigation of spaceflight effects on the mouse transcriptome and proteome in new kinds of tissues, our results may also be of value to program managers for the prioritization of ISS crew time for rodent research activities.

Tags: __
Organization: National Aeronautics and Space Administration
ROSETTA-ORBITER 67P OSIWAC 4 EXT2-MTP029 RDR-REFLECT V1.0

This CODMAC level 4 data set contains radiometric calibrated and geometric distortion corrected (resampled) image data in reflectance units (normalized and thus without unit), acquired by the OSIRIS Wide Angle Camera on the Rosetta spacecraft during the ROSETTA EXTENSION 2 mission phase, covering the period from 2016-05-03T23:25:00.000 to 2016-05-31T23:24:59.000. The prime target is comet 67P/Churyumov-Gerasimenko 1 (1969 R1). This version V1.0 is the first version of this dataset: Lien corrected dataset after October 2018 PSA/PDS external peer review.

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Organization: National Aeronautics and Space Administration
MIT/Amsterdam M 31 Survey

The MIT/Amsterdam M 31 Survey, or the Extended Magnier et al. Catalog of Objects in the Field of M 31, is based on deep BVRI CCD photometry that was performed on a 1 square degree region of M 31. The observations were made between September 12 and September 27 1990, using the McGraw-Hill 1.3m telescope at the Michigan-Dartmouth-MIT (MDM) observatory at Kitt Peak. The catalogue has typical completeness limits of 20.7 (Bmag), 21.7 (Vmag), 20.2 (Rmag) and 20.5 (Imag), although there is a large region in the inner disk for which the completeness limits are substantially deeper: 22.3 (Bmag), 22.2 (Vmag), 22.2 (Rmag), and 20.9 (Imag). The photometric accuracy is about 2% at Vmag = 19. The final astrometric calibrations take into account the systematic error discovered in the Berkhuijsen et al. (1988, A&amp;AS, 76, 65) catalog by Magnier et al. (1993, A&amp;A, 272, 695). They are in the J2000 system and are eventually tied to the HST Guide Star Catalog. The final photometric calibrations are tied via the NGC 206 region to photometry taken at the Michigan-Dartmouth-MIT (MDM) 1.3m in September and October 1993. These are tied to the Landolt (1992, AJ, 104, 340) system of standard stars, and are in the Johnson-Kron-Cousins system (BVRcIc). This version of the MIT/Amsterdam M31 Survey Catalog was created at the HEASARC in March 1999 based on the CDS/ADC Catalogue II/208. The HEASARC revised this version in February 2001. This is a service provided by NASA HEASARC .

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Organization: National Aeronautics and Space Administration
A Molecular Genetic Basis Explaining Altered Bacterial Behavior in Space

Bacterial behavior has been observed to change during spaceflight. Higher final cell counts, enhanced biofilm formation, increased virulence, and reduced susceptibility to antibiotics have been reported to occur for cells cultured in space . Most of these phenomena are theorized as being an indirect effect of an altered extracellular environment, where the carbon source uptake is inhibited and excreted acidic byproducts buildup around the cell due to the lack of gravity-driven transport forces. However, to date neither spaceflight results, ground-based studies, physical measurement techniques nor computational approaches have provided sufficient evidence needed to confirm this model. Gene expression data from the Antibiotic Effectiveness in Space (AES-1) experiment, however, have now allowed us to look into the biomolecular processes behind these observations and showed a systematic activation of glucose starvation and acid resistance genes. These results corroborate the reduced mass transport model proposed to govern bacterial responses to spaceflight. Furthermore, the gene expression data suggests that metabolism was stimulated in space, which could play a role in causing the observed increase in bacterial cell concentrations in microgravity. Similarly, the decrease in extracellular pH may also be involved with the reported increase in virulence in space.

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Organization: National Aeronautics and Space Administration
Evaluation of in vitro macrophage differentiation during space flight

We differentiated mouse bone marrow cells in the presence of recombinant macrophage colony stimulating (rM-CSF) factor for 14 days during the flight of space shuttle Space Transportation System (STS)-126. We tested the hypothesis that the receptor expression for M-CSF, c-Fms was reduced. We used flow cytometry to assess molecules on cells that were preserved during flight to define the differentiation state of the developing bone marrow macrophages; including CD11b, CD31, CD44, Ly6C, Ly6G, F4/80, Mac2, c-Fos as well as c-Fms. In addition, RNA was preserved during the flight and was used to perform a gene microarray. We found that there were significant differences in the number of macrophages that developed in space compared to controls maintained on Earth. We found that there were significant changes in the distribution of cells that expressed CD11b, CD31, F4/80, Mac2, Ly6C and c-Fos. However, there were no changes in c-Fms expression and no consistent pattern of advanced or retarded differentiation during space flight. We also found a pattern of transcript levels that would be consistent with a relatively normal differentiation outcome but increased proliferation by the bone marrow macrophages that were assayed after 14 days of space flight. There also was a surprising pattern of space flight influence on genes of the coagulation pathway. These data confirm that a space flight can have an impact on the in vitro development of macrophages from mouse bone marrow cells.

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Organization: National Aeronautics and Space Administration
ROSETTA-ORBITER 67P RPCLAP 5ESC3 NEL V1.0

This data set contains DERIVEDdata from Rosetta RPC-LAP, acquired during the COMET ESCORT 3 missionphase where the primary target was the comet 67P/CHURYUMOV-GERASIMENKO 1(1969 R1). It contains electron density at higher time resolution thanin the DERIV2 data sets.

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Organization: National Aeronautics and Space Administration
BAX X-Ray Galaxy Clusters and Groups Catalog

This table contains the BAX X-Ray Galaxy Clusters and Groups Catalog. BAX (`Base de Donnees Amas de Galaxies X&#39;: see &lt;a href="http://bax.ast.obs-mip.fr/"&gt;http://bax.ast.obs-mip.fr/&lt;/a&gt; for more details) is a multi-wavelength database dedicated to X-ray clusters and groups of galaxies which allows detailed information retrieval. BAX is designed to support astronomical research by providing access to published measurements of the main physical quantities and to the related bibliographic references: basic data stored in the database are cluster/group identifiers, equatorial coordinates, redshift, flux, X-ray luminosity (in the ROSAT band) and temperature, and (in the online version at &lt;a href="http://bax.ast.obs-mip.fr/"&gt;http://bax.ast.obs-mip.fr/&lt;/a&gt;) links to additional linked parameters (in X-rays, such as spatial profile parameters, as well as SZ parameters of the hot gas, lensing measurements, and data at other wavelengths, such as the optical and radio bands). The clusters and groups in the online BAX database can be queried by the basic parameters as well as the linked parameters or combinations of these. The authors expect BAX to become an important tool for the astronomical community. BAX will optimize various aspects of the scientific analysis of X-ray clusters and groups of galaxies, from proposal planning to data collection, interpretation and publication, from both ground based facilities like MEGACAM (CFHT), VIRMOS (VLT) and from space missions like XMM-Newton, Chandra and Planck. This table was created by the HEASARC in October 2004 based on CDS table B/bax/bax.dat. This is a service provided by NASA HEASARC .

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Organization: National Aeronautics and Space Administration