AndreaBozzo/ceres-open-data-index huggingface dataset:
Compound 525111: 2,3-Dichloropropyl nonanoate

Chemical compound data from PubChem database. IUPAC Name: 2,3-dichloropropyl nonanoate. Molecular Formula: C12H22Cl2O2. Molecular Weight: 269.2. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2022 Uniform Reporting System (URS) Table For South Carolina

This is the 2022 Uniform Reporting System (URS) Output Tables for South Carolina. The URS state reporting system is collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: mental-health-services, national-outcome-measures, samhsa, south-carolina, substance-abuse
Organization: U.S. Department of Health & Human Services
Minnesota (MN)

This report uses 2008 to 2010 National Survey on Drug Use and Health (NSDUH) to assess past year alcohol use disorder and illicit drug use disorder among persons aged 12 or older for Minnesota overall and for substate regions within Minnesota. Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE).

Tags: alcohol-use-disorder, illicit-drug-use, mental-health-indicators, samhsa, substance-use-disorder
Organization: U.S. Department of Health & Human Services
Dengue fever in pregnancy: a case report

Background
          Dengue, a mosquito-borne flavivirus infection, is endemic in Southeast Asia. Currently, the incidence has been increasing among adults.
        
        
          Case presentation
          A 26-year-old Thai woman, G1P0 31 weeks pregnancy, presented with epigastric pain for 1 day. She also had a high-grade fever for 4 days. The physical examination, complete blood counts as well as serology confirmed dengue fever. The patient was under conservative treatment despite severe thrombocytopenia. She was well at the 3rd day of discharge and 1-week follow-up. The pregnancy continued until term without any complication and she delivered vaginally a healthy female baby.
        
        
          Conclusions
          More cases of dengue infection in pregnancy can be found due to the increasing incidence during adulthood. It should be suspected when a pregnant woman presents with symptoms and signs like in a non-pregnant. Conservative treatment should be conducted unless there are any complications.

Tags: case-report, dengue-fever, nih, pregnancy-complications, thrombocytopenia
Organization: U.S. Department of Health & Human Services
Compound 525252: N''-(4-nitro-phenyl)-N,N,N',N'-tetramethyl-guanidine

Chemical compound data from PubChem database. IUPAC Name: 1,1,3,3-tetramethyl-2-(4-nitrophenyl)guanidine. Molecular Formula: C11H16N4O2. Molecular Weight: 236.27. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Mississippi (MS)

This report presents Mississippi\'s estimates for 25 measures of substance use and mental health based on the combined 2009 and 2010 National Surveys on Drug Use and Health (NSDUHs). Topics covered include past month substance use (e.g., illicit drugs, marijuana, cocaine, pain relievers, alcohol, tobacco), substance dependence, abuse, and treatment need, past year serious mental illness (SMI), any mental illness (AMI), suicidal thoughts, and major depressive episode (MDE). Resuts are provided for Mississippi for five age groups: 12 to 17, 18 to 25, 26 or older, 18 or older and all persons 12 or older.

Tags: mental-health, mississippi-health, national-survey, samhsa, substance-use
Organization: U.S. Department of Health & Human Services
Compound 525115: 3-Chloropropyl heptanoate

Chemical compound data from PubChem database. IUPAC Name: 3-chloropropyl heptanoate. Molecular Formula: C10H19ClO2. Molecular Weight: 206.71. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
2012 Uniform Reporting System (URS) Tables for Delaware

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2012. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, delaware-mental-health, mental-health-services, national-outcome-measures, samhsa
Organization: U.S. Department of Health & Human Services
Hispanic Subgroups Differ in Rates of Substance Use Treatment Need and Receipt (2004 to 2011 NSDUH)

This report uses combined 2004 to 2011 National Survey on Drug Use and Health (NSDUH) to assess past year need for and receipt of substance use treatment among Hispanics aged 12 or older. Results are shown by Hispanic subgroups.

Tags: hispanic-subgroups, nsduh-data, samhsa, substance-use-treatment, treatment-need
Organization: U.S. Department of Health & Human Services
National Directory of Drug and Alcohol Abuse Treatment Facilities 2001

The National Directory of Drug and Alcohol Abuse Treatment Programs 2001 lists federal, state, local, and private facilities that provide substance abuse treatment services. The directory includes treatment facilities that are licensed, certified, or otherwise approved for inclusion in the directory by their state substance abuse agencies and that responded to the 2000 National Survey of Substance Abuse Treatment Services (N-SSATS). The information about each facility that appears in this directory was provided by that facility in response to the 2000 N-SSATS. The Substance Abuse and Mental Health Services Administration (SAMHSA) conducts the N-SSATS annually.

Tags: alcohol-abuse-treatment, n-ssats, samhsa, substance-abuse-treatment, treatment-facility-directory
Organization: U.S. Department of Health & Human Services
2016 Sample Experience Report

The goal of this report is to further document the 2016 NSDUH sample experiences, including a comparison of actual sample yields to state and quarter targets, a comparison of achieved and expected design effects (DEFFs) and relative standard errors (RSEs), and documentation of any issues encountered during sample implementation (none in 2016).

Tags: design-effects, nsduh, relative-standard-errors, samhsa, sample-yield
Organization: U.S. Department of Health & Human Services
The Myocardial Ischemia Reduction with Acute Cholesterol Lowering trial: MIRACuLous or not, it's time to change current practice

The Myocardial Ischemia Reduction with Aggressive Cholesterol Lowering (MIRACL) study was the first trial to assess whether statins might be of clinical benefit in those with recently unstable coronary disease. MIRACL found that high-dose atorvastatin was safe and reduced the incidence of the composite endpoint, death, non-fatal myocardial infarction, resuscitated sudden cardiac death or emergent rehospitalization for recurrent ischemia at 16 weeks when compared with placebo. Despite a number of important study limitations, MIRACL's findings and the prior observation that inpatient initiation of lipid-lowering therapy is associated with higher rates of subsequent utilization, suggest that it is prudent to begin statin therapy when patients present with an acute coronary syndrome.

Tags: acute-coronary-syndrome, atorvastatin, myocardial-ischemia, nih, statin-therapy
Organization: U.S. Department of Health & Human Services
Second National Juvenile Online Victimization Study (NJOV-2)

The Second National Juvenile Online Victimization Study (NJOV-2) was conducted in 2007-2008 and designed to update and expand upon the First National Juvenile Online Victimization Study (NJOV-1) conducted in 2001-2002. Researchers collected information from a national sample of more than 2,500 law enforcement agencies about Internet sex crimes against minors during 2006, providing detailed information about the types of Internet sex crimes, as well as numbers of arrests, characteristics of offenders and victims, dynamics of the crimes, and criminal justice system responses. Data, which are weighted to provide national estimates, were collected via mail surveys followed by telephone interviews with investigators about specific cases reported in the mail surveys.

Investigators: Finkelhor, D., Mitchell, K., & Wolak, J.

Tags: abuse, care, ndacan, policy, reporting
Organization: U.S. Department of Health & Human Services
New York City – 5 Boros: Drug-Related Emergency Department Visits, 2004-2011 - Accidental Ingestions

Excel file with estimates, rates, relative standard errors, trends and confidence intervals, covering 2004-2011 for emergency department visits involving accidental ingestions in New York City (5 boroughs). This analytic category includes ED visits in which an individual accidentally or unknowingly used or was administered a prescription drug, over-the-counter medication, or dietary supplement. Drug-related accidental ingestion typically involves patients aged 5 and under.  This analytic category does not include drug misuse or abuse.File includes data for over 500 drugs, including illicit drugs, prescription and over-the-counter medications, dietary supplements, inhalants and alcohol.  Includes total visits, gender, age group, race/ethnicity, outcome of visit, drug combinations, number of drugs involved in visit, drug frequency, and drugs confirmed by toxicology.Additional detail is provided for illicit drugs, psychotherapeutic drugs, central nervous system (CNS) drugs, respiratory drugs and cardiovascular drugs.

Tags: accidental-ingestion, drug-related-visits, emergency-department, pediatric-poisoning, samhsa
Organization: U.S. Department of Health & Human Services
Compound 525149: Dipropylene glycol, monoallyl ether, acetate

Chemical compound data from PubChem database. IUPAC Name: 2-(2-prop-2-enoxypropoxy)propyl acetate. Molecular Formula: C11H20O4. Molecular Weight: 216.27. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Phylogenetic relationships between

Background
          Phylogenetic relationships of the genus Hapalemur remains controversial, particularly within the Hapalemur griseus species group. In order to obtain more information on the taxonomic status within this genus, and particularly in the cytogenetic distinct subspecies group of Hapalemur griseus, 357 bp sequence of cytochrome b and 438 bp of 12S mitochondrial DNAs were analyzed on a sample of animals captured in areas extending from the north to the south-east of Madagascar. This sample covers all cytogenetically defined types recognized of the genus Hapalemur.
        
        
          Results
          Phylogenetic trees and distances analyses demonstrate a first emergence of Hapalemur simus followed by H. aureus which is the sister clade of the H. griseus subspecies. Hapalemur griseus is composed of 4 subspecies separated into two clades. The first contains H. g. griseus, H. g. alaotrensis and H. g. occidentalis. The second consists of H. g. meridionalis. A new chromosomal polymorphic variant from the region of Ranomafana, H. griseus ssp, has been analysed and was found in both clades.
        
        
          Conclusions
          Our results support the raising of H. g. meridionalis to the specific rank H. meridionalis, while neither cytogenetic nor molecular evidences support the raising of H. g. alaotrensis to a species rank despite its morphological characteristics. The new cytotype H. g. ssp which has been previously characterized by cytogenetic studies contains animals clustering either with the group of Hapalemur griseus griseus or with that of Hapalemur meridionalis. This suggests the existence of an ancestral polymorphism or an introgression of mitochondrial DNA between subspecies.

Tags: hapalemur-phylogeny, mitochondrial-dna, nih, primate-genetics, species-classification
Organization: U.S. Department of Health & Human Services
Compound 525245: N''-(4-bromo-phenyl)-N,N,N',N'-tetramethyl-guanidine

Chemical compound data from PubChem database. IUPAC Name: 2-(4-bromophenyl)-1,1,3,3-tetramethylguanidine. Molecular Formula: C11H16BrN3. Molecular Weight: 270.17. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.

Tags: chemistry, compound, pubchem, research, science
Organization: U.S. Department of Health & Human Services
Publications Using SAMHSA Data2008 CMHS Uniform Reporting System Output Tables

Center for Mental Health Services (CMHS) Uniform Reporting System (URS) Output Tables for 2008. The Uniform Reporting System (URS) is a state and national reporting system collected annually to support the Community Mental Health Services Block Grant program. State Mental Health Authorities report on National Outcome Measures (NOMS), evidence-based practices, and utilization measures providing an overview of state mental health delivery systems.

Tags: community-mental-health, mental-health-services, national-outcome-measures, samhsa, urs-data
Organization: U.S. Department of Health & Human Services
Glycogen synthase kinase3 beta phosphorylates serine 33 of p53 and activates p53's transcriptional activity

Background
          The p53 protein is activated by genotoxic stress, oncogene expression and during senescence, p53 transcriptionally activates genes involved in growth arrest and apoptosis. p53 activation is regulated by post-translational modification, including phosphorylation of the N-terminal transactivation domain. Here, we have examined how Glycogen Synthase Kinase (GSK3), a protein kinase involved in tumorigenesis, differentiation and apoptosis, phosphorylates and regulates p53.
        
        
          Results
          The 2 isoforms of GSK3, GSK3α and GSK3β, phosphorylate the sequence Ser-X-X-X-Ser(P) when the C-terminal serine residue is already phosphorylated. Several p53 kinases were examined for their ability to create GSK3 phosphorylation sites on the p53 protein. Our results demonstrate that phosphorylation of serine 37 of p53 by DNA-PK creates a site for GSK3β phosphorylation at serine 33 in vitro. GSK3α did not phosphorylate p53 under any condition. GSK3β increased the transcriptional activity of the p53 protein in vivo. Mutation of either serine 33 or serine 37 of p53 to alanine blocked the ability of GSK3β to regulate p53 transcriptional activity. GSK3β is therefore able to regulate p53 function in vivo. p53's transcriptional activity is commonly increased by DNA damage. However, GSK3β kinase activity was inhibited in response to DNA damage, suggesting that GSK3β regulation of p53 is not involved in the p53-DNA damage response.
        
        
          Conclusions
          GSK3β can regulate p53's transcriptional activity by phosphorylating serine 33. However, GSK3β does not appear to be part of the p53-DNA damage response pathway. Instead, GSK3β may provide the link between p53 and non-DNA damage mechanisms for p53 activation.

Tags: dna-pk, gsk3-beta, nih, p53-phosphorylation, tumor-suppressor
Organization: U.S. Department of Health & Human Services
Are the pneumococcal polysaccharide vaccines effective? Meta-analysis of the prospective trials

The objective was to review the evidence of effectiveness of the polyvalent polysaccharide pneumococcal vaccine from prospective properly randomised controlled trials comparing pneumococcal vaccines with placebo in subjects who are immunocompetent and those likely to have an impaired immune system.
        Databases searched included the Cochrane Library, (issue 2, 2000), MEDLINE (1966-August 2000), PubMed (to August 2000) and EMBASE ( to August 2000). Reference lists of reports and reviews were also searched. To be included in the analysis, a study had to have been a prospective randomised comparison of a polysaccharide pneumococcal vaccine (any valency) and to have a placebo or no treatment comparison group. Papers had to report important clinical outcomes, such as rates of pneumonia, pneumococcal pneumonia, lower respiratory tract infections, pneumonia deaths or bacteraemia. Serological outcomes were not sought. 
        Thirteen randomised comparisons with over 45,000 subjects were identified in an extensive literature review. Eight studies had a quality score of 3 or more on a scale of 1 to 5. In three comparisons with 21,152 immunocompetent subjects (South African gold miners, New Guinea highlanders) pneumococcal vaccination was effective in reducing the incidence of all-cause pneumonia (relative risk 0.56, 95% confidence interval 0.47 to 0.66), pneumococcal pneumonia (0.16; 0.11 to 0.23), pneumonia deaths (0.70; 0.50 to 0.96) and bacteraemia (0.18; 0.09 to 0.34). In ten comparisons in over 24,000 people who were elderly or likely to have impaired immune systems, pneumococcal vaccination was without effect for any outcome.
        Present guidelines recommend pneumococcal vaccination for "high-risk" groups. There is no evidence from randomised trials that this is of any benefit.

Tags: meta-analysis, nih, pneumococcal-vaccine, pneumonia-prevention, vaccine-effectiveness
Organization: U.S. Department of Health & Human Services
2012-2014 NSDUH State-Specific Substate Region Estimates and Maps

This report provides a guide to the development and presentation of 2012-2014 NSDUH substate estimates. A summary of the estimation methodology is included as well as sample sizes, response rates, and population estimates.

Tags: mental-health, samhsa, state-estimates, substance-use, survey-data
Organization: U.S. Department of Health & Human Services
Denver: Drug-Related Emergency Department Visits, 2004-2011 - Nonmedical Use of Pharmaceuticals

Excel file with estimates, rates, relative standard errors, trends and confidence intervals for all drug-related emergency department (ED) visits involving the nonmedical use of pharmaceuticals (prescription and over-the-counter medications and dietary supplements) for the Denver metropolitan area, covering 2004-2011.  Nonmedical use includes patients who took a higher than prescribed or recommended dose of their own medication, patients who took a pharmaceutical prescribed for another person, malicious poisoning of the patient by another individual, and documented substance abuse involving pharmaceuticals

Tags: denver-metro-area, drug-related-ed, emergency-department-visits, pharmaceutical-misuse, samhsa
Organization: U.S. Department of Health & Human Services
Genomic organization of

Background
          The tropomodulins (TMODs) are a family of proteins that cap the pointed ends of actin filaments. Four TMODs have been identified in humans, with orthologs in mice. Mutations in actin or actin-binding proteins have been found to cause several human diseases, ranging from hypertrophic cardiomyopathy to immunodefiencies such as Wiskott-Aldrich syndrome. We had previously mapped Tropomodulin 2 (TMOD2) to the genomic region containing the gene for amyotrophic lateral sclerosis 5 (ALS5). We determined the genomic structure of Tmod2 in order to better analyze patient DNA for mutations; we also determined the genomic structure of Tropomodulin 4 (TMOD4).
        
        
          Results
          In this study, we determined the genomic structure of TMOD2 and TMOD4 and found the organization of both genes to be similar. Sequence analysis of TMOD2 revealed no mutations or polymorphisms in ALS5 patients or controls. Interestingly, we discovered that another gene, YL-1, intergenically splices into TMOD4. YL-1 encodes six exons, the last of which is 291 bp from a 5' untranslated exon of TMOD4. We used 5' RACE and RT-PCR from TMOD4 to identify several intergenic RACE products. YL-1 was also found to undergo unconventional splicing using non-canonical splice sites within exons (intraexonic splicing) to produce several alternative transcripts.
        
        
          Conclusions
          The genomic structure of TMOD2 and TMOD4 have been delineated. This should facilitate future mutational analysis of these genes. In addition, intergenic splicing at TMOD4/YL-1 was discovered, demonstrating yet another level of complexity of gene organization and regulation.

Tags: actin-filaments, gene-structure, nih, tmod2-tmod4, tropomodulins
Organization: U.S. Department of Health & Human Services
Physiologic role of interleukin-1 receptor antagonist

Recent studies have described the spontaneous development of			 arthritis or vasculitis in IL-1 receptor antagonist (IL-1Ra) knockout mice bred			 on specific and different genetic backgrounds. The levels of both secreted and			 intracellular isoforms of IL-1Ra produced in the rheumatoid joint or in the			 arterial wall may not be adequate to effectively inhibit the excess amounts of			 locally produced IL-1. Thus, an imbalance between IL-1 and IL-1Ra may			 predispose to local inflammatory disease in particular tissues in the presence			 of other as yet unknown genetically influenced factors.

Tags: cytokine-research, il-1ra, nih, rheumatoid-arthritis, vasculitis
Organization: U.S. Department of Health & Human Services
Detection and characterization of the

Background
          Virulence genes on Salmonella pathogenicity island 1 (SPI1) are coordinately regulated by HilA, a member of the OmpR/ToxR family of transcription factors. Although a great deal is known about the complex regulation of hilA gene expression, very little is known about the HilA protein.
        
        
          Results
          In order to detect and localize the HilA protein in S. typhimurium, we raised polyclonal antiserum against purified His-tagged HilA. This allowed us to study the effect of environmental conditions on the production of HilA. We also used the antiserum to examine the fractionation properties and SDS-PAGE mobility of native HilA. Our results indicate that S. typhimurium initiates translation of HilA from the first AUG codon in the hilA open-reading frame (ORF), producing a soluble 553 amino acid (63 kDa) protein product.
        
        
          Conclusion
          Materials and methods are now available to study the environmental regulation of the HilA protein in S. typhimurium. Our results also indicate that future in vitro studies of the interaction between HilA and DNA should utilize soluble preparations of HilA. Previous analyses used preparations of HilA in which the protein fractionated with the membrane, greatly limiting the types of experiments that could be conducted.

Tags: hila-protein, nih, salmonella, salmonella-typhimurium, virulence-genes
Organization: U.S. Department of Health & Human Services