AIM-Harvard/TrialPanorama-filtered huggingface dataset:
Drug: cyproheptadine
Target: Muscarinic acetylcholine receptor (GPCR)
Gene: Chrm1|Chrm3|Chrm4|Chrm5|Chrm2
UniProt: P08482|P08483|P08485|P08911|P10980 (ACM1_RAT|ACM3_RAT|ACM4_RAT|ACM5_RAT|ACM2_RAT)
Organism: Rattus norvegicus
Activity: Ki = 8.4
Assay: Displacement of [3H]- QNB binding at the muscarinic-cholinergic binding site of rat brain S1
Drug: cyproheptadine
Target: Dopamine receptor (GPCR)
Gene: Drd1|Drd3|Drd5|Drd4|Drd2
UniProt: P18901|P19020|P25115|P30729|P61169 (DRD1_RAT|DRD3_RAT|DRD5_RAT|DRD4_RAT|DRD2_RAT)
Organism: Rattus norvegicus
Activity: Ki = 7.2
Assay: Displacement of [3H]- spiperone radioligand binding at the dopamine binding site of rat caudate
Drug: cyproheptadine
Target: Sodium channel alpha subunits; brain (Types I, II, III) (Ion channel)
Gene: SCN1A|SCN2A|SCN3A
UniProt: P35498|Q99250|Q9NY46 (SCN1A_HUMAN|SCN2A_HUMAN|SCN3A_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6
Assay: Inhibition of binding of Batrachotoxinin [3H]BTX-B to high affinity sites on voltage dependent sodium channels in a vesicular preparation from guinea pig cerebral cortex
Drug: cyproheptadine
Target: Serotonin 2 (5-HT2) receptor (GPCR)
Gene: Htr2c|Htr2a|Htr2b
UniProt: P08909|P14842|P30994 (5HT2C_RAT|5HT2A_RAT|5HT2B_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 8.51
Assay: Binding affinity at serotonin 5-hydroxytryptamine 2 receptor by [3H]ketanserin displacement.
Drug: cyproheptadine
Target: Histone-lysine N-methyltransferase SETD7 (Enzyme)
Gene: SETD7
UniProt: Q8WTS6 (SETD7_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.7
Drug: cyproterone acetate
Target: Mu-type opioid receptor (GPCR)
Gene: OPRM1
UniProt: P35372 (OPRM_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.053
Assay: DRUGMATRIX: Opiate mu (OP3, MOP) radioligand binding (ligand: [3H] Diprenorphine)
Drug: cyproterone acetate
Target: Glucocorticoid receptor (Nuclear hormone receptor)
Gene: NR3C1
UniProt: P04150 (GCR_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7.796
Drug: cyproterone acetate
Target: Androgen receptor (Nuclear hormone receptor)
Gene: AR
UniProt: P10275 (ANDR_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7.432
Action type: ANTAGONIST
Drug: cyproterone acetate
Target: Progesterone receptor (Nuclear hormone receptor)
Gene: PGR
UniProt: P06401 (PRGR_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 9.678
Drug: cyproterone acetate
Target: Androgen receptor (Transcription factor)
Gene: Ar
UniProt: P15207 (ANDR_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 4.74
Drug: cyproterone acetate
Target: Progesterone receptor (Transcription factor)
Gene: PGR
UniProt: Q690N0 (Q690N0_BOVIN)
Organism: Bos taurus
Activity: Ki = 8.315
Assay: DRUGMATRIX: Progesterone radioligand binding (ligand: [3H] R-5020)
Drug: cyproterone acetate
Target: Adenosine receptor A1 (GPCR)
Gene: Adora1
UniProt: P25099 (AA1R_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 8.3
Drug: cysteine
Target: Cystine/glutamate transporter (Transporter)
Gene: SLC7A11
UniProt: Q9UPY5 (XCT_HUMAN)
Organism: Homo sapiens
Activity: Ki = 4.23
Assay: Competitive inhibition of [3H]L-glutamate uptake at amino acid transport system xc- in human SNB19 cells by liquid scintillation counting
Drug: cytarabine
Target: Prostatic acid phosphatase (Enzyme)
Gene: ACPP
UniProt: P15309 (PPAP_HUMAN)
Organism: Homo sapiens
Activity: GI50 = 7
Drug: cytarabine
Target: Enoyl-[acyl-carrier-protein] reductase [NADH] (Enzyme)
Gene: fabI
UniProt: Q5NGQ3 (Q5NGQ3_FRATT)
Organism: Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4)
Activity: IC50 = 4.23
Assay: Inhibition of C-terminal His6-tagged Francisella tularensis SCHU S4 FabI expressed in Escherichia coli BL21 (DE3) using CrCoA as substrate assessed as oxidation of NADH to NAD+ by fluorescence assay
Drug: cytarabine
Target: DNA polymerase beta (Enzyme)
Gene: POLB
UniProt: P06746 (DPOLB_HUMAN)
Organism: Homo sapiens
Drug: cytarabine
Target: DNA polymerase (alpha/delta/epsilon) (Enzyme)
Gene: POLA1|POLD1|POLE
UniProt: P09884|P28340|Q07864 (DPOLA_HUMAN|DPOD1_HUMAN|DPOE1_HUMAN)
Organism: Homo sapiens
Action type: INHIBITOR
Assay: Mechanism of Action; CHEMBL2363042; PROTEIN FAMILY
Drug: cytarabine
Target: E3 ubiquitin-protein ligase Mdm2 (Nuclear other)
Gene: MDM2
UniProt: Q00987 (MDM2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7.7
Assay: Inhibition of MDM2 (unknown origin)
Drug: dacarbazine
Target: Matrix metalloproteinase-9 (Enzyme)
Gene: MMP9
UniProt: P14780 (MMP9_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.255
Assay: DRUGMATRIX: Protease, Matrix Metalloprotease-9 (MMP-9) enzyme inhibition (substrate: Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2)
Drug: dacarbazine
Target: DNA polymerase alpha subunit B (Enzyme)
Gene: POLA2
UniProt: Q14181 (DPOA2_HUMAN)
Organism: Homo sapiens
Drug: dactinomycin
Target: Growth factor receptor-bound protein 2 (Cytosolic other)
Gene: GRB2
UniProt: P62993 (GRB2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.3
Assay: Inhibition of GST-Grb2 Tyrosine kinase SH2 domain binding to [3H]labeled-phosphopeptide (Ac-SpYVNK-NH-C(O)-CH2CH2H3)
Drug: dactinomycin
Target: Discoidin domain-containing receptor 2 (Kinase)
Gene: DDR2
UniProt: Q16832 (DDR2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.05
Drug: dactinomycin
Target: Growth factor receptor-bound protein 2 (Cytosolic other)
Gene: Grb2
UniProt: Q60631 (GRB2_MOUSE)
Organism: Mus musculus
Activity: IC50 = 5.3
Assay: In vitro binding assay of Shc-derived phosphopeptide to Growth factor receptor bound protein 2 SH2 in B104-1-1 cells was determined
Drug: dactinomycin
Target: Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase (Enzyme)
Gene: NGLY1
UniProt: Q96IV0 (NGLY1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 4.05
Assay: Binding affinity to recombinant hexa-histidine-tagged human full-length N-GLY1 catalytic domain expressed in Escherichia coli BL21 (DE3) by thermal shift assay
Drug: dabigatran etexilate
Target: Ribosyldihydronicotinamide dehydrogenase [quinone] (Enzyme)
Gene: NQO2
UniProt: P16083 (NQO2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.96
Assay: Displacement of (S)-N4-(4-(3-(2-((4-carbamimidoylphenylamino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanamido)butyl)-N1-(15-oxo-19-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-4,7,10-trioxa-14-azanonadecyl)-2-(4-(3-(trifluoromethyl)-3H-diazirin-3-yl)benzamido)succinamide from human recombinant NQO2 after 1 hr by densitometric analysis
Drug: dabigatran etexilate
Target: Plasminogen (Enzyme)
Gene: PLG
UniProt: P00747 (PLMN_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.77
Assay: Inhibitory constant (Ki) was determined against human plasmin
Drug: dabigatran etexilate
Target: Prothrombin (Enzyme)
Gene: F2
UniProt: P00734 (THRB_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.35
Action type: INHIBITOR
Assay: Binding affinity to human thrombin
Drug: dabigatran etexilate
Target: Coagulation factor X (Enzyme)
Gene: F10
UniProt: P00742 (FA10_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.42
Assay: Inhibitory constant (Ki) was determined against human Coagulation factor Xa (fXa)
Drug: dabigatran etexilate
Target: Tissue-type plasminogen activator (Enzyme)
Gene: PLAT
UniProt: P00750 (TPA_HUMAN)
Organism: Homo sapiens
Activity: Ki = 4.34
Assay: Inhibitory constant (Ki) was determined against human Tissue plasminogen activator (tissue plasminogen activator)
Drug: dabigatran etexilate
Target: Vitamin K-dependent protein C (Enzyme)
Gene: PROC
UniProt: P04070 (PROC_HUMAN)
Organism: Homo sapiens
Activity: Ki = 4.68
Assay: Inhibitory constant (Ki) was determined against human Activated protein C
Drug: dabigatran etexilate
Target: Solute carrier family 22 member 2 (Transporter)
Gene: SLC22A2
UniProt: O15244 (S22A2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.33
Assay: Inhibition of human OCT2-mediated ASP+ uptake expressed in HEK293 cells after 3 mins by fluorescence assay
Drug: dabigatran etexilate
Target: Multidrug and toxin extrusion protein 1 (Transporter)
Gene: SLC47A1
UniProt: Q96FL8 (S47A1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.09
Assay: Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay
Drug: dabigatran etexilate
Target: Multidrug and toxin extrusion protein 2 (Transporter)
Gene: SLC47A2
UniProt: Q86VL8 (S47A2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.6
Assay: Inhibition of human MATE2K-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay
Drug: dabigatran etexilate
Target: Trypsin (Enzyme)
Gene: PRSS1|PRSS2|PRSS3
UniProt: P07477|P07478|P35030 (TRY1_HUMAN|TRY2_HUMAN|TRY3_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.3
Assay: Inhibitory constant (Ki) was determined against human trypsin
Drug: dabigatran etexilate
Target: Serine protease hepsin (Enzyme)
Gene: HPN
UniProt: P05981 (HEPS_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.08
Drug: dabigatran etexilate
Target: Thrombin (Unclassified)
Gene: thrombin
UniProt: Q28731 (Q28731_RABIT)
Organism: Oryctolagus cuniculus
Activity: IC50 = 6.26
Assay: Inhibition of rabbit thrombin-induced platelet aggregation in rabbit platelet-rich plasma preincubated with rabbit liver microsomes for 4 hrs followed by addition to platelet
Drug: danazol
Target: Mu-type opioid receptor (GPCR)
Gene: OPRM1
UniProt: P35372 (OPRM_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.243
Assay: DRUGMATRIX: Opiate mu (OP3, MOP) radioligand binding (ligand: [3H] Diprenorphine)
Drug: danazol
Target: D(1A) dopamine receptor (GPCR)
Gene: DRD1
UniProt: P21728 (DRD1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 4.99
Assay: DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)
Drug: danazol
Target: Alpha-2A adrenergic receptor (GPCR)
Gene: ADRA2A
UniProt: P08913 (ADA2A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.163
Assay: DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)
Drug: danazol
Target: Sodium-dependent serotonin transporter (Transporter)
Gene: SLC6A4
UniProt: P31645 (SC6A4_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.087
Assay: DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine)
Drug: danazol
Target: Sodium-dependent noradrenaline transporter (Transporter)
Gene: SLC6A2
UniProt: P23975 (SC6A2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.248
Assay: DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55)
Drug: danazol
Target: 5-hydroxytryptamine receptor 2A (GPCR)
Gene: HTR2A
UniProt: P28223 (5HT2A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.597
Assay: DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin)
Drug: danazol
Target: Alpha-2B adrenergic receptor (GPCR)
Gene: ADRA2B
UniProt: P18089 (ADA2B_HUMAN)
Organism: Homo sapiens
Activity: Ki = 4.976
Assay: DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug: danazol
Target: D(3) dopamine receptor (GPCR)
Gene: DRD3
UniProt: P35462 (DRD3_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.009
Assay: DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone)
Drug: danazol
Target: Muscarinic acetylcholine receptor M3 (GPCR)
Gene: CHRM3
UniProt: P20309 (ACM3_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.425
Assay: DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)
Drug: danazol
Target: Glucocorticoid receptor (Nuclear hormone receptor)
Gene: NR3C1
UniProt: P04150 (GCR_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.708
Assay: DRUGMATRIX: Glucocorticoid radioligand binding (ligand: [3H] Dexamethasone)
Drug: danazol
Target: Beta-3 adrenergic receptor (GPCR)
Gene: ADRB3
UniProt: P13945 (ADRB3_HUMAN)
Organism: Homo sapiens
Activity: Ki = 4.894
Assay: DRUGMATRIX: Adrenergic beta3 radioligand binding (ligand: [125I] Cyanopindolol)
Drug: danazol
Target: Alpha-2C adrenergic receptor (GPCR)
Gene: ADRA2C
UniProt: P18825 (ADA2C_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.462
Assay: DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
Drug: danazol
Target: Sodium-dependent dopamine transporter (Transporter)
Gene: SLC6A3
UniProt: Q01959 (SC6A3_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.265
Assay: DRUGMATRIX: Dopamine Transporter radioligand binding (ligand: [125I] RTI-55)
Drug: danazol
Target: Adenosine receptor A3 (GPCR)
Gene: ADORA3
UniProt: P0DMS8 (AA3R_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.2
Assay: DRUGMATRIX: Adenosine A3 radioligand binding (ligand: AB-MECA)
Drug: danazol
Target: Kappa-type opioid receptor (GPCR)
Gene: OPRK1
UniProt: P41145 (OPRK_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.207
Assay: DRUGMATRIX: Opiate kappa (OP2, KOP) radioligand binding (ligand: [3H] Diprenorphine)
Drug: danazol
Target: Estrogen receptor (Nuclear hormone receptor)
Gene: ESR1
UniProt: P03372 (ESR1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.294
Assay: DRUGMATRIX: Estrogen ERalpha radioligand binding (ligand: [3H] Estradiol)
Drug: danazol
Target: Androgen receptor (Nuclear hormone receptor)
Gene: AR
UniProt: P10275 (ANDR_HUMAN)
Organism: Homo sapiens
Action type: AGONIST
Drug: danazol
Target: Progesterone receptor (Nuclear hormone receptor)
Gene: PGR
UniProt: P06401 (PRGR_HUMAN)
Organism: Homo sapiens
Action type: AGONIST
Drug: danazol
Target: Cytochrome P450 2C9 (Enzyme)
Gene: CYP2C9
UniProt: P11712 (CP2C9_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.523
Assay: DRUGMATRIX: CYP450, 2C9 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)
Drug: danazol
Target: Steryl-sulfatase (Enzyme)
Gene: STS
UniProt: P08842 (STS_HUMAN)
Organism: Homo sapiens
Drug: danazol
Target: Sex hormone-binding globulin (Secreted)
Gene: SHBG
UniProt: P04278 (SHBG_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.2
Assay: Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulin
Drug: danazol
Target: Substance-K receptor (GPCR)
Gene: TACR2
UniProt: P21452 (NK2R_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.053
Assay: DRUGMATRIX: Tachykinin NK2  radioligand binding (ligand: [3H] SR-48968)
Drug: danazol
Target: Androgen receptor (Transcription factor)
Gene: Ar
UniProt: P15207 (ANDR_RAT)
Organism: Rattus norvegicus
Activity: Ki = 8.097
Assay: DRUGMATRIX: Androgen (Testosterone) AR radioligand binding (ligand: [3H] Mibolerone)
Drug: danazol
Target: Progesterone receptor (Transcription factor)
Gene: PGR
UniProt: Q690N0 (Q690N0_BOVIN)
Organism: Bos taurus
Activity: Ki = 7.469
Assay: DRUGMATRIX: Progesterone radioligand binding (ligand: [3H] R-5020)
Drug: dantrolene
Target: Ryanodine receptor 1 (Ion channel)
Gene: RYR1
UniProt: P21817 (RYR1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.757
Action type: ANTAGONIST
Drug: dantrolene
Target: Ryanodine receptor 3 (Ion channel)
Gene: RYR3
UniProt: Q15413 (RYR3_HUMAN)
Organism: Homo sapiens
Action type: ANTAGONIST
Assay: Mechanism of Action; CHEMBL2062; SINGLE PROTEIN
Drug: dantrolene
Target: CDGSH iron-sulfur domain-containing protein 1 (Unclassified)
Gene: CISD1
UniProt: Q9NZ45 (CISD1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.68
Assay: Displacement of [3H]rosiglitazone from recombinant human C-terminal His-tagged MitoNEET cytosolic domain (32 to 108 residues) expressed in Escherichia coli BL21 by Cheng-Prusoff analysis
Drug: dapiprazole
Target: 5-hydroxytryptamine receptor 1A (GPCR)
Gene: HTR1A
UniProt: P08908 (5HT1A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.929
Assay: DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1A radioligand binding (ligand: [3H] 8-OH-DPAT)
Drug: dapiprazole
Target: 5-hydroxytryptamine receptor 2A (GPCR)
Gene: HTR2A
UniProt: P28223 (5HT2A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.762
Assay: DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin)
Drug: dapiprazole
Target: 5-hydroxytryptamine receptor 2B (GPCR)
Gene: HTR2B
UniProt: P41595 (5HT2B_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.173
Assay: DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
Drug: dapiprazole
Target: 5-hydroxytryptamine receptor 2C (GPCR)
Gene: HTR2C
UniProt: P28335 (5HT2C_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.485
Assay: DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine)
Drug: dapiprazole
Target: Alpha-1A adrenergic receptor (GPCR)
Gene: ADRA1A
UniProt: P35348 (ADA1A_HUMAN)
Organism: Homo sapiens
Action type: ANTAGONIST
Drug: dapiprazole
Target: Alpha-2B adrenergic receptor (GPCR)
Gene: ADRA2B
UniProt: P18089 (ADA2B_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.279
Assay: DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug: dapiprazole
Target: Alpha-1D adrenergic receptor (GPCR)
Gene: ADRA1D
UniProt: P25100 (ADA1D_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.388
Action type: ANTAGONIST
Assay: DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug: dapiprazole
Target: Alpha-1B adrenergic receptor (GPCR)
Gene: ADRA1B
UniProt: P35368 (ADA1B_HUMAN)
Organism: Homo sapiens
Drug: dapiprazole
Target: Alpha-1B adrenergic receptor (GPCR)
Gene: Adra1b
UniProt: P15823 (ADA1B_RAT)
Organism: Rattus norvegicus
Activity: Ki = 7.523
Assay: DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
Drug: dapiprazole
Target: Alpha-1A adrenergic receptor (GPCR)
Gene: Adra1a
UniProt: P43140 (ADA1A_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 7.02
Drug: dapiprazole
Target: 5-hydroxytryptamine receptor 1A (GPCR)
Gene: Htr1a
UniProt: P19327 (5HT1A_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 5.69
Drug: dapsone
Target: Cytochrome P450 3A4 (Enzyme)
Gene: CYP3A4
UniProt: P08684 (CP3A4_HUMAN)
Organism: Homo sapiens
Activity: Ki = 4.57
Drug: dapsone
Target: 5-hydroxytryptamine receptor 6 (GPCR)
Gene: HTR6
UniProt: P50406 (5HT6R_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.74
Assay: Antagonist activity at recombinant human 5-HT6 receptor expressed in HEK293 cells assessed as 5-HT-induced intracellular cAMP production after 30 mins
Drug: dapsone
Target: Dihydropteroate synthase 1 (Enzyme)
Gene: folP1
UniProt: P0C0X1 (DHPS1_MYCLE)
Organism: Mycobacterium leprae (strain TN)
Activity: IC50 = 5.9
Action type: INHIBITOR
Drug: dapsone
Target: Dihydrofolate reductase (Enzyme)
UniProt: P16184 (DYR_PNECA)
Organism: Pneumocystis carinii
Activity: IC50 = 5.82
Assay: Inhibitory activity was determined against dihydrofolate reductase in Pneumocystis carinii.
Drug: dapsone
Target: Myeloperoxidase (Enzyme)
Gene: MPO
UniProt: P05164 (PERM_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.38
Assay: Inhibition of MPO (unknown origin)
Drug: dapsone
Target: Glucose-6-phosphate 1-dehydrogenase (Enzyme)
Gene: G6PD
UniProt: P11413 (G6PD_HUMAN)
Organism: Homo sapiens
Drug: dapsone
Target: Dihydropteroate synthetase, putative (Unclassified)
UniProt: Q4Z710 (Q4Z710_PLABA)
Organism: Plasmodium berghei (strain Anka)
Activity: IC50 = 4.91
Assay: Inhibitory activity against dihydropteroic acid synthase (SYN) from Plasmodium berghei
Drug: dapsone
Target: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase (Unclassified)
Gene: PPPK-DHPS
UniProt: A0A113T0T6 (A0A113T0T6_PLABE)
Organism: Plasmodium berghei
Activity: IC50 = 4.91
Assay: Inhibitory activity against dihydropteroic acid synthase (SYN) from Plasmodium berghei
Drug: daptomycin
Target: Outer membrane porin protein OmpD (Transporter)
Gene: ompD
UniProt: Q57P83 (OMPD_SALCH)
Organism: Salmonella choleraesuis (strain SC-B67)
Drug: darifenacin
Target: Beta-1 adrenergic receptor (GPCR)
Gene: ADRB1
UniProt: P08588 (ADRB1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.5
Drug: darifenacin
Target: Beta-2 adrenergic receptor (GPCR)
Gene: ADRB2
UniProt: P07550 (ADRB2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.21
Drug: darifenacin
Target: D(2) dopamine receptor (GPCR)
Gene: DRD2
UniProt: P14416 (DRD2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.6
Drug: darifenacin
Target: Muscarinic acetylcholine receptor M1 (GPCR)
Gene: CHRM1
UniProt: P11229 (ACM1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.3
Assay: GRAC: human M1 antagonist
Drug: darifenacin
Target: Muscarinic acetylcholine receptor M2 (GPCR)
Gene: CHRM2
UniProt: P08172 (ACM2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.6
Action type: ANTAGONIST
Assay: GRAC: human M2 antagonist
Drug: darifenacin
Target: Muscarinic acetylcholine receptor M3 (GPCR)
Gene: CHRM3
UniProt: P20309 (ACM3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 9.52
Action type: ANTAGONIST
Assay: GRAC: human M3 probe
Drug: darifenacin
Target: Muscarinic acetylcholine receptor M4 (GPCR)
Gene: CHRM4
UniProt: P08173 (ACM4_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.1
Assay: GRAC: human M4 antagonist
Drug: darifenacin
Target: Muscarinic acetylcholine receptor M5 (GPCR)
Gene: CHRM5
UniProt: P08912 (ACM5_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.64
Assay: Binding affinity (Ki) against binding of [3H]NMS using membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M5
Drug: darifenacin
Target: Muscarinic acetylcholine receptor M2 (GPCR)
Gene: Chrm2
UniProt: P10980 (ACM2_RAT)
Organism: Rattus norvegicus
Activity: Ki = 7.2
Assay: Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart
Drug: darifenacin
Target: Muscarinic acetylcholine receptor M3 (GPCR)
Gene: Chrm3
UniProt: P08483 (ACM3_RAT)
Organism: Rattus norvegicus
Activity: Ki = 8.6
Assay: Displacement of [3H]N-methylscopolamine from muscarinic M3 receptor in rat submandibular gland
Drug: dasatinib
Target: Tyrosine-protein kinase JAK3 (Kinase)
Gene: JAK3
UniProt: P52333 (JAK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.19
Assay: Binding constant for JAK3(JH1domain-catalytic) kinase domain
Drug: dasatinib
Target: Platelet-derived growth factor receptor beta (Kinase)
Gene: PDGFRB
UniProt: P09619 (PGFRB_HUMAN)
Organism: Homo sapiens
Activity: Kd = 9.2
Action type: INHIBITOR
Assay: Binding constant for PDGFRB kinase domain
Drug: dasatinib
Target: Tyrosine-protein kinase ABL1 (Kinase)
Gene: ABL1
UniProt: P00519 (ABL1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 9.6
Action type: INHIBITOR
Drug: dasatinib
Target: Mast/stem cell growth factor receptor Kit (Kinase)
Gene: KIT
UniProt: P10721 (KIT_HUMAN)
Organism: Homo sapiens
Activity: Kd = 9.24
Action type: INHIBITOR
Assay: Binding constant for KIT(L576P) kinase domain
Drug: dasatinib
Target: Epidermal growth factor receptor (Kinase)
Gene: EGFR
UniProt: P00533 (EGFR_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.1
Assay: Binding constant for EGFR(G719S) kinase domain
Drug: dasatinib
Target: Serine/threonine-protein kinase mTOR (Kinase)
Gene: MTOR
UniProt: P42345 (MTOR_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.46
Assay: Inhibition of recombinant mTOR by radioactive phosphotransfer assay in presence of 10 uM ATP
Drug: dasatinib
Target: Breakpoint cluster region protein (Kinase)
Gene: BCR
UniProt: P11274 (BCR_HUMAN)
Organism: Homo sapiens
Drug: dasatinib
Target: Proto-oncogene tyrosine-protein kinase Src (Kinase)
Gene: SRC
UniProt: P12931 (SRC_HUMAN)
Organism: Homo sapiens
Activity: Kd = 9.68
Action type: INHIBITOR
Assay: Binding constant for SRC kinase domain
Drug: dasatinib
Target: Tyrosine-protein kinase Lck (Kinase)
Gene: LCK
UniProt: P06239 (LCK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 9.7
Action type: INHIBITOR
Assay: Binding constant for LCK kinase domain
Drug: dasatinib
Target: Tyrosine-protein kinase Yes (Kinase)
Gene: YES1
UniProt: P07947 (YES_HUMAN)
Organism: Homo sapiens
Activity: Kd = 9.52
Action type: INHIBITOR
Assay: Binding constant for YES kinase domain
Drug: dasatinib
Target: Tyrosine-protein kinase Fyn (Kinase)
Gene: FYN
UniProt: P06241 (FYN_HUMAN)
Organism: Homo sapiens
Activity: Kd = 9.1
Action type: INHIBITOR
Assay: Binding constant for FYN kinase domain
Drug: dasatinib
Target: Ephrin type-A receptor 2 (Kinase)
Gene: EPHA2
UniProt: P29317 (EPHA2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 9.07
Action type: INHIBITOR
Assay: Binding constant for EPHA2 kinase domain
Drug: dasatinib
Target: RAF proto-oncogene serine/threonine-protein kinase (Kinase)
Gene: RAF1
UniProt: P04049 (RAF1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.24
Assay: Binding constant for RAF1 kinase domain
Drug: dasatinib
Target: Serine/threonine-protein kinase B-raf (Kinase)
Gene: BRAF
UniProt: P15056 (BRAF_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.3
Assay: Binding constant for BRAF kinase domain