AIM-Harvard/TrialPanorama-filtered huggingface dataset:
Drug: raloxifene
Target: Acetylcholinesterase (Enzyme)
Gene: ACHE
UniProt: P22303 (ACES_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.398
Assay: DRUGMATRIX: Acetylcholinesterase enzyme inhibition (substrate: acetylthiocholine)
Drug: raloxifene
Target: Cytochrome P450 2C9 (Enzyme)
Gene: CYP2C9
UniProt: P11712 (CP2C9_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.699
Assay: DRUGMATRIX: CYP450, 2C9 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)
Drug: raloxifene
Target: Estrogen receptor beta (Nuclear hormone receptor)
Gene: ESR2
UniProt: Q92731 (ESR2_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 8
Action type: MODULATOR
Drug: raloxifene
Target: G-protein coupled estrogen receptor 1 (GPCR)
Gene: GPER1
UniProt: Q99527 (GPER1_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 6.5
Drug: raloxifene
Target: Interleukin-6 (Cytokine)
Gene: IL6
UniProt: P05231 (IL6_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 8.05
Drug: raloxifene
Target: Tyrosine-protein kinase Fyn (Kinase)
Gene: FYN
UniProt: P06241 (FYN_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.436
Assay: DRUGMATRIX: Protein Tyrosine Kinase, Fyn enzyme inhibition (substrate: Poly(Glu:Tyr))
Drug: raloxifene
Target: Bile acid receptor (Nuclear hormone receptor)
Gene: NR1H4
UniProt: Q96RI1 (NR1H4_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.94
Assay: Antagonist activity at human GTS-tagged FXR after 20 mins by TR-FRET assay
Drug: raloxifene
Target: Substance-K receptor (GPCR)
Gene: TACR2
UniProt: P21452 (NK2R_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.876
Assay: DRUGMATRIX: Tachykinin NK2  radioligand binding (ligand: [3H] SR-48968)
Drug: raloxifene
Target: Phospholipase D1 (Enzyme)
Gene: PLD1
UniProt: Q13393 (PLD1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.4
Assay: Inhibition of human PLD1b
Drug: raloxifene
Target: Phospholipase D2 (Enzyme)
Gene: PLD2
UniProt: O14939 (PLD2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.47
Assay: Inhibition of human PLD2 assessed as release of methyl-[3H]choline from choline-methyl-[3H]dipalmitoylphosphatidylcholine after 30 mins by exogenous substrate assay
Drug: raloxifene
Target: Alpha-1B adrenergic receptor (GPCR)
Gene: Adra1b
UniProt: P15823 (ADA1B_RAT)
Organism: Rattus norvegicus
Activity: Ki = 5.827
Assay: DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
Drug: raloxifene
Target: 5-hydroxytryptamine receptor 1B (GPCR)
Gene: Htr1b
UniProt: P28564 (5HT1B_RAT)
Organism: Rattus norvegicus
Activity: Ki = 6.073
Assay: DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)
Drug: raloxifene
Target: Membrane-associated progesterone receptor component 1 (Membrane receptor)
Gene: Pgrmc1
UniProt: P70580 (PGRC1_RAT)
Organism: Rattus norvegicus
Activity: Ki = 6.625
Assay: DRUGMATRIX: Sigma2 radioligand binding (ligand: [3H] Ifenprodil)
Drug: raloxifene
Target: Alpha-1A adrenergic receptor (GPCR)
Gene: Adra1a
UniProt: P43140 (ADA1A_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 5.66
Drug: raloxifene
Target: Estrogen receptor (Transcription factor)
Gene: Esr1
UniProt: P06211 (ESR1_RAT)
Organism: Rattus norvegicus
Activity: Ki = 9.43
Assay: Binding affinity for rat estrogen receptor alpha
Drug: raloxifene
Target: Estrogen receptor beta (Transcription factor)
Gene: Esr2
UniProt: Q62986 (ESR2_RAT)
Organism: Rattus norvegicus
Activity: Ki = 8.56
Assay: Binding affinity for rat estrogen receptor beta
Drug: raloxifene
Target: C-8 sterol isomerase (Enzyme)
Gene: ERG2
UniProt: P32352 (ERG2_YEAST)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Activity: Ki = 7.18
Assay: Affinity for ERG2 of Saccharomyces cerevisiae using [3H]ifenprodil or (+)-[3H]pentazocine radioligand
Drug: raloxifene
Target: Cruzipain (Enzyme)
UniProt: P25779 (CYSP_TRYCR)
Organism: Trypanosoma cruzi
Activity: IC50 = 4.48
Assay: Inhibition of Trypanosoma cruzi cruzaine preincubated for 5 mins before substrate addition by fluorescence assay in absence of Triton X-100
Drug: raloxifene
Target: Estrogen receptor (Transcription factor)
Gene: Esr1|Esr2
UniProt: P06211|Q62986 (ESR1_RAT|ESR2_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 8.73
Assay: Inhibition of estradiol binding to estrogen receptor
Drug: raloxifene
Target: Complement C5 (Secreted)
Gene: C5
UniProt: P01031 (CO5_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.15
Assay: Binding affinity to human C5a assessed as dissociation constant after 1 hr by circular dichroism analysis
Drug: raloxifene
Target: HLA class I histocompatibility antigen, A-3 alpha chain (Unclassified)
Gene: HLA-A
UniProt: P04439 (1A03_HUMAN)
Organism: Homo sapiens
Activity: Kd = 4.66
Assay: Binding affinity to human biotinylated HLA-A2 by surface plasmon resonance assay
Drug: raloxifene
Target: Complement C5 (Unclassified)
Gene: C5
UniProt: P01031 (CO5_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.15
Assay: Binding affinity to human C5a assessed as dissociation constant after 1 hr by circular dichroism analysis
Drug: raltegravir
Target: Gag-Pol polyprotein (Polyprotein)
Gene: gag-pol
UniProt: P03367 (POL_HV1BR)
Organism: Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI)
Activity: IC50 = 7.523
Action type: INHIBITOR
Drug: raltegravir
Target: Integrase (Enzyme)
Gene: pol
UniProt: Q7ZJM1 (Q7ZJM1_9HIV1)
Organism: Human immunodeficiency virus 1
Activity: IC50 = 8
Action type: INHIBITOR
Assay: Inhibition of HIV-1 overall integrase activity using 5'-digoxigenin-labeled GACCCTTTTAGTCAGTGTGGAAAATCTCTAGCAGT-3' as substrate after 1 hr by ELISA
Drug: raltegravir
Target: C-C chemokine receptor type 1 (GPCR)
Gene: CCR1
UniProt: P32246 (CCR1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.3
Assay: Binding affinity to CCR1
Drug: raltegravir
Target: Integrase (Enzyme)
UniProt: Q76353 (Q76353_9HIV1)
Organism: Human immunodeficiency virus 1
Activity: IC50 = 5.74
Drug: raltitrexed
Target: Thymidylate synthase (Enzyme)
Gene: TYMS
UniProt: P04818 (TYSY_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.59
Assay: Inhibition of human recombinant His-tagged thymidylate synthase assessed as N5,N10-methylenetetrahydrofolate oxidation to dihydrofolate after 20 mins by UV spectrophotometric analysis
Drug: raltitrexed
Target: Dihydrofolate reductase (Enzyme)
Gene: DHFR
UniProt: P00374 (DYR_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.678
Drug: raltitrexed
Target: Bifunctional dihydrofolate reductase-thymidylate synthase (Enzyme)
UniProt: Q07422 (DRTS_TOXGO)
Organism: Toxoplasma gondii
Activity: IC50 = 6.32
Assay: Inhibition of Toxoplasma gondii thymidylate synthase
Drug: raltitrexed
Target: Folate receptor beta (Membrane receptor)
Gene: FOLR2
UniProt: P14207 (FOLR2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7.66
Drug: raltitrexed
Target: Proton-coupled folate transporter (Transporter)
Gene: SLC46A1
UniProt: Q96NT5 (PCFT_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7
Drug: raltitrexed
Target: Thymidylate synthase (Enzyme)
Gene: thyA
UniProt: P0A884 (TYSY_ECOLI)
Organism: Escherichia coli (strain K12)
Activity: IC50 = 5.244
Drug: raltitrexed
Target: Thymidylate synthase (Enzyme)
Gene: Tyms
UniProt: P07607 (TYSY_MOUSE)
Organism: Mus musculus
Activity: Ki = 6.38
Assay: Compound was evaluated for inhibition of thymidylate synthase, partially purified from L1210 mouse leukemia cells that overproduce thymidylate synthase due to amplification of TS gene
Drug: raltitrexed
Target: Thymidylate synthase (Enzyme)
Gene: Tyms
UniProt: P45352 (TYSY_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 6.05
Assay: Inhibitory concentration against isolated rat thymidylate synthase
Drug: raltitrexed
Target: Thymidylate synthase (Enzyme)
Gene: thyA
UniProt: P00469 (TYSY_LACCA)
Organism: Lactobacillus casei
Activity: IC50 = 5.1
Assay: Compound was evaluated as inhibitor of Lactobacillus casei thymidylate synthase
Drug: raltitrexed
Target: Dihydrofolate reductase (Enzyme)
Gene: dfrA17
UniProt: B0BL08 (B0BL08_ECOLX)
Organism: Escherichia coli
Activity: IC50 = 4.64
Assay: Inhibition of Escherichia coli DHFR
Drug: raltitrexed
Target: Thymidylate synthase (Enzyme)
Gene: thyA
UniProt: C3SWJ7 (C3SWJ7_ECOLX)
Organism: Escherichia coli
Activity: IC50 = 5.28
Assay: The inhibitory concentration of compound was evaluated on Escherichia coli thymidylate synthase
Drug: raltitrexed
Target: Folate transporter 1 (Transporter)
Gene: SLC19A1
UniProt: P41440 (S19A1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 8.2
Drug: raltitrexed
Target: Folate receptor alpha (Membrane receptor)
Gene: FOLR1
UniProt: P15328 (FOLR1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7.82
Drug: ramatroban
Target: Prostaglandin D2 receptor 2 (GPCR)
Gene: PTGDR2
UniProt: Q9Y5Y4 (PD2R2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.37
Assay: Inhibition of [3H]PGD-2 binding to human chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2)
Drug: ramatroban
Target: Thromboxane A2 receptor (GPCR)
Gene: TBXA2R
UniProt: P21731 (TA2R_HUMAN)
Organism: Homo sapiens
Activity: Ki = 9.24
Action type: INVERSE AGONIST
Assay: Binding affinity to thromboxane receptor
Drug: ramatroban
Target: Prostaglandin D2 receptor (GPCR)
Gene: PTGDR
UniProt: Q13258 (PD2R_HUMAN)
Organism: Homo sapiens
Activity: Ki = 4.96
Assay: Binding affinity to prostanoid DP1 receptor
Drug: ramatroban
Target: Prostaglandin D2 receptor 2 (GPCR)
Gene: Ptgdr2
UniProt: Q6XKD3 (PD2R2_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 7.3
Action type: ANTAGONIST
Drug: ramatroban
Target: Prostaglandin D2 receptor 2 (GPCR)
Gene: Ptgdr2
UniProt: Q9Z2J6 (PD2R2_MOUSE)
Organism: Mus musculus
Activity: Ki = 7.3
Action type: ANTAGONIST
Drug: ramelteon
Target: Melatonin receptor type 1A (GPCR)
Gene: MTNR1A
UniProt: P48039 (MTR1A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 10.9
Action type: AGONIST
Drug: ramelteon
Target: Melatonin receptor type 1B (GPCR)
Gene: MTNR1B
UniProt: P49286 (MTR1B_HUMAN)
Organism: Homo sapiens
Activity: Ki = 10.39
Action type: AGONIST
Drug: ramipril
Target: Angiotensin-converting enzyme (Enzyme)
Gene: ACE
UniProt: P12821 (ACE_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.342
Action type: INHIBITOR
Drug: ramipril
Target: Angiotensin-converting enzyme (Enzyme)
Gene: ACE
UniProt: P12822 (ACE_RABIT)
Organism: Oryctolagus cuniculus
Activity: IC50 = 6.6
Assay: Inhibition of rabbit lung ACE assessed as hydrolysis of hippuryl-histidyl-leucine to hippuric acid and histidyl-leucine after 30 mins
Drug: ramosetron
Target: 5-hydroxytryptamine receptor 3A (Ion channel)
Gene: HTR3A
UniProt: P46098 (5HT3A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 10.22
Action type: ANTAGONIST
Assay: Binding affinity to human 5HT3A receptor
Drug: ranitidine
Target: Histamine H2 receptor (GPCR)
Gene: HRH2
UniProt: P25021 (HRH2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.86
Action type: ANTAGONIST
Drug: ranitidine
Target: Acetylcholinesterase (Enzyme)
Gene: ACHE
UniProt: P22303 (ACES_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.19
Assay: Inhibition of guinea pig acetylcholinesterase
Drug: ranitidine
Target: Histamine H2 receptor (GPCR)
Gene: HRH2
UniProt: P47747 (HRH2_CAVPO)
Organism: Cavia porcellus
Activity: Kd = 7.19
Assay: Compound was evaluated in vitro inhibitory activity against histamine H2 receptor in isolated Guinea pig right atria.
Drug: ranitidine
Target: Multidrug and toxin extrusion protein 1 (Transporter)
Gene: SLC47A1
UniProt: Q96FL8 (S47A1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.08
Assay: Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay
Drug: ranitidine
Target: Histamine H2 receptor (GPCR)
Gene: Hrh2
UniProt: P25102 (HRH2_RAT)
Organism: Rattus norvegicus
Activity: Ki = 6.2
Action type: ANTAGONIST
Drug: ranolazine
Target: Sodium channel protein type 5 subunit alpha (Ion channel)
Gene: SCN5A
UniProt: Q14524 (SCN5A_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.17
Action type: BLOCKER
Assay: Inhibition of human NaV1.5 expressed in HEK293 cells assessed as blocking of tefluthrin-induced late sodium currents using -20 mV voltage steps at holding potential of -120 mV by whole cell patch clamp Qpatch method
Drug: ranolazine
Target: Potassium voltage-gated channel subfamily H member 2 (Ion channel)
Gene: KCNH2
UniProt: Q12809 (KCNH2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.921
Drug: ranolazine
Target: Multidrug resistance protein 1 (Transporter)
Gene: ABCB1
UniProt: P08183 (MDR1_HUMAN)
Organism: Homo sapiens
Drug: ranolazine
Target: Voltage-gated sodium channel Nav1.5 cardiac isoform (Unclassified)
Gene: SCN5A
UniProt: Q5YLN7 (Q5YLN7_CANLF)
Organism: Canis lupus familiaris
Activity: IC50 = 5.16
Assay: Inhibition of canine ventricular myocytes Nav 1.5 assessed as reduction in ATX-2 induced late channel current by manual single-patch clamp assay
Drug: rebamipide
Target: Cholecystokinin receptor type A (GPCR)
Gene: Cckar
UniProt: P30551 (CCKAR_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 4.4
Action type: AGONIST
Drug: reboxetine
Target: Sodium-dependent serotonin transporter (Transporter)
Gene: SLC6A4
UniProt: P31645 (SC6A4_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.05
Assay: In vitro competitive binding versus [3H]-citalopram in murine kidney cells transfected with cDNA for human serotonin transporter (SERT)
Drug: reboxetine
Target: Sodium-dependent noradrenaline transporter (Transporter)
Gene: SLC6A2
UniProt: P23975 (SC6A2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.96
Assay: In vitro binding affinity against human norepinephrine transporter in human embryonic kidney cell line by using [3H]-nisoxatine radioligand
Drug: reboxetine
Target: 5-hydroxytryptamine receptor 2C (GPCR)
Gene: HTR2C
UniProt: P28335 (5HT2C_HUMAN)
Organism: Homo sapiens
Activity: Ki  6.34
Drug: reboxetine
Target: 5-hydroxytryptamine receptor 6 (GPCR)
Gene: HTR6
UniProt: P50406 (5HT6R_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.34
Drug: reboxetine
Target: Sodium-dependent dopamine transporter (Transporter)
Gene: SLC6A3
UniProt: Q01959 (SC6A3_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.22
Assay: In vitro competitive binding versus [N-methyl-3H]WIN-35428 in murine kidney cells transfected with cDNA for human dopamine transporter (DAT)
Drug: reboxetine
Target: G protein-activated inward rectifier potassium channel 2 (Ion channel)
Gene: KCNJ6
UniProt: P48051 (KCNJ6_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.194
Drug: reboxetine
Target: Sodium-dependent serotonin transporter (Transporter)
Gene: Slc6a4
UniProt: P31652 (SC6A4_RAT)
Organism: Rattus norvegicus
Activity: Ki = 6.3
Assay: Inhibition of SERT in rat cerebral cortex assessed as [3H]serotonin accumulation
Drug: reboxetine
Target: Transporter (Transporter)
Gene: Slc6a2
UniProt: Q9WTR4 (Q9WTR4_RAT)
Organism: Rattus norvegicus
Activity: Ki = 7.86
Assay: Binding affinity against norepinephrine transporter (NET) by displacement of [3H]nisoxetine in male wistar rats
Drug: reboxetine
Target: Transporter (Transporter)
Gene: NET
UniProt: Q63380 (Q63380_RAT)
Organism: Rattus norvegicus
Activity: Ki = 9.16
Assay: Displacement of [3H]-dopamine from rat cerebral cortex NET after 7 mins
Drug: reboxetine
Target: Kir3.1/Kir3.2 (Ion channel)
Gene: KCNJ6|KCNJ3
UniProt: P48051|P48549 (KCNJ6_HUMAN|KCNJ3_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.317
Drug: reboxetine
Target: Kir3.1/Kir3.4 (Ion channel)
Gene: KCNJ5|KCNJ3
UniProt: P48544|P48549 (KCNJ5_HUMAN|KCNJ3_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.387
Drug: regadenoson
Target: Adenosine receptor A2a (GPCR)
Gene: ADORA2A
UniProt: P29274 (AA2AR_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 5.886
Action type: AGONIST
Drug: regadenoson
Target: Adenosine receptor A1 (GPCR)
Gene: ADORA1
UniProt: P30542 (AA1R_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 4.398
Drug: regadenoson
Target: Adenosine receptor A2b (GPCR)
Gene: ADORA2B
UniProt: P29275 (AA2BR_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 5
Assay: Agonist activity at human recombinant adenosine receptor A2b by cAMP assay
Drug: regadenoson
Target: Adenosine receptor A3 (GPCR)
Gene: ADORA3
UniProt: P0DMS8 (AA3R_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5
Assay: Binding affinity to human recombinant adenosine A3 receptor
Drug: regadenoson
Target: Adenosine receptor A2a (GPCR)
Gene: Adora2a
UniProt: P30543 (AA2AR_RAT)
Organism: Rattus norvegicus
Activity: Ki = 6.54
Assay: Receptor binding affinity for the adenosine A2A receptor was determined using [3H]ZM-241385 as a radioligand in rat
Drug: remifentanil
Target: Mu-type opioid receptor (GPCR)
Gene: OPRM1
UniProt: P35372 (OPRM_HUMAN)
Organism: Homo sapiens
Action type: AGONIST
Drug: remifentanil
Target: Mu-type opioid receptor (GPCR)
Gene: Oprm1
UniProt: P33535 (OPRM_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 9.22
Assay: Displacement of [3H]DAMGO from rat brain mu opioid receptor incubated for 60 mins by microbeta scintillation counting method
Drug: remoxipride
Target: D(2) dopamine receptor (GPCR)
Gene: DRD2
UniProt: P14416 (DRD2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.06
Action type: ANTAGONIST
Assay: Binding affinity to dopamine receptor D2 cloned from human, using [3H]- YM09151 as competitive ligand
Drug: remoxipride
Target: Sigma non-opioid intracellular receptor 1 (Membrane receptor)
Gene: SIGMAR1
UniProt: Q99720 (SGMR1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.26
Assay: Binding affinity against the sigma receptor from guinea pig brain using the radioligand [3H]SKF-10047
Drug: remoxipride
Target: 5-hydroxytryptamine receptor 1A (GPCR)
Gene: HTR1A
UniProt: P08908 (5HT1A_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.4
Assay: Binding affinity to 5HT1A receptor
Drug: remoxipride
Target: 5-hydroxytryptamine receptor 2A (GPCR)
Gene: HTR2A
UniProt: P28223 (5HT2A_HUMAN)
Organism: Homo sapiens
Activity: Ki  5.509
Drug: remoxipride
Target: D(3) dopamine receptor (GPCR)
Gene: DRD3
UniProt: P35462 (DRD3_HUMAN)
Organism: Homo sapiens
Activity: Ki  7.155
Drug: remoxipride
Target: D(4) dopamine receptor (GPCR)
Gene: DRD4
UniProt: P21917 (DRD4_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.41
Assay: Displacement of [3H]-YM 09151 from human Dopamine receptor D4
Drug: remoxipride
Target: D(2) dopamine receptor (GPCR)
Gene: Drd2
UniProt: P61169 (DRD2_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 5.85
Assay: Binding affinity against the Dopamine receptor D2 in rat striatnrn by using [3H]spiperone radioligand
Drug: remoxipride
Target: D(2) dopamine receptor (GPCR)
Gene: DRD2
UniProt: P52702 (DRD2_CHLAE)
Organism: Chlorocebus aethiops
Activity: Ki = 6.06
Assay: Displacement of [3H]-YM 09151 from african green monkey Dopamine receptor D2
Drug: remoxipride
Target: D(3) dopamine receptor (GPCR)
Gene: DRD3
UniProt: P52703 (DRD3_CHLAE)
Organism: Chlorocebus aethiops
Activity: Ki = 5.34
Assay: Displacement of [3H]-YM 09151 from african monkey Dopamine receptor D3
Drug: remoxipride
Target: Dopamine receptor (GPCR)
Gene: Drd1|Drd3|Drd5|Drd4|Drd2
UniProt: P18901|P19020|P25115|P30729|P61169 (DRD1_RAT|DRD3_RAT|DRD5_RAT|DRD4_RAT|DRD2_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 5.8
Assay: Antidopamine activity in vitro by ability to displace [3H]spiperone from rat brain striatal preparations.
Drug: repaglinide
Target: ATP-binding cassette sub-family C member 8 (Ion channel)
Gene: ABCC8
UniProt: Q09428 (ABCC8_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.3
Assay: Displacement of [3H]glibenclamide from COS-1 cells expressing Sulfonylurea receptor 1 (SUR-1)
Drug: repaglinide
Target: Solute carrier organic anion transporter family member 1B1 (Transporter)
Gene: SLCO1B1
UniProt: Q9Y6L6 (SO1B1_HUMAN)
Organism: Homo sapiens
Drug: repaglinide
Target: Solute carrier family 22 member 1 (Transporter)
Gene: SLC22A1
UniProt: O15245 (S22A1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.04
Assay: Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells by confocal microscopy
Drug: repaglinide
Target: Sulfonylurea receptor 1, Kir6.2 (Ion channel)
Gene: ABCC8|KCNJ11
UniProt: Q09428|Q14654 (ABCC8_HUMAN|KCJ11_HUMAN)
Organism: Homo sapiens
Activity: Ki = 9.14
Action type: BLOCKER
Drug: repaglinide
Target: Sulfonylurea receptor 2, Kir6.2 (Ion channel)
Gene: ABCC9|KCNJ11
UniProt: O60706|Q14654 (ABCC9_HUMAN|KCJ11_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.81
Action type: BLOCKER
Drug: reproterol
Target: Beta-2 adrenergic receptor (GPCR)
Gene: ADRB2
UniProt: P07550 (ADRB2_HUMAN)
Organism: Homo sapiens
Action type: AGONIST
Assay: Mechanism of Action
Drug: rescinnamine
Target: Synaptic vesicular amine transporter (Transporter)
Gene: SLC18A2
UniProt: Q05940 (VMAT2_HUMAN)
Organism: Homo sapiens
Action type: INHIBITOR
Assay: Mechanism of Action; CHEMBL1893; SINGLE PROTEIN
Drug: reserpine
Target: Mu-type opioid receptor (GPCR)
Gene: OPRM1
UniProt: P35372 (OPRM_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.773
Assay: DRUGMATRIX: Opiate mu (OP3, MOP) radioligand binding (ligand: [3H] Diprenorphine)
Drug: reserpine
Target: D(1A) dopamine receptor (GPCR)
Gene: DRD1
UniProt: P21728 (DRD1_HUMAN)
Organism: Homo sapiens
Activity: Ki  5.415
Drug: reserpine
Target: D(2) dopamine receptor (GPCR)
Gene: DRD2
UniProt: P14416 (DRD2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.232
Drug: reserpine
Target: Multidrug resistance protein 1 (Transporter)
Gene: ABCB1
UniProt: P08183 (MDR1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7
Assay: Concentration giving half of the maximal ATPase activity calculated for the high-affinity binding site of the CHO P-Glycoprotein (P-gp) in two-affinity model
Drug: reserpine
Target: 5-hydroxytryptamine receptor 1A (GPCR)
Gene: HTR1A
UniProt: P08908 (5HT1A_HUMAN)
Organism: Homo sapiens
Activity: Ki  5.737
Drug: reserpine
Target: D(3) dopamine receptor (GPCR)
Gene: DRD3
UniProt: P35462 (DRD3_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.223
Drug: reserpine
Target: ATP-binding cassette sub-family G member 2 (Transporter)
Gene: ABCG2
UniProt: Q9UNQ0 (ABCG2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.58
Assay: Inhibition of ABCG2 in human mitoxantrone-resistant MCF7 cells by Hoechst 33342 assay
Drug: reserpine
Target: Synaptic vesicular amine transporter (Transporter)
Gene: SLC18A2
UniProt: Q05940 (VMAT2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.9
Action type: INHIBITOR
Drug: reserpine
Target: Synaptic vesicular amine transporter (Transporter)
Gene: SLC18A2
UniProt: Q27963 (VMAT2_BOVIN)
Organism: Bos taurus
Activity: Ki = 9
Assay: Inhibition of dopamine uptake at VMAT in bovine chromaffin granule ghosts
Drug: reserpine
Target: Quinolone resistance protein NorA (Transporter)
Gene: norA
UniProt: P0A0J7 (NORA_STAAU)
Organism: Staphylococcus aureus
Activity: IC50 = 5.15
Assay: Inhibition of NorA in Staphylococcus aureus 1199B assessed as inhibition of ethidium bromide efflux dose response curve based fluorometric assay
Drug: reserpine
Target: Chromaffin granule amine transporter (Transporter)
Gene: SLC18A1
UniProt: P54219 (VMAT1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.45
Action type: INHIBITOR
Drug: reserpine
Target: Sodium channel alpha subunits; brain (Types I, II, III) (Ion channel)
Gene: SCN1A|SCN2A|SCN3A
UniProt: P35498|Q99250|Q9NY46 (SCN1A_HUMAN|SCN2A_HUMAN|SCN3A_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.8
Assay: Inhibition of binding of Batrachotoxinin [3H]BTX-B to high affinity sites on voltage dependent sodium channels in a vesicular preparation from guinea pig cerebral cortex
Drug: reserpine
Target: Synaptic vesicular amine transporter (Transporter)
Gene: Slc18a2
UniProt: Q8BRU6 (VMAT2_MOUSE)
Organism: Mus musculus
Activity: IC50 = 8.75
Assay: Inhibition of VMAT2 in C57Bl/6J mouse striatal membranes assessed as reduction in [3H[-5HT uptake pre-incubated for 10 mins before [3H[-5HT addition and measured after 8 mins
Drug: reserpine
Target: Sodium-dependent serotonin transporter (Transporter)
Gene: SLC6A4
UniProt: P31645 (SC6A4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.836
Drug: retinol acetate
Target: Retinol-binding protein 4 (Secreted)
Gene: RBP4
UniProt: P02753 (RET4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.74
Assay: Binding affinity to His-tagged recombinant human sRBP expressed in Escherichia coli BL21(DE3) assessed as apparent dissociation constant after 5 mins by fluorescence spectrophotometric analysis
Drug: retinol acetate
Target: Beta-lactoglobulin (Unclassified)
Gene: LGB
UniProt: P02754 (LACB_BOVIN)
Organism: Bos taurus
Activity: Kd = 7.44