AIM-Harvard/TrialPanorama-filtered huggingface dataset:
Drug: furosemide
Target: Carbonic anhydrase 7 (Enzyme)
Gene: CA7
UniProt: P43166 (CAH7_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.29
Assay: Inhibition of human recombinant full length CA7 by stopped-flow CO2 hydration method
Drug: furosemide
Target: Carbonic anhydrase 6 (Enzyme)
Gene: CA6
UniProt: P23280 (CAH6_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.61
Assay: Inhibition of human recombinant full length CA6 by stopped-flow CO2 hydration method
Drug: furosemide
Target: Carbonic anhydrase 14 (Enzyme)
Gene: CA14
UniProt: Q9ULX7 (CAH14_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.28
Assay: Inhibition of human recombinant full length CA14 by stopped-flow CO2 hydration method
Drug: furosemide
Target: Corticosteroid 11-beta-dehydrogenase isozyme 1 (Enzyme)
Gene: HSD11B1
UniProt: P28845 (DHI1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.42
Assay: Inhibition of human 11beta-HSD1 expressed in HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximity assay in presence of NADPH
Drug: furosemide
Target: Solute carrier family 12 member 2 (Transporter)
Gene: SLC12A2
UniProt: P55011 (S12A2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.13
Action type: INHIBITOR
Drug: furosemide
Target: Carbonic anhydrase 13 (Enzyme)
Gene: Ca13
UniProt: Q9D6N1 (CAH13_MOUSE)
Organism: Mus musculus
Activity: Ki = 6.26
Assay: Inhibition of mouse recombinant full length CA13 by stopped-flow CO2 hydration method
Drug: furosemide
Target: Corticosteroid 11-beta-dehydrogenase isozyme 1 (Enzyme)
Gene: Hsd11b1
UniProt: P50172 (DHI1_MOUSE)
Organism: Mus musculus
Activity: IC50 = 5.42
Assay: Inhibition of mouse 11beta-HSD1 expressed in HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximity assay in presence of NADPH
Drug: furosemide
Target: G-protein coupled receptor 35 (GPCR)
Gene: GPR35
UniProt: Q9HC97 (GPR35_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.49
Assay: Displacement of [3H]PSB-13253 from human recombinant GPR35 exprssed in CHO cells by liquid scintillation counting analysis
Drug: furosemide
Target: Holo-[acyl-carrieir-protein] synthase (Enzyme)
Gene: acpS
UniProt: P96618 (ACPS_BACSU)
Organism: Bacillus subtilis (strain 168)
Activity: IC50 = 4.9
Assay: Inhibitory activity against Bacillus subtilis AcpS by HTRF assay
Drug: furosemide
Target: CDGSH iron-sulfur domain-containing protein 1 (Unclassified)
Gene: CISD1
UniProt: Q9NZ45 (CISD1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.64
Assay: Displacement of [3H]rosiglitazone from recombinant human C-terminal His-tagged MitoNEET cytosolic domain (32 to 108 residues) expressed in Escherichia coli BL21 by Cheng-Prusoff analysis
Drug: fusidic acid
Target: Bile salt export pump (Transporter)
Gene: ABCB11
UniProt: O95342 (ABCBB_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.94
Drug: fusidic acid
Target: Bile salt export pump (Transporter)
Gene: Abcb11
UniProt: O70127 (ABCBB_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 4.76
Drug: aminobutyric acid
Target: Sodium- and chloride-dependent GABA transporter 1 (Transporter)
Gene: SLC6A1
UniProt: P30531 (SC6A1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.3
Assay: Inhibitory activity against human GABA transporter-1 (hGAT1)
Drug: aminobutyric acid
Target: Sodium- and chloride-dependent GABA transporter 1 (Transporter)
Gene: Slc6a1
UniProt: P23978 (SC6A1_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 5.59
Drug: aminobutyric acid
Target: Sodium- and chloride-dependent GABA transporter 1 (Transporter)
Gene: Slc6a1
UniProt: P31648 (SC6A1_MOUSE)
Organism: Mus musculus
Activity: IC50 = 5.14
Drug: aminobutyric acid
Target: Gamma-aminobutyric acid receptor subunit alpha-1 (Ion channel)
Gene: Gabra1
UniProt: P62813 (GBRA1_RAT)
Organism: Rattus norvegicus
Activity: EC50 = 5
Drug: aminobutyric acid
Target: Gamma-aminobutyric acid receptor subunit alpha-2 (Ion channel)
Gene: Gabra2
UniProt: P23576 (GBRA2_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 7.66
Drug: aminobutyric acid
Target: Gamma-aminobutyric acid receptor subunit rho-1 (Ion channel)
Gene: GABRR1
UniProt: P24046 (GBRR1_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 6.57
Assay: Agonist activity at human GABAA rho1 receptor expressed in TSA201 cells after 1 min by FLIPR assay
Drug: aminobutyric acid
Target: Sodium- and chloride-dependent GABA transporter 3 (Transporter)
Gene: SLC6A11
UniProt: P48066 (S6A11_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.15
Assay: Inhibitory activity against human sodium and chloride dependent GABA transporter 3
Drug: aminobutyric acid
Target: Sodium- and chloride-dependent betaine transporter (Transporter)
Gene: SLC6A12
UniProt: P48065 (S6A12_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.44
Assay: Inhibition of human GABA transporter (hBGT-1) activity.
Drug: aminobutyric acid
Target: Sodium- and chloride-dependent GABA transporter 3 (Transporter)
Gene: Slc6a11
UniProt: P31650 (S6A11_MOUSE)
Organism: Mus musculus
Activity: IC50 = 5.09
Drug: aminobutyric acid
Target: Sodium- and chloride-dependent GABA transporter 2 (Transporter)
Gene: Slc6a13
UniProt: P31646 (S6A13_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 5.3
Drug: aminobutyric acid
Target: Sodium- and chloride-dependent GABA transporter 2 (Transporter)
Gene: Slc6a13
UniProt: P31649 (S6A13_MOUSE)
Organism: Mus musculus
Activity: IC50 = 4.56
Drug: aminobutyric acid
Target: Gamma-aminobutyric acid receptor subunit gamma-1 (Ion channel)
Gene: Gabrg1
UniProt: P23574 (GBRG1_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 7.48
Drug: aminobutyric acid
Target: Gamma-aminobutyric acid type B receptor subunit 1 (GPCR)
Gene: Gabbr1
UniProt: Q9Z0U4 (GABR1_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 4.6
Action type: AGONIST
Drug: aminobutyric acid
Target: Sodium- and chloride-dependent GABA transporter 2 (Transporter)
Gene: SLC6A13
UniProt: Q9NSD5 (S6A13_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.58
Assay: Inhibition of human GAT2 expressed in Flp-In CHO cells assessed as reduction in [3H]GABA uptake incubated for 3 mins by liquid scintillation counting method
Drug: gabapentin
Target: Sodium channel protein type 5 subunit alpha (Ion channel)
Gene: SCN5A
UniProt: Q14524 (SCN5A_HUMAN)
Organism: Homo sapiens
Drug: gabapentin
Target: Alpha-2A adrenergic receptor (GPCR)
Gene: ADRA2A
UniProt: P08913 (ADA2A_HUMAN)
Organism: Homo sapiens
Drug: gabapentin
Target: Adenosine receptor A1 (GPCR)
Gene: ADORA1
UniProt: P30542 (AA1R_HUMAN)
Organism: Homo sapiens
Drug: gabapentin
Target: Gamma-aminobutyric acid type B receptor subunit 2 (GPCR)
Gene: GABBR2
UniProt: O75899 (GABR2_HUMAN)
Organism: Homo sapiens
Drug: gabapentin
Target: Glutamate receptor ionotropic, NMDA 3A (Ion channel)
Gene: GRIN3A
UniProt: Q8TCU5 (NMD3A_HUMAN)
Organism: Homo sapiens
Drug: gabapentin
Target: Large neutral amino acids transporter small subunit 1 (Transporter)
Gene: SLC7A5
UniProt: Q01650 (LAT1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.523
Drug: gabapentin
Target: Voltage-dependent calcium channel subunit alpha-2/delta-1 (Ion channel)
Gene: CACNA2D1
UniProt: P54289 (CA2D1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7.26
Action type: MODULATOR
Drug: gabapentin
Target: Potassium voltage-gated channel subfamily KQT member 3 (Ion channel)
Gene: KCNQ3
UniProt: O43525 (KCNQ3_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 8.28
Action type: ACTIVATOR
Drug: gabapentin
Target: Potassium voltage-gated channel subfamily KQT member 5 (Ion channel)
Gene: KCNQ5
UniProt: Q9NR82 (KCNQ5_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 8.72
Action type: ACTIVATOR
Drug: gabapentin
Target: Voltage-dependent calcium channel subunit alpha-2/delta-1 (Ion channel)
Gene: Cacna2d1
UniProt: O08532 (CA2D1_MOUSE)
Organism: Mus musculus
Activity: Ki = 6.92
Assay: Displacement of [3H]L-leucine from alpha-2delta containing calcium channel in murine brain
Drug: gabapentin
Target: Uncharacterized protein; Voltage-dependent calcium channel alpha-2 delta subunit (Ion channel)
Gene: CACNA2D1
UniProt: O77773 (O77773_PIG)
Organism: Sus scrofa
Activity: IC50 = 7.15
Assay: Displacement of [3H]gabapentin from alpha-2delta calcium channel in pig brain membrane
Drug: gabapentin
Target: Voltage-dependent calcium channel subunit alpha-2/delta-2 (Ion channel)
Gene: CACNA2D2
UniProt: Q9NY47 (CA2D2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.928
Action type: MODULATOR
Drug: galantamine
Target: Acetylcholinesterase (Enzyme)
Gene: ACHE
UniProt: P22303 (ACES_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.21
Action type: INHIBITOR
Assay: Inhibition of human recombinant AChE using acetylthiocholine as substrate
Drug: galantamine
Target: Cholinesterase (Enzyme)
Gene: BCHE
UniProt: P06276 (CHLE_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.72
Assay: Inhibition of human recombinant BChE using acetylthiocholine as substrate
Drug: galantamine
Target: Acetylcholinesterase (Enzyme)
Gene: ache
UniProt: P04058 (ACES_TORCA)
Organism: Torpedo californica
Activity: IC50 = 6.44
Assay: Inhibitory activity against acetylcholinesterase (AChE) from Torpedo californica (Reversible type of inhibition)
Drug: galantamine
Target: Acetylcholinesterase (Enzyme)
Gene: Ache
UniProt: P21836 (ACES_MOUSE)
Organism: Mus musculus
Activity: IC50 = 5.6
Assay: Inhibition of ICR mouse brain AChE using acetylthiocholine iodide as substrate incubated 10 mins prior to substrate addition measured after 10 mins by Ellman's method
Drug: galantamine
Target: Butyrylcholinesterase; Protein Bche (Enzyme)
Gene: Bche
UniProt: Q9JKC1 (Q9JKC1_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 5.23
Assay: Inhibition of BChE from rat serum by Ellmans method
Drug: galantamine
Target: Acetylcholinesterase (Enzyme)
Gene: Ache
UniProt: P37136 (ACES_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 6.27
Assay: In vitro inhibitory effect on rat Acetylcholinesterase
Drug: galantamine
Target: Acetylcholinesterase (Enzyme)
Gene: ache
UniProt: O42275 (ACES_ELEEL)
Organism: Electrophorus electricus
Activity: Ki = 6.37
Assay: Competitive inhibition of Electrophorus electricus AChE by Lineweaver-Burke plot analysis
Drug: galantamine
Target: Acetylcholinesterase (Enzyme)
Gene: ACHE
UniProt: P23795 (ACES_BOVIN)
Organism: Bos taurus
Activity: IC50 = 5.06
Assay: Inhibition of bovine AChE by Elman's method
Drug: galantamine
Target: Butyrylcholinesterase (Enzyme)
Gene: BCHE
UniProt: Q9N1N9 (Q9N1N9_HORSE)
Organism: Equus caballus
Activity: Ki = 5.1
Assay: Inhibitory activity against BuChE from horse serum
Drug: galantamine
Target: Cholinesterase (Enzyme)
Gene: BCHE
UniProt: P81908 (CHLE_HORSE)
Organism: Equus caballus
Activity: Ki = 5.03
Assay: Inhibition of equine serum BChE using butyrylthiocholine iodide as substrate after 20 mins measured for 1 min interval for 30 mins by Ellman's method
Drug: gallamine
Target: Muscarinic acetylcholine receptor M1 (GPCR)
Gene: CHRM1
UniProt: P11229 (ACM1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.07
Assay: Competitive inhibition of EGFP-fused human M1 receptor N-terminal truncated at 17 residues expressed in HEK293 cells after 4 hrs by FRET assay in presence of para-LRB-AC42
Drug: gallamine
Target: Acetylcholinesterase (Enzyme)
Gene: ACHE
UniProt: P22303 (ACES_HUMAN)
Organism: Homo sapiens
Activity: Ki = 4.43
Assay: Inhibition of human AChE
Drug: gallamine
Target: Acetylcholinesterase (Enzyme)
Gene: ache
UniProt: P04058 (ACES_TORCA)
Organism: Torpedo californica
Activity: Ki = 4.82
Assay: Inhibition of Torpedo californica AChE
Drug: gallamine
Target: Muscarinic acetylcholine receptor M2 (GPCR)
Gene: Chrm2
UniProt: P10980 (ACM2_RAT)
Organism: Rattus norvegicus
Activity: Ki = 5.6
Action type: ALLOSTERIC MODULATOR
Drug: gallamine
Target: Muscarinic acetylcholine receptor M2 (GPCR)
Gene: CHRM2
UniProt: P06199 (ACM2_PIG)
Organism: Sus scrofa
Activity: EC50 = 6.89
Assay: Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor
Drug: gallamine
Target: Acetylcholine receptor subunit alpha (Ion channel)
Gene: CHRNA1
UniProt: P02708 (ACHA_HUMAN)
Organism: Homo sapiens
Activity: IC50 ~ 6
Action type: BLOCKER
Drug: gallamine
Target: Muscarinic acetylcholine receptor M2 (GPCR)
Gene: CHRM2
UniProt: P08172 (ACM2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.148
Action type: NEGATIVE ALLOSTERIC MODULATOR
Assay: DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)
Drug: gallopamil
Target: Sodium channel alpha subunits; brain (Types I, II, III) (Ion channel)
Gene: SCN1A|SCN2A|SCN3A
UniProt: P35498|Q99250|Q9NY46 (SCN1A_HUMAN|SCN2A_HUMAN|SCN3A_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.44
Assay: Inhibition of binding of Batrachotoxinin [3H]BTX-B to high affinity sites on voltage dependent sodium channels in a vesicular preparation from guinea pig cerebral cortex
Drug: gamolenic acid
Target: 3-oxo-5-alpha-steroid 4-dehydrogenase 2 (Enzyme)
Gene: SRD5A2
UniProt: P31213 (S5A2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.85
Drug: gamolenic acid
Target: Peroxisome proliferator-activated receptor alpha (Nuclear hormone receptor)
Gene: PPARA
UniProt: Q07869 (PPARA_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.57
Assay: Inhibition of PPAR-alpha (unknown origin) by SPA assay
Drug: gamolenic acid
Target: Peroxisome proliferator-activated receptor gamma (Nuclear hormone receptor)
Gene: PPARG
UniProt: P37231 (PPARG_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.66
Assay: Displacement of [3H]BRL49653 from Homo sapiens (human) PPARgamma receptor by scintillation proximity assay
Drug: gamolenic acid
Target: Peroxisome proliferator-activated receptor delta (Nuclear hormone receptor)
Gene: PPARD
UniProt: Q03181 (PPARD_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.12
Assay: Displacement of [3H]GW2433 from Homo sapiens (human) PPARdelta receptor by scintillation proximity assay
Drug: gamolenic acid
Target: Free fatty acid receptor 1 (GPCR)
Gene: FFAR1
UniProt: O14842 (FFAR1_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 5.33
Assay: Agonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assay
Drug: gamolenic acid
Target: Tissue factor (Membrane receptor)
Gene: F3
UniProt: P13726 (TF_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.52
Assay: Inhibition of amidolytic activity of human tissue factor/human factor 7a
Drug: ganciclovir
Target: DNA polymerase catalytic subunit (Enzyme)
UniProt: P04293 (DPOL_HHV11)
Organism: Human herpesvirus 1 (strain 17)
Action type: INHIBITOR
Drug: ganciclovir
Target: Thymidine kinase (Kinase)
Gene: TK
UniProt: Q9QNF7 (KITH_HHV1)
Organism: Human herpesvirus 1
Drug: ganciclovir
Target: Metabotropic glutamate receptor 1 (GPCR)
Gene: GRM1
UniProt: Q13255 (GRM1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.05
Drug: ganciclovir
Target: Metabotropic glutamate receptor 5 (GPCR)
Gene: GRM5
UniProt: P41594 (GRM5_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.41
Drug: ganciclovir
Target: Capsid scaffolding protein (Enzyme)
Gene: UL26
UniProt: P10210 (SCAF_HHV11)
Organism: Human herpesvirus 1 (strain 17)
Activity: EC50 = 6.07
Drug: ganciclovir
Target: Purine nucleoside phosphorylase (Enzyme)
Gene: punA
UniProt: P9WP01 (PUNA_MYCTU)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Activity: Kd = 4.8
Assay: Binding affinity to Mycobacterium tuberculosis purine nucleoside phosphorylase by spectrophotometric analysis
Drug: ganirelix
Target: Gonadotropin-releasing hormone receptor (GPCR)
Gene: GNRHR
UniProt: P30968 (GNRHR_HUMAN)
Organism: Homo sapiens
Action type: ANTAGONIST
Assay: Mechanism of Action; CHEMBL1855; SINGLE PROTEIN
Drug: gatifloxacin
Target: DNA topoisomerase 4 subunit A (Enzyme)
Gene: parC
UniProt: P0C1U9 (PARC_STAAU)
Organism: Staphylococcus aureus
Activity: IC50 = 5.92
Assay: Inhibitory activity against wild type Staphylococcus aureus topoisomerase 4
Drug: gatifloxacin
Target: DNA gyrase subunit A (Enzyme)
Gene: gyrA
UniProt: P9WG47 (GYRA_MYCTU)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Activity: IC50 = 5.03
Assay: Inhibition of DNA supercoiling activity of wild type Mycobacterium tuberculosis DNA gyrase A
Drug: gatifloxacin
Target: DNA topoisomerase 4 (Enzyme)
Gene: parC|parE
UniProt: P72525|Q59961 (PARC_STRPN|PARE_STRPN)
Organism: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Action type: INHIBITOR
Assay: Mechanism of Action; CHEMBL2363033; PROTEIN COMPLEX
Drug: gatifloxacin
Target: DNA gyrase (Enzyme)
Gene: gyrB|gyrA
UniProt: P0A4L9|P72524 (GYRB_STRPN|GYRA_STRPN)
Organism: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Action type: INHIBITOR
Assay: Mechanism of Action; CHEMBL2311225; PROTEIN COMPLEX
Drug: gatifloxacin
Target: DNA gyrase (Enzyme)
Gene: gyrA|gyrB
UniProt: P0AES4|P0AES6 (GYRA_ECOLI|GYRB_ECOLI)
Organism: Escherichia coli (strain K12)
Activity: IC50 = 6.3
Assay: Inhibitory activity against wild type Escherichia coli gyrase
Drug: gefitinib
Target: ATP-binding cassette sub-family G member 2 (Transporter)
Gene: ABCG2
UniProt: Q9UNQ0 (ABCG2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.96
Assay: Inhibition of BCRP expressed in MCF7 MX cells by Hoechst 33342 staining
Drug: gefitinib
Target: Tyrosine-protein kinase ABL1 (Kinase)
Gene: ABL1
UniProt: P00519 (ABL1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.64
Assay: Binding constant for ABL1(Q252H)-phosphorylated kinase domain
Drug: gefitinib
Target: Mast/stem cell growth factor receptor Kit (Kinase)
Gene: KIT
UniProt: P10721 (KIT_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.74
Assay: Binding constant for KIT(A829P) kinase domain
Drug: gefitinib
Target: Epidermal growth factor receptor (Kinase)
Gene: EGFR
UniProt: P00533 (EGFR_HUMAN)
Organism: Homo sapiens
Activity: Ki = 9.4
Action type: INHIBITOR
Assay: Inhibition of EGFR
Drug: gefitinib
Target: Tyrosine-protein kinase Lck (Kinase)
Gene: LCK
UniProt: P06239 (LCK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.2
Assay: Binding constant for LCK kinase domain
Drug: gefitinib
Target: Serine/threonine-protein kinase B-raf (Kinase)
Gene: BRAF
UniProt: P15056 (BRAF_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.7
Assay: Inhibition of BRAF V600E mutant (unknown origin) after 1 to 1.5 hrs by FRET-based Z'-Lyte assay
Drug: gefitinib
Target: Receptor-type tyrosine-protein kinase FLT3 (Kinase)
Gene: FLT3
UniProt: P36888 (FLT3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6
Assay: Binding constant for FLT3(D835Y) kinase domain
Drug: gefitinib
Target: Proto-oncogene tyrosine-protein kinase receptor Ret (Kinase)
Gene: RET
UniProt: P07949 (RET_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.77
Assay: Inhibition of recombinant Ret by radioactive phosphotransfer assay in presence of 10 uM ATP
Drug: gefitinib
Target: Vascular endothelial growth factor receptor 2 (Kinase)
Gene: KDR
UniProt: P35968 (VGFR2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.72
Assay: Inhibition of recombinant VEGFR2 by radioactive phosphotransfer assay in presence of 10 uM ATP
Drug: gefitinib
Target: Receptor tyrosine-protein kinase erbB-2 (Kinase)
Gene: ERBB2
UniProt: P04626 (ERBB2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.96
Assay: Average Binding Constant for ERBB2; NA=Not Active at 10 uM
Drug: gefitinib
Target: Phosphorylase b kinase gamma catalytic chain, liver/testis isoform (Kinase)
Gene: PHKG2
UniProt: P15735 (PHKG2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.57
Assay: Binding constant for PHKG2 kinase domain
Drug: gefitinib
Target: Death-associated protein kinase 3 (Kinase)
Gene: DAPK3
UniProt: O43293 (DAPK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.24
Assay: Binding constant for DAPK3 kinase domain
Drug: gefitinib
Target: Tyrosine-protein kinase HCK (Kinase)
Gene: HCK
UniProt: P08631 (HCK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.36
Assay: Binding constant for HCK kinase domain
Drug: gefitinib
Target: Receptor tyrosine-protein kinase erbB-4 (Kinase)
Gene: ERBB4
UniProt: Q15303 (ERBB4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.39
Assay: Binding constant for ERBB4 kinase domain
Drug: gefitinib
Target: Mitogen-activated protein kinase 10 (Kinase)
Gene: MAPK10
UniProt: P53779 (MK10_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.64
Assay: Average Binding Constant for JNK3; NA=Not Active at 10 uM
Drug: gefitinib
Target: Myosin light chain kinase 2, skeletal/cardiac muscle (Kinase)
Gene: MYLK2
UniProt: Q9H1R3 (MYLK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.72
Assay: Binding constant for MYLK2 kinase domain
Drug: gefitinib
Target: Ephrin type-A receptor 8 (Kinase)
Gene: EPHA8
UniProt: P29322 (EPHA8_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.74
Assay: Binding constant for EPHA8 kinase domain
Drug: gefitinib
Target: Hepatocyte growth factor receptor (Kinase)
Gene: MET
UniProt: P08581 (MET_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.46
Assay: Binding constant for MET(Y1235D) kinase domain
Drug: gefitinib
Target: Tyrosine-protein kinase Lyn (Kinase)
Gene: LYN
UniProt: P07948 (LYN_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6
Assay: Binding constant for LYN kinase domain
Drug: gefitinib
Target: Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform (Kinase)
Gene: PHKG1
UniProt: Q16816 (PHKG1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.43
Assay: Binding constant for full-length PHKG1
Drug: gefitinib
Target: Serine/threonine-protein kinase 17B (Kinase)
Gene: STK17B
UniProt: O94768 (ST17B_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.42
Assay: Binding constant for full-length DRAK2
Drug: gefitinib
Target: Serine/threonine-protein kinase 10 (Kinase)
Gene: STK10
UniProt: O94804 (STK10_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.33
Assay: Binding constant for LOK kinase domain
Drug: gefitinib
Target: Abelson tyrosine-protein kinase 2 (Kinase)
Gene: ABL2
UniProt: P42684 (ABL2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.8
Assay: Binding constant for ABL2 kinase domain
Drug: gefitinib
Target: Ephrin type-A receptor 5 (Kinase)
Gene: EPHA5
UniProt: P54756 (EPHA5_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.82
Assay: Binding constant for EPHA5 kinase domain
Drug: gefitinib
Target: Serine/threonine-protein kinase 17A (Kinase)
Gene: STK17A
UniProt: Q9UEE5 (ST17A_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.7
Assay: Binding constant for DRAK1 kinase domain
Drug: gefitinib
Target: Ephrin type-A receptor 6 (Kinase)
Gene: EPHA6
UniProt: Q9UF33 (EPHA6_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.23
Assay: Binding constant for EPHA6 kinase domain
Drug: gefitinib
Target: TRAF2 and NCK-interacting protein kinase (Kinase)
Gene: TNIK
UniProt: Q9UKE5 (TNIK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.16
Assay: Binding constant for TNIK kinase domain
Drug: gefitinib
Target: Casein kinase I isoform epsilon (Kinase)
Gene: CSNK1E
UniProt: P49674 (KC1E_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.37
Assay: Binding constant for full-length CSNK1E
Drug: gefitinib
Target: Tyrosine-protein kinase Fgr (Kinase)
Gene: FGR
UniProt: P09769 (FGR_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.59
Assay: Binding constant for FGR kinase domain
Drug: gefitinib
Target: Serine/threonine-protein kinase 36 (Kinase)
Gene: STK36
UniProt: Q9NRP7 (STK36_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.24
Assay: Binding constant for STK36 kinase domain
Drug: gefitinib
Target: Ephrin type-A receptor 3 (Kinase)
Gene: EPHA3
UniProt: P29320 (EPHA3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.26
Assay: Binding constant for EPHA3 kinase domain
Drug: gefitinib
Target: Tyrosine-protein kinase FRK (Kinase)
Gene: FRK
UniProt: P42685 (FRK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.7
Assay: Binding constant for FRK kinase domain
Drug: gefitinib
Target: Beta-secretase 1 (Enzyme)
Gene: BACE1
UniProt: P56817 (BACE1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.7
Assay: Inhibition of BACE1 (unknown origin)
Drug: gefitinib
Target: Cyclin-G-associated kinase (Kinase)
Gene: GAK
UniProt: O14976 (GAK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.15
Assay: Average Binding Constant for GAK; NA=Not Active at 10 uM
Drug: gefitinib
Target: Receptor-interacting serine/threonine-protein kinase 2 (Kinase)
Gene: RIPK2
UniProt: O43353 (RIPK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.28
Assay: Binding constant for RIPK2 kinase domain
Drug: gefitinib
Target: Ephrin type-B receptor 1 (Kinase)
Gene: EPHB1
UniProt: P54762 (EPHB1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.89
Assay: Binding constant for EPHB1 kinase domain