AIM-Harvard/TrialPanorama-filtered huggingface dataset:
Drug: crizotinib
Target: Activated CDC42 kinase 1 (Kinase)
Gene: TNK2
UniProt: Q07912 (ACK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.12
Assay: Binding constant for TNK2 kinase domain
Drug: crizotinib
Target: Ephrin type-A receptor 7 (Kinase)
Gene: EPHA7
UniProt: Q15375 (EPHA7_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.33
Assay: Binding constant for EPHA7 kinase domain
Drug: crizotinib
Target: STE20-like serine/threonine-protein kinase (Kinase)
Gene: SLK
UniProt: Q9H2G2 (SLK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.74
Assay: Binding constant for SLK kinase domain
Drug: crizotinib
Target: Calcium/calmodulin-dependent protein kinase kinase 2 (Kinase)
Gene: CAMKK2
UniProt: Q96RR4 (KKCC2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.82
Assay: Binding constant for CAMKK2 kinase domain
Drug: crizotinib
Target: Epithelial discoidin domain-containing receptor 1 (Kinase)
Gene: DDR1
UniProt: Q08345 (DDR1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.29
Assay: Binding constant for DDR1 kinase domain
Drug: crizotinib
Target: Ephrin type-B receptor 4 (Kinase)
Gene: EPHB4
UniProt: P54760 (EPHB4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.24
Assay: Binding constant for EPHB4 kinase domain
Drug: crizotinib
Target: Activin receptor type-1B (Kinase)
Gene: ACVR1B
UniProt: P36896 (ACV1B_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.07
Assay: Binding constant for ACVR1B kinase domain
Drug: crizotinib
Target: Activin receptor type-1 (Kinase)
Gene: ACVR1
UniProt: Q04771 (ACVR1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.36
Assay: Binding constant for ACVR1 kinase domain
Drug: crizotinib
Target: Inhibitor of nuclear factor kappa-B kinase subunit beta (Kinase)
Gene: IKBKB
UniProt: O14920 (IKKB_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.26
Assay: Binding constant for IKK-beta kinase domain
Drug: crizotinib
Target: Tyrosine-protein kinase ITK/TSK (Kinase)
Gene: ITK
UniProt: Q08881 (ITK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.7
Assay: Binding constant for ITK kinase domain
Drug: crizotinib
Target: Tyrosine-protein kinase ZAP-70 (Kinase)
Gene: ZAP70
UniProt: P43403 (ZAP70_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.38
Assay: Binding constant for ZAP70 kinase domain
Drug: crizotinib
Target: Tyrosine-protein kinase BTK (Kinase)
Gene: BTK
UniProt: Q06187 (BTK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.11
Assay: Binding constant for BTK kinase domain
Drug: crizotinib
Target: Tyrosine-protein kinase receptor UFO (Kinase)
Gene: AXL
UniProt: P30530 (UFO_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.11
Assay: Binding constant for AXL kinase domain
Drug: crizotinib
Target: BDNF/NT-3 growth factors receptor (Kinase)
Gene: NTRK2
UniProt: Q16620 (NTRK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.43
Assay: Binding constant for TRKB kinase domain
Drug: crizotinib
Target: Tyrosine-protein kinase receptor TYRO3 (Kinase)
Gene: TYRO3
UniProt: Q06418 (TYRO3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.1
Assay: Binding constant for TYRO3 kinase domain
Drug: crizotinib
Target: Cyclin-dependent kinase 7 (Kinase)
Gene: CDK7
UniProt: P50613 (CDK7_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.48
Assay: Binding constant for CDK7 kinase domain
Drug: crizotinib
Target: Serine/threonine-protein kinase D1 (Kinase)
Gene: PRKD1
UniProt: Q15139 (KPCD1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6
Assay: Binding constant for PRKD1 kinase domain
Drug: crizotinib
Target: Ribosomal protein S6 kinase beta-1 (Kinase)
Gene: RPS6KB1
UniProt: P23443 (KS6B1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.19
Assay: Binding constant for S6K1 kinase domain
Drug: crizotinib
Target: Serine/threonine-protein kinase 3 (Kinase)
Gene: STK3
UniProt: Q13188 (STK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6
Assay: Binding constant for MST2 kinase domain
Drug: crizotinib
Target: NUAK family SNF1-like kinase 2 (Kinase)
Gene: NUAK2
UniProt: Q9H093 (NUAK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.92
Assay: Binding constant for SNARK kinase domain
Drug: crizotinib
Target: Non-receptor tyrosine-protein kinase TNK1 (Kinase)
Gene: TNK1
UniProt: Q13470 (TNK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.49
Assay: Binding constant for TNK1 kinase domain
Drug: crizotinib
Target: Non-receptor tyrosine-protein kinase TYK2 (Kinase)
Gene: TYK2
UniProt: P29597 (TYK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.68
Assay: Binding constant for TYK2(JH1domain-catalytic) kinase domain
Drug: crizotinib
Target: Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (Kinase)
Gene: PIP5K1A
UniProt: Q99755 (PI51A_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.49
Assay: Binding constant for PIP5K1A kinase domain
Drug: crizotinib
Target: Protein-tyrosine kinase 2-beta (Kinase)
Gene: PTK2B
UniProt: Q14289 (FAK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.72
Assay: Binding constant for PYK2 kinase domain
Drug: crizotinib
Target: Serine/threonine-protein kinase RIO1 (Kinase)
Gene: RIOK1
UniProt: Q9BRS2 (RIOK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.21
Assay: Binding constant for RIOK1 kinase domain
Drug: crizotinib
Target: Tyrosine-protein kinase receptor Tie-1 (Kinase)
Gene: TIE1
UniProt: P35590 (TIE1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.96
Assay: Binding constant for TIE1 kinase domain
Drug: crizotinib
Target: NT-3 growth factor receptor (Kinase)
Gene: NTRK3
UniProt: Q16288 (NTRK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.09
Assay: Binding constant for TRKC kinase domain
Drug: crizotinib
Target: Tyrosine-protein kinase TXK (Kinase)
Gene: TXK
UniProt: P42681 (TXK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.07
Assay: Binding constant for TXK kinase domain
Drug: crizotinib
Target: Inhibitor of nuclear factor kappa-B kinase subunit epsilon (Kinase)
Gene: IKBKE
UniProt: Q14164 (IKKE_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.15
Assay: Binding constant for IKK-epsilon kinase domain
Drug: crizotinib
Target: LIM domain kinase 2 (Kinase)
Gene: LIMK2
UniProt: P53671 (LIMK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.16
Assay: Binding constant for LIMK2 kinase domain
Drug: crizotinib
Target: Dual specificity mitogen-activated protein kinase kinase 3 (Kinase)
Gene: MAP2K3
UniProt: P46734 (MP2K3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.48
Assay: Binding constant for MEK3 kinase domain
Drug: crizotinib
Target: Serine/threonine-protein kinase 26 (Kinase)
Gene: STK26
UniProt: Q9P289 (STK26_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.55
Assay: Binding constant for MST4 kinase domain
Drug: crizotinib
Target: Serine/threonine-protein kinase Nek7 (Kinase)
Gene: NEK7
UniProt: Q8TDX7 (NEK7_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.24
Assay: Binding constant for NEK7 kinase domain
Drug: crizotinib
Target: Insulin receptor-related protein (Kinase)
Gene: INSRR
UniProt: P14616 (INSRR_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.22
Assay: Binding constant for INSRR kinase domain
Drug: crizotinib
Target: Interleukin-1 receptor-associated kinase 3 (Kinase)
Gene: IRAK3
UniProt: Q9Y616 (IRAK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.51
Assay: Binding constant for IRAK3 kinase domain
Drug: crizotinib
Target: Serine/threonine-protein kinase RIO3 (Kinase)
Gene: RIOK3
UniProt: O14730 (RIOK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.4
Assay: Binding constant for RIOK3 kinase domain
Drug: crizotinib
Target: Serine/threonine-protein kinase SIK2 (Kinase)
Gene: SIK2
UniProt: Q9H0K1 (SIK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.7
Assay: Binding constant for SIK2 kinase domain
Drug: crizotinib
Target: SRSF protein kinase 1 (Kinase)
Gene: SRPK1
UniProt: Q96SB4 (SRPK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.74
Assay: Binding constant for SRPK1 kinase domain
Drug: crizotinib
Target: Serine/threonine-protein kinase TNNI3K (Kinase)
Gene: TNNI3K
UniProt: Q59H18 (TNI3K_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.96
Assay: Binding constant for TNNI3K kinase domain
Drug: crizotinib
Target: Ankyrin repeat and protein kinase domain-containing protein 1 (Kinase)
Gene: ANKK1
UniProt: Q8NFD2 (ANKK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.11
Assay: Binding constant for ANKK1 kinase domain
Drug: crizotinib
Target: Myotonin-protein kinase (Kinase)
Gene: DMPK
UniProt: Q09013 (DMPK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.85
Assay: Binding constant for DMPK kinase domain
Drug: crizotinib
Target: Leukocyte tyrosine kinase receptor (Kinase)
Gene: LTK
UniProt: P29376 (LTK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.92
Assay: Binding constant for LTK kinase domain
Drug: crizotinib
Target: Mitogen-activated protein kinase kinase kinase kinase 1 (Kinase)
Gene: MAP4K1
UniProt: Q92918 (M4K1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.41
Assay: Binding constant for HPK1 kinase domain
Drug: crizotinib
Target: Mitogen-activated protein kinase kinase kinase kinase 3 (Kinase)
Gene: MAP4K3
UniProt: Q8IVH8 (M4K3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.12
Assay: Binding constant for MAP4K3 kinase domain
Drug: crizotinib
Target: Aurora kinase B (Kinase)
Gene: AURKB
UniProt: Q96GD4 (AURKB_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.12
Assay: Binding constant for AURKB kinase domain
Drug: crizotinib
Target: Tyrosine-protein kinase Blk (Kinase)
Gene: BLK
UniProt: P51451 (BLK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.96
Assay: Binding constant for BLK kinase domain
Drug: crizotinib
Target: Tyrosine-protein kinase Mer (Kinase)
Gene: MERTK
UniProt: Q12866 (MERTK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.44
Assay: Binding constant for MERTK kinase domain
Drug: crizotinib
Target: Cyclin-dependent kinase 11B (Kinase)
Gene: CDK11B
UniProt: P21127 (CD11B_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.12
Assay: Binding constant for CDC2L1 kinase domain
Drug: crizotinib
Target: Cyclin-dependent kinase 11A (Kinase)
Gene: CDK11A
UniProt: Q9UQ88 (CD11A_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.38
Assay: Binding constant for CDC2L2 kinase domain
Drug: crizotinib
Target: Muscle, skeletal receptor tyrosine-protein kinase (Kinase)
Gene: MUSK
UniProt: O15146 (MUSK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.64
Assay: Binding constant for MUSK kinase domain
Drug: crizotinib
Target: Serine/threonine-protein kinase DCLK1 (Kinase)
Gene: DCLK1
UniProt: O15075 (DCLK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.48
Assay: Binding constant for DCAMKL1 kinase domain
Drug: crizotinib
Target: Serine/threonine-protein kinase DCLK2 (Kinase)
Gene: DCLK2
UniProt: Q8N568 (DCLK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.43
Assay: Binding constant for DCAMKL2 kinase domain
Drug: crizotinib
Target: Serine/threonine-protein kinase Nek9 (Kinase)
Gene: NEK9
UniProt: Q8TD19 (NEK9_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.1
Assay: Binding constant for NEK9 kinase domain
Drug: crizotinib
Target: AarF domain-containing protein kinase 4 (Kinase)
Gene: COQ8B
UniProt: Q96D53 (COQ8B_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.96
Assay: Binding constant for ADCK4 kinase domain
Drug: crizotinib
Target: Dual specificity testis-specific protein kinase 1 (Kinase)
Gene: TESK1
UniProt: Q15569 (TESK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.42
Assay: Binding constant for TESK1 kinase domain
Drug: crizotinib
Target: TGF-beta receptor type-1 (Kinase)
Gene: TGFBR1
UniProt: P36897 (TGFR1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6
Assay: Binding constant for TGFBR1 kinase domain
Drug: crizotinib
Target: Ephrin type-A receptor 1 (Kinase)
Gene: EPHA1
UniProt: P21709 (EPHA1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.85
Assay: Binding constant for EPHA1 kinase domain
Drug: crizotinib
Target: Mitogen-activated protein kinase 7 (Kinase)
Gene: MAPK7
UniProt: Q13164 (MK07_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.29
Assay: Binding constant for ERK5 kinase domain
Drug: crizotinib
Target: Serine/threonine-protein kinase D3 (Kinase)
Gene: PRKD3
UniProt: O94806 (KPCD3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.29
Assay: Binding constant for PRKD3 kinase domain
Drug: crizotinib
Target: Interferon-induced, double-stranded RNA-activated protein kinase (Kinase)
Gene: EIF2AK2
UniProt: P19525 (E2AK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.96
Assay: Binding constant for PRKR kinase domain
Drug: crizotinib
Target: Receptor-interacting serine/threonine-protein kinase 1 (Kinase)
Gene: RIPK1
UniProt: Q13546 (RIPK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.8
Assay: Binding constant for RIPK1 kinase domain
Drug: crizotinib
Target: Tyrosine-protein kinase Fes/Fps (Kinase)
Gene: FES
UniProt: P07332 (FES_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.35
Assay: Binding constant for FES kinase domain
Drug: crizotinib
Target: Proto-oncogene tyrosine-protein kinase ROS (Kinase)
Gene: ROS1
UniProt: P08922 (ROS1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.39
Assay: Binding constant for ROS1 kinase domain
Drug: crizotinib
Target: Tyrosine-protein kinase ABL1 (Kinase)
Gene: Abl1
UniProt: P00520 (ABL1_MOUSE)
Organism: Mus musculus
Activity: IC50 = 5.94
Assay: Inhibition of ABL in mouse BaF3-BCL cells assessed as growth factor-induced autophosphorylation by sandwich ELISA method
Drug: crizotinib
Target: Mitogen-activated protein kinase kinase kinase kinase 2 (Kinase)
Gene: MAP4K2
UniProt: Q12851 (M4K2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.1
Assay: Binding constant for MAP4K2 kinase domain
Drug: crizotinib
Target: Misshapen-like kinase 1 (Kinase)
Gene: MINK1
UniProt: Q8N4C8 (MINK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.36
Assay: Binding constant for MINK kinase domain
Drug: crizotinib
Target: Serine/threonine-protein kinase TBK1 (Kinase)
Gene: TBK1
UniProt: Q9UHD2 (TBK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.16
Assay: Binding constant for TBK1 kinase domain
Drug: crizotinib
Target: Interleukin-1 receptor-associated kinase 4 (Kinase)
Gene: IRAK4
UniProt: Q9NWZ3 (IRAK4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.44
Assay: Binding constant for IRAK4 kinase domain
Drug: crizotinib
Target: Cyclin-dependent kinase-like 2 (Kinase)
Gene: CDKL2
UniProt: Q92772 (CDKL2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.68
Assay: Binding constant for CDKL2 kinase domain
Drug: crizotinib
Target: Dual specificity tyrosine-phosphorylation-regulated kinase 2 (Kinase)
Gene: DYRK2
UniProt: Q92630 (DYRK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.4
Assay: Binding constant for DYRK2 kinase domain
Drug: crizotinib
Target: Ephrin type-B receptor 6 (Kinase)
Gene: EPHB6
UniProt: O15197 (EPHB6_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.22
Assay: Binding constant for EPHB6 kinase domain
Drug: crizotinib
Target: G protein-coupled receptor kinase 4 (Kinase)
Gene: GRK4
UniProt: P32298 (GRK4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.38
Assay: Binding constant for GRK4 kinase domain
Drug: crizotinib
Target: Homeodomain-interacting protein kinase 4 (Kinase)
Gene: HIPK4
UniProt: Q8NE63 (HIPK4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.44
Assay: Binding constant for HIPK4 kinase domain
Drug: crizotinib
Target: Interleukin-1 receptor-associated kinase 1 (Kinase)
Gene: IRAK1
UniProt: P51617 (IRAK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.31
Assay: Binding constant for IRAK1 kinase domain
Drug: crizotinib
Target: Mitogen-activated protein kinase kinase kinase 13 (Kinase)
Gene: MAP3K13
UniProt: O43283 (M3K13_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.64
Assay: Binding constant for LZK kinase domain
Drug: crizotinib
Target: Mitogen-activated protein kinase kinase kinase 2 (Kinase)
Gene: MAP3K2
UniProt: Q9Y2U5 (M3K2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.14
Assay: Binding constant for MAP3K2 kinase domain
Drug: crizotinib
Target: Mitogen-activated protein kinase kinase kinase 3 (Kinase)
Gene: MAP3K3
UniProt: Q99759 (M3K3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.96
Assay: Binding constant for MAP3K3 kinase domain
Drug: crizotinib
Target: Serine/threonine-protein kinase NIM1 (Kinase)
Gene: NIM1K
UniProt: Q8IY84 (NIM1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.34
Assay: Binding constant for NIM1 kinase domain
Drug: crizotinib
Target: SRSF protein kinase 3 (Kinase)
Gene: SRPK3
UniProt: Q9UPE1 (SRPK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.09
Assay: Binding constant for SRPK3 kinase domain
Drug: crizotinib
Target: Mitogen-activated protein kinase kinase kinase 7 (Kinase)
Gene: MAP3K7
UniProt: O43318 (M3K7_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.74
Assay: Binding constant for TAK1 kinase domain
Drug: crizotinib
Target: Serine/threonine-protein kinase TAO1 (Kinase)
Gene: TAOK1
UniProt: Q7L7X3 (TAOK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.92
Assay: Binding constant for TAOK1 kinase domain
Drug: crizotinib
Target: Serine/threonine-protein kinase TAO3 (Kinase)
Gene: TAOK3
UniProt: Q9H2K8 (TAOK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.31
Assay: Binding constant for TAOK3 kinase domain
Drug: crizotinib
Target: Serine/threonine-protein kinase ULK1 (Kinase)
Gene: ULK1
UniProt: O75385 (ULK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6
Assay: Binding constant for ULK1 kinase domain
Drug: crizotinib
Target: Serine/threonine-protein kinase ULK2 (Kinase)
Gene: ULK2
UniProt: Q8IYT8 (ULK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.8
Assay: Binding constant for ULK2 kinase domain
Drug: crizotinib
Target: Serine/threonine-protein kinase ULK3 (Kinase)
Gene: ULK3
UniProt: Q6PHR2 (ULK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.17
Assay: Binding constant for ULK3 kinase domain
Drug: crizotinib
Target: Mitogen-activated protein kinase kinase kinase 19 (Kinase)
Gene: MAP3K19
UniProt: Q56UN5 (M3K19_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.01
Assay: Binding constant for YSK4 kinase domain
Drug: crizotinib
Target: Mitogen-activated protein kinase kinase kinase 15 (Kinase)
Gene: MAP3K15
UniProt: Q6ZN16 (M3K15_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.55
Assay: Binding constant for MAP3K15 kinase domain
Drug: crizotinib
Target: Receptor-interacting serine/threonine-protein kinase 4 (Kinase)
Gene: RIPK4
UniProt: P57078 (RIPK4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.68
Assay: Binding constant for RIPK4 kinase domain
Drug: crizotinib
Target: Uncharacterized serine/threonine-protein kinase SBK3 (Kinase)
Gene: SBK3
UniProt: P0C264 (SBK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.62
Assay: Binding constant for SgK110 kinase domain
Drug: crizotinib
Target: Serine/threonine-protein kinase 35 (Kinase)
Gene: STK35
UniProt: Q8TDR2 (STK35_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.21
Assay: Binding constant for STK35 kinase domain
Drug: crizotinib
Target: Mitogen-activated protein kinase kinase kinase 1 (Kinase)
Gene: MAP3K1
UniProt: Q13233 (M3K1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.96
Assay: Binding constant for MAP3K1 kinase domain
Drug: crizotinib
Target: Bone morphogenetic protein receptor type-1B (Kinase)
Gene: BMPR1B
UniProt: O00238 (BMR1B_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.64
Assay: Binding constant for BMPR1B kinase domain
Drug: crizotinib
Target: Macrophage-stimulating protein receptor (Kinase)
Gene: Mst1r
UniProt: Q62190 (RON_MOUSE)
Organism: Mus musculus
Activity: IC50 = 7.1
Assay: Inhibition of RON in mouse 3T3 cells assessed as growth factor-induced autophosphorylation by sandwich ELISA method
Drug: crizotinib
Target: Angiopoietin-1 receptor (Kinase)
Gene: Tek
UniProt: Q02858 (TIE2_MOUSE)
Organism: Mus musculus
Activity: IC50 = 6.35
Assay: Inhibition of TIE2 in mouse 3T3-E cells assessed growth factor-induced autophosphorylation by sandwich ELISA method
Drug: crizotinib
Target: Serine/threonine-protein kinase SBK1 (Kinase)
Gene: SBK1
UniProt: Q52WX2 (SBK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.89
Assay: Binding constant for SBK1 kinase domain
Drug: crizotinib
Target: Peripheral plasma membrane protein CASK (Kinase)
Gene: CASK
UniProt: O14936 (CSKP_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.85
Assay: Binding constant for CASK kinase domain
Drug: crizotinib
Target: Mitogen-activated protein kinase kinase kinase 12 (Kinase)
Gene: MAP3K12
UniProt: Q12852 (M3K12_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.77
Assay: Binding constant for DLK kinase domain
Drug: crizotinib
Target: Serine/threonine-protein kinase TAO2 (Kinase)
Gene: TAOK2
UniProt: Q9UL54 (TAOK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.05
Assay: Binding constant for TAOK2 kinase domain
Drug: crizotinib
Target: Dual serine/threonine and tyrosine protein kinase (Kinase)
Gene: DSTYK
UniProt: Q6XUX3 (DUSTY_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.35
Assay: Binding constant for RIPK5 kinase domain
Drug: crizotinib
Target: NPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor) (Kinase)
Gene: NPM1|ALK
UniProt: P06748|Q9UM73 (NPM_HUMAN|ALK_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7.29
Assay: Inhibition of NPM/ALK (unknown origin) transfected in mouse BAF3 cells assessed as cell growth inhibition after 72 hrs by [3H]-thymidine incorporation assay
Drug: crizotinib
Target: Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (Enzyme)
Gene: INPPL1
UniProt: O15357 (SHIP2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.26
Assay: Inhibition of SHIP2 (unknown origin) assessed as decrease in PIP2 production using PtdIns(3,4,5)P3 as substrate preincubated for 20 mins followed by substrate addition measured for 50 mins by malachite green staining based assay
Drug: crizotinib
Target: Receptor-interacting serine/threonine-protein kinase 3 (Kinase)
Gene: RIPK3
UniProt: Q9Y572 (RIPK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.17
Assay: Binding affinity to human RIPK3 by kinome scan based method
Drug: crizotinib
Target: Mixed lineage kinase domain-like protein (Kinase)
Gene: MLKL
UniProt: Q8NB16 (MLKL_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.66
Assay: Binding affinity to human MLKL by kinome scan based method
Drug: deferiprone
Target: Deoxyhypusine hydroxylase (Enzyme)
Gene: DOHH
UniProt: Q9BU89 (DOHH_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.3
Assay: Inhibition of DOHH (unknown origin)
Drug: hydroxyprogesterone caproate
Target: Glucocorticoid receptor (Nuclear hormone receptor)
Gene: NR3C1
UniProt: P04150 (GCR_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.638
Assay: DRUGMATRIX: Glucocorticoid radioligand binding (ligand: [3H] Dexamethasone)
Drug: hydroxyprogesterone caproate
Target: Sodium-dependent dopamine transporter (Transporter)
Gene: SLC6A3
UniProt: Q01959 (SC6A3_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.261
Assay: DRUGMATRIX: Dopamine Transporter radioligand binding (ligand: [125I] RTI-55)
Drug: hydroxyprogesterone caproate
Target: Adenosine receptor A3 (GPCR)
Gene: ADORA3
UniProt: P0DMS8 (AA3R_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.573
Assay: DRUGMATRIX: Adenosine A3 radioligand binding (ligand: AB-MECA)
Drug: hydroxyprogesterone caproate
Target: Corticosteroid-binding globulin (Secreted)
Gene: SERPINA6
UniProt: P08185 (CBG_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.74
Drug: hydroxyprogesterone caproate
Target: Sex hormone-binding globulin (Secreted)
Gene: SHBG
UniProt: P04278 (SHBG_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7
Assay: Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulin
Drug: hydroxyprogesterone caproate
Target: Mitogen-activated protein kinase 3 (Kinase)
Gene: MAPK3
UniProt: P27361 (MK03_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.501
Assay: DRUGMATRIX: Protein Serine/Threonine Kinase, ERK1 enzyme inhibition (substrate: Myelin Basic Protein)
Drug: hydroxyprogesterone caproate
Target: Androgen receptor (Transcription factor)
Gene: Ar
UniProt: P15207 (ANDR_RAT)
Organism: Rattus norvegicus
Activity: Ki = 6.307
Assay: DRUGMATRIX: Androgen (Testosterone) AR radioligand binding (ligand: [3H] Mibolerone)
Drug: hydroxyprogesterone caproate
Target: Progesterone receptor (Transcription factor)
Gene: PGR
UniProt: Q690N0 (Q690N0_BOVIN)
Organism: Bos taurus
Activity: Ki = 8.81
Assay: DRUGMATRIX: Progesterone radioligand binding (ligand: [3H] R-5020)
Drug: hydroxyprogesterone caproate
Target: Progesterone receptor (Nuclear hormone receptor)
Gene: PGR
UniProt: P06401 (PRGR_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7.664
Action type: AGONIST
Assay: human recombinant PR-B isoform in Sf9 cells
Drug: ruxolitinib
Target: Tyrosine-protein kinase JAK3 (Kinase)
Gene: JAK3
UniProt: P52333 (JAK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.7
Assay: Binding constant for JAK3(JH1domain-catalytic) kinase domain