AIM-Harvard/TrialPanorama-filtered huggingface dataset:
Drug: cyclomethycaine
Target: Sodium channel alpha subunits; brain (Types I, II, III) (Ion channel)
Gene: SCN1A|SCN2A|SCN3A
UniProt: P35498|Q99250|Q9NY46 (SCN1A_HUMAN|SCN2A_HUMAN|SCN3A_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.7
Assay: Inhibition of binding of Batrachotoxinin [3H]BTX-B to high affinity sites on voltage dependent sodium channels in a vesicular preparation from guinea pig cerebral cortex
Drug: cynarine
Target: Integrase (Enzyme)
Gene: pol
UniProt: Q7ZJM1 (Q7ZJM1_9HIV1)
Organism: Human immunodeficiency virus 1
Activity: IC50 = 5.8
Drug: demoxytocin
Target: Oxytocin receptor (GPCR)
Gene: Oxtr
UniProt: P70536 (OXYR_RAT)
Organism: Rattus norvegicus
Activity: Ki = 9.05
Assay: Binding affinity against Oxytocin receptor was determined in rat uterine membrane using radioligand [3H]oxytocin
Drug: desomorphine
Target: Opioid receptor (GPCR)
Gene: Oprd1|Oprm1|Oprk1|Sigmar1
UniProt: P33533|P33535|P34975|Q9R0C9 (OPRD_RAT|OPRM_RAT|OPRK_RAT|SGMR1_RAT)
Organism: Rattus norvegicus
Activity: EC50 = 9.22
Assay: Binding affinity to opioid receptor in rat brain homogenates
Drug: desonide
Target: Glucocorticoid receptor (Nuclear hormone receptor)
Gene: NR3C1
UniProt: P04150 (GCR_HUMAN)
Organism: Homo sapiens
Action type: AGONIST
Assay: Mechanism of Action; CHEMBL2034; SINGLE PROTEIN
Drug: dibrompropamidine
Target: Urokinase-type plasminogen activator (Enzyme)
Gene: PLAU
UniProt: P00749 (UROK_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.8
Assay: compound was tested for inhibitory activity against Urokinase-type plasminogen activator (microPa)
Drug: dibrompropamidine
Target: Prothrombin (Enzyme)
Gene: F2
UniProt: P00734 (THRB_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.02
Assay: compound was tested for inhibitory activity against Thrombin
Drug: dibrompropamidine
Target: Suppressor of tumorigenicity 14 protein (Enzyme)
Gene: ST14
UniProt: Q9Y5Y6 (ST14_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.27
Assay: compound was tested for inhibitory activity against Matriptase
Drug: dibrompropamidine
Target: Acrosin (Enzyme)
Gene: ACR
UniProt: P08001 (ACRO_PIG)
Organism: Sus scrofa
Activity: Ki = 5.77
Assay: Reversible competitive inhibition of boar spermatozoa acrosin using BzArgOEt as substrate by Dixon plot analysis
Drug: difluprednate
Target: Glucocorticoid receptor (Nuclear hormone receptor)
Gene: NR3C1
UniProt: P04150 (GCR_HUMAN)
Organism: Homo sapiens
Action type: AGONIST
Assay: Mechanism of Action; CHEMBL2034; SINGLE PROTEIN
Drug: quinisocaine
Target: Sodium channel alpha subunits; brain (Types I, II, III) (Ion channel)
Gene: SCN1A|SCN2A|SCN3A
UniProt: P35498|Q99250|Q9NY46 (SCN1A_HUMAN|SCN2A_HUMAN|SCN3A_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.47
Assay: Inhibition of binding of Batrachotoxinin [3H]BTX-B to high affinity sites on voltage dependent sodium channels in a vesicular preparation from guinea pig cerebral cortex
Drug: diosmin
Target: Lysine-specific histone demethylase 1A (Enzyme)
Gene: KDM1A
UniProt: O60341 (KDM1A_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.99
Assay: Inhibition of LSD1 (unknown origin) by fluorescence assay
Drug: dioxadrol
Target: Sigma non-opioid intracellular receptor 1 (Membrane other)
Gene: SIGMAR1
UniProt: Q60492 (SGMR1_CAVPO)
Organism: Cavia porcellus
Activity: Ki = 7.46
Assay: Displacement of [3H](+)-pentazocine from sigma1 opioid receptor from guinea pig brain cortex after 150 mins by scintillation counting
Drug: disufenton
Target: Lipoxygenase (Unclassified)
UniProt: Q39829 (Q39829_SOYBN)
Organism: Glycine max
Activity: IC50 = 4.24
Assay: Inhibition of soybean lipoxygenase using sodium linoleate as substrate by UV-based analysis
Drug: domitroban
Target: Thromboxane A2 receptor (GPCR)
Gene: TBXA2R
UniProt: P21731 (TA2R_HUMAN)
Organism: Homo sapiens
Activity: Ki = 9.6
Action type: ANTAGONIST
Drug: domitroban
Target: Thromboxane A2 receptor (GPCR)
Gene: Tbxa2r
UniProt: P30987 (TA2R_MOUSE)
Organism: Mus musculus
Activity: Ki = 9.2
Action type: ANTAGONIST
Drug: eburnamonine
Target: Muscarinic acetylcholine receptor M1 (GPCR)
Gene: CHRM1
UniProt: P11229 (ACM1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.1
Action type: ALLOSTERIC MODULATOR
Drug: eburnamonine
Target: Muscarinic acetylcholine receptor M2 (GPCR)
Gene: CHRM2
UniProt: P08172 (ACM2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 4.2
Action type: ALLOSTERIC MODULATOR
Drug: eburnamonine
Target: Muscarinic acetylcholine receptor M3 (GPCR)
Gene: CHRM3
UniProt: P20309 (ACM3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.2
Action type: ALLOSTERIC MODULATOR
Drug: eburnamonine
Target: Muscarinic acetylcholine receptor M4 (GPCR)
Gene: CHRM4
UniProt: P08173 (ACM4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 4.6
Action type: ALLOSTERIC MODULATOR
Drug: edoxudine
Target: Thymidine kinase (Kinase)
Gene: UL23
UniProt: A3RLP8 (A3RLP8_CHV1)
Organism: Cercopithecine herpesvirus 1
Activity: IC50 = 6.82
Assay: Inhibition of Herpes B virus recombinant thymidine kinase-mediated [3H]TdR phosphorylation
Drug: eicosapentaenoic acid
Target: Aromatase (Enzyme)
Gene: CYP19A1
UniProt: P11511 (CP19A_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.27
Assay: Inhibition of aromatase in human placental microsomes by radiometric method
Drug: eicosapentaenoic acid
Target: Peroxisome proliferator-activated receptor alpha (Nuclear hormone receptor)
Gene: PPARA
UniProt: Q07869 (PPARA_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.96
Assay: Inhibition of PPAR-alpha (unknown origin) by SPA assay
Drug: eicosapentaenoic acid
Target: Peroxisome proliferator-activated receptor gamma (Nuclear hormone receptor)
Gene: PPARG
UniProt: P37231 (PPARG_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.7
Assay: Binding affinity to PPARgamma
Drug: eicosapentaenoic acid
Target: Retinoic acid receptor RXR-alpha (Nuclear hormone receptor)
Gene: RXRA
UniProt: P19793 (RXRA_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.12
Assay: Displacement of CU-6PMN from human RXRalpha LBD incubated for 2 hrs by fluorescence based assay
Drug: eicosapentaenoic acid
Target: Peroxisome proliferator-activated receptor delta (Nuclear hormone receptor)
Gene: PPARD
UniProt: Q03181 (PPARD_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.4
Assay: Displacement of [3H]GW2433 from Homo sapiens (human) PPARdelta receptor by scintillation proximity assay
Drug: eicosapentaenoic acid
Target: Tissue factor (Membrane receptor)
Gene: F3
UniProt: P13726 (TF_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.11
Assay: Inhibition of amidolytic activity of human tissue factor/human factor 7a
Drug: eicosapentaenoic acid
Target: Prostaglandin G/H synthase 2 (Enzyme)
Gene: PTGS2
UniProt: P79208 (PGH2_SHEEP)
Organism: Ovis aries
Activity: IC50 = 5.15
Assay: Inhibition of sheep COX2-mediated prostaglandin biosynthesis using [1-14C]arachidonic acid
Drug: eicosapentaenoic acid
Target: Prostaglandin G/H synthase 1 (Enzyme)
Gene: PTGS1
UniProt: O62664 (PGH1_BOVIN)
Organism: Bos taurus
Activity: IC50 = 4.89
Assay: Inhibition of bovine COX1-mediated prostaglandin biosynthesis using [1-14C]arachidonic acid
Drug: eicosapentaenoic acid
Target: Oxoeicosanoid receptor 1 (GPCR)
Gene: OXER1
UniProt: Q8TDS5 (OXER1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.7
Assay: Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis
Drug: eicosapentaenoic acid
Target: Retinoic acid receptor RXR-alpha (Nuclear other)
Gene: RXRA
UniProt: P19793 (RXRA_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.12
Assay: Displacement of CU-6PMN from human RXRalpha LBD incubated for 2 hrs by fluorescence based assay
Drug: enilconazole
Target: Indoleamine 2,3-dioxygenase 1 (Enzyme)
Gene: IDO1
UniProt: P14902 (I23O1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.64
Drug: enoxolone
Target: Arachidonate 5-lipoxygenase (Enzyme)
Gene: ALOX5
UniProt: P09917 (LOX5_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.61
Assay: Inhibition of human recombinant 5-LOX expressed in insect cells assessed as decrease in production of 5-HPETE and 5-HETE using arachidonic acid as substrate preincubated for 5 mins followed by substrate addition measured after 20 mins in dark by ferric ion oxidation-xylenol orange method
Drug: enoxolone
Target: Tyrosine-protein phosphatase non-receptor type 1 (Enzyme)
Gene: PTPN1
UniProt: P18031 (PTN1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.34
Assay: Inhibition of recombinant PTP1B
Drug: enoxolone
Target: Liver carboxylesterase 1 (Enzyme)
Gene: CES1
UniProt: P23141 (EST1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.68
Assay: Inhibition of CE1 in human liver microsomes using 2-(2-Benzoyl-3-methoxyphenyl) benzothiazole as substrate preincubated for 10 mins followed by substrate addition measured after 30 mins by LC-UV analysis
Drug: enoxolone
Target: Protein kinase C eta type (Kinase)
Gene: PRKCH
UniProt: P24723 (KPCL_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.6
Assay: Binding affinity to recombinant human PKCeta in after 2 hrs by microequilibrium dialysis assay
Drug: enoxolone
Target: Corticosteroid 11-beta-dehydrogenase isozyme 2 (Enzyme)
Gene: HSD11B2
UniProt: P80365 (DHI2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 8.91
Assay: Inhibition of human 11beta-HSD2
Drug: enoxolone
Target: Corticosteroid 11-beta-dehydrogenase isozyme 1 (Enzyme)
Gene: HSD11B1
UniProt: P28845 (DHI1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 8.07
Assay: Inhibition of human 11beta HSD1 expressed in HEK293 cells assessed as assessed as inhibition of [1,2-(n)3H]cortisone to [3H]-cortisol after 60 mins by scintillation proximity assay
Drug: enoxolone
Target: Glycogen phosphorylase, muscle form (Enzyme)
Gene: PYGM
UniProt: P00489 (PYGM_RABIT)
Organism: Oryctolagus cuniculus
Activity: IC50 = 4.18
Assay: Inhibition of rabbit muscle glycogen phosphorylase A assessed as phosphate release from glucose-1-phosphate
Drug: enoxolone
Target: Cocaine esterase (Enzyme)
Gene: CES2
UniProt: O00748 (EST2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.16
Assay: Inhibition of CE2 in human liver microsomes using fluorescein diacetate as substrate preincubated for 10 mins followed by substrate addition measured after 30 mins by LC-UV analysis
Drug: enoxolone
Target: Corticosteroid 11-beta-dehydrogenase isozyme 1 (Enzyme)
Gene: Hsd11b1
UniProt: P50172 (DHI1_MOUSE)
Organism: Mus musculus
Activity: IC50 = 8.7
Assay: Inhibition of mouse 11beta-HSD1 expressed in HEK293 cell microsomes assessed as inhibition of [3H]cortisone conversion to [3H]cortisol by scintillation proximity assay
Drug: enoxolone
Target: Aldo-keto reductase family 1 member B10 (Enzyme)
Gene: AKR1B10
UniProt: O60218 (AK1BA_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.31
Assay: Inhibition of reductase activity of N-terminal 6His-tagged human AKR1B10 expressed in Escherichia coli BL21(DE3) assessed as pyridine-3-aldehyde reduction
Drug: enoxolone
Target: Corticosteroid 11-beta-dehydrogenase isozyme 1 (Enzyme)
Gene: Hsd11b1
UniProt: P16232 (DHI1_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 7.05
Assay: Inhibition of 11beta-HSD1 in rat liver assessed as cortisone level
Drug: enoxolone
Target: Corticosteroid 11-beta-dehydrogenase isozyme 2 (Enzyme)
Gene: Hsd11b2
UniProt: P50233 (DHI2_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 6.44
Assay: Inhibition of rat renal 11beta-HSD2 in rat liver assessed as inhibition of cortisone production
Drug: enoxolone
Target: Tyrosine-protein phosphatase non-receptor type 11 (Enzyme)
Gene: PTPN11
UniProt: Q06124 (PTN11_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.02
Assay: Inhibition of recombinant SHP2
Drug: enoxolone
Target: Protein-tyrosine phosphatase 1C (Enzyme)
Gene: PTPN6
UniProt: P29350 (PTN6_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.18
Assay: Inhibition of recombinant SHP1
Drug: enoxolone
Target: High mobility group protein B1 (Nuclear other)
Gene: HMGB1
UniProt: P09429 (HMGB1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 4.06
Assay: Binding affinity to recombinant HMGB1 B box region (90 to 175 residues) (unknown origin) expressed Escherichia coli after 5 mins by fluorescence-based assay
Drug: enoxolone
Target: Lactoylglutathione lyase (Enzyme)
Gene: Glo1
UniProt: Q9CPU0 (LGUL_MOUSE)
Organism: Mus musculus
Activity: Ki = 6.54
Assay: Inhibition of recombinant mouse Glyoxalase-1 expressed in Escherichia coli BL21 (DE3) pLysS cells using GSH and MGO as substrate by Dixon plot
Drug: eseridine
Target: Acetylcholinesterase (Enzyme)
Gene: ACHE
UniProt: P22303 (ACES_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.82
Assay: Ex vivo inhibition of human erythrocyte Acetylcholinesterase.
Drug: eseridine
Target: Cholinesterase (Enzyme)
Gene: BCHE
UniProt: P06276 (CHLE_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7.92
Assay: Ex vivo inhibition of human plasma Butyrylcholinesterase.
Drug: eseridine
Target: Acetylcholinesterase (Enzyme)
Gene: ache
UniProt: P04058 (ACES_TORCA)
Organism: Torpedo californica
Activity: IC50 = 5.76
Drug: estriol
Target: Sodium-dependent serotonin transporter (Transporter)
Gene: SLC6A4
UniProt: P31645 (SC6A4_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.26
Assay: DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine)
Drug: estriol
Target: Glucocorticoid receptor (Nuclear hormone receptor)
Gene: NR3C1
UniProt: P04150 (GCR_HUMAN)
Organism: Homo sapiens
Activity: Ki = 4.748
Assay: DRUGMATRIX: Glucocorticoid radioligand binding (ligand: [3H] Dexamethasone)
Drug: estriol
Target: Estrogen receptor (Nuclear hormone receptor)
Gene: ESR1
UniProt: P03372 (ESR1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.67
Action type: AGONIST
Drug: estriol
Target: Estrogen receptor beta (Nuclear hormone receptor)
Gene: ESR2
UniProt: Q92731 (ESR2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.4
Action type: AGONIST
Drug: estriol
Target: Corticosteroid-binding globulin (Secreted)
Gene: SERPINA6
UniProt: P08185 (CBG_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5
Drug: estriol
Target: Sex hormone-binding globulin (Secreted)
Gene: SHBG
UniProt: P04278 (SHBG_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.63
Assay: Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulin
Drug: estriol
Target: Arachidonate 15-lipoxygenase (Enzyme)
Gene: ALOX15
UniProt: P12530 (LOX15_RABIT)
Organism: Oryctolagus cuniculus
Activity: IC50 = 5.064
Assay: DRUGMATRIX: Lipoxygenase 15-LO enzyme inhibition (substrate: Linoleic acid)
Drug: estriol
Target: Lanosterol 14-alpha demethylase (Enzyme)
Gene: cyp51
UniProt: P9WPP9 (CP51_MYCTU)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Activity: Kd = 4
Assay: Binding affinity to Mycobacterium tuberculosis His4-tagged recombinant CYP51 substrate binding site expressed in Escherichia coli HMS174(DE3) by UV-visible spectral titration method
Drug: estriol
Target: Olfactory receptor 51E2 (GPCR)
Gene: OR51E2
UniProt: Q9H255 (O51E2_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 4.28
Assay: Agonist activity at PSGR/OR51E2 (unknown origin) expressed in human Hana3A cells co-transfected with CRE-Luc by luciferase reporter gene assay
Drug: estrone
Target: Sodium-dependent serotonin transporter (Transporter)
Gene: SLC6A4
UniProt: P31645 (SC6A4_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.55
Assay: DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine)
Drug: estrone
Target: 5-hydroxytryptamine receptor 2B (GPCR)
Gene: HTR2B
UniProt: P41595 (5HT2B_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.062
Assay: DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
Drug: estrone
Target: Estrogen receptor (Nuclear hormone receptor)
Gene: ESR1
UniProt: P03372 (ESR1_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 9.15
Action type: AGONIST
Assay: Activation of estrogen response element in HeLa cells stably transfected with human Estrogen receptor alpha.
Drug: estrone
Target: Estrogen receptor beta (Nuclear hormone receptor)
Gene: ESR2
UniProt: Q92731 (ESR2_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 8.68
Assay: Activation of estrogen response element in HeLa cells stably transfected with human Estrogen receptor beta.
Drug: estrone
Target: Aromatase (Enzyme)
Gene: CYP19A1
UniProt: P11511 (CP19A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.6
Assay: Competitive inhibition of human aromatase extracted from placental microsomes after 5 mins by Dixon plot analysis in presence of [1beta-3H]AD
Drug: estrone
Target: Corticosteroid-binding globulin (Secreted)
Gene: SERPINA6
UniProt: P08185 (CBG_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5
Drug: estrone
Target: Steryl-sulfatase (Enzyme)
Gene: STS
UniProt: P08842 (STS_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.29
Assay: Inhibition of human steroid sulfatase using 4-methylumbelliferyl sulfate substrate after 10 mins by fluorescence assay
Drug: estrone
Target: Sex hormone-binding globulin (Secreted)
Gene: SHBG
UniProt: P04278 (SHBG_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.18
Assay: Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulin
Drug: estrone
Target: Estradiol 17-beta-dehydrogenase 1 (Enzyme)
Gene: HSD17B1
UniProt: P14061 (DHB1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.52
Assay: Inhibition of 17beta-HSD1 assessed as conversion of [14C]estradiol to [14C]estrone using NADP+
Drug: estrone
Target: Androgen receptor (Transcription factor)
Gene: Ar
UniProt: P15207 (ANDR_RAT)
Organism: Rattus norvegicus
Activity: Ki = 5.111
Assay: DRUGMATRIX: Androgen (Testosterone) AR radioligand binding (ligand: [3H] Mibolerone)
Drug: estrone
Target: Arachidonate 15-lipoxygenase (Enzyme)
Gene: ALOX15
UniProt: P12530 (LOX15_RABIT)
Organism: Oryctolagus cuniculus
Activity: IC50 = 5.181
Assay: DRUGMATRIX: Lipoxygenase 15-LO enzyme inhibition (substrate: Linoleic acid)
Drug: estrone
Target: Progesterone receptor (Transcription factor)
Gene: PGR
UniProt: Q690N0 (Q690N0_BOVIN)
Organism: Bos taurus
Activity: Ki = 5.678
Assay: DRUGMATRIX: Progesterone radioligand binding (ligand: [3H] R-5020)
Drug: ethacridine
Target: Telomerase reverse transcriptase (Enzyme)
Gene: TERT
UniProt: O14746 (TERT_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.09
Assay: Inhibitory activity against telomerase (Compound released from RNA/DNA heteroduplex derivatized resin [sequence (TTAGGG)3)
Drug: ethacridine
Target: Reverse transcriptase (Enzyme)
Gene: reverse transcriptas
UniProt: Q9WKE8 (Q9WKE8_9HIV1)
Organism: Human immunodeficiency virus 1
Activity: IC50 = 4.7
Assay: Inhibition of HIV-1 reverse transcriptase using Poly(rA).p(dT) (12 to 18) as substrate after 30 mins by single point PCR assay
Drug: kainic acid
Target: Adenosine receptor A3 (GPCR)
Gene: ADORA3
UniProt: P0DMS8 (AA3R_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7.11
Assay: Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug: kainic acid
Target: Glutamate receptor 1 (Ion channel)
Gene: GRIA1
UniProt: P42261 (GRIA1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.13
Assay: Compound was tested for binding affinity against human Ionotropic glutamate receptor AMPA 1 in HEK293 cells using [3H]-AMPA as radioligand
Drug: kainic acid
Target: Glutamate receptor ionotropic, kainate 1 (Ion channel)
Gene: GRIK1
UniProt: P39086 (GRIK1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.75
Assay: Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]kainate as radioligand
Drug: kainic acid
Target: Glutamate receptor 2 (Ion channel)
Gene: GRIA2
UniProt: P42262 (GRIA2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 4.91
Assay: Compound was tested for binding affinity against human Ionotropic glutamate receptor AMPA 2 in HK293 cells using [3H]AMPA as radioligand
Drug: kainic acid
Target: Glutamate receptor ionotropic, kainate 5 (Ion channel)
Gene: GRIK5
UniProt: Q16478 (GRIK5_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.1
Assay: Ability to bind to Ionotropic glutamate receptor kainate (kainate 2) was evaluated.
Drug: kainic acid
Target: Glutamate receptor 4 (Ion channel)
Gene: GRIA4
UniProt: P48058 (GRIA4_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.77
Assay: Compound was tested for binding affinity against human Ionotropic glutamate receptor AMPA 4 in HEK293 cells using [3H]AMPA as radioligand
Drug: kainic acid
Target: Glutamate receptor ionotropic, kainate 2 (Ion channel)
Gene: GRIK2
UniProt: Q13002 (GRIK2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.49
Assay: Binding affinity against human ionotropic glutamate receptor ionotropic kainate 2 in HEK293 cells using [3H]kainate as radioligand
Drug: kainic acid
Target: Glutamate receptor ionotropic, kainate 3 (Ion channel)
Gene: GRIK3
UniProt: Q13003 (GRIK3_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8
Assay: Ability to bind to Ionotropic glutamate receptor ionotropic kainate 3 was evaluated
Drug: kainic acid
Target: Glutamate receptor 2 (Ion channel)
Gene: Gria2
UniProt: P19491 (GRIA2_RAT)
Organism: Rattus norvegicus
Activity: Ki = 5.43
Assay: Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR2(R) expressed in Sf9 cells
Drug: kainic acid
Target: Glutamate receptor 3 (Ion channel)
Gene: GRIA3
UniProt: P42263 (GRIA3_HUMAN)
Organism: Homo sapiens
Activity: Ki  5.58
Drug: kainic acid
Target: Glutamate receptor ionotropic, kainate 4 (Ion channel)
Gene: GRIK4
UniProt: Q16099 (GRIK4_HUMAN)
Organism: Homo sapiens
Activity: Ki  8.64
Drug: kainic acid
Target: Glutamate receptor ionotropic, kainate 2 (Ion channel)
Gene: Grik2
UniProt: P42260 (GRIK2_RAT)
Organism: Rattus norvegicus
Activity: Ki = 8.43
Assay: Inhibition of [3H]kainate binding at rat forebrain ionotropic glutamate receptor kainate 2
Drug: kainic acid
Target: Glutamate receptor ionotropic, kainate 1 (Ion channel)
Gene: Grik1
UniProt: P22756 (GRIK1_RAT)
Organism: Rattus norvegicus
Activity: Ki = 7.15
Assay: Displacement of [3H]SYM2081 from rat recombinant iGluR5
Drug: kainic acid
Target: Glutamate receptor 1 (Ion channel)
Gene: Gria1
UniProt: P19490 (GRIA1_RAT)
Organism: Rattus norvegicus
Activity: Ki = 6.32
Assay: Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR1 expressed in Sf9 cells
Drug: kainic acid
Target: Glutamate receptor 3 (Ion channel)
Gene: Gria3
UniProt: P19492 (GRIA3_RAT)
Organism: Rattus norvegicus
Activity: Ki = 5.7
Assay: Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR3 expressed in Sf9 cells
Drug: kainic acid
Target: Glutamate receptor 4 (Ion channel)
Gene: Gria4
UniProt: P19493 (GRIA4_RAT)
Organism: Rattus norvegicus
Activity: Ki = 5.45
Assay: Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR4 expressed in Sf9 cells
Drug: kainic acid
Target: Glutamate receptor ionotropic, kainate 4 (Ion channel)
Gene: Grik4
UniProt: Q01812 (GRIK4_RAT)
Organism: Rattus norvegicus
Activity: Ki = 8.33
Assay: Binding affinity to rat cloned KA1 receptor
Drug: kainic acid
Target: Glutamate receptor ionotropic, kainate 5 (Ion channel)
Gene: Grik5
UniProt: Q63273 (GRIK5_RAT)
Organism: Rattus norvegicus
Activity: Ki = 7.82
Assay: Binding affinity to rat cloned KA2 receptor
Drug: kainic acid
Target: Glutamate receptor ionotropic, kainate 3 (Ion channel)
Gene: Grik3
UniProt: P42264 (GRIK3_RAT)
Organism: Rattus norvegicus
Activity: Ki = 8.42
Assay: Displacement of [3H]SYM2081 from rat recombinant iGluR7
Drug: kainic acid
Target: Glutamate receptor ionotropic, AMPA (Ion channel)
Gene: Gria1|Gria2|Gria3|Gria4
UniProt: P19490|P19491|P19492|P19493 (GRIA1_RAT|GRIA2_RAT|GRIA3_RAT|GRIA4_RAT)
Organism: Rattus norvegicus
Activity: Ki = 7.53
Assay: Displacement of [3H]SYM2081 from kainate receptor in rat brain membrane
Drug: kainic acid
Target: Glutamate receptor ionotropic, kainate (Ion channel)
Gene: Grik1|Grik2|Grik3|Grik4|Grik5
UniProt: P22756|P42260|P42264|Q01812|Q63273 (GRIK1_RAT|GRIK2_RAT|GRIK3_RAT|GRIK4_RAT|GRIK5_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 8.37
Assay: Compound was evaluated for the inhibition of [3H]-KA binding to Ionotropic glutamate receptor kainate from rat brain synaptic membrane.
Drug: nordefrin
Target: Adrenergic receptor alpha-2 (GPCR)
Gene: Adra2b|Adra2c|Adra2a
UniProt: P19328|P22086|P22909 (ADA2B_RAT|ADA2C_RAT|ADA2A_RAT)
Organism: Rattus norvegicus
Activity: Ki = 8.11
Assay: Displacement of [3H]clonidine from Alpha-2 adrenergic receptor of rat brain membranes