AIM-Harvard/TrialPanorama-filtered huggingface dataset:
Drug: topiramate
Target: Delta carbonic anhydrase (Unclassified)
Gene: ca1
UniProt: Q5U9J1 (Q5U9J1_THAWE)
Organism: Thalassiosira weissflogii
Activity: Ki = 6.41
Assay: Inhibition of Thalassiosira weissflogii delta carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration assay
Drug: topiramate
Target: Carbonic anhydrase 2 (Enzyme)
Gene: mtcA2
UniProt: P9WPJ9 (MTCA2_MYCTU)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Activity: Ki = 6.32
Assay: Inhibition of full length Mycobacterium tuberculosis H37Rv recombinant carbonic anhydrase 2 encoded by RV3588c by stopped flow CO2 hydration assay
Drug: topiramate
Target: GABA-A receptor alpha-1/beta-2/gamma-2 (Ion channel)
Gene: GABRA1|GABRG2|GABRB2
UniProt: P14867|P18507|P47870 (GBRA1_HUMAN|GBRG2_HUMAN|GBRB2_HUMAN)
Organism: Homo sapiens
Action type: POSITIVE MODULATOR
Drug: topiramate
Target: Carbonic anhydrase V (Enzyme)
Gene: CA5A|CA5B
UniProt: P35218|Q9Y2D0 (CAH5A_HUMAN|CAH5B_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.6
Assay: Mean inhibitory constant towards human carbonic anhydrase V determined by spectrophotometric dansylamide binding assay
Drug: topiramate
Target: Glutamate receptor ionotropic kainate (Ion channel)
Gene: GRIK1|GRIK2|GRIK3|GRIK4|GRIK5
UniProt: P39086|Q13002|Q13003|Q16099|Q16478 (GRIK1_HUMAN|GRIK2_HUMAN|GRIK3_HUMAN|GRIK4_HUMAN|GRIK5_HUMAN)
Organism: Homo sapiens
Action type: ANTAGONIST
Assay: Mechanism of Action; CHEMBL2109241; PROTEIN COMPLEX GROUP
Drug: topiramate
Target: Glutamate receptor ionotropic AMPA (Ion channel)
Gene: GRIA1|GRIA2|GRIA3|GRIA4
UniProt: P42261|P42262|P42263|P48058 (GRIA1_HUMAN|GRIA2_HUMAN|GRIA3_HUMAN|GRIA4_HUMAN)
Organism: Homo sapiens
Action type: ANTAGONIST
Assay: Mechanism of Action; CHEMBL2096670; PROTEIN COMPLEX GROUP
Drug: topiramate
Target: Carbonic anhydrase, alpha family (Unclassified)
UniProt: Q31FD6 (Q31FD6_HYDCU)
Organism: Hydrogenovibrio crunogenus (strain XCL-2)
Activity: Ki = 6.11
Assay: Inhibition of recombinant Thiomicrospira crunogena XCL-2 carbonic anhydrase by stopped flow CO2 hydrase assay
Drug: topiramate
Target: Carbonate dehydratase (Enzyme)
UniProt: B2V8E3 (B2V8E3_SULSY)
Organism: Sulfurihydrogenibium sp. (strain YO3AOP1)
Activity: Ki = 8.18
Assay: Inhibition of recombinant Sulfurihydrogenibium yellowstonense YO3AOP1 carbonic anhydrase by stopped flow CO2 hydrase assay
Drug: topotecan
Target: Cytochrome P450 3A4 (Enzyme)
Gene: CYP3A4
UniProt: P08684 (CP3A4_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.818
Assay: DRUGMATRIX: CYP450, 3A4 enzyme inhibition (substrate: 7-Benzyloxy-4-(trifluoromethyl)-coumarin)
Drug: topotecan
Target: Multidrug resistance protein 1 (Transporter)
Gene: ABCB1
UniProt: P08183 (MDR1_HUMAN)
Organism: Homo sapiens
Drug: topotecan
Target: Canalicular multispecific organic anion transporter 1 (Transporter)
Gene: ABCC2
UniProt: Q92887 (MRP2_HUMAN)
Organism: Homo sapiens
Drug: topotecan
Target: Nuclear receptor subfamily 1 group I member 2 (Nuclear hormone receptor)
Gene: NR1I2
UniProt: O75469 (NR1I2_HUMAN)
Organism: Homo sapiens
Drug: topotecan
Target: ATP-binding cassette sub-family G member 2 (Transporter)
Gene: ABCG2
UniProt: Q9UNQ0 (ABCG2_HUMAN)
Organism: Homo sapiens
Drug: topotecan
Target: Multidrug resistance-associated protein 4 (Transporter)
Gene: ABCC4
UniProt: O15439 (MRP4_HUMAN)
Organism: Homo sapiens
Drug: topotecan
Target: DNA topoisomerase I, mitochondrial (Enzyme)
Gene: TOP1MT
UniProt: Q969P6 (TOP1M_HUMAN)
Organism: Homo sapiens
Action type: INHIBITOR
Drug: topotecan
Target: DNA topoisomerase 1 (Enzyme)
Gene: TOP1
UniProt: P11387 (TOP1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.58
Assay: Binding affinity to topoisomerase 1
Drug: topotecan
Target: Hypoxia-inducible factor 1-alpha (Transcription factor)
Gene: HIF1A
UniProt: Q16665 (HIF1A_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7.22
Assay: Inhibition of HIF1alpha in human U251 cells under hypoxic condition by luciferase reporter gene assay
Drug: topotecan
Target: Solute carrier family 22 member 2 (Transporter)
Gene: SLC22A2
UniProt: O15244 (S22A2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.21
Assay: Inhibition of human OCT2-mediated ASP+ uptake expressed in HEK293 cells after 3 mins by fluorescence assay
Drug: topotecan
Target: Multidrug and toxin extrusion protein 1 (Transporter)
Gene: SLC47A1
UniProt: Q96FL8 (S47A1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.89
Assay: Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay
Drug: topotecan
Target: Multidrug and toxin extrusion protein 2 (Transporter)
Gene: SLC47A2
UniProt: Q86VL8 (S47A2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.07
Assay: Inhibition of human MATE2K-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay
Drug: topotecan
Target: DNA topoisomerase I (Enzyme)
Gene: Top1
UniProt: Q04750 (TOP1_MOUSE)
Organism: Mus musculus
Activity: IC50 = 4.7
Assay: Average concentration to cause 50% inhibition of topo 1 using the cleavable complex assay
Drug: topotecan
Target: ORF 73 (Unclassified)
UniProt: O40947 (O40947_HHV8)
Organism: Human herpesvirus 8
Activity: AC50 = 5.67
Assay: Active
Drug: topotecan
Target: UDP-galactopyranose mutase (Enzyme)
Gene: glf
UniProt: P9WIQ1 (GLF_MYCTU)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Activity: AC50 = 5.16
Assay: active
Drug: torsemide
Target: Solute carrier family 12 member 1 (Transporter)
Gene: SLC12A1
UniProt: Q13621 (S12A1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.4
Action type: INHIBITOR
Drug: toremifene
Target: 5-hydroxytryptamine receptor 6 (GPCR)
Gene: HTR6
UniProt: P50406 (5HT6R_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.38
Assay: Displacement of [3H]LSD from human 5HT6 receptor expressed in HEK293 cells after 1.5 hrs by liquid scintillation counting
Drug: toremifene
Target: Estrogen receptor (Nuclear hormone receptor)
Gene: ESR1
UniProt: P03372 (ESR1_HUMAN)
Organism: Homo sapiens
Action type: MODULATOR
Drug: toremifene
Target: Estrogen-related receptor gamma (Nuclear hormone receptor)
Gene: ESRRG
UniProt: P62508 (ERR3_HUMAN)
Organism: Homo sapiens
Drug: toremifene
Target: Envelope glycoprotein (Unclassified)
Gene: GP
UniProt: Q05320 (VGP_EBOZM)
Organism: Zaire ebolavirus
Activity: Kd = 4.8
Assay: Binding affinity to Ebola virus Zaire Mayinga-76 recombinant GP protein by SYPRO orange dye-based fluorescence assay
Drug: tramadol
Target: Mu-type opioid receptor (GPCR)
Gene: OPRM1
UniProt: P35372 (OPRM_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.8
Action type: AGONIST
Assay: Displacement of [3H]DAMGO form human mu opioid receptor expressed in CHO cells
Drug: tramadol
Target: Sodium-dependent serotonin transporter (Transporter)
Gene: SLC6A4
UniProt: P31645 (SC6A4_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.83
Assay: Inhibition of SERT mediated 5-hydroxytryptamine uptake
Drug: tramadol
Target: Sodium-dependent noradrenaline transporter (Transporter)
Gene: SLC6A2
UniProt: P23975 (SC6A2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.1
Assay: Inhibition of reuptake of Norepinephrine
Drug: tramadol
Target: Kappa-type opioid receptor (GPCR)
Gene: OPRK1
UniProt: P41145 (OPRK_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.85
Assay: Displacement of [3H]U69593 form human kappa opioid receptor expressed in CHO cells
Drug: tramadol
Target: Delta-type opioid receptor (GPCR)
Gene: OPRD1
UniProt: P41143 (OPRD_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.03
Assay: Displacement of [3H]Naltrindole form human delta opioid receptor expressed in CHO cells
Drug: tramadol
Target: Solute carrier family 22 member 1 (Transporter)
Gene: SLC22A1
UniProt: O15245 (S22A1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.28
Drug: tramadol
Target: Mu-type opioid receptor (GPCR)
Gene: Oprm1
UniProt: P33535 (OPRM_RAT)
Organism: Rattus norvegicus
Activity: Ki = 5.62
Assay: Displacement of [3H]-dihydromorphine from mu opioid receptor in rat cerebral cortex by liquid scintillation counting
Drug: trandolapril
Target: Angiotensin-converting enzyme (Enzyme)
Gene: ACE
UniProt: P12821 (ACE_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 8.12
Action type: INHIBITOR
Drug: tranexamic acid
Target: Plasminogen (Enzyme)
Gene: PLG
UniProt: P00747 (PLMN_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.96
Action type: INHIBITOR
Assay: Binding affinity to human plasma full length Glu-plasminogen K1 domain by surface plasmon resonance analysis
Drug: tranilast
Target: Hematopoietic prostaglandin D synthase (Enzyme)
Gene: HPGDS
UniProt: O60760 (HPGDS_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.94
Assay: Inhibition of glutathione-S-transferase activity of prostaglandin D2 synthase
Drug: tranylcypromine
Target: Sodium-dependent noradrenaline transporter (Transporter)
Gene: SLC6A2
UniProt: P23975 (SC6A2_HUMAN)
Organism: Homo sapiens
Activity: Ki  5.229
Drug: tranylcypromine
Target: 5-hydroxytryptamine receptor 1A (GPCR)
Gene: HTR1A
UniProt: P08908 (5HT1A_HUMAN)
Organism: Homo sapiens
Activity: Ki  5.225
Drug: tranylcypromine
Target: Sodium-dependent dopamine transporter (Transporter)
Gene: SLC6A3
UniProt: Q01959 (SC6A3_HUMAN)
Organism: Homo sapiens
Activity: Ki  5.292
Drug: tranylcypromine
Target: Cytochrome P450 2A6 (Enzyme)
Gene: CYP2A6
UniProt: P11509 (CP2A6_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.187
Drug: tranylcypromine
Target: Amine oxidase [flavin-containing] B (Enzyme)
Gene: MAOB
UniProt: P27338 (AOFB_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7.48
Action type: INHIBITOR
Assay: Compound was evaluated for inhibition of Microbial tyramine oxidase; irreversible
Drug: tranylcypromine
Target: Amine oxidase [flavin-containing] A (Enzyme)
Gene: MAOA
UniProt: P21397 (AOFA_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.62
Assay: Inhibition of human recombinant MAO-A assessed as kynuramine oxidation to 4-hydroxyquinoline after 40 mins by LC-MS/MS analysis
Drug: tranylcypromine
Target: Cytochrome P450 2C19 (Enzyme)
Gene: CYP2C19
UniProt: P33261 (CP2CJ_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.3
Assay: Fluorescent High Throughput P450 Assay: The interaction of SC12 with cytochrome P450 enzymes was tested using Fluorescent High Throughput P450 assays (Gentest) The IC50s of the compounds was calculated on isoenzymes (CYP1A2, CYP2C9, CYP2C19, CYP2C8, CYP2B6, CYP2D6, CYP2E1, CYP3A4 and CYP3A5). Inhibition of the P450 isoforms was measured in specific assays using specific substrates that become fluorescent upon CYP metabolism. Compounds, dissolved in ACN (acetonitrile) (CYP2E1, CYP2C8, CYP2B6, CYP3A5) or DMSO (all remaining isoforms), were tested in duplicate (n=2) in concentration-response curves (eight concentrations) in a 96-well plate containing incubation/NADPH regenerating buffer. Specific isoenzymes and substrates were added and incubated at 37° C. Reactions were terminated at different times, depending on the assays, and plates read on a Fluoroskan Ascent at the appropriate emission/excitation wavelengths. Concentration-response curves performed in duplicate for known i
Drug: tranylcypromine
Target: Cytochrome P450 2B6 (Enzyme)
Gene: CYP2B6
UniProt: P20813 (CP2B6_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.16
Assay: Fluorescent High Throughput P450 Assay: The interaction of SC12 with cytochrome P450 enzymes was tested using Fluorescent High Throughput P450 assays (Gentest) The IC50s of the compounds was calculated on isoenzymes (CYP1A2, CYP2C9, CYP2C19, CYP2C8, CYP2B6, CYP2D6, CYP2E1, CYP3A4 and CYP3A5). Inhibition of the P450 isoforms was measured in specific assays using specific substrates that become fluorescent upon CYP metabolism. Compounds, dissolved in ACN (acetonitrile) (CYP2E1, CYP2C8, CYP2B6, CYP3A5) or DMSO (all remaining isoforms), were tested in duplicate (n=2) in concentration-response curves (eight concentrations) in a 96-well plate containing incubation/NADPH regenerating buffer. Specific isoenzymes and substrates were added and incubated at 37° C. Reactions were terminated at different times, depending on the assays, and plates read on a Fluoroskan Ascent at the appropriate emission/excitation wavelengths. Concentration-response curves performed in duplicate for known i
Drug: tranylcypromine
Target: Cationic trypsin (Enzyme)
UniProt: P00760 (TRY1_BOVIN)
Organism: Bos taurus
Activity: Ki = 4.88
Assay: Binding affinity against bovine trypsin
Drug: tranylcypromine
Target: D(2) dopamine receptor (GPCR)
Gene: Drd2
UniProt: P61169 (DRD2_RAT)
Organism: Rattus norvegicus
Activity: Ki = 4.23
Assay: Displacement of [3H]Spiperone from dopamine D2-like receptor in Sprague-Dawley rat caudate putamen after 90 mins
Drug: tranylcypromine
Target: Amine oxidase [flavin-containing] B (Enzyme)
Gene: Maob
UniProt: P19643 (AOFB_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 7.11
Assay: Inhibition of rat MAO-B using benzylamine as substrate
Drug: tranylcypromine
Target: Amine oxidase [flavin-containing] A (Enzyme)
Gene: Maoa
UniProt: P21396 (AOFA_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 6.54
Assay: Inhibition of rat MAO-A using serotonin as substrate incubated for 1 hr
Drug: tranylcypromine
Target: D(3) dopamine receptor (GPCR)
Gene: Drd3
UniProt: P19020 (DRD3_RAT)
Organism: Rattus norvegicus
Activity: Ki = 4.89
Drug: tranylcypromine
Target: Lysine-specific histone demethylase 1A (Enzyme)
Gene: KDM1A
UniProt: O60341 (KDM1A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 4.6
Assay: Inhibition of human recombinant His-tagged full length LSD1 expressed in Escherichia coli BL21 (DE3) assessed as inactivation constant preincubated for 20 mins with substrate measured after 30 mins by AmplexRed based fluorescence quenching assay
Drug: tranylcypromine
Target: Lysine-specific histone demethylase 1B (Enzyme)
Gene: KDM1B
UniProt: Q8NB78 (KDM1B_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.46
Assay: Inhibition of recombinant LSD2 (22 to 822 aa) (unknown origin) expressed in Escherichia coli BL21(DE) by fluorescence assay
Drug: tranylcypromine
Target: 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase (Enzyme)
Gene: CYP8B1
UniProt: Q9UNU6 (CP8B1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.11
Assay: Inhibition of CYP8B1 in human liver microsomes using D7-7alpha-hydroxy-4-cholesten-3-one as substrate preincubated for 20 mins followed by substrate addition in presence of NADPH by UPLC-ESI-MS/MS analysis
Drug: travoprost
Target: Prostaglandin E2 receptor EP3 subtype (GPCR)
Gene: PTGER3
UniProt: P43115 (PE2R3_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.456
Assay: inhibition of [3H]AL-5848 binding to prostaglandin EP3 receptor
Drug: travoprost
Target: Prostaglandin F2-alpha receptor (GPCR)
Gene: PTGFR
UniProt: P43088 (PF2R_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.284
Action type: AGONIST
Assay: inhibition of [3H]AL-5848 binding to prostaglandin FP receptor
Drug: trazodone
Target: D(1A) dopamine receptor (GPCR)
Gene: DRD1
UniProt: P21728 (DRD1_HUMAN)
Organism: Homo sapiens
Activity: Ki  5.428
Drug: trazodone
Target: D(2) dopamine receptor (GPCR)
Gene: DRD2
UniProt: P14416 (DRD2_HUMAN)
Organism: Homo sapiens
Activity: Ki  5.456
Drug: trazodone
Target: Alpha-2A adrenergic receptor (GPCR)
Gene: ADRA2A
UniProt: P08913 (ADA2A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.58
Drug: trazodone
Target: Sigma non-opioid intracellular receptor 1 (Membrane receptor)
Gene: SIGMAR1
UniProt: Q99720 (SGMR1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.033
Assay: DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol)
Drug: trazodone
Target: Potassium voltage-gated channel subfamily H member 2 (Ion channel)
Gene: KCNH2
UniProt: Q12809 (KCNH2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.54
Drug: trazodone
Target: Sodium-dependent serotonin transporter (Transporter)
Gene: SLC6A4
UniProt: P31645 (SC6A4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.8
Action type: INHIBITOR
Drug: trazodone
Target: Sodium-dependent noradrenaline transporter (Transporter)
Gene: SLC6A2
UniProt: P23975 (SC6A2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.07
Drug: trazodone
Target: 5-hydroxytryptamine receptor 1A (GPCR)
Gene: HTR1A
UniProt: P08908 (5HT1A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.018
Drug: trazodone
Target: 5-hydroxytryptamine receptor 2A (GPCR)
Gene: HTR2A
UniProt: P28223 (5HT2A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.35
Action type: ANTAGONIST
Drug: trazodone
Target: 5-hydroxytryptamine receptor 2B (GPCR)
Gene: HTR2B
UniProt: P41595 (5HT2B_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.08
Drug: trazodone
Target: 5-hydroxytryptamine receptor 2C (GPCR)
Gene: HTR2C
UniProt: P28335 (5HT2C_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.65
Action type: ANTAGONIST
Drug: trazodone
Target: 5-hydroxytryptamine receptor 7 (GPCR)
Gene: HTR7
UniProt: P34969 (5HT7R_HUMAN)
Organism: Homo sapiens
Activity: Ki  5.749
Drug: trazodone
Target: Alpha-1A adrenergic receptor (GPCR)
Gene: ADRA1A
UniProt: P35348 (ADA1A_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 9.551
Drug: trazodone
Target: Alpha-2B adrenergic receptor (GPCR)
Gene: ADRA2B
UniProt: P18089 (ADA2B_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.75
Assay: DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug: trazodone
Target: D(3) dopamine receptor (GPCR)
Gene: DRD3
UniProt: P35462 (DRD3_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.896
Assay: DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone)
Drug: trazodone
Target: Histamine H1 receptor (GPCR)
Gene: HRH1
UniProt: P35367 (HRH1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.21
Drug: trazodone
Target: Histamine H2 receptor (GPCR)
Gene: HRH2
UniProt: P25021 (HRH2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.483
Drug: trazodone
Target: 5-hydroxytryptamine receptor 1D (GPCR)
Gene: HTR1D
UniProt: P28221 (5HT1D_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.975
Drug: trazodone
Target: Alpha-2C adrenergic receptor (GPCR)
Gene: ADRA2C
UniProt: P18825 (ADA2C_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.81
Drug: trazodone
Target: Sodium-dependent dopamine transporter (Transporter)
Gene: SLC6A3
UniProt: Q01959 (SC6A3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.13
Drug: trazodone
Target: D(4) dopamine receptor (GPCR)
Gene: DRD4
UniProt: P21917 (DRD4_HUMAN)
Organism: Homo sapiens
Activity: Ki  6.153
Drug: trazodone
Target: Alpha-1D adrenergic receptor (GPCR)
Gene: ADRA1D
UniProt: P25100 (ADA1D_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.328
Assay: DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug: trazodone
Target: Alpha-1B adrenergic receptor (GPCR)
Gene: Adra1b
UniProt: P15823 (ADA1B_RAT)
Organism: Rattus norvegicus
Activity: Ki = 7.215
Assay: DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
Drug: trazodone
Target: 5-hydroxytryptamine receptor 1B (GPCR)
Gene: Htr1b
UniProt: P28564 (5HT1B_RAT)
Organism: Rattus norvegicus
Activity: Ki = 6.081
Assay: DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)
Drug: trazodone
Target: Membrane-associated progesterone receptor component 1 (Membrane receptor)
Gene: Pgrmc1
UniProt: P70580 (PGRC1_RAT)
Organism: Rattus norvegicus
Activity: Ki = 6.083
Assay: DRUGMATRIX: Sigma2 radioligand binding (ligand: [3H] Ifenprodil)
Drug: trazodone
Target: Alpha-1A adrenergic receptor (GPCR)
Gene: Adra1a
UniProt: P43140 (ADA1A_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 6.93
Drug: trazodone
Target: 5-hydroxytryptamine receptor 1A (GPCR)
Gene: Htr1a
UniProt: P19327 (5HT1A_RAT)
Organism: Rattus norvegicus
Activity: Ki = 6.65
Drug: trazodone
Target: 5-hydroxytryptamine receptor 2A (GPCR)
Gene: Htr2a
UniProt: P14842 (5HT2A_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 7.77
Assay: Compound was tested for the inhibition of [3H]ketanserin binding to 5-hydroxytryptamine 2A receptor
Drug: trazodone
Target: 5-hydroxytryptamine receptor 2C (GPCR)
Gene: Htr2c
UniProt: P08909 (5HT2C_RAT)
Organism: Rattus norvegicus
Activity: Ki = 6.7
Action type: ANTAGONIST
Drug: trazodone
Target: HLA class I histocompatibility antigen, A-3 alpha chain (Unclassified)
Gene: HLA-A
UniProt: P04439 (1A03_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.6
Assay: Binding affinity to human biotinylated HLA-A2 by surface plasmon resonance assay
Drug: treprostinil
Target: Prostaglandin E2 receptor EP1 subtype (GPCR)
Gene: PTGER1
UniProt: P34995 (PE2R1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.7
Action type: AGONIST
Drug: treprostinil
Target: Prostaglandin E2 receptor EP3 subtype (GPCR)
Gene: PTGER3
UniProt: P43115 (PE2R3_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.6
Action type: AGONIST
Drug: treprostinil
Target: Prostacyclin receptor (GPCR)
Gene: PTGIR
UniProt: P43119 (PI2R_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 8.72
Action type: AGONIST
Drug: treprostinil
Target: Prostaglandin E2 receptor EP2 subtype (GPCR)
Gene: PTGER2
UniProt: P43116 (PE2R2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.4
Action type: AGONIST
Drug: treprostinil
Target: Prostaglandin E2 receptor EP4 subtype (GPCR)
Gene: PTGER4
UniProt: P35408 (PE2R4_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 6.7
Action type: AGONIST
Drug: treprostinil
Target: Prostaglandin D2 receptor (GPCR)
Gene: PTGDR
UniProt: Q13258 (PD2R_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.4
Action type: AGONIST
Drug: tretinoin
Target: 5-hydroxytryptamine receptor 2B (GPCR)
Gene: HTR2B
UniProt: P41595 (5HT2B_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.642
Assay: DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
Drug: tretinoin
Target: Adenosine receptor A3 (GPCR)
Gene: ADORA3
UniProt: P0DMS8 (AA3R_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.525
Assay: DRUGMATRIX: Adenosine A3 radioligand binding (ligand: AB-MECA)
Drug: tretinoin
Target: Retinoic acid receptor alpha (Nuclear hormone receptor)
Gene: RARA
UniProt: P10276 (RARA_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 6.7
Action type: AGONIST
Drug: tretinoin
Target: 11-cis retinol dehydrogenase (Enzyme)
Gene: RDH5
UniProt: Q92781 (RDH1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7
Drug: tretinoin
Target: Nuclear receptor ROR-alpha (Nuclear hormone receptor)
Gene: RORA
UniProt: P35398 (RORA_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.7
Drug: tretinoin
Target: Retinoic acid receptor RXR-alpha (Nuclear hormone receptor)
Gene: RXRA
UniProt: P19793 (RXRA_HUMAN)
Organism: Homo sapiens
Activity: Ki = 9.4
Assay: Binding affinity for retinoic acid receptor RAR alpha
Drug: tretinoin
Target: Retinoic acid receptor RXR-beta (Nuclear hormone receptor)
Gene: RXRB
UniProt: P28702 (RXRB_HUMAN)
Organism: Homo sapiens
Activity: Ki = 9.3
Assay: Binding affinity for retinoic acid receptor RAR beta
Drug: tretinoin
Target: Retinoic acid receptor RXR-gamma (Nuclear hormone receptor)
Gene: RXRG
UniProt: P48443 (RXRG_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.85
Assay: Binding affinity for retinoic acid receptor RAR gamma
Drug: tretinoin
Target: Retinoic acid receptor beta (Nuclear hormone receptor)
Gene: RARB
UniProt: P10826 (RARB_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 6.7
Action type: AGONIST
Drug: tretinoin
Target: Retinoic acid receptor gamma (Nuclear hormone receptor)
Gene: RARG
UniProt: P13631 (RARG_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 6.7
Action type: AGONIST
Drug: tretinoin
Target: Peroxisome proliferator-activated receptor delta (Nuclear hormone receptor)
Gene: PPARD
UniProt: Q03181 (PPARD_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.8
Action type: AGONIST
Drug: tretinoin
Target: Nuclear receptor ROR-beta (Nuclear hormone receptor)
Gene: RORB
UniProt: Q92753 (RORB_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 9.82
Action type: ANTAGONIST
Drug: tretinoin
Target: Nuclear receptor ROR-gamma (Nuclear hormone receptor)
Gene: RORC
UniProt: P51449 (RORG_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.7
Drug: tretinoin
Target: Mitogen-activated protein kinase 1 (Kinase)
Gene: MAPK1
UniProt: P28482 (MK01_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.24
Assay: DRUGMATRIX: Protein Serine/Threonine Kinase, ERK2 enzyme inhibition (substrate: Myelin Basic Protein)
Drug: tretinoin
Target: Cellular retinoic acid-binding protein 1 (Cytosolic other)
Gene: CRABP1
UniProt: P40220 (RABP1_CHICK)
Organism: Gallus gallus
Activity: IC50 = 6.43
Assay: Tested for its ability to inhibit the binding of (all-E-)-RA to cytoplasmic retinoic acid-binding protein (CRABP) from chick skin