AIM-Harvard/TrialPanorama-filtered huggingface dataset:
Drug: tamsulosin
Target: 5-hydroxytryptamine receptor 1A (GPCR)
Gene: HTR1A
UniProt: P08908 (5HT1A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 9.1
Assay: Binding affinity towards recombinant human Compound at 1 uM was tested for the inhibition of radioligand [3H]8-OH-DPAT binding to recombinant human 5-hydroxytryptamine 1A receptor was determined using [3H]8-OH-DPAT as radioligand
Drug: tamsulosin
Target: 5-hydroxytryptamine receptor 7 (GPCR)
Gene: HTR7
UniProt: P34969 (5HT7R_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.08
Assay: Binding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligand
Drug: tamsulosin
Target: Alpha-1A adrenergic receptor (GPCR)
Gene: ADRA1A
UniProt: P35348 (ADA1A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 10.54
Assay: Binding affinity against human adrenergic receptor subtype Alpha-1A adrenergic receptor using [3H]prazosin as radioligand
Drug: tamsulosin
Target: D(3) dopamine receptor (GPCR)
Gene: DRD3
UniProt: P35462 (DRD3_HUMAN)
Organism: Homo sapiens
Activity: Ki = 9.55
Assay: Binding affinity towards recombinant human Dopamine receptor D3 was determined using [3H]spiperone as radioligand
Drug: tamsulosin
Target: Alpha-2C adrenergic receptor (GPCR)
Gene: ADRA2C
UniProt: P18825 (ADA2C_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.1
Assay: Binding affinity against human Alpha-2C adrenergic receptor using [3H]rauwolscine as radioligand
Drug: tamsulosin
Target: Alpha-1D adrenergic receptor (GPCR)
Gene: ADRA1D
UniProt: P25100 (ADA1D_HUMAN)
Organism: Homo sapiens
Activity: Ki = 10.24
Assay: Binding affinity against human adrenergic receptor subtype Alpha-1D adrenergic receptor using [3H]prazosin as radioligand
Drug: tamsulosin
Target: Alpha-1B adrenergic receptor (GPCR)
Gene: ADRA1B
UniProt: P35368 (ADA1B_HUMAN)
Organism: Homo sapiens
Activity: Ki = 9.21
Assay: Binding affinity against human adrenergic receptor subtype Alpha-1B adrenergic receptor using [3H]prazosin as radioligand
Drug: tamsulosin
Target: Alpha-1A adrenergic receptor (GPCR)
Gene: Adra1a
UniProt: P43140 (ADA1A_RAT)
Organism: Rattus norvegicus
Activity: Ki = 10.52
Assay: In vitro binding affinity using [3H]prazosin as radioligand against adrenoceptor alpha 1A
Drug: tamsulosin
Target: Alpha-2B adrenergic receptor (GPCR)
Gene: Adra2b
UniProt: P19328 (ADA2B_RAT)
Organism: Rattus norvegicus
Activity: Ki = 8.17
Assay: Binding affinity against rat Alpha-2B adrenergic receptor using [3H]rauwolscine as radioligand
Drug: tamsulosin
Target: Alpha-1D adrenergic receptor (GPCR)
Gene: Adra1d
UniProt: P23944 (ADA1D_RAT)
Organism: Rattus norvegicus
Activity: Ki = 10.15
Assay: In vitro binding affinity using [3H]prazosin as radioligand against adrenoceptor alpha 1d expressed in LTK cell
Drug: tamsulosin
Target: Alpha-1A adrenergic receptor (GPCR)
Gene: ADRA1A
UniProt: P18130 (ADA1A_BOVIN)
Organism: Bos taurus
Activity: Ki = 9.9
Drug: tamsulosin
Target: Alpha-1B adrenergic receptor (GPCR)
Gene: ADRA1B
UniProt: P18841 (ADA1B_MESAU)
Organism: Mesocricetus auratus
Activity: Ki = 9.7
Assay: In vitro binding affinity using [3H]prazosin as radioligand against adrenoceptor alpha 1b expressed in LTK cell
Drug: tamsulosin
Target: Serotonin 1 (5-HT1) receptor (GPCR)
Gene: Htr1a|Htr1b|Htr1d|Htr1f
UniProt: P19327|P28564|P28565|P30940 (5HT1A_RAT|5HT1B_RAT|5HT1D_RAT|5HT1F_RAT)
Organism: Rattus norvegicus
Activity: Ki = 6.03
Assay: Binding affinity towards 5-hydroxytryptamine 1 receptor was determined in rat cerebral cortex using [3H]5-HT as radioligand
Drug: tandospirone
Target: D(2) dopamine receptor (GPCR)
Gene: DRD2
UniProt: P14416 (DRD2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.55
Assay: Binding affinity for DA2 receptor
Drug: tandospirone
Target: 5-hydroxytryptamine receptor 1A (GPCR)
Gene: HTR1A
UniProt: P08908 (5HT1A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.49
Assay: Binding affinity to 5-hydroxytryptamine 1A receptor was determined
Drug: tandospirone
Target: D(4) dopamine receptor (GPCR)
Gene: DRD4
UniProt: P21917 (DRD4_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.14
Assay: Binding affinity to Dopamine receptor D4 was determined
Drug: tazarotene
Target: Retinoic acid receptor alpha (Nuclear hormone receptor)
Gene: RARA
UniProt: P10276 (RARA_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 7.2
Action type: AGONIST
Assay: Activity at human RARalpha ligand binding domain expressed in COS7 cells co-transfected with Gal4-DBD assessed as transcriptional activation after 16 hrs by Gal4 response element-driven luciferase reporter gene assay
Drug: tazarotene
Target: Retinoic acid receptor beta (Nuclear hormone receptor)
Gene: RARB
UniProt: P10826 (RARB_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 9.1
Action type: AGONIST
Assay: Activity at human RARbeta ligand binding domain expressed in COS7 cells co-transfected with Gal4-DBD assessed as transcriptional activation after 16 hrs by Gal4 response element-driven luciferase reporter gene assay
Drug: tazarotene
Target: Retinoic acid receptor gamma (Nuclear hormone receptor)
Gene: RARG
UniProt: P13631 (RARG_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 7.4
Action type: AGONIST
Assay: Activity at human RARgamma ligand binding domain expressed in COS7 cells co-transfected with Gal4-DBD assessed as transcriptional activation after 16 hrs by Gal4 response element-driven luciferase reporter gene assay
Drug: tazobactam
Target: Beta-lactamase (Enzyme)
Gene: penP
UniProt: P00808 (BLAC_BACLI)
Organism: Bacillus licheniformis
Activity: IC50 = 6.29
Assay: Compound was tested for inhibition of Beta-lactamase from Bacillus licheniformis 749/C
Drug: tazobactam
Target: Beta-lactamase (Enzyme)
Gene: blaZ
UniProt: P00807 (BLAC_STAAU)
Organism: Staphylococcus aureus
Activity: IC50 = 6.527
Drug: tazobactam
Target: Beta-lactamase TEM (Enzyme)
Gene: bla; blaT-3; blaT-4;
UniProt: P62593 (BLAT_ECOLX)
Organism: Escherichia coli
Activity: IC50 = 6.602
Action type: INHIBITOR
Drug: tazobactam
Target: Beta-lactamase (Enzyme)
Gene: ampC
UniProt: P00811 (AMPC_ECOLI)
Organism: Escherichia coli (strain K12)
Activity: IC50 = 7.824
Drug: tazobactam
Target: Beta-lactamase (Enzyme)
UniProt: Q59401 (Q59401_ENTCL)
Organism: Enterobacter cloacae
Activity: IC50 = 5.47
Assay: The compound was evaluated for inhibition against the GC1 extended spectrum Class C beta-lactamase
Drug: tazobactam
Target: Beta-lactamase SHV-1 (Enzyme)
Gene: bla
UniProt: P0AD63 (BLA1_ECOLX)
Organism: Escherichia coli
Activity: IC50 = 6.65
Assay: Inhibition of Escherichia coli SHV1
Drug: tazobactam
Target: Beta-lactamase 1 (Enzyme)
Gene: penPC
UniProt: P10424 (BLA1_BACCE)
Organism: Bacillus cereus
Activity: IC50 = 6.524
Assay: DRUGMATRIX: beta-Lactamase enzyme inhibition (substrate: Nitrocefin)
Drug: tazobactam
Target: IMI-1; IMI-1 carbapenemase (Enzyme)
Gene: imiA
UniProt: Q46991 (Q46991_ENTCL)
Organism: Enterobacter cloacae
Activity: IC50 = 7.52
Assay: In vitro inhibitory activity against Class A (Imi-1) beta-Lactamases
Drug: tazobactam
Target: Beta-lactamase (Enzyme)
Gene: ampC
UniProt: P05364 (AMPC_ENTCL)
Organism: Enterobacter cloacae
Activity: IC50 = 7
Assay: In vitro inhibitory activity against Beta-lactamase TEM-1 of class A enzyme
Drug: tazobactam
Target: Beta-lactamase (Enzyme)
Gene: blaTEM-1
UniProt: Q6W9J1 (Q6W9J1_ENTCL)
Organism: Enterobacter cloacae
Activity: IC50 = 7.22
Assay: Inhibitory activity against class A Beta-lactamase TEM isolated from Enterobacter coli
Drug: tazobactam
Target: Beta-lactamase (Enzyme)
Gene: ampC
UniProt: P24735 (AMPC_PSEAE)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Activity: IC50 = 6.09
Assay: Compound was tested for inhibition of Beta-lactamase from Pseudomonas aeruginosa 18SH
Drug: tazobactam
Target: Beta-lactamase (Enzyme)
Gene: ampC
UniProt: P94958 (AMPC_MORMO)
Organism: Morganella morganii
Activity: IC50 = 6.72
Assay: Compound was tested for inhibition of beta-Lactamases from Morganell morgani U1627
Drug: tazobactam
Target: Beta-lactamase (Enzyme)
Gene: ampC
UniProt: P05193 (AMPC_CITFR)
Organism: Citrobacter freundii
Activity: IC50 = 6.03
Assay: Compound was tested for inhibition of Beta-lactamase from Citrobacter freundii 1982
Drug: tazobactam
Target: Beta-lactamase (Enzyme)
Gene: BlaGIL-1
UniProt: A4KCT8 (A4KCT8_9ENTR)
Organism: Citrobacter gillenii
Activity: IC50 = 7.4
Assay: Inhibition of Citrobacter gillenii CIP 106783 Beta-lactamase GIL1 expressed in Escherichia coli DH10B
Drug: tazobactam
Target: Beta-lactamase (Enzyme)
Gene: blaSCO-1
UniProt: A1E3K9 (A1E3K9_ECOLX)
Organism: Escherichia coli
Activity: IC50 = 8
Assay: Inhibition of Escherichia coli beta-lactamase SCO1
Drug: tazobactam
Target: Beta-lactamase (Enzyme)
Gene: bcl1
UniProt: A8RR46 (A8RR46_BACCS)
Organism: Bacillus clausii
Activity: IC50 = 8.4
Assay: Inhibition of Bacillus clausii NR beta-lactamase BCL1 expressed in Escherichia coli BL21 (DE3)
Drug: tazobactam
Target: Carbapenem-hydrolizing beta-lactamase SFC-1 (Enzyme)
UniProt: Q6JP75 (Q6JP75_SERFO)
Organism: Serratia fonticola
Activity: IC50 = 5.16
Assay: Inhibition of Serratia fonticola UTAD54 SFC1 beta lactamase expressed in Escherichia coli BL21(DE3) by SDS-PAGE
Drug: tazobactam
Target: Carbepenem-hydrolyzing beta-lactamase KPC (Enzyme)
Gene: bla
UniProt: Q9F663 (BLKPC_KLEPN)
Organism: Klebsiella pneumoniae
Activity: Ki = 4.13
Assay: Inhibition of Klebsiella pneumoniae 1534 beta-lactamase KPC-2 by competitive assay
Drug: tazobactam
Target: Beta-lactamase (Enzyme)
Gene: blaPER-2
UniProt: A2RP81 (A2RP81_CITFR)
Organism: Citrobacter freundii
Activity: IC50 = 7.02
Assay: Inhibition of Citrobacter freundii PER2 beta lactamase
Drug: tazobactam
Target: Beta-lactamase (Enzyme)
Gene: blaUOE-1
UniProt: Q9EXV5 (Q9EXV5_ECOLX)
Organism: Escherichia coli
Activity: IC50 = 8.7
Assay: Inhibition of Escherichia coli CTX-M-15
Drug: tazobactam
Target: Beta-lactamase SHV-1 (Enzyme)
Gene: bla
UniProt: P0AD64 (BLA1_KLEPN)
Organism: Klebsiella pneumoniae
Activity: IC50 = 6.96
Assay: Inhibition of Klebsiella pneumoniae Beta-Lactamase SHV-1
Drug: tazobactam
Target: Beta-lactamase (Enzyme)
Gene: blaTEM-125
UniProt: Q6GWS8 (Q6GWS8_ECOLX)
Organism: Escherichia coli
Activity: IC50 = 6.62
Assay: Inhibition of Escherichia coli DH5alpha beta-lactamase TEM-158
Drug: tazobactam
Target: Beta-lactamase GES-13 (Enzyme)
Gene: blaGES-13
UniProt: D1MIX9 (D1MIX9_PSEAI)
Organism: Pseudomonas aeruginosa
Activity: IC50 = 7.22
Assay: Inhibition of Pseudomonas aeruginosa GES-13 beta lactamase
Drug: tazobactam
Target: Beta-lactamase (Enzyme)
Gene: blaSHV-72
UniProt: A0ZX81 (A0ZX81_KLEPN)
Organism: Klebsiella pneumoniae
Activity: IC50 = 7.1
Assay: Inhibition of Klebsiella pneumoniae Beta-Lactamase SHV-72
Drug: tazobactam
Target: Class D beta-lactamase (Unclassified)
Gene: oxa-63
UniProt: Q50H31 (Q50H31_BRAPL)
Organism: Brachyspira pilosicoli
Activity: IC50 = 6.8
Assay: Inhibition of Brachyspira pilosicoli beta-lactamase OXA-63 expressed in Escherichia coli BL21 (DE3) assessed as reduction in nitrocefin hydrolysis by spectrophotometry relative to oxacillin
Drug: tazobactam
Target: Beta-lactamase (Enzyme)
Gene: penB1
UniProt: B8R6A5 (B8R6A5_9BURK)
Organism: Burkholderia cenocepacia
Activity: IC50 = 6.3
Assay: Inhibition of Burkholderia cenocepacia 07-34 beta-lactamase PenB1
Drug: tazobactam
Target: Beta-lactamase (Enzyme)
Gene: blaCTX-M-53
UniProt: Q2XPY6 (Q2XPY6_SALET)
Organism: Salmonella enterica subsp. enterica serovar Westhampton
Activity: IC50 = 8.66
Assay: Inhibition of Salmonella enterica serotype Westhampton beta-lactamase CTX-M-53
Drug: tazobactam
Target: Beta-lactamase (Enzyme)
UniProt: D2SSQ3 (D2SSQ3_PSEAI)
Organism: Pseudomonas aeruginosa
Activity: IC50 = 5.7
Assay: Inhibition of Pseudomonas aeruginosa 531 beta-lactamase BEL-2
Drug: tazobactam
Target: Beta-lactamase (Enzyme)
Gene: bla(BEL1)
UniProt: Q3SAW3 (Q3SAW3_PSEAI)
Organism: Pseudomonas aeruginosa
Activity: IC50 = 5.7
Assay: Inhibition of Pseudomonas aeruginosa 51170 beta-lactamase BEL-1
Drug: tazobactam
Target: Beta-lactamase (Enzyme)
UniProt: Q670S6 (Q670S6_PSELU)
Organism: Pseudomonas luteola
Activity: IC50 = 7.4
Assay: Inhibition of Pseudomonas luteola LAM Beta-lactamase LUT-1
Drug: tegaserod
Target: 5-hydroxytryptamine receptor 4 (GPCR)
Gene: HTR4
UniProt: O70528 (5HT4R_CAVPO)
Organism: Cavia porcellus
Activity: EC50 = 7.9
Assay: Induction of 5-HT4 receptor-mediated contraction in guinea pig longitudinal muscle myenteric plexus
Drug: tegaserod
Target: 5-hydroxytryptamine receptor 1A (GPCR)
Gene: HTR1A
UniProt: P08908 (5HT1A_HUMAN)
Organism: Homo sapiens
Drug: tegaserod
Target: 5-hydroxytryptamine receptor 2B (GPCR)
Gene: HTR2B
UniProt: P41595 (5HT2B_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.4
Action type: ANTAGONIST
Drug: tegaserod
Target: 5-hydroxytryptamine receptor 1D (GPCR)
Gene: HTR1D
UniProt: P28221 (5HT1D_HUMAN)
Organism: Homo sapiens
Drug: tegaserod
Target: 5-hydroxytryptamine receptor 3A (Ion channel)
Gene: HTR3A
UniProt: P46098 (5HT3A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.6
Assay: Binding affinity to human recombinant 5HT3 receptor
Drug: tegaserod
Target: 5-hydroxytryptamine receptor 4 (GPCR)
Gene: HTR4
UniProt: Q13639 (5HT4R_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.4
Action type: PARTIAL AGONIST
Assay: Binding affinity at 5HT4 receptor
Drug: teicoplanin aglycone
Target: Cathepsin L1 (Enzyme)
Gene: CTSL
UniProt: P07711 (CATL1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.78
Action type: INHIBITOR
Assay: Teicoplanin potently prevents the entrance of 2019-nCoV-Spike-pseudoviruses into the cytoplasm
Drug: telithromycin
Target: Potassium voltage-gated channel subfamily H member 2 (Ion channel)
Gene: KCNH2
UniProt: Q12809 (KCNH2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.4
Assay: Inhibition of human ERG by patch-clamp assay
Drug: telmisartan
Target: Angiotensin-converting enzyme (Enzyme)
Gene: ACE
UniProt: P12821 (ACE_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.22
Assay: Inhibition of ACE (unknown origin) assessed as 3-Hydroxybutyril-glycil-glycil-glycine conversion to 3-hydroxybutyric acid after 60 mins by WST assay
Drug: telmisartan
Target: Glycine receptor subunit alpha-1 (Ion channel)
Gene: GLRA1
UniProt: P23415 (GLRA1_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 5.49
Drug: telmisartan
Target: Type-1 angiotensin II receptor (GPCR)
Gene: AGTR1
UniProt: P30556 (AGTR1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 9.31
Action type: ANTAGONIST
Assay: Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation counting
Drug: telmisartan
Target: Peroxisome proliferator-activated receptor gamma (Nuclear hormone receptor)
Gene: PPARG
UniProt: P37231 (PPARG_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 5.82
Assay: Partial agonist activity at human PPARgamma-LBD/Gal4 DNA binding domain by transactivation assay
Drug: telmisartan
Target: Type-2 angiotensin II receptor (GPCR)
Gene: AGTR2
UniProt: P50052 (AGTR2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 9.48
Assay: Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
Drug: telmisartan
Target: Type-1B angiotensin II receptor (GPCR)
Gene: Agtr1b
UniProt: P29089 (AGTRB_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 8.52
Assay: Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
Drug: telmisartan
Target: Type-1A angiotensin II receptor (GPCR)
Gene: Agtr1
UniProt: P25095 (AGTRA_RAT)
Organism: Rattus norvegicus
Activity: Ki = 9.64
Assay: Displacement of [125I]SI-Ang2 from AT1 receptor in Sprague-Dawley rat liver membrane
Drug: telmisartan
Target: Multidrug and toxin extrusion protein 1 (Transporter)
Gene: SLC47A1
UniProt: Q96FL8 (S47A1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.75
Assay: Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay
Drug: temazepam
Target: Nuclear receptor subfamily 1 group I member 3 (Nuclear hormone receptor)
Gene: NR1I3
UniProt: Q14994 (NR1I3_HUMAN)
Organism: Homo sapiens
Drug: temazepam
Target: GABA-A receptor alpha-1/beta-2/gamma-2 (Ion channel)
Gene: GABRA1|GABRG2|GABRB2
UniProt: P14867|P18507|P47870 (GBRA1_HUMAN|GBRG2_HUMAN|GBRB2_HUMAN)
Organism: Homo sapiens
Action type: POSITIVE ALLOSTERIC MODULATOR
Drug: temocapril
Target: Angiotensin-converting enzyme (Enzyme)
Gene: ACE
UniProt: P12822 (ACE_RABIT)
Organism: Oryctolagus cuniculus
Activity: IC50 = 8.444
Action type: INHIBITOR
Drug: temocapril
Target: Angiotensin-converting enzyme (Enzyme)
Gene: ACE
UniProt: P12821 (ACE_HUMAN)
Organism: Homo sapiens
Action type: INHIBITOR
Assay: Mechanism of Action
Drug: teniposide
Target: Multidrug resistance protein 1 (Transporter)
Gene: ABCB1
UniProt: P08183 (MDR1_HUMAN)
Organism: Homo sapiens
Drug: teniposide
Target: DNA topoisomerase 2-alpha (Enzyme)
Gene: TOP2A
UniProt: P11388 (TOP2A_HUMAN)
Organism: Homo sapiens
Action type: INHIBITOR
Assay: Mechanism of Action; CHEMBL2094255; PROTEIN FAMILY
Drug: teniposide
Target: ATP-binding cassette sub-family G member 2 (Transporter)
Gene: ABCG2
UniProt: Q9UNQ0 (ABCG2_HUMAN)
Organism: Homo sapiens
Drug: teniposide
Target: Multidrug resistance-associated protein 6 (Transporter)
Gene: ABCC6
UniProt: O95255 (MRP6_HUMAN)
Organism: Homo sapiens
Drug: teniposide
Target: Canalicular multispecific organic anion transporter 2 (Transporter)
Gene: ABCC3
UniProt: O15438 (MRP3_HUMAN)
Organism: Homo sapiens
Drug: tenofovir
Target: Reverse transcriptase (Enzyme)
Gene: reverse transcriptas
UniProt: Q9WKE8 (Q9WKE8_9HIV1)
Organism: Human immunodeficiency virus 1
Activity: IC50 = 6.42
Assay: Inhibition of HIV1 reverse transcriptase
Drug: tenofovir
Target: Capsid protein (Unclassified)
Gene: HBcAg
UniProt: Q03732 (Q03732_HBV)
Organism: Hepatitis B virus
Activity: EC50 = 6.62
Assay: Inhibition of hepatitis B virus capsid assembly infected in human HepG2.215 cells assessed as reduction in viral DNA replication measured on day 7 by real time PCR analysis
Drug: tenofovir disoproxil
Target: Gag-Pol polyprotein (Polyprotein)
Gene: gag-pol
UniProt: P03369 (POL_HV1A2)
Organism: Human immunodeficiency virus type 1 group M subtype B (isolate ARV2/SF2)
Drug: tenofovir disoproxil
Target: Reverse transcriptase/RNaseH (Enzyme)
Gene: pol
UniProt: Q72547 (Q72547_9HIV1)
Organism: Human immunodeficiency virus 1
Action type: INHIBITOR
Assay: Mechanism of Action; CHEMBL247; SINGLE PROTEIN
Drug: tenoxicam
Target: Prostaglandin G/H synthase 2 (Enzyme)
Gene: PTGS2
UniProt: P35354 (PGH2_HUMAN)
Organism: Homo sapiens
Drug: tenoxicam
Target: Prostaglandin G/H synthase 1 (Enzyme)
Gene: PTGS1
UniProt: P23219 (PGH1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.943
Assay: DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid)
Drug: terbinafine
Target: Alpha-2A adrenergic receptor (GPCR)
Gene: ADRA2A
UniProt: P08913 (ADA2A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.67
Assay: DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)
Drug: terbinafine
Target: Sigma non-opioid intracellular receptor 1 (Membrane receptor)
Gene: SIGMAR1
UniProt: Q99720 (SGMR1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.628
Assay: DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol)
Drug: terbinafine
Target: Sodium-dependent noradrenaline transporter (Transporter)
Gene: SLC6A2
UniProt: P23975 (SC6A2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.388
Assay: DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55)
Drug: terbinafine
Target: Cytochrome P450 2D6 (Enzyme)
Gene: CYP2D6
UniProt: P10635 (CP2D6_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.699
Assay: DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)
Drug: terbinafine
Target: Squalene monooxygenase (Enzyme)
Gene: SQLE
UniProt: Q14534 (ERG1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.52
Assay: Inhibitory activity against Candida albicans Squalene Epoxidase
Drug: terbinafine
Target: Squalene epoxidase (Enzyme)
UniProt: Q4JEY0 (Q4JEY0_TRIRU)
Organism: Trichophyton rubrum
Action type: INHIBITOR
Assay: Mechanism of Action; CHEMBL2364679; SINGLE PROTEIN
Drug: terbinafine
Target: Membrane-associated progesterone receptor component 1 (Membrane receptor)
Gene: Pgrmc1
UniProt: P70580 (PGRC1_RAT)
Organism: Rattus norvegicus
Activity: Ki = 7.662
Assay: DRUGMATRIX: Sigma2 radioligand binding (ligand: [3H] Ifenprodil)
Drug: terbinafine
Target: Squalene monooxygenase (Enzyme)
Gene: Sqle
UniProt: P52020 (ERG1_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 4.03
Assay: Inhibitory activity against rat liver Squalene Epoxidase
Drug: terbutaline
Target: Beta-2 adrenergic receptor (GPCR)
Gene: ADRB2
UniProt: P07550 (ADRB2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.6
Action type: AGONIST
Drug: terbutaline
Target: Beta-2 adrenergic receptor (GPCR)
Gene: ADRB2
UniProt: Q28044 (ADRB2_BOVIN)
Organism: Bos taurus
Activity: Kd = 5.4
Assay: Affinity for cow beta-2 adrenergic receptor by measuring displacement (-)-[3H]dihydroalprenolol (DHA)
Drug: terconazole
Target: Sodium/nucleoside cotransporter 1 (Transporter)
Gene: SLC28A1
UniProt: O00337 (S28A1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.373
Assay: DRUGMATRIX: Sodium/nucleoside co-transporter radioligand binding (ligand: nitrobenzylthioinosine)
Drug: terconazole
Target: 5-hydroxytryptamine receptor 4 (GPCR)
Gene: HTR4
UniProt: O70528 (5HT4R_CAVPO)
Organism: Cavia porcellus
Activity: Ki = 5.609
Assay: DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT4 radioligand binding (ligand: [3H] GR-113808)
Drug: terconazole
Target: D(1A) dopamine receptor (GPCR)
Gene: DRD1
UniProt: P21728 (DRD1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 4.895
Assay: DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)
Drug: terconazole
Target: Alpha-2A adrenergic receptor (GPCR)
Gene: ADRA2A
UniProt: P08913 (ADA2A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.433
Assay: DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)
Drug: terconazole
Target: Sigma non-opioid intracellular receptor 1 (Membrane receptor)
Gene: SIGMAR1
UniProt: Q99720 (SGMR1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.67
Assay: DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol)
Drug: terconazole
Target: Sodium-dependent serotonin transporter (Transporter)
Gene: SLC6A4
UniProt: P31645 (SC6A4_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.216
Assay: DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine)
Drug: terconazole
Target: Sodium-dependent noradrenaline transporter (Transporter)
Gene: SLC6A2
UniProt: P23975 (SC6A2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 4.599
Assay: DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55)
Drug: terconazole
Target: 5-hydroxytryptamine receptor 2A (GPCR)
Gene: HTR2A
UniProt: P28223 (5HT2A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.632
Assay: DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin)
Drug: terconazole
Target: 5-hydroxytryptamine receptor 2C (GPCR)
Gene: HTR2C
UniProt: P28335 (5HT2C_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.438
Assay: DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine)
Drug: terconazole
Target: Alpha-2B adrenergic receptor (GPCR)
Gene: ADRA2B
UniProt: P18089 (ADA2B_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.904
Assay: DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug: terconazole
Target: D(3) dopamine receptor (GPCR)
Gene: DRD3
UniProt: P35462 (DRD3_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.796
Assay: DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone)
Drug: terconazole
Target: Muscarinic acetylcholine receptor M1 (GPCR)
Gene: CHRM1
UniProt: P11229 (ACM1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.862
Assay: DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine)
Drug: terconazole
Target: Muscarinic acetylcholine receptor M2 (GPCR)
Gene: CHRM2
UniProt: P08172 (ACM2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.338
Assay: DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)