AIM-Harvard/TrialPanorama-filtered huggingface dataset:
Drug: astemizole
Target: Beta-3 adrenergic receptor (GPCR)
Gene: ADRB3
UniProt: P13945 (ADRB3_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.219
Assay: DRUGMATRIX: Adrenergic beta3 radioligand binding (ligand: [125I] Cyanopindolol)
Drug: astemizole
Target: Alpha-2C adrenergic receptor (GPCR)
Gene: ADRA2C
UniProt: P18825 (ADA2C_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.545
Assay: DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
Drug: astemizole
Target: Sodium-dependent dopamine transporter (Transporter)
Gene: SLC6A3
UniProt: Q01959 (SC6A3_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.101
Assay: DRUGMATRIX: Dopamine Transporter radioligand binding (ligand: [125I] RTI-55)
Drug: astemizole
Target: Adenosine receptor A3 (GPCR)
Gene: ADORA3
UniProt: P0DMS8 (AA3R_HUMAN)
Organism: Homo sapiens
Activity: Ki = 4.784
Assay: DRUGMATRIX: Adenosine A3 radioligand binding (ligand: AB-MECA)
Drug: astemizole
Target: D(4) dopamine receptor (GPCR)
Gene: DRD4
UniProt: P21917 (DRD4_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.671
Assay: DRUGMATRIX: Dopamine D4.2 radioligand binding (ligand: [3H] Spiperone)
Drug: astemizole
Target: Alpha-1D adrenergic receptor (GPCR)
Gene: ADRA1D
UniProt: P25100 (ADA1D_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.004
Assay: DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug: astemizole
Target: 5-hydroxytryptamine receptor 3A (Ion channel)
Gene: HTR3A
UniProt: P46098 (5HT3A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.018
Assay: DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT3 radioligand binding (ligand: [3H] GR-65630)
Drug: astemizole
Target: Kappa-type opioid receptor (GPCR)
Gene: OPRK1
UniProt: P41145 (OPRK_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.577
Assay: DRUGMATRIX: Opiate kappa (OP2, KOP) radioligand binding (ligand: [3H] Diprenorphine)
Drug: astemizole
Target: ATP-binding cassette sub-family G member 2 (Transporter)
Gene: ABCG2
UniProt: Q9UNQ0 (ABCG2_HUMAN)
Organism: Homo sapiens
Drug: astemizole
Target: Glycine receptor subunit alpha-1 (Ion channel)
Gene: GLRA1
UniProt: P23415 (GLRA1_HUMAN)
Organism: Homo sapiens
Activity: EC50 = 5.38
Drug: astemizole
Target: Calmodulin (Cytosolic other)
Gene: CALM1|CALM2|CALM3
UniProt: P0DP23|P0DP24|P0DP25 (CALM1_HUMAN|CALM2_HUMAN|CALM3_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6
Drug: astemizole
Target: Delta-type opioid receptor (GPCR)
Gene: OPRD1
UniProt: P41143 (OPRD_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.34
Assay: DRUGMATRIX: Opiate delta1 (OP1, DOP) radioligand binding (ligand: [3H] Naltrindole)
Drug: astemizole
Target: Somatostatin receptor type 5 (GPCR)
Gene: SSTR5
UniProt: P35346 (SSR5_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.39
Assay: Displacement of [125I]11-Tyr somatostatin-14 from human SST5R expressed in CHO cells
Drug: astemizole
Target: Epidermal growth factor receptor (Kinase)
Gene: EGFR
UniProt: P00533 (EGFR_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.218
Assay: DRUGMATRIX: Protein Tyrosine Kinase, EGF Receptor enzyme inhibition (substrate: Poly(Glu:Tyr))
Drug: astemizole
Target: Substance-P receptor (GPCR)
Gene: TACR1
UniProt: P25103 (NK1R_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.065
Assay: DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
Drug: astemizole
Target: Tyrosine-protein kinase Lck (Kinase)
Gene: LCK
UniProt: P06239 (LCK_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.701
Assay: DRUGMATRIX: Protein Tyrosine Kinase, LCK enzyme inhibition (substrate: Poly(Glu:Tyr))
Drug: astemizole
Target: Tyrosine-protein kinase Fyn (Kinase)
Gene: FYN
UniProt: P06241 (FYN_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.546
Assay: DRUGMATRIX: Protein Tyrosine Kinase, Fyn enzyme inhibition (substrate: Poly(Glu:Tyr))
Drug: astemizole
Target: Receptor tyrosine-protein kinase erbB-2 (Kinase)
Gene: ERBB2
UniProt: P04626 (ERBB2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.883
Assay: DRUGMATRIX: Protein Tyrosine Kinase, ERBB2 (HER2) enzyme inhibition (substrate: Poly(Glu:Tyr))
Drug: astemizole
Target: Substance-K receptor (GPCR)
Gene: TACR2
UniProt: P21452 (NK2R_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.002
Assay: DRUGMATRIX: Tachykinin NK2  radioligand binding (ligand: [3H] SR-48968)
Drug: astemizole
Target: Potassium voltage-gated channel subfamily H member 1 (Ion channel)
Gene: KCNH1
UniProt: O95259 (KCNH1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 6.7
Action type: BLOCKER
Drug: astemizole
Target: Alpha-1B adrenergic receptor (GPCR)
Gene: Adra1b
UniProt: P15823 (ADA1B_RAT)
Organism: Rattus norvegicus
Activity: Ki = 7.022
Assay: DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
Drug: astemizole
Target: 5-hydroxytryptamine receptor 1B (GPCR)
Gene: Htr1b
UniProt: P28564 (5HT1B_RAT)
Organism: Rattus norvegicus
Activity: Ki = 6.201
Assay: DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)
Drug: astemizole
Target: Melanocortin receptor 4 (GPCR)
Gene: MC4R
UniProt: P32245 (MC4R_HUMAN)
Organism: Homo sapiens
Activity: Ki = 4.87
Assay: DRUGMATRIX: Melanocortin MC4 radioligand binding (ligand: [125I] NDP-alpha-MSH)
Drug: astemizole
Target: Melanocortin receptor 5 (GPCR)
Gene: MC5R
UniProt: P33032 (MC5R_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.673
Assay: DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)
Drug: astemizole
Target: Melanocortin receptor 3 (GPCR)
Gene: MC3R
UniProt: P41968 (MC3R_HUMAN)
Organism: Homo sapiens
Activity: Ki = 4.868
Assay: DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)
Drug: astemizole
Target: Membrane-associated progesterone receptor component 1 (Membrane receptor)
Gene: Pgrmc1
UniProt: P70580 (PGRC1_RAT)
Organism: Rattus norvegicus
Activity: Ki = 6.733
Assay: DRUGMATRIX: Sigma2 radioligand binding (ligand: [3H] Ifenprodil)
Drug: astemizole
Target: Alpha-1A adrenergic receptor (GPCR)
Gene: Adra1a
UniProt: P43140 (ADA1A_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 7.62
Drug: astemizole
Target: 5-hydroxytryptamine receptor 1A (GPCR)
Gene: Htr1a
UniProt: P19327 (5HT1A_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 6.12
Drug: astemizole
Target: Multidrug and toxin extrusion protein 1 (Transporter)
Gene: SLC47A1
UniProt: Q96FL8 (S47A1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.58
Assay: Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay
Drug: astemizole
Target: Protein farnesyltransferase (Enzyme)
Gene: FNTA|FNTB
UniProt: P29702|P49355 (FNTA_BOVIN|FNTB_BOVIN)
Organism: Bos taurus
Activity: IC50 = 8.7
Assay: Inhibit of purified bovine Farnesyl protein transferase.
Drug: astemizole
Target: Polycomb protein EED (Unclassified)
Gene: EED
UniProt: O75530 (EED_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.03
Drug: astemizole
Target: HLA class I histocompatibility antigen, A-3 alpha chain (Unclassified)
Gene: HLA-A
UniProt: P04439 (1A03_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.6
Assay: Binding affinity to human biotinylated HLA-A2 by surface plasmon resonance assay
Drug: astemizole
Target: Transmembrane protein 97 (Enzyme)
Gene: TMEM97
UniProt: Q5BJF2 (TMM97_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.02
Assay: Displacement of [3H]-DTG from the Sigma2 receptor
Drug: astemizole
Target: Histamine H1 receptor (GPCR)
Gene: HRH1
UniProt: P35367 (HRH1_HUMAN)
Organism: Homo sapiens
Activity: A2 = 8.58
Action type: ANTAGONIST
Drug: asulacrine
Target: DNA topoisomerase 2-alpha (Enzyme)
Gene: TOP2A
UniProt: P11388 (TOP2A_HUMAN)
Organism: Homo sapiens
Drug: atazanavir
Target: Cytochrome P450 3A4 (Enzyme)
Gene: CYP3A4
UniProt: P08684 (CP3A4_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.629
Drug: atazanavir
Target: Multidrug resistance protein 1 (Transporter)
Gene: ABCB1
UniProt: P08183 (MDR1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.17
Assay: Inhibition of human MDR1-dependent accumulation of calcein-AM expressed in MDCK2 cells
Drug: atazanavir
Target: Cytochrome P450 2C9 (Enzyme)
Gene: CYP2C9
UniProt: P11712 (CP2C9_HUMAN)
Organism: Homo sapiens
Activity: Ki = 4.921
Drug: atazanavir
Target: Cytochrome P450 1A2 (Enzyme)
Gene: CYP1A2
UniProt: P05177 (CP1A2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 4.921
Drug: atazanavir
Target: Gag-Pol polyprotein (Polyprotein)
Gene: gag-pol
UniProt: P03367 (POL_HV1BR)
Organism: Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI)
Activity: Ki = 8.575
Drug: atazanavir
Target: Pol polyprotein (Enzyme)
Gene: pol
UniProt: Q72874 (Q72874_9HIV1)
Organism: Human immunodeficiency virus 1
Activity: Ki = 9.62
Action type: INHIBITOR
Assay: Inhibition constant for human immunodeficiency virus type 1 protease
Drug: atazanavir
Target: Reverse transcriptase/RNaseH (Enzyme)
Gene: pol
UniProt: Q72547 (Q72547_9HIV1)
Organism: Human immunodeficiency virus 1
Activity: IC50 = 7.59
Assay: The percent reduction of the reverse transcriptase (RT) activity in HIV-1/MN-infected MT-2 cells.
Drug: atazanavir
Target: UDP-glucuronosyltransferase 1-1 (Enzyme)
Gene: UGT1A1
UniProt: P22309 (UD11_HUMAN)
Organism: Homo sapiens
Activity: Ki = 5.721
Drug: atazanavir
Target: Protease (Enzyme)
Gene: protease
UniProt: Q9YQ12 (Q9YQ12_9HIV1)
Organism: Human immunodeficiency virus 1
Activity: IC50 = 8.4
Assay: Inhibition of wild type C-South African Human immunodeficiency virus 1 protease using chromogenic peptide H-1048 as substrate by UV spectrophotometric analysis
Drug: atazanavir
Target: Protease (Unclassified)
Gene: HIV-1 protease
UniProt: O90781 (O90781_9PLVG)
Organism: Human immunodeficiency virus
Activity: Ki = 10.27
Assay: Inhibition of HIV1 recombinant protease L10F/L19I/K20R/L33F/E35D/M36I/R41K/F53L/I54V/L63P/H69K/A71V/T74P/I84V/L89M/L90M/I93L mutant expressed in Escherichia coli by spectrophotometric assay
Drug: atazanavir
Target: Protease (Unclassified)
Gene: HIV-1 protease
UniProt: Q9YQ30 (Q9YQ30_9PLVG)
Organism: Human immunodeficiency virus
Activity: Ki = 10.12
Assay: Inhibition of HIV1 recombinant protease L10I/I15V/E35D/N37S/R41K/I62V/L63P/A71V/G73S/L90M mutant expressed in Escherichia coli by spectrophotometric assay
Drug: atenolol
Target: Beta-1 adrenergic receptor (GPCR)
Gene: ADRB1
UniProt: P08588 (ADRB1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 7.3
Action type: ANTAGONIST
Drug: atenolol
Target: Beta-2 adrenergic receptor (GPCR)
Gene: ADRB2
UniProt: P07550 (ADRB2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.8
Drug: atenolol
Target: Adenosine receptor A3 (GPCR)
Gene: ADORA3
UniProt: P0DMS8 (AA3R_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 8.75
Assay: Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
Drug: atenolol
Target: 5-hydroxytryptamine receptor 1A (GPCR)
Gene: Htr1a
UniProt: P19327 (5HT1A_RAT)
Organism: Rattus norvegicus
Activity: Ki = 5
Drug: atenolol
Target: Beta-2 adrenergic receptor (GPCR)
Gene: Adrb2
UniProt: Q8K4Z4 (ADRB2_CAVPO)
Organism: Cavia porcellus
Activity: Kd = 5.93
Assay: In vitro beta-2 adrenergic receptor activity was determined by measuring inhibition of the isoproterenol induced relaxation in isolated guinea pig tracheal chains contracted with PGF2-alpha
Drug: atenolol
Target: Beta-1 adrenergic receptor (GPCR)
Gene: ADRB1
UniProt: B0FL73 (B0FL73_CAVPO)
Organism: Cavia porcellus
Activity: Kd = 7.62
Assay: In vitro beta-1 adrenergic receptor activity was determined via inhibition of the positive chronotropic actions of isoproterenol in isolated guinea pig atrial preparations
Drug: atomoxetine
Target: Potassium voltage-gated channel subfamily H member 2 (Ion channel)
Gene: KCNH2
UniProt: Q12809 (KCNH2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.68
Assay: Inhibition of human ERG expressed in HEK293 cells by patch-clamp method
Drug: atomoxetine
Target: Sodium-dependent serotonin transporter (Transporter)
Gene: SLC6A4
UniProt: P31645 (SC6A4_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.05
Assay: Equilibrium dissociation constant (KD) for Competitive binding between [3H]- imipramine and the compound at human transporter-hSERT
Drug: atomoxetine
Target: Sodium-dependent noradrenaline transporter (Transporter)
Gene: SLC6A2
UniProt: P23975 (SC6A2_HUMAN)
Organism: Homo sapiens
Activity: Kd = 8.69
Action type: INHIBITOR
Assay: Equilibrium dissociation constant (KD) for Competitive binding between [3H]- nisoxatine and the compound at human Norepinephrine transporter
Drug: atomoxetine
Target: Sodium-dependent dopamine transporter (Transporter)
Gene: SLC6A3
UniProt: Q01959 (SC6A3_HUMAN)
Organism: Homo sapiens
Activity: Kd = 5.97
Assay: Equilibrium dissociation constant (KD) for Competitive binding between [3H]WIN-35428 and the compound at human transporter-hDAT
Drug: atomoxetine
Target: Cytochrome P450 2D6 (Enzyme)
Gene: CYP2D6
UniProt: P10635 (CP2D6_HUMAN)
Organism: Homo sapiens
Activity: Ki = 4.77
Drug: atomoxetine
Target: G protein-activated inward rectifier potassium channel 2 (Ion channel)
Gene: KCNJ6
UniProt: P48051 (KCNJ6_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.282
Drug: atomoxetine
Target: Sodium-dependent serotonin transporter (Transporter)
Gene: Slc6a4
UniProt: P31652 (SC6A4_RAT)
Organism: Rattus norvegicus
Activity: Ki = 7.37
Assay: Inhibition of [3H]5-HT reuptake into rat frontal cortex synaptosomes
Drug: atomoxetine
Target: Sodium-dependent dopamine transporter (Transporter)
Gene: Slc6a3
UniProt: P23977 (SC6A3_RAT)
Organism: Rattus norvegicus
Activity: Ki = 5.85
Assay: Inhibition of [3H]- DA reuptake into rat striatal synaptosomes
Drug: atomoxetine
Target: Transporter (Transporter)
Gene: Slc6a2
UniProt: Q9WTR4 (Q9WTR4_RAT)
Organism: Rattus norvegicus
Activity: Ki = 9.15
Assay: Inhibition of [3H]- NE reuptake into rat hippocampal synaptosomes
Drug: atomoxetine
Target: Transporter (Transporter)
Gene: NET
UniProt: Q63380 (Q63380_RAT)
Organism: Rattus norvegicus
Activity: Ki = 8.4
Assay: Displacement of [3H]nisoxetine from Sprague-dawley rat NET by liquid scintillation spectrophotometry
Drug: atomoxetine
Target: Kir3.1/Kir3.2 (Ion channel)
Gene: KCNJ6|KCNJ3
UniProt: P48051|P48549 (KCNJ6_HUMAN|KCNJ3_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.478
Drug: atomoxetine
Target: Kir3.1/Kir3.4 (Ion channel)
Gene: KCNJ5|KCNJ3
UniProt: P48544|P48549 (KCNJ5_HUMAN|KCNJ3_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.845
Drug: atomoxetine
Target: Krueppel-like factor 10 (Nuclear other)
Gene: KLF10
UniProt: Q13118 (KLF10_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4
Drug: atorvastatin
Target: Nuclear receptor subfamily 1 group I member 3 (Nuclear hormone receptor)
Gene: NR1I3
UniProt: Q14994 (NR1I3_HUMAN)
Organism: Homo sapiens
Drug: atorvastatin
Target: Cytochrome P450 3A4 (Enzyme)
Gene: CYP3A4
UniProt: P08684 (CP3A4_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.29
Assay: Inhibition of CYP3A4 in human liver microsome
Drug: atorvastatin
Target: 3-hydroxy-3-methylglutaryl-coenzyme A reductase (Enzyme)
Gene: HMGCR
UniProt: P04035 (HMDH_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 8
Action type: INHIBITOR
Drug: atorvastatin
Target: Histone deacetylase 2 (Enzyme)
Gene: HDAC2
UniProt: Q92769 (HDAC2_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.65
Assay: Inhibition of recombinant HDAC2 (unknown origin) after 10 mins by fluorimetric analysis
Drug: atorvastatin
Target: Histone deacetylase 1 (Enzyme)
Gene: HDAC1
UniProt: Q13547 (HDAC1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.93
Assay: Inhibition of recombinant HDAC1 (unknown origin) after 10 mins by fluorimetric analysis
Drug: atorvastatin
Target: Histone deacetylase 6 (Enzyme)
Gene: HDAC6
UniProt: Q9UBN7 (HDAC6_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.84
Assay: Inhibition of recombinant HDAC6 (unknown origin) after 10 mins by fluorimetric analysis
Drug: atorvastatin
Target: 3-hydroxy-3-methylglutaryl-coenzyme A reductase (Enzyme)
Gene: Hmgcr
UniProt: P51639 (HMDH_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 8.42
Assay: Inhibition of rat microsomal HMGCoA reductase
Drug: atorvastatin
Target: 3-hydroxy-3-methylglutaryl-coenzyme A reductase (Enzyme)
Gene: HMGCR
UniProt: Q1W675 (HMDH_PIG)
Organism: Sus scrofa
Activity: IC50 = 4.49
Drug: atovaquone
Target: Dihydroorotate dehydrogenase (quinone), mitochondrial (Enzyme)
Gene: DHODH
UniProt: Q02127 (PYRD_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 5.03
Drug: atovaquone
Target: Ubiquinol-cytochrome-c reductase complex core protein I, mitochondrial (Enzyme)
UniProt: P43264 (QCR1_EUGGR)
Organism: Euglena gracilis
Drug: atovaquone
Target: Cytochrome b (Enzyme)
Gene: MT-CYB
UniProt: Q02768 (CYB_PLAFA)
Organism: Plasmodium falciparum
Action type: INHIBITOR
Assay: Mechanism of Action; CHEMBL1777; SINGLE PROTEIN
Drug: atovaquone
Target: Dihydroorotate dehydrogenase (quinone), mitochondrial (Enzyme)
Gene: Dhodh
UniProt: Q63707 (PYRD_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 6.15
Assay: Inhibition of rat purified recombinant DHODH
Drug: atovaquone
Target: Dihydroorotate dehydrogenase (Enzyme)
Gene: dhod
UniProt: Q54A96 (Q54A96_PLAFA)
Organism: Plasmodium falciparum
Activity: Ki = 4.57
Assay: Inhibition of plasmodium falciparum DHODH assessed as inhibition of [14C]bicarbonate incorporation into pyrimidine nucleotide by HPLC analysis
Drug: atracurium
Target: Neuronal acetylcholine receptor subunit alpha-2 (Ion channel)
Gene: CHRNA2
UniProt: Q15822 (ACHA2_HUMAN)
Organism: Homo sapiens
Drug: atracurium
Target: Neuronal acetylcholine receptor subunit alpha-7 (Ion channel)
Gene: CHRNA7
UniProt: P36544 (ACHA7_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 8.25
Action type: ANTAGONIST
Assay: Antagonism of ACh activation of human &alpha7 nACh receptors expressed in <i>Xenopus</i> oocytes, at different ACh concentrations.
Drug: atracurium
Target: Small conductance calcium-activated potassium channel protein 3 (Ion channel)
Gene: Kcnn3
UniProt: P70605 (KCNN3_RAT)
Organism: Rattus norvegicus
Activity: Ki = 5.23
Assay: Displacement of [I125]apamine from Wistar rat recombinant SK3 channel expressed in HEK293 cells
Drug: atracurium
Target: Acetylcholine receptor (Ion channel)
Gene: CHRNA1|CHRNB1|CHRND
UniProt: P02708|P11230|Q07001 (ACHA_HUMAN|ACHB_HUMAN|ACHD_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 7.77
Action type: ANTAGONIST
Drug: atracurium
Target: Neuronal acetylcholine receptor subunit alpha-3 (Ion channel)
Gene: CHRNA3
UniProt: P32297 (ACHA3_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 9.05
Action type: ANTAGONIST
Assay: Antagonism of ACh activation of human &alpha3&beta2 or &alpha3&beta4 nACh receptors expressed in <i>Xenopus</i> oocytes, at different ACh concentrations.
Drug: atracurium
Target: Neuronal acetylcholine receptor subunit alpha-4 (Ion channel)
Gene: CHRNA4
UniProt: P43681 (ACHA4_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 8.1
Action type: ANTAGONIST
Assay: Antagonism of ACh activation of human &alpha4&beta2 nACh receptors expressed in <i>Xenopus</i> oocytes, at different ACh concentrations.
Drug: atropine
Target: Alpha-2A adrenergic receptor (GPCR)
Gene: ADRA2A
UniProt: P08913 (ADA2A_HUMAN)
Organism: Homo sapiens
Activity: Ki = 4.85
Action type: ANTAGONIST
Drug: atropine
Target: 5-hydroxytryptamine receptor 2A (GPCR)
Gene: HTR2A
UniProt: P28223 (5HT2A_HUMAN)
Organism: Homo sapiens
Activity: Ki  5.155
Drug: atropine
Target: 5-hydroxytryptamine receptor 2C (GPCR)
Gene: HTR2C
UniProt: P28335 (5HT2C_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.276
Assay: DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine)
Drug: atropine
Target: Histamine H1 receptor (GPCR)
Gene: HRH1
UniProt: P35367 (HRH1_HUMAN)
Organism: Homo sapiens
Activity: Ki  5.907
Drug: atropine
Target: Muscarinic acetylcholine receptor M1 (GPCR)
Gene: CHRM1
UniProt: P11229 (ACM1_HUMAN)
Organism: Homo sapiens
Activity: Ki = 9.31
Action type: ANTAGONIST
Drug: atropine
Target: Muscarinic acetylcholine receptor M2 (GPCR)
Gene: CHRM2
UniProt: P08172 (ACM2_HUMAN)
Organism: Homo sapiens
Activity: Ki = 8.97
Action type: ANTAGONIST
Drug: atropine
Target: Muscarinic acetylcholine receptor M3 (GPCR)
Gene: CHRM3
UniProt: P20309 (ACM3_HUMAN)
Organism: Homo sapiens
Activity: Ki = 9.5
Action type: ANTAGONIST
Drug: atropine
Target: Muscarinic acetylcholine receptor M4 (GPCR)
Gene: CHRM4
UniProt: P08173 (ACM4_HUMAN)
Organism: Homo sapiens
Activity: Ki = 9.39
Drug: atropine
Target: Muscarinic acetylcholine receptor M5 (GPCR)
Gene: CHRM5
UniProt: P08912 (ACM5_HUMAN)
Organism: Homo sapiens
Activity: Ki = 9.29
Drug: atropine
Target: Alpha-1D adrenergic receptor (GPCR)
Gene: ADRA1D
UniProt: P25100 (ADA1D_HUMAN)
Organism: Homo sapiens
Activity: Ki = 6.177
Assay: DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug: atropine
Target: Solute carrier family 22 member 1 (Transporter)
Gene: SLC22A1
UniProt: O15245 (S22A1_HUMAN)
Organism: Homo sapiens
Activity: IC50 = 4.91
Assay: Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells by confocal microscopy
Drug: atropine
Target: Muscarinic acetylcholine receptor M2 (GPCR)
Gene: Chrm2
UniProt: P10980 (ACM2_RAT)
Organism: Rattus norvegicus
Activity: Ki = 9.15
Assay: Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium
Drug: atropine
Target: Muscarinic acetylcholine receptor M1 (GPCR)
Gene: Chrm1
UniProt: P08482 (ACM1_RAT)
Organism: Rattus norvegicus
Activity: Ki = 9.59
Assay: Ability to displace [3H]pirenzepine (PZ) from M1 receptor in rat cortex homogenate
Drug: atropine
Target: Acetylcholinesterase (Enzyme)
Gene: Ache
UniProt: P21836 (ACES_MOUSE)
Organism: Mus musculus
Activity: Ki = 9.46
Assay: Compound was evaluated for the binding affinity by displacing [3H]oxotremorine from mouse cerebral cortex tissue.
Drug: atropine
Target: Muscarinic acetylcholine receptor M2 (GPCR)
Gene: Chrm2
UniProt: Q9ERZ4 (ACM2_MOUSE)
Organism: Mus musculus
Activity: Ki = 9.46
Assay: Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex
Drug: atropine
Target: Muscarinic acetylcholine receptor M3 (GPCR)
Gene: Chrm3
UniProt: P08483 (ACM3_RAT)
Organism: Rattus norvegicus
Activity: Ki = 9.92
Assay: Ability to displace [3H]N-methylscopolamine (NMS) from M3 receptor in rat submaxillary gland homogenate
Drug: atropine
Target: Muscarinic receptor M1 (GPCR)
UniProt: Q8WMX0 (Q8WMX0_BOVIN)
Organism: Bos taurus
Activity: Ki = 9.7
Assay: Binding affinity against Muscarinic acetylcholine receptor M1 by displacement of [3H]pirenzepine in bovine striatum
Drug: atropine
Target: Muscarinic acetylcholine receptor M5 (GPCR)
Gene: Chrm5
UniProt: P08911 (ACM5_RAT)
Organism: Rattus norvegicus
Activity: Ki = 9.07
Assay: Displacement of [3H]NMS from rat recombinant muscarinic M5 receptor expressed in CHO cells after 2 hrs by microplate scintillation counting
Drug: atropine
Target: Muscarinic acetylcholine receptor M4 (GPCR)
Gene: Chrm4
UniProt: P08485 (ACM4_RAT)
Organism: Rattus norvegicus
Activity: Ki = 9.28
Assay: Displacement of [3H]NMS from rat recombinant muscarinic M4 receptor expressed in CHO cells after 2 hrs by microplate scintillation counting
Drug: atropine
Target: Muscarinic acetylcholine receptor (GPCR)
Gene: GPM3
UniProt: Q8VH26 (Q8VH26_CAVPO)
Organism: Cavia porcellus
Activity: Kd = 8.99
Assay: Antagonist activity at muscarinic M3 receptor in guinea-pig ileum assessed as inhibition of carbachol-induced contractions after 15 mins
Drug: atropine
Target: Nicotinic acetylcholine receptor alpha 5 subunit (Ion channel)
Gene: nAChRalpha5
UniProt: A9XFY4 (A9XFY4_MUSDO)
Organism: Musca domestica
Activity: Ki = 4.49
Assay: Displacement of [3H]alpha-bungarotoxin from nAChR in Musca domestica (house fly) head membrane after 60 min by scintillation counting
Drug: atropine
Target: Muscarinic acetylcholine receptor (GPCR)
Gene: Chrm1|Chrm3|Chrm4|Chrm5|Chrm2
UniProt: P08482|P08483|P08485|P08911|P10980 (ACM1_RAT|ACM3_RAT|ACM4_RAT|ACM5_RAT|ACM2_RAT)
Organism: Rattus norvegicus
Activity: Ki = 9.52
Assay: The compound was tested for inhibition of [3H]NMS binding against muscarinic acetylcholine receptor in rat brain
Drug: azapetine
Target: Adrenergic receptor alpha-2 (GPCR)
Gene: Adra2b|Adra2c|Adra2a
UniProt: P19328|P22086|P22909 (ADA2B_RAT|ADA2C_RAT|ADA2A_RAT)
Organism: Rattus norvegicus
Activity: IC50 = 5.89
Assay: Inhibition of specific [3H]clonidine binding (0.4 nM) to rat brain membranes alpha-2 adrenergic receptor