AIM-Harvard/TrialPanorama-filtered huggingface dataset:
Drug: teneligliptin
Target: Dipeptidyl peptidase 8 (Enzyme)
Gene: DPP8
UniProt: Q6V1X1 (DPP8_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.585
Drug: teneligliptin
Target: Dipeptidyl peptidase 9 (Enzyme)
Gene: DPP9
UniProt: Q86TI2 (DPP9_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.268
Drug: teneligliptin
Target: Dipeptidyl peptidase 4 (Enzyme)
Gene: DPP4
UniProt: P27487 (DPP4_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 9.432
Action type: INHIBITOR
Drug: anagliptin
Target: Prolyl endopeptidase FAP (Enzyme)
Gene: FAP
UniProt: Q12884 (SEPR_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.14
Assay: Inhibition of human recombinant FAP expressed in baculovirus-infected Sf9 insect cells using H-Ala-Pro-AFC as substrate after 60 mins by fluorescence assay
Drug: anagliptin
Target: Dipeptidyl peptidase 8 (Enzyme)
Gene: DPP8
UniProt: Q6V1X1 (DPP8_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7.167
Drug: anagliptin
Target: Dipeptidyl peptidase 9 (Enzyme)
Gene: DPP9
UniProt: Q86TI2 (DPP9_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7.222
Drug: anagliptin
Target: Dipeptidyl peptidase 4 (Enzyme)
Gene: DPP4
UniProt: P27487 (DPP4_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 8.42
Action type: INHIBITOR
Drug: edoxaban
Target: Coagulation factor X (Enzyme)
Gene: F10
UniProt: P00742 (FA10_HUMAN)
Organism: Homo sapiens
Activity: Ki = 9.252
Action type: INHIBITOR
Drug: netupitant
Target: Substance-P receptor (GPCR)
Gene: TACR1
UniProt: P25103 (NK1R_HUMAN)
Organism: Homo sapiens
Activity: Ki = 9.022
Action type: ANTAGONIST
Assay: displacement of [3H]-labelled substance P from cloned human receptor expressed in CHO cells
Drug: ledipasvir
Target: Nonstructural protein 5A (Unclassified)
Gene: NS5A
UniProt: Q5L478 (Q5L478_9HEPC)
Organism: Hepatitis C virus
Activity: EC50 = 10.51
Assay: Inhibition of NS5A in HCV genotype 1a H77 infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luciferase reporter gene assay
Drug: ledipasvir
Target: Genome polyprotein (Polyprotein)
UniProt: P26663 (POLG_HCVBK)
Organism: Hepatitis C virus genotype 1b (isolate BK)
Activity: EC50 = 11.398
Action type: INHIBITOR
Assay: replicon antiviral assay
Drug: ledipasvir
Target: Genome polyprotein (Polyprotein)
UniProt: P27958 (POLG_HCVH)
Organism: Hepatitis C virus genotype 1a (isolate H)
Activity: EC50 = 10.509
Action type: INHIBITOR
Assay: replicon antiviral assay
Drug: diquafosol
Target: P2Y purinoceptor 4 (GPCR)
Gene: P2RY4
UniProt: P51582 (P2RY4_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 6.4
Action type: AGONIST
Drug: diquafosol
Target: P2Y purinoceptor 2 (GPCR)
Gene: P2RY2
UniProt: P41231 (P2RY2_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 7.469
Action type: AGONIST
Drug: insulin glargine
Target: Insulin receptor (Kinase)
Gene: INSR
UniProt: P06213 (INSR_HUMAN)
Organism: Homo sapiens
Action type: AGONIST
Assay: Mechanism of Action
Drug: imidafenacin
Target: Muscarinic acetylcholine receptor M1 (GPCR)
Gene: CHRM1
UniProt: P11229 (ACM1_HUMAN)
Organism: Homo sapiens
Activity: Kb = 8.384
Drug: imidafenacin
Target: Muscarinic acetylcholine receptor M3 (GPCR)
Gene: CHRM3
UniProt: P20309 (ACM3_HUMAN)
Organism: Homo sapiens
Activity: Kb = 9.499
Action type: ANTAGONIST
Drug: nintedanib
Target: Tyrosine-protein kinase JAK3 (Kinase)
Gene: JAK3
UniProt: P52333 (JAK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.09
Assay: Binding constant for JAK3(JH1domain-catalytic) kinase domain
Drug: nintedanib
Target: Potassium voltage-gated channel subfamily H member 2 (Ion channel)
Gene: KCNH2
UniProt: Q12809 (KCNH2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 8.59
Assay: Inhibition of human ERG
Drug: nintedanib
Target: Multidrug resistance protein 1 (Transporter)
Gene: ABCB1
UniProt: P08183 (MDR1_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 6.56
Assay: Inhibition of ABCB1 in human A2780/ADR cells assessed as potentiation of daunorubicin-induced cytotoxicity measured after 72 hrs by MTT assay
Drug: nintedanib
Target: Platelet-derived growth factor receptor beta (Kinase)
Gene: PDGFRB
UniProt: P09619 (PGFRB_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.82
Action type: INHIBITOR
Assay: Binding constant for PDGFRB kinase domain
Drug: nintedanib
Target: Tyrosine-protein kinase ABL1 (Kinase)
Gene: ABL1
UniProt: P00519 (ABL1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8
Assay: Binding constant for ABL1(T315I)-phosphorylated kinase domain
Drug: nintedanib
Target: Mast/stem cell growth factor receptor Kit (Kinase)
Gene: KIT
UniProt: P10721 (KIT_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.57
Assay: Binding constant for KIT(L576P) kinase domain
Drug: nintedanib
Target: Proto-oncogene tyrosine-protein kinase Src (Kinase)
Gene: SRC
UniProt: P12931 (SRC_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.24
Assay: Binding constant for SRC kinase domain
Drug: nintedanib
Target: Tyrosine-protein kinase Lck (Kinase)
Gene: LCK
UniProt: P06239 (LCK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.21
Assay: Binding constant for LCK kinase domain
Drug: nintedanib
Target: Tyrosine-protein kinase Yes (Kinase)
Gene: YES1
UniProt: P07947 (YES_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.1
Assay: Binding constant for YES kinase domain
Drug: nintedanib
Target: Tyrosine-protein kinase Fyn (Kinase)
Gene: FYN
UniProt: P06241 (FYN_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.2
Assay: Binding constant for FYN kinase domain
Drug: nintedanib
Target: Ephrin type-A receptor 2 (Kinase)
Gene: EPHA2
UniProt: P29317 (EPHA2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.54
Assay: Binding constant for EPHA2 kinase domain
Drug: nintedanib
Target: Receptor-type tyrosine-protein kinase FLT3 (Kinase)
Gene: FLT3
UniProt: P36888 (FLT3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 9.38
Assay: Binding constant for FLT3(D835Y) kinase domain
Drug: nintedanib
Target: Proto-oncogene tyrosine-protein kinase receptor Ret (Kinase)
Gene: RET
UniProt: P07949 (RET_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.02
Assay: Binding constant for RET(V804M) kinase domain
Drug: nintedanib
Target: Macrophage colony-stimulating factor 1 receptor (Kinase)
Gene: CSF1R
UniProt: P07333 (CSF1R_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.32
Assay: Binding constant for CSF1R kinase domain
Drug: nintedanib
Target: Ribosomal protein S6 kinase alpha-3 (Kinase)
Gene: RPS6KA3
UniProt: P51812 (KS6A3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.19
Assay: Binding constant for RSK2(Kin.Dom.1-N-terminal) kinase domain
Drug: nintedanib
Target: Phosphorylase b kinase gamma catalytic chain, liver/testis isoform (Kinase)
Gene: PHKG2
UniProt: P15735 (PHKG2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.59
Assay: Binding constant for PHKG2 kinase domain
Drug: nintedanib
Target: Cyclin-dependent kinase 2 (Kinase)
Gene: CDK2
UniProt: P24941 (CDK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.85
Assay: Binding constant for CDK2 kinase domain
Drug: nintedanib
Target: Insulin-like growth factor 1 receptor (Kinase)
Gene: IGF1R
UniProt: P08069 (IGF1R_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.21
Assay: Binding constant for IGF1R kinase domain
Drug: nintedanib
Target: Myosin light chain kinase, smooth muscle (Kinase)
Gene: MYLK
UniProt: Q15746 (MYLK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.54
Assay: Binding constant for MYLK kinase domain
Drug: nintedanib
Target: Insulin receptor (Kinase)
Gene: INSR
UniProt: P06213 (INSR_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.62
Action type: AGONIST
Assay: Binding constant for INSR kinase domain
Drug: nintedanib
Target: Death-associated protein kinase 3 (Kinase)
Gene: DAPK3
UniProt: O43293 (DAPK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.68
Assay: Binding constant for DAPK3 kinase domain
Drug: nintedanib
Target: Calcium/calmodulin-dependent protein kinase type 1 (Kinase)
Gene: CAMK1
UniProt: Q14012 (KCC1A_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.23
Assay: Binding constant for CAMK1 kinase domain
Drug: nintedanib
Target: Mitogen-activated protein kinase 8 (Kinase)
Gene: MAPK8
UniProt: P45983 (MK08_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.2
Assay: Binding constant for JNK1 kinase domain
Drug: nintedanib
Target: Fibroblast growth factor receptor 3 (Kinase)
Gene: FGFR3
UniProt: P22607 (FGFR3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.03
Action type: INHIBITOR
Assay: Binding constant for FGFR3 kinase domain
Drug: nintedanib
Target: Focal adhesion kinase 1 (Kinase)
Gene: PTK2
UniProt: Q05397 (FAK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.68
Assay: Binding constant for FAK kinase domain
Drug: nintedanib
Target: Tyrosine-protein kinase HCK (Kinase)
Gene: HCK
UniProt: P08631 (HCK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.28
Assay: Binding constant for HCK kinase domain
Drug: nintedanib
Target: Tyrosine-protein kinase JAK1 (Kinase)
Gene: JAK1
UniProt: P23458 (JAK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.32
Assay: Binding constant for JAK1(JH2domain-pseudokinase) kinase domain
Drug: nintedanib
Target: Mitogen-activated protein kinase 10 (Kinase)
Gene: MAPK10
UniProt: P53779 (MK10_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.57
Assay: Binding constant for JNK3 kinase domain
Drug: nintedanib
Target: Death-associated protein kinase 2 (Kinase)
Gene: DAPK2
UniProt: Q9UIK4 (DAPK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.49
Assay: Binding constant for DAPK2 kinase domain
Drug: nintedanib
Target: High affinity nerve growth factor receptor (Kinase)
Gene: NTRK1
UniProt: P04629 (NTRK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.35
Assay: Binding constant for TRKA kinase domain
Drug: nintedanib
Target: Tyrosine-protein kinase JAK2 (Kinase)
Gene: JAK2
UniProt: O60674 (JAK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.85
Assay: Binding constant for JAK2(JH1domain-catalytic) kinase domain
Drug: nintedanib
Target: Myosin light chain kinase 2, skeletal/cardiac muscle (Kinase)
Gene: MYLK2
UniProt: Q9H1R3 (MYLK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.4
Assay: Binding constant for MYLK2 kinase domain
Drug: nintedanib
Target: Angiopoietin-1 receptor (Kinase)
Gene: TEK
UniProt: Q02763 (TIE2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.85
Assay: Binding constant for TIE2 kinase domain
Drug: nintedanib
Target: AP2-associated protein kinase 1 (Kinase)
Gene: AAK1
UniProt: Q2M2I8 (AAK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.2
Assay: Binding constant for AAK1 kinase domain
Drug: nintedanib
Target: Serine/threonine-protein kinase MARK2 (Kinase)
Gene: MARK2
UniProt: Q7KZI7 (MARK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.85
Assay: Binding constant for MARK2 kinase domain
Drug: nintedanib
Target: Hepatocyte growth factor receptor (Kinase)
Gene: MET
UniProt: P08581 (MET_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.7
Assay: Binding constant for MET kinase domain
Drug: nintedanib
Target: Tyrosine-protein kinase Lyn (Kinase)
Gene: LYN
UniProt: P07948 (LYN_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.03
Assay: Binding constant for LYN kinase domain
Drug: nintedanib
Target: Ribosomal protein S6 kinase alpha-2 (Kinase)
Gene: RPS6KA2
UniProt: Q15349 (KS6A2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.24
Assay: Binding constant for RSK3(Kin.Dom.1-N-terminal) kinase domain
Drug: nintedanib
Target: 5'-AMP-activated protein kinase catalytic subunit alpha-1 (Kinase)
Gene: PRKAA1
UniProt: Q13131 (AAPK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.06
Assay: Binding constant for AMPK-alpha1 kinase domain
Drug: nintedanib
Target: Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform (Kinase)
Gene: PHKG1
UniProt: Q16816 (PHKG1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.85
Assay: Binding constant for PHKG1 kinase domain
Drug: nintedanib
Target: Calcium/calmodulin-dependent protein kinase type II subunit alpha (Kinase)
Gene: CAMK2A
UniProt: Q9UQM7 (KCC2A_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.44
Assay: Binding constant for CAMK2A kinase domain
Drug: nintedanib
Target: Serine/threonine-protein kinase 17B (Kinase)
Gene: STK17B
UniProt: O94768 (ST17B_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.17
Assay: Binding constant for DRAK2 kinase domain
Drug: nintedanib
Target: Serine/threonine-protein kinase 10 (Kinase)
Gene: STK10
UniProt: O94804 (STK10_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.06
Assay: Binding constant for LOK kinase domain
Drug: nintedanib
Target: Tyrosine-protein kinase Fer (Kinase)
Gene: FER
UniProt: P16591 (FER_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.14
Assay: Binding constant for FER kinase domain
Drug: nintedanib
Target: Serine/threonine-protein kinase PLK4 (Kinase)
Gene: PLK4
UniProt: O00444 (PLK4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.28
Assay: Binding constant for PLK4 kinase domain
Drug: nintedanib
Target: Aurora kinase C (Kinase)
Gene: AURKC
UniProt: Q9UQB9 (AURKC_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.72
Assay: Binding constant for AURKC kinase domain
Drug: nintedanib
Target: Serine/threonine-protein kinase 16 (Kinase)
Gene: STK16
UniProt: O75716 (STK16_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.74
Assay: Binding constant for STK16 kinase domain
Drug: nintedanib
Target: Dual specificity protein kinase TTK (Kinase)
Gene: TTK
UniProt: P33981 (TTK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.66
Assay: Binding constant for TTK kinase domain
Drug: nintedanib
Target: Abelson tyrosine-protein kinase 2 (Kinase)
Gene: ABL2
UniProt: P42684 (ABL2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.7
Assay: Binding constant for ABL2 kinase domain
Drug: nintedanib
Target: Fibroblast growth factor receptor 2 (Kinase)
Gene: FGFR2
UniProt: P21802 (FGFR2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.46
Action type: INHIBITOR
Assay: Binding constant for FGFR2 kinase domain
Drug: nintedanib
Target: Serine/threonine-protein kinase N1 (Kinase)
Gene: PKN1
UniProt: Q16512 (PKN1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.13
Assay: Binding constant for PKN1 kinase domain
Drug: nintedanib
Target: Protein kinase C theta type (Kinase)
Gene: PRKCQ
UniProt: Q04759 (KPCT_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.26
Assay: Binding constant for PRKCQ kinase domain
Drug: nintedanib
Target: Serine/threonine-protein kinase 17A (Kinase)
Gene: STK17A
UniProt: Q9UEE5 (ST17A_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.96
Assay: Binding constant for DRAK1 kinase domain
Drug: nintedanib
Target: Ephrin type-A receptor 6 (Kinase)
Gene: EPHA6
UniProt: Q9UF33 (EPHA6_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.03
Assay: Binding constant for EPHA6 kinase domain
Drug: nintedanib
Target: TRAF2 and NCK-interacting protein kinase (Kinase)
Gene: TNIK
UniProt: Q9UKE5 (TNIK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.28
Assay: Binding constant for TNIK kinase domain
Drug: nintedanib
Target: Casein kinase I isoform epsilon (Kinase)
Gene: CSNK1E
UniProt: P49674 (KC1E_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.64
Assay: Binding constant for CSNK1E kinase domain
Drug: nintedanib
Target: Tyrosine-protein kinase Fgr (Kinase)
Gene: FGR
UniProt: P09769 (FGR_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.52
Assay: Binding constant for FGR kinase domain
Drug: nintedanib
Target: ALK tyrosine kinase receptor (Kinase)
Gene: ALK
UniProt: Q9UM73 (ALK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.51
Assay: Binding constant for ALK kinase domain
Drug: nintedanib
Target: Ephrin type-A receptor 3 (Kinase)
Gene: EPHA3
UniProt: P29320 (EPHA3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.07
Assay: Binding constant for EPHA3 kinase domain
Drug: nintedanib
Target: BMP-2-inducible protein kinase (Kinase)
Gene: BMP2K
UniProt: Q9NSY1 (BMP2K_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.66
Assay: Binding constant for BIKE kinase domain
Drug: nintedanib
Target: Tyrosine-protein kinase FRK (Kinase)
Gene: FRK
UniProt: P42685 (FRK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.57
Assay: Binding constant for FRK kinase domain
Drug: nintedanib
Target: Dual specificity protein kinase CLK1 (Kinase)
Gene: CLK1
UniProt: P49759 (CLK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.06
Assay: Binding constant for CLK1 kinase domain
Drug: nintedanib
Target: Dual specificity protein kinase CLK2 (Kinase)
Gene: CLK2
UniProt: P49760 (CLK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.12
Assay: Binding constant for CLK2 kinase domain
Drug: nintedanib
Target: Mitogen-activated protein kinase kinase kinase kinase 5 (Kinase)
Gene: MAP4K5
UniProt: Q9Y4K4 (M4K5_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.41
Assay: Binding constant for MAP4K5 kinase domain
Drug: nintedanib
Target: Glycogen synthase kinase-3 beta (Kinase)
Gene: GSK3B
UniProt: P49841 (GSK3B_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.08
Assay: Binding constant for GSK3B kinase domain
Drug: nintedanib
Target: Ephrin type-B receptor 1 (Kinase)
Gene: EPHB1
UniProt: P54762 (EPHB1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.26
Assay: Binding constant for EPHB1 kinase domain
Drug: nintedanib
Target: Calcium/calmodulin-dependent protein kinase type 1D (Kinase)
Gene: CAMK1D
UniProt: Q8IU85 (KCC1D_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.66
Assay: Binding constant for CAMK1D kinase domain
Drug: nintedanib
Target: Cyclin-dependent kinase 16 (Kinase)
Gene: CDK16
UniProt: Q00536 (CDK16_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.68
Assay: Binding constant for PCTK1 kinase domain
Drug: nintedanib
Target: Serine/threonine-protein kinase 4 (Kinase)
Gene: STK4
UniProt: Q13043 (STK4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.05
Assay: Binding constant for MST1 kinase domain
Drug: nintedanib
Target: Activated CDC42 kinase 1 (Kinase)
Gene: TNK2
UniProt: Q07912 (ACK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.8
Assay: Binding constant for TNK2 kinase domain
Drug: nintedanib
Target: Ribosomal protein S6 kinase alpha-5 (Kinase)
Gene: RPS6KA5
UniProt: O75582 (KS6A5_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.7
Assay: Binding constant for RPS6KA5(Kin.Dom.1-N-terminal) kinase domain
Drug: nintedanib
Target: STE20-like serine/threonine-protein kinase (Kinase)
Gene: SLK
UniProt: Q9H2G2 (SLK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.29
Assay: Binding constant for SLK kinase domain
Drug: nintedanib
Target: Dual specificity protein kinase CLK4 (Kinase)
Gene: CLK4
UniProt: Q9HAZ1 (CLK4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.74
Assay: Binding constant for CLK4 kinase domain
Drug: nintedanib
Target: Calcium/calmodulin-dependent protein kinase kinase 2 (Kinase)
Gene: CAMKK2
UniProt: Q96RR4 (KKCC2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.04
Assay: Binding constant for CAMKK2 kinase domain
Drug: nintedanib
Target: MAP/microtubule affinity-regulating kinase 3 (Kinase)
Gene: MARK3
UniProt: P27448 (MARK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.11
Assay: Binding constant for MARK3 kinase domain
Drug: nintedanib
Target: Calcium/calmodulin-dependent protein kinase kinase 1 (Kinase)
Gene: CAMKK1
UniProt: Q8N5S9 (KKCC1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.2
Assay: Binding constant for CAMKK1 kinase domain
Drug: nintedanib
Target: Calcium/calmodulin-dependent protein kinase type 1G (Kinase)
Gene: CAMK1G
UniProt: Q96NX5 (KCC1G_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.59
Assay: Binding constant for CAMK1G kinase domain
Drug: nintedanib
Target: Epithelial discoidin domain-containing receptor 1 (Kinase)
Gene: DDR1
UniProt: Q08345 (DDR1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.92
Assay: Binding constant for DDR1 kinase domain
Drug: nintedanib
Target: Ephrin type-B receptor 4 (Kinase)
Gene: EPHB4
UniProt: P54760 (EPHB4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.96
Assay: Binding constant for EPHB4 kinase domain
Drug: nintedanib
Target: Testis-specific serine/threonine-protein kinase 1 (Kinase)
Gene: TSSK1B
UniProt: Q9BXA7 (TSSK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.21
Assay: Binding constant for TSSK1B kinase domain
Drug: nintedanib
Target: Activin receptor type-1B (Kinase)
Gene: ACVR1B
UniProt: P36896 (ACV1B_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.31
Assay: Binding constant for ACVR1B kinase domain
Drug: nintedanib
Target: Serine/threonine-protein kinase receptor R3 (Kinase)
Gene: ACVRL1
UniProt: P37023 (ACVL1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.38
Assay: Binding constant for ACVRL1 kinase domain
Drug: nintedanib
Target: Activin receptor type-1 (Kinase)
Gene: ACVR1
UniProt: Q04771 (ACVR1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.22
Assay: Binding constant for ACVR1 kinase domain
Drug: nintedanib
Target: 3-phosphoinositide-dependent protein kinase 1 (Kinase)
Gene: PDPK1
UniProt: O15530 (PDPK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.55
Assay: Binding constant for PDPK1 kinase domain
Drug: nintedanib
Target: Dual specificity mitogen-activated protein kinase kinase 1 (Kinase)
Gene: MAP2K1
UniProt: Q02750 (MP2K1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8
Assay: Binding constant for MEK1 kinase domain
Drug: nintedanib
Target: Dual specificity mitogen-activated protein kinase kinase 2 (Kinase)
Gene: MAP2K2
UniProt: P36507 (MP2K2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.38
Assay: Binding constant for MEK2 kinase domain
Drug: nintedanib
Target: Tyrosine-protein kinase ITK/TSK (Kinase)
Gene: ITK
UniProt: Q08881 (ITK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.68
Assay: Binding constant for ITK kinase domain
Drug: nintedanib
Target: Tyrosine-protein kinase ZAP-70 (Kinase)
Gene: ZAP70
UniProt: P43403 (ZAP70_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.46
Assay: Binding constant for ZAP70 kinase domain
Drug: nintedanib
Target: Glycogen synthase kinase-3 alpha (Kinase)
Gene: GSK3A
UniProt: P49840 (GSK3A_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.37
Assay: Binding constant for GSK3A kinase domain
Drug: nintedanib
Target: Tyrosine-protein kinase BTK (Kinase)
Gene: BTK
UniProt: Q06187 (BTK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.51
Assay: Binding constant for BTK kinase domain
Drug: nintedanib
Target: Tyrosine-protein kinase receptor UFO (Kinase)
Gene: AXL
UniProt: P30530 (UFO_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.92
Assay: Binding constant for AXL kinase domain
Drug: nintedanib
Target: BDNF/NT-3 growth factors receptor (Kinase)
Gene: NTRK2
UniProt: Q16620 (NTRK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.72
Assay: Binding constant for TRKB kinase domain
Drug: nintedanib
Target: Tyrosine-protein kinase receptor TYRO3 (Kinase)
Gene: TYRO3
UniProt: Q06418 (TYRO3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.31
Assay: Binding constant for TYRO3 kinase domain
Drug: nintedanib
Target: Cyclin-dependent kinase 7 (Kinase)
Gene: CDK7
UniProt: P50613 (CDK7_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.52
Assay: Binding constant for CDK7 kinase domain
Drug: nintedanib
Target: Serine/threonine-protein kinase D1 (Kinase)
Gene: PRKD1
UniProt: Q15139 (KPCD1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6
Assay: Binding constant for PRKD1 kinase domain
Drug: nintedanib
Target: Ribosomal protein S6 kinase beta-1 (Kinase)
Gene: RPS6KB1
UniProt: P23443 (KS6B1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.72
Assay: Binding constant for S6K1 kinase domain
Drug: nintedanib
Target: Serine/threonine-protein kinase N2 (Kinase)
Gene: PKN2
UniProt: Q16513 (PKN2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.85
Assay: Binding constant for PKN2 kinase domain
Drug: nintedanib
Target: Serine/threonine-protein kinase DCLK3 (Kinase)
Gene: DCLK3
UniProt: Q9C098 (DCLK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.11
Assay: Binding constant for DCAMKL3 kinase domain
Drug: nintedanib
Target: Serine/threonine-protein kinase 3 (Kinase)
Gene: STK3
UniProt: Q13188 (STK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.42
Assay: Binding constant for MST2 kinase domain
Drug: nintedanib
Target: Ribosomal protein S6 kinase alpha-6 (Kinase)
Gene: RPS6KA6
UniProt: Q9UK32 (KS6A6_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.64
Assay: Binding constant for RSK4(Kin.Dom.1-N-terminal) kinase domain
Drug: nintedanib
Target: NUAK family SNF1-like kinase 2 (Kinase)
Gene: NUAK2
UniProt: Q9H093 (NUAK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.68
Assay: Binding constant for SNARK kinase domain
Drug: nintedanib
Target: Non-receptor tyrosine-protein kinase TNK1 (Kinase)
Gene: TNK1
UniProt: Q13470 (TNK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.68
Assay: Binding constant for TNK1 kinase domain