AIM-Harvard/TrialPanorama-filtered huggingface dataset:
Drug: grazoprevir
Target: NS3 protease (Unclassified)
Gene: NS3
UniProt: Q0ZMF1 (Q0ZMF1_9HEPC)
Organism: Hepatitis C virus subtype 1b
Activity: IC50 = 10.15
Assay: Inhibition of Hepatitis C virus genotype 1b NS3/4A protease R155K mutant assessed as substrate cleavage using Ac-C(Eu)DDMEEAbu(COO)ASK(QSY7)-amide as substrate incubated for 30 mins prior to substrate addition by time-resolved fluorescence assay
Drug: grazoprevir
Target: Genome polyprotein (Polyprotein)
UniProt: P26663 (POLG_HCVBK)
Organism: Hepatitis C virus genotype 1b (isolate BK)
Activity: EC50 = 12.301
Action type: INHIBITOR
Assay: Mechanism of Action
Drug: grazoprevir
Target: Genome polyprotein (Polyprotein)
UniProt: P27958 (POLG_HCVH)
Organism: Hepatitis C virus genotype 1a (isolate H)
Activity: EC50 = 12.398
Action type: INHIBITOR
Assay: Mechanism of Action
Drug: grazoprevir
Target: Genome polyprotein (Polyprotein)
UniProt: O39929 (POLG_HCVED)
Organism: Hepatitis C virus genotype 4a (isolate ED43)
Activity: EC50 = 12.523
Action type: INHIBITOR
Assay: Mechanism of Action
Drug: ixekizumab
Target: Interleukin-17A (Cytokine)
Gene: IL17A
UniProt: Q16552 (IL17_HUMAN)
Organism: Homo sapiens
Action type: ANTIBODY BINDING
Assay: Mechanism of Action
Drug: denileukin diftitox
Target: Interleukin-2 receptor (Membrane receptor)
Gene: IL2RA|IL2RB|IL2RG
UniProt: P01589|P14784|P31785 (IL2RA_HUMAN|IL2RB_HUMAN|IL2RG_HUMAN)
Organism: Homo sapiens
Action type: ANTIBODY BINDING
Assay: Mechanism of Action
Drug: alefacept
Target: T-cell surface antigen CD2 (Surface antigen)
Gene: CD2
UniProt: P06729 (CD2_HUMAN)
Organism: Homo sapiens
Action type: INHIBITOR
Assay: Mechanism of Action
Drug: abatacept
Target: T-lymphocyte activation antigen CD80 (Surface antigen)
Gene: CD80
UniProt: P33681 (CD80_HUMAN)
Organism: Homo sapiens
Activity: Kd ~ 7.92
Action type: INHIBITOR
Assay: Measuring binding of <sup>125</sup>I-labeled B7Ig fusion protein to immobilized abatacept.
Drug: abatacept
Target: T-lymphocyte activation antigen CD86 (Surface antigen)
Gene: CD86
UniProt: P42081 (CD86_HUMAN)
Organism: Homo sapiens
Activity: Kd ~ 7.92
Action type: INHIBITOR
Assay: Measuring binding of <sup>125</sup>I-labeled B7Ig fusion protein to immobilized abatacept.
Drug: belatacept
Target: T-lymphocyte activation antigen CD80 (Surface antigen)
Gene: CD80
UniProt: P33681 (CD80_HUMAN)
Organism: Homo sapiens
Action type: INHIBITOR
Assay: Mechanism of Action
Drug: belatacept
Target: T-lymphocyte activation antigen CD86 (Surface antigen)
Gene: CD86
UniProt: P42081 (CD86_HUMAN)
Organism: Homo sapiens
Action type: INHIBITOR
Assay: Mechanism of Action
Drug: reslizumab
Target: Interleukin-5 (Cytokine)
Gene: IL5
UniProt: P05113 (IL5_HUMAN)
Organism: Homo sapiens
Activity: Kd = 10.092
Action type: ANTIBODY BINDING
Assay: Mechanism of Action
Drug: obiltoxaximab
Target: Protective antigen (Secreted)
Gene: pagA
UniProt: P13423 (PAG_BACAN)
Organism: Bacillus anthracis
Activity: Kd = 9.481
Action type: ANTIBODY BINDING
Assay: Mechanism of Action
Drug: rilonacept
Target: Interleukin-1 alpha (Cytokine)
Gene: IL1A
UniProt: P01583 (IL1A_HUMAN)
Organism: Homo sapiens
Activity: Kd = 11.854
Action type: INHIBITOR
Drug: rilonacept
Target: Interleukin-1 receptor antagonist protein (Unclassified)
Gene: IL1RN
UniProt: P18510 (IL1RA_HUMAN)
Organism: Homo sapiens
Activity: Kd = 11.215
Action type: INHIBITOR
Drug: rilonacept
Target: Interleukin-1 beta (Cytokine)
Gene: IL1B
UniProt: P01584 (IL1B_HUMAN)
Organism: Homo sapiens
Activity: Kd = 12.301
Action type: INHIBITOR
Assay: Mechanism of Action
Drug: urokinase
Target: Plasminogen (Enzyme)
Gene: PLG
UniProt: P00747 (PLMN_HUMAN)
Organism: Homo sapiens
Action type: ACTIVATOR
Assay: Mechanism of Action
Drug: migalastat
Target: Maltase-glucoamylase, intestinal (Enzyme)
Gene: MGAM
UniProt: O43451 (MGA_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.82
Drug: migalastat
Target: Lysosomal alpha-glucosidase (Enzyme)
Gene: GAA
UniProt: P10253 (LYAG_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.22
Drug: migalastat
Target: Non-lysosomal glucosylceramidase (Enzyme)
Gene: GBA2
UniProt: Q9HCG7 (GBA2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4
Drug: migalastat
Target: Sucrase-isomaltase, intestinal (Enzyme)
Gene: SI
UniProt: P14410 (SUIS_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.59
Drug: migalastat
Target: Glycogen debranching enzyme (Enzyme)
Gene: AGL
UniProt: P35573 (GDE_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5
Drug: migalastat
Target: Lactase-phlorizin hydrolase (Enzyme)
Gene: LCT
UniProt: P09848 (LPH_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.3
Drug: migalastat
Target: Beta-galactosidase (Enzyme)
Gene: GLB1
UniProt: P16278 (BGAL_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.05
Drug: migalastat
Target: Beta-galactosidase (Enzyme)
Gene: lacZ
UniProt: Q59750 (BGAL_RHIML)
Organism: Rhizobium meliloti
Activity: Ki = 4.9
Drug: migalastat
Target: Lactase-phlorizin hydrolase (Enzyme)
Gene: Lct
UniProt: Q02401 (LPH_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 4.14
Drug: migalastat
Target: Alpha-galactosidase C (Enzyme)
Gene: aglC
UniProt: Q9UUZ4 (AGALC_ASPNG)
Organism: Aspergillus niger
Activity: IC50 = 5.74
Drug: migalastat
Target: Alpha-galactosidase (Enzyme)
UniProt: Q42656 (AGAL_COFAR)
Organism: Coffea arabica
Activity: IC50 = 8.52
Drug: migalastat
Target: Beta-galactosidase (Enzyme)
Gene: Glb1
UniProt: D3ZUM4 (D3ZUM4_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 4.62
Drug: migalastat
Target: Beta-galactosidase (Enzyme)
Gene: lacZ
UniProt: Q8VNN2 (BGAL_ECOLX)
Organism: Escherichia coli
Activity: Ki = 4.89
Assay: Inhibition of Escherichia coli beta-galactosidase
Drug: migalastat
Target: Alpha-galactosidase A (Enzyme)
Gene: GLA
UniProt: P06280 (AGAL_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7.15
Action type: PHARMACOLOGICAL CHAPERONE
Drug: chromic chloride
Target: Epidermal growth factor receptor (Kinase)
Gene: EGFR
UniProt: P00533 (EGFR_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.53
Drug: chromic chloride
Target: Tyrosine-protein kinase Fyn (Kinase)
Gene: FYN
UniProt: P06241 (FYN_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.76
Drug: venetoclax
Target: Bcl-2-like protein 1 (Cytosolic other)
Gene: BCL2L1
UniProt: Q07817 (B2CL1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.319
Action type: INHIBITOR
Drug: venetoclax
Target: Apoptosis regulator Bcl-W (Cytosolic other)
Gene: BCL2L2
UniProt: Q92843 (B2CL2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.611
Action type: INHIBITOR
Drug: venetoclax
Target: Apoptosis regulator Bcl-2 (Cytosolic other)
Gene: BCL2
UniProt: P10415 (BCL2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 11
Action type: INHIBITOR
Assay: Mechanism of Action
Drug: peginterferon beta-1a
Target: Interferon alpha/beta receptor (Membrane receptor)
Gene: IFNAR1|IFNAR2
UniProt: P17181|P48551 (INAR1_HUMAN|INAR2_HUMAN)
Organism: Homo sapiens
Action type: AGONIST
Assay: Mechanism of Action
Drug: interferon beta-1a
Target: Interferon alpha/beta receptor (Membrane receptor)
Gene: IFNAR1|IFNAR2
UniProt: P17181|P48551 (INAR1_HUMAN|INAR2_HUMAN)
Organism: Homo sapiens
Action type: AGONIST
Assay: Mechanism of Action
Drug: interferon beta-1b
Target: Interferon alpha/beta receptor (Membrane receptor)
Gene: IFNAR1|IFNAR2
UniProt: P17181|P48551 (INAR1_HUMAN|INAR2_HUMAN)
Organism: Homo sapiens
Action type: AGONIST
Assay: Mechanism of Action
Drug: alteplase
Target: Plasminogen (Enzyme)
Gene: PLG
UniProt: P00747 (PLMN_HUMAN)
Organism: Homo sapiens
Action type: ACTIVATOR
Assay: Mechanism of Action
Drug: pimavanserin
Target: 5-hydroxytryptamine receptor 2C (GPCR)
Gene: HTR2C
UniProt: P28335 (5HT2C_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.8
Action type: INVERSE AGONIST
Assay: 3 nM [3H]mesulergine binding in cell membranes
Drug: pimavanserin
Target: 5-hydroxytryptamine receptor 2A (GPCR)
Gene: HTR2A
UniProt: P28223 (5HT2A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 9.3
Action type: INVERSE AGONIST
Assay: 1 nM [3H]ketanserin binding in cell membranes
Drug: opicapone
Target: Catechol O-methyltransferase (Enzyme)
Gene: Comt
UniProt: P22734 (COMT_RAT)
Organism: Rattus norvegicus
Activity: Ki = 8.82
Action type: INHIBITOR
Drug: opicapone
Target: Catechol O-methyltransferase (Enzyme)
Gene: Comt
UniProt: O88587 (COMT_MOUSE)
Organism: Mus musculus
Activity: Ki = 8.82
Action type: INHIBITOR
Drug: opicapone
Target: Catechol O-methyltransferase (Enzyme)
Gene: COMT
UniProt: P21964 (COMT_HUMAN)
Organism: Homo sapiens
Activity: Ki = 9
Action type: INHIBITOR
Drug: gluconolactone
Target: Glucosylceramidase (Enzyme)
Gene: GBA
UniProt: P04062 (GLCM_HUMAN)
Organism: Homo sapiens
Activity: Ki = 4.52
Drug: choriogonadotropin alfa
Target: Lutropin-choriogonadotropic hormone receptor (GPCR)
Gene: LHCGR
UniProt: P22888 (LSHR_HUMAN)
Organism: Homo sapiens
Action type: AGONIST
Drug: atezolizumab
Target: Programmed cell death 1 ligand 1 (CD molecules)
Gene: CD274
UniProt: Q9NZQ7 (PD1L1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 9.39
Action type: ANTIBODY BINDING
Assay: Mechanism of Action
Drug: velpatasvir
Target: Nonstructural protein 5A (Unclassified)
Gene: NS5A
UniProt: Q5L478 (Q5L478_9HEPC)
Organism: Hepatitis C virus
Activity: EC50 = 11
Assay: Inhibition of NS5A N62V mutant in HCV genotype 2a infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luciferase reporter gene assay
Drug: velpatasvir
Target: Genome polyprotein (Polyprotein)
UniProt: P26663 (POLG_HCVBK)
Organism: Hepatitis C virus genotype 1b (isolate BK)
Activity: EC50 = 10.796
Action type: INHIBITOR
Drug: velpatasvir
Target: Genome polyprotein (Polyprotein)
UniProt: P27958 (POLG_HCVH)
Organism: Hepatitis C virus genotype 1a (isolate H)
Activity: EC50 = 10.854
Action type: INHIBITOR
Drug: velpatasvir
Target: Genome polyprotein (Polyprotein)
UniProt: Q99IB8 (POLG_HCVJF)
Organism: Hepatitis C virus genotype 2a (isolate JFH-1)
Activity: EC50 = 10.979
Action type: INHIBITOR
Drug: velpatasvir
Target: Genome polyprotein (Polyprotein)
UniProt: O39929 (POLG_HCVED)
Organism: Hepatitis C virus genotype 4a (isolate ED43)
Activity: EC50 = 11.046
Action type: INHIBITOR
Drug: velpatasvir
Target: Genome polyprotein (Polyprotein)
UniProt: Q81495 (POLG_HCVK3)
Organism: Hepatitis C virus genotype 3a (isolate k3a) (HCV)
Activity: EC50 = 11.398
Action type: INHIBITOR
Drug: velpatasvir
Target: Genome polyprotein (Polyprotein)
UniProt: Q9DHD6 (POLG_HCVJP)
Organism: Hepatitis C virus genotype 2b (isolate JPUT971017) (HCV)
Activity: EC50 = 11.398
Action type: INHIBITOR
Drug: velpatasvir
Target: Genome polyprotein (Polyprotein)
UniProt: O91936 (POLG_HCVSA)
Organism: Hepatitis C virus genotype 5a (isolate SA13) (HCV)
Activity: EC50 = 10.426
Action type: INHIBITOR
Drug: velpatasvir
Target: Genome polyprotein (Polyprotein)
UniProt: Q5I2N3 (POLG_HCV6A)
Organism: Hepatitis C virus genotype 6a (isolate 6a33) (HCV)
Activity: EC50 = 11.097
Action type: INHIBITOR
Drug: obeticholic acid
Target: G-protein coupled bile acid receptor 1 (GPCR)
Gene: GPBAR1
UniProt: Q8TDU6 (GPBAR_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 7
Drug: obeticholic acid
Target: Bile acid receptor (Nuclear hormone receptor)
Gene: NR1H4
UniProt: Q96RI1 (NR1H4_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 7.004
Action type: AGONIST
Assay: Mechanism of Action
Drug: darbepoetin alfa
Target: Erythropoietin receptor (Membrane receptor)
Gene: EPOR
UniProt: P19235 (EPOR_HUMAN)
Organism: Homo sapiens
Action type: AGONIST
Assay: Mechanism of Action
Drug: peginterferon alfa-2a
Target: Interferon alpha/beta receptor (Membrane receptor)
Gene: IFNAR1|IFNAR2
UniProt: P17181|P48551 (INAR1_HUMAN|INAR2_HUMAN)
Organism: Homo sapiens
Action type: AGONIST
Assay: Mechanism of Action
Drug: epoetin beta
Target: Erythropoietin receptor (Membrane receptor)
Gene: EPOR
UniProt: P19235 (EPOR_HUMAN)
Organism: Homo sapiens
Action type: AGONIST
Assay: Mechanism of Action
Drug: peginterferon alfa-2b
Target: Interferon alpha/beta receptor (Membrane receptor)
Gene: IFNAR1|IFNAR2
UniProt: P17181|P48551 (INAR1_HUMAN|INAR2_HUMAN)
Organism: Homo sapiens
Action type: AGONIST
Assay: Mechanism of Action
Drug: methoxy polyethylene glycol-epoetin beta
Target: Erythropoietin receptor (Membrane receptor)
Gene: EPOR
UniProt: P19235 (EPOR_HUMAN)
Organism: Homo sapiens
Action type: AGONIST
Assay: Mechanism of Action
Drug: lenograstim
Target: Granulocyte colony-stimulating factor receptor (Membrane receptor)
Gene: CSF3R
UniProt: Q99062 (CSF3R_HUMAN)
Organism: Homo sapiens
Action type: ACTIVATOR
Assay: Mechanism of Action
Drug: eldecalcitol
Target: Vitamin D3 receptor (Nuclear hormone receptor)
Gene: VDR
UniProt: P11473 (VDR_HUMAN)
Organism: Homo sapiens
Action type: AGONIST
Drug: eldecalcitol
Target: Vitamin D3 receptor (Transcription factor)
Gene: Vdr
UniProt: P13053 (VDR_RAT)
Organism: Rattus norvegicus
Activity: Kd = 8
Action type: AGONIST
Drug: epoetin zeta
Target: Erythropoietin receptor (Membrane receptor)
Gene: EPOR
UniProt: P19235 (EPOR_HUMAN)
Organism: Homo sapiens
Action type: AGONIST
Assay: Mechanism of Action
Drug: lifitegrast
Target: Intercellular adhesion molecule 1 (Unclassified)
Gene: ICAM1
UniProt: P05362 (ICAM1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 8.53
Drug: lifitegrast
Target: Integrin alpha-L/beta-2 (Adhesion)
Gene: ITGAL|ITGB2
UniProt: P20701|P05107 (ITAL_HUMAN|ITB2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 8.046
Action type: ANTAGONIST
Assay: inhibition of ICAM-1 binding to LFA-1 in HuT 78 cell line
Drug: muromonab-CD3
Target: T-cell surface glycoprotein CD3 (Surface antigen)
Gene: CD3E|CD3G|CD3D
UniProt: P07766|P09693|P04234 (CD3E_HUMAN|CD3G_HUMAN|CD3D_HUMAN)
Organism: Homo sapiens
Action type: ANTIBODY BINDING
Assay: Mechanism of Action
Drug: brodalumab
Target: Interleukin-17 receptor (Membrane receptor)
Gene: IL17RA|IL17RC
UniProt: Q96F46|Q8NAC3 (I17RA_HUMAN|I17RC_HUMAN)
Organism: Homo sapiens
Activity: Kd = 9.2
Action type: ANTIBODY BINDING
Drug: etelcalcetide
Target: Extracellular calcium-sensing receptor (GPCR)
Gene: CASR
UniProt: P41180 (CASR_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 4.6
Action type: AGONIST
Assay: Measuring ligand induced IP<sub>1</sub> accumulation.
Drug: eteplirsen
Target: exon 51 of dystrophin pre-mRNA (RNA)
Gene: DMD
UniProt: P11532 (DMD_HUMAN)
Organism: Homo sapiens
Action type: BINDING AGENT
Assay: Mechanism of Action
Drug: olaratumab
Target: Platelet-derived growth factor receptor alpha (Kinase)
Gene: PDGFRA
UniProt: P16234 (PGFRA_HUMAN)
Organism: Homo sapiens
Activity: Kd = 10.4
Action type: ANTIBODY BINDING
Assay: BIAcore assay
Drug: gallium (68Ga) edotreotide
Target: Somatostatin receptor type 2 (GPCR)
Gene: SSTR2
UniProt: P30874 (SSR2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.6
Action type: ANTAGONIST
Assay: Mechanism of Action
Drug: bezlotoxumab
Target: Toxin B (Enzyme)
Gene: toxB
UniProt: P18177 (TOXB_CLODI)
Organism: Clostridioides difficile
Activity: Kd = 9
Action type: ANTIBODY BINDING
Drug: radotinib
Target: Tyrosine-protein kinase ABL1 (Kinase)
Gene: ABL1
UniProt: P00519 (ABL1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7.514
Action type: INHIBITOR
Drug: crisaborole
Target: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (Enzyme)
Gene: PDE1A
UniProt: P54750 (PDE1A_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.21
Drug: crisaborole
Target: High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (Enzyme)
Gene: PDE7A
UniProt: Q13946 (PDE7A_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.14
Drug: crisaborole
Target: Phosphodiesterase 4 (Enzyme)
Gene: PDE4A|PDE4B|PDE4C|PDE4D
UniProt: P27815|Q07343|Q08493|Q08499 (PDE4A_HUMAN|PDE4B_HUMAN|PDE4C_HUMAN|PDE4D_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.31
Action type: INHIBITOR
Drug: baricitinib
Target: Tyrosine-protein kinase JAK3 (Kinase)
Gene: JAK3
UniProt: P52333 (JAK3_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.1
Drug: baricitinib
Target: AP2-associated protein kinase 1 (Kinase)
Gene: AAK1
UniProt: Q2M2I8 (AAK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.77
Action type: INHIBITOR
Assay: Binding affinity determined in a cell-free biochemical assay.
Drug: baricitinib
Target: BMP-2-inducible protein kinase (Kinase)
Gene: BMP2K
UniProt: Q9NSY1 (BMP2K_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.4
Action type: INHIBITOR
Assay: Binding affinity determined in a cell-free biochemical assay.
Drug: baricitinib
Target: Cyclin-G-associated kinase (Kinase)
Gene: GAK
UniProt: O14976 (GAK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.87
Action type: INHIBITOR
Assay: Binding affinity determined in a cell-free biochemical assay.
Drug: baricitinib
Target: Non-receptor tyrosine-protein kinase TYK2 (Kinase)
Gene: TYK2
UniProt: P29597 (TYK2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7.276
Action type: INHIBITOR
Drug: baricitinib
Target: Tyrosine-protein kinase JAK1 (Kinase)
Gene: JAK1
UniProt: P23458 (JAK1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 8.229
Action type: INHIBITOR
Drug: baricitinib
Target: Tyrosine-protein kinase JAK2 (Kinase)
Gene: JAK2
UniProt: O60674 (JAK2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 8.244
Action type: INHIBITOR
Drug: rucaparib
Target: Tankyrase-2 (Enzyme)
Gene: TNKS2
UniProt: Q9H2K2 (TNKS2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.05
Action type: INHIBITOR
Drug: rucaparib
Target: Tankyrase-1 (Enzyme)
Gene: TNKS
UniProt: O95271 (TNKS1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.84
Action type: INHIBITOR
Drug: rucaparib
Target: Poly [ADP-ribose] polymerase 4 (Enzyme)
Gene: PARP4
UniProt: Q9UKK3 (PARP4_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.08
Action type: INHIBITOR
Drug: rucaparib
Target: Poly [ADP-ribose] polymerase 10 (Enzyme)
Gene: PARP10
UniProt: Q53GL7 (PAR10_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.25
Action type: INHIBITOR
Drug: rucaparib
Target: Poly [ADP-ribose] polymerase 12 (Enzyme)
Gene: PARP12
UniProt: Q9H0J9 (PAR12_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.18
Action type: INHIBITOR
Drug: rucaparib
Target: Poly [ADP-ribose] polymerase 14 (Enzyme)
Gene: PARP14
UniProt: Q460N5 (PAR14_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.05
Action type: INHIBITOR
Drug: rucaparib
Target: Poly [ADP-ribose] polymerase 15 (Enzyme)
Gene: PARP15
UniProt: Q460N3 (PAR15_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.49
Action type: INHIBITOR
Drug: rucaparib
Target: Poly [ADP-ribose] polymerase 2 (Enzyme)
Gene: PARP2
UniProt: Q9UGN5 (PARP2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7.55
Action type: INHIBITOR
Drug: rucaparib
Target: Poly [ADP-ribose] polymerase 1 (Enzyme)
Gene: PARP1
UniProt: P09874 (PARP1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 8.5
Action type: INHIBITOR
Drug: rucaparib
Target: Poly [ADP-ribose] polymerase 3 (Enzyme)
Gene: PARP3
UniProt: Q9Y6F1 (PARP3_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.39
Action type: INHIBITOR
Drug: plecanatide
Target: Tumor necrosis factor (Cytokine)
Gene: TNF
UniProt: P01375 (TNFA_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.42
Assay: Binding affinity to TNF-alpha (unknown origin)
Drug: plecanatide
Target: Tumor necrosis factor receptor superfamily member 1A (Unclassified)
Gene: TNFRSF1A
UniProt: P19438 (TNR1A_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.66
Assay: Inhibition of TNFR1 (unknown origin)
Drug: plecanatide
Target: Heat-stable enterotoxin receptor (Enzyme)
Gene: GUCY2C
UniProt: P25092 (GUC2C_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 6.721
Action type: AGONIST
Assay: Stimulation of cGMP synthesis in T84 cells
Drug: icotinib
Target: Epidermal growth factor receptor (Kinase)
Gene: EGFR
UniProt: P00533 (EGFR_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 8.699
Action type: INHIBITOR
Drug: olmutinib
Target: Tyrosine-protein kinase BTK (Kinase)
Gene: BTK
UniProt: Q06187 (BTK_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 9
Assay: Inhibition of BTK (unknown origin)
Drug: olmutinib
Target: Epidermal growth factor receptor (Kinase)
Gene: EGFR
UniProt: P00533 (EGFR_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 8.036
Action type: INHIBITOR
Assay: HCC827 cells expressing EGFR(DEL19)
Drug: apatinib
Target: Tyrosine-protein kinase CSK (Kinase)
Gene: CSK
UniProt: P41240 (CSK_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.28
Action type: INHIBITOR
Assay: Assay used apatinib mesylate (YN968D1)
Drug: apatinib
Target: Mast/stem cell growth factor receptor Kit (Kinase)
Gene: KIT
UniProt: P10721 (KIT_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.368
Action type: INHIBITOR
Drug: apatinib
Target: Proto-oncogene tyrosine-protein kinase Src (Kinase)
Gene: SRC
UniProt: P12931 (SRC_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.276
Action type: INHIBITOR
Drug: apatinib
Target: Proto-oncogene tyrosine-protein kinase receptor Ret (Kinase)
Gene: RET
UniProt: P07949 (RET_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7.886
Action type: INHIBITOR
Drug: apatinib
Target: Vascular endothelial growth factor receptor 2 (Kinase)
Gene: KDR
UniProt: P35968 (VGFR2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 9
Action type: INHIBITOR
Drug: telotristat ethyl
Target: Tryptophan 5-hydroxylase 1 (Enzyme)
Gene: TPH1
UniProt: P17752 (TPH1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7.796
Action type: INHIBITOR
Drug: beclabuvir
Target: Potassium voltage-gated channel subfamily H member 2 (Ion channel)
Gene: KCNH2
UniProt: Q12809 (KCNH2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.61
Drug: beclabuvir
Target: RNA-directed RNA polymerase (Unclassified)
Gene: NS5b
UniProt: O39930 (O39930_9HEPC)
Organism: Hepacivirus C
Activity: IC50 = 6.72
Assay: Inhibition of HCV Con1 genotype 1b NS5B RNA dependent RNA polymerase P495L mutant-mediated incorporation of radiolabeled nucleotides by scintillation proximity assay
Drug: cytisine
Target: Neuronal acetylcholine receptor subunit alpha-7 (Ion channel)
Gene: CHRNA7
UniProt: P36544 (ACHA7_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.85
Assay: Binding affinity to human Nicotinic acetylcholine receptor alpha7 expressed in IMR32 cells using [3H]alpha-bungarotoxin
Drug: cytisine
Target: Acetylcholine receptor subunit delta (Ion channel)
Gene: chrnd
UniProt: P02718 (ACHD_TORCA)
Organism: Torpedo californica
Activity: EC50 = 4
Assay: Compound was evaluated for functional potencies and efficacies at human Nicotinic acetylcholine receptor subtype TE671 (muscle)
Drug: cytisine
Target: Neuronal acetylcholine receptor subunit alpha-4 (Ion channel)
Gene: Chrna4
UniProt: P09483 (ACHA4_RAT)
Organism: Rattus norvegicus
Activity: Ki = 9.47
Assay: Displacement of [3H]cytisine from alpha4beta2 nicotinic acetylcholine receptor in rat brain cortex membrane homogenates
Drug: cytisine
Target: Neuronal acetylcholine receptor subunit alpha-7 (Ion channel)
Gene: Chrna7
UniProt: Q05941 (ACHA7_RAT)
Organism: Rattus norvegicus
Activity: Ki = 9.05
Assay: In vitro binding affinity towards Nicotinic acetylcholine receptor alpha7 using [125I]-alpha-Bungarotoxin in rat brain
Drug: cytisine
Target: Acetylcholine receptor subunit alpha (Ion channel)
Gene: CHRNA1
UniProt: P02710 (ACHA_TORCA)
Organism: Torpedo californica
Activity: IC50 = 5.45
Assay: Displacement of [3H]alpha-BGT from nAChR in Torpedo nobiliana electric organs membranes by scintillation counting method
Drug: cytisine
Target: Nicotinic acetylcholine receptor alpha 5 subunit (Ion channel)
Gene: nAChRalpha5
UniProt: A9XFY4 (A9XFY4_MUSDO)
Organism: Musca domestica
Activity: Ki = 5.91
Assay: Displacement of [3H]alpha-bungarotoxin from nAChR in Musca domestica (house fly) head membrane after 60 min by scintillation counting