AIM-Harvard/TrialPanorama-filtered huggingface dataset:
Study NCT06095375 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Temozolomide
Description: Following a 3+3 design, in cohort A three patients will be administered temozolomide 150-200 mg/m2 for 5 consecutive days every 28 days until 6-12 cycles and regorafenib daily for 21 days, with a 1-week washout period at dose of 80 mg (level 1), 120 mg (level 2), or 160 mg (level 3) (regorafenib 40 mg- level -1). As a general rule, one cycle will last 28 days (day 1-28); however, in the event of treatment prolongation, the cycle period will be extended.~In cohort B,During concomitant therapy phase: temozolomide 75 mg/m2/die for 42 (max 49 days) consecutive days (concomitant with radiation therapy).
Study NCT05740436 — intervention group
Intervention type: OTHER
Intervention: Geriatric rehabilitation program based on CGA
Description: Geriatric rehabilitation program based on CGA will be performed under physicians tight control for 21 days and will include physical activity, psychological training, diet correction, adaptation measures, polypragmasia correction.
Study NCT05190523 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ASC42 5 mg
Description: 5 mg of ASC42 tablets orally once daily for 12 weeks.
Study NCT05190523 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ASC42 10 mg
Description: 2 x 5 mg of ASC42 tablets orally once daily for 12 weeks.
Study NCT05190523 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ASC42 15 mg
Description: 15 mg of ASC42 tablets orally once daily for 12 weeks.
Study NCT05190523 — intervention group
Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Placebo tablets orally once daily for 12 weeks.
Study NCT05041114 — intervention group
Intervention type: DEVICE
Group type: OTHER
Intervention: Motor Neuroprosthesis
Description: Type of implantable brain computer interface
Study NCT04883424 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Diabetes Education Program Based on Health Belief Model
Description: After the application, increase in family support and decrease in blood sugar levels are expected in diabetic patients. Family members' diabetic attitudes are expected to increase.
Study NCT06100744 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Adalimumab
Description: SC Injection
Study NCT06100744 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Risankizumab
Description: Subcutaneous (SC) Injection
Study NCT05077969 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Famotidine
Description: 80 mg tablet, QID for 14 days
Study NCT05077969 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Celecoxib
Description: 400 mg (initial dose), then 200 mg capsule, BID for 5 days
Study NCT05077969 — intervention group
Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: tablet, QID for 14 days; capsule, BID for 5 days
Study NCT04390282 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Application-based support system
Description: All participants (experimental and control group) will be invited to a separate appointment at the vascular open clinic at baseline and after three months and measured regarding weight, blood pressure, Ankle Brachial Pressure Index, six minutes walking test and pain. To calculate the estimate 10-year risk of manifesting clinical cardiovascular disease, the Framingham Risk Score will be used. Further, a questionnaire will be answered at baseline and after three months containing the instruments, VascuQoL-6, Health Education Impact Questionnaire and Medication Adherence Report Scale-5.
Study NCT06327919 — intervention group
Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Probiotic supplement
Description: multi-strain probiotics were used in this study. Each probiotic capsule contains Lactobacillus acidophilus, Bifidobacterium bifidum, Bifidobacterium lactis, Bifidobacterium longum, Lactobacillus reuteri, Lactobacillus rhamnosus, magnesium stearate and maltodextrin. 1.8 × 109 CFU / capsule. 2 capsules per day, for 12 weeks
Study NCT06327919 — intervention group
Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Placebo supplement
Description: The placebo capsule contains 300 mg of starch. 2 capsules per day, for 12 weeks
Study NCT05530525 — intervention group
Intervention type: DIAGNOSTIC_TEST
Intervention: The Computerized Adaptive Testing system of the Functional Assessment of Stroke
Description: The Computerized Adaptive Testing system of the Functional Assessment of Stroke comprises 58 items. The items were selected from four well-known physical function measures for patients with stroke: 26 items from the Fugl-Meyer Assessment-Upper limb, 11 items from the Fugl-Meyer Assessment-Lower limb, 12 items from the Postural Assessment Scale for Stroke Patients, and 9 items from the Barthel Index. These items evaluate motor control, postural control, and activity of daily living functions in patients with stroke. Results are automatically reported as Rasch scores (i.e., the minimum and maximum values are negative and positive infinity, respectively). A higher score indicates greater physical functions.
Study NCT05530525 — intervention group
Intervention type: DIAGNOSTIC_TEST
Intervention: The Barthel Index
Description: The Barthel Index has 10 items, and the total score ranges from 0 to 100. Higher score indicates less disability on activity of daily living functions.
Study NCT05530525 — intervention group
Intervention type: DIAGNOSTIC_TEST
Intervention: The National Institutes of Health Stroke Scale
Description: The National Institutes of Health Stroke Scale comprises 11 items and was used to monitor the severity in the patients with stroke. The total score ranges from 0 to 42, with a higher score indicating greater severity. A National Institutes of Health Stroke Scale score of 1-5 indicates mild severity; 6-14, mild to moderate severity; 15-24, severe severity; and equal to or greater than 25, very severe severity.
Study NCT06600711 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Nitazoxanide
Description: 5 mL suspension (100 mg), 2x/day for 3 days
Study NCT06600711 — intervention group
Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: identical in consistency, appearance, and taste to nitazoxanide suspension. 5 mL suspension given 2x/day for 3 days
Study NCT06600074 — intervention group
Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Back care advice
Description: All patients in both groups will be advised to use proper lifting techniques, avoid prolonged sitting or standing, maintain a healthy weight, quit smoking, practice good posture, take breaks, spread housekeeping duties over the whole week, and sleep in supportive positions.
Study NCT06600074 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Back care advice
Description: All patients in both groups will be advised to use proper lifting techniques, avoid prolonged sitting or standing, maintain a healthy weight, quit smoking, practice good posture, take breaks, spread housekeeping duties over the whole week, and sleep in supportive positions.
Study NCT06600074 — intervention group
Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Postural correction exercises
Description: All patients in both groups will be instructed to perform postural correction exercise. They will be performed from different positions (crock lying, supine lying, supine, sitting and standing position). They will lie in crock lying position for example and the physical therapist will instruct them to do chin in , open out ribs through costal breathing, contract abdominal muscles, contract glutei, hold for 6 seconds and relax and repeat 10 times.
Study NCT06600074 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Postural correction exercises
Description: All patients in both groups will be instructed to perform postural correction exercise. They will be performed from different positions (crock lying, supine lying, supine, sitting and standing position). They will lie in crock lying position for example and the physical therapist will instruct them to do chin in , open out ribs through costal breathing, contract abdominal muscles, contract glutei, hold for 6 seconds and relax and repeat 10 times.
Study NCT06600074 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Retro-walking
Description: Patients in the experimental group only will practice walking backward on a treadmill, starting with a 5-minute warm-up at a self-selected speed, then gradually increasing speed from 1.2 to 1.6 m/s based on comfort and progress.
Study NCT06110793 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Lenvatinib
Description: 20mg orally PO daily
Study NCT06110793 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Pembrolizuma
Description: 400mg IV Q6W
Study NCT06110793 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Fulvestrant
Description: 500mg IM Q4W
Study NCT06692569 — intervention group
Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Conventional Physical Therapy
Description: The conventional Physical Therapy, the treatment will be based on the client's capabilities. It included functional reeducation, muscle strengthening and stretching, muscle tone regulation methods, and training for activities of daily living
Study NCT06692569 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Modified Constraint Induced Movement Therapy
Description: Modified Constraint Induced Movement Therapy (mCIMT) which involves trunk constraint along with conventional Physical Therapy treatment. Under the attentive guidance of a physiotherapist, the patient engages in specific hand activities aligned with personalized goals. These activities encompass tasks such as picking up marbles, flipping cards, stacking blocks, combing hair, writing, and other actions relevant to daily life. The difficulty level is dynamically adjusted according to the patient's abilities and progress during the training sessions.Tasks may vary from one patient to another, and each session introduces fresh, goal-oriented challenges to further enhance rehabilitation outcomes, along with the conventional physical therapy treatment. The patients were wearing a trunk west which had a Velcro strap on the non-effected side part of the west, and it was attached to the Velcro straps on the non-affected part on the back support of the treatment chair.
Study NCT06692829 — intervention group
Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: robotic rehabilitation
Description: In addition to conventional therapy, the robotic therapy group was planned to receive robotic rehabilitation with a hand-finger robot \[Amadeo (Tyromotion, Graz, Austria)\] for 45 minutes, accompanied by a physiotherapist trained in robotic rehabilitation and with at least 5 years of experience. A total of 20 treatment sessions will be applied 2 days a week.
Study NCT06489015 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Recombinant Human Serum Albumin
Description: Each group receives the investigational drug (recombinant human serum albumin), with the distinction being the variation in dosing.
Study NCT05840783 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Open ended needle irrigation
Description: irrigation during root canal shaping and cleaning using an open-ended needle
Study NCT05840783 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: side vented needle irrigation
Description: irrigation during root canal shaping and cleaning using a 30-guage side-vented needle
Study NCT05840783 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Sonic activation
Description: Agitation of root canal irrigation solution with a sonic activation device (Endoactivator).
Study NCT04746339 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Apixaban 2.5 MG
Description: Apixaban 2.5mg twice daily for 30 days
Study NCT04746339 — intervention group
Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: placebo twice daily for 30 days
Study NCT06692829 — intervention group
Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: conventional rehabilitation
Description: It was planned for the conventional therapy group to receive an exercise program consisting of 45 minutes of active, passive range of motion exercises and strengthening exercises, accompanied by a physiotherapist with at least 5 years of experience in stroke rehabilitation. A total of 20 treatment sessions will be applied 2 days a week.
Study NCT05289427 — intervention group
Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: ultrasound guided triple injection peri-sartorius block
Description: Patients will receive ultrasound guided triple injection peri-sartorius block preoperatively before surgical incision
Study NCT05289427 — intervention group
Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Femoral Nerve Block
Description: Patients will receive femoral nerve block (FNB) before surgical incision
Study NCT06089603 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Continuous positive airway pressure
Description: Nocturnal continuous positive airway pressure by a nasal mask. CPAP pressure will be automatically titrated using a AutoSet device (ResMed)
Study NCT06089603 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Conventional pharmacological treatment
Description: Usual treatment of the patient
Study NCT06089603 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Conventional pharmacological treatment
Description: Usual treatment of the patient
Study NCT06089603 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Sleep ,diet and life style recomendations
Description: Daily recomendatios
Study NCT06692829 — intervention group
Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: conventional rehabilitation
Description: It was planned for the conventional therapy group to receive an exercise program consisting of 45 minutes of active, passive range of motion exercises and strengthening exercises, accompanied by a physiotherapist with at least 5 years of experience in stroke rehabilitation. A total of 20 treatment sessions will be applied 2 days a week.
Study NCT06089603 — intervention group
Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Sleep ,diet and life style recomendations
Description: Daily recomendatios
Study NCT06730061 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Elafibranor
Description: Tablet of 80 mg
Study NCT06746519 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: BN104 combined Intensive Chemotherapy or Venetoclax/Azacitidine
Description: The starting dose cohort(200mg BID N104) combined Intensive Chemotherapyor Venetoclax/Azacitidine. Each treatment cycle is anticipated to be 28 days in length, although cycle delays may be made due to delayed count recovery.
Study NCT06746961 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: QL1706 (bispecific antibody targeting PD-1 and CLTA-4)
Description: 5mg/kg , iv, q3w
Study NCT06746961 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Lenvatinib
Description: 8 mg or 12 mg QD via oral capsule
Study NCT06746207 — intervention group
Intervention type: OTHER
Intervention: Informed Consent Process Evaluation
Description: This study does not involve a clinical intervention. Instead, it focuses on evaluating the existing process of informed consent in a surgical setting. Patients and caregivers will be surveyed to assess their understanding, satisfaction, and perceptions of the informed consent process. The study examines factors such as clarity of information provided, patient and caregiver involvement, and overall satisfaction with the process, without altering the current practices. The goal is to identify areas for improvement in communication and documentation, ensuring that patient rights and autonomy are respected.
Study NCT06746974 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Shockwave
Description: In the Shockwave group, will be applied focused shockwaves therapy of 1500 impulses at 0.01 mJ/mm2 over the painful area or the pathologic flexor tendon to each participant under the supervision of a physiatrist. The ESWT will be conducted once weekly for 4 weeks with a sham splint (DIP joint blocking splints) for at least 8 hours per day for 6 weeks.
Study NCT06746974 — intervention group
Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Splint
Description: In the splinting group, will be provided a PIP blocking splint at least 8 hours per day for 6 weeks with the sham shockwave (the patients close their eyes, extend their hand through a partition, apply shockwave device head with gel on the patient's finger, and play a mobile phone sound that mimics the sound of a real shockwave machine) once a week for 4 weeks.
Study NCT05509270 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Letter
Description: Mailed letter about flu vaccination
Study NCT05509270 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Patient portal
Description: Patient portal message about flu vaccination
Study NCT05509270 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: SMS
Description: SMS about flu vaccination
Study NCT06747247 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: MT1013
Description: MT1013 is a dual-agonist polypeptide, not only to control iPTH levels in SHPT patients on maintainence dialysis, but also promote bone formation.
Study NCT06747247 — intervention group
Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Appear similar to MT1013, but has no treatment effect.
Study NCT05009459 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: eVIS
Description: To facilitate individualized physical activity levels within the Swedish IPRP setting, an eVISualisation (eVIS) of physical activity and pain intervention has been systematically developed. eVIS is designed to target facilitating mechanisms for behavior change, such as outcome expectations, self-monitoring, self-evaluation, and self-efficacy, which are theoretically framed by the Social Cognitive Theory by Bandura. In eVIS, objectively measured physical activity tracking using a wrist-worn activity tracker (Fitbit Versa 2) is combined with a daily activity goal (steps/day) and daily patient reports of known important clinical outcome assessments: pain intensity and its affect on daily activities30-34 and pharmaceutical consumption. Data is collected and visualized in a purpose-developed web application, Pin And TRaining ON-line (PATRON), which can be used by the patient and the IPRP-team to follow and adjust individual physical activity levels.
Study NCT06480305 — intervention group
Intervention type: DIETARY_SUPPLEMENT
Group type: ACTIVE_COMPARATOR
Intervention: Post dinner snack
Description: one walnut, 2 cashews, 2 almonds, and 2 pistachios.
Study NCT06480305 — intervention group
Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Post dinner snack
Description: one walnut, 2 cashews, 2 almonds, and 2 pistachios.
Study NCT06480305 — intervention group
Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Pre-Breakfast-1
Description: Prepackaged dose of 25 peanuts.
Study NCT06480305 — intervention group
Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Pre-Breakfast-2
Description: Prepackaged dose of 25 raisins
Study NCT06425367 — intervention group
Intervention type: DIAGNOSTIC_TEST
Group type: ACTIVE_COMPARATOR
Intervention: Antibiotic susceptibility testing
Description: antibiotic susceptibility testing is performed on MHR-SIR or MH medium depending on randomization
Study NCT06425367 — intervention group
Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Antibiotic susceptibility testing
Description: antibiotic susceptibility testing is performed on MHR-SIR or MH medium depending on randomization
Study NCT05567887 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: maplirpacept (PF-07901801)
Description: maplirpacept (PF-07901801)
Study NCT06558305 — intervention group
Intervention type: OTHER
Intervention: blood sample
Description: Total RNA will be extracted from the whole blood using a commercial extraction kit (RNA Extraction Kit, applied biotechnology Co.Ltd, Egypt) according to the manufacturer's instructions. RNA will be stored at -80°C.The extracted RNA will be used for cDNA synthesis using commercial kits (cDNA Synthesis Kit, applied biotechnology Co.Ltd, Egypt), according to the manufacturer's instruction.
Study NCT05265416 — intervention group
Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Piezosurgery
Description: Three vertical incisions will be made (3-mm depth and 8-10 mm length) after anesthesia. The cuts will be performed mesial and distal the upper canine as well as at an equal distance from the upper canine and 2nd premolar.
Study NCT05265416 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Low-level laser therapy
Description: GaALAs diode laser (wavelength: 810 nm and exposure time of 10 seconds\\point) will be applied around the upper canine in 10 sites from buccal and palatal.
Study NCT05265416 — intervention group
Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Traditional treatment
Description: The canine retraction in this group will be performed in conventional method. Closed nickel-titanium coil springs applying 150 g of force per side will be used for retraction of the upper canine.
Study NCT06275347 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Low-fat normoprotein Controlled Ketogenic Diet.
Description: Frank ketosis will consist of between 650 and 730 kcal/day in 5 meal times, based on commercial and vegetable preparations with low glycemic index, an average of 1.2 g of protein/kg of ideal weight/day, 20 g/day of lipids based on essential fatty acids and less than 60 g/day of absorbable carbohydrates. Patients will receive vitamin and sodium chloride, magnesium oxide, calcium carbonate. Mixed Ketosis one or two intakes of commercial preparations will be progressively replaced by proteins, which will increase by 100 to 150 Kcal/day, supplementation of vitamins and minerals will continue. Transition Stage simple carbohydrates and some complex carbohydrates are added to the previous program, in an approximate proportion of 30 to 35% protein, 25% fat and 40 to 45 % carbohydrates. Integral and maintenance phase: may vary between 1300 and 2250 kcal/day, with a macronutrient distribution of 50% carbohydrates, 25% proteins and 25% fats.