AIM-Harvard/TrialPanorama-filtered huggingface dataset:
Drug: ifenprodil
Target: Glutamate receptor ionotropic, NMDA 1 (Ion channel)
Gene: Grin1
UniProt: P35439 (NMDZ1_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 7.14
Assay: Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current by two electrode voltage clamp method
Drug: ifenprodil
Target: Sigma non-opioid intracellular receptor 1 (Membrane receptor)
Gene: Sigmar1
UniProt: Q9R0C9 (SGMR1_RAT)
Organism: Rattus norvegicus
Activity: Ki = 8.7
Assay: Displacement of [3H](+)-pentazocine from sigma1 receptor in rat liver membrane by liquid scintillation counting
Drug: ifenprodil
Target: Alpha-2A adrenergic receptor (GPCR)
Gene: Adra2a
UniProt: P22909 (ADA2A_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 6.96
Assay: Compound was tested for the binding affinity against Alpha-1 adrenergic receptor by using [3H]prazosin as radioligand
Drug: ifenprodil
Target: 5-hydroxytryptamine receptor 1A (GPCR)
Gene: Htr1a
UniProt: Q64264 (5HT1A_MOUSE)
Organism: Mus musculus
Activity: IC50 = 6.62
Assay: Compound was tested for the binding affinity against 5-hydroxytryptamine 1A receptor by using [3H]DPAT as radioligand
Drug: ifenprodil
Target: 5-hydroxytryptamine receptor 2A (GPCR)
Gene: HTR2A
UniProt: Q75Z89 (5HT2A_BOVIN)
Organism: Bos taurus
Activity: IC50 = 6.21
Assay: Compound was tested for the binding affinity against 5-hydroxytryptamine 2 receptor by using [3H]ketanserin as radioligand
Drug: ifenprodil
Target: Sigma non-opioid intracellular receptor 1 (Membrane other)
Gene: SIGMAR1
UniProt: Q60492 (SGMR1_CAVPO)
Organism: Cavia porcellus
Activity: Ki = 8.99
Assay: Displacement of [3H]-(+)-pentazocine from guinea pig brain sigma1 receptor after 150 mins by scintillation counting analysis
Drug: ifenprodil
Target: Glutamate NMDA receptor; GRIN1/GRIN2B (Ion channel)
Gene: GRIN1|GRIN2B
UniProt: Q05586|Q13224 (NMDZ1_HUMAN|NMDE2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8
Assay: Displacement of [3H]ifenprodil from human recombinant NR1-1a/NR2B receptor expressed in mouse L(tk-) cells after 120 mins by scintillation counting
Drug: ifenprodil
Target: Adrenergic receptor alpha-1 (GPCR)
Gene: Adra1b|Adra1d|Adra1a
UniProt: P15823|P23944|P43140 (ADA1B_RAT|ADA1D_RAT|ADA1A_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 7
Assay: Compound was tested for the binding affinity against Alpha-1 adrenergic receptor
Drug: ifenprodil
Target: Glutamate [NMDA] receptor subunit epsilon 2 (Ion channel)
Gene: Grin2b
UniProt: Q00960 (NMDE2_RAT)
Organism: Rattus norvegicus
Activity: Ki = 7.96
Assay: Displacement of [3H]ifenprodil from rat brain membrane NR2B receptor
Drug: ifenprodil
Target: 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase (Unclassified)
Gene: EBP
UniProt: Q60490 (EBP_CAVPO)
Organism: Cavia porcellus
Activity: Ki = 8.57
Assay: Inhibition of [3H]-emopamil binding to Sterol delta 8-delta 7 isomerase in guinea pig liver membrane
Drug: ifenprodil
Target: Sigma intracellular receptor 2 (Unclassified)
Gene: Tmem97
UniProt: Q5U3Y7 (SGMR2_RAT)
Organism: Rattus norvegicus
Activity: Ki = 7.01
Assay: Displacement of [3H]-di-o-tolylguanidine from sigma2 receptor in rat liver membranes incubated for 120 mins by scintillation counting method
Drug: iloprost
Target: Prostaglandin E2 receptor EP1 subtype (GPCR)
Gene: PTGER1
UniProt: P34995 (PE2R1_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 7.7
Drug: iloprost
Target: Prostaglandin E2 receptor EP3 subtype (GPCR)
Gene: PTGER3
UniProt: P43115 (PE2R3_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 7.3
Drug: iloprost
Target: Prostacyclin receptor (GPCR)
Gene: PTGIR
UniProt: P43119 (PI2R_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 7.75
Action type: AGONIST
Drug: iloprost
Target: Thromboxane A2 receptor (GPCR)
Gene: TBXA2R
UniProt: P21731 (TA2R_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.2
Action type: AGONIST
Drug: iloprost
Target: Prostaglandin E2 receptor EP2 subtype (GPCR)
Gene: PTGER2
UniProt: P43116 (PE2R2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.7
Action type: AGONIST
Drug: iloprost
Target: Prostaglandin E2 receptor EP4 subtype (GPCR)
Gene: PTGER4
UniProt: P35408 (PE2R4_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.68
Action type: AGONIST
Drug: iloprost
Target: Prostaglandin D2 receptor (GPCR)
Gene: PTGDR
UniProt: Q13258 (PD2R_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.6
Action type: AGONIST
Drug: iloprost
Target: Prostaglandin F2-alpha receptor (GPCR)
Gene: PTGFR
UniProt: P43088 (PF2R_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.2
Action type: AGONIST
Drug: iloprost
Target: Prostaglandin E2 receptor EP1 subtype (GPCR)
Gene: Ptger1
UniProt: P35375 (PE2R1_MOUSE)
Organism: Mus musculus
Activity: Ki = 7.7
Action type: AGONIST
Drug: iloprost
Target: Prostaglandin E2 receptor EP2 subtype (GPCR)
Gene: Ptger2
UniProt: Q62053 (PE2R2_MOUSE)
Organism: Mus musculus
Activity: Ki = 5.8
Action type: AGONIST
Drug: iloprost
Target: Prostaglandin E2 receptor EP3 subtype (GPCR)
Gene: Ptger3
UniProt: P30557 (PE2R3_MOUSE)
Organism: Mus musculus
Activity: Ki = 7.66
Action type: AGONIST
Drug: iloprost
Target: Prostaglandin E2 receptor EP4 subtype (GPCR)
Gene: Ptger4
UniProt: P32240 (PE2R4_MOUSE)
Organism: Mus musculus
Activity: Ki = 5.6
Action type: AGONIST
Drug: iloprost
Target: Prostaglandin E2 receptor EP2 subtype (GPCR)
Gene: Ptger2
UniProt: Q62928 (PE2R2_RAT)
Organism: Rattus norvegicus
Activity: Ki = 5.9
Action type: AGONIST
Drug: iloprost
Target: Prostacyclin receptor (GPCR)
Gene: Ptgir
UniProt: P43252 (PI2R_MOUSE)
Organism: Mus musculus
Activity: Ki = 8
Action type: AGONIST
Drug: iloprost
Target: Prostacyclin receptor (GPCR)
Gene: Ptgir
UniProt: P43253 (PI2R_RAT)
Organism: Rattus norvegicus
Activity: EC50 = 9.16
Assay: Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
Drug: iloprost
Target: Prostaglandin E2 receptor EP3 subtype (GPCR)
Gene: Ptger3
UniProt: P34980 (PE2R3_RAT)
Organism: Rattus norvegicus
Activity: EC50 = 9.2
Action type: AGONIST
Drug: iloprost
Target: Prostaglandin E2 receptor EP1 subtype (GPCR)
Gene: Ptger1
UniProt: P70597 (PE2R1_RAT)
Organism: Rattus norvegicus
Activity: Ki = 7.9
Action type: AGONIST
Drug: imatinib
Target: Multidrug resistance protein 1 (Transporter)
Gene: ABCB1
UniProt: P08183 (MDR1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.14
Assay: Inhibition of P-glycoprotein expressed in A2780/ADR cells by calcein AM assay
Drug: imatinib
Target: Sodium-dependent serotonin transporter (Transporter)
Gene: SLC6A4
UniProt: P31645 (SC6A4_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.128
Assay: DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine)
Drug: imatinib
Target: 5-hydroxytryptamine receptor 2A (GPCR)
Gene: HTR2A
UniProt: P28223 (5HT2A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.268
Assay: DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin)
Drug: imatinib
Target: Histamine H2 receptor (GPCR)
Gene: HRH2
UniProt: P25021 (HRH2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.714
Assay: DRUGMATRIX: Histamine H2 radioligand binding (ligand: [125I] Aminopotentidine)
Drug: imatinib
Target: Carbonic anhydrase 2 (Enzyme)
Gene: CA2
UniProt: P00918 (CAH2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.52
Assay: Inhibition of human carbonic anhydrase 2 by stopped flow CO2 hydration assay
Drug: imatinib
Target: Multidrug resistance-associated protein 1 (Transporter)
Gene: ABCC1
UniProt: P33527 (MRP1_HUMAN)
Organism: Homo sapiens
Drug: imatinib
Target: ATP-binding cassette sub-family G member 2 (Transporter)
Gene: ABCG2
UniProt: Q9UNQ0 (ABCG2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.47
Assay: Inhibition of BCRP expressed in MDCK cells by pheophorbide A assay
Drug: imatinib
Target: Carbonic anhydrase 1 (Enzyme)
Gene: CA1
UniProt: P00915 (CAH1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.5
Assay: Inhibition of human carbonic anhydrase 1 by stopped flow CO2 hydration assay
Drug: imatinib
Target: Carbonic anhydrase 4 (Enzyme)
Gene: CA4
UniProt: P22748 (CAH4_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.34
Assay: Inhibition of human carbonic anhydrase 4 by stopped flow CO2 hydration assay
Drug: imatinib
Target: Ribosyldihydronicotinamide dehydrogenase [quinone] (Enzyme)
Gene: NQO2
UniProt: P16083 (NQO2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.4
Assay: Competitive inhibition of human recombinant NQO2-mediated mitomycin C metabolism using NADH as cosubstrate incubated for 5 mins prior to NADH addition measured after 30 mins by Michaelis-Menten plot analysis
Drug: imatinib
Target: Carbonic anhydrase 9 (Enzyme)
Gene: CA9
UniProt: Q16790 (CAH9_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.12
Assay: Inhibition of human carbonic anhydrase 9 by stopped flow CO2 hydration assay
Drug: imatinib
Target: Carbonic anhydrase 12 (Enzyme)
Gene: CA12
UniProt: O43570 (CAH12_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.01
Assay: Inhibition of human carbonic anhydrase 12 by stopped flow CO2 hydration assay
Drug: imatinib
Target: Platelet-derived growth factor receptor beta (Kinase)
Gene: PDGFRB
UniProt: P09619 (PGFRB_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.85
Action type: INHIBITOR
Assay: Binding constant for PDGFRB kinase domain
Drug: imatinib
Target: Tyrosine-protein kinase ABL1 (Kinase)
Gene: ABL1
UniProt: P00519 (ABL1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.96
Action type: INHIBITOR
Assay: Binding constant for ABL1-non phosphorylated kinase domain
Drug: imatinib
Target: Mast/stem cell growth factor receptor Kit (Kinase)
Gene: KIT
UniProt: P10721 (KIT_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.89
Action type: INHIBITOR
Assay: Binding constant for KIT kinase domain
Drug: imatinib
Target: Epidermal growth factor receptor (Kinase)
Gene: EGFR
UniProt: P00533 (EGFR_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.12
Assay: Binding constant for EGFR(L747-E749del, A750P) kinase domain
Drug: imatinib
Target: Carbonic anhydrase 5A, mitochondrial (Enzyme)
Gene: CA5A
UniProt: P35218 (CAH5A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 4.69
Assay: Inhibition of human carbonic anhydrase 5A by stopped flow CO2 hydration assay
Drug: imatinib
Target: Carbonic anhydrase 5B, mitochondrial (Enzyme)
Gene: CA5B
UniProt: Q9Y2D0 (CAH5B_HUMAN)
Organism: Homo sapiens
Activity: Ki = 4.77
Assay: Inhibition of human carbonic anhydrase 5B by stopped flow CO2 hydration assay
Drug: imatinib
Target: Carbonic anhydrase 7 (Enzyme)
Gene: CA7
UniProt: P43166 (CAH7_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.96
Assay: Inhibition of human carbonic anhydrase 7 by stopped flow CO2 hydration assay
Drug: imatinib
Target: Proto-oncogene tyrosine-protein kinase Src (Kinase)
Gene: SRC
UniProt: P12931 (SRC_HUMAN)
Organism: Homo sapiens
Activity: Ki = 4.51
Assay: Inhibition of recombinant human c-Src
Drug: imatinib
Target: Tyrosine-protein kinase Lck (Kinase)
Gene: LCK
UniProt: P06239 (LCK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.4
Assay: Binding constant for LCK kinase domain
Drug: imatinib
Target: Tyrosine-protein kinase Fyn (Kinase)
Gene: FYN
UniProt: P06241 (FYN_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.51
Assay: Binding constant for FYN kinase domain
Drug: imatinib
Target: RAF proto-oncogene serine/threonine-protein kinase (Kinase)
Gene: RAF1
UniProt: P04049 (RAF1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.77
Assay: Binding constant for RAF1 kinase domain
Drug: imatinib
Target: Serine/threonine-protein kinase B-raf (Kinase)
Gene: BRAF
UniProt: P15056 (BRAF_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.48
Assay: Binding constant for BRAF(V600E) kinase domain
Drug: imatinib
Target: Receptor-type tyrosine-protein kinase FLT3 (Kinase)
Gene: FLT3
UniProt: P36888 (FLT3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.2
Assay: Binding constant for FLT3(ITD) kinase domain
Drug: imatinib
Target: Vascular endothelial growth factor receptor 2 (Kinase)
Gene: KDR
UniProt: P35968 (VGFR2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.59
Assay: Inhibition of VEGFR2 by liquid scintillation counting
Drug: imatinib
Target: Macrophage colony-stimulating factor 1 receptor (Kinase)
Gene: CSF1R
UniProt: P07333 (CSF1R_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.96
Assay: Binding constant for CSF1R kinase domain
Drug: imatinib
Target: Platelet-derived growth factor receptor alpha (Kinase)
Gene: PDGFRA
UniProt: P16234 (PGFRA_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.51
Assay: Binding constant for PDGFRA kinase domain
Drug: imatinib
Target: Insulin receptor (Kinase)
Gene: INSR
UniProt: P06213 (INSR_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5
Action type: AGONIST
Drug: imatinib
Target: Thromboxane-A synthase (Enzyme)
Gene: TBXAS1
UniProt: P24557 (THAS_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.703
Assay: DRUGMATRIX: Thromboxane Synthetase enzyme inhibition (substrate: PGH2)
Drug: imatinib
Target: Mitogen-activated protein kinase 8 (Kinase)
Gene: MAPK8
UniProt: P45983 (MK08_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.49
Assay: Average Binding Constant for JNK1; NA=Not Active at 10 uM
Drug: imatinib
Target: Carbonic anhydrase 3 (Enzyme)
Gene: CA3
UniProt: P07451 (CAH3_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.28
Assay: Inhibition of human carbonic anhydrase 3 by stopped flow CO2 hydration assay
Drug: imatinib
Target: Carbonic anhydrase 6 (Enzyme)
Gene: CA6
UniProt: P23280 (CAH6_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.41
Assay: Inhibition of human carbonic anhydrase 6 by stopped flow CO2 hydration assay
Drug: imatinib
Target: Mitogen-activated protein kinase 10 (Kinase)
Gene: MAPK10
UniProt: P53779 (MK10_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.51
Assay: Binding constant for JNK3 kinase domain
Drug: imatinib
Target: Tyrosine-protein kinase JAK2 (Kinase)
Gene: JAK2
UniProt: O60674 (JAK2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5
Drug: imatinib
Target: Tyrosine-protein kinase SYK (Kinase)
Gene: SYK
UniProt: P43405 (KSYK_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.3
Assay: Inhibition of recombinant Syk
Drug: imatinib
Target: Ephrin type-A receptor 8 (Kinase)
Gene: EPHA8
UniProt: P29322 (EPHA8_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.85
Assay: Binding constant for EPHA8 kinase domain
Drug: imatinib
Target: Tyrosine-protein kinase Lyn (Kinase)
Gene: LYN
UniProt: P07948 (LYN_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.05
Assay: Binding constant for LYN kinase domain
Drug: imatinib
Target: Cytoplasmic tyrosine-protein kinase BMX (Kinase)
Gene: BMX
UniProt: P51813 (BMX_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5
Drug: imatinib
Target: Carbonic anhydrase 14 (Enzyme)
Gene: CA14
UniProt: Q9ULX7 (CAH14_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.33
Assay: Inhibition of human carbonic anhydrase 14 by stopped flow CO2 hydration assay
Drug: imatinib
Target: Fibroblast growth factor receptor 1 (Kinase)
Gene: FGFR1
UniProt: P11362 (FGFR1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5
Drug: imatinib
Target: Serine/threonine-protein kinase PLK4 (Kinase)
Gene: PLK4
UniProt: O00444 (PLK4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.11
Assay: Binding constant for PLK4 kinase domain
Drug: imatinib
Target: Abelson tyrosine-protein kinase 2 (Kinase)
Gene: ABL2
UniProt: P42684 (ABL2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.22
Assay: Binding affinity to human active site of N-terminal hexahistidine-tagged ABL2 expressed in Trichoplusia ni infected Sf9 cells by isothermal titration calorimetric assay
Drug: imatinib
Target: Fibroblast growth factor receptor 2 (Kinase)
Gene: FGFR2
UniProt: P21802 (FGFR2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5
Drug: imatinib
Target: Serine/threonine-protein kinase 17A (Kinase)
Gene: STK17A
UniProt: Q9UEE5 (ST17A_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.55
Assay: Average Binding Constant for STK17A; NA=Not Active at 10 uM
Drug: imatinib
Target: Tyrosine-protein kinase Fgr (Kinase)
Gene: FGR
UniProt: P09769 (FGR_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.62
Assay: Binding constant for FGR kinase domain
Drug: imatinib
Target: Mitogen-activated protein kinase 14 (Kinase)
Gene: MAPK14
UniProt: Q16539 (MK14_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.86
Assay: Inhibition of p38alpha
Drug: imatinib
Target: Tyrosine-protein kinase FRK (Kinase)
Gene: FRK
UniProt: P42685 (FRK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.82
Assay: Binding constant for FRK kinase domain
Drug: imatinib
Target: Dual specificity protein kinase CLK1 (Kinase)
Gene: CLK1
UniProt: P49759 (CLK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.35
Assay: Average Binding Constant for CLK1; NA=Not Active at 10 uM
Drug: imatinib
Target: Cyclin-G-associated kinase (Kinase)
Gene: GAK
UniProt: O14976 (GAK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6
Assay: Binding constant for GAK kinase domain
Drug: imatinib
Target: Ephrin type-B receptor 1 (Kinase)
Gene: EPHB1
UniProt: P54762 (EPHB1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5
Drug: imatinib
Target: Dual specificity protein kinase CLK4 (Kinase)
Gene: CLK4
UniProt: Q9HAZ1 (CLK4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.68
Assay: Binding constant for CLK4 kinase domain
Drug: imatinib
Target: Mitogen-activated protein kinase 9 (Kinase)
Gene: MAPK9
UniProt: P45984 (MK09_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.28
Assay: Average Binding Constant for JNK2; NA=Not Active at 10 uM
Drug: imatinib
Target: Epithelial discoidin domain-containing receptor 1 (Kinase)
Gene: DDR1
UniProt: Q08345 (DDR1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 9.15
Assay: Binding constant for DDR1 kinase domain
Drug: imatinib
Target: Ephrin type-B receptor 4 (Kinase)
Gene: EPHB4
UniProt: P54760 (EPHB4_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5
Drug: imatinib
Target: Lysine--tRNA ligase (Enzyme)
Gene: KARS
UniProt: Q15046 (SYK_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.3
Assay: Inhibition of SYK
Drug: imatinib
Target: Carbonic anhydrase 13 (Enzyme)
Gene: Ca13
UniProt: Q9D6N1 (CAH13_MOUSE)
Organism: Mus musculus
Activity: Ki = 5.13
Assay: Inhibition of mouse carbonic anhydrase 13 by stopped flow CO2 hydration assay
Drug: imatinib
Target: Carbonic anhydrase 15 (Enzyme)
Gene: Ca15
UniProt: Q99N23 (CAH15_MOUSE)
Organism: Mus musculus
Activity: Ki = 7.11
Assay: Inhibition of mouse carbonic anhydrase 15 by stopped flow CO2 hydration assay
Drug: imatinib
Target: Non-receptor tyrosine-protein kinase TYK2 (Kinase)
Gene: TYK2
UniProt: P29597 (TYK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.06
Assay: Binding constant for TYK2(JH2domain-pseudokinase) kinase domain
Drug: imatinib
Target: Proto-oncogene tyrosine-protein kinase Src (Kinase)
Gene: SRC
UniProt: P00523 (SRC_CHICK)
Organism: Gallus gallus
Activity: IC50 = 5.56
Assay: Inhibition of chicken wild-type cSRC (251 to 533)-mediated phosphorylation of biotinylated poly-Glu-Tyr expressed in Escherichia coli BL21(DE3) preincubated for 30 to 60 mins prior to substrate addition by TR-FRET assay
Drug: imatinib
Target: Mitogen-activated protein kinase kinase kinase MLT (Kinase)
Gene: ZAK
UniProt: Q9NYL2 (MLTK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.59
Assay: Binding constant for ZAK kinase domain
Drug: imatinib
Target: Maternal embryonic leucine zipper kinase (Kinase)
Gene: MELK
UniProt: Q14680 (MELK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.72
Assay: Binding constant for full-length MELK
Drug: imatinib
Target: Serine/threonine-protein kinase TNNI3K (Kinase)
Gene: TNNI3K
UniProt: Q59H18 (TNI3K_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.37
Assay: Binding constant for full-length TNNI3K
Drug: imatinib
Target: Discoidin domain-containing receptor 2 (Kinase)
Gene: DDR2
UniProt: Q16832 (DDR2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.82
Assay: Binding constant for DDR2 kinase domain
Drug: imatinib
Target: Tyrosine-protein kinase Blk (Kinase)
Gene: BLK
UniProt: P51451 (BLK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.28
Assay: Binding constant for BLK kinase domain
Drug: imatinib
Target: Cyclin-dependent kinase 19 (Kinase)
Gene: CDK19
UniProt: Q9BWU1 (CDK19_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.26
Assay: Binding constant for CDK11 kinase domain
Drug: imatinib
Target: Tyrosine-protein kinase ABL1 (Kinase)
Gene: Abl1
UniProt: P00520 (ABL1_MOUSE)
Organism: Mus musculus
Activity: IC50 = 7.97
Assay: Inhibition of mouse recombinant N-terminal His6-tagged Abl by radiometric kinase assay
Drug: imatinib
Target: Homeodomain-interacting protein kinase 4 (Kinase)
Gene: HIPK4
UniProt: Q8NE63 (HIPK4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.02
Assay: Binding constant for HIPK4 kinase domain
Drug: imatinib
Target: Interleukin-1 receptor-associated kinase 1 (Kinase)
Gene: IRAK1
UniProt: P51617 (IRAK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.92
Assay: Binding constant for IRAK1 kinase domain
Drug: imatinib
Target: Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (Kinase)
Gene: PIP4K2C
UniProt: Q8TBX8 (PI42C_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.42
Assay: Binding constant for PIP5K2C kinase domain
Drug: imatinib
Target: Solute carrier family 22 member 2 (Transporter)
Gene: SLC22A2
UniProt: O15244 (S22A2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.38
Assay: Inhibition of human OCT2-mediated ASP+ uptake expressed in HEK293 cells after 3 mins by fluorescence assay
Drug: imatinib
Target: Multidrug and toxin extrusion protein 1 (Transporter)
Gene: SLC47A1
UniProt: Q96FL8 (S47A1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7.4
Assay: Inhibition of human MATE1-mediated [14]-metformin uptake expressed in polarized MDCK2 cells after 5 mins by liquid scintillation counting analysis
Drug: imatinib
Target: Multidrug and toxin extrusion protein 2 (Transporter)
Gene: SLC47A2
UniProt: Q86VL8 (S47A2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.46
Assay: Inhibition of human MATE2K-mediated ASP+ uptake expressed in HEK293 cells up to 500 uM after 1.5 mins by fluorescence assay
Drug: imatinib
Target: Solute carrier family 22 member 3 (Transporter)
Gene: SLC22A3
UniProt: O75751 (S22A3_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.59
Assay: Inhibition of human OCT3-mediated ASP+ uptake expressed in HEK293 cells after 3 mins by fluorescence assay
Drug: imatinib
Target: Platelet-derived growth factor receptor (Kinase)
Gene: PDGFRB|PDGFRA
UniProt: P09619|P16234 (PGFRB_HUMAN|PGFRA_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7.3
Assay: Inhibition of the platelet-derived growth factor receptor.
Drug: imatinib
Target: Tyrosine-protein kinase ABL (Kinase)
Gene: ABL1|ABL2
UniProt: P00519|P42684 (ABL1_HUMAN|ABL2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7.4
Assay: Inhibition of Abl tyrosine kinase
Drug: imatinib
Target: Bcr/Abl fusion protein (Kinase)
Gene: ABL1|BCR
UniProt: P00519|P11274 (ABL1_HUMAN|BCR_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.85
Assay: Inhibition of Bcr-Abl
Drug: imatinib
Target: Platelet-derived growth factor receptor beta (Kinase)
Gene: Pdgfrb
UniProt: Q05030 (PGFRB_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 6.79
Assay: Inhibition of PDGFR-beta driven proliferation of rat A10 cells after 68 hrs in presence of rat recombinant PDGF-BB by cell titer-glo luminescence assay
Drug: imidapril
Target: Angiotensin-converting enzyme (Enzyme)
Gene: ACE
UniProt: P12821 (ACE_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5
Action type: INHIBITOR
Assay: Inhibitory activity on Angiotensin I converting enzyme (ACE) obtained from pig renal cortex and hippuryl-histidyl-leucine as substrate
Drug: imipenem
Target: Penicillin-binding protein 4 (Enzyme)
UniProt: Q5D1E9 (Q5D1E9_STAAU)
Organism: Staphylococcus aureus
Activity: IC50 = 7.3
Drug: imipenem
Target: Penicillin-binding protein 1 (Enzyme)
Gene: ponA
UniProt: A1KS91 (A1KS91_NEIMF)
Organism: Neisseria meningitidis serogroup C / serotype 2a (strain ATCC 700532 / DSM 15464 / FAM18)
Activity: IC50 = 7
Drug: imipenem
Target: Beta-lactamase (Enzyme)
Gene: blaPER-2
UniProt: A2RP81 (A2RP81_CITFR)
Organism: Citrobacter freundii
Activity: Ki = 7.22
Assay: Inhibition of Citrobacter freundii PER2 beta lactamase
Drug: imipenem
Target: Beta-lactamase GES-13 (Enzyme)
Gene: blaGES-13
UniProt: D1MIX9 (D1MIX9_PSEAI)
Organism: Pseudomonas aeruginosa
Activity: IC50 = 6.82
Assay: Inhibition of Pseudomonas aeruginosa GES-13 beta lactamase