AIM-Harvard/TrialPanorama-filtered huggingface dataset:
Drug: bortezomib
Target: Lysosomal protective protein (Enzyme)
Gene: CTSA
UniProt: P10619 (PPGB_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.04
Assay: Inhibition of recombinant cathepsin A (unknown origin) using Mca-Arg-Pro-Pro-Gly-Phe-Ser-Ala-Phe-Lys(Dnp)-OH as substrate incubated with enzyme for 5 mins prior to substrate challenge for 2 hrs by spectrofluorometer analysis
Drug: bortezomib
Target: Carbonic anhydrase 13 (Enzyme)
Gene: CA13
UniProt: Q8N1Q1 (CAH13_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.07
Assay: Inhibition of human CA13 by stopped-flow CO2 hydrase assay
Drug: bortezomib
Target: Carbonic anhydrase 15 (Enzyme)
Gene: Ca15
UniProt: Q99N23 (CAH15_MOUSE)
Organism: Mus musculus
Activity: Ki = 5.57
Assay: Inhibition of mouse CA15 by stopped-flow CO2 hydrase assay
Drug: bortezomib
Target: Proteasome subunit beta type-1 (Enzyme)
Gene: PSMB1
UniProt: P20618 (PSB1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7.28
Action type: INHIBITOR
Assay: Reversible inhibition of human erythrocyte derived 20S proteasome subunit beta1 after 30 mins by fluorogenic assay
Drug: bortezomib
Target: Proteasome subunit beta type-2 (Enzyme)
Gene: PSMB2
UniProt: P49721 (PSB2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.23
Action type: INHIBITOR
Assay: Reversible inhibition of human erythrocyte derived 20S proteasome subunit beta2 after 30 mins by fluorogenic assay
Drug: bortezomib
Target: Proteasome subunit beta type-5 (Enzyme)
Gene: PSMB5
UniProt: P28074 (PSB5_HUMAN)
Organism: Homo sapiens
Activity: Ki = 9.26
Action type: INHIBITOR
Assay: Inhibition of 20S proteasome beta5 subunit (unknown origin) assessed as formation of reversible adduct with N-terminal threonine
Drug: bortezomib
Target: Beta-carbonic anhydrase 1 (Enzyme)
Gene: mtcA1
UniProt: P9WPJ7 (MTCA1_MYCTU)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Activity: Ki = 5.14
Assay: Inhibition of Mycobacterium tuberculosis beta-carbonic anhydrase Rv1284 preincubated for 15 mins by stopped-flow CO2 hydration assay
Drug: bortezomib
Target: PH and SEC7 domain-containing protein 1 (Unclassified)
Gene: PSD
UniProt: A5PKW4 (PSD1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.745
Drug: bortezomib
Target: Nuclear factor NF-kappa-B complex (Transcription factor)
Gene: NFKB1|NFKB2|RELA
UniProt: P19838|Q00653|Q04206 (NFKB1_HUMAN|NFKB2_HUMAN|TF65_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 8.01
Assay: Inhibition of NFkappaB in HEK293 cells incubated for 1 hr prior to TNF-alpha challenge measured after 3 hrs by luciferase reporter gene assay relative to control
Drug: bortezomib
Target: Alpha-chymotrypsin (Enzyme)
UniProt: P00766 (CTRA_BOVIN)
Organism: Bos taurus
Activity: Ki = 5.62
Assay: Inhibition of bovine pancreatic alpha-chymotrypsin using Suc-Leu-Leu-Val-Tyr-AMC as substrate by fluorescence assay
Drug: bortezomib
Target: Proteasome subunit beta (Enzyme)
Gene: PF3D7_1011400
UniProt: Q8IJT1 (Q8IJT1_PLAF7)
Organism: Plasmodium falciparum (isolate 3D7)
Activity: IC50 = 7.51
Assay: Parasite growth inhibition assay
Drug: bortezomib
Target: Proteasome subunit beta type-8 (Enzyme)
Gene: Psmb8
UniProt: P28063 (PSB8_MOUSE)
Organism: Mus musculus
Activity: IC50 = 7.78
Assay: Inhibition of chymotrypsin like activity of mouse spleen 20S proteasome beta5i subunit using Suc-Leu-Leu-Val-Tyr-AMC as substrate preincubated for 15 mins followed by substrate addition measured after 2 hrs by fluorescence-based assay
Drug: bortezomib
Target: Proteasome subunit beta type-9 (Enzyme)
Gene: PSMB9
UniProt: P28065 (PSB9_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 8.52
Assay: Inhibition of human peripheral blood derived 20s immunoproteasome beta1 caspase-like activity using Suc-PAL-AMC as substrate preincubated for 15 mins followed by substrate addition and measured after 60 mins by fluorescence assay
Drug: bortezomib
Target: Proteasome subunit beta type-10 (Enzyme)
Gene: PSMB10
UniProt: P40306 (PSB10_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.03
Assay: Inhibition of 20S proteasome beta 2i (unknown origin) after 1 hr by fluorescence based assay
Drug: bosentan
Target: Nuclear receptor subfamily 1 group I member 2 (Nuclear hormone receptor)
Gene: NR1I2
UniProt: O75469 (NR1I2_HUMAN)
Organism: Homo sapiens
Drug: bosentan
Target: Bile salt export pump (Transporter)
Gene: ABCB11
UniProt: O95342 (ABCBB_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.42
Drug: bosentan
Target: Endothelin-1 receptor (GPCR)
Gene: EDNRA
UniProt: P25101 (EDNRA_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.19
Action type: ANTAGONIST
Assay: Ability to displace endothelin ([125I]ET1) from human Endothelin A receptor
Drug: bosentan
Target: Endothelin B receptor (GPCR)
Gene: EDNRB
UniProt: P24530 (EDNRB_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.1
Action type: ANTAGONIST
Assay: Inhibitory activity against human endothelin B receptor expressed in CHO cells
Drug: bosentan
Target: Endothelin-1 receptor (GPCR)
Gene: Ednra
UniProt: P26684 (EDNRA_RAT)
Organism: Rattus norvegicus
Activity: Ki = 8.19
Assay: Binding affinity towards Endothelin A receptor
Drug: bosentan
Target: Endothelin-1 receptor (GPCR)
Gene: EDNRA
UniProt: Q29010 (EDNRA_PIG)
Organism: Sus scrofa
Activity: IC50 = 8.12
Assay: In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.
Drug: bosentan
Target: Bile salt export pump (Transporter)
Gene: Abcb11
UniProt: O70127 (ABCBB_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 4.51
Drug: bosentan
Target: Endothelin B receptor (GPCR)
Gene: Ednrb
UniProt: P21451 (EDNRB_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 7.02
Drug: bretylium
Target: Beta-1 adrenergic receptor (GPCR)
Gene: ADRB1
UniProt: P08588 (ADRB1_HUMAN)
Organism: Homo sapiens
Drug: bretylium
Target: Beta-2 adrenergic receptor (GPCR)
Gene: ADRB2
UniProt: P07550 (ADRB2_HUMAN)
Organism: Homo sapiens
Drug: bretylium
Target: Sodium-dependent noradrenaline transporter (Transporter)
Gene: SLC6A2
UniProt: P23975 (SC6A2_HUMAN)
Organism: Homo sapiens
Action type: SUBSTRATE
Assay: Mechanism of Action; CHEMBL222; SINGLE PROTEIN
Drug: brimonidine
Target: Alpha-2A adrenergic receptor (GPCR)
Gene: ADRA2A
UniProt: P08913 (ADA2A_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 8.387
Action type: AGONIST
Drug: brimonidine
Target: 5-hydroxytryptamine receptor 1A (GPCR)
Gene: HTR1A
UniProt: P08908 (5HT1A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.836
Assay: DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1A radioligand binding (ligand: [3H] 8-OH-DPAT)
Drug: brimonidine
Target: Alpha-1A adrenergic receptor (GPCR)
Gene: ADRA1A
UniProt: P35348 (ADA1A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.55
Drug: brimonidine
Target: Alpha-2B adrenergic receptor (GPCR)
Gene: ADRA2B
UniProt: P18089 (ADA2B_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 7.26
Action type: AGONIST
Drug: brimonidine
Target: Alpha-2C adrenergic receptor (GPCR)
Gene: ADRA2C
UniProt: P18825 (ADA2C_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 8.469
Action type: AGONIST
Drug: brimonidine
Target: Alpha-1D adrenergic receptor (GPCR)
Gene: ADRA1D
UniProt: P25100 (ADA1D_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.073
Assay: DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug: brimonidine
Target: Alpha-1B adrenergic receptor (GPCR)
Gene: ADRA1B
UniProt: P35368 (ADA1B_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.27
Drug: brimonidine
Target: Alpha-2B adrenergic receptor (GPCR)
Gene: Adra2b
UniProt: P19328 (ADA2B_RAT)
Organism: Rattus norvegicus
Activity: Ki = 7.28
Assay: Displacement of rauwolscine from rat Alpha-2B adrenergic receptor expressed in CHO cells
Drug: brimonidine
Target: 5-hydroxytryptamine receptor 1A (GPCR)
Gene: Htr1a
UniProt: P19327 (5HT1A_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 5.59
Drug: brimonidine
Target: Alpha-1A adrenergic receptor (GPCR)
Gene: ADRA1A
UniProt: P18130 (ADA1A_BOVIN)
Organism: Bos taurus
Activity: EC50 = 5.95
Assay: Agonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assay
Drug: brimonidine
Target: Adrenergic receptor alpha-2 (GPCR)
Gene: Adra2b|Adra2c|Adra2a
UniProt: P19328|P22086|P22909 (ADA2B_RAT|ADA2C_RAT|ADA2A_RAT)
Organism: Rattus norvegicus
Activity: Ki = 7.52
Assay: Binding affinity towards alpha-2 adrenergic receptor in rat using [3H]rauwolscine as radioligand
Drug: brimonidine
Target: Adrenergic receptor alpha-1 (GPCR)
Gene: Adra1b|Adra1d|Adra1a
UniProt: P15823|P23944|P43140 (ADA1B_RAT|ADA1D_RAT|ADA1A_RAT)
Organism: Rattus norvegicus
Activity: Ki = 6.13
Assay: Binding affinity against alpha-1 adrenergic receptor in rat using [3H]prazosin as radioligand
Drug: brimonidine
Target: Alpha-1B adrenergic receptor (GPCR)
UniProt: G3HDX1 (G3HDX1_CRIGR)
Organism: Cricetulus griseus
Activity: EC50 = 6.03
Assay: Agonist activity at hamster recombinant alpha-1B receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assay
Drug: brinzolamide
Target: Carbonic anhydrase 2 (Enzyme)
Gene: CA2
UniProt: P00918 (CAH2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 9.9
Action type: INHIBITOR
Assay: Inhibition of human recombinant carbonic anhydrase 2 by dansylamide (DNSA) competition assay
Drug: brinzolamide
Target: Carbonic anhydrase 1 (Enzyme)
Gene: CA1
UniProt: P00915 (CAH1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.52
Assay: Compound was evaluated for binding affinity against human carbonic anhydrase II (hCA -II)
Drug: brinzolamide
Target: Carbonic anhydrase 4 (Enzyme)
Gene: CA4
UniProt: P22748 (CAH4_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.4
Assay: Inhibition of human full length carbonic anhydrase 4 by stopped flow CO2 hydrase assay
Drug: brinzolamide
Target: Carbonic anhydrase 9 (Enzyme)
Gene: CA9
UniProt: Q16790 (CAH9_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.44
Assay: Inhibition of human carbonic anhydrase9 preincubated for 15 mins by stopped-flow CO2 hydration assay
Drug: brinzolamide
Target: Carbonic anhydrase 12 (Enzyme)
Gene: CA12
UniProt: O43570 (CAH12_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.52
Assay: Inhibitory activity against catalytic domain of human carbonic anhydrase XII
Drug: brinzolamide
Target: Carbonic anhydrase 5A, mitochondrial (Enzyme)
Gene: CA5A
UniProt: P35218 (CAH5A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.3
Assay: Inhibitory activity against human recombinant mitochondrial isozyme CA VA
Drug: brinzolamide
Target: Carbonic anhydrase 5B, mitochondrial (Enzyme)
Gene: CA5B
UniProt: Q9Y2D0 (CAH5B_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.52
Assay: Inhibitory activity against human recombinant mitochondrial isozyme CA VB
Drug: brinzolamide
Target: Carbonic anhydrase 7 (Enzyme)
Gene: CA7
UniProt: P43166 (CAH7_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.55
Assay: Ki value against human carbonic anhydrase VII
Drug: brinzolamide
Target: Carbonic anhydrase (Enzyme)
Gene: cynT
UniProt: O24855 (CYNT_HELPY)
Organism: Helicobacter pylori (strain ATCC 700392 / 26695)
Activity: Ki = 6.68
Assay: Inhibition of Helicobacter pylori recombinant carbonic anhydrase by stopped-flow CO2 hydrase assay
Drug: brinzolamide
Target: Carbonic anhydrase 6 (Enzyme)
Gene: CA6
UniProt: P23280 (CAH6_HUMAN)
Organism: Homo sapiens
Activity: Ki = 9.05
Assay: Inhibition of full length human recombinant CA VI
Drug: brinzolamide
Target: Carbonic anhydrase 14 (Enzyme)
Gene: CA14
UniProt: Q9ULX7 (CAH14_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.62
Assay: Inhibitory constant against human carbonic anhydrase XIV in CO2 hydrase assay
Drug: brinzolamide
Target: Carbonic anhydrase 13 (Enzyme)
Gene: Ca13
UniProt: Q9D6N1 (CAH13_MOUSE)
Organism: Mus musculus
Activity: Ki = 8
Assay: Inhibition of mouse full length carbonic anhydrase 13 by stopped flow CO2 hydrase assay
Drug: brinzolamide
Target: Carbonic anhydrase 4 (Enzyme)
Gene: CA4
UniProt: Q95323 (CAH4_BOVIN)
Organism: Bos taurus
Activity: Ki = 7.35
Assay: Inhibitory activity against Carbonic anhydrase IV isolated from bovine lung
Drug: brinzolamide
Target: Carbonic anhydrase 13 (Enzyme)
Gene: CA13
UniProt: Q8N1Q1 (CAH13_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.96
Assay: Inhibition of human carbonic anhydrase13 preincubated for 15 mins by stopped-flow CO2 hydration assay
Drug: brinzolamide
Target: Carbonic anhydrase 15 (Enzyme)
Gene: Ca15
UniProt: Q99N23 (CAH15_MOUSE)
Organism: Mus musculus
Activity: Ki = 7.21
Assay: Inhibition of mouse recombinant carbonic anhydrase 15 by stopped flow CO2 hydrase assay
Drug: brinzolamide
Target: Carbonic anhydrase (Enzyme)
Gene: NCE103
UniProt: P53615 (CAN_YEAST)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Activity: Ki = 6.94
Assay: Inhibition of Saccharomyces cerevisiae recombinant CA expressed in Escherichia coli by stopped-flow CO2 hydrase assay
Drug: brinzolamide
Target: Carbonic anhydrase (Enzyme)
Gene: NCE103
UniProt: Q5AJ71 (CAN_CANAL)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876)
Activity: Ki = 8.52
Assay: Inhibition of Helicobacter pylori beta-carbonic anhydrase by stopped-flow CO2 hydration assay
Drug: brinzolamide
Target: Probable transmembrane carbonic anhydrase (Carbonate dehydratase) (Carbonic dehydratase); Transmembrane carbonic anhydrase (Enzyme)
UniProt: P96878 (P96878_MYCTU)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Activity: Ki = 6.7
Assay: Inhibition of Mycobacterium tuberculosis recombinant carbonic anhydrase Rv3273 by stopped flow CO2 hydration assay
Drug: brinzolamide
Target: Carbonic anhydrase (Enzyme)
UniProt: Q6FTL6 (Q6FTL6_CANGA)
Organism: Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)
Activity: Ki = 5.36
Assay: Inhibition of recombinant full length Candida glabrata NCE103 expressed in Escherichia coli BL21 preincubated for 15 mins by stopped-flow CO2 hydrase assay
Drug: brinzolamide
Target: Alpha carbonic anhydrase (Enzyme)
Gene: CA
UniProt: B5SU02 (B5SU02_9CNID)
Organism: Stylophora pistillata
Activity: Ki = 7.32
Assay: Inhibition of cloned Stylophora pistillata alpha-CA expressed in human HEK293 cells by stopped-flow CO2 assay
Drug: brinzolamide
Target: Carbonic anhydrase (Enzyme)
Gene: CA2
UniProt: C0IX24 (C0IX24_9CNID)
Organism: Stylophora pistillata
Activity: Ki = 6.77
Assay: Inhibition of Stylophora pistillata carbonic anhydrase 2 by stopped-flow CO2 hydration assay
Drug: brinzolamide
Target: Carbonic anhydrase 2 (Enzyme)
Gene: CAN2
UniProt: Q3I4V7 (Q3I4V7_CRYNV)
Organism: Cryptococcus neoformans var. grubii
Activity: Ki = 7.06
Assay: Inhibition of Cryptococcus neoformans Can2 preincubated for 15 mins measured for 10 to 100 sec by stopped-flow method
Drug: brinzolamide
Target: Astrosclerin-3 (Enzyme)
UniProt: A6YCJ1 (A6YCJ1_9METZ)
Organism: Astrosclera willeyana
Activity: Ki = 6.56
Assay: Inhibition of GST-tagged astrosclera willeyana Astrosclerin-3 expressed in Escherichia coli after 15 mins preincubation by stopped flow CO2 hydration assay
Drug: brinzolamide
Target: Beta-carbonic anhydrase 1 (Enzyme)
Gene: mtcA1
UniProt: P9WPJ7 (MTCA1_MYCTU)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Activity: Ki = 6.08
Assay: Inhibition of Mycobacterium tuberculosis recombinant carbonic anhydrase 1 encoded by Rv1284 by stopped flow CO2 hydration assay
Drug: brinzolamide
Target: Delta carbonic anhydrase (Unclassified)
Gene: ca1
UniProt: Q5U9J1 (Q5U9J1_THAWE)
Organism: Thalassiosira weissflogii
Activity: Ki = 6.93
Assay: Inhibition of Thalassiosira weissflogii delta carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration assay
Drug: brinzolamide
Target: Carbonic anhydrase 2 (Enzyme)
Gene: mtcA2
UniProt: P9WPJ9 (MTCA2_MYCTU)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Activity: Ki = 6.9
Assay: Inhibition of full length Mycobacterium tuberculosis H37Rv recombinant carbonic anhydrase 2 encoded by RV3588c by stopped flow CO2 hydration assay
Drug: brinzolamide
Target: Carbonic anhydrase (Enzyme)
UniProt: Q5TU56 (Q5TU56_ANOGA)
Organism: Anopheles gambiae
Activity: Ki = 7.5
Drug: brinzolamide
Target: Carbonic anhydrase, alpha family (Unclassified)
UniProt: Q31FD6 (Q31FD6_HYDCU)
Organism: Hydrogenovibrio crunogenus (strain XCL-2)
Activity: Ki = 8.38
Assay: Inhibition of recombinant Thiomicrospira crunogena XCL-2 carbonic anhydrase by stopped flow CO2 hydrase assay
Drug: brinzolamide
Target: Carbonate dehydratase (Enzyme)
UniProt: B2V8E3 (B2V8E3_SULSY)
Organism: Sulfurihydrogenibium sp. (strain YO3AOP1)
Activity: Ki = 7.91
Assay: Inhibition of recombinant Sulfurihydrogenibium yellowstonense YO3AOP1 carbonic anhydrase by stopped flow CO2 hydrase assay
Drug: brivudine
Target: Thymidine kinase (Kinase)
Gene: TK
UniProt: Q9QNF7 (KITH_HHV1)
Organism: Human herpesvirus 1
Activity: Ki = 6.62
Assay: Inhibition of Herpes simplex virus 1 recombinant thymidine kinase
Drug: brivudine
Target: Thymidine kinase, cytosolic (Kinase)
Gene: TK1
UniProt: P04183 (KITH_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7
Assay: Binding affinity constant against HSV-1 thymidine kinase
Drug: brivudine
Target: Thymidine kinase (Kinase)
Gene: TK
UniProt: P06479 (KITH_HHV1S)
Organism: Human herpesvirus 1 (strain SC16)
Activity: IC50 = 6.52
Assay: Binding affinity towards HSV-1 thymidine kinase
Drug: brivudine
Target: Thymidine kinase (Kinase)
Gene: UL23
UniProt: A3RLP8 (A3RLP8_CHV1)
Organism: Cercopithecine herpesvirus 1
Activity: IC50 = 4.49
Assay: Inhibition of Herpes B virus recombinant thymidine kinase-mediated [3H]TdR phosphorylation
Drug: brodimoprim
Target: Bifunctional dihydrofolate reductase-thymidylate synthase (Enzyme)
UniProt: Q07422 (DRTS_TOXGO)
Organism: Toxoplasma gondii
Activity: IC50 = 7.77
Assay: Inhibition of Toxoplasma gondii Dihydrofolate Reductase
Drug: brodimoprim
Target: Dihydrofolate reductase (Enzyme)
UniProt: P16184 (DYR_PNECA)
Organism: Pneumocystis carinii
Activity: IC50 = 7.51
Assay: Inhibition of Pneumocystis carinii Dihydrofolate Reductase
Drug: brodimoprim
Target: Dihydrofolate reductase (Enzyme)
Gene: Dhfr
UniProt: Q920D2 (DYR_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 7.82
Assay: Inhibition of rat liver Dihydrofolate Reductase
Drug: brodimoprim
Target: Dihydrofolate reductase (Enzyme)
Gene: folA
UniProt: P0ABQ4 (DYR_ECOLI)
Organism: Escherichia coli (strain K12)
Activity: Ki = 8.18
Drug: brodimoprim
Target: Dihydrofolate reductase (Enzyme)
Gene: folA
UniProt: P00381 (DYR_LACCA)
Organism: Lactobacillus casei
Activity: Ki = 7.95
Assay: Inhibition constant of compound against Lactobacillus casei dihydrofolate reductase
Drug: brodimoprim
Target: Dihydrofolate reductase (Enzyme)
Gene: DHFR
UniProt: P00378 (DYR_CHICK)
Organism: Gallus gallus
Activity: Ki = 4.54
Assay: Inhibitory activity against chicken liver dihydrofolate reductase
Drug: brodimoprim
Target: Dihydrofolate reductase (Enzyme)
Gene: dfrA17
UniProt: B0BL08 (B0BL08_ECOLX)
Organism: Escherichia coli
Activity: IC50 = 8.53
Drug: brodimoprim
Target: Dihydrofolate reductase (Enzyme)
Gene: folA
UniProt: Q8Z9J9 (Q8Z9J9_SALTI)
Organism: Salmonella typhi
Activity: Ki = 8.18
Drug: bromazepam
Target: GABA-A receptor alpha-1/beta-2/gamma-2 (Ion channel)
Gene: GABRA1|GABRG2|GABRB2
UniProt: P14867|P18507|P47870 (GBRA1_HUMAN|GBRG2_HUMAN|GBRB2_HUMAN)
Organism: Homo sapiens
Drug: bromfenac
Target: Prostaglandin G/H synthase 2 (Enzyme)
Gene: PTGS2
UniProt: P35354 (PGH2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 8.4
Action type: INHIBITOR
Drug: bromfenac
Target: Prostaglandin G/H synthase 1 (Enzyme)
Gene: PTGS1
UniProt: P23219 (PGH1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 8.29
Action type: INHIBITOR
Drug: bromfenac
Target: Cyclooxygenase (Enzyme)
Gene: PTGS1|PTGS2
UniProt: O62664|O62698 (PGH1_BOVIN|PGH2_BOVIN)
Organism: Bos taurus
Activity: IC50 = 7.1
Assay: Inhibition of prostaglandin G/H synthase obtained from bovine seminal vesicles.
Drug: bromhexine
Target: Sigma non-opioid intracellular receptor 1 (Membrane receptor)
Gene: SIGMAR1
UniProt: Q99720 (SGMR1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.602
Assay: DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol)
Drug: bromhexine
Target: Sodium-dependent serotonin transporter (Transporter)
Gene: SLC6A4
UniProt: P31645 (SC6A4_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.954
Assay: DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine)
Drug: bromhexine
Target: Cytochrome P450 2D6 (Enzyme)
Gene: CYP2D6
UniProt: P10635 (CP2D6_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.708
Assay: DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)
Drug: bromhexine
Target: Membrane-associated progesterone receptor component 1 (Membrane receptor)
Gene: Pgrmc1
UniProt: P70580 (PGRC1_RAT)
Organism: Rattus norvegicus
Activity: Ki = 7.444
Assay: DRUGMATRIX: Sigma2 radioligand binding (ligand: [3H] Ifenprodil)
Drug: bromocriptine
Target: Beta-1 adrenergic receptor (GPCR)
Gene: ADRB1
UniProt: P08588 (ADRB1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.858
Assay: DRUGMATRIX: Adrenergic beta1 radioligand binding (ligand: [125I] Cyanopindolol)
Drug: bromocriptine
Target: Beta-2 adrenergic receptor (GPCR)
Gene: ADRB2
UniProt: P07550 (ADRB2_HUMAN)
Organism: Homo sapiens
Activity: Ki  6.13
Drug: bromocriptine
Target: D(1A) dopamine receptor (GPCR)
Gene: DRD1
UniProt: P21728 (DRD1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.2
Action type: AGONIST
Drug: bromocriptine
Target: D(2) dopamine receptor (GPCR)
Gene: DRD2
UniProt: P14416 (DRD2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 9.7
Action type: AGONIST
Drug: bromocriptine
Target: Alpha-2A adrenergic receptor (GPCR)
Gene: ADRA2A
UniProt: P08913 (ADA2A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8
Drug: bromocriptine
Target: Cytochrome P450 3A4 (Enzyme)
Gene: CYP3A4
UniProt: P08684 (CP3A4_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.699
Assay: DRUGMATRIX: CYP450, 3A4 enzyme inhibition (substrate: 7-Benzyloxy-4-(trifluoromethyl)-coumarin)
Drug: bromocriptine
Target: 5-hydroxytryptamine receptor 1A (GPCR)
Gene: HTR1A
UniProt: P08908 (5HT1A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.9
Drug: bromocriptine
Target: 5-hydroxytryptamine receptor 2A (GPCR)
Gene: HTR2A
UniProt: P28223 (5HT2A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7
Drug: bromocriptine
Target: 5-hydroxytryptamine receptor 2B (GPCR)
Gene: HTR2B
UniProt: P41595 (5HT2B_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.3
Drug: bromocriptine
Target: 5-hydroxytryptamine receptor 2C (GPCR)
Gene: HTR2C
UniProt: P28335 (5HT2C_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.1
Drug: bromocriptine
Target: 5-hydroxytryptamine receptor 6 (GPCR)
Gene: HTR6
UniProt: P50406 (5HT6R_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.5
Action type: AGONIST
Drug: bromocriptine
Target: Alpha-1A adrenergic receptor (GPCR)
Gene: ADRA1A
UniProt: P35348 (ADA1A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.38
Drug: bromocriptine
Target: Alpha-2B adrenergic receptor (GPCR)
Gene: ADRA2B
UniProt: P18089 (ADA2B_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.5
Drug: bromocriptine
Target: D(3) dopamine receptor (GPCR)
Gene: DRD3
UniProt: P35462 (DRD3_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.5
Action type: AGONIST
Drug: bromocriptine
Target: D(1B) dopamine receptor (GPCR)
Gene: DRD5
UniProt: P21918 (DRD5_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.3
Action type: AGONIST
Drug: bromocriptine
Target: 5-hydroxytryptamine receptor 1B (GPCR)
Gene: HTR1B
UniProt: P28222 (5HT1B_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.5
Drug: bromocriptine
Target: 5-hydroxytryptamine receptor 1D (GPCR)
Gene: HTR1D
UniProt: P28221 (5HT1D_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8
Drug: bromocriptine
Target: Alpha-2C adrenergic receptor (GPCR)
Gene: ADRA2C
UniProt: P18825 (ADA2C_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.6
Drug: bromocriptine
Target: D(4) dopamine receptor (GPCR)
Gene: DRD4
UniProt: P21917 (DRD4_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.4
Action type: ANTAGONIST
Drug: bromocriptine
Target: Alpha-1D adrenergic receptor (GPCR)
Gene: ADRA1D
UniProt: P25100 (ADA1D_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.55
Assay: DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug: bromocriptine
Target: Alpha-1B adrenergic receptor (GPCR)
Gene: ADRA1B
UniProt: P35368 (ADA1B_HUMAN)
Organism: Homo sapiens
Activity: Ki  8.86