AIM-Harvard/TrialPanorama-filtered huggingface dataset:
Drug: methylatropine
Target: Muscarinic acetylcholine receptor M2 (GPCR)
Gene: Chrm2
UniProt: P10980 (ACM2_RAT)
Organism: Rattus norvegicus
Activity: Kd = 8.57
Assay: In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine
Drug: methylatropine
Target: Muscarinic acetylcholine receptor M1 (GPCR)
Gene: Chrm1
UniProt: P08482 (ACM1_RAT)
Organism: Rattus norvegicus
Activity: Kd = 8.6
Assay: In vitro receptor binding against Muscarinic acetylcholine receptor M1 in rat cerebral cortex was determined using [3H]pirenzepine
Drug: methylatropine
Target: Muscarinic acetylcholine receptor M3 (GPCR)
Gene: Chrm3
UniProt: P08483 (ACM3_RAT)
Organism: Rattus norvegicus
Activity: Kd = 8.59
Assay: In vitro receptor binding against Muscarinic acetylcholine receptor M3 in rat submandibular gland was determined using [3H]pirenzepine
Drug: methylatropine
Target: Muscarinic acetylcholine receptor DM1 (GPCR)
Gene: mAChR-A
UniProt: P16395 (ACM1_DROME)
Organism: Drosophila melanogaster
Activity: Ki = 8.62
Drug: benzoin
Target: Liver carboxylesterase 1 (Enzyme)
Gene: CES1
UniProt: P23141 (EST1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.14
Assay: Inhibition constant against human liver carboxylesterase (hCE1) expressed in Sf21 cells using 3 mM o-NPA
Drug: benzoin
Target: Cocaine esterase (Enzyme)
Gene: CES2
UniProt: O00748 (EST2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.65
Assay: Inhibition constant against human intestinal carboxylesterase (hiCE) expressed in Sf21 cells using 3 mM o-NPA
Drug: benzoic acid
Target: Solute carrier family 22 member 20 (Transporter)
Gene: Slc22a20
UniProt: Q80UJ1 (S22AK_MOUSE)
Organism: Mus musculus
Activity: Ki = 4.86
Assay: Inhibition of mouse Oat6-mediated [3H]ES uptake in Xenopus oocytes after 1 hr
Drug: benzoic acid
Target: D-amino-acid oxidase (Enzyme)
Gene: DAO
UniProt: P14920 (OXDA_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.7
Assay: Competitive inhibition of human recombinant DAAO by Michaelis-Menten plot analysis in presence of D-serine
Drug: benzoic acid
Target: Nicotinate phosphoribosyltransferase (Enzyme)
Gene: NAPRT
UniProt: Q6XQN6 (PNCB_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.72
Assay: Inhibition of NAPRT (unknown origin)
Drug: betamethasone phosphate
Target: Histamine H1 receptor (GPCR)
Gene: HRH1
UniProt: P35367 (HRH1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.932
Assay: DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)
Drug: betamethasone phosphate
Target: Muscarinic acetylcholine receptor M1 (GPCR)
Gene: CHRM1
UniProt: P11229 (ACM1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.776
Assay: DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine)
Drug: betamethasone phosphate
Target: Muscarinic acetylcholine receptor M3 (GPCR)
Gene: CHRM3
UniProt: P20309 (ACM3_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.866
Assay: DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)
Drug: betamethasone phosphate
Target: Muscarinic acetylcholine receptor M4 (GPCR)
Gene: CHRM4
UniProt: P08173 (ACM4_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.779
Assay: DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine)
Drug: betamethasone phosphate
Target: Muscarinic acetylcholine receptor M5 (GPCR)
Gene: CHRM5
UniProt: P08912 (ACM5_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.248
Assay: DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)
Drug: betamethasone phosphate
Target: Glucocorticoid receptor (Nuclear hormone receptor)
Gene: NR3C1
UniProt: P04150 (GCR_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.428
Action type: AGONIST
Assay: DRUGMATRIX: Glucocorticoid radioligand binding (ligand: [3H] Dexamethasone)
Drug: metizoline
Target: Nischarin (Membrane receptor)
Gene: NISCH
UniProt: Q9Y2I1 (NISCH_HUMAN)
Organism: Homo sapiens
Activity: Ki = 9.2
Drug: metizoline
Target: Amine oxidase [flavin-containing] B (Enzyme)
Gene: Maob
UniProt: P19643 (AOFB_RAT)
Organism: Rattus norvegicus
Activity: Ki = 5.83
Drug: metizoline
Target: Amine oxidase [flavin-containing] A (Enzyme)
Gene: Maoa
UniProt: P21396 (AOFA_RAT)
Organism: Rattus norvegicus
Activity: Ki = 4.86
Drug: metizoline
Target: Nischarin (Unclassified)
Gene: Nisch
UniProt: Q4G017 (NISCH_RAT)
Organism: Rattus norvegicus
Activity: Ki = 8.89
Drug: nalfurafine
Target: Orexin receptor type 1 (GPCR)
Gene: HCRTR1
UniProt: O43613 (OX1R_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.6
Assay: Antagonist activity at human OX1R expressed in CHOK1 cells assessed as inhibition of orexin A-induced intracellular calcium level preincubated for 15 mins followed by orexin A addition by Fura-2-AM dye based fluorescence assay
Drug: nalfurafine
Target: Mu-type opioid receptor (GPCR)
Gene: OPRM1
UniProt: P35372 (OPRM_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 9.14
Drug: nalfurafine
Target: Delta-type opioid receptor (GPCR)
Gene: OPRD1
UniProt: P41143 (OPRD_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 7.13
Drug: nalfurafine
Target: Nociceptin receptor (GPCR)
Gene: OPRL1
UniProt: P41146 (OPRX_HUMAN)
Organism: Homo sapiens
Activity: Ki  6.833
Drug: nalfurafine
Target: Mitogen-activated protein kinase 3 (Kinase)
Gene: MAPK3
UniProt: P27361 (MK03_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 9.26
Assay: Inhibition of ERK1 phosphorylation (unknown origin)
Drug: nalfurafine
Target: Mitogen-activated protein kinase 1 (Kinase)
Gene: MAPK1
UniProt: P28482 (MK01_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 9.26
Assay: Inhibition of ERK2 phosphorylation (unknown origin)
Drug: nalfurafine
Target: Mu-type opioid receptor (GPCR)
Gene: Oprm1
UniProt: P42866 (OPRM_MOUSE)
Organism: Mus musculus
Activity: Ki = 9.37
Assay: Displacement of [3H]DAMGO from mu opioid receptor in mouse whole brain without cerebellum
Drug: nalfurafine
Target: Mu-type opioid receptor (GPCR)
Gene: OPRM1
UniProt: P97266 (OPRM_CAVPO)
Organism: Cavia porcellus
Activity: Ki = 9.24
Assay: Displacement of [3H]DAMGO from mu opioid receptor in guinea pig forebrain
Drug: nalfurafine
Target: Delta-type opioid receptor (GPCR)
Gene: Oprd1
UniProt: P32300 (OPRD_MOUSE)
Organism: Mus musculus
Activity: Ki = 7.29
Assay: Displacement of [3H]DPDPE from delta opioid receptor in mouse whole brain membranes without cerebellum
Drug: nalfurafine
Target: Delta-type opioid receptor (GPCR)
Gene: Oprd1
UniProt: P33533 (OPRD_RAT)
Organism: Rattus norvegicus
Activity: Ki = 9.43
Drug: nalfurafine
Target: Kappa-type opioid receptor (GPCR)
Gene: OPRK1
UniProt: P41144 (OPRK_CAVPO)
Organism: Cavia porcellus
Activity: Ki = 9.75
Assay: Displacement of [3H]U69593 from kappa opioid receptor in guinea pig cerebellum
Drug: nalfurafine
Target: Kappa-type opioid receptor (GPCR)
Gene: Oprk1
UniProt: P34975 (OPRK_RAT)
Organism: Rattus norvegicus
Activity: EC50 = 9.3
Assay: Agonist activity at GFP-tagged rat kappa opioid receptor expressed in HEK293 cells assessed as increase in ERK1/2 phosphorylation after 5 mins by Western blot analysis
Drug: nalfurafine
Target: Kappa-type opioid receptor (GPCR)
Gene: Oprk1
UniProt: P33534 (OPRK_MOUSE)
Organism: Mus musculus
Activity: Ki = 9.75
Drug: nalfurafine
Target: Kappa-type opioid receptor (GPCR)
Gene: OPRK1
UniProt: P41145 (OPRK_HUMAN)
Organism: Homo sapiens
Activity: Ki = 9.64
Action type: AGONIST
Assay: Binding affinity to kappa opioid receptor
Drug: obidoxime
Target: Acetylcholinesterase (Enzyme)
Gene: ACHE
UniProt: P22303 (ACES_HUMAN)
Organism: Homo sapiens
Activity: Kd = 4.67
Assay: Binding affinity to sarin-inhibited hemoglobin free human erythrocyte ghost acetylcholinesterase using acetylthiocholineiodide as substrate measured up to 1 hr by Ellman method
Drug: panobinostat
Target: Histone deacetylase (Enzyme)
Gene: HDAC1
UniProt: Q9XYC7 (Q9XYC7_PLAFA)
Organism: Plasmodium falciparum
Activity: IC50 = 8.74
Assay: Inhibition of Plasmodium falciparum HDAC1 expressed in Drosophila melanogaster S2 cells
Drug: panobinostat
Target: Bromodomain-containing protein 4 (Unclassified)
Gene: BRD4
UniProt: O60885 (BRD4_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 8.3
Assay: Inhibition of BRD4 (unknown origin)
Drug: panobinostat
Target: Histone deacetylase 8 (Unclassified)
Gene: HDAC8
UniProt: A5H660 (A5H660_SCHMA)
Organism: Schistosoma mansoni
Activity: IC50 = 6.35
Assay: Inhibition of Schistosoma mansoni KDAC8 using (FAM)-labeled peptide as substrate after 60 mins by microfluidic assay
Drug: panobinostat
Target: Histone deacetylase 5 (Enzyme)
Gene: HDAC5
UniProt: Q9UQL6 (HDAC5_HUMAN)
Organism: Homo sapiens
Activity: Ki = 9.15
Action type: INHIBITOR
Assay: Competitive inhibition of HDAC5 using KI-104 as substrate by fluorescence assay
Drug: panobinostat
Target: Histone deacetylase 2 (Enzyme)
Gene: HDAC2
UniProt: Q92769 (HDAC2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 9.19
Action type: INHIBITOR
Assay: Inhibition of human HDAC2
Drug: panobinostat
Target: Histone deacetylase 1 (Enzyme)
Gene: HDAC1
UniProt: Q13547 (HDAC1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 9
Action type: INHIBITOR
Assay: Inhibition of human HDAC1
Drug: panobinostat
Target: Histone deacetylase 3 (Enzyme)
Gene: HDAC3
UniProt: O15379 (HDAC3_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.96
Action type: INHIBITOR
Assay: Inhibition of human HDAC3
Drug: panobinostat
Target: Histone deacetylase 6 (Enzyme)
Gene: HDAC6
UniProt: Q9UBN7 (HDAC6_HUMAN)
Organism: Homo sapiens
Activity: Ki = 9.15
Action type: INHIBITOR
Assay: Competitive inhibition of HDAC6 using KI-104 as substrate by fluorescence assay
Drug: panobinostat
Target: Histone deacetylase 7 (Enzyme)
Gene: HDAC7
UniProt: Q8WUI4 (HDAC7_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.64
Action type: INHIBITOR
Assay: Competitive inhibition of HDAC7 using KI-104 as substrate by fluorescence assay
Drug: panobinostat
Target: Histone deacetylase 8 (Enzyme)
Gene: HDAC8
UniProt: Q9BY41 (HDAC8_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.66
Action type: INHIBITOR
Assay: Competitive inhibition of HDAC8 using KI-104 as substrate by fluorescence assay
Drug: panobinostat
Target: Histone deacetylase 4 (Enzyme)
Gene: HDAC4
UniProt: P56524 (HDAC4_HUMAN)
Organism: Homo sapiens
Activity: Ki = 9.22
Action type: INHIBITOR
Assay: Competitive inhibition of HDAC4 using KI-104 as substrate by fluorescence assay
Drug: panobinostat
Target: Histone deacetylase 9 (Enzyme)
Gene: HDAC9
UniProt: Q9UKV0 (HDAC9_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.92
Action type: INHIBITOR
Assay: Competitive inhibition of HDAC9 using KI-104 as substrate by fluorescence assay
Drug: panobinostat
Target: Histone deacetylase 10 (Enzyme)
Gene: HDAC10
UniProt: Q969S8 (HDA10_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.51
Action type: INHIBITOR
Assay: Competitive inhibition of HDAC10 using KI-104 as substrate by fluorescence assay
Drug: panobinostat
Target: Histone deacetylase 11 (Enzyme)
Gene: HDAC11
UniProt: Q96DB2 (HDA11_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.46
Action type: INHIBITOR
Assay: Competitive inhibition of HDAC11 using KI-104 as substrate by fluorescence assay
Drug: paraoxon
Target: Carbonic anhydrase 2 (Enzyme)
Gene: CA2
UniProt: P00918 (CAH2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7.23
Assay: Inhibition of esterase activity of human carbonic anhydrase 2 by CO2 hydration method
Drug: paraoxon
Target: Carbonic anhydrase 1 (Enzyme)
Gene: CA1
UniProt: P00915 (CAH1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.47
Assay: Inhibition of esterase activity of human carbonic anhydrase 1 by CO2 hydration method
Drug: paraoxon
Target: Acetylcholinesterase (Enzyme)
Gene: ACHE
UniProt: P22303 (ACES_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 8
Assay: Inhibition of human AChE using p-nitrophenyl acetate as substrate measured for 30 secs by spectrophotometric analysis
Drug: paraoxon
Target: Cholinesterase (Enzyme)
Gene: BCHE
UniProt: P06276 (CHLE_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 8.15
Assay: Inhibition of human BChE using butyrylthiocholine as substrate measured for 30 secs by Ellman's method
Drug: paraoxon
Target: Carbonic anhydrase 13 (Enzyme)
Gene: Ca13
UniProt: Q9D6N1 (CAH13_MOUSE)
Organism: Mus musculus
Activity: IC50 = 5.99
Assay: Inhibition of esterase activity of mouse carbonic anhydrase 13 by CO2 hydration method
Drug: paraoxon
Target: Acetylcholinesterase (Enzyme)
Gene: Ache
UniProt: P21836 (ACES_MOUSE)
Organism: Mus musculus
Activity: IC50 = 7.89
Assay: Displacement of acetylcholine from AChE in Swiss Webster mouse brain after 5 mins
Drug: paraoxon
Target: Cannabinoid receptor 1 (GPCR)
Gene: Cnr1
UniProt: P47746 (CNR1_MOUSE)
Organism: Mus musculus
Activity: IC50 = 5.92
Assay: Displacement of [3H]CP-55940 from CB1 receptor in mouse brain
Drug: paraoxon
Target: Monoglyceride lipase (Enzyme)
Gene: Mgll
UniProt: O35678 (MGLL_MOUSE)
Organism: Mus musculus
Activity: IC50 = 5.92
Assay: Displacement of 2-arachidonylglycerol from MAGL in Swiss Webster mouse brain after 5 mins
Drug: paraoxon
Target: Fatty-acid amide hydrolase 1 (Enzyme)
Gene: Faah
UniProt: O08914 (FAAH1_MOUSE)
Organism: Mus musculus
Activity: IC50 = 6.27
Assay: Inhibition of FAAH-mediated [3H]anandamide hydrolysis in mouse brain
Drug: perampanel
Target: Glutamate receptor ionotropic AMPA (Ion channel)
Gene: GRIA1|GRIA2|GRIA3|GRIA4
UniProt: P42261|P42262|P42263|P48058 (GRIA1_HUMAN|GRIA2_HUMAN|GRIA3_HUMAN|GRIA4_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.61
Action type: ANTAGONIST
Assay: Antagonist activity at human iGluA1 receptor flop isoform expressed in CHO-S cells coexpressing TARP gamma-3 assessed as inhibition of glutamate-induced increase in intracellular calcium levels after 2 mins followed by cyclothiazide/glutamate addition by fluorescence imaging plate reader method
Drug: pleconaril
Target: Nuclear receptor subfamily 1 group I member 2 (Nuclear hormone receptor)
Gene: NR1I2
UniProt: O75469 (NR1I2_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 6.6
Assay: Activation of human PXR expressed in african green monkey CV1 cells transfected with pSG5-hPXRDATG and (ER6)3-tk-CAT reporter
Drug: pleconaril
Target: Protease (Enzyme)
Gene: protease
UniProt: Q4U254 (Q4U254_9ENTO)
Organism: Human rhinovirus sp
Activity: EC50 = 7.24
Assay: Inhibition of HRV Protease 3CP (serotype 14).
Drug: pleconaril
Target: Genome polyprotein (Unclassified)
UniProt: Q7T664 (Q7T664_HRV1A)
Organism: Human rhinovirus 1A
Activity: EC50 = 8.4
Assay: Inhibition of Rhinovirus A89 capsid infected in human HeLa Rh cells assessed as reduction in virus-induced cytopathic effect after 3 days by MTS assay
Drug: remikiren
Target: Renin (Enzyme)
Gene: REN
UniProt: P00797 (RENI_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 9.155
Action type: INHIBITOR
Assay: purified human renin
Drug: esatenolol
Target: Beta-1 adrenergic receptor (GPCR)
Gene: ADRB1
UniProt: P08588 (ADRB1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.82
Assay: Binding affinity to human adrenergic beta1 receptor by radioligand displacement assay
Drug: esatenolol
Target: Beta-2 adrenergic receptor (GPCR)
Gene: ADRB2
UniProt: P07550 (ADRB2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5
Assay: DRUGMATRIX: Adrenergic beta2 radioligand binding (ligand: [3H] CGP-12177)
Drug: esatenolol
Target: Adenosine receptor A3 (GPCR)
Gene: ADORA3
UniProt: P0DMS8 (AA3R_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 8.75
Assay: Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug: esatenolol
Target: 5-hydroxytryptamine receptor 1A (GPCR)
Gene: Htr1a
UniProt: P19327 (5HT1A_RAT)
Organism: Rattus norvegicus
Activity: Ki = 5
Assay: Binding affinity of a compound to rat brain 5-hydroxytryptamine 1A (serotonin) receptor assayed by radiolabeled [3H]-8-OH-DPAT ligand displacement
Drug: esatenolol
Target: Beta-2 adrenergic receptor (GPCR)
Gene: Adrb2
UniProt: Q8K4Z4 (ADRB2_CAVPO)
Organism: Cavia porcellus
Activity: Kd = 5.93
Assay: In vitro beta-2 adrenergic receptor activity was determined by measuring inhibition of the isoproterenol induced relaxation in isolated guinea pig tracheal chains contracted with PGF2-alpha
Drug: esatenolol
Target: Beta-1 adrenergic receptor (GPCR)
Gene: ADRB1
UniProt: B0FL73 (B0FL73_CAVPO)
Organism: Cavia porcellus
Activity: Kd = 7.62
Assay: In vitro beta-1 adrenergic receptor activity was determined via inhibition of the positive chronotropic actions of isoproterenol in isolated guinea pig atrial preparations
Drug: semustine
Target: Alpha-2A adrenergic receptor (GPCR)
Gene: ADRA2A
UniProt: P08913 (ADA2A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.744
Assay: DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)
Drug: sodium aurothiomalate
Target: Adenosine receptor A3 (GPCR)
Gene: ADORA3
UniProt: P0DMS8 (AA3R_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.074
Assay: DRUGMATRIX: Adenosine A3 radioligand binding (ligand: AB-MECA)
Drug: sodium aurothiomalate
Target: Thioredoxin reductase 1, cytoplasmic (Enzyme)
Gene: TXNRD1
UniProt: Q16881 (TRXR1_HUMAN)
Organism: Homo sapiens
Drug: sodium aurothiomalate
Target: Epidermal growth factor receptor (Kinase)
Gene: EGFR
UniProt: P00533 (EGFR_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.624
Assay: DRUGMATRIX: Protein Tyrosine Kinase, EGF Receptor enzyme inhibition (substrate: Poly(Glu:Tyr))
Drug: sodium aurothiomalate
Target: Tyrosine-protein kinase Fyn (Kinase)
Gene: FYN
UniProt: P06241 (FYN_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.091
Assay: DRUGMATRIX: Protein Tyrosine Kinase, Fyn enzyme inhibition (substrate: Poly(Glu:Tyr))
Drug: sodium aurothiomalate
Target: Cathepsin L1 (Enzyme)
Gene: CTSL
UniProt: P07711 (CATL1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.05
Assay: Inhibitory concentration against human liver cathepsin L
Drug: somatorelin
Target: Vasoactive intestinal polypeptide receptor 1 (GPCR)
Gene: VIPR1
UniProt: P32241 (VIPR1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.2
Action type: AGONIST
Assay: inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Drug: tofacitinib
Target: Tyrosine-protein kinase JAK3 (Kinase)
Gene: JAK3
UniProt: P52333 (JAK3_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 8.481
Action type: INHIBITOR
Drug: tofacitinib
Target: Tyrosine-protein kinase ABL1 (Kinase)
Gene: ABL1
UniProt: P00519 (ABL1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.66
Assay: Binding constant for ABL1(T315I)-phosphorylated kinase domain
Drug: tofacitinib
Target: Tyrosine-protein kinase Lck (Kinase)
Gene: LCK
UniProt: P06239 (LCK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.34
Assay: Binding constant for LCK kinase domain
Drug: tofacitinib
Target: Tyrosine-protein kinase Fyn (Kinase)
Gene: FYN
UniProt: P06241 (FYN_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.96
Assay: Binding constant for FYN kinase domain
Drug: tofacitinib
Target: Proto-oncogene tyrosine-protein kinase receptor Ret (Kinase)
Gene: RET
UniProt: P07949 (RET_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.48
Assay: Binding constant for RET(M918T) kinase domain
Drug: tofacitinib
Target: Calcium/calmodulin-dependent protein kinase type 1 (Kinase)
Gene: CAMK1
UniProt: Q14012 (KCC1A_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.92
Assay: Binding constant for CAMK1 kinase domain
Drug: tofacitinib
Target: Rho-associated protein kinase 1 (Kinase)
Gene: ROCK1
UniProt: Q13464 (ROCK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.33
Assay: Binding constant for ROCK1 kinase domain
Drug: tofacitinib
Target: Tyrosine-protein kinase JAK1 (Kinase)
Gene: JAK1
UniProt: P23458 (JAK1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 9.17
Action type: INHIBITOR
Assay: Inhibition of human recombinant GST-tagged JAK1 using 5-FAM-KKSRGDYMTMQIG as substrate by peptide mobility shift assay
Drug: tofacitinib
Target: Protein kinase C delta type (Kinase)
Gene: PRKCD
UniProt: Q05655 (KPCD_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.7
Assay: Binding constant for PRKCD kinase domain
Drug: tofacitinib
Target: Tyrosine-protein kinase JAK2 (Kinase)
Gene: JAK2
UniProt: O60674 (JAK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 9.24
Action type: INHIBITOR
Assay: Binding constant for JAK2(JH1domain-catalytic) kinase domain
Drug: tofacitinib
Target: Rho-associated protein kinase 2 (Kinase)
Gene: ROCK2
UniProt: O75116 (ROCK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.38
Assay: Binding constant for ROCK2 kinase domain
Drug: tofacitinib
Target: Calcium/calmodulin-dependent protein kinase type II subunit delta (Kinase)
Gene: CAMK2D
UniProt: Q13557 (KCC2D_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.57
Assay: Binding constant for CAMK2D kinase domain
Drug: tofacitinib
Target: Ribosomal protein S6 kinase alpha-2 (Kinase)
Gene: RPS6KA2
UniProt: Q15349 (KS6A2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.22
Assay: Binding constant for RSK3(Kin.Dom.2-C-terminal) kinase domain
Drug: tofacitinib
Target: Calcium/calmodulin-dependent protein kinase type II subunit alpha (Kinase)
Gene: CAMK2A
UniProt: Q9UQM7 (KCC2A_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.46
Assay: Binding constant for CAMK2A kinase domain
Drug: tofacitinib
Target: Serine/threonine-protein kinase N1 (Kinase)
Gene: PKN1
UniProt: Q16512 (PKN1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.77
Assay: Binding constant for PKN1 kinase domain
Drug: tofacitinib
Target: BMP-2-inducible protein kinase (Kinase)
Gene: BMP2K
UniProt: Q9NSY1 (BMP2K_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.15
Assay: Binding constant for BIKE kinase domain
Drug: tofacitinib
Target: Calcium/calmodulin-dependent protein kinase type 1D (Kinase)
Gene: CAMK1D
UniProt: Q8IU85 (KCC1D_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.8
Assay: Binding constant for CAMK1D kinase domain
Drug: tofacitinib
Target: MAP kinase-interacting serine/threonine-protein kinase 2 (Kinase)
Gene: MKNK2
UniProt: Q9HBH9 (MKNK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.8
Assay: Binding constant for MKNK2 kinase domain
Drug: tofacitinib
Target: Serine/threonine-protein kinase N2 (Kinase)
Gene: PKN2
UniProt: Q16513 (PKN2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.92
Assay: Binding constant for PKN2 kinase domain
Drug: tofacitinib
Target: Serine/threonine-protein kinase DCLK3 (Kinase)
Gene: DCLK3
UniProt: Q9C098 (DCLK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.35
Assay: Binding affinity to DCamkL3
Drug: tofacitinib
Target: Serine/threonine-protein kinase 3 (Kinase)
Gene: STK3
UniProt: Q13188 (STK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.37
Assay: Binding affinity to MST2
Drug: tofacitinib
Target: Ribosomal protein S6 kinase alpha-6 (Kinase)
Gene: RPS6KA6
UniProt: Q9UK32 (KS6A6_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.27
Assay: Binding constant for RSK4(Kin.Dom.2-C-terminal) kinase domain
Drug: tofacitinib
Target: NUAK family SNF1-like kinase 2 (Kinase)
Gene: NUAK2
UniProt: Q9H093 (NUAK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.62
Assay: Binding constant for SNARK kinase domain
Drug: tofacitinib
Target: Non-receptor tyrosine-protein kinase TNK1 (Kinase)
Gene: TNK1
UniProt: Q13470 (TNK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.92
Assay: Binding constant for TNK1 kinase domain
Drug: tofacitinib
Target: Non-receptor tyrosine-protein kinase TYK2 (Kinase)
Gene: TYK2
UniProt: P29597 (TYK2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.36
Action type: INHIBITOR
Assay: Inhibition of human recombinant GST-tagged TYK2 using 5-FAM-KKSRGDYMTMQIG as substrate by peptide mobility shift assay
Drug: tofacitinib
Target: Myotonin-protein kinase (Kinase)
Gene: DMPK
UniProt: Q09013 (DMPK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.92
Assay: Binding constant for DMPK kinase domain
Drug: tofacitinib
Target: Serine/threonine-protein kinase DCLK1 (Kinase)
Gene: DCLK1
UniProt: O15075 (DCLK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.17
Assay: Binding constant for DCAMKL1 kinase domain
Drug: tofacitinib
Target: Ribosomal protein S6 kinase alpha-1 (Kinase)
Gene: RPS6KA1
UniProt: Q15418 (KS6A1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.85
Assay: Binding constant for RSK1(Kin.Dom.2-C-terminal) kinase domain
Drug: tofacitinib
Target: Mitogen-activated protein kinase kinase kinase kinase 2 (Kinase)
Gene: MAP4K2
UniProt: Q12851 (M4K2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.32
Assay: Binding constant for MAP4K2 kinase domain
Drug: tofacitinib
Target: G protein-coupled receptor kinase 7 (Kinase)
Gene: GRK7
UniProt: Q8WTQ7 (GRK7_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.37
Assay: Binding constant for GRK7 kinase domain