AIM-Harvard/TrialPanorama-filtered huggingface dataset:
Drug: asenapine
Target: D(1A) dopamine receptor (GPCR)
Gene: DRD1
UniProt: P21728 (DRD1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.7
Drug: asenapine
Target: D(2) dopamine receptor (GPCR)
Gene: DRD2
UniProt: P14416 (DRD2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.75
Action type: ANTAGONIST
Drug: asenapine
Target: Alpha-2A adrenergic receptor (GPCR)
Gene: ADRA2A
UniProt: P08913 (ADA2A_HUMAN)
Organism: Homo sapiens
Activity: Ki  8.187
Drug: asenapine
Target: 5-hydroxytryptamine receptor 1A (GPCR)
Gene: HTR1A
UniProt: P08908 (5HT1A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.97
Drug: asenapine
Target: 5-hydroxytryptamine receptor 2A (GPCR)
Gene: HTR2A
UniProt: P28223 (5HT2A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 9.61
Action type: ANTAGONIST
Drug: asenapine
Target: 5-hydroxytryptamine receptor 2B (GPCR)
Gene: HTR2B
UniProt: P41595 (5HT2B_HUMAN)
Organism: Homo sapiens
Activity: Ki = 9.8
Drug: asenapine
Target: 5-hydroxytryptamine receptor 2C (GPCR)
Gene: HTR2C
UniProt: P28335 (5HT2C_HUMAN)
Organism: Homo sapiens
Activity: Ki = 9.93
Drug: asenapine
Target: 5-hydroxytryptamine receptor 6 (GPCR)
Gene: HTR6
UniProt: P50406 (5HT6R_HUMAN)
Organism: Homo sapiens
Activity: Ki = 9.22
Drug: asenapine
Target: 5-hydroxytryptamine receptor 7 (GPCR)
Gene: HTR7
UniProt: P34969 (5HT7R_HUMAN)
Organism: Homo sapiens
Activity: Ki = 9.47
Drug: asenapine
Target: Alpha-1A adrenergic receptor (GPCR)
Gene: ADRA1A
UniProt: P35348 (ADA1A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.92
Drug: asenapine
Target: Alpha-2B adrenergic receptor (GPCR)
Gene: ADRA2B
UniProt: P18089 (ADA2B_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.73
Drug: asenapine
Target: D(3) dopamine receptor (GPCR)
Gene: DRD3
UniProt: P35462 (DRD3_HUMAN)
Organism: Homo sapiens
Activity: Ki = 9.06
Drug: asenapine
Target: D(1B) dopamine receptor (GPCR)
Gene: DRD5
UniProt: P21918 (DRD5_HUMAN)
Organism: Homo sapiens
Activity: Ki  7.644
Drug: asenapine
Target: Histamine H1 receptor (GPCR)
Gene: HRH1
UniProt: P35367 (HRH1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 9
Drug: asenapine
Target: Histamine H2 receptor (GPCR)
Gene: HRH2
UniProt: P25021 (HRH2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 8.21
Drug: asenapine
Target: Muscarinic acetylcholine receptor M1 (GPCR)
Gene: CHRM1
UniProt: P11229 (ACM1_HUMAN)
Organism: Homo sapiens
Activity: Ki  6.107
Drug: asenapine
Target: Muscarinic acetylcholine receptor M2 (GPCR)
Gene: CHRM2
UniProt: P08172 (ACM2_HUMAN)
Organism: Homo sapiens
Activity: Ki  6.039
Drug: asenapine
Target: Muscarinic acetylcholine receptor M3 (GPCR)
Gene: CHRM3
UniProt: P20309 (ACM3_HUMAN)
Organism: Homo sapiens
Activity: Ki  5.491
Drug: asenapine
Target: Muscarinic acetylcholine receptor M5 (GPCR)
Gene: CHRM5
UniProt: P08912 (ACM5_HUMAN)
Organism: Homo sapiens
Activity: Ki  6.565
Drug: asenapine
Target: 5-hydroxytryptamine receptor 1B (GPCR)
Gene: HTR1B
UniProt: P28222 (5HT1B_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.4
Drug: asenapine
Target: 5-hydroxytryptamine receptor 1D (GPCR)
Gene: HTR1D
UniProt: P28221 (5HT1D_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.4
Action type: AGONIST
Drug: asenapine
Target: Alpha-2C adrenergic receptor (GPCR)
Gene: ADRA2C
UniProt: P18825 (ADA2C_HUMAN)
Organism: Homo sapiens
Activity: Ki  7.886
Drug: asenapine
Target: Sodium-dependent dopamine transporter (Transporter)
Gene: SLC6A3
UniProt: Q01959 (SC6A3_HUMAN)
Organism: Homo sapiens
Activity: Ki  5.504
Drug: asenapine
Target: D(4) dopamine receptor (GPCR)
Gene: DRD4
UniProt: P21917 (DRD4_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.71
Drug: asenapine
Target: 5-hydroxytryptamine receptor 3A (Ion channel)
Gene: HTR3A
UniProt: P46098 (5HT3A_HUMAN)
Organism: Homo sapiens
Activity: Ki  6.349
Drug: asenapine
Target: Alpha-1B adrenergic receptor (GPCR)
Gene: ADRA1B
UniProt: P35368 (ADA1B_HUMAN)
Organism: Homo sapiens
Activity: Ki  8.409
Drug: asenapine
Target: 5-hydroxytryptamine receptor 5A (GPCR)
Gene: HTR5A
UniProt: P47898 (5HT5A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.6
Drug: asenapine
Target: 5-hydroxytryptamine receptor 1E (GPCR)
Gene: HTR1E
UniProt: P28566 (5HT1E_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8
Action type: AGONIST
Drug: pralatrexate
Target: Dihydrofolate reductase (Enzyme)
Gene: DHFR
UniProt: P00374 (DYR_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.35
Action type: INHIBITOR
Drug: pralatrexate
Target: Proton-coupled folate transporter (Transporter)
Gene: SLC46A1
UniProt: Q96NT5 (PCFT_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7.24
Assay: Binding affinity to human PCFT expressed in Chinese hamster R2/PCFT4 cells assessed as antiproliferative activity measured as reduction in cell viability after 96 hrs by Cell-Titer Blue assay
Drug: pralatrexate
Target: Folate transporter 1 (Transporter)
Gene: SLC19A1
UniProt: P41440 (S19A1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 9.16
Assay: Binding affinity to human RFC expressed in Chinese hamster PC43-10 cells assessed as antiproliferative activity measured as reduction in cell viability after 96 hrs by Cell-Titer Blue assay
Drug: pralatrexate
Target: Folate receptor alpha (Membrane receptor)
Gene: FOLR1
UniProt: P15328 (FOLR1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.78
Assay: Binding affinity to human FR-alpha receptor expressed in Chinese hamster RT16 cells assessed as antiproliferative activity measured as reduction in cell viability after 96 hrs by Cell-Titer Blue assay
Drug: pazopanib
Target: Tyrosine-protein kinase JAK3 (Kinase)
Gene: JAK3
UniProt: P52333 (JAK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.16
Assay: Binding constant for JAK3(Kin.Dom.2/JH1 - catalytic) kinase domain
Drug: pazopanib
Target: Acetylcholinesterase (Enzyme)
Gene: ACHE
UniProt: P22303 (ACES_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.03
Assay: Inhibition of AChE (unknown origin)
Drug: pazopanib
Target: Platelet-derived growth factor receptor beta (Kinase)
Gene: PDGFRB
UniProt: P09619 (PGFRB_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.7
Action type: INHIBITOR
Assay: Binding constant for PDGFRB kinase domain
Drug: pazopanib
Target: Tyrosine-protein kinase ABL1 (Kinase)
Gene: ABL1
UniProt: P00519 (ABL1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.42
Assay: Binding constant for ABL1(H396P)-non phosphorylated kinase domain
Drug: pazopanib
Target: Mast/stem cell growth factor receptor Kit (Kinase)
Gene: KIT
UniProt: P10721 (KIT_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.74
Action type: INHIBITOR
Assay: Binding constant for KIT(L576P) kinase domain
Drug: pazopanib
Target: Proto-oncogene tyrosine-protein kinase Src (Kinase)
Gene: SRC
UniProt: P12931 (SRC_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.55
Assay: Binding constant for SRC kinase domain
Drug: pazopanib
Target: Tyrosine-protein kinase Lck (Kinase)
Gene: LCK
UniProt: P06239 (LCK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.92
Action type: INHIBITOR
Assay: Binding constant for LCK kinase domain
Drug: pazopanib
Target: Tyrosine-protein kinase Yes (Kinase)
Gene: YES1
UniProt: P07947 (YES_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.3
Assay: Binding constant for YES kinase domain
Drug: pazopanib
Target: Tyrosine-protein kinase Fyn (Kinase)
Gene: FYN
UniProt: P06241 (FYN_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.57
Assay: Binding constant for FYN kinase domain
Drug: pazopanib
Target: RAF proto-oncogene serine/threonine-protein kinase (Kinase)
Gene: RAF1
UniProt: P04049 (RAF1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.05
Assay: Binding constant for RAF1 kinase domain
Drug: pazopanib
Target: Serine/threonine-protein kinase B-raf (Kinase)
Gene: BRAF
UniProt: P15056 (BRAF_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.37
Assay: Binding constant for BRAF(V600E) kinase domain
Drug: pazopanib
Target: Receptor-type tyrosine-protein kinase FLT3 (Kinase)
Gene: FLT3
UniProt: P36888 (FLT3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.13
Assay: Binding constant for FLT3(K663Q) kinase domain
Drug: pazopanib
Target: Proto-oncogene tyrosine-protein kinase receptor Ret (Kinase)
Gene: RET
UniProt: P07949 (RET_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.57
Assay: Binding constant for RET(M918T) kinase domain
Drug: pazopanib
Target: Vascular endothelial growth factor receptor 1 (Kinase)
Gene: FLT1
UniProt: P17948 (VGFR1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.85
Action type: INHIBITOR
Assay: Binding constant for FLT1 kinase domain
Drug: pazopanib
Target: Vascular endothelial growth factor receptor 2 (Kinase)
Gene: KDR
UniProt: P35968 (VGFR2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.85
Action type: INHIBITOR
Assay: Binding constant for VEGFR2 kinase domain
Drug: pazopanib
Target: Vascular endothelial growth factor receptor 3 (Kinase)
Gene: FLT4
UniProt: P35916 (VGFR3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.57
Action type: INHIBITOR
Assay: Binding constant for FLT4 kinase domain
Drug: pazopanib
Target: Macrophage colony-stimulating factor 1 receptor (Kinase)
Gene: CSF1R
UniProt: P07333 (CSF1R_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.1
Action type: INHIBITOR
Assay: Binding constant for CSF1R kinase domain
Drug: pazopanib
Target: Platelet-derived growth factor receptor alpha (Kinase)
Gene: PDGFRA
UniProt: P16234 (PGFRA_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.31
Action type: INHIBITOR
Assay: Binding constant for PDGFRA kinase domain
Drug: pazopanib
Target: Calcium/calmodulin-dependent protein kinase type 1 (Kinase)
Gene: CAMK1
UniProt: Q14012 (KCC1A_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.68
Assay: Binding constant for full-length CAMK1
Drug: pazopanib
Target: Mitogen-activated protein kinase 8 (Kinase)
Gene: MAPK8
UniProt: P45983 (MK08_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.7
Assay: Binding constant for JNK1 kinase domain
Drug: pazopanib
Target: Fibroblast growth factor receptor 3 (Kinase)
Gene: FGFR3
UniProt: P22607 (FGFR3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.21
Action type: INHIBITOR
Assay: Binding constant for FGFR3(G697C) kinase domain
Drug: pazopanib
Target: Tyrosine-protein kinase HCK (Kinase)
Gene: HCK
UniProt: P08631 (HCK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.24
Assay: Binding constant for HCK kinase domain
Drug: pazopanib
Target: Mitogen-activated protein kinase 10 (Kinase)
Gene: MAPK10
UniProt: P53779 (MK10_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.72
Assay: Binding constant for JNK3 kinase domain
Drug: pazopanib
Target: Tyrosine-protein kinase JAK2 (Kinase)
Gene: JAK2
UniProt: O60674 (JAK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.77
Assay: Binding constant for JAK2(JH1domain-catalytic) kinase domain
Drug: pazopanib
Target: Tyrosine-protein kinase SYK (Kinase)
Gene: SYK
UniProt: P43405 (KSYK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.33
Assay: Binding constant for SYK kinase domain
Drug: pazopanib
Target: Myosin light chain kinase 2, skeletal/cardiac muscle (Kinase)
Gene: MYLK2
UniProt: Q9H1R3 (MYLK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.7
Assay: Binding constant for MYLK2 kinase domain
Drug: pazopanib
Target: Angiopoietin-1 receptor (Kinase)
Gene: TEK
UniProt: Q02763 (TIE2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.48
Assay: Binding constant for TIE2 kinase domain
Drug: pazopanib
Target: AP2-associated protein kinase 1 (Kinase)
Gene: AAK1
UniProt: Q2M2I8 (AAK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.54
Assay: Binding constant for AAK1 kinase domain
Drug: pazopanib
Target: Hepatocyte growth factor receptor (Kinase)
Gene: MET
UniProt: P08581 (MET_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.7
Assay: Binding constant for MET kinase domain
Drug: pazopanib
Target: Tyrosine-protein kinase Lyn (Kinase)
Gene: LYN
UniProt: P07948 (LYN_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.05
Assay: Binding constant for LYN kinase domain
Drug: pazopanib
Target: Serine/threonine-protein kinase Nek2 (Kinase)
Gene: NEK2
UniProt: P51955 (NEK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.01
Assay: Binding constant for NEK2 kinase domain
Drug: pazopanib
Target: LIM domain kinase 1 (Kinase)
Gene: LIMK1
UniProt: P53667 (LIMK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.14
Assay: Binding constant for full-length LIMK1
Drug: pazopanib
Target: Fibroblast growth factor receptor 1 (Kinase)
Gene: FGFR1
UniProt: P11362 (FGFR1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6
Action type: INHIBITOR
Assay: Binding constant for FGFR1 kinase domain
Drug: pazopanib
Target: Serine/threonine-protein kinase 10 (Kinase)
Gene: STK10
UniProt: O94804 (STK10_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.08
Assay: Binding constant for LOK kinase domain
Drug: pazopanib
Target: Tyrosine-protein kinase Fer (Kinase)
Gene: FER
UniProt: P16591 (FER_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.57
Assay: Binding constant for FER kinase domain
Drug: pazopanib
Target: Serine/threonine-protein kinase PLK4 (Kinase)
Gene: PLK4
UniProt: O00444 (PLK4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.54
Assay: Binding constant for PLK4 kinase domain
Drug: pazopanib
Target: Aurora kinase C (Kinase)
Gene: AURKC
UniProt: Q9UQB9 (AURKC_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.12
Assay: Binding constant for full-length AURKC
Drug: pazopanib
Target: Serine/threonine-protein kinase 16 (Kinase)
Gene: STK16
UniProt: O75716 (STK16_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.44
Assay: Binding constant for STK16 kinase domain
Drug: pazopanib
Target: Dual specificity protein kinase TTK (Kinase)
Gene: TTK
UniProt: P33981 (TTK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.82
Assay: Binding constant for TTK kinase domain
Drug: pazopanib
Target: Abelson tyrosine-protein kinase 2 (Kinase)
Gene: ABL2
UniProt: P42684 (ABL2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.52
Assay: Binding constant for ABL2 kinase domain
Drug: pazopanib
Target: Fibroblast growth factor receptor 2 (Kinase)
Gene: FGFR2
UniProt: P21802 (FGFR2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.68
Assay: Binding constant for FGFR2 kinase domain
Drug: pazopanib
Target: TRAF2 and NCK-interacting protein kinase (Kinase)
Gene: TNIK
UniProt: Q9UKE5 (TNIK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.51
Assay: Binding constant for TNIK kinase domain
Drug: pazopanib
Target: Tyrosine-protein kinase Fgr (Kinase)
Gene: FGR
UniProt: P09769 (FGR_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.8
Assay: Binding constant for FGR kinase domain
Drug: pazopanib
Target: Aurora kinase A (Kinase)
Gene: AURKA
UniProt: O14965 (AURKA_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.15
Assay: Binding constant for AURKA kinase domain
Drug: pazopanib
Target: ALK tyrosine kinase receptor (Kinase)
Gene: ALK
UniProt: Q9UM73 (ALK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.66
Assay: Binding constant for ALK kinase domain
Drug: pazopanib
Target: Serine/threonine-protein kinase 36 (Kinase)
Gene: STK36
UniProt: Q9NRP7 (STK36_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.33
Assay: Binding constant for STK36 kinase domain
Drug: pazopanib
Target: BMP-2-inducible protein kinase (Kinase)
Gene: BMP2K
UniProt: Q9NSY1 (BMP2K_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.06
Assay: Binding constant for BIKE kinase domain
Drug: pazopanib
Target: Tyrosine-protein kinase FRK (Kinase)
Gene: FRK
UniProt: P42685 (FRK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.12
Assay: Binding constant for FRK kinase domain
Drug: pazopanib
Target: Mitogen-activated protein kinase kinase kinase kinase 5 (Kinase)
Gene: MAP4K5
UniProt: Q9Y4K4 (M4K5_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.52
Assay: Binding constant for MAP4K5 kinase domain
Drug: pazopanib
Target: Cyclin-G-associated kinase (Kinase)
Gene: GAK
UniProt: O14976 (GAK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.7
Assay: Binding constant for GAK kinase domain
Drug: pazopanib
Target: Receptor-interacting serine/threonine-protein kinase 2 (Kinase)
Gene: RIPK2
UniProt: O43353 (RIPK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.24
Assay: Binding constant for RIPK2 kinase domain
Drug: pazopanib
Target: Cyclin-dependent kinase 16 (Kinase)
Gene: CDK16
UniProt: Q00536 (CDK16_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.92
Assay: Binding constant for PCTK1 kinase domain
Drug: pazopanib
Target: STE20-like serine/threonine-protein kinase (Kinase)
Gene: SLK
UniProt: Q9H2G2 (SLK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.62
Assay: Binding constant for SLK kinase domain
Drug: pazopanib
Target: MAP/microtubule affinity-regulating kinase 3 (Kinase)
Gene: MARK3
UniProt: P27448 (MARK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.4
Assay: Binding constant for full-length MARK3
Drug: pazopanib
Target: Calcium/calmodulin-dependent protein kinase type 1G (Kinase)
Gene: CAMK1G
UniProt: Q96NX5 (KCC1G_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.43
Assay: Binding constant for CAMK1G kinase domain
Drug: pazopanib
Target: Epithelial discoidin domain-containing receptor 1 (Kinase)
Gene: DDR1
UniProt: Q08345 (DDR1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.24
Assay: Binding constant for DDR1 kinase domain
Drug: pazopanib
Target: TGF-beta receptor type-2 (Kinase)
Gene: TGFBR2
UniProt: P37173 (TGFR2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.52
Assay: Binding constant for TGFBR2 kinase domain
Drug: pazopanib
Target: Tyrosine-protein kinase ITK/TSK (Kinase)
Gene: ITK
UniProt: Q08881 (ITK_HUMAN)
Organism: Homo sapiens
Action type: INHIBITOR
Assay: Mechanism of Action; CHEMBL2959; SINGLE PROTEIN
Drug: pazopanib
Target: Protein-tyrosine kinase 6 (Kinase)
Gene: PTK6
UniProt: Q13882 (PTK6_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.64
Assay: Binding constant for PTK6 kinase domain
Drug: pazopanib
Target: Non-receptor tyrosine-protein kinase TNK1 (Kinase)
Gene: TNK1
UniProt: Q13470 (TNK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.01
Assay: Binding constant for full-length TNK1
Drug: pazopanib
Target: Non-receptor tyrosine-protein kinase TYK2 (Kinase)
Gene: TYK2
UniProt: P29597 (TYK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.47
Assay: Binding constant for TYK2(JH1domain-catalytic) kinase domain
Drug: pazopanib
Target: Tyrosine-protein kinase receptor Tie-1 (Kinase)
Gene: TIE1
UniProt: P35590 (TIE1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.15
Assay: Binding constant for TIE1 kinase domain
Drug: pazopanib
Target: Tyrosine-protein kinase TXK (Kinase)
Gene: TXK
UniProt: P42681 (TXK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.59
Assay: Binding constant for TXK kinase domain
Drug: pazopanib
Target: LIM domain kinase 2 (Kinase)
Gene: LIMK2
UniProt: P53671 (LIMK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.41
Assay: Binding constant for full-length LIMK2
Drug: pazopanib
Target: Serine/threonine-protein kinase NLK (Kinase)
Gene: NLK
UniProt: Q9UBE8 (NLK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.36
Assay: Binding constant for full-length NLK
Drug: pazopanib
Target: Interleukin-1 receptor-associated kinase 3 (Kinase)
Gene: IRAK3
UniProt: Q9Y616 (IRAK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.1
Assay: Binding constant for IRAK3 kinase domain
Drug: pazopanib
Target: Serine/threonine-protein kinase SIK2 (Kinase)
Gene: SIK2
UniProt: Q9H0K1 (SIK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.14
Assay: Binding constant for full-length SNF1LK2
Drug: pazopanib
Target: Activin receptor type-2B (Kinase)
Gene: ACVR2B
UniProt: Q13705 (AVR2B_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.62
Assay: Binding constant for ACVR2B kinase domain
Drug: pazopanib
Target: Discoidin domain-containing receptor 2 (Kinase)
Gene: DDR2
UniProt: Q16832 (DDR2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.01
Assay: Binding constant for DDR2 kinase domain
Drug: pazopanib
Target: Leukocyte tyrosine kinase receptor (Kinase)
Gene: LTK
UniProt: P29376 (LTK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.17
Assay: Binding constant for LTK kinase domain
Drug: pazopanib
Target: Mitogen-activated protein kinase kinase kinase kinase 1 (Kinase)
Gene: MAP4K1
UniProt: Q92918 (M4K1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.12
Assay: Binding constant for MAP4K1 kinase domain
Drug: pazopanib
Target: Mitogen-activated protein kinase kinase kinase kinase 3 (Kinase)
Gene: MAP4K3
UniProt: Q8IVH8 (M4K3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.8
Assay: Binding constant for MAP4K3 kinase domain
Drug: pazopanib
Target: Tyrosine-protein kinase Blk (Kinase)
Gene: BLK
UniProt: P51451 (BLK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.59
Assay: Binding constant for BLK kinase domain
Drug: pazopanib
Target: Mitogen-activated protein kinase kinase kinase kinase 4 (Kinase)
Gene: MAP4K4
UniProt: O95819 (M4K4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.66
Assay: Binding constant for MAP4K4 kinase domain
Drug: pazopanib
Target: Dual specificity mitogen-activated protein kinase kinase 4 (Kinase)
Gene: MAP2K4
UniProt: P45985 (MP2K4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.23
Assay: Binding constant for MEK4 kinase domain
Drug: pazopanib
Target: Dual specificity mitogen-activated protein kinase kinase 6 (Kinase)
Gene: MAP2K6
UniProt: P52564 (MP2K6_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.39
Assay: Binding constant for MEK6 kinase domain
Drug: pazopanib
Target: Tyrosine-protein kinase Mer (Kinase)
Gene: MERTK
UniProt: Q12866 (MERTK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.48
Assay: Binding constant for MERTK kinase domain
Drug: pazopanib
Target: Cyclin-dependent kinase 11B (Kinase)
Gene: CDK11B
UniProt: P21127 (CD11B_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.68
Assay: Binding constant for CDC2L1 kinase domain
Drug: pazopanib
Target: Cyclin-dependent kinase 11A (Kinase)
Gene: CDK11A
UniProt: Q9UQ88 (CD11A_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.89
Assay: Binding constant for CDC2L2 kinase domain
Drug: pazopanib
Target: Mitogen-activated protein kinase kinase kinase 9 (Kinase)
Gene: MAP3K9
UniProt: P80192 (M3K9_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.54
Assay: Binding constant for MLK1 kinase domain
Drug: pazopanib
Target: Mitogen-activated protein kinase kinase kinase 10 (Kinase)
Gene: MAP3K10
UniProt: Q02779 (M3K10_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.68
Assay: Binding constant for MLK2 kinase domain
Drug: pazopanib
Target: Mitogen-activated protein kinase kinase kinase 11 (Kinase)
Gene: MAP3K11
UniProt: Q16584 (M3K11_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.13
Assay: Binding constant for MLK3 kinase domain
Drug: pazopanib
Target: Serine/threonine-protein kinase Nek5 (Kinase)
Gene: NEK5
UniProt: Q6P3R8 (NEK5_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.14
Assay: Binding constant for NEK5 kinase domain
Drug: pazopanib
Target: Serine/threonine-protein kinase SIK1 (Kinase)
Gene: SIK1
UniProt: P57059 (SIK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.66
Assay: Binding constant for SNF1LK kinase domain
Drug: pazopanib
Target: Tyrosine-protein kinase Srms (Kinase)
Gene: SRMS
UniProt: Q9H3Y6 (SRMS_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.6
Assay: Binding constant for SRMS kinase domain
Drug: pazopanib
Target: Interferon-induced, double-stranded RNA-activated protein kinase (Kinase)
Gene: EIF2AK2
UniProt: P19525 (E2AK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.72
Assay: Binding constant for PRKR kinase domain
Drug: pazopanib
Target: Receptor-interacting serine/threonine-protein kinase 1 (Kinase)
Gene: RIPK1
UniProt: Q13546 (RIPK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.59
Assay: Binding constant for RIPK1 kinase domain
Drug: pazopanib
Target: Tyrosine-protein kinase Fes/Fps (Kinase)
Gene: FES
UniProt: P07332 (FES_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.85
Assay: Binding constant for FES kinase domain
Drug: pazopanib
Target: Fibroblast growth factor receptor 4 (Kinase)
Gene: FGFR4
UniProt: P22455 (FGFR4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.55
Assay: Binding constant for FGFR4 kinase domain
Drug: pazopanib
Target: Proto-oncogene tyrosine-protein kinase ROS (Kinase)
Gene: ROS1
UniProt: P08922 (ROS1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.04
Assay: Binding constant for ROS1 kinase domain
Drug: pazopanib
Target: Mitogen-activated protein kinase kinase kinase kinase 2 (Kinase)
Gene: MAP4K2
UniProt: Q12851 (M4K2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.57
Assay: Binding constant for MAP4K2 kinase domain
Drug: pazopanib
Target: Ephrin type-B receptor 6 (Kinase)
Gene: EPHB6
UniProt: O15197 (EPHB6_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.09
Assay: Binding constant for EPHB6 kinase domain