AIM-Harvard/TrialPanorama-filtered huggingface dataset:
Drug: sunitinib
Target: Dual specificity protein kinase CLK1 (Kinase)
Gene: CLK1
UniProt: P49759 (CLK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.66
Assay: Binding constant for full-length CLK1
Drug: sunitinib
Target: Dual specificity protein kinase CLK2 (Kinase)
Gene: CLK2
UniProt: P49760 (CLK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.7
Assay: Binding constant for CLK2 kinase domain
Drug: sunitinib
Target: Serine/threonine-protein kinase 38-like (Kinase)
Gene: STK38L
UniProt: Q9Y2H1 (ST38L_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.01
Assay: Binding constant for NDR2 kinase domain
Drug: sunitinib
Target: Mitogen-activated protein kinase kinase kinase kinase 5 (Kinase)
Gene: MAP4K5
UniProt: Q9Y4K4 (M4K5_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.39
Assay: Binding constant for MAP4K5 kinase domain
Drug: sunitinib
Target: Mitogen-activated protein kinase kinase kinase 4 (Kinase)
Gene: MAP3K4
UniProt: Q9Y6R4 (M3K4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.48
Assay: Average Binding Constant for MAP3K4; NA=Not Active at 10 uM
Drug: sunitinib
Target: Cyclin-G-associated kinase (Kinase)
Gene: GAK
UniProt: O14976 (GAK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.7
Assay: Binding constant for GAK kinase domain
Drug: sunitinib
Target: Ephrin type-B receptor 1 (Kinase)
Gene: EPHB1
UniProt: P54762 (EPHB1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.32
Assay: Binding constant for EPHB1 kinase domain
Drug: sunitinib
Target: Calcium/calmodulin-dependent protein kinase type 1D (Kinase)
Gene: CAMK1D
UniProt: Q8IU85 (KCC1D_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.29
Assay: Binding constant for CAMK1D kinase domain
Drug: sunitinib
Target: Cyclin-dependent kinase 16 (Kinase)
Gene: CDK16
UniProt: Q00536 (CDK16_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.89
Assay: Average Binding Constant for PCTK1; NA=Not Active at 10 uM
Drug: sunitinib
Target: Serine/threonine-protein kinase 4 (Kinase)
Gene: STK4
UniProt: Q13043 (STK4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.72
Assay: Binding constant for full-length MST1
Drug: sunitinib
Target: Activated CDC42 kinase 1 (Kinase)
Gene: TNK2
UniProt: Q07912 (ACK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.66
Assay: Average Binding Constant for ACK1; NA=Not Active at 10 uM
Drug: sunitinib
Target: Ribosomal protein S6 kinase alpha-5 (Kinase)
Gene: RPS6KA5
UniProt: O75582 (KS6A5_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.77
Assay: Binding affinity to RPS6KA2(Kin.Dom.1-N-terminal)
Drug: sunitinib
Target: STE20-like serine/threonine-protein kinase (Kinase)
Gene: SLK
UniProt: Q9H2G2 (SLK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.25
Assay: Binding constant for SLK kinase domain
Drug: sunitinib
Target: Dual specificity protein kinase CLK4 (Kinase)
Gene: CLK4
UniProt: Q9HAZ1 (CLK4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.54
Assay: Binding constant for CLK4 kinase domain
Drug: sunitinib
Target: MAP kinase-interacting serine/threonine-protein kinase 2 (Kinase)
Gene: MKNK2
UniProt: Q9HBH9 (MKNK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.24
Assay: Binding constant for MKNK2 kinase domain
Drug: sunitinib
Target: Mitogen-activated protein kinase 9 (Kinase)
Gene: MAPK9
UniProt: P45984 (MK09_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.62
Assay: Binding constant for JNK2 kinase domain
Drug: sunitinib
Target: Calcium/calmodulin-dependent protein kinase kinase 2 (Kinase)
Gene: CAMKK2
UniProt: Q96RR4 (KKCC2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.82
Assay: Binding constant for CAMKK2 kinase domain
Drug: sunitinib
Target: MAP/microtubule affinity-regulating kinase 3 (Kinase)
Gene: MARK3
UniProt: P27448 (MARK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.39
Assay: Binding constant for full-length MARK3
Drug: sunitinib
Target: Calcium/calmodulin-dependent protein kinase kinase 1 (Kinase)
Gene: CAMKK1
UniProt: Q8N5S9 (KKCC1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.38
Assay: Binding constant for CAMKK1 kinase domain
Drug: sunitinib
Target: Calcium/calmodulin-dependent protein kinase type 1G (Kinase)
Gene: CAMK1G
UniProt: Q96NX5 (KCC1G_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.36
Assay: Binding constant for CAMK1G kinase domain
Drug: sunitinib
Target: Epithelial discoidin domain-containing receptor 1 (Kinase)
Gene: DDR1
UniProt: Q08345 (DDR1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.7
Assay: Binding constant for DDR1 kinase domain
Drug: sunitinib
Target: Solute carrier family 22 member 1 (Transporter)
Gene: SLC22A1
UniProt: O15245 (S22A1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.21
Assay: Inhibition of human OCT1 expressed in HEK293 cells assessed as decrease in uptake of ASP+ after 2 mins by fluorescence assay
Drug: sunitinib
Target: Testis-specific serine/threonine-protein kinase 1 (Kinase)
Gene: TSSK1B
UniProt: Q9BXA7 (TSSK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.2
Assay: Binding constant for full-length TSSK1
Drug: sunitinib
Target: 3-phosphoinositide-dependent protein kinase 1 (Kinase)
Gene: PDPK1
UniProt: O15530 (PDPK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.46
Assay: Binding constant for full-length PDPK1
Drug: sunitinib
Target: Dual specificity mitogen-activated protein kinase kinase 1 (Kinase)
Gene: MAP2K1
UniProt: Q02750 (MP2K1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.89
Assay: Binding constant for full-length MEK1
Drug: sunitinib
Target: Dual specificity mitogen-activated protein kinase kinase 2 (Kinase)
Gene: MAP2K2
UniProt: P36507 (MP2K2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.96
Assay: Binding constant for full-length MEK2
Drug: sunitinib
Target: Tyrosine-protein kinase ITK/TSK (Kinase)
Gene: ITK
UniProt: Q08881 (ITK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.89
Assay: Binding constant for ITK kinase domain
Drug: sunitinib
Target: Serine/threonine-protein kinase 3 (Kinase)
Gene: Stk3
UniProt: Q9JI10 (STK3_MOUSE)
Organism: Mus musculus
Activity: Kd = 6.8
Assay: Average Binding Constant for STK3_m; NA=Not Active at 10 uM
Drug: sunitinib
Target: Serine/threonine-protein kinase ULK3 (Kinase)
Gene: Ulk3
UniProt: Q3U3Q1 (ULK3_MOUSE)
Organism: Mus musculus
Activity: Kd = 6.96
Assay: Average Binding Constant for ULK3 m; NA=Not Active at 10 uM
Drug: sunitinib
Target: Protein-tyrosine kinase 6 (Kinase)
Gene: PTK6
UniProt: Q13882 (PTK6_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.34
Assay: Binding constant for BRK kinase domain
Drug: sunitinib
Target: Tyrosine-protein kinase BTK (Kinase)
Gene: BTK
UniProt: Q06187 (BTK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.68
Assay: Binding constant for BTK kinase domain
Drug: sunitinib
Target: Tyrosine-protein kinase receptor UFO (Kinase)
Gene: AXL
UniProt: P30530 (UFO_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.05
Assay: Binding constant for AXL kinase domain
Drug: sunitinib
Target: BDNF/NT-3 growth factors receptor (Kinase)
Gene: NTRK2
UniProt: Q16620 (NTRK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.23
Assay: Binding constant for TRKB kinase domain
Drug: sunitinib
Target: Tyrosine-protein kinase receptor TYRO3 (Kinase)
Gene: TYRO3
UniProt: Q06418 (TYRO3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.31
Assay: Binding constant for TYRO3 kinase domain
Drug: sunitinib
Target: Cyclin-dependent kinase 7 (Kinase)
Gene: CDK7
UniProt: P50613 (CDK7_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.48
Assay: Binding constant for full-length CDK7
Drug: sunitinib
Target: Serine/threonine-protein kinase D1 (Kinase)
Gene: PRKD1
UniProt: Q15139 (KPCD1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.51
Assay: Binding constant for PRKD1 kinase domain
Drug: sunitinib
Target: Ribosomal protein S6 kinase beta-1 (Kinase)
Gene: RPS6KB1
UniProt: P23443 (KS6B1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.32
Assay: Binding constant for S6K1 kinase domain
Drug: sunitinib
Target: Serine/threonine-protein kinase N2 (Kinase)
Gene: PKN2
UniProt: Q16513 (PKN2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.89
Assay: Binding constant for PKN2 kinase domain
Drug: sunitinib
Target: RAC-beta serine/threonine-protein kinase (Kinase)
Gene: AKT2
UniProt: P31751 (AKT2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.57
Assay: Binding constant for AKT2 kinase domain
Drug: sunitinib
Target: Serine/threonine-protein kinase DCLK3 (Kinase)
Gene: DCLK3
UniProt: Q9C098 (DCLK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.96
Assay: Binding constant for DCAMKL3 kinase domain
Drug: sunitinib
Target: Serine/threonine-protein kinase 3 (Kinase)
Gene: STK3
UniProt: Q13188 (STK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.25
Assay: Binding constant for MST2 kinase domain
Drug: sunitinib
Target: Ribosomal protein S6 kinase alpha-6 (Kinase)
Gene: RPS6KA6
UniProt: Q9UK32 (KS6A6_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.62
Assay: Binding constant for RPS6KA6(Kin.Dom.1 - C-terminal) kinase domain
Drug: sunitinib
Target: NUAK family SNF1-like kinase 2 (Kinase)
Gene: NUAK2
UniProt: Q9H093 (NUAK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.82
Assay: Binding constant for SNARK kinase domain
Drug: sunitinib
Target: Non-receptor tyrosine-protein kinase TNK1 (Kinase)
Gene: TNK1
UniProt: Q13470 (TNK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.17
Assay: Binding constant for full-length TNK1
Drug: sunitinib
Target: Non-receptor tyrosine-protein kinase TYK2 (Kinase)
Gene: TYK2
UniProt: P29597 (TYK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.44
Assay: Binding affinity to TYK2(JH2domain-pseudokinase)
Drug: sunitinib
Target: Serine/threonine-protein kinase Chk1 (Kinase)
Gene: CHEK1
UniProt: O14757 (CHK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.52
Assay: Binding constant for CHEK1 kinase domain
Drug: sunitinib
Target: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Kinase)
Gene: PIK3CA
UniProt: P42336 (PK3CA_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.96
Assay: Inhibition of recombinant PI3Kalpha by radioactive phosphotransfer assay in presence of 10 uM ATP
Drug: sunitinib
Target: Proto-oncogene tyrosine-protein kinase Src (Kinase)
Gene: SRC
UniProt: P00523 (SRC_CHICK)
Organism: Gallus gallus
Activity: IC50 = 6.26
Assay: Inhibition of chicken wild-type cSRC (251 to 533)-mediated phosphorylation of biotinylated poly-Glu-Tyr expressed in Escherichia coli BL21(DE3) preincubated for 30 to 60 mins prior to substrate addition by TR-FRET assay
Drug: sunitinib
Target: Serine/threonine-protein kinase PAK 3 (Kinase)
Gene: PAK3
UniProt: O75914 (PAK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.8
Assay: Binding constant for full-length PAK3
Drug: sunitinib
Target: Cyclin-dependent kinase 17 (Kinase)
Gene: CDK17
UniProt: Q00537 (CDK17_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.92
Assay: Binding constant for full-length PCTK2
Drug: sunitinib
Target: Cyclin-dependent kinase 18 (Kinase)
Gene: CDK18
UniProt: Q07002 (CDK18_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.77
Assay: Binding constant for full-length PCTK3
Drug: sunitinib
Target: Cyclin-dependent kinase 14 (Kinase)
Gene: CDK14
UniProt: O94921 (CDK14_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.57
Assay: Binding constant for full-length PFTK1
Drug: sunitinib
Target: Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (Kinase)
Gene: PIP5K1A
UniProt: Q99755 (PI51A_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.27
Assay: Binding constant for full-length PIP5K1A
Drug: sunitinib
Target: Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (Kinase)
Gene: PIP4K2B
UniProt: P78356 (PI42B_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.41
Assay: Binding constant for full-length PIP5K2B
Drug: sunitinib
Target: Myosin light chain kinase family member 4 (Kinase)
Gene: MYLK4
UniProt: Q86YV6 (MYLK4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.82
Assay: Binding constant for SgK085 kinase domain
Drug: sunitinib
Target: Wee1-like protein kinase (Kinase)
Gene: WEE1
UniProt: P30291 (WEE1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.96
Assay: Binding constant for WEE1 kinase domain
Drug: sunitinib
Target: Serine/threonine-protein kinase 25 (Kinase)
Gene: STK25
UniProt: O00506 (STK25_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.54
Assay: Binding constant for YSK1 kinase domain
Drug: sunitinib
Target: Protein-tyrosine kinase 2-beta (Kinase)
Gene: PTK2B
UniProt: Q14289 (FAK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.09
Assay: Binding constant for full-length PTK2B
Drug: sunitinib
Target: Serine/threonine-protein kinase RIO1 (Kinase)
Gene: RIOK1
UniProt: Q9BRS2 (RIOK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.46
Assay: Binding constant for full-length RIOK1
Drug: sunitinib
Target: Casein kinase I isoform alpha-like (Kinase)
Gene: CSNK1A1L
UniProt: Q8N752 (KC1AL_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.26
Assay: Binding constant for full-length CSNK1A1L
Drug: sunitinib
Target: Casein kinase I isoform delta (Kinase)
Gene: CSNK1D
UniProt: P48730 (KC1D_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.82
Assay: Binding constant for full-length CSNK1D
Drug: sunitinib
Target: Casein kinase I isoform gamma-2 (Kinase)
Gene: CSNK1G2
UniProt: P78368 (KC1G2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.96
Assay: Binding constant for full-length CSNK1G2
Drug: sunitinib
Target: Casein kinase I isoform gamma-3 (Kinase)
Gene: CSNK1G3
UniProt: Q9Y6M4 (KC1G3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.62
Assay: Binding constant for full-length CSNK1G3
Drug: sunitinib
Target: Tyrosine-protein kinase receptor Tie-1 (Kinase)
Gene: TIE1
UniProt: P35590 (TIE1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.41
Assay: Binding constant for TIE1 kinase domain
Drug: sunitinib
Target: Serine/threonine-protein kinase tousled-like 1 (Kinase)
Gene: TLK1
UniProt: Q9UKI8 (TLK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.13
Assay: Binding constant for TLK1 kinase domain
Drug: sunitinib
Target: Serine/threonine-protein kinase tousled-like 2 (Kinase)
Gene: TLK2
UniProt: Q86UE8 (TLK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.48
Assay: Binding constant for TLK2 kinase domain
Drug: sunitinib
Target: NT-3 growth factor receptor (Kinase)
Gene: NTRK3
UniProt: Q16288 (NTRK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.29
Assay: Binding constant for TRKC kinase domain
Drug: sunitinib
Target: Casein kinase II subunit alpha (Kinase)
Gene: CSNK2A1
UniProt: P68400 (CSK21_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.09
Assay: Binding constant for full-length CSNK2A1
Drug: sunitinib
Target: Casein kinase II subunit alpha' (Kinase)
Gene: CSNK2A2
UniProt: P19784 (CSK22_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.8
Assay: Binding constant for CSNK2A2 kinase domain
Drug: sunitinib
Target: Dual specificity tyrosine-phosphorylation-regulated kinase 1B (Kinase)
Gene: DYRK1B
UniProt: Q9Y463 (DYR1B_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.64
Assay: Binding constant for full-length DYRK1B
Drug: sunitinib
Target: Inhibitor of nuclear factor kappa-B kinase subunit epsilon (Kinase)
Gene: IKBKE
UniProt: Q14164 (IKKE_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.21
Assay: Binding constant for full-length IKK-epsilon
Drug: sunitinib
Target: Serine/threonine-protein kinase STK11 (Kinase)
Gene: STK11
UniProt: Q15831 (STK11_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.42
Assay: Binding constant for full-length LKB1
Drug: sunitinib
Target: Dual specificity mitogen-activated protein kinase kinase 3 (Kinase)
Gene: MAP2K3
UniProt: P46734 (MP2K3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.77
Assay: Binding constant for MEK3 kinase domain
Drug: sunitinib
Target: Maternal embryonic leucine zipper kinase (Kinase)
Gene: MELK
UniProt: Q14680 (MELK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.46
Assay: Binding constant for full-length MELK
Drug: sunitinib
Target: MAP kinase-interacting serine/threonine-protein kinase 1 (Kinase)
Gene: MKNK1
UniProt: Q9BUB5 (MKNK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.41
Assay: Binding constant for MKNK1 kinase domain
Drug: sunitinib
Target: Serine/threonine-protein kinase 26 (Kinase)
Gene: STK26
UniProt: Q9P289 (STK26_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.47
Assay: Binding constant for full-length MST4
Drug: sunitinib
Target: Serine/threonine-protein kinase Nek7 (Kinase)
Gene: NEK7
UniProt: Q8TDX7 (NEK7_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.39
Assay: Binding constant for full-length NEK7
Drug: sunitinib
Target: Eukaryotic translation initiation factor 2-alpha kinase 4 (Kinase)
Gene: EIF2AK4
UniProt: Q9P2K8 (E2AK4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.74
Assay: Binding constant for GCN2(Kin.Dom.2,S808G) kinase domain
Drug: sunitinib
Target: Insulin receptor-related protein (Kinase)
Gene: INSRR
UniProt: P14616 (INSRR_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.37
Assay: Binding constant for INSRR kinase domain
Drug: sunitinib
Target: Interleukin-1 receptor-associated kinase 3 (Kinase)
Gene: IRAK3
UniProt: Q9Y616 (IRAK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.03
Assay: Binding constant for IRAK3 kinase domain
Drug: sunitinib
Target: Serine/threonine-protein kinase RIO3 (Kinase)
Gene: RIOK3
UniProt: O14730 (RIOK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.42
Assay: Binding constant for full-length RIOK3
Drug: sunitinib
Target: Serine/threonine-protein kinase SIK2 (Kinase)
Gene: SIK2
UniProt: Q9H0K1 (SIK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.24
Assay: Binding constant for full-length SNF1LK2
Drug: sunitinib
Target: SRSF protein kinase 1 (Kinase)
Gene: SRPK1
UniProt: Q96SB4 (SRPK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.6
Assay: Binding constant for full-length SRPK1
Drug: sunitinib
Target: SRSF protein kinase 2 (Kinase)
Gene: SRPK2
UniProt: P78362 (SRPK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.72
Assay: Binding constant for full-length SRPK2
Drug: sunitinib
Target: Serine/threonine-protein kinase 33 (Kinase)
Gene: STK33
UniProt: Q9BYT3 (STK33_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.77
Assay: Binding constant for full-length STK33
Drug: sunitinib
Target: 5'-AMP-activated protein kinase catalytic subunit alpha-2 (Kinase)
Gene: PRKAA2
UniProt: P54646 (AAPK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.05
Assay: Binding constant for AMPK-alpha2 kinase domain
Drug: sunitinib
Target: Ankyrin repeat and protein kinase domain-containing protein 1 (Kinase)
Gene: ANKK1
UniProt: Q8NFD2 (ANKK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.51
Assay: Binding constant for ANKK1 kinase domain
Drug: sunitinib
Target: Discoidin domain-containing receptor 2 (Kinase)
Gene: DDR2
UniProt: Q16832 (DDR2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.54
Assay: Binding constant for DDR2 kinase domain
Drug: sunitinib
Target: Serine/threonine-protein kinase LATS1 (Kinase)
Gene: LATS1
UniProt: O95835 (LATS1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.2
Assay: Binding constant for LATS1 kinase domain
Drug: sunitinib
Target: Serine/threonine-protein kinase LATS2 (Kinase)
Gene: LATS2
UniProt: Q9NRM7 (LATS2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.34
Assay: Binding constant for LATS2 kinase domain
Drug: sunitinib
Target: Leukocyte tyrosine kinase receptor (Kinase)
Gene: LTK
UniProt: P29376 (LTK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.74
Assay: Binding constant for LTK kinase domain
Drug: sunitinib
Target: Mitogen-activated protein kinase kinase kinase kinase 1 (Kinase)
Gene: MAP4K1
UniProt: Q92918 (M4K1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.8
Assay: Binding constant for MAP4K1 kinase domain
Drug: sunitinib
Target: Serine/threonine-protein kinase PAK 6 (Kinase)
Gene: PAK6
UniProt: Q9NQU5 (PAK6_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.62
Assay: Binding constant for PAK6 kinase domain
Drug: sunitinib
Target: Serine/threonine-protein kinase PAK 7 (Kinase)
Gene: PAK5
UniProt: Q9P286 (PAK5_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.19
Assay: Binding constant for PAK7/PAK5 kinase domain
Drug: sunitinib
Target: NUAK family SNF1-like kinase 1 (Kinase)
Gene: NUAK1
UniProt: O60285 (NUAK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.32
Assay: Binding constant for ARK5 kinase domain
Drug: sunitinib
Target: Serine/threonine-protein kinase pim-3 (Kinase)
Gene: PIM3
UniProt: Q86V86 (PIM3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.62
Assay: Binding constant for PIM3 kinase domain
Drug: sunitinib
Target: Mitogen-activated protein kinase kinase kinase kinase 3 (Kinase)
Gene: MAP4K3
UniProt: Q8IVH8 (M4K3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.74
Assay: Binding constant for MAP4K3 kinase domain
Drug: sunitinib
Target: Aurora kinase B (Kinase)
Gene: AURKB
UniProt: Q96GD4 (AURKB_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.42
Assay: Binding constant for AURKB kinase domain
Drug: sunitinib
Target: Tyrosine-protein kinase Blk (Kinase)
Gene: BLK
UniProt: P51451 (BLK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.19
Assay: Binding constant for BLK kinase domain
Drug: sunitinib
Target: Bone morphogenetic protein receptor type-2 (Kinase)
Gene: BMPR2
UniProt: Q13873 (BMPR2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.24
Assay: Binding constant for BMPR2 kinase domain
Drug: sunitinib
Target: Serine/threonine-protein kinase BRSK1 (Kinase)
Gene: BRSK1
UniProt: Q8TDC3 (BRSK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.46
Assay: Binding constant for BRSK1 kinase domain
Drug: sunitinib
Target: Mitogen-activated protein kinase kinase kinase kinase 4 (Kinase)
Gene: MAP4K4
UniProt: O95819 (M4K4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.85
Assay: Binding constant for MAP4K4 kinase domain
Drug: sunitinib
Target: Serine/threonine-protein kinase MARK1 (Kinase)
Gene: MARK1
UniProt: Q9P0L2 (MARK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.92
Assay: Binding constant for MARK1 kinase domain
Drug: sunitinib
Target: MAP/microtubule affinity-regulating kinase 4 (Kinase)
Gene: MARK4
UniProt: Q96L34 (MARK4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.44
Assay: Binding constant for MARK4 kinase domain
Drug: sunitinib
Target: Dual specificity mitogen-activated protein kinase kinase 4 (Kinase)
Gene: MAP2K4
UniProt: P45985 (MP2K4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.15
Assay: Binding constant for MEK4 kinase domain
Drug: sunitinib
Target: Dual specificity mitogen-activated protein kinase kinase 6 (Kinase)
Gene: MAP2K6
UniProt: P52564 (MP2K6_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.28
Assay: Binding constant for MEK6 kinase domain
Drug: sunitinib
Target: Tyrosine-protein kinase Mer (Kinase)
Gene: MERTK
UniProt: Q12866 (MERTK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.59
Assay: Binding constant for MERTK kinase domain
Drug: sunitinib
Target: Calcium/calmodulin-dependent protein kinase type IV (Kinase)
Gene: CAMK4
UniProt: Q16566 (KCC4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.05
Assay: Binding constant for CAMK4 kinase domain
Drug: sunitinib
Target: Myosin light chain kinase, smooth muscle (Kinase)
Gene: Mylk
UniProt: P11799 (MYLK_CHICK)
Organism: Gallus gallus
Activity: Kd = 7.64
Assay: Binding constant for MLCK kinase domain
Drug: sunitinib
Target: Mitogen-activated protein kinase kinase kinase 9 (Kinase)
Gene: MAP3K9
UniProt: P80192 (M3K9_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.47
Assay: Binding constant for MLK1 kinase domain
Drug: sunitinib
Target: Mitogen-activated protein kinase kinase kinase 11 (Kinase)
Gene: MAP3K11
UniProt: Q16584 (M3K11_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.89
Assay: Binding constant for MLK3 kinase domain
Drug: sunitinib
Target: Serine/threonine-protein kinase 24 (Kinase)
Gene: STK24
UniProt: Q9Y6E0 (STK24_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.2
Assay: Binding constant for MST3 kinase domain
Drug: sunitinib
Target: Muscle, skeletal receptor tyrosine-protein kinase (Kinase)
Gene: MUSK
UniProt: O15146 (MUSK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.31
Assay: Binding constant for MUSK kinase domain
Drug: sunitinib
Target: Citron Rho-interacting kinase (Kinase)
Gene: CIT
UniProt: O14578 (CTRO_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.41
Assay: Binding constant for CIT kinase domain
Drug: sunitinib
Target: Casein kinase I isoform gamma-1 (Kinase)
Gene: CSNK1G1
UniProt: Q9HCP0 (KC1G1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.03
Assay: Binding constant for CSNK1G1 kinase domain
Drug: sunitinib
Target: Death-associated protein kinase 1 (Kinase)
Gene: DAPK1
UniProt: P53355 (DAPK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.92
Assay: Binding constant for DAPK1 kinase domain