AIM-Harvard/TrialPanorama-filtered huggingface dataset:
Drug: midostaurin
Target: Calcium/calmodulin-dependent protein kinase kinase 2 (Kinase)
Gene: CAMKK2
UniProt: Q96RR4 (KKCC2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.14
Assay: Binding constant for CAMKK2 kinase domain
Drug: midostaurin
Target: MAP/microtubule affinity-regulating kinase 3 (Kinase)
Gene: MARK3
UniProt: P27448 (MARK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.68
Assay: Binding constant for full-length MARK3
Drug: midostaurin
Target: Calcium/calmodulin-dependent protein kinase kinase 1 (Kinase)
Gene: CAMKK1
UniProt: Q8N5S9 (KKCC1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.89
Assay: Binding constant for CAMKK1 kinase domain
Drug: midostaurin
Target: Calcium/calmodulin-dependent protein kinase type 1G (Kinase)
Gene: CAMK1G
UniProt: Q96NX5 (KCC1G_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.75
Assay: Binding constant for CAMK1G kinase domain
Drug: midostaurin
Target: Epithelial discoidin domain-containing receptor 1 (Kinase)
Gene: DDR1
UniProt: Q08345 (DDR1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.14
Assay: Binding constant for DDR1 kinase domain
Drug: midostaurin
Target: Testis-specific serine/threonine-protein kinase 1 (Kinase)
Gene: TSSK1B
UniProt: Q9BXA7 (TSSK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.32
Assay: Binding constant for full-length TSSK1
Drug: midostaurin
Target: Inhibitor of nuclear factor kappa-B kinase subunit beta (Kinase)
Gene: IKBKB
UniProt: O14920 (IKKB_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.2
Assay: Binding constant for IKK-beta kinase domain
Drug: midostaurin
Target: 3-phosphoinositide-dependent protein kinase 1 (Kinase)
Gene: PDPK1
UniProt: O15530 (PDPK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.96
Assay: Binding affinity to PDPK1
Drug: midostaurin
Target: Tyrosine-protein kinase ZAP-70 (Kinase)
Gene: ZAP70
UniProt: P43403 (ZAP70_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.59
Assay: Binding constant for ZAP70 kinase domain
Drug: midostaurin
Target: Glycogen synthase kinase-3 alpha (Kinase)
Gene: GSK3A
UniProt: P49840 (GSK3A_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.6
Assay: Binding constant for full-length GSK3A
Drug: midostaurin
Target: Tyrosine-protein kinase receptor UFO (Kinase)
Gene: AXL
UniProt: P30530 (UFO_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.21
Assay: Binding constant for AXL kinase domain
Drug: midostaurin
Target: BDNF/NT-3 growth factors receptor (Kinase)
Gene: NTRK2
UniProt: Q16620 (NTRK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.51
Assay: Binding constant for TRKB kinase domain
Drug: midostaurin
Target: Tyrosine-protein kinase receptor TYRO3 (Kinase)
Gene: TYRO3
UniProt: Q06418 (TYRO3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.06
Assay: Inhibition of SKY (unknown origin)
Drug: midostaurin
Target: Ribosomal protein S6 kinase beta-1 (Kinase)
Gene: RPS6KB1
UniProt: P23443 (KS6B1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.89
Assay: Binding constant for S6K1 kinase domain
Drug: midostaurin
Target: Serine/threonine-protein kinase N2 (Kinase)
Gene: PKN2
UniProt: Q16513 (PKN2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.82
Assay: Binding constant for PKN2 kinase domain
Drug: midostaurin
Target: RAC-beta serine/threonine-protein kinase (Kinase)
Gene: AKT2
UniProt: P31751 (AKT2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.11
Assay: Binding constant for AKT2 kinase domain
Drug: midostaurin
Target: Serine/threonine-protein kinase 3 (Kinase)
Gene: STK3
UniProt: Q13188 (STK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.4
Assay: Binding affinity to MST2
Drug: midostaurin
Target: Ribosomal protein S6 kinase alpha-6 (Kinase)
Gene: RPS6KA6
UniProt: Q9UK32 (KS6A6_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.82
Assay: Binding constant for RPS6KA6(Kin.Dom.1 - C-terminal) kinase domain
Drug: midostaurin
Target: NUAK family SNF1-like kinase 2 (Kinase)
Gene: NUAK2
UniProt: Q9H093 (NUAK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.2
Assay: Binding constant for SNARK kinase domain
Drug: midostaurin
Target: Non-receptor tyrosine-protein kinase TNK1 (Kinase)
Gene: TNK1
UniProt: Q13470 (TNK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.08
Assay: Binding constant for full-length TNK1
Drug: midostaurin
Target: Non-receptor tyrosine-protein kinase TYK2 (Kinase)
Gene: TYK2
UniProt: P29597 (TYK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.6
Assay: Binding constant for TYK2(Kin.Dom.2/JH1 - catalytic) kinase domain
Drug: midostaurin
Target: Serine/threonine-protein kinase Chk1 (Kinase)
Gene: CHEK1
UniProt: O14757 (CHK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.89
Assay: Binding constant for CHEK1 kinase domain
Drug: midostaurin
Target: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Kinase)
Gene: PIK3CA
UniProt: P42336 (PK3CA_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.96
Assay: Binding constant for PIK3CA(H1047L) kinase domain
Drug: midostaurin
Target: Serine/threonine-protein kinase PAK 3 (Kinase)
Gene: PAK3
UniProt: O75914 (PAK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.75
Assay: Binding constant for full-length PAK3
Drug: midostaurin
Target: Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (Kinase)
Gene: PIP5K1A
UniProt: Q99755 (PI51A_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.51
Assay: Binding constant for full-length PIP5K1A
Drug: midostaurin
Target: Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (Kinase)
Gene: PIP4K2B
UniProt: P78356 (PI42B_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.57
Assay: Binding constant for full-length PIP5K2B
Drug: midostaurin
Target: Myosin light chain kinase family member 4 (Kinase)
Gene: MYLK4
UniProt: Q86YV6 (MYLK4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.19
Assay: Binding constant for SgK085 kinase domain
Drug: midostaurin
Target: Wee1-like protein kinase (Kinase)
Gene: WEE1
UniProt: P30291 (WEE1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.34
Assay: Binding constant for WEE1 kinase domain
Drug: midostaurin
Target: Serine/threonine-protein kinase 25 (Kinase)
Gene: STK25
UniProt: O00506 (STK25_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.75
Assay: Binding constant for YSK1 kinase domain
Drug: midostaurin
Target: Protein-tyrosine kinase 2-beta (Kinase)
Gene: PTK2B
UniProt: Q14289 (FAK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.18
Assay: Binding constant for full-length PTK2B
Drug: midostaurin
Target: Serine/threonine-protein kinase RIO1 (Kinase)
Gene: RIOK1
UniProt: Q9BRS2 (RIOK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.92
Assay: Binding constant for full-length RIOK1
Drug: midostaurin
Target: Tyrosine-protein kinase receptor Tie-1 (Kinase)
Gene: TIE1
UniProt: P35590 (TIE1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.85
Assay: Binding constant for TIE1 kinase domain
Drug: midostaurin
Target: NT-3 growth factor receptor (Kinase)
Gene: NTRK3
UniProt: Q16288 (NTRK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.77
Assay: Binding constant for TRKC kinase domain
Drug: midostaurin
Target: Casein kinase II subunit alpha (Kinase)
Gene: CSNK2A1
UniProt: P68400 (CSK21_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.6
Assay: Binding constant for full-length CSNK2A1
Drug: midostaurin
Target: Dual specificity tyrosine-phosphorylation-regulated kinase 1B (Kinase)
Gene: DYRK1B
UniProt: Q9Y463 (DYR1B_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.48
Assay: Binding constant for full-length DYRK1B
Drug: midostaurin
Target: Inhibitor of nuclear factor kappa-B kinase subunit epsilon (Kinase)
Gene: IKBKE
UniProt: Q14164 (IKKE_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.8
Assay: Binding constant for full-length IKK-epsilon
Drug: midostaurin
Target: Serine/threonine-protein kinase STK11 (Kinase)
Gene: STK11
UniProt: Q15831 (STK11_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.46
Assay: Binding constant for full-length LKB1
Drug: midostaurin
Target: Dual specificity mitogen-activated protein kinase kinase 3 (Kinase)
Gene: MAP2K3
UniProt: P46734 (MP2K3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.28
Assay: Binding constant for full-length MEK3
Drug: midostaurin
Target: Maternal embryonic leucine zipper kinase (Kinase)
Gene: MELK
UniProt: Q14680 (MELK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.55
Assay: Binding constant for full-length MELK
Drug: midostaurin
Target: Eukaryotic translation initiation factor 2-alpha kinase 4 (Kinase)
Gene: EIF2AK4
UniProt: Q9P2K8 (E2AK4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.41
Assay: Binding constant for GCN2(Kin.Dom.2,S808G) kinase domain
Drug: midostaurin
Target: Interleukin-1 receptor-associated kinase 3 (Kinase)
Gene: IRAK3
UniProt: Q9Y616 (IRAK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.75
Assay: Binding constant for IRAK3 kinase domain
Drug: midostaurin
Target: Serine/threonine-protein kinase RIO3 (Kinase)
Gene: RIOK3
UniProt: O14730 (RIOK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.38
Assay: Binding constant for full-length RIOK3
Drug: midostaurin
Target: Serine/threonine-protein kinase SIK2 (Kinase)
Gene: SIK2
UniProt: Q9H0K1 (SIK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.25
Assay: Binding constant for full-length SNF1LK2
Drug: midostaurin
Target: SRSF protein kinase 1 (Kinase)
Gene: SRPK1
UniProt: Q96SB4 (SRPK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.38
Assay: Binding constant for full-length SRPK1
Drug: midostaurin
Target: SRSF protein kinase 2 (Kinase)
Gene: SRPK2
UniProt: P78362 (SRPK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.48
Assay: Binding constant for full-length SRPK2
Drug: midostaurin
Target: Serine/threonine-protein kinase 33 (Kinase)
Gene: STK33
UniProt: Q9BYT3 (STK33_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.72
Assay: Binding constant for STK33 kinase domain
Drug: midostaurin
Target: 5'-AMP-activated protein kinase catalytic subunit alpha-2 (Kinase)
Gene: PRKAA2
UniProt: P54646 (AAPK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.34
Assay: Binding constant for AMPK-alpha2 kinase domain
Drug: midostaurin
Target: Myotonin-protein kinase (Kinase)
Gene: DMPK
UniProt: Q09013 (DMPK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.42
Assay: Binding constant for DMPK kinase domain
Drug: midostaurin
Target: RAC-gamma serine/threonine-protein kinase (Kinase)
Gene: AKT3
UniProt: Q9Y243 (AKT3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.36
Assay: Binding constant for AKT3 kinase domain
Drug: midostaurin
Target: Serine/threonine-protein kinase LATS1 (Kinase)
Gene: LATS1
UniProt: O95835 (LATS1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.96
Assay: Binding constant for LATS1 kinase domain
Drug: midostaurin
Target: Serine/threonine-protein kinase LATS2 (Kinase)
Gene: LATS2
UniProt: Q9NRM7 (LATS2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.66
Assay: Binding constant for LATS2 kinase domain
Drug: midostaurin
Target: Leukocyte tyrosine kinase receptor (Kinase)
Gene: LTK
UniProt: P29376 (LTK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.52
Assay: Binding constant for LTK kinase domain
Drug: midostaurin
Target: Mitogen-activated protein kinase kinase kinase kinase 1 (Kinase)
Gene: MAP4K1
UniProt: Q92918 (M4K1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.68
Assay: Binding constant for MAP4K1 kinase domain
Drug: midostaurin
Target: NUAK family SNF1-like kinase 1 (Kinase)
Gene: NUAK1
UniProt: O60285 (NUAK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.39
Assay: Binding constant for ARK5 kinase domain
Drug: midostaurin
Target: Serine/threonine-protein kinase pim-3 (Kinase)
Gene: PIM3
UniProt: Q86V86 (PIM3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.25
Assay: Binding constant for PIM3 kinase domain
Drug: midostaurin
Target: cAMP-dependent protein kinase catalytic subunit alpha (Kinase)
Gene: PRKACA
UniProt: P17612 (KAPCA_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.14
Assay: Binding constant for PKAC-alpha kinase domain
Drug: midostaurin
Target: Mitogen-activated protein kinase kinase kinase kinase 3 (Kinase)
Gene: MAP4K3
UniProt: Q8IVH8 (M4K3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.92
Assay: Binding constant for MAP4K3 kinase domain
Drug: midostaurin
Target: Aurora kinase B (Kinase)
Gene: AURKB
UniProt: Q96GD4 (AURKB_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.21
Assay: Binding constant for AURKB kinase domain
Drug: midostaurin
Target: Tyrosine-protein kinase Blk (Kinase)
Gene: BLK
UniProt: P51451 (BLK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.3
Assay: Binding constant for BLK kinase domain
Drug: midostaurin
Target: Serine/threonine-protein kinase BRSK1 (Kinase)
Gene: BRSK1
UniProt: Q8TDC3 (BRSK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.92
Assay: Binding constant for BRSK1 kinase domain
Drug: midostaurin
Target: Mitogen-activated protein kinase kinase kinase kinase 4 (Kinase)
Gene: MAP4K4
UniProt: O95819 (M4K4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.19
Assay: Binding constant for MAP4K4 kinase domain
Drug: midostaurin
Target: Serine/threonine-protein kinase MARK1 (Kinase)
Gene: MARK1
UniProt: Q9P0L2 (MARK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.77
Assay: Binding constant for MARK1 kinase domain
Drug: midostaurin
Target: MAP/microtubule affinity-regulating kinase 4 (Kinase)
Gene: MARK4
UniProt: Q96L34 (MARK4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.43
Assay: Binding constant for MARK4 kinase domain
Drug: midostaurin
Target: Dual specificity mitogen-activated protein kinase kinase 4 (Kinase)
Gene: MAP2K4
UniProt: P45985 (MP2K4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.32
Assay: Binding constant for MEK4 kinase domain
Drug: midostaurin
Target: Dual specificity mitogen-activated protein kinase kinase 6 (Kinase)
Gene: MAP2K6
UniProt: P52564 (MP2K6_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.19
Assay: Binding constant for MEK6 kinase domain
Drug: midostaurin
Target: Tyrosine-protein kinase Mer (Kinase)
Gene: MERTK
UniProt: Q12866 (MERTK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.54
Assay: Binding constant for MERTK kinase domain
Drug: midostaurin
Target: Cyclin-dependent kinase 19 (Kinase)
Gene: CDK19
UniProt: Q9BWU1 (CDK19_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.14
Assay: Binding constant for CDK11 kinase domain
Drug: midostaurin
Target: Mitogen-activated protein kinase kinase kinase 9 (Kinase)
Gene: MAP3K9
UniProt: P80192 (M3K9_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.82
Assay: Binding constant for MLK1 kinase domain
Drug: midostaurin
Target: Mitogen-activated protein kinase kinase kinase 10 (Kinase)
Gene: MAP3K10
UniProt: Q02779 (M3K10_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.1
Assay: Binding constant for MLK2 kinase domain
Drug: midostaurin
Target: Mitogen-activated protein kinase kinase kinase 11 (Kinase)
Gene: MAP3K11
UniProt: Q16584 (M3K11_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.77
Assay: Binding constant for MLK3 kinase domain
Drug: midostaurin
Target: Death-associated protein kinase 1 (Kinase)
Gene: DAPK1
UniProt: P53355 (DAPK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.33
Assay: Binding constant for DAPK1 kinase domain
Drug: midostaurin
Target: Serine/threonine-protein kinase PAK 1 (Kinase)
Gene: PAK1
UniProt: Q13153 (PAK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.7
Assay: Binding affinity to PAK1
Drug: midostaurin
Target: Serine/threonine-protein kinase PAK 2 (Kinase)
Gene: PAK2
UniProt: Q13177 (PAK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.68
Assay: Binding affinity to PAK2
Drug: midostaurin
Target: Serine/threonine-protein kinase BRSK2 (Kinase)
Gene: BRSK2
UniProt: Q8IWQ3 (BRSK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.19
Assay: Binding constant for full-length BRSK2
Drug: midostaurin
Target: Serine/threonine-protein kinase SIK1 (Kinase)
Gene: SIK1
UniProt: P57059 (SIK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.8
Assay: Binding constant for SNF1LK kinase domain
Drug: midostaurin
Target: Tubulin alpha-1A chain (Structural)
Gene: Tuba1a
UniProt: P68370 (TBA1A_RAT)
Organism: Rattus norvegicus
Activity: Kd = 5.51
Assay: Binding constant for ERBB4 kinase domain
Drug: midostaurin
Target: Serine/threonine-protein kinase D2 (Kinase)
Gene: PRKD2
UniProt: Q9BZL6 (KPCD2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.2
Assay: Binding constant for PRKD2 kinase domain
Drug: midostaurin
Target: Serine/threonine-protein kinase D3 (Kinase)
Gene: PRKD3
UniProt: O94806 (KPCD3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.5
Assay: Binding constant for PRKD3 kinase domain
Drug: midostaurin
Target: cGMP-dependent protein kinase 2 (Kinase)
Gene: PRKG2
UniProt: Q13237 (KGP2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.13
Assay: Binding constant for PRKG2 kinase domain
Drug: midostaurin
Target: Interferon-induced, double-stranded RNA-activated protein kinase (Kinase)
Gene: EIF2AK2
UniProt: P19525 (E2AK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.16
Assay: Binding constant for PRKR kinase domain
Drug: midostaurin
Target: Proto-oncogene tyrosine-protein kinase ROS (Kinase)
Gene: ROS1
UniProt: P08922 (ROS1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.37
Assay: Binding constant for ROS1 kinase domain
Drug: midostaurin
Target: Ribosomal protein S6 kinase alpha-1 (Kinase)
Gene: RPS6KA1
UniProt: Q15418 (KS6A1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.59
Assay: Binding affinity to RPS6KA4(Kin.Dom.1-N-terminal)
Drug: midostaurin
Target: Ribosomal protein S6 kinase alpha-4 (Kinase)
Gene: RPS6KA4
UniProt: O75676 (KS6A4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.59
Assay: Binding constant for RPS6KA4(Kin.Dom.1 - C-terminal) kinase domain
Drug: midostaurin
Target: Mitogen-activated protein kinase kinase kinase kinase 2 (Kinase)
Gene: MAP4K2
UniProt: Q12851 (M4K2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.6
Assay: Binding affinity to MAP4K2
Drug: midostaurin
Target: Misshapen-like kinase 1 (Kinase)
Gene: MINK1
UniProt: Q8N4C8 (MINK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.77
Assay: Binding affinity to MINK
Drug: midostaurin
Target: Serine/threonine-protein kinase TBK1 (Kinase)
Gene: TBK1
UniProt: Q9UHD2 (TBK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.03
Assay: Binding affinity to TBK1
Drug: midostaurin
Target: Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Kinase)
Gene: DYRK1A
UniProt: Q13627 (DYR1A_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7
Assay: Binding affinity to DYRK1A
Drug: midostaurin
Target: Ephrin type-B receptor 6 (Kinase)
Gene: EPHB6
UniProt: O15197 (EPHB6_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.51
Assay: Binding affinity to EPHB6
Drug: midostaurin
Target: Serine/threonine-protein kinase/endoribonuclease IRE1 (Kinase)
Gene: ERN1
UniProt: O75460 (ERN1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.64
Assay: Binding affinity to ERN1
Drug: midostaurin
Target: Rhodopsin kinase (Kinase)
Gene: GRK1
UniProt: Q15835 (RK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.07
Assay: Binding affinity to GRK1
Drug: midostaurin
Target: G protein-coupled receptor kinase 4 (Kinase)
Gene: GRK4
UniProt: P32298 (GRK4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.96
Assay: Binding affinity to GRK4
Drug: midostaurin
Target: G protein-coupled receptor kinase 7 (Kinase)
Gene: GRK7
UniProt: Q8WTQ7 (GRK7_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.32
Assay: Binding affinity to GRK7
Drug: midostaurin
Target: Homeodomain-interacting protein kinase 2 (Kinase)
Gene: HIPK2
UniProt: Q9H2X6 (HIPK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.51
Assay: Binding affinity to HIPK2
Drug: midostaurin
Target: Homeodomain-interacting protein kinase 3 (Kinase)
Gene: HIPK3
UniProt: Q9H422 (HIPK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.64
Assay: Binding affinity to HIPK3
Drug: midostaurin
Target: Homeodomain-interacting protein kinase 4 (Kinase)
Gene: HIPK4
UniProt: Q8NE63 (HIPK4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.02
Assay: Binding affinity to HIPK4
Drug: midostaurin
Target: Hormonally up-regulated neu tumor-associated kinase (Kinase)
Gene: HUNK
UniProt: P57058 (HUNK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.62
Assay: Binding affinity to HUNK
Drug: midostaurin
Target: Serine/threonine-protein kinase ICK (Kinase)
Gene: ICK
UniProt: Q9UPZ9 (ICK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.23
Assay: Binding constant for ICK kinase domain
Drug: midostaurin
Target: Inhibitor of nuclear factor kappa-B kinase subunit alpha (Kinase)
Gene: CHUK
UniProt: O15111 (IKKA_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.42
Assay: Binding affinity to IKK-alpha
Drug: midostaurin
Target: Mitogen-activated protein kinase kinase kinase 13 (Kinase)
Gene: MAP3K13
UniProt: O43283 (M3K13_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.55
Assay: Binding affinity to LZK
Drug: midostaurin
Target: Mitogen-activated protein kinase kinase kinase 2 (Kinase)
Gene: MAP3K2
UniProt: Q9Y2U5 (M3K2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.85
Assay: Binding affinity to MAP3K2
Drug: midostaurin
Target: Mitogen-activated protein kinase kinase kinase 3 (Kinase)
Gene: MAP3K3
UniProt: Q99759 (M3K3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.68
Assay: Binding affinity to MAP3K3
Drug: midostaurin
Target: Microtubule-associated serine/threonine-protein kinase 1 (Kinase)
Gene: MAST1
UniProt: Q9Y2H9 (MAST1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.72
Assay: Binding constant for MAST1 kinase domain
Drug: midostaurin
Target: U4/U6 small nuclear ribonucleoprotein Prp4 (Nuclear other)
Gene: PRPF4
UniProt: O43172 (PRP4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.26
Assay: Binding affinity to PRP4
Drug: midostaurin
Target: Serine/threonine-protein kinase RIO2 (Kinase)
Gene: RIOK2
UniProt: Q9BVS4 (RIOK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.01
Assay: Binding affinity to RIOK2
Drug: midostaurin
Target: SRSF protein kinase 3 (Kinase)
Gene: SRPK3
UniProt: Q9UPE1 (SRPK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.1
Assay: Binding affinity to SRPK3
Drug: midostaurin
Target: Mitogen-activated protein kinase kinase kinase 7 (Kinase)
Gene: MAP3K7
UniProt: O43318 (M3K7_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.89
Assay: Binding affinity to TAK1
Drug: midostaurin
Target: Serine/threonine-protein kinase ULK3 (Kinase)
Gene: ULK3
UniProt: Q6PHR2 (ULK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.89
Assay: Binding affinity to ULK3
Drug: midostaurin
Target: Mitogen-activated protein kinase kinase kinase 19 (Kinase)
Gene: MAP3K19
UniProt: Q56UN5 (M3K19_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.82
Assay: Binding affinity to YSK4
Drug: midostaurin
Target: Tankyrase-2 (Enzyme)
Gene: TNKS2
UniProt: Q9H2K2 (TNKS2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.92
Assay: Binding affinity to TNK2
Drug: midostaurin
Target: Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta (Kinase)
Gene: PIK3C2B
UniProt: O00750 (P3C2B_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.85
Assay: Binding affinity to PIK3C2B
Drug: midostaurin
Target: Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma (Kinase)
Gene: PIK3C2G
UniProt: O75747 (P3C2G_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.24
Assay: Binding affinity to PIK3C2G
Drug: midostaurin
Target: Serine/threonine-protein kinase SIK3 (Kinase)
Gene: SIK3
UniProt: Q9Y2K2 (SIK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.01
Assay: Binding affinity to QSK
Drug: midostaurin
Target: Serine/threonine-protein kinase 32A (Kinase)
Gene: STK32A
UniProt: Q8WU08 (ST32A_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.62
Assay: Binding constant for YANK1 kinase domain
Drug: midostaurin
Target: Serine/threonine-protein kinase PRP4 homolog (Kinase)
Gene: PRPF4B
UniProt: Q13523 (PRP4B_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.26
Assay: Binding constant for PRP4 kinase domain
Drug: midostaurin
Target: Serine/threonine-protein kinase Sgk3 (Kinase)
Gene: SGK3
UniProt: Q96BR1 (SGK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.85
Assay: Binding constant for SGK3 kinase domain
Drug: midostaurin
Target: Myosin light chain kinase 3 (Kinase)
Gene: MYLK3
UniProt: Q32MK0 (MYLK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.64
Assay: Binding constant for MLCK kinase domain
Drug: midostaurin
Target: Leucine-rich repeat serine/threonine-protein kinase 2 (Kinase)
Gene: LRRK2
UniProt: Q5S007 (LRRK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.75
Assay: Binding constant for LRRK2(G2019S) kinase domain
Drug: midostaurin
Target: Dual serine/threonine and tyrosine protein kinase (Kinase)
Gene: DSTYK
UniProt: Q6XUX3 (DUSTY_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.33
Assay: Binding constant for RIPK5 kinase domain