AIM-Harvard/TrialPanorama-filtered huggingface dataset:
Drug: vandetanib
Target: Chaperone activity of bc1 complex-like, mitochondrial (Kinase)
Gene: COQ8A
UniProt: Q8NI60 (COQ8A_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.35
Assay: Binding constant for ADCK3 kinase domain
Drug: vandetanib
Target: Serine/threonine-protein kinase MRCK gamma (Kinase)
Gene: CDC42BPG
UniProt: Q6DT37 (MRCKG_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.66
Assay: Binding constant for DMPK2 kinase domain
Drug: vandetanib
Target: Leukocyte tyrosine kinase receptor (Kinase)
Gene: LTK
UniProt: P29376 (LTK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.26
Assay: Binding constant for LTK kinase domain
Drug: vandetanib
Target: Mitogen-activated protein kinase kinase kinase kinase 1 (Kinase)
Gene: MAP4K1
UniProt: Q92918 (M4K1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.26
Assay: Binding constant for HPK1 kinase domain
Drug: vandetanib
Target: Mitogen-activated protein kinase kinase kinase kinase 3 (Kinase)
Gene: MAP4K3
UniProt: Q8IVH8 (M4K3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.82
Assay: Binding constant for MAP4K3 kinase domain
Drug: vandetanib
Target: Tyrosine-protein kinase Blk (Kinase)
Gene: BLK
UniProt: P51451 (BLK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.18
Assay: Binding constant for BLK kinase domain
Drug: vandetanib
Target: Mitogen-activated protein kinase kinase kinase kinase 4 (Kinase)
Gene: MAP4K4
UniProt: O95819 (M4K4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.85
Assay: Binding constant for MAP4K4 kinase domain
Drug: vandetanib
Target: Tyrosine-protein kinase Mer (Kinase)
Gene: MERTK
UniProt: Q12866 (MERTK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.85
Assay: Binding constant for MERTK kinase domain
Drug: vandetanib
Target: Serine/threonine-protein kinase MRCK alpha (Kinase)
Gene: CDC42BPA
UniProt: Q5VT25 (MRCKA_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.59
Assay: Binding constant for MRCKA kinase domain
Drug: vandetanib
Target: Serine/threonine-protein kinase MRCK beta (Kinase)
Gene: CDC42BPB
UniProt: Q9Y5S2 (MRCKB_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.6
Assay: Binding constant for MRCKB kinase domain
Drug: vandetanib
Target: Citron Rho-interacting kinase (Kinase)
Gene: CIT
UniProt: O14578 (CTRO_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.74
Assay: Binding constant for CIT kinase domain
Drug: vandetanib
Target: AarF domain-containing protein kinase 4 (Kinase)
Gene: COQ8B
UniProt: Q96D53 (COQ8B_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.77
Assay: Binding constant for full-length ADCK4
Drug: vandetanib
Target: Serine/threonine-protein kinase SIK1 (Kinase)
Gene: SIK1
UniProt: P57059 (SIK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.72
Assay: Binding constant for SNF1LK kinase domain
Drug: vandetanib
Target: Tyrosine-protein kinase Srms (Kinase)
Gene: SRMS
UniProt: Q9H3Y6 (SRMS_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.72
Assay: Binding constant for SRMS kinase domain
Drug: vandetanib
Target: Dual specificity testis-specific protein kinase 1 (Kinase)
Gene: TESK1
UniProt: Q15569 (TESK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.43
Assay: Binding constant for TESK1 kinase domain
Drug: vandetanib
Target: Ephrin type-A receptor 1 (Kinase)
Gene: EPHA1
UniProt: P21709 (EPHA1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.64
Action type: INHIBITOR
Assay: Binding constant for EPHA1 kinase domain
Drug: vandetanib
Target: Tubulin alpha-1A chain (Structural)
Gene: Tuba1a
UniProt: P68370 (TBA1A_RAT)
Organism: Rattus norvegicus
Activity: Kd = 6.32
Assay: Binding constant for ERBB4 kinase domain
Drug: vandetanib
Target: Mitogen-activated protein kinase 6 (Kinase)
Gene: MAPK6
UniProt: Q16659 (MK06_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.82
Assay: Binding constant for ERK3 kinase domain
Drug: vandetanib
Target: Fibroblast growth factor receptor 4 (Kinase)
Gene: FGFR4
UniProt: P22455 (FGFR4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.64
Assay: Binding constant for FGFR4 kinase domain
Drug: vandetanib
Target: Ribosomal protein S6 kinase alpha-1 (Kinase)
Gene: RPS6KA1
UniProt: Q15418 (KS6A1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.4
Assay: Binding constant for RPS6KA1(Kin.Dom.2 - C-terminal) kinase domain
Drug: vandetanib
Target: Mitogen-activated protein kinase kinase kinase kinase 2 (Kinase)
Gene: MAP4K2
UniProt: Q12851 (M4K2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.8
Assay: Binding constant for MAP4K2 kinase domain
Drug: vandetanib
Target: Misshapen-like kinase 1 (Kinase)
Gene: MINK1
UniProt: Q8N4C8 (MINK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.47
Assay: Binding constant for MINK kinase domain
Drug: vandetanib
Target: Interleukin-1 receptor-associated kinase 4 (Kinase)
Gene: IRAK4
UniProt: Q9NWZ3 (IRAK4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.12
Assay: Binding constant for IRAK4 kinase domain
Drug: vandetanib
Target: Ephrin type-B receptor 6 (Kinase)
Gene: EPHB6
UniProt: O15197 (EPHB6_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.12
Action type: INHIBITOR
Assay: Binding constant for EPHB6 kinase domain
Drug: vandetanib
Target: Hormonally up-regulated neu tumor-associated kinase (Kinase)
Gene: HUNK
UniProt: P57058 (HUNK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.39
Assay: Binding constant for HUNK kinase domain
Drug: vandetanib
Target: Interleukin-1 receptor-associated kinase 1 (Kinase)
Gene: IRAK1
UniProt: P51617 (IRAK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.92
Assay: Binding constant for IRAK1 kinase domain
Drug: vandetanib
Target: Serine/threonine-protein kinase ULK3 (Kinase)
Gene: ULK3
UniProt: Q6PHR2 (ULK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.19
Assay: Binding constant for ULK3 kinase domain
Drug: vandetanib
Target: Mitogen-activated protein kinase kinase kinase 19 (Kinase)
Gene: MAP3K19
UniProt: Q56UN5 (M3K19_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.01
Assay: Binding constant for YSK4 kinase domain
Drug: vandetanib
Target: Receptor-interacting serine/threonine-protein kinase 4 (Kinase)
Gene: RIPK4
UniProt: P57078 (RIPK4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.21
Assay: Binding constant for RIPK4 kinase domain
Drug: vandetanib
Target: Serine/threonine-protein kinase 35 (Kinase)
Gene: STK35
UniProt: Q8TDR2 (STK35_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.25
Assay: Binding constant for STK35 kinase domain
Drug: vandetanib
Target: Receptor tyrosine-protein kinase erbB-3 (Kinase)
Gene: ERBB3
UniProt: P21860 (ERBB3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.8
Action type: INHIBITOR
Assay: Binding constant for ERBB3 kinase domain
Drug: vandetanib
Target: Serine/threonine-protein kinase SIK3 (Kinase)
Gene: SIK3
UniProt: Q9Y2K2 (SIK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.41
Assay: Binding constant for QSK kinase domain
Drug: vandetanib
Target: Bone morphogenetic protein receptor type-1B (Kinase)
Gene: BMPR1B
UniProt: O00238 (BMR1B_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.62
Assay: Binding constant for BMPR1B kinase domain
Drug: vandetanib
Target: Serine/threonine-protein kinase 32A (Kinase)
Gene: STK32A
UniProt: Q8WU08 (ST32A_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.3
Assay: Binding constant for YANK1 kinase domain
Drug: vandetanib
Target: Dual specificity mitogen-activated protein kinase kinase 5 (Kinase)
Gene: MAP2K5
UniProt: Q13163 (MP2K5_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.31
Assay: Binding constant for MEK5 kinase domain
Drug: fidaxomicin
Target: DNA-directed RNA polymerase (Enzyme)
Gene: rpoZ|rpoB|rpoC|rpoA
UniProt: Q182S6|Q18CF1|Q18CF3|Q18CI5 (RPOZ_PEPD6|RPOB_PEPD6|RPOC_PEPD6|RPOA_PEPD6)
Organism: Peptoclostridium difficile (strain 630)
Action type: INHIBITOR
Assay: Mechanism of Action; CHEMBL2363852; PROTEIN COMPLEX
Drug: retigabine
Target: Potassium voltage-gated channel subfamily KQT member 2 (Ion channel)
Gene: KCNQ2
UniProt: O43526 (KCNQ2_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 5.6
Action type: ACTIVATOR
Drug: retigabine
Target: Potassium voltage-gated channel subfamily KQT member 3 (Ion channel)
Gene: KCNQ3
UniProt: O43525 (KCNQ3_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 6.2
Action type: ACTIVATOR
Drug: retigabine
Target: Potassium voltage-gated channel subfamily KQT member 5 (Ion channel)
Gene: KCNQ5
UniProt: Q9NR82 (KCNQ5_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 5
Action type: ACTIVATOR
Drug: retigabine
Target: Potassium voltage-gated channel subfamily KQT member 4 (Ion channel)
Gene: KCNQ4
UniProt: P56696 (KCNQ4_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 5.2
Action type: ACTIVATOR
Drug: retigabine
Target: Potassium voltage-gated channel subfamily KQT member 2 (Ion channel)
Gene: Kcnq2
UniProt: Q9Z351 (KCNQ2_MOUSE)
Organism: Mus musculus
Activity: EC50 = 5.89
Assay: Induction of mouse KCNQ2 expressed in HEK293 cells at -40 mV holding potential by whole-cell patch clamp assay
Drug: rivaroxaban
Target: Coagulation factor X (Enzyme)
Gene: F10
UniProt: P00742 (FA10_HUMAN)
Organism: Homo sapiens
Activity: Ki = 9.4
Action type: INHIBITOR
Assay: Inhibition of Factor 10a
Drug: rivaroxaban
Target: Suppressor of tumorigenicity 14 protein (Enzyme)
Gene: ST14
UniProt: Q9Y5Y6 (ST14_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.47
Drug: rivaroxaban
Target: Coagulation factor X (Enzyme)
Gene: F10
UniProt: O19045 (FA10_RABIT)
Organism: Oryctolagus cuniculus
Activity: IC50 = 6.29
Drug: indacaterol
Target: Beta-1 adrenergic receptor (GPCR)
Gene: ADRB1
UniProt: P08588 (ADRB1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.04
Assay: Displacement of [3H]CGP12177 from human beta-1 adrenoceptor
Drug: indacaterol
Target: Beta-2 adrenergic receptor (GPCR)
Gene: ADRB2
UniProt: P07550 (ADRB2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.8
Action type: AGONIST
Assay: Binding affinity to human beta2-adrenoceptor by radioligand binding assay
Drug: indacaterol
Target: D(2) dopamine receptor (GPCR)
Gene: DRD2
UniProt: P14416 (DRD2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.6
Assay: Binding affinity to dopamine 2 receptor
Drug: indacaterol
Target: D(3) dopamine receptor (GPCR)
Gene: DRD3
UniProt: P35462 (DRD3_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.98
Drug: indacaterol
Target: Beta-2 adrenergic receptor (GPCR)
Gene: Adrb2
UniProt: Q8K4Z4 (ADRB2_CAVPO)
Organism: Cavia porcellus
Activity: IC50 = 8.1
Drug: ticagrelor
Target: P2Y purinoceptor 12 (GPCR)
Gene: P2RY12
UniProt: Q9H244 (P2Y12_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.85
Action type: NEGATIVE ALLOSTERIC MODULATOR
Assay: Displacement of [33P]2-MeS-ADP from human recombinant P2Y12 receptor expressed in CHO cell membranes by scintillation counting method
Drug: ticagrelor
Target: Equilibrative nucleoside transporter 1 (Transporter)
Gene: SLC29A1
UniProt: Q99808 (S29A1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.3
Action type: INHIBITOR
Drug: ticagrelor
Target: P2Y purinoceptor 12 (GPCR)
Gene: P2ry12
UniProt: Q9EPX4 (P2Y12_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 5.38
Drug: vemurafenib
Target: RAF proto-oncogene serine/threonine-protein kinase (Kinase)
Gene: RAF1
UniProt: P04049 (RAF1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7.32
Assay: Inhibition of C-Raf in presence of 100 uM ATP
Drug: vemurafenib
Target: Serine/threonine-protein kinase B-raf (Kinase)
Gene: BRAF
UniProt: P15056 (BRAF_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7.68
Action type: INHIBITOR
Assay: Inhibition of wild type BRAF (unknown origin)
Drug: vemurafenib
Target: Vascular endothelial growth factor receptor 2 (Kinase)
Gene: KDR
UniProt: P35968 (VGFR2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.44
Drug: vemurafenib
Target: Mitogen-activated protein kinase kinase kinase MLT (Kinase)
Gene: ZAK
UniProt: Q9NYL2 (MLTK_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7.64
Assay: Inhibition of human ZAK (5 to 309 residues) expressed in baculovirus infected Sf9 insect cells using ZAKtide as substrate after 1 hr by mass spectrometry
Drug: vemurafenib
Target: Serine/threonine-protein kinase A-Raf (Kinase)
Gene: ARAF
UniProt: P10398 (ARAF_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.02
Drug: vemurafenib
Target: GTPase KRas (Enzyme)
Gene: KRAS
UniProt: P01116 (RASK_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.78
Assay: Inhibition of KRAS G13D mutant in human HCT116 cells assessed as inhibition of ERK phosphorylation by ELISA
Drug: vemurafenib
Target: Ferrochelatase, mitochondrial (Enzyme)
Gene: FECH
UniProt: P22830 (HEMH_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 5.3
Assay: Stabilization of FECH in human K562 cells after 1 hr by thermal shift assay
Drug: vemurafenib
Target: Serine/threonine-protein kinase B-raf (Kinase)
Gene: Braf
UniProt: P28028 (BRAF_MOUSE)
Organism: Mus musculus
Activity: IC50 = 7.52
Assay: Inhibition of mouse full length GST-tagged BRAF V600E mutant using recombinant human full length N-terminal His-tagged MEK1 as substrate preincubated for 1 hr followed by substrate addition measured after 25 mins
Drug: icatibant
Target: B2 bradykinin receptor (GPCR)
Gene: BDKRB2
UniProt: P30411 (BKRB2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 10.22
Action type: ANTAGONIST
Assay: Binding affinity towards human cloned Bradykinin receptor B2 expressed in CHO cells by [3H]bradykinin displacement.
Drug: icatibant
Target: B2 bradykinin receptor (GPCR)
Gene: Bdkrb2
UniProt: P25023 (BKRB2_RAT)
Organism: Rattus norvegicus
Activity: Ki = 10.11
Assay: Binding affinity against rat bradykinin B2 receptors expressed in CHO cells using [3H]bradykinin as radioligand
Drug: icatibant
Target: B2 bradykinin receptor (GPCR)
Gene: BDKRB2
UniProt: O70526 (BKRB2_CAVPO)
Organism: Cavia porcellus
Activity: Ki = 9.96
Assay: In vitro binding affinity against bradykinin receptor B2 from guinea pig ileum.
Drug: icatibant
Target: B1 bradykinin receptor (GPCR)
Gene: BDKRB1
UniProt: P46663 (BKRB1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7
Action type: ANTAGONIST
Drug: icatibant
Target: B2 bradykinin receptor (GPCR)
Gene: Bdkrb2
UniProt: P32299 (BKRB2_MOUSE)
Organism: Mus musculus
Activity: Ki = 9.6
Action type: ANTAGONIST
Drug: icatibant
Target: B1 bradykinin receptor (GPCR)
Gene: Bdkrb1
UniProt: P97583 (BKRB1_RAT)
Organism: Rattus norvegicus
Activity: Ki = 6.4
Action type: ANTAGONIST
Drug: crizotinib
Target: Tyrosine-protein kinase JAK3 (Kinase)
Gene: JAK3
UniProt: P52333 (JAK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.7
Assay: Binding constant for JAK3(JH1domain-catalytic) kinase domain
Drug: crizotinib
Target: Macrophage-stimulating protein receptor (Kinase)
Gene: MST1R
UniProt: Q04912 (RON_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.6
Assay: Binding constant for MST1R kinase domain
Drug: crizotinib
Target: Tyrosine-protein kinase ABL1 (Kinase)
Gene: ABL1
UniProt: P00519 (ABL1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8
Assay: Binding constant for ABL1(T315I)-phosphorylated kinase domain
Drug: crizotinib
Target: Mast/stem cell growth factor receptor Kit (Kinase)
Gene: KIT
UniProt: P10721 (KIT_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.1
Assay: Binding constant for KIT(V559D,T670I) kinase domain
Drug: crizotinib
Target: Epidermal growth factor receptor (Kinase)
Gene: EGFR
UniProt: P00533 (EGFR_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.57
Assay: Binding constant for EGFR(G719C) kinase domain
Drug: crizotinib
Target: Proto-oncogene tyrosine-protein kinase Src (Kinase)
Gene: SRC
UniProt: P12931 (SRC_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.25
Assay: Binding constant for SRC kinase domain
Drug: crizotinib
Target: Tyrosine-protein kinase Lck (Kinase)
Gene: LCK
UniProt: P06239 (LCK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.52
Assay: Binding constant for LCK kinase domain
Drug: crizotinib
Target: Tyrosine-protein kinase Yes (Kinase)
Gene: YES1
UniProt: P07947 (YES_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.11
Assay: Binding constant for YES kinase domain
Drug: crizotinib
Target: Tyrosine-protein kinase Fyn (Kinase)
Gene: FYN
UniProt: P06241 (FYN_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.89
Assay: Binding constant for FYN kinase domain
Drug: crizotinib
Target: Ephrin type-A receptor 2 (Kinase)
Gene: EPHA2
UniProt: P29317 (EPHA2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7
Assay: Binding constant for EPHA2 kinase domain
Drug: crizotinib
Target: Receptor-type tyrosine-protein kinase FLT3 (Kinase)
Gene: FLT3
UniProt: P36888 (FLT3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.68
Assay: Binding constant for FLT3(D835Y) kinase domain
Drug: crizotinib
Target: Proto-oncogene tyrosine-protein kinase receptor Ret (Kinase)
Gene: RET
UniProt: P07949 (RET_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.89
Assay: Binding constant for RET(M918T) kinase domain
Drug: crizotinib
Target: Vascular endothelial growth factor receptor 1 (Kinase)
Gene: FLT1
UniProt: P17948 (VGFR1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.64
Assay: Binding constant for FLT1 kinase domain
Drug: crizotinib
Target: Macrophage colony-stimulating factor 1 receptor (Kinase)
Gene: CSF1R
UniProt: P07333 (CSF1R_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.68
Assay: Binding constant for CSF1R kinase domain
Drug: crizotinib
Target: Insulin-like growth factor 1 receptor (Kinase)
Gene: IGF1R
UniProt: P08069 (IGF1R_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.11
Assay: Binding constant for IGF1R kinase domain
Drug: crizotinib
Target: Insulin receptor (Kinase)
Gene: INSR
UniProt: P06213 (INSR_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.47
Action type: AGONIST
Assay: Binding constant for INSR kinase domain
Drug: crizotinib
Target: Fibroblast growth factor receptor 3 (Kinase)
Gene: FGFR3
UniProt: P22607 (FGFR3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.57
Assay: Binding constant for FGFR3 kinase domain
Drug: crizotinib
Target: Rho-associated protein kinase 1 (Kinase)
Gene: ROCK1
UniProt: Q13464 (ROCK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.43
Assay: Binding constant for ROCK1 kinase domain
Drug: crizotinib
Target: Focal adhesion kinase 1 (Kinase)
Gene: PTK2
UniProt: Q05397 (FAK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.51
Assay: Binding constant for FAK kinase domain
Drug: crizotinib
Target: Tyrosine-protein kinase JAK1 (Kinase)
Gene: JAK1
UniProt: P23458 (JAK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.48
Assay: Binding constant for JAK1(JH1domain-catalytic) kinase domain
Drug: crizotinib
Target: High affinity nerve growth factor receptor (Kinase)
Gene: NTRK1
UniProt: P04629 (NTRK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.02
Assay: Binding constant for TRKA kinase domain
Drug: crizotinib
Target: Tyrosine-protein kinase JAK2 (Kinase)
Gene: JAK2
UniProt: O60674 (JAK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.54
Assay: Binding constant for JAK2(JH1domain-catalytic) kinase domain
Drug: crizotinib
Target: Rho-associated protein kinase 2 (Kinase)
Gene: ROCK2
UniProt: O75116 (ROCK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.48
Assay: Binding constant for ROCK2 kinase domain
Drug: crizotinib
Target: Tyrosine-protein kinase SYK (Kinase)
Gene: SYK
UniProt: P43405 (KSYK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.6
Assay: Binding constant for SYK kinase domain
Drug: crizotinib
Target: Angiopoietin-1 receptor (Kinase)
Gene: TEK
UniProt: Q02763 (TIE2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.57
Assay: Binding constant for TIE2 kinase domain
Drug: crizotinib
Target: Ephrin type-A receptor 8 (Kinase)
Gene: EPHA8
UniProt: P29322 (EPHA8_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.55
Assay: Binding constant for EPHA8 kinase domain
Drug: crizotinib
Target: AP2-associated protein kinase 1 (Kinase)
Gene: AAK1
UniProt: Q2M2I8 (AAK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.64
Assay: Binding constant for AAK1 kinase domain
Drug: crizotinib
Target: Hepatocyte growth factor receptor (Kinase)
Gene: MET
UniProt: P08581 (MET_HUMAN)
Organism: Homo sapiens
Activity: Kd = 9.26
Action type: INHIBITOR
Assay: Binding constant for MET(M1250T) kinase domain
Drug: crizotinib
Target: Tyrosine-protein kinase Lyn (Kinase)
Gene: LYN
UniProt: P07948 (LYN_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.03
Assay: Binding constant for LYN kinase domain
Drug: crizotinib
Target: Cytoplasmic tyrosine-protein kinase BMX (Kinase)
Gene: BMX
UniProt: P51813 (BMX_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.44
Assay: Binding constant for BMX kinase domain
Drug: crizotinib
Target: LIM domain kinase 1 (Kinase)
Gene: LIMK1
UniProt: P53667 (LIMK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.08
Assay: Binding constant for LIMK1 kinase domain
Drug: crizotinib
Target: 5'-AMP-activated protein kinase catalytic subunit alpha-1 (Kinase)
Gene: PRKAA1
UniProt: Q13131 (AAPK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.62
Assay: Binding constant for AMPK-alpha1 kinase domain
Drug: crizotinib
Target: Serine/threonine-protein kinase 10 (Kinase)
Gene: STK10
UniProt: O94804 (STK10_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.36
Assay: Binding constant for LOK kinase domain
Drug: crizotinib
Target: Tyrosine-protein kinase Fer (Kinase)
Gene: FER
UniProt: P16591 (FER_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.57
Assay: Binding constant for FER kinase domain
Drug: crizotinib
Target: Serine/threonine-protein kinase PLK4 (Kinase)
Gene: PLK4
UniProt: O00444 (PLK4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.22
Assay: Binding constant for PLK4 kinase domain
Drug: crizotinib
Target: Aurora kinase C (Kinase)
Gene: AURKC
UniProt: Q9UQB9 (AURKC_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.37
Assay: Binding constant for AURKC kinase domain
Drug: crizotinib
Target: Abelson tyrosine-protein kinase 2 (Kinase)
Gene: ABL2
UniProt: P42684 (ABL2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.34
Assay: Binding constant for ABL2 kinase domain
Drug: crizotinib
Target: Ephrin type-A receptor 5 (Kinase)
Gene: EPHA5
UniProt: P54756 (EPHA5_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6
Assay: Binding constant for EPHA5 kinase domain
Drug: crizotinib
Target: Ephrin type-A receptor 4 (Kinase)
Gene: EPHA4
UniProt: P54764 (EPHA4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.44
Assay: Binding constant for EPHA4 kinase domain
Drug: crizotinib
Target: Ephrin type-A receptor 6 (Kinase)
Gene: EPHA6
UniProt: Q9UF33 (EPHA6_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.19
Assay: Binding constant for EPHA6 kinase domain
Drug: crizotinib
Target: Tyrosine-protein kinase Fgr (Kinase)
Gene: FGR
UniProt: P09769 (FGR_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.17
Assay: Binding constant for FGR kinase domain
Drug: crizotinib
Target: Aurora kinase A (Kinase)
Gene: AURKA
UniProt: O14965 (AURKA_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.59
Assay: Binding constant for AURKA kinase domain
Drug: crizotinib
Target: ALK tyrosine kinase receptor (Kinase)
Gene: ALK
UniProt: Q9UM73 (ALK_HUMAN)
Organism: Homo sapiens
Activity: Ki = 9.13
Action type: INHIBITOR
Assay: Inhibition of wild type human recombinant ALK kinase domain (amino acids 1093 to 1141) expressed in baculovirus system using 5'FAM-KKSRGDYMTMQIG-CONH2 as substrate incubated for 15 mins prior to ATP addition measured after 1 hr by microfluidic mobility shift assay
Drug: crizotinib
Target: Ephrin type-A receptor 3 (Kinase)
Gene: EPHA3
UniProt: P29320 (EPHA3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.15
Assay: Binding constant for EPHA3 kinase domain
Drug: crizotinib
Target: BMP-2-inducible protein kinase (Kinase)
Gene: BMP2K
UniProt: Q9NSY1 (BMP2K_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.13
Assay: Binding constant for BIKE kinase domain
Drug: crizotinib
Target: Tyrosine-protein kinase FRK (Kinase)
Gene: FRK
UniProt: P42685 (FRK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.54
Assay: Binding constant for FRK kinase domain
Drug: crizotinib
Target: Mitogen-activated protein kinase kinase kinase kinase 5 (Kinase)
Gene: MAP4K5
UniProt: Q9Y4K4 (M4K5_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.1
Assay: Binding constant for MAP4K5 kinase domain
Drug: crizotinib
Target: Receptor-interacting serine/threonine-protein kinase 2 (Kinase)
Gene: RIPK2
UniProt: O43353 (RIPK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.05
Assay: Binding constant for RIPK2 kinase domain
Drug: crizotinib
Target: Ephrin type-B receptor 1 (Kinase)
Gene: EPHB1
UniProt: P54762 (EPHB1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.92
Assay: Binding constant for EPHB1 kinase domain
Drug: crizotinib
Target: Serine/threonine-protein kinase 4 (Kinase)
Gene: STK4
UniProt: Q13043 (STK4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.24
Assay: Binding constant for MST1 kinase domain