AIM-Harvard/TrialPanorama-filtered huggingface dataset:
Study NCT06417268 — intervention group
Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Caudal epidural analgesia
Description: patient will be placed in the left lateral position with flexed hips.After palpating the landmarks (the upper posterior iliac spine and sacral hiatus from the edges of an equilateral triangle), an epidural puncture is performed in the most proximal region of the sacral hiatus with the needle inclined 45-60° to the skin. While palpating with the index finger of the left hand, the needle is inserted immediately below the spinous process S4.~After perforating the membrane, the needle will be advanced no more than 1-3 mm to avoid a bloody puncture or an intrathecal injection, The confirmation of the correct position of the caudal needle before injection by performing the modified 'swoosh' test performed by auscultation at the thoracolumbar region with a stethoscope while injecting 2 mL of saline. Bupivacaine 0.25% at a dose of 1 ml/kg will be injected, with care taken not to exceed the maximum recommended dose (2 mg/kg).
Study NCT06417268 — intervention group
Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Ultrasound-guided Combined Pericapsular Nerve Group Block
Description: With supine position, the probe will be put in a transverse plane along the anterior inferior iliac spine (AIIS) to identify the iliopsoas muscle, femoral nerve, and femoral artery (FA).~Then the probe will be rotated counter clockwise to align with the pubic ramus to visualize the AIIS, iliopsoas prominence (IPE), FA, iliopsoas, and iliopsoas notch.~Under direct vision, a 22-gauge, 50-mm echo needle will be advanced in the lateral-medial plane between the psoas tendon and the pubic ramus until the needle tip touches the IPE. The needle will be withdrawn, and after negative aspiration, 1 ml/kg (Bupivacaine 0.25%) is injected
Study NCT06417268 — intervention group
Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Ultrasound-guided Lateral Femoral Cutaneous Nerve Block
Description: patient remains supine, and the transducer is parallel to the inguinal ligament. With the femoral artery and vein as guidance, the lateral part of the sartorius muscle and fascia lata is visualized. Approximately 3 cm inferior from this point, the branches of the lateral femoral cutaneous nerve are visualized in the hypoechoic fat-filled subfascial space between the sartorius muscle medially and the tensor fascia lata muscle laterally. A 22-gauge, 50-mm needle is inserted with in plane approach at a shallow angle to reach the area of the nerve and after negative aspiration, 0.1 ml/kg (Bupivacaine 0.25%) is injected.
Study NCT06417268 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Fentanyl
Description: patients will receive an induction dose at 1 mcg/kg. If the analgesia was inadequate in the form of increase in heart rate and or arterial blood pressure by more than 20% of baseline values during surgery, this warrants the administration of intravenous fentanyl (0.5µg/kg).
Study NCT06417268 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Morphine
Description: If a FLACC pain Score is ≥ 4/10, the patient in the PACU will receive morphine (intravenous, 0.03 mg/kg), and the maximum allowed dose is 0.1mg/kg every 4 hours.
Study NCT06417268 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Acetaminophen
Description: P atients will receive postoperative IV acetaminophen IV 10 mg/ kg q 6 hours
Study NCT06213415 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Corticosteroid
Description: Oral steroids plus intratympanic injection
Study NCT04236531 — intervention group
Intervention type: OTHER
Group type: SHAM_COMPARATOR
Intervention: Cognitive tests and neuroimaging
Description: comparison of cognitive performances and brain anatomy
Study NCT04236531 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Cognitive tests and neuroimaging
Description: comparison of cognitive performances and brain anatomy
Study NCT05905679 — intervention group
Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Dietary Supplement: Probiotics
Description: 6 Billion CFU
Study NCT05905679 — intervention group
Intervention type: DIETARY_SUPPLEMENT
Group type: ACTIVE_COMPARATOR
Intervention: Dietary Supplement: Placebo
Description: 0 CFU per day
Study NCT05525286 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: SOT102
Description: SOT102 is an antibody-drug conjugate (ADC) targeting CLDN18.2 with the anthracycline PNU as cytotoxic moiety.
Study NCT06000046 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Automatic image analysis
Description: After referral for suspected prostate cancer, the patient is scanned with magnetic resonance imaging (MRI) in accordance with guidelines of the standardized healthcare pathway. For consenting patients, the images are interpreted in two ways: first, in the conventional manner, i.e., manually by a radiologist, to determine whether clinically significant cancer is suspected. If so, the radiologist will delineate the suspicious lesions. In the second approach, the software will perform the same task as the radiologist, but automatically. If either or both interpretations point to significant cancer, the patient will be sent for targeted biopsy sampling. Histopathologic evaluation of the samples will then determine whether significant cancer is present in each of the targeted lesions (delineated by the radiologist, software, or both).
Study NCT05063487 — intervention group
Intervention type: OTHER
Intervention: Return of recent classification
Description: As part of routine HIV case-based surveillance in Rwanda, blood samples are collected for recency testing on the Rapid Test for Recent Infection (RTRI) assay and viral load testing for all newly diagnosed people living with HIV. Results of a recent classification (i.e., having acquired an HIV infection within the last year) will be returned to study participants during a scheduled 1-month visit following initial HIV diagnosis.
Study NCT05063487 — intervention group
Intervention type: OTHER
Intervention: Return of long-term classification
Description: As part of routine HIV case-based surveillance in Rwanda, blood samples are collected for recency testing on the Rapid Test for Recent Infection (RTRI) assay and viral load testing for all newly diagnosed people living with HIV. Results of a long-term classification (i.e., having acquired an HIV infection more than one year ago) will be returned to study participants during the scheduled 1-month visit following initial HIV diagnosis.
Study NCT05541276 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Melatonin
Description: Melatonin for injection 1 mg/mL
Study NCT05541276 — intervention group
Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Isotonic sodium chloride solution
Description: Sodium chloride 0.9 % for injection
Study NCT05537961 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Mindfulness-Oriented Recovery Enhancement
Description: Mindfulness instruction incorporated in classroom-based curriculum
Study NCT04921410 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Biofeedback Knee Sleeve
Description: The biofeedback knee sleeve is a device that is artificially-intelligent and utilizes determined cut-off values of knee motion and forces to determine whether a motion is 'good' or 'bad'. A 'bad' knee motion will provide a haptic output to the wearer (biofeedback) so that they can take note of what the previous motion was that caused the device to signal a warning.
Study NCT04842877 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Valemetostat tosylate
Description: 200mg QD continuously until disease progression, consent withdrawal, unacceptable drug-related toxicity, lost to follow-up, major protocol deviation, pregnancy, termination by sponsor or death, whichever occurs first.
Study NCT04921410 — intervention group
Intervention type: DEVICE
Group type: SHAM_COMPARATOR
Intervention: Sham Biofeedback
Description: The biofeedback knee sleeve is a device that is artificially-intelligent and utilizes determined cut-off values of knee motion and forces to determine whether a motion is 'good' or 'bad'. This intervention will provide sham biofeedback during training sessions.
Study NCT04819074 — intervention group
Intervention type: PROCEDURE
Intervention: Microsurgery
Description: Microsurgery for unruptured intracranial aneurysm
Study NCT04969627 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Metformin
Description: Use Metformin for 3 months to treat PCOS
Study NCT04969627 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Metformin
Description: Use Metformin for 3 months to treat PCOS
Study NCT04969627 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Exenatide
Description: Use Exenatide for 3 months to treat PCOS
Study NCT05641519 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: SERVE OC Intervention
Description: SERVE OC intervention for the family which includes 1) Conducting a family intake of risk factors through the LE8 assessment and discussing prevention/risk reduction 2) Facilitate the creation of a family network-tailored action plan 3) Provide guidance to activate/reinforce action plans using the interactive part of the app/web portal. They will meet with their CHW monthly to learn about CVH, work on their goals, and action plans. Meetings with CHWs will take place in their homes, the UCI FQHC in Santa Ana, over zoom, or other locations such as local churches, parks, community centers, or grocery stores (for field trips) They will also receive messages from them throughout the duration of the study using their preferred method of contact (text, email, webportal/app, phone call) for reinforcement and scheduling meetings
Study NCT05641519 — intervention group
Intervention type: BEHAVIORAL
Group type: PLACEBO_COMPARATOR
Intervention: Enhanced Standard Intervention
Description: Enhanced Standard Intervention will be given informational materials from the American Heart Association on cardiovascular health. ESI includes self-management which is standard care
Study NCT04404296 — intervention group
Intervention type: DEVICE
Group type: OTHER
Intervention: 25-gauge, bevel-tip, 20000 cut per minute pars plana vitrectomy
Description: Pars plana vitrectomy using 25-gauge, bevel-tip, 20000 cut per minute vitrectomy probe
Study NCT04866225 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Oral [14C]PF-06865571
Description: Oral radiolabeled PF-06865571
Study NCT04866225 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Oral PF-06865571
Description: Oral PF-06865571
Study NCT04866225 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: IV [14C]PF-06865571
Description: IV radiolabeled PF-06865571
Study NCT04344392 — intervention group
Intervention type: DIAGNOSTIC_TEST
Group type: OTHER
Intervention: Ultrasonographic study
Description: Thyroid hyoid approximation and hyoid anterior replacement during swallowing. Tongue thickness in rest.
Study NCT06196710 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Over-the-scope Clips
Description: Over-the-scope Clips is mounted onto a transparent cap, which is attached to the tip of the endoscope. To deploy the claw device, a cogwheel at the scope head is turned pulling a trip string. This in turn retracts the cap releasing the OTSC onto the vessels.
Study NCT06196710 — intervention group
Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Hemo-clipping
Description: Contact thermocoagulation using a 3.3mm probe, hemo-clips, or both. The use of the bipolar device involves firm mechanical compression and coagulation for about 8 seconds.
Study NCT06341647 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: AB-201
Description: NK Cell Therapy
Study NCT06341647 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Cyclophosphamide
Description: Lymphodepleting chemotherapy
Study NCT06341647 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Fludarabine
Description: Lymphodepleting chemotherapy
Study NCT05388474 — intervention group
Intervention type: OTHER
Intervention: No ibalizumab or Pre-ibalizumab treatment
Description: Patient registry
Study NCT05258513 — intervention group
Intervention type: DIETARY_SUPPLEMENT
Group type: PLACEBO_COMPARATOR
Intervention: Placebo Supplementation
Description: 8 weeks of placebo supplementation
Study NCT05258513 — intervention group
Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: GG sourced from Annatto
Description: 8-weeks of Geranylgeraniol supplementation
Study NCT04985513 — intervention group
Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Ventilation during cardiopulmonary bypass
Description: Ventilation was performed using an inhaled oxygen fraction of 20% and a tidal volume of 5ml/kg at the time of cardiopulmonary bypass.
Study NCT04344392 — intervention group
Intervention type: DIAGNOSTIC_TEST
Group type: OTHER
Intervention: Videofluoroscopic study temporal parameters
Description: Glossopalatine junction opening and closing time, velopharyngeal junction opening and closing time, laryngeal vestibule opening and closing time, upper esophageal sphincter opening and closing time in seconds.
Study NCT04344392 — intervention group
Intervention type: DIAGNOSTIC_TEST
Group type: OTHER
Intervention: Videofluoroscopic study distance parameters
Description: Hyoid bone horizontal and vertical replacement, thyroid-hyoid approximation (THA) in millimeters.
Study NCT03459547 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: dental implant
Description: Local anesthesia, flap preparation, dental implant insertion, flap suture, healing abutment insertion. Peri-implant soft tissue samples taken prior to implant placement and 24 hours after.
Study NCT03459547 — intervention group
Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: dental implant
Description: Local anesthesia, flap preparation, dental implant insertion, flap suture, healing abutment insertion. Peri-implant soft tissue samples taken prior to implant placement and 24 hours after.
Study NCT04981769 — intervention group
Intervention type: DIAGNOSTIC_TEST
Intervention: Covid-19 test
Description: PCR Covid-19 test
Study NCT05388474 — intervention group
Intervention type: BIOLOGICAL
Intervention: On ibalizumab treatment
Description: Patient registry
Study NCT06310161 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Bright light
Description: Bright light treatment will consist of using the Re-timer device 3 times per week during dialysis sessions for 4 weeks. The Re-timer is worn like a pair of glasses and contains light emitting diodes mounted on the lower portion of the frame. The Re-timer emits blue-green 500 nm light with an intensity of \~500 lux lm/m2. Participants will be instructed to use the device for 60 minutes at the beginning of each dialysis session.
Study NCT06310161 — intervention group
Intervention type: DEVICE
Group type: PLACEBO_COMPARATOR
Intervention: Dim Light
Description: Dim light treatment will use non-light emitting glasses that look identical to Re-Timer for 4 weeks at each dialysis session following baseline assessments. Participants will use the device for 60 minutes at the beginning of their dialysis session.
Study NCT05452616 — intervention group
Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: ART first- Therapeutic use trial
Description: ART initiation on the day of enrolment independent of TB investigations in PLHIV with presumptive TB but no signs of CNS disease. The trial uses treatments and drug-doses as per international and national guidelines. All treatment components will be applied at standard dosage and no new substances or alternative indications will be tested.
Study NCT05452616 — intervention group
Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: TB results first- Therapeutic use trial
Description: Deferral of ART initiation until active TB has been refuted or confirmed. PLHIV presenting with symptoms (cough, fever, night sweat, weight loss) are defined as presumptive TB, and should have microbiological TB investigations. Routine TB investigations in Malawi and Lesotho usually consist of two sputum bottles for analysis using nucleic acid amplification tests (Xpert MTB/RIF (Ultra)).The trial uses treatments and drug-doses as per international and national guidelines. All treatment components will be applied at standard dosage and no new substances or alternative indications will be tested.
Study NCT05309369 — intervention group
Intervention type: BEHAVIORAL
Group type: PLACEBO_COMPARATOR
Intervention: Preferred Music
Description: Participants will listen to selected music using over-ear headphones delivered as 10-minute segments at the top of each hour over the course of 3 hours
Study NCT02630121 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Oxymetazoline Hydrochloride
Description: Proportion of the subjects with 50% reduction in AHI.
Study NCT02630121 — intervention group
Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Proportion of the subjects with 50% reduction in AHI.
Study NCT05309369 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Preferred Music
Description: Participants will listen to selected music using over-ear headphones delivered as 10-minute segments at the top of each hour over the course of 3 hours
Study NCT05309369 — intervention group
Intervention type: BEHAVIORAL
Group type: PLACEBO_COMPARATOR
Intervention: Nature Sounds
Description: Participants will listen to nature sounds using over-ear headphones delivered as 10-minute segments at the top of each hour over the course of 3 hours
Study NCT05309369 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Nature Sounds
Description: Participants will listen to nature sounds using over-ear headphones delivered as 10-minute segments at the top of each hour over the course of 3 hours
Study NCT05604404 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Supine
Description: The patient will be positioned supine with head-of-bed at zero degrees.
Study NCT05604404 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Semi-Recumbent
Description: The patient will be placed in a semi-recumbent position with head-of-bed at thirty degrees.
Study NCT05604404 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Semi-Recumbent with Legs Flexed
Description: The patient will be placed in a semi- recumbent position with head-of-bed at thirty degrees and legs flexed.
Study NCT06022900 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Online training group
Description: online health education with video call
Study NCT06022900 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Face-to-face training group
Description: Face-to-face health education with home visit
Study NCT05915975 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Behavioral Care Coordinated with Medical Care Intervention
Description: Participants will be meeting with a behavioral health provider during their clinic visit. Subsequent visits can be held either via telehealth or in-person. Participants should expect weekly visits during the first two months and less frequent visits (biweekly or monthly) for the last two months. Some sessions that are provided via telehealth might be video recorded and later reviewed to ensure that the program is being delivered as intended.
Study NCT05915975 — intervention group
Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Behavioral Care Not Coordinated with Medical Care Intervention
Description: Participants will meet with a study team member during their in-person visit and will receive a list of clinics that are panelled with their insurance. The participants will be responsible for calling the clinics to set up their appointments. Services might be provided in person or via telehealth based on the participant's preference and the clinics' availability.
Study NCT05500196 — intervention group
Intervention type: DEVICE
Intervention: Per Oral Endoscopy Myotomy (POEM)
Description: POEM is a form of natural orifice transluminal endoscopic surgery that is completed by creating a submucosal tunnel in the lower part of esophagus to reach the inner circular muscle bundles of the LES to perform myotomy, while preserving the outer longitudinal muscle bundles. The result is decreased resting pressure of the LES, facilitating the passage of ingested material.
Study NCT05486793 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Written Exposure Therapy (WET)
Description: 5 individual sessions that cover psychoeducation about PTSD, the rationale for exposure treatment, and directing patients to write in session for 30 minutes about their traumatic experience using scripted instructions. Each session includes unique writing instructions. Earlier sessions focus on describing the details of a traumatic stressor linked to their symptoms, with particular attention to felt emotions and thoughts. Later writing sessions focus on writing about the meaning of the traumatic event and how the event has changed their life and how they relate to other people. After writing, therapists spend \~10 minutes processing the patient's experience with the writing. WET does not include between session assignments.
Study NCT05486793 — intervention group
Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Emotion Focused Supportive Therapy (EFST)
Description: 5 individual sessions where patients choose what problems to discuss in each session. Therapists validate and clarify patients' emotions and engage in problem solving during sessions.
Study NCT04769336 — intervention group
Intervention type: DEVICE
Intervention: Central Lab based CBC
Description: lab samples will be sent to the central lab for CBC analysis
Study NCT06396767 — intervention group
Intervention type: DIAGNOSTIC_TEST
Intervention: DIA measured via Ultrasonography
Description: Ultrasound will be used to measure Diaphragmatic Inspiratory Amplitude (DIA) of patients before and after elective cardiac surgery to determine if there is a correlation between changes in DIA and postoperative pulmonary complications.
Study NCT04769336 — intervention group
Intervention type: DEVICE
Intervention: Point of Care CBC
Description: lab samples will be analyzed at point of care
Study NCT04767776 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Rivaroxaban
Description: rivaroxaban 40 mg/day (1 day).
Study NCT04767776 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Activated charcoal
Description: Activated charcoal 2 hours after rivaroxaban administration (1 day).
Study NCT04828850 — intervention group
Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Endobronchial ultrasound transbronchial needle aspiration lymph node staging
Description: EBUS-TBNA in clinical N0 NSCLC patients