AIM-Harvard/TrialPanorama-filtered huggingface dataset:
Study NCT04757584 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Beta blockers
Description: The intervention is a two-arm crossover withdrawal/ reversal design (On \[A\] vs Off \[B\]) with up to 4 periods, each period lasting up to 6 weeks. During the On period (A), subjects will be on their beta blocker. During the Off period (B), their beta blockers will be down-titrated and subsequently discontinued.~Subjects will be randomized into either ABAB or BABA sequences.
Study NCT06088628 — intervention group
Intervention type: DIAGNOSTIC_TEST
Intervention: Facial expression; Electroencephalogram; MRI
Description: Recording facial expressions of participants, EEG recordings, and MRI scans.
Study NCT05170737 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo
Description: PART I: A total of 32 healthy male and female subjects will be randomized into four consecutive single ascending dose cohorts of 8 subjects. The study will have 4 different doses of AEF0217 (0.2, 0.6, 2 \& 6 mg) and 1 dose of matching placebo. A given subject can be randomized only in one dose level cohort.~PART II: A total of 24 healthy subjects will be randomized in three consecutive multiple ascending dose cohorts of 8 subjects. The study will have 3 different doses of AEF0217 (0.6, 2 \& 6 mg) and 1 dose of matching placebo. Doses could be modified following the results of FIH-SAD. A given subject can be randomized only in one dose level cohort.
Study NCT05999253 — intervention group
Intervention type: PROCEDURE
Intervention: Modified thoracolumbar plane block (mTLIP)
Description: Modified thoracolumbar plane block (mTLIP): under ultrasound-guided, the lateral compartment of the longissimus muscle and iliocostal muscle muscles are imagined and the block needle is placed in the interfascial plane of these two muscles and local anesthesic solution is appliced.~* 20 ml of 0.25% bupivacaine will be used on each side (total of 40 ml of 0.25% bupivacaine will be used)~* to be administered only approximately 20-30 minutes before the onset of anaesthesia.
Study NCT05999253 — intervention group
Intervention type: PROCEDURE
Intervention: Erector spinae plane block (ESP)
Description: Erector spinae plane block (ESP): After determining the vertebral spinal process and trapezius, rhomboid major and erector spinae muscles with ultrasound guidance, the block needle is advanced in the cranio-caudal direction with an in plane approach and local anaesthetic solution is applied to the plane between the erector spinae muscle and the transverse process when the needle rests on the transverse process.~* 20 ml of 0.25% bupivacaine will be used on each side (total of 40 ml of 0.25% bupivacaine will be used)~* to be administered only approximately 20-30 minutes before the onset of anaesthesia
Study NCT06223191 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Brief Negotiated Interview
Description: The BNI is a specialized brief intervention for the medical setting, has foundations in motivational interviewing techniques. The BNI helps health care providers explore health behavior change with patients in a respectful, non-judgmental way within a finite time period. The BNI is in the form of an algorithm, or script, that guides providers through the health intervention with carefully phrased key questions and responses, all at the providers' fingertips
Study NCT06223191 — intervention group
Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Narrative Interview
Description: The Narrative Interview is a therapeutic approach that aims to motivate the individual's conscious and transformative knowledge, skills, and capabilities. This interview is based on the technical components of narrative therapy, where the patient narrates their story, using externalizing language and considering social and political aspects related to the issue. It will focus on exploring past and present feelings, thoughts, and actions.
Study NCT04694963 — intervention group
Intervention type: PROCEDURE
Intervention: Blood sample
Description: 2 ml venous blood was collected and separated into serum.
Study NCT04694963 — intervention group
Intervention type: PROCEDURE
Intervention: Data collection
Description: 1. Whether the patient has been vaccinated with DPT vaccine and record the time of vaccination;~2. Medication situation of patients in the past year, including rescue drugs, antitussive and expectorant drugs, inhaled corticosteroids and antibiotics;
Study NCT04694963 — intervention group
Intervention type: PROCEDURE
Intervention: Throat swab
Description: Before the collection of oropharyngeal swabs, instruct the patient to wash the mouth or gargle, fix the patient's head, open the mouth and expose the throat. If necessary, use a tongue depressor to gently press the tongue.~Use the swab to wipe the secretion on both sides of the palatal arch, pharynx and tonsil with a sensitive and gentle action, and quickly withdraw the swab to avoid contacting other parts of the mouth.~Put the swab in the sterile test tube, plug the opening with cotton ball, and send it for inspection and registration in time.
Study NCT05362019 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Compound Norethisterone Enanthate Injection
Description: Combined injectable contraceptive use
Study NCT04974684 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: HeartMate 3
Description: Patients implanted with HeartMate 3 will be randomized in 2:1 ratio in interventional and control group. Patients in interventional group will be switched to therapy with apixaban instead of warfarin.
Study NCT04974684 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Apixaban
Description: Patients implanted with HeartMate 3 will be randomized in 2:1 ratio in interventional and control group. Patients in interventional group will be switched to therapy with apixaban instead of warfarin.
Study NCT04964440 — intervention group
Intervention type: DEVICE
Intervention: Pure-EP
Description: Advanced Signal Acquisition and Processing
Study NCT05957549 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Speech discrimination
Description: Two different speech sounds are played at the same sound intensity.
Study NCT06402799 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Home-based E-biking
Description: The e-biking intervention consists of 3 sessions per week at the beginning of the study and gradually increases over the training period to 6 sessions per week, with three of these sessions being online and group-supervised. Heart rate will be monitored as well as power in Watt at each session.
Study NCT06092671 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Family-centred perioperative care for anaesthesia
Description: The patient in intervention group and parent will receive the Family-centred perioperative care for anaesthesia, including video education, anaesthesia mask practice, electronic pamphlet, distraction strategies and parental presence. The patient will not receive sedatives before surgery. During the anesthesia induction period, it is recommended that the parent be instructed by the anesthesiologist to complete the induction of inhalation of the anesthesia mask, and the patient will be accompanied by the parent during the awakening period.
Study NCT05362019 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Compound Norethisterone Enanthate Injection
Description: Combined injectable contraceptive use
Study NCT05362019 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: One-to-one Service
Description: A mobile phone based service system will be used to pushing contraceptive knowledges, reminding injection, providing consultation on adverse reactions and ect.
Study NCT05362019 — intervention group
Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Family Planning Service
Description: routine family planning service and contraceptive service.
Study NCT06310668 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: group cognitive behavioral therapy sessions
Description: 12 group CBT sessions based on catching and challenging cognitive errors and behavioral techniques to deal with substance use problems
Study NCT05702619 — intervention group
Intervention type: DRUG
Intervention: Optional non-IMP pimonidazole
Description: patients will be asked to ingest an oral formulation of pimonidazole hydrochloride (HCl) (Oral HypoxyprobeTM-1). Pimonidazole HCl is a marker for hypoxia in tumour tissue when ingested as an encapsulated solid. Following oral administration, pimonidazole distributes throughout the body where it covalently binds to normal and tumour tissues that have regions of low oxygen concentrations (pO2 of ≤ 10 mmHg at 37oC). The tissue binding can be visualised by immunohistochemistry / light microscopy. The capsules are to be taken within 8-16 hours (optimal timepoint 12 hours) before the planned first biopsy within Arm 1 and before radical prostatectomy for patients in Arm 2. If the patient refuses the pimonidazole, forgets to take it, or if it is not available, the patient can still participate in the study and their samples will be stained for hypoxia post-biopsy.
Study NCT05702619 — intervention group
Intervention type: DIAGNOSTIC_TEST
Intervention: CT-guided Bone Biopsy
Description: A CT-guided biopsy of a bone metastasis that is deemed to be easy to biopsy and in an area without major risk for pathological fracture or bleeding will be taken during the biopsy visit. Patients will receive routine local anaesthetic of the region to be biopsied followed by thorough disinfection of the biopsy site with antiseptic wipes. Patients will be asked to fast on the day of the procedure and to have an intravenous cannula inserted to allow the use of medication causing minimal sedation (for example midazolam and/or fentanyl) during the procedure if required to alleviate discomfort or pain.
Study NCT05702619 — intervention group
Intervention type: DIAGNOSTIC_TEST
Intervention: TRUS-guided Targeted Transperineal Prostate Biopsy
Description: Transperineal Prostate Biopsy will be performed following standard clinical practice of local department. This will include pre-operative oral analgesia and prophylactic antibiotic treatment according to local hospital policy for transperineal prostate biopsies.
Study NCT05702619 — intervention group
Intervention type: PROCEDURE
Intervention: Radical Prostatectomy
Description: Radical Prostatectomy will be performed according to standard of care robotic approach and as relayed to the patient by the attending urologic surgeon. The side effects of the surgery are the ones reported in the literature and the latest participant information leaflet provided prior patient consent (e.g. risk of erection disfunction, incontinence, etc.).
Study NCT05702619 — intervention group
Intervention type: DIAGNOSTIC_TEST
Intervention: Whole-body MRI
Description: Whole-body MR imaging (wbMRI) will be performed once, before or after the biopsy study visit, depending on available examination slots in the Department of Radiology. WbMRI images will allow comparison of the numbers of bone metastases detected by routine bone scan and wbMRI for sensitivity assessment of both techniques for oligometastatic disease.
Study NCT05702619 — intervention group
Intervention type: DIAGNOSTIC_TEST
Intervention: Prostate MRI scans
Description: Patients within Arm 2 will be offered the option to undergo additional MR imaging of the pelvis in addition to any standard of care imaging acquired. In patients who agree to undergo additional scans, MRI scans will be performed on 2 occasions prior to the radical prostatectomy. MRI scans will be acquired on either the MR sim diagnostic scanner, on the MR Linac scanner or on both.
Study NCT05702619 — intervention group
Intervention type: OTHER
Intervention: Baseline bloods - for germline testing
Description: Arm 1 -~* 1-2 x 3.5mL blood samples collected into EDTA tubes for germ line DNA extraction and processing to PBMC for banking and future profiling of immune cell populations~* 1 x 10mL serum tubes for future, biobank related research projects, ie lipidomics, metabolics and microRNA analysis~ARM 2 -~A blood sample (maximum 20ml) will be taken for standard of care blood tests prior to prostatectomy including Full Blood Count, Renal Function and PSA. At the same time these standard of care bloods are taken, additional bloods - a maximum of 30ml - will be taken for research purposes as required for the following downstream analysis:~* Germ line DNA extraction and optional processing to PBMC for banking and future profiling of immune cell populations~* Biobank related research projects, ie lipidomics, metabolics and microRNA analysis
Study NCT05702619 — intervention group
Intervention type: OTHER
Intervention: Baseline bloods for CTCs and ct DNA taken at same time as baseline bloods in Arm 1
Description: 2 x 10mL Streck cell-free DNA blood collection tubes® for circulating tumour cell (CTC) collection and circulating tumour DNA (ctDNA) extraction.
Study NCT05702619 — intervention group
Intervention type: OTHER
Intervention: Post-pimonidazole bloods for CTCs and ctDNA
Description: ARM 1 - 2 x 10mL Streck cell-free DNA blood collection tubes® for circulating tumour cell (CTC) collection and circulating tumour DNA (ctDNA) extraction.
Study NCT04764253 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Modified Sodium Watcher Program + Digital Self-Monitoring
Description: Participants randomized to the experimental group will be asked to follow the modified Sodium Watchers Program intervention along with goal setting for low salt foods. Each participant will be registered to assign a unique ID in the Connected Health Platform developed by the Center on Smart and Connected Health Technologies at UT Health Science Center San Antonio and each account from the individuals' wireless and wearable devices (Fitbit and BP monitor) will be connected to his or her unique ID through this platform. Participants will be instructed to log their activities in real-time, including food intake and in-home BP monitoring using Fitbit and accompanied mobile app and BP monitor. Through the Connected Health Platform, the Fitbit app and BP monitor will transmit the data of the intervention group to the research team.
Study NCT04764253 — intervention group
Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Usual care + Digital Self-Monitoring
Description: Participants randomized to the control group will be asked to follow usual care which is based on their routine medical and nursing care for hypertension that consists of a recommendation to follow a sodium-restricted diet and take medications as prescribed. The participants will receive wireless and wearable devices (Fitbit wristband, BP monitor). Each participant will be registered to assign a unique ID in the Connected Health Platform at the baseline and each account from the individual's wireless and wearable devices (Fitbit and BP monitor) will be connected to their unique ID through this platform. Participants will be instructed to log their activities in real-time, including food intake and in-home BP monitoring using Fitbit and accompanied mobile app and BP monitor.
Study NCT06414122 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: mid-frequency whole-body electromyostimulation (WB-EMS)
Description: supervised group training sessions at least once and optionally twice a week, lasting 11-20 minutes, over 12 weeks, 12-24 training sessions in total
Study NCT06414122 — intervention group
Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: conventional exercise training
Description: supervised group training at least once a week, optional additional home-based training once a week, lasting 40 minutes, over 12 weeks, 12-24 training sessions in total
Study NCT06268119 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: training nurses and caring for patients to prevent, diagnose, and intervene in postoperative delirium.
Description: The intervention group received care in line with the postoperative delirium prevention, diagnosis and intervention protocol after the delirium training given by the researcher to intensive care unit nurses.
Study NCT05415384 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Cryoablation of Intercostal Nerves
Description: Using Atricure device, cryoice, intercostal nerves 3-8 will be ablated in the experimental arm. This is in addition to mechanical fixation of rib fractures and multimodal systemic therapy.
Study NCT05415384 — intervention group
Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Standard surgical treatment of patients with multiple rib fractures
Description: Standard surgical treatment of patients with multiple rib fractures
Study NCT06414122 — intervention group
Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: nutritional therapy
Description: conventional nutritional counselling with guidelines and digital nutritional coaching
Study NCT06414122 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: nutritional therapy
Description: conventional nutritional counselling with guidelines and digital nutritional coaching
Study NCT05835258 — intervention group
Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Melatonin with phenyl capsaicin
Description: Blood samples will be collected at different time points following the oral administration of the melatonin supplement with phenyl capsaicin
Study NCT05835258 — intervention group
Intervention type: DIETARY_SUPPLEMENT
Group type: ACTIVE_COMPARATOR
Intervention: Melatonin without phenyl capsaicin
Description: Blood samples will be collected at different time points following the oral administration of the melatonin supplement without phenyl capsaicin
Study NCT06292312 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Craniosacral therapy
Description: Craniosacral therapy is defined as an alternative, massage-like treatment approach using gentle manual force to address somatic dysfunctions of the head and the rest of the body.
Study NCT05763537 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Standard Doula Care Plus PMAD Intervention
Description: Doulas trained in the DONA training, and the PMAD-focused training will provide care to perinatal people.
Study NCT05763537 — intervention group
Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Standard Doula Care
Description: Doulas trained in the DONA training will provide care to perinatal people.
Study NCT05212350 — intervention group
Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Total pancreatectomy
Description: Patients randomized to receive total pancreatectomy at the time of transection of the pancreas will undergo completion total pancreatectomy according to each Institution's operative standards.
Study NCT05212350 — intervention group
Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Pancreatic anastomosis
Description: Patients randomized to receive pancreatic anastomosis at the time of transection of the pancreas will undergo pancreatico-jejunosomy or pancreatico-gastrostomy according to each Institution's operative standards.
Study NCT02651506 — intervention group
Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Electromagnetic Navigation Bronchoscopy
Description: • Participants randomized to the intervention arm will undergo biopsy using the superDimension®InReach™ System. Participants will undergo ENB guided biopsy under general anesthesia or local anesthesia. The procedure will be performed by a thoracic surgeon in the operating room or endoscopy suite. Following electromagnetic mapping, bronchoscopy and biopsy will be performed. Fiducial markings will be placed when necessary.
Study NCT02651506 — intervention group
Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Transthoracic Needle Biopsy
Description: • Patients randomized to the control arm (TTNB) will undergo lung biopsy using standard transthoracic needle biopsy technique. The procedure will be performed under local anesthesia with computed tomography guidance by an interventional radiologist. In this procedure, a CT-image is used to locate the area for biopsy. Once identified, the radiologist applies a local anesthetic and inserts an aspiration needle between the ribs, through normal lung tissue, leading into the biopsy area. The sampled lung tissue is then sent for pathological analysis.
Study NCT06510309 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Venetoclax
Description: B-cell lymphoma inhibitor, tablets taken orally per protocol.
Study NCT06510309 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Rituximab
Description: Anti-CD20 monoclonal antibody, 10mL or 50 mL single-use vials, via intravenous (into the vein) infusion per protocol.
Study NCT06292312 — intervention group
Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Conventional physiotherapy
Description: Range of motion, stretching, resistance exercises. Spasticity inhibition Balance and coordination exercises Walking training Stabilization exercises Breathing exercises
Study NCT06292312 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Conventional physiotherapy
Description: Range of motion, stretching, resistance exercises. Spasticity inhibition Balance and coordination exercises Walking training Stabilization exercises Breathing exercises
Study NCT05296057 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Participants Receiving VR-Exposure Therapy Treatment
Description: In the baseline interview with an exposure therapy specialist and a member of the research team, participants will be presented with approximately three sets of possible exposure scenarios, each associated with approximately three different scenes that increase in severity level. Through discussion with the exposure therapy specialist, the participant will choose the exposure scenario (out of the three options) that most closely resembles their own epilepsy- or seizure-related fears. As the treatment, the participant will be exposed to the scenes that are associated with their chosen exposure set in a hierarchical manner using an immersive head-mounted display. The participant will work through the three levels of the chosen exposure scenario for approximately two weeks, ideally on each level for four days.
Study NCT06252337 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: bioceramic sealer group
Description: epoxy resin based + carrier based technique group. The sealer was inserted in the canal and the carrier was warmed in a dedicated oven (thermaprep) and inserted within 60 seconds.
Study NCT06252337 — intervention group
Intervention type: OTHER
Group type: OTHER
Intervention: bioceramic sealer group
Description: epoxy resin based + carrier based technique group. The sealer was inserted in the canal and the carrier was warmed in a dedicated oven (thermaprep) and inserted within 60 seconds.