AIM-Harvard/TrialPanorama-filtered huggingface dataset:
Drug: chlorpromazine
Target: Acetylcholine receptor subunit alpha (Ion channel)
Gene: CHRNA1
UniProt: P02710 (ACHA_TORCA)
Organism: Torpedo californica
Activity: IC50 = 5.89
Assay: Displacement of [3H]PCP from nAChR in Torpedo nobiliana electric organs membranes in presence of 100 uM carbachol by scintillation counting method
Drug: chlorpromazine
Target: Glutamate [NMDA] receptor (Ion channel)
Gene: GRIN2D|GRIN3B|GRIN1|GRIN2A|GRIN2B|GRIN2C|GRIN3A
UniProt: O15399|O60391|Q05586|Q12879|Q13224|Q14957|Q8TCU5 (NMDE4_HUMAN|NMD3B_HUMAN|NMDZ1_HUMAN|NMDE1_HUMAN|NMDE2_HUMAN|NMDE3_HUMAN|NMD3A_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.22
Assay: Inhibition of [3H]1 binding to dextromethorpin binding site of guinea pig microsomal pellet P3 N-methyl-D-aspartate glutamate receptor
Drug: chlorpromazine
Target: Glutamate NMDA receptor (Ion channel)
Gene: Grin1|Grin2a|Grin2b|Grin2c|Grin2d|Grin3b|Grin3a
UniProt: P35439|Q00959|Q00960|Q00961|Q62645|Q8VHN2|Q9R1M7 (NMDZ1_RAT|NMDE1_RAT|NMDE2_RAT|NMDE3_RAT|NMDE4_RAT|NMD3B_RAT|NMD3A_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 5.89
Assay: Binding affinity against dextromethorpin binding site of N-methyl-D-aspartate glutamate receptor from rat brain using [3H]1
Drug: chlorpromazine
Target: Muscarinic acetylcholine receptor (GPCR)
Gene: Chrm1|Chrm3|Chrm4|Chrm5|Chrm2
UniProt: P08482|P08483|P08485|P08911|P10980 (ACM1_RAT|ACM3_RAT|ACM4_RAT|ACM5_RAT|ACM2_RAT)
Organism: Rattus norvegicus
Activity: Ki = 7.22
Assay: In vitro binding affinity against Muscarinic acetylcholine receptors in rat brain.
Drug: chlorpromazine
Target: Dopamine receptor (GPCR)
Gene: DRD2|DRD1
UniProt: P20288|Q95136 (DRD2_BOVIN|DRD1_BOVIN)
Organism: Bos taurus
Activity: IC50 = 7.6
Assay: compound was tested for its ability to displace [3H]- spiroperidol from dopamine receptor.
Drug: chlorpromazine
Target: Dopamine receptor (GPCR)
Gene: Drd1|Drd3|Drd5|Drd4|Drd2
UniProt: P18901|P19020|P25115|P30729|P61169 (DRD1_RAT|DRD3_RAT|DRD5_RAT|DRD4_RAT|DRD2_RAT)
Organism: Rattus norvegicus
Activity: Ki = 7.85
Assay: In vitro ability to displace [3H]spiroperidol from rat dopamine receptor
Drug: chlorpromazine
Target: Sodium channel alpha subunits; brain (Types I, II, III) (Ion channel)
Gene: SCN1A|SCN2A|SCN3A
UniProt: P35498|Q99250|Q9NY46 (SCN1A_HUMAN|SCN2A_HUMAN|SCN3A_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.37
Assay: Inhibition of binding of Batrachotoxinin [3H]BTX-B to high affinity sites on voltage dependent sodium channels in a vesicular preparation from guinea pig cerebral cortex
Drug: chlorpromazine
Target: Serotonin 2 (5-HT2) receptor (GPCR)
Gene: Htr2c|Htr2a|Htr2b
UniProt: P08909|P14842|P30994 (5HT2C_RAT|5HT2A_RAT|5HT2B_RAT)
Organism: Rattus norvegicus
Activity: Ki = 9.15
Assay: Binding affinity determined in radioreceptor binding assay by using [3H]ketanserin radioligand against 5-hydroxytryptamine 2 receptor
Drug: chlorpromazine
Target: Adenylate cyclase (Enzyme)
Gene: Adcy1|Adcy3|Adcy2|Adcy4|Adcy8|Adcy6|Adcy5
UniProt: D4A3N4|P21932|P26769|P26770|P40146|Q03343|Q04400|Q8CFM9 (D4A3N4_RAT|ADCY3_RAT|ADCY2_RAT|ADCY4_RAT|ADCY8_RAT|ADCY6_RAT|ADCY5_RAT|Q8CFM9_RAT)
Organism: Rattus norvegicus
Activity: Ki = 6.93
Assay: Inhibitory activity against Dopamine sensitive adenylate cyclase in rats
Drug: chlorpromazine
Target: FAD-linked sulfhydryl oxidase ALR (Enzyme)
Gene: GFER
UniProt: P55789 (ALR_HUMAN)
Organism: Homo sapiens
Activity: AC50 = 5.99
Assay: PUBCHEM_BIOASSAY: HTS-Luminescent assay for inhibitors of ALR by detection of hydrogen peroxide production Measured in Biochemical System Using Plate Reader - 2036-02_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488787]
Drug: chlorpromazine
Target: Calmodulin (Cytosolic other)
Gene: CALM
UniProt: P62157 (CALM_BOVIN)
Organism: Bos taurus
Activity: IC50 = 5.6
Assay: Displacement of [3H]W-7 from bovine brain CaM
Drug: chlorpromazine
Target: Major prion protein (Unclassified)
Gene: Prnp
UniProt: P04925 (PRIO_MOUSE)
Organism: Mus musculus
Activity: EC50 = 5.7
Assay: Activity at mouse prion protein expressed in Escherichia coli
Drug: chlorpromazine
Target: Sphingomyelin phosphodiesterase (Enzyme)
Gene: SMPD1
UniProt: P17405 (ASM_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.96
Assay: Inhibition of mmLDL-stimulated acid sphingomyelinase in human PBMC lysates using 3H-sphingomyelin as substrate preincubated for 30 mins followed by mmLDL stimulation measured after 2 hrs by HPLC method
Drug: chlorpropamide
Target: Solute carrier family 22 member 6 (Transporter)
Gene: Slc22a6
UniProt: O35956 (S22A6_RAT)
Organism: Rattus norvegicus
Activity: Ki = 4.4
Assay: Inhibition of rat Oat1 expressed in Xenopus oocytes
Drug: chlorpropamide
Target: Sulfonylurea receptor 1, Kir6.2 (Ion channel)
Gene: ABCC8|KCNJ11
UniProt: Q09428|Q14654 (ABCC8_HUMAN|KCJ11_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.046
Action type: BLOCKER
Assay: [86]Rb+ efflux in RINm5F insulinoma cells
Drug: chlorprothixene
Target: D(1A) dopamine receptor (GPCR)
Gene: DRD1
UniProt: P21728 (DRD1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.74
Assay: Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells
Drug: chlorprothixene
Target: D(2) dopamine receptor (GPCR)
Gene: DRD2
UniProt: P14416 (DRD2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.53
Action type: ANTAGONIST
Assay: Displacement of [3H]spiperone from human dopamine D2 receptor expressed in CHO cells
Drug: chlorprothixene
Target: 5-hydroxytryptamine receptor 2A (GPCR)
Gene: HTR2A
UniProt: P28223 (5HT2A_HUMAN)
Organism: Homo sapiens
Activity: Ki  9.367
Drug: chlorprothixene
Target: 5-hydroxytryptamine receptor 6 (GPCR)
Gene: HTR6
UniProt: P50406 (5HT6R_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.52
Assay: Binding affinity towards human 5-hydroxytryptamine 6 receptor
Drug: chlorprothixene
Target: D(3) dopamine receptor (GPCR)
Gene: DRD3
UniProt: P35462 (DRD3_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.34
Action type: ANTAGONIST
Assay: Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cells
Drug: chlorprothixene
Target: D(1B) dopamine receptor (GPCR)
Gene: DRD5
UniProt: P21918 (DRD5_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.05
Assay: Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
Drug: chlorprothixene
Target: Histamine H1 receptor (GPCR)
Gene: HRH1
UniProt: P35367 (HRH1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.43
Assay: Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cells
Drug: chlorprothixene
Target: Muscarinic acetylcholine receptor M1 (GPCR)
Gene: CHRM1
UniProt: P11229 (ACM1_HUMAN)
Organism: Homo sapiens
Activity: Ki  7.959
Drug: chlorprothixene
Target: Muscarinic acetylcholine receptor M2 (GPCR)
Gene: CHRM2
UniProt: P08172 (ACM2_HUMAN)
Organism: Homo sapiens
Activity: Ki  7.553
Drug: chlorprothixene
Target: Muscarinic acetylcholine receptor M3 (GPCR)
Gene: CHRM3
UniProt: P20309 (ACM3_HUMAN)
Organism: Homo sapiens
Activity: Ki  7.658
Drug: chlorprothixene
Target: Muscarinic acetylcholine receptor M4 (GPCR)
Gene: CHRM4
UniProt: P08173 (ACM4_HUMAN)
Organism: Homo sapiens
Activity: Ki  7.745
Drug: chlorprothixene
Target: Muscarinic acetylcholine receptor M5 (GPCR)
Gene: CHRM5
UniProt: P08912 (ACM5_HUMAN)
Organism: Homo sapiens
Activity: Ki  7.602
Drug: chlorprothixene
Target: D(4) dopamine receptor (GPCR)
Gene: DRD4
UniProt: P21917 (DRD4_HUMAN)
Organism: Homo sapiens
Activity: Ki  9.194
Drug: chlorprothixene
Target: Solute carrier family 22 member 1 (Transporter)
Gene: SLC22A1
UniProt: O15245 (S22A1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.11
Assay: Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells by confocal microscopy
Drug: chlorprothixene
Target: 5-hydroxytryptamine receptor 7 (GPCR)
Gene: Htr7
UniProt: P32305 (5HT7R_RAT)
Organism: Rattus norvegicus
Activity: Ki = 8.25
Assay: Binding affinity towards rat 5-hydroxytryptamine 7 receptor
Drug: chlorprothixene
Target: Histamine H1 receptor (GPCR)
Gene: Hrh1
UniProt: P31390 (HRH1_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 8.97
Assay: Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation counting
Drug: chlorprothixene
Target: Pleiotropic ABC efflux transporter of multiple drugs (Transporter)
Gene: PDR5
UniProt: P33302 (PDR5_YEAST)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Activity: IC50 = 5.29
Assay: Inhibition of Pdr5p-mediated rhodamine 6G transport in Saccharomyces cerevisiae MKPDR5h plasma membrane by spectrofluorometric assay
Drug: chlortetracycline
Target: cAMP-specific 3',5'-cyclic phosphodiesterase 4A (Enzyme)
Gene: PDE4A
UniProt: P27815 (PDE4A_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4
Assay: Inhibition of PAD4 (unknown origin)
Drug: chlortetracycline
Target: Major prion protein (Surface antigen)
Gene: PRNP
UniProt: P04156 (PRIO_HUMAN)
Organism: Homo sapiens
Drug: chlortetracycline
Target: Protein-arginine deiminase type-4 (Enzyme)
Gene: PADI4
UniProt: Q9UM07 (PADI4_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4
Assay: Inhibition of PAD4 by ABPP-based assay
Drug: chlortalidone
Target: Carbonic anhydrase 2 (Enzyme)
Gene: CA2
UniProt: P00918 (CAH2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.56
Drug: chlortalidone
Target: Solute carrier family 12 member 3 (Transporter)
Gene: SLC12A3
UniProt: P55017 (S12A3_HUMAN)
Organism: Homo sapiens
Action type: INHIBITOR
Assay: Mechanism of Action; CHEMBL1876; SINGLE PROTEIN
Drug: chlortalidone
Target: Carbonic anhydrase 1 (Enzyme)
Gene: CA1
UniProt: P00915 (CAH1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.46
Assay: Inhibition of human recombinant full length CA1 by stopped-flow CO2 hydration method
Drug: chlortalidone
Target: Carbonic anhydrase 4 (Enzyme)
Gene: CA4
UniProt: P22748 (CAH4_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.71
Assay: Inhibition of human recombinant full length CA4 by stopped-flow CO2 hydration method
Drug: chlortalidone
Target: Carbonic anhydrase 9 (Enzyme)
Gene: CA9
UniProt: Q16790 (CAH9_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.64
Assay: Inhibition of human recombinant CA9 catalytic domain by stopped-flow CO2 hydration method
Drug: chlortalidone
Target: Carbonic anhydrase 12 (Enzyme)
Gene: CA12
UniProt: O43570 (CAH12_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.35
Assay: Inhibition of human recombinant CA12 catalytic domain by stopped-flow CO2 hydration method
Drug: chlortalidone
Target: Carbonic anhydrase 5A, mitochondrial (Enzyme)
Gene: CA5A
UniProt: P35218 (CAH5A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.04
Assay: Inhibition of human recombinant full length CA5A by stopped-flow CO2 hydration method
Drug: chlortalidone
Target: Carbonic anhydrase 5B, mitochondrial (Enzyme)
Gene: CA5B
UniProt: Q9Y2D0 (CAH5B_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.05
Assay: Inhibition of human recombinant full length CA5B by stopped-flow CO2 hydration method
Drug: chlortalidone
Target: Carbonic anhydrase 7 (Enzyme)
Gene: CA7
UniProt: P43166 (CAH7_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.55
Assay: Inhibition of human recombinant full length CA7 by stopped-flow CO2 hydration method
Drug: chlortalidone
Target: Carbonic anhydrase 3 (Enzyme)
Gene: CA3
UniProt: P07451 (CAH3_HUMAN)
Organism: Homo sapiens
Activity: Ki = 4.96
Assay: Inhibition of human recombinant full length CA3 by stopped-flow CO2 hydration method
Drug: chlortalidone
Target: Carbonic anhydrase 6 (Enzyme)
Gene: CA6
UniProt: P23280 (CAH6_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.87
Assay: Inhibition of human recombinant full length CA6 by stopped-flow CO2 hydration method
Drug: chlortalidone
Target: Carbonic anhydrase 14 (Enzyme)
Gene: CA14
UniProt: Q9ULX7 (CAH14_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.38
Assay: Inhibition of human recombinant full length CA14 by stopped-flow CO2 hydration method
Drug: chlortalidone
Target: Carbonic anhydrase 13 (Enzyme)
Gene: Ca13
UniProt: Q9D6N1 (CAH13_MOUSE)
Organism: Mus musculus
Activity: Ki = 7.82
Assay: Inhibition of mouse recombinant full length CA13 by stopped-flow CO2 hydration method
Drug: chlorzoxazone
Target: Intermediate conductance calcium-activated potassium channel protein 4 (Ion channel)
Gene: KCNN4
UniProt: O15554 (KCNN4_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 4
Action type: ACTIVATOR
Drug: chlorzoxazone
Target: Nitric oxide synthase, inducible (Enzyme)
Gene: NOS2
UniProt: P35228 (NOS2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.85
Assay: Inhibitory activity against Inducible nitric oxide synthase
Drug: chlorzoxazone
Target: Nitric oxide synthase, brain (Enzyme)
Gene: NOS1
UniProt: P29475 (NOS1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.3
Assay: Inhibitory activity against Neuronal nitric oxide synthase
Drug: chlorzoxazone
Target: Nitric oxide synthase, endothelial (Enzyme)
Gene: NOS3
UniProt: P29474 (NOS3_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.06
Assay: Inhibitory activity against Endothelial nitric oxide synthase
Drug: chlorzoxazone
Target: Nitric oxide synthase, brain (Enzyme)
Gene: Nos1
UniProt: P29476 (NOS1_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 5.554
Assay: DRUGMATRIX: Nitric Oxide Synthase, Neuronal (nNOS) radioligand binding (ligand: [3H]L-Arginine)
Drug: chlorzoxazone
Target: Small conductance calcium-activated potassium channel protein 2 (Ion channel)
Gene: Kcnn2
UniProt: P70604 (KCNN2_RAT)
Organism: Rattus norvegicus
Activity: EC50 = 4.1
Action type: ACTIVATOR
Drug: chlorzoxazone
Target: Calcium-activated potassium channel subunit alpha-1 (Ion channel)
Gene: KCNMA1
UniProt: Q12791 (KCMA1_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 4.523
Action type: OPENER
Assay: Chlorzoxazone-stimulated activity of BK(Ca) channels in neuroblastoma IMR-32 cells
Drug: cianidanol
Target: Prostaglandin G/H synthase 2 (Enzyme)
Gene: PTGS2
UniProt: P35354 (PGH2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.03
Assay: Inhibition of COX2
Drug: cianidanol
Target: Prostaglandin G/H synthase 1 (Enzyme)
Gene: PTGS1
UniProt: P23219 (PGH1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.44
Assay: Inhibition of COX1
Drug: cianidanol
Target: Carbonic anhydrase 2 (Enzyme)
Gene: CA2
UniProt: P00918 (CAH2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.74
Assay: Inhibition of human carbonic anhydrase 2 after 15 mins by stopped flow CO2 hydration method
Drug: cianidanol
Target: Carbonic anhydrase 1 (Enzyme)
Gene: CA1
UniProt: P00915 (CAH1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.62
Assay: Inhibition of human carbonic anhydrase 1 after 15 mins by stopped flow CO2 hydration method
Drug: cianidanol
Target: Carbonic anhydrase 4 (Enzyme)
Gene: CA4
UniProt: P22748 (CAH4_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.31
Assay: Inhibition of human carbonic anhydrase 4 after 15 mins by stopped flow CO2 hydration method
Drug: cianidanol
Target: Carbonic anhydrase 9 (Enzyme)
Gene: CA9
UniProt: Q16790 (CAH9_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.3
Assay: Inhibition of human carbonic anhydrase 9 after 15 mins by stopped flow CO2 hydration method
Drug: cianidanol
Target: Carbonic anhydrase 12 (Enzyme)
Gene: CA12
UniProt: O43570 (CAH12_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.33
Assay: Inhibition of human carbonic anhydrase 12 after 15 mins by stopped flow CO2 hydration method
Drug: cianidanol
Target: Prothrombin (Enzyme)
Gene: F2
UniProt: P00734 (THRB_HUMAN)
Organism: Homo sapiens
Activity: Kd = 4.31
Assay: Inhibition of human thrombin assessed as equilibrium dissociation constant at 50 to 1000 uM by BIAcore analysis
Drug: cianidanol
Target: Mast/stem cell growth factor receptor Kit (Kinase)
Gene: KIT
UniProt: P10721 (KIT_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.8
Assay: Inhibition of N-terminal GST-His-tagged c-KIT (544 to 976 amino acids) D816V mutant (unknown origin) expressed in Sf9 insect cells using poly[Glu:Tyr] (4:1) as substrate preincubated for 20 mins followed by [33P-gamma]ATP addition and subsequent inhibition for 2 hrs by radiometric assay
Drug: cianidanol
Target: Carbonic anhydrase 5A, mitochondrial (Enzyme)
Gene: CA5A
UniProt: P35218 (CAH5A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.38
Assay: Inhibition of human carbonic anhydrase 5a after 15 mins by stopped flow CO2 hydration method
Drug: cianidanol
Target: Carbonic anhydrase 5B, mitochondrial (Enzyme)
Gene: CA5B
UniProt: Q9Y2D0 (CAH5B_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.4
Assay: Inhibition of human carbonic anhydrase 5b after 15 mins by stopped flow CO2 hydration method
Drug: cianidanol
Target: Carbonic anhydrase 7 (Enzyme)
Gene: CA7
UniProt: P43166 (CAH7_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.35
Assay: Inhibition of human carbonic anhydrase 7 after 15 mins by stopped flow CO2 hydration method
Drug: cianidanol
Target: Carbonic anhydrase 3 (Enzyme)
Gene: CA3
UniProt: P07451 (CAH3_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.45
Assay: Inhibition of human carbonic anhydrase 3 after 15 mins by stopped flow CO2 hydration method
Drug: cianidanol
Target: Carbonic anhydrase 6 (Enzyme)
Gene: CA6
UniProt: P23280 (CAH6_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.31
Assay: Inhibition of human carbonic anhydrase 6 after 15 mins by stopped flow CO2 hydration method
Drug: cianidanol
Target: Carbonic anhydrase 14 (Enzyme)
Gene: CA14
UniProt: Q9ULX7 (CAH14_HUMAN)
Organism: Homo sapiens
Activity: Ki = 4.94
Assay: Inhibition of human carbonic anhydrase 14 after 15 mins by stopped flow CO2 hydration method
Drug: cianidanol
Target: Beta-secretase 1 (Enzyme)
Gene: BACE1
UniProt: P56817 (BACE1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.52
Assay: Inhibition of human Beta-secretase 1
Drug: cianidanol
Target: Prostaglandin G/H synthase 1 (Enzyme)
Gene: PTGS1
UniProt: P05979 (PGH1_SHEEP)
Organism: Ovis aries
Activity: Kd = 4.39
Assay: Binding affinity to COX1 in sheep seminal vesicle
Drug: cianidanol
Target: Polyphenol oxidase 2 (Enzyme)
Gene: PPO2
UniProt: O42713 (PPO2_AGABI)
Organism: Agaricus bisporus
Activity: Ki = 5.07
Assay: Competitive type inhibition of monophenolase activity of mushroom tyrosinase assessed as reduction in dopachrome formation using L-Tyrosine substrate by UV-Vis spectrophotometry based Dixon plot analysis
Drug: cianidanol
Target: Carbonic anhydrase 13 (Enzyme)
Gene: CA13
UniProt: Q8N1Q1 (CAH13_HUMAN)
Organism: Homo sapiens
Activity: Ki = 4.98
Assay: Inhibition of human carbonic anhydrase 13 after 15 mins by stopped flow CO2 hydration method
Drug: cianidanol
Target: Carbonic anhydrase 15 (Enzyme)
Gene: Ca15
UniProt: Q99N23 (CAH15_MOUSE)
Organism: Mus musculus
Activity: Ki = 5.11
Drug: cianidanol
Target: Prostaglandin G/H synthase 1 (Enzyme)
Gene: PTGS1
UniProt: O62664 (PGH1_BOVIN)
Organism: Bos taurus
Activity: IC50 = 4.1
Assay: Inhibition of bovine seminal vesicle microsomal COX1-mediated prostaglandin production
Drug: cianidanol
Target: Arginase (Enzyme)
UniProt: O96394 (O96394_LEIAM)
Organism: Leishmania amazonensis
Activity: Ki = 6.22
Assay: Noncompetitive inhibition of Leishmania amazonensis recombinant arginase expressed in Escherichia coli Rosetta (DE3) pLysS using L-arginine as substrate by Dixon reciprocal plot analysis
Drug: cianidanol
Target: Amyloid beta A4 protein (Unclassified)
Gene: APP
UniProt: P05067 (A4_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.48
Assay: Inhibition of wild type Amyloid beta (1 to 42) (unknown origin) aggregation by Thioflavin-T fluorescence assay
Drug: cianidanol
Target: Dihydroorotate dehydrogenase (Enzyme)
Gene: DHODH
UniProt: Q4QEW7 (Q4QEW7_LEIMA)
Organism: Leishmania major
Activity: IC50 = 4.01
Assay: Inhibition of recombinant oligo-histidine-tagged Leishmania major DHODH expressed in Escherichia coli BL21(DE3) cells using DHO as substrate measured after 60 secs
Drug: cibenzoline
Target: Potassium voltage-gated channel subfamily H member 2 (Ion channel)
Gene: KCNH2
UniProt: Q12809 (KCNH2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.06
Assay: Inhibitory concentration against IKr potassium channel
Drug: cibenzoline
Target: ATP-sensitive inward rectifier potassium channel 11 (Ion channel)
Gene: KCNJ11
UniProt: Q14654 (KCJ11_HUMAN)
Organism: Homo sapiens
Drug: cibenzoline
Target: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (Ion channel)
Gene: HCN4
UniProt: Q9Y3Q4 (HCN4_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.33
Drug: cicaprost
Target: Prostaglandin E2 receptor EP1 subtype (GPCR)
Gene: PTGER1
UniProt: P34995 (PE2R1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.9
Drug: cicaprost
Target: Prostaglandin E2 receptor EP3 subtype (GPCR)
Gene: PTGER3
UniProt: P43115 (PE2R3_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.6
Drug: cicaprost
Target: Prostacyclin receptor (GPCR)
Gene: PTGIR
UniProt: P43119 (PI2R_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.8
Drug: cicaprost
Target: Prostaglandin E2 receptor EP4 subtype (GPCR)
Gene: PTGER4
UniProt: P35408 (PE2R4_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.4
Drug: cicaprost
Target: Prostaglandin D2 receptor (GPCR)
Gene: PTGDR
UniProt: Q13258 (PD2R_HUMAN)
Organism: Homo sapiens
Activity: Ki  5.873
Drug: cicaprost
Target: Prostaglandin F2-alpha receptor (GPCR)
Gene: PTGFR
UniProt: P43088 (PF2R_HUMAN)
Organism: Homo sapiens
Activity: Ki  5.873
Drug: cicaprost
Target: Prostaglandin E2 receptor EP2 subtype (GPCR)
Gene: Ptger2
UniProt: Q62053 (PE2R2_MOUSE)
Organism: Mus musculus
Activity: Ki = 5.9
Action type: AGONIST
Drug: cicaprost
Target: Prostaglandin E2 receptor EP3 subtype (GPCR)
Gene: Ptger3
UniProt: P30557 (PE2R3_MOUSE)
Organism: Mus musculus
Activity: Ki = 6.77
Action type: AGONIST
Drug: cicaprost
Target: Prostacyclin receptor (GPCR)
Gene: Ptgir
UniProt: P43252 (PI2R_MOUSE)
Organism: Mus musculus
Activity: Ki = 8
Action type: AGONIST
Drug: cyclacillin
Target: Penicillin-binding protein 1A (Enzyme)
Gene: pbpA
UniProt: Q8XJ01 (PBPA_CLOPE)
Organism: Clostridium perfringens (strain 13 / Type A)
Drug: cyclacillin
Target: Bacterial penicillin-binding protein (Enzyme)
Gene: mrcA|mrcB|dacC|mrdA|ftsI|dacA|dacB
UniProt: P02918|P02919|P08506|P0AD65|P0AD68|P0AEB2|P24228 (PBPA_ECOLI|PBPB_ECOLI|DACC_ECOLI|PBP2_ECOLI|FTSI_ECOLI|DACA_ECOLI|DACB_ECOLI)
Organism: Escherichia coli (strain K12)
Action type: INHIBITOR
Assay: Mechanism of Action; CHEMBL2354204; PROTEIN FAMILY
Drug: ciclesonide
Target: Glucocorticoid receptor (Nuclear hormone receptor)
Gene: NR3C1
UniProt: P04150 (GCR_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.43
Action type: AGONIST
Drug: ciclopirox
Target: Poly [ADP-ribose] polymerase 1 (Enzyme)
Gene: PARP1
UniProt: P09874 (PARP1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.8
Action type: INHIBITOR
Drug: ciclopirox
Target: Poly [ADP-ribose] polymerase 1 (Unclassified)
Gene: PARP1
UniProt: P09874 (PARP1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.8
Action type: INHIBITOR
Drug: ciclopirox
Target: Deoxyhypusine hydroxylase (Enzyme)
Gene: DOHH
UniProt: Q9BU89 (DOHH_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.3
Assay: Inhibition of DOHH (unknown origin)
Drug: cicloprolol
Target: Beta-1 adrenergic receptor (GPCR)
Gene: ADRB1
UniProt: P08588 (ADRB1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8
Drug: cicloprolol
Target: Beta-2 adrenergic receptor (GPCR)
Gene: ADRB2
UniProt: P07550 (ADRB2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.2
Drug: cidofovir
Target: DNA polymerase catalytic subunit (Enzyme)
UniProt: P04293 (DPOL_HHV11)
Organism: Human herpesvirus 1 (strain 17)
Action type: INHIBITOR
Drug: cilastatin
Target: Dipeptidase 1 (Enzyme)
Gene: DPEP1
UniProt: P16444 (DPEP1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.959
Action type: INHIBITOR
Drug: cilastatin
Target: Dipeptidase 1 (Enzyme)
Gene: DPEP1
UniProt: P22412 (DPEP1_PIG)
Organism: Sus scrofa
Activity: Ki = 6.96
Assay: Inhibitory activity against beta-lactamase renal dipeptidase
Drug: cilazapril
Target: Angiotensin-converting enzyme (Enzyme)
Gene: ACE
UniProt: P12821 (ACE_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 8.7
Action type: INHIBITOR
Drug: cilnidipine
Target: Voltage-dependent N-type calcium channel subunit alpha-1B (Ion channel)
Gene: Cacna1b
UniProt: Q02294 (CAC1B_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 6.7
Action type: BLOCKER
Drug: cilnidipine
Target: Voltage-gated L-type calcium channel (Ion channel)
Gene: CACNA1D|CACNA1C
UniProt: Q01668|Q13936 (CAC1D_HUMAN|CAC1C_HUMAN)
Organism: Homo sapiens
Action type: BLOCKER
Assay: Mechanism of Action