AIM-Harvard/TrialPanorama-filtered huggingface dataset:
Drug: vilazodone
Target: Adrenergic receptor alpha-2 (GPCR)
Gene: ADRA2A|ADRA2B|ADRA2C
UniProt: P08913|P18089|P18825 (ADA2A_HUMAN|ADA2B_HUMAN|ADA2C_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.22
Assay: Inhibition of alpha-2-adrenergic receptor
Drug: vilazodone
Target: Adrenergic receptor alpha-1 (GPCR)
Gene: ADRA1D|ADRA1A|ADRA1B
UniProt: P25100|P35348|P35368 (ADA1D_HUMAN|ADA1A_HUMAN|ADA1B_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.7
Assay: Inhibition of alpha-1-adrenergic receptor
Drug: axitinib
Target: Tyrosine-protein kinase JAK3 (Kinase)
Gene: JAK3
UniProt: P52333 (JAK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.51
Assay: Binding constant for JAK3(JH1domain-catalytic) kinase domain
Drug: axitinib
Target: Platelet-derived growth factor receptor beta (Kinase)
Gene: PDGFRB
UniProt: P09619 (PGFRB_HUMAN)
Organism: Homo sapiens
Activity: Kd = 9.24
Assay: Binding constant for PDGFRB kinase domain
Drug: axitinib
Target: Tyrosine-protein kinase ABL1 (Kinase)
Gene: ABL1
UniProt: P00519 (ABL1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.82
Assay: Binding constant for ABL1(T315I)-phosphorylated kinase domain
Drug: axitinib
Target: Mast/stem cell growth factor receptor Kit (Kinase)
Gene: KIT
UniProt: P10721 (KIT_HUMAN)
Organism: Homo sapiens
Activity: Kd = 9.31
Assay: Binding constant for KIT(V559D) kinase domain
Drug: axitinib
Target: Epidermal growth factor receptor (Kinase)
Gene: EGFR
UniProt: P00533 (EGFR_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.64
Assay: Binding constant for EGFR(G719C) kinase domain
Drug: axitinib
Target: Tyrosine-protein kinase Lck (Kinase)
Gene: LCK
UniProt: P06239 (LCK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.57
Assay: Binding constant for LCK kinase domain
Drug: axitinib
Target: Tyrosine-protein kinase Yes (Kinase)
Gene: YES1
UniProt: P07947 (YES_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.57
Assay: Binding constant for YES kinase domain
Drug: axitinib
Target: Receptor-type tyrosine-protein kinase FLT3 (Kinase)
Gene: FLT3
UniProt: P36888 (FLT3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.51
Assay: Binding constant for FLT3(K663Q) kinase domain
Drug: axitinib
Target: Proto-oncogene tyrosine-protein kinase receptor Ret (Kinase)
Gene: RET
UniProt: P07949 (RET_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7
Assay: Binding constant for RET(M918T) kinase domain
Drug: axitinib
Target: Vascular endothelial growth factor receptor 1 (Kinase)
Gene: FLT1
UniProt: P17948 (VGFR1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.24
Action type: INHIBITOR
Assay: Binding constant for FLT1 kinase domain
Drug: axitinib
Target: Vascular endothelial growth factor receptor 2 (Kinase)
Gene: KDR
UniProt: P35968 (VGFR2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.23
Action type: INHIBITOR
Assay: Binding constant for VEGFR2 kinase domain
Drug: axitinib
Target: Vascular endothelial growth factor receptor 3 (Kinase)
Gene: FLT4
UniProt: P35916 (VGFR3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.77
Action type: INHIBITOR
Assay: Binding constant for FLT4 kinase domain
Drug: axitinib
Target: Macrophage colony-stimulating factor 1 receptor (Kinase)
Gene: CSF1R
UniProt: P07333 (CSF1R_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.68
Assay: Binding constant for CSF1R kinase domain
Drug: axitinib
Target: Platelet-derived growth factor receptor alpha (Kinase)
Gene: PDGFRA
UniProt: P16234 (PGFRA_HUMAN)
Organism: Homo sapiens
Activity: Kd = 9.29
Assay: Binding constant for PDGFRA kinase domain
Drug: axitinib
Target: Mitogen-activated protein kinase 8 (Kinase)
Gene: MAPK8
UniProt: P45983 (MK08_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.41
Assay: Binding constant for JNK1 kinase domain
Drug: axitinib
Target: Fibroblast growth factor receptor 3 (Kinase)
Gene: FGFR3
UniProt: P22607 (FGFR3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.68
Assay: Binding constant for FGFR3 kinase domain
Drug: axitinib
Target: Mitogen-activated protein kinase 10 (Kinase)
Gene: MAPK10
UniProt: P53779 (MK10_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.96
Assay: Binding constant for JNK3 kinase domain
Drug: axitinib
Target: High affinity nerve growth factor receptor (Kinase)
Gene: NTRK1
UniProt: P04629 (NTRK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.74
Assay: Binding constant for TRKA kinase domain
Drug: axitinib
Target: Tyrosine-protein kinase JAK2 (Kinase)
Gene: JAK2
UniProt: O60674 (JAK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.48
Assay: Binding constant for JAK2(JH1domain-catalytic) kinase domain
Drug: axitinib
Target: Myosin light chain kinase 2, skeletal/cardiac muscle (Kinase)
Gene: MYLK2
UniProt: Q9H1R3 (MYLK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.89
Assay: Binding constant for MYLK2 kinase domain
Drug: axitinib
Target: Tyrosine-protein kinase CSK (Kinase)
Gene: CSK
UniProt: P41240 (CSK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.96
Assay: Binding constant for CSK kinase domain
Drug: axitinib
Target: Angiopoietin-1 receptor (Kinase)
Gene: TEK
UniProt: Q02763 (TIE2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.51
Assay: Binding constant for TIE2 kinase domain
Drug: axitinib
Target: AP2-associated protein kinase 1 (Kinase)
Gene: AAK1
UniProt: Q2M2I8 (AAK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.92
Assay: Binding constant for AAK1 kinase domain
Drug: axitinib
Target: Hepatocyte growth factor receptor (Kinase)
Gene: MET
UniProt: P08581 (MET_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.09
Assay: Binding constant for MET kinase domain
Drug: axitinib
Target: Fibroblast growth factor receptor 1 (Kinase)
Gene: FGFR1
UniProt: P11362 (FGFR1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.42
Assay: Binding constant for FGFR1 kinase domain
Drug: axitinib
Target: Serine/threonine-protein kinase 10 (Kinase)
Gene: STK10
UniProt: O94804 (STK10_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.92
Assay: Binding constant for LOK kinase domain
Drug: axitinib
Target: Serine/threonine-protein kinase PLK4 (Kinase)
Gene: PLK4
UniProt: O00444 (PLK4_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.38
Assay: Inhibition of human PLK4
Drug: axitinib
Target: Aurora kinase C (Kinase)
Gene: AURKC
UniProt: Q9UQB9 (AURKC_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.89
Assay: Binding constant for AURKC kinase domain
Drug: axitinib
Target: Serine/threonine-protein kinase 16 (Kinase)
Gene: STK16
UniProt: O75716 (STK16_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.43
Assay: Binding constant for STK16 kinase domain
Drug: axitinib
Target: Dual specificity protein kinase TTK (Kinase)
Gene: TTK
UniProt: P33981 (TTK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.41
Assay: Binding constant for TTK kinase domain
Drug: axitinib
Target: Abelson tyrosine-protein kinase 2 (Kinase)
Gene: ABL2
UniProt: P42684 (ABL2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.15
Assay: Binding constant for ABL2 kinase domain
Drug: axitinib
Target: Fibroblast growth factor receptor 2 (Kinase)
Gene: FGFR2
UniProt: P21802 (FGFR2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.96
Assay: Binding constant for FGFR2 kinase domain
Drug: axitinib
Target: TRAF2 and NCK-interacting protein kinase (Kinase)
Gene: TNIK
UniProt: Q9UKE5 (TNIK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.74
Assay: Binding constant for TNIK kinase domain
Drug: axitinib
Target: Tyrosine-protein kinase Fgr (Kinase)
Gene: FGR
UniProt: P09769 (FGR_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.74
Assay: Binding constant for FGR kinase domain
Drug: axitinib
Target: Aurora kinase A (Kinase)
Gene: AURKA
UniProt: O14965 (AURKA_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.14
Assay: Binding constant for AURKA kinase domain
Drug: axitinib
Target: BMP-2-inducible protein kinase (Kinase)
Gene: BMP2K
UniProt: Q9NSY1 (BMP2K_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6
Assay: Binding constant for BIKE kinase domain
Drug: axitinib
Target: Mitogen-activated protein kinase kinase kinase kinase 5 (Kinase)
Gene: MAP4K5
UniProt: Q9Y4K4 (M4K5_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.26
Assay: Binding constant for MAP4K5 kinase domain
Drug: axitinib
Target: Mitogen-activated protein kinase kinase kinase 4 (Kinase)
Gene: MAP3K4
UniProt: Q9Y6R4 (M3K4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.25
Assay: Binding constant for MAP3K4 kinase domain
Drug: axitinib
Target: Cyclin-G-associated kinase (Kinase)
Gene: GAK
UniProt: O14976 (GAK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.57
Assay: Binding constant for GAK kinase domain
Drug: axitinib
Target: Receptor-interacting serine/threonine-protein kinase 2 (Kinase)
Gene: RIPK2
UniProt: O43353 (RIPK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5
Assay: Binding constant for RIPK2 kinase domain
Drug: axitinib
Target: Cyclin-dependent kinase 16 (Kinase)
Gene: CDK16
UniProt: Q00536 (CDK16_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.28
Assay: Binding constant for PCTK1 kinase domain
Drug: axitinib
Target: Serine/threonine-protein kinase 4 (Kinase)
Gene: STK4
UniProt: Q13043 (STK4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.85
Assay: Binding constant for MST1 kinase domain
Drug: axitinib
Target: Activated CDC42 kinase 1 (Kinase)
Gene: TNK2
UniProt: Q07912 (ACK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.22
Assay: Binding constant for TNK2 kinase domain
Drug: axitinib
Target: STE20-like serine/threonine-protein kinase (Kinase)
Gene: SLK
UniProt: Q9H2G2 (SLK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6
Assay: Binding constant for SLK kinase domain
Drug: axitinib
Target: Calcium/calmodulin-dependent protein kinase kinase 2 (Kinase)
Gene: CAMKK2
UniProt: Q96RR4 (KKCC2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.82
Assay: Binding constant for CAMKK2 kinase domain
Drug: axitinib
Target: Calcium/calmodulin-dependent protein kinase kinase 1 (Kinase)
Gene: CAMKK1
UniProt: Q8N5S9 (KKCC1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.85
Assay: Binding constant for CAMKK1 kinase domain
Drug: axitinib
Target: Epithelial discoidin domain-containing receptor 1 (Kinase)
Gene: DDR1
UniProt: Q08345 (DDR1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.47
Assay: Binding constant for DDR1 kinase domain
Drug: axitinib
Target: Dual specificity mitogen-activated protein kinase kinase 1 (Kinase)
Gene: MAP2K1
UniProt: Q02750 (MP2K1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.57
Assay: Binding constant for MEK1 kinase domain
Drug: axitinib
Target: Dual specificity mitogen-activated protein kinase kinase 2 (Kinase)
Gene: MAP2K2
UniProt: P36507 (MP2K2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.59
Assay: Binding constant for MEK2 kinase domain
Drug: axitinib
Target: Tyrosine-protein kinase ITK/TSK (Kinase)
Gene: ITK
UniProt: Q08881 (ITK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.92
Assay: Binding constant for ITK kinase domain
Drug: axitinib
Target: Tyrosine-protein kinase receptor UFO (Kinase)
Gene: AXL
UniProt: P30530 (UFO_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.38
Assay: Binding constant for AXL kinase domain
Drug: axitinib
Target: Serine/threonine-protein kinase N2 (Kinase)
Gene: PKN2
UniProt: Q16513 (PKN2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.57
Assay: Binding constant for PKN2 kinase domain
Drug: axitinib
Target: Serine/threonine-protein kinase 3 (Kinase)
Gene: STK3
UniProt: Q13188 (STK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.66
Assay: Binding constant for MST2 kinase domain
Drug: axitinib
Target: NUAK family SNF1-like kinase 2 (Kinase)
Gene: NUAK2
UniProt: Q9H093 (NUAK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.89
Assay: Binding constant for SNARK kinase domain
Drug: axitinib
Target: Non-receptor tyrosine-protein kinase TNK1 (Kinase)
Gene: TNK1
UniProt: Q13470 (TNK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.8
Assay: Binding constant for TNK1 kinase domain
Drug: axitinib
Target: Non-receptor tyrosine-protein kinase TYK2 (Kinase)
Gene: TYK2
UniProt: P29597 (TYK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.44
Assay: Binding constant for TYK2(JH1domain-catalytic) kinase domain
Drug: axitinib
Target: Mitogen-activated protein kinase kinase kinase MLT (Kinase)
Gene: ZAK
UniProt: Q9NYL2 (MLTK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.59
Assay: Binding constant for ZAK kinase domain
Drug: axitinib
Target: Serine/threonine-protein kinase RIO1 (Kinase)
Gene: RIOK1
UniProt: Q9BRS2 (RIOK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.92
Assay: Binding constant for RIOK1 kinase domain
Drug: axitinib
Target: Tyrosine-protein kinase receptor Tie-1 (Kinase)
Gene: TIE1
UniProt: P35590 (TIE1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.01
Assay: Binding constant for TIE1 kinase domain
Drug: axitinib
Target: Tyrosine-protein kinase TXK (Kinase)
Gene: TXK
UniProt: P42681 (TXK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.62
Assay: Binding constant for TXK kinase domain
Drug: axitinib
Target: Casein kinase II subunit alpha' (Kinase)
Gene: CSNK2A2
UniProt: P19784 (CSK22_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.55
Assay: Binding constant for CSNK2A2 kinase domain
Drug: axitinib
Target: Serine/threonine-protein kinase RIO3 (Kinase)
Gene: RIOK3
UniProt: O14730 (RIOK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6
Assay: Binding constant for RIOK3 kinase domain
Drug: axitinib
Target: SRSF protein kinase 1 (Kinase)
Gene: SRPK1
UniProt: Q96SB4 (SRPK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.74
Assay: Binding constant for SRPK1 kinase domain
Drug: axitinib
Target: Activin receptor type-2B (Kinase)
Gene: ACVR2B
UniProt: Q13705 (AVR2B_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.28
Assay: Binding constant for ACVR2B kinase domain
Drug: axitinib
Target: Ankyrin repeat and protein kinase domain-containing protein 1 (Kinase)
Gene: ANKK1
UniProt: Q8NFD2 (ANKK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.44
Assay: Binding constant for ANKK1 kinase domain
Drug: axitinib
Target: Discoidin domain-containing receptor 2 (Kinase)
Gene: DDR2
UniProt: Q16832 (DDR2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.28
Assay: Binding constant for DDR2 kinase domain
Drug: axitinib
Target: Mitogen-activated protein kinase kinase kinase kinase 1 (Kinase)
Gene: MAP4K1
UniProt: Q92918 (M4K1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.48
Assay: Binding constant for HPK1 kinase domain
Drug: axitinib
Target: Mitogen-activated protein kinase kinase kinase kinase 3 (Kinase)
Gene: MAP4K3
UniProt: Q8IVH8 (M4K3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.92
Assay: Binding constant for MAP4K3 kinase domain
Drug: axitinib
Target: Aurora kinase B (Kinase)
Gene: AURKB
UniProt: Q96GD4 (AURKB_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.96
Assay: Binding constant for AURKB kinase domain
Drug: axitinib
Target: Tyrosine-protein kinase Blk (Kinase)
Gene: BLK
UniProt: P51451 (BLK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.51
Assay: Binding constant for BLK kinase domain
Drug: axitinib
Target: Mitogen-activated protein kinase kinase kinase kinase 4 (Kinase)
Gene: MAP4K4
UniProt: O95819 (M4K4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.46
Assay: Binding constant for MAP4K4 kinase domain
Drug: axitinib
Target: Tyrosine-protein kinase Mer (Kinase)
Gene: MERTK
UniProt: Q12866 (MERTK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.49
Assay: Binding constant for MERTK kinase domain
Drug: axitinib
Target: Mitogen-activated protein kinase kinase kinase 9 (Kinase)
Gene: MAP3K9
UniProt: P80192 (M3K9_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.52
Assay: Binding constant for MLK1 kinase domain
Drug: axitinib
Target: Serine/threonine-protein kinase MRCK beta (Kinase)
Gene: CDC42BPB
UniProt: Q9Y5S2 (MRCKB_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.32
Assay: Binding constant for MRCKB kinase domain
Drug: axitinib
Target: Myosin-IIIa (Kinase)
Gene: MYO3A
UniProt: Q8NEV4 (MYO3A_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.72
Assay: Binding constant for MYO3A kinase domain
Drug: axitinib
Target: Serine/threonine-protein kinase PAK 4 (Kinase)
Gene: PAK4
UniProt: O96013 (PAK4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.35
Assay: Binding constant for PAK4 kinase domain
Drug: axitinib
Target: Serine/threonine-protein kinase SIK1 (Kinase)
Gene: SIK1
UniProt: P57059 (SIK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.68
Assay: Binding constant for SIK kinase domain
Drug: axitinib
Target: Dual specificity testis-specific protein kinase 1 (Kinase)
Gene: TESK1
UniProt: Q15569 (TESK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.37
Assay: Binding constant for TESK1 kinase domain
Drug: axitinib
Target: Interferon-induced, double-stranded RNA-activated protein kinase (Kinase)
Gene: EIF2AK2
UniProt: P19525 (E2AK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.13
Assay: Binding constant for PRKR kinase domain
Drug: axitinib
Target: Receptor-interacting serine/threonine-protein kinase 1 (Kinase)
Gene: RIPK1
UniProt: Q13546 (RIPK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.6
Assay: Binding constant for RIPK1 kinase domain
Drug: axitinib
Target: Proto-oncogene tyrosine-protein kinase ROS (Kinase)
Gene: ROS1
UniProt: P08922 (ROS1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.49
Assay: Binding constant for ROS1 kinase domain
Drug: axitinib
Target: Mitogen-activated protein kinase kinase kinase kinase 2 (Kinase)
Gene: MAP4K2
UniProt: Q12851 (M4K2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.89
Assay: Binding constant for MAP4K2 kinase domain
Drug: axitinib
Target: Misshapen-like kinase 1 (Kinase)
Gene: MINK1
UniProt: Q8N4C8 (MINK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.25
Assay: Binding constant for MINK kinase domain
Drug: axitinib
Target: Cyclin-dependent kinase-like 2 (Kinase)
Gene: CDKL2
UniProt: Q92772 (CDKL2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.28
Assay: Binding constant for CDKL2 kinase domain
Drug: axitinib
Target: Ephrin type-B receptor 6 (Kinase)
Gene: EPHB6
UniProt: O15197 (EPHB6_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.44
Assay: Binding constant for EPHB6 kinase domain
Drug: axitinib
Target: G protein-coupled receptor kinase 4 (Kinase)
Gene: GRK4
UniProt: P32298 (GRK4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.64
Assay: Binding constant for GRK4 kinase domain
Drug: axitinib
Target: Hormonally up-regulated neu tumor-associated kinase (Kinase)
Gene: HUNK
UniProt: P57058 (HUNK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.82
Assay: Binding constant for HUNK kinase domain
Drug: axitinib
Target: Interleukin-1 receptor-associated kinase 1 (Kinase)
Gene: IRAK1
UniProt: P51617 (IRAK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.51
Assay: Binding constant for IRAK1 kinase domain
Drug: axitinib
Target: Mitogen-activated protein kinase kinase kinase 3 (Kinase)
Gene: MAP3K3
UniProt: Q99759 (M3K3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.55
Assay: Binding constant for MAP3K3 kinase domain
Drug: axitinib
Target: SRSF protein kinase 3 (Kinase)
Gene: SRPK3
UniProt: Q9UPE1 (SRPK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.64
Assay: Binding constant for SRPK3 kinase domain
Drug: axitinib
Target: Serine/threonine-protein kinase ULK2 (Kinase)
Gene: ULK2
UniProt: Q8IYT8 (ULK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5
Assay: Binding constant for ULK2 kinase domain
Drug: axitinib
Target: Serine/threonine-protein kinase ULK3 (Kinase)
Gene: ULK3
UniProt: Q6PHR2 (ULK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.17
Assay: Binding constant for ULK3 kinase domain
Drug: axitinib
Target: Mitogen-activated protein kinase kinase kinase 19 (Kinase)
Gene: MAP3K19
UniProt: Q56UN5 (M3K19_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.57
Assay: Binding constant for YSK4 kinase domain
Drug: axitinib
Target: Receptor-interacting serine/threonine-protein kinase 4 (Kinase)
Gene: RIPK4
UniProt: P57078 (RIPK4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.85
Assay: Binding constant for RIPK4 kinase domain
Drug: axitinib
Target: Bone morphogenetic protein receptor type-1B (Kinase)
Gene: BMPR1B
UniProt: O00238 (BMR1B_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.54
Assay: Binding constant for BMPR1B kinase domain
Drug: axitinib
Target: Mitogen-activated protein kinase kinase kinase 12 (Kinase)
Gene: MAP3K12
UniProt: Q12852 (M3K12_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.77
Assay: Binding constant for DLK kinase domain
Drug: axitinib
Target: Dual specificity mitogen-activated protein kinase kinase 5 (Kinase)
Gene: MAP2K5
UniProt: Q13163 (MP2K5_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.85
Assay: Binding constant for MEK5 kinase domain
Drug: axitinib
Target: Myosin light chain kinase 3 (Kinase)
Gene: MYLK3
UniProt: Q32MK0 (MYLK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.77
Assay: Binding constant for MLCK kinase domain
Drug: axitinib
Target: Leucine-rich repeat serine/threonine-protein kinase 2 (Kinase)
Gene: LRRK2
UniProt: Q5S007 (LRRK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.04
Assay: Binding constant for LRRK2 kinase domain
Drug: ingenol mebutate
Target: Protein kinase C gamma type (Kinase)
Gene: PRKCG
UniProt: P05129 (KPCG_HUMAN)
Organism: Homo sapiens
Activity: Ki = 9.79
Action type: ACTIVATOR
Drug: ingenol mebutate
Target: Protein kinase C beta type (Kinase)
Gene: PRKCB
UniProt: P05771 (KPCB_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 6.836
Assay: Colo-205 cells
Drug: ingenol mebutate
Target: Protein kinase C alpha type (Kinase)
Gene: PRKCA
UniProt: P17252 (KPCA_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 6.197
Assay: Colo-205 cells
Drug: ingenol mebutate
Target: Protein kinase C epsilon type (Kinase)
Gene: PRKCE
UniProt: Q02156 (KPCE_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 8.959
Assay: Colo-205 cells
Drug: ingenol mebutate
Target: Serine/threonine-protein kinase D1 (Kinase)
Gene: PRKD1
UniProt: Q15139 (KPCD1_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 7.523
Assay: Colo-205 cells
Drug: ingenol mebutate
Target: Protein kinase C delta type (Kinase)
Gene: PRKCD
UniProt: Q05655 (KPCD_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 8.328
Action type: ACTIVATOR
Assay: Colo-205 cells
Drug: vismodegib
Target: Sonic hedgehog protein (Enzyme)
Gene: Shh
UniProt: Q62226 (SHH_MOUSE)
Organism: Mus musculus
Activity: IC50 = 8.52
Assay: Inhibition of SHH in mouse Shh Light2 cells by GLI-responsive firefly luciferase reporter gene assay
Drug: vismodegib
Target: Sonic hedgehog protein (Enzyme)
Gene: SHH
UniProt: Q15465 (SHH_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7.82
Assay: Inhibition of human SHH pathway in mouse S12 cells assessed as GLI-mediated transcriptional activity after 48 hrs by luciferase reporter gene assay
Drug: vismodegib
Target: Smoothened homolog (GPCR)
Gene: SMO
UniProt: Q99835 (SMO_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.79
Action type: INHIBITOR
Assay: Displacement of [3H]cyclopamine from wild type Smo expressed in U2OS cells after 2 hrs by scintillation counting
Drug: vismodegib
Target: Smoothened homolog (GPCR)
Gene: Smo
UniProt: P56726 (SMO_MOUSE)
Organism: Mus musculus
Activity: IC50 = 8.3
Assay: Inhibition of Smo in mouse C3H10T1/2 cells using human recombinant SHH assessed as effect on SMO/SHH transient transcriptional activation after 20 hrs by Gli-luciferase reporter assay
Drug: ivacaftor
Target: Cystic fibrosis transmembrane conductance regulator (Ion channel)
Gene: CFTR
UniProt: P13569 (CFTR_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 8.52
Action type: POSITIVE MODULATOR
Assay: Potentiation of human CFTR F508del mutant expressed in mouse NIH-3T3 cells after 30 mins by fluorescent voltage sensing optical assay
Drug: tafluprost
Target: Prostaglandin F2-alpha receptor (GPCR)
Gene: PTGFR
UniProt: P43088 (PF2R_HUMAN)
Organism: Homo sapiens
Action type: AGONIST
Assay: Mechanism of Action; CHEMBL1987; SINGLE PROTEIN
Drug: peginesatide
Target: Erythropoietin receptor (Membrane receptor)
Gene: EPOR
UniProt: P19235 (EPOR_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 10.43
Action type: AGONIST
Drug: avobenzone
Target: Tyrosinase (Enzyme)
Gene: TYR
UniProt: P14679 (TYRO_HUMAN)
Organism: Homo sapiens
Action type: INHIBITOR
Assay: Mechanism of Action; CHEMBL1973; SINGLE PROTEIN
Drug: neomycin
Target: Transient receptor potential cation channel subfamily V member 1 (Ion channel)
Gene: TRPV1
UniProt: Q8NER1 (TRPV1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.4
Assay: Inhibition of TRPV1-mediated membrane currents in human DRG neurons
Drug: neomycin
Target: Lethal factor (Enzyme)
Gene: lef
UniProt: P15917 (LEF_BACAN)
Organism: Bacillus anthracis
Activity: Ki = 6.3
Assay: Inhibition of anthrax lethal factor metalloprotease