AIM-Harvard/TrialPanorama-filtered huggingface dataset:
Drug: imipenem
Target: Bacterial penicillin-binding protein (Enzyme)
Gene: mrcA|mrcB|dacC|mrdA|ftsI|dacA|dacB
UniProt: P02918|P02919|P08506|P0AD65|P0AD68|P0AEB2|P24228 (PBPA_ECOLI|PBPB_ECOLI|DACC_ECOLI|PBP2_ECOLI|FTSI_ECOLI|DACA_ECOLI|DACB_ECOLI)
Organism: Escherichia coli (strain K12)
Action type: INHIBITOR
Assay: Mechanism of Action; CHEMBL2354204; PROTEIN FAMILY
Drug: imipramine
Target: D(2) dopamine receptor (GPCR)
Gene: DRD2
UniProt: P14416 (DRD2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.173
Drug: imipramine
Target: Sigma non-opioid intracellular receptor 1 (Membrane receptor)
Gene: SIGMAR1
UniProt: Q99720 (SGMR1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.284
Drug: imipramine
Target: Potassium voltage-gated channel subfamily H member 2 (Ion channel)
Gene: KCNH2
UniProt: Q12809 (KCNH2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.9
Drug: imipramine
Target: Sodium-dependent serotonin transporter (Transporter)
Gene: SLC6A4
UniProt: P31645 (SC6A4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.854
Action type: INHIBITOR
Drug: imipramine
Target: Sodium-dependent noradrenaline transporter (Transporter)
Gene: SLC6A2
UniProt: P23975 (SC6A2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.432
Action type: INHIBITOR
Drug: imipramine
Target: 5-hydroxytryptamine receptor 1A (GPCR)
Gene: HTR1A
UniProt: P08908 (5HT1A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.237
Drug: imipramine
Target: 5-hydroxytryptamine receptor 2A (GPCR)
Gene: HTR2A
UniProt: P28223 (5HT2A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.825
Drug: imipramine
Target: 5-hydroxytryptamine receptor 2C (GPCR)
Gene: HTR2C
UniProt: P28335 (5HT2C_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.796
Drug: imipramine
Target: Alpha-1A adrenergic receptor (GPCR)
Gene: ADRA1A
UniProt: P35348 (ADA1A_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7.495
Drug: imipramine
Target: Alpha-2B adrenergic receptor (GPCR)
Gene: ADRA2B
UniProt: P18089 (ADA2B_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7.1
Drug: imipramine
Target: D(3) dopamine receptor (GPCR)
Gene: DRD3
UniProt: P35462 (DRD3_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.412
Drug: imipramine
Target: Histamine H1 receptor (GPCR)
Gene: HRH1
UniProt: P35367 (HRH1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7.614
Drug: imipramine
Target: Muscarinic acetylcholine receptor M1 (GPCR)
Gene: CHRM1
UniProt: P11229 (ACM1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.377
Drug: imipramine
Target: Muscarinic acetylcholine receptor M2 (GPCR)
Gene: CHRM2
UniProt: P08172 (ACM2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.08
Drug: imipramine
Target: Muscarinic acetylcholine receptor M3 (GPCR)
Gene: CHRM3
UniProt: P20309 (ACM3_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.222
Drug: imipramine
Target: Muscarinic acetylcholine receptor M4 (GPCR)
Gene: CHRM4
UniProt: P08173 (ACM4_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.951
Drug: imipramine
Target: Muscarinic acetylcholine receptor M5 (GPCR)
Gene: CHRM5
UniProt: P08912 (ACM5_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.081
Drug: imipramine
Target: Sodium-dependent dopamine transporter (Transporter)
Gene: SLC6A3
UniProt: Q01959 (SC6A3_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.071
Drug: imipramine
Target: Adenosine receptor A3 (GPCR)
Gene: ADORA3
UniProt: P0DMS8 (AA3R_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 8.36
Assay: Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug: imipramine
Target: Major prion protein (Surface antigen)
Gene: PRNP
UniProt: P04156 (PRIO_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 5
Assay: Half maximal inhibition of Prion protein PrPsc formation was assayed in ScN2a cells
Drug: imipramine
Target: Solute carrier family 22 member 1 (Transporter)
Gene: SLC22A1
UniProt: O15245 (S22A1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.77
Assay: Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells by confocal microscopy
Drug: imipramine
Target: Potassium voltage-gated channel subfamily H member 1 (Ion channel)
Gene: KCNH1
UniProt: O95259 (KCNH1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.7
Action type: BLOCKER
Drug: imipramine
Target: Alpha-1A adrenergic receptor (GPCR)
Gene: Adra1a
UniProt: P43140 (ADA1A_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 8.77
Assay: Inhibition of binding of [3H]imipramine to imipramine receptor in rat brain
Drug: imipramine
Target: Sodium-dependent serotonin transporter (Transporter)
Gene: Slc6a4
UniProt: P31652 (SC6A4_RAT)
Organism: Rattus norvegicus
Activity: Ki = 7.38
Assay: Inhibition the uptake of tritiated serotonin (5-HT) by the serotonin transporter SERT in rat synaptosomes
Drug: imipramine
Target: Transporter (Transporter)
Gene: Slc6a2
UniProt: Q9WTR4 (Q9WTR4_RAT)
Organism: Rattus norvegicus
Activity: Ki = 7.92
Assay: Inhibition of uptake of tritiated norepinephrine (NE) in rat synaptosomes
Drug: imipramine
Target: Sodium-dependent dopamine transporter (Transporter)
Gene: Slc6a3
UniProt: Q61327 (SC6A3_MOUSE)
Organism: Mus musculus
Activity: Ki = 7.38
Assay: Tested in vitro for serotonin(5-HT) neuronal uptake inhibition
Drug: imipramine
Target: Sodium-dependent noradrenaline transporter (Transporter)
Gene: Slc6a2
UniProt: O55192 (SC6A2_MOUSE)
Organism: Mus musculus
Activity: Ki = 7.92
Assay: Tested in vitro for norepinephrine (NE) neuronal uptake inhibition
Drug: imipramine
Target: 5-hydroxytryptamine receptor 2C (GPCR)
Gene: Htr2c
UniProt: P34968 (5HT2C_MOUSE)
Organism: Mus musculus
Activity: Ki = 6.8
Assay: Binding affinity to 5-hydroxytryptamine 2C receptor using [3H]Mesulergine as radioligand in stably transfected NIH3T3 cells
Drug: imipramine
Target: D(2) dopamine receptor (GPCR)
Gene: Drd2
UniProt: P61168 (DRD2_MOUSE)
Organism: Mus musculus
Activity: Ki = 6.14
Assay: Binding affinity to Dopamine receptor D2 using [3H]spiperone as radioligand in stably transfected NIH3T3 cells
Drug: imipramine
Target: Sodium-dependent serotonin transporter (Transporter)
Gene: Slc6a4
UniProt: Q60857 (SC6A4_MOUSE)
Organism: Mus musculus
Activity: Ki = 8.3
Assay: Binding affinity to Serotonin transporter using [3H]-paroxetine as radioligand in stably transfected NIH3T3 cells
Drug: imipramine
Target: Histamine H1 receptor (GPCR)
Gene: Hrh1
UniProt: P31390 (HRH1_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 10.22
Assay: Compound tested for its inhibitory activity against Histamine H1 receptor
Drug: imipramine
Target: Muscarinic acetylcholine receptor M5 (GPCR)
Gene: Chrm5
UniProt: P08911 (ACM5_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 6.52
Assay: Binding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]quinuclidinyl benzilate (0.8 nM) in vitro to membranes of rat brain without cerebellum
Drug: imipramine
Target: Pleiotropic ABC efflux transporter of multiple drugs (Transporter)
Gene: PDR5
UniProt: P33302 (PDR5_YEAST)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Activity: IC50 = 4.66
Assay: Inhibition of Pdr5p-mediated rhodamine 6G transport in Saccharomyces cerevisiae MKPDR5h plasma membrane by spectrofluorometric assay
Drug: imipramine
Target: Solute carrier family 22 member 2 (Transporter)
Gene: SLC22A2
UniProt: O15244 (S22A2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.222
Drug: imipramine
Target: Glutamate NMDA receptor (Ion channel)
Gene: Grin1|Grin2a|Grin2b|Grin2c|Grin2d|Grin3b|Grin3a
UniProt: P35439|Q00959|Q00960|Q00961|Q62645|Q8VHN2|Q9R1M7 (NMDZ1_RAT|NMDE1_RAT|NMDE2_RAT|NMDE3_RAT|NMDE4_RAT|NMD3B_RAT|NMD3A_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 4.85
Assay: Inhibition of [3H]MK-801 binding to NMDA receptor of rat cerebral cortical synaptic membrane
Drug: imipramine
Target: Muscarinic acetylcholine receptor (GPCR)
Gene: Chrm1|Chrm3|Chrm4|Chrm5|Chrm2
UniProt: P08482|P08483|P08485|P08911|P10980 (ACM1_RAT|ACM3_RAT|ACM4_RAT|ACM5_RAT|ACM2_RAT)
Organism: Rattus norvegicus
Activity: Ki = 7.19
Assay: Binding affinity against Muscarinic acetylcholine receptor was determined in homogenized rat cortex tissue using [3H]N-methylscopolamine as radioligand
Drug: imipramine
Target: Serotonin (5-HT) receptor (GPCR)
Gene: Htr2c|Htr2a|Htr1a|Htr1b|Htr1d|Htr1f|Htr2b|Htr6|Htr7|Htr5a|Htr5b|Htr3a|Htr4|Htr3b
UniProt: P08909|P14842|P19327|P28564|P28565|P30940|P30994|P31388|P32305|P35364|P35365|P35563|Q62758|Q9JJ16 (5HT2C_RAT|5HT2A_RAT|5HT1A_RAT|5HT1B_RAT|5HT1D_RAT|5HT1F_RAT|5HT2B_RAT|5HT6R_RAT|5HT7R_RAT|5HT5A_RAT|5HT5B_RAT|5HT3A_RAT|5HT4R_RAT|5HT3B_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 7.36
Assay: Compound was tested for its inhibitory activity against 5-hydroxytryptamine receptor
Drug: imipramine
Target: Adrenergic receptor alpha-2 (GPCR)
Gene: Adra2b|Adra2c|Adra2a
UniProt: P19328|P22086|P22909 (ADA2B_RAT|ADA2C_RAT|ADA2A_RAT)
Organism: Rattus norvegicus
Activity: Ki = 6.59
Assay: In vitro binding affinity at Alpha-2 adrenergic receptor in rat cortex by radioligand binding assay using [3H]rauwolscine
Drug: imipramine
Target: Dopamine receptor (GPCR)
Gene: Drd1|Drd3|Drd5|Drd4|Drd2
UniProt: P18901|P19020|P25115|P30729|P61169 (DRD1_RAT|DRD3_RAT|DRD5_RAT|DRD4_RAT|DRD2_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 6.19
Assay: Concentration of compound for 50% displacement of [3H]spiperone from Dopamine receptor in rat brain
Drug: imipramine
Target: Adrenergic receptor alpha-1 (GPCR)
Gene: Adra1b|Adra1d|Adra1a
UniProt: P15823|P23944|P43140 (ADA1B_RAT|ADA1D_RAT|ADA1A_RAT)
Organism: Rattus norvegicus
Activity: Ki = 7.34
Assay: In vitro binding affinity at Alpha-1 adrenergic receptor by radioligand binding assay using [3H]prazosin
Drug: imipramine
Target: Sodium channel alpha subunits; brain (Types I, II, III) (Ion channel)
Gene: SCN1A|SCN2A|SCN3A
UniProt: P35498|Q99250|Q9NY46 (SCN1A_HUMAN|SCN2A_HUMAN|SCN3A_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.44
Assay: Inhibition of binding of Batrachotoxinin [3H]BTX-B to high affinity sites on voltage dependent sodium channels in a vesicular preparation from guinea pig cerebral cortex
Drug: imipramine
Target: Serotonin 2 (5-HT2) receptor (GPCR)
Gene: Htr2c|Htr2a|Htr2b
UniProt: P08909|P14842|P30994 (5HT2C_RAT|5HT2A_RAT|5HT2B_RAT)
Organism: Rattus norvegicus
Activity: Ki = 7.64
Assay: Binding affinity towards 5-hydroxytryptamine 2 receptor
Drug: imipramine
Target: G protein-activated inward rectifier potassium channel 4 (Ion channel)
Gene: Kcnj5
UniProt: P48545 (KCNJ5_MOUSE)
Organism: Mus musculus
Activity: EC50 = 4.5
Action type: BLOCKER
Drug: imipramine
Target: G protein-activated inward rectifier potassium channel 2 (Ion channel)
Gene: Kcnj6
UniProt: P48542 (KCNJ6_MOUSE)
Organism: Mus musculus
Activity: IC50 = 4.3
Action type: BLOCKER
Drug: imipramine
Target: Sphingomyelin phosphodiesterase (Enzyme)
Gene: SMPD1
UniProt: P17405 (ASM_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.3
Assay: Inhibition of mmLDL-stimulated acid sphingomyelinase in human PBMC lysates using 3H-sphingomyelin as substrate preincubated for 30 mins followed by mmLDL stimulation measured after 2 hrs by HPLC method
Drug: imiquimod
Target: Adenosine receptor A2a (GPCR)
Gene: ADORA2A
UniProt: P29274 (AA2AR_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.525
Assay: DRUGMATRIX: Adenosine A2A radioligand binding (ligand: AB-MECA)
Drug: imiquimod
Target: Histamine H2 receptor (GPCR)
Gene: HRH2
UniProt: P25021 (HRH2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.829
Assay: DRUGMATRIX: Histamine H2 radioligand binding (ligand: [125I] Aminopotentidine)
Drug: imiquimod
Target: Alpha-1D adrenergic receptor (GPCR)
Gene: ADRA1D
UniProt: P25100 (ADA1D_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.89
Assay: DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug: imiquimod
Target: Toll-like receptor 7 (Membrane receptor)
Gene: TLR7
UniProt: Q9NYK1 (TLR7_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 4.97
Action type: AGONIST
Assay: Agonist activity at human TLR-7 expressed in HEK293 cells after 24 hrs by SEAP reporter gene assay
Drug: incadronic acid
Target: Farnesyl pyrophosphate synthase (Enzyme)
UniProt: Q0GKD7 (Q0GKD7_LEIDO)
Organism: Leishmania donovani
Activity: IC50 = 6.8
Assay: Inhibitory activity against Leishmania major Farnesyl diphosphate synthase
Drug: incadronic acid
Target: Vacuolar-type proton translocating pyrophosphatase 1 (Unclassified)
Gene: PPase1
UniProt: Q8MTZ4 (Q8MTZ4_9TRYP)
Organism: Trypanosoma brucei
Activity: IC50 = 4.35
Assay: Inhibition of recombinant Trypanosoma brucei soluble vacuolar pyrophosphatase expressed in Escherichia coli
Drug: incadronic acid
Target: Farnesyl pyrophosphate synthase (Enzyme)
Gene: FDPS
UniProt: P14324 (FPPS_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7.523
Action type: INHIBITOR
Assay: inhibition of human recombinant FPP synthase
Drug: indalpine
Target: Sodium-dependent serotonin transporter (Transporter)
Gene: Slc6a4
UniProt: P31652 (SC6A4_RAT)
Organism: Rattus norvegicus
Activity: Ki = 8.7
Assay: Effect of compound on Serotonin transporter uptake from rat cortex using [3H]citalopram as radioligand
Drug: indapamide
Target: Carbonic anhydrase 2 (Enzyme)
Gene: CA2
UniProt: P00918 (CAH2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.7
Assay: Binding affinity to human recombinant carbonic anhydrase 2 by isothermal titration calorimetry assay
Drug: indapamide
Target: Solute carrier family 12 member 3 (Transporter)
Gene: SLC12A3
UniProt: P55017 (S12A3_HUMAN)
Organism: Homo sapiens
Activity: A2 = 7.54
Action type: INHIBITOR
Drug: indapamide
Target: Carbonic anhydrase 1 (Enzyme)
Gene: CA1
UniProt: P00915 (CAH1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5
Assay: Binding affinity to human recombinant carbonic anhydrase 1 by thermal shift assay
Drug: indapamide
Target: Carbonic anhydrase 4 (Enzyme)
Gene: CA4
UniProt: P22748 (CAH4_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.67
Assay: Inhibition of human recombinant full length CA4 by stopped-flow CO2 hydration method
Drug: indapamide
Target: Carbonic anhydrase 9 (Enzyme)
Gene: CA9
UniProt: Q16790 (CAH9_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.44
Assay: Inhibition of human recombinant CA9 catalytic domain by stopped-flow CO2 hydration method
Drug: indapamide
Target: Carbonic anhydrase 12 (Enzyme)
Gene: CA12
UniProt: O43570 (CAH12_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8
Assay: Inhibition of human recombinant CA12 catalytic domain by stopped-flow CO2 hydration method
Drug: indapamide
Target: Potassium voltage-gated channel subfamily KQT member 1 (Ion channel)
Gene: KCNQ1
UniProt: P51787 (KCNQ1_HUMAN)
Organism: Homo sapiens
Drug: indapamide
Target: Carbonic anhydrase 5A, mitochondrial (Enzyme)
Gene: CA5A
UniProt: P35218 (CAH5A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.05
Assay: Inhibition of human recombinant full length CA5A by stopped-flow CO2 hydration method
Drug: indapamide
Target: Carbonic anhydrase 5B, mitochondrial (Enzyme)
Gene: CA5B
UniProt: Q9Y2D0 (CAH5B_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.56
Assay: Inhibition of human recombinant full length CA5B by stopped-flow CO2 hydration method
Drug: indapamide
Target: Carbonic anhydrase 7 (Enzyme)
Gene: CA7
UniProt: P43166 (CAH7_HUMAN)
Organism: Homo sapiens
Activity: Ki = 9.64
Assay: Inhibition of human recombinant full length CA7 by stopped-flow CO2 hydration method
Drug: indapamide
Target: Carbonic anhydrase 6 (Enzyme)
Gene: CA6
UniProt: P23280 (CAH6_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.6
Assay: Binding affinity to human recombinant carbonic anhydrase 6 expressed in Escherichia coli Rosetta2 (DE3) by thermal shift assay
Drug: indapamide
Target: Carbonic anhydrase 14 (Enzyme)
Gene: CA14
UniProt: Q9ULX7 (CAH14_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.31
Assay: Inhibition of human recombinant full length CA14 by stopped-flow CO2 hydration method
Drug: indapamide
Target: Arachidonate 15-lipoxygenase (Enzyme)
Gene: ALOX15
UniProt: P12530 (LOX15_RABIT)
Organism: Oryctolagus cuniculus
Activity: IC50 = 5.535
Assay: DRUGMATRIX: Lipoxygenase 15-LO enzyme inhibition (substrate: Linoleic acid)
Drug: indapamide
Target: Carbonic anhydrase 13 (Enzyme)
Gene: Ca13
UniProt: Q9D6N1 (CAH13_MOUSE)
Organism: Mus musculus
Activity: Ki = 7.89
Assay: Inhibition of mouse recombinant full length CA13 by stopped-flow CO2 hydration method
Drug: indapamide
Target: Carbonic anhydrase 13 (Enzyme)
Gene: CA13
UniProt: Q8N1Q1 (CAH13_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7
Assay: Binding affinity to human recombinant carbonic anhydrase 13 by thermal shift assay
Drug: indecainide
Target: Sodium channel protein type 5 subunit alpha (Ion channel)
Gene: SCN5A
UniProt: Q14524 (SCN5A_HUMAN)
Organism: Homo sapiens
Action type: BLOCKER
Drug: indenolol
Target: Beta-1 adrenergic receptor (GPCR)
Gene: ADRB1
UniProt: P08588 (ADRB1_HUMAN)
Organism: Homo sapiens
Drug: indenolol
Target: Beta-2 adrenergic receptor (GPCR)
Gene: ADRB2
UniProt: P07550 (ADRB2_HUMAN)
Organism: Homo sapiens
Drug: indinavir
Target: Cytochrome P450 3A4 (Enzyme)
Gene: CYP3A4
UniProt: P08684 (CP3A4_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.398
Assay: DRUGMATRIX: CYP450, 3A4 enzyme inhibition (substrate: 7-Benzyloxy-4-(trifluoromethyl)-coumarin)
Drug: indinavir
Target: Gag-Pol polyprotein (Polyprotein)
Gene: gag-pol
UniProt: P03367 (POL_HV1BR)
Organism: Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI)
Activity: IC50 = 9.222
Drug: indinavir
Target: Thromboxane-A synthase (Enzyme)
Gene: TBXAS1
UniProt: P24557 (THAS_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.733
Assay: DRUGMATRIX: Thromboxane Synthetase enzyme inhibition (substrate: PGH2)
Drug: indinavir
Target: Substance-K receptor (GPCR)
Gene: TACR2
UniProt: P21452 (NK2R_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.77
Assay: DRUGMATRIX: Tachykinin NK2  radioligand binding (ligand: [3H] SR-48968)
Drug: indinavir
Target: Pol polyprotein (Enzyme)
Gene: pol
UniProt: Q72874 (Q72874_9HIV1)
Organism: Human immunodeficiency virus 1
Activity: Ki = 10.15
Action type: INHIBITOR
Assay: Inhibition of HIV-1 Protease activity
Drug: indinavir
Target: Protease (Enzyme)
Gene: protease
UniProt: Q4U254 (Q4U254_9ENTO)
Organism: Human rhinovirus sp
Activity: Ki = 8.48
Assay: Binding affinity against HIV-2 protease enzyme.
Drug: indinavir
Target: Multidrug and toxin extrusion protein 1 (Transporter)
Gene: SLC47A1
UniProt: Q96FL8 (S47A1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.77
Assay: Inhibition of human MATE1-mediated [14]-metformin uptake expressed in HEK293 cells after 1.5 mins by scintillation counting analysis
Drug: indinavir
Target: Multidrug and toxin extrusion protein 2 (Transporter)
Gene: SLC47A2
UniProt: Q86VL8 (S47A2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.11
Assay: Inhibition of human MATE2K-mediated ASP+ uptake expressed in HEK293 cells up to 500 uM after 1.5 mins by fluorescence assay
Drug: indinavir
Target: Protease (Enzyme)
Gene: protease
UniProt: Q9YQ12 (Q9YQ12_9HIV1)
Organism: Human immunodeficiency virus 1
Activity: Ki = 9.27
Drug: indinavir
Target: Protease (Unclassified)
Gene: HIV-1 protease
UniProt: O90781 (O90781_9PLVG)
Organism: Human immunodeficiency virus
Activity: Ki = 9.06
Assay: Inhibition of HIV1 recombinant protease D30N/N88D mutant expressed in Escherichia coli by spectrophotometric assay
Drug: indinavir
Target: Protease (Unclassified)
Gene: HIV-1 protease
UniProt: Q9YQ30 (Q9YQ30_9PLVG)
Organism: Human immunodeficiency virus
Activity: Ki = 9.42
Assay: Inhibition of recombinant HIV protease expressed in inclusion bodies of Escherichia coli BL21 (DE3)
Drug: indisetron
Target: 5-hydroxytryptamine receptor 3A (Ion channel)
Gene: HTR3A
UniProt: P46098 (5HT3A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.74
Action type: ANTAGONIST
Drug: indobufen
Target: Prostaglandin G/H synthase 2 (Enzyme)
Gene: PTGS2
UniProt: P35354 (PGH2_HUMAN)
Organism: Homo sapiens
Drug: indobufen
Target: Prostaglandin G/H synthase 1 (Enzyme)
Gene: PTGS1
UniProt: P23219 (PGH1_HUMAN)
Organism: Homo sapiens
Drug: indomethacin
Target: Prostaglandin G/H synthase 2 (Enzyme)
Gene: PTGS2
UniProt: P35354 (PGH2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.33
Action type: INHIBITOR
Drug: indomethacin
Target: Prostaglandin G/H synthase 1 (Enzyme)
Gene: PTGS1
UniProt: P23219 (PGH1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7.21
Action type: INHIBITOR
Drug: indomethacin
Target: Multidrug resistance protein 1 (Transporter)
Gene: ABCB1
UniProt: P08183 (MDR1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.49
Drug: indomethacin
Target: Multidrug resistance-associated protein 1 (Transporter)
Gene: ABCC1
UniProt: P33527 (MRP1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.92
Assay: Inhibition of human MRP1 in human 2008 cells
Drug: indomethacin
Target: Androgen receptor (Nuclear hormone receptor)
Gene: AR
UniProt: P10275 (ANDR_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 9.85
Assay: Agonist activity at androgen receptor (unknown origin) expressed in HeLa cells co-expressing PSA-(ARE)4-Luc13 assessed as induction of DHT-induced luciferase activity after 20 mins by luciferase reporter gene assay
Drug: indomethacin
Target: Prostaglandin D2 receptor 2 (GPCR)
Gene: PTGDR2
UniProt: Q9Y5Y4 (PD2R2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.53
Drug: indomethacin
Target: Dehydrogenase/reductase SDR family member 9 (Enzyme)
Gene: DHRS9
UniProt: Q9BPW9 (DHRS9_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.85
Assay: Inhibition of 3alphaHSD
Drug: indomethacin
Target: Aldose reductase (Enzyme)
Gene: AKR1B1
UniProt: P15121 (ALDR_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.22
Assay: In vitro inhibition of rabbit lens aldose reductase.
Drug: indomethacin
Target: Aldo-keto reductase family 1 member C2 (Enzyme)
Gene: AKR1C2
UniProt: P52895 (AK1C2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.44
Assay: Inhibition of human recombinant AKR1C2-mediated NADP+-dependent oxidation of S-(+)-1,2,3,4-tetrahydro-1-naphthol
Drug: indomethacin
Target: Aldo-keto reductase family 1 member C3 (Enzyme)
Gene: AKR1C3
UniProt: P42330 (AK1C3_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7
Assay: Inhibition of human recombinant AKR1C3-mediated NADP+-dependent oxidation of S-(+)-1,2,3,4-tetrahydro-1-naphthol
Drug: indomethacin
Target: Peroxisome proliferator-activated receptor gamma (Nuclear hormone receptor)
Gene: PPARG
UniProt: P37231 (PPARG_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.38
Action type: AGONIST
Drug: indomethacin
Target: Prostaglandin E2 receptor EP2 subtype (GPCR)
Gene: PTGER2
UniProt: P43116 (PE2R2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.691
Drug: indomethacin
Target: Lactoylglutathione lyase (Enzyme)
Gene: GLO1
UniProt: Q04760 (LGUL_HUMAN)
Organism: Homo sapiens
Activity: Ki = 4.74
Assay: Inhibition of glyoxalase 1
Drug: indomethacin
Target: Cytochrome c oxidase subunit 2 (Enzyme)
Gene: MT-CO2
UniProt: P00403 (COX2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.21
Assay: Inhibition of human COX2 assessed as reduction in PGF2alpha production by ELISA
Drug: indomethacin
Target: Interleukin-8 (Cytokine)
Gene: CXCL8
UniProt: P10145 (IL8_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7.3
Assay: Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay
Drug: indomethacin
Target: Potassium voltage-gated channel subfamily A member 7 (Ion channel)
Gene: KCNA7
UniProt: Q96RP8 (KCNA7_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.5
Drug: indomethacin
Target: Aldose reductase (Enzyme)
Gene: Akr1b1
UniProt: P07943 (ALDR_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 5.44
Assay: DRUGMATRIX: Aldose Reductase enzyme inhibition (substrate: DL-Glyceraldehyde)
Drug: indomethacin
Target: Prostaglandin G/H synthase 2 (Enzyme)
Gene: Ptgs2
UniProt: Q05769 (PGH2_MOUSE)
Organism: Mus musculus
Activity: IC50 = 8.19
Assay: IC50 value was determined against Prostaglandin G/H synthase 2 of J7744A.1 cell lines.
Drug: indomethacin
Target: Prostaglandin G/H synthase 1 (Enzyme)
Gene: Ptgs1
UniProt: P22437 (PGH1_MOUSE)
Organism: Mus musculus
Activity: IC50 = 8.7
Assay: In vitro inhibitory activity against Prostaglandin G/H synthase 1 in murine J774 cells
Drug: indomethacin
Target: Aldose reductase (Enzyme)
Gene: AKR1B1
UniProt: P16116 (ALDR_BOVIN)
Organism: Bos taurus
Activity: IC50 = 5.3
Assay: Inhibition of Aldose reductase (AR)