AIM-Harvard/TrialPanorama-filtered huggingface dataset:
Study NCT06536595 — intervention group
Intervention type: OTHER
Intervention: Scales
Description: Participants were asked to complete the HAnDE-T, MHISS, SF-36 and HAQ when they first came. After 1 week, they were asked to complete HAnDE-T for re-test.
Study NCT06455566 — intervention group
Intervention type: DEVICE
Intervention: Leadless pacemaker implantation through right internal jugular vein
Description: Leadless pacemaker implantation through right internal jugular vein
Study NCT06585059 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: TQB2928 injection + Almonertinib Mesilate Tablets
Description: TQB2928 is a recombinant fully humanized Immunoglobulin G4 (IgG4) monoclonal antibody that can promote tumor cell phagocytosis by macrophages and exert anti-tumor effects.~Almonertinib Mesilate Tablets is a third generation of EGFR-TKI targeting drug.
Study NCT05778227 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Ethylene Diamine Tetra Acetic acid
Description: Final irrigation will be done with 5ml of EDTA for 1min which is the gold standard and compare it with experimental irrigants.
Study NCT05778227 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: smearOFF
Description: Final irrigation of root canal treatment procedure will be done with 5ml of smearOFF for 1min.
Study NCT05778227 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Etidronic acid /sodium hypochlorite
Description: During whole procedure of cleaning and shaping combination product of HEBP/NaOCl will be used
Study NCT06113718 — intervention group
Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Abdominal Exercise (digital rectal stimulation, abdominal massage)
Description: The recommended bowel exercise program consisted of three steps:~1. Patients will perform a 2-3 minute massage starting from the cecum approximately 20-30 minutes after breakfast, moving along the colon.~2. Patients will assume a suitable position and perform circular massage on the anal walls with their finger for approximately 30 seconds (digital rectal stimulation).~3. Patients will try to defecate while sitting on the toilet.
Study NCT06468488 — intervention group
Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: DIEP flap surgery without drain
Description: Patients will undergo a breast reconstruction with a DIEP flap without the placement of drains.
Study NCT06468488 — intervention group
Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: DIEP flap surgery with drains
Description: Patients will undergo a breast reconstruction with a DIEP flap with the placement of drains.
Study NCT05778227 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Maleic acid
Description: Final irrigation of root canal treatment procedure will be done with 5ml of maleic acid for 1min.
Study NCT04496258 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Positive Emotion Induction
Description: Participants are expected to have a positive emotional response to the more positive beach scene.
Study NCT05929040 — intervention group
Intervention type: BEHAVIORAL
Group type: OTHER
Intervention: mindful cognitive intervention
Description: Mindfulness based cognitive intervention based on the behavioural change techniques taxonomy
Study NCT05929040 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: mindful cognitive intervention
Description: Mindfulness based cognitive intervention based on the behavioural change techniques taxonomy
Study NCT04496258 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Neutral Emotion Induction
Description: Participants are expected to have a neutral emotional response to the neutral office scene.
Study NCT05389124 — intervention group
Intervention type: BEHAVIORAL
Intervention: Partial abstinence from oral hygiene
Description: One quadrant of the dentition will be protected from oral hygiene for 3 weeks.
Study NCT06242977 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Eutectic mixture of local anesthetics (EMLA; Astra Pharmaceutical Products Inc., Westborough, MA)
Description: The intervention is the utilization of EMLA cream, a topical anesthetic to determine if this reduces pain with local anesthesia infiltration, and for overall procedural pain
Study NCT06242977 — intervention group
Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Control cream
Description: This intervention will be for the control group, a simple lotion cream.
Study NCT05105035 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Ceftazidime or meropenem
Description: Patients will be prescribed ceftazidime or meropenem intravenously as per standard of care for at least 14 days while in the hospital
Study NCT05105035 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Ceftazidime or meropenem
Description: Patients will be prescribed ceftazidime or meropenem intravenously as per standard of care for at least 14 days while in the hospital
Study NCT05105035 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ARV-1801
Description: Patients will be prescribed ARV-1801 at 1500mg 12 hours apart on Day 1 and 600mg every 12 hours for Days 2-14.
Study NCT05105035 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Placebo
Description: Patients will be prescribed placebo every 12 hours for Days 1-14.
Study NCT05647733 — intervention group
Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Low splanchnic blood volume restrictive fluid management strategy
Description: Hemodynamic goal-directed restrictive fluid management strategy.
Study NCT05647733 — intervention group
Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Optimized cardiac output liberal fluid management strategy
Description: Permissive intraoperative hemodynamic goal-directed fluid management strategy that optimizes cardiac output throughout surgery
Study NCT05647733 — intervention group
Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Phlebotomy
Description: Retrieval of blood in a blood donation bag performed prior to dissection and transfused back after graft reperfusion
Study NCT05430386 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: HS-10241
Description: Dose escalation: HS-10241 and Almonertinib will be administered in combination. Participants will continue treatment until the end of the study in the absence of unacceptable toxicities and confirmed disease progression.~Dose expansion: HS-10241 and Almonertinib will be administered in the dose identified in Part 1 to further investigate the safety, tolerability, pharmacokinetics, and efficacy of this combination therapy.
Study NCT06567132 — intervention group
Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Non-surgical periodontal treatment
Description: Non-surgical periodontal treatment was performed in a single session using an ultrasonic device and a manual scaler. Polishing was done using polishing paste and rubber cup. Clinical periodontal indices, saliva and gingival crevicular samples were repeated after six weeks follow-up period.
Study NCT04989257 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Ticagrelor-based dual-antiplatelet therapy
Description: Aspirin with ticagrelor
Study NCT04989257 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Clopidogrel-based dual-antiplatelet therapy
Description: Aspirin with clopidogrel
Study NCT04819932 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: DWJ1451
Description: DWC202008 DWC202009
Study NCT05696015 — intervention group
Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Standard education
Description: Without telehealth education, this group has only postdischarge education.
Study NCT05696015 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Ampiled Education
Description: With telehealth education, in addition of discharge education.
Study NCT06060314 — intervention group
Intervention type: PROCEDURE
Group type: OTHER
Intervention: Conservative Approach
Description: Patients in Group A were treated conservatively i.e Splinting in neutral position of wrist for 6 wks min at night and during the day as preferred
Study NCT06060314 — intervention group
Intervention type: PROCEDURE
Group type: OTHER
Intervention: Surgical Approach
Description: Patients in Group B were managed through surgical intervention i.e open carpal tunnel release (OCTR)
Study NCT05775198 — intervention group
Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: PBMC immunomodulated with IFNt
Description: Autologous peripheral blood mononuclear cells (PBMC) isolated using a standard protocol will be cultured in the presence of interferon tau (IFNt) for 24 hours at 37 ˚C and administered in the uterine cavity of patients 1 day prior to embryo transfer.
Study NCT05124873 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Moisture Management Liner
Description: A prototype liner designed to reduce heat that builds up on the limb.
Study NCT04877197 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: BA-HT
Description: Behavioral Activation for depression delivered via home-based telehealth (BA-HT) will be implemented over 12, weekly 50-minute sessions via VA approved telehealth software.
Study NCT04877197 — intervention group
Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Standard Care
Description: Best practices standard care delivery for post-CVD hospitalization as regularly implemented at the RHJ VAMC. Standard care may include all or some of the following: post-operative follow up, referral to VA primary care clinic at 1 month post-procedure, primary care visit with VA mandated assessments of pain and depression with referral for these conditions, referral to facility-based or home-based cardiac rehabilitation program as appropriate. All participants in this condition will be referred to mental health care. In addition, these participants will receive a weekly telephone call from project staff during which time supportive questioning about patient progress and general mood and recovery.
Study NCT05405673 — intervention group
Intervention type: DIAGNOSTIC_TEST
Intervention: Fecal immunochemical test (FIT)
Description: A kind of stool test
Study NCT06293417 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Ezetimibe/fenofibrate (Ezefeno) and moderate-intensity statin
Description: Treatment group
Study NCT06293417 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Dose escalation of moderate-intensity statin
Description: Control group
Study NCT03697954 — intervention group
Intervention type: DEVICE
Intervention: full stage implantation of sacral neuromodulation
Description: full stage implantation of sacral neuromodulation for overactive bladder and urge incontinence
Study NCT05686408 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: TNX-601 ER
Description: Patients will take 1 pill orally once daily for 6 weeks.
Study NCT05686408 — intervention group
Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Patients will take 1 pill orally once daily for 6 weeks.
Study NCT06383364 — intervention group
Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Medication Coordinator
Description: The Medication Coordinator calls the patient app seven days after discharge in the transition of care from hospital to home
Study NCT06149637 — intervention group
Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Traditional neck dissection approach
Description: .1. A transverse cervical incision is made with horizontal extension towards the affected side. 2. It is dissected through the subplatysmal plane, the posterior edge of the sternocleidomastoid muscle is dissected along its entire length. 3. Identification and dissection of the spinal nerve at Erb's point. 4. Level V nodes are dissected up to the spinal nerve without identifying or dissecting it 5. The jugular chain nodes are identified and the left level IV nodes are dissected with special attention to ligate the lymphatics of this level 6. Identification and dissection of level III nodes 7. Identification and dissection of level IIA and IIB ganglia with identification and preservation of the accessory nerve.
Study NCT06149637 — intervention group
Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Anterior neck dissection approach
Description: 1. A transverse cervical incision is made with horizontal extension towards the affected side.~2. It is dissected through the subplatysmal plane, the anterior edge of the sternocleidomastoid muscle is dissected along its entire length.~3. Level V nodes are dissected up to the spinal nerve without identifying or dissecting it~4. The jugular chain nodes are identified and the left level IV nodes are dissected with special attention to ligate the lymphatics of this level~5. Identification and dissection of level III nodes~6. Identification and dissection of level IIA and IIB nodes with identification and preservation of the accessory nerve.
Study NCT06359405 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: drug safety simulation
Description: The intervention's purpose is to develop a simulation program to increase nursing students' crisis management skills regarding medication safety. This simulation program will provide students with the opportunity to develop skills in recognizing, evaluating, and effectively intervening in medication errors in real-world scenarios.~The simulation program will include interactive case scenarios, virtual patients, and simulation sessions led by an instructor providing feedback to students. Also, medicine Learning materials covering preventing, recognizing, and correcting errors will also be provided.
Study NCT06393361 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Chidamide; Decitabine; Anti-PD-1 Antibody
Description: Chidamide 10mg/day, day1-4; 20mg/day, day 8,11, 15, 18. Decitabine 10mg/day, day1-5. Physicians will decide which immune checkpoint inhibitors will be used during treatment.
Study NCT06393361 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Brentuximab Vedotin, anti-PD-1 antibody.
Description: Brentuximab Vedotin 1.8mg/kg d1, anti-PD-1 antibody d1. Physicians will decide which immune checkpoint inhibitors will be used during treatment.
Study NCT04848766 — intervention group
Intervention type: DRUG
Intervention: De-escalation Treatment Strategy of dual antiplatelet therapy
Description: Patients receive de-escalation treatment of dual antiplatelet therapy after percutaneous coronary intervention
Study NCT05872035 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Apple Software
Description: Amplification settings established by algorithm and further adjusted by participants per their preference
Study NCT05872035 — intervention group
Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: by Audiologist
Description: Amplification settings established by clinical reference and further adjusted by an audiologist per current best practice
Study NCT06592313 — intervention group
Intervention type: PROCEDURE
Intervention: Intubation
Description: Aiway management procedure involving the Insertion of an orotracheal cannula through the oropharynx.
Study NCT05540886 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: TEACH CLEAN
Description: The intervention is primary a training facility cleaning champions to educate and supervise other existing facility cleaners with environmental hygiene responsibilities - training of trainers (ToT).~The training content includes as much as possible the seven contextualized modules of TEACH CLEAN training package (CLEAN BOX): i) Introduction to Infection Prevention and Control, ii) Personal hygiene and dress code, iii) Hand hygiene, iv) Personal protective equipment, v) Housekeeping/control of environment, vi) Waste handling, and vii) Linen handling.~Facility training will occur in three selected wards: i) maternity ward, including labour and post-natal rooms, ii) medicine ward, iii) and medicine ward.~There is also supervision stage that refers to ongoing mentorship of cleaning champions by the local partner while they educate and supervise existing facility cleaners with environmental hygiene responsibilities.
Study NCT06662643 — intervention group
Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Delayed transanal pull-through anastomosis
Description: Laparoscopic surgery is recommended. A standard 5-port method is used to create pneumoperitoneum after placing the trocar. The sigmoid colon and upper rectal mesentery are dissected along Toldt's fascia. Autonomic nerves should be preserved, and high ligation of the inferior mesenteric vessels with lymph node dissection is recommended. TME: Using a posterior-to-anterior approach, the mesorectal plane is dissected down to the pelvic floor, cutting the Waldeyer's fascia to enter the intersphincteric space, where sharp dissection is carried out toward the levator ani muscle hiatus. The dissection endpoint is the dentate line, where the proximal colon is exteriorized by at least 2 cm and sutured to the anal canal with 6-8 stitches, without a protective ileostomy.Two to four weeks after the first surgery, after the colon has adhered well to the surrounding tissue, the exteriorized colon is excised (under epidural or spinal anesthesia, trimming the exteriorized colon to form the anus).
Study NCT06662643 — intervention group
Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Direct Anastomosis Plus Prophylactic Ileostomy
Description: ISR is categorized into partial ISR (PISR), subtotal ISR, and total ISR (TISR). Correspondingly, the anastomosis site after coloanal anastomosis is located below the levator ani hiatus (PISR, near the dentate line; subtotal-ISR and TISR, below the dentate line).The dissection steps are the same as in the first stage of the Staged Turnbull-Cutait Pull-through Anastomosis group (TME and intersphincteric space dissection).The bowel is transected at least 1 cm below the tumor, leaving a larger segment of healthy tissue on the non-tumor side while ensuring that no more than 1/3 of the dentate line is resected to avoid impairing fecal control.Anastomosis is performed using absorbable sutures under direct visualization. A protective ileostomy is created 25-30 cm from the ileocecal valve.3 to 6 months after surgery, the ileostomy is reversed. Prior to closure, digital rectal examination, defecography, MRI, colonoscopy, and other evaluation must perform.
Study NCT06662682 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Whole-Body Vibration
Description: The intervention (IC) will be specified as a five-minute Whole-Body Vibration session. The WBV take place on a side alternating vibration plate (Wellengang, Germany). The patients stand barefoot on the vibration plate on a prescribed position. In this position the amplitude will be 6-7mm. The WBV protocol contains mobilizing sequences with lower frequencies and activating sequences with higher frequencies
Study NCT06662682 — intervention group
Intervention type: OTHER
Group type: OTHER
Intervention: Control Condition
Description: Non-intervention control condition
Study NCT06663826 — intervention group
Intervention type: DIAGNOSTIC_TEST
Intervention: oculomotor and pupillary function assessment
Description: This is an exploratory open-label single-centre research project intended to collect data of PD patients in order to develop machine learning models for helping in the diagnosis and monitoring of PD. Each patient will have an initial visit and then a second visit after two weeks. The estimated duration of the study visit 1 is 3 hours, not taking into account the time for patient information and informed consent. The estimated duration of the study visit 2 is 2 hours. During these two visits, patients will undergo an MDS-UPDRS assessment, a neos examination, a standard manual ocular motor and pupil function examination, and gait assessment simultaneously with GaitQ senti and an IMU sensor placed on their back. In the two weeks separating the two visits, patient's gait will be monitored daily at home with GaitQ senti, where they will perform a daily TUG test comprising of 15 m walk, 5 sit to stand, and 5-minute walk. Healthy individuals data will be included from a previous study.
Study NCT06663254 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Hydroxyethyl starch 130/0.4
Description: Individualized goal-directed administration of 6% Hydroxyethyl starch (HES) 130/0.4: After the induction of anesthesia, 200 ml trial fluid will be infused over 20 min. If stroke volume (SV) increases \&gt;10%, another 200 ml fluid will be given. After that, the use of trial fluid will be determined by the patients' Stroke Volume Variation (SVV). If the SVV exceeds 12%, 200 ml trial fluid will be given over 20 min; this will be repeated until SVV \&lt;12%. If the use of HES exceeds 30 ml/kg, sodium acetate Ringer will be replaced. In addition, patients will have a background infusion of sodium acetate Ringer's solution at 4 ml/kg/h to satisfy the maintenance fluid requirements during surgery.
Study NCT06663254 — intervention group
Intervention type: DRUG
Group type: OTHER
Intervention: Sodium acetate Ringer
Description: Individualized goal-directed administration of crystalloid alone: After the induction of anesthesia, 200 ml trial fluid will be infused over 20 min.~If stroke volume (SV) increases \&gt;10%, another 200 ml fluid will be given. After that, the use of trial fluid will be determined by the patients' Stroke Volume Variation (SVV). If the SVV exceeds 12%, 200 ml trial fluid will be given over 20 min; this will be repeated until SVV \&lt;12%. In addition, patients will have a background infusion of sodium acetate, the maintenance fluid requirement during surgery.
Study NCT06662669 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: YL-13027
Description: YL-13027 is a small molecule inhibitor of the TGF-βRI target.
Study NCT06662669 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: HY-0102
Description: HY-0102 is a recombinant anti-NKG2A humanized monoclonal antibody.
Study NCT06662669 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Gemcitabine
Description: Gemcitabine is a pyrimidine antineoplastic chemotherapeutic agent.
Study NCT06662669 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Gemcitabine
Description: Gemcitabine is a pyrimidine antineoplastic chemotherapeutic agent.
Study NCT06662669 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Nab-paclitaxel
Description: Paclitaxel for Injection (albumin bound) is a chemotherapeutic agent that acts as an antitumor agent by inhibiting tumor cell mitosis
Study NCT06662669 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Nab-paclitaxel
Description: Paclitaxel for Injection (albumin bound) is a chemotherapeutic agent that acts as an antitumor agent by inhibiting tumor cell mitosis
Study NCT05591417 — intervention group
Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Bilevel Erector spinae plane block
Description: Patients will receive bilevel erector spinae plane block with bupivacaine