AIM-Harvard/TrialPanorama-filtered huggingface dataset:
Study NCT05348239 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Sodium Copper Chlorophyllin
Description: Sodium-copper-chlorophyllin (CHL) is a phytopharmaceutical drug obtained from green plant pigment, chlorophyll. Chlorophyllin scavenges radiation-induced free radicals and reactive oxygen species. It is used as a food colorant and OTC in the USA, Japan, Australia and China for many years for a variety of health benefits including prevention of body odour in geriatric patients, enhanced wound healing, antibacterial action, prevention of cancer in the high-risk populations exposed to hepatocarcinogen aflatoxin B1, treatment of faecal incontinence etc. Studies have shown that CHL has immunostimulatory, anti-inflammatory and antiviral effects in addition to antioxidant and radioprotective properties. It increases the expression of a transcription factor (protein) Nrf2 which improves lymphocyte survival and enables efficient detoxification after exposure to radiation. The duration of therapy will be up to 6 months depending upon the response of participants.
Study NCT05248880 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: AGN-151586
Description: Intramuscular Injection
Study NCT05248880 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo
Description: Intramuscular Injection
Study NCT05942443 — intervention group
Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Pre-treatment
Description: The custom MCP blocking orthosis was made of a 1.6-mm-thick thermoplastic material that extends from the palm over the MCP joint and includes a ring around the proximal phalanx. It is designed to block the MCP joint in flexion of 10°-20° while allowing full range of motion of the proximal and distal interphalangeal joints.
Study NCT05942443 — intervention group
Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Pre-treatment
Description: The custom MCP blocking orthosis was made of a 1.6-mm-thick thermoplastic material that extends from the palm over the MCP joint and includes a ring around the proximal phalanx. It is designed to block the MCP joint in flexion of 10°-20° while allowing full range of motion of the proximal and distal interphalangeal joints.
Study NCT05942443 — intervention group
Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Post-treatment
Description: The RME orthosis was fabricated from 3.2-mm-thick thermoplastic material with the affected finger positioned at an extension of approximately 10°-20° relative to the adjacent fingers.
Study NCT05942443 — intervention group
Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Post-treatment
Description: The RME orthosis was fabricated from 3.2-mm-thick thermoplastic material with the affected finger positioned at an extension of approximately 10°-20° relative to the adjacent fingers.
Study NCT05516511 — intervention group
Intervention type: DIAGNOSTIC_TEST
Intervention: Angiotensin Converting Enzyme test
Description: blood sample is taken SLE patients , healthy control , ACE level will be measured by ELISA kits
Study NCT04971018 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Auricular vagus nerve stimulation
Description: Patients will have 20-minutes stimulation sessions at home twice a day during 3 months.
Study NCT04971018 — intervention group
Intervention type: DEVICE
Group type: PLACEBO_COMPARATOR
Intervention: Sham Auricular vagus nerve stimulation
Description: Patients will have 20-minutes stimulation sessions at home twice a day during 3 months.
Study NCT06113458 — intervention group
Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Standard and One-time Training
Description: Patient-level intervention: Patients in the standard group will receive automated reminder SMS text messages and remote BP monitoring.~Clinic-level intervention: Clinics in the one-time training group will receive one-time training on standard work and algorithms, audit and feedback, and panel-based outreach.
Study NCT06113458 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Standard and Practice Facilitation
Description: Patient-level intervention: Patients in the standard group will receive automated reminder SMS text messages and remote BP monitoring.~Clinic-level intervention: Clinics in the practice facilitation group will receive regular/ongoing training on standard work and algorithms, audit and feedback, and panel-based outreach.
Study NCT06113458 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: High-intensity and One-time Training
Description: Patient-level intervention: Patients in the high-intensity group will receive personalized feedback SMS text messages and remote BP monitoring.~Clinic-level intervention: Clinics in the one-time training group will receive one-time training on standard work and algorithms, audit and feedback, and panel-based outreach.
Study NCT06338722 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Making it Work Systemic Sclerosis
Description: One 2 hour virtual meeting per week for 5 weeks, plus an individual meeting with an occupational therapist and a vocational counselor
Study NCT06113458 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: High-intensity and Practice Facilitation
Description: Patient-level intervention: Patients in the high-intensity group will receive personalized feedback SMS text messages and remote BP monitoring.~Clinic-level intervention: Clinics in the practice facilitation group will receive regular/ongoing training on standard work and algorithms, audit and feedback, and panel-based outreach.
Study NCT06515834 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: FE 999301
Description: To assess the safety and tolerability of FE 999301 after single intravenous (IV) dose infusion in healthy Japanese men
Study NCT06515834 — intervention group
Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Placebo to assess the safety and tolerability of FE 999301 after single intravenous (IV) dose infusion in healthy Japanese men
Study NCT06373640 — intervention group
Intervention type: PROCEDURE
Group type: OTHER
Intervention: Insertion of drains
Description: Insertion of lumbar drain and basal cistern drain
Study NCT06373640 — intervention group
Intervention type: DRUG
Group type: OTHER
Intervention: Vancomycin
Description: Administration of vancomycin
Study NCT05177861 — intervention group
Intervention type: DIAGNOSTIC_TEST
Group type: OTHER
Intervention: EMG
Description: Electromyelography
Study NCT05965752 — intervention group
Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: BrainHQ/Active Comparator Activity
Description: BrainHQ platform provides a set of cognitive activities, like puzzles and games, that are cognitively stimulating and actively engage participants but do not continuously and adaptively challenge them. These activities are designed to be a face-valid, active comparison approach to cognitive therapy, thus participants are blinded, attention time is matched, and overall user experience is identical to the active arms.
Study NCT05965752 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: BrainHQ
Description: BrainHQ is an online cognitive training program, and has been used to improve cognitive function among persons with cognitive impairment based on principles of neuroplasticity.
Study NCT05965752 — intervention group
Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: BrainHQ
Description: BrainHQ is an online cognitive training program, and has been used to improve cognitive function among persons with cognitive impairment based on principles of neuroplasticity.
Study NCT05965752 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: PASC CoRE
Description: PASC CoRE is a manualized, adaptable cognitive rehabilitation intervention adapted from Goal Management Training and other evidence based programs that improve attention and executive functions, among other cognitive domains.
Study NCT05965752 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: tDCS-active
Description: Transcranial direct current stimulation (tDCS) will use a device specifically for home-based use. This device delivers a weak electrical current of 2.0 mA passed through two electrodes placed on the scalp to target the dorsolateral prefrontal cortex region of the brain. The electrodes are single-use for each session and can be attached to a headset by snapping into place.~The device has a user-friendly interface and a large-button keypad, making it is easy to use at home.
Study NCT05725980 — intervention group
Intervention type: DIAGNOSTIC_TEST
Intervention: Cephalometric analysis
Description: Cephalometric analysis will be performed evaluating upper airways landmarks.
Study NCT06126627 — intervention group
Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Stress induction
Description: Induction of anticipatory stress to compare voice and speech control and production with and without exposure to stress.
Study NCT05965752 — intervention group
Intervention type: DEVICE
Group type: PLACEBO_COMPARATOR
Intervention: tDCS-sham
Description: tDCS devices used in the sham arm will be pre-programmed to deliver the same ramp up/down at the beginning/end of the 30-minute period as the active arm, except with no current otherwise delivered during the session.
Study NCT05302986 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Tranexamic acid injection
Description: The dose will be 0.1 mg / kg (= 10 mg/kg) and diluted in a 100 mL infusion bag of sodium chloride. The product will have to be administered as a slow infusion over 10 minutes during the shoulder surgery.
Study NCT05302986 — intervention group
Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Surgery with intravenous injection of Placebo (0.9% sodium chloride). A 100 mL infusion bag of sodium chloride will be administered as a slow infusion over 10 minutes during shoulder surgery.
Study NCT05232331 — intervention group
Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Intake of nitrate rich vegetables
Description: Nutritional intervention for 10 weeks to increase the consumption of vegetables rich in nitrate. At the beginning of the NSPT on visit 1 (week 2), the first of 5 nutritional interventions will begin with the objective of consuming \~ 350 mg of nitrate daily from vegetables
Study NCT06126627 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Stress induction
Description: Induction of anticipatory stress to compare voice and speech control and production with and without exposure to stress.
Study NCT05044702 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Retro walking
Description: Retro walking will be performed on treadmill for 15 min per day for 3 days per week for 4 weeks at self-paced speed.
Study NCT05044702 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: conventional physical therapy
Description: hot pack for 10 mints and conventional exercise program Conventional physiotherapeutic exercise program which consist of exercises such as~* prone leg extension~* prone lying chest elevation~* prone extension with alternate arm and leg lift~* supine bridging, bridging with one leg lift Each exercise will be performed as 2 sets of 12 repetitions of each exercise, each exercise position maintained for 10 s, and a rest of 1 min between the sets will be perform. No external load/resistance will be provided for the exercises, and the participants will be perform the exercise within their available range of motion
Study NCT05044702 — intervention group
Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: conventional physical therapy
Description: hot pack for 10 mints and conventional exercise program Conventional physiotherapeutic exercise program which consist of exercises such as~* prone leg extension~* prone lying chest elevation~* prone extension with alternate arm and leg lift~* supine bridging, bridging with one leg lift Each exercise will be performed as 2 sets of 12 repetitions of each exercise, each exercise position maintained for 10 s, and a rest of 1 min between the sets will be perform. No external load/resistance will be provided for the exercises, and the participants will be perform the exercise within their available range of motion
Study NCT05543798 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Vision-MR Ablation Catheter 2.0
Description: Catheter ablation of ventricular tachycardia
Study NCT04975204 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: TQB3909 Tablets
Description: TQB3909 is an inhibitor targeting BCL-2 protein
Study NCT05299008 — intervention group
Intervention type: DRUG
Intervention: Bethanechol
Description: Infants whom will be treated with bethanechol for tracheobronchomalacia in level IV center Neonatal Intensive Care Unit.
Study NCT04782076 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Dabigatran
Description: Administered orally.
Study NCT04782076 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Selpercatinib
Description: Administered orally.
Study NCT05298917 — intervention group
Intervention type: DEVICE
Group type: OTHER
Intervention: silicone hydrogel contact lens
Description: silicone hydrogel contact lens
Study NCT05215743 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Antioxidant therapy
Description: Active therapy
Study NCT05215743 — intervention group
Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: NaCl 0.9%
Description: Placebo
Study NCT05604482 — intervention group
Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: CXCR4-PET
Description: New imaging modality using CXCR4 for imaging in GCA
Study NCT06510023 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Type of reward presented
Description: Three different types of rewards were presented to both groups during the computerized task: one dollar, one penny, and no reward.
Study NCT06510023 — intervention group
Intervention type: BEHAVIORAL
Group type: OTHER
Intervention: Type of reward presented
Description: Three different types of rewards were presented to both groups during the computerized task: one dollar, one penny, and no reward.
Study NCT04981717 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: REGN1908-1909
Description: Subcutaneous (SC) for a total of 5 administrations
Study NCT06167876 — intervention group
Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: Stereotactic Body Radiotherapy (SBRT) Treatment
Description: The intervention in this study utilizes Stereotactic Body Radiotherapy (SBRT) for treating Hypertrophic Obstructive Cardiomyopathy (HOCM). The process begins with precise localization and planning, employing CT scans, Cardiac MRI (CMR), and echocardiography to accurately identify the target area in the interventricular septum, while avoiding critical structures like the aortic valve, His bundle, and left ventricular papillary muscles. Pre-treatment preparation involves using customized fixation devices to limit patient movement and breathing, coupled with cone-beam CT scans for accurate alignment with the Treatment Planning System (TPS). The treatment itself is delivered using image-guided linear accelerators, administering a single, focused dose of 25 Gy to the targeted area. This approach ensures precise radiation delivery, maximizing treatment efficacy while minimizing risks to surrounding cardiac tissues.
Study NCT06167876 — intervention group
Intervention type: OTHER
Group type: SHAM_COMPARATOR
Intervention: Sham Procedure
Description: The sham procedure in this study is designed to closely mimic the actual Stereotactic Body Radiotherapy (SBRT) process without delivering any radiation. Participants in this arm are subjected to the same initial steps as those in the SBRT group, including precise alignment with the linear accelerator using CT scans and the application of customized fixation devices to limit movement and breathing. However, in this sham intervention, the linear accelerator is activated but does not emit any radiation. The procedure replicates the environmental aspects of the actual treatment, such as the equipment's sounds and lighting, to maintain the study's single-blind nature. This method ensures that participants in the sham group experience a procedure identical in appearance and feel to the SBRT treatment, without receiving any therapeutic dose, thereby serving as an effective control for evaluating the true impact of SBRT in treating HOCM.
Study NCT04951466 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Mindfulness-based therapy for insomnia (MBTI)
Description: Participants randomly assigned to either the MBTI or healthy lifestyle intervention will receive 2 hours weekly session of mindfulness meditation and behavioral sleep strategies for 8 weeks.
Study NCT06241131 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Desflurane Inhalant Product
Description: The Desflurane was inhaled at a starting concentration of 1 MAC, and remifentanil 0.1 μg/kg/min was continuously pumped intravenously.
Study NCT06241131 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Desflurane Inhalant Product
Description: The Desflurane was inhaled at a starting concentration of 1 MAC, and remifentanil 0.1 μg/kg/min was continuously pumped intravenously.
Study NCT04951466 — intervention group
Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Healthy lifestyle intervention
Description: Participants randomly assigned to either the MBTI or healthy lifestyle intervention will receive 2 hours weekly session of mindfulness meditation and behavioral sleep strategies for 8 weeks.
Study NCT04728607 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Compression device.
Description: A compression device is a device that uses circumferential compression to reduce swelling around a stuck ring. The device is used by placing it near, but not overtop, the offending ring, and then is inflated compressing the finger. The device is applied, and the hand elevated, for approximately five minutes. The device is then removed, and with a small amount of lubricant, the ring is removed.
Study NCT04884685 — intervention group
Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: SARS-CoV-2 Inactivated Vaccine
Description: 600SU inactivated virus in 0·5 mL of aluminium hydroxide solution per injection
Study NCT04884685 — intervention group
Intervention type: BIOLOGICAL
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: aluminium hydroxide solution only
Study NCT06496841 — intervention group
Intervention type: DRUG
Intervention: Transnasal Sphenopalatine ganglion block
Description: The transnasal approach to the sphenopalatine ganglion block allows for non-invasive access to the sphenopalatine ganglion, which is located deep in the nasopharynx in a recess posterior to the middle turbinate. A long cotton swab is inserted posterior to the nasopharynx until it is properly seated, and 2 mL of 2% lidocaine is injected through the outer end of the swab and left for 30 minutes. Patients are monitored for any potential complications or adverse effects throughout the procedure and for a period of time afterwards.
Study NCT06496841 — intervention group
Intervention type: DRUG
Intervention: Ultrasound-guided suprazygomatic sphenopalatine ganglion block
Description: The ultrasound transducer is placed in the infrazygomatic area, above the maxilla, at approximately a 45 cephalad angle. With this transducer position, the ptrigopalatine fossa, bounded anteriorly by the maxilla and posteriorly by the pterygoid process, is visualized. A 25 gauge spinal needle is inserted 1 to 1.5 cm above the zygomatic arch and posterior to the posterior orbital rim and advanced through an out-of-plane approach to reach the pterigolapalatine fossa. After the aspiration test, 3 mL of 2% lidocaine is injected and the spread of the drug is monitored by ultrasound. Patients are monitored for possible side effects and complications.
Study NCT04998591 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Fasting
Description: fasting for 7 days (caloric intake \<500 kcal in liquid form)
Study NCT05461131 — intervention group
Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: BPZE1
Description: Live attenuated vaccine
Study NCT05461131 — intervention group
Intervention type: BIOLOGICAL
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Placebo
Study NCT05461131 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Azithromycin
Description: Antibiotic
Study NCT05461131 — intervention group
Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Azithromycin
Description: Antibiotic
Study NCT05461131 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Bordetella Pertussis Challenge Strain
Description: Challenge Strain
Study NCT05461131 — intervention group
Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Bordetella Pertussis Challenge Strain
Description: Challenge Strain
Study NCT04617379 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Stretching
Description: One-year stretching program for 15 minutes every day
Study NCT05346731 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Ondansetron
Description: Ondnsetron will be administered at a dose of 0.15 mg/kg IV/PO every 8 hours on the day(s) of chemotherapy and 3 days after completion of chemotherapy
Study NCT05346731 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Ondansetron
Description: Ondnsetron will be administered at a dose of 0.15 mg/kg IV/PO every 8 hours on the day(s) of chemotherapy and 3 days after completion of chemotherapy
Study NCT05346731 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Dexamethasone
Description: Dexamethasone will be administered at a dose of 5 mg/m2 intravenously/orally once on the day(s) of chemotherapy and 3 days after completion of chemotherapy;
Study NCT05346731 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Dexamethasone
Description: Dexamethasone will be administered at a dose of 5 mg/m2 intravenously/orally once on the day(s) of chemotherapy and 3 days after completion of chemotherapy;
Study NCT05346731 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Aprepitant
Description: Aprepitant will be administered based on body weight:~body weight 30-40 kg: days 1-3 - 80 mg orally; body weight > 40 kg: day 1 - 125 mg orally, days 2, 3 - 80 mg orally
Study NCT05346731 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Aprepitant
Description: Aprepitant will be administered based on body weight:~body weight 30-40 kg: days 1-3 - 80 mg orally; body weight > 40 kg: day 1 - 125 mg orally, days 2, 3 - 80 mg orally
Study NCT05346731 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Olanzapine
Description: Olanzapine will be administered at a dose of 0.07 mg/kg orally on the day(s) of chemotherapy and 3 days after completion of chemotherapy (rounded up to the maximum multiple of 2.5 mg, maximum daily dose of 5 mg).