AIM-Harvard/TrialPanorama-filtered huggingface dataset:
Drug: tenapanor
Target: Sodium/hydrogen exchanger 3 (Transporter)
Gene: Slc9a3
UniProt: P26433 (SL9A3_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 8.2
Assay: Inhibition of rat NHE3-mediated sodium-dependant hydrogen ion antiport in Opossum kidney cells preincubated for 60 mins in NaCl-HEPES buffer followed by compound washout with NH4Cl-HEPES buffer containing BCECF-AM dye and subsequent washout with Na+ free HEPES buffer by fluorescence analysis
Drug: tenapanor
Target: Sodium/hydrogen exchanger 3 (Transporter)
Gene: SLC9A3
UniProt: P48764 (SL9A3_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 9.06
Action type: INHIBITOR
Assay: wild type
Drug: trifarotene
Target: Retinoic acid receptor alpha (Nuclear hormone receptor)
Gene: RARA
UniProt: P10276 (RARA_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 6.3
Action type: AGONIST
Drug: trifarotene
Target: Retinoic acid receptor beta (Nuclear hormone receptor)
Gene: RARB
UniProt: P10826 (RARB_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 6.9
Action type: AGONIST
Drug: trifarotene
Target: Retinoic acid receptor gamma (Nuclear hormone receptor)
Gene: RARG
UniProt: P13631 (RARG_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 8.11
Action type: AGONIST
Assay: Mechanism of Action
Drug: lasmiditan
Target: 5-hydroxytryptamine receptor 1F (GPCR)
Gene: HTR1F
UniProt: P30939 (5HT1F_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.65
Action type: AGONIST
Drug: cefiderocol
Target: Peptidoglycan synthase FtsI (Enzyme)
Gene: ftsI
UniProt: P0AD68 (FTSI_ECOLI)
Organism: Escherichia coli (strain K12)
Activity: IC50 = 7.4
Action type: INHIBITOR
Drug: cefiderocol
Target: Penicillin-binding protein 1A (Enzyme)
Gene: mrcA
UniProt: Q07806 (PBPA_PSEAE)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Activity: IC50 = 6.07
Action type: INHIBITOR
Drug: cefiderocol
Target: Penicillin-binding protein 1A (Enzyme)
Gene: mrcA
UniProt: P02918 (PBPA_ECOLI)
Organism: Escherichia coli (strain K12)
Activity: IC50 = 5.48
Action type: INHIBITOR
Drug: cefiderocol
Target: Penicillin-binding protein 1B (Enzyme)
Gene: mrcB
UniProt: P02919 (PBPB_ECOLI)
Organism: Escherichia coli (strain K12)
Activity: IC50 = 5.47
Action type: INHIBITOR
Drug: cefiderocol
Target: Penicillin-binding protein 1A (Enzyme)
Gene: ponA
UniProt: G1C775 (G1C775_ACIBA)
Organism: Acinetobacter baumannii
Activity: IC50 = 5.98
Action type: INHIBITOR
Drug: cefiderocol
Target: Penicillin-binding protein 1B (Enzyme)
Gene: mrcB
UniProt: A6T4V3 (A6T4V3_KLEP7)
Organism: Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
Activity: IC50 = 5.46
Action type: INHIBITOR
Drug: cefiderocol
Target: Peptidoglycan D,D-transpeptidase MrdA (Enzyme)
Gene: mrdA
UniProt: H4I819 (H4I819_ECOLX)
Organism: Escherichia coli DEC1B
Activity: IC50 = 5.66
Action type: INHIBITOR
Drug: cefiderocol
Target: Peptidoglycan D,D-transpeptidase MrdA (Enzyme)
Gene: mrdA
UniProt: A0A0W8ASI8 (A0A0W8ASI8_KLEPN)
Organism: Klebsiella pneumoniae
Activity: IC50 = 7.2
Action type: INHIBITOR
Drug: cefiderocol
Target: Peptidoglycan D,D-transpeptidase FtsI (Enzyme)
Gene: ftsI
UniProt: A6T4M7 (A6T4M7_KLEP7)
Organism: Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
Activity: IC50 = 7.21
Action type: INHIBITOR
Drug: cefiderocol
Target: Peptidoglycan D,D-transpeptidase FtsI (Enzyme)
Gene: ftsI
UniProt: G3XD46 (FTSI_PSEAE)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Activity: IC50 = 7.22
Action type: INHIBITOR
Drug: cefiderocol
Target: Peptidoglycan D,D-transpeptidase FtsI (Enzyme)
Gene: ftsI
UniProt: D0CCM7 (D0CCM7_ACIB2)
Organism: Acinetobacter baumannii (strain ATCC 19606 / DSM 30007 / CIP 70.34 / JCM 6841 / NBRC 109757 / NCIMB 12457 / NCTC 12156 / 81)
Activity: IC50 = 6.17
Action type: INHIBITOR
Drug: cefiderocol
Target: Penicillin-binding protein 4 (Enzyme)
Gene: pbpD_1
UniProt: A0A5E6DR09 (A0A5E6DR09_KLEPN)
Organism: Klebsiella pneumoniae
Activity: IC50 = 5.44
Action type: INHIBITOR
Drug: zanubrutinib
Target: Tyrosine-protein kinase BTK (Kinase)
Gene: BTK
UniProt: Q06187 (BTK_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 9.52
Action type: INHIBITOR
Drug: givosiran
Target: aminolevulinate synthase1 (ALAS1) mRNA (RNA)
Gene: ALAS1
UniProt: P13196 (HEM1_HUMAN)
Organism: Homo sapiens
Action type: ANTISENSE INHIBITOR
Assay: Mechanism of Action
Drug: cenobamate
Target: Gamma-aminobutyric acid receptor subunit alpha-4 (Ion channel)
Gene: GABRA4
UniProt: P48169 (GBRA4_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 4.38
Action type: ALLOSTERIC MODULATOR
Assay: Allosteric modulation of GABA-activated human &alpha;4&beta;3&gamma;2 GABA<sub>A</sub> channels expressed in HEK cells.
Drug: cenobamate
Target: Gamma-aminobutyric acid receptor subunit alpha-6 (Ion channel)
Gene: GABRA6
UniProt: Q16445 (GBRA6_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 4.24
Action type: ALLOSTERIC MODULATOR
Assay: Allosteric modulation of GABA-activated human &alpha;6&beta;3&gamma;2 GABA<sub>A</sub> channels expressed in HEK cells.
Drug: voxelotor
Target: Cytochrome P450 3A4 (Enzyme)
Gene: CYP3A4
UniProt: P08684 (CP3A4_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.9
Action type: INHIBITOR
Assay: Measuring inhibition of CYP3A4 activity using testosterone as substrate.
Drug: voxelotor
Target: Cytochrome P450 2C8 (Enzyme)
Gene: CYP2C8
UniProt: P10632 (CP2C8_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.1
Action type: INHIBITOR
Assay: Measuring inhibition of CYP2C8 activity using paclitaxel as substrate.
Drug: voxelotor
Target: Cytochrome P450 2C9 (Enzyme)
Gene: CYP2C9
UniProt: P11712 (CP2C9_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.07
Action type: INHIBITOR
Assay: Measuring inhibition of CYP2C9 activity using tolbutamide as substrate.
Drug: voxelotor
Target: hemoglobin subunit alpha (Transporter)
Gene: HBA1
UniProt: P69905 (HBA_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 5.09
Action type: INHIBITOR
Assay: Hemoglobin S differs from hemoglobin A only by a single amino acid substitution: a valine replaces a glutamine in the 6th position of the beta chain of globin; forms a reversible covalent bond with the N‐terminal valine of the α chain of HbS.
Drug: golodirsen
Target: exon 53 of dystrophin pre-mRNA (RNA)
Gene: DMD
UniProt: P11532 (DMD_HUMAN)
Organism: Homo sapiens
Action type: ANTISENSE INHIBITOR
Assay: Mechanism of Action
Drug: lumateperone
Target: 5-hydroxytryptamine receptor 1A (GPCR)
Gene: HTR1A
UniProt: P08908 (5HT1A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.83
Assay: Inhibition of human 5HT1A receptor
Drug: lumateperone
Target: 5-hydroxytryptamine receptor 2C (GPCR)
Gene: HTR2C
UniProt: P28335 (5HT2C_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.76
Assay: Displacement of [125]DOI from human recombinant full length 5HT2C receptor expressed in HEK293E cells
Drug: lumateperone
Target: Alpha-1A adrenergic receptor (GPCR)
Gene: ADRA1A
UniProt: P35348 (ADA1A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.14
Assay: Inhibition of adrenergic alpha1A receptor (unknown origin)
Drug: lumateperone
Target: D(4) dopamine receptor (GPCR)
Gene: DRD4
UniProt: P21917 (DRD4_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.97
Assay: Inhibition of human dopamine D4 receptor
Drug: lumateperone
Target: Alpha-1B adrenergic receptor (GPCR)
Gene: ADRA1B
UniProt: P35368 (ADA1B_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.51
Assay: Inhibition of adrenergic alpha1B receptor (unknown origin)
Drug: lumateperone
Target: D(2) dopamine receptor (GPCR)
Gene: Drd2
UniProt: P61169 (DRD2_RAT)
Organism: Rattus norvegicus
Activity: Ki = 7.5
Assay: Displacement of [3H]-N-methylspiperone from rat recombinant dopamine D2 short receptor expressed in CHO cells
Drug: lumateperone
Target: D(1A) dopamine receptor (GPCR)
Gene: DRD1
UniProt: P21728 (DRD1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.38
Action type: ANTAGONIST
Drug: lumateperone
Target: Sodium-dependent serotonin transporter (Transporter)
Gene: SLC6A4
UniProt: P31645 (SC6A4_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.48
Drug: lumateperone
Target: D(2) dopamine receptor (GPCR)
Gene: DRD2
UniProt: P14416 (DRD2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.49
Action type: ANTAGONIST
Drug: lumateperone
Target: 5-hydroxytryptamine receptor 2A (GPCR)
Gene: HTR2A
UniProt: P28223 (5HT2A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 9.26
Action type: ANTAGONIST
Drug: brilliant Blue G
Target: P2X purinoceptor 7 (Ion channel)
Gene: P2RX7
UniProt: Q99572 (P2RX7_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 8
Action type: ANTAGONIST
Drug: brilliant Blue G
Target: Alpha-synuclein (Transporter)
Gene: SNCA
UniProt: P37840 (SYUA_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.27
Assay: Inhibition of wild type alpha-synuclein (unknown origin) aggregation expressed in Escherichia coli BL21 after 30 days by thioflavin T staining-based spectrofluorimetric analysis
Drug: lemborexant
Target: Potassium voltage-gated channel subfamily H member 2 (Ion channel)
Gene: KCNH2
UniProt: Q12809 (KCNH2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.21
Assay: Inhibition of human ERG
Drug: lemborexant
Target: Orexin receptor type 1 (GPCR)
Gene: HCRTR1
UniProt: O43613 (OX1R_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.22
Action type: ANTAGONIST
Drug: lemborexant
Target: Orexin receptor type 2 (GPCR)
Gene: HCRTR2
UniProt: O43614 (OX2R_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.52
Action type: ANTAGONIST
Drug: ubrogepant
Target: Calcitonin gene-related peptide type 1 receptor (GPCR)
Gene: CALCRL
UniProt: Q16602 (CALRL_HUMAN)
Organism: Homo sapiens
Activity: Ki = 10.2
Action type: ANTAGONIST
Drug: romosozumab
Target: Sclerostin (Glycoprotein)
Gene: SOST
UniProt: Q9BQB4 (SOST_HUMAN)
Organism: Homo sapiens
Activity: Kd = 11.7
Action type: BINDING AGENT
Drug: brolucizumab
Target: Vascular endothelial growth factor A (Secreted)
Gene: VEGFA
UniProt: P15692 (VEGFA_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.8
Action type: INHIBITOR
Assay: binds to the three major isoforms of VEGF-A
Drug: luspatercept
Target: Growth/differentiation factor 11 (Cytokine)
Gene: GDF11
UniProt: O95390 (GDF11_HUMAN)
Organism: Homo sapiens
Activity: Kd = 10.13
Action type: BINDING AGENT
Drug: luspatercept
Target: Growth/differentiation factor 8 (Cytokine)
Gene: MSTN
UniProt: O14793 (GDF8_HUMAN)
Organism: Homo sapiens
Activity: Kd = 9.69
Action type: BINDING AGENT
Drug: crizanlizumab
Target: P-selectin (Adhesion)
Gene: SELP
UniProt: P16109 (LYAM3_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.59
Action type: INHIBITOR
Assay: ex-vivo determination published in FDA's Multi-Discipline Review of BLA 761128
Drug: enfortumab vedotin
Target: Tubulin beta (Tumour-associated antigen)
Gene: TUBB|TUBB1|TUBB2A|TUBB2B|TUBB3|TUBB4A|TUBB4B|TUBB6|TUBB8
UniProt: P07437|Q9H4B7|Q13885|Q9BVA1|Q13509|P04350|P68371|Q9BUF5|Q3ZCM7 (TBB5_HUMAN|TBB1_HUMAN|TBB2A_HUMAN|TBB2B_HUMAN|TBB3_HUMAN|TBB4A_HUMAN|TBB4B_HUMAN|TBB6_HUMAN|TBB8_HUMAN)
Organism: Homo sapiens
Action type: BINDING AGENT
Assay: Mechanism of Action
Drug: enfortumab vedotin
Target: Nectin-4 (Tumour-associated antigen)
Gene: NECTIN4
UniProt: Q96NY8 (NECT4_HUMAN)
Organism: Homo sapiens
Activity: Ki = 10.24
Action type: BINDING AGENT
Drug: trastuzumab deruxtecan
Target: Receptor tyrosine-protein kinase erbB-2 (Kinase)
Gene: ERBB2
UniProt: P04626 (ERBB2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.13
Action type: BINDING AGENT
Assay: HER2-specific cell growth inhibition
Drug: trastuzumab deruxtecan
Target: DNA topoisomerase 1 (Enzyme)
Gene: TOP1
UniProt: P11387 (TOP1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7.51
Action type: INHIBITOR
Assay: cell-free DNA topoisomerase I inhibitory activity of DXd component
Drug: botulinum toxin type A
Target: Synaptosomal-associated protein 25 (Cytosolic other)
Gene: SNAP25
UniProt: P60880 (SNP25_HUMAN)
Organism: Homo sapiens
Action type: BLOCKER
Assay: Mechanism of Action
Drug: roxadustat
Target: Alpha-ketoglutarate-dependent dioxygenase FTO (Unclassified)
Gene: FTO
UniProt: Q9C0B1 (FTO_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.01
Assay: Inhibition of human hexahistidine-tagged full-length FTO expressed in Escherichia coli BL21 (DE3) using 3-methylthymidine as substrate assessed as inhibition of 3-methylthymidine conversion to thymidine after 1 hr by liquid chromatographic analysis
Drug: roxadustat
Target: Egl nine homolog 1 (Enzyme)
Gene: EGLN1
UniProt: Q9GZT9 (EGLN1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.54
Action type: INHIBITOR
Drug: roxadustat
Target: Egl nine homolog 2 (Enzyme)
Gene: EGLN2
UniProt: Q96KS0 (EGLN2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.24
Action type: INHIBITOR
Drug: roxadustat
Target: Egl nine homolog 3 (Enzyme)
Gene: EGLN3
UniProt: Q9H6Z9 (EGLN3_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.18
Action type: INHIBITOR
Drug: elexacaftor
Target: Cystic fibrosis transmembrane conductance regulator (Ion channel)
Gene: CFTR
UniProt: P13569 (CFTR_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 7.15
Drug: cepharanthine
Target: Trypanothione reductase (Enzyme)
Gene: TPR
UniProt: P28593 (TYTR_TRYCR)
Organism: Trypanosoma cruzi
Activity: Ki = 5.12
Assay: Inhibition of Trypanosoma cruzi recombinant trypanothione reductase
Drug: cepharanthine
Target: 5'-AMP-activated protein kinase catalytic subunit alpha-1 (Kinase)
Gene: PRKAA1
UniProt: Q13131 (AAPK1_HUMAN)
Organism: Homo sapiens
Action type: INHIBITOR
Assay: Mechanism of Action
Drug: cepharanthine
Target: Nuclear factor NF-kappa-B p105 subunit (Cytosolic other)
Gene: NFKB1
UniProt: P19838 (NFKB1_HUMAN)
Organism: Homo sapiens
Action type: INHIBITOR
Assay: Mechanism of Action
Drug: remdesivir
Target: Replicase polyprotein 1ab (Enzyme)
Gene: REP
UniProt: P0DTD1 (R1AB_SARS2)
Organism: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2)
Activity: EC50 = 8.52
Action type: INHIBITOR
Assay: SARS-CoV-2 RNA-dependent RNA polymerase
Drug: mefuparib
Target: Poly [ADP-ribose] polymerase 2 (Enzyme)
Gene: PARP2
UniProt: Q9UGN5 (PARP2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 8.72
Action type: INHIBITOR
Assay: biotinylated [NAD+]-based luminescence assays
Drug: mefuparib
Target: Poly [ADP-ribose] polymerase 1 (Enzyme)
Gene: PARP1
UniProt: P09874 (PARP1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 8.49
Action type: INHIBITOR
Assay: biotinylated [NAD+]-based luminescence assays
Drug: avapritinib
Target: Mast/stem cell growth factor receptor Kit (Kinase)
Gene: Kit
UniProt: P05532 (KIT_MOUSE)
Organism: Mus musculus
Activity: IC50 = 7.66
Action type: INHIBITOR
Assay: Inhibition of KIT D816Y mutant autophosphorylation in P815 cell line
Drug: avapritinib
Target: Mast/stem cell growth factor receptor Kit (Kinase)
Gene: KIT
UniProt: P10721 (KIT_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 9.57
Action type: INHIBITOR
Assay: KIT D816V (exon 17)
Drug: avapritinib
Target: Platelet-derived growth factor receptor alpha (Kinase)
Gene: PDGFRA
UniProt: P16234 (PGFRA_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 9.62
Action type: INHIBITOR
Assay: PDGFRA D842V (exon 18) mutant
Drug: tazemetostat
Target: Polycomb protein EED (Unclassified)
Gene: EED
UniProt: O75530 (EED_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 8.7
Assay: Inhibition of recombinant N-terminal GST-tagged EED (76 to 441 residues) (unknown origin) expressed in Escherichia coli BL21-CodonPlus(DE3)-RIL assessed as reduction in SAH production using H3[21-44,K27Me0) peptide as substrate measured after 20 mins by LC/MS/MS method
Drug: tazemetostat
Target: Histone-lysine N-methyltransferase EZH1 (Enzyme)
Gene: EZH1
UniProt: Q92800 (EZH1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.41
Action type: INHIBITOR
Drug: tazemetostat
Target: Histone-lysine N-methyltransferase EZH2 (Enzyme)
Gene: EZH2
UniProt: Q15910 (EZH2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7.96
Action type: INHIBITOR
Assay: Mechanism of Action
Drug: rimegepant
Target: Calcitonin gene-related peptide type 1 receptor (GPCR)
Gene: CALCRL
UniProt: Q16602 (CALRL_HUMAN)
Organism: Homo sapiens
Activity: Ki = 10.56
Action type: ANTAGONIST
Drug: bempedoic acid
Target: ATP-citrate synthase (Enzyme)
Gene: ACLY
UniProt: P53396 (ACLY_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.69
Action type: INHIBITOR
Assay: Inhibition of ACL by ETC-1002-CoA
Drug: ozanimod
Target: Sphingosine 1-phosphate receptor 4 (GPCR)
Gene: S1PR4
UniProt: O95977 (S1PR4_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 5.38
Assay: Agonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrs
Drug: ozanimod
Target: Sphingosine 1-phosphate receptor 3 (GPCR)
Gene: S1PR3
UniProt: Q99500 (S1PR3_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 5
Assay: Agonist activity at human S1P3 Galpha5 expressed in NFAT-bla HEK293T cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrs
Drug: ozanimod
Target: Sphingosine 1-phosphate receptor 2 (GPCR)
Gene: S1PR2
UniProt: O95136 (S1PR2_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 5.02
Assay: Agonist activity at human S1P2 expressed in CRE-bla CHOK1 cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrs
Drug: ozanimod
Target: Sphingosine 1-phosphate receptor 1 (GPCR)
Gene: S1PR1
UniProt: P21453 (S1PR1_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 9.39
Action type: AGONIST
Drug: ozanimod
Target: Sphingosine 1-phosphate receptor 5 (GPCR)
Gene: S1PR5
UniProt: Q9H228 (S1PR5_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 7.96
Action type: AGONIST
Drug: osilodrostat
Target: Aromatase (Enzyme)
Gene: CYP19A1
UniProt: P11511 (CP19A_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.07
Assay: Inhibition of CYP19 (unknown origin)
Drug: osilodrostat
Target: Cytochrome P450 11B2, mitochondrial (Enzyme)
Gene: Cyp11b2
UniProt: P15539 (C11B2_MOUSE)
Organism: Mus musculus
Activity: IC50 = 6.68
Assay: Inhibition of mouse CYP11B2 expressed in renal leiomyoblastoma cells
Drug: osilodrostat
Target: Cytochrome P450 11B1, mitochondrial (Enzyme)
Gene: Cyp11b1
UniProt: P15393 (C11B1_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 6.3
Assay: Inhibition of rat recombinant CYP11B1 using 11-deoxycortisol as substrate by cell-based assay
Drug: osilodrostat
Target: Cytochrome P450 11B2, mitochondrial (Enzyme)
Gene: Cyp11b2
UniProt: P30099 (C11B2_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 6.96
Assay: Inhibition of rat recombinant CYP11B2 using 11-deoxycorticosterone as substrate by cell-based assay
Drug: osilodrostat
Target: Cytochrome P450 11B2, mitochondrial (Enzyme)
Gene: CYP11B2
UniProt: P19099 (C11B2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 9.15
Action type: INHIBITOR
Drug: osilodrostat
Target: Cytochrome P450 11B1, mitochondrial (Enzyme)
Gene: CYP11B1
UniProt: P15538 (C11B1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 8.6
Action type: INHIBITOR
Drug: isatuximab
Target: Lymphocyte differentiation antigen CD38 (Tumour-associated antigen)
Gene: CD38
UniProt: P28907 (CD38_HUMAN)
Organism: Homo sapiens
Activity: Kd = 9.7
Action type: BINDING AGENT
Drug: eptinezumab
Target: Calcitonin gene-related peptide 1 (GPCR)
Gene: CALCA
UniProt: P06881 (CALCA_HUMAN)
Organism: Homo sapiens
Activity: Kd = 10.82
Action type: BINDING AGENT
Drug: eptinezumab
Target: Calcitonin gene-related peptide 2 (GPCR)
Gene: CALCB
UniProt: P10092 (CALCB_HUMAN)
Organism: Homo sapiens
Activity: Kd = 10.24
Action type: BINDING AGENT
Drug: teprotumumab
Target: Insulin-like growth factor 1 receptor (Kinase)
Gene: IGF1R
UniProt: P08069 (IGF1R_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 9
Action type: ANTAGONIST
Drug: selumetinib
Target: Epidermal growth factor receptor (Kinase)
Gene: EGFR
UniProt: P00533 (EGFR_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.66
Assay: Binding constant for EGFR(T790M) kinase domain
Drug: selumetinib
Target: Dual specificity mitogen-activated protein kinase kinase 1 (Kinase)
Gene: MAP2K1
UniProt: Q02750 (MP2K1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7.85
Action type: INHIBITOR
Drug: selumetinib
Target: Dual specificity mitogen-activated protein kinase kinase 2 (Kinase)
Gene: MAP2K2
UniProt: P36507 (MP2K2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7.85
Action type: INHIBITOR
Drug: tucatinib
Target: Epidermal growth factor receptor (Kinase)
Gene: EGFR
UniProt: P00533 (EGFR_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.35
Action type: INHIBITOR
Assay: Inhibition of enzyme activity in a biochemical assay.
Drug: tucatinib
Target: Receptor tyrosine-protein kinase erbB-4 (Kinase)
Gene: ERBB4
UniProt: Q15303 (ERBB4_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.5
Action type: INHIBITOR
Drug: tucatinib
Target: ERBB2/ERBB3 (Kinase)
Gene: ERBB2|ERBB3
UniProt: P04626|P21860 (ERBB2_HUMAN|ERBB3_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 8.16
Action type: INHIBITOR
Drug: pemigatinib
Target: Fibroblast growth factor receptor 4 (Kinase)
Gene: FGFR4
UniProt: P22455 (FGFR4_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7.52
Action type: INHIBITOR
Drug: pemigatinib
Target: Fibroblast growth factor receptor 3 (Kinase)
Gene: FGFR3
UniProt: P22607 (FGFR3_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 9
Action type: INHIBITOR
Drug: pemigatinib
Target: Fibroblast growth factor receptor 1 (Kinase)
Gene: FGFR1
UniProt: P11362 (FGFR1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 9.4
Action type: INHIBITOR
Drug: pemigatinib
Target: Fibroblast growth factor receptor 2 (Kinase)
Gene: FGFR2
UniProt: P21802 (FGFR2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 9.3
Action type: INHIBITOR
Drug: sacituzumab govitecan
Target: IgG receptor FcRn large subunit p51 (Membrane receptor)
Gene: FCGRT
UniProt: P55899 (FCGRN_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.71
Action type: ANTIBODY BINDING
Drug: sacituzumab govitecan
Target: DNA topoisomerase 1 (Enzyme)
Gene: TOP1
UniProt: P11387 (TOP1_HUMAN)
Organism: Homo sapiens
Action type: BINDING AGENT
Assay: SN-38 binds to topoisomerase I and induces DNA damage
Drug: sacituzumab govitecan
Target: Tumor-associated calcium signal transducer 2 (Tumour-associated antigen)
Gene: TACSTD2
UniProt: P09758 (TACD2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 9.58
Action type: ANTIBODY BINDING
Drug: capmatinib
Target: Hepatocyte growth factor receptor (Kinase)
Gene: MET
UniProt: P08581 (MET_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 9.88
Action type: INHIBITOR
Drug: selpercatinib
Target: Aurora kinase B (Kinase)
Gene: AURKB
UniProt: Q96GD4 (AURKB_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7.1
Action type: INHIBITOR
Assay: In vitro kinase profiling assays
Drug: selpercatinib
Target: Proto-oncogene tyrosine-protein kinase receptor Ret (Kinase)
Gene: RET
UniProt: P07949 (RET_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7.76
Action type: INHIBITOR
Assay: In vitro kinase profiling assays
Drug: ripretinib
Target: Platelet-derived growth factor receptor beta (Kinase)
Gene: PDGFRB
UniProt: P09619 (PGFRB_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 8.05
Action type: INHIBITOR
Assay: In vitro kinase binding assay
Drug: ripretinib
Target: Vascular endothelial growth factor receptor 2 (Kinase)
Gene: KDR
UniProt: P35968 (VGFR2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 8.47
Action type: INHIBITOR
Assay: In vitro kinase binding assay
Drug: ripretinib
Target: Macrophage colony-stimulating factor 1 receptor (Kinase)
Gene: CSF1R
UniProt: P07333 (CSF1R_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.91
Action type: INHIBITOR
Assay: In vitro kinase binding assay
Drug: ripretinib
Target: Angiopoietin-1 receptor (Kinase)
Gene: TEK
UniProt: Q02763 (TIE2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 8.27
Action type: INHIBITOR
Assay: In vitro kinase binding assay
Drug: ripretinib
Target: Mast/stem cell growth factor receptor Kit (Kinase)
Gene: KIT
UniProt: P10721 (KIT_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 8.52
Action type: INHIBITOR
Assay: Wild type kinase
Drug: ripretinib
Target: Platelet-derived growth factor receptor alpha (Kinase)
Gene: PDGFRA
UniProt: P16234 (PGFRA_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 8.44
Action type: INHIBITOR
Assay: Wild type kinase