AIM-Harvard/TrialPanorama-filtered huggingface dataset:
Study NCT06184945 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: RN Implementation Facilitator
Description: ICUs randomized to this arm will receive a RN who will assist with ABCDEF bundle implementation
Study NCT05966961 — intervention group
Intervention type: DEVICE
Intervention: Novosyn® in emergency or elective laparotomy or laparoscopic surgery
Description: Fascia closure (and subcutaneous closure if applicable) after emergency or elective laparotomy or laparoscopic surgery.
Study NCT05966961 — intervention group
Intervention type: DEVICE
Intervention: Polyglactin 910 in emergency or elective laparotomy or laparoscopic surgery
Description: Fascia closure (and subcutaneous closure if applicable) after emergency or elective laparotomy or laparoscopic surgery.
Study NCT04911062 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Bupivacaine HCI without epinephrine
Description: 100 mg administered via injection into the surgical site.
Study NCT04911062 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: HTX-011
Description: HTX-011 (bupivacaine/meloxicam) dose up to 200 mg/6 mg administered via application into the surgical site.
Study NCT04911062 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Luer Lock Applicator
Description: Applicator for instillation.
Study NCT04859894 — intervention group
Intervention type: DIAGNOSTIC_TEST
Intervention: Physiological testing
Description: Cardiopulmonary exercise testing, Lung Function Testing and in some cases echocardiography. 20 subjects will perform DNA-methylation testing.
Study NCT06549413 — intervention group
Intervention type: OTHER
Intervention: Non-Interventional Study
Description: Non-interventional study
Study NCT06620029 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: BMX-001
Description: BMX-001 consists of a porphyrin ring with pyridyl groups attached at each of the four methane bridge carbons. The nitrogen in the pyridyl ring is at the 2 position and has a side chain consisting of six carbons with an ether linkage. A manganese atom is chelated into the porphyrin ring and is the active center of the molecule. This molecule is an enzymatic scavenger of free radical species operating at close to diffusion-limited rates. BMX-001 (7-28 mg) will be given by subcutaneous (s.c.) injection starting on Day 1, Day 8, Day 15, and Day 22 of each 28-day PTX treatment cycle.
Study NCT06620029 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Paclitaxel (Taxol)
Description: Paclitaxel will be given via IV infusion at a dose = 80 mg/m2 on Day 1, Day 8, Day 15, and Day 22 of each 28-day treatment cycle and will be sourced from standard commercial sources. Appropriate pretreatment prior to PTX will be given as per institutional standards. PTX management for any adverse event (AE) in any cycle, reasonably attributed to the chemotherapy agent that requires dose interruption should be managed per package insert, and/or institutional guidelines. Dose modification recommendations are provided in protocol to provide general consistency with dosing. Study Treatment dosing BMX-001 should continue even if the PTX is omitted. The subject may continue on PTX if the AE does not prohibit dosing per institutional practice. Grade 3 or higher infusion PTX reactions or recurrent infusion reactions may require permanent discontinuation of PTX. PTX may be continued in select patients using institutional desensitization protocol.
Study NCT04679012 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Polatuzumab Vedotin
Description: Polatuzumab vedotin will be administered as an IV infusion at 1.8mg/kg on Day 1 of each cycle, every 21 days.
Study NCT04679012 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Rituximab
Description: Rituximab will be obtained from commercial supply, and will be given for a total of 6 cycles for all patients. The drug will be given by IV route.
Study NCT04679012 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Etoposide
Description: Etoposide will be obtained from commercial supply, and will be given for a total of 6 cycles for all patients. The drug will be given by IV route.
Study NCT04679012 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Prednisone
Description: Prednisone will be obtained from commercial supply, and will be given for a total of 6 cycles for all patients. Prednisone will be given orally.
Study NCT04679012 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Cyclophosphamide
Description: Cyclophosphamide will be obtained from commercial supply, and will be given for a total of 6 cycles for all patients. The drug will be given by IV route.
Study NCT04679012 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Hydroxydaunomycin
Description: Hydroxydaunomycin will be obtained from commercial supply, and will be given for a total of 6 cycles for all patients. The drug will be given by IV route.
Study NCT05401448 — intervention group
Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Influenza
Description: Influenza: 0.5 ml of reconstituted Influenza vaccine will be administered intramuscularly in the left upper arm as recommended by the manufacturer.
Study NCT05401448 — intervention group
Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: MMR vaccines
Description: MMR: 0.5 ml of reconstituted MMR vaccine will be administered intramuscularly in the left upper arm as recommended by the manufacturer.
Study NCT05401448 — intervention group
Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Placebo: 0.5 ml of 0.9% NaCl will be administered intradermally in the left upper arm.
Study NCT05112211 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Doxycycline Hyclate
Description: patients administrated with doxycycline tablets 100mg orally per day
Study NCT05106985 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: ApplTree reminder app
Description: The reminder app will be introduced to participants to support adherence to chosen goal-related tasks. Reminder app will be introduced following a baseline phase of 10, 16 or 22 days. The duration of the baseline phase will be randomly assigned using an online random number generator.
Study NCT05341375 — intervention group
Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Thoracic paravertebral block
Description: The patient was placed in lateral supine position, and the T5 spinous process was moved 2 to 3cm laterally to the operative side as the puncture point, and the pleura and T5 transverse process were observed, and the paraspinal space was observed on the lower lateral side of the transverse process. Using in-plane technique, the needle position was adjusted under ultrasound visualization to reach the paraspinal space. 20ml 0.375% ropivacaine was injected into the suction syringe when there was no blood or gas, and the drug liquid could be seen spreading outside the pleura. Landscape sign appeared, indicating successful block
Study NCT05341375 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Esketamine
Description: Group TE received s-ketamine anesthesia induction dose of 0.3 mg/kg on the basis of TA group. Anesthesia maintenance dose of 0.2ug/kg/h was pumped to 30min before the end of the operation
Study NCT05341375 — intervention group
Intervention type: BEHAVIORAL
Group type: OTHER
Intervention: Measurement of cognitive function
Description: Patients undergoing thoracoscopic surgery underwent general anesthesia.MMSE was assessed at one day before surgery, one day after surgery, and three months after surgery
Study NCT05341375 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Measurement of cognitive function
Description: Patients undergoing thoracoscopic surgery underwent general anesthesia.MMSE was assessed at one day before surgery, one day after surgery, and three months after surgery
Study NCT05341375 — intervention group
Intervention type: BEHAVIORAL
Group type: OTHER
Intervention: The assessment of cognitive function
Description: Participants were assessed for MMSE at the same period as the group C
Study NCT05544552 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: TYRA-300
Description: TYRA-300 is an oral, novel potent FGFR 3-selective tyrosine kinase inhibitor that targets tumors that contain activating gene alterations of FGFR3.
Study NCT05724056 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Idroflog®
Description: The study intervention posology will be based on current labeling of Idroflog®. Participants will be self-administering one drop in each eye 4 times a day every day during the study period.~Administration should follow the label guidelines. Participants should detach a single vial from the strip, remove the flap at the top by rotating it and instill 1 drop into the conjunctival sac of each eye, dropping them from above.
Study NCT05724056 — intervention group
Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Sodium Hyaluronate 0.18% (Vismed®)
Description: The control intervention posology will be based on current labeling of Idroflog®. Participants will be self-administering one drop in each eye 4 times a day every day during the study period.~Administration should follow the label guidelines. Participants should detach a single vial from the strip, remove the flap at the top by rotating it and instill 1 drop into the conjunctival sac of each eye, dropping them from above.
Study NCT06186830 — intervention group
Intervention type: OTHER
Intervention: Validity and reliability analyses
Description: Validity and reliability analyses will be performed using Cognitive Exercise Therapy Approach Biopsychosocial Questionnaire, Patient Health Questionnaire-9, Patient Health Questionnaire-15, Generalized Anxiety Disorder-7, Short Form-36, Craniomandibular Pain and Disability Inventory, and Mandibular Function Impairment Questionnaire.
Study NCT04341155 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Dexamethasone
Description: Patients in experimental arms will receive i.v. dexamethasone 20 mg (4 ampules = 20mL) for 7 days
Study NCT04341155 — intervention group
Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Patients in placebo arms will receive 20 mL normal saline intravenously for 7 days
Study NCT06022614 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Use Bupivacaine 0.25% Injectable Solution
Description: Group A Patients receiving 20 ml Bupivacaine 0.25% added to 1 ml normal saline.
Study NCT06022614 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Bupivacaine 0.25% Injectable Solution plus Dexmedetomidine
Description: Group B Patients receiving 20 ml Bupivacaine 0.25% added to 1 ml dexmedetomidine
Study NCT05136339 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Community-based mentoring and education sessions
Description: Community-based mentoring and education sessions, group activities, and application of a community toolkit for healthy weight loss delivered by trained Health Promoters from Hispanic and Somali communities to their social networks.
Study NCT05224960 — intervention group
Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: UC-MSCs
Description: 3 doses of UC-MSCs intravenously at day 1, day 8, day 15.
Study NCT05224960 — intervention group
Intervention type: BIOLOGICAL
Group type: PLACEBO_COMPARATOR
Intervention: Placebo(solution without UC-MSCs)
Description: 3 doses of placebo intravenously at day 1, day 8, day 15.
Study NCT04464720 — intervention group
Intervention type: BEHAVIORAL
Group type: OTHER
Intervention: Cooking Ventilation Intervention
Description: An educational video presentation for the families regarding the importance of ventilation use during and after cooking, and strategies for improving the ventilation during cooking, has been created by Dr. Holm, with input from Youth Research Assistants (YRAs) The youth involvement will help to ensure that the information is presented in a way that will resonate with the local community and will also provide the youth with exposure to developing health education tools. The educational video will be shown to families at the time of the intervention visit and they will receive printed reminder materials of what they have learned.
Study NCT05295732 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: TMB-001
Description: Topical TMB-001 0.05% QD/BID
Study NCT05295732 — intervention group
Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Matching Vehicle
Description: Topical Vehicle
Study NCT05097768 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Dexamethasone 0.5mg
Description: The patients will be randomly given the medication by mouth 60 min before administering IANB.
Study NCT05097768 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Ketorolac 10 Mg Oral Tablet
Description: The patients will be randomly given the medication by mouth 60 min before administering IANB.
Study NCT05097768 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Meloxicam 7.5 mg
Description: The patients will be randomly given the medication by mouth 60 min before administering IANB.
Study NCT05097768 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Ibuprofen 600 mg
Description: The patients will be randomly given the medication by mouth 60 min before administering IANB.
Study NCT05097768 — intervention group
Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: The patients will be randomly given the medication by mouth 60 min before administering IANB.
Study NCT05730530 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Nutrition education curriculum
Description: This intervention consists of a 6-week-long nutrition education curriculum aimed at improving fruit and vegetable acceptance and consumption. Sessions will occur within the classroom 3 times per week for 6 weeks. Each week, the sessions will consist of 2 days of teaching activities and 1 day of taste-test activities designed for children to guess various common fruits and vegetables, assemble recipes including 2-4 different fruits and vegetables, and then taste the foods. These activities will be conducted in a full-classroom group setting.
Study NCT05764291 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: FIT-TEENS
Description: FIT-TEENS is a digital behaviour change intervention which provides information on physical activity and behaviour change support towards physical activity, presented in multimedia format through an online learning platform (EdApp). The contents is developed in Malay language and consist of 10 self-paced modules and activities. The objectives of FIT-TEENS are for the participants to be able to 1) review the definitions and health benefits of physical activity 2) provide an overview of physical activity guidelines 3) write a SMART goal about physical activity 4) be aware of barriers to physical activity and how to overcome them.
Study NCT05553158 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Compression pants
Description: Similar to compression stockings for the legs which are designed to apply pressure to improve venous return in the legs, compression pants have been designed to apply pressure to pelvic veins to improve the symptoms of Pelvic Congestion Syndrome.
Study NCT05553158 — intervention group
Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Embolization coils
Description: Embolization coils are used to block the veins they are positioned in. This is a standard treatment offered to patients at The Whiteley Clinic.
Study NCT05714995 — intervention group
Intervention type: OTHER
Intervention: hypnosis
Description: The hypnosis session involves the following steps:~1. Preparation for the activation of the hypnotic trance~2. Activation of the hypnotic trance~3. Deepening the hypnotic trance~4. Maintaining hypnotic trance~5. Coming out of the hypnotic trance
Study NCT05714995 — intervention group
Intervention type: OTHER
Intervention: Hypnosis with aromatherapy
Description: for patients in the hypnosis with aromatherapy group, before starting the hypnosis session, they will first choose an essential oil among the 5 proposed.~They will pour a drop on their wrist then they will rub it and inhale deeply.~The hypnosis session involves the following steps:~1. Preparation for the activation of the hypnotic trance~2. Activation of the hypnotic trance~3. Deepening the hypnotic trance~4. Maintaining hypnotic trance~5. Coming out of the hypnotic trance
Study NCT06447064 — intervention group
Intervention type: OTHER
Intervention: Cases & Controls
Description: Participants will complete a brief online questionnaire at REDCap about their health, clinical history and lifestyle choices. The participant will need to provide a photo ID and utility bill for ID verification. After recruitment the participants purchase history in the past 6 years will be requested from the retailers.
Study NCT05958329 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: HRV Biofeedback
Description: 5 minute daily sessions of HRV biofeedback
Study NCT05315284 — intervention group
Intervention type: PROCEDURE
Group type: OTHER
Intervention: the Use of Titanium Elastic Nail in The Fixation of Fresh Non-comminuted Fracture Mid-shaft Clavicle
Description: Fixation of Fresh Non-comminuted Fracture Mid-shaft Clavicle
Study NCT06026319 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: CD79b-19 CAR T cells
Description: Intravenous infusion
Study NCT06026319 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Cyclophosphamide
Description: Intravenous infusion
Study NCT06026319 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Fludarabine
Description: Intravenous infusion
Study NCT05781893 — intervention group
Intervention type: OTHER
Intervention: Digital intervention (DiLCoS)
Description: The DiLCoS substudy comprises a digital intervention. A smartphone app is used to provide the patient with a 12-week exercise program, including physical elements (in the form of breathing exercises, relief positions and relaxation techniques), psychoeducational elements (e.g., information about fatigue, neurocognitive symptoms, media consumption, healthy diet), self-monitoring elements (activity planning, energy management), and psychological elements (e.g., guided exercises to improve acceptance of current situation, cognitive distancing from negative thoughts, imagination techniques for pain management). It holds promise for significantly improving the management and quality of life of individuals living with PCC.
Study NCT05781893 — intervention group
Intervention type: OTHER
Intervention: Data collection
Description: Data collection on sociodemography, clinical data (retrieved from regular care for PCC in the UHB medical outpatient clinic), biomarkers derived from blood samples, neurocognitive testing, psychometric questionnaires, and measures of physical performance.
Study NCT05176782 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: HTK cardioplegia
Description: will receive HTK cardioplegia in volume 30 ml/Kg given by antegrade route through an aortic route cannula.
Study NCT05176782 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Cold Cadioplegia
Description: as the will receive group cold Blood Cardioplegia in volume 20mL/kg given by antegrade route through an aortic route cannula and repeated 10mL/kg/dose every 25minutes at 8-12°C for maintenance. This technique considered the standard management in this age.
Study NCT06317519 — intervention group
Intervention type: PROCEDURE
Intervention: Physical Rehabilitation
Description: 5 sessions of physical rehabilitation per week. Each session lasting 45 minutes. Overall 20 sessions = 4 weeks.
Study NCT06317519 — intervention group
Intervention type: DEVICE
Intervention: Gait Real-time Analysis Interactive Lab
Description: 5 sessions of GRAIL assisted rehabilitation per week. Each session lasting 45 minutes. Overall 20 sessions = 4 weeks.
Study NCT04658303 — intervention group
Intervention type: DRUG
Intervention: Pimonidazole
Description: Pimonidazole is not used with therapeutic intent, and has a non-hazardous designation. It has been widely used for in-vivo evaluation of intratumor hypoxia, and patients will take PO pimonidazole before the scheduled biopsy. Patients receive an oral dose of pimonidazole, a safe chemical tracer up to 24 hours prior to biopsy. Pimonidazole allows for true hypoxia staining; pimonidazole binds hypoxic proteins covalently, creating an antigen that facilitates the imaging, flow cytometry, and scRNA-seq experiments proposed. Pimonidazole has been previously used in patients and is safe and well tolerated, without anticipated adverse events.
Study NCT05627401 — intervention group
Intervention type: PROCEDURE
Intervention: Modified multiple orbital wall decompression
Description: Thyroid dysfunction of all patients is stabilized by ATDs until treatment of TAO is completed. All patients with sight-threatening GO were admitted for emergency steroid pulse therapy. And additional drugs for protecting gastrointestinal mucous membrane, potassium and calcium supplements, and sedatives were used. All emergency cases, whose signs of visual impairment clinically attributable to GO existed despite first-line steroid treatment, were referred and discussed at the surgical board of our interdisciplinary center for prompt surgical orbital decompression. Urgent orbital decompression was performed when response is absent or poor within 1-2 weeks.
Study NCT04703634 — intervention group
Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: erector spinae block (ESP)
Description: Administration of local anesthetic under the erector spinae muscle just below the transverse process of the thoracic 12th vertebra
Study NCT04703634 — intervention group
Intervention type: PROCEDURE
Group type: PLACEBO_COMPARATOR
Intervention: erector spinae block (ESP)
Description: Administration of local anesthetic under the erector spinae muscle just below the transverse process of the thoracic 12th vertebra
Study NCT04930107 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Fluconazole 150 mg
Description: Treatment will be offered to participants if clinical exam and clinical samples are consistent with vulvovaginal candidiasis (VVC). Females presenting with a suspected first-time yeast infection will be treated with fluconazole 150 mg orally.
Study NCT04930107 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Boric Acid Supp,Vag
Description: Treatment will be offered to participants if clinical exam and clinical samples are consistent with vulvovaginal candidiasis (VVC). Women that have had a prior documented VVC infection that has recurred on fluconazole will be treated with boric acid, 600 mg intravaginally at bedtime for 7 days.