AIM-Harvard/TrialPanorama-filtered huggingface dataset:
Drug: tirofiban
Target: Integrin alpha-IIb/beta-3 (Adhesion)
Gene: ITGB3|ITGA2B
UniProt: P05106|P08514 (ITB3_HUMAN|ITA2B_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7.959
Action type: INHIBITOR
Drug: tizanidine
Target: Alpha-2A adrenergic receptor (GPCR)
Gene: ADRA2A
UniProt: P08913 (ADA2A_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 7.07
Action type: AGONIST
Assay: Agonist activity at human recombinant alpha-2A receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassay
Drug: tizanidine
Target: Alpha-2B adrenergic receptor (GPCR)
Gene: ADRA2B
UniProt: P18089 (ADA2B_HUMAN)
Organism: Homo sapiens
Action type: AGONIST
Drug: tizanidine
Target: Alpha-2C adrenergic receptor (GPCR)
Gene: ADRA2C
UniProt: P18825 (ADA2C_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 5.91
Action type: AGONIST
Assay: Agonist activity at human recombinant alpha-2C receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassay
Drug: tizanidine
Target: Nischarin (Membrane receptor)
Gene: NISCH
UniProt: Q9Y2I1 (NISCH_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.55
Assay: Displacement of [125I]PIC from human imidazoline receptor 1 in human platelets analyzed under norepinephrine mask of alpha 2AR
Drug: tizanidine
Target: Alpha-1A adrenergic receptor (GPCR)
Gene: ADRA1A
UniProt: P18130 (ADA1A_BOVIN)
Organism: Bos taurus
Activity: EC50 = 6.58
Assay: Agonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assay
Drug: tizanidine
Target: Alpha-1B adrenergic receptor (GPCR)
UniProt: G3HDX1 (G3HDX1_CRIGR)
Organism: Cricetulus griseus
Activity: EC50 = 6.49
Assay: Agonist activity at hamster recombinant alpha-1B receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assay
Drug: tobramycin
Target: Macrolide 2'-phosphotransferase II; Macrolide 2'-phosphotransferase II protein MphB; Macrolide 2-phosphotransferase, mph(B) (Enzyme)
Gene: mphB
UniProt: O32553 (O32553_ECOLX)
Organism: Escherichia coli
Activity: Km = 5.824
Drug: tocainide
Target: Sodium channel alpha subunit (Ion channel)
Gene: SCN1A|SCN4A|SCN7A|SCN5A|SCN9A|SCN2A|SCN3A|SCN11A|SCN8A|SCN10A
UniProt: P35498|P35499|Q01118|Q14524|Q15858|Q99250|Q9NY46|Q9UI33|Q9UQD0|Q9Y5Y9 (SCN1A_HUMAN|SCN4A_HUMAN|SCN7A_HUMAN|SCN5A_HUMAN|SCN9A_HUMAN|SCN2A_HUMAN|SCN3A_HUMAN|SCNBA_HUMAN|SCN8A_HUMAN|SCNAA_HUMAN)
Organism: Homo sapiens
Action type: BLOCKER
Assay: Mechanism of Action
Drug: tofisopam
Target: cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Enzyme)
Gene: PDE4D
UniProt: Q08499 (PDE4D_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.05
Assay: Inhibition of human PDE4D catalytic domain using [3H]-cAMP or [3H]-cGMP incubated for 30 mins by scintillation counting method
Drug: tolazamide
Target: Arachidonate 15-lipoxygenase (Enzyme)
Gene: ALOX15
UniProt: P12530 (LOX15_RABIT)
Organism: Oryctolagus cuniculus
Activity: IC50 = 5.292
Assay: DRUGMATRIX: Lipoxygenase 15-LO enzyme inhibition (substrate: Linoleic acid)
Drug: tolazamide
Target: Sulfonylurea receptor 1, Kir6.2 (Ion channel)
Gene: ABCC8|KCNJ11
UniProt: Q09428|Q14654 (ABCC8_HUMAN|KCJ11_HUMAN)
Organism: Homo sapiens
Action type: BLOCKER
Assay: Mechanism of Action; CHEMBL2096972; PROTEIN COMPLEX
Drug: tolazoline
Target: Alpha-2A adrenergic receptor (GPCR)
Gene: ADRA2A
UniProt: P08913 (ADA2A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.64
Action type: ANTAGONIST
Drug: tolazoline
Target: Alpha-1A adrenergic receptor (GPCR)
Gene: ADRA1A
UniProt: P35348 (ADA1A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.5
Action type: ANTAGONIST
Drug: tolazoline
Target: Alpha-2B adrenergic receptor (GPCR)
Gene: ADRA2B
UniProt: P18089 (ADA2B_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.5
Action type: ANTAGONIST
Drug: tolazoline
Target: Alpha-2C adrenergic receptor (GPCR)
Gene: ADRA2C
UniProt: P18825 (ADA2C_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.43
Action type: ANTAGONIST
Drug: tolazoline
Target: Trace amine-associated receptor 1 (GPCR)
Gene: TAAR1
UniProt: Q96RJ0 (TAAR1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.79
Assay: Displacement of (S)-4-(2,4-difluorophenyl-3-tritio) -4,5-dihydro-2-oxazolamine from human TAAR1 receptor expressed in HEK293 cells after 90 mins by beta counting analysis
Drug: tolazoline
Target: Adrenergic receptor alpha-2 (GPCR)
Gene: Adra2b|Adra2c|Adra2a
UniProt: P19328|P22086|P22909 (ADA2B_RAT|ADA2C_RAT|ADA2A_RAT)
Organism: Rattus norvegicus
Activity: Ki = 6.74
Assay: Displacement of [3H]clonidine from Alpha-2 adrenergic receptor of rat brain membranes
Drug: tolazoline
Target: Adrenergic receptor alpha-1 (GPCR)
Gene: Adra1b|Adra1d|Adra1a
UniProt: P15823|P23944|P43140 (ADA1B_RAT|ADA1D_RAT|ADA1A_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 5.68
Assay: Inhibition of specific [3H]-prazosin binding (0.2 nM) to rat brain membranes alpha1 adrenoceptor; 2.1*10e-6
Drug: tolbutamide
Target: Solute carrier family 22 member 6 (Transporter)
Gene: Slc22a6
UniProt: O35956 (S22A6_RAT)
Organism: Rattus norvegicus
Activity: Ki = 4.26
Assay: Inhibition of rat Oat1 expressed in Xenopus oocytes
Drug: tolbutamide
Target: ATP-sensitive inward rectifier potassium channel 11 (Ion channel)
Gene: Kcnj11
UniProt: Q61743 (KCJ11_MOUSE)
Organism: Mus musculus
Activity: IC50 = 4.5
Action type: BLOCKER
Drug: tolbutamide
Target: Sulfonylurea receptor 1, Kir6.2 (Ion channel)
Gene: ABCC8|KCNJ11
UniProt: Q09428|Q14654 (ABCC8_HUMAN|KCJ11_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.046
Action type: BLOCKER
Assay: [86]Rb+ efflux in RINm5F insulinoma cells
Drug: tolcapone
Target: Transthyretin (Secreted)
Gene: TTR
UniProt: P02766 (TTHY_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.69
Assay: Binding affinity to transthyretin (unknown origin) by ITC method
Drug: tolcapone
Target: Catechol O-methyltransferase (Enzyme)
Gene: Comt
UniProt: P22734 (COMT_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 8.66
Assay: Inhibition of Catechol O-methyltransferase activity in rat brain
Drug: tolcapone
Target: G-protein coupled receptor 35 (GPCR)
Gene: GPR35
UniProt: Q9HC97 (GPR35_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 5.13
Drug: tolcapone
Target: Krueppel-like factor 10 (Nuclear other)
Gene: KLF10
UniProt: Q13118 (KLF10_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.3
Drug: tolcapone
Target: Bile salt export pump (Transporter)
Gene: Abcb11
UniProt: O70127 (ABCBB_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 4.33
Drug: tolcapone
Target: Catechol O-methyltransferase (Enzyme)
Gene: COMT
UniProt: P21964 (COMT_HUMAN)
Organism: Homo sapiens
Activity: Ki = 9.569
Action type: INHIBITOR
Drug: tolfenamic acid
Target: Prostaglandin G/H synthase 2 (Enzyme)
Gene: PTGS2
UniProt: P35354 (PGH2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 8.3
Drug: tolfenamic acid
Target: Prostaglandin G/H synthase 1 (Enzyme)
Gene: PTGS1
UniProt: P23219 (PGH1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.24
Drug: tolfenamic acid
Target: Transthyretin (Secreted)
Gene: TTR
UniProt: P02766 (TTHY_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.4
Drug: tolfenamic acid
Target: Androgen receptor (Nuclear hormone receptor)
Gene: AR
UniProt: P10275 (ANDR_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.33
Drug: tolfenamic acid
Target: Aldo-keto reductase family 1 member C3 (Enzyme)
Gene: AKR1C3
UniProt: P42330 (AK1C3_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.1
Assay: Inhibition of human AKR1C3 using S-(+)-1,2,3,4-tetrahydro-1-naphthol as substrate
Drug: tolmetin
Target: Prostaglandin G/H synthase 2 (Enzyme)
Gene: PTGS2
UniProt: P35354 (PGH2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.84
Action type: INHIBITOR
Drug: tolmetin
Target: Prostaglandin G/H synthase 1 (Enzyme)
Gene: PTGS1
UniProt: P23219 (PGH1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.27
Action type: INHIBITOR
Drug: tolmetin
Target: Aldose reductase (Enzyme)
Gene: AKR1B1
UniProt: P15121 (ALDR_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.62
Assay: Inhibition of Homo sapiens (human) aldose reductase
Drug: tolmetin
Target: Lactoylglutathione lyase (Enzyme)
Gene: GLO1
UniProt: Q04760 (LGUL_HUMAN)
Organism: Homo sapiens
Activity: Ki = 4.06
Assay: Inhibition of glyoxalase 1
Drug: tolmetin
Target: Interleukin-8 (Cytokine)
Gene: CXCL8
UniProt: P10145 (IL8_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7.05
Assay: Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay
Drug: tolmetin
Target: Aldose reductase (Enzyme)
Gene: Akr1b1
UniProt: P07943 (ALDR_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 5.667
Assay: DRUGMATRIX: Aldose Reductase enzyme inhibition (substrate: DL-Glyceraldehyde)
Drug: tolonium
Target: Microtubule-associated protein tau (Structural)
Gene: MAPT
UniProt: P10636 (TAU_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.16
Assay: Inhibition of recombinant tau (unknown origin) aggregation
Drug: tolonium
Target: Zinc finger protein mex-5 (Cytosolic other)
Gene: mex-5
UniProt: Q9XUB2 (MEX5_CAEEL)
Organism: Caenorhabditis elegans
Activity: EC50 = 4.45
Assay: Active
Drug: toloxatone
Target: Amine oxidase [flavin-containing] B (Enzyme)
Gene: MAOB
UniProt: P27338 (AOFB_HUMAN)
Organism: Homo sapiens
Activity: Ki = 4.82
Assay: Inhibitory concentration for human Monoamine oxidase B
Drug: toloxatone
Target: Amine oxidase [flavin-containing] A (Enzyme)
Gene: Maoa
UniProt: P21396 (AOFA_RAT)
Organism: Rattus norvegicus
Activity: Ki = 6.42
Assay: Inhibitory concentration for rat Monoamine oxidase A
Drug: toloxatone
Target: Amine oxidase [flavin-containing] A (Enzyme)
Gene: MAOA
UniProt: P21398 (AOFA_BOVIN)
Organism: Bos taurus
Activity: Ki = 6.42
Assay: Inhibition of bovine brain mitochondrial Monoamine oxidase A (MAO-A) compared to toloxatone
Drug: toloxatone
Target: Amine oxidase [flavin-containing] B (Enzyme)
Gene: MAOB
UniProt: P56560 (AOFB_BOVIN)
Organism: Bos taurus
Activity: Ki = 4.82
Assay: Inhibition of bovine brain mitochondrial Monoamine oxidase B (MAO-B) compared to toloxatone
Drug: toloxatone
Target: Amine oxidase [flavin-containing] A (Enzyme)
Gene: MAOA
UniProt: P21397 (AOFA_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.82
Action type: INHIBITOR
Assay: Inhibition of MAO-A (unknown origin) by luciferase reporter gene assay
Drug: tolperisone
Target: Sigma non-opioid intracellular receptor 1 (Membrane receptor)
Gene: SIGMAR1
UniProt: Q99720 (SGMR1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.253
Assay: DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol)
Drug: tolperisone
Target: Alpha-2B adrenergic receptor (GPCR)
Gene: ADRA2B
UniProt: P18089 (ADA2B_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.341
Assay: DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug: tolperisone
Target: SMR1-alpha3 (Unclassified)
Gene: VCS-alpha3
UniProt: P70634 (P70634_RAT)
Organism: Rattus norvegicus
Activity: Ki = 5.685
Assay: DRUGMATRIX: Sigma2 radioligand binding (ligand: [3H] Ifenprodil)
Drug: tolperisone
Target: BetaB2-crystallin (Unclassified)
Gene: Crybb2
UniProt: P70635 (P70635_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 5.474
Assay: DRUGMATRIX: Sigma2 radioligand binding (ligand: [3H] Ifenprodil)
Drug: tolrestat
Target: Alcohol dehydrogenase [NADP(+)] (Enzyme)
Gene: AKR1A1
UniProt: P14550 (AK1A1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.14
Assay: Inhibition of N-terminal 6His-tagged human aldehyde reductase expressed in Escherichia coli BL21(DE3) mediated D-glucuronate reduction
Drug: tolrestat
Target: Alcohol dehydrogenase [NADP(+)] (Enzyme)
Gene: AKR1A1
UniProt: P50578 (AK1A1_PIG)
Organism: Sus scrofa
Activity: IC50 = 6.27
Assay: Selectivity ratio measured as the IC50 ratio of aldehyde/aldose reductase values
Drug: tolrestat
Target: Aldose reductase (Enzyme)
Gene: AKR1B1
UniProt: P80276 (ALDR_PIG)
Organism: Sus scrofa
Activity: IC50 = 7.82
Assay: In vitro inhibitory activity against aldose reductase in porcine lens.
Drug: tolrestat
Target: Aldose reductase (Enzyme)
Gene: Akr1b1
UniProt: P07943 (ALDR_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 8.7
Assay: In vitro inhibition of Aldose reductase (AR) from rat lens (RL)
Drug: tolrestat
Target: Aldose reductase (Enzyme)
Gene: AKR1B1
UniProt: P16116 (ALDR_BOVIN)
Organism: Bos taurus
Activity: IC50 = 7.48
Assay: In vitro inhibition of aldose reductase activity in a partially purified bovine lens preparation
Drug: tolrestat
Target: Alcohol dehydrogenase [NADP(+)] (Enzyme)
Gene: Akr1a1
UniProt: P51635 (AK1A1_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 5.92
Assay: Evaluated for inhibition of Aldehyde reductase 1
Drug: tolrestat
Target: Aldo-keto reductase family 1 member C21 (Enzyme)
Gene: Akr1c21
UniProt: Q91WR5 (AK1CL_MOUSE)
Organism: Mus musculus
Activity: Ki = 4.66
Assay: Inhibition of mouse recombinant AKR1C21
Drug: tolrestat
Target: Aldo-keto reductase family 1 member B10 (Enzyme)
Gene: AKR1B10
UniProt: O60218 (AK1BA_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.3
Assay: Inhibition of reductase activity of N-terminal 6His-tagged human AKR1B10 expressed in Escherichia coli BL21(DE3) assessed as pyridine-3-aldehyde reduction
Drug: tolrestat
Target: Aldose reductase (Enzyme)
Gene: AKR1B1
UniProt: P15121 (ALDR_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 8.509
Action type: INHIBITOR
Drug: tolterodine
Target: Potassium voltage-gated channel subfamily H member 2 (Ion channel)
Gene: KCNH2
UniProt: Q12809 (KCNH2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7.77
Assay: Inhibitory concentration against potassium channel HERG
Drug: tolterodine
Target: Muscarinic acetylcholine receptor M1 (GPCR)
Gene: CHRM1
UniProt: P11229 (ACM1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.85
Assay: Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M1 receptor expressed in CHO cells
Drug: tolterodine
Target: Muscarinic acetylcholine receptor M2 (GPCR)
Gene: CHRM2
UniProt: P08172 (ACM2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.57
Action type: ANTAGONIST
Assay: Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells
Drug: tolterodine
Target: Muscarinic acetylcholine receptor M3 (GPCR)
Gene: CHRM3
UniProt: P20309 (ACM3_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.49
Action type: ANTAGONIST
Assay: Binding affinity to human muscarinic M3 receptor
Drug: tolterodine
Target: Muscarinic acetylcholine receptor M4 (GPCR)
Gene: CHRM4
UniProt: P08173 (ACM4_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.51
Assay: Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M4 receptor expressed in CHO cells
Drug: tolterodine
Target: Muscarinic acetylcholine receptor M5 (GPCR)
Gene: CHRM5
UniProt: P08912 (ACM5_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.66
Assay: Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M5 receptor expressed in CHO cells
Drug: tolterodine
Target: Muscarinic acetylcholine receptor M2 (GPCR)
Gene: Chrm2
UniProt: P10980 (ACM2_RAT)
Organism: Rattus norvegicus
Activity: Ki = 8.16
Assay: Affinity for rat Muscarinic acetylcholine receptor M2
Drug: tolterodine
Target: Muscarinic acetylcholine receptor M1 (GPCR)
Gene: Chrm1
UniProt: P08482 (ACM1_RAT)
Organism: Rattus norvegicus
Activity: Ki = 8.85
Assay: Displacement of [3H]NMS from muscarinic receptor M1 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting method
Drug: tolterodine
Target: Muscarinic acetylcholine receptor M3 (GPCR)
Gene: Chrm3
UniProt: P08483 (ACM3_RAT)
Organism: Rattus norvegicus
Activity: Ki = 8.15
Assay: Affinity for rat Muscarinic acetylcholine receptor M3
Drug: tolterodine
Target: Muscarinic acetylcholine receptor M5 (GPCR)
Gene: Chrm5
UniProt: P08911 (ACM5_RAT)
Organism: Rattus norvegicus
Activity: Ki = 8.66
Assay: Displacement of [3H]NMS from muscarinic receptor M5 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting method
Drug: tolterodine
Target: Muscarinic acetylcholine receptor M4 (GPCR)
Gene: Chrm4
UniProt: P08485 (ACM4_RAT)
Organism: Rattus norvegicus
Activity: Ki = 8.51
Assay: Displacement of [3H]NMS from muscarinic receptor M4 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting method
Drug: topiramate
Target: Sodium channel protein type 5 subunit alpha (Ion channel)
Gene: SCN5A
UniProt: Q14524 (SCN5A_HUMAN)
Organism: Homo sapiens
Action type: BLOCKER
Drug: topiramate
Target: Sodium channel protein type 1 subunit alpha (Ion channel)
Gene: SCN1A
UniProt: P35498 (SCN1A_HUMAN)
Organism: Homo sapiens
Action type: BLOCKER
Drug: topiramate
Target: Nuclear receptor subfamily 1 group I member 2 (Nuclear hormone receptor)
Gene: NR1I2
UniProt: O75469 (NR1I2_HUMAN)
Organism: Homo sapiens
Drug: topiramate
Target: Carbonic anhydrase 2 (Enzyme)
Gene: CA2
UniProt: P00918 (CAH2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.3
Action type: INHIBITOR
Assay: Compound was evaluated for inhibition against human carbonic anhydrase II
Drug: topiramate
Target: Carbonic anhydrase 1 (Enzyme)
Gene: CA1
UniProt: P00915 (CAH1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.6
Assay: Compound was evaluated for inhibition against human carbonic anhydrase I
Drug: topiramate
Target: Carbonic anhydrase 4 (Enzyme)
Gene: CA4
UniProt: P22748 (CAH4_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.31
Action type: INHIBITOR
Assay: Inhibitory activity against human carbonic anhydrase IV (hCAIV)
Drug: topiramate
Target: Carbonic anhydrase 9 (Enzyme)
Gene: CA9
UniProt: Q16790 (CAH9_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.24
Assay: Compound was evaluated for inhibition against human carbonic anhydrase IX
Drug: topiramate
Target: Carbonic anhydrase 12 (Enzyme)
Gene: CA12
UniProt: O43570 (CAH12_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.42
Assay: Ki value against human carbonic anhydrase XII (hCA XII)
Drug: topiramate
Target: Carbonic anhydrase 5A, mitochondrial (Enzyme)
Gene: CA5A
UniProt: P35218 (CAH5A_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.6
Assay: Inhibition of human carbonic anhydrase 5A
Drug: topiramate
Target: Carbonic anhydrase 5B, mitochondrial (Enzyme)
Gene: CA5B
UniProt: Q9Y2D0 (CAH5B_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.52
Assay: Inhibitory activity against human recombinant mitochondrial isozyme CA VB
Drug: topiramate
Target: Carbonic anhydrase 7 (Enzyme)
Gene: CA7
UniProt: P43166 (CAH7_HUMAN)
Organism: Homo sapiens
Activity: Ki = 9.06
Assay: Ki value against human carbonic anhydrase VII
Drug: topiramate
Target: Carbonic anhydrase (Enzyme)
Gene: cynT
UniProt: O24855 (CYNT_HELPY)
Organism: Helicobacter pylori (strain ATCC 700392 / 26695)
Activity: Ki = 6.76
Assay: Inhibition of Helicobacter pylori recombinant carbonic anhydrase by stopped-flow CO2 hydrase assay
Drug: topiramate
Target: Carbonic anhydrase 6 (Enzyme)
Gene: CA6
UniProt: P23280 (CAH6_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.35
Assay: Inhibition of full length human recombinant CA VI
Drug: topiramate
Target: Carbonic anhydrase 14 (Enzyme)
Gene: CA14
UniProt: Q9ULX7 (CAH14_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.84
Assay: Inhibitory constant against human carbonic anhydrase XIV in CO2 hydrase assay
Drug: topiramate
Target: Carbonic anhydrase 13 (Enzyme)
Gene: Ca13
UniProt: Q9D6N1 (CAH13_MOUSE)
Organism: Mus musculus
Activity: Ki = 7.33
Assay: Inhibition of murine CA13 by stopped-flow CO2 hydration method
Drug: topiramate
Target: Carbonic anhydrase 4 (Enzyme)
Gene: CA4
UniProt: Q95323 (CAH4_BOVIN)
Organism: Bos taurus
Activity: Ki = 7.27
Assay: Compound was evaluated for inhibition against bovine carbonic anhydrase IV
Drug: topiramate
Target: Sodium channel protein type 2 subunit alpha (Ion channel)
Gene: Scn2a
UniProt: P04775 (SCN2A_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 4.01
Assay: Inhibition of rat Nav1.2 channel expressed in chinese hamster CHL1610 cells at preconditioning pulse of -67 mV after 2 to 3 mins by whole-cell patch-clamp technique
Drug: topiramate
Target: Carbonic anhydrase 2 (Enzyme)
Gene: Ca2
UniProt: P27139 (CAH2_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 5.85
Assay: Inhibition concentration against carbonic anhydrase II in rat determined in esterase assay
Drug: topiramate
Target: Carbonic anhydrase (Enzyme)
UniProt: P40881 (CAH_METTE)
Organism: Methanosarcina thermophila
Activity: Ki = 6.92
Assay: Inhibitory activity against alpha carbonic anhydrase (Co-Cam) from Methanosarcina thermophila
Drug: topiramate
Target: Carbonic anhydrase (Enzyme)
UniProt: Q50565 (Q50565_METTH)
Organism: Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)
Activity: Ki = 4.63
Assay: Inhibitory activity against beta carbonic anhydrase (Cab) from Methanobacterium thermoautotrophicum
Drug: topiramate
Target: Carbonic anhydrase 13 (Enzyme)
Gene: CA13
UniProt: Q8N1Q1 (CAH13_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.33
Assay: Inhibition of human recombinant CA13 by stopped flow CO2 hydrase assay
Drug: topiramate
Target: Carbonic anhydrase 15 (Enzyme)
Gene: Ca15
UniProt: Q99N23 (CAH15_MOUSE)
Organism: Mus musculus
Activity: Ki = 7.11
Assay: Inhibition of mouse recombinant carbonic anhydrase 15 by stopped flow CO2 hydrase assay
Drug: topiramate
Target: Carbonic anhydrase (Enzyme)
Gene: NCE103
UniProt: P53615 (CAN_YEAST)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Activity: Ki = 6.96
Assay: Inhibition of Saccharomyces cerevisiae recombinant CA expressed in Escherichia coli by stopped-flow CO2 hydrase assay
Drug: topiramate
Target: Carbonic anhydrase (Enzyme)
Gene: NCE103
UniProt: Q5AJ71 (CAN_CANAL)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876)
Activity: Ki = 8
Assay: Inhibition of Helicobacter pylori beta-carbonic anhydrase by stopped-flow CO2 hydration assay
Drug: topiramate
Target: Probable transmembrane carbonic anhydrase (Carbonate dehydratase) (Carbonic dehydratase); Transmembrane carbonic anhydrase (Enzyme)
UniProt: P96878 (P96878_MYCTU)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Activity: Ki = 5.52
Assay: Inhibition of Mycobacterium tuberculosis recombinant Rv3273 beta-carbonic anhydrase after 15 mins by stopped flow CO2 hydration assay
Drug: topiramate
Target: Carbonic anhydrase (Enzyme)
UniProt: Q6FTL6 (Q6FTL6_CANGA)
Organism: Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)
Activity: Ki = 6.96
Assay: Inhibition of recombinant full length Candida glabrata NCE103 expressed in Escherichia coli BL21 preincubated for 15 mins by stopped-flow CO2 hydrase assay
Drug: topiramate
Target: Alpha carbonic anhydrase (Enzyme)
Gene: CA
UniProt: B5SU02 (B5SU02_9CNID)
Organism: Stylophora pistillata
Activity: Ki = 7.54
Assay: Inhibition of cloned Stylophora pistillata alpha-CA expressed in human HEK293 cells by stopped-flow CO2 assay
Drug: topiramate
Target: Carbonic anhydrase (Enzyme)
Gene: CA2
UniProt: C0IX24 (C0IX24_9CNID)
Organism: Stylophora pistillata
Activity: Ki = 6.44
Assay: Inhibition of Stylophora pistillata carbonic anhydrase 2 by stopped-flow CO2 hydration assay
Drug: topiramate
Target: Carbonic anhydrase 2 (Enzyme)
Gene: CAN2
UniProt: Q3I4V7 (Q3I4V7_CRYNV)
Organism: Cryptococcus neoformans var. grubii
Activity: Ki = 6.43
Assay: Inhibition of Cryptococcus neoformans recombinant Can2 beta-carbonic anhydrase after 15 mins by stopped flow CO2 hydration assay
Drug: topiramate
Target: Astrosclerin-3 (Enzyme)
UniProt: A6YCJ1 (A6YCJ1_9METZ)
Organism: Astrosclera willeyana
Activity: Ki = 7.42
Assay: Inhibition of GST-tagged astrosclera willeyana Astrosclerin-3 expressed in Escherichia coli after 15 mins preincubation by stopped flow CO2 hydration assay
Drug: topiramate
Target: Beta-carbonic anhydrase 1 (Enzyme)
Gene: mtcA1
UniProt: P9WPJ7 (MTCA1_MYCTU)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Activity: Ki = 6.21
Assay: Inhibition of Mycobacterium tuberculosis recombinant carbonic anhydrase 1 encoded by Rv1284 by stopped flow CO2 hydration assay