AIM-Harvard/TrialPanorama-filtered huggingface dataset:
Drug: pemetrexed
Target: Trifunctional purine biosynthetic protein adenosine-3 (Enzyme)
Gene: Gart
UniProt: Q64737 (PUR2_MOUSE)
Organism: Mus musculus
Activity: Ki = 5.03
Action type: INHIBITOR
Drug: pemetrexed
Target: Trifunctional purine biosynthetic protein adenosine-3 (Enzyme)
Gene: GART
UniProt: P22102 (PUR2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.42
Action type: INHIBITOR
Assay: Inhibition of GARFT
Drug: pemoline
Target: Sodium-dependent dopamine transporter (Transporter)
Gene: SLC6A3
UniProt: Q01959 (SC6A3_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.383
Assay: DRUGMATRIX: Dopamine Transporter radioligand binding (ligand: [125I] RTI-55)
Drug: penbutolol
Target: Beta-1 adrenergic receptor (GPCR)
Gene: ADRB1
UniProt: P08588 (ADRB1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.8
Action type: ANTAGONIST
Drug: penbutolol
Target: Beta-2 adrenergic receptor (GPCR)
Gene: ADRB2
UniProt: P07550 (ADRB2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 9
Action type: ANTAGONIST
Drug: penbutolol
Target: 5-hydroxytryptamine receptor 1A (GPCR)
Gene: HTR1A
UniProt: P08908 (5HT1A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.92
Drug: penbutolol
Target: Alpha-1-acid glycoprotein 1 (Secreted)
Gene: ORM1
UniProt: P02763 (A1AG1_HUMAN)
Organism: Homo sapiens
Drug: penbutolol
Target: 5-hydroxytryptamine receptor 1A (GPCR)
Gene: Htr1a
UniProt: P19327 (5HT1A_RAT)
Organism: Rattus norvegicus
Activity: Ki = 8.62
Drug: penciclovir
Target: DNA polymerase catalytic subunit (Enzyme)
UniProt: P04293 (DPOL_HHV11)
Organism: Human herpesvirus 1 (strain 17)
Action type: INHIBITOR
Drug: penciclovir
Target: Thymidine kinase (Kinase)
Gene: TK
UniProt: Q9QNF7 (KITH_HHV1)
Organism: Human herpesvirus 1
Activity: IC50 = 4.96
Assay: Inhibition of recombinant HSV-1 TK assessed as [CH3-H3]dThd phosphorylation
Drug: penciclovir
Target: Thymidine kinase (Kinase)
Gene: UL23
UniProt: A3RLP8 (A3RLP8_CHV1)
Organism: Cercopithecine herpesvirus 1
Activity: IC50 = 4.07
Assay: Inhibition of Herpes B virus recombinant thymidine kinase-mediated [3H]TdR phosphorylation
Drug: penfluridol
Target: Mu-type opioid receptor (GPCR)
Gene: OPRM1
UniProt: P35372 (OPRM_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.06
Assay: Displacement of [3H]DAMGO from human MOR expressed in HEK cells by radioligand binding assay
Drug: penfluridol
Target: D(1A) dopamine receptor (GPCR)
Gene: DRD1
UniProt: P21728 (DRD1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.83
Assay: Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assay
Drug: penfluridol
Target: D(2) dopamine receptor (GPCR)
Gene: DRD2
UniProt: P14416 (DRD2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.8
Assay: Displacement of [3H]N-methylspiperone from human dopamine D2 receptor expressed in stable fibroblast cells by radioligand binding assay
Drug: penfluridol
Target: 5-hydroxytryptamine receptor 1A (GPCR)
Gene: HTR1A
UniProt: P08908 (5HT1A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.45
Assay: Displacement of [3H]-Way100635 from human 5HT1A receptor expressed in stable CHO cell membranes by radioligand binding assay
Drug: penfluridol
Target: 5-hydroxytryptamine receptor 2A (GPCR)
Gene: HTR2A
UniProt: P28223 (5HT2A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.44
Assay: Displacement of [3H]Ketanserin from 5-HT2A receptor (unknown origin) by radioligand binding assay
Drug: penfluridol
Target: 5-hydroxytryptamine receptor 2B (GPCR)
Gene: HTR2B
UniProt: P41595 (5HT2B_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.74
Assay: Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assay
Drug: penfluridol
Target: 5-hydroxytryptamine receptor 2C (GPCR)
Gene: HTR2C
UniProt: P28335 (5HT2C_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.682
Drug: penfluridol
Target: 5-hydroxytryptamine receptor 6 (GPCR)
Gene: HTR6
UniProt: P50406 (5HT6R_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6
Assay: Displacement of [3H]LSD from human 5-HT6 receptor expressed in HEK cells by radioligand binding assay
Drug: penfluridol
Target: Alpha-2B adrenergic receptor (GPCR)
Gene: ADRA2B
UniProt: P18089 (ADA2B_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.4
Assay: Displacement of [3H]Rauwolscine from human alpha 2B adrenergic receptor expressed in HEK293T cells by radioligand binding assay
Drug: penfluridol
Target: D(3) dopamine receptor (GPCR)
Gene: DRD3
UniProt: P35462 (DRD3_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.87
Assay: Displacement of [3H]N-methylspiperone from human dopamine D3 receptor expressed in HEK293T cells by radioligand binding assay
Drug: penfluridol
Target: D(1B) dopamine receptor (GPCR)
Gene: DRD5
UniProt: P21918 (DRD5_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.9
Assay: Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cells by radioligand binding assay
Drug: penfluridol
Target: Histamine H1 receptor (GPCR)
Gene: HRH1
UniProt: P35367 (HRH1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6
Assay: Displacement of [3H]Pyrilamine from human H1 receptor expressed in HEK cells by radioligand binding assay
Drug: penfluridol
Target: Histamine H2 receptor (GPCR)
Gene: HRH2
UniProt: P25021 (HRH2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6
Assay: Displacement of [3H]Cimetidine from human H2 receptor expressed in HEK cells by radioligand binding assay
Drug: penfluridol
Target: Beta-3 adrenergic receptor (GPCR)
Gene: ADRB3
UniProt: P13945 (ADRB3_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.29
Assay: Displacement of [3H]CGP12177 from human beta 3 adrenergic receptor expressed in HEK293FlpIN cells by radioligand binding assay
Drug: penfluridol
Target: 5-hydroxytryptamine receptor 1D (GPCR)
Gene: HTR1D
UniProt: P28221 (5HT1D_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.45
Assay: Displacement of [3H]5-CT from human 5-HT1D receptor expressed in HEK293T cells by radioligand binding assay
Drug: penfluridol
Target: Alpha-2C adrenergic receptor (GPCR)
Gene: ADRA2C
UniProt: P18825 (ADA2C_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.35
Assay: Displacement of [3H]Rauwolscine from human alpha 2C adrenergic receptor expressed in MDCK cells by radioligand binding assay
Drug: penfluridol
Target: D(4) dopamine receptor (GPCR)
Gene: DRD4
UniProt: P21917 (DRD4_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6
Assay: Displacement of [3H]N-methylspiperone from human dopamine D4 receptor by radioligand binding assay
Drug: penfluridol
Target: Alpha-1D adrenergic receptor (GPCR)
Gene: ADRA1D
UniProt: P25100 (ADA1D_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.22
Assay: Displacement of [3H]Prazosin from human alpha 1D adrenergic receptor expressed in HEK cells by radioligand binding assay
Drug: penfluridol
Target: Kappa-type opioid receptor (GPCR)
Gene: OPRK1
UniProt: P41145 (OPRK_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6
Assay: Displacement of [3H]U69593 from KOR (unknown origin) expressed in HEK cells by radioligand binding assay
Drug: penfluridol
Target: Delta-type opioid receptor (GPCR)
Gene: OPRD1
UniProt: P41143 (OPRD_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.77
Assay: Displacement of [3H]DADLE from human DOR expressed in HEK cells by radioligand binding assay
Drug: penfluridol
Target: 5-hydroxytryptamine receptor 5A (GPCR)
Gene: HTR5A
UniProt: P47898 (5HT5A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6
Assay: Displacement of [3H]LSD from human 5-HT5A receptor expressed in Flp-In CHO cells by radioligand binding assay
Drug: penfluridol
Target: Dopamine receptor (GPCR)
Gene: Drd1|Drd3|Drd5|Drd4|Drd2
UniProt: P18901|P19020|P25115|P30729|P61169 (DRD1_RAT|DRD3_RAT|DRD5_RAT|DRD4_RAT|DRD2_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 7.21
Assay: Inhibition of [3H]spiroperidol (0.5 nM) binding to dopamine receptor from rat striatal membrane.
Drug: penicillamine
Target: Succinyl-diaminopimelate desuccinylase (Enzyme)
Gene: dapE
UniProt: P44514 (DAPE_HAEIN)
Organism: Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Activity: IC50 = 4.3
Assay: Inhibition of Haemophilus influenzae recombinant DapE
Drug: benzylpenicillin
Target: Penicillin-binding protein 1A (Enzyme)
Gene: pbpA
UniProt: Q8XJ01 (PBPA_CLOPE)
Organism: Clostridium perfringens (strain 13 / Type A)
Drug: benzylpenicillin
Target: Beta-lactamase TEM (Enzyme)
Gene: bla; blaT-3; blaT-4;
UniProt: P62593 (BLAT_ECOLX)
Organism: Escherichia coli
Activity: Ki = 4.7
Assay: Inhibition constant (Ki) for TEM-1 beta-lactamase
Drug: benzylpenicillin
Target: Beta-lactamase (Enzyme)
Gene: ampC
UniProt: P05364 (AMPC_ENTCL)
Organism: Enterobacter cloacae
Activity: IC50 = 5.44
Assay: Inhibition of Enterobacter cloacae beta-lactamase incubated for 10 mins followed by nitrocefin substrate challenge and measured for 5 mins in presence of Triton X-100 by spectrophotometric analysis
Drug: benzylpenicillin
Target: Bacterial penicillin-binding protein (Enzyme)
Gene: mrcA|mrcB|dacC|mrdA|ftsI|dacA|dacB
UniProt: P02918|P02919|P08506|P0AD65|P0AD68|P0AEB2|P24228 (PBPA_ECOLI|PBPB_ECOLI|DACC_ECOLI|PBP2_ECOLI|FTSI_ECOLI|DACA_ECOLI|DACB_ECOLI)
Organism: Escherichia coli (strain K12)
Action type: INHIBITOR
Assay: Mechanism of Action; CHEMBL2354204; PROTEIN FAMILY
Drug: phenoxymethylpenicillin
Target: Penicillin-binding protein 1A (Enzyme)
Gene: pbpA
UniProt: Q8XJ01 (PBPA_CLOPE)
Organism: Clostridium perfringens (strain 13 / Type A)
Drug: phenoxymethylpenicillin
Target: Bacterial penicillin-binding protein (Enzyme)
Gene: mrcA|mrcB|dacC|mrdA|ftsI|dacA|dacB
UniProt: P02918|P02919|P08506|P0AD65|P0AD68|P0AEB2|P24228 (PBPA_ECOLI|PBPB_ECOLI|DACC_ECOLI|PBP2_ECOLI|FTSI_ECOLI|DACA_ECOLI|DACB_ECOLI)
Organism: Escherichia coli (strain K12)
Action type: INHIBITOR
Assay: Mechanism of Action; CHEMBL2354204; PROTEIN FAMILY
Drug: pentagastrin
Target: Gastrin/cholecystokinin type B receptor (GPCR)
Gene: CCKBR
UniProt: P32239 (GASR_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.84
Assay: Inhibition of binding of [125I]-PD 142308 to CCK-B receptor was determined
Drug: pentagastrin
Target: Cholecystokinin receptor type A (GPCR)
Gene: Cckar
UniProt: P30551 (CCKAR_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 6.22
Assay: Evaluated for inhibition of cholecystokinin type A receptor by displacing [125I]bolton hunter CCK-8 radioligand in the rat pancreas
Drug: pentagastrin
Target: Gastrin/cholecystokinin type B receptor (GPCR)
Gene: Cckbr
UniProt: P30553 (GASR_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 8.17
Assay: Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
Drug: pentagastrin
Target: Gastrin/cholecystokinin type B receptor (GPCR)
Gene: Cckbr
UniProt: P56481 (GASR_MOUSE)
Organism: Mus musculus
Activity: IC50 = 9.1
Assay: Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
Drug: pentamidine
Target: Alpha-2A adrenergic receptor (GPCR)
Gene: ADRA2A
UniProt: P08913 (ADA2A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.287
Assay: DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)
Drug: pentamidine
Target: Potassium voltage-gated channel subfamily H member 2 (Ion channel)
Gene: KCNH2
UniProt: Q12809 (KCNH2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 4.89
Assay: DRUGMATRIX: Potassium Channel HERG radioligand binding (ligand: [3H] Astemizole)
Drug: pentamidine
Target: Sodium-dependent noradrenaline transporter (Transporter)
Gene: SLC6A2
UniProt: P23975 (SC6A2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.658
Assay: DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55)
Drug: pentamidine
Target: 5-hydroxytryptamine receptor 2A (GPCR)
Gene: HTR2A
UniProt: P28223 (5HT2A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.33
Assay: DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin)
Drug: pentamidine
Target: 5-hydroxytryptamine receptor 2C (GPCR)
Gene: HTR2C
UniProt: P28335 (5HT2C_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.765
Assay: DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine)
Drug: pentamidine
Target: D(3) dopamine receptor (GPCR)
Gene: DRD3
UniProt: P35462 (DRD3_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.867
Assay: DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone)
Drug: pentamidine
Target: Muscarinic acetylcholine receptor M2 (GPCR)
Gene: CHRM2
UniProt: P08172 (ACM2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.295
Assay: DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)
Drug: pentamidine
Target: Muscarinic acetylcholine receptor M4 (GPCR)
Gene: CHRM4
UniProt: P08173 (ACM4_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.658
Assay: DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine)
Drug: pentamidine
Target: Muscarinic acetylcholine receptor M5 (GPCR)
Gene: CHRM5
UniProt: P08912 (ACM5_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.683
Assay: DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
Drug: pentamidine
Target: Sodium-dependent dopamine transporter (Transporter)
Gene: SLC6A3
UniProt: Q01959 (SC6A3_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.6
Assay: DRUGMATRIX: Dopamine Transporter radioligand binding (ligand: [125I] RTI-55)
Drug: pentamidine
Target: Alpha-1D adrenergic receptor (GPCR)
Gene: ADRA1D
UniProt: P25100 (ADA1D_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.309
Assay: DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug: pentamidine
Target: Amine oxidase [flavin-containing] A (Enzyme)
Gene: MAOA
UniProt: P21397 (AOFA_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.101
Assay: DRUGMATRIX: Monoamine Oxidase MAO-A enzyme inhibition (substrate: Kynuramine)
Drug: pentamidine
Target: Plasminogen (Enzyme)
Gene: PLG
UniProt: P00747 (PLMN_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.44
Assay: Inhibition of human plasmin assessed as reduction in protein-mediated thrombin-induced fibrin rich clot lysis measured over 5 to 100 mins
Drug: pentamidine
Target: Trypsin-1 (Enzyme)
Gene: PRSS1
UniProt: P07477 (TRY1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.64
Assay: Inhibition of trypsin by amidase assay.
Drug: pentamidine
Target: Coagulation factor X (Enzyme)
Gene: F10
UniProt: P00742 (FA10_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.98
Assay: Inhibition of human factor 10a preincubated for 10 mins followed by spectrozyme FXa addition
Drug: pentamidine
Target: Suppressor of tumorigenicity 14 protein (Enzyme)
Gene: ST14
UniProt: Q9Y5Y6 (ST14_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.94
Assay: compound was tested for inhibitory activity against Matriptase
Drug: pentamidine
Target: Protein S100-B (Cytosolic other)
Gene: S100B
UniProt: P04271 (S100B_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6
Assay: Binding to holo-S100B protein
Drug: pentamidine
Target: Protein arginine N-methyltransferase 1 (Enzyme)
Gene: PRMT1
UniProt: Q99873 (ANM1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.09
Assay: Inhibition of PRMT1 (unknown origin) assessed as reduction in methyl transfer from [3H]-SAM to biotinylated histone H4 peptide H4-20-Biotin at 10 uM pre-incubated for 3 mins before [3H]-SAM addition and measured after 15 mins by scintillation proximity assay
Drug: pentamidine
Target: Solute carrier family 22 member 1 (Transporter)
Gene: SLC22A1
UniProt: O15245 (S22A1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.66
Assay: Inhibition of human OCT1-mediated ASP+ uptake expressed in HEK293 cells after 3 mins by fluorescence assay
Drug: pentamidine
Target: Amiloride-sensitive amine oxidase [copper-containing] (Enzyme)
Gene: AOC1
UniProt: P19801 (AOC1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.54
Assay: Mixed type inhibition of recombinant human DAO expressed in drosophila S2 cells
Drug: pentamidine
Target: Alpha-1B adrenergic receptor (GPCR)
Gene: Adra1b
UniProt: P15823 (ADA1B_RAT)
Organism: Rattus norvegicus
Activity: Ki = 6.272
Assay: DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
Drug: pentamidine
Target: Alpha-1A adrenergic receptor (GPCR)
Gene: Adra1a
UniProt: P43140 (ADA1A_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 5.92
Drug: pentamidine
Target: Solute carrier family 22 member 2 (Transporter)
Gene: SLC22A2
UniProt: O15244 (S22A2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.92
Assay: Inhibition of human OCT2-mediated ASP+ uptake expressed in HEK293 cells after 3 mins by fluorescence assay
Drug: pentamidine
Target: Multidrug and toxin extrusion protein 1 (Transporter)
Gene: SLC47A1
UniProt: Q96FL8 (S47A1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.39
Assay: Inhibition of human MATE1-mediated [14]-metformin uptake expressed in polarized MDCK2 cells after 5 mins by liquid scintillation counting analysis
Drug: pentamidine
Target: Multidrug and toxin extrusion protein 2 (Transporter)
Gene: SLC47A2
UniProt: Q86VL8 (S47A2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.57
Assay: Inhibition of human MATE2K-mediated ASP+ uptake expressed in HEK293 cells up to 500 uM after 1.5 mins by fluorescence assay
Drug: pentamidine
Target: Solute carrier family 22 member 3 (Transporter)
Gene: SLC22A3
UniProt: O75751 (S22A3_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.02
Assay: Inhibition of human OCT3-mediated ASP+ uptake expressed in HEK293 cells after 3 mins by fluorescence assay
Drug: pentamidine
Target: Glutamate NMDA receptor (Ion channel)
Gene: Grin1|Grin2a|Grin2b|Grin2c|Grin2d|Grin3b|Grin3a
UniProt: P35439|Q00959|Q00960|Q00961|Q62645|Q8VHN2|Q9R1M7 (NMDZ1_RAT|NMDE1_RAT|NMDE2_RAT|NMDE3_RAT|NMDE4_RAT|NMD3B_RAT|NMD3A_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 5.88
Assay: Inhibition of [3H]MK-801 binding to the NMDA receptor of rat hippocampal membranes, measured in buffer containing 20 mM TRIS acetate, pH 7
Drug: pentamidine
Target: Glutamate NMDA receptor; GRIN1/GRIN2A (Ion channel)
Gene: GRIN1|GRIN2A
UniProt: Q05586|Q12879 (NMDZ1_HUMAN|NMDE1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.14
Assay: Antagonist activity at NR1/NR2A receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of glutamate/glycine-induced current at pH 7.6 at -40mV holding potential by two-electrode voltage-clamp electrophysiology
Drug: pentamidine
Target: Spermidine/spermine N(1)-acetyltransferase 1 (Enzyme)
Gene: SAT1
UniProt: P21673 (SAT1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.7
Assay: Inhibition of human SSAT using spermidine as substrate
Drug: pentamidine
Target: Protein-tyrosine phosphatase 4A3 (Enzyme)
Gene: PTP4A3
UniProt: O75365 (TP4A3_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.27
Assay: Inhibition of human recombinant PRL-3
Drug: pentamidine
Target: Acrosin (Enzyme)
Gene: ACR
UniProt: P08001 (ACRO_PIG)
Organism: Sus scrofa
Activity: Ki = 5.64
Assay: Reversible competitive inhibition of boar spermatozoa acrosin using BzArgOEt as substrate by Dixon plot analysis
Drug: pentamidine
Target: Protein S100-B (Unclassified)
Gene: S100b
UniProt: P04631 (S100B_RAT)
Organism: Rattus norvegicus
Activity: Kd = 4.36
Assay: Binding affinity to recombinant rat calcium loaded S100-B by fluorescence spectrophotometric analysis
Drug: pentamidine
Target: Protein tyrosine phosphatase type IVA 2 (Enzyme)
Gene: PTP4A2
UniProt: Q12974 (TP4A2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.52
Assay: Inhibition of PTP4A2 (unknown origin)
Drug: pentamidine
Target: Protein tyrosine phosphatase type IVA 1 (Enzyme)
Gene: PTP4A1
UniProt: Q93096 (TP4A1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.52
Assay: Inhibition of PTP4A1 (unknown origin)
Drug: pentobarbital
Target: Gamma-aminobutyric acid receptor subunit beta-3 (Ion channel)
Gene: GABRB3
UniProt: P28472 (GBRB3_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.06
Action type: POSITIVE ALLOSTERIC MODULATOR
Assay: Displacement of [3H]R-(-)-14 from human FLAG-tagged beta3 GABA A receptor expressed in HEK293S cells
Drug: pentobarbital
Target: Potassium voltage-gated channel subfamily H member 2 (Ion channel)
Gene: KCNH2
UniProt: Q12809 (KCNH2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 2.553
Drug: pentobarbital
Target: GABA-A receptor alpha-1/beta-2/gamma-2 (Ion channel)
Gene: GABRA1|GABRG2|GABRB2
UniProt: P14867|P18507|P47870 (GBRA1_HUMAN|GBRG2_HUMAN|GBRB2_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 4.301
Action type: POSITIVE ALLOSTERIC MODULATOR
Drug: pentobarbital
Target: GABA-A receptor; anion channel (Ion channel)
Gene: Gabrp|Gabrb1|Gabrd|Gabrg2|Gabra5|Gabra3|Gabrg1|Gabra2|Gabra4|Gabrg3|Gabra6|Gabra1|Gabrb3|Gabrb2|Gabrq|Gabre
UniProt: O09028|P15431|P18506|P18508|P19969|P20236|P23574|P23576|P28471|P28473|P30191|P62813|P63079|P63138|Q91ZM7|Q9ES14 (GBRP_RAT|GBRB1_RAT|GBRD_RAT|GBRG2_RAT|GBRA5_RAT|GBRA3_RAT|GBRG1_RAT|GBRA2_RAT|GBRA4_RAT|GBRG3_RAT|GBRA6_RAT|GBRA1_RAT|GBRB3_RAT|GBRB2_RAT|Q91ZM7_RAT|GBRE_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 5.77
Assay: Ability to allosterically modulate the binding of [35S]TBPS to gamma-aminobutyric-acid A receptor in rat brain cortical P2 membranes.
Drug: pentobarbital
Target: GABA A receptor alpha-2/beta-2/gamma-2 (Ion channel)
Gene: GABRG2|GABRA2|GABRB2
UniProt: P18507|P47869|P47870 (GBRG2_HUMAN|GBRA2_HUMAN|GBRB2_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 4.3
Assay: Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expressed in Xenopus oocytes
Drug: pentolonium
Target: Neuronal acetylcholine receptor subunit alpha-10 (Ion channel)
Gene: CHRNA10
UniProt: Q9GZZ6 (ACH10_HUMAN)
Organism: Homo sapiens
Drug: pentolonium
Target: Neuronal acetylcholine receptor; alpha3/beta4 (Ion channel)
Gene: CHRNB4|CHRNA3
UniProt: P30926|P32297 (ACHB4_HUMAN|ACHA3_HUMAN)
Organism: Homo sapiens
Action type: ANTAGONIST
Assay: Mechanism of Action; CHEMBL1907594; PROTEIN COMPLEX
Drug: pentostatin
Target: Adenosine deaminase (Enzyme)
Gene: ADA
UniProt: P00813 (ADA_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 10.8
Action type: INHIBITOR
Drug: pentostatin
Target: Adenosine deaminase (Enzyme)
Gene: ADA
UniProt: P56658 (ADA_BOVIN)
Organism: Bos taurus
Activity: Ki = 11
Assay: Binding affinity against Adenosine deaminase from calf intestinal mucosa was determined
Drug: pentoxifylline
Target: Adenosine receptor A2b (GPCR)
Gene: ADORA2B
UniProt: P29275 (AA2BR_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.29
Action type: ANTAGONIST
Assay: Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand
Drug: pentoxifylline
Target: cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Enzyme)
Gene: PDE4B
UniProt: Q07343 (PDE4B_HUMAN)
Organism: Homo sapiens
Action type: INHIBITOR
Drug: pentoxifylline
Target: Acetylcholinesterase (Enzyme)
Gene: ACHE
UniProt: P22303 (ACES_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.18
Assay: Inhibition of human AChE using acetylthiocholine iodide as substrate treated 5 mins before substrate addition measured up to 4 mins by Ellman's method
Drug: pentoxifylline
Target: cGMP-specific 3',5'-cyclic phosphodiesterase (Enzyme)
Gene: PDE5A
UniProt: O76074 (PDE5A_HUMAN)
Organism: Homo sapiens
Action type: INHIBITOR
Drug: pergolide
Target: Alpha-2A adrenergic receptor (GPCR)
Gene: ADRA2A
UniProt: P08913 (ADA2A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.3
Drug: pergolide
Target: Potassium voltage-gated channel subfamily H member 2 (Ion channel)
Gene: KCNH2
UniProt: Q12809 (KCNH2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.92
Assay: Inhibition of human ERG
Drug: pergolide
Target: 5-hydroxytryptamine receptor 1A (GPCR)
Gene: HTR1A
UniProt: P08908 (5HT1A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.5
Drug: pergolide
Target: 5-hydroxytryptamine receptor 2A (GPCR)
Gene: HTR2A
UniProt: P28223 (5HT2A_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 8.1
Drug: pergolide
Target: 5-hydroxytryptamine receptor 2B (GPCR)
Gene: HTR2B
UniProt: P41595 (5HT2B_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 8.2
Drug: pergolide
Target: 5-hydroxytryptamine receptor 2C (GPCR)
Gene: HTR2C
UniProt: P28335 (5HT2C_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 6.5
Drug: pergolide
Target: 5-hydroxytryptamine receptor 6 (GPCR)
Gene: HTR6
UniProt: P50406 (5HT6R_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.75
Assay: DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT6 radioligand binding (ligand: [3H] Lysergic acid diethylamide)