AIM-Harvard/TrialPanorama-filtered huggingface dataset:
Drug: fedratinib
Target: Serine/threonine-protein kinase LATS2 (Kinase)
Gene: LATS2
UniProt: Q9NRM7 (LATS2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.1
Assay: Binding constant for LATS2 kinase domain
Drug: fedratinib
Target: Leukocyte tyrosine kinase receptor (Kinase)
Gene: LTK
UniProt: P29376 (LTK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.2
Assay: Binding constant for LTK kinase domain
Drug: fedratinib
Target: Mitogen-activated protein kinase kinase kinase kinase 1 (Kinase)
Gene: MAP4K1
UniProt: Q92918 (M4K1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.89
Assay: Binding constant for HPK1 kinase domain
Drug: fedratinib
Target: Serine/threonine-protein kinase PAK 6 (Kinase)
Gene: PAK6
UniProt: Q9NQU5 (PAK6_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.16
Assay: Binding constant for PAK6 kinase domain
Drug: fedratinib
Target: Serine/threonine-protein kinase PAK 7 (Kinase)
Gene: PAK5
UniProt: Q9P286 (PAK5_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.92
Assay: Binding constant for PAK7 kinase domain
Drug: fedratinib
Target: NUAK family SNF1-like kinase 1 (Kinase)
Gene: NUAK1
UniProt: O60285 (NUAK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.47
Assay: Binding constant for ARK5 kinase domain
Drug: fedratinib
Target: Mitogen-activated protein kinase kinase kinase kinase 3 (Kinase)
Gene: MAP4K3
UniProt: Q8IVH8 (M4K3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.75
Assay: Binding constant for MAP4K3 kinase domain
Drug: fedratinib
Target: Aurora kinase B (Kinase)
Gene: AURKB
UniProt: Q96GD4 (AURKB_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.31
Assay: Binding constant for AURKB kinase domain
Drug: fedratinib
Target: Tyrosine-protein kinase Blk (Kinase)
Gene: BLK
UniProt: P51451 (BLK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.19
Assay: Binding constant for BLK kinase domain
Drug: fedratinib
Target: Bone morphogenetic protein receptor type-2 (Kinase)
Gene: BMPR2
UniProt: Q13873 (BMPR2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.54
Assay: Binding constant for BMPR2 kinase domain
Drug: fedratinib
Target: Serine/threonine-protein kinase MARK1 (Kinase)
Gene: MARK1
UniProt: Q9P0L2 (MARK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.16
Assay: Binding constant for MARK1 kinase domain
Drug: fedratinib
Target: MAP/microtubule affinity-regulating kinase 4 (Kinase)
Gene: MARK4
UniProt: Q96L34 (MARK4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.01
Assay: Binding constant for MARK4 kinase domain
Drug: fedratinib
Target: Dual specificity mitogen-activated protein kinase kinase 4 (Kinase)
Gene: MAP2K4
UniProt: P45985 (MP2K4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5
Assay: Binding constant for MEK4 kinase domain
Drug: fedratinib
Target: Tyrosine-protein kinase Mer (Kinase)
Gene: MERTK
UniProt: Q12866 (MERTK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.09
Assay: Binding constant for MERTK kinase domain
Drug: fedratinib
Target: Mitogen-activated protein kinase kinase kinase 9 (Kinase)
Gene: MAP3K9
UniProt: P80192 (M3K9_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.5
Assay: Binding constant for MLK1 kinase domain
Drug: fedratinib
Target: Mitogen-activated protein kinase kinase kinase 10 (Kinase)
Gene: MAP3K10
UniProt: Q02779 (M3K10_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.16
Assay: Binding constant for MLK2 kinase domain
Drug: fedratinib
Target: Mitogen-activated protein kinase kinase kinase 11 (Kinase)
Gene: MAP3K11
UniProt: Q16584 (M3K11_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.51
Assay: Binding constant for MLK3 kinase domain
Drug: fedratinib
Target: Muscle, skeletal receptor tyrosine-protein kinase (Kinase)
Gene: MUSK
UniProt: O15146 (MUSK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.1
Assay: Binding constant for MUSK kinase domain
Drug: fedratinib
Target: Citron Rho-interacting kinase (Kinase)
Gene: CIT
UniProt: O14578 (CTRO_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.85
Assay: Binding constant for CIT kinase domain
Drug: fedratinib
Target: Death-associated protein kinase 1 (Kinase)
Gene: DAPK1
UniProt: P53355 (DAPK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.8
Assay: Binding constant for DAPK1 kinase domain
Drug: fedratinib
Target: Serine/threonine-protein kinase DCLK1 (Kinase)
Gene: DCLK1
UniProt: O15075 (DCLK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.72
Assay: Binding constant for DCAMKL1 kinase domain
Drug: fedratinib
Target: Serine/threonine-protein kinase DCLK2 (Kinase)
Gene: DCLK2
UniProt: Q8N568 (DCLK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.06
Assay: Binding constant for DCAMKL2 kinase domain
Drug: fedratinib
Target: Serine/threonine-protein kinase Nek5 (Kinase)
Gene: NEK5
UniProt: Q6P3R8 (NEK5_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.24
Assay: Binding constant for NEK5 kinase domain
Drug: fedratinib
Target: Serine/threonine-protein kinase Nek9 (Kinase)
Gene: NEK9
UniProt: Q8TD19 (NEK9_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.82
Assay: Binding constant for NEK9 kinase domain
Drug: fedratinib
Target: Serine/threonine-protein kinase PAK 1 (Kinase)
Gene: PAK1
UniProt: Q13153 (PAK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.51
Assay: Binding constant for PAK1 kinase domain
Drug: fedratinib
Target: Serine/threonine-protein kinase PAK 2 (Kinase)
Gene: PAK2
UniProt: Q13177 (PAK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.22
Assay: Binding constant for PAK2 kinase domain
Drug: fedratinib
Target: Serine/threonine-protein kinase PAK 4 (Kinase)
Gene: PAK4
UniProt: O96013 (PAK4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.42
Assay: Binding constant for PAK4 kinase domain
Drug: fedratinib
Target: AarF domain-containing protein kinase 4 (Kinase)
Gene: COQ8B
UniProt: Q96D53 (COQ8B_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.52
Assay: Binding constant for ADCK4 kinase domain
Drug: fedratinib
Target: Serine/threonine-protein kinase SIK1 (Kinase)
Gene: SIK1
UniProt: P57059 (SIK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.41
Assay: Binding constant for SIK kinase domain
Drug: fedratinib
Target: Tyrosine-protein kinase Srms (Kinase)
Gene: SRMS
UniProt: Q9H3Y6 (SRMS_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.3
Assay: Binding constant for SRMS kinase domain
Drug: fedratinib
Target: Dual specificity testis-specific protein kinase 1 (Kinase)
Gene: TESK1
UniProt: Q15569 (TESK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.5
Assay: Binding constant for TESK1 kinase domain
Drug: fedratinib
Target: Ephrin type-A receptor 1 (Kinase)
Gene: EPHA1
UniProt: P21709 (EPHA1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.14
Assay: Binding constant for EPHA1 kinase domain
Drug: fedratinib
Target: Serine/threonine-protein kinase PLK3 (Kinase)
Gene: PLK3
UniProt: Q9H4B4 (PLK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.8
Assay: Binding constant for PLK3 kinase domain
Drug: fedratinib
Target: Mitogen-activated protein kinase 6 (Kinase)
Gene: MAPK6
UniProt: Q16659 (MK06_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.92
Assay: Binding constant for ERK3 kinase domain
Drug: fedratinib
Target: Mitogen-activated protein kinase 7 (Kinase)
Gene: MAPK7
UniProt: Q13164 (MK07_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.18
Assay: Binding constant for ERK5 kinase domain
Drug: fedratinib
Target: Mitogen-activated protein kinase 15 (Kinase)
Gene: MAPK15
UniProt: Q8TD08 (MK15_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.29
Assay: Binding constant for ERK8 kinase domain
Drug: fedratinib
Target: Serine/threonine-protein kinase D3 (Kinase)
Gene: PRKD3
UniProt: O94806 (KPCD3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.02
Assay: Binding constant for PRKD3 kinase domain
Drug: fedratinib
Target: cGMP-dependent protein kinase 2 (Kinase)
Gene: PRKG2
UniProt: Q13237 (KGP2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.8
Assay: Binding constant for PRKG2 kinase domain
Drug: fedratinib
Target: Interferon-induced, double-stranded RNA-activated protein kinase (Kinase)
Gene: EIF2AK2
UniProt: P19525 (E2AK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.96
Assay: Binding constant for PRKR kinase domain
Drug: fedratinib
Target: Receptor-interacting serine/threonine-protein kinase 1 (Kinase)
Gene: RIPK1
UniProt: Q13546 (RIPK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.28
Assay: Binding constant for RIPK1 kinase domain
Drug: fedratinib
Target: Tyrosine-protein kinase Fes/Fps (Kinase)
Gene: FES
UniProt: P07332 (FES_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.28
Assay: Binding constant for FES kinase domain
Drug: fedratinib
Target: Fibroblast growth factor receptor 4 (Kinase)
Gene: FGFR4
UniProt: P22455 (FGFR4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.7
Assay: Binding constant for FGFR4 kinase domain
Drug: fedratinib
Target: Proto-oncogene tyrosine-protein kinase ROS (Kinase)
Gene: ROS1
UniProt: P08922 (ROS1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.22
Assay: Binding constant for ROS1 kinase domain
Drug: fedratinib
Target: Ribosomal protein S6 kinase alpha-1 (Kinase)
Gene: RPS6KA1
UniProt: Q15418 (KS6A1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.38
Assay: Binding constant for RSK1(Kin.Dom.2-C-terminal) kinase domain
Drug: fedratinib
Target: Ribosomal protein S6 kinase alpha-4 (Kinase)
Gene: RPS6KA4
UniProt: O75676 (KS6A4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.85
Assay: Binding constant for RPS6KA4(Kin.Dom.2-C-terminal) kinase domain
Drug: fedratinib
Target: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Kinase)
Gene: PIK3CG
UniProt: P48736 (PK3CG_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.12
Assay: Binding constant for PIK3CG kinase domain
Drug: fedratinib
Target: Mitogen-activated protein kinase kinase kinase kinase 2 (Kinase)
Gene: MAP4K2
UniProt: Q12851 (M4K2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.68
Assay: Binding constant for MAP4K2 kinase domain
Drug: fedratinib
Target: Misshapen-like kinase 1 (Kinase)
Gene: MINK1
UniProt: Q8N4C8 (MINK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.05
Assay: Binding constant for MINK kinase domain
Drug: fedratinib
Target: Serine/threonine-protein kinase TBK1 (Kinase)
Gene: TBK1
UniProt: Q9UHD2 (TBK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.04
Assay: Binding constant for TBK1 kinase domain
Drug: fedratinib
Target: Interleukin-1 receptor-associated kinase 4 (Kinase)
Gene: IRAK4
UniProt: Q9NWZ3 (IRAK4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.92
Assay: Binding constant for IRAK4 kinase domain
Drug: fedratinib
Target: Cyclin-dependent kinase 4 (Kinase)
Gene: CDK4
UniProt: P11802 (CDK4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.06
Assay: Binding constant for CDK4-cyclinD3 kinase domain
Drug: fedratinib
Target: Cyclin-dependent kinase-like 2 (Kinase)
Gene: CDKL2
UniProt: Q92772 (CDKL2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.89
Assay: Binding constant for CDKL2 kinase domain
Drug: fedratinib
Target: Ephrin type-B receptor 6 (Kinase)
Gene: EPHB6
UniProt: O15197 (EPHB6_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.52
Assay: Binding constant for EPHB6 kinase domain
Drug: fedratinib
Target: Serine/threonine-protein kinase/endoribonuclease IRE1 (Kinase)
Gene: ERN1
UniProt: O75460 (ERN1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.92
Assay: Binding constant for ERN1 kinase domain
Drug: fedratinib
Target: G protein-coupled receptor kinase 4 (Kinase)
Gene: GRK4
UniProt: P32298 (GRK4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.77
Assay: Binding constant for GRK4 kinase domain
Drug: fedratinib
Target: G protein-coupled receptor kinase 7 (Kinase)
Gene: GRK7
UniProt: Q8WTQ7 (GRK7_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.58
Assay: Binding constant for GRK7 kinase domain
Drug: fedratinib
Target: Homeodomain-interacting protein kinase 2 (Kinase)
Gene: HIPK2
UniProt: Q9H2X6 (HIPK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6
Assay: Binding constant for HIPK2 kinase domain
Drug: fedratinib
Target: Homeodomain-interacting protein kinase 3 (Kinase)
Gene: HIPK3
UniProt: Q9H422 (HIPK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.89
Assay: Binding constant for HIPK3 kinase domain
Drug: fedratinib
Target: Homeodomain-interacting protein kinase 4 (Kinase)
Gene: HIPK4
UniProt: Q8NE63 (HIPK4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.66
Assay: Binding constant for HIPK4 kinase domain
Drug: fedratinib
Target: Serine/threonine-protein kinase ICK (Kinase)
Gene: ICK
UniProt: Q9UPZ9 (ICK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.72
Assay: Binding constant for ICK kinase domain
Drug: fedratinib
Target: Inhibitor of nuclear factor kappa-B kinase subunit alpha (Kinase)
Gene: CHUK
UniProt: O15111 (IKKA_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.08
Assay: Binding constant for IKK-alpha kinase domain
Drug: fedratinib
Target: Interleukin-1 receptor-associated kinase 1 (Kinase)
Gene: IRAK1
UniProt: P51617 (IRAK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.66
Assay: Binding constant for IRAK1 kinase domain
Drug: fedratinib
Target: Mitogen-activated protein kinase kinase kinase 13 (Kinase)
Gene: MAP3K13
UniProt: O43283 (M3K13_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.23
Assay: Binding constant for LZK kinase domain
Drug: fedratinib
Target: Mitogen-activated protein kinase kinase kinase 2 (Kinase)
Gene: MAP3K2
UniProt: Q9Y2U5 (M3K2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.24
Assay: Binding constant for MAP3K2 kinase domain
Drug: fedratinib
Target: Mitogen-activated protein kinase kinase kinase 3 (Kinase)
Gene: MAP3K3
UniProt: Q99759 (M3K3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.89
Assay: Binding constant for MAP3K3 kinase domain
Drug: fedratinib
Target: Serine/threonine-protein kinase 38 (Kinase)
Gene: STK38
UniProt: Q15208 (STK38_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.24
Assay: Binding constant for NDR1 kinase domain
Drug: fedratinib
Target: Serine/threonine-protein kinase NIM1 (Kinase)
Gene: NIM1K
UniProt: Q8IY84 (NIM1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.36
Assay: Binding constant for NIM1 kinase domain
Drug: fedratinib
Target: Serine/threonine-protein kinase RIO2 (Kinase)
Gene: RIOK2
UniProt: Q9BVS4 (RIOK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.58
Assay: Binding constant for RIOK2 kinase domain
Drug: fedratinib
Target: SRSF protein kinase 3 (Kinase)
Gene: SRPK3
UniProt: Q9UPE1 (SRPK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.77
Assay: Binding constant for SRPK3 kinase domain
Drug: fedratinib
Target: STE20/SPS1-related proline-alanine-rich protein kinase (Kinase)
Gene: STK39
UniProt: Q9UEW8 (STK39_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.8
Assay: Binding constant for STK39 kinase domain
Drug: fedratinib
Target: Mitogen-activated protein kinase kinase kinase 7 (Kinase)
Gene: MAP3K7
UniProt: O43318 (M3K7_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.51
Assay: Binding constant for TAK1 kinase domain
Drug: fedratinib
Target: Serine/threonine-protein kinase TAO1 (Kinase)
Gene: TAOK1
UniProt: Q7L7X3 (TAOK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.89
Assay: Binding constant for TAOK1 kinase domain
Drug: fedratinib
Target: Serine/threonine-protein kinase TAO3 (Kinase)
Gene: TAOK3
UniProt: Q9H2K8 (TAOK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.72
Assay: Binding constant for TAOK3 kinase domain
Drug: fedratinib
Target: Serine/threonine-protein kinase ULK1 (Kinase)
Gene: ULK1
UniProt: O75385 (ULK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.57
Assay: Binding constant for ULK1 kinase domain
Drug: fedratinib
Target: Serine/threonine-protein kinase ULK2 (Kinase)
Gene: ULK2
UniProt: Q8IYT8 (ULK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.1
Assay: Binding constant for ULK2 kinase domain
Drug: fedratinib
Target: Serine/threonine-protein kinase ULK3 (Kinase)
Gene: ULK3
UniProt: Q6PHR2 (ULK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.54
Assay: Binding constant for ULK3 kinase domain
Drug: fedratinib
Target: Mitogen-activated protein kinase kinase kinase 19 (Kinase)
Gene: MAP3K19
UniProt: Q56UN5 (M3K19_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.72
Assay: Binding constant for YSK4 kinase domain
Drug: fedratinib
Target: Homeodomain-interacting protein kinase 1 (Kinase)
Gene: HIPK1
UniProt: Q86Z02 (HIPK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.07
Assay: Binding constant for HIPK1 kinase domain
Drug: fedratinib
Target: Serine/threonine-protein kinase PLK2 (Kinase)
Gene: PLK2
UniProt: Q9NYY3 (PLK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.62
Assay: Binding constant for PLK2 kinase domain
Drug: fedratinib
Target: Receptor-interacting serine/threonine-protein kinase 4 (Kinase)
Gene: RIPK4
UniProt: P57078 (RIPK4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.01
Assay: Binding constant for RIPK4 kinase domain
Drug: fedratinib
Target: Uncharacterized serine/threonine-protein kinase SBK3 (Kinase)
Gene: SBK3
UniProt: P0C264 (SBK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.54
Assay: Binding constant for SgK110 kinase domain
Drug: fedratinib
Target: Cyclin-dependent kinase-like 5 (Kinase)
Gene: CDKL5
UniProt: O76039 (CDKL5_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.14
Assay: Binding constant for CDKL5 kinase domain
Drug: fedratinib
Target: Megakaryocyte-associated tyrosine-protein kinase (Kinase)
Gene: MATK
UniProt: P42679 (MATK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.77
Assay: Binding constant for CTK kinase domain
Drug: fedratinib
Target: Phosphatidylinositol 4-kinase beta (Kinase)
Gene: PI4KB
UniProt: Q9UBF8 (PI4KB_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.77
Assay: Binding constant for PIK4CB kinase domain
Drug: fedratinib
Target: Serine/threonine-protein kinase SIK3 (Kinase)
Gene: SIK3
UniProt: Q9Y2K2 (SIK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.72
Assay: Binding constant for QSK kinase domain
Drug: fedratinib
Target: Wee1-like protein kinase 2 (Kinase)
Gene: WEE2
UniProt: P0C1S8 (WEE2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.22
Assay: Binding constant for WEE2 kinase domain
Drug: fedratinib
Target: Bone morphogenetic protein receptor type-1B (Kinase)
Gene: BMPR1B
UniProt: O00238 (BMR1B_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.39
Assay: Binding constant for BMPR1B kinase domain
Drug: fedratinib
Target: Serine/threonine-protein kinase SBK1 (Kinase)
Gene: SBK1
UniProt: Q52WX2 (SBK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.1
Assay: Binding constant for SBK1 kinase domain
Drug: fedratinib
Target: Serine/threonine-protein kinase Nek3 (Kinase)
Gene: NEK3
UniProt: P51956 (NEK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.19
Assay: Binding constant for NEK3 kinase domain
Drug: fedratinib
Target: Peripheral plasma membrane protein CASK (Kinase)
Gene: CASK
UniProt: O14936 (CSKP_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.55
Assay: Binding constant for CASK kinase domain
Drug: fedratinib
Target: Serine/threonine-protein kinase PRP4 homolog (Kinase)
Gene: PRPF4B
UniProt: Q13523 (PRP4B_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.41
Assay: Binding constant for PRP4 kinase domain
Drug: fedratinib
Target: Mitogen-activated protein kinase kinase kinase 12 (Kinase)
Gene: MAP3K12
UniProt: Q12852 (M3K12_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.2
Assay: Binding constant for DLK kinase domain
Drug: fedratinib
Target: Serine/threonine-protein kinase Sgk3 (Kinase)
Gene: SGK3
UniProt: Q96BR1 (SGK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.6
Assay: Binding constant for SGK3 kinase domain
Drug: fedratinib
Target: Eukaryotic translation initiation factor 2-alpha kinase 1 (Kinase)
Gene: EIF2AK1
UniProt: Q9BQI3 (E2AK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6
Assay: Binding constant for EIF2AK1 kinase domain
Drug: fedratinib
Target: Serine/threonine-protein kinase TAO2 (Kinase)
Gene: TAOK2
UniProt: Q9UL54 (TAOK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.12
Assay: Binding constant for TAOK2 kinase domain
Drug: fedratinib
Target: SNF-related serine/threonine-protein kinase (Kinase)
Gene: SNRK
UniProt: Q9NRH2 (SNRK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.64
Assay: Binding constant for SNRK kinase domain
Drug: fedratinib
Target: Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (Kinase)
Gene: PIP4K2C
UniProt: Q8TBX8 (PI42C_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.39
Assay: Binding constant for PIP5K2C kinase domain
Drug: fedratinib
Target: Dual specificity mitogen-activated protein kinase kinase 5 (Kinase)
Gene: MAP2K5
UniProt: Q13163 (MP2K5_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.44
Assay: Binding constant for MEK5 kinase domain
Drug: fedratinib
Target: Serine/threonine-protein kinase Nek11 (Kinase)
Gene: NEK11
UniProt: Q8NG66 (NEK11_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.92
Assay: Binding constant for NEK11 kinase domain
Drug: fedratinib
Target: Myosin light chain kinase 3 (Kinase)
Gene: MYLK3
UniProt: Q32MK0 (MYLK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.01
Assay: Binding constant for MLCK kinase domain
Drug: fedratinib
Target: Leucine-rich repeat serine/threonine-protein kinase 2 (Kinase)
Gene: LRRK2
UniProt: Q5S007 (LRRK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.06
Assay: Binding constant for LRRK2 kinase domain
Drug: fedratinib
Target: Dual serine/threonine and tyrosine protein kinase (Kinase)
Gene: DSTYK
UniProt: Q6XUX3 (DUSTY_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.77
Assay: Binding constant for RIPK5 kinase domain
Drug: fedratinib
Target: Calcium-dependent protein kinase 1 (Kinase)
Gene: CPK1
UniProt: P62344 (CDPK1_PLAF7)
Organism: Plasmodium falciparum
Activity: Kd = 5.92
Assay: Binding constant for PFCDPK1(P.falciparum) kinase domain
Drug: fedratinib
Target: Bromodomain-containing protein 4 (Unclassified)
Gene: BRD4
UniProt: O60885 (BRD4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.79
Assay: Binding affinity to recombinant human His6-TEV protease-tagged BRD4 bromodomain 1 expressed in bacteria by isothermal titration calorimetric method
Drug: fedratinib
Target: Serine/threonine-protein kinase PknB (Kinase)
Gene: pknB
UniProt: P9WI81 (PKNB_MYCTU)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Activity: Kd = 7
Assay: Binding constant for PKNB(M.tuberculosis) kinase domain
Drug: fedratinib
Target: Serine/threonine-protein kinase Nek6 (Kinase)
Gene: NEK6
UniProt: Q9HC98 (NEK6_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.92
Assay: Binding constant for NEK6 kinase domain
Drug: fedratinib
Target: cGMP-dependent protein kinase 1 (Kinase)
Gene: PRKG1
UniProt: Q13976 (KGP1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.42
Assay: Binding constant for PRKG1 kinase domain
Drug: fedratinib
Target: Serine/threonine-protein kinase Nek4 (Kinase)
Gene: NEK4
UniProt: P51957 (NEK4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.8
Assay: Binding constant for NEK4 kinase domain
Drug: fedratinib
Target: Bromodomain testis-specific protein (Unclassified)
Gene: BRDT
UniProt: Q58F21 (BRDT_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.47
Assay: Inhibition of N-terminal 6His-tagged human BRDT bromodomain 1 (21 to 137 residues) expressed in Escherichia coli BL21 (DE3) using biotinylated histone H4 peptide (1 to 21 residues) containing KAc (K5/8/12/16Ac) as substrate by Alpha screen assay
Drug: fedratinib
Target: Serine/threonine-protein kinase Nek1 (Kinase)
Gene: NEK1
UniProt: Q96PY6 (NEK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.47
Assay: Binding constant for NEK1 kinase domain
Drug: fedratinib
Target: Tyrosine-protein kinase JAK3 (Kinase)
Gene: JAK3
UniProt: P52333 (JAK3_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.99
Action type: INHIBITOR
Drug: fedratinib
Target: Tyrosine-protein kinase JAK1 (Kinase)
Gene: JAK1
UniProt: P23458 (JAK1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.97
Action type: INHIBITOR
Drug: fedratinib
Target: Non-receptor tyrosine-protein kinase TYK2 (Kinase)
Gene: TYK2
UniProt: P29597 (TYK2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.39
Action type: INHIBITOR
Drug: fedratinib
Target: Receptor-type tyrosine-protein kinase FLT3 (Kinase)
Gene: FLT3
UniProt: P36888 (FLT3_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7.82
Action type: INHIBITOR
Drug: fedratinib
Target: Tyrosine-protein kinase JAK2 (Kinase)
Gene: JAK2
UniProt: O60674 (JAK2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 8.52
Action type: INHIBITOR
Assay: wild type JAK2