AIM-Harvard/TrialPanorama-filtered huggingface dataset:
Study NCT04823741 — intervention group
Intervention type: GENETIC
Intervention: PLEURAL BIOCOLLECTION OF MALIGNANT PLEURAL MESOTHELIOMA
Description: All patient with suspected malignant pleural mesothelioma requiring surgical biopsy after validation in oncologic multidisciplinary board will be included. During a standardized routine procedure of pleural biopsy by mean of general anesthesia and video thoracoscopic approach, 3 - 5 biopsies are realized. During this procedure, blood samples are collected and a piece of biopsy will be used for the constitution of a specific bio collection in the CRB (centre de ressources biologiques).
Study NCT05549414 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Proton Radiation
Description: Proton beam radiotherapy, first proposed by Robert Wilson at Harvard University in 1946, utilizes an energetic beam of ionized hydrogen nuclei (protons) directed at the tumor volume to effect DNA damage of the targeted cells. Today, there are hundreds of proton treatment centers worldwide and it is considered standard treatment for certain malignancies and/or clinical scenarios
Study NCT06322017 — intervention group
Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Rhythm control by Pulmonary Vein Isolation (PVI) procedure
Description: The PVI procedure involves the creation of a circumferential lesion around the ostium of the four pulmonary veins.~The choice of the type of energy to insure the lesion will be left to the discretion of the investigator, according to the center's habits and the patient's anatomy found on the scanner.
Study NCT06322017 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Conventional care by antiarrhythmic drugs (flecainide, sotalol, amiodarone) or bradycardic drugs (all betablocker or calcium channel blocker therapy, digoxin)
Description: Ventricular rate control is carried out using negative chronotropic agents (e.g. beta-blockers, calcium channel blockers, digitalis, etc.) according to current recommendations. If this fails, ablation of the atrioventricular junction with placement of a permanent pacemaker can be carried out according to current recommendations. As part of this research, the choice of bradycardic drugs and interventions will be left to the discretion of the investigator according to the center's practices and current recommendations.~Rhythm control aims to reduce AF by cardioversion (if it persists) to restore sinus rhythm and subsequently maintain it by introducing anti-arrhythmic treatment. Several antiarrhythmic drugs (flecainide, sotalol or amiodarone) can be used in this setting. As part of this research, the choice of antiarrhythmic drugs will be left to the discretion of the investigator according to the center's practices and current recommendations.
Study NCT04573192 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: L19TNF
Description: Cohort 1: 10 µg /kg L19TNF i.v. plus 90 mg/m2 lomustine Cohort 2: 10 µg /kg L19TNF i.v. plus 110 mg/m2 lomustine Cohort 3: 13 µg /kg L19TNF i.v. plus 110 mg/m2 lomustine
Study NCT04573192 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Lomustine
Description: Cohort 1: 10 µg /kg L19TNF i.v. plus 90 mg/m2 lomustine Cohort 2: 10 µg /kg L19TNF i.v. plus 110 mg/m2 lomustine Cohort 3: 13 µg /kg L19TNF i.v. plus 110 mg/m2 lomustine
Study NCT05608798 — intervention group
Intervention type: DEVICE
Group type: OTHER
Intervention: ODI-Tech medical device
Description: The device captures and stores frames of the movement of blood in capillaries and spectra containing information on oxygen saturation. Proprietary software is used to analyse the obtained frames and spectra to calculate microvascular parameters such as functional capillary density and microvascular oxygen saturation.~ODI-Tech can be brought to the patient's bedside and operates non-invasively. The device parts are in contact with the patient for less than 5 minutes.
Study NCT05009914 — intervention group
Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: cardiac denervation
Description: Excision of Marshall ligament and Waterstone fat pad during CABG.
Study NCT04769063 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Kinesio Tape
Description: Gluteus medius facilitation and knee spiral taping techniques will be applied to treat dynamic knee valgus
Study NCT05259995 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Sustained Acoustic Medicine
Description: The SAM device emits continuous ultrasound at 3 megahertz (MHz) frequency and 0.132 watts/cm2 intensity delivering 18,720 Joules of ultrasound per 4 hour treatment.
Study NCT04737161 — intervention group
Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: T regulatory cells
Description: T regulatory cells isolated by immunomagnetic selection; donor cells collected through large volume apheresis.
Study NCT05180279 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: 7-day sleep lab
Description: Patients will stay in 7-day sleep lab where light exposure, diet, and activity will be closely monitored. They will have two unprepped flexible sigmoidoscopies with rectal biopsy collection and stool collection. Cycles will be shifted by 12h once on Day 3 of sleep lab and be discharged after an 8 hour sleep session on Day 7.
Study NCT05090098 — intervention group
Intervention type: OTHER
Intervention: None intervention
Description: None intervention
Study NCT05259995 — intervention group
Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Sustained Acoustic Medicine
Description: The SAM device emits continuous ultrasound at 3 megahertz (MHz) frequency and 0.132 watts/cm2 intensity delivering 18,720 Joules of ultrasound per 4 hour treatment.
Study NCT06169189 — intervention group
Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: global warming-climate change based education
Description: The experimental group will be given 8 weeks of global warming-climate change based training. No intervention will be applied to the control group.
Study NCT05345743 — intervention group
Intervention type: PROCEDURE
Intervention: Surgery
Description: All types of surgery requiring general anesthesia
Study NCT04953572 — intervention group
Intervention type: GENETIC
Group type: EXPERIMENTAL
Intervention: autologous peripheral blood mesenchymal stem cell
Description: Transplantation of autologous peripheral blood mesenchymal stem cell
Study NCT04953572 — intervention group
Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Microfracture
Description: Microfracture
Study NCT04953572 — intervention group
Intervention type: COMBINATION_PRODUCT
Group type: ACTIVE_COMPARATOR
Intervention: Microfracture + collagen membrane
Description: Microfracture plus collagen membrane transplantation
Study NCT04953572 — intervention group
Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Autologous osteochondral transplantation
Description: Autologous osteochondral transplantation
Study NCT05570500 — intervention group
Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Oral health education
Description: oral health education sessions that aims to improve both knowledge of primary school children regarding bacteria, caries, number of teeth, plaque formation and attitude of primary school children regarding tooth brushing techniques, number of times per day, dietary instructions to avoid dental caries.
Study NCT05570500 — intervention group
Intervention type: BEHAVIORAL
Group type: PLACEBO_COMPARATOR
Intervention: Oral health education
Description: oral health education sessions that aims to improve both knowledge of primary school children regarding bacteria, caries, number of teeth, plaque formation and attitude of primary school children regarding tooth brushing techniques, number of times per day, dietary instructions to avoid dental caries.
Study NCT05782491 — intervention group
Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Interscalene Block
Description: It is an ultrasound guided brachial plexus nerve block at roots/trunks used to anesthetize the shoulder and upper arm. Goal is to spread local anesthetic around superior and middle trunks of brachial plexus, between the anterior and middle scalene muscles.
Study NCT05782491 — intervention group
Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: PECS II Block
Description: PECS II block is comprised of two separate fascial plane blocks to anesthetize anterolateral chest wall using an ultrasound guided injection between the pectoralis major muscle and pectoralis minor muscle at third rib and a second ultrasound guided injection between pectoralis minor and serratus anterior. The goal is a high volume hydro dissection of the two fascial planes to anesthetize anterolateral chest wall and axilla.
Study NCT05782491 — intervention group
Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Superficial Cervical Plexus Block
Description: This block is a superficial injection to the deep cervical fascia between the investing layer of the deep cervical fascia and the prevertebral fascia in the neck. This block provides anesthesia of the skin of the anterolateral neck and the ante-auricular and retro-auricular areas, as well as the skin overlying and immediately inferior to the clavicle on the chest wall. This is an ultrasound guided injection with the goal of placing the needle tip in the fascial layer underneath the SCM adjacent to the cervical plexus, which is contained within the tissue space between the Cervical fascia and posterior sheath of the SCM.
Study NCT04805424 — intervention group
Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Lipo-abdominoplasty
Description: Abdominoplasty plus liposuction
Study NCT04805424 — intervention group
Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Abdominoplasty
Description: Abdominoplasty
Study NCT04284410 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: CLASP-PE arm
Description: Participants will complete 8-16 weekly or twice weekly individual therapy sessions (with total session number determined by clinical need, as is typical in clinical trials of PE for PTSD), 1 therapy session (session 3) with a supportive significant other (SO), consistent with the CLASP protocol, and 11 brief (30 minute) phone calls as possible, with calls occurring every week in between therapy sessions and on a less frequent basis following treatment termination up to 3 months after the final in-person therapy session. In addition, the supportive SOs will complete 11 brief (30 minute) phone calls with the therapist at the same frequency as participants. Participants will sign a release of information prior to involving the supportive significant other in treatment.
Study NCT04849143 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Stingless bee honey ( Kelulut honey)
Description: The honey will be acquired from Brainey Sdn Bhd, a company that provides stingless bee honey certified with Good Manufacturing Practice (GMP), ISO 22000, and Halal.~As the honey used is not medical-grade honey, sterilization with 25kGy gamma-ray irradiation will be done for safety purposes to eradicate any potential life-threatening infection such as spores from Clostridium botulinum.
Study NCT04849143 — intervention group
Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Gel dressing
Description: Smith-Nephew's Intrasite gel
Study NCT04710992 — intervention group
Intervention type: PROCEDURE
Group type: SHAM_COMPARATOR
Intervention: Isolated needling procedure
Description: The needle will be inserted into the common extensor tendon of the epicondyle (dominant elbow) for 90 seconds without galvanic current.
Study NCT04710992 — intervention group
Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Low intensity percutaneous electrolysis
Description: Once the needle is located in the common extensor tendon of the epicondyle (dominant elbow), a single impact of galvanic current will be applied with an intensity of 0.3 mA for 90 seconds.
Study NCT04710992 — intervention group
Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: High intensity percutaneous electrolysis
Description: The needle will be inserted in the target position during the same time as in the other groups (90 seconds). During the first stage of intervention the needle will be imbedded without galvanic current and when the end of the application time approaches (approximately 75 seconds) three impacts of galvanic current will be applied with an intensity of 3 mA and a duration of 3 seconds each.
Study NCT06286267 — intervention group
Intervention type: DIAGNOSTIC_TEST
Intervention: imaging
Description: Patient medical imaging materials including ultrasound, mammography, CT, MRI
Study NCT05545878 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Super enhanced single vision lens 01 for spectacles
Description: This is a spectacle lens designed to have a small amount of positive power towards the bottom of the lens as this is the area that is in line with the eye when downwards for near tasks such as looking at a digital device.
Study NCT05378048 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: PDO-guided treatment
Description: A biopsy of the tumour will be performed for PDO culture and Genome-guided drug screening.~An Multidisciplanary Tumour Board will review the drug screen results and recommend the use of a drug with a response in a PDO.
Study NCT05378048 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: standard of care
Description: the standard of care will include all treatments that have been reported to improve survival or quality of life in randomized trials.
Study NCT06257134 — intervention group
Intervention type: OTHER
Group type: OTHER
Intervention: No systematic monitoring of symptoms
Description: No systematic monitoring of symptoms will be carried out, and patients will receive the usual care. Data collection will be carried out with the assistance of a clinical research nurse up to 12 months, then under the direction of local healthcare teams at 18 months.
Study NCT06257134 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Systematic monitoring of symptoms
Description: once a month, individual patient scores will be sent to dialysis staff. Any score of 3 (severe symptoms) or 4 (overwhelming) on a scale of 0 to 4, on the IPOS-Renal instrument, will be permanently reported to the referrer to trigger the patient's usual symptom management.~Patients will complete 3 further HRQoL questionnaires at baseline, M6, M12 and M18: EQ-5D-5L, KDQoL-36, SONG Fatigue.~A clinical research nurse will be present in half of the participating dialysis units to help patients and dialysis teams to include and follow up patients, up to 12 months. Between 12 and 18 months, data will be collected in real life, under the guidance of local healthcare teams.~In the other half of the dialysis units, data will be collected under the direction of the local healthcare teams, who will have to organize themselves to ensure data collection. These units will also be asked to conduct semi-structured interviews as part of the qualitative phase.
Study NCT06391476 — intervention group
Intervention type: OTHER
Intervention: Study of the evolution of a cohort of children born between 22 and 25 weeks gestational age
Description: * Study of mortality in a cohort of children born between 22 and 25 weeks gestational age~* Study of neonatal morbidity~* Description of postnatal growth~* Description of nutrition and breastfeeding at discharge~* Study of the neurological, respiratory and growth outcome at 2 years.
Study NCT05328414 — intervention group
Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Prednisolone
Description: intranasal fast dissolving film to be applied intranasal. it contains 0.005 mg Presdnisolone
Study NCT05328414 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Prednisolone
Description: intranasal fast dissolving film to be applied intranasal. it contains 0.005 mg Presdnisolone
Study NCT05263726 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: DSMP through a Mobile Applications
Description: This interventional divided the disease self-management program manual for patients with hypertension into 4 units, including: Unit 1: hypertension brief introduction and complications. Unit 2: dietary precautions for patients with hypertension. Unit 3: medication treatments for patients with hypertension. Unit 4: the content included stress management (emotional control, spiritual support) of patients with hypertension. The experimental group received the mobile apps educational program for at least 30 minutes each session and at least once every two days. After two weeks and six weeks, a follow-up telephone interview helped to strengthen the health self-management self-confidence. The researcher used the back office administration at the computer end to observe how the experimental group operated and used the mobile devices. The effect of interventions was then evaluated after three months when the patients returned.
Study NCT04569760 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: 50:2 mg(CBD:THC)/ml - Cannabinoid Oil Oral Preparation- titrated as tolerated up to a maximum 8mls twice daily (200 mg- 800 mg total dose)
Description: Oral cannabinoid oil preparation dosed in 1ml increments
Study NCT04569760 — intervention group
Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo Oil
Description: Oral MCT Oil Preparation - No cannabinoids- titrated as tolerated up to a maximum of 8mls twice daily (equivalent to 200 mg- 800 mg total dose of the active product)
Study NCT05254600 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: RISE for Nurse Leaders Program
Description: Psychoeducational sessions designed to impact resilience, insight, self-compassion, and empowerment
Study NCT05254600 — intervention group
Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: RISE for Nurse Leaders Program
Description: Psychoeducational sessions designed to impact resilience, insight, self-compassion, and empowerment
Study NCT05126134 — intervention group
Intervention type: DIAGNOSTIC_TEST
Intervention: KSADS (Kiddie Schedule for Affective Disorders and Schizophrenia)
Description: completion of the semi-structured questionnaire: the KSADS (Kiddie Schedule for Affective Disorders and Schizophrenia). The duration is 1h30 to 2h
Study NCT05154357 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Elastic Sac
Description: Half an hour before the feeding time, the infant will be placed in the elastic sac, be laid in the right lateral position within the nest with an angle of 45 degrees and will be allowed to take a rest within the elastic sac for half an hour. At the feeding time, he/she will be fed by the researcher with a bottle in the right lateral position within the elastic sac with an angle of 45 degrees without making any change in his/her position.
Study NCT05154357 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Control
Description: Half an hour before the feeding time, the infant will be laid in the right lateral position within the nest with an angle of 45 degrees without performing any different application and will be allowed to take a rest. At the feeding time, he/she will be fed by the researcher with a bottle in the right lateral position within the elastic sac with an angle of 45 degrees without making any change in his/her position.
Study NCT06506214 — intervention group
Intervention type: OTHER
Intervention: Questionnaires
Description: Responses to questionnaires:~* Cutaneous Lupus Erythematosus Disease Area and Severity Index (CLASI)~* Medical Adherence Self-Report Inventory (MASRI)~* Morisky Medication Adherence Scale (MMAS4)~* Visual analog scale (VAS) on the perception of disease control~* Belief on Medicine Questionnaire (BMQ)~* Care patient Feedback measure~* Hospital Anxiety and Depression Scale (HAD)~* Dermatology Life Quality Index (DLQI)
Study NCT04642378 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: iNCDSS based insulin regime
Description: Patients of this group will receive the insulin regime set by the AI assisted insulin titration system (iNCDSS).
Study NCT04642378 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: routine insulin treatment regime
Description: Patients of this group will receive the insulin regime recommended by professional endocrinologists.
Study NCT06318260 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Dobutrex
Description: Dobutamine (Dobutrex®) infusion. will be performed with a stepwise dobutamine dosage increase every 5 minutes (2,3,5,10,20 ug/kg/min). Dobutamine dosage will only be increased to 40 ug/kg/min in participants with ongoing beta-blocker treatment to ensure an appropriate dobutamine response. As dobutamine and its metabolites are excreted renally, the dose will be reduced to max 10 ug/kg/min in participants with eGFR below 30 mL/min/1,73 m2. Echocardiography, blood pressure, heart rate, and invasive pressure and flow measurements will be obtained before the infusion starts, at each infusion stage, and during the recovery period after the infusion is stopped.
Study NCT05076331 — intervention group
Intervention type: DIAGNOSTIC_TEST
Intervention: PI-2620 tracer for Tau PET scan
Description: Tau PET scans are obtained using PI-2620 tracer provided by Life Medical Imaging.
Study NCT04952493 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Anlotinib hydrochloride
Description: Anlotinib hydrochloride may stop the growth of tumor cells and improve iodine uptake.
Study NCT04952493 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Sodium Iodide I 131
Description: RAI treatment may shrink the tumor
Study NCT04952493 — intervention group
Intervention type: DRUG
Group type: OTHER
Intervention: Sodium Iodide I 131
Description: RAI treatment may shrink the tumor
Study NCT04952493 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Penpulimab
Description: Penpulimab is a novel structure Immune checkpoint inhibitor. The combination of Penpulimab and RAI might have synergistic effects for DTC.
Study NCT04717609 — intervention group
Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Saphenous Nerve Block
Description: Preoperative Saphenous Nerve Block for partial Meniscectomy
Study NCT04717609 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Ropivacaine injection
Description: preoperatively the participant will receive an injection ar the surgical site of 5 milliliters (mL) of 0.5% ropivacaine
Study NCT05735236 — intervention group
Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: BFR Cuff
Description: The BFR cuff will be applied to the proximal thigh of the surgical leg while the patient completes specified physical therapy exercises.80% occlusion pressure will be determined by PT's in clinic through the use of a Delphi unit. Subjects will then be able to use the Saga Fitness app to adjust this pressure if it differs from the automatic calibrated pressure.