AIM-Harvard/TrialPanorama-filtered huggingface dataset:
Drug: silymarin
Target: Carbonic anhydrase 9 (Enzyme)
Gene: CA9
UniProt: Q16790 (CAH9_HUMAN)
Organism: Homo sapiens
Activity: Ki = 4.99
Assay: Inhibition of human carbonic anhydrase 9 after 15 mins by stopped flow CO2 hydration method
Drug: silymarin
Target: Carbonic anhydrase 12 (Enzyme)
Gene: CA12
UniProt: O43570 (CAH12_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.04
Assay: Inhibition of human carbonic anhydrase 12 after 15 mins by stopped flow CO2 hydration method
Drug: silymarin
Target: Prothrombin (Enzyme)
Gene: F2
UniProt: P00734 (THRB_HUMAN)
Organism: Homo sapiens
Activity: Kd = 4.73
Assay: Inhibition of human thrombin assessed as equilibrium dissociation constant at 50 to 1000 uM by BIAcore analysis
Drug: silymarin
Target: Carbonic anhydrase 5A, mitochondrial (Enzyme)
Gene: CA5A
UniProt: P35218 (CAH5A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.39
Assay: Inhibition of human carbonic anhydrase 5a after 15 mins by stopped flow CO2 hydration method
Drug: silymarin
Target: Carbonic anhydrase 5B, mitochondrial (Enzyme)
Gene: CA5B
UniProt: Q9Y2D0 (CAH5B_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.34
Assay: Inhibition of human carbonic anhydrase 5b after 15 mins by stopped flow CO2 hydration method
Drug: silymarin
Target: Carbonic anhydrase 7 (Enzyme)
Gene: CA7
UniProt: P43166 (CAH7_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.33
Assay: Inhibition of human carbonic anhydrase 7 after 15 mins by stopped flow CO2 hydration method
Drug: silymarin
Target: Carbonic anhydrase 3 (Enzyme)
Gene: CA3
UniProt: P07451 (CAH3_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.19
Assay: Inhibition of human carbonic anhydrase 3 after 15 mins by stopped flow CO2 hydration method
Drug: silymarin
Target: Carbonic anhydrase 6 (Enzyme)
Gene: CA6
UniProt: P23280 (CAH6_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.01
Assay: Inhibition of human carbonic anhydrase 6 after 15 mins by stopped flow CO2 hydration method
Drug: silymarin
Target: Carbonic anhydrase 14 (Enzyme)
Gene: CA14
UniProt: Q9ULX7 (CAH14_HUMAN)
Organism: Homo sapiens
Activity: Ki = 4.93
Assay: Inhibition of human carbonic anhydrase 14 after 15 mins by stopped flow CO2 hydration method
Drug: silymarin
Target: Polyphenol oxidase 2 (Enzyme)
Gene: PPO2
UniProt: O42713 (PPO2_AGABI)
Organism: Agaricus bisporus
Activity: Ki = 6.16
Assay: Inhibition of monophenolase activity of mushroom tyrosinase assessed as inhibition constant for free enzyme-inhibitor complex by measuring reduction in dopachrome formation using L-Tyrosine substrate by UV-Vis spectrophotometry
Drug: silymarin
Target: Carbonic anhydrase 13 (Enzyme)
Gene: CA13
UniProt: Q8N1Q1 (CAH13_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.32
Assay: Inhibition of human carbonic anhydrase 13 after 15 mins by stopped flow CO2 hydration method
Drug: silymarin
Target: Carbonic anhydrase 15 (Enzyme)
Gene: Ca15
UniProt: Q99N23 (CAH15_MOUSE)
Organism: Mus musculus
Activity: Ki = 6.19
Assay: Inhibition of mouse carbonic anhydrase 15 after 15 mins by stopped flow CO2 hydration method
Drug: silymarin
Target: Xanthine dehydrogenase/oxidase (Enzyme)
Gene: Xdh
UniProt: P22985 (XDH_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 4.1
Assay: Inhibition of rat liver xanthine oxidase after 2 hrs by spectrophotometry
Drug: silymarin
Target: P-glycoprotein 3 (Transporter)
Gene: Abcb1a
UniProt: P21447 (MDR1A_MOUSE)
Organism: Mus musculus
Activity: Kd = 5.17
Assay: Compound was tested for the binding affinity towards recombinant NBD2 C-terminal cytotoxic nucleotide-binding domain of mouse P-Glycoprotein
Drug: silymarin
Target: Solute carrier family 2, facilitated glucose transporter member 4 (Transporter)
Gene: Slc2a4
UniProt: P14142 (GLUT4_MOUSE)
Organism: Mus musculus
Activity: Ki = 4.22
Assay: Competitive inhibition of GLUT4 in mouse 3T3L1 cells assessed as reduction in insulin-stimulated [3H]-2-deoxy-D-glucose uptake preincubated for 20 mins followed by measured for [3H]-2-deoxy-D-glucose addition measured after 1 to 10 mins by Lineweaver-Burk plot analysis
Drug: simvastatin
Target: Nuclear receptor subfamily 1 group I member 3 (Nuclear hormone receptor)
Gene: NR1I3
UniProt: Q14994 (NR1I3_HUMAN)
Organism: Homo sapiens
Drug: simvastatin
Target: 3-hydroxy-3-methylglutaryl-coenzyme A reductase (Enzyme)
Gene: HMGCR
UniProt: P04035 (HMDH_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7.77
Action type: INHIBITOR
Drug: simvastatin
Target: Acetylcholinesterase (Enzyme)
Gene: ache
UniProt: O42275 (ACES_ELEEL)
Organism: Electrophorus electricus
Activity: Ki = 5.74
Assay: Inhibition of Electrophorus electricus (electric eel) acetylcholinesterase (AChE) assessed as inhibition of ATCh hydrolysis by Ellman method
Drug: simvastatin
Target: 3-hydroxy-3-methylglutaryl-coenzyme A reductase (Enzyme)
Gene: Hmgcr
UniProt: P51639 (HMDH_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 8.37
Assay: Inhibition of HMGR in rat hepatic microsomes assessed as conversion of [14C]HMG-CoA to [14C]mevalonic acid
Drug: simvastatin
Target: Cholinesterase (Enzyme)
Gene: BCHE
UniProt: P81908 (CHLE_HORSE)
Organism: Equus caballus
Activity: Ki = 6.12
Assay: Inhibition of Equus caballus (horse) serum butyrylcholinesterase (BChE) assessed as inhibition of BTCh hydrolysis by Ellman method
Drug: simvastatin
Target: 3-hydroxy-3-methylglutaryl-coenzyme A reductase (Enzyme)
Gene: hmg1
UniProt: Q10283 (HMDH_SCHPO)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Activity: IC50 = 4.02
Assay: Inhibition of Schizosaccharomyces pombe HMG-CoA reductase by spectrophotometry
Drug: sirolimus
Target: Sodium/nucleoside cotransporter 1 (Transporter)
Gene: SLC28A1
UniProt: O00337 (S28A1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.431
Assay: DRUGMATRIX: Sodium/nucleoside co-transporter radioligand binding (ligand: nitrobenzylthioinosine)
Drug: sirolimus
Target: Cytochrome P450 3A4 (Enzyme)
Gene: CYP3A4
UniProt: P08684 (CP3A4_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.699
Assay: DRUGMATRIX: CYP450, 3A4 enzyme inhibition (substrate: 7-Benzyloxy-4-(trifluoromethyl)-coumarin)
Drug: sirolimus
Target: Multidrug resistance protein 1 (Transporter)
Gene: ABCB1
UniProt: P08183 (MDR1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.2
Drug: sirolimus
Target: Peptidyl-prolyl cis-trans isomerase FKBP1A (Enzyme)
Gene: FKBP1A
UniProt: P62942 (FKB1A_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.96
Action type: INHIBITOR
Drug: sirolimus
Target: Cytochrome P450 2C9 (Enzyme)
Gene: CYP2C9
UniProt: P11712 (CP2C9_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.699
Assay: DRUGMATRIX: CYP450, 2C9 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)
Drug: sirolimus
Target: Serine/threonine-protein kinase mTOR (Kinase)
Gene: MTOR
UniProt: P42345 (MTOR_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 10
Assay: Inhibition of mTOR kinase expressed in human HEK293 cells by Western blot analysis
Drug: sirolimus
Target: Peptidyl-prolyl cis-trans isomerase FKBP3 (Enzyme)
Gene: FKBP3
UniProt: Q00688 (FKBP3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 9.7
Drug: sirolimus
Target: Cytochrome P450 2C19 (Enzyme)
Gene: CYP2C19
UniProt: P33261 (CP2CJ_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.398
Assay: DRUGMATRIX: CYP450, 2C19 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)
Drug: sirolimus
Target: Peptidyl-prolyl cis-trans isomerase FKBP1B (Enzyme)
Gene: FKBP1B
UniProt: P68106 (FKB1B_HUMAN)
Organism: Homo sapiens
Activity: Kd = 9.7
Drug: sirolimus
Target: Peptidyl-prolyl cis-trans isomerase FKBP5 (Enzyme)
Gene: FKBP5
UniProt: Q13451 (FKBP5_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.52
Assay: Binding affinity to human FKBP51 by competitive fluorescence polarization assay
Drug: sirolimus
Target: Programmed cell death protein 4 (Nuclear other)
Gene: PDCD4
UniProt: Q53EL6 (PDCD4_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 7.3
Assay: Inhibition of TPA-induced degradation of Pdcd4 (amino acid 39-91) expressed in human HEK293 cells assessed as minimum compound concentration required for 50% recovery of Pdcd4-luciferase signal incubated for 8 hrs by luciferase reporter gene assay
Drug: sirolimus
Target: Eukaryotic translation initiation factor 4E (Nuclear other)
Gene: EIF4E
UniProt: P06730 (IF4E_HUMAN)
Organism: Homo sapiens
Activity: Kd = 9.3
Assay: Binding affinity to purified elF4E
Drug: sirolimus
Target: Peptidyl-prolyl cis-trans isomerase FKBP1A (Enzyme)
Gene: Fkbp1a
UniProt: P26883 (FKB1A_MOUSE)
Organism: Mus musculus
Activity: IC50 = 9
Assay: Inhibition of FKBP12 in mouse T cells assessed as reduction in cell proliferation
Drug: sisomicin
Target: 30S ribosomal protein S12 (Cytosolic other)
Gene: rpsL
UniProt: P0A7S3 (RS12_ECOLI)
Organism: Escherichia coli (strain K12)
Assay: Mechanism of Action for decitabine
Drug: sitagliptin
Target: Dipeptidyl peptidase 4 (Enzyme)
Gene: Dpp4
UniProt: P14740 (DPP4_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 7.48
Assay: Inhibition of Wistar rat plasma DPP4
Drug: sitagliptin
Target: Angiotensin-converting enzyme (Enzyme)
Gene: ACE
UniProt: P12821 (ACE_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.96
Assay: Inhibition of human plasma ACE
Drug: sitagliptin
Target: Dipeptidyl peptidase 4 (Enzyme)
Gene: DPP4
UniProt: P27487 (DPP4_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.774
Action type: INHIBITOR
Drug: sitagliptin
Target: Dipeptidyl peptidase 4 (Enzyme)
Gene: Dpp4
UniProt: P28843 (DPP4_MOUSE)
Organism: Mus musculus
Activity: IC50 = 7.16
Assay: Inhibition of mouse DPP4 at 3 mg/kg
Drug: sitagliptin
Target: Prolyl endopeptidase FAP (Enzyme)
Gene: FAP
UniProt: Q12884 (SEPR_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.23
Drug: sitagliptin
Target: Dipeptidyl peptidase 8 (Enzyme)
Gene: DPP8
UniProt: Q6V1X1 (DPP8_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.96
Assay: Inhibition of human DPP8 expressed in HEK293 cells using Ala-Pro-p-nitroanilide hydrochloride salt as substrate preincubated for 10 mins prior to addition of substrate measured after 30 mins
Drug: sitagliptin
Target: Dipeptidyl peptidase 9 (Enzyme)
Gene: DPP9
UniProt: Q86TI2 (DPP9_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.7
Assay: Inhibition of human DPP9 expressed in HEK293 cells using Ala-Pro-p-nitroanilide hydrochloride salt as substrate preincubated for 10 mins prior to addition of substrate measured after 30 mins
Drug: sitagliptin
Target: Dipeptidyl peptidase 2 (Enzyme)
Gene: DPP7
UniProt: Q9UHL4 (DPP2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.22
Drug: sitagliptin
Target: Dipeptidyl peptidase IV (Unclassified)
Gene: DPP IV
UniProt: O31048 (O31048_PORGN)
Organism: Porphyromonas gingivalis
Activity: IC50 = 4.75
Assay: Inhibition of Porphyromonas gingivalis N-terminal His-tagged DPP4 expressed in Escherichia coli using Gly-Pro-p-nitroanilide as substrate
Drug: sitafloxacin
Target: DNA gyrase subunit B (Enzyme)
Gene: gyrB
UniProt: P0AES7 (GYRB_ECO57)
Organism: Escherichia coli O157:H7
Drug: sitafloxacin
Target: DNA topoisomerase 4 subunit A (Enzyme)
Gene: parC
UniProt: P72525 (PARC_STRPN)
Organism: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Drug: sitosterol
Target: Amine oxidase [flavin-containing] B (Enzyme)
Gene: MAOB
UniProt: P27338 (AOFB_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.56
Assay: Inhibition of human recombinant MAO-B expressed in baculovirus infected BTI insect cells using benzylamine as substrate after 30 mins by spectrophotometric analysis
Drug: sitosterol
Target: Amine oxidase [flavin-containing] A (Enzyme)
Gene: MAOA
UniProt: P21397 (AOFA_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.34
Assay: Competitive inhibition of human recombinant MAO-A expressed in baculovirus infected BTI insect cells using kynuramine as substrate after 20 mins by Lineweaver-Burk plot analysis
Drug: sitosterol
Target: Prothrombin (Enzyme)
Gene: F2
UniProt: P00734 (THRB_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.57
Assay: Uncompetitive inhibition of human thrombin using T1637 as substrate by Michaelis-Menten plot analysis
Drug: sitosterol
Target: Dipeptidyl peptidase 4 (Enzyme)
Gene: DPP4
UniProt: P27487 (DPP4_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.54
Assay: Inhibition of human DPP4 using H-Gly-Pro-AMC peptide substrate assessed as increase in fluorescence for 20 mins by fluorimetric assay
Drug: sitosterol
Target: Nuclear factor NF-kappa-B p105 subunit (Cytosolic other)
Gene: NFKB1
UniProt: P19838 (NFKB1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.6
Assay: Inhibition of NF-KB p50 subunit/DNA interaction after 20 mins by EMSA
Drug: sitosterol
Target: Acetylcholinesterase (Enzyme)
Gene: ache
UniProt: O42275 (ACES_ELEEL)
Organism: Electrophorus electricus
Activity: IC50 = 4.59
Assay: Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by Ellman's method
Drug: sitosterol
Target: Amine oxidase [flavin-containing] A (Enzyme)
Gene: Maoa
UniProt: P21396 (AOFA_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 5.05
Assay: Inhibition of MAO-A in Sprague-Dawley rat brain mitochondrial fraction after 10 mins in presence of [14C]5-hydroxytryptamine by liquid scintillation analysis
Drug: sitosterol
Target: DNA polymerase beta (Enzyme)
Gene: POLB
UniProt: P06746 (DPOLB_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.58
Assay: Inhibition of DNA polymerase beta lyase activity by deoxyribose phosphate excision assay
Drug: sivelestat
Target: Neutrophil elastase (Enzyme)
Gene: ELANE
UniProt: P08246 (ELNE_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.7
Assay: Binding affinity against Elastase.
Drug: sivelestat
Target: Myeloblastin (Enzyme)
Gene: PRTN3
UniProt: P24158 (PRTN3_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.47
Drug: sivelestat
Target: Neutrophil elastase (Enzyme)
Gene: Elane
UniProt: Q3UP87 (ELNE_MOUSE)
Organism: Mus musculus
Activity: IC50 = 6.84
Drug: solifenacin
Target: Muscarinic acetylcholine receptor M1 (GPCR)
Gene: CHRM1
UniProt: P11229 (ACM1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7.2
Assay: Displacement of [3H]NMS from human muscarinic M1 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting
Drug: solifenacin
Target: Muscarinic acetylcholine receptor M2 (GPCR)
Gene: CHRM2
UniProt: P08172 (ACM2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.24
Action type: ANTAGONIST
Assay: Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting
Drug: solifenacin
Target: Muscarinic acetylcholine receptor M3 (GPCR)
Gene: CHRM3
UniProt: P20309 (ACM3_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.88
Action type: ANTAGONIST
Assay: Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting
Drug: solifenacin
Target: Muscarinic acetylcholine receptor M4 (GPCR)
Gene: CHRM4
UniProt: P08173 (ACM4_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.8
Action type: ANTAGONIST
Drug: solifenacin
Target: Muscarinic acetylcholine receptor M5 (GPCR)
Gene: CHRM5
UniProt: P08912 (ACM5_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.2
Action type: ANTAGONIST
Drug: solifenacin
Target: Muscarinic acetylcholine receptor M2 (GPCR)
Gene: Chrm2
UniProt: P10980 (ACM2_RAT)
Organism: Rattus norvegicus
Activity: Ki = 6.92
Assay: Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate
Drug: solifenacin
Target: Muscarinic acetylcholine receptor M1 (GPCR)
Gene: Chrm1
UniProt: P08482 (ACM1_RAT)
Organism: Rattus norvegicus
Activity: Ki = 8
Assay: Binding affinity for rat cortex muscarinic acetylcholine receptor M1 using [3H]pirenzepine
Drug: solifenacin
Target: Muscarinic acetylcholine receptor M3 (GPCR)
Gene: Chrm3
UniProt: P08483 (ACM3_RAT)
Organism: Rattus norvegicus
Activity: Ki = 8
Assay: Binding affinity for rat salivary gland muscarinic acetylcholine receptor M3 using [3H]N-methylscopolamine
Drug: sorafenib
Target: Tyrosine-protein kinase JAK3 (Kinase)
Gene: JAK3
UniProt: P52333 (JAK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.14
Assay: Binding constant for JAK3(JH1domain-catalytic) kinase domain
Drug: sorafenib
Target: 5-hydroxytryptamine receptor 1A (GPCR)
Gene: HTR1A
UniProt: P08908 (5HT1A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.93
Assay: Displacement of [3H]8-OH-DPAT from 5HT1A receptor after 1.5 hrs by scintillation counter
Drug: sorafenib
Target: 5-hydroxytryptamine receptor 2A (GPCR)
Gene: HTR2A
UniProt: P28223 (5HT2A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.71
Assay: Displacement of [3H]Ketanserin from 5HT2A receptor after 1.5 hrs by scintillation counter
Drug: sorafenib
Target: 5-hydroxytryptamine receptor 2B (GPCR)
Gene: HTR2B
UniProt: P41595 (5HT2B_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.25
Assay: Displacement of [3H]LSD from 5HT2B receptor after 1.5 hrs by scintillation counter
Drug: sorafenib
Target: 5-hydroxytryptamine receptor 2C (GPCR)
Gene: HTR2C
UniProt: P28335 (5HT2C_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.38
Assay: Displacement of [3H]LSD from 5HT2C receptor after 1.5 hrs by scintillation counter
Drug: sorafenib
Target: 5-hydroxytryptamine receptor 6 (GPCR)
Gene: HTR6
UniProt: P50406 (5HT6R_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.21
Assay: Displacement of [3H]LSD from 5HT6 receptor after 1.5 hrs by scintillation counter
Drug: sorafenib
Target: 5-hydroxytryptamine receptor 7 (GPCR)
Gene: HTR7
UniProt: P34969 (5HT7R_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.15
Assay: Displacement of [3H]LSD from 5HT7 receptor after 1.5 hrs by scintillation counter
Drug: sorafenib
Target: 5-hydroxytryptamine receptor 5A (GPCR)
Gene: HTR5A
UniProt: P47898 (5HT5A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.48
Assay: Displacement of [3H]LSD from 5HT5A receptor after 1.5 hrs by scintillation counter
Drug: sorafenib
Target: Platelet-derived growth factor receptor beta (Kinase)
Gene: PDGFRB
UniProt: P09619 (PGFRB_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.43
Action type: INHIBITOR
Assay: Binding constant for PDGFRB kinase domain
Drug: sorafenib
Target: Tyrosine-protein kinase ABL1 (Kinase)
Gene: ABL1
UniProt: P00519 (ABL1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.89
Assay: Average Binding Constant for ABL1; NA=Not Active at 10 uM
Drug: sorafenib
Target: Mast/stem cell growth factor receptor Kit (Kinase)
Gene: KIT
UniProt: P10721 (KIT_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.8
Action type: INHIBITOR
Assay: Binding constant for KIT(V559D) kinase domain
Drug: sorafenib
Target: Epidermal growth factor receptor (Kinase)
Gene: EGFR
UniProt: P00533 (EGFR_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 8.53
Assay: Inhibition of EGFR (unknown origin) incubated for 1 hr assessed as luminescence changes using ATP by ADP-Glo Kinase assay
Drug: sorafenib
Target: Carbonic anhydrase 7 (Enzyme)
Gene: CA7
UniProt: P43166 (CAH7_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.09
Assay: Inhibition of recombinant human CA7 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay
Drug: sorafenib
Target: Proto-oncogene tyrosine-protein kinase Src (Kinase)
Gene: SRC
UniProt: P12931 (SRC_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.41
Assay: Inhibition of recombinant c-Src by radioactive phosphotransfer assay in presence of 10 uM ATP
Drug: sorafenib
Target: Tyrosine-protein kinase Lck (Kinase)
Gene: LCK
UniProt: P06239 (LCK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.57
Assay: Binding constant for LCK kinase domain
Drug: sorafenib
Target: Tyrosine-protein kinase Fyn (Kinase)
Gene: FYN
UniProt: P06241 (FYN_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.08
Assay: Binding constant for FYN kinase domain
Drug: sorafenib
Target: Ephrin type-A receptor 2 (Kinase)
Gene: EPHA2
UniProt: P29317 (EPHA2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.7
Assay: Binding constant for EPHA2 kinase domain
Drug: sorafenib
Target: RAF proto-oncogene serine/threonine-protein kinase (Kinase)
Gene: RAF1
UniProt: P04049 (RAF1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.22
Action type: INHIBITOR
Assay: Inhibition of C-RAF
Drug: sorafenib
Target: Serine/threonine-protein kinase B-raf (Kinase)
Gene: BRAF
UniProt: P15056 (BRAF_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.66
Action type: INHIBITOR
Assay: Inhibition of B-Raf
Drug: sorafenib
Target: Receptor-type tyrosine-protein kinase FLT3 (Kinase)
Gene: FLT3
UniProt: P36888 (FLT3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.35
Action type: INHIBITOR
Assay: Binding constant for FLT3(K663Q) kinase domain
Drug: sorafenib
Target: Proto-oncogene tyrosine-protein kinase receptor Ret (Kinase)
Gene: RET
UniProt: P07949 (RET_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.13
Action type: INHIBITOR
Assay: Binding constant for RET(M918T) kinase domain
Drug: sorafenib
Target: Vascular endothelial growth factor receptor 1 (Kinase)
Gene: FLT1
UniProt: P17948 (VGFR1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.51
Action type: INHIBITOR
Assay: Binding constant for FLT1 kinase domain
Drug: sorafenib
Target: Vascular endothelial growth factor receptor 2 (Kinase)
Gene: KDR
UniProt: P35968 (VGFR2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 10.68
Action type: INHIBITOR
Assay: Inhibition of human N-terminal His-tagged non-phosphorylated VEGFR2 after 60 mins by activity based 100 fold dilution assay
Drug: sorafenib
Target: Vascular endothelial growth factor receptor 3 (Kinase)
Gene: FLT4
UniProt: P35916 (VGFR3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.8
Action type: INHIBITOR
Assay: Average Binding Constant for FLT4; NA=Not Active at 10 uM
Drug: sorafenib
Target: Macrophage colony-stimulating factor 1 receptor (Kinase)
Gene: CSF1R
UniProt: P07333 (CSF1R_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.55
Assay: Binding constant for CSF1R kinase domain
Drug: sorafenib
Target: Platelet-derived growth factor receptor alpha (Kinase)
Gene: PDGFRA
UniProt: P16234 (PGFRA_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.21
Assay: Binding constant for PDGFRA kinase domain
Drug: sorafenib
Target: Cyclin-dependent kinase 2 (Kinase)
Gene: CDK2
UniProt: P24941 (CDK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.06
Assay: Binding constant for CDK2 kinase domain
Drug: sorafenib
Target: Insulin receptor (Kinase)
Gene: INSR
UniProt: P06213 (INSR_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.28
Action type: AGONIST
Assay: Inhibition of recombinant INSR by radioactive phosphotransfer assay in presence of 10 uM ATP
Drug: sorafenib
Target: Fibroblast growth factor receptor 3 (Kinase)
Gene: FGFR3
UniProt: P22607 (FGFR3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.38
Assay: Binding constant for FGFR3 kinase domain
Drug: sorafenib
Target: Tyrosine-protein kinase HCK (Kinase)
Gene: HCK
UniProt: P08631 (HCK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.07
Assay: Binding constant for HCK kinase domain
Drug: sorafenib
Target: High affinity nerve growth factor receptor (Kinase)
Gene: NTRK1
UniProt: P04629 (NTRK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.44
Assay: Average Binding Constant for NTRK1; NA=Not Active at 10 uM
Drug: sorafenib
Target: Myosin light chain kinase 2, skeletal/cardiac muscle (Kinase)
Gene: MYLK2
UniProt: Q9H1R3 (MYLK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.89
Assay: Average Binding Constant for MYLK2; NA=Not Active at 10 uM
Drug: sorafenib
Target: Tyrosine-protein kinase CSK (Kinase)
Gene: CSK
UniProt: P41240 (CSK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.54
Assay: Binding affinity to CSK
Drug: sorafenib
Target: Angiopoietin-1 receptor (Kinase)
Gene: TEK
UniProt: Q02763 (TIE2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.68
Assay: Binding constant for TIE2 kinase domain
Drug: sorafenib
Target: Ephrin type-A receptor 8 (Kinase)
Gene: EPHA8
UniProt: P29322 (EPHA8_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.02
Assay: Average Binding Constant for EPHA8; NA=Not Active at 10 uM
Drug: sorafenib
Target: Hepatocyte growth factor receptor (Kinase)
Gene: MET
UniProt: P08581 (MET_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.24
Assay: Inhibition of human c-MET incubated for 2 hrs by ELISA method
Drug: sorafenib
Target: Tyrosine-protein kinase Lyn (Kinase)
Gene: LYN
UniProt: P07948 (LYN_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.52
Assay: Binding constant for LYN kinase domain
Drug: sorafenib
Target: LIM domain kinase 1 (Kinase)
Gene: LIMK1
UniProt: P53667 (LIMK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.8
Assay: Binding constant for full-length LIMK1