AIM-Harvard/TrialPanorama-filtered huggingface dataset:
Drug: quercetin
Target: Beta-lactamase (Enzyme)
Gene: ampC
UniProt: P00811 (AMPC_ECOLI)
Organism: Escherichia coli (strain K12)
Activity: IC50 = 5.4
Assay: Inhibitory activity against Amp C beta-Lactamase
Drug: quercetin
Target: Acetylcholinesterase (Enzyme)
Gene: ACHE
UniProt: P22303 (ACES_HUMAN)
Organism: Homo sapiens
Activity: Ki = 4.42
Assay: Inhibition of human recombinant AChE by Ellman's method
Drug: quercetin
Target: Amine oxidase [flavin-containing] B (Enzyme)
Gene: MAOB
UniProt: P27338 (AOFB_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.05
Assay: Inhibition of human MAOB
Drug: quercetin
Target: Cholinesterase (Enzyme)
Gene: BCHE
UniProt: P06276 (CHLE_HUMAN)
Organism: Homo sapiens
Activity: Ki = 4.17
Assay: Inhibition of human plasma BChE by Ellman's method
Drug: quercetin
Target: Xanthine dehydrogenase/oxidase (Enzyme)
Gene: XDH
UniProt: P47989 (XDH_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.58
Assay: Inhibition of xanthine oxidase assessed as decrease in uric acid production by spectrophotometry
Drug: quercetin
Target: Amine oxidase [flavin-containing] A (Enzyme)
Gene: MAOA
UniProt: P21397 (AOFA_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.55
Assay: Inhibition of human MAOA
Drug: quercetin
Target: Aldose reductase (Enzyme)
Gene: AKR1B1
UniProt: P15121 (ALDR_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7.83
Assay: Inhibition of cataracted human eye lens aldose reductase
Drug: quercetin
Target: Carbonic anhydrase 9 (Enzyme)
Gene: CA9
UniProt: Q16790 (CAH9_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.15
Assay: Inhibition of human CA9 by stopped-flow CO2 hydration assay
Drug: quercetin
Target: Aromatase (Enzyme)
Gene: CYP19A1
UniProt: P11511 (CP19A_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7.92
Assay: Inhibition of human placental microsome CYP19
Drug: quercetin
Target: Carbonic anhydrase 12 (Enzyme)
Gene: CA12
UniProt: O43570 (CAH12_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.03
Assay: Inhibition of human CA12 by stopped-flow CO2 hydration assay
Drug: quercetin
Target: Arachidonate 5-lipoxygenase (Enzyme)
Gene: ALOX5
UniProt: P09917 (LOX5_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.1
Assay: Inhibition of 5LOX in human PBMC by EIA assay
Drug: quercetin
Target: Prothrombin (Enzyme)
Gene: F2
UniProt: P00734 (THRB_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.41
Assay: Inhibition of human thrombin assessed as equilibrium dissociation constant at 50 to 1000 uM by BIAcore analysis
Drug: quercetin
Target: Epidermal growth factor receptor (Kinase)
Gene: EGFR
UniProt: P00533 (EGFR_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.05
Assay: Inhibition of EGFR
Drug: quercetin
Target: Vasopressin V2 receptor (GPCR)
Gene: AVPR2
UniProt: P30518 (V2R_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.2
Assay: Inhibition of vasopressin-stimulated vasopressin V2 receptor in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay
Drug: quercetin
Target: Carbonic anhydrase 5A, mitochondrial (Enzyme)
Gene: CA5A
UniProt: P35218 (CAH5A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.17
Assay: Inhibition of human CA5A by stopped-flow CO2 hydration assay
Drug: quercetin
Target: Carbonic anhydrase 5B, mitochondrial (Enzyme)
Gene: CA5B
UniProt: Q9Y2D0 (CAH5B_HUMAN)
Organism: Homo sapiens
Activity: Ki = 4.92
Assay: Inhibition of human CA5B by stopped-flow CO2 hydration assay
Drug: quercetin
Target: Carbonic anhydrase 7 (Enzyme)
Gene: CA7
UniProt: P43166 (CAH7_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.32
Assay: Inhibition of human CA7 by stopped-flow CO2 hydration assay
Drug: quercetin
Target: Tyrosine-protein phosphatase non-receptor type 1 (Enzyme)
Gene: PTPN1
UniProt: P18031 (PTN1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.63
Assay: The inhibitory activity tested against human Protein-tyrosine phosphatase 1B enzyme
Drug: quercetin
Target: Proto-oncogene tyrosine-protein kinase Src (Kinase)
Gene: SRC
UniProt: P12931 (SRC_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.92
Assay: Inhibition of SRC (unknown origin)
Drug: quercetin
Target: Tyrosine-protein kinase Lck (Kinase)
Gene: LCK
UniProt: P06239 (LCK_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.89
Assay: Ability to inhibit protein-tyrosine kinase activity of p56lck (isolated from bovine thymus) in vitro.
Drug: quercetin
Target: Serine/threonine-protein kinase B-raf (Kinase)
Gene: BRAF
UniProt: P15056 (BRAF_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.12
Assay: Inhibition of B-Raf V600E mutant (unknown origin) using fluorescein-MAP2K1 as substrate after 1 hr by electrophoretic assay
Drug: quercetin
Target: Receptor-type tyrosine-protein kinase FLT3 (Kinase)
Gene: FLT3
UniProt: P36888 (FLT3_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.23
Assay: Inhibition of recombinant FLT3 (unknown origin) by TR-FRET assay
Drug: quercetin
Target: Proto-oncogene tyrosine-protein kinase receptor Ret (Kinase)
Gene: RET
UniProt: P07949 (RET_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.11
Assay: Inhibition of wild type recombinant human RET using peptide as substrate by fluorimetric analysis
Drug: quercetin
Target: Vascular endothelial growth factor receptor 2 (Kinase)
Gene: KDR
UniProt: P35968 (VGFR2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.55
Assay: Inhibition of VEGFR2 (unknown origin)
Drug: quercetin
Target: Dipeptidyl peptidase 4 (Enzyme)
Gene: DPP4
UniProt: P27487 (DPP4_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.49
Assay: Inhibition of human DPP4 using H-Gly-Pro-AMC peptide substrate assessed as increase in fluorescence for 20 mins by fluorimetric assay
Drug: quercetin
Target: Myeloperoxidase (Enzyme)
Gene: MPO
UniProt: P05164 (PERM_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.9
Assay: Inhibition of myeloperoxidase
Drug: quercetin
Target: 72 kDa type IV collagenase (Enzyme)
Gene: MMP2
UniProt: P08253 (MMP2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.18
Assay: Inhibition of human recombinant MMP2 catalytic domain incubated for 20 mins by fluorimetric assay
Drug: quercetin
Target: Cyclin-dependent kinase 1 (Kinase)
Gene: CDK1
UniProt: P06493 (CDK1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.35
Assay: Inhibition of CDK1
Drug: quercetin
Target: Cyclin-dependent kinase 2 (Kinase)
Gene: CDK2
UniProt: P24941 (CDK2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.4
Assay: Inhibition of CDK2
Drug: quercetin
Target: Serine/threonine-protein kinase pim-1 (Kinase)
Gene: PIM1
UniProt: P11309 (PIM1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.6
Assay: Binding affinity to non phosphorylated PIM1
Drug: quercetin
Target: Insulin-like growth factor 1 receptor (Kinase)
Gene: IGF1R
UniProt: P08069 (IGF1R_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.52
Assay: Inhibition of IGF1R (unknown origin)
Drug: quercetin
Target: Lactoylglutathione lyase (Enzyme)
Gene: GLO1
UniProt: Q04760 (LGUL_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.49
Assay: Inhibition of human recombinant His-tagged Glyoxalase 1 expressed in Sf21-Baculovirus system
Drug: quercetin
Target: Alpha-amylase 1 (Enzyme)
Gene: AMY1A
UniProt: P04745 (AMY1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.67
Assay: Inhibition of human salivary alpha-amylase
Drug: quercetin
Target: Neutrophil elastase (Enzyme)
Gene: ELANE
UniProt: P08246 (ELNE_HUMAN)
Organism: Homo sapiens
Activity: Ki = 4.92
Assay: Noncompetitive inhibition of human neutrophil elastase using varying levels of MeOSuc-AAPV-pNA as substrate measured after 30 mins by double-reciprocal Lineweaver-Burk plot analysis
Drug: quercetin
Target: Focal adhesion kinase 1 (Kinase)
Gene: PTK2
UniProt: Q05397 (FAK1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.92
Assay: Inhibition of FAK (unknown origin)
Drug: quercetin
Target: Arachidonate 15-lipoxygenase (Enzyme)
Gene: ALOX15
UniProt: P16050 (LOX15_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.66
Assay: Inhibition of 15-hLO1
Drug: quercetin
Target: Carbonic anhydrase 3 (Enzyme)
Gene: CA3
UniProt: P07451 (CAH3_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.09
Assay: Inhibition of human CA3 by stopped-flow CO2 hydration assay
Drug: quercetin
Target: Stromelysin-1 (Enzyme)
Gene: MMP3
UniProt: P08254 (MMP3_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.25
Assay: Inhibition of human recombinant MMP3 catalytic domain incubated for 20 mins by fluorimetric assay
Drug: quercetin
Target: Serine/threonine-protein kinase PLK1 (Kinase)
Gene: PLK1
UniProt: P53350 (PLK1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.24
Assay: Inhibition of PLK1 (unknown origin)
Drug: quercetin
Target: Carbonic anhydrase 6 (Enzyme)
Gene: CA6
UniProt: P23280 (CAH6_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.21
Assay: Inhibition of human CA6 by stopped-flow CO2 hydration assay
Drug: quercetin
Target: Estradiol 17-beta-dehydrogenase 2 (Enzyme)
Gene: HSD17B2
UniProt: P37059 (DHB2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.81
Assay: Inhibition of human recombinant 17beta-HSD2 expressed in HEK293 cell lysate assessed as conversion of radiolabeled estrone to estradiol
Drug: quercetin
Target: Tyrosine-protein kinase SYK (Kinase)
Gene: SYK
UniProt: P43405 (KSYK_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.7
Drug: quercetin
Target: Prolyl endopeptidase (Enzyme)
Gene: PREP
UniProt: P48147 (PPCE_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.89
Assay: Inhibition of human brain prolyl oligopeptidase expressed in Escherichia coli
Drug: quercetin
Target: Arachidonate 12-lipoxygenase, 12S-type (Enzyme)
Gene: ALOX12
UniProt: P18054 (LOX12_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.36
Assay: Inhibition of 12-hLO
Drug: quercetin
Target: Hepatocyte growth factor receptor (Kinase)
Gene: MET
UniProt: P08581 (MET_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.24
Assay: Inhibition of wild type MET (unknown origin)
Drug: quercetin
Target: Serine/threonine-protein kinase Nek2 (Kinase)
Gene: NEK2
UniProt: P51955 (NEK2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.24
Assay: Inhibition of NEK2 (unknown origin)
Drug: quercetin
Target: Carbonic anhydrase 14 (Enzyme)
Gene: CA14
UniProt: Q9ULX7 (CAH14_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.27
Assay: Inhibition of human CA14 by stopped-flow CO2 hydration assay
Drug: quercetin
Target: Calcium/calmodulin-dependent protein kinase type II subunit beta (Kinase)
Gene: CAMK2B
UniProt: Q13554 (KCC2B_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.52
Assay: Inhibition of CAMK2 using autocamtide-2 as substrate after 30 mins by PKLight assay
Drug: quercetin
Target: Matrix metalloproteinase-9 (Enzyme)
Gene: MMP9
UniProt: P14780 (MMP9_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.79
Assay: Inhibition of human recombinant MMP9 catalytic domain incubated for 20 mins by fluorimetric assay
Drug: quercetin
Target: Serine/threonine-protein kinase N1 (Kinase)
Gene: PKN1
UniProt: Q16512 (PKN1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.24
Assay: Inhibition of PRK1 (unknown origin)
Drug: quercetin
Target: Phospholipase A2 (Enzyme)
Gene: PLA2G1B
UniProt: P04054 (PA21B_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.7
Assay: Inhibition of phospholipase A2
Drug: quercetin
Target: ALK tyrosine kinase receptor (Kinase)
Gene: ALK
UniProt: Q9UM73 (ALK_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.48
Assay: Inhibition of ALK (unknown origin)
Drug: quercetin
Target: RAC-alpha serine/threonine-protein kinase (Kinase)
Gene: AKT1
UniProt: P31749 (AKT1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.27
Assay: Inhibition of AKT1 (unknown origin)
Drug: quercetin
Target: Macrophage metalloelastase (Enzyme)
Gene: MMP12
UniProt: P39900 (MMP12_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.99
Assay: Inhibition of human recombinant MMP12 catalytic domain incubated for 20 mins by fluorimetric assay
Drug: quercetin
Target: Collagenase 3 (Enzyme)
Gene: MMP13
UniProt: P45452 (MMP13_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.07
Assay: Inhibition of human recombinant MMP13 catalytic domain incubated for 20 mins by fluorimetric assay
Drug: quercetin
Target: Chymotrypsinogen B (Enzyme)
Gene: CTRB1
UniProt: P17538 (CTRB1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4
Assay: Inhibitory activity against Chymotrypsinogen from Thermus flavus
Drug: quercetin
Target: Beta-secretase 1 (Enzyme)
Gene: BACE1
UniProt: P56817 (BACE1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 4.85
Assay: Noncompetitive inhibition of human recombinant BACE1 after 60 mins by Dixon plot analysis
Drug: quercetin
Target: Glycogen synthase kinase-3 beta (Kinase)
Gene: GSK3B
UniProt: P49841 (GSK3B_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.7
Assay: Inhibition of Homo sapiens (human) recombinant GSK3beta after 30 min by Kinase-Glo assay
Drug: quercetin
Target: Alcohol dehydrogenase [NADP(+)] (Enzyme)
Gene: AKR1A1
UniProt: P50578 (AK1A1_PIG)
Organism: Sus scrofa
Activity: IC50 = 4.42
Assay: Inhibition of pig ALR1
Drug: quercetin
Target: Aldose reductase (Enzyme)
Gene: AKR1B1
UniProt: P80276 (ALDR_PIG)
Organism: Sus scrofa
Activity: IC50 = 4.3
Assay: Inhibition of pig lens aldose reductase by spectrophotometry
Drug: quercetin
Target: Bifunctional epoxide hydrolase 2 (Enzyme)
Gene: EPHX2
UniProt: P34913 (HYES_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.47
Assay: Inhibition of sEH (unknown origin) assessed as substrate PHOME hydrolysis after 1 hr by fluorescence method
Drug: quercetin
Target: Glycogen phosphorylase, liver form (Enzyme)
Gene: PYGL
UniProt: P06737 (PYGL_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.32
Drug: quercetin
Target: Lysine--tRNA ligase (Enzyme)
Gene: KARS
UniProt: Q15046 (SYK_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.7
Assay: Inhibition of SYK
Drug: quercetin
Target: Cationic trypsin (Enzyme)
UniProt: P00760 (TRY1_BOVIN)
Organism: Bos taurus
Activity: IC50 = 5.15
Assay: Inhibitory concentration of the compounds against Bovine trypsin enzyme.
Drug: quercetin
Target: Xanthine dehydrogenase/oxidase (Enzyme)
Gene: XDH
UniProt: P80457 (XDH_BOVIN)
Organism: Bos taurus
Activity: Ki = 5.92
Assay: Inhibition of bovine xanthine oxidase
Drug: quercetin
Target: Aldose reductase (Enzyme)
Gene: Akr1b1
UniProt: P07943 (ALDR_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 6
Assay: In vitro inhibitory activity against L-Hexonate Dehydrogenase from rat kidney
Drug: quercetin
Target: Arachidonate 15-lipoxygenase (Enzyme)
Gene: ALOX15
UniProt: P12530 (LOX15_RABIT)
Organism: Oryctolagus cuniculus
Activity: IC50 = 6.37
Assay: Inhibition of 15LOX in rabbit reticulocytes by EIA assay
Drug: quercetin
Target: C-C chemokine receptor type 4 (GPCR)
Gene: CCR4
UniProt: P51679 (CCR4_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5
Assay: Inhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay
Drug: quercetin
Target: Integrase (Enzyme)
Gene: pol
UniProt: Q7ZJM1 (Q7ZJM1_9HIV1)
Organism: Human immunodeficiency virus 1
Activity: IC50 = 6.22
Assay: Inhibition of His6-tagged HIV-1 integrase assessed as decrease in integrase-Flag-LEDGF/p75 interaction preincubated with enzyme for 30 mins followed by addition of Flag-LEDGF/p75 for 1 hr by AlphaScreen assay
Drug: quercetin
Target: Carbonic anhydrase 13 (Enzyme)
Gene: Ca13
UniProt: Q9D6N1 (CAH13_MOUSE)
Organism: Mus musculus
Activity: Ki = 5.04
Assay: Inhibition of mouse CA13 by stopped-flow CO2 hydration assay
Drug: quercetin
Target: Aldose reductase (Enzyme)
Gene: AKR1B1
UniProt: P16116 (ALDR_BOVIN)
Organism: Bos taurus
Activity: IC50 = 5.55
Assay: Inhibition of aldose reductase from calf lense by AR assay
Drug: quercetin
Target: Adenosine receptor A1 (GPCR)
Gene: Adora1
UniProt: P25099 (AA1R_RAT)
Organism: Rattus norvegicus
Activity: Ki = 5.61
Assay: Displacement of specific [3H]PIA binding from adenosine A1 receptor in rat brain membranes.
Drug: quercetin
Target: Alcohol dehydrogenase [NADP(+)] (Enzyme)
Gene: Akr1a1
UniProt: P51635 (AK1A1_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 5.63
Assay: In vitro inhibitory activity against aldehyde reductase 1 (ALR1) from rat kidney.
Drug: quercetin
Target: Arachidonate 5-lipoxygenase (Enzyme)
Gene: Alox5
UniProt: P12527 (LOX5_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 6.7
Assay: In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determined
Drug: quercetin
Target: Adenosine receptor A2a (GPCR)
Gene: Adora2a
UniProt: P30543 (AA2AR_RAT)
Organism: Rattus norvegicus
Activity: Ki = 5.16
Assay: Affinity at Adenosine A2A receptor in rat striatal membranes by [3H]- CGS 21680 displacement.
Drug: quercetin
Target: Beta-lactamase (Enzyme)
Gene: ampC
UniProt: P05364 (AMPC_ENTCL)
Organism: Enterobacter cloacae
Activity: IC50 = 4.07
Assay: Inhibition of Enterobacter cloacae beta-lactamase incubated for 10 mins followed by nitrocefin substrate challenge and measured for 5 mins by spectrophotometric analysis
Drug: quercetin
Target: Amine oxidase [flavin-containing] A (Enzyme)
Gene: MAOA
UniProt: P21398 (AOFA_BOVIN)
Organism: Bos taurus
Activity: IC50 = 8
Assay: Inhibition of bovine MAO-A by fluorimetric method
Drug: quercetin
Target: Amine oxidase [flavin-containing] B (Enzyme)
Gene: MAOB
UniProt: P56560 (AOFB_BOVIN)
Organism: Bos taurus
Activity: IC50 = 4.7
Assay: Inhibition of bovine MAO-B by fluorimetric method
Drug: quercetin
Target: Cyclin-dependent kinase 6 (Kinase)
Gene: CDK6
UniProt: Q00534 (CDK6_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.6
Assay: Inhibition of human cyclin-dependent kinase 6 complex with a virus-encoded cyclin from herpesvirus saimiri (Vcyclin)
Drug: quercetin
Target: Enoyl-[acyl-carrier-protein] reductase [NADH] FabI (Enzyme)
Gene: fabI
UniProt: P0AEK4 (FABI_ECOLI)
Organism: Escherichia coli (strain K12)
Activity: IC50 = 4.7
Assay: Inhibition of Escherichia coli ENR
Drug: quercetin
Target: Enoyl-acyl-carrier protein reductase (Enzyme)
Gene: fabI
UniProt: Q965D5 (Q965D5_PLAFA)
Organism: Plasmodium falciparum
Activity: Ki = 7.66
Assay: Inhibition of Plasmodium falciparum ENR in presence of triclosan
Drug: quercetin
Target: Polyphenol oxidase 2 (Enzyme)
Gene: PPO2
UniProt: O42713 (PPO2_AGABI)
Organism: Agaricus bisporus
Activity: IC50 = 4.51
Assay: Inhibition of mushroom tyrosinase
Drug: quercetin
Target: Aldo-keto reductase family 1 member C21 (Enzyme)
Gene: Akr1c21
UniProt: Q91WR5 (AK1CL_MOUSE)
Organism: Mus musculus
Activity: Ki = 4.96
Assay: Inhibition of mouse recombinant AKR1C21
Drug: quercetin
Target: Tyrosine-protein kinase receptor UFO (Kinase)
Gene: AXL
UniProt: P30530 (UFO_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.02
Assay: Inhibition of AXL (unknown origin)
Drug: quercetin
Target: Neuraminidase (Enzyme)
UniProt: B4URF0 (B4URF0_9INFA)
Organism: Influenza A virus (A/WSN/1933(H1N1))
Activity: IC50 = 5.66
Assay: Noncompetitive inhibition of recombinant influenza A virus rvH1N1 A/Bervig_Mission/1/18 neuraminidase
Drug: quercetin
Target: C-X-C chemokine receptor type 1 (GPCR)
Gene: CXCR1
UniProt: P25024 (CXCR1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.35
Assay: Inhibition of CX3CL1-stimulated CX3CR1 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay
Drug: quercetin
Target: Casein kinase II subunit alpha (Kinase)
Gene: CSNK2A1
UniProt: P68400 (CSK21_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.93
Assay: Inhibitory constant against Zea mays CK2alpha
Drug: quercetin
Target: NUAK family SNF1-like kinase 1 (Kinase)
Gene: NUAK1
UniProt: O60285 (NUAK1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.29
Assay: Inhibition of ARK5 (unknown origin)
Drug: quercetin
Target: Aurora kinase B (Kinase)
Gene: AURKB
UniProt: Q96GD4 (AURKB_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.04
Assay: Inhibition of aurora-B (unknown origin)
Drug: quercetin
Target: Death-associated protein kinase 1 (Kinase)
Gene: DAPK1
UniProt: P53355 (DAPK1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.05
Drug: quercetin
Target: Sialidase (Enzyme)
Gene: nanH
UniProt: P10481 (NANH_CLOPF)
Organism: Clostridium perfringens
Activity: IC50 = 5.77
Assay: Inhibition of Clostridium perfringens neuraminidase
Drug: quercetin
Target: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Kinase)
Gene: PIK3CG
UniProt: P48736 (PK3CG_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.86
Drug: quercetin
Target: G-protein coupled receptor 35 (GPCR)
Gene: GPR35
UniProt: Q9HC97 (GPR35_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.81
Assay: Desensitization of GPR35 receptor in human HT-29 cells assessed as inhibition of zaprinast-induced dynamic mass redistribution after 10 mins
Drug: quercetin
Target: Proteasome subunit beta type-5 (Enzyme)
Gene: PSMB5
UniProt: P28074 (PSB5_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.7
Assay: Inhibition of chymotrypsin-like activity of human 26S proteasome in human Jurkat cells assessed as decrease in AMC hydrolysis using Z-Gly-Gly-Leu-AMC as substrate after 24 hrs by fluorescence based method
Drug: quercetin
Target: Cytochrome P450 1B1 (Enzyme)
Gene: CYP1B1
UniProt: Q16678 (CP1B1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7.11
Assay: Inhibition of human CYP1B1 by EROD assay
Drug: quercetin
Target: Malate dehydrogenase (Enzyme)
Gene: mdh
UniProt: P10584 (MDH_THETH)
Organism: Thermus thermophilus
Activity: IC50 = 5.22
Assay: Inhibitory activity against malate dehydrogenase (MDH) from Thermus flavus
Drug: quercetin
Target: 5'-nucleotidase (Enzyme)
Gene: Nt5e
UniProt: P21588 (5NTD_RAT)
Organism: Rattus norvegicus
Activity: Ki = 7.34
Assay: Inhibition of rat ecto-5'-nucleotidase expressed in Sf9 cells by capillary electrophoresis method
Drug: quercetin
Target: 3-oxoacyl-acyl-carrier protein reductase (Enzyme)
Gene: fabG
UniProt: Q965D6 (Q965D6_PLAFA)
Organism: Plasmodium falciparum
Activity: IC50 = 5.27
Assay: Inhibition of FabG
Drug: quercetin
Target: Beta-hydroxyacyl-ACP dehydratase; Fatty acid synthesis protein (Enzyme)
Gene: fabZ
UniProt: Q965D7 (Q965D7_PLAFA)
Organism: Plasmodium falciparum
Activity: IC50 = 5.82
Assay: Inhibition of FabZ
Drug: quercetin
Target: Phosphatidylinositol 3-kinase regulatory subunit alpha (Kinase)
Gene: PIK3R1
UniProt: P27986 (P85A_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.42
Assay: Inhibition of PI3K
Drug: quercetin
Target: NADPH oxidase 4 (Enzyme)
Gene: NOX4
UniProt: Q9NPH5 (NOX4_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.17
Assay: Inhibition of NOX4 expressed in HEK293 FS cells assessed as H2O2 production by H2O2/Tyr/LPO assay
Drug: quercetin
Target: Replicase polyprotein 1ab (Enzyme)
Gene: rep
UniProt: P0C6X7 (R1AB_CVHSA)
Organism: Human SARS coronavirus
Activity: IC50 = 5.09
Assay: Inhibition of SARS coronavirus helicase assessed as duplex-DNA unwinding by FRET based assay
Drug: quercetin
Target: Lactoperoxidase (Enzyme)
Gene: LPO
UniProt: P80025 (PERL_BOVIN)
Organism: Bos taurus
Activity: IC50 = 5.21
Assay: Inhibition of bovine milk LPO assessed as reduction in NaOSCN production in presence of H2O2/NaSCN after 5 mins
Drug: quercetin
Target: Lysine-specific histone demethylase 1A (Enzyme)
Gene: KDM1A
UniProt: O60341 (KDM1A_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.9
Assay: Inhibition of LSD1 (unknown origin) by fluorescence assay
Drug: quercetin
Target: D-alanine--D-alanine ligase (Enzyme)
Gene: ddl
UniProt: Q1CTD3 (DDL_HELPH)
Organism: Helicobacter pylori (strain HPAG1)
Activity: Ki = 5.37
Assay: Competitive inhibition of Helicobacter pylori Ddl using ATP as substrate
Drug: quercetin
Target: Serine/threonine-protein kinase Nek6 (Kinase)
Gene: NEK6
UniProt: Q9HC98 (NEK6_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.37
Assay: Inhibition of NEK6 (unknown origin)
Drug: quercetin
Target: Arginase (Enzyme)
UniProt: O96394 (O96394_LEIAM)
Organism: Leishmania amazonensis
Activity: IC50 = 5.4
Assay: Inhibition of Leishmania amazonensis recombinant arginase expressed in Escherichia coli Rosetta (DE3) pLysS using L-arginine as substrate incubated for 10 mins prior to substrate addition measured after 10 mins by colorimetry
Drug: quercetin
Target: Cyclin-dependent kinase 1/cyclin B1 (Kinase)
Gene: CDK1|CCNB1
UniProt: P06493|P14635 (CDK1_HUMAN|CCNB1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.7
Assay: Inhibition of Cyclin-dependent kinase 1-cyclin B1
Drug: quercetin
Target: Cyclin-dependent kinase 5/CDK5 activator 1 (Kinase)
Gene: CDK5|CDK5R1
UniProt: Q00535|Q15078 (CDK5_HUMAN|CD5R1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.64
Assay: Inhibition of Cyclin-dependent kinase 5-p25nck5a