Haram Drugs
There is one point. A person develops an immunity towards the effect of the thing one is consuming. Like a regular smoker wont feel much but if a non smoker smokes a cigarette or tobacco in some other form will have an effect and experience some sort of a high. If things are to be considered intoxicants in terms of qiyas than substances like marijuana etc which have a little effect on regular smokers become debatable. As they normally say that it has become quite similar to a cigarette for us.