AIM-Harvard/TrialPanorama-filtered huggingface dataset:
Drug: fedratinib
Target: Hepatocyte growth factor receptor (Kinase)
Gene: MET
UniProt: P08581 (MET_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.36
Assay: Binding constant for MET(M1250T) kinase domain
Drug: fedratinib
Target: Tyrosine-protein kinase Lyn (Kinase)
Gene: LYN
UniProt: P07948 (LYN_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.3
Assay: Binding constant for LYN kinase domain
Drug: fedratinib
Target: Cytoplasmic tyrosine-protein kinase BMX (Kinase)
Gene: BMX
UniProt: P51813 (BMX_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.92
Assay: Binding constant for BMX kinase domain
Drug: fedratinib
Target: Serine/threonine-protein kinase Nek2 (Kinase)
Gene: NEK2
UniProt: P51955 (NEK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.77
Assay: Binding constant for NEK2 kinase domain
Drug: fedratinib
Target: LIM domain kinase 1 (Kinase)
Gene: LIMK1
UniProt: P53667 (LIMK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.03
Assay: Binding constant for LIMK1 kinase domain
Drug: fedratinib
Target: Ribosomal protein S6 kinase alpha-2 (Kinase)
Gene: RPS6KA2
UniProt: Q15349 (KS6A2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.64
Assay: Binding constant for RSK3(Kin.Dom.2-C-terminal) kinase domain
Drug: fedratinib
Target: 5'-AMP-activated protein kinase catalytic subunit alpha-1 (Kinase)
Gene: PRKAA1
UniProt: Q13131 (AAPK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.62
Assay: Binding constant for AMPK-alpha1 kinase domain
Drug: fedratinib
Target: Calcium/calmodulin-dependent protein kinase type II subunit beta (Kinase)
Gene: CAMK2B
UniProt: Q13554 (KCC2B_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.17
Assay: Binding constant for CAMK2B kinase domain
Drug: fedratinib
Target: Fibroblast growth factor receptor 1 (Kinase)
Gene: FGFR1
UniProt: P11362 (FGFR1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.55
Assay: Binding constant for FGFR1 kinase domain
Drug: fedratinib
Target: Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform (Kinase)
Gene: PHKG1
UniProt: Q16816 (PHKG1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.48
Assay: Binding constant for PHKG1 kinase domain
Drug: fedratinib
Target: Calcium/calmodulin-dependent protein kinase type II subunit alpha (Kinase)
Gene: CAMK2A
UniProt: Q9UQM7 (KCC2A_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.52
Assay: Binding constant for CAMK2A kinase domain
Drug: fedratinib
Target: Serine/threonine-protein kinase 17B (Kinase)
Gene: STK17B
UniProt: O94768 (ST17B_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.35
Assay: Binding constant for DRAK2 kinase domain
Drug: fedratinib
Target: Serine/threonine-protein kinase 10 (Kinase)
Gene: STK10
UniProt: O94804 (STK10_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.54
Assay: Binding constant for LOK kinase domain
Drug: fedratinib
Target: Tyrosine-protein kinase Fer (Kinase)
Gene: FER
UniProt: P16591 (FER_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.96
Assay: Binding constant for FER kinase domain
Drug: fedratinib
Target: Protein kinase C epsilon type (Kinase)
Gene: PRKCE
UniProt: Q02156 (KPCE_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.09
Assay: Binding constant for PRKCE kinase domain
Drug: fedratinib
Target: Serine/threonine-protein kinase PLK4 (Kinase)
Gene: PLK4
UniProt: O00444 (PLK4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.02
Assay: Binding constant for PLK4 kinase domain
Drug: fedratinib
Target: Aurora kinase C (Kinase)
Gene: AURKC
UniProt: Q9UQB9 (AURKC_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.46
Assay: Binding constant for AURKC kinase domain
Drug: fedratinib
Target: Serine/threonine-protein kinase 16 (Kinase)
Gene: STK16
UniProt: O75716 (STK16_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.18
Assay: Binding constant for STK16 kinase domain
Drug: fedratinib
Target: Dual specificity protein kinase TTK (Kinase)
Gene: TTK
UniProt: P33981 (TTK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.35
Assay: Binding constant for TTK kinase domain
Drug: fedratinib
Target: Abelson tyrosine-protein kinase 2 (Kinase)
Gene: ABL2
UniProt: P42684 (ABL2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.24
Assay: Binding constant for ABL2 kinase domain
Drug: fedratinib
Target: Ephrin type-A receptor 4 (Kinase)
Gene: EPHA4
UniProt: P54764 (EPHA4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.4
Assay: Binding constant for EPHA4 kinase domain
Drug: fedratinib
Target: Fibroblast growth factor receptor 2 (Kinase)
Gene: FGFR2
UniProt: P21802 (FGFR2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.33
Assay: Binding constant for FGFR2 kinase domain
Drug: fedratinib
Target: Serine/threonine-protein kinase N1 (Kinase)
Gene: PKN1
UniProt: Q16512 (PKN1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.96
Assay: Binding constant for PKN1 kinase domain
Drug: fedratinib
Target: Serine/threonine-protein kinase 17A (Kinase)
Gene: STK17A
UniProt: Q9UEE5 (ST17A_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.21
Assay: Binding constant for DRAK1 kinase domain
Drug: fedratinib
Target: Ephrin type-A receptor 6 (Kinase)
Gene: EPHA6
UniProt: Q9UF33 (EPHA6_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.41
Assay: Binding constant for EPHA6 kinase domain
Drug: fedratinib
Target: Tyrosine-protein kinase Fgr (Kinase)
Gene: FGR
UniProt: P09769 (FGR_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.09
Assay: Binding constant for FGR kinase domain
Drug: fedratinib
Target: Aurora kinase A (Kinase)
Gene: AURKA
UniProt: O14965 (AURKA_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.36
Assay: Binding constant for AURKA kinase domain
Drug: fedratinib
Target: ALK tyrosine kinase receptor (Kinase)
Gene: ALK
UniProt: Q9UM73 (ALK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.19
Assay: Binding constant for ALK kinase domain
Drug: fedratinib
Target: Serine/threonine-protein kinase 36 (Kinase)
Gene: STK36
UniProt: Q9NRP7 (STK36_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.06
Assay: Binding constant for STK36 kinase domain
Drug: fedratinib
Target: Ephrin type-A receptor 3 (Kinase)
Gene: EPHA3
UniProt: P29320 (EPHA3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.15
Assay: Binding constant for EPHA3 kinase domain
Drug: fedratinib
Target: BMP-2-inducible protein kinase (Kinase)
Gene: BMP2K
UniProt: Q9NSY1 (BMP2K_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.5
Assay: Binding constant for BIKE kinase domain
Drug: fedratinib
Target: Tyrosine-protein kinase FRK (Kinase)
Gene: FRK
UniProt: P42685 (FRK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.7
Assay: Binding constant for FRK kinase domain
Drug: fedratinib
Target: Dual specificity protein kinase CLK1 (Kinase)
Gene: CLK1
UniProt: P49759 (CLK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.6
Assay: Binding constant for CLK1 kinase domain
Drug: fedratinib
Target: Dual specificity protein kinase CLK2 (Kinase)
Gene: CLK2
UniProt: P49760 (CLK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.64
Assay: Binding constant for CLK2 kinase domain
Drug: fedratinib
Target: Mitogen-activated protein kinase kinase kinase 4 (Kinase)
Gene: MAP3K4
UniProt: Q9Y6R4 (M3K4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.39
Assay: Binding constant for MAP3K4 kinase domain
Drug: fedratinib
Target: Cyclin-G-associated kinase (Kinase)
Gene: GAK
UniProt: O14976 (GAK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.96
Assay: Binding constant for GAK kinase domain
Drug: fedratinib
Target: Receptor-interacting serine/threonine-protein kinase 2 (Kinase)
Gene: RIPK2
UniProt: O43353 (RIPK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.21
Assay: Binding constant for RIPK2 kinase domain
Drug: fedratinib
Target: Ephrin type-B receptor 1 (Kinase)
Gene: EPHB1
UniProt: P54762 (EPHB1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.77
Assay: Binding constant for EPHB1 kinase domain
Drug: fedratinib
Target: Calcium/calmodulin-dependent protein kinase type 1D (Kinase)
Gene: CAMK1D
UniProt: Q8IU85 (KCC1D_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.34
Assay: Binding constant for CAMK1D kinase domain
Drug: fedratinib
Target: Cyclin-dependent kinase 16 (Kinase)
Gene: CDK16
UniProt: Q00536 (CDK16_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.51
Assay: Binding constant for PCTK1 kinase domain
Drug: fedratinib
Target: Activated CDC42 kinase 1 (Kinase)
Gene: TNK2
UniProt: Q07912 (ACK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.19
Assay: Binding constant for TNK2 kinase domain
Drug: fedratinib
Target: Ephrin type-A receptor 7 (Kinase)
Gene: EPHA7
UniProt: Q15375 (EPHA7_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.19
Assay: Binding constant for EPHA7 kinase domain
Drug: fedratinib
Target: Ribosomal protein S6 kinase alpha-5 (Kinase)
Gene: RPS6KA5
UniProt: O75582 (KS6A5_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.66
Assay: Binding constant for RPS6KA5(Kin.Dom.2-C-terminal) kinase domain
Drug: fedratinib
Target: STE20-like serine/threonine-protein kinase (Kinase)
Gene: SLK
UniProt: Q9H2G2 (SLK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.17
Assay: Binding constant for SLK kinase domain
Drug: fedratinib
Target: Dual specificity protein kinase CLK4 (Kinase)
Gene: CLK4
UniProt: Q9HAZ1 (CLK4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.7
Assay: Binding constant for CLK4 kinase domain
Drug: fedratinib
Target: MAP kinase-interacting serine/threonine-protein kinase 2 (Kinase)
Gene: MKNK2
UniProt: Q9HBH9 (MKNK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.42
Assay: Binding constant for MKNK2 kinase domain
Drug: fedratinib
Target: Mitogen-activated protein kinase 9 (Kinase)
Gene: MAPK9
UniProt: P45984 (MK09_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.62
Assay: Binding constant for JNK2 kinase domain
Drug: fedratinib
Target: Calcium/calmodulin-dependent protein kinase kinase 2 (Kinase)
Gene: CAMKK2
UniProt: Q96RR4 (KKCC2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.4
Assay: Binding constant for CAMKK2 kinase domain
Drug: fedratinib
Target: MAP/microtubule affinity-regulating kinase 3 (Kinase)
Gene: MARK3
UniProt: P27448 (MARK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.52
Assay: Binding constant for MARK3 kinase domain
Drug: fedratinib
Target: Calcium/calmodulin-dependent protein kinase kinase 1 (Kinase)
Gene: CAMKK1
UniProt: Q8N5S9 (KKCC1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.75
Assay: Binding constant for CAMKK1 kinase domain
Drug: fedratinib
Target: Calcium/calmodulin-dependent protein kinase type 1G (Kinase)
Gene: CAMK1G
UniProt: Q96NX5 (KCC1G_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.5
Assay: Binding constant for CAMK1G kinase domain
Drug: fedratinib
Target: Epithelial discoidin domain-containing receptor 1 (Kinase)
Gene: DDR1
UniProt: Q08345 (DDR1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.72
Assay: Binding constant for DDR1 kinase domain
Drug: fedratinib
Target: Ephrin type-B receptor 4 (Kinase)
Gene: EPHB4
UniProt: P54760 (EPHB4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.68
Assay: Binding constant for EPHB4 kinase domain
Drug: fedratinib
Target: Testis-specific serine/threonine-protein kinase 1 (Kinase)
Gene: TSSK1B
UniProt: Q9BXA7 (TSSK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.89
Assay: Binding constant for TSSK1B kinase domain
Drug: fedratinib
Target: Activin receptor type-1B (Kinase)
Gene: ACVR1B
UniProt: P36896 (ACV1B_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.17
Assay: Binding constant for ACVR1B kinase domain
Drug: fedratinib
Target: Serine/threonine-protein kinase receptor R3 (Kinase)
Gene: ACVRL1
UniProt: P37023 (ACVL1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.62
Assay: Binding constant for ACVRL1 kinase domain
Drug: fedratinib
Target: Activin receptor type-1 (Kinase)
Gene: ACVR1
UniProt: Q04771 (ACVR1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.82
Assay: Binding constant for ACVR1 kinase domain
Drug: fedratinib
Target: Cyclin-dependent kinase 15 (Kinase)
Gene: CDK15
UniProt: Q96Q40 (CDK15_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.07
Assay: Binding constant for PFTAIRE2 kinase domain
Drug: fedratinib
Target: Inhibitor of nuclear factor kappa-B kinase subunit beta (Kinase)
Gene: IKBKB
UniProt: O14920 (IKKB_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.44
Assay: Binding constant for IKK-beta kinase domain
Drug: fedratinib
Target: TGF-beta receptor type-2 (Kinase)
Gene: TGFBR2
UniProt: P37173 (TGFR2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.96
Assay: Binding constant for TGFBR2 kinase domain
Drug: fedratinib
Target: Dual specificity mitogen-activated protein kinase kinase 1 (Kinase)
Gene: MAP2K1
UniProt: Q02750 (MP2K1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.29
Assay: Binding constant for MEK1 kinase domain
Drug: fedratinib
Target: Dual specificity mitogen-activated protein kinase kinase 2 (Kinase)
Gene: MAP2K2
UniProt: P36507 (MP2K2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.51
Assay: Binding constant for MEK2 kinase domain
Drug: fedratinib
Target: Tyrosine-protein kinase ITK/TSK (Kinase)
Gene: ITK
UniProt: Q08881 (ITK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.31
Assay: Binding constant for ITK kinase domain
Drug: fedratinib
Target: Tyrosine-protein kinase ZAP-70 (Kinase)
Gene: ZAP70
UniProt: P43403 (ZAP70_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.42
Assay: Binding constant for ZAP70 kinase domain
Drug: fedratinib
Target: Cyclin-dependent kinase 9 (Kinase)
Gene: CDK9
UniProt: P50750 (CDK9_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.06
Assay: Binding constant for CDK9 kinase domain
Drug: fedratinib
Target: Protein-tyrosine kinase 6 (Kinase)
Gene: PTK6
UniProt: Q13882 (PTK6_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.92
Assay: Binding constant for BRK kinase domain
Drug: fedratinib
Target: Tyrosine-protein kinase BTK (Kinase)
Gene: BTK
UniProt: Q06187 (BTK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.07
Assay: Binding constant for BTK kinase domain
Drug: fedratinib
Target: Tyrosine-protein kinase receptor UFO (Kinase)
Gene: AXL
UniProt: P30530 (UFO_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.8
Assay: Binding constant for AXL kinase domain
Drug: fedratinib
Target: BDNF/NT-3 growth factors receptor (Kinase)
Gene: NTRK2
UniProt: Q16620 (NTRK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.51
Assay: Binding constant for TRKB kinase domain
Drug: fedratinib
Target: Ephrin type-B receptor 2 (Kinase)
Gene: EPHB2
UniProt: P29323 (EPHB2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.41
Assay: Binding constant for EPHB2 kinase domain
Drug: fedratinib
Target: Cyclin-dependent kinase 7 (Kinase)
Gene: CDK7
UniProt: P50613 (CDK7_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.92
Assay: Binding constant for CDK7 kinase domain
Drug: fedratinib
Target: Ribosomal protein S6 kinase beta-1 (Kinase)
Gene: RPS6KB1
UniProt: P23443 (KS6B1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.7
Assay: Binding constant for S6K1 kinase domain
Drug: fedratinib
Target: Serine/threonine-protein kinase DCLK3 (Kinase)
Gene: DCLK3
UniProt: Q9C098 (DCLK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.89
Assay: Binding constant for DCAMKL3 kinase domain
Drug: fedratinib
Target: Ribosomal protein S6 kinase alpha-6 (Kinase)
Gene: RPS6KA6
UniProt: Q9UK32 (KS6A6_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.44
Assay: Binding constant for RSK4(Kin.Dom.2-C-terminal) kinase domain
Drug: fedratinib
Target: NUAK family SNF1-like kinase 2 (Kinase)
Gene: NUAK2
UniProt: Q9H093 (NUAK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.31
Assay: Binding constant for SNARK kinase domain
Drug: fedratinib
Target: Non-receptor tyrosine-protein kinase TNK1 (Kinase)
Gene: TNK1
UniProt: Q13470 (TNK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.44
Assay: Binding constant for TNK1 kinase domain
Drug: fedratinib
Target: Serine/threonine-protein kinase Chk1 (Kinase)
Gene: CHEK1
UniProt: O14757 (CHK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.42
Assay: Binding constant for CHEK1 kinase domain
Drug: fedratinib
Target: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Kinase)
Gene: PIK3CA
UniProt: P42336 (PK3CA_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.41
Assay: Binding constant for PIK3CA(H1047L) kinase domain
Drug: fedratinib
Target: Cyclin-dependent kinase 17 (Kinase)
Gene: CDK17
UniProt: Q00537 (CDK17_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.46
Assay: Binding constant for PCTK2 kinase domain
Drug: fedratinib
Target: Cyclin-dependent kinase 18 (Kinase)
Gene: CDK18
UniProt: Q07002 (CDK18_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.57
Assay: Binding constant for PCTK3 kinase domain
Drug: fedratinib
Target: Cyclin-dependent kinase 14 (Kinase)
Gene: CDK14
UniProt: O94921 (CDK14_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.58
Assay: Binding constant for PFTK1 kinase domain
Drug: fedratinib
Target: Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (Kinase)
Gene: PIP5K1A
UniProt: Q99755 (PI51A_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.18
Assay: Binding constant for PIP5K1A kinase domain
Drug: fedratinib
Target: Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (Kinase)
Gene: PIP4K2B
UniProt: P78356 (PI42B_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.8
Assay: Binding constant for PIP5K2B kinase domain
Drug: fedratinib
Target: Myosin light chain kinase family member 4 (Kinase)
Gene: MYLK4
UniProt: Q86YV6 (MYLK4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.89
Assay: Binding constant for MYLK4 kinase domain
Drug: fedratinib
Target: Wee1-like protein kinase (Kinase)
Gene: WEE1
UniProt: P30291 (WEE1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.41
Assay: Binding constant for WEE1 kinase domain
Drug: fedratinib
Target: Serine/threonine-protein kinase 25 (Kinase)
Gene: STK25
UniProt: O00506 (STK25_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.14
Assay: Binding constant for YSK1 kinase domain
Drug: fedratinib
Target: Mitogen-activated protein kinase kinase kinase MLT (Kinase)
Gene: ZAK
UniProt: Q9NYL2 (MLTK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.19
Assay: Binding constant for ZAK kinase domain
Drug: fedratinib
Target: Protein-tyrosine kinase 2-beta (Kinase)
Gene: PTK2B
UniProt: Q14289 (FAK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.66
Assay: Binding constant for PYK2 kinase domain
Drug: fedratinib
Target: Serine/threonine-protein kinase RIO1 (Kinase)
Gene: RIOK1
UniProt: Q9BRS2 (RIOK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7
Assay: Binding constant for RIOK1 kinase domain
Drug: fedratinib
Target: Tyrosine-protein kinase receptor Tie-1 (Kinase)
Gene: TIE1
UniProt: P35590 (TIE1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.16
Assay: Binding constant for TIE1 kinase domain
Drug: fedratinib
Target: Serine/threonine-protein kinase tousled-like 1 (Kinase)
Gene: TLK1
UniProt: Q9UKI8 (TLK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.89
Assay: Binding constant for TLK1 kinase domain
Drug: fedratinib
Target: Serine/threonine-protein kinase tousled-like 2 (Kinase)
Gene: TLK2
UniProt: Q86UE8 (TLK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.7
Assay: Binding constant for TLK2 kinase domain
Drug: fedratinib
Target: NT-3 growth factor receptor (Kinase)
Gene: NTRK3
UniProt: Q16288 (NTRK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.07
Assay: Binding constant for TRKC kinase domain
Drug: fedratinib
Target: Tyrosine-protein kinase TXK (Kinase)
Gene: TXK
UniProt: P42681 (TXK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.82
Assay: Binding constant for TXK kinase domain
Drug: fedratinib
Target: Casein kinase II subunit alpha (Kinase)
Gene: CSNK2A1
UniProt: P68400 (CSK21_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.04
Assay: Binding constant for CSNK2A1 kinase domain
Drug: fedratinib
Target: Casein kinase II subunit alpha' (Kinase)
Gene: CSNK2A2
UniProt: P19784 (CSK22_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.92
Assay: Binding constant for CSNK2A2 kinase domain
Drug: fedratinib
Target: Dual specificity tyrosine-phosphorylation-regulated kinase 1B (Kinase)
Gene: DYRK1B
UniProt: Q9Y463 (DYR1B_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.02
Assay: Binding constant for DYRK1B kinase domain
Drug: fedratinib
Target: Inhibitor of nuclear factor kappa-B kinase subunit epsilon (Kinase)
Gene: IKBKE
UniProt: Q14164 (IKKE_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.44
Assay: Binding constant for IKK-epsilon kinase domain
Drug: fedratinib
Target: LIM domain kinase 2 (Kinase)
Gene: LIMK2
UniProt: P53671 (LIMK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.1
Assay: Binding constant for LIMK2 kinase domain
Drug: fedratinib
Target: Serine/threonine-protein kinase STK11 (Kinase)
Gene: STK11
UniProt: Q15831 (STK11_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.51
Assay: Binding constant for LKB1 kinase domain
Drug: fedratinib
Target: Dual specificity mitogen-activated protein kinase kinase 3 (Kinase)
Gene: MAP2K3
UniProt: P46734 (MP2K3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.46
Assay: Binding constant for MEK3 kinase domain
Drug: fedratinib
Target: Maternal embryonic leucine zipper kinase (Kinase)
Gene: MELK
UniProt: Q14680 (MELK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.58
Assay: Binding constant for MELK kinase domain
Drug: fedratinib
Target: MAP kinase-interacting serine/threonine-protein kinase 1 (Kinase)
Gene: MKNK1
UniProt: Q9BUB5 (MKNK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.14
Assay: Binding constant for MKNK1 kinase domain
Drug: fedratinib
Target: Serine/threonine-protein kinase 26 (Kinase)
Gene: STK26
UniProt: Q9P289 (STK26_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.12
Assay: Binding constant for MST4 kinase domain
Drug: fedratinib
Target: Serine/threonine-protein kinase Nek7 (Kinase)
Gene: NEK7
UniProt: Q8TDX7 (NEK7_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.8
Assay: Binding constant for NEK7 kinase domain
Drug: fedratinib
Target: Eukaryotic translation initiation factor 2-alpha kinase 4 (Kinase)
Gene: EIF2AK4
UniProt: Q9P2K8 (E2AK4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7
Assay: Binding constant for GCN2(Kin.Dom.2,S808G) kinase domain
Drug: fedratinib
Target: Insulin receptor-related protein (Kinase)
Gene: INSRR
UniProt: P14616 (INSRR_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.8
Assay: Binding constant for INSRR kinase domain
Drug: fedratinib
Target: Interleukin-1 receptor-associated kinase 3 (Kinase)
Gene: IRAK3
UniProt: Q9Y616 (IRAK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.92
Assay: Binding constant for IRAK3 kinase domain
Drug: fedratinib
Target: Serine/threonine-protein kinase RIO3 (Kinase)
Gene: RIOK3
UniProt: O14730 (RIOK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.04
Assay: Binding constant for RIOK3 kinase domain
Drug: fedratinib
Target: Serine/threonine-protein kinase SIK2 (Kinase)
Gene: SIK2
UniProt: Q9H0K1 (SIK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.01
Assay: Binding constant for SIK2 kinase domain
Drug: fedratinib
Target: SRSF protein kinase 1 (Kinase)
Gene: SRPK1
UniProt: Q96SB4 (SRPK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.8
Assay: Binding constant for SRPK1 kinase domain
Drug: fedratinib
Target: SRSF protein kinase 2 (Kinase)
Gene: SRPK2
UniProt: P78362 (SRPK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7
Assay: Binding constant for SRPK2 kinase domain
Drug: fedratinib
Target: Serine/threonine-protein kinase 33 (Kinase)
Gene: STK33
UniProt: Q9BYT3 (STK33_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.66
Assay: Binding constant for STK33 kinase domain
Drug: fedratinib
Target: Serine/threonine-protein kinase TNNI3K (Kinase)
Gene: TNNI3K
UniProt: Q59H18 (TNI3K_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.75
Assay: Binding constant for TNNI3K kinase domain
Drug: fedratinib
Target: 5'-AMP-activated protein kinase catalytic subunit alpha-2 (Kinase)
Gene: PRKAA2
UniProt: P54646 (AAPK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.33
Assay: Binding constant for AMPK-alpha2 kinase domain
Drug: fedratinib
Target: Ankyrin repeat and protein kinase domain-containing protein 1 (Kinase)
Gene: ANKK1
UniProt: Q8NFD2 (ANKK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.37
Assay: Binding constant for ANKK1 kinase domain
Drug: fedratinib
Target: Discoidin domain-containing receptor 2 (Kinase)
Gene: DDR2
UniProt: Q16832 (DDR2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.02
Assay: Binding constant for DDR2 kinase domain
Drug: fedratinib
Target: Myotonin-protein kinase (Kinase)
Gene: DMPK
UniProt: Q09013 (DMPK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6
Assay: Binding constant for DMPK kinase domain
Drug: fedratinib
Target: Chaperone activity of bc1 complex-like, mitochondrial (Kinase)
Gene: COQ8A
UniProt: Q8NI60 (COQ8A_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.16
Assay: Binding constant for ADCK3 kinase domain