AIM-Harvard/TrialPanorama-filtered huggingface dataset:
Drug: azapetine
Target: Adrenergic receptor alpha-1 (GPCR)
Gene: Adra1b|Adra1d|Adra1a
UniProt: P15823|P23944|P43140 (ADA1B_RAT|ADA1D_RAT|ADA1A_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 6.69
Assay: Inhibition of specific [3H]-prazosin binding (0.2 nM) to rat brain membranes alpha-1 adrenergic receptor
Drug: azapropazone
Target: Prostaglandin G/H synthase 1 (Enzyme)
Gene: PTGS1
UniProt: P23219 (PGH1_HUMAN)
Organism: Homo sapiens
Drug: azapropazone
Target: Xanthine dehydrogenase/oxidase (Enzyme)
Gene: XDH
UniProt: P47989 (XDH_HUMAN)
Organism: Homo sapiens
Drug: azasetron
Target: 5-hydroxytryptamine receptor 3A (Ion channel)
Gene: HTR3A
UniProt: P46098 (5HT3A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 9.268
Action type: ANTAGONIST
Drug: azatadine
Target: Histamine H1 receptor (GPCR)
Gene: HRH1
UniProt: P35367 (HRH1_HUMAN)
Organism: Homo sapiens
Action type: ANTAGONIST
Drug: azatadine
Target: Histamine H1 receptor (GPCR)
Gene: Hrh1
UniProt: P31390 (HRH1_RAT)
Organism: Rattus norvegicus
Activity: Ki = 8.41
Assay: Binding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligand
Drug: azathioprine
Target: ATP-binding cassette sub-family G member 2 (Transporter)
Gene: ABCG2
UniProt: Q9UNQ0 (ABCG2_HUMAN)
Organism: Homo sapiens
Drug: azathioprine
Target: Multidrug resistance-associated protein 5 (Transporter)
Gene: ABCC5
UniProt: O15440 (MRP5_HUMAN)
Organism: Homo sapiens
Drug: azathioprine
Target: Multidrug resistance-associated protein 4 (Transporter)
Gene: ABCC4
UniProt: O15439 (MRP4_HUMAN)
Organism: Homo sapiens
Drug: azathioprine
Target: Ras-related C3 botulinum toxin substrate 1 (Enzyme)
Gene: RAC1
UniProt: P63000 (RAC1_HUMAN)
Organism: Homo sapiens
Drug: azathioprine
Target: Thiopurine S-methyltransferase (Enzyme)
Gene: TPMT
UniProt: P51580 (TPMT_HUMAN)
Organism: Homo sapiens
Drug: azelaic acid
Target: 3-oxo-5-alpha-steroid 4-dehydrogenase 2 (Enzyme)
Gene: SRD5A2
UniProt: P31213 (S5A2_HUMAN)
Organism: Homo sapiens
Drug: azelastine
Target: Potassium voltage-gated channel subfamily H member 2 (Ion channel)
Gene: KCNH2
UniProt: Q12809 (KCNH2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7
Assay: Displacement of labeled dofetilide human ERG
Drug: azelastine
Target: Multidrug resistance protein 1 (Transporter)
Gene: ABCB1
UniProt: P08183 (MDR1_HUMAN)
Organism: Homo sapiens
Drug: azelastine
Target: 5-hydroxytryptamine receptor 2B (GPCR)
Gene: HTR2B
UniProt: P41595 (5HT2B_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.7
Assay: Displacement of [3H]mesulergine from recombinant human 5-ht2B expressed in CHO cells
Drug: azelastine
Target: 5-hydroxytryptamine receptor 2C (GPCR)
Gene: HTR2C
UniProt: P28335 (5HT2C_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.3
Assay: Displacement of [3H]mesulergine from recombinant human 5-ht2C expressed in CHO cells
Drug: azelastine
Target: Alpha-1A adrenergic receptor (GPCR)
Gene: ADRA1A
UniProt: P35348 (ADA1A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.3
Assay: Binding affinity to human adrenergic alpha1A receptor expressed in rat intact fibroblasts
Drug: azelastine
Target: Histamine H1 receptor (GPCR)
Gene: HRH1
UniProt: P35367 (HRH1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.168
Action type: ANTAGONIST
Drug: azelastine
Target: Muscarinic acetylcholine receptor M1 (GPCR)
Gene: CHRM1
UniProt: P11229 (ACM1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.2
Assay: Displacement of [3H]AF-DX 384 from recombinant human M1 receptor expressed in CHO cells
Drug: azelastine
Target: Alpha-1B adrenergic receptor (GPCR)
Gene: ADRA1B
UniProt: P35368 (ADA1B_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.3
Assay: Binding affinity to human adrenergic Alpha-1B receptor expressed in rat intact fibroblasts
Drug: azelastine
Target: Histamine H3 receptor (GPCR)
Gene: HRH3
UniProt: Q9Y5N1 (HRH3_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.83
Assay: Antagonist activity at human H3 receptor expressed in CHO cells assessed as inhibition of histamine-induced GTPgamma[S] binding by scintillation proximity assay
Drug: azelastine
Target: Alpha-1A adrenergic receptor (GPCR)
Gene: Adra1a
UniProt: P43140 (ADA1A_RAT)
Organism: Rattus norvegicus
Activity: Ki = 7.3
Assay: Displacement of [3H]prazosin from rat salivary gland adrenergic alpha1a receptor
Drug: azelnidipine
Target: Voltage-gated L-type calcium channel (Ion channel)
Gene: CACNA1D|CACNA1C
UniProt: Q01668|Q13936 (CAC1D_HUMAN|CAC1C_HUMAN)
Organism: Homo sapiens
Action type: BLOCKER
Assay: Mechanism of Action
Drug: azimilide
Target: Potassium voltage-gated channel subfamily H member 2 (Ion channel)
Gene: KCNH2
UniProt: Q12809 (KCNH2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.4
Assay: Inhibitory concentration against IKr potassium channel
Drug: azimilide
Target: Potassium voltage-gated channel subfamily H member 2 (Ion channel)
Gene: KCNH2
UniProt: O08703 (KCNH2_CAVPO)
Organism: Cavia porcellus
Activity: IC50 = 6.74
Assay: Inhibition of ERG in guinea pig ventricular myocytes assessed as blockade of rapid delayed rectifier potassium current by whole cell patch-clamp technique
Drug: azimilide
Target: Potassium voltage-gated channel subfamily KQT member 1 (Ion channel)
Gene: KCNQ1
UniProt: O70344 (KCNQ1_CAVPO)
Organism: Cavia porcellus
Activity: IC50 = 6.62
Assay: Inhibition of KVLQT1/minK in guinea pig ventricular myocytes assessed as blockade of slow delayed rectifier potassium current by whole cell patch-clamp technique
Drug: azimilide
Target: Potassium voltage-gated channel subfamily KQT member 1 (Ion channel)
Gene: Kcnq1
UniProt: P97414 (KCNQ1_MOUSE)
Organism: Mus musculus
Activity: IC50 = 5.3
Action type: BLOCKER
Drug: azithromycin
Target: Potassium voltage-gated channel subfamily H member 2 (Ion channel)
Gene: KCNH2
UniProt: Q12809 (KCNH2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 3.39
Drug: azithromycin
Target: Multidrug resistance protein 1 (Transporter)
Gene: ABCB1
UniProt: P08183 (MDR1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 3.7
Drug: azithromycin
Target: Canalicular multispecific organic anion transporter 1 (Transporter)
Gene: ABCC2
UniProt: Q92887 (MRP2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.16
Drug: azithromycin
Target: Motilin receptor (GPCR)
Gene: MLNR
UniProt: O43193 (MTLR_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 5.5
Action type: AGONIST
Drug: azlocillin
Target: Penicillin-binding protein (Enzyme)
Gene: mrcA|pbpB|pbpC|pbpA|dacA|ponB
UniProt: Q07806|Q51504|Q51505|Q9X6V3|Q9X6V7|Q9X6W0 (PBPA_PSEAE|Q51504_PSEAI|Q51505_PSEAI|Q9X6V3_PSEAI|Q9X6V7_PSEAI|Q9X6W0_PSEAI)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Action type: INHIBITOR
Assay: Mechanism of Action; CHEMBL2363020; PROTEIN FAMILY
Drug: aztreonam
Target: Peptidoglycan synthase FtsI (Enzyme)
Gene: ftsI
UniProt: P0AD68 (FTSI_ECOLI)
Organism: Escherichia coli (strain K12)
Activity: IC50 = 5.736
Action type: INHIBITOR
Drug: aztreonam
Target: Penicillin-binding protein 1A (Enzyme)
Gene: mrcA
UniProt: Q07806 (PBPA_PSEAE)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Activity: IC50 = 5.48
Assay: Displacement of fluorescent Bocillin FL from N-terminal His tagged Pseudomonas aeruginosa PAO1 PBP1a (residues 36 to 822) expressed in Escherichia coli BL21 (Gold cells)
Drug: aztreonam
Target: Penicillin-binding protein 1A (Enzyme)
Gene: mrcA
UniProt: P02918 (PBPA_ECOLI)
Organism: Escherichia coli (strain K12)
Activity: IC50 = 5.317
Action type: INHIBITOR
Drug: aztreonam
Target: Penicillin-binding protein 1B (Enzyme)
Gene: mrcB
UniProt: P02919 (PBPB_ECOLI)
Organism: Escherichia coli (strain K12)
Activity: IC50 = 4.317
Action type: INHIBITOR
Drug: aztreonam
Target: Beta-lactamase (Enzyme)
Gene: blaPER-2
UniProt: A2RP81 (A2RP81_CITFR)
Organism: Citrobacter freundii
Activity: Ki = 5.7
Assay: Inhibition of Citrobacter freundii PER2 beta lactamase
Drug: aztreonam
Target: Beta-lactamase (Enzyme)
Gene: blaACC-4
UniProt: A4ZYU9 (A4ZYU9_ECOLX)
Organism: Escherichia coli
Activity: IC50 = 7.49
Assay: Inhibition of Escherichia coli beta-lactamase ACC4
Drug: aztreonam
Target: AmpC (Unclassified)
Gene: ampC
UniProt: Q83TT7 (Q83TT7_ECOLX)
Organism: Escherichia coli
Activity: IC50 = 7.22
Assay: Inhibition of Escherichia coli ATCC 25922 AmpC
Drug: aztreonam
Target: Efflux transporter; SugE (Transporter)
Gene: sugE
UniProt: Q3S5C3 (Q3S5C3_SALNE)
Organism: Salmonella newport
Activity: IC50 = 8.22
Assay: Inhibition of Salmonella enterica serotype Newport AM17274 cephalosporinase CMY-31 by UV spectrophotometer in presence of 100 uM of cephalothin
Drug: aztreonam
Target: Beta-lactamase (Enzyme)
Gene: bla LAT-2
UniProt: Q48435 (Q48435_KLEPN)
Organism: Klebsiella pneumoniae
Activity: IC50 = 8.22
Assay: Inhibition of Klebsiella pneumoniae HP205 cephalosporinase CMY-36 by UV spectrophotometer in presence of 100 uM of cephalothin
Drug: aztreonam
Target: Beta-lactamase (Enzyme)
UniProt: B2ZTR6 (B2ZTR6_ACIBA)
Organism: Acinetobacter baumannii
Activity: Ki = 8.15
Assay: Activity of Acinetobacter baumannii ADC-33 beta-lactamase
Drug: aztreonam
Target: Beta-lactamase (Enzyme)
Gene: ampC
UniProt: D6NSM8 (D6NSM8_ACIBA)
Organism: Acinetobacter baumannii
Activity: Ki = 5.52
Assay: Activity of Acinetobacter baumannii ADC-11 beta-lactamase
Drug: bacampicillin
Target: Bacterial penicillin-binding protein (Enzyme)
Gene: mrcA|mrcB|dacC|mrdA|ftsI|dacA|dacB
UniProt: P02918|P02919|P08506|P0AD65|P0AD68|P0AEB2|P24228 (PBPA_ECOLI|PBPB_ECOLI|DACC_ECOLI|PBP2_ECOLI|FTSI_ECOLI|DACA_ECOLI|DACB_ECOLI)
Organism: Escherichia coli (strain K12)
Action type: INHIBITOR
Assay: Mechanism of Action; CHEMBL2354204; PROTEIN FAMILY
Drug: bacitracin
Target: Epidermal growth factor receptor (Kinase)
Gene: EGFR
UniProt: P00533 (EGFR_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.269
Assay: DRUGMATRIX: Protein Tyrosine Kinase, EGF Receptor enzyme inhibition (substrate: Poly(Glu:Tyr))
Drug: bacitracin
Target: Tyrosine-protein kinase Lck (Kinase)
Gene: LCK
UniProt: P06239 (LCK_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.716
Assay: DRUGMATRIX: Protein Tyrosine Kinase, LCK enzyme inhibition (substrate: Poly(Glu:Tyr))
Drug: bacitracin
Target: 5-hydroxytryptamine receptor 1B (GPCR)
Gene: Htr1b
UniProt: P28564 (5HT1B_RAT)
Organism: Rattus norvegicus
Activity: Ki = 5.868
Assay: DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)
Drug: bacitracin
Target: Undecaprenyl-diphosphatase (Unclassified)
Gene: uppP
UniProt: P60932 (UPPP_ECOLI)
Organism: Escherichia coli
Activity: IC50 = 5.25
Assay: Inhibition of Escherichia coli UPPP expressed in Escherichia coli C41(DE3) using FPP as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins by malachite green assay
Drug: baclofen
Target: GABA B receptor (GPCR)
Gene: Gabbr2|Gabbr1
UniProt: O88871|Q9Z0U4 (GABR2_RAT|GABR1_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 7.52
Assay: In vitro displacement of [3H]GABA from Gamma-aminobutyric acid type B receptor sites in rat brain membranes
Drug: baclofen
Target: GABA-B receptor (GPCR)
Gene: GABBR2|GABBR1
UniProt: O75899|Q9UBS5 (GABR2_HUMAN|GABR1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7.46
Action type: AGONIST
Assay: Inhibition of [3H]-baclofen binding to Gamma-aminobutyric acid type B receptor of cat cerebellum
Drug: baclofen
Target: Adenosine receptor A3 (GPCR)
Gene: ADORA3
UniProt: P0DMS8 (AA3R_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7.3
Assay: Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug: baclofen
Target: GABA-A receptor; anion channel (Ion channel)
Gene: Gabrp|Gabrb1|Gabrd|Gabrg2|Gabra5|Gabra3|Gabrg1|Gabra2|Gabra4|Gabrg3|Gabra6|Gabra1|Gabrb3|Gabrb2|Gabrq|Gabre
UniProt: O09028|P15431|P18506|P18508|P19969|P20236|P23574|P23576|P28471|P28473|P30191|P62813|P63079|P63138|Q91ZM7|Q9ES14 (GBRP_RAT|GBRB1_RAT|GBRD_RAT|GBRG2_RAT|GBRA5_RAT|GBRA3_RAT|GBRG1_RAT|GBRA2_RAT|GBRA4_RAT|GBRG3_RAT|GBRA6_RAT|GBRA1_RAT|GBRB3_RAT|GBRB2_RAT|Q91ZM7_RAT|GBRE_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 7.52
Assay: Displacement of [3H]GABA from Gamma-aminobutyric acid A (GABA-A) receptor in rat brain membranes
Drug: balsalazide
Target: Prostaglandin G/H synthase 2 (Enzyme)
Gene: PTGS2
UniProt: P35354 (PGH2_HUMAN)
Organism: Homo sapiens
Action type: INHIBITOR
Drug: balsalazide
Target: Prostaglandin G/H synthase 1 (Enzyme)
Gene: PTGS1
UniProt: P23219 (PGH1_HUMAN)
Organism: Homo sapiens
Action type: INHIBITOR
Drug: balsalazide
Target: Arachidonate 5-lipoxygenase (Enzyme)
Gene: ALOX5
UniProt: P09917 (LOX5_HUMAN)
Organism: Homo sapiens
Action type: INHIBITOR
Assay: Mechanism of Action; CHEMBL215; SINGLE PROTEIN
Drug: balsalazide
Target: Peroxisome proliferator-activated receptor gamma (Nuclear hormone receptor)
Gene: PPARG
UniProt: P37231 (PPARG_HUMAN)
Organism: Homo sapiens
Action type: AGONIST
Assay: Mechanism of Action; CHEMBL235; SINGLE PROTEIN
Drug: bambuterol
Target: Beta-2 adrenergic receptor (GPCR)
Gene: ADRB2
UniProt: P07550 (ADRB2_HUMAN)
Organism: Homo sapiens
Drug: bambuterol
Target: Cytochrome P450 2D6 (Enzyme)
Gene: CYP2D6
UniProt: P10635 (CP2D6_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.699
Assay: DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)
Drug: bambuterol
Target: Acetylcholinesterase (Enzyme)
Gene: ACHE
UniProt: P22303 (ACES_HUMAN)
Organism: Homo sapiens
Activity: Ki = 3.25
Drug: bambuterol
Target: Cholinesterase (Enzyme)
Gene: BCHE
UniProt: P06276 (CHLE_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 8.5
Action type: INHIBITOR
Drug: bambuterol
Target: Cholinesterase (Enzyme)
Gene: BCHE
UniProt: P81908 (CHLE_HORSE)
Organism: Equus caballus
Activity: IC50 = 6.92
Assay: Inhibition of equine serum BuChE using S-butyrylthiocholine iodide as substrate preincubated for 60 mins followed by substrate addition measured after 5 mins by Ellman's method
Drug: bamipine
Target: Histamine H1 receptor (GPCR)
Gene: HRH1
UniProt: P35367 (HRH1_HUMAN)
Organism: Homo sapiens
Action type: ANTAGONIST
Assay: Mechanism of Action
Drug: barnidipine
Target: Voltage-gated L-type calcium channel (Ion channel)
Gene: CACNA1D|CACNA1C
UniProt: Q01668|Q13936 (CAC1D_HUMAN|CAC1C_HUMAN)
Organism: Homo sapiens
Action type: BLOCKER
Assay: Mechanism of Action
Drug: beclometasone dipropionate
Target: Glucocorticoid receptor (Nuclear hormone receptor)
Gene: NR3C1
UniProt: P04150 (GCR_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.427
Action type: AGONIST
Assay: DRUGMATRIX: Glucocorticoid radioligand binding (ligand: [3H] Dexamethasone)
Drug: beclometasone dipropionate
Target: Interleukin-5 (Cytokine)
Gene: IL5
UniProt: P05113 (IL5_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.57
Assay: Inhibition of interleukin-5
Drug: beclometasone dipropionate
Target: Mineralocorticoid receptor (Nuclear hormone receptor)
Gene: NR3C2
UniProt: P08235 (MCR_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 8.32
Assay: Induction of nuclear translocation of human recombinant ProLabel-tagged mineralocorticoid receptor expressed in CHO-K1 cells after 3 hrs by luminescence method
Drug: beclometasone dipropionate
Target: Progesterone receptor (Nuclear hormone receptor)
Gene: PGR
UniProt: P06401 (PRGR_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7.55
Assay: Displacement of fluormone labelled PL Red from human recombinant progesterone receptor after 1 to 6 hrs ligand by fluorescence polarization assay
Drug: beclometasone dipropionate
Target: Matrix metalloproteinase-9 (Enzyme)
Gene: MMP9
UniProt: P14780 (MMP9_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.7
Assay: DRUGMATRIX: Protease, Matrix Metalloprotease-9 (MMP-9) enzyme inhibition (substrate: Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2)
Drug: beclometasone dipropionate
Target: Androgen receptor (Transcription factor)
Gene: Ar
UniProt: P15207 (ANDR_RAT)
Organism: Rattus norvegicus
Activity: Ki = 5.96
Assay: DRUGMATRIX: Androgen (Testosterone) AR radioligand binding (ligand: [3H] Mibolerone)
Drug: beclometasone dipropionate
Target: Progesterone receptor (Transcription factor)
Gene: PGR
UniProt: Q690N0 (Q690N0_BOVIN)
Organism: Bos taurus
Activity: Ki = 7.57
Assay: DRUGMATRIX: Progesterone radioligand binding (ligand: [3H] R-5020)
Drug: beclometasone dipropionate
Target: Glucocorticoid receptor (Transcription factor)
Gene: Nr3c1
UniProt: P06536 (GCR_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 8.54
Assay: Steroid binding against the rat thymus glucocorticoid receptor
Drug: beclometasone dipropionate
Target: Probable G-protein coupled receptor 97 (GPCR)
Gene: ADGRG3
UniProt: Q86Y34 (AGRG3_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 8.5
Action type: AGONIST
Drug: beclometasone dipropionate
Target: Interleukin-5 (Unclassified)
Gene: Il5
UniProt: P04401 (IL5_MOUSE)
Organism: Mus musculus
Activity: IC50 = 4.58
Assay: Inhibition of IL5-mediated proliferation of mouse Y16 cells by WST1 assay
Drug: belotecan
Target: DNA topoisomerase 1 (Enzyme)
Gene: TOP1
UniProt: P11387 (TOP1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.561
Action type: INHIBITOR
Drug: benazepril
Target: Angiotensin-converting enzyme (Enzyme)
Gene: ACE
UniProt: P12821 (ACE_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.51
Action type: INHIBITOR
Drug: benazepril
Target: Angiotensin-converting enzyme (Enzyme)
Gene: ACE
UniProt: P12822 (ACE_RABIT)
Organism: Oryctolagus cuniculus
Activity: IC50 = 8.7
Assay: Tested for 50% inhibition of Angiotensin converting enzyme(ACE) obtained from rabbit lung (in vitro)
Drug: benazepril
Target: Angiotensin-converting enzyme (Enzyme)
Gene: Ace
UniProt: P47820 (ACE_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 8.77
Assay: In vitro inhibitory activity against Angiotensin I converting enzyme
Drug: bendamustine
Target: Histone deacetylase 2 (Enzyme)
Gene: HDAC2
UniProt: Q92769 (HDAC2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 8.05
Drug: bendamustine
Target: Histone deacetylase 1 (Enzyme)
Gene: HDAC1
UniProt: Q13547 (HDAC1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7.77
Drug: bendamustine
Target: Histone deacetylase 3 (Enzyme)
Gene: HDAC3
UniProt: O15379 (HDAC3_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7.6
Drug: bendamustine
Target: Histone deacetylase 6 (Enzyme)
Gene: HDAC6
UniProt: Q9UBN7 (HDAC6_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 8.22
Drug: bendamustine
Target: Histone deacetylase 8 (Enzyme)
Gene: HDAC8
UniProt: Q9BY41 (HDAC8_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.97
Drug: bendamustine
Target: Histone deacetylase 10 (Enzyme)
Gene: HDAC10
UniProt: Q969S8 (HDA10_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7.14
Drug: bendroflumethiazide
Target: Carbonic anhydrase 2 (Enzyme)
Gene: CA2
UniProt: P00918 (CAH2_HUMAN)
Organism: Homo sapiens
Drug: bendroflumethiazide
Target: Solute carrier family 12 member 3 (Transporter)
Gene: SLC12A3
UniProt: P55017 (S12A3_HUMAN)
Organism: Homo sapiens
Activity: A2 = 8.3
Action type: INHIBITOR
Drug: bendroflumethiazide
Target: Carbonic anhydrase 1 (Enzyme)
Gene: CA1
UniProt: P00915 (CAH1_HUMAN)
Organism: Homo sapiens
Drug: bendroflumethiazide
Target: Carbonic anhydrase 4 (Enzyme)
Gene: CA4
UniProt: P22748 (CAH4_HUMAN)
Organism: Homo sapiens
Drug: bendroflumethiazide
Target: Calcium-activated potassium channel subunit alpha-1 (Ion channel)
Gene: KCNMA1
UniProt: Q12791 (KCMA1_HUMAN)
Organism: Homo sapiens
Drug: benoxaprofen
Target: Arachidonate 5-lipoxygenase (Enzyme)
Gene: ALOX5
UniProt: P09917 (LOX5_HUMAN)
Organism: Homo sapiens
Action type: INHIBITOR
Assay: Mechanism of Action
Drug: benoxaprofen
Target: Bile salt export pump (Transporter)
Gene: Abcb11
UniProt: O70127 (ABCBB_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 4
Drug: benperidol
Target: D(2) dopamine receptor (GPCR)
Gene: DRD2
UniProt: P14416 (DRD2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 10.57
Drug: benperidol
Target: Sigma non-opioid intracellular receptor 1 (Membrane receptor)
Gene: SIGMAR1
UniProt: Q99720 (SGMR1_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 5.94
Drug: benperidol
Target: Potassium voltage-gated channel subfamily H member 2 (Ion channel)
Gene: KCNH2
UniProt: Q12809 (KCNH2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 8.47
Drug: benperidol
Target: 5-hydroxytryptamine receptor 2A (GPCR)
Gene: HTR2A
UniProt: P28223 (5HT2A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 9
Drug: benperidol
Target: D(3) dopamine receptor (GPCR)
Gene: DRD3
UniProt: P35462 (DRD3_HUMAN)
Organism: Homo sapiens
Activity: Ki = 10.18
Drug: benperidol
Target: D(4) dopamine receptor (GPCR)
Gene: DRD4
UniProt: P21917 (DRD4_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.7
Drug: diphenidol
Target: D(2) dopamine receptor (GPCR)
Gene: DRD2
UniProt: P14416 (DRD2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.96
Assay: DRUGMATRIX: Dopamine D2L radioligand binding (ligand: [3H] Spiperone)
Drug: diphenidol
Target: Sigma non-opioid intracellular receptor 1 (Membrane receptor)
Gene: SIGMAR1
UniProt: Q99720 (SGMR1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.967
Assay: DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol)
Drug: diphenidol
Target: 5-hydroxytryptamine receptor 2A (GPCR)
Gene: HTR2A
UniProt: P28223 (5HT2A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.131
Assay: DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin)
Drug: diphenidol
Target: D(3) dopamine receptor (GPCR)
Gene: DRD3
UniProt: P35462 (DRD3_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.105
Assay: DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone)
Drug: diphenidol
Target: Muscarinic acetylcholine receptor M1 (GPCR)
Gene: CHRM1
UniProt: P11229 (ACM1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.108
Action type: ANTAGONIST
Assay: DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine)
Drug: diphenidol
Target: Muscarinic acetylcholine receptor M2 (GPCR)
Gene: CHRM2
UniProt: P08172 (ACM2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.562
Assay: DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)
Drug: diphenidol
Target: Muscarinic acetylcholine receptor M3 (GPCR)
Gene: CHRM3
UniProt: P20309 (ACM3_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.284
Assay: DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)
Drug: diphenidol
Target: Muscarinic acetylcholine receptor M4 (GPCR)
Gene: CHRM4
UniProt: P08173 (ACM4_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.42
Assay: DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine)
Drug: diphenidol
Target: Muscarinic acetylcholine receptor M5 (GPCR)
Gene: CHRM5
UniProt: P08912 (ACM5_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.068
Assay: DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
Drug: diphenidol
Target: Cytochrome P450 2D6 (Enzyme)
Gene: CYP2D6
UniProt: P10635 (CP2D6_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.486
Assay: DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)
Drug: diphenidol
Target: Alpha-1B adrenergic receptor (GPCR)
Gene: Adra1b
UniProt: P15823 (ADA1B_RAT)
Organism: Rattus norvegicus
Activity: Ki = 5.579
Assay: DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
Drug: diphenidol
Target: Sodium channel alpha subunits; brain (Types I, II, III) (Ion channel)
Gene: SCN1A|SCN2A|SCN3A
UniProt: P35498|Q99250|Q9NY46 (SCN1A_HUMAN|SCN2A_HUMAN|SCN3A_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.47
Assay: Inhibition of binding of Batrachotoxinin [3H]BTX-B to high affinity sites on voltage dependent sodium channels in a vesicular preparation from guinea pig cerebral cortex
Drug: benserazide
Target: Aromatic-L-amino-acid decarboxylase (Enzyme)
Gene: DDC
UniProt: P20711 (DDC_HUMAN)
Organism: Homo sapiens
Drug: benserazide
Target: Estrogen receptor beta (Nuclear hormone receptor)
Gene: ESR2
UniProt: Q92731 (ESR2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.52
Assay: PUBCHEM_BIOASSAY: Estrogen Receptor-beta Coactivator Binding Inhibitors ELISA Secondary Assay. (Class of assay: confirmatory) [Related pubchem assays: 633 (Primary screen preceding this ELISA dose response confirmation assay.), 733 (Primary dose response assay preceding this ELISA dose response confirmation assay.)]
Drug: benserazide
Target: Zinc finger protein mex-5 (Cytosolic other)
Gene: mex-5
UniProt: Q9XUB2 (MEX5_CAEEL)
Organism: Caenorhabditis elegans
Activity: EC50 = 6.95
Assay: Active