AIM-Harvard/TrialPanorama-filtered huggingface dataset:
Drug: nefazodone
Target: 5-hydroxytryptamine receptor 2A (GPCR)
Gene: HTR2A
UniProt: P28223 (5HT2A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8
Action type: ANTAGONIST
Drug: nefazodone
Target: 5-hydroxytryptamine receptor 2C (GPCR)
Gene: HTR2C
UniProt: P28335 (5HT2C_HUMAN)
Organism: Homo sapiens
Activity: Ki  7.143
Drug: nefazodone
Target: Alpha-1A adrenergic receptor (GPCR)
Gene: ADRA1A
UniProt: P35348 (ADA1A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.789
Drug: nefazodone
Target: Alpha-2B adrenergic receptor (GPCR)
Gene: ADRA2B
UniProt: P18089 (ADA2B_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.635
Drug: nefazodone
Target: Histamine H1 receptor (GPCR)
Gene: HRH1
UniProt: P35367 (HRH1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.432
Drug: nefazodone
Target: Sodium-dependent dopamine transporter (Transporter)
Gene: SLC6A3
UniProt: Q01959 (SC6A3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.444
Drug: nefazodone
Target: Acetylcholinesterase (Enzyme)
Gene: ACHE
UniProt: P22303 (ACES_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.98
Assay: Inhibition of AChE (unknown origin)
Drug: nefazodone
Target: Bile salt export pump (Transporter)
Gene: ABCB11
UniProt: O95342 (ABCBB_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.38
Drug: nefazodone
Target: 5-hydroxytryptamine receptor 1A (GPCR)
Gene: Htr1a
UniProt: P19327 (5HT1A_RAT)
Organism: Rattus norvegicus
Activity: Ki = 7.28
Assay: Binding affinity to rat 5HT1A receptor
Drug: nefazodone
Target: Sodium-dependent serotonin transporter (Transporter)
Gene: Slc6a4
UniProt: P31652 (SC6A4_RAT)
Organism: Rattus norvegicus
Activity: Ki = 6.86
Assay: Inhibition of [3H]5-HT reuptake into rat frontal cortex synaptosomes
Drug: nefazodone
Target: Sodium-dependent dopamine transporter (Transporter)
Gene: Slc6a3
UniProt: P23977 (SC6A3_RAT)
Organism: Rattus norvegicus
Activity: Ki = 5.62
Assay: Inhibition of [3H]- DA reuptake into rat striatal synaptosomes
Drug: nefazodone
Target: 5-hydroxytryptamine receptor 2A (GPCR)
Gene: Htr2a
UniProt: P14842 (5HT2A_RAT)
Organism: Rattus norvegicus
Activity: Ki = 8.15
Assay: Binding affinity to rat 5HT2A receptor
Drug: nefazodone
Target: Transporter (Transporter)
Gene: Slc6a2
UniProt: Q9WTR4 (Q9WTR4_RAT)
Organism: Rattus norvegicus
Activity: Ki = 6.24
Assay: Inhibition of [3H]- NE reuptake into rat hippocampal synaptosomes
Drug: nefazodone
Target: Bile salt export pump (Transporter)
Gene: Abcb11
UniProt: O70127 (ABCBB_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 4.76
Drug: nefopam
Target: Sodium channel protein type 5 subunit alpha (Ion channel)
Gene: SCN5A
UniProt: Q14524 (SCN5A_HUMAN)
Organism: Homo sapiens
Drug: nefopam
Target: Sodium-dependent serotonin transporter (Transporter)
Gene: SLC6A4
UniProt: P31645 (SC6A4_HUMAN)
Organism: Homo sapiens
Activity: Ki  7.538
Drug: nefopam
Target: Sodium-dependent noradrenaline transporter (Transporter)
Gene: SLC6A2
UniProt: P23975 (SC6A2_HUMAN)
Organism: Homo sapiens
Activity: Ki  7.481
Drug: nefopam
Target: 5-hydroxytryptamine receptor 2A (GPCR)
Gene: HTR2A
UniProt: P28223 (5HT2A_HUMAN)
Organism: Homo sapiens
Activity: Ki  5.773
Drug: nefopam
Target: 5-hydroxytryptamine receptor 2B (GPCR)
Gene: HTR2B
UniProt: P41595 (5HT2B_HUMAN)
Organism: Homo sapiens
Activity: Ki  6.481
Drug: nefopam
Target: 5-hydroxytryptamine receptor 2C (GPCR)
Gene: HTR2C
UniProt: P28335 (5HT2C_HUMAN)
Organism: Homo sapiens
Activity: Ki  7.252
Drug: nefopam
Target: Sodium-dependent dopamine transporter (Transporter)
Gene: SLC6A3
UniProt: Q01959 (SC6A3_HUMAN)
Organism: Homo sapiens
Activity: Ki  6.275
Drug: nelfinavir
Target: Mu-type opioid receptor (GPCR)
Gene: OPRM1
UniProt: P35372 (OPRM_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.232
Assay: DRUGMATRIX: Opiate mu (OP3, MOP) radioligand binding (ligand: [3H] Diprenorphine)
Drug: nelfinavir
Target: D(1A) dopamine receptor (GPCR)
Gene: DRD1
UniProt: P21728 (DRD1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.189
Assay: DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)
Drug: nelfinavir
Target: Cytochrome P450 3A4 (Enzyme)
Gene: CYP3A4
UniProt: P08684 (CP3A4_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.699
Assay: DRUGMATRIX: CYP450, 3A4 enzyme inhibition (substrate: 7-Benzyloxy-4-(trifluoromethyl)-coumarin)
Drug: nelfinavir
Target: Multidrug resistance protein 1 (Transporter)
Gene: ABCB1
UniProt: P08183 (MDR1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.7
Assay: Inhibition of human MDR1-dependent accumulation of calcein-AM expressed in MDCK2 cells
Drug: nelfinavir
Target: Sodium-dependent noradrenaline transporter (Transporter)
Gene: SLC6A2
UniProt: P23975 (SC6A2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.057
Assay: DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55)
Drug: nelfinavir
Target: Muscarinic acetylcholine receptor M5 (GPCR)
Gene: CHRM5
UniProt: P08912 (ACM5_HUMAN)
Organism: Homo sapiens
Activity: Ki = 4.209
Assay: DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
Drug: nelfinavir
Target: Beta-3 adrenergic receptor (GPCR)
Gene: ADRB3
UniProt: P13945 (ADRB3_HUMAN)
Organism: Homo sapiens
Activity: Ki = 4.592
Assay: DRUGMATRIX: Adrenergic beta3 radioligand binding (ligand: [125I] Cyanopindolol)
Drug: nelfinavir
Target: Sodium-dependent dopamine transporter (Transporter)
Gene: SLC6A3
UniProt: Q01959 (SC6A3_HUMAN)
Organism: Homo sapiens
Activity: Ki = 4.909
Assay: DRUGMATRIX: Dopamine Transporter radioligand binding (ligand: [125I] RTI-55)
Drug: nelfinavir
Target: Adenosine receptor A3 (GPCR)
Gene: ADORA3
UniProt: P0DMS8 (AA3R_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.078
Assay: DRUGMATRIX: Adenosine A3 radioligand binding (ligand: AB-MECA)
Drug: nelfinavir
Target: Kappa-type opioid receptor (GPCR)
Gene: OPRK1
UniProt: P41145 (OPRK_HUMAN)
Organism: Homo sapiens
Activity: Ki = 4.842
Assay: DRUGMATRIX: Opiate kappa (OP2, KOP) radioligand binding (ligand: [3H] Diprenorphine)
Drug: nelfinavir
Target: Delta-type opioid receptor (GPCR)
Gene: OPRD1
UniProt: P41143 (OPRD_HUMAN)
Organism: Homo sapiens
Activity: Ki = 4.632
Assay: DRUGMATRIX: Opiate delta1 (OP1, DOP) radioligand binding (ligand: [3H] Naltrindole)
Drug: nelfinavir
Target: Epidermal growth factor receptor (Kinase)
Gene: EGFR
UniProt: P00533 (EGFR_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.255
Assay: DRUGMATRIX: Protein Tyrosine Kinase, EGF Receptor enzyme inhibition (substrate: Poly(Glu:Tyr))
Drug: nelfinavir
Target: Gag-Pol polyprotein (Polyprotein)
Gene: gag-pol
UniProt: P03367 (POL_HV1BR)
Organism: Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI)
Drug: nelfinavir
Target: Tyrosine-protein kinase Lck (Kinase)
Gene: LCK
UniProt: P06239 (LCK_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.101
Assay: DRUGMATRIX: Protein Tyrosine Kinase, LCK enzyme inhibition (substrate: Poly(Glu:Tyr))
Drug: nelfinavir
Target: Tyrosine-protein kinase Fyn (Kinase)
Gene: FYN
UniProt: P06241 (FYN_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.098
Assay: DRUGMATRIX: Protein Tyrosine Kinase, Fyn enzyme inhibition (substrate: Poly(Glu:Tyr))
Drug: nelfinavir
Target: Thromboxane-A synthase (Enzyme)
Gene: TBXAS1
UniProt: P24557 (THAS_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.676
Assay: DRUGMATRIX: Thromboxane Synthetase enzyme inhibition (substrate: PGH2)
Drug: nelfinavir
Target: Mitogen-activated protein kinase 3 (Kinase)
Gene: MAPK3
UniProt: P27361 (MK03_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.648
Assay: DRUGMATRIX: Protein Serine/Threonine Kinase, ERK1 enzyme inhibition (substrate: Myelin Basic Protein)
Drug: nelfinavir
Target: Mitogen-activated protein kinase 14 (Kinase)
Gene: MAPK14
UniProt: Q16539 (MK14_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.739
Assay: DRUGMATRIX: Protein Serine/Threonine Kinase, p38alpha enzyme inhibition (substrate: Myelin Basic Protein)
Drug: nelfinavir
Target: Substance-K receptor (GPCR)
Gene: TACR2
UniProt: P21452 (NK2R_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.009
Assay: DRUGMATRIX: Tachykinin NK2  radioligand binding (ligand: [3H] SR-48968)
Drug: nelfinavir
Target: Androgen receptor (Transcription factor)
Gene: Ar
UniProt: P15207 (ANDR_RAT)
Organism: Rattus norvegicus
Activity: Ki = 4.615
Assay: DRUGMATRIX: Androgen (Testosterone) AR radioligand binding (ligand: [3H] Mibolerone)
Drug: nelfinavir
Target: Arachidonate 15-lipoxygenase (Enzyme)
Gene: ALOX15
UniProt: P12530 (LOX15_RABIT)
Organism: Oryctolagus cuniculus
Activity: IC50 = 4.86
Assay: DRUGMATRIX: Lipoxygenase 15-LO enzyme inhibition (substrate: Linoleic acid)
Drug: nelfinavir
Target: Progesterone receptor (Transcription factor)
Gene: PGR
UniProt: Q690N0 (Q690N0_BOVIN)
Organism: Bos taurus
Activity: Ki = 5.236
Assay: DRUGMATRIX: Progesterone radioligand binding (ligand: [3H] R-5020)
Drug: nelfinavir
Target: Pol polyprotein (Enzyme)
Gene: pol
UniProt: Q72874 (Q72874_9HIV1)
Organism: Human immunodeficiency virus 1
Activity: Ki = 11
Action type: INHIBITOR
Assay: Inhibition of HIV protease
Drug: nelfinavir
Target: Protease (Enzyme)
Gene: protease
UniProt: Q9YQ12 (Q9YQ12_9HIV1)
Organism: Human immunodeficiency virus 1
Activity: Ki = 10.15
Assay: Inhibition of wild-type HIV1 BH10 protease expressed in Escherichia coli by spectrophotometric assay
Drug: nelfinavir
Target: Protease (Unclassified)
Gene: HIV-1 protease
UniProt: O90781 (O90781_9PLVG)
Organism: Human immunodeficiency virus
Activity: Ki = 8.49
Assay: Inhibition of HIV1 recombinant protease A71V/V82T/I84V mutant expressed in Escherichia coli by spectrophotometric assay
Drug: nelfinavir
Target: Protease (Unclassified)
Gene: HIV-1 protease
UniProt: Q9YQ30 (Q9YQ30_9PLVG)
Organism: Human immunodeficiency virus
Activity: Ki = 8.68
Assay: Inhibition of HIV1 recombinant protease L10I/I15V/E35D/N37S/R41K/I62V/L63P/A71V/G73S/L90M mutant expressed in Escherichia coli by spectrophotometric assay
Drug: nemonapride
Target: D(3) dopamine receptor (GPCR)
Gene: DRD3
UniProt: P35462 (DRD3_HUMAN)
Organism: Homo sapiens
Activity: Ki = 9.3
Action type: ANTAGONIST
Drug: nemonapride
Target: D(4) dopamine receptor (GPCR)
Gene: DRD4
UniProt: P21917 (DRD4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 9.68
Assay: Binding Affinity to Human Dopamine receptor D4 expressed in CHO cells was determined using [3H]- nemonapride as radioligand
Drug: nemonapride
Target: Alpha-1A adrenergic receptor (GPCR)
Gene: Adra1a
UniProt: P43140 (ADA1A_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 6.27
Assay: Binding affinity to the alpha-1 adrenergic receptor using a radioligand [3H]prazosin binding assay in rat brain membranes
Drug: nemonapride
Target: D(2) dopamine receptor (GPCR)
Gene: Drd2
UniProt: P61169 (DRD2_RAT)
Organism: Rattus norvegicus
Activity: Ki = 9.8
Assay: Binding affinity to rat Dopamine receptor D2 expressed in CHO cells was determined using [125 I ] iodosulpride as radioligand
Drug: nemonapride
Target: 5-hydroxytryptamine receptor 2A (GPCR)
Gene: Htr2a
UniProt: P14842 (5HT2A_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 7.31
Assay: Binding affinity to serotonin 5-hydroxytryptamine 2A receptors using a radioligand [3H]ketanserin binding assay in rat cortical membranes
Drug: nemonapride
Target: D(3) dopamine receptor (GPCR)
Gene: Drd3
UniProt: P19020 (DRD3_RAT)
Organism: Rattus norvegicus
Activity: Ki = 9.8
Assay: Binding affinity to rat Dopamine receptor D3 expressed in CHO cells was determined using [125 I] iodosulpride as radioligand
Drug: framycetin
Target: Transient receptor potential cation channel subfamily V member 1 (Ion channel)
Gene: TRPV1
UniProt: Q8NER1 (TRPV1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.4
Assay: Inhibition of TRPV1-mediated membrane currents in human DRG neurons
Drug: framycetin
Target: 30S ribosomal protein S12 (Cytosolic other)
Gene: rpsL
UniProt: P0A7S3 (RS12_ECOLI)
Organism: Escherichia coli (strain K12)
Drug: framycetin
Target: Phenylalanine--tRNA ligase alpha subunit (Enzyme)
Gene: pheS
UniProt: P08312 (SYFA_ECOLI)
Organism: Escherichia coli (strain K12)
Drug: framycetin
Target: Phenylalanine--tRNA ligase beta subunit (Enzyme)
Gene: pheT
UniProt: P07395 (SYFB_ECOLI)
Organism: Escherichia coli (strain K12)
Drug: framycetin
Target: Lethal factor (Enzyme)
Gene: lef
UniProt: P15917 (LEF_BACAN)
Organism: Bacillus anthracis
Activity: Ki = 6.3
Assay: Inhibition of anthrax lethal factor metalloprotease
Drug: framycetin
Target: Lecithin retinol acyltransferase (Enzyme)
Gene: LRAT
UniProt: O95237 (LRAT_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.83
Assay: Compound tested in vitro for inhibition of translation using highly active Escherichia coli S30 and a plasmid containing a gene expressing truncated lecithin retinol acyltransferase
Drug: framycetin
Target: Menin (Unclassified)
Gene: MEN1
UniProt: O00255 (MEN1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 4.81
Assay: Binding affinity to menin (unknown origin) by isothermal titration calorimetry analysis
Drug: framycetin
Target: Extracellular calcium-sensing receptor (GPCR)
Gene: Casr
UniProt: P48442 (CASR_RAT)
Organism: Rattus norvegicus
Activity: Kd = 4
Action type: AGONIST
Drug: neostigmine
Target: Acetylcholinesterase (Enzyme)
Gene: ACHE
UniProt: P22303 (ACES_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7.59
Action type: INHIBITOR
Drug: neostigmine
Target: Cholinesterase (Enzyme)
Gene: BCHE
UniProt: P06276 (CHLE_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7.22
Assay: Inhibition of human plasma BChE pretreated for 30 mins by Ellman technique
Drug: neostigmine
Target: Acetylcholinesterase (Enzyme)
Gene: ache
UniProt: P04058 (ACES_TORCA)
Organism: Torpedo californica
Activity: IC50 = 8.34
Assay: Inhibition of Torpedo californica eel AChE using acetylthiocholine/DTNB as substrate preincubated for 10 mins followed by substrate addition measured every 30 secs for 30 mins by Ellmans method
Drug: neostigmine
Target: Acetylcholinesterase (Enzyme)
Gene: Ache
UniProt: P37136 (ACES_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 7.46
Assay: Inhibition of Wistar rat brain AChE by Ellman colorimetric assay
Drug: neostigmine
Target: Acetylcholinesterase (Enzyme)
Gene: ache
UniProt: O42275 (ACES_ELEEL)
Organism: Electrophorus electricus
Activity: Ki = 6
Assay: Tested for in vitro inhibition of acetylcholinesterase
Drug: neostigmine
Target: Cholinesterase (Enzyme)
Gene: BCHE
UniProt: P81908 (CHLE_HORSE)
Organism: Equus caballus
Activity: IC50 = 7.15
Assay: Inhibition of equine serum BChE using butyrylthiocholine iodide as substrate after 10 mins by Ellman method
Drug: nepafenac
Target: Prostaglandin G/H synthase 2 (Enzyme)
Gene: PTGS2
UniProt: P35354 (PGH2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.82
Action type: INHIBITOR
Drug: nepafenac
Target: Prostaglandin G/H synthase 1 (Enzyme)
Gene: PTGS1
UniProt: P23219 (PGH1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.6
Action type: INHIBITOR
Drug: nepafenac
Target: Cyclooxygenase (Enzyme)
Gene: PTGS1|PTGS2
UniProt: O62664|O62698 (PGH1_BOVIN|PGH2_BOVIN)
Organism: Bos taurus
Activity: IC50 = 6.7
Assay: Inhibition of PG synthetase activity obtained from bovine seminal vesicles
Drug: nepafenac
Target: Cyclooxygenase (Enzyme)
Gene: Ptgs2|Ptgs1
UniProt: P35355|Q63921 (PGH2_RAT|PGH1_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 7
Assay: Inhibitory activity against Prostaglandin G/H synthase
Drug: nepinalone
Target: Sigma non-opioid intracellular receptor 1 (Membrane receptor)
Gene: SIGMAR1
UniProt: Q99720 (SGMR1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.523
Drug: nesiritide
Target: Atrial natriuretic peptide receptor 1 (Enzyme)
Gene: NPR1
UniProt: P16066 (ANPRA_HUMAN)
Organism: Homo sapiens
Action type: AGONIST
Assay: Mechanism of Action
Drug: nevirapine
Target: Gag-Pol polyprotein (Polyprotein)
Gene: gag-pol
UniProt: P03369 (POL_HV1A2)
Organism: Human immunodeficiency virus type 1 group M subtype B (isolate ARV2/SF2)
Activity: IC50 = 7.097
Drug: nevirapine
Target: Pol polyprotein (Enzyme)
Gene: pol
UniProt: Q72874 (Q72874_9HIV1)
Organism: Human immunodeficiency virus 1
Activity: IC50 = 7
Assay: Inhibition of HIV-1 RT using rC-dG as template
Drug: nevirapine
Target: Reverse transcriptase/RNaseH (Enzyme)
Gene: pol
UniProt: Q72547 (Q72547_9HIV1)
Organism: Human immunodeficiency virus 1
Activity: Ki = 6.4
Action type: INHIBITOR
Assay: Inhibition of HIV-1 wild-type RT
Drug: nevirapine
Target: Reverse transcriptase (Enzyme)
Gene: reverse transcriptas
UniProt: Q9WKE8 (Q9WKE8_9HIV1)
Organism: Human immunodeficiency virus 1
Activity: IC50 = 6.3
Assay: Inhibition of RNA-dependent DNA polymerase activity of Human immunodeficiency virus 1 recombinant reverse transcriptase expressed in Escherichia coli using poly(rA)oligo(dT) template primer after 30 min
Drug: nevirapine
Target: Reverse transcriptase protein (Unclassified)
Gene: reverse transcriptase
UniProt: Q9WJQ2 (Q9WJQ2_9HIV1)
Organism: Human immunodeficiency virus 1
Activity: Ki = 5.4
Assay: Inhibition of HIV1 recombinant reverse transcriptase K103N mutant-DNA binary complex expressed in Escherichia coli BL21
Drug: nicotinamide
Target: Hydroxycarboxylic acid receptor 2 (GPCR)
Gene: HCAR2
UniProt: Q8TDS4 (HCAR2_HUMAN)
Organism: Homo sapiens
Drug: nicotinamide
Target: Hydroxycarboxylic acid receptor 3 (GPCR)
Gene: HCAR3
UniProt: P49019 (HCAR3_HUMAN)
Organism: Homo sapiens
Drug: nicotinamide
Target: Nicotinamide N-methyltransferase (Enzyme)
Gene: NNMT
UniProt: P40261 (NNMT_HUMAN)
Organism: Homo sapiens
Drug: nicotinamide
Target: Nicotinate-nucleotide pyrophosphorylase [carboxylating] (Enzyme)
Gene: QPRT
UniProt: Q15274 (NADC_HUMAN)
Organism: Homo sapiens
Drug: nicotinamide
Target: NAD-dependent protein deacetylase sirtuin-1 (Enzyme)
Gene: SIRT1
UniProt: Q96EB6 (SIR1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.3
Assay: Inhibition of recombinant SIRT1 using ZMAL substrate after 4 hrs by homogeneous fluorescence assay
Drug: nicotinamide
Target: NAD-dependent protein deacetylase sirtuin-2 (Enzyme)
Gene: SIRT2
UniProt: Q8IXJ6 (SIR2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.92
Assay: Inhibition of recombinant SIRT2 using ZMAL substrate after 4 hrs by homogeneous fluorescence assay
Drug: nicotinamide
Target: Fatty-acid amide hydrolase 1 (Enzyme)
Gene: Faah
UniProt: P97612 (FAAH1_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 5.48
Assay: Inhibition of Wistar rat brain FAAH
Drug: nicotinamide
Target: NAD-dependent deacetylase HST2 (Enzyme)
Gene: HST2
UniProt: P53686 (HST2_YEAST)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Activity: IC50 = 4.04
Assay: Inhibition of yeast Hst2 by fluorimetric assay
Drug: nicotinamide
Target: NAD-dependent deacetylase sirtuin 3 (Enzyme)
Gene: SIRT3
UniProt: Q9NTG7 (SIR3_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.85
Assay: Inhibition of human recombinant SIRT3 after 60 mins by fluorimetric analysis
Drug: nicotinamide
Target: NAD-dependent protein deacylase sirtuin-5, mitochondrial (Enzyme)
Gene: SIRT5
UniProt: Q9NXA8 (SIR5_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.33
Assay: Inhibition of SIRT5 using ZK(suc)A substrate after 1 hr by homogeneous fluorescence assay
Drug: nicotinamide
Target: Putative silent information regulator 2 (Unclassified)
Gene: SIR2RP1
UniProt: Q8I6E4 (Q8I6E4_LEIIN)
Organism: Leishmania infantum
Activity: IC50 = 4.4
Assay: Inhibition of Leishmania infantum SIR2RP1
Drug: nicotinamide
Target: Sterile alpha and TIR motif-containing protein 1 (Unclassified)
Gene: SARM1
UniProt: Q6SZW1 (SARM1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.36
Assay: Inhibition of StrepTag-tagged human SARM1 TIR (561 to 724 residues) expressed in HEK293T cells assessed as reduction in NADase activity in presence of NAD+ incubated for 60 mins by HPLC analysis
Drug: nicardipine
Target: Cytochrome P450 3A4 (Enzyme)
Gene: CYP3A4
UniProt: P08684 (CP3A4_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.377
Drug: nicardipine
Target: Multidrug resistance protein 1 (Transporter)
Gene: ABCB1
UniProt: P08183 (MDR1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.32
Assay: Inhibition of P-glycoprotein expressed in A2780/ADR cells by calcein AM assay
Drug: nicardipine
Target: Adenosine receptor A3 (GPCR)
Gene: ADORA3
UniProt: P0DMS8 (AA3R_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.49
Assay: Displacement of [125]AB-MECA binding to human Adenosine A3 receptor expressed in HEK cells
Drug: nicardipine
Target: Nuclear receptor subfamily 1 group I member 2 (Nuclear hormone receptor)
Gene: NR1I2
UniProt: O75469 (NR1I2_HUMAN)
Organism: Homo sapiens
Drug: nicardipine
Target: ATP-binding cassette sub-family G member 2 (Transporter)
Gene: ABCG2
UniProt: Q9UNQ0 (ABCG2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.78
Assay: Inhibition of ABCG2 in human mitoxantrone-resistant MCF7 cells by Hoechst 33342 assay
Drug: nicardipine
Target: Beta-lactamase (Enzyme)
Gene: ampC
UniProt: P00811 (AMPC_ECOLI)
Organism: Escherichia coli (strain K12)
Activity: IC50 = 4.7
Assay: Compound was tested for the inhibition of beta-lactamase
Drug: nicardipine
Target: Cytochrome P450 2C9 (Enzyme)
Gene: CYP2C9
UniProt: P11712 (CP2C9_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.553
Drug: nicardipine
Target: Voltage-dependent T-type calcium channel subunit alpha-1H (Ion channel)
Gene: CACNA1H
UniProt: O95180 (CAC1H_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.553
Drug: nicardipine
Target: Adenosine receptor A1 (GPCR)
Gene: Adora1
UniProt: P25099 (AA1R_RAT)
Organism: Rattus norvegicus
Activity: Ki = 4.71
Assay: Displacement of [3H](R)-PIA binding to Adenosine A1 receptor in rat brain membranes
Drug: nicardipine
Target: Adenosine receptor A2a (GPCR)
Gene: Adora2a
UniProt: P30543 (AA2AR_RAT)
Organism: Rattus norvegicus
Activity: Ki = 4.2
Assay: Displacement of [3H]-CGS- 21680 binding to Adenosine A2A receptor in rat striatal membranes
Drug: nicardipine
Target: Adenosine receptor A3 (GPCR)
Gene: Adora3
UniProt: P28647 (AA3R_RAT)
Organism: Rattus norvegicus
Activity: Ki = 4.96
Assay: Binding affinity against rat Adenosine A3 receptor from CHO cells
Drug: nicardipine
Target: Equilibrative nucleoside transporter 1 (Transporter)
Gene: Slc29a1
UniProt: O54698 (S29A1_RAT)
Organism: Rattus norvegicus
Activity: Ki = 5.27
Assay: Ability to displace radioligand from Na+ independent Adenosine transporter in rat
Drug: nicardipine
Target: Quinolone resistance protein NorA (Transporter)
Gene: norA
UniProt: P0A0J7 (NORA_STAAU)
Organism: Staphylococcus aureus
Activity: IC50 = 4.64
Assay: Inhibition of NorA in Staphylococcus aureus SA1199B harboring GrlA A116E mutant assessed as inhibition of ethidium bromide efflux after 5 mins by fluorometric method
Drug: nicardipine
Target: Adrenergic receptor alpha-2 (GPCR)
Gene: Adra2b|Adra2c|Adra2a
UniProt: P19328|P22086|P22909 (ADA2B_RAT|ADA2C_RAT|ADA2A_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 5.85
Assay: Alpha-2-adrenolytic activity was assessed from the ability to inhibit [3H]yohimbine binding to rat cerebral cortex preparation
Drug: nicardipine
Target: Adrenergic receptor alpha-1 (GPCR)
Gene: Adra1b|Adra1d|Adra1a
UniProt: P15823|P23944|P43140 (ADA1B_RAT|ADA1D_RAT|ADA1A_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 5.44
Assay: Alpha-1-adrenolytic activity was assessed from the ability to inhibit [3H]prazosin binding to rat cerebral cortex preparation
Drug: nicardipine
Target: Voltage-gated L-type calcium channel (Ion channel)
Gene: Cacna1c|Cacna1d|Cacna1s
UniProt: P22002|P27732|Q02485 (CAC1C_RAT|CAC1D_RAT|CAC1S_RAT)
Organism: Rattus norvegicus
Activity: Ki = 9.08
Assay: Inhibition of [3H]nitrendipine binding to L-type calcium channel from rat brain cortex homogenate
Drug: nicardipine
Target: Voltage-gated L-type calcium channel (Ion channel)
Gene: CACNA1D|CACNA1C
UniProt: Q01668|Q13936 (CAC1D_HUMAN|CAC1C_HUMAN)
Organism: Homo sapiens
Action type: BLOCKER
Assay: Mechanism of Action
Drug: nicardipine
Target: Malate dehydrogenase cytoplasmic  (Enzyme)
Gene: MDH1
UniProt: P40925 (MDHC_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.3
Assay: Inhibition of malate dehydrogenase (MDH)
Drug: nicardipine
Target: Potassium voltage-gated channel subfamily A member 4 (Ion channel)
Gene: Kcna4
UniProt: P15385 (KCNA4_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 6.1
Action type: BLOCKER
Drug: niclosamide
Target: Cytochrome P450 2C9 (Enzyme)
Gene: CYP2C9
UniProt: P11712 (CP2C9_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 7.046