AIM-Harvard/TrialPanorama-filtered huggingface dataset:
Drug: tirbanibulin
Target: Proto-oncogene tyrosine-protein kinase Src (Kinase)
Gene: SRC
UniProt: P12931 (SRC_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.34
Action type: INHIBITOR
Assay: Low affinity is expected because the peptide substrate binding site is not well formed when Src is isolated.
Drug: tirbanibulin
Target: Tyrosine-protein kinase Lyn (Kinase)
Gene: LYN
UniProt: P07948 (LYN_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7
Assay: Inhibition of LYN (unknown origin)
Drug: relugolix
Target: Gonadotropin-releasing hormone receptor (GPCR)
Gene: Gnrhr
UniProt: P30969 (GNRHR_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 9.48
Action type: ANTAGONIST
Drug: relugolix
Target: Gonadotropin-releasing hormone receptor (GPCR)
Gene: GNRHR
UniProt: P30968 (GNRHR_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 9.92
Action type: ANTAGONIST
Drug: ansuvimab
Target: Envelope glycoprotein (Glycoprotein)
Gene: GP
UniProt: P87666 (VGP_EBOZ5)
Organism: Zaire ebolavirus (strain Kikwit-95)
Activity: Kd = 9.7
Action type: ANTIBODY BINDING
Assay: Ansuvimab-zykl binds EBOV GP without the mucin domain at pH 7.4
Drug: margetuximab
Target: Receptor tyrosine-protein kinase erbB-2 (Kinase)
Gene: ERBB2
UniProt: P04626 (ERBB2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.55
Action type: ANTAGONIST
Assay: Mechanism of Action
Drug: margetuximab
Target: Low affinity immunoglobulin gamma Fc region receptor III-A (Membrane receptor)
Gene: FCGR3A
UniProt: P08637 (FCG3A_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.05
Action type: ANTAGONIST
Assay: Affinity for 158V allele of human CD16A
Drug: atoltivimab
Target: Low affinity immunoglobulin gamma Fc region receptor III-A (Membrane receptor)
Gene: FCGR3A
UniProt: P08637 (FCG3A_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 8.64
Action type: ANTIBODY BINDING
Assay: With EBOV Makona-GP expressing cell line and Jurkat/NFAT-Luc/FcγRIIIa reporter effector cells
Drug: atoltivimab
Target: Envelope glycoprotein (Glycoprotein)
Gene: GP
UniProt: P87666 (VGP_EBOZ5)
Organism: Zaire ebolavirus (strain Kikwit-95)
Activity: Kd = 8.11
Action type: ANTIBODY BINDING
Assay: Binding to the GP determined simultaneosly for atoltivimab, odesivimab, and maftivimab by surface plasmon resonance
Drug: maftivimab
Target: Envelope glycoprotein (Glycoprotein)
Gene: GP
UniProt: P87666 (VGP_EBOZ5)
Organism: Zaire ebolavirus (strain Kikwit-95)
Activity: Kd = 8.48
Action type: ANTIBODY BINDING
Assay: Binding to the GP determined simultaneosly for atoltivimab, odesivimab, and maftivimab by surface plasmon resonance
Drug: odesivimab
Target: Low affinity immunoglobulin gamma Fc region receptor III-A (Membrane receptor)
Gene: FCGR3A
UniProt: P08637 (FCG3A_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 8.8
Action type: ANTIBODY BINDING
Assay: With EBOV Makona-GP expressing cell line and Jurkat/NFAT-Luc/FcγRIIIa reporter effector cells
Drug: odesivimab
Target: Envelope glycoprotein (Glycoprotein)
Gene: GP
UniProt: P87666 (VGP_EBOZ5)
Organism: Zaire ebolavirus (strain Kikwit-95)
Activity: Kd = 8.08
Action type: ANTIBODY BINDING
Assay: Binding to the GP determined simultaneosly for atoltivimab, odesivimab, and maftivimab by surface plasmon resonance
Drug: vericiguat
Target: Guanylate cyclase soluble subunit beta-1 (Enzyme)
Gene: Gucy1b1
UniProt: P20595 (GCYB1_RAT)
Organism: Rattus norvegicus
Activity: EC50 = 6
Action type: ACTIVATOR
Assay: Recombinant CHO cell line overexpressing rat sGC
Drug: vericiguat
Target: Guanylate cyclase soluble subunit beta-1 (Enzyme)
Gene: GUCY1B3
UniProt: Q02153 (GCYB1_HUMAN)
Organism: Homo sapiens
Action type: ACTIVATOR
Assay: Mechanism of Action
Drug: cabotegravir
Target: Integrase (Enzyme)
UniProt: Q76353 (Q76353_9HIV1)
Organism: Human immunodeficiency virus 1
Activity: IC50 = 8.52
Assay: Inhibition of HIV-1 integrase strand transfer activity using [3H]-DNA as substrate preincubated for 60 mins prior to substrate addition measured after 25 to 45 mins
Drug: cabotegravir
Target: Integrase (Unclassified)
UniProt: Q76353 (Q76353_9HIV1)
Organism: Human immunodeficiency virus 1
Activity: IC50 = 8.52
Assay: Inhibition of HIV-1 integrase strand transfer activity using [3H]-DNA as substrate preincubated for 60 mins prior to substrate addition measured after 25 to 45 mins
Drug: cabotegravir
Target: Integrase (Enzyme)
Gene: pol
UniProt: Q7ZJM1 (Q7ZJM1_9HIV1)
Organism: Human immunodeficiency virus 1
Activity: IC50 = 8.52
Action type: INHIBITOR
Assay: Strand transfer assay using purified recombinant HIV-1 integrase
Drug: umbralisib
Target: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Kinase)
Gene: PIK3CA
UniProt: P42336 (PK3CA_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5
Action type: INHIBITOR
Drug: umbralisib
Target: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Kinase)
Gene: PIK3CB
UniProt: P42338 (PK3CB_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5
Action type: INHIBITOR
Drug: umbralisib
Target: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Kinase)
Gene: PIK3CG
UniProt: P48736 (PK3CG_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.85
Action type: INHIBITOR
Drug: umbralisib
Target: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Kinase)
Gene: PIK3CD
UniProt: O00329 (PK3CD_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.21
Action type: INHIBITOR
Assay: Mechanism of Action
Drug: umbralisib
Target: Casein kinase I isoform epsilon (Kinase)
Gene: CSNK1E
UniProt: P49674 (KC1E_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.74
Action type: INHIBITOR
Assay: Mechanism of Action
Drug: trilaciclib
Target: Receptor-type tyrosine-protein kinase FLT3 (Kinase)
Gene: FLT3
UniProt: P36888 (FLT3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 9.15
Action type: INHIBITOR
Drug: trilaciclib
Target: Cyclin-dependent kinase 1 (Kinase)
Gene: CDK1
UniProt: P06493 (CDK1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.53
Action type: INHIBITOR
Drug: trilaciclib
Target: Cyclin-dependent kinase 2 (Kinase)
Gene: CDK2
UniProt: P24941 (CDK2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.72
Action type: INHIBITOR
Drug: trilaciclib
Target: Cyclin-dependent-like kinase 5 (Kinase)
Gene: CDK5
UniProt: Q00535 (CDK5_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.83
Action type: INHIBITOR
Drug: trilaciclib
Target: Cyclin-dependent kinase 9 (Kinase)
Gene: CDK9
UniProt: P50750 (CDK9_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7.3
Action type: INHIBITOR
Drug: trilaciclib
Target: Cyclin-dependent kinase 7 (Kinase)
Gene: CDK7
UniProt: P50613 (CDK7_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.33
Action type: INHIBITOR
Drug: trilaciclib
Target: NUAK family SNF1-like kinase 2 (Kinase)
Gene: NUAK2
UniProt: Q9H093 (NUAK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 9.15
Action type: INHIBITOR
Drug: trilaciclib
Target: Serine/threonine-protein kinase Nek10 (Kinase)
Gene: NEK10
UniProt: Q6ZWH5 (NEK10_HUMAN)
Organism: Homo sapiens
Activity: Kd = 9.57
Action type: INHIBITOR
Drug: trilaciclib
Target: Cyclin-dependent kinase 6 (Kinase)
Gene: CDK6
UniProt: Q00534 (CDK6_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 8.4
Action type: INHIBITOR
Assay: Mechanism of Action
Drug: trilaciclib
Target: Cyclin-dependent kinase 4 (Kinase)
Gene: CDK4
UniProt: P11802 (CDK4_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 9
Action type: INHIBITOR
Assay: Mechanism of Action
Drug: casimersen
Target: exon 53 of dystrophin pre-mRNA (RNA)
Gene: DMD
UniProt: P11532 (DMD_HUMAN)
Organism: Homo sapiens
Action type: ANTISENSE INHIBITOR
Assay: Mechanism of Action
Drug: fosdenopterin
Target: Molybdenum cofactor biosynthesis protein 1 (Enzyme)
Gene: MOCS1
UniProt: Q9NZB8 (MOCS1_HUMAN)
Organism: Homo sapiens
Assay: Mechanism of Action
Drug: ponesimod
Target: Sphingosine 1-phosphate receptor 5 (GPCR)
Gene: S1PR5
UniProt: Q9H228 (S1PR5_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 7.23
Action type: AGONIST
Drug: ponesimod
Target: Sphingosine 1-phosphate receptor 4 (GPCR)
Gene: S1PR4
UniProt: O95977 (S1PR4_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 5.96
Action type: AGONIST
Drug: ponesimod
Target: Sphingosine 1-phosphate receptor 3 (GPCR)
Gene: S1PR3
UniProt: Q99500 (S1PR3_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 6.94
Action type: AGONIST
Drug: ponesimod
Target: Sphingosine 1-phosphate receptor 1 (GPCR)
Gene: S1PR1
UniProt: P21453 (S1PR1_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 8.13
Action type: AGONIST
Assay: Mechanism of Action
Drug: dasiglucagon
Target: Glucagon receptor (GPCR)
Gene: GCGR
UniProt: P47871 (GLR_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 11
Action type: AGONIST
Drug: evinacumab
Target: Angiopoietin-related protein 3 (Secreted)
Gene: ANGPTL3
UniProt: Q9Y5C1 (ANGL3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 9.04
Action type: INHIBITOR
Assay: Mechanism of Action
Drug: estetrol
Target: Estrogen receptor (Nuclear hormone receptor)
Gene: ESR1
UniProt: P03372 (ESR1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.31
Action type: MODULATOR
Assay: Mechanism of Action
Drug: estetrol
Target: Estrogen receptor beta (Nuclear hormone receptor)
Gene: ESR2
UniProt: Q92731 (ESR2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.72
Action type: MODULATOR
Assay: Mechanism of Action
Drug: dostarlimab
Target: Programmed cell death protein 1 (Membrane receptor)
Gene: PDCD1
UniProt: Q15116 (PDCD1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.82
Action type: ANTIBODY BINDING
Assay: Mechanism of Action
Drug: loncastuximab tesirine
Target: B-lymphocyte antigen CD19 (Surface antigen)
Gene: CD19
UniProt: P15391 (CD19_HUMAN)
Organism: Homo sapiens
Action type: ANTIBODY BINDING
Assay: MoA - Monoclonal IgG1 kappa antibody component binds to human CD19
Drug: bamlanivimab
Target: Spike glycoprotein (Glycoprotein)
Gene: S
UniProt: P0DTC2 (SPIKE_SARS2)
Organism: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2)
Activity: Kd = 10.15
Assay: Mechanism of Action
Drug: etesevimab
Target: Spike glycoprotein (Glycoprotein)
Gene: S
UniProt: P0DTC2 (SPIKE_SARS2)
Organism: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2)
Activity: Kd = 8.19
Assay: Mechanism of Action
Drug: casirivimab
Target: Spike glycoprotein (Glycoprotein)
Gene: S
UniProt: P0DTC2 (SPIKE_SARS2)
Organism: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2)
Activity: Kd = 10.34
Assay: Mechanism of Action
Drug: imdevimab
Target: Spike glycoprotein (Glycoprotein)
Gene: S
UniProt: P0DTC2 (SPIKE_SARS2)
Organism: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2)
Activity: Kd = 10.33
Assay: Mechanism of Action
Drug: pegcetacoplan
Target: Complement C3 (Unclassified)
Gene: C3
UniProt: P01024 (CO3_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.6
Action type: INHIBITOR
Assay: MoA - inhibition of complement activation evaluated in ELISA assay
Drug: piflufolastat F-18
Target: Glutamate carboxypeptidase 2 (Enzyme)
Gene: FOLH1
UniProt: Q04609 (FOLH1_HUMAN)
Organism: Homo sapiens
Action type: BINDING AGENT
Assay: Mechanism of Action
Drug: infigratinib
Target: Macrophage-stimulating protein receptor (Kinase)
Gene: MST1R
UniProt: Q04912 (RON_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.54
Assay: Inhibition of RON-mediated proliferation of mouse BAF3 cells transformed with TEL-Kinase construct
Drug: infigratinib
Target: Tyrosine-protein kinase ABL1 (Kinase)
Gene: ABL1
UniProt: P00519 (ABL1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.64
Assay: Inhibition of recombinant ABL kinase
Drug: infigratinib
Target: Mast/stem cell growth factor receptor Kit (Kinase)
Gene: KIT
UniProt: P10721 (KIT_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.12
Assay: Inhibition of recombinant KIT kinase
Drug: infigratinib
Target: Proto-oncogene tyrosine-protein kinase Src (Kinase)
Gene: SRC
UniProt: P12931 (SRC_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.53
Assay: Inhibition of SRC-mediated proliferation of mouse BAF3 cells transformed with TEL-Kinase construct
Drug: infigratinib
Target: Tyrosine-protein kinase Lck (Kinase)
Gene: LCK
UniProt: P06239 (LCK_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.6
Assay: Inhibition of recombinant LCK kinase
Drug: infigratinib
Target: Tyrosine-protein kinase Yes (Kinase)
Gene: YES1
UniProt: P07947 (YES_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.96
Assay: Inhibition of recombinant YES kinase
Drug: infigratinib
Target: Tyrosine-protein kinase Fyn (Kinase)
Gene: FYN
UniProt: P06241 (FYN_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.72
Assay: Inhibition of recombinant FYN kinase
Drug: infigratinib
Target: Serine/threonine-protein kinase B-raf (Kinase)
Gene: BRAF
UniProt: P15056 (BRAF_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.38
Assay: Inhibition of B-RAF V600E mutant-mediated proliferation of mouse BAF3 cells transformed with TEL-Kinase construct
Drug: infigratinib
Target: Receptor-type tyrosine-protein kinase FLT3 (Kinase)
Gene: FLT3
UniProt: P36888 (FLT3_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.49
Assay: Inhibition of FLT3-mediated proliferation of mouse BAF3 cells transformed with TEL-Kinase construct
Drug: infigratinib
Target: Proto-oncogene tyrosine-protein kinase receptor Ret (Kinase)
Gene: RET
UniProt: P07949 (RET_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.47
Assay: Inhibition of RET juxtamembrane domain-mediated proliferation of mouse BAF3 cells transformed with TEL-Kinase construct
Drug: infigratinib
Target: Vascular endothelial growth factor receptor 1 (Kinase)
Gene: FLT1
UniProt: P17948 (VGFR1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.82
Assay: Inhibition of VEGFR1 juxtamembrane domain-mediated proliferation of mouse BAF3 cells transformed with TEL-Kinase construct
Drug: infigratinib
Target: Vascular endothelial growth factor receptor 2 (Kinase)
Gene: KDR
UniProt: P35968 (VGFR2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.74
Action type: INHIBITOR
Drug: infigratinib
Target: Vascular endothelial growth factor receptor 3 (Kinase)
Gene: FLT4
UniProt: P35916 (VGFR3_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.68
Assay: Inhibition of VEGFR3 juxtamembrane domain-mediated proliferation of mouse BAF3 cells transformed with TEL-Kinase construct
Drug: infigratinib
Target: Platelet-derived growth factor receptor alpha (Kinase)
Gene: PDGFRA
UniProt: P16234 (PGFRA_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.57
Assay: Inhibition of PDGFRalpha-mediated proliferation of mouse BAF3 cells transformed with TEL-Kinase construct
Drug: infigratinib
Target: Insulin receptor (Kinase)
Gene: INSR
UniProt: P06213 (INSR_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.47
Assay: Inhibition of INSR-mediated proliferation of mouse BAF3 cells transformed with TEL-Kinase construct
Drug: infigratinib
Target: Tyrosine-protein kinase JAK2 (Kinase)
Gene: JAK2
UniProt: O60674 (JAK2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.54
Assay: Inhibition of JAK2-mediated proliferation of mouse BAF3 cells transformed with TEL-Kinase construct
Drug: infigratinib
Target: Tyrosine-protein kinase SYK (Kinase)
Gene: SYK
UniProt: P43405 (KSYK_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.27
Assay: Inhibition of SYK-mediated proliferation of mouse BAF3 cells transformed with TEL-Kinase construct
Drug: infigratinib
Target: Angiopoietin-1 receptor (Kinase)
Gene: TEK
UniProt: Q02763 (TIE2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.69
Assay: Inhibition of TIE2-mediated proliferation of mouse BAF3 cells transformed with TEL-Kinase construct
Drug: infigratinib
Target: Hepatocyte growth factor receptor (Kinase)
Gene: MET
UniProt: P08581 (MET_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.52
Assay: Inhibition of MET-mediated proliferation of mouse BAF3 cells transformed with TEL-Kinase construct
Drug: infigratinib
Target: Tyrosine-protein kinase Lyn (Kinase)
Gene: LYN
UniProt: P07948 (LYN_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.52
Assay: Inhibition of recombinant LYN kinase
Drug: infigratinib
Target: Cytoplasmic tyrosine-protein kinase BMX (Kinase)
Gene: BMX
UniProt: P51813 (BMX_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.47
Assay: Inhibition of BMX-mediated proliferation of mouse BAF3 cells transformed with TEL-Kinase construct
Drug: infigratinib
Target: ALK tyrosine kinase receptor (Kinase)
Gene: ALK
UniProt: Q9UM73 (ALK_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.51
Assay: Inhibition of ALK juxtamembrane domain-mediated proliferation of mouse BAF3 cells transformed with TEL-Kinase construct
Drug: infigratinib
Target: Ephrin type-B receptor 1 (Kinase)
Gene: EPHB1
UniProt: P54762 (EPHB1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.52
Assay: Inhibition of EPHB1-mediated proliferation of mouse BAF3 cells transformed with TEL-Kinase construct
Drug: infigratinib
Target: BDNF/NT-3 growth factors receptor (Kinase)
Gene: NTRK2
UniProt: Q16620 (NTRK2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.5
Assay: Inhibition of TRKB juxtamembrane domain-mediated proliferation of mouse BAF3 cells transformed with TEL-Kinase construct
Drug: infigratinib
Target: Non-receptor tyrosine-protein kinase TYK2 (Kinase)
Gene: TYK2
UniProt: P29597 (TYK2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.48
Assay: Inhibition of TYK2-mediated proliferation of mouse BAF3 cells transformed with TEL-Kinase construct
Drug: infigratinib
Target: Proto-oncogene tyrosine-protein kinase ROS (Kinase)
Gene: ROS1
UniProt: P08922 (ROS1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.49
Assay: Inhibition of ROS-mediated proliferation of mouse BAF3 cells transformed with TEL-Kinase construct
Drug: infigratinib
Target: Smoothened homolog (GPCR)
Gene: SMO
UniProt: Q99835 (SMO_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.33
Assay: Displacement of [3H]-cyclopamine from SMO V404M mutant in gefitinib resistant human HCC827 cells by scintillation counting
Drug: infigratinib
Target: Fibroblast growth factor receptor 3 (Kinase)
Gene: FGFR3
UniProt: P22607 (FGFR3_HUMAN)
Organism: Homo sapiens
Activity:  = 8.7
Action type: INHIBITOR
Drug: infigratinib
Target: Fibroblast growth factor receptor 2 (Kinase)
Gene: FGFR2
UniProt: P21802 (FGFR2_HUMAN)
Organism: Homo sapiens
Activity:  = 9
Action type: INHIBITOR
Drug: infigratinib
Target: Fibroblast growth factor receptor 4 (Kinase)
Gene: FGFR4
UniProt: P22455 (FGFR4_HUMAN)
Organism: Homo sapiens
Activity:  = 7.21
Action type: INHIBITOR
Drug: infigratinib
Target: Fibroblast growth factor receptor 1 (Kinase)
Gene: FGFR1
UniProt: P11362 (FGFR1_HUMAN)
Organism: Homo sapiens
Activity:  = 8.99
Action type: INHIBITOR
Assay: Mechanism of Action
Drug: samidorphan
Target: Mu-type opioid receptor (GPCR)
Gene: OPRM1
UniProt: P35372 (OPRM_HUMAN)
Organism: Homo sapiens
Activity: Ki = 10.28
Action type: ANTAGONIST
Assay: Possible target for the mechanism of action of the drug
Drug: samidorphan
Target: Kappa-type opioid receptor (GPCR)
Gene: OPRK1
UniProt: P41145 (OPRK_HUMAN)
Organism: Homo sapiens
Activity: Ki = 9.64
Action type: PARTIAL AGONIST
Drug: samidorphan
Target: Delta-type opioid receptor (GPCR)
Gene: OPRD1
UniProt: P41143 (OPRD_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.59
Action type: PARTIAL AGONIST
Drug: sotorasib
Target: GTPase KRas (Enzyme)
Gene: KRAS
UniProt: P01116 (RASK_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7.03
Action type: INHIBITOR
Assay: KRAS G12C mutation
Drug: ibrexafungerp
Target: Beta-1,3-glucan synthase catalytic subunit 1 (Enzyme)
Gene: GSC1
UniProt: O13428 (O13428_CANAX)
Organism: Candida albicans
Activity: IC50 = 8.35
Action type: INHIBITOR
Assay: MoA - inhibits the biosynthesis of beta-(1,3)-glucan
Drug: ibrexafungerp
Target: 1,3-Beta-D-glucan-UDP glucosyltransferase (Enzyme)
Gene: FKS1
UniProt: Q6FTN8 (Q6FTN8_CANGA)
Organism: Candida glabrata
Activity: IC50 = 7.83
Action type: INHIBITOR
Assay: MoA - inhibits the biosynthesis of beta-(1,3)-glucan
Drug: ibrexafungerp
Target: 1,3-Beta-D-glucan-UDP glucosyltransferase (Enzyme)
Gene: FKS
UniProt: P87204 (P87204_ASPFM)
Organism: Neosartorya fumigata
Activity: IC50 = 8.97
Action type: INHIBITOR
Assay: MoA - inhibits the biosynthesis of beta-(1,3)-glucan