AIM-Harvard/TrialPanorama-filtered huggingface dataset:
Study NCT06029348 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Paced Auditory Serial Addition Task
Description: Study volunteers will be asked to complete a 4-minute Paced Auditory Serial Addition Task, which is a standardized task that is widely used to study cardiovascular responses to acute psychological challenges (or stressors) in a laboratory setting.
Study NCT06422819 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Heart rate variability Biofeedback [HRV-BFB]
Description: Biofeedback (BFB), sometimes referred to as biological feedback technique, is a non-invasive and non-pharmacological approach based on physiological recordings that provide real-time feedback enabling people to learn how to control their physiological processes, which are typically unconscious and beyond their control. HRV-BFB specifically targets heart rate variability (HRV), which can help regulate the autonomic nervous system (including vagal tone and sympathetic-parasympathetic balance) as well as emotional states. HRV-BFB has been clinically and experimentally validated as a physiological intervention and has demonstrated its effectiveness. However, it has never been studied in an adult FND population.
Study NCT06422819 — intervention group
Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Pseudo HRV-BFB
Description: The pseudo HRV-BFB intervention aims to implement the same HRV BFB methods with no specific effect on HRV.
Study NCT05806580 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Relma-cel
Description: Patients who have undergone at least one disease assessment after initial Relma-cel treatment and have not achieved complete remission may receive a second treatment based on clinical practice. The specific dosage will be determined by the investigator according to the patient's condition and available dose reserves.
Study NCT05919186 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: EmbryORP®
Description: EmbryORP® is a novel antioxidant (Cystein 32.9 mM, Glutation 32.6 mM, Ascorbic Acid 22.7 mM)
Study NCT05919186 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: O2 tension 20%
Description: After fertilization check, zygotes were placed in the incubator at 37°C, 8% CO2, and 95%
Study NCT05919186 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: O2 tension 5%
Description: After fertilization check, zygotes were placed in the incubator at 37°C, 8% CO2 and 95%
Study NCT05176535 — intervention group
Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: FertyBiotic Balance
Description: Lactobacillus rhamnosus BPL 205, Lactobacillus plantarum BPL207 and Lactobacillus crispatus BPL209
Study NCT06035016 — intervention group
Intervention type: DRUG
Intervention: pyrotinib combined with Capecitabine
Description: Pyrotinib 400mg, qd, po, day 1-21, q3w, Capecitabine 1000mg/m2, bid po d1-14, q3w
Study NCT06035016 — intervention group
Intervention type: DRUG
Intervention: treatment of physician's choice
Description: Treatment of physician's choice
Study NCT05361668 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Randomized: 40 mg Paltusotine
Description: Two 20 mg tablets QD (Potential post-randomization dose escalation based on efficacy and acceptable tolerability: up to 80 mg)
Study NCT05361668 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Randomized: 80 mg Paltusotine
Description: Four 20 mg tablets QD (Potential post-randomization dose escalation based on efficacy and acceptable tolerability: up to 120 mg)
Study NCT06508190 — intervention group
Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: continuous positive airway pressure
Description: continuous positive airway pressure therapy for a period of 12 weeks, all patients with in this group are required to utilize the CPAP machine for at least 4 hours each night
Study NCT06508190 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: free walking exercise and continuous positive airway pressure
Description: patients will receive continuous positive airway pressure therapy for a period of 12 weeks, all patients with in this group are required to utilize the CPAP machine for at least 4 hours each night. Also, patients will perform walking exercise for 30 mint, daily for 12 weeks
Study NCT06473740 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Deoxyribonucleic acid supercoiled plasmid pCMV-VEGF165 (Neovasculgen)
Description: The drug Neovasculgen is a highly purified supercoiled form of the pCMV-VEGF165 plasmid, encoding the Vascular endothelial growth factor (VEGF) under the control of a promoter (DNA control region). Recombinant plasmid DNA consists of the following components: a fragment of the regulatory region (22 nucleotide pairs), which determines the transcription of the gene, the VEGF minigene, upon expression of which the VEGF isoform is synthesized, consisting of 165 amino acids, a splicing signal, a polyadenylation signal and the SV40 transcription terminator, ensuring the synthesis of the mature RNA gene and auxiliary regions required for efficient biosynthesis of plasmid DNA in the cells of the producer strain of Escherichia coli. When molecules of this plasmid penetrate into mammalian cells, VEGF is produced, which stimulates endothelial cells, which leads to the growth of blood vessels (vascularization) in the area of injection.
Study NCT05618977 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Dramatization simulation
Description: Ethical attitudes of nursing students will be evaluated with dramatization simulation application.
Study NCT05618977 — intervention group
Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: In-class case studies
Description: In-class case studies will be conducted with the control group students.
Study NCT05798767 — intervention group
Intervention type: BEHAVIORAL
Intervention: Neuropsychological tests
Description: Cognitive function screening (Mini-Cog; the Mini-mental State Examination, MMSE), depression screening (Patient Health Questionnaire-9, PHQ-9), sleep quality assessment (Pittsburgh Sleep Quality Index, PSQI), and pain assessment (Numeric Rating Scale, NRS) were performed the day before surgery.~The Short Confusion Assessment Method (CAM) was administered once per day on postoperative days 1 to 5 to evaluate delirium.
Study NCT05674331 — intervention group
Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Extraction site development technique
Description: The technique is described by Molnar et al. in 2019. The aim is to reconstruct the buccal bony wall with a xenogenic membrane with a slow absorption rate properties. This technique aims to stabilizate and enlarge the blood clot .
Study NCT05674331 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: autogenous tooth bone graft
Description: ATB was invented by Kim et al. in 2011. The extracted tooth is grinded and goes throw a sterilization procedure by the manufacturer's recommendation. The graft material can be used immediately for ARP.
Study NCT05674331 — intervention group
Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Socket seal technique
Description: After tooth removal neither graft nor any membrane material is inserted to the extraction socket. A soft tissue pounch is harvested from the hard palate and it is fixed above the extraction socket with single interrupted sutures.
Study NCT05674331 — intervention group
Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Socket seal technique
Description: After tooth removal neither graft nor any membrane material is inserted to the extraction socket. A soft tissue pounch is harvested from the hard palate and it is fixed above the extraction socket with single interrupted sutures.
Study NCT05438017 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Dreem 3 System vs PSG
Description: Dreem 3 System to be worn by each participant while undergoing in-lab sleep study with PSG.
Study NCT06189521 — intervention group
Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Extracorporeal shock wave group
Description: In addition to the ten-day of physiotherapy program, in the first group one day for a week a total of 3 sessions of ESWT was applied at 1.8 bar, 10.0 Hz, 2000 beats (Elmed Vibrolith Ortho).
Study NCT06189521 — intervention group
Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: ultrasound group
Description: In addition to the ten-day of physiotherapy program,In the second group, ten days of ultrasound applied at 1.5 watt/cm2 continuous mode to the painful area for 5 minutes, 5 days a week for two weeks (Chattanooga Intelect Advanced).
Study NCT06189521 — intervention group
Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: dexamethasone iontophoresis group
Description: In addition to the ten-day of physiotherapy program, In the third group ten days of dexamethasone iontophoresis therapy was applied. 10 days for 10 minutes. 0,1% dexamethasone ophthalmic pomade was applied to the anodal electrode and placed on the lateral epicondyle and 0.1-0.2 milliampere/cm2 galvanic current was applied in each session (ES-522; ITO Physiotherapy and Rehabilitation).
Study NCT06318949 — intervention group
Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: blood sampling
Description: If the patient does not object to participating in the study, a blood sample is taken at each visit (an additional tube may be added to a routine blood sample taken for standard care), or a residual blood sample is reused after routine tests have been performed, and data is collected from the medical record.
Study NCT06450938 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: AI guidance for finding radiographic features
Description: A secured website was made for the trial in which each student could log in using the assigned number. All the image datasets were uploaded to this website. The students will be randomly assigned to the experiment and control group. Both students were asked to segment the features associated with the quality of root canal treatment and predict the prognosis of treatment while the experiment group had access to AI guidance and the control group didn't.
Study NCT06436027 — intervention group
Intervention type: DIAGNOSTIC_TEST
Intervention: Nano-Heart tool: Intra-Graft Targeted Gene Expression Profiling
Description: Targeted molecular profiling will be performed on formalin-fixed paraffin-embedded (FFPE) endomyocardial biopsies using the NanoString nCounter technology. A consortium-approved consensual targeted panel including 770 genes, developed by the Banff Molecular Diagnostics Working Group (MDWG) will be used.
Study NCT05218187 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: G-EO End-Effector Gait Trainer
Description: The G-EO Gait Trainer uses distal fixation to promote a gait recovery by facilitating a controlled walking environment that includes an over-ground pattern and stair climbing. In addition, the device provides body position control to enable the patient to concentrate on the cyclical motion of walking without the fear of falling. Physical therapists can control different parameters of the gait cycle through computerized adjustments and the training setting can be manipulated to engage patients in active participation.
Study NCT05218187 — intervention group
Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Conventional Physical Therapy Treatment
Description: Therapists will use traditional methods of neurological rehabilitation for improved gait and balance. These approaches will include stretching, strengthening, therapeutic exercises, balance training, and over-ground walking
Study NCT05218187 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Conventional Physical Therapy Treatment
Description: Therapists will use traditional methods of neurological rehabilitation for improved gait and balance. These approaches will include stretching, strengthening, therapeutic exercises, balance training, and over-ground walking
Study NCT04762823 — intervention group
Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Cerebellar transcranial direct current stimulation at 4 mA
Description: Uses weak electrical current (4 mA intensity) to either increase or decrease brain excitability and improve functional or cognitive outcomes.
Study NCT04762823 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Cerebellar transcranial direct current stimulation at 4 mA
Description: Uses weak electrical current (4 mA intensity) to either increase or decrease brain excitability and improve functional or cognitive outcomes.
Study NCT04762823 — intervention group
Intervention type: DEVICE
Group type: SHAM_COMPARATOR
Intervention: Sham cerebellar transcranial direct current stimulation
Description: Uses weak electrical current (4 mA intensity) at the beginning and the end of a given stimulation period to control for potential placebo effects or participant expectation bias.
Study NCT05334745 — intervention group
Intervention type: OTHER
Group type: OTHER
Intervention: Alvogyl
Description: application of Alvogyl in the palatal wound with stent versus hyaluronic acid application
Study NCT05334745 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Alvogyl
Description: application of Alvogyl in the palatal wound with stent versus hyaluronic acid application
Study NCT05496946 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Head bathing skill
Description: A group of students will practice the head bathing skill in a model with low proximity to reality, while the students in the other group will practice on a healthy individual (Standardized patient) pretending to be patient.
Study NCT06409520 — intervention group
Intervention type: DIAGNOSTIC_TEST
Intervention: thyroid function tests
Description: (TSH, free T4) The normal ranges of thyroid function tests were 0.40-4.99 mIU/L for TSH and 0.7-1.8 ng/dL for free T4. The same testing method will performed on all samples from all patients.
Study NCT06409520 — intervention group
Intervention type: DIAGNOSTIC_TEST
Intervention: cardiac enzymes
Description: troponine
Study NCT06409520 — intervention group
Intervention type: DIAGNOSTIC_TEST
Intervention: ECG
Description: Electrocardiogram
Study NCT05293210 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Dexamethasone
Description: A daily dose of dexamethasone 20 mg intravenous for 3 days, followed by a daily dose of dexamethasone 6 mg intravenous or oral for 7 days.~Dexamethasone 6 mg orally or intravenously for 10 days (with the possibility of escalation to doses of 20 mg daily of oral or intravenous dexamethasone for 3 days if clinical criteria of respiratory distress develop despite treatment with doses of dexamethasone 6 mg daily).
Study NCT05293210 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Dexamethasone
Description: A daily dose of dexamethasone 20 mg intravenous for 3 days, followed by a daily dose of dexamethasone 6 mg intravenous or oral for 7 days.~Dexamethasone 6 mg orally or intravenously for 10 days (with the possibility of escalation to doses of 20 mg daily of oral or intravenous dexamethasone for 3 days if clinical criteria of respiratory distress develop despite treatment with doses of dexamethasone 6 mg daily).
Study NCT05740735 — intervention group
Intervention type: OTHER
Intervention: Use of expressive sounds
Description: Use of expressive sounds, that is to say the own first name pronounced by the voice of the relative to generate the P300 and a sound with an approaching character of the subject to generate the MMN.~The investigators will thus be able to compare:~* MMN: present/absent for each modality (neutral vs approaching sounds)~* Wave P3a: latencies and amplitudes for each modality (own first name voice of the near vs unfamiliar).
Study NCT05740735 — intervention group
Intervention type: OTHER
Intervention: Having benefited from a prognostic evaluation by event related potentials (without sound research methods, only neutral sounds)
Description: Retrospective inclusion Have already had an assessment with event related potentials without emotional modalities (VF and similar sounds) as part of their care between April 2022 and December 2022 in intensive care at Cochin hospital.
Study NCT06082583 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Remote Ischemic Conditioning
Description: Remote ischemic conditioning conducted by an electric auto-control device will be performed twice a day for 14 days, each session including 5-min ischemia and 5-min reperfusion.
Study NCT06082583 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Tibetan Medicine (Shiliu Jianwei Powder, Ershiwuwei Yuganzi Pills, Qiwei Tiexue Pill)
Description: Comprehensively Tibetan medicine for 28 days, including Shiliu Jianwei Powder, Ershiwuwei Yuganzi Pills and Qiwei Tiexue Pill, dosage of which are 1.5g daily.
Study NCT06082583 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Tibetan Medicine (Shiliu Jianwei Powder, Ershiwuwei Yuganzi Pills, Qiwei Tiexue Pill)
Description: Comprehensively Tibetan medicine for 28 days, including Shiliu Jianwei Powder, Ershiwuwei Yuganzi Pills and Qiwei Tiexue Pill, dosage of which are 1.5g daily.
Study NCT04984954 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: MUSK pill
Description: This is a multicenter, randomized, double-blind, placebo-controlled clinical trial. Patients were treated with the trial drug or placebo in a 1:1 ratio. The experimental group was treated with MUSK pill (4 pills / day, 3 times / day) on the basis of conventional treatment until the end of follow-up
Study NCT04984954 — intervention group
Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: MUSK pill
Description: This is a multicenter, randomized, double-blind, placebo-controlled clinical trial. Patients were treated with the trial drug or placebo in a 1:1 ratio. The experimental group was treated with MUSK pill (4 pills / day, 3 times / day) on the basis of conventional treatment until the end of follow-up
Study NCT04513184 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: IV Dexamethasone
Description: 6 mg from Day 1 to 10 after randomization
Study NCT04513184 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Nasal Dexamethasone
Description: 0.12 mg/kg/daily for 3 days from day 1, followed by 0.06 mg/kg/daily from day 4 to 10 after randomization.
Study NCT06346418 — intervention group
Intervention type: GENETIC
Group type: EXPERIMENTAL
Intervention: WES analysis
Description: Whole-exome sequencing will be performed as the first approach in all the recruited patients. First, we will analyze different subsets of genes, belonging to:~1. Maternal effect genes as SCMC components and other related genes;~2. Genes essential in the maturation of the oocyte and zygote progression through the early phases of the embryogenesis or highly expressed at different stages of oocyte maturation;~3. Genes with known and potential roles in the establishment and control of genomic imprinting and involved in DNA methylation reactions.~Subsequently, variants with a high pathogenicity score will be analyzed, to identify any genes that may be associated with the phenomenon, but do not belong to the previously described categories of genes. Finally, we will conduct a whole genome sequencing (WGS) analysis on a selected subgroup of BWS mothers with peculiar clinical histories and negative WES analysis, to explore all the noncoding and regulatory regions not targeted by WES.
Study NCT06346418 — intervention group
Intervention type: GENETIC
Group type: EXPERIMENTAL
Intervention: whole-genome methylation analysis
Description: A whole-genome methylation analysis will be performed to identify methylation changes in women with reproductive problems including those with offspring affected by BWS
Study NCT06442319 — intervention group
Intervention type: BIOLOGICAL
Group type: ACTIVE_COMPARATOR
Intervention: Platelet-rich plasma
Description: Platelet-rich plasma intra-articular injection in patients after anterior cruciate ligament reconstruction
Study NCT06442319 — intervention group
Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Platelet-rich plasma
Description: Platelet-rich plasma intra-articular injection in patients after anterior cruciate ligament reconstruction
Study NCT04895683 — intervention group
Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Text message content
Description: Behavioural science-informed text messages aimed at improving COVID-19 vaccination uptake.
Study NCT04895683 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Text message content
Description: Behavioural science-informed text messages aimed at improving COVID-19 vaccination uptake.
Study NCT05220384 — intervention group
Intervention type: BEHAVIORAL
Group type: OTHER
Intervention: In-person Motivational Interview combined with Self-Management techniques
Description: This is an approximately 30 mins in-person, semi-structured, semi-personalized physical activity focused Motivational Interviewing treatment with self-management techniques. (This therapy is an add on to the usual therapy that is given to the adolescents who present at the hospital.) During the interactive treatment a self-management workbook will be filled out by the adolescent for the purpose of further data collection. This in-person therapy at the hospital is followed by two booster sessions via phone at the 1st week post meeting date and 1 month post meeting date.
Study NCT05220384 — intervention group
Intervention type: BEHAVIORAL
Group type: OTHER
Intervention: Video-based Motivational Interview combined with Self-Management techniques
Description: This is a series of three videos comprising a structured activity focused Motivational Interviewing treatment with self-management techniques. The videos' thematic follow the semi-structured interview elements to ensure that it is a true sham of the in-person one. (This therapy is an add on to the usual therapy that is given to the adolescents who present at the hospital.) This first video is going to be watched by adolescents at the hospital. During the interactive video-treatment a self-management workbook will be filled out by the adolescent for the purpose of further data collection. The second video is going to be sent to the participants via e-mail on the 1st week post meeting date and the third video is on the 1-month post meeting date.
Study NCT05127629 — intervention group
Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Immediate implant placement
Description: After tooth extraction, a dental implant is placed immediately.
Study NCT05127629 — intervention group
Intervention type: PROCEDURE
Group type: PLACEBO_COMPARATOR
Intervention: Immediate implant placement
Description: After tooth extraction, a dental implant is placed immediately.
Study NCT05127629 — intervention group
Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Guided bone regeneration
Description: After implant placement, the gap between implant and the buccal bone wall is filled with Bio-oss collagen.
Study NCT05127629 — intervention group
Intervention type: PROCEDURE
Group type: PLACEBO_COMPARATOR
Intervention: Guided bone regeneration
Description: After implant placement, the gap between implant and the buccal bone wall is filled with Bio-oss collagen.