AIM-Harvard/TrialPanorama-filtered huggingface dataset:
Drug: amantadine
Target: Matrix protein 2 (Unclassified)
Gene: M
UniProt: P0DOF8 (M2_I72A8)
Organism: Influenza A virus
Activity: EC50 = 6.18
Assay: Inhibition of wild type Influenza A virus (A/chicken/Hubei/327/2004(H5N1)) M2 expressed in yeast cells after 46 to 48 hrs
Drug: ambenonium
Target: Acetylcholinesterase (Enzyme)
Gene: ACHE
UniProt: P22303 (ACES_HUMAN)
Organism: Homo sapiens
Action type: INHIBITOR
Assay: Mechanism of Action; CHEMBL220; SINGLE PROTEIN
Drug: ambenonium
Target: Acetylcholinesterase (Enzyme)
Gene: Ache
UniProt: P21836 (ACES_MOUSE)
Organism: Mus musculus
Activity: Kd = 4.34
Assay: Binding affinity to mouse AChE by equilibrium binding assay
Drug: ambenonium
Target: Acetylcholinesterase (Enzyme)
Gene: ACHE
UniProt: P23795 (ACES_BOVIN)
Organism: Bos taurus
Activity: IC50 = 9.92
Assay: Inhibition of bovine AChE by Ellman's method
Drug: ambroxol
Target: Sodium-dependent serotonin transporter (Transporter)
Gene: SLC6A4
UniProt: P31645 (SC6A4_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.744
Assay: DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine)
Drug: ambroxol
Target: Cytochrome P450 2D6 (Enzyme)
Gene: CYP2D6
UniProt: P10635 (CP2D6_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.254
Assay: DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)
Drug: ambroxol
Target: Sodium channel protein type 10 subunit alpha (Ion channel)
Gene: SCN10A
UniProt: Q9Y5Y9 (SCNAA_HUMAN)
Organism: Homo sapiens
Drug: ambroxol
Target: Glucosylceramidase (Enzyme)
Gene: GBA
UniProt: P04062 (GLCM_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.39
Assay: Inhibition of beta-glucocerebrosidase in human fibroblast lysate using 4-methylumbelliferyl beta-D-glycopyranoside as substrate by fluorimetric analysis
Drug: amcinonide
Target: Glucocorticoid receptor (Nuclear hormone receptor)
Gene: NR3C1
UniProt: P04150 (GCR_HUMAN)
Organism: Homo sapiens
Action type: AGONIST
Assay: Mechanism of Action; CHEMBL2034; SINGLE PROTEIN
Drug: amidefrine
Target: Adrenergic receptor alpha-2 (GPCR)
Gene: Adra2b|Adra2c|Adra2a
UniProt: P19328|P22086|P22909 (ADA2B_RAT|ADA2C_RAT|ADA2A_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 4.72
Assay: 50% inhibition of specific [3H]clonidine binding (0.4 nM) to Alpha-2 adrenergic receptors in rat isolated brain membranes
Drug: amidefrine
Target: Adrenergic receptor alpha-1 (GPCR)
Gene: Adra1b|Adra1d|Adra1a
UniProt: P15823|P23944|P43140 (ADA1B_RAT|ADA1D_RAT|ADA1A_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 4.4
Assay: Binding affinity against alpha-1 adrenergic receptor is the ability to inhibit the specific [3H]prazosin binding (0.4 nM) to rat isolated brain membranes by 50% was reported.
Drug: amifostine
Target: D(3) dopamine receptor (GPCR)
Gene: DRD3
UniProt: P35462 (DRD3_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.184
Assay: DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone)
Drug: amifostine
Target: Alkaline phosphatase, tissue-nonspecific isozyme (Enzyme)
Gene: ALPL
UniProt: P05186 (PPBT_HUMAN)
Organism: Homo sapiens
Drug: amikacin
Target: Macrolide 2'-phosphotransferase II; Macrolide 2'-phosphotransferase II protein MphB; Macrolide 2-phosphotransferase, mph(B) (Enzyme)
Gene: mphB
UniProt: O32553 (O32553_ECOLX)
Organism: Escherichia coli
Activity: Km = 4.201
Drug: amiloride
Target: Amiloride-sensitive sodium channel subunit alpha (Ion channel)
Gene: SCNN1A
UniProt: P37088 (SCNNA_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.11
Assay: Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay
Drug: amiloride
Target: Urokinase-type plasminogen activator (Enzyme)
Gene: PLAU
UniProt: P00749 (UROK_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.16
Drug: amiloride
Target: Adenosine receptor A2a (GPCR)
Gene: ADORA2A
UniProt: P29274 (AA2AR_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.48
Drug: amiloride
Target: Amine oxidase [flavin-containing] A (Enzyme)
Gene: MAOA
UniProt: P21397 (AOFA_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.408
Assay: DRUGMATRIX: Monoamine Oxidase MAO-A enzyme inhibition (substrate: Kynuramine)
Drug: amiloride
Target: Sodium/hydrogen exchanger 1 (Transporter)
Gene: SLC9A1
UniProt: P19634 (SL9A1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.22
Assay: Inhibition of human wild type NHE1 expressed in chinese hamster AP1 cells assessed as intracellular pHi recovery by ammonium chloride prepulse protocol
Drug: amiloride
Target: Solute carrier family 22 member 1 (Transporter)
Gene: SLC22A1
UniProt: O15245 (S22A1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.24
Assay: Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells by confocal microscopy
Drug: amiloride
Target: Acid-sensing ion channel 2 (Ion channel)
Gene: ASIC2
UniProt: Q16515 (ASIC2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.6
Action type: BLOCKER
Drug: amiloride
Target: Acid-sensing ion channel 1 (Ion channel)
Gene: ASIC1
UniProt: P78348 (ASIC1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5
Assay: GRAC: human ASIC1 blocker
Drug: amiloride
Target: Membrane primary amine oxidase (Enzyme)
Gene: Aoc3
UniProt: O08590 (AOC3_RAT)
Organism: Rattus norvegicus
Activity: Ki = 5
Assay: Inhibitory activity against porcine kidney amine oxidase
Drug: amiloride
Target: Acid-sensing ion channel 3 (Ion channel)
Gene: ASIC3
UniProt: Q9UHC3 (ASIC3_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.36
Assay: Inhibition of ASIC3 assessed as inhibition of peak current by patch clamp electrophysiology
Drug: amiloride
Target: Amiloride-sensitive sodium channel, ENaC (Ion channel)
Gene: SCNN1A|SCNN1B|SCNN1G
UniProt: P37088|P51168|P51170 (SCNNA_HUMAN|SCNNB_HUMAN|SCNNG_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.7
Action type: BLOCKER
Assay: GRAC: human ENaC blocker
Drug: amiloride
Target: Sodium/hydrogen exchanger (Transporter)
Gene: NHE1
UniProt: Q9W6Q1 (Q9W6Q1_9SALA)
Organism: Amphiuma tridactylum
Activity: IC50 = 4.01
Assay: Inhibition of Amphiuma tridactylum wild type NHE1 expressed in chinese hamster AP1 cells assessed as intracellular pHi recovery by ammonium chloride prepulse protocol
Drug: amiloride
Target: Sodium/hydrogen exchanger 5 (Transporter)
Gene: SLC9A5
UniProt: Q14940 (SL9A5_HUMAN)
Organism: Homo sapiens
Activity: Ki = 4.68
Action type: INHIBITOR
Drug: amiloride
Target: Sodium/hydrogen exchanger 1 (Transporter)
Gene: Slc9a1
UniProt: P26431 (SL9A1_RAT)
Organism: Rattus norvegicus
Activity: Ki = 6
Action type: INHIBITOR
Drug: amiloride
Target: Sodium/hydrogen exchanger 2 (Transporter)
Gene: SLC9A2
UniProt: P50482 (SL9A2_RABIT)
Organism: Oryctolagus cuniculus
Activity: Ki = 6
Assay: Inhibition of rabbit NHE2
Drug: amiloride
Target: Urokinase-type plasminogen activator (Enzyme)
Gene: Plau
UniProt: P06869 (UROK_MOUSE)
Organism: Mus musculus
Activity: Ki = 5.64
Assay: Inhibition of mouse uPA using Z-Gly-Gly-Arg-AMC as substrate after 15 mins by fluorescence assay
Drug: amiloride
Target: Acid-sensing ion channel 1 (Ion channel)
Gene: Asic1
UniProt: P55926 (ASIC1_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 4.52
Assay: Inhibition of ASIC1 in Sprague-Dawley rat articular chondrocytes assessed as decrease in acid-induced intracellular calcium level by Fluo-3AM dye based laser scanning confocal microscopy
Drug: aminoacridine
Target: Ribosyldihydronicotinamide dehydrogenase [quinone] (Enzyme)
Gene: NQO2
UniProt: P16083 (NQO2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.36
Assay: Inhibition of recombinant human NQO2 expressed in Escherichia coli using DCPIP as substrate by spectrophotometry
Drug: aminoacridine
Target: Trypanothione reductase (Enzyme)
Gene: TPR
UniProt: P28593 (TYTR_TRYCR)
Organism: Trypanosoma cruzi
Activity: Ki = 4.42
Assay: The competitive inhibitory activity against trypanothione reductase was evaluated from Lineweaver Burk plots
Drug: amineptine
Target: Sodium-dependent dopamine transporter (Transporter)
Gene: Slc6a3
UniProt: P23977 (SC6A3_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 6
Assay: Inhibition of dopamine transporter-mediated [3H]dopamine uptake in Wistar rat striatal synaptosomes by liquid scintillation spectrometry
Drug: aminocaproic acid
Target: Plasminogen (Enzyme)
Gene: PLG
UniProt: P00747 (PLMN_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.4
Action type: INHIBITOR
Assay: Binding affinity to full length Glu-plasminogen in human plasma assessed as inhibition of interaction with fibrin in presence of tPA
Drug: aminocaproic acid
Target: Tissue-type plasminogen activator (Enzyme)
Gene: PLAT
UniProt: P00750 (TPA_HUMAN)
Organism: Homo sapiens
Action type: INHIBITOR
Drug: aminoglutethimide
Target: Aromatase (Enzyme)
Gene: CYP19A1
UniProt: P11511 (CP19A_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.11
Action type: INHIBITOR
Drug: aminoglutethimide
Target: Thromboxane-A synthase (Enzyme)
Gene: TBXAS1
UniProt: P24557 (THAS_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.73
Assay: Inhibition of Thromboxane-A synthase
Drug: aminoglutethimide
Target: Cholesterol side-chain cleavage enzyme, mitochondrial (Enzyme)
Gene: CYP11A1
UniProt: P05108 (CP11A_HUMAN)
Organism: Homo sapiens
Action type: INHIBITOR
Assay: Mechanism of Action; CHEMBL2033; SINGLE PROTEIN
Drug: aminoglutethimide
Target: Aromatase (Enzyme)
Gene: Cyp19a1
UniProt: P22443 (CP19A_RAT)
Organism: Rattus norvegicus
Activity: EC50 = 6.59
Assay: In vitro inhibition of cytochrome P450 19A1 by rat ovarian microsomes incubated with [3H]androstenedione and NADPH-generating system.
Drug: aminoglutethimide
Target: Cytochrome P450 11A1 (Enzyme)
Gene: CYP11A1
UniProt: P00189 (CP11A_BOVIN)
Organism: Bos taurus
Activity: IC50 = 4.54
Assay: Inhibition of bovine adrenal desmolase
Drug: aminohippuric acid
Target: Solute carrier family 22 member 6 (Transporter)
Gene: SLC22A6
UniProt: Q4U2R8 (S22A6_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.22
Assay: Inhibition of human Oat1 expressed in Drosophila S2 cells
Drug: aminohippuric acid
Target: Solute carrier family 22 member 6 (Transporter)
Gene: Slc22a6
UniProt: Q8VC69 (S22A6_MOUSE)
Organism: Mus musculus
Activity: Ki = 5.03
Assay: Inhibition of mouse Oat1-mediated [3H]PAH uptake in Xenopus oocytes after 1 hr
Drug: aminophenazone
Target: Prostaglandin G/H synthase 2 (Enzyme)
Gene: PTGS2
UniProt: P35354 (PGH2_HUMAN)
Organism: Homo sapiens
Drug: aminophenazone
Target: Prostaglandin G/H synthase 1 (Enzyme)
Gene: PTGS1
UniProt: P23219 (PGH1_HUMAN)
Organism: Homo sapiens
Drug: aminophenazone
Target: Nicotinate phosphoribosyltransferase (Enzyme)
Gene: NAPRT
UniProt: Q6XQN6 (PNCB_HUMAN)
Organism: Homo sapiens
Activity: Ki = 9
Assay: Inhibition of NAPRT (unknown origin)
Drug: aminopicoline
Target: Nitric oxide synthase, inducible (Enzyme)
Gene: NOS2
UniProt: P35228 (NOS2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7.4
Action type: INHIBITOR
Drug: aminoquinuride
Target: Matrix metalloproteinase-9 (Enzyme)
Gene: MMP9
UniProt: P14780 (MMP9_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4
Assay: Inhibition of human MMP-9 after 60 mins by FRET assay
Drug: aminoquinuride
Target: Interstitial collagenase (Enzyme)
Gene: MMP1
UniProt: P03956 (MMP1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.51
Assay: Inhibition of human MMP-1 after 60 mins by FRET assay
Drug: aminoquinuride
Target: Lethal factor (Enzyme)
Gene: lef
UniProt: P15917 (LEF_BACAN)
Organism: Bacillus anthracis
Activity: Ki = 6.3
Assay: Competitive inhibition of Bacillus anthracis lethal factor
Drug: aminoquinuride
Target: Botulinum neurotoxin type A (Enzyme)
Gene: botA
UniProt: P10845 (BXA1_CLOBO)
Organism: Clostridium botulinum
Activity: IC50 = 5.14
Assay: Inhibition of Clostridium bolulinum BoNT/A assessed as cleavage of MOCAc-Lys-Lys-Val-Tyr-Pro-Tyr-Pro-Met-Glu-Lys(Dnp)-NH2 after 40 mins by FRET assay
Drug: amiodarone
Target: Beta-1 adrenergic receptor (GPCR)
Gene: ADRB1
UniProt: P08588 (ADRB1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.7
Drug: amiodarone
Target: Sodium channel protein type 5 subunit alpha (Ion channel)
Gene: SCN5A
UniProt: Q14524 (SCN5A_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7.1
Action type: BLOCKER
Drug: amiodarone
Target: Mu-type opioid receptor (GPCR)
Gene: OPRM1
UniProt: P35372 (OPRM_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.112
Assay: DRUGMATRIX: Opiate mu (OP3, MOP) radioligand binding (ligand: [3H] Diprenorphine)
Drug: amiodarone
Target: D(1A) dopamine receptor (GPCR)
Gene: DRD1
UniProt: P21728 (DRD1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.34
Assay: DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)
Drug: amiodarone
Target: D(2) dopamine receptor (GPCR)
Gene: DRD2
UniProt: P14416 (DRD2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.177
Assay: DRUGMATRIX: Dopamine D2L radioligand binding (ligand: [3H] Spiperone)
Drug: amiodarone
Target: Alpha-2A adrenergic receptor (GPCR)
Gene: ADRA2A
UniProt: P08913 (ADA2A_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.3
Drug: amiodarone
Target: Sigma non-opioid intracellular receptor 1 (Membrane receptor)
Gene: SIGMAR1
UniProt: Q99720 (SGMR1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7
Drug: amiodarone
Target: Thyroid hormone receptor alpha (Nuclear hormone receptor)
Gene: THRA
UniProt: P10827 (THA_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.64
Drug: amiodarone
Target: Thyroid hormone receptor beta (Nuclear hormone receptor)
Gene: THRB
UniProt: P10828 (THB_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.22
Drug: amiodarone
Target: Potassium voltage-gated channel subfamily H member 2 (Ion channel)
Gene: KCNH2
UniProt: Q12809 (KCNH2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5
Action type: BLOCKER
Drug: amiodarone
Target: Cytochrome P450 3A4 (Enzyme)
Gene: CYP3A4
UniProt: P08684 (CP3A4_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.22
Drug: amiodarone
Target: 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (Enzyme)
Gene: EBP
UniProt: Q15125 (EBP_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.6
Drug: amiodarone
Target: Multidrug resistance protein 1 (Transporter)
Gene: ABCB1
UniProt: P08183 (MDR1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.3
Drug: amiodarone
Target: Sodium-dependent serotonin transporter (Transporter)
Gene: SLC6A4
UniProt: P31645 (SC6A4_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.912
Assay: DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine)
Drug: amiodarone
Target: Sodium-dependent noradrenaline transporter (Transporter)
Gene: SLC6A2
UniProt: P23975 (SC6A2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.647
Assay: DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55)
Drug: amiodarone
Target: 5-hydroxytryptamine receptor 2A (GPCR)
Gene: HTR2A
UniProt: P28223 (5HT2A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.989
Assay: DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin)
Drug: amiodarone
Target: 5-hydroxytryptamine receptor 2B (GPCR)
Gene: HTR2B
UniProt: P41595 (5HT2B_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.231
Assay: DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
Drug: amiodarone
Target: 5-hydroxytryptamine receptor 2C (GPCR)
Gene: HTR2C
UniProt: P28335 (5HT2C_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.674
Assay: DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine)
Drug: amiodarone
Target: 5-hydroxytryptamine receptor 6 (GPCR)
Gene: HTR6
UniProt: P50406 (5HT6R_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.045
Assay: DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT6 radioligand binding (ligand: [3H] Lysergic acid diethylamide)
Drug: amiodarone
Target: Alpha-2B adrenergic receptor (GPCR)
Gene: ADRA2B
UniProt: P18089 (ADA2B_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.23
Assay: DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug: amiodarone
Target: D(3) dopamine receptor (GPCR)
Gene: DRD3
UniProt: P35462 (DRD3_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.387
Assay: DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone)
Drug: amiodarone
Target: Histamine H2 receptor (GPCR)
Gene: HRH2
UniProt: P25021 (HRH2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 4.984
Assay: DRUGMATRIX: Histamine H2 radioligand binding (ligand: [125I] Aminopotentidine)
Drug: amiodarone
Target: Muscarinic acetylcholine receptor M1 (GPCR)
Gene: CHRM1
UniProt: P11229 (ACM1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.201
Assay: DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine)
Drug: amiodarone
Target: Muscarinic acetylcholine receptor M2 (GPCR)
Gene: CHRM2
UniProt: P08172 (ACM2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.743
Assay: DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)
Drug: amiodarone
Target: Muscarinic acetylcholine receptor M3 (GPCR)
Gene: CHRM3
UniProt: P20309 (ACM3_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.168
Assay: DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)
Drug: amiodarone
Target: Muscarinic acetylcholine receptor M4 (GPCR)
Gene: CHRM4
UniProt: P08173 (ACM4_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.296
Assay: DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine)
Drug: amiodarone
Target: Muscarinic acetylcholine receptor M5 (GPCR)
Gene: CHRM5
UniProt: P08912 (ACM5_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.968
Assay: DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
Drug: amiodarone
Target: Beta-3 adrenergic receptor (GPCR)
Gene: ADRB3
UniProt: P13945 (ADRB3_HUMAN)
Organism: Homo sapiens
Activity: Ki = 4.498
Assay: DRUGMATRIX: Adrenergic beta3 radioligand binding (ligand: [125I] Cyanopindolol)
Drug: amiodarone
Target: Sodium-dependent dopamine transporter (Transporter)
Gene: SLC6A3
UniProt: Q01959 (SC6A3_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.701
Assay: DRUGMATRIX: Dopamine Transporter radioligand binding (ligand: [125I] RTI-55)
Drug: amiodarone
Target: Adenosine receptor A3 (GPCR)
Gene: ADORA3
UniProt: P0DMS8 (AA3R_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.004
Assay: DRUGMATRIX: Adenosine A3 radioligand binding (ligand: AB-MECA)
Drug: amiodarone
Target: D(4) dopamine receptor (GPCR)
Gene: DRD4
UniProt: P21917 (DRD4_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.207
Assay: DRUGMATRIX: Dopamine D4.2 radioligand binding (ligand: [3H] Spiperone)
Drug: amiodarone
Target: Kappa-type opioid receptor (GPCR)
Gene: OPRK1
UniProt: P41145 (OPRK_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.176
Assay: DRUGMATRIX: Opiate kappa (OP2, KOP) radioligand binding (ligand: [3H] Diprenorphine)
Drug: amiodarone
Target: Delta-type opioid receptor (GPCR)
Gene: OPRD1
UniProt: P41143 (OPRD_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.549
Assay: DRUGMATRIX: Opiate delta1 (OP1, DOP) radioligand binding (ligand: [3H] Naltrindole)
Drug: amiodarone
Target: Cytochrome P450 2C9 (Enzyme)
Gene: CYP2C9
UniProt: P11712 (CP2C9_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 7.398
Drug: amiodarone
Target: Voltage-dependent T-type calcium channel subunit alpha-1H (Ion channel)
Gene: CACNA1H
UniProt: O95180 (CAC1H_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.284
Drug: amiodarone
Target: Endothelin-1 receptor (GPCR)
Gene: EDNRA
UniProt: P25101 (EDNRA_HUMAN)
Organism: Homo sapiens
Activity: Ki = 4.791
Assay: DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)
Drug: amiodarone
Target: Squalene monooxygenase (Enzyme)
Gene: SQLE
UniProt: Q14534 (ERG1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.92
Assay: Inhibitory activity against Trypanosoma cruzi microsomal squalene synthase
Drug: amiodarone
Target: Tyrosine-protein kinase Fyn (Kinase)
Gene: FYN
UniProt: P06241 (FYN_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.088
Assay: DRUGMATRIX: Protein Tyrosine Kinase, Fyn enzyme inhibition (substrate: Poly(Glu:Tyr))
Drug: amiodarone
Target: Receptor tyrosine-protein kinase erbB-2 (Kinase)
Gene: ERBB2
UniProt: P04626 (ERBB2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.039
Assay: DRUGMATRIX: Protein Tyrosine Kinase, ERBB2 (HER2) enzyme inhibition (substrate: Poly(Glu:Tyr))
Drug: amiodarone
Target: Squalene synthase (Enzyme)
Gene: FDFT1
UniProt: P37268 (FDFT_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.1
Assay: Inhibitory activity against Trypanosoma cruzi glycosomal squalene synthase
Drug: amiodarone
Target: C-C chemokine receptor type 2 (GPCR)
Gene: CCR2
UniProt: P41597 (CCR2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.368
Assay: DRUGMATRIX: Chemokine CCR2B  radioligand binding (ligand: [125I] MCP-1)
Drug: amiodarone
Target: Substance-K receptor (GPCR)
Gene: TACR2
UniProt: P21452 (NK2R_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.191
Assay: DRUGMATRIX: Tachykinin NK2  radioligand binding (ligand: [3H] SR-48968)
Drug: amiodarone
Target: Androgen receptor (Transcription factor)
Gene: Ar
UniProt: P15207 (ANDR_RAT)
Organism: Rattus norvegicus
Activity: Ki = 4.55
Assay: DRUGMATRIX: Androgen (Testosterone) AR radioligand binding (ligand: [3H] Mibolerone)
Drug: amiodarone
Target: Lethal factor (Enzyme)
Gene: lef
UniProt: P15917 (LEF_BACAN)
Organism: Bacillus anthracis
Activity: IC50 = 5.46
Assay: Protection against Bacillus anthracis lethal toxin-mediated cytotoxicity in mouse RAW264.7 cells assessed as change in viability after 24 hrs by WST1 dye reduction assay
Drug: amiodarone
Target: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (Ion channel)
Gene: HCN4
UniProt: Q9Y3Q4 (HCN4_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.347
Drug: amiodarone
Target: Potassium voltage-gated channel subfamily A member 7 (Ion channel)
Gene: KCNA7
UniProt: Q96RP8 (KCNA7_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6
Drug: amiodarone
Target: 5-hydroxytryptamine receptor 1B (GPCR)
Gene: Htr1b
UniProt: P28564 (5HT1B_RAT)
Organism: Rattus norvegicus
Activity: Ki = 4.407
Assay: DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)
Drug: amiodarone
Target: B2 bradykinin receptor (GPCR)
Gene: BDKRB2
UniProt: P30411 (BKRB2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.115
Assay: DRUGMATRIX: Bradykinin B2 radioligand binding (ligand: [3H] Bradykinin)
Drug: amiodarone
Target: Melanocortin receptor 4 (GPCR)
Gene: MC4R
UniProt: P32245 (MC4R_HUMAN)
Organism: Homo sapiens
Activity: Ki = 4.879
Assay: DRUGMATRIX: Melanocortin MC4 radioligand binding (ligand: [125I] NDP-alpha-MSH)
Drug: amiodarone
Target: Melanocortin receptor 5 (GPCR)
Gene: MC5R
UniProt: P33032 (MC5R_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.05
Assay: DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)
Drug: amiodarone
Target: Melanocortin receptor 3 (GPCR)
Gene: MC3R
UniProt: P41968 (MC3R_HUMAN)
Organism: Homo sapiens
Activity: Ki = 4.967
Assay: DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)
Drug: amiodarone
Target: C-C chemokine receptor type 4 (GPCR)
Gene: CCR4
UniProt: P51679 (CCR4_HUMAN)
Organism: Homo sapiens
Activity: Ki = 4.943
Assay: DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)
Drug: amiodarone
Target: Membrane-associated progesterone receptor component 1 (Membrane receptor)
Gene: Pgrmc1
UniProt: P70580 (PGRC1_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 6.932
Assay: DRUGMATRIX: Sigma2 radioligand binding (ligand: [3H] Ifenprodil)
Drug: amiodarone
Target: C-8 sterol isomerase (Enzyme)
Gene: ERG2
UniProt: P32352 (ERG2_YEAST)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Activity: Ki = 7.21
Assay: Affinity for ERG2 of Saccharomyces cerevisiae using [3H]ifenprodil or (+)-[3H]pentazocine radioligand
Drug: amiodarone
Target: Cruzipain (Enzyme)
UniProt: P25779 (CYSP_TRYCR)
Organism: Trypanosoma cruzi
Activity: IC50 = 5.4
Assay: Inhibition of Trypanosoma cruzi cruzaine preincubated for 5 mins before substrate addition by fluorescence assay in absence of Triton X-100
Drug: amiodarone
Target: THAP domain-containing protein 1 (Unclassified)
Gene: THAP1
UniProt: Q9NVV9 (THAP1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.19
Drug: amiodarone
Target: Sodium channel protein type 5 subunit alpha (Ion channel)
Gene: Scn5a
UniProt: P15389 (SCN5A_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 5.7
Action type: BLOCKER