AIM-Harvard/TrialPanorama-filtered huggingface dataset:
Drug: erlotinib
Target: Serine/threonine-protein kinase ULK3 (Kinase)
Gene: Ulk3
UniProt: Q3U3Q1 (ULK3_MOUSE)
Organism: Mus musculus
Activity: Kd = 6.2
Assay: Average Binding Constant for ULK3 m; NA=Not Active at 10 uM
Drug: erlotinib
Target: Tyrosine-protein kinase receptor UFO (Kinase)
Gene: AXL
UniProt: P30530 (UFO_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.4
Assay: Binding constant for AXL kinase domain
Drug: erlotinib
Target: Tyrosine-protein kinase receptor TYRO3 (Kinase)
Gene: TYRO3
UniProt: Q06418 (TYRO3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.41
Assay: Binding constant for TYRO3 kinase domain
Drug: erlotinib
Target: Non-receptor tyrosine-protein kinase TNK1 (Kinase)
Gene: TNK1
UniProt: Q13470 (TNK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.2
Assay: Binding constant for full-length TNK1
Drug: erlotinib
Target: Non-receptor tyrosine-protein kinase TYK2 (Kinase)
Gene: TYK2
UniProt: P29597 (TYK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.62
Assay: Binding constant for TYK2(JH2domain-pseudokinase) kinase domain
Drug: erlotinib
Target: Proto-oncogene tyrosine-protein kinase Src (Kinase)
Gene: SRC
UniProt: P00523 (SRC_CHICK)
Organism: Gallus gallus
Activity: IC50 = 6
Assay: Inhibition of chicken cSrc single mutant expressed in Escherichia coli
Drug: erlotinib
Target: Casein kinase I isoform delta (Kinase)
Gene: CSNK1D
UniProt: P48730 (KC1D_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.46
Assay: Binding constant for full-length CSNK1D
Drug: erlotinib
Target: Tyrosine-protein kinase receptor Tie-1 (Kinase)
Gene: TIE1
UniProt: P35590 (TIE1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.07
Assay: Binding constant for TIE1 kinase domain
Drug: erlotinib
Target: Tyrosine-protein kinase TXK (Kinase)
Gene: TXK
UniProt: P42681 (TXK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.42
Assay: Binding constant for TXK kinase domain
Drug: erlotinib
Target: MAP kinase-interacting serine/threonine-protein kinase 1 (Kinase)
Gene: MKNK1
UniProt: Q9BUB5 (MKNK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.16
Assay: Binding constant for full-length MKNK1
Drug: erlotinib
Target: Eukaryotic translation initiation factor 2-alpha kinase 4 (Kinase)
Gene: EIF2AK4
UniProt: Q9P2K8 (E2AK4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.36
Assay: Binding constant for GCN2(Kin.Dom.2,S808G) kinase domain
Drug: erlotinib
Target: Serine/threonine-protein kinase SIK2 (Kinase)
Gene: SIK2
UniProt: Q9H0K1 (SIK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.59
Assay: Binding constant for SIK2 kinase domain
Drug: erlotinib
Target: Serine/threonine-protein kinase TNNI3K (Kinase)
Gene: TNNI3K
UniProt: Q59H18 (TNI3K_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.24
Assay: Binding constant for full-length TNNI3K
Drug: erlotinib
Target: Myotonin-protein kinase (Kinase)
Gene: DMPK
UniProt: Q09013 (DMPK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.54
Assay: Binding constant for DMPK kinase domain
Drug: erlotinib
Target: Chaperone activity of bc1 complex-like, mitochondrial (Kinase)
Gene: COQ8A
UniProt: Q8NI60 (COQ8A_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.72
Assay: Binding constant for ADCK3 kinase domain
Drug: erlotinib
Target: Serine/threonine-protein kinase MRCK gamma (Kinase)
Gene: CDC42BPG
UniProt: Q6DT37 (MRCKG_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.47
Assay: Binding constant for DMPK2 kinase domain
Drug: erlotinib
Target: Leukocyte tyrosine kinase receptor (Kinase)
Gene: LTK
UniProt: P29376 (LTK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.05
Assay: Binding constant for LTK kinase domain
Drug: erlotinib
Target: Aurora kinase B (Kinase)
Gene: AURKB
UniProt: Q96GD4 (AURKB_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.85
Assay: Binding constant for AURKB kinase domain
Drug: erlotinib
Target: Tyrosine-protein kinase Blk (Kinase)
Gene: BLK
UniProt: P51451 (BLK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.72
Assay: Binding constant for BLK kinase domain
Drug: erlotinib
Target: Tyrosine-protein kinase Mer (Kinase)
Gene: MERTK
UniProt: Q12866 (MERTK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.01
Assay: Binding constant for MERTK kinase domain
Drug: erlotinib
Target: Citron Rho-interacting kinase (Kinase)
Gene: CIT
UniProt: O14578 (CTRO_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.17
Assay: Binding constant for CIT kinase domain
Drug: erlotinib
Target: AarF domain-containing protein kinase 4 (Kinase)
Gene: COQ8B
UniProt: Q96D53 (COQ8B_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.6
Assay: Binding constant for full-length ADCK4
Drug: erlotinib
Target: Tubulin alpha-1A chain (Structural)
Gene: Tuba1a
UniProt: P68370 (TBA1A_RAT)
Organism: Rattus norvegicus
Activity: Kd = 6.64
Assay: Binding constant for ERBB4 kinase domain
Drug: erlotinib
Target: Mitogen-activated protein kinase 4 (Kinase)
Gene: MAPK4
UniProt: P31152 (MK04_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.6
Assay: Binding constant for ERK4 kinase domain
Drug: erlotinib
Target: Interferon-induced, double-stranded RNA-activated protein kinase (Kinase)
Gene: EIF2AK2
UniProt: P19525 (E2AK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.89
Assay: Binding constant for PRKR kinase domain
Drug: erlotinib
Target: Ribosomal protein S6 kinase alpha-4 (Kinase)
Gene: RPS6KA4
UniProt: O75676 (KS6A4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.15
Assay: Binding constant for RPS6KA4(Kin.Dom.2 - N-terminal) kinase domain
Drug: erlotinib
Target: Misshapen-like kinase 1 (Kinase)
Gene: MINK1
UniProt: Q8N4C8 (MINK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.89
Assay: Binding constant for MINK kinase domain
Drug: erlotinib
Target: Serine/threonine-protein kinase TBK1 (Kinase)
Gene: TBK1
UniProt: Q9UHD2 (TBK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.51
Assay: Binding constant for TBK1 kinase domain
Drug: erlotinib
Target: Dual specificity tyrosine-phosphorylation-regulated kinase 2 (Kinase)
Gene: DYRK2
UniProt: Q92630 (DYRK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.89
Assay: Binding constant for DYRK2 kinase domain
Drug: erlotinib
Target: Ephrin type-B receptor 6 (Kinase)
Gene: EPHB6
UniProt: O15197 (EPHB6_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.77
Assay: Binding constant for EPHB6 kinase domain
Drug: erlotinib
Target: G protein-coupled receptor kinase 4 (Kinase)
Gene: GRK4
UniProt: P32298 (GRK4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.14
Assay: Binding constant for GRK4 kinase domain
Drug: erlotinib
Target: Homeodomain-interacting protein kinase 4 (Kinase)
Gene: HIPK4
UniProt: Q8NE63 (HIPK4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.02
Assay: Binding constant for HIPK4 kinase domain
Drug: erlotinib
Target: Mitogen-activated protein kinase kinase kinase 2 (Kinase)
Gene: MAP3K2
UniProt: Q9Y2U5 (M3K2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.6
Assay: Binding constant for MAP3K2 kinase domain
Drug: erlotinib
Target: Mitogen-activated protein kinase kinase kinase 3 (Kinase)
Gene: MAP3K3
UniProt: Q99759 (M3K3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.64
Assay: Binding constant for MAP3K3 kinase domain
Drug: erlotinib
Target: SRSF protein kinase 3 (Kinase)
Gene: SRPK3
UniProt: Q9UPE1 (SRPK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.08
Assay: Binding constant for SRPK3 kinase domain
Drug: erlotinib
Target: Serine/threonine-protein kinase ULK3 (Kinase)
Gene: ULK3
UniProt: Q6PHR2 (ULK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.04
Assay: Binding constant for ULK3 kinase domain
Drug: erlotinib
Target: Mitogen-activated protein kinase kinase kinase 19 (Kinase)
Gene: MAP3K19
UniProt: Q56UN5 (M3K19_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.6
Assay: Binding constant for YSK4 kinase domain
Drug: erlotinib
Target: Receptor-interacting serine/threonine-protein kinase 4 (Kinase)
Gene: RIPK4
UniProt: P57078 (RIPK4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.31
Assay: Binding constant for RIPK4 kinase domain
Drug: erlotinib
Target: Receptor tyrosine-protein kinase erbB-3 (Kinase)
Gene: ERBB3
UniProt: P21860 (ERBB3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.96
Assay: Binding constant for ERBB3 kinase domain
Drug: erlotinib
Target: Serine/threonine-protein kinase SBK1 (Kinase)
Gene: SBK1
UniProt: Q52WX2 (SBK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.92
Assay: Binding constant for SBK1 kinase domain
Drug: erlotinib
Target: Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (Kinase)
Gene: PIP4K2C
UniProt: Q8TBX8 (PI42C_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6
Assay: Binding constant for PIP5K2C kinase domain
Drug: erlotinib
Target: Dual specificity mitogen-activated protein kinase kinase 5 (Kinase)
Gene: MAP2K5
UniProt: Q13163 (MP2K5_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.02
Assay: Binding constant for MEK5 kinase domain
Drug: erlotinib
Target: Leucine-rich repeat serine/threonine-protein kinase 2 (Kinase)
Gene: LRRK2
UniProt: Q5S007 (LRRK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.54
Assay: Binding constant for LRRK2 kinase domain
Drug: erlotinib
Target: Solute carrier organic anion transporter family member 2B1 (Transporter)
Gene: SLCO2B1
UniProt: O94956 (SO2B1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.28
Action type: INHIBITOR
Drug: erlotinib
Target: Serine/threonine-protein kinase B-raf (Kinase)
Gene: Braf
UniProt: P28028 (BRAF_MOUSE)
Organism: Mus musculus
Activity: IC50 = 7.4
Assay: Inhibition of mouse full length GST-tagged BRAF V600E mutant using recombinant human His6-tagged MEK1 as substrate preincubated for 1 hr followed by substrate addition measured after 25 mins by ELISA
Drug: ertapenem
Target: Penicillin-binding protein 2 (Enzyme)
Gene: pbpA
UniProt: Q9X6V3 (Q9X6V3_PSEAI)
Organism: Pseudomonas aeruginosa
Drug: ertapenem
Target: Penicillin-binding protein 4 (Enzyme)
UniProt: Q5D1E9 (Q5D1E9_STAAU)
Organism: Staphylococcus aureus
Drug: ertapenem
Target: D-ala-D-ala-carboxypeptidase; D-alanyl-D-alanine carboxypeptidase; D-alanyl-D-alanine carboxypeptidase family protein; Penicillin-binding protein 5 (Enzyme)
Gene: dacA
UniProt: Q9X6V7 (Q9X6V7_PSEAI)
Organism: Pseudomonas aeruginosa
Drug: ertapenem
Target: Penicillin-binding protein 1 (Enzyme)
Gene: ponA
UniProt: A1KS91 (A1KS91_NEIMF)
Organism: Neisseria meningitidis serogroup C / serotype 2a (strain ATCC 700532 / DSM 15464 / FAM18)
Drug: ertapenem
Target: D-alanyl-D-alanine carboxypeptidase; D-alanyl-D-alanine carboxypeptidase penicillin-binding protein 6 (Enzyme)
Gene: dacC
UniProt: Q7CHG0 (Q7CHG0_YERPE)
Organism: Yersinia pestis
Drug: ertapenem
Target: D-alanyl-D-alanine carboxypeptidase DacB (Enzyme)
Gene: dacB
UniProt: P24228 (DACB_ECOLI)
Organism: Escherichia coli (strain K12)
Action type: INHIBITOR
Drug: ertapenem
Target: Penicillin-binding protein 1A (Enzyme)
Gene: mrcA
UniProt: P02918 (PBPA_ECOLI)
Organism: Escherichia coli (strain K12)
Action type: INHIBITOR
Drug: ertapenem
Target: Penicillin-binding protein 1B (Enzyme)
Gene: mrcB
UniProt: P02919 (PBPB_ECOLI)
Organism: Escherichia coli (strain K12)
Action type: INHIBITOR
Drug: erythromycin
Target: Potassium voltage-gated channel subfamily H member 2 (Ion channel)
Gene: KCNH2
UniProt: Q12809 (KCNH2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7.41
Assay: Inhibition of human ERG expressed in HEK cells
Drug: erythromycin
Target: Aldehyde oxidase (Enzyme)
Gene: AOX1
UniProt: Q06278 (AOXA_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.824
Drug: erythromycin
Target: Bile salt export pump (Transporter)
Gene: ABCB11
UniProt: O95342 (ABCBB_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.39
Drug: erythromycin
Target: Motilin receptor (GPCR)
Gene: MLNR
UniProt: O43193 (MTLR_HUMAN)
Organism: Homo sapiens
Activity: Ki = 4.43
Assay: In vitro binding affinity towards human motilin receptor
Drug: erythromycin
Target: Cytochrome P450 1B1 (Enzyme)
Gene: CYP1B1
UniProt: Q16678 (CP1B1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.4
Assay: Inhibition of CYP1B1 (unknown origin) expressed in Escherichia coli DH5alpha coexpressing human NADPH-P450 reductase using 7-Ethoxyresorufin as substrate up to 6 mins in presence of NADP+ by spectrofluorometric analysis
Drug: erythromycin propionate
Target: Bile salt export pump (Transporter)
Gene: ABCB11
UniProt: O95342 (ABCBB_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.39
Drug: erythromycin propionate
Target: Bile salt export pump (Transporter)
Gene: Abcb11
UniProt: O70127 (ABCBB_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 4.94
Drug: escitalopram
Target: Sodium-dependent serotonin transporter (Transporter)
Gene: SLC6A4
UniProt: P31645 (SC6A4_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.959
Action type: INHIBITOR
Drug: escitalopram
Target: Sodium-dependent noradrenaline transporter (Transporter)
Gene: SLC6A2
UniProt: P23975 (SC6A2_HUMAN)
Organism: Homo sapiens
Activity: Ki  5.186
Drug: escitalopram
Target: 5-hydroxytryptamine receptor 2C (GPCR)
Gene: HTR2C
UniProt: P28335 (5HT2C_HUMAN)
Organism: Homo sapiens
Activity: Ki  5.597
Drug: escitalopram
Target: Alpha-1A adrenergic receptor (GPCR)
Gene: ADRA1A
UniProt: P35348 (ADA1A_HUMAN)
Organism: Homo sapiens
Activity: Ki  5.412
Drug: escitalopram
Target: Histamine H1 receptor (GPCR)
Gene: HRH1
UniProt: P35367 (HRH1_HUMAN)
Organism: Homo sapiens
Activity: Ki  5.706
Drug: escitalopram
Target: Muscarinic acetylcholine receptor M1 (GPCR)
Gene: CHRM1
UniProt: P11229 (ACM1_HUMAN)
Organism: Homo sapiens
Activity: Ki  5.906
Drug: escitalopram
Target: Sodium-dependent serotonin transporter (Transporter)
Gene: Slc6a4
UniProt: P31652 (SC6A4_RAT)
Organism: Rattus norvegicus
Activity: Ki = 9.05
Assay: Displacement of [3H]citalopram from SERT in rat brain stem by scintillation counting
Drug: escitalopram
Target: Sodium-dependent dopamine transporter (Transporter)
Gene: Slc6a3
UniProt: P23977 (SC6A3_RAT)
Organism: Rattus norvegicus
Activity: Ki = 5.09
Assay: Displacement of [3H]WIN-35428 from DAT in rat caudate-putamen by scintillation counting
Drug: escitalopram
Target: Transporter (Transporter)
Gene: NET
UniProt: Q63380 (Q63380_RAT)
Organism: Rattus norvegicus
Activity: Ki = 4.98
Assay: Displacement of [3H]nisoxetine from NET in rat frontal cortex by scintillation counting
Drug: esmolol
Target: Beta-1 adrenergic receptor (GPCR)
Gene: ADRB1
UniProt: P08588 (ADRB1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.9
Action type: ANTAGONIST
Drug: esmolol
Target: Beta-2 adrenergic receptor (GPCR)
Gene: Adrb2
UniProt: Q8K4Z4 (ADRB2_CAVPO)
Organism: Cavia porcellus
Activity: Kd = 5.2
Assay: Ability to block Beta-2 adrenergic receptor in guinea pig trachea preparation
Drug: esmolol
Target: Beta-1 adrenergic receptor (GPCR)
Gene: ADRB1
UniProt: B0FL73 (B0FL73_CAVPO)
Organism: Cavia porcellus
Activity: Kd = 7
Assay: Ability to block Beta-1 adrenergic receptor in guinea pig right atria preparation
Drug: esomeprazole
Target: Potassium-transporting ATPase (Transporter)
Gene: ATP4A|ATP4B
UniProt: P20648|P51164 (ATP4A_HUMAN|ATP4B_HUMAN)
Organism: Homo sapiens
Action type: INHIBITOR
Assay: Mechanism of Action; CHEMBL2095173; PROTEIN COMPLEX
Drug: estazolam
Target: GABA-A receptor alpha-1/beta-2/gamma-2 (Ion channel)
Gene: GABRA1|GABRG2|GABRB2
UniProt: P14867|P18507|P47870 (GBRA1_HUMAN|GBRG2_HUMAN|GBRB2_HUMAN)
Organism: Homo sapiens
Action type: POSITIVE ALLOSTERIC MODULATOR
Drug: estazolam
Target: GABA-A receptor alpha-2/beta-3/gamma-2 (Ion channel)
Gene: GABRG2|GABRB3|GABRA2
UniProt: P18507|P28472|P47869 (GBRG2_HUMAN|GBRB3_HUMAN|GBRA2_HUMAN)
Organism: Homo sapiens
Action type: POSITIVE ALLOSTERIC MODULATOR
Drug: estazolam
Target: GABA-A receptor alpha-3/beta-3/gamma-2 (Ion channel)
Gene: GABRG2|GABRB3|GABRA3
UniProt: P18507|P28472|P34903 (GBRG2_HUMAN|GBRB3_HUMAN|GBRA3_HUMAN)
Organism: Homo sapiens
Action type: POSITIVE ALLOSTERIC MODULATOR
Drug: estazolam
Target: GABA-A receptor alpha-5/beta-3/gamma-2 (Ion channel)
Gene: GABRG2|GABRB3|GABRA5
UniProt: P18507|P28472|P31644 (GBRG2_HUMAN|GBRB3_HUMAN|GBRA5_HUMAN)
Organism: Homo sapiens
Action type: POSITIVE ALLOSTERIC MODULATOR
Drug: estradiol
Target: Sodium-dependent serotonin transporter (Transporter)
Gene: SLC6A4
UniProt: P31645 (SC6A4_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.243
Assay: DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine)
Drug: estradiol
Target: Aldehyde oxidase (Enzyme)
Gene: AOX1
UniProt: Q06278 (AOXA_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.538
Drug: estradiol
Target: Glucocorticoid receptor (Nuclear hormone receptor)
Gene: NR3C1
UniProt: P04150 (GCR_HUMAN)
Organism: Homo sapiens
Activity: Ki = 4.725
Assay: DRUGMATRIX: Glucocorticoid radioligand binding (ligand: [3H] Dexamethasone)
Drug: estradiol
Target: Sodium-dependent dopamine transporter (Transporter)
Gene: SLC6A3
UniProt: Q01959 (SC6A3_HUMAN)
Organism: Homo sapiens
Activity: Ki = 4.926
Assay: DRUGMATRIX: Dopamine Transporter radioligand binding (ligand: [125I] RTI-55)
Drug: estradiol
Target: Estrogen receptor (Nuclear hormone receptor)
Gene: ESR1
UniProt: P03372 (ESR1_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 10.3
Action type: AGONIST
Drug: estradiol
Target: Androgen receptor (Nuclear hormone receptor)
Gene: AR
UniProt: P10275 (ANDR_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7.72
Assay: Inhibitory activity against AR
Drug: estradiol
Target: Calcium-activated potassium channel subunit alpha-1 (Ion channel)
Gene: KCNMA1
UniProt: Q12791 (KCMA1_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 5.6
Action type: ACTIVATOR
Drug: estradiol
Target: Estrogen receptor beta (Nuclear hormone receptor)
Gene: ESR2
UniProt: Q92731 (ESR2_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 9.7
Drug: estradiol
Target: G-protein coupled estrogen receptor 1 (GPCR)
Gene: GPER1
UniProt: Q99527 (GPER1_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 9.52
Drug: estradiol
Target: Corticosteroid-binding globulin (Secreted)
Gene: SERPINA6
UniProt: P08185 (CBG_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5
Drug: estradiol
Target: Steryl-sulfatase (Enzyme)
Gene: STS
UniProt: P08842 (STS_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.08
Assay: Inhibition of steroid sulfatase activity of JEG-3 cells
Drug: estradiol
Target: Sex hormone-binding globulin (Secreted)
Gene: SHBG
UniProt: P04278 (SHBG_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.83
Assay: Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulin
Drug: estradiol
Target: Steroid hormone receptor ERR1 (Nuclear hormone receptor)
Gene: ESRRA
UniProt: P11474 (ERR1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 8.44
Assay: Inhibition of human ERalpha
Drug: estradiol
Target: Steroid hormone receptor ERR2 (Nuclear hormone receptor)
Gene: ESRRB
UniProt: O95718 (ERR2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 8.49
Assay: Inhibition of human ERbeta
Drug: estradiol
Target: Androgen receptor (Transcription factor)
Gene: Ar
UniProt: P15207 (ANDR_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 6.39
Assay: Inhibitory concentration against recombinant rat androgen receptor expressed in Escherichia coli using [3H]methyltrienolone (R 1881)
Drug: estradiol
Target: Arachidonate 15-lipoxygenase (Enzyme)
Gene: ALOX15
UniProt: P12530 (LOX15_RABIT)
Organism: Oryctolagus cuniculus
Activity: IC50 = 4.947
Assay: DRUGMATRIX: Lipoxygenase 15-LO enzyme inhibition (substrate: Linoleic acid)
Drug: estradiol
Target: Progesterone receptor (Transcription factor)
Gene: PGR
UniProt: Q690N0 (Q690N0_BOVIN)
Organism: Bos taurus
Activity: Ki = 5.372
Assay: DRUGMATRIX: Progesterone radioligand binding (ligand: [3H] R-5020)
Drug: estradiol
Target: Estrogen receptor (Transcription factor)
Gene: Esr1
UniProt: P06211 (ESR1_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 8.72
Assay: Inhibition of [3H]17-beta-estradiol binding to rat ER alpha expressed in Escherichia coli
Drug: estradiol
Target: Estrogen receptor beta (Transcription factor)
Gene: Esr2
UniProt: Q62986 (ESR2_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 8.77
Assay: Inhibition of [3H]17-beta-estradiol binding to rat ER beta expressed in Escherichia coli
Drug: estradiol
Target: Estrogen receptor beta (Transcription factor)
Gene: Esr2
UniProt: O08537 (ESR2_MOUSE)
Organism: Mus musculus
Activity: IC50 = 8.64
Assay: Inhibition of [3H]17-beta-estradiol binding to mouse ER beta expressed in Escherichia coli
Drug: estradiol
Target: Estrogen receptor (Transcription factor)
Gene: Esr1
UniProt: P19785 (ESR1_MOUSE)
Organism: Mus musculus
Activity: IC50 = 8.66
Assay: Inhibition of [3H]17-beta-estradiol binding to mouse ER alpha expressed in Escherichia coli
Drug: estradiol
Target: Cytochrome P450 1B1 (Enzyme)
Gene: CYP1B1
UniProt: Q16678 (CP1B1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.72
Assay: Inhibition of human CYP1B1 expressed in supersomes using ethoxyresorufin as substrate after 20 mins in presence of NADP by Dixon plot analysis
Drug: estradiol
Target: Estrogen receptor (Transcription factor)
Gene: Esr1|Esr2
UniProt: P06211|Q62986 (ESR1_RAT|ESR2_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 9.45
Assay: Inhibition of estradiol binding to estrogen receptor
Drug: estradiol benzoate
Target: Sodium-dependent serotonin transporter (Transporter)
Gene: SLC6A4
UniProt: P31645 (SC6A4_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.71
Assay: DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine)
Drug: estradiol benzoate
Target: Sodium-dependent noradrenaline transporter (Transporter)
Gene: SLC6A2
UniProt: P23975 (SC6A2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 4.767
Assay: DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55)
Drug: estradiol benzoate
Target: 5-hydroxytryptamine receptor 2B (GPCR)
Gene: HTR2B
UniProt: P41595 (5HT2B_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.133
Assay: DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
Drug: estradiol benzoate
Target: Glucocorticoid receptor (Nuclear hormone receptor)
Gene: NR3C1
UniProt: P04150 (GCR_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.637
Assay: DRUGMATRIX: Glucocorticoid radioligand binding (ligand: [3H] Dexamethasone)
Drug: estradiol benzoate
Target: Alpha-2C adrenergic receptor (GPCR)
Gene: ADRA2C
UniProt: P18825 (ADA2C_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.446
Assay: DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
Drug: estradiol benzoate
Target: Adenosine receptor A3 (GPCR)
Gene: ADORA3
UniProt: P0DMS8 (AA3R_HUMAN)
Organism: Homo sapiens
Activity: Ki = 4.91
Assay: DRUGMATRIX: Adenosine A3 radioligand binding (ligand: AB-MECA)
Drug: estradiol benzoate
Target: Estrogen receptor (Nuclear hormone receptor)
Gene: ESR1
UniProt: P03372 (ESR1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.745
Assay: DRUGMATRIX: Estrogen ERalpha radioligand binding (ligand: [3H] Estradiol)
Drug: estradiol benzoate
Target: Sex hormone-binding globulin (Secreted)
Gene: SHBG
UniProt: P04278 (SHBG_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.94
Assay: Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulin
Drug: estradiol benzoate
Target: Tyrosine-protein kinase Fyn (Kinase)
Gene: FYN
UniProt: P06241 (FYN_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.638
Assay: DRUGMATRIX: Protein Tyrosine Kinase, Fyn enzyme inhibition (substrate: Poly(Glu:Tyr))
Drug: estradiol benzoate
Target: Androgen receptor (Transcription factor)
Gene: Ar
UniProt: P15207 (ANDR_RAT)
Organism: Rattus norvegicus
Activity: Ki = 8.156
Assay: DRUGMATRIX: Androgen (Testosterone) AR radioligand binding (ligand: [3H] Mibolerone)
Drug: estradiol benzoate
Target: Progesterone receptor (Transcription factor)
Gene: PGR
UniProt: Q690N0 (Q690N0_BOVIN)
Organism: Bos taurus
Activity: Ki = 5.902
Assay: DRUGMATRIX: Progesterone radioligand binding (ligand: [3H] R-5020)
Drug: estradiol cypionate
Target: Estrogen receptor (Nuclear hormone receptor)
Gene: ESR1
UniProt: P03372 (ESR1_HUMAN)
Organism: Homo sapiens
Action type: AGONIST
Assay: Mechanism of Action; CHEMBL206; SINGLE PROTEIN
Drug: estradiol mustard
Target: Estrogen receptor (Transcription factor)
Gene: Esr1
UniProt: P06211 (ESR1_RAT)
Organism: Rattus norvegicus
Activity: Kd = 5.52
Assay: Displacement of radiolabeled estradiol from estradiol receptor in rat uterine cytosol
Drug: estradiol valerate
Target: Estrogen receptor (Nuclear hormone receptor)
Gene: ESR1
UniProt: P03372 (ESR1_HUMAN)
Organism: Homo sapiens
Action type: AGONIST
Assay: Mechanism of Action; CHEMBL206; SINGLE PROTEIN