AIM-Harvard/TrialPanorama-filtered huggingface dataset:
Drug: midostaurin
Target: Calcium-dependent protein kinase 1 (Kinase)
Gene: CPK1
UniProt: P62344 (CDPK1_PLAF7)
Organism: Plasmodium falciparum
Activity: Kd = 6.02
Assay: Binding constant for PFCDPK1(P.falciparum) kinase domain
Drug: midostaurin
Target: cGMP-dependent protein kinase 1 (Kinase)
Gene: PRKG1
UniProt: Q13976 (KGP1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.6
Assay: Binding constant for PRKG1 kinase domain
Drug: midostaurin
Target: cAMP-dependent protein kinase catalytic subunit PRKX (Kinase)
Gene: PRKX
UniProt: P51817 (PRKX_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.02
Assay: Binding constant for full-length PRKX
Drug: midostaurin
Target: Receptor-type tyrosine-protein kinase FLT3 (Kinase)
Gene: FLT3
UniProt: P36888 (FLT3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.96
Action type: INHIBITOR
Drug: abaloparatide
Target: Parathyroid hormone/parathyroid hormone-related peptide receptor (GPCR)
Gene: PTH1R
UniProt: Q03431 (PTH1R_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 9.7
Action type: AGONIST
Drug: brigatinib
Target: Epidermal growth factor receptor (Kinase)
Gene: EGFR
UniProt: P00533 (EGFR_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7.174
Action type: INHIBITOR
Drug: brigatinib
Target: Receptor-type tyrosine-protein kinase FLT3 (Kinase)
Gene: FLT3
UniProt: P36888 (FLT3_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 8.678
Action type: INHIBITOR
Drug: brigatinib
Target: Insulin-like growth factor 1 receptor (Kinase)
Gene: IGF1R
UniProt: P08069 (IGF1R_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7.137
Action type: INHIBITOR
Drug: brigatinib
Target: Insulin receptor (Kinase)
Gene: INSR
UniProt: P06213 (INSR_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.796
Action type: INHIBITOR
Drug: brigatinib
Target: Proto-oncogene tyrosine-protein kinase ROS (Kinase)
Gene: ROS1
UniProt: P08922 (ROS1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 8.721
Action type: INHIBITOR
Drug: brigatinib
Target: ALK tyrosine kinase receptor (Kinase)
Gene: ALK
UniProt: Q9UM73 (ALK_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 9.222
Action type: INHIBITOR
Drug: durvalumab
Target: Programmed cell death 1 ligand 1 (CD molecules)
Gene: CD274
UniProt: Q9NZQ7 (PD1L1_HUMAN)
Organism: Homo sapiens
Action type: ANTIBODY BINDING
Drug: cenegermin
Target: High affinity nerve growth factor receptor (Kinase)
Gene: NTRK1
UniProt: P04629 (NTRK1_HUMAN)
Organism: Homo sapiens
Action type: AGONIST
Drug: cenegermin
Target: Tumor necrosis factor receptor superfamily member 16 (Membrane receptor)
Gene: NGFR
UniProt: P08138 (TNR16_HUMAN)
Organism: Homo sapiens
Action type: AGONIST
Drug: sarilumab
Target: Interleukin-6 receptor (Membrane receptor)
Gene: IL6R|IL6ST
UniProt: P08887|P40189 (IL6RA_HUMAN|IL6RB_HUMAN)
Organism: Homo sapiens
Activity: Kd = 11.1
Action type: ANTIBODY BINDING
Drug: evogliptin
Target: Potassium voltage-gated channel subfamily H member 2 (Ion channel)
Gene: KCNH2
UniProt: Q12809 (KCNH2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.1
Assay: Inhibition of human ERG by patch clamp method
Drug: evogliptin
Target: Dipeptidyl peptidase 4 (Enzyme)
Gene: DPP4
UniProt: P27487 (DPP4_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 9.046
Action type: INHIBITOR
Drug: polmacoxib
Target: Prostaglandin G/H synthase 1 (Enzyme)
Gene: Ptgs1
UniProt: P22437 (PGH1_MOUSE)
Organism: Mus musculus
Activity: IC50 = 8.52
Assay: Inhibition of COX-1 in LPS-induced mouse peritoneal macrophages
Drug: polmacoxib
Target: Prostaglandin G/H synthase 1 (Enzyme)
Gene: PTGS1
UniProt: P23219 (PGH1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.081
Action type: INHIBITOR
Drug: polmacoxib
Target: Prostaglandin G/H synthase 2 (Enzyme)
Gene: PTGS2
UniProt: P35354 (PGH2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 8.081
Action type: INHIBITOR
Drug: betrixaban
Target: Potassium voltage-gated channel subfamily H member 2 (Ion channel)
Gene: KCNH2
UniProt: Q12809 (KCNH2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.75
Assay: Binding affinity to human ERG
Drug: betrixaban
Target: Prothrombin (Enzyme)
Gene: F2
UniProt: P00734 (THRB_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.75
Assay: Inhibition of human thrombin using acromogenic substrate S-2238 preincubated for 30 mins before substrate addition measured after 20 mins by spectrophotometry
Drug: betrixaban
Target: Coagulation factor X (Enzyme)
Gene: F10
UniProt: P00742 (FA10_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 8.824
Action type: INHIBITOR
Drug: voxilaprevir
Target: Genome polyprotein (Polyprotein)
UniProt: P26663 (POLG_HCVBK)
Organism: Hepatitis C virus genotype 1b (isolate BK)
Activity: Ki = 10.42
Action type: INHIBITOR
Drug: voxilaprevir
Target: Genome polyprotein (Polyprotein)
UniProt: Q81495 (POLG_HCVK3)
Organism: Hepatitis C virus genotype 3a (isolate k3a) (HCV)
Activity: Ki = 10.18
Action type: INHIBITOR
Drug: pibrentasvir
Target: Nonstructural protein 5A (Unclassified)
Gene: NS5A
UniProt: Q5L478 (Q5L478_9HEPC)
Organism: Hepatitis C virus
Activity: EC50 = 10.19
Assay: Inhibition of NS5A in HuH7 cell infected HCV genotype 1a H77 assessed as decrease in viral replication after 3 days in presence of 40% human plasma by luciferase reporter gene assay
Drug: pibrentasvir
Target: Genome polyprotein [Cleaved into: Core protein p21 (Unclassified)
UniProt: Q9WMX2 (POLG_HCVCO)
Organism: Hepatitis C virus genotype 1b
Activity: EC50 = 9.7
Assay: Inhibition of NS5A in HuH7 cell infected HCV genotype 1b Con1 assessed as decrease in viral replication after 3 days in presence of 40% human plasma by luciferase reporter gene assay
Drug: corifollitropin alfa
Target: Follicle-stimulating hormone receptor (GPCR)
Gene: FSHR
UniProt: P23945 (FSHR_HUMAN)
Organism: Homo sapiens
Action type: AGONIST
Drug: guselkumab
Target: Interleukin-23 (Cytokine)
Gene: IL12B|IL23A
UniProt: P29460|Q9NPF7 (IL12B_HUMAN|IL23A_HUMAN)
Organism: Homo sapiens
Action type: ANTIBODY BINDING
Drug: inotuzumab ozogamicin
Target: B-cell receptor CD22 (Membrane receptor)
Gene: CD22
UniProt: P20273 (CD22_HUMAN)
Organism: Homo sapiens
Activity: Kd = 9.7
Action type: ANTIBODY BINDING
Drug: pemafibrate
Target: Peroxisome proliferator-activated receptor gamma (Nuclear hormone receptor)
Gene: PPARG
UniProt: P37231 (PPARG_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 5.959
Action type: AGONIST
Drug: pemafibrate
Target: Peroxisome proliferator-activated receptor delta (Nuclear hormone receptor)
Gene: PPARD
UniProt: Q03181 (PPARD_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 5.801
Action type: AGONIST
Drug: pemafibrate
Target: Peroxisome proliferator-activated receptor alpha (Nuclear hormone receptor)
Gene: PPARA
UniProt: Q07869 (PPARA_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 9
Action type: AGONIST
Drug: imrecoxib
Target: Prostaglandin G/H synthase 2 (Enzyme)
Gene: Ptgs2
UniProt: Q05769 (PGH2_MOUSE)
Organism: Mus musculus
Activity: IC50 = 7.75
Assay: Inhibition of COX2 in mouse peritoneal macrophages
Drug: imrecoxib
Target: Prostaglandin G/H synthase 1 (Enzyme)
Gene: Ptgs1
UniProt: P22437 (PGH1_MOUSE)
Organism: Mus musculus
Activity: IC50 = 6.94
Assay: Inhibition of COX1 in mouse peritoneal macrophages
Drug: imrecoxib
Target: Prostaglandin G/H synthase 2 (Enzyme)
Gene: PTGS2
UniProt: P35354 (PGH2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7.824
Action type: INHIBITOR
Drug: enasidenib
Target: Isocitrate dehydrogenase [NADP] cytoplasmic (Enzyme)
Gene: IDH1
UniProt: O75874 (IDHC_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.3
Assay: Inhibition of full length C-terminal His8 tagged IDH1 R132H mutant (1 to 414 residues) (unknown origin) homodimer expressed in Escherichia coli BE3 cells assessed as reduction in NADPH consumption using alpha-ketoglutarate as substrate after 60 mins by Diaphorase/Resazurin dye based fluorescence assay
Drug: enasidenib
Target: Isocitrate dehydrogenase [NADP], mitochondrial (Enzyme)
Gene: IDH2
UniProt: P48735 (IDHP_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7
Action type: INHIBITOR
Assay: inhibition of 2HG production by the IDH2(R140Q) homodimer
Drug: neratinib
Target: Tyrosine-protein kinase JAK3 (Kinase)
Gene: JAK3
UniProt: P52333 (JAK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.7
Assay: Binding constant for JAK3(JH1domain-catalytic) kinase domain
Drug: neratinib
Target: Macrophage-stimulating protein receptor (Kinase)
Gene: MST1R
UniProt: Q04912 (RON_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.08
Assay: Binding constant for MST1R kinase domain
Drug: neratinib
Target: Tyrosine-protein kinase ABL1 (Kinase)
Gene: ABL1
UniProt: P00519 (ABL1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.22
Assay: Binding constant for ABL1(Q252H)-phosphorylated kinase domain
Drug: neratinib
Target: Proto-oncogene tyrosine-protein kinase Src (Kinase)
Gene: SRC
UniProt: P12931 (SRC_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.39
Assay: Binding constant for SRC kinase domain
Drug: neratinib
Target: Tyrosine-protein kinase Lck (Kinase)
Gene: LCK
UniProt: P06239 (LCK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.92
Assay: Binding constant for LCK kinase domain
Drug: neratinib
Target: Tyrosine-protein kinase Yes (Kinase)
Gene: YES1
UniProt: P07947 (YES_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.62
Assay: Binding constant for YES kinase domain
Drug: neratinib
Target: Tyrosine-protein kinase Fyn (Kinase)
Gene: FYN
UniProt: P06241 (FYN_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.19
Assay: Binding constant for FYN kinase domain
Drug: neratinib
Target: Receptor-type tyrosine-protein kinase FLT3 (Kinase)
Gene: FLT3
UniProt: P36888 (FLT3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.51
Assay: Binding constant for FLT3(D835Y) kinase domain
Drug: neratinib
Target: Vascular endothelial growth factor receptor 2 (Kinase)
Gene: KDR
UniProt: P35968 (VGFR2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.07
Assay: Inhibition of human VEGFR2 in presence of 1 uM ATP
Drug: neratinib
Target: Macrophage colony-stimulating factor 1 receptor (Kinase)
Gene: CSF1R
UniProt: P07333 (CSF1R_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.17
Assay: Binding constant for CSF1R kinase domain
Drug: neratinib
Target: Insulin receptor (Kinase)
Gene: INSR
UniProt: P06213 (INSR_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.52
Assay: Binding constant for INSR kinase domain
Drug: neratinib
Target: Mitogen-activated protein kinase 8 (Kinase)
Gene: MAPK8
UniProt: P45983 (MK08_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.48
Assay: Binding constant for JNK1 kinase domain
Drug: neratinib
Target: Focal adhesion kinase 1 (Kinase)
Gene: PTK2
UniProt: Q05397 (FAK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.72
Assay: Binding constant for FAK kinase domain
Drug: neratinib
Target: Tyrosine-protein kinase HCK (Kinase)
Gene: HCK
UniProt: P08631 (HCK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.31
Assay: Binding constant for HCK kinase domain
Drug: neratinib
Target: Mitogen-activated protein kinase 10 (Kinase)
Gene: MAPK10
UniProt: P53779 (MK10_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.6
Assay: Binding constant for JNK3 kinase domain
Drug: neratinib
Target: Tyrosine-protein kinase SYK (Kinase)
Gene: SYK
UniProt: P43405 (KSYK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.29
Assay: Binding constant for SYK kinase domain
Drug: neratinib
Target: Tyrosine-protein kinase CSK (Kinase)
Gene: CSK
UniProt: P41240 (CSK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.26
Assay: Binding constant for CSK kinase domain
Drug: neratinib
Target: Angiopoietin-1 receptor (Kinase)
Gene: TEK
UniProt: Q02763 (TIE2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.52
Assay: Binding constant for TIE2 kinase domain
Drug: neratinib
Target: Hepatocyte growth factor receptor (Kinase)
Gene: MET
UniProt: P08581 (MET_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.4
Assay: Binding constant for MET kinase domain
Drug: neratinib
Target: Tyrosine-protein kinase Lyn (Kinase)
Gene: LYN
UniProt: P07948 (LYN_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.09
Assay: Binding constant for LYN kinase domain
Drug: neratinib
Target: Serine/threonine-protein kinase Nek2 (Kinase)
Gene: NEK2
UniProt: P51955 (NEK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.6
Assay: Binding constant for NEK2 kinase domain
Drug: neratinib
Target: Ribosomal protein S6 kinase alpha-2 (Kinase)
Gene: RPS6KA2
UniProt: Q15349 (KS6A2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.39
Assay: Binding constant for RSK3(Kin.Dom.1-N-terminal) kinase domain
Drug: neratinib
Target: Serine/threonine-protein kinase 17B (Kinase)
Gene: STK17B
UniProt: O94768 (ST17B_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.96
Assay: Binding constant for DRAK2 kinase domain
Drug: neratinib
Target: Serine/threonine-protein kinase 10 (Kinase)
Gene: STK10
UniProt: O94804 (STK10_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.89
Assay: Binding constant for LOK kinase domain
Drug: neratinib
Target: Tyrosine-protein kinase Fer (Kinase)
Gene: FER
UniProt: P16591 (FER_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.29
Assay: Binding constant for FER kinase domain
Drug: neratinib
Target: Serine/threonine-protein kinase 17A (Kinase)
Gene: STK17A
UniProt: Q9UEE5 (ST17A_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.47
Assay: Binding constant for DRAK1 kinase domain
Drug: neratinib
Target: TRAF2 and NCK-interacting protein kinase (Kinase)
Gene: TNIK
UniProt: Q9UKE5 (TNIK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.85
Assay: Binding constant for TNIK kinase domain
Drug: neratinib
Target: Casein kinase I isoform epsilon (Kinase)
Gene: CSNK1E
UniProt: P49674 (KC1E_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.54
Assay: Binding constant for CSNK1E kinase domain
Drug: neratinib
Target: Tyrosine-protein kinase Fgr (Kinase)
Gene: FGR
UniProt: P09769 (FGR_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.72
Assay: Binding constant for FGR kinase domain
Drug: neratinib
Target: Serine/threonine-protein kinase 36 (Kinase)
Gene: STK36
UniProt: Q9NRP7 (STK36_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.28
Assay: Binding constant for STK36 kinase domain
Drug: neratinib
Target: Mitogen-activated protein kinase kinase kinase kinase 5 (Kinase)
Gene: MAP4K5
UniProt: Q9Y4K4 (M4K5_HUMAN)
Organism: Homo sapiens
Activity: Kd = 9.19
Assay: Binding constant for MAP4K5 kinase domain
Drug: neratinib
Target: Mitogen-activated protein kinase kinase kinase 4 (Kinase)
Gene: MAP3K4
UniProt: Q9Y6R4 (M3K4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.41
Assay: Binding constant for MAP3K4 kinase domain
Drug: neratinib
Target: Cyclin-G-associated kinase (Kinase)
Gene: GAK
UniProt: O14976 (GAK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.6
Assay: Binding constant for GAK kinase domain
Drug: neratinib
Target: Calcium/calmodulin-dependent protein kinase type 1D (Kinase)
Gene: CAMK1D
UniProt: Q8IU85 (KCC1D_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.25
Assay: Binding constant for CAMK1D kinase domain
Drug: neratinib
Target: Cyclin-dependent kinase 16 (Kinase)
Gene: CDK16
UniProt: Q00536 (CDK16_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.64
Assay: Binding constant for PCTK1 kinase domain
Drug: neratinib
Target: Serine/threonine-protein kinase 4 (Kinase)
Gene: STK4
UniProt: Q13043 (STK4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.57
Assay: Binding constant for MST1 kinase domain
Drug: neratinib
Target: Activated CDC42 kinase 1 (Kinase)
Gene: TNK2
UniProt: Q07912 (ACK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.17
Assay: Binding constant for TNK2 kinase domain
Drug: neratinib
Target: STE20-like serine/threonine-protein kinase (Kinase)
Gene: SLK
UniProt: Q9H2G2 (SLK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.18
Assay: Binding constant for SLK kinase domain
Drug: neratinib
Target: Dual specificity mitogen-activated protein kinase kinase 7 (Kinase)
Gene: MAP2K7
UniProt: O14733 (MP2K7_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.28
Assay: Binding constant for MKK7 kinase domain
Drug: neratinib
Target: Dual specificity mitogen-activated protein kinase kinase 1 (Kinase)
Gene: MAP2K1
UniProt: Q02750 (MP2K1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.85
Assay: Binding constant for MEK1 kinase domain
Drug: neratinib
Target: Dual specificity mitogen-activated protein kinase kinase 2 (Kinase)
Gene: MAP2K2
UniProt: P36507 (MP2K2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.59
Assay: Binding constant for MEK2 kinase domain
Drug: neratinib
Target: Tyrosine-protein kinase BTK (Kinase)
Gene: BTK
UniProt: Q06187 (BTK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.8
Assay: Binding constant for BTK kinase domain
Drug: neratinib
Target: Tyrosine-protein kinase receptor UFO (Kinase)
Gene: AXL
UniProt: P30530 (UFO_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.72
Assay: Binding constant for AXL kinase domain
Drug: neratinib
Target: Cyclin-dependent kinase 7 (Kinase)
Gene: CDK7
UniProt: P50613 (CDK7_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.29
Assay: Binding constant for CDK7 kinase domain
Drug: neratinib
Target: Serine/threonine-protein kinase D1 (Kinase)
Gene: PRKD1
UniProt: Q15139 (KPCD1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.09
Assay: Binding constant for PRKD1 kinase domain
Drug: neratinib
Target: Serine/threonine-protein kinase 3 (Kinase)
Gene: STK3
UniProt: Q13188 (STK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.24
Assay: Binding constant for MST2 kinase domain
Drug: neratinib
Target: NUAK family SNF1-like kinase 2 (Kinase)
Gene: NUAK2
UniProt: Q9H093 (NUAK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.85
Assay: Binding constant for SNARK kinase domain
Drug: neratinib
Target: Serine/threonine-protein kinase Chk1 (Kinase)
Gene: CHEK1
UniProt: O14757 (CHK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.24
Assay: Binding constant for CHEK1 kinase domain
Drug: neratinib
Target: Wee1-like protein kinase (Kinase)
Gene: WEE1
UniProt: P30291 (WEE1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.39
Assay: Binding constant for WEE1 kinase domain
Drug: neratinib
Target: Serine/threonine-protein kinase 25 (Kinase)
Gene: STK25
UniProt: O00506 (STK25_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.92
Assay: Binding constant for YSK1 kinase domain
Drug: neratinib
Target: Mitogen-activated protein kinase kinase kinase MLT (Kinase)
Gene: ZAK
UniProt: Q9NYL2 (MLTK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.82
Assay: Binding constant for ZAK kinase domain
Drug: neratinib
Target: Protein-tyrosine kinase 2-beta (Kinase)
Gene: PTK2B
UniProt: Q14289 (FAK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.1
Assay: Binding constant for PYK2 kinase domain
Drug: neratinib
Target: Casein kinase I isoform gamma-2 (Kinase)
Gene: CSNK1G2
UniProt: P78368 (KC1G2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.18
Assay: Binding constant for CSNK1G2 kinase domain
Drug: neratinib
Target: Casein kinase I isoform gamma-3 (Kinase)
Gene: CSNK1G3
UniProt: Q9Y6M4 (KC1G3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.11
Assay: Binding constant for CSNK1G3 kinase domain
Drug: neratinib
Target: Tyrosine-protein kinase receptor Tie-1 (Kinase)
Gene: TIE1
UniProt: P35590 (TIE1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.41
Assay: Binding constant for TIE1 kinase domain
Drug: neratinib
Target: Tyrosine-protein kinase TXK (Kinase)
Gene: TXK
UniProt: P42681 (TXK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.32
Assay: Binding constant for TXK kinase domain
Drug: neratinib
Target: Maternal embryonic leucine zipper kinase (Kinase)
Gene: MELK
UniProt: Q14680 (MELK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.8
Assay: Binding constant for MELK kinase domain
Drug: neratinib
Target: Serine/threonine-protein kinase 26 (Kinase)
Gene: STK26
UniProt: Q9P289 (STK26_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.13
Assay: Binding constant for MST4 kinase domain
Drug: neratinib
Target: Eukaryotic translation initiation factor 2-alpha kinase 4 (Kinase)
Gene: EIF2AK4
UniProt: Q9P2K8 (E2AK4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.02
Assay: Binding constant for GCN2(Kin.Dom.2,S808G) kinase domain
Drug: neratinib
Target: Insulin receptor-related protein (Kinase)
Gene: INSRR
UniProt: P14616 (INSRR_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.34
Assay: Binding constant for INSRR kinase domain
Drug: neratinib
Target: Serine/threonine-protein kinase SIK2 (Kinase)
Gene: SIK2
UniProt: Q9H0K1 (SIK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.48
Assay: Binding constant for SIK2 kinase domain
Drug: neratinib
Target: Serine/threonine-protein kinase 33 (Kinase)
Gene: STK33
UniProt: Q9BYT3 (STK33_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.03
Assay: Binding constant for STK33 kinase domain
Drug: neratinib
Target: Mitogen-activated protein kinase kinase kinase kinase 1 (Kinase)
Gene: MAP4K1
UniProt: Q92918 (M4K1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.03
Assay: Binding constant for HPK1 kinase domain
Drug: neratinib
Target: Serine/threonine-protein kinase PAK 6 (Kinase)
Gene: PAK6
UniProt: Q9NQU5 (PAK6_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.13
Assay: Binding constant for PAK6 kinase domain
Drug: neratinib
Target: NUAK family SNF1-like kinase 1 (Kinase)
Gene: NUAK1
UniProt: O60285 (NUAK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.82
Assay: Binding constant for ARK5 kinase domain
Drug: neratinib
Target: Mitogen-activated protein kinase kinase kinase kinase 3 (Kinase)
Gene: MAP4K3
UniProt: Q8IVH8 (M4K3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.11
Assay: Binding constant for MAP4K3 kinase domain
Drug: neratinib
Target: Tyrosine-protein kinase Blk (Kinase)
Gene: BLK
UniProt: P51451 (BLK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.07
Assay: Binding constant for BLK kinase domain
Drug: neratinib
Target: Mitogen-activated protein kinase kinase kinase kinase 4 (Kinase)
Gene: MAP4K4
UniProt: O95819 (M4K4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.48
Assay: Binding constant for MAP4K4 kinase domain
Drug: neratinib
Target: Tyrosine-protein kinase Mer (Kinase)
Gene: MERTK
UniProt: Q12866 (MERTK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.4
Assay: Binding constant for MERTK kinase domain
Drug: neratinib
Target: Mitogen-activated protein kinase kinase kinase 9 (Kinase)
Gene: MAP3K9
UniProt: P80192 (M3K9_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.27
Assay: Binding constant for MLK1 kinase domain
Drug: neratinib
Target: Mitogen-activated protein kinase kinase kinase 10 (Kinase)
Gene: MAP3K10
UniProt: Q02779 (M3K10_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.34
Assay: Binding constant for MLK2 kinase domain
Drug: neratinib
Target: Mitogen-activated protein kinase kinase kinase 11 (Kinase)
Gene: MAP3K11
UniProt: Q16584 (M3K11_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.24
Assay: Binding constant for MLK3 kinase domain
Drug: neratinib
Target: Serine/threonine-protein kinase 24 (Kinase)
Gene: STK24
UniProt: Q9Y6E0 (STK24_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.19
Assay: Binding constant for MST3 kinase domain
Drug: neratinib
Target: Serine/threonine-protein kinase PAK 1 (Kinase)
Gene: PAK1
UniProt: Q13153 (PAK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.68
Assay: Binding constant for PAK1 kinase domain
Drug: neratinib
Target: Serine/threonine-protein kinase PAK 2 (Kinase)
Gene: PAK2
UniProt: Q13177 (PAK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.1
Assay: Binding constant for PAK2 kinase domain
Drug: neratinib
Target: Serine/threonine-protein kinase SIK1 (Kinase)
Gene: SIK1
UniProt: P57059 (SIK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.66
Assay: Binding constant for SIK kinase domain
Drug: neratinib
Target: Serine/threonine-protein kinase D2 (Kinase)
Gene: PRKD2
UniProt: Q9BZL6 (KPCD2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.96
Assay: Binding constant for PRKD2 kinase domain
Drug: neratinib
Target: Serine/threonine-protein kinase D3 (Kinase)
Gene: PRKD3
UniProt: O94806 (KPCD3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.62
Assay: Binding constant for PRKD3 kinase domain
Drug: neratinib
Target: Tyrosine-protein kinase Fes/Fps (Kinase)
Gene: FES
UniProt: P07332 (FES_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.23
Assay: Binding constant for FES kinase domain
Drug: neratinib
Target: Ribosomal protein S6 kinase alpha-1 (Kinase)
Gene: RPS6KA1
UniProt: Q15418 (KS6A1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.13
Assay: Binding constant for RSK1(Kin.Dom.1-N-terminal) kinase domain
Drug: neratinib
Target: Mitogen-activated protein kinase kinase kinase kinase 2 (Kinase)
Gene: MAP4K2
UniProt: Q12851 (M4K2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.66
Assay: Binding constant for MAP4K2 kinase domain