AIM-Harvard/TrialPanorama-filtered huggingface dataset:
Drug: nintedanib
Target: Non-receptor tyrosine-protein kinase TYK2 (Kinase)
Gene: TYK2
UniProt: P29597 (TYK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.43
Assay: Binding constant for TYK2(JH1domain-catalytic) kinase domain
Drug: nintedanib
Target: Serine/threonine-protein kinase Chk1 (Kinase)
Gene: CHEK1
UniProt: O14757 (CHK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.54
Assay: Binding constant for CHEK1 kinase domain
Drug: nintedanib
Target: Serine/threonine-protein kinase PAK 3 (Kinase)
Gene: PAK3
UniProt: O75914 (PAK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.68
Assay: Binding constant for PAK3 kinase domain
Drug: nintedanib
Target: Cyclin-dependent kinase 17 (Kinase)
Gene: CDK17
UniProt: Q00537 (CDK17_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.03
Assay: Binding constant for PCTK2 kinase domain
Drug: nintedanib
Target: Cyclin-dependent kinase 18 (Kinase)
Gene: CDK18
UniProt: Q07002 (CDK18_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.29
Assay: Binding constant for PCTK3 kinase domain
Drug: nintedanib
Target: Cyclin-dependent kinase 14 (Kinase)
Gene: CDK14
UniProt: O94921 (CDK14_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.33
Assay: Binding constant for PFTK1 kinase domain
Drug: nintedanib
Target: Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (Kinase)
Gene: PIP5K1A
UniProt: Q99755 (PI51A_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.31
Assay: Binding constant for PIP5K1A kinase domain
Drug: nintedanib
Target: Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (Kinase)
Gene: PIP4K2B
UniProt: P78356 (PI42B_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.77
Assay: Binding constant for PIP5K2B kinase domain
Drug: nintedanib
Target: Myosin light chain kinase family member 4 (Kinase)
Gene: MYLK4
UniProt: Q86YV6 (MYLK4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.36
Assay: Binding constant for MYLK4 kinase domain
Drug: nintedanib
Target: Wee1-like protein kinase (Kinase)
Gene: WEE1
UniProt: P30291 (WEE1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.54
Assay: Binding constant for WEE1 kinase domain
Drug: nintedanib
Target: Protein-tyrosine kinase 2-beta (Kinase)
Gene: PTK2B
UniProt: Q14289 (FAK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.09
Assay: Binding constant for PYK2 kinase domain
Drug: nintedanib
Target: Serine/threonine-protein kinase RIO1 (Kinase)
Gene: RIOK1
UniProt: Q9BRS2 (RIOK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.64
Assay: Binding constant for RIOK1 kinase domain
Drug: nintedanib
Target: Casein kinase I isoform delta (Kinase)
Gene: CSNK1D
UniProt: P48730 (KC1D_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.89
Assay: Binding constant for CSNK1D kinase domain
Drug: nintedanib
Target: Tyrosine-protein kinase receptor Tie-1 (Kinase)
Gene: TIE1
UniProt: P35590 (TIE1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.66
Assay: Binding constant for TIE1 kinase domain
Drug: nintedanib
Target: NT-3 growth factor receptor (Kinase)
Gene: NTRK3
UniProt: Q16288 (NTRK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.49
Assay: Binding constant for TRKC kinase domain
Drug: nintedanib
Target: Tyrosine-protein kinase TXK (Kinase)
Gene: TXK
UniProt: P42681 (TXK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.07
Assay: Binding constant for TXK kinase domain
Drug: nintedanib
Target: Casein kinase II subunit alpha (Kinase)
Gene: CSNK2A1
UniProt: P68400 (CSK21_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.12
Assay: Binding constant for CSNK2A1 kinase domain
Drug: nintedanib
Target: Casein kinase II subunit alpha' (Kinase)
Gene: CSNK2A2
UniProt: P19784 (CSK22_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.05
Assay: Binding constant for CSNK2A2 kinase domain
Drug: nintedanib
Target: Dual specificity tyrosine-phosphorylation-regulated kinase 1B (Kinase)
Gene: DYRK1B
UniProt: Q9Y463 (DYR1B_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.8
Assay: Binding constant for DYRK1B kinase domain
Drug: nintedanib
Target: Inhibitor of nuclear factor kappa-B kinase subunit epsilon (Kinase)
Gene: IKBKE
UniProt: Q14164 (IKKE_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.77
Assay: Binding constant for IKK-epsilon kinase domain
Drug: nintedanib
Target: Serine/threonine-protein kinase STK11 (Kinase)
Gene: STK11
UniProt: Q15831 (STK11_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.74
Assay: Binding constant for LKB1 kinase domain
Drug: nintedanib
Target: Dual specificity mitogen-activated protein kinase kinase 3 (Kinase)
Gene: MAP2K3
UniProt: P46734 (MP2K3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.68
Assay: Binding constant for MEK3 kinase domain
Drug: nintedanib
Target: Maternal embryonic leucine zipper kinase (Kinase)
Gene: MELK
UniProt: Q14680 (MELK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.31
Assay: Binding constant for MELK kinase domain
Drug: nintedanib
Target: Serine/threonine-protein kinase 26 (Kinase)
Gene: STK26
UniProt: Q9P289 (STK26_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.31
Assay: Binding constant for MST4 kinase domain
Drug: nintedanib
Target: Eukaryotic translation initiation factor 2-alpha kinase 4 (Kinase)
Gene: EIF2AK4
UniProt: Q9P2K8 (E2AK4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.7
Assay: Binding constant for GCN2(Kin.Dom.2,S808G) kinase domain
Drug: nintedanib
Target: Insulin receptor-related protein (Kinase)
Gene: INSRR
UniProt: P14616 (INSRR_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.68
Assay: Binding constant for INSRR kinase domain
Drug: nintedanib
Target: Interleukin-1 receptor-associated kinase 3 (Kinase)
Gene: IRAK3
UniProt: Q9Y616 (IRAK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.28
Assay: Binding constant for IRAK3 kinase domain
Drug: nintedanib
Target: Serine/threonine-protein kinase RIO3 (Kinase)
Gene: RIOK3
UniProt: O14730 (RIOK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.44
Assay: Binding constant for RIOK3 kinase domain
Drug: nintedanib
Target: Serine/threonine-protein kinase SIK2 (Kinase)
Gene: SIK2
UniProt: Q9H0K1 (SIK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.55
Assay: Binding constant for SIK2 kinase domain
Drug: nintedanib
Target: SRSF protein kinase 1 (Kinase)
Gene: SRPK1
UniProt: Q96SB4 (SRPK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.43
Assay: Binding constant for SRPK1 kinase domain
Drug: nintedanib
Target: SRSF protein kinase 2 (Kinase)
Gene: SRPK2
UniProt: P78362 (SRPK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.44
Assay: Binding constant for SRPK2 kinase domain
Drug: nintedanib
Target: Serine/threonine-protein kinase 33 (Kinase)
Gene: STK33
UniProt: Q9BYT3 (STK33_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.96
Assay: Binding constant for STK33 kinase domain
Drug: nintedanib
Target: 5'-AMP-activated protein kinase catalytic subunit alpha-2 (Kinase)
Gene: PRKAA2
UniProt: P54646 (AAPK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.08
Assay: Binding constant for AMPK-alpha2 kinase domain
Drug: nintedanib
Target: Discoidin domain-containing receptor 2 (Kinase)
Gene: DDR2
UniProt: Q16832 (DDR2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.38
Assay: Binding constant for DDR2 kinase domain
Drug: nintedanib
Target: Serine/threonine-protein kinase LATS1 (Kinase)
Gene: LATS1
UniProt: O95835 (LATS1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.38
Assay: Binding constant for LATS1 kinase domain
Drug: nintedanib
Target: Serine/threonine-protein kinase LATS2 (Kinase)
Gene: LATS2
UniProt: Q9NRM7 (LATS2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.42
Assay: Binding constant for LATS2 kinase domain
Drug: nintedanib
Target: Leukocyte tyrosine kinase receptor (Kinase)
Gene: LTK
UniProt: P29376 (LTK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.82
Assay: Binding constant for LTK kinase domain
Drug: nintedanib
Target: Mitogen-activated protein kinase kinase kinase kinase 1 (Kinase)
Gene: MAP4K1
UniProt: Q92918 (M4K1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.46
Assay: Binding constant for HPK1 kinase domain
Drug: nintedanib
Target: Serine/threonine-protein kinase PAK 7 (Kinase)
Gene: PAK5
UniProt: Q9P286 (PAK5_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.89
Assay: Binding constant for PAK7 kinase domain
Drug: nintedanib
Target: NUAK family SNF1-like kinase 1 (Kinase)
Gene: NUAK1
UniProt: O60285 (NUAK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.8
Assay: Binding constant for ARK5 kinase domain
Drug: nintedanib
Target: Mitogen-activated protein kinase kinase kinase kinase 3 (Kinase)
Gene: MAP4K3
UniProt: Q8IVH8 (M4K3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.54
Assay: Binding constant for MAP4K3 kinase domain
Drug: nintedanib
Target: Aurora kinase B (Kinase)
Gene: AURKB
UniProt: Q96GD4 (AURKB_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.38
Assay: Binding constant for AURKB kinase domain
Drug: nintedanib
Target: Tyrosine-protein kinase Blk (Kinase)
Gene: BLK
UniProt: P51451 (BLK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.42
Assay: Binding constant for BLK kinase domain
Drug: nintedanib
Target: Bone morphogenetic protein receptor type-2 (Kinase)
Gene: BMPR2
UniProt: Q13873 (BMPR2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.25
Assay: Binding constant for BMPR2 kinase domain
Drug: nintedanib
Target: Mitogen-activated protein kinase kinase kinase kinase 4 (Kinase)
Gene: MAP4K4
UniProt: O95819 (M4K4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.82
Assay: Binding constant for MAP4K4 kinase domain
Drug: nintedanib
Target: Serine/threonine-protein kinase MARK1 (Kinase)
Gene: MARK1
UniProt: Q9P0L2 (MARK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.85
Assay: Binding constant for MARK1 kinase domain
Drug: nintedanib
Target: MAP/microtubule affinity-regulating kinase 4 (Kinase)
Gene: MARK4
UniProt: Q96L34 (MARK4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.7
Assay: Binding constant for MARK4 kinase domain
Drug: nintedanib
Target: Dual specificity mitogen-activated protein kinase kinase 4 (Kinase)
Gene: MAP2K4
UniProt: P45985 (MP2K4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.43
Assay: Binding constant for MEK4 kinase domain
Drug: nintedanib
Target: Tyrosine-protein kinase Mer (Kinase)
Gene: MERTK
UniProt: Q12866 (MERTK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.07
Assay: Binding constant for MERTK kinase domain
Drug: nintedanib
Target: Calcium/calmodulin-dependent protein kinase type IV (Kinase)
Gene: CAMK4
UniProt: Q16566 (KCC4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.43
Assay: Binding constant for CAMK4 kinase domain
Drug: nintedanib
Target: Mitogen-activated protein kinase kinase kinase 9 (Kinase)
Gene: MAP3K9
UniProt: P80192 (M3K9_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.66
Assay: Binding constant for MLK1 kinase domain
Drug: nintedanib
Target: Mitogen-activated protein kinase kinase kinase 10 (Kinase)
Gene: MAP3K10
UniProt: Q02779 (M3K10_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.64
Assay: Binding constant for MLK2 kinase domain
Drug: nintedanib
Target: Mitogen-activated protein kinase kinase kinase 11 (Kinase)
Gene: MAP3K11
UniProt: Q16584 (M3K11_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.15
Assay: Binding constant for MLK3 kinase domain
Drug: nintedanib
Target: Serine/threonine-protein kinase 24 (Kinase)
Gene: STK24
UniProt: Q9Y6E0 (STK24_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.96
Assay: Binding constant for MST3 kinase domain
Drug: nintedanib
Target: Muscle, skeletal receptor tyrosine-protein kinase (Kinase)
Gene: MUSK
UniProt: O15146 (MUSK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.23
Assay: Binding constant for MUSK kinase domain
Drug: nintedanib
Target: Serine/threonine-protein kinase DCLK1 (Kinase)
Gene: DCLK1
UniProt: O15075 (DCLK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.27
Assay: Binding constant for DCAMKL1 kinase domain
Drug: nintedanib
Target: Myosin-IIIb (Kinase)
Gene: MYO3B
UniProt: Q8WXR4 (MYO3B_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.57
Assay: Binding constant for MYO3B kinase domain
Drug: nintedanib
Target: Serine/threonine-protein kinase PAK 2 (Kinase)
Gene: PAK2
UniProt: Q13177 (PAK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.48
Assay: Binding constant for PAK2 kinase domain
Drug: nintedanib
Target: Serine/threonine-protein kinase PAK 4 (Kinase)
Gene: PAK4
UniProt: O96013 (PAK4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.52
Assay: Binding constant for PAK4 kinase domain
Drug: nintedanib
Target: Serine/threonine-protein kinase SIK1 (Kinase)
Gene: SIK1
UniProt: P57059 (SIK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.17
Assay: Binding constant for SIK kinase domain
Drug: nintedanib
Target: TGF-beta receptor type-1 (Kinase)
Gene: TGFBR1
UniProt: P36897 (TGFR1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.38
Assay: Binding constant for TGFBR1 kinase domain
Drug: nintedanib
Target: Ephrin type-A receptor 1 (Kinase)
Gene: EPHA1
UniProt: P21709 (EPHA1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.92
Assay: Binding constant for EPHA1 kinase domain
Drug: nintedanib
Target: Mitogen-activated protein kinase 7 (Kinase)
Gene: MAPK7
UniProt: Q13164 (MK07_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.6
Assay: Binding constant for ERK5 kinase domain
Drug: nintedanib
Target: Serine/threonine-protein kinase D2 (Kinase)
Gene: PRKD2
UniProt: Q9BZL6 (KPCD2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.14
Assay: Binding constant for PRKD2 kinase domain
Drug: nintedanib
Target: Serine/threonine-protein kinase D3 (Kinase)
Gene: PRKD3
UniProt: O94806 (KPCD3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.19
Assay: Binding constant for PRKD3 kinase domain
Drug: nintedanib
Target: Receptor-interacting serine/threonine-protein kinase 1 (Kinase)
Gene: RIPK1
UniProt: Q13546 (RIPK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.62
Assay: Binding constant for RIPK1 kinase domain
Drug: nintedanib
Target: Tyrosine-protein kinase Fes/Fps (Kinase)
Gene: FES
UniProt: P07332 (FES_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.92
Assay: Binding constant for FES kinase domain
Drug: nintedanib
Target: Fibroblast growth factor receptor 4 (Kinase)
Gene: FGFR4
UniProt: P22455 (FGFR4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.74
Action type: INHIBITOR
Assay: Binding constant for FGFR4 kinase domain
Drug: nintedanib
Target: Proto-oncogene tyrosine-protein kinase ROS (Kinase)
Gene: ROS1
UniProt: P08922 (ROS1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.43
Assay: Binding constant for ROS1 kinase domain
Drug: nintedanib
Target: Ribosomal protein S6 kinase alpha-1 (Kinase)
Gene: RPS6KA1
UniProt: Q15418 (KS6A1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.74
Assay: Binding constant for RSK1(Kin.Dom.1-N-terminal) kinase domain
Drug: nintedanib
Target: Ribosomal protein S6 kinase alpha-4 (Kinase)
Gene: RPS6KA4
UniProt: O75676 (KS6A4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.21
Assay: Binding constant for RPS6KA4(Kin.Dom.1-N-terminal) kinase domain
Drug: nintedanib
Target: Mitogen-activated protein kinase kinase kinase kinase 2 (Kinase)
Gene: MAP4K2
UniProt: Q12851 (M4K2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.54
Assay: Binding constant for MAP4K2 kinase domain
Drug: nintedanib
Target: Misshapen-like kinase 1 (Kinase)
Gene: MINK1
UniProt: Q8N4C8 (MINK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.09
Assay: Binding constant for MINK kinase domain
Drug: nintedanib
Target: Serine/threonine-protein kinase TBK1 (Kinase)
Gene: TBK1
UniProt: Q9UHD2 (TBK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.82
Assay: Binding constant for TBK1 kinase domain
Drug: nintedanib
Target: Interleukin-1 receptor-associated kinase 4 (Kinase)
Gene: IRAK4
UniProt: Q9NWZ3 (IRAK4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.09
Assay: Binding constant for IRAK4 kinase domain
Drug: nintedanib
Target: Cyclin-dependent kinase 4 (Kinase)
Gene: CDK4
UniProt: P11802 (CDK4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.8
Assay: Binding constant for CDK4-cyclinD1 kinase domain
Drug: nintedanib
Target: Cyclin-dependent kinase-like 2 (Kinase)
Gene: CDKL2
UniProt: Q92772 (CDKL2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.89
Assay: Binding constant for CDKL2 kinase domain
Drug: nintedanib
Target: Ephrin type-B receptor 6 (Kinase)
Gene: EPHB6
UniProt: O15197 (EPHB6_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.85
Assay: Binding constant for EPHB6 kinase domain
Drug: nintedanib
Target: Serine/threonine-protein kinase/endoribonuclease IRE1 (Kinase)
Gene: ERN1
UniProt: O75460 (ERN1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.7
Assay: Binding constant for ERN1 kinase domain
Drug: nintedanib
Target: Rhodopsin kinase (Kinase)
Gene: GRK1
UniProt: Q15835 (RK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6
Assay: Binding constant for GRK1 kinase domain
Drug: nintedanib
Target: G protein-coupled receptor kinase 4 (Kinase)
Gene: GRK4
UniProt: P32298 (GRK4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.77
Assay: Binding constant for GRK4 kinase domain
Drug: nintedanib
Target: G protein-coupled receptor kinase 7 (Kinase)
Gene: GRK7
UniProt: Q8WTQ7 (GRK7_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.92
Assay: Binding constant for GRK7 kinase domain
Drug: nintedanib
Target: Homeodomain-interacting protein kinase 2 (Kinase)
Gene: HIPK2
UniProt: Q9H2X6 (HIPK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.1
Assay: Binding constant for HIPK2 kinase domain
Drug: nintedanib
Target: Homeodomain-interacting protein kinase 3 (Kinase)
Gene: HIPK3
UniProt: Q9H422 (HIPK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.07
Assay: Binding constant for HIPK3 kinase domain
Drug: nintedanib
Target: Homeodomain-interacting protein kinase 4 (Kinase)
Gene: HIPK4
UniProt: Q8NE63 (HIPK4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.92
Assay: Binding constant for HIPK4 kinase domain
Drug: nintedanib
Target: Serine/threonine-protein kinase ICK (Kinase)
Gene: ICK
UniProt: Q9UPZ9 (ICK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.77
Assay: Binding constant for ICK kinase domain
Drug: nintedanib
Target: Inhibitor of nuclear factor kappa-B kinase subunit alpha (Kinase)
Gene: CHUK
UniProt: O15111 (IKKA_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.35
Assay: Binding constant for IKK-alpha kinase domain
Drug: nintedanib
Target: Interleukin-1 receptor-associated kinase 1 (Kinase)
Gene: IRAK1
UniProt: P51617 (IRAK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.92
Assay: Binding constant for IRAK1 kinase domain
Drug: nintedanib
Target: Mitogen-activated protein kinase kinase kinase 13 (Kinase)
Gene: MAP3K13
UniProt: O43283 (M3K13_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.85
Assay: Binding constant for LZK kinase domain
Drug: nintedanib
Target: Mitogen-activated protein kinase kinase kinase 2 (Kinase)
Gene: MAP3K2
UniProt: Q9Y2U5 (M3K2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.03
Assay: Binding constant for MAP3K2 kinase domain
Drug: nintedanib
Target: Mitogen-activated protein kinase kinase kinase 3 (Kinase)
Gene: MAP3K3
UniProt: Q99759 (M3K3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.47
Assay: Binding constant for MAP3K3 kinase domain
Drug: nintedanib
Target: Microtubule-associated serine/threonine-protein kinase 1 (Kinase)
Gene: MAST1
UniProt: Q9Y2H9 (MAST1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.34
Assay: Binding constant for MAST1 kinase domain
Drug: nintedanib
Target: Serine/threonine-protein kinase OSR1 (Kinase)
Gene: OXSR1
UniProt: O95747 (OXSR1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.89
Assay: Binding constant for OSR1 kinase domain
Drug: nintedanib
Target: SRSF protein kinase 3 (Kinase)
Gene: SRPK3
UniProt: Q9UPE1 (SRPK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.92
Assay: Binding constant for SRPK3 kinase domain
Drug: nintedanib
Target: STE20/SPS1-related proline-alanine-rich protein kinase (Kinase)
Gene: STK39
UniProt: Q9UEW8 (STK39_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.28
Assay: Binding constant for STK39 kinase domain
Drug: nintedanib
Target: Mitogen-activated protein kinase kinase kinase 7 (Kinase)
Gene: MAP3K7
UniProt: O43318 (M3K7_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.39
Assay: Binding constant for TAK1 kinase domain
Drug: nintedanib
Target: Serine/threonine-protein kinase ULK1 (Kinase)
Gene: ULK1
UniProt: O75385 (ULK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.47
Assay: Binding constant for ULK1 kinase domain
Drug: nintedanib
Target: Serine/threonine-protein kinase ULK2 (Kinase)
Gene: ULK2
UniProt: Q8IYT8 (ULK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.42
Assay: Binding constant for ULK2 kinase domain
Drug: nintedanib
Target: Serine/threonine-protein kinase ULK3 (Kinase)
Gene: ULK3
UniProt: Q6PHR2 (ULK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.22
Assay: Binding constant for ULK3 kinase domain
Drug: nintedanib
Target: Mitogen-activated protein kinase kinase kinase 19 (Kinase)
Gene: MAP3K19
UniProt: Q56UN5 (M3K19_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.28
Assay: Binding constant for YSK4 kinase domain
Drug: nintedanib
Target: Homeodomain-interacting protein kinase 1 (Kinase)
Gene: HIPK1
UniProt: Q86Z02 (HIPK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.89
Assay: Binding constant for HIPK1 kinase domain
Drug: nintedanib
Target: Mitogen-activated protein kinase kinase kinase 15 (Kinase)
Gene: MAP3K15
UniProt: Q6ZN16 (M3K15_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.85
Assay: Binding constant for MAP3K15 kinase domain
Drug: nintedanib
Target: Receptor-interacting serine/threonine-protein kinase 4 (Kinase)
Gene: RIPK4
UniProt: P57078 (RIPK4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.36
Assay: Binding constant for RIPK4 kinase domain
Drug: nintedanib
Target: Uncharacterized serine/threonine-protein kinase SBK3 (Kinase)
Gene: SBK3
UniProt: P0C264 (SBK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.7
Assay: Binding constant for SgK110 kinase domain
Drug: nintedanib
Target: Serine/threonine-protein kinase 35 (Kinase)
Gene: STK35
UniProt: Q8TDR2 (STK35_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.09
Assay: Binding constant for STK35 kinase domain
Drug: nintedanib
Target: Serine/threonine-protein kinase SBK1 (Kinase)
Gene: SBK1
UniProt: Q52WX2 (SBK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.96
Assay: Binding constant for SBK1 kinase domain
Drug: nintedanib
Target: Serine/threonine-protein kinase PRP4 homolog (Kinase)
Gene: PRPF4B
UniProt: Q13523 (PRP4B_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.08
Assay: Binding constant for PRP4 kinase domain
Drug: nintedanib
Target: Mitogen-activated protein kinase kinase kinase 12 (Kinase)
Gene: MAP3K12
UniProt: Q12852 (M3K12_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.85
Assay: Binding constant for DLK kinase domain
Drug: nintedanib
Target: Serine/threonine-protein kinase Sgk3 (Kinase)
Gene: SGK3
UniProt: Q96BR1 (SGK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6
Assay: Binding constant for SGK3 kinase domain
Drug: nintedanib
Target: Dual specificity mitogen-activated protein kinase kinase 5 (Kinase)
Gene: MAP2K5
UniProt: Q13163 (MP2K5_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.74
Assay: Binding constant for MEK5 kinase domain
Drug: nintedanib
Target: Myosin light chain kinase 3 (Kinase)
Gene: MYLK3
UniProt: Q32MK0 (MYLK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.96
Assay: Binding constant for MLCK kinase domain
Drug: nintedanib
Target: Leucine-rich repeat serine/threonine-protein kinase 2 (Kinase)
Gene: LRRK2
UniProt: Q5S007 (LRRK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.43
Assay: Binding constant for LRRK2(G2019S) kinase domain
Drug: nintedanib
Target: Calcium-dependent protein kinase 1 (Kinase)
Gene: CPK1
UniProt: P62344 (CDPK1_PLAF7)
Organism: Plasmodium falciparum
Activity: Kd = 5.92
Assay: Binding constant for PFCDPK1(P.falciparum) kinase domain
Drug: nintedanib
Target: Vascular endothelial growth factor receptor 2 (Kinase)
Gene: Kdr
UniProt: P35918 (VGFR2_MOUSE)
Organism: Mus musculus
Activity: IC50 = 7.89
Assay: Inhibition of mouse GST-fused VEGFR2 expressed in Sf9 insect cells after 20 mins by scintillation counting
Drug: nintedanib
Target: Serine/threonine-protein kinase PknB (Kinase)
Gene: pknB
UniProt: P9WI81 (PKNB_MYCTU)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Activity: Kd = 8.44
Assay: Binding constant for PKNB(M.tuberculosis) kinase domain
Drug: nintedanib
Target: cGMP-dependent protein kinase 1 (Kinase)
Gene: PRKG1
UniProt: Q13976 (KGP1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.85
Assay: Binding constant for PRKG1 kinase domain
Drug: nintedanib
Target: Vascular endothelial growth factor receptor 1 (Kinase)
Gene: FLT1
UniProt: P17948 (VGFR1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.983
Action type: INHIBITOR