AIM-Harvard/TrialPanorama-filtered huggingface dataset:
Study NCT05945212 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Fugl-Meyer (FMA-LE)
Description: The Fugl-Meyer (FMA-LE) assessment of motor skills : measurement of the intensity of reflexes, as well as an assessment of voluntary movements and motor coordination. Score from 0 to 34
Study NCT05945212 — intervention group
Intervention type: OTHER
Group type: SHAM_COMPARATOR
Intervention: Fugl-Meyer (FMA-LE)
Description: The Fugl-Meyer (FMA-LE) assessment of motor skills : measurement of the intensity of reflexes, as well as an assessment of voluntary movements and motor coordination. Score from 0 to 34
Study NCT05945212 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Modified Ashworth scale
Description: The modified Ashworth scale allows the measurement of spasticity, that is to say the measurement of muscle tone by mobilizing the segment of the lower limb and by evaluating the resistance to stretching of the muscles. Score from 0 to 4
Study NCT05945212 — intervention group
Intervention type: OTHER
Group type: SHAM_COMPARATOR
Intervention: Modified Ashworth scale
Description: The modified Ashworth scale allows the measurement of spasticity, that is to say the measurement of muscle tone by mobilizing the segment of the lower limb and by evaluating the resistance to stretching of the muscles. Score from 0 to 4
Study NCT05945212 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: ABILOCO questionnaire
Description: The ABILOCO questionnaire evaluate the autonomy in the walking capacities of the patients (13-items)
Study NCT05945212 — intervention group
Intervention type: OTHER
Group type: SHAM_COMPARATOR
Intervention: ABILOCO questionnaire
Description: The ABILOCO questionnaire evaluate the autonomy in the walking capacities of the patients (13-items)
Study NCT05945212 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Barthel index
Description: The Barthel index measure autonomy in daily life.
Study NCT05945212 — intervention group
Intervention type: OTHER
Group type: SHAM_COMPARATOR
Intervention: Barthel index
Description: The Barthel index measure autonomy in daily life.
Study NCT05945212 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: isometric ergometer
Description: Evaluate voluntary maximum force in isometric ankle dorsiflexion by Cybex isometric ergometer results.
Study NCT05945212 — intervention group
Intervention type: OTHER
Group type: SHAM_COMPARATOR
Intervention: isometric ergometer
Description: Evaluate voluntary maximum force in isometric ankle dorsiflexion by Cybex isometric ergometer results.
Study NCT05945212 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Electromyograms (EMG)
Description: Assessment of neuromuscular fatigue by electromyograms (EMG). Surface electrodes is place on the tibial muscle anterior to non-invasively collect electromyograms (EMG). The intensity of stimulation will be gradually increased until a plateau in mechanical (strength) and electromyograms (EMG) responses is obtained.
Study NCT05945212 — intervention group
Intervention type: OTHER
Group type: SHAM_COMPARATOR
Intervention: Electromyograms (EMG)
Description: Assessment of neuromuscular fatigue by electromyograms (EMG). Surface electrodes is place on the tibial muscle anterior to non-invasively collect electromyograms (EMG). The intensity of stimulation will be gradually increased until a plateau in mechanical (strength) and electromyograms (EMG) responses is obtained.
Study NCT05945212 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Traditional quantified gait analysis
Description: Gait kinematics will be recorded on a force platform (90 x 90 cm, Model 9287C, Kistler, Winterthur, Switzerland) to determine: joint angles, net joint moments and powers at the ankle, knee and hip.
Study NCT05945212 — intervention group
Intervention type: OTHER
Group type: SHAM_COMPARATOR
Intervention: Traditional quantified gait analysis
Description: Gait kinematics will be recorded on a force platform (90 x 90 cm, Model 9287C, Kistler, Winterthur, Switzerland) to determine: joint angles, net joint moments and powers at the ankle, knee and hip.
Study NCT05781867 — intervention group
Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Manual therapy and conventional physical therapy treatment
Description: manual therapy (chest mobilization, diaphragmatic myofascial release, myofascial release for pectoralis minor, pectoralis major, scaleni ),pursed lip breathing, diaphragmatic breathing and active range of motion exercises of upper limbs
Study NCT05781867 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Manual therapy and conventional physical therapy treatment
Description: manual therapy (chest mobilization, diaphragmatic myofascial release, myofascial release for pectoralis minor, pectoralis major, scaleni ),pursed lip breathing, diaphragmatic breathing and active range of motion exercises of upper limbs
Study NCT05945212 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: SPM - Statistical Parametric Mapping
Description: Addition of a temporal component to the traditional quantified gait analysis, allowing the focus to be on time series parameters.
Study NCT05945212 — intervention group
Intervention type: OTHER
Group type: SHAM_COMPARATOR
Intervention: SPM - Statistical Parametric Mapping
Description: Addition of a temporal component to the traditional quantified gait analysis, allowing the focus to be on time series parameters.
Study NCT05945212 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: FACIT questionnaire (Functional Assessment of Chronic Illness Therapy)
Description: A short questionnaire consisting of 13 questions to which the patient answers on a scale from 0 to 4. The scores are simply added up, inverting the scale for negative sentences, to give a result out of 52 points. The lower the score, the greater the fatigue.
Study NCT05945212 — intervention group
Intervention type: OTHER
Group type: SHAM_COMPARATOR
Intervention: FACIT questionnaire (Functional Assessment of Chronic Illness Therapy)
Description: A short questionnaire consisting of 13 questions to which the patient answers on a scale from 0 to 4. The scores are simply added up, inverting the scale for negative sentences, to give a result out of 52 points. The lower the score, the greater the fatigue.
Study NCT05353088 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: scapular stabilization
Description: Scapular stabilization exercise aims to restore scapular position, orientations, motor control of muscles, and movement pattern, thereby attaining stability of scapula for better kinematics of shoulder.scapular stabilization exercises for 4 weeks with 2 sets of 10 repetitions. These exercises comprised of four exercise programs (Scapular retraction; Scapular mobilization, Scapular dynamic stabilization I and Scapular dynamic stabilization II)
Study NCT05353088 — intervention group
Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Thoracic extension exercises
Description: Thoracic extension involves concurrent posterior rotation (external torsion) and depression of the posterior ribs with elevation of the anterior ribs. Bending to the side is a combination of spinal segments side bending, ribs on the same come together while ribs on the opposite side separate.Group B performed thoracic extension exercises for 4 weeks with 2 sets of 10 repetitions. These exercises comprised of three exercise programs.
Study NCT04835545 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: extreme hypercapnia induced by ventilation insufficiency
Description: extreme hypercapnia
Study NCT04925102 — intervention group
Intervention type: OTHER
Intervention: Standardized treatment protocol for cerebral palsy
Description: Passive and active range of motion (ROM) exercises of all joints, prone positioning, slow prolonged manual stretching (30 minutes daily), standing frame for children with GMFCS IV-V, supported sitting, supported walking, lower limb serial casting (if needed), active strength training, progressive resistance training, functional exercises, sensory integration: therapeutic activities to organize sensation from the body and environment, bimanual training: repetitive task training in the use of two hands together, context-focused therapy: changing the task or the environment, the occupational therapy, cognitive behaviour therapy and home programmes.
Study NCT05514730 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Phase-based Treatment (PBT) for Problematic Sexual Behavior of Preteen Children
Description: PBT is a skills-based protocol that primarily works with caregivers to manage problematic behavior and to teach children healthy information about sex and sexuality. It was designed based on the current empirical knowledge regarding the etiology and treatment of childhood problematic sexual behavior. It is delivered in 12 weekly sessions, with each session lasting approximately 50 minutes.
Study NCT05514730 — intervention group
Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Treatment-as-Usual (TAU)
Description: The TAU intervention designed for this trial relies largely on the delivery of child-focused treatment techniques, particularly on the development of therapeutic rapport through the utilization of non-directive techniques. These sessions are supplemented with educational materials for the caregiver on child behavior and parenting recommendations. This treatment is designed to be administered over 12 weekly sessions, with each session lasting approximately 50 minutes.
Study NCT04817306 — intervention group
Intervention type: DEVICE
Intervention: Multi-cancer early detection test
Description: Blood collection and multi-cancer early detection testing
Study NCT05401994 — intervention group
Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: screw retained arch bar
Description: maxillomandibular fixation with bone screwed arch bar
Study NCT05401994 — intervention group
Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: conventional Erich's Arch Bar
Description: maxillomandibular fixation with conventional arch bar fixed to the teeth
Study NCT05554107 — intervention group
Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Training program
Description: A 16-week training program consisting of 2-3 visits per week, and 60 minutes per visit. The program will be done as group exercise under supervision from physiotherapists and/or physicians with special interest in POTS.
Study NCT05982795 — intervention group
Intervention type: OTHER
Intervention: Nasal endoscopy with microbiome swab and mucus collection through filter paper and sponge
Description: A CultureSwab MaxV(+) (BD, Franklin Lakes, NJ) will be placed under endoscopic visualization to the middle meatus through a sterile sheath (red rubber urinary catheter) and gently rotated 5 full turns or until the tip is saturated with mucus (no more than 20 seconds).~Under direct visualization, a sterile Leukosorb sponge (Leukosorb; Pall Scientific, Port Washington, NY) will be placed in the middle meatus. A piece of Leukosorb filter paper will additionally be placed in the olfactory cleft. The sponge and paper will be left for 5 minutes and will then be removed under direct visualization and collected for analysis.
Study NCT05982795 — intervention group
Intervention type: OTHER
Intervention: Olfactory Function Testing
Description: Olfactory function will be tested using the Sniffin' Sticks extended test kit (MediSense, NL) using the established threshold, discrimination, and identification (TDI) scoring system. Odors will be delivered using felt-tip pens (Sniffin' Sticks, MediSense, NL). The pen cap will be removed from the pen for approximately 3 seconds, and the pen's tip will be brought in front of the subject's nose and carefully moved from left to right nostril. Threshold testing will be obtained by asking the subject to identify the pen containing the odor from two pens containing only solvent. This will be conducted starting with the lowest concentration of odor and moving stepwise until patient is no longer able to identify the odor from the solvent.~Subjects may also be asked to complete the University of Pennsylvania Smell Identification Test (UPSIT). The UPSIT can be self-administered and uses microencapsulated odorants which are released by scratching standardized odor-impregnated test booklets.
Study NCT05982795 — intervention group
Intervention type: OTHER
Intervention: Survey Completion
Description: Participants will be asked to complete the validated Cystic Fibrosis Questionnaire-Revised (CFQ-R) survey. This survey evaluates Cystic Fibrosis-specific and general quality of life metrics.~Participants will also be asked to complete the validated Sino-nasal Outcome Test-22 (SNOT-22) which is the most commonly used survey for evaluating outcomes in patients with chronic rhinosinusitis.~Participants will also be asked to complete the validated Sinus Control Test (SCT) - a 4-question questionnaire that assesses disease control in chronic rhinosinusitis.~Participants will be asked to complete the questionnaire of olfactory disorders (QOD). This is a 25-question validated survey used to assess the impact of olfactory dysfunction on patients with sinonasal disease.
Study NCT06412354 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: EasyCross™ first-in human
Description: At T0 the patient will undergo the TAVR procedure including the investigational procedure with the VIVHEART EasyCross™ catheter.~The interventional cardiologist will introduce the VIVHEART EasyCross™ catheter through the femoral artery with a percutaneous access according to the clinical practice through a vascular introducer on an already positioned guidewire. An operator in the procedure room will start a chronometer at this point to measure the investigational device crossing procedure duration.~The VIVHEART EasyCross™ catheter will be progressed into the aorta and up to the aortic valve.~At that time the external part of the VIVHEART EasyCross™ catheter will be opened to allow the self-centering of the catheter on the aortic valve. The guidewire will be introduced and once having crossed the valve the VIVHEART EasyCross™ catheter will be retracted by the physician and removed from the patient's body.
Study NCT04777201 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Faricimab
Description: Faricimab 6 mg will be administered by intravitreal (IVT) injection into the study eye according to the personalized treatment interval (PTI) dosing regimen for the duration of the study.
Study NCT04777201 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Sham Procedure
Description: The sham is a procedure that mimics an IVT injection and involves the blunt end of an empty syringe (without a needle) being pressed against the anesthetized eye. The sham procedure will be administered to participants as appropriate during the first 12 weeks of this study in order to maintain the masking of the initial faricimab PTI.
Study NCT05695586 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Mindful Self-Compassion (MSC) training
Description: 8-week Mindful Self-Compassion (MSC) intervention protocol, developed by Germer and Neff (2013, 2019). After the training, participants will enter a 12-month phase of regular MSC-based supervised practice.
Study NCT05695586 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Mindfulness Based Stress Reduction (MBSR) training
Description: 8-week Mindfulness Based Stress Reduction (MBSR) intervention protocol, as developed by Stahl \& Goldstein (2010). After the training, participants will enter a 12-month phase of regular MBSR-based supervised practice.
Study NCT06254612 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: SP-624
Description: Once daily oral administration of two capsules totaling 20 mg/day
Study NCT06254612 — intervention group
Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Once daily oral administration of two matching placebo capsules
Study NCT05867277 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: music
Description: The students in the intervention group listened to music for 15 min before and during the peripheral intravenous catheter placement skill practice.
Study NCT05963347 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Golidocitinib
Description: Daily dose. Starting dose of golidocitinib is 75 mg QD. If tolerated, subsequent cohorts will test ascending doses of golidocitinib.
Study NCT05963347 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: CHOP Regimen
Description: CHOP will be administered in a 21-day cycle for a maximum of 6 cycles.
Study NCT05121558 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Yoga
Description: Participants will have instructional yoga classes twice each week over the course of 8 weeks. Each yoga class will be 60 minutes, and it will be taught by an experienced yoga instructor. Participants will be provided with a home-based guided program for days classes are not held. Participants in the yoga group will also have the option to participate in a recorded final check-in session after they have completed their 16 yoga classes. The discussion facilitator will follow the Semi-Structured Interview Guide to further understand participants' experiences in the yoga group.
Study NCT05121558 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Education control
Description: Participants will have educational sessions over 8 weeks. The sessions will be on the causes and impact of Chemotherapy-Induced Peripheral Neuropathy (CIPN), how yoga may help with CIPN, and how different therapies may help with CIPN. To encourage participation and adherence, patients in the EC group will receive sixteen free yoga sessions after completing the study. Patients in the EC group will be asked to not go for their own yoga classes locally until their participation in the study is completed.
Study NCT05121558 — intervention group
Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Usual care
Description: Participants in the usual care control group will complete the same assessments as the other two arms. To encourage participation and adherence, patients in the UC group will receive sixteen free yoga sessions after completing the study. Patients in the UC group will be asked to not go for their own yoga classes locally until their participation in the study is completed.
Study NCT05937893 — intervention group
Intervention type: OTHER
Group type: OTHER
Intervention: Keto-ester followed by Magnetic Resonance Spectroscopic Imaging (MRSI) scans
Description: Following baseline scans, the participant will orally consume the keto-ester, for subsequent scans which will include repeated BHB MRSI acquisitions to dynamically measure BHB labeling in the brain, followed by a final GABA MRSI acquisition.
Study NCT05779449 — intervention group
Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Prebiotics and Probiotics supplementation
Description: From the 1st day to the 15th day (included) patients with MS in the Pre-Pro group will receive daily:~1 capsule of Probactiol Duo, Metagenics (6 billions of Saccharomyces boulardii and 8,5 billions of probiotics including Bifidobacterium lactis Bi-07®, Bifidobacterium lactis Bl-04, Lacticaseibacillus paracasei Lpc-37, Lactobacillus acidophilus NCFM®)~1. packet of Probactiol Stips, Metagenics (4 g inulin enriched with oligofructose)~   From the16th day to the 365th day (included) patients with MS in the Pre-Pro group will receive daily:~2. capsules of Probactiol HMO Combi, Metagenics (7,5 billions of Lactobacillus acidophilus NCFM®, 7,5 billions of Bifidobacterium lactis Bi-07®, 2,5 ug Vitamine D3, 320 ug Vitamine A, 100 mg Threonine, 250 mg 2'-Fucosyllactose).
Study NCT05779449 — intervention group
Intervention type: DIETARY_SUPPLEMENT
Group type: PLACEBO_COMPARATOR
Intervention: Placebo supplementation
Description: 1-year supplementation with two placebo capsules/day containing starch, the probiotic bacteria carrier.
Study NCT05779449 — intervention group
Intervention type: PROCEDURE
Group type: PLACEBO_COMPARATOR
Intervention: peripheral blood withdrawal
Description: 40 ml of blood for the isolation of Peripheral Blood Cells (PBMCs) and T cells.
Study NCT05779449 — intervention group
Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: peripheral blood withdrawal
Description: 40 ml of blood for the isolation of Peripheral Blood Cells (PBMCs) and T cells.
Study NCT05779449 — intervention group
Intervention type: PROCEDURE
Group type: PLACEBO_COMPARATOR
Intervention: Transcranial Magnetic Stimulation (TMS)
Description: Intermittent theta burst stimulation (iTBS) protocol
Study NCT05779449 — intervention group
Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Transcranial Magnetic Stimulation (TMS)
Description: Intermittent theta burst stimulation (iTBS) protocol
Study NCT05984771 — intervention group
Intervention type: DIETARY_SUPPLEMENT
Group type: ACTIVE_COMPARATOR
Intervention: Epineuron
Description: Superoxide Dismutase (SOD, 70 UI), Palmitoylethanolamide (PEA, 300 mg) Alpha Lipoic Acid (ALA, 300 mg), vitamins B6 (1.5 mg), B1 (1.1 mg), B12 (2.5 mcg), E (7.5 mg), Nicotinamide (9 mg) and minerals (Mg 30 mg, Zn 2,5 mg) in one tablet (Epineuron)
Study NCT05984771 — intervention group
Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Placebo group
Description: Usual care
Study NCT04963088 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: BGB-A317
Description: Subjects will be treated with BGB A317 200 mg IV on Day 1 during each 21-day cycle. BGB A317 will be administered until disease progression, intolerable toxicity, or treatment discontinuation for any other reason
Study NCT04963088 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Anlotinib
Description: oral administration daily d1-d14, q3w;
Study NCT04963088 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Oxaliplatin
Description: 30 mg/m² IV on Day 1 during each 21-day cycle. during each 21-day cycle
Study NCT04963088 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Capecitabine
Description: 1000 mg/m² orally twice daily (bid) Days 1 through 14 (14 days total) during each 21-day cycle. Capecitabine will be administered until disease progression, intolerable toxicity, or treatment discontinuation for any other reason.
Study NCT05333523 — intervention group
Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: Sentinel lymph node biopsy guided selective elective neck irradiation
Description: Patients will undergo sentinel lymph node biopsy. Based on the histopathologic status of the sentinel lymph node(s), selective elective neck irradiation is performed with standard radiation treatment of the primary tumor.~There are 3 possible treatment scenarios.~1. Bilateral elective neck irradiation is indicated when sentinel lymph nodes at both sides of the neck contain metastases or when sentinel lymph node detection fails.~2. Unilateral elective neck irradiation is indicated when sentinel lymph node(s) at one side of the neck contain metastases.~3. Full omission of elective neck irradiation is indicated when all sentinel lymph nodes are free of metastases.