AIM-Harvard/TrialPanorama-filtered huggingface dataset:
Drug: ruxolitinib
Target: Tyrosine-protein kinase ABL1 (Kinase)
Gene: ABL1
UniProt: P00519 (ABL1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.96
Assay: Binding constant for ABL1(H396P)-non phosphorylated kinase domain
Drug: ruxolitinib
Target: Mast/stem cell growth factor receptor Kit (Kinase)
Gene: KIT
UniProt: P10721 (KIT_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.2
Assay: Binding constant for KIT(A829P) kinase domain
Drug: ruxolitinib
Target: Serine/threonine-protein kinase B-raf (Kinase)
Gene: BRAF
UniProt: P15056 (BRAF_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.66
Assay: Binding constant for BRAF kinase domain
Drug: ruxolitinib
Target: Proto-oncogene tyrosine-protein kinase receptor Ret (Kinase)
Gene: RET
UniProt: P07949 (RET_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.72
Assay: Binding constant for RET(V804M) kinase domain
Drug: ruxolitinib
Target: Phosphorylase b kinase gamma catalytic chain, liver/testis isoform (Kinase)
Gene: PHKG2
UniProt: P15735 (PHKG2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6
Assay: Binding constant for PHKG2 kinase domain
Drug: ruxolitinib
Target: Myosin light chain kinase, smooth muscle (Kinase)
Gene: MYLK
UniProt: Q15746 (MYLK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.44
Assay: Binding constant for MYLK kinase domain
Drug: ruxolitinib
Target: Death-associated protein kinase 3 (Kinase)
Gene: DAPK3
UniProt: O43293 (DAPK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.05
Assay: Binding constant for DAPK3 kinase domain
Drug: ruxolitinib
Target: Histone deacetylase 6 (Enzyme)
Gene: HDAC6
UniProt: Q9UBN7 (HDAC6_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7.82
Assay: Inhibition of recombinant human HDAC6 using p53 (379 to 382 residues) derived fluorogenic peptide RHKKAc as substrate
Drug: ruxolitinib
Target: Calcium/calmodulin-dependent protein kinase type 1 (Kinase)
Gene: CAMK1
UniProt: Q14012 (KCC1A_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.33
Assay: Binding constant for CAMK1 kinase domain
Drug: ruxolitinib
Target: Mitogen-activated protein kinase 8 (Kinase)
Gene: MAPK8
UniProt: P45983 (MK08_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.32
Assay: Binding constant for JNK1 kinase domain
Drug: ruxolitinib
Target: Rho-associated protein kinase 1 (Kinase)
Gene: ROCK1
UniProt: Q13464 (ROCK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.22
Assay: Binding constant for ROCK1 kinase domain
Drug: ruxolitinib
Target: Tyrosine-protein kinase JAK1 (Kinase)
Gene: JAK1
UniProt: P23458 (JAK1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 10.05
Action type: INHIBITOR
Assay: Inhibition of purified JAK1 incubated for 30 mins
Drug: ruxolitinib
Target: Serine/threonine-protein kinase PLK1 (Kinase)
Gene: PLK1
UniProt: P53350 (PLK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.89
Assay: Binding constant for PLK1 kinase domain
Drug: ruxolitinib
Target: Death-associated protein kinase 2 (Kinase)
Gene: DAPK2
UniProt: Q9UIK4 (DAPK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.01
Assay: Binding constant for DAPK2 kinase domain
Drug: ruxolitinib
Target: High affinity nerve growth factor receptor (Kinase)
Gene: NTRK1
UniProt: P04629 (NTRK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.82
Assay: Binding constant for TRKA kinase domain
Drug: ruxolitinib
Target: Tyrosine-protein kinase JAK2 (Kinase)
Gene: JAK2
UniProt: O60674 (JAK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 10.44
Action type: INHIBITOR
Assay: Binding constant for JAK2(JH1domain-catalytic) kinase domain
Drug: ruxolitinib
Target: Rho-associated protein kinase 2 (Kinase)
Gene: ROCK2
UniProt: O75116 (ROCK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.28
Assay: Binding constant for ROCK2 kinase domain
Drug: ruxolitinib
Target: Calcium/calmodulin-dependent protein kinase type II subunit delta (Kinase)
Gene: CAMK2D
UniProt: Q13557 (KCC2D_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.05
Assay: Binding constant for CAMK2D kinase domain
Drug: ruxolitinib
Target: Calcium/calmodulin-dependent protein kinase type II subunit gamma (Kinase)
Gene: CAMK2G
UniProt: Q13555 (KCC2G_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7
Assay: Binding constant for CAMK2G kinase domain
Drug: ruxolitinib
Target: AP2-associated protein kinase 1 (Kinase)
Gene: AAK1
UniProt: Q2M2I8 (AAK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.92
Assay: Binding constant for AAK1 kinase domain
Drug: ruxolitinib
Target: Serine/threonine-protein kinase MARK2 (Kinase)
Gene: MARK2
UniProt: Q7KZI7 (MARK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.18
Assay: Binding constant for MARK2 kinase domain
Drug: ruxolitinib
Target: Ribosomal protein S6 kinase alpha-2 (Kinase)
Gene: RPS6KA2
UniProt: Q15349 (KS6A2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.82
Assay: Binding constant for RSK3(Kin.Dom.2-C-terminal) kinase domain
Drug: ruxolitinib
Target: Calcium/calmodulin-dependent protein kinase type II subunit beta (Kinase)
Gene: CAMK2B
UniProt: Q13554 (KCC2B_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.51
Assay: Binding constant for CAMK2B kinase domain
Drug: ruxolitinib
Target: Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform (Kinase)
Gene: PHKG1
UniProt: Q16816 (PHKG1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.24
Assay: Binding constant for PHKG1 kinase domain
Drug: ruxolitinib
Target: Calcium/calmodulin-dependent protein kinase type II subunit alpha (Kinase)
Gene: CAMK2A
UniProt: Q9UQM7 (KCC2A_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.34
Assay: Binding constant for CAMK2A kinase domain
Drug: ruxolitinib
Target: Serine/threonine-protein kinase 17B (Kinase)
Gene: STK17B
UniProt: O94768 (ST17B_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.46
Assay: Binding constant for DRAK2 kinase domain
Drug: ruxolitinib
Target: Protein kinase C epsilon type (Kinase)
Gene: PRKCE
UniProt: Q02156 (KPCE_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.28
Assay: Binding constant for PRKCE kinase domain
Drug: ruxolitinib
Target: Serine/threonine-protein kinase PLK4 (Kinase)
Gene: PLK4
UniProt: O00444 (PLK4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.7
Assay: Binding constant for PLK4 kinase domain
Drug: ruxolitinib
Target: Aurora kinase C (Kinase)
Gene: AURKC
UniProt: Q9UQB9 (AURKC_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.06
Assay: Binding constant for AURKC kinase domain
Drug: ruxolitinib
Target: Serine/threonine-protein kinase 16 (Kinase)
Gene: STK16
UniProt: O75716 (STK16_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.31
Assay: Binding constant for STK16 kinase domain
Drug: ruxolitinib
Target: Dual specificity protein kinase TTK (Kinase)
Gene: TTK
UniProt: P33981 (TTK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.32
Assay: Binding constant for TTK kinase domain
Drug: ruxolitinib
Target: Serine/threonine-protein kinase 17A (Kinase)
Gene: STK17A
UniProt: Q9UEE5 (ST17A_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.21
Assay: Binding constant for DRAK1 kinase domain
Drug: ruxolitinib
Target: ALK tyrosine kinase receptor (Kinase)
Gene: ALK
UniProt: Q9UM73 (ALK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.82
Assay: Binding constant for ALK kinase domain
Drug: ruxolitinib
Target: Ephrin type-A receptor 3 (Kinase)
Gene: EPHA3
UniProt: P29320 (EPHA3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.21
Assay: Binding constant for EPHA3 kinase domain
Drug: ruxolitinib
Target: BMP-2-inducible protein kinase (Kinase)
Gene: BMP2K
UniProt: Q9NSY1 (BMP2K_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.68
Assay: Binding constant for BIKE kinase domain
Drug: ruxolitinib
Target: Dual specificity protein kinase CLK2 (Kinase)
Gene: CLK2
UniProt: P49760 (CLK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.34
Assay: Binding constant for CLK2 kinase domain
Drug: ruxolitinib
Target: Cyclin-G-associated kinase (Kinase)
Gene: GAK
UniProt: O14976 (GAK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7
Assay: Binding constant for GAK kinase domain
Drug: ruxolitinib
Target: Calcium/calmodulin-dependent protein kinase type 1D (Kinase)
Gene: CAMK1D
UniProt: Q8IU85 (KCC1D_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.92
Assay: Binding constant for CAMK1D kinase domain
Drug: ruxolitinib
Target: Activated CDC42 kinase 1 (Kinase)
Gene: TNK2
UniProt: Q07912 (ACK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.59
Assay: Binding constant for TNK2 kinase domain
Drug: ruxolitinib
Target: Ribosomal protein S6 kinase alpha-5 (Kinase)
Gene: RPS6KA5
UniProt: O75582 (KS6A5_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.85
Assay: Binding constant for RPS6KA5(Kin.Dom.2-C-terminal) kinase domain
Drug: ruxolitinib
Target: Dual specificity protein kinase CLK4 (Kinase)
Gene: CLK4
UniProt: Q9HAZ1 (CLK4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.77
Assay: Binding constant for CLK4 kinase domain
Drug: ruxolitinib
Target: MAP kinase-interacting serine/threonine-protein kinase 2 (Kinase)
Gene: MKNK2
UniProt: Q9HBH9 (MKNK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.7
Assay: Binding constant for MKNK2 kinase domain
Drug: ruxolitinib
Target: Calcium/calmodulin-dependent protein kinase type 1G (Kinase)
Gene: CAMK1G
UniProt: Q96NX5 (KCC1G_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.66
Assay: Binding constant for CAMK1G kinase domain
Drug: ruxolitinib
Target: Inhibitor of nuclear factor kappa-B kinase subunit beta (Kinase)
Gene: IKBKB
UniProt: O14920 (IKKB_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.64
Assay: Binding constant for IKK-beta kinase domain
Drug: ruxolitinib
Target: Dual specificity mitogen-activated protein kinase kinase 1 (Kinase)
Gene: MAP2K1
UniProt: Q02750 (MP2K1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.72
Assay: Binding constant for MEK1 kinase domain
Drug: ruxolitinib
Target: Dual specificity mitogen-activated protein kinase kinase 2 (Kinase)
Gene: MAP2K2
UniProt: P36507 (MP2K2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.4
Assay: Binding constant for MEK2 kinase domain
Drug: ruxolitinib
Target: BDNF/NT-3 growth factors receptor (Kinase)
Gene: NTRK2
UniProt: Q16620 (NTRK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.44
Assay: Binding constant for TRKB kinase domain
Drug: ruxolitinib
Target: Cyclin-dependent kinase 7 (Kinase)
Gene: CDK7
UniProt: P50613 (CDK7_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.48
Assay: Binding constant for CDK7 kinase domain
Drug: ruxolitinib
Target: Serine/threonine-protein kinase DCLK3 (Kinase)
Gene: DCLK3
UniProt: Q9C098 (DCLK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.59
Assay: Binding constant for DCAMKL3 kinase domain
Drug: ruxolitinib
Target: Ribosomal protein S6 kinase alpha-6 (Kinase)
Gene: RPS6KA6
UniProt: Q9UK32 (KS6A6_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.82
Assay: Binding constant for RSK4(Kin.Dom.2-C-terminal) kinase domain
Drug: ruxolitinib
Target: NUAK family SNF1-like kinase 2 (Kinase)
Gene: NUAK2
UniProt: Q9H093 (NUAK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.49
Assay: Binding constant for SNARK kinase domain
Drug: ruxolitinib
Target: Non-receptor tyrosine-protein kinase TYK2 (Kinase)
Gene: TYK2
UniProt: P29597 (TYK2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 9.3
Assay: Inhibition of TYK2 kinase domain using N-terminal 5-carboxyfluorescein-tagged Val-Ala-Leu-Val-Asp-Gly-Tyr-Phe-Arg-Leu-Thr-Thr as substrate after 30 mins
Drug: ruxolitinib
Target: Serine/threonine-protein kinase 25 (Kinase)
Gene: STK25
UniProt: O00506 (STK25_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.2
Assay: Binding constant for YSK1 kinase domain
Drug: ruxolitinib
Target: Serine/threonine-protein kinase RIO1 (Kinase)
Gene: RIOK1
UniProt: Q9BRS2 (RIOK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.6
Assay: Binding constant for RIOK1 kinase domain
Drug: ruxolitinib
Target: NT-3 growth factor receptor (Kinase)
Gene: NTRK3
UniProt: Q16288 (NTRK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.48
Assay: Binding constant for TRKC kinase domain
Drug: ruxolitinib
Target: Casein kinase II subunit alpha (Kinase)
Gene: CSNK2A1
UniProt: P68400 (CSK21_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.38
Assay: Binding constant for CSNK2A1 kinase domain
Drug: ruxolitinib
Target: Casein kinase II subunit alpha' (Kinase)
Gene: CSNK2A2
UniProt: P19784 (CSK22_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.48
Assay: Binding constant for CSNK2A2 kinase domain
Drug: ruxolitinib
Target: Inhibitor of nuclear factor kappa-B kinase subunit epsilon (Kinase)
Gene: IKBKE
UniProt: Q14164 (IKKE_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.92
Assay: Binding constant for IKK-epsilon kinase domain
Drug: ruxolitinib
Target: Dual specificity mitogen-activated protein kinase kinase 3 (Kinase)
Gene: MAP2K3
UniProt: P46734 (MP2K3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.33
Assay: Binding constant for MEK3 kinase domain
Drug: ruxolitinib
Target: Maternal embryonic leucine zipper kinase (Kinase)
Gene: MELK
UniProt: Q14680 (MELK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.66
Assay: Binding constant for MELK kinase domain
Drug: ruxolitinib
Target: Serine/threonine-protein kinase 26 (Kinase)
Gene: STK26
UniProt: Q9P289 (STK26_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.51
Assay: Binding constant for MST4 kinase domain
Drug: ruxolitinib
Target: Serine/threonine-protein kinase Nek7 (Kinase)
Gene: NEK7
UniProt: Q8TDX7 (NEK7_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.31
Assay: Binding constant for NEK7 kinase domain
Drug: ruxolitinib
Target: Serine/threonine-protein kinase RIO3 (Kinase)
Gene: RIOK3
UniProt: O14730 (RIOK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.7
Assay: Binding constant for RIOK3 kinase domain
Drug: ruxolitinib
Target: SRSF protein kinase 1 (Kinase)
Gene: SRPK1
UniProt: Q96SB4 (SRPK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.68
Assay: Binding constant for SRPK1 kinase domain
Drug: ruxolitinib
Target: Ankyrin repeat and protein kinase domain-containing protein 1 (Kinase)
Gene: ANKK1
UniProt: Q8NFD2 (ANKK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.41
Assay: Binding constant for ANKK1 kinase domain
Drug: ruxolitinib
Target: Myotonin-protein kinase (Kinase)
Gene: DMPK
UniProt: Q09013 (DMPK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.46
Assay: Binding constant for DMPK kinase domain
Drug: ruxolitinib
Target: Leukocyte tyrosine kinase receptor (Kinase)
Gene: LTK
UniProt: P29376 (LTK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.36
Assay: Binding constant for LTK kinase domain
Drug: ruxolitinib
Target: Serine/threonine-protein kinase PAK 6 (Kinase)
Gene: PAK6
UniProt: Q9NQU5 (PAK6_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.54
Assay: Binding constant for PAK6 kinase domain
Drug: ruxolitinib
Target: Serine/threonine-protein kinase PAK 7 (Kinase)
Gene: PAK5
UniProt: Q9P286 (PAK5_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.89
Assay: Binding constant for PAK7 kinase domain
Drug: ruxolitinib
Target: Bone morphogenetic protein receptor type-2 (Kinase)
Gene: BMPR2
UniProt: Q13873 (BMPR2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.03
Assay: Binding constant for BMPR2 kinase domain
Drug: ruxolitinib
Target: Dual specificity mitogen-activated protein kinase kinase 4 (Kinase)
Gene: MAP2K4
UniProt: P45985 (MP2K4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.74
Assay: Binding constant for MEK4 kinase domain
Drug: ruxolitinib
Target: Death-associated protein kinase 1 (Kinase)
Gene: DAPK1
UniProt: P53355 (DAPK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.14
Assay: Binding constant for DAPK1 kinase domain
Drug: ruxolitinib
Target: Serine/threonine-protein kinase DCLK1 (Kinase)
Gene: DCLK1
UniProt: O15075 (DCLK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.17
Assay: Binding constant for DCAMKL1 kinase domain
Drug: ruxolitinib
Target: Serine/threonine-protein kinase DCLK2 (Kinase)
Gene: DCLK2
UniProt: Q8N568 (DCLK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.12
Assay: Binding constant for DCAMKL2 kinase domain
Drug: ruxolitinib
Target: Serine/threonine-protein kinase PAK 4 (Kinase)
Gene: PAK4
UniProt: O96013 (PAK4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.8
Assay: Binding constant for PAK4 kinase domain
Drug: ruxolitinib
Target: Serine/threonine-protein kinase PLK3 (Kinase)
Gene: PLK3
UniProt: Q9H4B4 (PLK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.15
Assay: Binding constant for PLK3 kinase domain
Drug: ruxolitinib
Target: cGMP-dependent protein kinase 2 (Kinase)
Gene: PRKG2
UniProt: Q13237 (KGP2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.16
Assay: Binding constant for PRKG2 kinase domain
Drug: ruxolitinib
Target: Ribosomal protein S6 kinase alpha-1 (Kinase)
Gene: RPS6KA1
UniProt: Q15418 (KS6A1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.92
Assay: Binding constant for RSK1(Kin.Dom.2-C-terminal) kinase domain
Drug: ruxolitinib
Target: Ribosomal protein S6 kinase alpha-4 (Kinase)
Gene: RPS6KA4
UniProt: O75676 (KS6A4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.47
Assay: Binding constant for RPS6KA4(Kin.Dom.2-C-terminal) kinase domain
Drug: ruxolitinib
Target: Casein kinase I isoform alpha (Kinase)
Gene: CSNK1A1
UniProt: P48729 (KC1A_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.74
Assay: Binding constant for CSNK1A1 kinase domain
Drug: ruxolitinib
Target: Mitogen-activated protein kinase kinase kinase kinase 2 (Kinase)
Gene: MAP4K2
UniProt: Q12851 (M4K2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.7
Assay: Binding constant for MAP4K2 kinase domain
Drug: ruxolitinib
Target: Serine/threonine-protein kinase TBK1 (Kinase)
Gene: TBK1
UniProt: Q9UHD2 (TBK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.77
Assay: Binding constant for TBK1 kinase domain
Drug: ruxolitinib
Target: Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Kinase)
Gene: DYRK1A
UniProt: Q13627 (DYR1A_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.04
Assay: Binding constant for DYRK1A kinase domain
Drug: ruxolitinib
Target: Dual specificity tyrosine-phosphorylation-regulated kinase 2 (Kinase)
Gene: DYRK2
UniProt: Q92630 (DYRK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.43
Assay: Binding constant for DYRK2 kinase domain
Drug: ruxolitinib
Target: Ephrin type-B receptor 6 (Kinase)
Gene: EPHB6
UniProt: O15197 (EPHB6_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.51
Assay: Binding constant for EPHB6 kinase domain
Drug: ruxolitinib
Target: Serine/threonine-protein kinase/endoribonuclease IRE1 (Kinase)
Gene: ERN1
UniProt: O75460 (ERN1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.6
Assay: Binding constant for ERN1 kinase domain
Drug: ruxolitinib
Target: Rhodopsin kinase (Kinase)
Gene: GRK1
UniProt: Q15835 (RK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.14
Assay: Binding constant for GRK1 kinase domain
Drug: ruxolitinib
Target: G protein-coupled receptor kinase 4 (Kinase)
Gene: GRK4
UniProt: P32298 (GRK4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.21
Assay: Binding constant for GRK4 kinase domain
Drug: ruxolitinib
Target: G protein-coupled receptor kinase 7 (Kinase)
Gene: GRK7
UniProt: Q8WTQ7 (GRK7_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.27
Assay: Binding constant for GRK7 kinase domain
Drug: ruxolitinib
Target: Homeodomain-interacting protein kinase 2 (Kinase)
Gene: HIPK2
UniProt: Q9H2X6 (HIPK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6
Assay: Binding constant for HIPK2 kinase domain
Drug: ruxolitinib
Target: Homeodomain-interacting protein kinase 3 (Kinase)
Gene: HIPK3
UniProt: Q9H422 (HIPK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.92
Assay: Binding constant for HIPK3 kinase domain
Drug: ruxolitinib
Target: Interleukin-1 receptor-associated kinase 1 (Kinase)
Gene: IRAK1
UniProt: P51617 (IRAK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.54
Assay: Binding constant for IRAK1 kinase domain
Drug: ruxolitinib
Target: Mitogen-activated protein kinase kinase kinase 2 (Kinase)
Gene: MAP3K2
UniProt: Q9Y2U5 (M3K2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.39
Assay: Binding constant for MAP3K2 kinase domain
Drug: ruxolitinib
Target: Mitogen-activated protein kinase kinase kinase 3 (Kinase)
Gene: MAP3K3
UniProt: Q99759 (M3K3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.82
Assay: Binding constant for MAP3K3 kinase domain
Drug: ruxolitinib
Target: Microtubule-associated serine/threonine-protein kinase 1 (Kinase)
Gene: MAST1
UniProt: Q9Y2H9 (MAST1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.28
Assay: Binding constant for MAST1 kinase domain
Drug: ruxolitinib
Target: Serine/threonine-protein kinase OSR1 (Kinase)
Gene: OXSR1
UniProt: O95747 (OXSR1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.57
Assay: Binding constant for OSR1 kinase domain
Drug: ruxolitinib
Target: Serine/threonine-protein kinase RIO2 (Kinase)
Gene: RIOK2
UniProt: Q9BVS4 (RIOK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.92
Assay: Binding constant for RIOK2 kinase domain
Drug: ruxolitinib
Target: SRSF protein kinase 3 (Kinase)
Gene: SRPK3
UniProt: Q9UPE1 (SRPK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.48
Assay: Binding constant for SRPK3 kinase domain
Drug: ruxolitinib
Target: STE20/SPS1-related proline-alanine-rich protein kinase (Kinase)
Gene: STK39
UniProt: Q9UEW8 (STK39_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.72
Assay: Binding constant for STK39 kinase domain
Drug: ruxolitinib
Target: Mitogen-activated protein kinase kinase kinase 7 (Kinase)
Gene: MAP3K7
UniProt: O43318 (M3K7_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.14
Assay: Binding constant for TAK1 kinase domain
Drug: ruxolitinib
Target: Serine/threonine-protein kinase TAO1 (Kinase)
Gene: TAOK1
UniProt: Q7L7X3 (TAOK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.89
Assay: Binding constant for TAOK1 kinase domain
Drug: ruxolitinib
Target: Serine/threonine-protein kinase TAO3 (Kinase)
Gene: TAOK3
UniProt: Q9H2K8 (TAOK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.23
Assay: Binding constant for TAOK3 kinase domain
Drug: ruxolitinib
Target: Serine/threonine-protein kinase ULK1 (Kinase)
Gene: ULK1
UniProt: O75385 (ULK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.52
Assay: Binding constant for ULK1 kinase domain
Drug: ruxolitinib
Target: Serine/threonine-protein kinase ULK2 (Kinase)
Gene: ULK2
UniProt: Q8IYT8 (ULK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.72
Assay: Binding constant for ULK2 kinase domain
Drug: ruxolitinib
Target: Serine/threonine-protein kinase ULK3 (Kinase)
Gene: ULK3
UniProt: Q6PHR2 (ULK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.62
Assay: Binding constant for ULK3 kinase domain
Drug: ruxolitinib
Target: Mitogen-activated protein kinase kinase kinase 19 (Kinase)
Gene: MAP3K19
UniProt: Q56UN5 (M3K19_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.57
Assay: Binding constant for YSK4 kinase domain
Drug: ruxolitinib
Target: Homeodomain-interacting protein kinase 1 (Kinase)
Gene: HIPK1
UniProt: Q86Z02 (HIPK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.92
Assay: Binding constant for HIPK1 kinase domain
Drug: ruxolitinib
Target: Mitogen-activated protein kinase kinase kinase 15 (Kinase)
Gene: MAP3K15
UniProt: Q6ZN16 (M3K15_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.96
Assay: Binding constant for MAP3K15 kinase domain
Drug: ruxolitinib
Target: Serine/threonine-protein kinase PLK2 (Kinase)
Gene: PLK2
UniProt: Q9NYY3 (PLK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.82
Assay: Binding constant for PLK2 kinase domain
Drug: ruxolitinib
Target: Receptor-interacting serine/threonine-protein kinase 4 (Kinase)
Gene: RIPK4
UniProt: P57078 (RIPK4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.68
Assay: Binding constant for RIPK4 kinase domain
Drug: ruxolitinib
Target: Uncharacterized serine/threonine-protein kinase SBK3 (Kinase)
Gene: SBK3
UniProt: P0C264 (SBK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.24
Assay: Binding constant for SgK110 kinase domain
Drug: ruxolitinib
Target: Mitogen-activated protein kinase kinase kinase 1 (Kinase)
Gene: MAP3K1
UniProt: Q13233 (M3K1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.38
Assay: Binding constant for MAP3K1 kinase domain
Drug: ruxolitinib
Target: Phosphatidylinositol 4-kinase beta (Kinase)
Gene: PI4KB
UniProt: Q9UBF8 (PI4KB_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.47
Assay: Binding constant for PIK4CB kinase domain
Drug: ruxolitinib
Target: Serine/threonine-protein kinase SIK3 (Kinase)
Gene: SIK3
UniProt: Q9Y2K2 (SIK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.89
Assay: Binding constant for QSK kinase domain
Drug: ruxolitinib
Target: Bone morphogenetic protein receptor type-1B (Kinase)
Gene: BMPR1B
UniProt: O00238 (BMR1B_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.74
Assay: Binding constant for BMPR1B kinase domain