AIM-Harvard/TrialPanorama-filtered huggingface dataset:
Drug: bosutinib
Target: Platelet-derived growth factor receptor alpha (Kinase)
Gene: PDGFRA
UniProt: P16234 (PGFRA_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.29
Assay: Binding constant for PDGFRA kinase domain
Drug: bosutinib
Target: Receptor tyrosine-protein kinase erbB-2 (Kinase)
Gene: ERBB2
UniProt: P04626 (ERBB2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.6
Assay: Binding constant for ERBB2 kinase domain
Drug: bosutinib
Target: Ribosomal protein S6 kinase alpha-3 (Kinase)
Gene: RPS6KA3
UniProt: P51812 (KS6A3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.92
Assay: Binding constant for RSK2(Kin.Dom.1-N-terminal) kinase domain
Drug: bosutinib
Target: Phosphorylase b kinase gamma catalytic chain, liver/testis isoform (Kinase)
Gene: PHKG2
UniProt: P15735 (PHKG2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.89
Assay: Binding constant for PHKG2 kinase domain
Drug: bosutinib
Target: Myosin light chain kinase, smooth muscle (Kinase)
Gene: MYLK
UniProt: Q15746 (MYLK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.31
Assay: Binding constant for MYLK kinase domain
Drug: bosutinib
Target: Rho-associated protein kinase 1 (Kinase)
Gene: ROCK1
UniProt: Q13464 (ROCK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.06
Assay: Binding constant for ROCK1 kinase domain
Drug: bosutinib
Target: Focal adhesion kinase 1 (Kinase)
Gene: PTK2
UniProt: Q05397 (FAK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.24
Assay: Binding constant for FAK kinase domain
Drug: bosutinib
Target: Tyrosine-protein kinase HCK (Kinase)
Gene: HCK
UniProt: P08631 (HCK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.47
Action type: INHIBITOR
Assay: Binding constant for HCK kinase domain
Drug: bosutinib
Target: Serine/threonine-protein kinase PLK1 (Kinase)
Gene: PLK1
UniProt: P53350 (PLK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.74
Assay: Binding constant for PLK1 kinase domain
Drug: bosutinib
Target: Receptor tyrosine-protein kinase erbB-4 (Kinase)
Gene: ERBB4
UniProt: Q15303 (ERBB4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.59
Assay: Binding constant for ERBB4 kinase domain
Drug: bosutinib
Target: High affinity nerve growth factor receptor (Kinase)
Gene: NTRK1
UniProt: P04629 (NTRK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.51
Assay: Binding constant for TRKA kinase domain
Drug: bosutinib
Target: Protein kinase C delta type (Kinase)
Gene: PRKCD
UniProt: Q05655 (KPCD_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.8
Assay: Binding constant for PRKCD kinase domain
Drug: bosutinib
Target: Tyrosine-protein kinase JAK2 (Kinase)
Gene: JAK2
UniProt: O60674 (JAK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.96
Assay: Binding constant for JAK2(JH1domain-catalytic) kinase domain
Drug: bosutinib
Target: Rho-associated protein kinase 2 (Kinase)
Gene: ROCK2
UniProt: O75116 (ROCK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.44
Assay: Binding constant for ROCK2 kinase domain
Drug: bosutinib
Target: Tyrosine-protein kinase SYK (Kinase)
Gene: SYK
UniProt: P43405 (KSYK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.54
Assay: Binding constant for SYK kinase domain
Drug: bosutinib
Target: Tyrosine-protein kinase CSK (Kinase)
Gene: CSK
UniProt: P41240 (CSK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.49
Assay: Binding constant for CSK kinase domain
Drug: bosutinib
Target: Angiopoietin-1 receptor (Kinase)
Gene: TEK
UniProt: Q02763 (TIE2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.41
Assay: Binding constant for TIE2 kinase domain
Drug: bosutinib
Target: Ephrin type-A receptor 8 (Kinase)
Gene: EPHA8
UniProt: P29322 (EPHA8_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.05
Assay: Binding constant for EPHA8 kinase domain
Drug: bosutinib
Target: Calcium/calmodulin-dependent protein kinase type II subunit gamma (Kinase)
Gene: CAMK2G
UniProt: Q13555 (KCC2G_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.44
Assay: Binding constant for CAMK2G kinase domain
Drug: bosutinib
Target: AP2-associated protein kinase 1 (Kinase)
Gene: AAK1
UniProt: Q2M2I8 (AAK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.64
Assay: Binding constant for AAK1 kinase domain
Drug: bosutinib
Target: Hepatocyte growth factor receptor (Kinase)
Gene: MET
UniProt: P08581 (MET_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.66
Assay: Binding constant for MET kinase domain
Drug: bosutinib
Target: Tyrosine-protein kinase Lyn (Kinase)
Gene: LYN
UniProt: P07948 (LYN_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.38
Action type: INHIBITOR
Assay: Binding constant for LYN kinase domain
Drug: bosutinib
Target: Cytoplasmic tyrosine-protein kinase BMX (Kinase)
Gene: BMX
UniProt: P51813 (BMX_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.7
Assay: Binding constant for BMX kinase domain
Drug: bosutinib
Target: Serine/threonine-protein kinase Nek2 (Kinase)
Gene: NEK2
UniProt: P51955 (NEK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.8
Assay: Binding constant for NEK2 kinase domain
Drug: bosutinib
Target: Ribosomal protein S6 kinase alpha-2 (Kinase)
Gene: RPS6KA2
UniProt: Q15349 (KS6A2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.49
Assay: Binding constant for RSK3(Kin.Dom.1-N-terminal) kinase domain
Drug: bosutinib
Target: 5'-AMP-activated protein kinase catalytic subunit alpha-1 (Kinase)
Gene: PRKAA1
UniProt: Q13131 (AAPK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.41
Assay: Binding constant for AMPK-alpha1 kinase domain
Drug: bosutinib
Target: Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform (Kinase)
Gene: PHKG1
UniProt: Q16816 (PHKG1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.47
Assay: Binding constant for PHKG1 kinase domain
Drug: bosutinib
Target: Calcium/calmodulin-dependent protein kinase type II subunit alpha (Kinase)
Gene: CAMK2A
UniProt: Q9UQM7 (KCC2A_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.35
Assay: Binding constant for CAMK2A kinase domain
Drug: bosutinib
Target: Serine/threonine-protein kinase 10 (Kinase)
Gene: STK10
UniProt: O94804 (STK10_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.15
Assay: Binding constant for LOK kinase domain
Drug: bosutinib
Target: Tyrosine-protein kinase Fer (Kinase)
Gene: FER
UniProt: P16591 (FER_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.44
Assay: Binding constant for FER kinase domain
Drug: bosutinib
Target: Protein kinase C epsilon type (Kinase)
Gene: PRKCE
UniProt: Q02156 (KPCE_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.62
Assay: Binding constant for PRKCE kinase domain
Drug: bosutinib
Target: Abelson tyrosine-protein kinase 2 (Kinase)
Gene: ABL2
UniProt: P42684 (ABL2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.82
Assay: Binding constant for ABL2 kinase domain
Drug: bosutinib
Target: Ephrin type-A receptor 5 (Kinase)
Gene: EPHA5
UniProt: P54756 (EPHA5_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.57
Assay: Binding constant for EPHA5 kinase domain
Drug: bosutinib
Target: Ephrin type-A receptor 4 (Kinase)
Gene: EPHA4
UniProt: P54764 (EPHA4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.74
Assay: Binding constant for EPHA4 kinase domain
Drug: bosutinib
Target: Serine/threonine-protein kinase N1 (Kinase)
Gene: PKN1
UniProt: Q16512 (PKN1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.54
Assay: Binding constant for PKN1 kinase domain
Drug: bosutinib
Target: Protein kinase C theta type (Kinase)
Gene: PRKCQ
UniProt: Q04759 (KPCT_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.04
Assay: Binding constant for PRKCQ kinase domain
Drug: bosutinib
Target: Ephrin type-A receptor 6 (Kinase)
Gene: EPHA6
UniProt: Q9UF33 (EPHA6_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.96
Assay: Binding constant for EPHA6 kinase domain
Drug: bosutinib
Target: TRAF2 and NCK-interacting protein kinase (Kinase)
Gene: TNIK
UniProt: Q9UKE5 (TNIK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.51
Assay: Binding constant for TNIK kinase domain
Drug: bosutinib
Target: Casein kinase I isoform epsilon (Kinase)
Gene: CSNK1E
UniProt: P49674 (KC1E_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.96
Assay: Binding constant for CSNK1E kinase domain
Drug: bosutinib
Target: Tyrosine-protein kinase Fgr (Kinase)
Gene: FGR
UniProt: P09769 (FGR_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.2
Assay: Binding constant for FGR kinase domain
Drug: bosutinib
Target: ALK tyrosine kinase receptor (Kinase)
Gene: ALK
UniProt: Q9UM73 (ALK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.16
Assay: Binding constant for ALK kinase domain
Drug: bosutinib
Target: Serine/threonine-protein kinase 36 (Kinase)
Gene: STK36
UniProt: Q9NRP7 (STK36_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.24
Assay: Binding constant for STK36 kinase domain
Drug: bosutinib
Target: Ephrin type-A receptor 3 (Kinase)
Gene: EPHA3
UniProt: P29320 (EPHA3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.24
Assay: Binding constant for EPHA3 kinase domain
Drug: bosutinib
Target: BMP-2-inducible protein kinase (Kinase)
Gene: BMP2K
UniProt: Q9NSY1 (BMP2K_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.46
Assay: Binding constant for BIKE kinase domain
Drug: bosutinib
Target: Tyrosine-protein kinase FRK (Kinase)
Gene: FRK
UniProt: P42685 (FRK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.85
Assay: Binding constant for FRK kinase domain
Drug: bosutinib
Target: Dual specificity protein kinase CLK1 (Kinase)
Gene: CLK1
UniProt: P49759 (CLK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.22
Assay: Binding constant for CLK1 kinase domain
Drug: bosutinib
Target: Dual specificity protein kinase CLK2 (Kinase)
Gene: CLK2
UniProt: P49760 (CLK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.77
Assay: Binding constant for CLK2 kinase domain
Drug: bosutinib
Target: Dual specificity protein kinase CLK3 (Kinase)
Gene: CLK3
UniProt: P49761 (CLK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.52
Assay: Binding constant for CLK3 kinase domain
Drug: bosutinib
Target: Mitogen-activated protein kinase kinase kinase kinase 5 (Kinase)
Gene: MAP4K5
UniProt: Q9Y4K4 (M4K5_HUMAN)
Organism: Homo sapiens
Activity: Kd = 9.3
Assay: Binding constant for MAP4K5 kinase domain
Drug: bosutinib
Target: Mitogen-activated protein kinase kinase kinase 4 (Kinase)
Gene: MAP3K4
UniProt: Q9Y6R4 (M3K4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.96
Assay: Binding constant for MAP3K4 kinase domain
Drug: bosutinib
Target: Cyclin-G-associated kinase (Kinase)
Gene: GAK
UniProt: O14976 (GAK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.89
Assay: Binding constant for GAK kinase domain
Drug: bosutinib
Target: Receptor-interacting serine/threonine-protein kinase 2 (Kinase)
Gene: RIPK2
UniProt: O43353 (RIPK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.43
Assay: Binding constant for RIPK2 kinase domain
Drug: bosutinib
Target: Ephrin type-B receptor 1 (Kinase)
Gene: EPHB1
UniProt: P54762 (EPHB1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.48
Assay: Binding constant for EPHB1 kinase domain
Drug: bosutinib
Target: Calcium/calmodulin-dependent protein kinase type 1D (Kinase)
Gene: CAMK1D
UniProt: Q8IU85 (KCC1D_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.26
Assay: Binding constant for CAMK1D kinase domain
Drug: bosutinib
Target: Cyclin-dependent kinase 16 (Kinase)
Gene: CDK16
UniProt: Q00536 (CDK16_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.62
Assay: Binding constant for PCTK1 kinase domain
Drug: bosutinib
Target: Serine/threonine-protein kinase 4 (Kinase)
Gene: STK4
UniProt: Q13043 (STK4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.72
Assay: Binding constant for MST1 kinase domain
Drug: bosutinib
Target: Activated CDC42 kinase 1 (Kinase)
Gene: TNK2
UniProt: Q07912 (ACK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.54
Assay: Binding constant for TNK2 kinase domain
Drug: bosutinib
Target: STE20-like serine/threonine-protein kinase (Kinase)
Gene: SLK
UniProt: Q9H2G2 (SLK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.33
Assay: Binding constant for SLK kinase domain
Drug: bosutinib
Target: Dual specificity protein kinase CLK4 (Kinase)
Gene: CLK4
UniProt: Q9HAZ1 (CLK4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.49
Assay: Binding constant for CLK4 kinase domain
Drug: bosutinib
Target: Calcium/calmodulin-dependent protein kinase kinase 2 (Kinase)
Gene: CAMKK2
UniProt: Q96RR4 (KKCC2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.11
Assay: Binding constant for CAMKK2 kinase domain
Drug: bosutinib
Target: Epithelial discoidin domain-containing receptor 1 (Kinase)
Gene: DDR1
UniProt: Q08345 (DDR1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.92
Assay: Binding constant for DDR1 kinase domain
Drug: bosutinib
Target: Ephrin type-B receptor 4 (Kinase)
Gene: EPHB4
UniProt: P54760 (EPHB4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.04
Assay: Binding constant for EPHB4 kinase domain
Drug: bosutinib
Target: Testis-specific serine/threonine-protein kinase 1 (Kinase)
Gene: TSSK1B
UniProt: Q9BXA7 (TSSK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.34
Assay: Binding constant for TSSK1B kinase domain
Drug: bosutinib
Target: Cyclin-dependent kinase 15 (Kinase)
Gene: CDK15
UniProt: Q96Q40 (CDK15_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.8
Assay: Binding constant for PFTAIRE2 kinase domain
Drug: bosutinib
Target: Dual specificity mitogen-activated protein kinase kinase 7 (Kinase)
Gene: MAP2K7
UniProt: O14733 (MP2K7_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.28
Assay: Binding constant for MKK7 kinase domain
Drug: bosutinib
Target: Dual specificity mitogen-activated protein kinase kinase 1 (Kinase)
Gene: MAP2K1
UniProt: Q02750 (MP2K1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.72
Assay: Binding constant for MEK1 kinase domain
Drug: bosutinib
Target: Dual specificity mitogen-activated protein kinase kinase 2 (Kinase)
Gene: MAP2K2
UniProt: P36507 (MP2K2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8
Assay: Binding constant for MEK2 kinase domain
Drug: bosutinib
Target: Tyrosine-protein kinase ITK/TSK (Kinase)
Gene: ITK
UniProt: Q08881 (ITK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.77
Assay: Binding constant for ITK kinase domain
Drug: bosutinib
Target: Tyrosine-protein kinase ZAP-70 (Kinase)
Gene: ZAP70
UniProt: P43403 (ZAP70_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.8
Assay: Binding constant for ZAP70 kinase domain
Drug: bosutinib
Target: Tyrosine-protein kinase BTK (Kinase)
Gene: BTK
UniProt: Q06187 (BTK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.32
Assay: Binding constant for BTK kinase domain
Drug: bosutinib
Target: Tyrosine-protein kinase Tec (Kinase)
Gene: TEC
UniProt: P42680 (TEC_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.49
Assay: Binding constant for TEC kinase domain
Drug: bosutinib
Target: Tyrosine-protein kinase receptor UFO (Kinase)
Gene: AXL
UniProt: P30530 (UFO_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.28
Assay: Binding constant for AXL kinase domain
Drug: bosutinib
Target: BDNF/NT-3 growth factors receptor (Kinase)
Gene: NTRK2
UniProt: Q16620 (NTRK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.92
Assay: Binding constant for TRKB kinase domain
Drug: bosutinib
Target: Tyrosine-protein kinase receptor TYRO3 (Kinase)
Gene: TYRO3
UniProt: Q06418 (TYRO3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.21
Assay: Binding constant for TYRO3 kinase domain
Drug: bosutinib
Target: Ephrin type-B receptor 2 (Kinase)
Gene: EPHB2
UniProt: P29323 (EPHB2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.08
Assay: Binding constant for EPHB2 kinase domain
Drug: bosutinib
Target: Cyclin-dependent kinase 7 (Kinase)
Gene: CDK7
UniProt: P50613 (CDK7_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.92
Assay: Binding constant for CDK7 kinase domain
Drug: bosutinib
Target: Ribosomal protein S6 kinase beta-1 (Kinase)
Gene: RPS6KB1
UniProt: P23443 (KS6B1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.18
Assay: Binding constant for S6K1 kinase domain
Drug: bosutinib
Target: Serine/threonine-protein kinase N2 (Kinase)
Gene: PKN2
UniProt: Q16513 (PKN2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.49
Assay: Binding constant for PKN2 kinase domain
Drug: bosutinib
Target: Serine/threonine-protein kinase DCLK3 (Kinase)
Gene: DCLK3
UniProt: Q9C098 (DCLK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.27
Assay: Binding constant for DCAMKL3 kinase domain
Drug: bosutinib
Target: Serine/threonine-protein kinase 3 (Kinase)
Gene: STK3
UniProt: Q13188 (STK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.43
Assay: Binding constant for MST2 kinase domain
Drug: bosutinib
Target: Ribosomal protein S6 kinase alpha-6 (Kinase)
Gene: RPS6KA6
UniProt: Q9UK32 (KS6A6_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.57
Assay: Binding constant for RSK4(Kin.Dom.1-N-terminal) kinase domain
Drug: bosutinib
Target: NUAK family SNF1-like kinase 2 (Kinase)
Gene: NUAK2
UniProt: Q9H093 (NUAK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.66
Assay: Binding constant for SNARK kinase domain
Drug: bosutinib
Target: Non-receptor tyrosine-protein kinase TYK2 (Kinase)
Gene: TYK2
UniProt: P29597 (TYK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.35
Assay: Binding constant for TYK2(JH2domain-pseudokinase) kinase domain
Drug: bosutinib
Target: Serine/threonine-protein kinase Chk1 (Kinase)
Gene: CHEK1
UniProt: O14757 (CHK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.52
Assay: Binding constant for CHEK1 kinase domain
Drug: bosutinib
Target: Serine/threonine-protein kinase PAK 3 (Kinase)
Gene: PAK3
UniProt: O75914 (PAK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.24
Assay: Binding constant for PAK3 kinase domain
Drug: bosutinib
Target: Cyclin-dependent kinase 14 (Kinase)
Gene: CDK14
UniProt: O94921 (CDK14_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.85
Assay: Binding constant for PFTK1 kinase domain
Drug: bosutinib
Target: Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (Kinase)
Gene: PIP5K1A
UniProt: Q99755 (PI51A_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.48
Assay: Binding constant for PIP5K1A kinase domain
Drug: bosutinib
Target: Wee1-like protein kinase (Kinase)
Gene: WEE1
UniProt: P30291 (WEE1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.29
Assay: Binding constant for WEE1 kinase domain
Drug: bosutinib
Target: Serine/threonine-protein kinase 25 (Kinase)
Gene: STK25
UniProt: O00506 (STK25_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.05
Assay: Binding constant for YSK1 kinase domain
Drug: bosutinib
Target: Mitogen-activated protein kinase kinase kinase MLT (Kinase)
Gene: ZAK
UniProt: Q9NYL2 (MLTK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.1
Assay: Binding constant for ZAK kinase domain
Drug: bosutinib
Target: Protein-tyrosine kinase 2-beta (Kinase)
Gene: PTK2B
UniProt: Q14289 (FAK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.41
Assay: Binding constant for PYK2 kinase domain
Drug: bosutinib
Target: Serine/threonine-protein kinase RIO1 (Kinase)
Gene: RIOK1
UniProt: Q9BRS2 (RIOK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.66
Assay: Binding constant for RIOK1 kinase domain
Drug: bosutinib
Target: Casein kinase I isoform alpha-like (Kinase)
Gene: CSNK1A1L
UniProt: Q8N752 (KC1AL_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.59
Assay: Binding constant for CSNK1A1L kinase domain
Drug: bosutinib
Target: Casein kinase I isoform delta (Kinase)
Gene: CSNK1D
UniProt: P48730 (KC1D_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.62
Assay: Binding constant for CSNK1D kinase domain
Drug: bosutinib
Target: Tyrosine-protein kinase receptor Tie-1 (Kinase)
Gene: TIE1
UniProt: P35590 (TIE1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.54
Assay: Binding constant for TIE1 kinase domain
Drug: bosutinib
Target: Serine/threonine-protein kinase tousled-like 1 (Kinase)
Gene: TLK1
UniProt: Q9UKI8 (TLK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.24
Assay: Binding constant for TLK1 kinase domain
Drug: bosutinib
Target: Serine/threonine-protein kinase tousled-like 2 (Kinase)
Gene: TLK2
UniProt: Q86UE8 (TLK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.68
Assay: Binding constant for TLK2 kinase domain
Drug: bosutinib
Target: NT-3 growth factor receptor (Kinase)
Gene: NTRK3
UniProt: Q16288 (NTRK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.47
Assay: Binding constant for TRKC kinase domain
Drug: bosutinib
Target: Tyrosine-protein kinase TXK (Kinase)
Gene: TXK
UniProt: P42681 (TXK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.14
Assay: Binding constant for TXK kinase domain
Drug: bosutinib
Target: Inhibitor of nuclear factor kappa-B kinase subunit epsilon (Kinase)
Gene: IKBKE
UniProt: Q14164 (IKKE_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.28
Assay: Binding constant for IKK-epsilon kinase domain
Drug: bosutinib
Target: Dual specificity mitogen-activated protein kinase kinase 3 (Kinase)
Gene: MAP2K3
UniProt: P46734 (MP2K3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.59
Assay: Binding constant for MEK3 kinase domain
Drug: bosutinib
Target: Serine/threonine-protein kinase 26 (Kinase)
Gene: STK26
UniProt: Q9P289 (STK26_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.43
Assay: Binding constant for MST4 kinase domain
Drug: bosutinib
Target: Serine/threonine-protein kinase NLK (Kinase)
Gene: NLK
UniProt: Q9UBE8 (NLK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.66
Assay: Binding constant for NLK kinase domain
Drug: bosutinib
Target: Eukaryotic translation initiation factor 2-alpha kinase 4 (Kinase)
Gene: EIF2AK4
UniProt: Q9P2K8 (E2AK4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.57
Assay: Binding constant for GCN2(Kin.Dom.2,S808G) kinase domain
Drug: bosutinib
Target: Serine/threonine-protein kinase RIO3 (Kinase)
Gene: RIOK3
UniProt: O14730 (RIOK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.8
Assay: Binding constant for RIOK3 kinase domain
Drug: bosutinib
Target: Serine/threonine-protein kinase SIK2 (Kinase)
Gene: SIK2
UniProt: Q9H0K1 (SIK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.54
Assay: Binding constant for SIK2 kinase domain
Drug: bosutinib
Target: Serine/threonine-protein kinase 33 (Kinase)
Gene: STK33
UniProt: Q9BYT3 (STK33_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.43
Assay: Binding constant for STK33 kinase domain
Drug: bosutinib
Target: Serine/threonine-protein kinase TNNI3K (Kinase)
Gene: TNNI3K
UniProt: Q59H18 (TNI3K_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.77
Assay: Binding constant for TNNI3K kinase domain
Drug: bosutinib
Target: Ankyrin repeat and protein kinase domain-containing protein 1 (Kinase)
Gene: ANKK1
UniProt: Q8NFD2 (ANKK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.68
Assay: Binding constant for ANKK1 kinase domain
Drug: bosutinib
Target: Discoidin domain-containing receptor 2 (Kinase)
Gene: DDR2
UniProt: Q16832 (DDR2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.85
Assay: Binding constant for DDR2 kinase domain
Drug: bosutinib
Target: Myotonin-protein kinase (Kinase)
Gene: DMPK
UniProt: Q09013 (DMPK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.04
Assay: Binding constant for DMPK kinase domain
Drug: bosutinib
Target: Leukocyte tyrosine kinase receptor (Kinase)
Gene: LTK
UniProt: P29376 (LTK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.52
Assay: Binding constant for LTK kinase domain
Drug: bosutinib
Target: Mitogen-activated protein kinase kinase kinase kinase 1 (Kinase)
Gene: MAP4K1
UniProt: Q92918 (M4K1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.82
Assay: Binding constant for HPK1 kinase domain
Drug: bosutinib
Target: NUAK family SNF1-like kinase 1 (Kinase)
Gene: NUAK1
UniProt: O60285 (NUAK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.23
Assay: Binding constant for ARK5 kinase domain
Drug: bosutinib
Target: Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (Kinase)
Gene: PKMYT1
UniProt: Q99640 (PMYT1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.46
Assay: Binding constant for PKMYT1 kinase domain
Drug: bosutinib
Target: Mitogen-activated protein kinase kinase kinase kinase 3 (Kinase)
Gene: MAP4K3
UniProt: Q8IVH8 (M4K3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.29
Assay: Binding constant for MAP4K3 kinase domain
Drug: bosutinib
Target: Tyrosine-protein kinase Blk (Kinase)
Gene: BLK
UniProt: P51451 (BLK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.48
Assay: Binding constant for BLK kinase domain
Drug: bosutinib
Target: Bone morphogenetic protein receptor type-2 (Kinase)
Gene: BMPR2
UniProt: Q13873 (BMPR2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.24
Assay: Binding constant for BMPR2 kinase domain
Drug: bosutinib
Target: Mitogen-activated protein kinase kinase kinase kinase 4 (Kinase)
Gene: MAP4K4
UniProt: O95819 (M4K4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.09
Assay: Binding constant for MAP4K4 kinase domain