AIM-Harvard/TrialPanorama-filtered huggingface dataset:
Drug: ruboxistaurin
Target: Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (Kinase)
Gene: PIP5K1A
UniProt: Q99755 (PI51A_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.16
Assay: Binding constant for full-length PIP5K1A
Drug: ruboxistaurin
Target: Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (Kinase)
Gene: PIP4K2B
UniProt: P78356 (PI42B_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.08
Assay: Binding constant for full-length PIP5K2B
Drug: ruboxistaurin
Target: Serine/threonine-protein kinase RIO1 (Kinase)
Gene: RIOK1
UniProt: Q9BRS2 (RIOK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.09
Assay: Binding constant for full-length RIOK1
Drug: ruboxistaurin
Target: Serine/threonine-protein kinase tousled-like 1 (Kinase)
Gene: TLK1
UniProt: Q9UKI8 (TLK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.68
Assay: Binding constant for TLK1 kinase domain
Drug: ruboxistaurin
Target: Casein kinase II subunit alpha (Kinase)
Gene: CSNK2A1
UniProt: P68400 (CSK21_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.44
Assay: Binding constant for full-length CSNK2A1
Drug: ruboxistaurin
Target: Casein kinase II subunit alpha' (Kinase)
Gene: CSNK2A2
UniProt: P19784 (CSK22_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.47
Assay: Binding constant for full-length CSNK2A2
Drug: ruboxistaurin
Target: Dual specificity tyrosine-phosphorylation-regulated kinase 1B (Kinase)
Gene: DYRK1B
UniProt: Q9Y463 (DYR1B_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.27
Assay: Binding constant for full-length DYRK1B
Drug: ruboxistaurin
Target: Serine/threonine-protein kinase STK11 (Kinase)
Gene: STK11
UniProt: Q15831 (STK11_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.23
Assay: Binding constant for LKB1 kinase domain
Drug: ruboxistaurin
Target: MAP kinase-interacting serine/threonine-protein kinase 1 (Kinase)
Gene: MKNK1
UniProt: Q9BUB5 (MKNK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.15
Assay: Binding constant for MKNK1 kinase domain
Drug: ruboxistaurin
Target: Serine/threonine-protein kinase RIO3 (Kinase)
Gene: RIOK3
UniProt: O14730 (RIOK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.19
Assay: Binding constant for RIOK3 kinase domain
Drug: ruboxistaurin
Target: SRSF protein kinase 1 (Kinase)
Gene: SRPK1
UniProt: Q96SB4 (SRPK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.92
Assay: Binding constant for SRPK1 kinase domain
Drug: ruboxistaurin
Target: SRSF protein kinase 2 (Kinase)
Gene: SRPK2
UniProt: P78362 (SRPK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.96
Assay: Binding constant for SRPK2 kinase domain
Drug: ruboxistaurin
Target: Serine/threonine-protein kinase 33 (Kinase)
Gene: STK33
UniProt: Q9BYT3 (STK33_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.59
Assay: Binding constant for STK33 kinase domain
Drug: ruboxistaurin
Target: Myotonin-protein kinase (Kinase)
Gene: DMPK
UniProt: Q09013 (DMPK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.55
Assay: Binding constant for DMPK kinase domain
Drug: ruboxistaurin
Target: RAC-gamma serine/threonine-protein kinase (Kinase)
Gene: AKT3
UniProt: Q9Y243 (AKT3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.85
Assay: Binding constant for AKT3 kinase domain
Drug: ruboxistaurin
Target: Serine/threonine-protein kinase LATS1 (Kinase)
Gene: LATS1
UniProt: O95835 (LATS1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.59
Assay: Binding constant for LATS1 kinase domain
Drug: ruboxistaurin
Target: Serine/threonine-protein kinase LATS2 (Kinase)
Gene: LATS2
UniProt: Q9NRM7 (LATS2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.19
Assay: Binding constant for LATS2 kinase domain
Drug: ruboxistaurin
Target: Mitogen-activated protein kinase kinase kinase kinase 1 (Kinase)
Gene: MAP4K1
UniProt: Q92918 (M4K1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.59
Assay: Binding constant for MAP4K1 kinase domain
Drug: ruboxistaurin
Target: NUAK family SNF1-like kinase 1 (Kinase)
Gene: NUAK1
UniProt: O60285 (NUAK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.74
Assay: Binding constant for ARK5 kinase domain
Drug: ruboxistaurin
Target: Serine/threonine-protein kinase pim-3 (Kinase)
Gene: PIM3
UniProt: Q86V86 (PIM3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.92
Assay: Binding constant for PIM3 kinase domain
Drug: ruboxistaurin
Target: cAMP-dependent protein kinase catalytic subunit alpha (Kinase)
Gene: PRKACA
UniProt: P17612 (KAPCA_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.27
Assay: Binding constant for PKAC-alpha kinase domain
Drug: ruboxistaurin
Target: Mitogen-activated protein kinase kinase kinase kinase 3 (Kinase)
Gene: MAP4K3
UniProt: Q8IVH8 (M4K3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.08
Assay: Binding constant for MAP4K3 kinase domain
Drug: ruboxistaurin
Target: Dual specificity mitogen-activated protein kinase kinase 4 (Kinase)
Gene: MAP2K4
UniProt: P45985 (MP2K4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.03
Assay: Binding constant for MEK4 kinase domain
Drug: ruboxistaurin
Target: Dual specificity mitogen-activated protein kinase kinase 6 (Kinase)
Gene: MAP2K6
UniProt: P52564 (MP2K6_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.41
Assay: Binding constant for MEK6 kinase domain
Drug: ruboxistaurin
Target: Mitogen-activated protein kinase kinase kinase 9 (Kinase)
Gene: MAP3K9
UniProt: P80192 (M3K9_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.85
Assay: Binding constant for MLK1 kinase domain
Drug: ruboxistaurin
Target: Citron Rho-interacting kinase (Kinase)
Gene: CIT
UniProt: O14578 (CTRO_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.85
Assay: Binding constant for CIT kinase domain
Drug: ruboxistaurin
Target: Death-associated protein kinase 1 (Kinase)
Gene: DAPK1
UniProt: P53355 (DAPK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.01
Assay: Binding constant for DAPK1 kinase domain
Drug: ruboxistaurin
Target: Mitogen-activated protein kinase 15 (Kinase)
Gene: MAPK15
UniProt: Q8TD08 (MK15_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.06
Assay: Binding constant for ERK8 kinase domain
Drug: ruboxistaurin
Target: Serine/threonine-protein kinase D2 (Kinase)
Gene: PRKD2
UniProt: Q9BZL6 (KPCD2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.05
Assay: Binding constant for PRKD2 kinase domain
Drug: ruboxistaurin
Target: cGMP-dependent protein kinase 2 (Kinase)
Gene: PRKG2
UniProt: Q13237 (KGP2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.51
Assay: Binding constant for PRKG2 kinase domain
Drug: ruboxistaurin
Target: Proto-oncogene tyrosine-protein kinase ROS (Kinase)
Gene: ROS1
UniProt: P08922 (ROS1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.24
Assay: Binding constant for ROS1 kinase domain
Drug: ruboxistaurin
Target: Ribosomal protein S6 kinase alpha-1 (Kinase)
Gene: RPS6KA1
UniProt: Q15418 (KS6A1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.4
Assay: Binding constant for RPS6KA1(Kin.Dom.1 - N-terminal) kinase domain
Drug: ruboxistaurin
Target: Ribosomal protein S6 kinase alpha-4 (Kinase)
Gene: RPS6KA4
UniProt: O75676 (KS6A4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.21
Assay: Binding constant for RPS6KA4(Kin.Dom.1 - C-terminal) kinase domain
Drug: ruboxistaurin
Target: Mitogen-activated protein kinase kinase kinase kinase 2 (Kinase)
Gene: MAP4K2
UniProt: Q12851 (M4K2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.54
Assay: Binding constant for MAP4K2 kinase domain
Drug: ruboxistaurin
Target: Misshapen-like kinase 1 (Kinase)
Gene: MINK1
UniProt: Q8N4C8 (MINK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.51
Assay: Binding constant for MINK kinase domain
Drug: ruboxistaurin
Target: Serine/threonine-protein kinase TBK1 (Kinase)
Gene: TBK1
UniProt: Q9UHD2 (TBK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.01
Assay: Binding constant for TBK1 kinase domain
Drug: ruboxistaurin
Target: Cyclin-dependent kinase 4 (Kinase)
Gene: CDK4
UniProt: P11802 (CDK4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.55
Assay: Binding constant for CDK4-cyclinD1 kinase domain
Drug: ruboxistaurin
Target: Serine/threonine-protein kinase Chk2 (Kinase)
Gene: CHEK2
UniProt: O96017 (CHK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.43
Assay: Binding constant for CHEK2 kinase domain
Drug: ruboxistaurin
Target: Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Kinase)
Gene: DYRK1A
UniProt: Q13627 (DYR1A_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.6
Assay: Binding constant for DYRK1A kinase domain
Drug: ruboxistaurin
Target: Rhodopsin kinase (Kinase)
Gene: GRK1
UniProt: Q15835 (RK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.1
Assay: Binding constant for GRK1 kinase domain
Drug: ruboxistaurin
Target: G protein-coupled receptor kinase 4 (Kinase)
Gene: GRK4
UniProt: P32298 (GRK4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.23
Assay: Binding constant for GRK4 kinase domain
Drug: ruboxistaurin
Target: G protein-coupled receptor kinase 7 (Kinase)
Gene: GRK7
UniProt: Q8WTQ7 (GRK7_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.51
Assay: Binding constant for GRK7 kinase domain
Drug: ruboxistaurin
Target: Homeodomain-interacting protein kinase 2 (Kinase)
Gene: HIPK2
UniProt: Q9H2X6 (HIPK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.85
Assay: Binding constant for HIPK2 kinase domain
Drug: ruboxistaurin
Target: Homeodomain-interacting protein kinase 3 (Kinase)
Gene: HIPK3
UniProt: Q9H422 (HIPK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.11
Assay: Binding constant for HIPK3 kinase domain
Drug: ruboxistaurin
Target: Serine/threonine-protein kinase ICK (Kinase)
Gene: ICK
UniProt: Q9UPZ9 (ICK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.62
Assay: Binding constant for ICK kinase domain
Drug: ruboxistaurin
Target: Mitogen-activated protein kinase kinase kinase 2 (Kinase)
Gene: MAP3K2
UniProt: Q9Y2U5 (M3K2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.15
Assay: Binding constant for MAP3K2 kinase domain
Drug: ruboxistaurin
Target: Mitogen-activated protein kinase kinase kinase 3 (Kinase)
Gene: MAP3K3
UniProt: Q99759 (M3K3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.77
Assay: Binding constant for MAP3K3 kinase domain
Drug: ruboxistaurin
Target: SRSF protein kinase 3 (Kinase)
Gene: SRPK3
UniProt: Q9UPE1 (SRPK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.8
Assay: Binding constant for SRPK3 kinase domain
Drug: ruboxistaurin
Target: Serine/threonine-protein kinase TAO1 (Kinase)
Gene: TAOK1
UniProt: Q7L7X3 (TAOK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.74
Assay: Binding constant for TAOK1 kinase domain
Drug: ruboxistaurin
Target: Serine/threonine-protein kinase TAO3 (Kinase)
Gene: TAOK3
UniProt: Q9H2K8 (TAOK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.01
Assay: Binding constant for TAOK3 kinase domain
Drug: ruboxistaurin
Target: Mitogen-activated protein kinase kinase kinase 19 (Kinase)
Gene: MAP3K19
UniProt: Q56UN5 (M3K19_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.32
Assay: Binding constant for YSK4 kinase domain
Drug: ruboxistaurin
Target: Homeodomain-interacting protein kinase 1 (Kinase)
Gene: HIPK1
UniProt: Q86Z02 (HIPK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.64
Assay: Binding constant for HIPK1 kinase domain
Drug: ruboxistaurin
Target: Cyclin-dependent kinase-like 5 (Kinase)
Gene: CDKL5
UniProt: O76039 (CDKL5_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.39
Assay: Binding constant for CDKL5 kinase domain
Drug: ruboxistaurin
Target: Protein kinase C iota type (Kinase)
Gene: PRKCI
UniProt: P41743 (KPCI_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.85
Assay: Binding constant for PRKCI kinase domain
Drug: ruboxistaurin
Target: Serine/threonine-protein kinase PRP4 homolog (Kinase)
Gene: PRPF4B
UniProt: Q13523 (PRP4B_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.8
Assay: Binding constant for PRP4 kinase domain
Drug: ruboxistaurin
Target: Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma (Kinase)
Gene: PIP5K1C
UniProt: O60331 (PI51C_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.29
Assay: Binding constant for PIP5K1C kinase domain
Drug: ruboxistaurin
Target: Serine/threonine-protein kinase Sgk3 (Kinase)
Gene: SGK3
UniProt: Q96BR1 (SGK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.85
Assay: Binding constant for SGK3 kinase domain
Drug: ruboxistaurin
Target: Serine/threonine-protein kinase TAO2 (Kinase)
Gene: TAOK2
UniProt: Q9UL54 (TAOK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.41
Assay: Binding constant for TAOK2 kinase domain
Drug: ruboxistaurin
Target: Dual specificity mitogen-activated protein kinase kinase 5 (Kinase)
Gene: MAP2K5
UniProt: Q13163 (MP2K5_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.96
Assay: Binding constant for MEK5 kinase domain
Drug: ruboxistaurin
Target: Leucine-rich repeat serine/threonine-protein kinase 2 (Kinase)
Gene: LRRK2
UniProt: Q5S007 (LRRK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.01
Assay: Binding constant for LRRK2(G2019S) kinase domain
Drug: ruboxistaurin
Target: Protein kinase C (PKC) (Kinase)
Gene: Prkca|Prkcd|Prkce|Prkcz|Prkcg|Prkcb|Prkch|Prkcq
UniProt: P05696|P09215|P09216|P09217|P63319|P68403|Q64617|Q9WTQ0 (KPCA_RAT|KPCD_RAT|KPCE_RAT|KPCZ_RAT|KPCG_RAT|KPCB_RAT|KPCL_RAT|KPCT_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 6.49
Assay: Inhibition of purified rat brain protein kinase C (RB-PKC)
Drug: ruboxistaurin
Target: CaM kinase II (Kinase)
Gene: CAMK2B|CAMK2G|CAMK2D|CAMK2A
UniProt: Q13554|Q13555|Q13557|Q9UQM7 (KCC2B_HUMAN|KCC2G_HUMAN|KCC2D_HUMAN|KCC2A_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.21
Assay: Inhibition of purified mammalian brain [Ca(2+)]/Calmodulin dependent kinase
Drug: rufinamide
Target: Carbonic anhydrase 5A, mitochondrial (Enzyme)
Gene: CA5A
UniProt: P35218 (CAH5A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.46
Assay: Inhibition of recombinant human carbonic anhydrase VA preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydration assay
Drug: rufinamide
Target: Sodium channel alpha subunit (Ion channel)
Gene: SCN1A|SCN4A|SCN7A|SCN5A|SCN9A|SCN2A|SCN3A|SCN11A|SCN8A|SCN10A
UniProt: P35498|P35499|Q01118|Q14524|Q15858|Q99250|Q9NY46|Q9UI33|Q9UQD0|Q9Y5Y9 (SCN1A_HUMAN|SCN4A_HUMAN|SCN7A_HUMAN|SCN5A_HUMAN|SCN9A_HUMAN|SCN2A_HUMAN|SCN3A_HUMAN|SCNBA_HUMAN|SCN8A_HUMAN|SCNAA_HUMAN)
Organism: Homo sapiens
Action type: BLOCKER
Assay: Mechanism of Action; CHEMBL2331043; PROTEIN FAMILY
Drug: rutoside
Target: Alpha-2A adrenergic receptor (GPCR)
Gene: ADRA2A
UniProt: P08913 (ADA2A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.03
Assay: Binding affinity to adrenergic alpha2A receptor
Drug: rutoside
Target: Muscarinic acetylcholine receptor M5 (GPCR)
Gene: CHRM5
UniProt: P08912 (ACM5_HUMAN)
Organism: Homo sapiens
Activity: Ki  7.454
Drug: rutoside
Target: Alpha-2C adrenergic receptor (GPCR)
Gene: ADRA2C
UniProt: P18825 (ADA2C_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.02
Assay: Binding affinity to adrenergic alpha2c receptor
Drug: rutoside
Target: Acetylcholinesterase (Enzyme)
Gene: ACHE
UniProt: P22303 (ACES_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7.92
Assay: Inhibition of AChE (unknown origin)
Drug: rutoside
Target: Xanthine dehydrogenase/oxidase (Enzyme)
Gene: XDH
UniProt: P47989 (XDH_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.28
Assay: Inhibition of xanthine oxidase assessed as decrease in uric acid production by spectrophotometry
Drug: rutoside
Target: Bifunctional epoxide hydrolase 2 (Enzyme)
Gene: EPHX2
UniProt: P34913 (HYES_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.61
Assay: Inhibition of sEH (unknown origin) assessed as substrate PHOME hydrolysis after 1 hr by fluorescence method
Drug: rutoside
Target: Aldose reductase (Enzyme)
Gene: Akr1b1
UniProt: P07943 (ALDR_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 4.89
Assay: Inhibition of aldose reductase in rat lens homogenates by fluorophotometer
Drug: rutoside
Target: Polyphenol oxidase 2 (Enzyme)
Gene: PPO2
UniProt: O42713 (PPO2_AGABI)
Organism: Agaricus bisporus
Activity: IC50 = 4.16
Assay: Inhibition of mushroom tyrosinase using L-DOPA as substrate measured at 1 min interval by spectrophotometric method
Drug: rutoside
Target: Serum albumin (Secreted)
Gene: ALB
UniProt: P02769 (ALBU_BOVIN)
Organism: Bos taurus
Activity: IC50 = 4.38
Assay: Inhibition of glycation of bovine serum albumin assessed as advanced glycated end product measured after 7 days by spectrofluorimeter in presence of glucose anhydrous
Drug: rutoside
Target: Neuraminidase (Enzyme)
UniProt: B4URF0 (B4URF0_9INFA)
Organism: Influenza A virus (A/WSN/1933(H1N1))
Activity: Ki = 4.47
Assay: Noncompetitive inhibition of recombinant influenza A virus rvH1N1 A/Bervig_Mission/1/18 neuraminidase
Drug: rutoside
Target: Sialidase (Enzyme)
Gene: nanH
UniProt: P10481 (NANH_CLOPF)
Organism: Clostridium perfringens
Activity: IC50 = 4.51
Assay: Inhibition of Clostridium perfringens neuraminidase
Drug: rutoside
Target: Lysine-specific histone demethylase 1A (Enzyme)
Gene: KDM1A
UniProt: O60341 (KDM1A_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.67
Assay: Inhibition of LSD1 (unknown origin) by fluorescence assay
Drug: rutoside
Target: Neuromedin-U receptor 2 (GPCR)
Gene: NMUR2
UniProt: Q9GZQ4 (NMUR2_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 5.92
Drug: rutoside
Target: Neuraminidase (Enzyme)
UniProt: P03469 (NRAM_I77AB)
Organism: Influenza A virus (strain A/USSR/90/1977 H1N1)
Activity: IC50 = 4.02
Drug: sabcomeline
Target: Muscarinic acetylcholine receptor M1 (GPCR)
Gene: CHRM1
UniProt: P11229 (ACM1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.77
Assay: In vitro affinity against human Muscarinic acetylcholine receptor M1 using quinuclidynyl benzylate (QNB)
Drug: sabcomeline
Target: Muscarinic acetylcholine receptor M2 (GPCR)
Gene: CHRM2
UniProt: P08172 (ACM2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.74
Assay: In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2
Drug: sabcomeline
Target: Muscarinic acetylcholine receptor M3 (GPCR)
Gene: CHRM3
UniProt: P20309 (ACM3_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7.22
Assay: In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M3
Drug: sabcomeline
Target: Muscarinic acetylcholine receptor M4 (GPCR)
Gene: CHRM4
UniProt: P08173 (ACM4_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 8.24
Assay: Partial agonist activity at human M4 receptor co-expressed with Galpha16 in CHO cells assessed as calcium mobilization after 60 mins by FLIPR assay
Drug: sabcomeline
Target: Muscarinic acetylcholine receptor M5 (GPCR)
Gene: CHRM5
UniProt: P08912 (ACM5_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.1
Action type: AGONIST
Drug: sabcomeline
Target: Muscarinic acetylcholine receptor (GPCR)
Gene: Chrm1|Chrm3|Chrm4|Chrm5|Chrm2
UniProt: P08482|P08483|P08485|P08911|P10980 (ACM1_RAT|ACM3_RAT|ACM4_RAT|ACM5_RAT|ACM2_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 7.85
Assay: In vitro affinity evaluated using [3H]- oxotremorine as radioligand in rat cerebral cortex for muscarinic acetylcholine receptor
Drug: saralasin
Target: Type-1 angiotensin II receptor (GPCR)
Gene: AGTR1
UniProt: P30556 (AGTR1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 9.77
Action type: ANTAGONIST
Assay: Binding affinity to human AT1 receptor by radioligand displacement assay
Drug: saralasin
Target: Type-2 angiotensin II receptor (GPCR)
Gene: AGTR2
UniProt: P50052 (AGTR2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 9.82
Assay: Displacement of radiolabeled saralasin from human AT2 receptor
Drug: saralasin
Target: Type-1B angiotensin II receptor (GPCR)
Gene: Agtr1b
UniProt: P29089 (AGTRB_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 8.62
Assay: Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
Drug: saralasin
Target: Type-2 angiotensin II receptor (GPCR)
Gene: Agtr2
UniProt: P35351 (AGTR2_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 9
Action type: ANTAGONIST
Drug: saralasin
Target: Angiotensin II receptor (AT-1) type-1 (GPCR)
Gene: Agtr1|Agtr1b
UniProt: P25095|P29089 (AGTRA_RAT|AGTRB_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 8.77
Assay: In vitro binding affinity to the angiotensin II receptor, type 1 in rat liver
Drug: sitaxentan
Target: Endothelin-1 receptor (GPCR)
Gene: EDNRA
UniProt: P25101 (EDNRA_HUMAN)
Organism: Homo sapiens
Activity: Ki = 9.37
Action type: ANTAGONIST
Assay: Binding affinity against human Endothelin A receptor
Drug: sitaxentan
Target: Endothelin B receptor (GPCR)
Gene: EDNRB
UniProt: P24530 (EDNRB_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.01
Action type: ANTAGONIST
Assay: In vitro inhibition of endothelin binding to human Endothelin B receptor using [125I]-labeled ET-1 competition assay
Drug: sitaxentan
Target: Endothelin-1 receptor (GPCR)
Gene: Ednra
UniProt: P26684 (EDNRA_RAT)
Organism: Rattus norvegicus
Activity: Ki = 9.37
Action type: ANTAGONIST
Assay: Binding affinity towards Endothelin A receptor
Drug: stallimycin
Target: DNA topoisomerase 1 (Enzyme)
Gene: TOP1
UniProt: P11387 (TOP1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.57
Assay: Inhibit supercoil relaxation property of topoisomerase I.
Drug: stallimycin
Target: GTPase HRas (Cytosolic other)
Gene: HRAS
UniProt: P01112 (RASH_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.7
Assay: Tested for 50% inhibition of generation of Human Ha-ras polymerase chain reaction(PCR) products
Drug: stallimycin
Target: Estrogen receptor (Nuclear hormone receptor)
Gene: ESR1|ESR2
UniProt: P03372|Q92731 (ESR1_HUMAN|ESR2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7.7
Assay: Tested for 50% inhibition of generation of Human estrogen receptor polymerase chain reaction(PCR) products
Drug: sulbentine
Target: Mu-type opioid receptor (GPCR)
Gene: Oprm1
UniProt: P33535 (OPRM_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 4.55
Assay: In vitro inhibition of [3H]DAMGO (Tyr-D-Ala-Gly-(Me)-Phe-Gly-ol) binding to Opioid receptor mu 1 using rat brain membranes
Drug: sulbentine
Target: Delta-type opioid receptor (GPCR)
Gene: Oprd1
UniProt: P33533 (OPRD_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 4.54
Assay: In vitro inhibition of [3H]- [p-Cl-Phe4]DPDPE binding to Opioid receptor delta 1 using rat brain membranes.
Drug: sulmazole
Target: cGMP-specific 3',5'-cyclic phosphodiesterase (Enzyme)
Gene: PDE5A
UniProt: O76074 (PDE5A_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.68
Assay: In vitro inhibition of PDE-V isolated from porcine pulmonary artery.
Drug: sulmazole
Target: Phosphodiesterase 3 (Enzyme)
Gene: PDE3B|PDE3A
UniProt: Q13370|Q14432 (PDE3B_HUMAN|PDE3A_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.3
Assay: Concentration of compound required for 50% inhibition of type III cAMP phosphodiesterase from dog ventricles, activity expressed as pIC50
Drug: oxedrine
Target: 5-hydroxytryptamine receptor 1A (GPCR)
Gene: HTR1A
UniProt: P08908 (5HT1A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 4.2
Assay: Displacement of [3H]8-OH-DPAT from 5HT1A receptor by vacuum filtration
Drug: oxedrine
Target: Neuromedin-U receptor 2 (GPCR)
Gene: NMUR2
UniProt: Q9GZQ4 (NMUR2_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 5.18
Drug: talastine
Target: Histamine H1 receptor (GPCR)
Gene: HRH1
UniProt: P35367 (HRH1_HUMAN)
Organism: Homo sapiens
Action type: ANTAGONIST
Assay: Mechanism of Action
Drug: tamibarotene
Target: Retinoic acid receptor alpha (Nuclear hormone receptor)
Gene: RARA
UniProt: P10276 (RARA_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7.11
Assay: Binding affinity for Retinoic Acid Receptor alpha (RAR alpha)
Drug: tamibarotene
Target: Retinoic acid receptor beta (Nuclear hormone receptor)
Gene: RARB
UniProt: P10826 (RARB_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 6.63
Action type: AGONIST
Drug: tamibarotene
Target: Retinoic acid receptor gamma (Nuclear hormone receptor)
Gene: RARG
UniProt: P13631 (RARG_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 6.23
Action type: AGONIST
Drug: terazosin
Target: Alpha-2A adrenergic receptor (GPCR)
Gene: ADRA2A
UniProt: P08913 (ADA2A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.26
Drug: terazosin
Target: Potassium voltage-gated channel subfamily H member 2 (Ion channel)
Gene: KCNH2
UniProt: Q12809 (KCNH2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.75
Assay: Inhibition of human ERG
Drug: terazosin
Target: 5-hydroxytryptamine receptor 2A (GPCR)
Gene: HTR2A
UniProt: P28223 (5HT2A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.45
Drug: terazosin
Target: Alpha-1A adrenergic receptor (GPCR)
Gene: ADRA1A
UniProt: P35348 (ADA1A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.95
Action type: ANTAGONIST