AIM-Harvard/TrialPanorama-filtered huggingface dataset:
Drug: dasatinib
Target: Receptor-type tyrosine-protein kinase FLT3 (Kinase)
Gene: FLT3
UniProt: P36888 (FLT3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.49
Assay: Binding constant for FLT3(K663Q) kinase domain
Drug: dasatinib
Target: Proto-oncogene tyrosine-protein kinase receptor Ret (Kinase)
Gene: RET
UniProt: P07949 (RET_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.41
Assay: Binding constant for RET(M918T) kinase domain
Drug: dasatinib
Target: Vascular endothelial growth factor receptor 1 (Kinase)
Gene: FLT1
UniProt: P17948 (VGFR1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.3
Assay: Binding constant for FLT1 kinase domain
Drug: dasatinib
Target: Vascular endothelial growth factor receptor 2 (Kinase)
Gene: KDR
UniProt: P35968 (VGFR2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.54
Assay: Binding constant for VEGFR2 kinase domain
Drug: dasatinib
Target: Macrophage colony-stimulating factor 1 receptor (Kinase)
Gene: CSF1R
UniProt: P07333 (CSF1R_HUMAN)
Organism: Homo sapiens
Activity: Kd = 9.24
Assay: Binding constant for CSF1R kinase domain
Drug: dasatinib
Target: Platelet-derived growth factor receptor alpha (Kinase)
Gene: PDGFRA
UniProt: P16234 (PGFRA_HUMAN)
Organism: Homo sapiens
Activity: Kd = 9.33
Assay: Binding constant for PDGFRA kinase domain
Drug: dasatinib
Target: Receptor tyrosine-protein kinase erbB-2 (Kinase)
Gene: ERBB2
UniProt: P04626 (ERBB2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.85
Assay: Binding constant for ERBB2 kinase domain
Drug: dasatinib
Target: Fibroblast growth factor receptor 3 (Kinase)
Gene: FGFR3
UniProt: P22607 (FGFR3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.41
Assay: Binding constant for FGFR3 kinase domain
Drug: dasatinib
Target: Tyrosine-protein kinase HCK (Kinase)
Gene: HCK
UniProt: P08631 (HCK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 9.46
Action type: INHIBITOR
Assay: Binding constant for HCK kinase domain
Drug: dasatinib
Target: Receptor tyrosine-protein kinase erbB-4 (Kinase)
Gene: ERBB4
UniProt: Q15303 (ERBB4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.26
Assay: Binding constant for ERBB4 kinase domain
Drug: dasatinib
Target: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Kinase)
Gene: PIK3CD
UniProt: O00329 (PK3CD_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.52
Assay: Inhibition of recombinant PI3Kdelta by radioactive phosphotransfer assay in presence of 10 uM ATP
Drug: dasatinib
Target: Tyrosine-protein kinase JAK2 (Kinase)
Gene: JAK2
UniProt: O60674 (JAK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6
Assay: Binding constant for JAK2(Kin.Dom.2/JH1 - catalytic) kinase domain
Drug: dasatinib
Target: Tyrosine-protein kinase SYK (Kinase)
Gene: SYK
UniProt: P43405 (KSYK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.54
Assay: Binding constant for SYK kinase domain
Drug: dasatinib
Target: Myosin light chain kinase 2, skeletal/cardiac muscle (Kinase)
Gene: MYLK2
UniProt: Q9H1R3 (MYLK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.46
Assay: Binding constant for MYLK2 kinase domain
Drug: dasatinib
Target: Tyrosine-protein kinase CSK (Kinase)
Gene: CSK
UniProt: P41240 (CSK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 9
Assay: Binding constant for full-length CSK
Drug: dasatinib
Target: Ephrin type-A receptor 8 (Kinase)
Gene: EPHA8
UniProt: P29322 (EPHA8_HUMAN)
Organism: Homo sapiens
Activity: Kd = 9.62
Assay: Binding constant for EPHA8 kinase domain
Drug: dasatinib
Target: Tyrosine-protein kinase Lyn (Kinase)
Gene: LYN
UniProt: P07948 (LYN_HUMAN)
Organism: Homo sapiens
Activity: Kd = 9.24
Action type: INHIBITOR
Assay: Binding constant for LYN kinase domain
Drug: dasatinib
Target: Cytoplasmic tyrosine-protein kinase BMX (Kinase)
Gene: BMX
UniProt: P51813 (BMX_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.85
Assay: Binding constant for full-length BMX
Drug: dasatinib
Target: Serine/threonine-protein kinase Nek2 (Kinase)
Gene: NEK2
UniProt: P51955 (NEK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.19
Assay: Binding constant for NEK2 kinase domain
Drug: dasatinib
Target: LIM domain kinase 1 (Kinase)
Gene: LIMK1
UniProt: P53667 (LIMK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.24
Assay: Binding constant for full-length LIMK1
Drug: dasatinib
Target: Fibroblast growth factor receptor 1 (Kinase)
Gene: FGFR1
UniProt: P11362 (FGFR1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.43
Assay: Binding constant for FGFR1 kinase domain
Drug: dasatinib
Target: Serine/threonine-protein kinase 10 (Kinase)
Gene: STK10
UniProt: O94804 (STK10_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.92
Assay: Binding constant for LOK kinase domain
Drug: dasatinib
Target: Abelson tyrosine-protein kinase 2 (Kinase)
Gene: ABL2
UniProt: P42684 (ABL2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 9.77
Assay: Binding constant for ABL2 kinase domain
Drug: dasatinib
Target: Mitogen-activated protein kinase 11 (Kinase)
Gene: MAPK11
UniProt: Q15759 (MK11_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.39
Assay: Binding constant for full-length p38-beta
Drug: dasatinib
Target: Ephrin type-A receptor 5 (Kinase)
Gene: EPHA5
UniProt: P54756 (EPHA5_HUMAN)
Organism: Homo sapiens
Activity: Kd = 9.62
Assay: Binding constant for EPHA5 kinase domain
Drug: dasatinib
Target: Ephrin type-A receptor 4 (Kinase)
Gene: EPHA4
UniProt: P54764 (EPHA4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.92
Assay: Binding constant for EPHA4 kinase domain
Drug: dasatinib
Target: Fibroblast growth factor receptor 2 (Kinase)
Gene: FGFR2
UniProt: P21802 (FGFR2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.85
Assay: Binding constant for FGFR2 kinase domain
Drug: dasatinib
Target: Ephrin type-A receptor 6 (Kinase)
Gene: EPHA6
UniProt: Q9UF33 (EPHA6_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.68
Assay: Binding constant for EPHA6 kinase domain
Drug: dasatinib
Target: TRAF2 and NCK-interacting protein kinase (Kinase)
Gene: TNIK
UniProt: Q9UKE5 (TNIK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.7
Assay: Binding constant for TNIK kinase domain
Drug: dasatinib
Target: Casein kinase I isoform epsilon (Kinase)
Gene: CSNK1E
UniProt: P49674 (KC1E_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.82
Assay: Binding constant for full-length CSNK1E
Drug: dasatinib
Target: Tyrosine-protein kinase Fgr (Kinase)
Gene: FGR
UniProt: P09769 (FGR_HUMAN)
Organism: Homo sapiens
Activity: Kd = 9.3
Action type: INHIBITOR
Assay: Binding constant for FGR kinase domain
Drug: dasatinib
Target: Aurora kinase A (Kinase)
Gene: AURKA
UniProt: O14965 (AURKA_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.03
Assay: Binding constant for AURKA kinase domain
Drug: dasatinib
Target: Serine/threonine-protein kinase 36 (Kinase)
Gene: STK36
UniProt: Q9NRP7 (STK36_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.68
Assay: Binding constant for STK36 kinase domain
Drug: dasatinib
Target: Ephrin type-A receptor 3 (Kinase)
Gene: EPHA3
UniProt: P29320 (EPHA3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 10.03
Assay: Binding constant for EPHA3 kinase domain
Drug: dasatinib
Target: Mitogen-activated protein kinase 14 (Kinase)
Gene: MAPK14
UniProt: Q16539 (MK14_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.57
Assay: Binding constant for full-length p38-alpha
Drug: dasatinib
Target: Tyrosine-protein kinase FRK (Kinase)
Gene: FRK
UniProt: P42685 (FRK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 9.51
Action type: INHIBITOR
Assay: Binding constant for FRK kinase domain
Drug: dasatinib
Target: Mitogen-activated protein kinase kinase kinase kinase 5 (Kinase)
Gene: MAP4K5
UniProt: Q9Y4K4 (M4K5_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.35
Assay: Binding constant for MAP4K5 kinase domain
Drug: dasatinib
Target: Mitogen-activated protein kinase kinase kinase 4 (Kinase)
Gene: MAP3K4
UniProt: Q9Y6R4 (M3K4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.51
Assay: Binding constant for MAP3K4 kinase domain
Drug: dasatinib
Target: Cyclin-G-associated kinase (Kinase)
Gene: GAK
UniProt: O14976 (GAK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.59
Assay: Binding constant for GAK kinase domain
Drug: dasatinib
Target: Receptor-interacting serine/threonine-protein kinase 2 (Kinase)
Gene: RIPK2
UniProt: O43353 (RIPK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.51
Assay: Binding constant for RIPK2 kinase domain
Drug: dasatinib
Target: Ephrin type-B receptor 1 (Kinase)
Gene: EPHB1
UniProt: P54762 (EPHB1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 9.35
Assay: Binding constant for EPHB1 kinase domain
Drug: dasatinib
Target: Serine/threonine-protein kinase 4 (Kinase)
Gene: STK4
UniProt: Q13043 (STK4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.42
Assay: Binding constant for MST1 kinase domain
Drug: dasatinib
Target: Activated CDC42 kinase 1 (Kinase)
Gene: TNK2
UniProt: Q07912 (ACK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.25
Assay: Binding constant for TNK2 kinase domain
Drug: dasatinib
Target: STE20-like serine/threonine-protein kinase (Kinase)
Gene: SLK
UniProt: Q9H2G2 (SLK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.14
Assay: Binding constant for SLK kinase domain
Drug: dasatinib
Target: Epithelial discoidin domain-containing receptor 1 (Kinase)
Gene: DDR1
UniProt: Q08345 (DDR1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 9.16
Assay: Binding constant for DDR1 kinase domain
Drug: dasatinib
Target: Ephrin type-B receptor 4 (Kinase)
Gene: EPHB4
UniProt: P54760 (EPHB4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 9.47
Assay: Binding constant for EPHB4 kinase domain
Drug: dasatinib
Target: Activin receptor type-1B (Kinase)
Gene: ACVR1B
UniProt: P36896 (ACV1B_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.48
Assay: Binding constant for ACVR1B kinase domain
Drug: dasatinib
Target: Serine/threonine-protein kinase receptor R3 (Kinase)
Gene: ACVRL1
UniProt: P37023 (ACVL1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.34
Assay: Binding constant for ACVRL1 kinase domain
Drug: dasatinib
Target: Activin receptor type-1 (Kinase)
Gene: ACVR1
UniProt: Q04771 (ACVR1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.21
Assay: Binding constant for ACVR1 kinase domain
Drug: dasatinib
Target: TGF-beta receptor type-2 (Kinase)
Gene: TGFBR2
UniProt: P37173 (TGFR2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.54
Assay: Binding constant for TGFBR2 kinase domain
Drug: dasatinib
Target: Dual specificity mitogen-activated protein kinase kinase 1 (Kinase)
Gene: MAP2K1
UniProt: Q02750 (MP2K1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6
Assay: Binding constant for full-length MEK1
Drug: dasatinib
Target: Dual specificity mitogen-activated protein kinase kinase 2 (Kinase)
Gene: MAP2K2
UniProt: P36507 (MP2K2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.85
Assay: Binding constant for full-length MEK2
Drug: dasatinib
Target: Tyrosine-protein kinase ITK/TSK (Kinase)
Gene: ITK
UniProt: Q08881 (ITK_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.64
Assay: Inhibition of Itk F435T mutant
Drug: dasatinib
Target: Protein-tyrosine kinase 6 (Kinase)
Gene: PTK6
UniProt: Q13882 (PTK6_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.11
Assay: Binding constant for PTK6 kinase domain
Drug: dasatinib
Target: Proto-oncogene tyrosine-protein kinase LCK (Kinase)
Gene: Lck
UniProt: P06240 (LCK_MOUSE)
Organism: Mus musculus
Activity: Ki = 10.19
Assay: Inhibition of murine Lck in presence of ATP
Drug: dasatinib
Target: Tyrosine-protein kinase BTK (Kinase)
Gene: BTK
UniProt: Q06187 (BTK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.85
Assay: Binding constant for full-length BTK
Drug: dasatinib
Target: Tyrosine-protein kinase Tec (Kinase)
Gene: TEC
UniProt: P42680 (TEC_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.89
Assay: Binding constant for TEC kinase domain
Drug: dasatinib
Target: Ephrin type-B receptor 2 (Kinase)
Gene: EPHB2
UniProt: P29323 (EPHB2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 9.41
Assay: Binding constant for EPHB2 kinase domain
Drug: dasatinib
Target: Non-receptor tyrosine-protein kinase TYK2 (Kinase)
Gene: TYK2
UniProt: P29597 (TYK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.96
Assay: Binding constant for TYK2(JH2domain-pseudokinase) kinase domain
Drug: dasatinib
Target: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Kinase)
Gene: PIK3CA
UniProt: P42336 (PK3CA_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.42
Assay: Inhibition of recombinant PI3Kalpha by radioactive phosphotransfer assay in presence of 10 uM ATP
Drug: dasatinib
Target: Proto-oncogene tyrosine-protein kinase Src (Kinase)
Gene: SRC
UniProt: P00523 (SRC_CHICK)
Organism: Gallus gallus
Activity: Kd = 7.96
Assay: Activity of wild type chicken c N-terminal His-tagged Src expressed in Escherichia coli BL21 (DE3)
Drug: dasatinib
Target: Wee1-like protein kinase (Kinase)
Gene: WEE1
UniProt: P30291 (WEE1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.15
Assay: Binding constant for WEE1 kinase domain
Drug: dasatinib
Target: Serine/threonine-protein kinase 25 (Kinase)
Gene: STK25
UniProt: O00506 (STK25_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.47
Assay: Binding constant for YSK1 kinase domain
Drug: dasatinib
Target: Mitogen-activated protein kinase kinase kinase MLT (Kinase)
Gene: ZAK
UniProt: Q9NYL2 (MLTK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.35
Assay: Binding constant for ZAK kinase domain
Drug: dasatinib
Target: Tyrosine-protein kinase TXK (Kinase)
Gene: TXK
UniProt: P42681 (TXK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.68
Assay: Binding constant for TXK kinase domain
Drug: dasatinib
Target: LIM domain kinase 2 (Kinase)
Gene: LIMK2
UniProt: P53671 (LIMK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.07
Assay: Binding constant for full-length LIMK2
Drug: dasatinib
Target: Serine/threonine-protein kinase 26 (Kinase)
Gene: STK26
UniProt: Q9P289 (STK26_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.72
Assay: Binding constant for full-length MST4
Drug: dasatinib
Target: Serine/threonine-protein kinase NLK (Kinase)
Gene: NLK
UniProt: Q9UBE8 (NLK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.59
Assay: Binding constant for full-length NLK
Drug: dasatinib
Target: Eukaryotic translation initiation factor 2-alpha kinase 4 (Kinase)
Gene: EIF2AK4
UniProt: Q9P2K8 (E2AK4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.8
Assay: Binding constant for GCN2(Kin.Dom.2,S808G) kinase domain
Drug: dasatinib
Target: Serine/threonine-protein kinase SIK2 (Kinase)
Gene: SIK2
UniProt: Q9H0K1 (SIK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.19
Assay: Binding constant for full-length SNF1LK2
Drug: dasatinib
Target: Activin receptor type-2A (Kinase)
Gene: ACVR2A
UniProt: P27037 (AVR2A_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.68
Assay: Binding constant for ACVR2A kinase domain
Drug: dasatinib
Target: Activin receptor type-2B (Kinase)
Gene: ACVR2B
UniProt: Q13705 (AVR2B_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.24
Assay: Binding constant for ACVR2B kinase domain
Drug: dasatinib
Target: Serine/threonine-protein kinase TNNI3K (Kinase)
Gene: TNNI3K
UniProt: Q59H18 (TNI3K_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.96
Assay: Binding constant for full-length TNNI3K
Drug: dasatinib
Target: Discoidin domain-containing receptor 2 (Kinase)
Gene: DDR2
UniProt: Q16832 (DDR2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.52
Assay: Binding affinity to wild type DDR2 (unknown origin) by FLiK assay
Drug: dasatinib
Target: Myotonin-protein kinase (Kinase)
Gene: DMPK
UniProt: Q09013 (DMPK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.89
Assay: Binding constant for DMPK kinase domain
Drug: dasatinib
Target: Chaperone activity of bc1 complex-like, mitochondrial (Kinase)
Gene: COQ8A
UniProt: Q8NI60 (COQ8A_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.72
Assay: Binding constant for ADCK3 kinase domain
Drug: dasatinib
Target: Serine/threonine-protein kinase MRCK gamma (Kinase)
Gene: CDC42BPG
UniProt: Q6DT37 (MRCKG_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.92
Assay: Binding constant for DMPK2 kinase domain
Drug: dasatinib
Target: Mitogen-activated protein kinase kinase kinase kinase 1 (Kinase)
Gene: MAP4K1
UniProt: Q92918 (M4K1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.01
Assay: Binding constant for MAP4K1 kinase domain
Drug: dasatinib
Target: Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (Kinase)
Gene: PKMYT1
UniProt: Q99640 (PMYT1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.89
Assay: Binding constant for PKMYT1 kinase domain
Drug: dasatinib
Target: Mitogen-activated protein kinase kinase kinase kinase 3 (Kinase)
Gene: MAP4K3
UniProt: Q8IVH8 (M4K3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.19
Assay: Binding constant for MAP4K3 kinase domain
Drug: dasatinib
Target: Aurora kinase B (Kinase)
Gene: AURKB
UniProt: Q96GD4 (AURKB_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.19
Assay: Inhibition of AurB
Drug: dasatinib
Target: Tyrosine-protein kinase Blk (Kinase)
Gene: BLK
UniProt: P51451 (BLK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 9.68
Action type: INHIBITOR
Assay: Binding constant for BLK kinase domain
Drug: dasatinib
Target: Bone morphogenetic protein receptor type-1A (Kinase)
Gene: BMPR1A
UniProt: P36894 (BMR1A_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.15
Assay: Binding constant for BMPR1A kinase domain
Drug: dasatinib
Target: Mitogen-activated protein kinase kinase kinase kinase 4 (Kinase)
Gene: MAP4K4
UniProt: O95819 (M4K4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.51
Assay: Binding constant for MAP4K4 kinase domain
Drug: dasatinib
Target: Serine/threonine-protein kinase MRCK alpha (Kinase)
Gene: CDC42BPA
UniProt: Q5VT25 (MRCKA_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.7
Assay: Binding constant for MRCKA kinase domain
Drug: dasatinib
Target: Serine/threonine-protein kinase MRCK beta (Kinase)
Gene: CDC42BPB
UniProt: Q9Y5S2 (MRCKB_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.68
Assay: Binding constant for MRCKB kinase domain
Drug: dasatinib
Target: Serine/threonine-protein kinase SIK1 (Kinase)
Gene: SIK1
UniProt: P57059 (SIK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.41
Assay: Binding constant for SNF1LK kinase domain
Drug: dasatinib
Target: Tyrosine-protein kinase Srms (Kinase)
Gene: SRMS
UniProt: Q9H3Y6 (SRMS_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.89
Action type: INHIBITOR
Assay: Binding constant for SRMS kinase domain
Drug: dasatinib
Target: Dual specificity testis-specific protein kinase 1 (Kinase)
Gene: TESK1
UniProt: Q15569 (TESK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.48
Assay: Binding constant for TESK1 kinase domain
Drug: dasatinib
Target: TGF-beta receptor type-1 (Kinase)
Gene: TGFBR1
UniProt: P36897 (TGFR1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.64
Assay: Binding constant for TGFBR1 kinase domain
Drug: dasatinib
Target: Ephrin type-A receptor 1 (Kinase)
Gene: EPHA1
UniProt: P21709 (EPHA1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.39
Assay: Binding constant for EPHA1 kinase domain
Drug: dasatinib
Target: Ephrin type-B receptor 3 (Kinase)
Gene: EPHB3
UniProt: P54753 (EPHB3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.16
Assay: Binding constant for EPHB3 kinase domain
Drug: dasatinib
Target: Tubulin alpha-1A chain (Structural)
Gene: Tuba1a
UniProt: P68370 (TBA1A_RAT)
Organism: Rattus norvegicus
Activity: Kd = 7.26
Assay: Binding constant for ERBB4 kinase domain
Drug: dasatinib
Target: Mitogen-activated protein kinase kinase kinase kinase 2 (Kinase)
Gene: MAP4K2
UniProt: Q12851 (M4K2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.89
Assay: Binding constant for MAP4K2 kinase domain
Drug: dasatinib
Target: Misshapen-like kinase 1 (Kinase)
Gene: MINK1
UniProt: Q8N4C8 (MINK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.37
Assay: Binding constant for MINK kinase domain
Drug: dasatinib
Target: Tyrosine-protein kinase Blk (Kinase)
Gene: Blk
UniProt: P16277 (BLK_MOUSE)
Organism: Mus musculus
Activity: IC50 = 8.1
Assay: Inhibition of mouse BLK
Drug: dasatinib
Target: Ephrin type-B receptor 6 (Kinase)
Gene: EPHB6
UniProt: O15197 (EPHB6_HUMAN)
Organism: Homo sapiens
Activity: Kd = 10.41
Assay: Binding constant for EPHB6 kinase domain
Drug: dasatinib
Target: Mitogen-activated protein kinase kinase kinase 13 (Kinase)
Gene: MAP3K13
UniProt: O43283 (M3K13_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.28
Assay: Binding constant for LZK kinase domain
Drug: dasatinib
Target: Mitogen-activated protein kinase kinase kinase 2 (Kinase)
Gene: MAP3K2
UniProt: Q9Y2U5 (M3K2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.85
Assay: Binding constant for MAP3K2 kinase domain
Drug: dasatinib
Target: Mitogen-activated protein kinase kinase kinase 3 (Kinase)
Gene: MAP3K3
UniProt: Q99759 (M3K3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.55
Assay: Binding constant for MAP3K3 kinase domain
Drug: dasatinib
Target: Mitogen-activated protein kinase kinase kinase 7 (Kinase)
Gene: MAP3K7
UniProt: O43318 (M3K7_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.43
Assay: Binding constant for TAK1 kinase domain
Drug: dasatinib
Target: Serine/threonine-protein kinase TAO3 (Kinase)
Gene: TAOK3
UniProt: Q9H2K8 (TAOK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.64
Assay: Binding constant for TAOK3 kinase domain
Drug: dasatinib
Target: Serine/threonine-protein kinase ULK3 (Kinase)
Gene: ULK3
UniProt: Q6PHR2 (ULK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.34
Assay: Binding constant for ULK3 kinase domain
Drug: dasatinib
Target: Mitogen-activated protein kinase kinase kinase 19 (Kinase)
Gene: MAP3K19
UniProt: Q56UN5 (M3K19_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.1
Assay: Binding constant for YSK4 kinase domain
Drug: dasatinib
Target: Serine/threonine-protein kinase 35 (Kinase)
Gene: STK35
UniProt: Q8TDR2 (STK35_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.11
Assay: Binding constant for STK35 kinase domain
Drug: dasatinib
Target: Receptor tyrosine-protein kinase erbB-3 (Kinase)
Gene: ERBB3
UniProt: P21860 (ERBB3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.74
Assay: Binding constant for ERBB3 kinase domain
Drug: dasatinib
Target: Serine/threonine-protein kinase SIK3 (Kinase)
Gene: SIK3
UniProt: Q9Y2K2 (SIK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.55
Assay: Binding constant for QSK kinase domain
Drug: dasatinib
Target: Wee1-like protein kinase 2 (Kinase)
Gene: WEE2
UniProt: P0C1S8 (WEE2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.7
Assay: Binding constant for WEE2 kinase domain
Drug: dasatinib
Target: Bone morphogenetic protein receptor type-1B (Kinase)
Gene: BMPR1B
UniProt: O00238 (BMR1B_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.28
Assay: Binding constant for BMPR1B kinase domain
Drug: dasatinib
Target: Quinolone resistance protein NorA (Transporter)
Gene: norA
UniProt: P0A0J7 (NORA_STAAU)
Organism: Staphylococcus aureus
Activity: IC50 = 4.94
Assay: Inhibition of NorA in Staphylococcus aureus SA1199B harboring GrlA A116E mutant assessed as inhibition of ethidium bromide efflux after 5 mins by fluorometric method
Drug: dasatinib
Target: Serine/threonine-protein kinase SBK1 (Kinase)
Gene: SBK1
UniProt: Q52WX2 (SBK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.92
Assay: Binding constant for SBK1 kinase domain
Drug: dasatinib
Target: Serine/threonine-protein kinase VRK2 (Kinase)
Gene: VRK2
UniProt: Q86Y07 (VRK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.49
Assay: Binding constant for VRK2 kinase domain
Drug: dasatinib
Target: Serine/threonine-protein kinase TAO2 (Kinase)
Gene: TAOK2
UniProt: Q9UL54 (TAOK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.27
Assay: Binding constant for TAOK2 kinase domain
Drug: dasatinib
Target: Dual specificity mitogen-activated protein kinase kinase 5 (Kinase)
Gene: MAP2K5
UniProt: Q13163 (MP2K5_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.48
Assay: Binding constant for MEK5 kinase domain
Drug: dasatinib
Target: Serine/threonine-protein kinase Nek11 (Kinase)
Gene: NEK11
UniProt: Q8NG66 (NEK11_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.33
Assay: Binding constant for NEK11 kinase domain
Drug: dasatinib
Target: Calcium-dependent protein kinase 1 (Kinase)
Gene: CPK1
UniProt: P62344 (CDPK1_PLAF7)
Organism: Plasmodium falciparum
Activity: Kd = 6.19
Assay: Binding constant for PFCDPK1(P.falciparum) kinase domain
Drug: dasatinib
Target: MAP kinase p38 (Kinase)
Gene: MAPK13|MAPK12|MAPK11|MAPK14
UniProt: O15264|P53778|Q15759|Q16539 (MK13_HUMAN|MK12_HUMAN|MK11_HUMAN|MK14_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7
Assay: Inhibition of p38 kinase