AIM-Harvard/TrialPanorama-filtered huggingface dataset:
Drug: sulbactam
Target: Beta-lactamase TEM (Enzyme)
Gene: bla
UniProt: P62594 (BLAT_SALTI)
Organism: Salmonella typhi
Activity: Ki = 6.1
Drug: sulbactam
Target: ADC-18 protein (Enzyme)
Gene: adc-18
UniProt: Q0VTS0 (Q0VTS0_ACIPI)
Organism: Acinetobacter pittii
Activity: IC50 = 4.93
Assay: Inhibition of Acinetobacter genomosp. 3 isolate 195 ADC-18
Drug: sulbactam
Target: Beta-lactamase 1 (Enzyme)
Gene: blaY
UniProt: P00809 (BLAC_BACCE)
Organism: Bacillus cereus
Activity: IC50 = 4.6
Assay: Inhibition of Beta-lactamase of Bacillus cereus (class A enzyme) without pre-incubation
Drug: sulbactam
Target: Beta-lactamase (Enzyme)
UniProt: D2SSQ3 (D2SSQ3_PSEAI)
Organism: Pseudomonas aeruginosa
Activity: IC50 = 5.52
Assay: Inhibition of Pseudomonas aeruginosa 531 beta-lactamase BEL-2
Drug: sulbactam
Target: Beta-lactamase (Enzyme)
Gene: bla(BEL1)
UniProt: Q3SAW3 (Q3SAW3_PSEAI)
Organism: Pseudomonas aeruginosa
Activity: IC50 = 5.52
Assay: Inhibition of Pseudomonas aeruginosa 51170 beta-lactamase BEL-1
Drug: sulconazole
Target: Alpha-2A adrenergic receptor (GPCR)
Gene: ADRA2A
UniProt: P08913 (ADA2A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.819
Assay: DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)
Drug: sulconazole
Target: Cytochrome P450 3A4 (Enzyme)
Gene: CYP3A4
UniProt: P08684 (CP3A4_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7.155
Assay: DRUGMATRIX: CYP450, 3A4 enzyme inhibition (substrate: 7-Benzyloxy-4-(trifluoromethyl)-coumarin)
Drug: sulconazole
Target: Sodium-dependent serotonin transporter (Transporter)
Gene: SLC6A4
UniProt: P31645 (SC6A4_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.125
Assay: DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine)
Drug: sulconazole
Target: Sodium-dependent noradrenaline transporter (Transporter)
Gene: SLC6A2
UniProt: P23975 (SC6A2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.697
Assay: DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55)
Drug: sulconazole
Target: 5-hydroxytryptamine receptor 2A (GPCR)
Gene: HTR2A
UniProt: P28223 (5HT2A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.95
Assay: DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin)
Drug: sulconazole
Target: 5-hydroxytryptamine receptor 2B (GPCR)
Gene: HTR2B
UniProt: P41595 (5HT2B_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.716
Assay: DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
Drug: sulconazole
Target: 5-hydroxytryptamine receptor 2C (GPCR)
Gene: HTR2C
UniProt: P28335 (5HT2C_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.836
Assay: DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine)
Drug: sulconazole
Target: Alpha-2B adrenergic receptor (GPCR)
Gene: ADRA2B
UniProt: P18089 (ADA2B_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.786
Assay: DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
Drug: sulconazole
Target: D(3) dopamine receptor (GPCR)
Gene: DRD3
UniProt: P35462 (DRD3_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.977
Assay: DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone)
Drug: sulconazole
Target: Muscarinic acetylcholine receptor M1 (GPCR)
Gene: CHRM1
UniProt: P11229 (ACM1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.053
Assay: DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine)
Drug: sulconazole
Target: Muscarinic acetylcholine receptor M3 (GPCR)
Gene: CHRM3
UniProt: P20309 (ACM3_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.142
Assay: DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)
Drug: sulconazole
Target: Muscarinic acetylcholine receptor M4 (GPCR)
Gene: CHRM4
UniProt: P08173 (ACM4_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.258
Assay: DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine)
Drug: sulconazole
Target: Muscarinic acetylcholine receptor M5 (GPCR)
Gene: CHRM5
UniProt: P08912 (ACM5_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.727
Assay: DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
Drug: sulconazole
Target: Alpha-2C adrenergic receptor (GPCR)
Gene: ADRA2C
UniProt: P18825 (ADA2C_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.144
Assay: DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
Drug: sulconazole
Target: Sodium-dependent dopamine transporter (Transporter)
Gene: SLC6A3
UniProt: Q01959 (SC6A3_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.863
Assay: DRUGMATRIX: Dopamine Transporter radioligand binding (ligand: [125I] RTI-55)
Drug: sulconazole
Target: Cytochrome P450 2D6 (Enzyme)
Gene: CYP2D6
UniProt: P10635 (CP2D6_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.097
Assay: DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)
Drug: sulconazole
Target: Adenosine receptor A3 (GPCR)
Gene: ADORA3
UniProt: P0DMS8 (AA3R_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.828
Assay: DRUGMATRIX: Adenosine A3 radioligand binding (ligand: AB-MECA)
Drug: sulconazole
Target: Lanosterol 14-alpha demethylase (Enzyme)
Gene: ERG11
UniProt: P10613 (CP51_CANAL)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876)
Action type: INHIBITOR
Assay: Mechanism of Action; CHEMBL1780; SINGLE PROTEIN
Drug: sulconazole
Target: Beta-lactamase (Enzyme)
Gene: ampC
UniProt: P00811 (AMPC_ECOLI)
Organism: Escherichia coli (strain K12)
Activity: IC50 = 4.85
Assay: Compound was tested for the inhibition of beta-lactamase
Drug: sulconazole
Target: Cytochrome P450 2C9 (Enzyme)
Gene: CYP2C9
UniProt: P11712 (CP2C9_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.699
Assay: DRUGMATRIX: CYP450, 2C9 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)
Drug: sulconazole
Target: Cytochrome P450 1A2 (Enzyme)
Gene: CYP1A2
UniProt: P05177 (CP1A2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.222
Assay: DRUGMATRIX: CYP450, 1A2 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)
Drug: sulconazole
Target: Cytochrome P450 2C19 (Enzyme)
Gene: CYP2C19
UniProt: P33261 (CP2CJ_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7.796
Assay: DRUGMATRIX: CYP450, 2C19 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)
Drug: sulconazole
Target: Alkaline phosphatase, tissue-nonspecific isozyme (Enzyme)
Gene: ALPL
UniProt: P05186 (PPBT_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 4.22
Assay: PUBCHEM_BIOASSAY: uHTS identification of compounds activating TNAP in the absence of phosphate acceptor performed in luminescent assay. (Class of assay: confirmatory) [Related pubchem assays: 813, 518, 1548, 1450 ]
Drug: sulconazole
Target: Tyrosine-protein kinase Fyn (Kinase)
Gene: FYN
UniProt: P06241 (FYN_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.431
Assay: DRUGMATRIX: Protein Tyrosine Kinase, Fyn enzyme inhibition (substrate: Poly(Glu:Tyr))
Drug: sulconazole
Target: Thromboxane-A synthase (Enzyme)
Gene: TBXAS1
UniProt: P24557 (THAS_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.738
Assay: DRUGMATRIX: Thromboxane Synthetase enzyme inhibition (substrate: PGH2)
Drug: sulconazole
Target: Bile acid receptor (Nuclear hormone receptor)
Gene: NR1H4
UniProt: Q96RI1 (NR1H4_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.16
Assay: Antagonist activity at human GTS-tagged FXR after 20 mins by TR-FRET assay
Drug: sulconazole
Target: Indoleamine 2,3-dioxygenase 1 (Enzyme)
Gene: IDO1
UniProt: P14902 (I23O1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.19
Drug: sulconazole
Target: Substance-K receptor (GPCR)
Gene: TACR2
UniProt: P21452 (NK2R_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.782
Assay: DRUGMATRIX: Tachykinin NK2  radioligand binding (ligand: [3H] SR-48968)
Drug: sulconazole
Target: Indoleamine 2,3-dioxygenase 2 (Enzyme)
Gene: Ido2
UniProt: Q8R0V5 (I23O2_MOUSE)
Organism: Mus musculus
Activity: IC50 = 5
Assay: Inhibition of mouse Ido2 transfected in HEK293T cells using L-tryptophan as substrate assessed as kynurenine formation after 45 mins by spectrophotometric analysis
Drug: sulconazole
Target: Malate dehydrogenase cytoplasmic  (Enzyme)
Gene: MDH1
UniProt: P40925 (MDHC_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.7
Assay: Inhibition of malate dehydrogenase (MDH)
Drug: sulconazole
Target: Indoleamine 2,3-dioxygenase 1 (Enzyme)
Gene: Ido1
UniProt: P28776 (I23O1_MOUSE)
Organism: Mus musculus
Activity: IC50 = 4.53
Assay: Inhibition of mouse Ido1 transfected in HEK293T cells using L-tryptophan as substrate assessed as kynurenine formation after 45 mins by spectrophotometric analysis
Drug: sulfacetamide
Target: Dihydrofolate reductase (Enzyme)
Gene: DHFR
UniProt: P00374 (DYR_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.74
Assay: Inhibition of human DHFR after 2 mins
Drug: sulfacetamide
Target: Dihydropteroate synthase (Enzyme)
Gene: folP
UniProt: P0AC13 (DHPS_ECOLI)
Organism: Escherichia coli (strain K12)
Action type: INHIBITOR
Assay: Mechanism of Action; CHEMBL2364668; SINGLE PROTEIN
Drug: sulfacetamide
Target: Dihydrofolate reductase (Enzyme)
Gene: DHFR
UniProt: P00376 (DYR_BOVIN)
Organism: Bos taurus
Activity: IC50 = 4.66
Assay: Inhibition of bovine DHFR after 2 mins
Drug: sulfacytine
Target: 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase-dihydropteroate synthase; Dihydropteroate synthetase (Kinase)
Gene: PPPK-DHPS
UniProt: Q25704 (Q25704_PLAFA)
Organism: Plasmodium falciparum
Action type: INHIBITOR
Assay: Mechanism of Action; CHEMBL2013; SINGLE PROTEIN
Drug: sulfadiazine
Target: 5-hydroxytryptamine receptor 2A (GPCR)
Gene: HTR2A
UniProt: P28223 (5HT2A_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.03
Drug: sulfadiazine
Target: 5-hydroxytryptamine receptor 2B (GPCR)
Gene: HTR2B
UniProt: P41595 (5HT2B_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.96
Drug: sulfadiazine
Target: Dihydroorotate dehydrogenase (quinone), mitochondrial (Enzyme)
UniProt: Q08210 (PYRD_PLAF7)
Organism: Plasmodium falciparum (isolate 3D7)
Drug: sulfadiazine
Target: Dihydropteroate synthase (Enzyme)
Gene: folP
UniProt: P0AC13 (DHPS_ECOLI)
Organism: Escherichia coli (strain K12)
Action type: INHIBITOR
Assay: Mechanism of Action; CHEMBL2364668; SINGLE PROTEIN
Drug: sulfadiazine
Target: Aurora kinase A (Kinase)
Gene: AURKA
UniProt: O14965 (AURKA_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.68
Assay: Inhibition of aurora kinase A
Drug: sulfadiazine
Target: High affinity choline transporter 1 (Transporter)
Gene: SLC5A7
UniProt: Q9GZV3 (SC5A7_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.24
Drug: sulfadimethoxine
Target: 5-hydroxytryptamine receptor 6 (GPCR)
Gene: HTR6
UniProt: P50406 (5HT6R_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.206
Assay: DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT6 radioligand binding (ligand: [3H] Lysergic acid diethylamide)
Drug: sulfadimidine
Target: Dihydropteroate synthase (Enzyme)
Gene: folP
UniProt: P0AC13 (DHPS_ECOLI)
Organism: Escherichia coli (strain K12)
Action type: INHIBITOR
Assay: Mechanism of Action; CHEMBL2364668; SINGLE PROTEIN
Drug: sulfadimidine
Target: Lactoylglutathione lyase (Enzyme)
Gene: GLO1
UniProt: Q04760 (LGUL_HUMAN)
Organism: Homo sapiens
Drug: sulfadoxine
Target: 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase-dihydropteroate synthase; Dihydropteroate synthetase (Kinase)
Gene: PPPK-DHPS
UniProt: Q25704 (Q25704_PLAFA)
Organism: Plasmodium falciparum
Action type: INHIBITOR
Assay: Mechanism of Action; CHEMBL2013; SINGLE PROTEIN
Drug: sulfadoxine
Target: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase (Unclassified)
Gene: PF3D7_0810800
UniProt: Q8IAU3 (Q8IAU3_PLAF7)
Organism: Plasmodium falciparum (isolate 3D7)
Activity: IC50 = 7.14
Assay: Parasite growth inhibition assay
Drug: sulfaethidole
Target: RAC-alpha serine/threonine-protein kinase (Kinase)
Gene: AKT1
UniProt: P31749 (AKT1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.11
Assay: SPR Competitive Binding Assay: SPR interaction analyses were performed with a Biacore 2000, using Biacore 2000 Control Software v3.2 and BIAevaluation v4.1 analysis software (Biacore) as described in Mol Cancer Ther 7:2621 (2008). For the competitive binding assays and the Ki determination, PtdIns(3,4,5)phosphate-biotin labeled liposomes (Echelon Biosciences) and SA chips were used with increasing concentrations of the compound tested.
Drug: sulfaguanidine
Target: Prothrombin (Enzyme)
Gene: F2
UniProt: P00734 (THRB_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.02
Assay: Inhibitory activity against human thrombin (using Chromozym TH as the substrate)
Drug: sulfaguanidine
Target: Trypsin (Enzyme)
Gene: PRSS1|PRSS2|PRSS3
UniProt: P07477|P07478|P35030 (TRY1_HUMAN|TRY2_HUMAN|TRY3_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.87
Assay: Inhibitory activity against human trypsin (using Chromozym TH as the substrate)
Drug: sulfamerazine
Target: Dihydropteroate synthase (Enzyme)
Gene: folP
UniProt: P0AC13 (DHPS_ECOLI)
Organism: Escherichia coli (strain K12)
Action type: INHIBITOR
Assay: Mechanism of Action; CHEMBL2364668; SINGLE PROTEIN
Drug: sulfameter
Target: Dihydropteroate synthase (Enzyme)
Gene: folP
UniProt: P0AC13 (DHPS_ECOLI)
Organism: Escherichia coli (strain K12)
Action type: INHIBITOR
Assay: Mechanism of Action; CHEMBL2364668; SINGLE PROTEIN
Drug: sulfamethizole
Target: Dihydropteroate synthase (Enzyme)
Gene: folP
UniProt: P0AC13 (DHPS_ECOLI)
Organism: Escherichia coli (strain K12)
Action type: INHIBITOR
Drug: sulfamethoxazole
Target: Bifunctional protein FolC (Enzyme)
Gene: folC
UniProt: P08192 (FOLC_ECOLI)
Organism: Escherichia coli (strain K12)
Drug: sulfamethoxazole
Target: Dihydropteroate synthase (Enzyme)
Gene: folP
UniProt: P0AC13 (DHPS_ECOLI)
Organism: Escherichia coli (strain K12)
Activity: IC50 = 5.33
Action type: INHIBITOR
Assay: In vitro inhibition of dihydropteroate synthase from Escherichia coli.
Drug: sulfamethoxazole
Target: Dihydrofolate reductase (Enzyme)
UniProt: P16184 (DYR_PNECA)
Organism: Pneumocystis carinii
Activity: IC50 = 7
Assay: Inhibitory activity against dihydrofolate reductase in Pneumocystis carinii in the prence of 100 micro M PABA.
Drug: sulfamethoxazole
Target: Pol polyprotein (Enzyme)
Gene: pol
UniProt: Q72874 (Q72874_9HIV1)
Organism: Human immunodeficiency virus 1
Activity: Ki = 8
Assay: Inhibition constant for human immunodeficiency virus type 1 protease
Drug: sulfamethoxazole
Target: Endothelin-1 receptor (GPCR)
Gene: Ednra
UniProt: P26684 (EDNRA_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 5.4
Assay: Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
Drug: sulfalene
Target: Dihydropteroate synthase (Enzyme)
Gene: folP
UniProt: P0AC13 (DHPS_ECOLI)
Organism: Escherichia coli (strain K12)
Action type: INHIBITOR
Assay: Mechanism of Action; CHEMBL2364668; SINGLE PROTEIN
Drug: sulfanilamide
Target: Carbonic anhydrase 2 (Enzyme)
Gene: CA2
UniProt: P00918 (CAH2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.62
Assay: Ki value against human carbonic anhydrase II
Drug: sulfanilamide
Target: Carbonic anhydrase 1 (Enzyme)
Gene: CA1
UniProt: P00915 (CAH1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.52
Assay: Inhibition of human carbonic anhydrase 1-catalyzed CO2 hydration preincubated for 10 mins by stopped-flow assay
Drug: sulfanilamide
Target: Carbonic anhydrase 4 (Enzyme)
Gene: CA4
UniProt: P22748 (CAH4_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.52
Assay: Inhibition of cloned isozyme, human carbonic anhydrase IV
Drug: sulfanilamide
Target: Carbonic anhydrase 9 (Enzyme)
Gene: CA9
UniProt: Q16790 (CAH9_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.62
Assay: Inhibition of catalytic domain of human recombinant CA IX
Drug: sulfanilamide
Target: Carbonic anhydrase 12 (Enzyme)
Gene: CA12
UniProt: O43570 (CAH12_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.43
Assay: Inhibitory constant against catalytic domain of human carbonic anhydrase XII
Drug: sulfanilamide
Target: Dihydropteroate synthase (Enzyme)
Gene: folP
UniProt: P0AC13 (DHPS_ECOLI)
Organism: Escherichia coli (strain K12)
Action type: INHIBITOR
Assay: Mechanism of Action; CHEMBL2364668; SINGLE PROTEIN
Drug: sulfanilamide
Target: Carbonic anhydrase 5A, mitochondrial (Enzyme)
Gene: CA5A
UniProt: P35218 (CAH5A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 4.49
Assay: Inhibitory activity against human recombinant mitochondrial isozyme CA VA
Drug: sulfanilamide
Target: Carbonic anhydrase 5B, mitochondrial (Enzyme)
Gene: CA5B
UniProt: Q9Y2D0 (CAH5B_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.44
Assay: Inhibitory activity against human recombinant mitochondrial isozyme CA VB
Drug: sulfanilamide
Target: Carbonic anhydrase 7 (Enzyme)
Gene: CA7
UniProt: P43166 (CAH7_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.15
Assay: Ki value against human carbonic anhydrase VII
Drug: sulfanilamide
Target: Carbonic anhydrase (Enzyme)
Gene: cynT
UniProt: O24855 (CYNT_HELPY)
Organism: Helicobacter pylori (strain ATCC 700392 / 26695)
Activity: Ki = 6.37
Assay: Inhibition of Helicobacter pylori recombinant CA
Drug: sulfanilamide
Target: Carbonic anhydrase 3 (Enzyme)
Gene: CA3
UniProt: P07451 (CAH3_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.01
Assay: Inhibition of human recombinant CA3 by stopped flow CO2 hydrase assay
Drug: sulfanilamide
Target: Carbonic anhydrase 6 (Enzyme)
Gene: CA6
UniProt: P23280 (CAH6_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.03
Assay: Inhibition of full length human recombinant CA VI
Drug: sulfanilamide
Target: Carbonic anhydrase 14 (Enzyme)
Gene: CA14
UniProt: Q9ULX7 (CAH14_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.27
Assay: Inhibitory constant against human carbonic anhydrase XIV in CO2 hydrase assay
Drug: sulfanilamide
Target: Carbonic anhydrase 13 (Enzyme)
Gene: Ca13
UniProt: Q9D6N1 (CAH13_MOUSE)
Organism: Mus musculus
Activity: Ki = 7.49
Assay: Inhibitory activity against murine carbonic anhydrase XIII (mCA XIII) by using CO2 hydrase assay method
Drug: sulfanilamide
Target: Carbonic anhydrase 4 (Enzyme)
Gene: CA4
UniProt: Q95323 (CAH4_BOVIN)
Organism: Bos taurus
Activity: Ki = 5.52
Assay: Inhibition constant against bovine Carbonic anhydrase IV, isolated from lung microsomes
Drug: sulfanilamide
Target: Carbonic anhydrase (Enzyme)
UniProt: P40881 (CAH_METTE)
Organism: Methanosarcina thermophila
Activity: Ki = 6.6
Assay: Inhibitory activity against alpha carbonic anhydrase (Zn-Cam) from Methanosarcina thermophila
Drug: sulfanilamide
Target: Carbonic anhydrase (Enzyme)
UniProt: Q50565 (Q50565_METTH)
Organism: Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)
Activity: Ki = 4.24
Assay: Inhibitory activity against beta carbonic anhydrase (Cab) from Methanobacterium thermoautotrophicum
Drug: sulfanilamide
Target: Carbonic anhydrase 13 (Enzyme)
Gene: CA13
UniProt: Q8N1Q1 (CAH13_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.49
Assay: Inhibition of human recombinant CA13 by stopped flow CO2 hydrase assay
Drug: sulfanilamide
Target: Carbonic anhydrase 15 (Enzyme)
Gene: Ca15
UniProt: Q99N23 (CAH15_MOUSE)
Organism: Mus musculus
Activity: Ki = 5.02
Assay: Inhibition of mouse recombinant carbonic anhydrase 15 by stopped flow CO2 hydrase assay
Drug: sulfanilamide
Target: Carbonic anhydrase (Enzyme)
Gene: NCE103
UniProt: P53615 (CAN_YEAST)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Activity: Ki = 4.73
Assay: Inhibition of Saccharomyces cerevisiae recombinant CA expressed in Escherichia coli by stopped-flow CO2 hydrase assay
Drug: sulfanilamide
Target: Carbonic anhydrase (Enzyme)
Gene: NCE103
UniProt: Q5AJ71 (CAN_CANAL)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876)
Activity: Ki = 6.62
Assay: Inhibition of Helicobacter pylori beta-carbonic anhydrase by stopped-flow CO2 hydration assay
Drug: sulfanilamide
Target: Probable transmembrane carbonic anhydrase (Carbonate dehydratase) (Carbonic dehydratase); Transmembrane carbonic anhydrase (Enzyme)
UniProt: P96878 (P96878_MYCTU)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Activity: Ki = 5.2
Assay: Inhibition of Mycobacterium tuberculosis recombinant beta-carbonic anhydrase Rv3273 preincubated for 15 mins by stopped-flow CO2 hydrase assay
Drug: sulfanilamide
Target: Carbonic anhydrase (Enzyme)
UniProt: Q6FTL6 (Q6FTL6_CANGA)
Organism: Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)
Activity: Ki = 5.1
Assay: Inhibition of recombinant full length Candida glabrata NCE103 expressed in Escherichia coli BL21 preincubated for 15 mins by stopped-flow CO2 hydrase assay
Drug: sulfanilamide
Target: Alpha carbonic anhydrase (Enzyme)
Gene: CA
UniProt: B5SU02 (B5SU02_9CNID)
Organism: Stylophora pistillata
Activity: Ki = 6.44
Assay: Inhibition of cloned Stylophora pistillata alpha-CA expressed in human HEK293 cells by stopped-flow CO2 assay
Drug: sulfanilamide
Target: Carbonic anhydrase (Enzyme)
Gene: CA2
UniProt: C0IX24 (C0IX24_9CNID)
Organism: Stylophora pistillata
Activity: Ki = 6.52
Assay: Inhibition of Stylophora pistillata carbonic anhydrase 2 by stopped-flow CO2 hydration assay
Drug: sulfanilamide
Target: Carbonic anhydrase 2 (Enzyme)
Gene: CAN2
UniProt: Q3I4V7 (Q3I4V7_CRYNV)
Organism: Cryptococcus neoformans var. grubii
Activity: Ki = 6.11
Assay: Inhibition of Cryptococcus neoformans recombinant Can2 beta-carbonic anhydrase after 15 mins by stopped flow CO2 hydration assay
Drug: sulfanilamide
Target: Astrosclerin-3 (Enzyme)
UniProt: A6YCJ1 (A6YCJ1_9METZ)
Organism: Astrosclera willeyana
Activity: Ki = 5.11
Assay: Inhibition of GST-tagged astrosclera willeyana Astrosclerin-3 expressed in Escherichia coli after 15 mins preincubation by stopped flow CO2 hydration assay
Drug: sulfanilamide
Target: Beta-carbonic anhydrase 1 (Enzyme)
Gene: mtcA1
UniProt: P9WPJ7 (MTCA1_MYCTU)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Activity: Ki = 5.03
Assay: Inhibition of Mycobacterium tuberculosis recombinant beta-carbonic anhydrase Rv1284 preincubated for 15 mins by stopped-flow CO2 hydrase assay
Drug: sulfanilamide
Target: Delta carbonic anhydrase (Unclassified)
Gene: ca1
UniProt: Q5U9J1 (Q5U9J1_THAWE)
Organism: Thalassiosira weissflogii
Activity: Ki = 6.74
Assay: Inhibition of Thalassiosira weissflogii delta carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration assay
Drug: sulfanilamide
Target: Carbonic anhydrase 2 (Enzyme)
Gene: mtcA2
UniProt: P9WPJ9 (MTCA2_MYCTU)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Activity: Ki = 4.53
Assay: Inhibition of full length Mycobacterium tuberculosis H37Rv recombinant carbonic anhydrase 2 encoded by RV3588c by stopped flow CO2 hydration assay
Drug: sulfanilamide
Target: Carbonic anhydrase 2 (Enzyme)
Gene: CA2
UniProt: P00921 (CAH2_BOVIN)
Organism: Bos taurus
Activity: Ki = 6.07
Assay: Binding affinity to bovine carbonic anhydrase 2
Drug: sulfanilamide
Target: Carbonic anhydrase (Enzyme)
UniProt: Q5TU56 (Q5TU56_ANOGA)
Organism: Anopheles gambiae
Activity: Ki = 6.06
Drug: sulfanilamide
Target: Carbonic anhydrase, alpha family (Unclassified)
UniProt: Q31FD6 (Q31FD6_HYDCU)
Organism: Hydrogenovibrio crunogenus (strain XCL-2)
Activity: Ki = 6.2
Assay: Inhibition of recombinant Thiomicrospira crunogena XCL-2 carbonic anhydrase by stopped flow CO2 hydrase assay
Drug: sulfanilamide
Target: Carbonate dehydratase (Enzyme)
UniProt: B2V8E3 (B2V8E3_SULSY)
Organism: Sulfurihydrogenibium sp. (strain YO3AOP1)
Activity: Ki = 6.19
Assay: Inhibition of recombinant Sulfurihydrogenibium yellowstonense YO3AOP1 carbonic anhydrase by stopped flow CO2 hydrase assay
Drug: sulfaphenazole
Target: Cytochrome P450 2C9 (Enzyme)
Gene: CYP2C9
UniProt: P11712 (CP2C9_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.699
Assay: DRUGMATRIX: CYP450, 2C9 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)
Drug: sulfaphenazole
Target: Dihydropteroate synthase (Enzyme)
Gene: folP
UniProt: P0AC13 (DHPS_ECOLI)
Organism: Escherichia coli (strain K12)
Action type: INHIBITOR
Assay: Mechanism of Action; CHEMBL2364668; SINGLE PROTEIN
Drug: sulfapyridine
Target: Dihydropteroate synthase (Enzyme)
Gene: folP
UniProt: P0AC13 (DHPS_ECOLI)
Organism: Escherichia coli (strain K12)
Action type: INHIBITOR
Assay: Mechanism of Action; CHEMBL2364668; SINGLE PROTEIN
Drug: sulfapyridine
Target: Dihydropteroate synthase type-1 (Enzyme)
Gene: sulI
UniProt: Q49184 (DHP1_MYCFO)
Organism: Mycobacterium fortuitum