AIM-Harvard/TrialPanorama-filtered huggingface dataset:
Drug: citalopram
Target: 5-hydroxytryptamine receptor 1A (GPCR)
Gene: Htr1a
UniProt: P19327 (5HT1A_RAT)
Organism: Rattus norvegicus
Activity: Ki = 4.3
Drug: citalopram
Target: Sodium-dependent serotonin transporter (Transporter)
Gene: Slc6a4
UniProt: P31652 (SC6A4_RAT)
Organism: Rattus norvegicus
Activity: Ki = 8.82
Assay: Inhibition of [3H]citalopram binding to Serotonin transporter of rat cerebral cortex
Drug: citalopram
Target: Sodium-dependent dopamine transporter (Transporter)
Gene: Slc6a3
UniProt: P23977 (SC6A3_RAT)
Organism: Rattus norvegicus
Activity: Ki = 5.03
Assay: Displacement of [3H]WIN-35428 from DAT in rat caudate-putamen by scintillation counting
Drug: citalopram
Target: Transporter (Transporter)
Gene: Slc6a2
UniProt: Q9WTR4 (Q9WTR4_RAT)
Organism: Rattus norvegicus
Activity: Ki = 5.21
Assay: Displacement of [3H]nisoxetine from norepinephrine transporter of rat cerebral cortex
Drug: citalopram
Target: Sodium-dependent dopamine transporter (Transporter)
Gene: Slc6a3
UniProt: Q61327 (SC6A3_MOUSE)
Organism: Mus musculus
Activity: Ki = 8.54
Assay: Tested in vitro for serotonin(5-HT) neuronal uptake inhibition
Drug: citalopram
Target: Transporter (Transporter)
Gene: NET
UniProt: Q63380 (Q63380_RAT)
Organism: Rattus norvegicus
Activity: Ki = 5.23
Assay: Displacement of [3H]nisoxetine from NET in rat frontal cortex by scintillation counting
Drug: citric acid
Target: 3-dehydroquinate dehydratase (Enzyme)
Gene: aroQ
UniProt: Q48255 (AROQ_HELPY)
Organism: Helicobacter pylori (strain ATCC 700392 / 26695)
Activity: Kd = 5.6
Assay: Binding affinity for Helicobacter pylori DHQase 2
Drug: citric acid
Target: 3-dehydroquinate dehydratase (Enzyme)
Gene: aroQ
UniProt: P15474 (AROQ_STRCO)
Organism: Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Activity: Kd = 5.14
Assay: Binding affinity for Streptomyces coelicolor DHQase 2
Drug: citric acid
Target: Transient receptor potential cation channel subfamily V member 4 (Ion channel)
Gene: Trpv4
UniProt: Q9EPK8 (TRPV4_MOUSE)
Organism: Mus musculus
Activity: EC50 = 5.6
Action type: ACTIVATOR
Drug: cladribine
Target: Deoxycytidine kinase (Kinase)
Gene: DCK
UniProt: P27707 (DCK_HUMAN)
Organism: Homo sapiens
Drug: cladribine
Target: cAMP-specific 3',5'-cyclic phosphodiesterase 4A (Enzyme)
Gene: PDE4A
UniProt: P27815 (PDE4A_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.441
Assay: DRUGMATRIX: Phosphodiesterase PDE4 enzyme inhibition (substrate: [3H]cAMP + cAMP)
Drug: cladribine
Target: Adenosine receptor A1 (GPCR)
Gene: Adora1
UniProt: P25099 (AA1R_RAT)
Organism: Rattus norvegicus
Activity: Ki = 5.14
Assay: Binding affinity to adenosine A1 receptor in rat brain membranes by measuring displacement of specific [3H]PIA as radioligand.
Drug: cladribine
Target: Adenosine receptor A2a (GPCR)
Gene: Adora2a
UniProt: P30543 (AA2AR_RAT)
Organism: Rattus norvegicus
Activity: Ki = 4.69
Assay: Binding affinity to adenosine A2A receptor in rat striatal membranes by measuring displacement of specific [3H]-CGS- 21680 as radioligand
Drug: clarithromycin
Target: Potassium voltage-gated channel subfamily H member 2 (Ion channel)
Gene: KCNH2
UniProt: Q12809 (KCNH2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.23
Drug: clavulanic acid
Target: Beta-lactamase (Enzyme)
Gene: blaZ
UniProt: P00807 (BLAC_STAAU)
Organism: Staphylococcus aureus
Activity: MPC = 8.719
Drug: clavulanic acid
Target: Beta-lactamase TEM (Enzyme)
Gene: bla; blaT-3; blaT-4;
UniProt: P62593 (BLAT_ECOLX)
Organism: Escherichia coli
Activity: IC50 = 10.187
Action type: INHIBITOR
Drug: clavulanic acid
Target: Beta-lactamase (Enzyme)
Gene: ampC
UniProt: P00811 (AMPC_ECOLI)
Organism: Escherichia coli (strain K12)
Activity: IC50 = 7.82
Assay: Inhibitory activity against Escherichia coli TEM-3 Beta-lactamase
Drug: clavulanic acid
Target: Beta-lactamase (Enzyme)
UniProt: Q59401 (Q59401_ENTCL)
Organism: Enterobacter cloacae
Activity: IC50 = 4
Assay: The compound was tested for its inhibitory activity towards Class C beta-lactamase from Enterobacter cloacae 908R at 0.8 umol concentration
Drug: clavulanic acid
Target: Beta-lactamase SHV-1 (Enzyme)
Gene: bla
UniProt: P0AD63 (BLA1_ECOLX)
Organism: Escherichia coli
Activity: IC50 = 7.55
Assay: Inhibition of Escherichia coli SHV1
Drug: clavulanic acid
Target: Beta-lactamase (Enzyme)
Gene: ampC
UniProt: P05364 (AMPC_ENTCL)
Organism: Enterobacter cloacae
Activity: Kd = 6.4
Assay: Kd for TEM-1 beta-lactamase
Drug: clavulanic acid
Target: Beta-lactamase OXA-1 (Enzyme)
Gene: bla
UniProt: P13661 (BLO1_ECOLX)
Organism: Escherichia coli
Activity: IC50 = 5.49
Assay: Inhibitory activity against Beta-lactamase type OXA1 (penicillinase) from Escherichia coli OXA1 using ampicillin (40 uM) as a substrate
Drug: clavulanic acid
Target: Beta-lactamase (Enzyme)
Gene: ampC
UniProt: P24735 (AMPC_PSEAE)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Activity: IC50 = 6.1
Assay: Inhibitory concentration was evaluated as concentration required for 50% inhibition of Pseudomonas aeruginosa 18SH Beta-lactamase
Drug: clavulanic acid
Target: Beta-lactamase (Enzyme)
Gene: BlaGIL-1
UniProt: A4KCT8 (A4KCT8_9ENTR)
Organism: Citrobacter gillenii
Activity: IC50 = 8.05
Assay: Inhibition of Citrobacter gillenii CIP 106783 Beta-lactamase GIL1 expressed in Escherichia coli DH10B
Drug: clavulanic acid
Target: Beta-lactamase (Enzyme)
Gene: blaSCO-1
UniProt: A1E3K9 (A1E3K9_ECOLX)
Organism: Escherichia coli
Activity: IC50 = 7.15
Assay: Inhibition of Escherichia coli beta-lactamase SCO1
Drug: clavulanic acid
Target: Beta-lactamase (Enzyme)
Gene: bcl1
UniProt: A8RR46 (A8RR46_BACCS)
Organism: Bacillus clausii
Activity: IC50 = 7.07
Assay: Inhibition of Bacillus clausii NR beta-lactamase BCL1 expressed in Escherichia coli BL21 (DE3)
Drug: clavulanic acid
Target: Carbapenem-hydrolizing beta-lactamase SFC-1 (Enzyme)
UniProt: Q6JP75 (Q6JP75_SERFO)
Organism: Serratia fonticola
Activity: IC50 = 4.14
Assay: Inhibition of Serratia fonticola UTAD54 SFC1 beta lactamase expressed in Escherichia coli BL21(DE3) by SDS-PAGE
Drug: clavulanic acid
Target: Carbepenem-hydrolyzing beta-lactamase KPC (Enzyme)
Gene: bla
UniProt: Q9F663 (BLKPC_KLEPN)
Organism: Klebsiella pneumoniae
Activity: Ki = 4.96
Assay: Inhibition of Klebsiella pneumoniae 1534 beta-lactamase KPC-2 by competitive assay
Drug: clavulanic acid
Target: Beta-lactamase (Enzyme)
Gene: blaPER-2
UniProt: A2RP81 (A2RP81_CITFR)
Organism: Citrobacter freundii
Activity: IC50 = 7.17
Assay: Inhibition of Citrobacter freundii PER2 beta lactamase
Drug: clavulanic acid
Target: Beta-lactamase (Enzyme)
Gene: blaUOE-1
UniProt: Q9EXV5 (Q9EXV5_ECOLX)
Organism: Escherichia coli
Activity: IC50 = 8.05
Assay: Inhibition of Escherichia coli CTX-M-15
Drug: clavulanic acid
Target: Beta-lactamase SHV-1 (Enzyme)
Gene: bla
UniProt: P0AD64 (BLA1_KLEPN)
Organism: Klebsiella pneumoniae
Activity: IC50 = 6.77
Assay: Inhibition of Klebsiella pneumoniae Beta-Lactamase SHV-1
Drug: clavulanic acid
Target: Beta-lactamase (Enzyme)
Gene: blaTEM-125
UniProt: Q6GWS8 (Q6GWS8_ECOLX)
Organism: Escherichia coli
Activity: IC50 = 5.07
Assay: Inhibition of Escherichia coli DH5alpha beta-lactamase TEM-158
Drug: clavulanic acid
Target: Beta-lactamase GES-13 (Enzyme)
Gene: blaGES-13
UniProt: D1MIX9 (D1MIX9_PSEAI)
Organism: Pseudomonas aeruginosa
Activity: IC50 = 7
Assay: Inhibition of Pseudomonas aeruginosa GES-13 beta lactamase
Drug: clavulanic acid
Target: Beta-lactamase (Enzyme)
Gene: blaSHV-72
UniProt: A0ZX81 (A0ZX81_KLEPN)
Organism: Klebsiella pneumoniae
Activity: IC50 = 5.76
Assay: Inhibition of Klebsiella pneumoniae Beta-Lactamase SHV-72
Drug: clavulanic acid
Target: Beta-lactamase (Enzyme)
Gene: blaSHV-55
UniProt: Q4TVR4 (Q4TVR4_KLEPN)
Organism: Klebsiella pneumoniae
Activity: IC50 = 7.7
Assay: Inhibition of Klebsiella pneumoniae Beta-Lactamase SHV-55
Drug: clavulanic acid
Target: Class D beta-lactamase (Unclassified)
Gene: oxa-63
UniProt: Q50H31 (Q50H31_BRAPL)
Organism: Brachyspira pilosicoli
Activity: IC50 = 5.7
Assay: Inhibition of Brachyspira pilosicoli beta-lactamase OXA-63 expressed in Escherichia coli BL21 (DE3) assessed as reduction in nitrocefin hydrolysis by spectrophotometry relative to oxacillin
Drug: clavulanic acid
Target: Beta-lactamase (Enzyme)
Gene: blaCTX-M-53
UniProt: Q2XPY6 (Q2XPY6_SALET)
Organism: Salmonella enterica subsp. enterica serovar Westhampton
Activity: IC50 = 8
Assay: Inhibition of Salmonella enterica serotype Westhampton beta-lactamase CTX-M-53
Drug: clavulanic acid
Target: Beta-lactamase SHV-5 (Enzyme)
Gene: bla
UniProt: P0A3M1 (BLA5_KLEPN)
Organism: Klebsiella pneumoniae
Activity: Ki = 4.6
Assay: Inhibition of Klebsiella pneumoniae beta-lactamase SHV-105
Drug: clavulanic acid
Target: Beta-lactamase (Enzyme)
UniProt: D2SSQ3 (D2SSQ3_PSEAI)
Organism: Pseudomonas aeruginosa
Activity: IC50 = 7
Assay: Inhibition of Pseudomonas aeruginosa 531 beta-lactamase BEL-2
Drug: clavulanic acid
Target: Beta-lactamase (Enzyme)
Gene: bla(BEL1)
UniProt: Q3SAW3 (Q3SAW3_PSEAI)
Organism: Pseudomonas aeruginosa
Activity: IC50 = 7
Assay: Inhibition of Pseudomonas aeruginosa 51170 beta-lactamase BEL-1
Drug: clavulanic acid
Target: Beta-lactamase (Enzyme)
UniProt: Q670S6 (Q670S6_PSELU)
Organism: Pseudomonas luteola
Activity: IC50 = 7.44
Assay: Inhibition of Pseudomonas luteola LAM Beta-lactamase LUT-1
Drug: clebopride
Target: 5-hydroxytryptamine receptor 4 (GPCR)
Gene: HTR4
UniProt: O70528 (5HT4R_CAVPO)
Organism: Cavia porcellus
Activity: Ki = 6.98
Assay: Inhibition of [3H]GR-113808 binding to guinea pig striatum 5-hydroxytryptamine 4 receptor
Drug: clebopride
Target: D(2) dopamine receptor (GPCR)
Gene: DRD2
UniProt: P14416 (DRD2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.92
Assay: Displacement of [3H]-spiperone [0.5 nM (Kd=0.2-0.45 nM)] from human recombinant dopamine receptor D2S expressed in CHO cells at 0.5 nM concentration
Drug: clebopride
Target: Potassium voltage-gated channel subfamily H member 2 (Ion channel)
Gene: KCNH2
UniProt: Q12809 (KCNH2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.22
Assay: Inhibition of human ERG
Drug: clebopride
Target: D(3) dopamine receptor (GPCR)
Gene: DRD3
UniProt: P35462 (DRD3_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.98
Assay: In vitro binding affinity on D3 receptor is inhibition of binding of [125I]- NCQ 298 to Sf9 cells infected with recombinant baculovirus
Drug: clebopride
Target: D(4) dopamine receptor (GPCR)
Gene: DRD4
UniProt: P21917 (DRD4_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.49
Assay: Ability to displace [3H]spiperone [0.5 nM (Kd=0.1-0.45 nM)] from human recombinant dopamine receptor D4 expressed in CHO cells
Drug: clebopride
Target: Acetylcholinesterase (Enzyme)
Gene: ACHE
UniProt: P22303 (ACES_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.05
Assay: Inhibition of AChE
Drug: clebopride
Target: D(2) dopamine receptor (GPCR)
Gene: Drd2
UniProt: P61169 (DRD2_RAT)
Organism: Rattus norvegicus
Activity: Ki = 8.95
Assay: Inhibition of [125I]- NCQ 298 binding to D2 receptor of rat striatal tissue
Drug: clebopride
Target: D(1A) dopamine receptor (GPCR)
Gene: DRD1
UniProt: Q95136 (DRD1_BOVIN)
Organism: Bos taurus
Activity: Ki = 5.22
Assay: Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes
Drug: clebopride
Target: 5-hydroxytryptamine receptor 4 (GPCR)
Gene: Htr4
UniProt: Q62758 (5HT4R_RAT)
Organism: Rattus norvegicus
Activity: Ki = 6.98
Assay: Binding affinity against 5-hydroxytryptamine 4 receptor using [3H]GR-113808 as radioligand in rat striatum
Drug: clebopride
Target: Adrenergic receptor alpha-2 (GPCR)
Gene: Adra2b|Adra2c|Adra2a
UniProt: P19328|P22086|P22909 (ADA2B_RAT|ADA2C_RAT|ADA2A_RAT)
Organism: Rattus norvegicus
Activity: Ki = 6.22
Assay: In vitro binding affinity on alpha-2 receptor is inhibition of binding of [3H]- rauwolscine to rat cortex
Drug: clebopride
Target: Serotonin 2 (5-HT2) receptor (GPCR)
Gene: Htr2c|Htr2a|Htr2b
UniProt: P08909|P14842|P30994 (5HT2C_RAT|5HT2A_RAT|5HT2B_RAT)
Organism: Rattus norvegicus
Activity: Ki = 7.05
Assay: In vitro binding affinity on 5-hydroxytryptamine 2 receptor is inhibition of binding of [125I]- I-LSD to P11 cells
Drug: clemastine
Target: D(1A) dopamine receptor (GPCR)
Gene: DRD1
UniProt: P21728 (DRD1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.115
Assay: DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)
Drug: clemastine
Target: D(2) dopamine receptor (GPCR)
Gene: DRD2
UniProt: P14416 (DRD2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.347
Assay: DRUGMATRIX: Dopamine D2L radioligand binding (ligand: [3H] Spiperone)
Drug: clemastine
Target: Alpha-2A adrenergic receptor (GPCR)
Gene: ADRA2A
UniProt: P08913 (ADA2A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.161
Assay: DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)
Drug: clemastine
Target: Sigma non-opioid intracellular receptor 1 (Membrane receptor)
Gene: SIGMAR1
UniProt: Q99720 (SGMR1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.854
Assay: DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol)
Drug: clemastine
Target: Potassium voltage-gated channel subfamily H member 2 (Ion channel)
Gene: KCNH2
UniProt: Q12809 (KCNH2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.921
Drug: clemastine
Target: Sodium-dependent noradrenaline transporter (Transporter)
Gene: SLC6A2
UniProt: P23975 (SC6A2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.514
Assay: DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55)
Drug: clemastine
Target: 5-hydroxytryptamine receptor 2A (GPCR)
Gene: HTR2A
UniProt: P28223 (5HT2A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.036
Assay: DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin)
Drug: clemastine
Target: 5-hydroxytryptamine receptor 2B (GPCR)
Gene: HTR2B
UniProt: P41595 (5HT2B_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.638
Assay: DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
Drug: clemastine
Target: 5-hydroxytryptamine receptor 2C (GPCR)
Gene: HTR2C
UniProt: P28335 (5HT2C_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.284
Assay: DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine)
Drug: clemastine
Target: 5-hydroxytryptamine receptor 6 (GPCR)
Gene: HTR6
UniProt: P50406 (5HT6R_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.444
Assay: DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT6 radioligand binding (ligand: [3H] Lysergic acid diethylamide)
Drug: clemastine
Target: Alpha-2B adrenergic receptor (GPCR)
Gene: ADRA2B
UniProt: P18089 (ADA2B_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.848
Assay: DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug: clemastine
Target: D(3) dopamine receptor (GPCR)
Gene: DRD3
UniProt: P35462 (DRD3_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.604
Assay: DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone)
Drug: clemastine
Target: Histamine H1 receptor (GPCR)
Gene: HRH1
UniProt: P35367 (HRH1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.585
Action type: ANTAGONIST
Drug: clemastine
Target: Histamine H2 receptor (GPCR)
Gene: HRH2
UniProt: P25021 (HRH2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.439
Assay: DRUGMATRIX: Histamine H2 radioligand binding (ligand: [125I] Aminopotentidine)
Drug: clemastine
Target: Muscarinic acetylcholine receptor M1 (GPCR)
Gene: CHRM1
UniProt: P11229 (ACM1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.796
Drug: clemastine
Target: Muscarinic acetylcholine receptor M2 (GPCR)
Gene: CHRM2
UniProt: P08172 (ACM2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.703
Drug: clemastine
Target: Muscarinic acetylcholine receptor M3 (GPCR)
Gene: CHRM3
UniProt: P20309 (ACM3_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.084
Assay: DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)
Drug: clemastine
Target: Muscarinic acetylcholine receptor M4 (GPCR)
Gene: CHRM4
UniProt: P08173 (ACM4_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.558
Assay: DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine)
Drug: clemastine
Target: Muscarinic acetylcholine receptor M5 (GPCR)
Gene: CHRM5
UniProt: P08912 (ACM5_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.22
Assay: DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
Drug: clemastine
Target: Alpha-2C adrenergic receptor (GPCR)
Gene: ADRA2C
UniProt: P18825 (ADA2C_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.854
Assay: DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
Drug: clemastine
Target: Sodium-dependent dopamine transporter (Transporter)
Gene: SLC6A3
UniProt: Q01959 (SC6A3_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.269
Assay: DRUGMATRIX: Dopamine Transporter radioligand binding (ligand: [125I] RTI-55)
Drug: clemastine
Target: Cytochrome P450 2D6 (Enzyme)
Gene: CYP2D6
UniProt: P10635 (CP2D6_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.699
Drug: clemastine
Target: Alpha-1D adrenergic receptor (GPCR)
Gene: ADRA1D
UniProt: P25100 (ADA1D_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.824
Assay: DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug: clemastine
Target: Cytochrome P450 2C19 (Enzyme)
Gene: CYP2C19
UniProt: P33261 (CP2CJ_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.222
Assay: DRUGMATRIX: CYP450, 2C19 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)
Drug: clemastine
Target: Solute carrier family 22 member 1 (Transporter)
Gene: SLC22A1
UniProt: O15245 (S22A1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.31
Assay: Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells by confocal microscopy
Drug: clemastine
Target: Alpha-1B adrenergic receptor (GPCR)
Gene: Adra1b
UniProt: P15823 (ADA1B_RAT)
Organism: Rattus norvegicus
Activity: Ki = 7.387
Assay: DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
Drug: clemastine
Target: 5-hydroxytryptamine receptor 1B (GPCR)
Gene: Htr1b
UniProt: P28564 (5HT1B_RAT)
Organism: Rattus norvegicus
Activity: Ki = 6.658
Assay: DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)
Drug: clemastine
Target: Membrane-associated progesterone receptor component 1 (Membrane receptor)
Gene: Pgrmc1
UniProt: P70580 (PGRC1_RAT)
Organism: Rattus norvegicus
Activity: Ki = 6.349
Assay: DRUGMATRIX: Sigma2 radioligand binding (ligand: [3H] Ifenprodil)
Drug: clemastine
Target: Alpha-1A adrenergic receptor (GPCR)
Gene: Adra1a
UniProt: P43140 (ADA1A_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 7.28
Drug: clemastine
Target: Transmembrane protein 97 (Enzyme)
Gene: TMEM97
UniProt: Q5BJF2 (TMM97_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.6
Assay: Displacement of [3H]-DTG from the Sigma2 receptor
Drug: clemizole
Target: Histamine H4 receptor (GPCR)
Gene: HRH4
UniProt: Q9H3N8 (HRH4_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.396
Drug: clemizole
Target: Heme oxygenase 2 (Enzyme)
Gene: Hmox2
UniProt: P23711 (HMOX2_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 5.47
Assay: Inhibition of HO-2 in Sprague-Dawley rat brain microsomal fractions assessed as carbon monoxide formation from methemalbumin after 10 mins by gas chromatography analysis
Drug: clemizole
Target: Short transient receptor potential channel 4 (Ion channel)
Gene: TRPC4
UniProt: Q9UBN4 (TRPC4_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.19
Action type: BLOCKER
Drug: clemizole
Target: Short transient receptor potential channel 5 (Ion channel)
Gene: TRPC5
UniProt: Q9UL62 (TRPC5_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.96
Action type: BLOCKER
Drug: clemizole
Target: Short transient receptor potential channel 3 (Ion channel)
Gene: TRPC3
UniProt: Q13507 (TRPC3_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.04
Action type: BLOCKER
Drug: clemizole
Target: Short transient receptor potential channel 6 (Ion channel)
Gene: TRPC6
UniProt: Q9Y210 (TRPC6_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.89
Action type: BLOCKER
Drug: clenbuterol
Target: Beta-1 adrenergic receptor (GPCR)
Gene: ADRB1
UniProt: P08588 (ADRB1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.161
Assay: DRUGMATRIX: Adrenergic beta1 radioligand binding (ligand: [125I] Cyanopindolol)
Drug: clenbuterol
Target: Beta-2 adrenergic receptor (GPCR)
Gene: ADRB2
UniProt: P07550 (ADRB2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.8
Assay: Binding affinity to beta-2 adrenergic receptor (unknown origin) at 1 to 10000 nM
Drug: clenbuterol
Target: 5-hydroxytryptamine receptor 1A (GPCR)
Gene: HTR1A
UniProt: P08908 (5HT1A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.82
Assay: DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1A radioligand binding (ligand: [3H] 8-OH-DPAT)
Drug: clenbuterol
Target: 5-hydroxytryptamine receptor 1A (GPCR)
Gene: Htr1a
UniProt: P19327 (5HT1A_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 5.58
Drug: clenbuterol
Target: Beta-2 adrenergic receptor (GPCR)
Gene: ADRB2
UniProt: Q28044 (ADRB2_BOVIN)
Organism: Bos taurus
Activity: Kd = 7.44
Assay: Affinity for cow beta-2 adrenergic receptor by measuring displacement (-)-[3H]dihydroalprenolol (DHA)
Drug: clevidipine
Target: Voltage-dependent L-type calcium channel subunit alpha-1C (Ion channel)
Gene: CACNA1C
UniProt: Q13936 (CAC1C_HUMAN)
Organism: Homo sapiens
Action type: BLOCKER
Drug: clevidipine
Target: Voltage-dependent L-type calcium channel subunit alpha-1D (Ion channel)
Gene: CACNA1D
UniProt: Q01668 (CAC1D_HUMAN)
Organism: Homo sapiens
Action type: BLOCKER
Drug: clidinium
Target: Muscarinic acetylcholine receptor M1 (GPCR)
Gene: CHRM1
UniProt: P11229 (ACM1_HUMAN)
Organism: Homo sapiens
Action type: ANTAGONIST
Assay: Mechanism of Action; CHEMBL216; SINGLE PROTEIN
Drug: clidinium
Target: Muscarinic acetylcholine receptor M3 (GPCR)
Gene: CHRM3
UniProt: P20309 (ACM3_HUMAN)
Organism: Homo sapiens
Activity: Ki = 9.6
Action type: ANTAGONIST
Drug: clindamycin
Target: 50S ribosomal protein L10 (Ribosomal protein)
Gene: rpl10
UniProt: P15825 (RL10_HALMA)
Organism: Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809)
Drug: clioquinol
Target: Catechol O-methyltransferase (Enzyme)
Gene: Comt
UniProt: P22734 (COMT_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 5.32
Assay: Inhibition of Sprague-Dawley rat liver COMT after 10 mins using 0.05 uCi [14CH3]-SAM as substrate
Drug: clioquinol
Target: Botulinum neurotoxin type A (Enzyme)
Gene: botA
UniProt: P10845 (BXA1_CLOBO)
Organism: Clostridium botulinum
Activity: IC50 = 4.69
Assay: Inhibition of Clostridium botulinum BoNT/A LC expressed in Escherichia coli assessed as cleavage of SNAPtide preincubated for 5 mins followed by SNAPtide addition measured for 105 mins by fluorescence assay
Drug: clioquinol
Target: Carbonic anhydrase 15 (Enzyme)
Gene: Ca15
UniProt: Q99N23 (CAH15_MOUSE)
Organism: Mus musculus
Activity: Ki = 5.63
Assay: Inhibition of mouse recombinant carbonic anhydrase 15 by stopped-flow CO2 hydrase assay
Drug: clioquinol
Target: Amyloid beta A4 protein (Unclassified)
Gene: APP
UniProt: P05067 (A4_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4
Assay: Inhibition of amyloid beta (1 to 42) aggregation (unknown origin) at 4:1 compound to protein concentration after 48 hrs by thioflavin T fluorescence assay
Drug: clobazam
Target: GABA-A receptor alpha-1/beta-2/gamma-2 (Ion channel)
Gene: GABRA1|GABRG2|GABRB2
UniProt: P14867|P18507|P47870 (GBRA1_HUMAN|GBRG2_HUMAN|GBRB2_HUMAN)
Organism: Homo sapiens
Action type: POSITIVE ALLOSTERIC MODULATOR
Drug: clodronic acid
Target: ADP/ATP translocase 2 (Enzyme)
Gene: SLC25A5
UniProt: P05141 (ADT2_HUMAN)
Organism: Homo sapiens
Drug: clodronic acid
Target: ADP/ATP translocase 1 (Transporter)
Gene: SLC25A4
UniProt: P12235 (ADT1_HUMAN)
Organism: Homo sapiens
Drug: clodronic acid
Target: ADP/ATP translocase 3 (Enzyme)
Gene: SLC25A6
UniProt: P12236 (ADT3_HUMAN)
Organism: Homo sapiens
Drug: clodronic acid
Target: Tyrosine-protein phosphatase non-receptor type 1 (Enzyme)
Gene: PTPN1
UniProt: P18031 (PTN1_HUMAN)
Organism: Homo sapiens
Drug: clodronic acid
Target: Solute carrier family 17 member 9 (Transporter)
Gene: SLC17A9
UniProt: Q9BYT1 (S17A9_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7.81
Action type: INHIBITOR
Assay: Using a quantitative transport assay system involving proteoliposomes containing only expressed and purified protein.