AIM-Harvard/TrialPanorama-filtered huggingface dataset:
Drug: sorafenib
Target: Fibroblast growth factor receptor 1 (Kinase)
Gene: FGFR1
UniProt: P11362 (FGFR1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.6
Assay: Average Binding Constant for FGFR1; NA=Not Active at 10 uM
Drug: sorafenib
Target: Cyclin-dependent-like kinase 5 (Kinase)
Gene: CDK5
UniProt: Q00535 (CDK5_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.21
Assay: Average Binding Constant for CDK5; NA=Not Active at 10 uM
Drug: sorafenib
Target: Serine/threonine-protein kinase 10 (Kinase)
Gene: STK10
UniProt: O94804 (STK10_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.85
Assay: Average Binding Constant for STK10; NA=Not Active at 10 uM
Drug: sorafenib
Target: Serine/threonine-protein kinase PLK4 (Kinase)
Gene: PLK4
UniProt: O00444 (PLK4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.47
Assay: Average Binding Constant for STK18; NA=Not Active at 10 uM
Drug: sorafenib
Target: Aurora kinase C (Kinase)
Gene: AURKC
UniProt: Q9UQB9 (AURKC_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.68
Assay: Binding constant for full-length AURKC
Drug: sorafenib
Target: Dual specificity protein kinase TTK (Kinase)
Gene: TTK
UniProt: P33981 (TTK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.46
Assay: Binding constant for TTK kinase domain
Drug: sorafenib
Target: Abelson tyrosine-protein kinase 2 (Kinase)
Gene: ABL2
UniProt: P42684 (ABL2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.89
Assay: Average Binding Constant for ABL2; NA=Not Active at 10 uM
Drug: sorafenib
Target: Mitogen-activated protein kinase 11 (Kinase)
Gene: MAPK11
UniProt: Q15759 (MK11_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.7
Assay: Average Binding Constant for p38-beta; NA=Not Active at 10 uM
Drug: sorafenib
Target: Ephrin type-A receptor 5 (Kinase)
Gene: EPHA5
UniProt: P54756 (EPHA5_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.44
Assay: Average Binding Constant for EPHA5; NA=Not Active at 10 uM
Drug: sorafenib
Target: Ephrin type-A receptor 4 (Kinase)
Gene: EPHA4
UniProt: P54764 (EPHA4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.89
Assay: Average Binding Constant for EPHA4; NA=Not Active at 10 uM
Drug: sorafenib
Target: Fibroblast growth factor receptor 2 (Kinase)
Gene: FGFR2
UniProt: P21802 (FGFR2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.57
Assay: Binding constant for FGFR2 kinase domain
Drug: sorafenib
Target: Mitogen-activated protein kinase 3 (Kinase)
Gene: MAPK3
UniProt: P27361 (MK03_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7.74
Drug: sorafenib
Target: Ephrin type-A receptor 6 (Kinase)
Gene: EPHA6
UniProt: Q9UF33 (EPHA6_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.62
Assay: Average Binding Constant for EPHA6; NA=Not Active at 10 uM
Drug: sorafenib
Target: TRAF2 and NCK-interacting protein kinase (Kinase)
Gene: TNIK
UniProt: Q9UKE5 (TNIK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.1
Assay: Binding constant for TNIK kinase domain
Drug: sorafenib
Target: Mitogen-activated protein kinase 12 (Kinase)
Gene: MAPK12
UniProt: P53778 (MK12_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.12
Assay: Binding constant for full-length p38-gamma
Drug: sorafenib
Target: Tyrosine-protein kinase Fgr (Kinase)
Gene: FGR
UniProt: P09769 (FGR_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.11
Assay: Binding constant for FGR kinase domain
Drug: sorafenib
Target: Aurora kinase A (Kinase)
Gene: AURKA
UniProt: O14965 (AURKA_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.42
Assay: Inhibition of recombinant GST-tagged Aurora A expressed in Sf9 insect cells after 90 mins by Kinase-Glo assay
Drug: sorafenib
Target: Serine/threonine-protein kinase 36 (Kinase)
Gene: STK36
UniProt: Q9NRP7 (STK36_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.42
Assay: Binding constant for STK36 kinase domain
Drug: sorafenib
Target: Ephrin type-A receptor 3 (Kinase)
Gene: EPHA3
UniProt: P29320 (EPHA3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.72
Assay: Binding constant for EPHA3 kinase domain
Drug: sorafenib
Target: Mitogen-activated protein kinase 14 (Kinase)
Gene: MAPK14
UniProt: Q16539 (MK14_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.59
Assay: Average Binding Constant for p38-alpha; NA=Not Active at 10 uM
Drug: sorafenib
Target: Tyrosine-protein kinase FRK (Kinase)
Gene: FRK
UniProt: P42685 (FRK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.36
Assay: Average Binding Constant for FRK; NA=Not Active at 10 uM
Drug: sorafenib
Target: Dual specificity protein kinase CLK1 (Kinase)
Gene: CLK1
UniProt: P49759 (CLK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.12
Assay: Binding constant for CLK1 kinase domain
Drug: sorafenib
Target: Mitogen-activated protein kinase kinase kinase kinase 5 (Kinase)
Gene: MAP4K5
UniProt: Q9Y4K4 (M4K5_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.8
Assay: Binding constant for MAP4K5 kinase domain
Drug: sorafenib
Target: Receptor-interacting serine/threonine-protein kinase 2 (Kinase)
Gene: RIPK2
UniProt: O43353 (RIPK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.89
Assay: Binding constant for RIPK2 kinase domain
Drug: sorafenib
Target: Ephrin type-B receptor 1 (Kinase)
Gene: EPHB1
UniProt: P54762 (EPHB1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.77
Assay: Average Binding Constant for EPHB1; NA=Not Active at 10 uM
Drug: sorafenib
Target: Ephrin type-A receptor 7 (Kinase)
Gene: EPHA7
UniProt: Q15375 (EPHA7_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.17
Assay: Average Binding Constant for EPHA7; NA=Not Active at 10 uM
Drug: sorafenib
Target: STE20-like serine/threonine-protein kinase (Kinase)
Gene: SLK
UniProt: Q9H2G2 (SLK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6
Assay: Binding constant for SLK kinase domain
Drug: sorafenib
Target: MAP kinase-interacting serine/threonine-protein kinase 2 (Kinase)
Gene: MKNK2
UniProt: Q9HBH9 (MKNK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.89
Assay: Binding constant for MKNK2 kinase domain
Drug: sorafenib
Target: Mitogen-activated protein kinase 9 (Kinase)
Gene: MAPK9
UniProt: P45984 (MK09_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.44
Assay: Average Binding Constant for JNK2; NA=Not Active at 10 uM
Drug: sorafenib
Target: Epithelial discoidin domain-containing receptor 1 (Kinase)
Gene: DDR1
UniProt: Q08345 (DDR1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.82
Assay: Binding constant for DDR1 kinase domain
Drug: sorafenib
Target: Ephrin type-B receptor 4 (Kinase)
Gene: EPHB4
UniProt: P54760 (EPHB4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.74
Assay: Binding constant for EPHB4 kinase domain
Drug: sorafenib
Target: Cyclin-dependent kinase 15 (Kinase)
Gene: CDK15
UniProt: Q96Q40 (CDK15_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.54
Assay: Binding affinity to PFTAIRE2
Drug: sorafenib
Target: Bifunctional epoxide hydrolase 2 (Enzyme)
Gene: EPHX2
UniProt: P34913 (HYES_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7.92
Assay: Inhibition of human recombinant soluble epoxide hydrolase assessed as cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxyran-2-yl)methyl] carbonate conversion to 6-methoxy-2-naphthaldehyde preincubated for 5 mins prior to substrate addition by fluorescence assay
Drug: sorafenib
Target: TGF-beta receptor type-2 (Kinase)
Gene: TGFBR2
UniProt: P37173 (TGFR2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.16
Assay: Binding constant for TGFBR2 kinase domain
Drug: sorafenib
Target: Mitogen-activated protein kinase 1 (Kinase)
Gene: MAPK1
UniProt: P28482 (MK01_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.96
Drug: sorafenib
Target: Tyrosine-protein kinase receptor UFO (Kinase)
Gene: AXL
UniProt: P30530 (UFO_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.35
Assay: Binding constant for AXL kinase domain
Drug: sorafenib
Target: BDNF/NT-3 growth factors receptor (Kinase)
Gene: NTRK2
UniProt: Q16620 (NTRK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.68
Assay: Binding constant for TRKB kinase domain
Drug: sorafenib
Target: Ephrin type-B receptor 2 (Kinase)
Gene: EPHB2
UniProt: P29323 (EPHB2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.72
Assay: Binding constant for EPHB2 kinase domain
Drug: sorafenib
Target: Cyclin-dependent kinase 7 (Kinase)
Gene: CDK7
UniProt: P50613 (CDK7_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.85
Assay: Binding constant for full-length CDK7
Drug: sorafenib
Target: Ribosomal protein S6 kinase alpha-6 (Kinase)
Gene: RPS6KA6
UniProt: Q9UK32 (KS6A6_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.12
Assay: Binding constant for RPS6KA6(Kin.Dom.2 - N-terminal) kinase domain
Drug: sorafenib
Target: Non-receptor tyrosine-protein kinase TNK1 (Kinase)
Gene: TNK1
UniProt: Q13470 (TNK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.64
Assay: Binding constant for full-length TNK1
Drug: sorafenib
Target: Mitogen-activated protein kinase 13 (Kinase)
Gene: MAPK13
UniProt: O15264 (MK13_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.18
Assay: Binding affinity to p38-delta
Drug: sorafenib
Target: Cyclin-dependent kinase 17 (Kinase)
Gene: CDK17
UniProt: Q00537 (CDK17_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.8
Assay: Binding constant for full-length PCTK2
Drug: sorafenib
Target: Cyclin-dependent kinase 14 (Kinase)
Gene: CDK14
UniProt: O94921 (CDK14_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.54
Assay: Binding constant for full-length PFTK1
Drug: sorafenib
Target: Mitogen-activated protein kinase kinase kinase MLT (Kinase)
Gene: ZAK
UniProt: Q9NYL2 (MLTK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.2
Assay: Binding constant for ZAK kinase domain
Drug: sorafenib
Target: Tyrosine-protein kinase receptor Tie-1 (Kinase)
Gene: TIE1
UniProt: P35590 (TIE1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.17
Assay: Binding constant for TIE1 kinase domain
Drug: sorafenib
Target: NT-3 growth factor receptor (Kinase)
Gene: NTRK3
UniProt: Q16288 (NTRK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.22
Assay: Binding constant for TRKC kinase domain
Drug: sorafenib
Target: LIM domain kinase 2 (Kinase)
Gene: LIMK2
UniProt: P53671 (LIMK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.02
Assay: Binding constant for LIMK2 kinase domain
Drug: sorafenib
Target: MAP kinase-interacting serine/threonine-protein kinase 1 (Kinase)
Gene: MKNK1
UniProt: Q9BUB5 (MKNK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.64
Assay: Binding constant for full-length MKNK1
Drug: sorafenib
Target: Serine/threonine-protein kinase NLK (Kinase)
Gene: NLK
UniProt: Q9UBE8 (NLK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.19
Assay: Binding constant for full-length NLK
Drug: sorafenib
Target: Serine/threonine-protein kinase 33 (Kinase)
Gene: STK33
UniProt: Q9BYT3 (STK33_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.62
Assay: Binding constant for full-length STK33
Drug: sorafenib
Target: Serine/threonine-protein kinase TNNI3K (Kinase)
Gene: TNNI3K
UniProt: Q59H18 (TNI3K_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.55
Assay: Binding constant for full-length TNNI3K
Drug: sorafenib
Target: Discoidin domain-containing receptor 2 (Kinase)
Gene: DDR2
UniProt: Q16832 (DDR2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.18
Assay: Binding constant for DDR2 kinase domain
Drug: sorafenib
Target: Mitogen-activated protein kinase kinase kinase kinase 1 (Kinase)
Gene: MAP4K1
UniProt: Q92918 (M4K1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.32
Assay: Binding constant for HPK1 kinase domain
Drug: sorafenib
Target: Aurora kinase B (Kinase)
Gene: AURKB
UniProt: Q96GD4 (AURKB_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.36
Assay: Binding constant for AURKB kinase domain
Drug: sorafenib
Target: Mitogen-activated protein kinase kinase kinase kinase 4 (Kinase)
Gene: MAP4K4
UniProt: O95819 (M4K4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.32
Assay: Binding constant for MAP4K4 kinase domain
Drug: sorafenib
Target: Tyrosine-protein kinase Mer (Kinase)
Gene: MERTK
UniProt: Q12866 (MERTK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.44
Assay: Binding constant for MERTK kinase domain
Drug: sorafenib
Target: Cyclin-dependent kinase 19 (Kinase)
Gene: CDK19
UniProt: Q9BWU1 (CDK19_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.6
Assay: Binding constant for CDK11 kinase domain
Drug: sorafenib
Target: Cyclin-dependent kinase 8 (Kinase)
Gene: CDK8
UniProt: P49336 (CDK8_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.51
Assay: Binding constant for CDK8 kinase domain
Drug: sorafenib
Target: Muscle, skeletal receptor tyrosine-protein kinase (Kinase)
Gene: MUSK
UniProt: O15146 (MUSK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.89
Assay: Binding constant for MUSK kinase domain
Drug: sorafenib
Target: Citron Rho-interacting kinase (Kinase)
Gene: CIT
UniProt: O14578 (CTRO_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.21
Assay: Binding constant for CIT kinase domain
Drug: sorafenib
Target: Myosin-IIIb (Kinase)
Gene: MYO3B
UniProt: Q8WXR4 (MYO3B_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.15
Assay: Binding constant for MYO3B kinase domain
Drug: sorafenib
Target: Cyclin-dependent kinase 3 (Kinase)
Gene: CDK3
UniProt: Q00526 (CDK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.42
Assay: Binding constant for CDK3 kinase domain
Drug: sorafenib
Target: Tyrosine-protein kinase Srms (Kinase)
Gene: SRMS
UniProt: Q9H3Y6 (SRMS_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.01
Assay: Binding constant for SRMS kinase domain
Drug: sorafenib
Target: Ephrin type-A receptor 1 (Kinase)
Gene: EPHA1
UniProt: P21709 (EPHA1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.51
Assay: Binding constant for EPHA1 kinase domain
Drug: sorafenib
Target: Mitogen-activated protein kinase 15 (Kinase)
Gene: MAPK15
UniProt: Q8TD08 (MK15_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.34
Assay: Binding constant for ERK8 kinase domain
Drug: sorafenib
Target: Receptor-interacting serine/threonine-protein kinase 1 (Kinase)
Gene: RIPK1
UniProt: Q13546 (RIPK1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.82
Assay: Inhibition of RIPK1 (unknown origin)
Drug: sorafenib
Target: Tyrosine-protein kinase ABL1 (Kinase)
Gene: Abl1
UniProt: P00520 (ABL1_MOUSE)
Organism: Mus musculus
Activity: IC50 = 6.65
Assay: Inhibition of mouse recombinant N-terminal His6-tagged Abl by radiometric kinase assay
Drug: sorafenib
Target: Casein kinase I isoform alpha (Kinase)
Gene: CSNK1A1
UniProt: P48729 (KC1A_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.6
Assay: Inhibition of recombinant CK1 by radioactive phosphotransfer assay in presence of 10 uM ATP
Drug: sorafenib
Target: Cyclin-dependent kinase-like 2 (Kinase)
Gene: CDKL2
UniProt: Q92772 (CDKL2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.89
Assay: Binding affinity to CDKL2
Drug: sorafenib
Target: Cyclin-dependent kinase-like 3 (Kinase)
Gene: CDKL3
UniProt: Q8IVW4 (CDKL3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.31
Assay: Binding affinity to CDKL3
Drug: sorafenib
Target: Ephrin type-B receptor 6 (Kinase)
Gene: EPHB6
UniProt: O15197 (EPHB6_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.62
Assay: Binding affinity to EPHB6
Drug: sorafenib
Target: Homeodomain-interacting protein kinase 2 (Kinase)
Gene: HIPK2
UniProt: Q9H2X6 (HIPK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.77
Assay: Binding affinity to HIPK2
Drug: sorafenib
Target: Homeodomain-interacting protein kinase 3 (Kinase)
Gene: HIPK3
UniProt: Q9H422 (HIPK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.41
Assay: Binding affinity to HIPK3
Drug: sorafenib
Target: Homeodomain-interacting protein kinase 4 (Kinase)
Gene: HIPK4
UniProt: Q8NE63 (HIPK4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.57
Assay: Binding affinity to HIPK4
Drug: sorafenib
Target: Mitogen-activated protein kinase kinase kinase 7 (Kinase)
Gene: MAP3K7
UniProt: O43318 (M3K7_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.16
Assay: Binding affinity to TAK1
Drug: sorafenib
Target: Serine/threonine-protein kinase TAO1 (Kinase)
Gene: TAOK1
UniProt: Q7L7X3 (TAOK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.27
Assay: Binding affinity to TAO1
Drug: sorafenib
Target: Serine/threonine-protein kinase TAO3 (Kinase)
Gene: TAOK3
UniProt: Q9H2K8 (TAOK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.57
Assay: Binding affinity to TAOK3
Drug: sorafenib
Target: Mitogen-activated protein kinase kinase kinase 19 (Kinase)
Gene: MAP3K19
UniProt: Q56UN5 (M3K19_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7
Assay: Binding affinity to YSK4
Drug: sorafenib
Target: Homeodomain-interacting protein kinase 1 (Kinase)
Gene: HIPK1
UniProt: Q86Z02 (HIPK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.96
Assay: Binding affinity to HIPK1
Drug: sorafenib
Target: Serine/threonine-protein kinase TAO2 (Kinase)
Gene: TAOK2
UniProt: Q9UL54 (TAOK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.27
Assay: Binding constant for TAOK2 kinase domain
Drug: sorafenib
Target: Dual specificity mitogen-activated protein kinase kinase 5 (Kinase)
Gene: MAP2K5
UniProt: Q13163 (MP2K5_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.72
Assay: Binding constant for MEK5 kinase domain
Drug: sorafenib
Target: Myosin light chain kinase 3 (Kinase)
Gene: MYLK3
UniProt: Q32MK0 (MYLK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.02
Assay: Binding constant for MLCK kinase domain
Drug: sorafenib
Target: Calcium-dependent protein kinase 1 (Kinase)
Gene: CPK1
UniProt: P62344 (CDPK1_PLAF7)
Organism: Plasmodium falciparum
Activity: Kd = 6.66
Assay: Binding constant for PFCDPK1(P.falciparum) kinase domain
Drug: sorafenib
Target: Vascular endothelial growth factor receptor 2 (Kinase)
Gene: Kdr
UniProt: P35918 (VGFR2_MOUSE)
Organism: Mus musculus
Activity: IC50 = 7.82
Assay: Inhibition of mouse FLK1 (785 to 1367 residues) expressed in sf9 cells after 1.5 to 2 hrs by TR-FRET assay
Drug: sorafenib
Target: Vascular endothelial growth factor receptor 2 (Kinase)
Gene: kdr
UniProt: Q5GIT4 (VGFR2_DANRE)
Organism: Danio rerio
Activity: IC50 = 5.59
Assay: Inhibition of VEGFR2 in transgenic zebrafish embryo assessed as inhibition of intersegmental vessels formation measured 33 hrs post fertilization by fluorescence microscopic analysis
Drug: sorafenib
Target: Serine/threonine-protein kinase A-Raf (Kinase)
Gene: ARAF
UniProt: P10398 (ARAF_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 8.15
Assay: Inhibition of ARAF (unknown origin) using human His6-tagged MEK1 K97R mutant as substrate pretreated for 20 mins followed by [33P]-ATP addition measured after 2 hrs by filter binding method
Drug: sorafenib
Target: Purine nucleoside phosphorylase (Enzyme)
Gene: PNP
UniProt: Q8T9Z7 (Q8T9Z7_PLAFA)
Organism: Plasmodium falciparum
Activity: IC50 = 7.9
Drug: sorafenib
Target: Vascular endothelial growth factor receptor 3 (Kinase)
Gene: Flt4
UniProt: P35917 (VGFR3_MOUSE)
Organism: Mus musculus
Activity: IC50 = 7.7
Action type: INHIBITOR
Drug: sorafenib
Target: Platelet-derived growth factor receptor beta (Kinase)
Gene: Pdgfrb
UniProt: P05622 (PGFRB_MOUSE)
Organism: Mus musculus
Activity: IC50 = 7.24
Action type: INHIBITOR
Drug: sorafenib
Target: Receptor-interacting serine/threonine-protein kinase 3 (Kinase)
Gene: RIPK3
UniProt: Q9Y572 (RIPK3_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.84
Assay: Inhibition of human full length N-terminal GST-tagged RIPK3 expressed in baculovirus infected sf9 insect cells assessed as reduction in MBP phosphorylation using MBP as substrate by kinase-Glo luminescence assay
Drug: sorafenib
Target: Serine/threonine-protein kinase B-raf (Kinase)
Gene: Braf
UniProt: P28028 (BRAF_MOUSE)
Organism: Mus musculus
Activity: IC50 = 6.89
Assay: Inhibition of mouse full length GST-tagged BRAF V600E mutant using recombinant human full length N-terminal His-tagged MEK1 as substrate preincubated for 1 hr followed by substrate addition measured after 25 mins by Nu-page gel-based phosphor screen analysis
Drug: sorivudine
Target: Thymidine kinase (Kinase)
Gene: TK
UniProt: Q9QNF7 (KITH_HHV1)
Organism: Human herpesvirus 1
Activity: IC50 = 5.44
Assay: Inhibition of HSV1 TK assessed as [methyl-3H]dThd phosphorylation
Drug: sorivudine
Target: Thymidine kinase (Kinase)
UniProt: P09250 (KITH_VZVD)
Organism: Varicella-zoster virus (strain Dumas)
Activity: IC50 = 5.49
Assay: Inhibition of VZV TK assessed as [methyl-3H]dThd phosphorylation
Drug: sorivudine
Target: Deoxynucleoside kinase (Kinase)
Gene: dnk
UniProt: Q9XZT6 (DNK_DROME)
Organism: Drosophila melanogaster
Activity: IC50 = 4.55
Assay: Inhibition of Drosophila melanogaster dNK assessed as [methyl-3H]dThd phosphorylation
Drug: sorivudine
Target: Thymidine kinase, mitochondrial (Kinase)
Gene: TK2
UniProt: O00142 (KITM_HUMAN)
Organism: Homo sapiens
Activity: Ki = 4.98
Assay: Inhibition of thymidine kinase 2
Drug: sotalol
Target: Beta-1 adrenergic receptor (GPCR)
Gene: ADRB1
UniProt: P08588 (ADRB1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.1
Action type: ANTAGONIST
Drug: sotalol
Target: Beta-2 adrenergic receptor (GPCR)
Gene: ADRB2
UniProt: P07550 (ADRB2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.9
Action type: ANTAGONIST
Drug: sotalol
Target: Potassium voltage-gated channel subfamily H member 2 (Ion channel)
Gene: KCNH2
UniProt: Q12809 (KCNH2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 4
Action type: BLOCKER
Drug: sotalol
Target: Beta-2 adrenergic receptor (GPCR)
Gene: ADRB2
UniProt: Q28044 (ADRB2_BOVIN)
Organism: Bos taurus
Activity: Kd = 6.24
Assay: Affinity for cow beta-2 adrenergic receptor by measuring displacement (-)-[3H]dihydroalprenolol (DHA)
Drug: sotalol
Target: Beta-2 adrenergic receptor (GPCR)
Gene: ADRB2
UniProt: P54833 (ADRB2_CANFA)
Organism: Canis familiaris
Activity: IC50 = 5.3
Assay: In vitro Beta-2 adrenergic receptor affinity in partially purified membrane fractions from canine lung tissue using [SH]dihydroalprenolol (4.5 nM)
Drug: sparfloxacin
Target: Potassium voltage-gated channel subfamily H member 2 (Ion channel)
Gene: KCNH2
UniProt: Q12809 (KCNH2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 4.413
Assay: DRUGMATRIX: Potassium Channel HERG radioligand binding (ligand: [3H] Astemizole)
Drug: sparfloxacin
Target: Topoisomerase IV (Enzyme)
Gene: parC|parE
UniProt: P0AFI2|P20083 (PARC_ECOLI|PARE_ECOLI)
Organism: Escherichia coli (strain K12)
Action type: INHIBITOR
Assay: Mechanism of Action; CHEMBL2363076; PROTEIN COMPLEX
Drug: sparfloxacin
Target: DNA gyrase (Enzyme)
Gene: gyrA|gyrB
UniProt: P0AES4|P0AES6 (GYRA_ECOLI|GYRB_ECOLI)
Organism: Escherichia coli (strain K12)
Action type: INHIBITOR
Assay: Mechanism of Action; CHEMBL2311224; PROTEIN COMPLEX
Drug: spectinomycin
Target: 30S ribosomal protein S12 (Cytosolic other)
Gene: rpsL
UniProt: P0A7S3 (RS12_ECOLI)
Organism: Escherichia coli (strain K12)
Drug: spiclomazine
Target: Beta-secretase 1 (Enzyme)
Gene: BACE1
UniProt: P56817 (BACE1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.18
Assay: Inhibition of human BACE-1 preincubated for 1 hr followed by substrate addition measured after 60 mins by FRET assay
Drug: spiperone
Target: D(1A) dopamine receptor (GPCR)
Gene: DRD1
UniProt: P21728 (DRD1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.49
Assay: Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey
Drug: spiperone
Target: D(2) dopamine receptor (GPCR)
Gene: DRD2
UniProt: P14416 (DRD2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 10.22
Action type: ANTAGONIST
Assay: Binding affinity against dopamine receptor D2 by using [3H]spiperone as radioligand in caudate-putamen of monkey
Drug: spiperone
Target: Sigma non-opioid intracellular receptor 1 (Membrane receptor)
Gene: SIGMAR1
UniProt: Q99720 (SGMR1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.02
Assay: The compound was tested for affinity towards sigma-3 receptor
Drug: spiperone
Target: 5-hydroxytryptamine receptor 1A (GPCR)
Gene: HTR1A
UniProt: P08908 (5HT1A_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.4
Assay: Binding affinity to 5HT1A receptor
Drug: spiperone
Target: 5-hydroxytryptamine receptor 2A (GPCR)
Gene: HTR2A
UniProt: P28223 (5HT2A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.65
Action type: ANTAGONIST
Assay: Displacement of [3H]Ketanserin from human 5HT2A receptor expressed in HEK293 cells
Drug: spiperone
Target: 5-hydroxytryptamine receptor 2B (GPCR)
Gene: HTR2B
UniProt: P41595 (5HT2B_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.5
Action type: ANTAGONIST
Drug: spiperone
Target: 5-hydroxytryptamine receptor 2C (GPCR)
Gene: HTR2C
UniProt: P28335 (5HT2C_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.94
Assay: Evaluated for the binding affinity to porcine choroid plexus at 5-hydroxytryptamine 2C receptor binding site by using [3H]-MES as a radioligand.