AIM-Harvard/TrialPanorama-filtered huggingface dataset:
Drug: flurbiprofen
Target: Prostaglandin G/H synthase 1 (Enzyme)
Gene: PTGS1
UniProt: P23219 (PGH1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 8.74
Action type: INHIBITOR
Drug: flurbiprofen
Target: Aldo-keto reductase family 1 member C2 (Enzyme)
Gene: AKR1C2
UniProt: P52895 (AK1C2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.49
Assay: Inhibition of human recombinant N-terminal His6-tagged AKR1C2 expressed in Escherichia coli BL21(DE3) cells using 8-Acetyl-2,3,5,6-tetrahydro-1H,4H-11-oxa-3a-aza-benzo[de]anthracen-10-one as substrate after 1 hr by fluorimetric analysis
Drug: flurbiprofen
Target: Aldo-keto reductase family 1 member C3 (Enzyme)
Gene: AKR1C3
UniProt: P42330 (AK1C3_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.81
Assay: Inhibition of human recombinant N-terminal His6-tagged AKR1C3 expressed in Escherichia coli BL21(DE3) cells using 8-Acetyl-2,3,5,6-tetrahydro-1H,4H-11-oxa-3a-aza-benzo[de]anthracen-10-one as substrate after 1 hr by fluorimetric analysis
Drug: flurbiprofen
Target: Fatty acid-binding protein, intestinal (Cytosolic other)
Gene: FABP2
UniProt: P12104 (FABPI_HUMAN)
Organism: Homo sapiens
Activity: Ki = 4.59
Assay: Displacement of 1-anilinonaphthalene-8-sulphonic acid from I-FABP
Drug: flurbiprofen
Target: Fatty acid-binding protein, liver (Unclassified)
Gene: Fabp1
UniProt: P02692 (FABPL_RAT)
Organism: Rattus norvegicus
Activity: Ki = 5.93
Assay: Displacement of 1-anilinonaphthalene-8-sulphonic acid from rat recombinant L-FABP high binding affinity site expressed in Escherichia coli BL21 by competitive fluorescence displacement assay
Drug: flurbiprofen
Target: Prostaglandin G/H synthase 2 (Enzyme)
Gene: Ptgs2
UniProt: Q05769 (PGH2_MOUSE)
Organism: Mus musculus
Activity: IC50 = 6.3
Assay: Inhibition of mouse COX2
Drug: flurbiprofen
Target: Prostaglandin G/H synthase 1 (Enzyme)
Gene: PTGS1
UniProt: P05979 (PGH1_SHEEP)
Organism: Ovis aries
Activity: Ki = 6
Assay: Binding affinity of compound towards prostaglandin G/H synthase 1 was evaluated
Drug: flurbiprofen
Target: Prostaglandin G/H synthase 1 (Enzyme)
Gene: Ptgs1
UniProt: Q63921 (PGH1_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 6.77
Assay: Concentration required to inhibit cyclooxygenase-1 in rat blood
Drug: fluspirilene
Target: Beta-1 adrenergic receptor (GPCR)
Gene: ADRB1
UniProt: P08588 (ADRB1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.229
Drug: fluspirilene
Target: Beta-2 adrenergic receptor (GPCR)
Gene: ADRB2
UniProt: P07550 (ADRB2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.292
Drug: fluspirilene
Target: D(2) dopamine receptor (GPCR)
Gene: DRD2
UniProt: P14416 (DRD2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 9.436
Drug: fluspirilene
Target: Alpha-2A adrenergic receptor (GPCR)
Gene: ADRA2A
UniProt: P08913 (ADA2A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.244
Drug: fluspirilene
Target: Potassium voltage-gated channel subfamily H member 2 (Ion channel)
Gene: KCNH2
UniProt: Q12809 (KCNH2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.64
Assay: Inhibitory concentration against IKr potassium channel
Drug: fluspirilene
Target: 5-hydroxytryptamine receptor 1A (GPCR)
Gene: HTR1A
UniProt: P08908 (5HT1A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.2
Action type: ANTAGONIST
Drug: fluspirilene
Target: 5-hydroxytryptamine receptor 2A (GPCR)
Gene: HTR2A
UniProt: P28223 (5HT2A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8
Action type: ANTAGONIST
Drug: fluspirilene
Target: 5-hydroxytryptamine receptor 2B (GPCR)
Gene: HTR2B
UniProt: P41595 (5HT2B_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.82
Assay: Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting
Drug: fluspirilene
Target: 5-hydroxytryptamine receptor 6 (GPCR)
Gene: HTR6
UniProt: P50406 (5HT6R_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.93
Assay: Displacement of [3H]LSD from human 5HT6 receptor expressed in HEK293 cells after 1.5 hrs by liquid scintillation counting
Drug: fluspirilene
Target: Alpha-2B adrenergic receptor (GPCR)
Gene: ADRA2B
UniProt: P18089 (ADA2B_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.319
Drug: fluspirilene
Target: D(3) dopamine receptor (GPCR)
Gene: DRD3
UniProt: P35462 (DRD3_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.409
Drug: fluspirilene
Target: Histamine H1 receptor (GPCR)
Gene: HRH1
UniProt: P35367 (HRH1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.9
Action type: ANTAGONIST
Drug: fluspirilene
Target: 5-hydroxytryptamine receptor 1B (GPCR)
Gene: HTR1B
UniProt: P28222 (5HT1B_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.951
Drug: fluspirilene
Target: 5-hydroxytryptamine receptor 1D (GPCR)
Gene: HTR1D
UniProt: P28221 (5HT1D_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6
Action type: ANTAGONIST
Drug: fluspirilene
Target: Alpha-2C adrenergic receptor (GPCR)
Gene: ADRA2C
UniProt: P18825 (ADA2C_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.208
Drug: fluspirilene
Target: D(4) dopamine receptor (GPCR)
Gene: DRD4
UniProt: P21917 (DRD4_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.056
Drug: fluspirilene
Target: Glycine receptor subunit alpha-1 (Ion channel)
Gene: GLRA1
UniProt: P23415 (GLRA1_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 5.92
Drug: fluspirilene
Target: 5-hydroxytryptamine receptor 1E (GPCR)
Gene: HTR1E
UniProt: P28566 (5HT1E_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.6
Action type: ANTAGONIST
Drug: fluspirilene
Target: Nociceptin receptor (GPCR)
Gene: OPRL1
UniProt: P41146 (OPRX_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.3
Assay: Displacement of [125I]nociceptin from human NOP expressed in CHO cells
Drug: flutamide
Target: 5-hydroxytryptamine receptor 4 (GPCR)
Gene: HTR4
UniProt: O70528 (5HT4R_CAVPO)
Organism: Cavia porcellus
Activity: Ki = 5.646
Assay: DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT4 radioligand binding (ligand: [3H] GR-113808)
Drug: flutamide
Target: 5-hydroxytryptamine receptor 6 (GPCR)
Gene: HTR6
UniProt: P50406 (5HT6R_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.082
Assay: DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT6 radioligand binding (ligand: [3H] Lysergic acid diethylamide)
Drug: flutamide
Target: Androgen receptor (Nuclear hormone receptor)
Gene: AR
UniProt: P10275 (ANDR_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.89
Action type: ANTAGONIST
Assay: Binding affinity against GST-hARLBD was measured in SC-3 cell by using [3H]testosterone as radioligand
Drug: flutamide
Target: Cytochrome P450 1A2 (Enzyme)
Gene: CYP1A2
UniProt: P05177 (CP1A2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.356
Drug: flutamide
Target: Androgen receptor (Transcription factor)
Gene: Ar
UniProt: P15207 (ANDR_RAT)
Organism: Rattus norvegicus
Activity: Ki = 5.049
Assay: DRUGMATRIX: Androgen (Testosterone) AR radioligand binding (ligand: [3H] Mibolerone)
Drug: flutamide
Target: Bile salt export pump (Transporter)
Gene: Abcb11
UniProt: O70127 (ABCBB_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 4.1
Drug: fluticasone propionate
Target: Glucocorticoid receptor (Nuclear hormone receptor)
Gene: NR3C1
UniProt: P04150 (GCR_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 10.74
Action type: AGONIST
Drug: fluticasone propionate
Target: Mineralocorticoid receptor (Nuclear hormone receptor)
Gene: NR3C2
UniProt: P08235 (MCR_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 6.83
Action type: AGONIST
Drug: fluticasone propionate
Target: Progesterone receptor (Nuclear hormone receptor)
Gene: PGR
UniProt: P06401 (PRGR_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 9.77
Action type: AGONIST
Drug: fluticasone propionate
Target: Cytosolic phospholipase A2 (Enzyme)
Gene: PLA2G4A
UniProt: P47712 (PA24A_HUMAN)
Organism: Homo sapiens
Drug: fluticasone propionate
Target: Glucocorticoid receptor (Transcription factor)
Gene: Nr3c1
UniProt: P06536 (GCR_RAT)
Organism: Rattus norvegicus
Activity: EC50 = 9.12
Assay: Transactivation activity at glucocorticoid receptor in rat H4II-E cells assessed as induction of tyrosine amino transferase
Drug: flutrimazole
Target: Nuclear receptor subfamily 1 group I member 2 (Nuclear hormone receptor)
Gene: NR1I2
UniProt: O75469 (NR1I2_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 5.21
Assay: Agonist activity at PXR (unknown origin) expressed in human HepG2 cells assessed as induction of CYP3A4 transactivation after 16 hrs by luciferase reporter gene assay
Drug: flutrimazole
Target: Bile acid receptor (Nuclear hormone receptor)
Gene: NR1H4
UniProt: Q96RI1 (NR1H4_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.86
Assay: Antagonist activity at human GTS-tagged FXR after 20 mins by TR-FRET assay
Drug: fluvastatin
Target: Nuclear receptor subfamily 1 group I member 3 (Nuclear hormone receptor)
Gene: NR1I3
UniProt: Q14994 (NR1I3_HUMAN)
Organism: Homo sapiens
Drug: fluvastatin
Target: Cytochrome P450 2C9 (Enzyme)
Gene: CYP2C9
UniProt: P11712 (CP2C9_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.398
Assay: DRUGMATRIX: CYP450, 2C9 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)
Drug: fluvastatin
Target: Retinoic acid receptor RXR-alpha (Nuclear hormone receptor)
Gene: RXRA
UniProt: P19793 (RXRA_HUMAN)
Organism: Homo sapiens
Activity: Kd = 4.96
Assay: Binding affinity to RXRalpha-LBD (unknown origin) measured up to 120 sec by surface plasma resonance method
Drug: fluvastatin
Target: 3-hydroxy-3-methylglutaryl-coenzyme A reductase (Enzyme)
Gene: Hmgcr
UniProt: P51639 (HMDH_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 8.6
Assay: Inhibitory activity against partially purified rat liver HMG-CoA reductase in vitro; 0.0015-0.0040
Drug: fluvastatin
Target: Sodium/bile acid cotransporter (Transporter)
Gene: SLC10A1
UniProt: Q14973 (NTCP_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.4
Assay: Inhibition of human recombinant NTCP expressed in CHO cells assessed as reduction in [3H]taurocholate uptake incubated for 2 mins by scintillation counting method
Drug: fluvastatin
Target: 3-hydroxy-3-methylglutaryl-coenzyme A reductase (Enzyme)
Gene: HMGCR
UniProt: P04035 (HMDH_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7.55
Action type: INHIBITOR
Assay: Inhibitory concentration against 3-hydroxy-3-methylglutaryl-CoA reductase
Drug: fluvoxamine
Target: Sigma non-opioid intracellular receptor 1 (Membrane receptor)
Gene: SIGMAR1
UniProt: Q99720 (SGMR1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.44
Assay: Binding affinity to sigma 1 receptor
Drug: fluvoxamine
Target: Sodium-dependent serotonin transporter (Transporter)
Gene: SLC6A4
UniProt: P31645 (SC6A4_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.51
Action type: INHIBITOR
Drug: fluvoxamine
Target: Sodium-dependent noradrenaline transporter (Transporter)
Gene: SLC6A2
UniProt: P23975 (SC6A2_HUMAN)
Organism: Homo sapiens
Activity: Ki  5.951
Drug: fluvoxamine
Target: Sodium-dependent dopamine transporter (Transporter)
Gene: SLC6A3
UniProt: Q01959 (SC6A3_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.84
Assay: In vitro competitive binding versus [N-methyl-3H]WIN-35428 in murine kidney cells transfected with cDNA for human dopamine transporter (DAT)
Drug: fluvoxamine
Target: Cytochrome P450 1A2 (Enzyme)
Gene: CYP1A2
UniProt: P05177 (CP1A2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.07
Drug: fluvoxamine
Target: Sodium-dependent serotonin transporter (Transporter)
Gene: Slc6a4
UniProt: P31652 (SC6A4_RAT)
Organism: Rattus norvegicus
Activity: Ki = 8.19
Action type: INHIBITOR
Assay: Inhibition of [<sup>3</sup>]5-HT uptake into rat astrocyte cultures.
Drug: fluvoxamine
Target: Sigma non-opioid intracellular receptor 1 (Membrane receptor)
Gene: Sigmar1
UniProt: Q9R0C9 (SGMR1_RAT)
Organism: Rattus norvegicus
Activity: Ki = 7.44
Assay: Displacement of [3H]-(+)pentazocine from rat brain sigma 1-type opioid receptor
Drug: folic acid
Target: Thymidylate synthase (Enzyme)
Gene: TYMS
UniProt: P04818 (TYSY_HUMAN)
Organism: Homo sapiens
Activity: Ki = 4.4
Assay: Inhibitory constant of thymidylate synthase was determined in human AML cells
Drug: folic acid
Target: Dihydrofolate reductase (Enzyme)
Gene: dfrA17
UniProt: B0BL08 (B0BL08_ECOLX)
Organism: Escherichia coli
Activity: Kd = 6.09
Assay: Thermodynamic Dissociation Constant for compound-Phe31-dihydrofolate reductase (DHFR) complex at pH 7
Drug: leucovorin
Target: Thymidylate synthase (Enzyme)
Gene: TYMS
UniProt: P04818 (TYSY_HUMAN)
Organism: Homo sapiens
Activity: Ki = 4.071
Drug: leucovorin
Target: Dihydrofolate reductase (Enzyme)
Gene: DHFR
UniProt: P00374 (DYR_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.63
Assay: Tested for the inhibition of [14C]-DDATHF influx in CCRF-CEM cells of human leukemic lymphoblast
Drug: fomepizole
Target: Alcohol dehydrogenase (Enzyme)
Gene: ADH1B|ADH1C|ADH1A
UniProt: P00325|P00326|P07327 (ADH1B_HUMAN|ADH1G_HUMAN|ADH1A_HUMAN)
Organism: Homo sapiens
Action type: INHIBITOR
Assay: Mechanism of Action; CHEMBL2363044; PROTEIN COMPLEX GROUP
Drug: fomepizole
Target: Alcohol dehydrogenase (Enzyme)
UniProt: P00327|P00328 (ADH1E_HORSE|ADH1S_HORSE)
Organism: Equus caballus
Activity: Kd = 7.89
Assay: Inhibition of horse liver alcohol dehydrogenase using ethanol as substrate assessed as dissociation constant by spectrophotometric titration in presence of 1 mM NAD+
Drug: fondaparinux
Target: Antithrombin-III (Secreted)
Gene: SERPINC1
UniProt: P01008 (ANT3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.49
Action type: ACTIVATOR
Assay: Catalyses the inactivation of coagulation proteases by activated antithrombin-III
Drug: formestane
Target: Aromatase (Enzyme)
Gene: CYP19A1
UniProt: P11511 (CP19A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.569
Drug: formoterol
Target: Beta-1 adrenergic receptor (GPCR)
Gene: ADRB1
UniProt: P08588 (ADRB1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.5
Assay: Displacement of [3H]CGP12177 from human beta-1 adrenoceptor
Drug: formoterol
Target: Beta-2 adrenergic receptor (GPCR)
Gene: ADRB2
UniProt: P07550 (ADRB2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.6
Action type: AGONIST
Assay: Binding affinity to beta-2 adrenergic receptor (unknown origin) at 1 to 10000 nM
Drug: formoterol
Target: D(2) dopamine receptor (GPCR)
Gene: DRD2
UniProt: P14416 (DRD2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 4.89
Assay: Displacement of [3H]spiperone from human D2S receptor expressed in CHO cells
Drug: formoterol
Target: D(3) dopamine receptor (GPCR)
Gene: DRD3
UniProt: P35462 (DRD3_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.79
Drug: formoterol
Target: Beta-3 adrenergic receptor (GPCR)
Gene: ADRB3
UniProt: P13945 (ADRB3_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 7.6
Assay: Agonist activity at human recombinant beta3 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assay
Drug: formoterol
Target: Beta-2 adrenergic receptor (GPCR)
Gene: Adrb2
UniProt: Q8K4Z4 (ADRB2_CAVPO)
Organism: Cavia porcellus
Activity: EC50 = 8.8
Assay: Agonist activity at beta2 receptor in guinea pig trachea assessed as fast onset of inhibition of electrically stimulated contraction
Drug: formoterol
Target: Heat shock protein HSP 90-alpha (Cytosolic other)
Gene: HSP90AA1
UniProt: P07900 (HS90A_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 8.523
Drug: fosamprenavir
Target: Gag-Pol polyprotein (Polyprotein)
Gene: gag-pol
UniProt: P03367 (POL_HV1BR)
Organism: Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI)
Drug: fosamprenavir
Target: Pol polyprotein (Enzyme)
Gene: pol
UniProt: Q72874 (Q72874_9HIV1)
Organism: Human immunodeficiency virus 1
Action type: INHIBITOR
Assay: Mechanism of Action; CHEMBL243; SINGLE PROTEIN
Drug: foscarnet
Target: DNA polymerase catalytic subunit (Enzyme)
UniProt: P04293 (DPOL_HHV11)
Organism: Human herpesvirus 1 (strain 17)
Activity: IC50 = 4.13
Action type: INHIBITOR
Assay: Inhibition of HSV-1 DNA polymerase in HSV-1 C42 plaque reduction assay
Drug: foscarnet
Target: DNA polymerase catalytic subunit (Enzyme)
Gene: UL54
UniProt: P08546 (DPOL_HCMVA)
Organism: Human cytomegalovirus (strain AD169)
Activity: IC50 = 5.6
Assay: Inhibition of human cytomegalovirus DNA polymerase (95 uL) activity in a solution containing 6.4 mM HEPES (pH 7.5), incubation for 12 minutes at 26 degrees C
Drug: foscarnet
Target: Reverse transcriptase/RNaseH (Enzyme)
Gene: pol
UniProt: Q72547 (Q72547_9HIV1)
Organism: Human immunodeficiency virus 1
Activity: IC50 = 5.69
Assay: Inhibitory activity against HIV-1 reverse transcriptase
Drug: foscarnet
Target: Reverse transcriptase (Enzyme)
Gene: reverse transcriptas
UniProt: Q9WKE8 (Q9WKE8_9HIV1)
Organism: Human immunodeficiency virus 1
Activity: IC50 = 5.6
Drug: fosfluconazole
Target: Lanosterol 14-alpha demethylase (Enzyme)
Gene: ERG11
UniProt: P10613 (CP51_CANAL)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876)
Drug: fosfomycin
Target: UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1 (Enzyme)
Gene: murA1
UniProt: Q836E5 (MURA1_ENTFA)
Organism: Enterococcus faecalis (strain ATCC 700802 / V583)
Drug: fosfomycin
Target: UDP-N-acetylglucosamine 1-carboxyvinyltransferase 2 (Enzyme)
Gene: murA2
UniProt: Q831A8 (MURA2_ENTFA)
Organism: Enterococcus faecalis (strain ATCC 700802 / V583)
Drug: fosfomycin
Target: UDP-N-acetylglucosamine 1-carboxyvinyltransferase (Enzyme)
Gene: murA
UniProt: P0A749 (MURA_ECOLI)
Organism: Escherichia coli (strain K12)
Activity: IC50 = 7
Action type: INHIBITOR
Assay: Inhibition of Escherichia coli MurA expressed in Escherichia coli BL21(lambdaDE3) using UNAG and PEP as substrate incubated for 10 mins prior to PEP addition measured after 60 mins by spectrophotometric analysis
Drug: fosfomycin
Target: UDP-N-acetylglucosamine 1-carboxyvinyltransferase (Enzyme)
Gene: murA
UniProt: Q9HVW7 (MURA_PSEAE)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Activity: IC50 = 4.98
Assay: Inhibition of Pseudomonas aeruginosa PAO1293 MurA in presence of UNAG
Drug: fosinopril
Target: Angiotensin-converting enzyme (Enzyme)
Gene: ACE
UniProt: P12821 (ACE_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 9
Action type: INHIBITOR
Assay: Inhibitory activity against angiotensin I converting enzyme (ACE)
Drug: fosinopril
Target: Angiotensin-converting enzyme (Enzyme)
Gene: ACE
UniProt: P12822 (ACE_RABIT)
Organism: Oryctolagus cuniculus
Activity: Ki = 8.82
Drug: fosphenytoin
Target: Sodium channel protein type 5 subunit alpha (Ion channel)
Gene: SCN5A
UniProt: Q14524 (SCN5A_HUMAN)
Organism: Homo sapiens
Action type: BLOCKER
Drug: frovatriptan
Target: 5-hydroxytryptamine receptor 1A (GPCR)
Gene: HTR1A
UniProt: P08908 (5HT1A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.21
Assay: In vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1A receptor
Drug: frovatriptan
Target: 5-hydroxytryptamine receptor 1B (GPCR)
Gene: HTR1B
UniProt: P28222 (5HT1B_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.99
Action type: AGONIST
Assay: In vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1B receptor
Drug: frovatriptan
Target: 5-hydroxytryptamine receptor 1D (GPCR)
Gene: HTR1D
UniProt: P28221 (5HT1D_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.36
Action type: AGONIST
Assay: In vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor
Drug: fructose
Target: Glycine receptor subunit alpha-1 (Ion channel)
Gene: GLRA1
UniProt: P23415 (GLRA1_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 4.9
Assay: Positive allosteric modulatory activity at recombinant human glycine alpha1 receptor expressed in HEK293 cells assessed as potentiation of glycine-induced response at -50 mV holding potential in presence of fructose by whole cell patch clamp method
Drug: ftivazide
Target: Myeloperoxidase (Enzyme)
Gene: MPO
UniProt: P05164 (PERM_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.34
Assay: Inhibition of human MPO
Drug: fulvestrant
Target: Nuclear receptor subfamily 1 group I member 2 (Nuclear hormone receptor)
Gene: NR1I2
UniProt: O75469 (NR1I2_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 5.71
Assay: Agonist activity at PXR (unknown origin) expressed in human HepG2 cells assessed as induction of CYP3A4 transactivation after 16 hrs by luciferase reporter gene assay
Drug: fulvestrant
Target: Beta-lactamase TEM (Enzyme)
Gene: bla; blaT-3; blaT-4;
UniProt: P62593 (BLAT_ECOLX)
Organism: Escherichia coli
Activity: IC50 = 4.25
Assay: Inhibition of bacterial wild type Beta-lactamase TEM-1 pre-incubated for 5 mins before addition of chromogenic beta-lactamase substrate CENTA by spectrophotometry
Drug: fulvestrant
Target: Estrogen receptor (Nuclear hormone receptor)
Gene: ESR1
UniProt: P03372 (ESR1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 9.62
Action type: ANTAGONIST
Drug: fulvestrant
Target: Progesterone receptor (Nuclear hormone receptor)
Gene: PGR
UniProt: P06401 (PRGR_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 9.68
Drug: fulvestrant
Target: Estrogen receptor beta (Nuclear hormone receptor)
Gene: ESR2
UniProt: Q92731 (ESR2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.74
Action type: ANTAGONIST
Drug: fulvestrant
Target: G-protein coupled estrogen receptor 1 (GPCR)
Gene: GPER1
UniProt: Q99527 (GPER1_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 7
Drug: fulvestrant
Target: Bile acid receptor (Nuclear hormone receptor)
Gene: NR1H4
UniProt: Q96RI1 (NR1H4_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.1
Assay: Antagonist activity at human GTS-tagged FXR after 20 mins by TR-FRET assay
Drug: fulvestrant
Target: Steroid hormone receptor ERR1 (Nuclear hormone receptor)
Gene: ESRRA
UniProt: P11474 (ERR1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 8.7
Assay: Antagonist activity at ERalpha receptor in human MCF7 cells assessed as inhibition of cell growth after 6 days by crystal violet staining method
Drug: fulvestrant
Target: Bifunctional epoxide hydrolase 2 (Enzyme)
Gene: EPHX2
UniProt: P34913 (HYES_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.59
Assay: Competitive inhibition of human recombinant soluble epoxide hydrolase using [3H]-tDPPO as substrate
Drug: fulvestrant
Target: Estrogen receptor (Transcription factor)
Gene: Esr1
UniProt: P06211 (ESR1_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 8.23
Assay: Displacement of [3H]estradiol from rat uterine cytosolic estrogen receptor
Drug: furaltadone
Target: Mitogen-activated protein kinase 9 (Kinase)
Gene: MAPK9
UniProt: P45984 (MK09_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.87
Assay: Inhibition of human JNK2alpha2 using GST-c-jun (1 to 221) as substrate preincubated for 30 mins before [gamma-32P]-ATP addition measured after 10 mins by liquid scintillation counting
Drug: furosemide
Target: Solute carrier family 12 member 1 (Transporter)
Gene: SLC12A1
UniProt: Q13621 (S12A1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.2
Action type: INHIBITOR
Drug: furosemide
Target: Sodium/potassium-transporting ATPase subunit alpha-1 (Transporter)
Gene: ATP1A1
UniProt: P05023 (AT1A1_HUMAN)
Organism: Homo sapiens
Drug: furosemide
Target: Carbonic anhydrase 2 (Enzyme)
Gene: CA2
UniProt: P00918 (CAH2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.19
Assay: Inhibition of human recombinant full length CA2 by stopped-flow CO2 hydration method
Drug: furosemide
Target: Carbonic anhydrase 1 (Enzyme)
Gene: CA1
UniProt: P00915 (CAH1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.21
Assay: Inhibition of human recombinant full length CA1 by stopped-flow CO2 hydration method
Drug: furosemide
Target: Carbonic anhydrase 4 (Enzyme)
Gene: CA4
UniProt: P22748 (CAH4_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.25
Assay: Inhibition of human recombinant full length CA4 by stopped-flow CO2 hydration method
Drug: furosemide
Target: Carbonic anhydrase 9 (Enzyme)
Gene: CA9
UniProt: Q16790 (CAH9_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.38
Assay: Inhibition of human recombinant CA9 catalytic domain by stopped-flow CO2 hydration method
Drug: furosemide
Target: Carbonic anhydrase 12 (Enzyme)
Gene: CA12
UniProt: O43570 (CAH12_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.58
Assay: Inhibition of human recombinant CA12 catalytic domain by stopped-flow CO2 hydration method
Drug: furosemide
Target: Carbonic anhydrase 5A, mitochondrial (Enzyme)
Gene: CA5A
UniProt: P35218 (CAH5A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.3
Assay: Inhibition of human recombinant full length CA5A by stopped-flow CO2 hydration method
Drug: furosemide
Target: Carbonic anhydrase 5B, mitochondrial (Enzyme)
Gene: CA5B
UniProt: Q9Y2D0 (CAH5B_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.49
Assay: Inhibition of human recombinant full length CA5B by stopped-flow CO2 hydration method