AIM-Harvard/TrialPanorama-filtered huggingface dataset:
Study NCT05416372 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Religious Engagement in Health Intervention
Description: Religious Engagement in Health Intervention for blood pressure (BP) includes three evidence-based components: (1) educational sessions for Christian and Muslim leaders on religious teachings and medical aspects of BP, (2) equipping religious leaders to provide BP teaching in their communities using knowledge learned from educational sessions and through longitudinal mentorship meetings, and (3) community BP screening organized by religious leaders in partnership with local health care workers, and referrals for clinical care as needed.
Study NCT06025695 — intervention group
Intervention type: COMBINATION_PRODUCT
Group type: ACTIVE_COMPARATOR
Intervention: GSK's liquid oral live attenuated HRV
Description: 2 doses of GSK's liquid oral live attenuated HRV study intervention administered orally at Day 1 and Month 1, according to the immunization schedule for HRV study intervention licensed outside of China.
Study NCT05238844 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ATI-2173 25mg
Description: ATI-2173 is a liver-targeted phosphoramidate prodrug of clevudine designed to enhance anti-HBV activity while decreasing systemic exposure to clevudine. It will be dosed as a capsule by mouth.
Study NCT05238844 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Vebicorvir 300mg
Description: Vebicorvir (formerly ABI-H0731) is an orally administered, potent and selective small molecule inhibitor of the HBV core protein
Study NCT05238844 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Viread 300Mg Tablet
Description: Viread is a nucleotide analogue reverse transcriptase inhibitor used for chronic hepatitis B virus.
Study NCT05238844 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Viread 300Mg Tablet
Description: Viread is a nucleotide analogue reverse transcriptase inhibitor used for chronic hepatitis B virus.
Study NCT05973240 — intervention group
Intervention type: OTHER
Intervention: Participation in an web-based survey
Description: Patients who agree to participate will access a web-based survey (SurveyMonkey) via social media, mobile messages, or emails. The invitation will provide study details, eligibility criteria, and tasks. Patients will confirm inclusion/exclusion criteria upon access, and those ineligible will opt out. Data collection will take approximately 10 minutes per patient. Collected data will be sent to an electronic data collector and saved as an eCRF file in REDCap. The study will conduct two cross-sectional data collection rounds using web surveys to ensure anonymity. Convenience sampling will target anticoagulated patient associations' webpages and social media (e.g., Feder-AIPA, AICCA). In the second round, participants will be informed not to resubmit if they have already completed the survey to avoid overlapping responses.
Study NCT05547594 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Multimodal surgical prehabilitation
Description: Participants will be encouraged to engage in regular physical activity (endurance and resistance exercise), eat healthily and undergo cognitive behavioural therapy (the latter only if required) during the weeks prior to surgery.
Study NCT04835389 — intervention group
Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: AlloGen Liquid
Description: Amniotic fluid
Study NCT04835389 — intervention group
Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: 0.9% normal saline
Study NCT05736653 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Task-specific PCMS
Description: 120 pairs of TMS and PNS volleys will be administered during electromyography-triggered functional electrical stimulation (FES)-assisted task-specific training (task-specific PCMS). In the task-specific PCMS, participants will first grasp a spherical ball when prompted by an auditory 'Ready' cue, and upon seeing a visual 'Go' cue will voluntarily extend the wrist and fingers to release the ball. After the 'Go cue', our customized stimulation delivery algorithm triggers the TMS and PNS only when the extensor digitorum communis (EDC) muscle activity exceeds a pre-determined threshold. The algorithm will then trigger FES to EDC after detecting EDC activity (\~2 ms after PNS) for the next 2 seconds, allowing the pairing of PCMS (TMS and PNS) with the voluntary movement of EDC without the confounding effects of FES.
Study NCT05086991 — intervention group
Intervention type: OTHER
Intervention: Follow up
Description: like group descriptions
Study NCT05616052 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Semaglutide
Description: treatment with different dosage regimes
Study NCT05736653 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Task-specific sham-PCMS
Description: 120 pairs of sham-PCMS stimuli will be administered during task-specific practice. The TMS coil will be placed \~10 cm behind the participant's head, and PNS electrodes will be placed in the same position as for task-specific PCMS, but no stimulation will be delivered. Like the task-specific PCMS condition, participants will perform the same grasp and release a ball task in an identical manner. FES will be delivered after detecting voluntary EDC activity, similar to the task-specific PCMS condition.
Study NCT05736653 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: PCMS-rest
Description: 120 pairs of TMS and PNS volleys will be administered with the EDC muscle at rest every 10 s (\~20 min, 0.1 Hz). TMS will be used to elicit motor-evoked potentials (MEPs). Antidromic activation of spinal motor neurons will be elicited by supramaximal peripheral nerve stimulation (PNS) applied to the radial nerve near the elbow. Volleys will be timed to arrive in the spinal cord based on central and peripheral conduction times calculated for each subject so that the pre-synaptic terminal is depolarized via TMS \~1-2 ms before spinal motor neurons are depolarized via PNS at a pulse duration of 200us. We will also perform stimulation of the cervical roots (C-root) by placing the coil behind the neck and stimulating the C-root (C6 and C7 vertebrae), which innervate the finger extensor muscles. Conduction times will be calculated from latencies of the primary motor area (M1) MEP, C-root, and M-wave.
Study NCT01353066 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Intensive Medical Treatment
Study NCT01353066 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: IMM+Roux-en-Y Gastric Bypass (RYGBP)
Study NCT05569356 — intervention group
Intervention type: BIOLOGICAL
Intervention: Prospective
Description: -Additional blood samples -Myocarditis biopsy sample (routine care) -Additional pericardial fluid sample (routine care)
Study NCT05569356 — intervention group
Intervention type: OTHER
Intervention: Retrospective
Description: None (only data collection)
Study NCT05705687 — intervention group
Intervention type: DRUG
Group type: OTHER
Intervention: BEP Protocol
Description: anticancer therapy
Study NCT05705687 — intervention group
Intervention type: DRUG
Group type: OTHER
Intervention: Dose-dense regimen
Description: T-BEP-Oxaliplatin followed by Cisplatin - Ifosfamide - Paclitaxel
Study NCT05705687 — intervention group
Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Early tumor resection or HD-CT
Description: TIP protocol + early surgery or high-dose chemotherapy if surgery not feasible or metastatic disease
Study NCT05131035 — intervention group
Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: SCORES (Specific COgnitive Remediation with Support)
Description: This study evaluates the effectiveness of a 10-week cognitive remediation program plus group coaching and therapy to improve processing speed and, in turn, social functioning and attenuated positive symptoms in CHR subjects. The SCORES (Specific COgnitive Remediation with Support) intervention is a novel CR program combined with group coaching, performance-based rewards, game-like tasks, and therapy elements to increase engagement and retention.~In the 2 year, R61 phase, all participants will complete 40 hours of CR (4 hrs per week) with a mid-point assessment (20 hours of CR at 5 weeks) to determine the impact of CR on processing speed as measured by the MCCB.~The second phase of the study (R33) will compare the 40 hours of speeded brain training to 40 hours of non-speeded brain training. This three year study will allow for a replication and assessment of specificity of the targeted intervention.
Study NCT05131035 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: SCORES (Specific COgnitive Remediation with Support)
Description: This study evaluates the effectiveness of a 10-week cognitive remediation program plus group coaching and therapy to improve processing speed and, in turn, social functioning and attenuated positive symptoms in CHR subjects. The SCORES (Specific COgnitive Remediation with Support) intervention is a novel CR program combined with group coaching, performance-based rewards, game-like tasks, and therapy elements to increase engagement and retention.~In the 2 year, R61 phase, all participants will complete 40 hours of CR (4 hrs per week) with a mid-point assessment (20 hours of CR at 5 weeks) to determine the impact of CR on processing speed as measured by the MCCB.~The second phase of the study (R33) will compare the 40 hours of speeded brain training to 40 hours of non-speeded brain training. This three year study will allow for a replication and assessment of specificity of the targeted intervention.
Study NCT05754372 — intervention group
Intervention type: DIAGNOSTIC_TEST
Intervention: user-friendly and widely applicable algorithm to tailor the treatment of acute neonatal hyperammonemia
Description: user-friendly and widely applicable algorithm to tailor the treatment of acute neonatal hyperammonemia, based on kinetic modelling
Study NCT05740644 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: CM-1600
Description: Healthy subjects undergoing a manual blood loss of up to 500mL followed by an infusion of 1 liter of normal saline will be connected to the CM-1600 device.
Study NCT04930172 — intervention group
Intervention type: DEVICE
Intervention: Steerable introducers
Description: endografts via total transfemoral approach for visceral vessels cannulation
Study NCT04653727 — intervention group
Intervention type: OTHER
Intervention: Cross-sectional survey
Description: No intervention.
Study NCT06025695 — intervention group
Intervention type: COMBINATION_PRODUCT
Group type: EXPERIMENTAL
Intervention: PCV-free liquid formulation of GSK's oral live attenuated HRV
Description: 2 doses of PCV-free liquid formulation of GSK's oral live attenuated HRV study intervention administered orally at Day 1 and Month 1, according to the immunization schedule for HRV study intervention licensed outside of China. PCV-free implies no detection of PCV-1 and PCV-2 according to the limit of detection of the tests used.
Study NCT04858035 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Perceptual training
Description: Perceptual training involves self-paced presentation of auditory stimuli via a computerized software program.~Stimuli are organized into three separate tasks:~Tasks 1 and 3 will train category goodness judgment: Participants will hear 75 naturally produced speech tokens containing /r/ from various speakers, with a balance of correct and incorrect productions. They will classify each /r/ as correct or incorrect and receive feedback on the accuracy of their classification. Tasks 1 and 3 differ in that task 1 will feature a subset of items designed to provide focused practice on a specific context (e.g., initial /r/ as in red; /r/ as syllable nucleus as in sir), with increasing difficulty over time, whereas task 3 will feature randomly selected items representing all contexts and difficulty levels.~Task 2: Participants will hear 75 items drawn from the synthetic rake-wake continuum used in the identification task administered at baseline.
Study NCT04858035 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Production training
Description: Instruction: Discuss tongue shapes for /r/. Pre-practice: relatively unstructured, highly interactive elicitation; provide models and placement cue and KP on every trial.~Structured syllable practice: Practice will occur in blocks of 10 consecutive trials on the same syllable (e.g., 10 /ra/), after which a new syllable will be addressed (e.g., 10 /re/--but note that in the fully blocked condition, the same syllable should occur in two consecutive blocks of 10).
Study NCT05139329 — intervention group
Intervention type: DIAGNOSTIC_TEST
Intervention: Imaging
Description: To better understand the prevalance of further imaging for evaluation of myocarditis, all patients with negative workup will be included and see what number of patients undergo further CMRI, FGD-PET, or speckle tracking echocardiography. Patients will then be categorized as those with myocarditis with positive diagnosis, negative diagnosis or unknown.
Study NCT04724694 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Brief CBT for Chronic Pain
Description: Brief CBT-CP is a manualized protocol that includes six, 30-minute sessions over the course of 6-12 weeks. Session one focuses on foundational pain education and the development of treatment goals. Session two emphasizes balanced engagement in physical activity and pleasurable events. Session three emphasizes skills training for easily implemented relaxation techniques. Sessions four and five focus on recognizing and modifying unhelpful thoughts that negatively impact pain. Session six focuses on relapse prevention and independent implementation of CBT-CP skills following treatment.
Study NCT04724694 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Treatment as usual
Description: Participants assigned to TAU will receive standard medical care from their primary care provider including pain medications, brief advice (e.g., use of relative rest, application of heat or ice, other self-care strategies), or referral to pain-related adjunctive interventions (e.g., physical therapy), as indicated.
Study NCT04724694 — intervention group
Intervention type: OTHER
Group type: OTHER
Intervention: Treatment as usual
Description: Participants assigned to TAU will receive standard medical care from their primary care provider including pain medications, brief advice (e.g., use of relative rest, application of heat or ice, other self-care strategies), or referral to pain-related adjunctive interventions (e.g., physical therapy), as indicated.
Study NCT06532500 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: CBT-MyOWL
Description: 12-sessions of CBT-MyOWL
Study NCT06532500 — intervention group
Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: CBT-as-usual
Description: 12-sessions of CBT using Mind Over Mood or Anxiety Phobia
Study NCT05225077 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Dapagliflozin 10 MG [Farxiga]
Description: Dapagliflozin 10 mg once a day for 1 month after CAG or PCI.
Study NCT03920462 — intervention group
Intervention type: DEVICE
Group type: OTHER
Intervention: Programme of intelligent electric bike for health
Description: It is a programme of 6 excursions with an intelligent electric bike for health and connected vests during 1 month (two excursions per week according the weather)
Study NCT06095934 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: neo-antigen vaccine
Description: anti-PD-1 monoclonal antibody combined with neoantigen peptide vaccine and chemotherapy
Study NCT06219967 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Activated Charcoal
Description: Activated charcoal alone
Study NCT06219967 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Activated Charcoal
Description: Activated charcoal mixed with cola
Study NCT06421519 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: BiPAP setting
Description: Infants in this arm of the study will each rotate through three different BiPAP settings. The following BiPAP settings will be used:~13cmH2O / 5cmH2O, 10cmH2O / 5cmH2O, 7cmH2O / 5cmH2O
Study NCT06407128 — intervention group
Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Collection of biological samples
Description: Collection of biological samples (blood sample + valve tissue sample + saliva, periodontal and feces sample)
Study NCT05984758 — intervention group
Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: AS-OCT imaging
Description: Image acquisition with the Optovue RTVue OCT and the Heidelberg Spectralis OCT2 machines
Study NCT05984758 — intervention group
Intervention type: DIAGNOSTIC_TEST
Group type: ACTIVE_COMPARATOR
Intervention: Slit lamp examination
Description: SLE of anterior chamber
Study NCT04927351 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Electronic Medical Record Based Discharge Medication Order Set
Description: New medication discharge order set including recommended opioid quantities, adjunct pain medication
Study NCT05097976 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Methylprednisolone
Description: 21 x 4mg tablets beginning on POD 1
Study NCT05097976 — intervention group
Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: 21 sugar tablets beginning on POD 1 with standard management
Study NCT04840849 — intervention group
Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: nirsevimab
Description: Drug: injection, a single fixed IM dose on day 1 only.
Study NCT04840849 — intervention group
Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Placebo: injection, 0.9% (w/v) saline, a single fixed IM dose on day 1 only.
Study NCT05968495 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Renuvion APR Handpiece
Description: The Renuvion® APR (Apyx Plasma/RF) handpiece is a sterile, single use electrosurgical (monopolar) device intended to be used in conjunction with a compatible generator for the delivery of radiofrequency energy and helium plasma for cutting, coagulation and ablation of soft tissue during open surgical procedures. Radiofrequency energy is delivered to the handpiece by the generator and used to energize the electrode. When helium gas is passed over the energized electrode, a helium plasma is generated for cutting, coagulation or ablation of soft tissue during open surgical procedures. The compatible generators operate at an adjustable power of up to 40 W (expressed as 0 - 100% where 100% is 40 W) and provide an adjustable helium gas flow of 1 - 5 L/Min. APR Handpiece has a non-extendable electrode to generate helium plasma.
Study NCT06145035 — intervention group
Intervention type: BIOLOGICAL
Group type: PLACEBO_COMPARATOR
Intervention: umbilical cord-derived mesenchymal stromal cells (UC-MSCs)
Description: The study product will consist of 100 million UC-MSCs suspended in a final volume of 60 ml given at a rate of 3.3 million cells/min. The product will be infused into vein via intravenous line placed in the arm.
Study NCT05616572 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: OncoWhiz
Description: OncoWhiz is an online educational tool designed to supplement current institutional caregiver education. OncoWhiz requires low graphical demands, has no-end user downloads, and is compatible with both desktop and mobile phones. Questions are derived from the institutional binder and are written at a fifth-grade reading level for user accessibility.
Study NCT05124067 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Dexamethasone
Description: patients will receive dexamethasone (0.15 mg/kg IV; maximum 5 mg)
Study NCT05124067 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Ondansetron
Description: patients will receive ondansetron (0.05 mg/kg IV; maximum 4 mg)
Study NCT05124067 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Dexmedetomidine
Description: Patients will receive dexmedetomidine (0.3 μg/kg)
Study NCT05124067 — intervention group
Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: normal Saline
Description: patients will receive normal saline.
Study NCT06145035 — intervention group
Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: umbilical cord-derived mesenchymal stromal cells (UC-MSCs)
Description: The study product will consist of 100 million UC-MSCs suspended in a final volume of 60 ml given at a rate of 3.3 million cells/min. The product will be infused into vein via intravenous line placed in the arm.
Study NCT05219149 — intervention group
Intervention type: BEHAVIORAL
Intervention: Qualitative Interviews
Description: Conduct qualitative interviews with patients and families who are considering treatment options for new or recurrent CNS tumors to identify specific barriers to full participation in treatment and clinical trial enrollment (e.g., transportation, childcare, ancillary expenses). Qualitative interviews will be structured to comprehensively address potential barriers but also open-ended to give patients and families freedom to discuss a wide range of challenges.
Study NCT05136222 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Intervention polysomnography
Description: Please refer to 'Arms: Intervention' section.
Study NCT05136222 — intervention group
Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Sham polysomnography
Description: Please refer to 'Arms: Control' section.
Study NCT05327660 — intervention group
Intervention type: COMBINATION_PRODUCT
Group type: EXPERIMENTAL
Intervention: Quitline Treatment as Usual (TAU)
Description: Quitline TAU is services provided by the state quitline and includes phone coaching, nicotine replacement, supplemental materials (e.g., text messaging, online content).
Study NCT05327660 — intervention group
Intervention type: COMBINATION_PRODUCT
Group type: ACTIVE_COMPARATOR
Intervention: Quitline Treatment as Usual (TAU)
Description: Quitline TAU is services provided by the state quitline and includes phone coaching, nicotine replacement, supplemental materials (e.g., text messaging, online content).
Study NCT05327660 — intervention group
Intervention type: COMBINATION_PRODUCT
Group type: EXPERIMENTAL
Intervention: Remote Carbon Monoxide (CO) Monitoring
Description: Remote CO monitoring includes a smartphone app and a remote carbon monoxide monitor. The app tracks and prompts daily use of the CO monitor.
Study NCT05327660 — intervention group
Intervention type: COMBINATION_PRODUCT
Group type: EXPERIMENTAL
Intervention: Incentivized Remote CO Monitoring
Description: Incentivized remote CO monitoring includes a smartphone app and a remote carbon monoxide monitor. The app tracks and prompts daily use of the CO monitor and delivers small monetary incentives for each use of the CO monitor.
Study NCT06549504 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: AG2202T
Description: AG2202T Single-dose
Study NCT06549504 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: AG2202R
Description: AG2202R Single-dose