AIM-Harvard/TrialPanorama-filtered huggingface dataset:
Study NCT06373549 — intervention group
Intervention type: PROCEDURE
Intervention: Patients with coronary artery bypass surgery routine procedural administration of cardioplegia solutions
Description: To investigate the effectiveness of myocardial protection methods, blood samples were collected from the coronary sinus before the aortic cross-clamping and at 4 minutes after aortic cross-clamping, through a coronary sinus cannula with a yellow-capped gel tube. The collected blood samples were kept in an upright position for 20 minutes to allow separation into serum fraction, then centrifuged at 3000 g for 10 minutes (Beckman Coulter, Microfuge 16, USA). The obtained serums were aliquoted into 250 μl portions in Eppendorf tubes, separately for each patient.
Study NCT06373549 — intervention group
Intervention type: PROCEDURE
Intervention: Patients who underwent heart valve surgery without coronary artery disease routine procedural administration of cardioplegia solutions
Description: To investigate the effectiveness of myocardial protection methods, blood samples were collected from the coronary sinus before the aortic cross-clamping and at 4 minutes after aortic cross-clamping, through a coronary sinus cannula with a yellow-capped gel tube. The collected blood samples were kept in an upright position for 20 minutes to allow separation into serum fraction, then centrifuged at 3000 g for 10 minutes (Beckman Coulter, Microfuge 16, USA). The obtained serums were aliquoted into 250 μl portions in Eppendorf tubes, separately for each patient.
Study NCT04706923 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: BCV
Description: Brincidofovir (BCV) is a lipid conjugate of the antiviral cidofovir that enables optimal intracellular levels of the active drug.
Study NCT06454942 — intervention group
Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Nutrient-fortified egg
Description: Consumption of nutrient-fortified eggs with habitual diet
Study NCT06454942 — intervention group
Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Regular egg with habitual diet
Description: Consumption of regular egg with habitual diet
Study NCT06402071 — intervention group
Intervention type: DIAGNOSTIC_TEST
Intervention: Ascitic fluid study
Description: Ascitic fluid study will be obtained from all participants
Study NCT05670782 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: KM-819
Description: Participants will receive oral doses of KM-819 once-daily
Study NCT06197971 — intervention group
Intervention type: OTHER
Group type: OTHER
Intervention: Instrument Assisted Soft Tissue Mobilization
Description: Graston Technique instruments to apply strokes and movements along the length of the muscle fibers. Sweeping strokes, cross-fiber friction, and circular motions patterns will be applied on hamstring muscles.
Study NCT06197971 — intervention group
Intervention type: OTHER
Group type: OTHER
Intervention: Therapeutic Cupping Technique
Description: Stationary cupping technique will be used for a duration of 5-15 minutes with multiple Silicone Cups applied on the Hamstrings.
Study NCT05478369 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: storybook
Description: anxiety and fear during operative
Study NCT05670782 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo
Description: Participants will receive matching placebo once-daily
Study NCT04572282 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Mentora app
Description: Remote monitoring mobile app
Study NCT04562311 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Chidamide
Description: Chidamide: 30mg orally BIW. Immunotherapy: tislelizumab,the fixed dose of 200 mg IV. Treatment cycles are repeated every 3 weeks.
Study NCT05943262 — intervention group
Intervention type: DEVICE
Intervention: mesoscale nonlinear optical microscope
Description: The mesoscale nonlinear optical microscope based on the principles of nonlinear optics and computed-algorithms can acquire large-area image within few minutes.
Study NCT05000216 — intervention group
Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Moderna mRNA-1273
Description: Administration: One dose administered intramuscularly.
Study NCT05954702 — intervention group
Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Supercharged TRAM esophagectomy
Description: Esophagectomy, immediately followed by supercharged esophagogastroplasty. Use the transverse rectus abdominis myocutaneous (TRAM) flap transfers to surgically create a new anastomosis in the left gastroepiploic vessels.
Study NCT05000216 — intervention group
Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: BNT162b2
Description: Administration: One dose administered intramuscularly.
Study NCT05954702 — intervention group
Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Conventional Esophagectomy
Description: Esophagectomy, immediately followed by an esophagus reconstruction trough esophagogastroplasty.
Study NCT05092646 — intervention group
Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Axolotl Ambient
Description: Axolotl Ambient is an allogeneic amniotic intra-articular injection therapy consisting of a growth factor and cytokine-rich fluid derived from human amnion cells.
Study NCT05092646 — intervention group
Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Drug/Placebo: 0.9% Normal Saline
Description: Drug/Placebo: 0.9% Normal Saline
Study NCT06150625 — intervention group
Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Orthopedic Manaual Therapy
Description: Can include either spinal mobilizations or spinal manipulation therapy targeting the stiff or symptomatic level of the lumbar spine. Various types of mobilization or manipulation may be used based on the therapists clinical reasoning. The therapist will determine which technique and dosage parameters for each subject based on individual patient clinical data. Common mobilizations techniques involve gently and repeatedly applying pressure over different parts of the patient's spine that is associated with their symptoms. For a manipulation, the patient will be positioned in side-lying position. The therapist will then position the patient further to target the symptomatic level. The patient is asked to take a deep breathe in and out. The therapist will slowly add pressure through the trunk and apply a fast but small thrust motion toward the table.
Study NCT06150625 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Orthopedic Manaual Therapy
Description: Can include either spinal mobilizations or spinal manipulation therapy targeting the stiff or symptomatic level of the lumbar spine. Various types of mobilization or manipulation may be used based on the therapists clinical reasoning. The therapist will determine which technique and dosage parameters for each subject based on individual patient clinical data. Common mobilizations techniques involve gently and repeatedly applying pressure over different parts of the patient's spine that is associated with their symptoms. For a manipulation, the patient will be positioned in side-lying position. The therapist will then position the patient further to target the symptomatic level. The patient is asked to take a deep breathe in and out. The therapist will slowly add pressure through the trunk and apply a fast but small thrust motion toward the table.
Study NCT06150625 — intervention group
Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Dry Needling
Description: dry needling both sides of the symptomatic level(s) of the lumbar spine as well as needling other areas in the lower extremity and pelvis based on the results of their clinical evaluation and/or the subjects presenting symptoms. Dry needling involves the insertion of a monofilament needle (nothing is injected) into symptomatic soft tissue. The therapist will determine which technique and dosage parameters for each subject based on individual patient clinical data.
Study NCT06150625 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Dry Needling
Description: dry needling both sides of the symptomatic level(s) of the lumbar spine as well as needling other areas in the lower extremity and pelvis based on the results of their clinical evaluation and/or the subjects presenting symptoms. Dry needling involves the insertion of a monofilament needle (nothing is injected) into symptomatic soft tissue. The therapist will determine which technique and dosage parameters for each subject based on individual patient clinical data.
Study NCT06150625 — intervention group
Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Home exercise program
Description: 5 exercises will be selected from 10 options intended to reinforce the improvements made from treatment.
Study NCT06150625 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Home exercise program
Description: 5 exercises will be selected from 10 options intended to reinforce the improvements made from treatment.
Study NCT06150625 — intervention group
Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Patient education
Description: Patient education on the low back condition, advice to stay active, and home exercise performance.
Study NCT06150625 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Patient education
Description: Patient education on the low back condition, advice to stay active, and home exercise performance.
Study NCT05111925 — intervention group
Intervention type: OTHER
Intervention: PREPARE Initial Clinical Assessment - Pilot (two iterations)
Description: Participants will complete a comprehensive set of clinical assessments that includes semi-automated field-expedient functional movement quality, joint ranges of motion, and psychosocial assessments. Participants will also report the most recent scores received on the appropriate service-specific physical fitness assessment.~Functional movement quality assessments:~* Two-Minute Walk~* Gait~* Double Leg Squat~* Single Leg Squat~* Jump-Landing~* Single Leg Triple Hop~* Closed Kinetic Chain Upper Extremity Stability Test~* Functional Movement Screen Shoulder Clearing Test~* Prone Plank~* Active Hip Abduction~Joint range of motion assessments:~* Knee Extension~* Hip Abduction~* Hip Internal Rotation~* Hip External Rotation~* Ankle Dorsiflexion~Psychosocial assessments:~* NIH PROMIS Physical Function, Pain Interference, Depression, \& Anxiety~* Tampa Scale of Kinesiophobia
Study NCT05111925 — intervention group
Intervention type: OTHER
Intervention: PREPARE Initial Clinical Assessment - Pre-Injury (one iteration)
Description: Participants will complete a comprehensive set of clinical assessments that includes semi-automated field-expedient functional movement quality, joint ranges of motion, and psychosocial assessments. Participants will also report the most recent scores received on the appropriate service-specific physical fitness assessment.~Functional movement quality assessments:~* Two-Minute Walk~* Gait~* Double Leg Squat~* Single Leg Squat~* Jump-Landing~* Single Leg Triple Hop~* Closed Kinetic Chain Upper Extremity Stability Test~* Functional Movement Screening Shoulder Clearing Test~* Prone Plank~* Active Hip Abduction~Joint range of motion assessments:~* Knee Extension~* Hip Abduction~* Hip Internal Rotation~* Hip External Rotation~* Ankle Dorsiflexion~Psychosocial assessments:~* NIH PROMIS Physical Function, Pain Interference, Depression, \& Anxiety~* Tampa Scale of Kinesiophobia
Study NCT05111925 — intervention group
Intervention type: OTHER
Intervention: PREPARE Initial Clinical Assessment - Post-Injury (up to three iterations)
Description: Participants will complete a comprehensive set of clinical assessments that includes semi-automated field-expedient functional movement quality, joint ranges of motion, and psychosocial assessments. Participants will also report thee most recent scores received on the appropriate service-specific physical fitness assessment.~Functional movement quality assessments:~* Two-Minute Walk~* Gait~* Double Leg Squat~* Single Leg Squat~* Jump-Landing~* Single Leg Triple Hop~* Closed Kinetic Chain Upper Extremity Stability Test~* Functional Movement Screening Shoulder Clearing Test~* Prone Plank~* Active Hip Abduction~Joint range of motion assessments:~* Knee Extension~* Hip Abduction~* Hip Internal Rotation~* Hip External Rotation~* Ankle Dorsiflexion~Psychosocial assessments:~* NIH PROMIS Physical Function, Pain Interference, Depression, \& Anxiety~* Tampa Scale of Kinesiophobia
Study NCT05111925 — intervention group
Intervention type: OTHER
Intervention: PREPARE Optimized Clinical Assessment
Description: Participants will complete an optimized set of clinical assessments that may include semi-automated field-expedient functional movement quality, joint ranges of motion, and/or psychosocial assessments. Participants will also report the most recent scores received on the appropriate service-specific physical fitness assessment.~Functional movement quality assessments:~* Two-Minute Walk~* Gait~* Double Leg Squat~* Single Leg Squat~* Jump-Landing~* Single Leg Triple Hop~* Closed Kinetic Chain Upper Extremity Stability Test~* Functional Movement Screening Shoulder Clearing Test~* Prone Plank~* Active Hip Abduction~Joint range of motion assessments:~* Knee Extension~* Hip Abduction~* Hip Internal Rotation~* Hip External Rotation~* Ankle Dorsiflexion~Psychosocial assessments:~* NIH PROMIS Physical Function, Pain Interference, Depression, \& Anxiety~* Tampa Scale of Kinesiophobia
Study NCT06177314 — intervention group
Intervention type: OTHER
Intervention: correlate the molecular signatures of active lesions of contact dermatitis with allergological results
Description: Data will be collected retrospectively and prospectively from patients' medical records, and will include: clinical information (history, treatments, lifestyle, exposures, lesion location and appearance), patch-test results, histological analysis results, molecular analysis results.
Study NCT04978064 — intervention group
Intervention type: BEHAVIORAL
Group type: OTHER
Intervention: e-health psychological counselling
Description: Intervention group: Women positive for IPV who accept the e-Health intervention and who have been randomly allocated in the intervention group will receive the e-health package as the rest of the cohort, as well as the baseline and outcome measurements. The e-health package will include six video counselling sessions by trained providers and the access to a mobile application for designing security plans, an adapted version of the mobile application My Plan. The content of the six individually tailored sessions will be based on the Dutton's Empowerment Model and the Psychosocial Readiness Model.~Control group: women positive in IPV who accept the e-Health intervention package will be asked for a second consent to receive a delayed intervention (8 weeks later) and to complete as the baseline and outcome measurements. Women can request to leave the control group at any time and to receive the intervention immediately (in which case they data will be part of the cohort study).
Study NCT04978064 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: e-health psychological counselling
Description: Intervention group: Women positive for IPV who accept the e-Health intervention and who have been randomly allocated in the intervention group will receive the e-health package as the rest of the cohort, as well as the baseline and outcome measurements. The e-health package will include six video counselling sessions by trained providers and the access to a mobile application for designing security plans, an adapted version of the mobile application My Plan. The content of the six individually tailored sessions will be based on the Dutton's Empowerment Model and the Psychosocial Readiness Model.~Control group: women positive in IPV who accept the e-Health intervention package will be asked for a second consent to receive a delayed intervention (8 weeks later) and to complete as the baseline and outcome measurements. Women can request to leave the control group at any time and to receive the intervention immediately (in which case they data will be part of the cohort study).
Study NCT05000216 — intervention group
Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Ad26.COV2.S
Description: Administration: One dose administered intramuscularly.
Study NCT05738694 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Axitinib plus Toripalimab
Description: Preoperative treatment with axitinib will be given for 3 months, 5 mg twice daily, orally. Preoperative treatment with Toripalimab will be given for 4 cycles (3 weeks considered one cycle), 240 mg, Q3W.
Study NCT05738694 — intervention group
Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: nephrectomy
Description: nephrectomy
Study NCT05738694 — intervention group
Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: nephrectomy
Description: nephrectomy
Study NCT05000216 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Continue IS (MMF or MPA)
Description: Participants continue to take their immunosuppressive (IS) medications for management of their autoimmune disease without alterations in schedule and dosing.
Study NCT05720455 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Fexofenadine HCL and pseudoephedrine HCL
Description: Extended-Release Tablets
Study NCT04562116 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Nemolizumab
Description: Nemolizumab 30 mg will be administered as SC injections.
Study NCT04562116 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: CYP 450 Substrates
Description: CYP substrates (Caffeine, Warfarin Sodium, Midazolam, Omeprazole, and Metoprolol Tartrate) will administered orally at Week 0 (Day 1) and Week 10 as per the commercially available prescribing information.
Study NCT05000216 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Continue IS (MTX)
Description: Participants continue to take their immunosuppressive (IS) medications for management of their autoimmune disease without alterations in schedule and dosing.
Study NCT05000216 — intervention group
Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Continue IS (B cell depletion therapy)
Description: Participants will continue to take their prescribed immunosuppressive (IS) medications without alterations in schedule and dosing.
Study NCT05000216 — intervention group
Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Monovalent [B.1.351] CoV2 preS dTM-AS03
Description: One dose administered intramuscularly
Study NCT05000216 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Withhold IS (MMF or MPA)
Description: Participants withhold their cohort-defining immunosuppressive (IS) medications for management of their autoimmune disease before and after the additional vaccine dose per protocol instructions.
Study NCT04376528 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Cyclosporin A
Description: Ursodeoxycholic acid combination of immunosuppressive agents(methylprednisolone with cyclosporin A)
Study NCT04376528 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Mycophenolate Mofetil
Description: Ursodeoxycholic acid combination of immunosuppressive agents(methylprednisolone with mycophenolate mofetil )
Study NCT06310928 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Thermal Blanket
Description: Thermal blankets, a passive heating blanket, have a silver surface to prevent heat loss through radiation. Thermal insulation is achieved thanks to the fact that they are covered with a reflective surface to reflect light radiation, i.e. thermal radiation. It is a cost-effective, easy-to-clean, flexible material that takes the desired shape. Thermal blankets generate heat by providing thermal insulation with infrared radiation and can provide thermal vasodilation or thermotherapy. In 2013, Lima et al. used infrared thermal blankets to provide thermal vasodilation and as a result, it was found to reduce vascular resistance. Therefore, FORCLAZ brand blanket, also known as emergency blanket, used in natural disaster management, peripheral vascular resistance studies and hypothermia prevention studies was used in this study.
Study NCT05609916 — intervention group
Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Cognitive Behavioral Therapy
Description: During Phase I, participants will receive open label (no blinding) CBT during their study participation for 12 to 18 weeks.~During Phase II, participants will continue receiving CBT maintenance sessions every two weeks for the first 4 weeks, followed by sessions every four weeks. They will also meet with the study physician every 2 weeks via telepsychiatry appointments for clinical and scalar assessment.
Study NCT06284031 — intervention group
Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: 3 fractions HDR brachytherapy
Description: The 3 fractions of HDR brachytherapy may be delivered in the following ways:~Option 1: 3 insertions over 2 non-consecutive days:~Option 2: 3 insertions over 3 non-consecutive days
Study NCT05000216 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Withhold IS (MTX)
Description: Participants withhold their cohort-defining immunosuppressive (IS) medications for management of their autoimmune disease before and after the additional vaccine dose per protocol instructions.
Study NCT05000216 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Withhold IS (B cell depletion therapy)
Description: Participants who are taking MMF, MPA, or MTX in addition to BCDTs will withhold these medications (MMF, MPA, or MTX ) before and after the additional vaccine dose per protocol instructions. Participants will continue to take their prescribed BCDTs without alterations in schedule and dosing.
Study NCT05609916 — intervention group
Intervention type: BEHAVIORAL
Group type: PLACEBO_COMPARATOR
Intervention: Cognitive Behavioral Therapy
Description: During Phase I, participants will receive open label (no blinding) CBT during their study participation for 12 to 18 weeks.~During Phase II, participants will continue receiving CBT maintenance sessions every two weeks for the first 4 weeks, followed by sessions every four weeks. They will also meet with the study physician every 2 weeks via telepsychiatry appointments for clinical and scalar assessment.
Study NCT05000216 — intervention group
Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Moderna mRNA-1273, Bivalent
Description: Administration: One dose administered intramuscularly.
Study NCT05136378 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Low Dose Selenious Yeast Tablets
Description: Low dose of Selenious Yeast Tablets
Study NCT05136378 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: High Dose Selenious Yeast Tablets
Description: High Dose Selenious Yeast Tablets
Study NCT05000216 — intervention group
Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: BNT162b2, Bivalent
Description: Administration: One dose administered intramuscularly.