AIM-Harvard/TrialPanorama-filtered huggingface dataset:
Study NCT05032118 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Ketamine Hydrochloride
Description: Titratable ketamine infusion + low fixed-dose propofol.
Study NCT05032118 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Propofol
Description: Standard of care titratable propofol infusion.
Study NCT06323811 — intervention group
Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: CMR
Description: Advanced CMR imaging including a novel quantitative free-breathing 3D perfusion sequence, 3D LGE imaging and a cine Dixon sequence
Study NCT06323811 — intervention group
Intervention type: DIAGNOSTIC_TEST
Group type: ACTIVE_COMPARATOR
Intervention: CMR
Description: Advanced CMR imaging including a novel quantitative free-breathing 3D perfusion sequence, 3D LGE imaging and a cine Dixon sequence
Study NCT05425030 — intervention group
Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Low-Sodium Salt Substitute
Description: Tata SuperLite low-sodium salt substitute has 30% of the weight of the product replaced with potassium chloride (KCl) which is itself a non-prescription dietary supplement. Each household randomized to the intervention arm will receive one bag (1.5kg) per month to utilize instead of their usual table/cooking salt.
Study NCT05425030 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Information/Education
Description: Community health workers will provide basic information on high blood pressure, the health consequences of excessive salt consumption, and feedback to the participant on the likely quantity of salt s/he consumes (estimated using a questionnaire)
Study NCT05425030 — intervention group
Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Information/Education
Description: Community health workers will provide basic information on high blood pressure, the health consequences of excessive salt consumption, and feedback to the participant on the likely quantity of salt s/he consumes (estimated using a questionnaire)
Study NCT05675527 — intervention group
Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Low-dose PRP
Description: Injection
Study NCT05675527 — intervention group
Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: High-dose PRP
Description: Injection
Study NCT05675527 — intervention group
Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Saline
Description: Injection
Study NCT05743101 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Levofloxacin
Description: Levofloxacin is a quinolone antibiotics and newly identified neuro-protective agent.Endovascular thrombectomy is one of the treatments for acute ischemic stroke.
Study NCT05743101 — intervention group
Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Levofloxacin simulant
Description: Levofloxacin simulant is placebo.Endovascular thrombectomy is one of the treatments for acute ischemic stroke.
Study NCT04855292 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: TG103 injection
Description: TG103 injection, SC, once weekly
Study NCT04855292 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo
Description: Placebo control, SC, once weekly
Study NCT05605496 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: NP137
Description: IV infusion, 14mg/kg, Q3W
Study NCT05605496 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: anti-PD-1/PD-L1
Description: IV infusion, Q3W or Q6W anti-PD1/PDL1 are standard treatments and are prepared and administred as per respective SmPC and institutional practice.
Study NCT06342622 — intervention group
Intervention type: DIAGNOSTIC_TEST
Intervention: Using routine clinical data and machine learning models.
Description: This study used clinical data and machine learning model to screen young-onset colorectal cancer.
Study NCT06354361 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Trauma-Informed Goal Management Training (TI-GMT)
Description: Trauma Informed-Goal Management Training (TI-GMT) is a modified version of Goal Management Training (GMT), a cognitive remediation program that emphasises mindfulness and practice in planning and completing goal-oriented behaviours. TI-GMT enhances the standard GMT protocol with the addition of several trauma-informed adaptations and content that is sensitive and specific to public safety personnel with PTSD.~Participants are trained to interrupt ongoing disruptive behaviours through the resumption of executive control to help define goal hierarchies and monitor goal achievement. Mindfulness meditation helps develop attentional control and the skill of bringing one's mind to the present. Real-life examples are incorporated to illustrate goal attainment failures and successes, and participants practice solving complex, real-life tasks in sessions.~Sessions include instructional material, interactive tasks, discussion of real-life deficits, and homework/practice activities.
Study NCT06354361 — intervention group
Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Goal Management Training (GMT)
Description: Goal Management Training (GMT) is a cognitive remediation program that emphasises mindfulness and practice in planning and completing goal-oriented behaviours.~Participants are trained to interrupt ongoing disruptive behaviours through the resumption of executive control to help define goal hierarchies and monitor goal achievement. Mindfulness meditation helps develop attentional control and the skill of bringing one's mind to the present. Real-life examples are incorporated to illustrate goal attainment failures and successes, and participants practice solving complex, real-life tasks in sessions.~Sessions include instructional material, interactive tasks, discussion of real-life deficits, and homework/practice activities.
Study NCT05317585 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Continuous Glucose Monitor
Description: Continuous Glucose Monitor
Study NCT05317585 — intervention group
Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Routine Capillary Blood Glucose Monitoring (Fingerstick Glucose)
Description: Routine Capillary Blood Glucose Monitoring (Fingerstick Glucose)
Study NCT05280457 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: nivolumab-GX-188E-GX-I7
Description: * Nivolumab 3 mg/kg IV administered every 2 weeks~* GX-188E 2 mg IM at Weeks 1, 2, 4, 7, 10, 13, and 19~* GX-I7 1200 μg/kg or the recommended dose of the introductory safety cohort is administered at weeks 2, 10, and 18
Study NCT04737824 — intervention group
Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: An adaptation of the balloon-blowing exercise
Description: The participants were positioned in supine, on a semi-rigid surface, with the upper limbs placed above the level of the head, at rest. Their feet were also placed at a resting position on a wall and with their hips and knees at 90o of flexion. The cervical was placed in a neutral position and the pelvis was maintained in a posterior pelvic tilt, both structures corrected by the researcher. The participants were asked to contract the adductors, maintaining a bilateral and symmetric pressure between 10 and 15 mmHg on two sphygmomanometers placed between the knees. Also, an isometric contraction of the hamstrings and gluteus was requested. A Threshold®, with a minimum resistance of 5 cmH2O, and they were instructed to close their lips around the mouthpiece, to avoid air leaks. To start the exercise, it was transmitted to the participants to make a maximum inspiration through the nose, for two seconds. Subsequently, a maximum exhalation throughout the threshold was made for three seconds.
Study NCT06379256 — intervention group
Intervention type: RADIATION
Intervention: Photon or proton radiotherapy
Description: * 39.6-72.6 Gy (or Cobalt Gray Equivalent, CGE) in 22 fractions for tumors ≤1 cm from hepatic hilum, bowel, and heart.~* 30-66 Gy (or CGE) in 10 fractions for tumors >1 cm from hepatic hilum, bowel, and heart.~* 27.5-60 Gy (or CGE) in 5 fractions using stereotactic body radiation therapy (SBRT) techniques
Study NCT05472337 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Colchicine
Description: Oral colchicine (1 mg loading dose followed by 0.5 mg 1 hour later, administered 6 to 24 hours before angioplasty, followed by 0.5 mg (1 comp.) per day for 6 weeks.
Study NCT06251037 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Youth Aware of Mental Health in Galicia
Description: The program follows a manualized protocol, comprising five interactive one-hour class sessions with adaptations to the Galician school population.~The Inaugural Session consists of an interactive slide presentation, an introduction of materials, the delivery of the manual, and the poster's display. The Second Session involves group discussions on real-life dilemmas. The Third and Fourth Sessions focus on crisis situations, depression, suicidal ideation, and help-seeking behaviors through role-playing games. The Closing Session includes a collective summary of topics and addresses dynamic aspects emerging during the group experience.
Study NCT05867485 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: COVID-19 Discharge Education
Description: A discharge education brochure has been developed based on information from the literature to complement the verbal information provided to patients. The content of the education brochure includes the following:~1. Information about the spread of the virus and precautions to be taken.~2. Guidelines for cleanliness and disinfection of the environment.~3. Precautions regarding personal and wearable items.~4. Information about food and beverages.~5. Guidelines for personal hygiene practices.~6. Information about quarantine and isolation.~7. Guidelines for maintaining health and care (e.g., respiratory hygiene, cough etiquette, movement, range of motion exercises) (CDC, 2019; Ministry of Health of Turkey, 2020; CDC 2019 A-B-C-D).
Study NCT05145946 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Video Game Training Group 1
Description: Closed-loop audiomotor game. Home-based training sessions for 3.5 hours per week over an 8-week.
Study NCT05145946 — intervention group
Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Video Game Training Group 1
Description: Closed-loop audiomotor game. Home-based training sessions for 3.5 hours per week over an 8-week.
Study NCT05145946 — intervention group
Intervention type: BEHAVIORAL
Group type: SHAM_COMPARATOR
Intervention: Video Game Training Group 2
Description: Auditory memory game. Home-based training sessions for 3.5 hours per week over an 8-week.
Study NCT04737824 — intervention group
Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: An adaptation of the balloon-blowing exercise for seven weeks, three times a week, at home
Description: The participants were positioned in supine, on a semi-rigid surface, with the upper limbs placed above the level of the head, at rest. Their feet were also placed at a resting position on a wall and with their hips and knees at 90o of flexion. The cervical was placed in a neutral position and the pelvis was maintained in a posterior pelvic tilt, both structures corrected by the researcher. The participants were asked to contract the adductors, maintaining a bilateral and symmetric pressure between 10 and 15 mmHg on two sphygmomanometers placed between the knees. Also, an isometric contraction of the hamstrings and gluteus was requested. A Threshold®, with a minimum resistance of 5 cmH2O, and they were instructed to close their lips around the mouthpiece, to avoid air leaks. To start the exercise, it was transmitted to the participants to make a maximum inspiration through the nose, for two seconds. Subsequently, a maximum exhalation throughout the threshold was made for three seconds.
Study NCT05919992 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Metyrapone 250 mg Oral Tablets
Description: During one phase of the study: Metyrapone (pills of 250mg) on empty stomach: Day 1 0-1-1, day 2 1-2-2, day 3 2-3-3 day 4 3-4-4 day 5 4-4-4 day 6 4-4-4 day 7 4-0-0
Study NCT05919992 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Hydrocortisone 19.9mg s.c., pulsatile with a flow rate of 10μl/s
Description: Hydrocortisone will be delivered subcutaneously via a pump in a pulsed fashion with a flow rate of 10μl/s from day 1 to day 7 in a total daily dose of 19.9mg
Study NCT05919992 — intervention group
Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo 250 mg Tablets
Description: During another phase of the study: identical looking placebo pills starting Day 1 0-1-1, day 2 1-2-2, day 3 2-3-3 day 4 3-4-4 day 5 4-4-4 day 6 4-4-4 day 7 4-0-0
Study NCT05919992 — intervention group
Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo (0,9% NaCl solution)
Description: Placebo (0,9% NaCl solution) 19.9 mg/d subcutaneously via a pump in a pulsed fashion with a flow rate of 10μl/s from day 1 to day 7
Study NCT06053060 — intervention group
Intervention type: OTHER
Group type: OTHER
Intervention: Randomisation Standard Dynacup or Dynacup One C
Description: Randomisation
Study NCT05083624 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: rehabilation therapy
Description: After comprehensive assessment by doctors, nurses and rehabilitation therapists, patients gradually begin rehabilitation treatment.IMS 0: no mobilisation or passively exercised by staff. IMS 1: sitting in bed and actively exercising .IMS 2: passively moved to chair without standing.IMS 3: sitting over edge of bed.IMS 4: standing in front of bed.IMS 5: transferring bed to chair.IMS 6: marching on spot.IMS 7: walking with assistance of more than one person.IMS 8: walking with assistance of one person.IMS 9: walking independently with a gait aid.IMS 10: walking independently without a gait aid.
Study NCT04075799 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: high-intensity interval training
Description: The HIIT protocol consists of 8 weeks using stair climbing three times per week. The warm-up will consist of 2 minutes of ascending and descending the stairs at a comfortable pace. The high-intensity intermittent exercise will comprise 6-12 x 30-seconds bouts of ascending at an all-effort. A 30- seconds walking recovery will occur between the exercise bouts. Post-exercise the subject will walk during a 2-minute cool down. Every session will last between 10 to 15 minutes. The number of bouts (6-12) will be increased progressively over the weeks. The first (week 1) and final week (week 8) of the exercise program will be monitored by a trained exercise physiologist. During supervised visits, heart rate and rating of perceived exertion (OMNI scale) will be measured at the end of each bout and after active recovery. Subjects will have the option to request further monitoring if desired.
Study NCT04866628 — intervention group
Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Helichrysum italicum infusion
Description: Comparison of metabolic syndrome components before and after four weeks of daily consumption of Helichrysum italicum infusion.
Study NCT04866628 — intervention group
Intervention type: DIETARY_SUPPLEMENT
Group type: ACTIVE_COMPARATOR
Intervention: Helichrysum arenarium
Description: Comparison of metabolic syndrome components before and after four weeks of daily consumption of Helichrysum arenarium infusion.
Study NCT05892718 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: HCB101
Description: HCB101 administered via. intravenous (IV) infusion.
Study NCT05504486 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Brexpiprazole
Description: Oral tablet; take once daily; target daily dose of 2 mg
Study NCT05117281 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Levobupivacaine
Description: Plain, isobaric levobupivacaine (0.25%) 1 ml/kg
Study NCT05117281 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Levobupivacaine
Description: Plain, isobaric levobupivacaine (0.25%) 0.25 mg/kg
Study NCT05963607 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Weighted blanket
Description: A blanket sewn with extra weight in it.
Study NCT05963607 — intervention group
Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Weighted blanket
Description: A blanket sewn with extra weight in it.
Study NCT05115227 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Education
Description: The team will educate the patient about low back pain and how this can be self-managed.
Study NCT05115227 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Exercise
Description: The team will advice the patient to conduct relevant exercises and to stay physical active.
Study NCT05601622 — intervention group
Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Fluid loading
Description: Intravenous administration of 10ml/kg of crystalloids over 10 minutes
Study NCT05601622 — intervention group
Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Transthoracic echocardiography
Description: Transthoracic echocardiographic measurement of stroke volume index
Study NCT05601622 — intervention group
Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: PVI, RPVI
Description: Continuous measurement of pleth variability index and Rainbow pleth variability index
Study NCT05601622 — intervention group
Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Tidal volume change
Description: Changing tidal volume for mechanical ventilation as 6, 8, 10 ml/kg
Study NCT05204160 — intervention group
Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Pembrolizumab
Description: Given IV
Study NCT04804748 — intervention group
Intervention type: OTHER
Intervention: No intervention
Description: no intervention
Study NCT05380284 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Senior Driving Simulation Training
Description: The experimental group (Senior Driving Simulation Training: 30-mins training session two times per week for 5 weeks, with a total of 10 sessions) .
Study NCT05380284 — intervention group
Intervention type: OTHER
Group type: OTHER
Intervention: Waiting list control
Description: The control group is waiting list control. They will also receive the (Senior Driving Simulation Training) after all research is done.
Study NCT04351373 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Fluorescein Sodium
Description: Intravenous administration 1 mg/kg initial dosing if insufficient additional doses of 1 mg/kg may be administered.
Study NCT04351373 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: YELLOW560 filter
Description: Integrated fluorescence module serves to make fluorescent areas visible to assist in visualizing tumor during the resection.
Study NCT05441111 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Common Elements Toolbox
Description: COMET consists of the following modules: cognitive restructuring (labeled flexible thinking), behavioral activation (labeled positive activities), gratitude, and self-compassion. Participants complete these COMET modules by themselves. The format is reading psychoeducational along with completing specific activities
Study NCT05441111 — intervention group
Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Common Elements Toolbox
Description: COMET consists of the following modules: cognitive restructuring (labeled flexible thinking), behavioral activation (labeled positive activities), gratitude, and self-compassion. Participants complete these COMET modules by themselves. The format is reading psychoeducational along with completing specific activities
Study NCT05441111 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Doing What Matters in Times of Stress: An Illustrated Guide
Description: From the WHO's website: Doing What Matters in Times of Stress: An Illustrated Guide is a stress management guide for coping with adversity. The guide aims to equip people with practical skills to help cope with stress. A few minutes each day are enough to practice the self-help techniques. The guide can be used alone or with the accompanying audio exercises.~Informed by evidence and extensive field testing, the guide is for anyone who experiences stress, wherever they live and whatever their circumstances.
Study NCT05441111 — intervention group
Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Doing What Matters in Times of Stress: An Illustrated Guide
Description: From the WHO's website: Doing What Matters in Times of Stress: An Illustrated Guide is a stress management guide for coping with adversity. The guide aims to equip people with practical skills to help cope with stress. A few minutes each day are enough to practice the self-help techniques. The guide can be used alone or with the accompanying audio exercises.~Informed by evidence and extensive field testing, the guide is for anyone who experiences stress, wherever they live and whatever their circumstances.
Study NCT05441111 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Guided self-help
Description: Participants in the guided self-help condition are assigned an eCoach who provides emotional support as well as who promote adherence to the intervention
Study NCT06622564 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Before CPB Tranexamic Acid
Description: Tranexamic acid 1 to 10 g (10 to 100 mL) administered intravenously as per standard care at the induction of anesthesia as a bolus and/or continuous infusion (i.e., before CPB).
Study NCT06622564 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: After CPB Tranexamic Acid
Description: Tranexamic acid 5 g (50 mL) administered after heparin reversal (i.e., after CPB).
Study NCT06622564 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Before CPB Placebo
Description: Placebo (10 to 100 mL saline) administered intravenously at the induction of anesthesia as a bolus and/or continuous infusion.
Study NCT06622564 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: After CPB Placebo
Description: Placebo (50 mL saline) administered after heparin reversal.
Study NCT06622603 — intervention group
Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Febuxostat
Description: The minimal approved dose of febuxostat is 40 mg/day. We will use 0.5 tablet of febuxostat 40 mg or its placebo.
Study NCT06622603 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Febuxostat
Description: The minimal approved dose of febuxostat is 40 mg/day. We will use 0.5 tablet of febuxostat 40 mg or its placebo.
Study NCT06184945 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Realtime audit and feedback
Description: ICUs randomized to this arm will receive and electronic dashboard that displays realtime ABCDEF bundle performance data