AIM-Harvard/TrialPanorama-filtered huggingface dataset:
Drug: sultiame
Target: Carbonic anhydrase 1 (Enzyme)
Gene: CA1
UniProt: P00915 (CAH1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.43
Assay: Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration method
Drug: sultiame
Target: Carbonic anhydrase 9 (Enzyme)
Gene: CA9
UniProt: Q16790 (CAH9_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.37
Assay: Inhibition of human recombinant carbonic anhydrase 9 catalytic domain by stopped flow CO2 hydrase assay
Drug: sultiame
Target: Carbonic anhydrase 6 (Enzyme)
Gene: CA6
UniProt: P23280 (CAH6_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.87
Assay: Inhibition of human full length recombinant carbonic anhydrase 6 by stopped flow CO2 hydrase assay
Drug: sultiame
Target: Carbonic anhydrase 15 (Enzyme)
Gene: Ca15
UniProt: Q99N23 (CAH15_MOUSE)
Organism: Mus musculus
Activity: Ki = 7.19
Assay: Inhibition of mouse recombinant carbonic anhydrase 15 by stopped flow CO2 hydrase assay
Drug: sultiame
Target: Carbonic anhydrase (Enzyme)
Gene: NCE103
UniProt: P53615 (CAN_YEAST)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Activity: Ki = 5.99
Assay: Inhibition of Saccharomyces cerevisiae recombinant CA expressed in Escherichia coli by stopped-flow CO2 hydrase assay
Drug: sultiame
Target: Carbonic anhydrase (Enzyme)
Gene: NCE103
UniProt: Q5AJ71 (CAN_CANAL)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876)
Activity: Ki = 8.05
Assay: Inhibition of Helicobacter pylori beta-carbonic anhydrase by stopped-flow CO2 hydration assay
Drug: sultiame
Target: Alpha carbonic anhydrase (Enzyme)
Gene: CA
UniProt: B5SU02 (B5SU02_9CNID)
Organism: Stylophora pistillata
Activity: Ki = 7.34
Assay: Inhibition of cloned Stylophora pistillata alpha-CA expressed in human HEK293 cells by stopped-flow CO2 assay
Drug: sultiame
Target: Carbonic anhydrase (Enzyme)
Gene: CA2
UniProt: C0IX24 (C0IX24_9CNID)
Organism: Stylophora pistillata
Activity: Ki = 6.91
Assay: Inhibition of Stylophora pistillata carbonic anhydrase 2 by stopped-flow CO2 hydration assay
Drug: sultiame
Target: Astrosclerin-3 (Enzyme)
UniProt: A6YCJ1 (A6YCJ1_9METZ)
Organism: Astrosclera willeyana
Activity: Ki = 6.56
Assay: Inhibition of GST-tagged astrosclera willeyana Astrosclerin-3 expressed in Escherichia coli after 15 mins preincubation by stopped flow CO2 hydration assay
Drug: sultiame
Target: Beta-carbonic anhydrase 1 (Enzyme)
Gene: mtcA1
UniProt: P9WPJ7 (MTCA1_MYCTU)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Activity: Ki = 5.29
Assay: Inhibition of Mycobacterium tuberculosis recombinant carbonic anhydrase 1 encoded by Rv1284 by stopped flow CO2 hydration assay
Drug: sultiame
Target: Delta carbonic anhydrase (Unclassified)
Gene: ca1
UniProt: Q5U9J1 (Q5U9J1_THAWE)
Organism: Thalassiosira weissflogii
Activity: Ki = 6.77
Assay: Inhibition of Thalassiosira weissflogii delta carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration assay
Drug: sultiame
Target: Carbonic anhydrase 2 (Enzyme)
Gene: mtcA2
UniProt: P9WPJ9 (MTCA2_MYCTU)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Activity: Ki = 6.18
Assay: Inhibition of full length Mycobacterium tuberculosis H37Rv recombinant carbonic anhydrase 2 encoded by RV3588c by stopped flow CO2 hydration assay
Drug: sultiame
Target: Carbonic anhydrase (Enzyme)
UniProt: Q5TU56 (Q5TU56_ANOGA)
Organism: Anopheles gambiae
Activity: Ki = 6.58
Drug: sultiame
Target: Carbonic anhydrase, alpha family (Unclassified)
UniProt: Q31FD6 (Q31FD6_HYDCU)
Organism: Hydrogenovibrio crunogenus (strain XCL-2)
Activity: Ki = 6.37
Assay: Inhibition of recombinant Thiomicrospira crunogena XCL-2 carbonic anhydrase by stopped flow CO2 hydrase assay
Drug: sultiame
Target: Carbonate dehydratase (Enzyme)
UniProt: B2V8E3 (B2V8E3_SULSY)
Organism: Sulfurihydrogenibium sp. (strain YO3AOP1)
Activity: Ki = 8.11
Assay: Inhibition of recombinant Sulfurihydrogenibium yellowstonense YO3AOP1 carbonic anhydrase by stopped flow CO2 hydrase assay
Drug: sultopride
Target: D(2) dopamine receptor (GPCR)
Gene: DRD2
UniProt: P14416 (DRD2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.571
Drug: sultopride
Target: D(3) dopamine receptor (GPCR)
Gene: DRD3
UniProt: P35462 (DRD3_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.42
Drug: sumatriptan
Target: 5-hydroxytryptamine receptor 1A (GPCR)
Gene: HTR1A
UniProt: P08908 (5HT1A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.64
Assay: In vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1A receptor
Drug: sumatriptan
Target: 5-hydroxytryptamine receptor 2A (GPCR)
Gene: HTR2A
UniProt: P28223 (5HT2A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.42
Assay: The compound was tested for CNS binding affinity towards 5-hydroxytryptamine 2A receptor from cloned Human membranes
Drug: sumatriptan
Target: 5-hydroxytryptamine receptor 2C (GPCR)
Gene: HTR2C
UniProt: P28335 (5HT2C_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 8.14
Assay: Compound was evaluated for the affinity at 5-hydroxytryptamine 2C receptor
Drug: sumatriptan
Target: 5-hydroxytryptamine receptor 6 (GPCR)
Gene: HTR6
UniProt: P50406 (5HT6R_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.6
Action type: ANTAGONIST
Drug: sumatriptan
Target: 5-hydroxytryptamine receptor 7 (GPCR)
Gene: HTR7
UniProt: P34969 (5HT7R_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6
Action type: ANTAGONIST
Drug: sumatriptan
Target: 5-hydroxytryptamine receptor 1B (GPCR)
Gene: HTR1B
UniProt: P28222 (5HT1B_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.26
Action type: AGONIST
Assay: Binding affinity was measured on 5-hydroxytryptamine 1D receptor beta in CHO cells transfected with human 5-HT1D beta gene labeled with [3H]5-HT
Drug: sumatriptan
Target: 5-hydroxytryptamine receptor 1D (GPCR)
Gene: HTR1D
UniProt: P28221 (5HT1D_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.92
Action type: AGONIST
Assay: Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting
Drug: sumatriptan
Target: 5-hydroxytryptamine receptor 3A (Ion channel)
Gene: HTR3A
UniProt: P46098 (5HT3A_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 8.03
Assay: Compound was evaluated for the affinity at 5-hydroxytryptamine 3 receptor
Drug: sumatriptan
Target: 5-hydroxytryptamine receptor 5A (GPCR)
Gene: HTR5A
UniProt: P47898 (5HT5A_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.3
Assay: Displacement of [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor from pig cortex
Drug: sumatriptan
Target: 5-hydroxytryptamine receptor 1F (GPCR)
Gene: HTR1F
UniProt: P30939 (5HT1F_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.59
Assay: Binding affinity towards human 5-hydroxytryptamine 1F receptor was determined
Drug: sumatriptan
Target: 5-hydroxytryptamine receptor 1E (GPCR)
Gene: HTR1E
UniProt: P28566 (5HT1E_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.26
Assay: Compound was evaluated for the affinity at 5-hydroxytryptamine 1E receptor
Drug: sumatriptan
Target: 5-hydroxytryptamine receptor 1B (GPCR)
Gene: Htr1b
UniProt: P28564 (5HT1B_RAT)
Organism: Rattus norvegicus
Activity: Ki = 7.64
Assay: Binding affinity was measured on 5-hydroxytryptamine 1B receptor in rat striatum labeled with [3H]5-HT
Drug: sumatriptan
Target: 5-hydroxytryptamine receptor 1A (GPCR)
Gene: Htr1a
UniProt: P19327 (5HT1A_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 6.19
Assay: Binding affinity was measured against serotonin 5-hydroxytryptamine 1A receptor
Drug: sumatriptan
Target: 5-hydroxytryptamine receptor 7 (GPCR)
Gene: Htr7
UniProt: P32305 (5HT7R_RAT)
Organism: Rattus norvegicus
Activity: Ki = 6.6
Action type: ANTAGONIST
Drug: sumatriptan
Target: 5-hydroxytryptamine receptor 1D (GPCR)
Gene: HTR1D
UniProt: P79400 (5HT1D_PIG)
Organism: Sus scrofa
Activity: IC50 = 7.7
Assay: Binding activity radioligand.
Drug: sumatriptan
Target: 5-hydroxytryptamine receptor 1A (GPCR)
Gene: Htr1a
UniProt: Q64264 (5HT1A_MOUSE)
Organism: Mus musculus
Activity: IC50 = 6.35
Assay: Compound was evaluated for the affinity at 5-hydroxytryptamine 1A receptor
Drug: sumatriptan
Target: 5-hydroxytryptamine receptor 1D (GPCR)
Gene: Htr1d
UniProt: P28565 (5HT1D_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 7.21
Assay: Binding affinity was measured against serotonin 5-hydroxytryptamine 1D receptor
Drug: sumatriptan
Target: 5-hydroxytryptamine receptor 6 (GPCR)
Gene: Htr6
UniProt: P31388 (5HT6R_RAT)
Organism: Rattus norvegicus
Activity: Ki = 5.2
Action type: ANTAGONIST
Drug: sumatriptan
Target: Multidrug and toxin extrusion protein 1 (Transporter)
Gene: SLC47A1
UniProt: Q96FL8 (S47A1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.17
Assay: Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay
Drug: sumatriptan
Target: 5-hydroxytryptamine receptor 1B (GPCR)
Gene: HTR1B
UniProt: Q9N2B7 (5HT1B_GORGO)
Organism: Gorilla gorilla gorilla
Activity: Ki = 8.19
Assay: The compound was tested for CNS binding affinity towards 5-hydroxytryptamine 1B receptor from cloned gorilla membranes expressed in cultured HEK 293 cells
Drug: sumatriptan
Target: 5-hydroxytryptamine 1D receptor (Unclassified)
Gene: 5htr1d
UniProt: Q8MI13 (Q8MI13_BOVIN)
Organism: Bos taurus
Activity: IC50 = 7.23
Drug: sumatriptan
Target: 5-hydroxytryptamine receptor 5A (GPCR)
Gene: Htr5a
UniProt: P30966 (5HT5A_MOUSE)
Organism: Mus musculus
Activity: Ki = 4.8
Action type: AGONIST
Drug: sunitinib
Target: Tyrosine-protein kinase JAK3 (Kinase)
Gene: JAK3
UniProt: P52333 (JAK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.92
Assay: Binding constant for JAK3(Kin.Dom.2/JH1 - catalytic) kinase domain
Drug: sunitinib
Target: Potassium voltage-gated channel subfamily H member 2 (Ion channel)
Gene: KCNH2
UniProt: Q12809 (KCNH2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.3
Assay: Inhibition of human ERG
Drug: sunitinib
Target: Acetylcholinesterase (Enzyme)
Gene: ACHE
UniProt: P22303 (ACES_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.23
Assay: Inhibition of AChE (unknown origin)
Drug: sunitinib
Target: Platelet-derived growth factor receptor beta (Kinase)
Gene: PDGFRB
UniProt: P09619 (PGFRB_HUMAN)
Organism: Homo sapiens
Activity: Kd = 10.12
Action type: INHIBITOR
Assay: Binding constant for PDGFRB kinase domain
Drug: sunitinib
Target: Tyrosine-protein kinase ABL1 (Kinase)
Gene: ABL1
UniProt: P00519 (ABL1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.26
Assay: Binding constant for ABL1(T315I)-phosphorylated kinase domain
Drug: sunitinib
Target: Mast/stem cell growth factor receptor Kit (Kinase)
Gene: KIT
UniProt: P10721 (KIT_HUMAN)
Organism: Homo sapiens
Activity: Kd = 9.68
Action type: INHIBITOR
Assay: Binding constant for KIT(V559D,V654A) kinase domain
Drug: sunitinib
Target: Epidermal growth factor receptor (Kinase)
Gene: EGFR
UniProt: P00533 (EGFR_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.07
Assay: Binding constant for EGFR(L858R,T790M) kinase domain
Drug: sunitinib
Target: Proto-oncogene tyrosine-protein kinase Src (Kinase)
Gene: SRC
UniProt: P12931 (SRC_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.68
Assay: Binding constant for SRC kinase domain
Drug: sunitinib
Target: Tyrosine-protein kinase Lck (Kinase)
Gene: LCK
UniProt: P06239 (LCK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.64
Assay: Binding constant for LCK kinase domain
Drug: sunitinib
Target: Tyrosine-protein kinase Yes (Kinase)
Gene: YES1
UniProt: P07947 (YES_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.92
Assay: Binding constant for YES kinase domain
Drug: sunitinib
Target: Tyrosine-protein kinase Fyn (Kinase)
Gene: FYN
UniProt: P06241 (FYN_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.28
Assay: Binding constant for FYN kinase domain
Drug: sunitinib
Target: Receptor-type tyrosine-protein kinase FLT3 (Kinase)
Gene: FLT3
UniProt: P36888 (FLT3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 9.66
Action type: INHIBITOR
Assay: Binding constant for FLT3(K663Q) kinase domain
Drug: sunitinib
Target: Vascular endothelial growth factor receptor 2 (Kinase)
Gene: KDR
UniProt: P35968 (VGFR2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 9.7
Action type: INHIBITOR
Assay: Inhibition of KDR by cellular assay
Drug: sunitinib
Target: Vascular endothelial growth factor receptor 3 (Kinase)
Gene: FLT4
UniProt: P35916 (VGFR3_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.77
Action type: INHIBITOR
Assay: Binding affinity to VEGFR3 (unknown origin)
Drug: sunitinib
Target: Macrophage colony-stimulating factor 1 receptor (Kinase)
Gene: CSF1R
UniProt: P07333 (CSF1R_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.7
Action type: INHIBITOR
Assay: Binding constant for CSF1R kinase domain
Drug: sunitinib
Target: Ribosomal protein S6 kinase alpha-3 (Kinase)
Gene: RPS6KA3
UniProt: P51812 (KS6A3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.26
Assay: Average Binding Constant for RPS6KA3 (Kin.Dom. 1); NA=Not Active at 10 uM
Drug: sunitinib
Target: Phosphorylase b kinase gamma catalytic chain, liver/testis isoform (Kinase)
Gene: PHKG2
UniProt: P15735 (PHKG2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.23
Assay: Binding constant for PHKG2 kinase domain
Drug: sunitinib
Target: Insulin-like growth factor 1 receptor (Kinase)
Gene: IGF1R
UniProt: P08069 (IGF1R_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.59
Assay: Binding constant for IGF1R kinase domain
Drug: sunitinib
Target: Myosin light chain kinase, smooth muscle (Kinase)
Gene: MYLK
UniProt: Q15746 (MYLK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.64
Assay: Binding affinity to MLCK
Drug: sunitinib
Target: Insulin receptor (Kinase)
Gene: INSR
UniProt: P06213 (INSR_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.74
Action type: AGONIST
Assay: Average Binding Constant for INSR; NA=Not Active at 10 uM
Drug: sunitinib
Target: Death-associated protein kinase 3 (Kinase)
Gene: DAPK3
UniProt: O43293 (DAPK3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.66
Assay: Binding constant for DAPK3 kinase domain
Drug: sunitinib
Target: Calcium/calmodulin-dependent protein kinase type 1 (Kinase)
Gene: CAMK1
UniProt: Q14012 (KCC1A_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.01
Assay: Binding constant for full-length CAMK1
Drug: sunitinib
Target: Fibroblast growth factor receptor 3 (Kinase)
Gene: FGFR3
UniProt: P22607 (FGFR3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.54
Assay: Binding constant for FGFR3 kinase domain
Drug: sunitinib
Target: Rho-associated protein kinase 1 (Kinase)
Gene: ROCK1
UniProt: Q13464 (ROCK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.34
Assay: Binding affinity to ROCK1
Drug: sunitinib
Target: Focal adhesion kinase 1 (Kinase)
Gene: PTK2
UniProt: Q05397 (FAK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.36
Assay: Binding constant for PTK2 kinase domain
Drug: sunitinib
Target: Tyrosine-protein kinase HCK (Kinase)
Gene: HCK
UniProt: P08631 (HCK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.06
Assay: Binding constant for HCK kinase domain
Drug: sunitinib
Target: Tyrosine-protein kinase JAK1 (Kinase)
Gene: JAK1
UniProt: P23458 (JAK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.05
Assay: Inhibition of Jak1
Drug: sunitinib
Target: Mitogen-activated protein kinase 10 (Kinase)
Gene: MAPK10
UniProt: P53779 (MK10_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.37
Assay: Binding constant for JNK3 kinase domain
Drug: sunitinib
Target: Death-associated protein kinase 2 (Kinase)
Gene: DAPK2
UniProt: Q9UIK4 (DAPK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.82
Assay: Binding constant for full-length DAPK2
Drug: sunitinib
Target: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Kinase)
Gene: PIK3CD
UniProt: O00329 (PK3CD_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.92
Assay: Inhibition of recombinant PI3Kdelta by radioactive phosphotransfer assay in presence of 10 uM ATP
Drug: sunitinib
Target: High affinity nerve growth factor receptor (Kinase)
Gene: NTRK1
UniProt: P04629 (NTRK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7
Assay: Binding constant for TRKA kinase domain
Drug: sunitinib
Target: Tyrosine-protein kinase JAK2 (Kinase)
Gene: JAK2
UniProt: O60674 (JAK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.39
Assay: Binding constant for JAK2(Kin.Dom.2/JH1 - catalytic) kinase domain
Drug: sunitinib
Target: Rho-associated protein kinase 2 (Kinase)
Gene: ROCK2
UniProt: O75116 (ROCK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.85
Assay: Binding affinity to ROCK2
Drug: sunitinib
Target: Protein kinase C alpha type (Kinase)
Gene: PRKCA
UniProt: P17252 (KPCA_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.22
Assay: Average Binding Constant for PRKACA; NA=Not Active at 10 uM
Drug: sunitinib
Target: Calcium/calmodulin-dependent protein kinase type II subunit delta (Kinase)
Gene: CAMK2D
UniProt: Q13557 (KCC2D_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.38
Assay: Binding constant for CAMK2D kinase domain
Drug: sunitinib
Target: Myosin light chain kinase 2, skeletal/cardiac muscle (Kinase)
Gene: MYLK2
UniProt: Q9H1R3 (MYLK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.31
Assay: Binding constant for MYLK2 kinase domain
Drug: sunitinib
Target: Calcium/calmodulin-dependent protein kinase type II subunit gamma (Kinase)
Gene: CAMK2G
UniProt: Q13555 (KCC2G_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.36
Assay: Binding affinity to CAMK1G
Drug: sunitinib
Target: AP2-associated protein kinase 1 (Kinase)
Gene: AAK1
UniProt: Q2M2I8 (AAK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.96
Assay: Binding constant for AAK1 kinase domain
Drug: sunitinib
Target: Serine/threonine-protein kinase MARK2 (Kinase)
Gene: MARK2
UniProt: Q7KZI7 (MARK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.51
Assay: Binding constant for MARK2 kinase domain
Drug: sunitinib
Target: Hepatocyte growth factor receptor (Kinase)
Gene: MET
UniProt: P08581 (MET_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.92
Assay: Binding constant for MET(M1250T) kinase domain
Drug: sunitinib
Target: Tyrosine-protein kinase Lyn (Kinase)
Gene: LYN
UniProt: P07948 (LYN_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.57
Assay: Binding constant for LYN kinase domain
Drug: sunitinib
Target: Serine/threonine-protein kinase Nek2 (Kinase)
Gene: NEK2
UniProt: P51955 (NEK2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.3
Assay: Average Binding Constant for NEK2; NA=Not Active at 10 uM
Drug: sunitinib
Target: Ribosomal protein S6 kinase alpha-2 (Kinase)
Gene: RPS6KA2
UniProt: Q15349 (KS6A2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.77
Assay: Binding constant for RPS6KA2(Kin.Dom.1 - N-terminal) kinase domain
Drug: sunitinib
Target: 5'-AMP-activated protein kinase catalytic subunit alpha-1 (Kinase)
Gene: PRKAA1
UniProt: Q13131 (AAPK1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.72
Assay: Binding constant for AMPK-alpha1 kinase domain
Drug: sunitinib
Target: Calcium/calmodulin-dependent protein kinase type II subunit beta (Kinase)
Gene: CAMK2B
UniProt: Q13554 (KCC2B_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.85
Assay: Binding constant for CAMK2B kinase domain
Drug: sunitinib
Target: Fibroblast growth factor receptor 1 (Kinase)
Gene: FGFR1
UniProt: P11362 (FGFR1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.28
Assay: Binding constant for FGFR1 kinase domain
Drug: sunitinib
Target: Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform (Kinase)
Gene: PHKG1
UniProt: Q16816 (PHKG1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.26
Assay: Binding constant for full-length PHKG1
Drug: sunitinib
Target: Cyclin-dependent-like kinase 5 (Kinase)
Gene: CDK5
UniProt: Q00535 (CDK5_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.16
Assay: Binding constant for CDK5 kinase domain
Drug: sunitinib
Target: Calcium/calmodulin-dependent protein kinase type II subunit alpha (Kinase)
Gene: CAMK2A
UniProt: Q9UQM7 (KCC2A_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.1
Assay: Binding constant for CAMK2A kinase domain
Drug: sunitinib
Target: Serine/threonine-protein kinase 17B (Kinase)
Gene: STK17B
UniProt: O94768 (ST17B_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.96
Assay: Binding constant for full-length DRAK2
Drug: sunitinib
Target: Serine/threonine-protein kinase 10 (Kinase)
Gene: STK10
UniProt: O94804 (STK10_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.72
Assay: Binding constant for LOK kinase domain
Drug: sunitinib
Target: Tyrosine-protein kinase Fer (Kinase)
Gene: FER
UniProt: P16591 (FER_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.96
Assay: Binding constant for FER kinase domain
Drug: sunitinib
Target: Serine/threonine-protein kinase PLK4 (Kinase)
Gene: PLK4
UniProt: O00444 (PLK4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.72
Assay: Binding constant for PLK4 kinase domain
Drug: sunitinib
Target: Aurora kinase C (Kinase)
Gene: AURKC
UniProt: Q9UQB9 (AURKC_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.66
Assay: Binding constant for full-length AURKC
Drug: sunitinib
Target: Serine/threonine-protein kinase 16 (Kinase)
Gene: STK16
UniProt: O75716 (STK16_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.6
Assay: Binding constant for STK16 kinase domain
Drug: sunitinib
Target: Dual specificity protein kinase TTK (Kinase)
Gene: TTK
UniProt: P33981 (TTK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.2
Assay: Binding constant for TTK kinase domain
Drug: sunitinib
Target: Abelson tyrosine-protein kinase 2 (Kinase)
Gene: ABL2
UniProt: P42684 (ABL2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6
Assay: Binding constant for ABL2 kinase domain
Drug: sunitinib
Target: Ephrin type-A receptor 5 (Kinase)
Gene: EPHA5
UniProt: P54756 (EPHA5_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.92
Assay: Binding constant for EPHA5 kinase domain
Drug: sunitinib
Target: Fibroblast growth factor receptor 2 (Kinase)
Gene: FGFR2
UniProt: P21802 (FGFR2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.28
Assay: Average Binding Constant for FGFR2; NA=Not Active at 10 uM
Drug: sunitinib
Target: Serine/threonine-protein kinase N1 (Kinase)
Gene: PKN1
UniProt: Q16512 (PKN1_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.15
Assay: Binding constant for PKN1 kinase domain
Drug: sunitinib
Target: Protein kinase C theta type (Kinase)
Gene: PRKCQ
UniProt: Q04759 (KPCT_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.37
Assay: Binding constant for PRKCQ kinase domain
Drug: sunitinib
Target: Serine/threonine-protein kinase 17A (Kinase)
Gene: STK17A
UniProt: Q9UEE5 (ST17A_HUMAN)
Organism: Homo sapiens
Activity: Kd = 9
Assay: Binding constant for DRAK1 kinase domain
Drug: sunitinib
Target: Ephrin type-A receptor 6 (Kinase)
Gene: EPHA6
UniProt: Q9UF33 (EPHA6_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.02
Assay: Binding constant for EPHA6 kinase domain
Drug: sunitinib
Target: TRAF2 and NCK-interacting protein kinase (Kinase)
Gene: TNIK
UniProt: Q9UKE5 (TNIK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.6
Assay: Average Binding Constant for TNIK; NA=Not Active at 10 uM
Drug: sunitinib
Target: Casein kinase I isoform epsilon (Kinase)
Gene: CSNK1E
UniProt: P49674 (KC1E_HUMAN)
Organism: Homo sapiens
Activity: Kd = 7.89
Assay: Binding constant for full-length CSNK1E
Drug: sunitinib
Target: Tyrosine-protein kinase Fgr (Kinase)
Gene: FGR
UniProt: P09769 (FGR_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.57
Assay: Binding constant for FGR kinase domain
Drug: sunitinib
Target: Aurora kinase A (Kinase)
Gene: AURKA
UniProt: O14965 (AURKA_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.77
Assay: Binding constant for AURKA kinase domain
Drug: sunitinib
Target: ALK tyrosine kinase receptor (Kinase)
Gene: ALK
UniProt: Q9UM73 (ALK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.77
Assay: Binding constant for ALK kinase domain
Drug: sunitinib
Target: Ephrin type-A receptor 3 (Kinase)
Gene: EPHA3
UniProt: P29320 (EPHA3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.68
Assay: Binding constant for EPHA3 kinase domain
Drug: sunitinib
Target: BMP-2-inducible protein kinase (Kinase)
Gene: BMP2K
UniProt: Q9NSY1 (BMP2K_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.26
Assay: Binding constant for BIKE kinase domain
Drug: sunitinib
Target: Serine/threonine-protein kinase pim-2 (Kinase)
Gene: PIM2
UniProt: Q9P1W9 (PIM2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.3
Assay: Average Binding Constant for PIM2; NA=Not Active at 10 uM
Drug: sunitinib
Target: Tyrosine-protein kinase FRK (Kinase)
Gene: FRK
UniProt: P42685 (FRK_HUMAN)
Organism: Homo sapiens
Activity: Kd = 6.28
Assay: Binding constant for FRK kinase domain