AIM-Harvard/TrialPanorama-filtered huggingface dataset:
Study NCT05499156 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: placenal MSC derived exosomes
Description: placenta-MSCs derived exosomes Exosomes are extracellular vesicles that are 30 to 150 nm in diameter. these vesicles are secreted from various cells. Mesenchymal stem cells exhibit immunomodulatory and anti- inflammatory properties by the use of paracrine effects. Exosomes as a vehicle for signaling, are responsible for a major part of cell to cell signaling. The preclinical animal studies manifested high safety and efficacy for MSC derived exosome treatment on various fistulas and inflammatory bowel disease. In this study we aimed to evaluate the safety and efficacy of PlacentaMSCs derived exosomes in treatment of patients with complex preanal fistula (non-crohn's) in phase I and II of clinical trial
Study NCT05123027 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Peer Intervention to Link Overdose Survivors to Treatment (PILOT) Peer
Description: Participants will meet with the PILOT Peer consistently throughout the 6 months of study participation.
Study NCT05123027 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Treatment As Usual Peer
Description: Participants will receive recovery resources and standard of care procedures specific to the Emergency Department.
Study NCT05123027 — intervention group
Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Treatment As Usual Peer
Description: Participants will receive recovery resources and standard of care procedures specific to the Emergency Department.
Study NCT04916886 — intervention group
Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Recombinant Novel Coronavirus Vaccine (Adenovirus Type 5 Vector) 0.5ml
Description: Containing 0.5E10vp
Study NCT04916886 — intervention group
Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Recombinant Novel Coronavirus Vaccine (Adenovirus Type 5 Vector) 0.3ml
Description: Containing 0.3E10vp
Study NCT05778708 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Tai-Chi intervention
Description: The standardized 16-form Yang-style Tai-Chi exercise set will be adopted. Group classes will take place in a community center twice a week for 16 weeks, with each class lasting approximately 60 minutes. Classes will be taught by an experienced Tai-Chi master. Patients will be instructed to practice the Tai-Chi exercises at home at least 3 times a week (30 min each time for a total of 90 min). Patients will be provided with a daily exercise log to record their exercise type, frequency, and intensity.
Study NCT05778708 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Aerobic exercise intervention
Description: The aerobic exercise class will be designed to cover both aerobic and resistance exercises. Group classes will take place in an exercise center twice a week for 16 weeks, with each class lasting approximately 60 minutes. Each class will be led by a certified exercise specialist. Patients will be provided with a daily exercise log to record their exercise type, frequency, and intensity.
Study NCT00240864 — intervention group
Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: placebo
Study NCT00240864 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: acetaminophen
Study NCT00240864 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ibuprofen
Study NCT04844307 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Shorter duration higher frequency PT
Description: The standard PT session (30 mins) will be divided into two 15 minute sessions spread out during the day. Therefore, the total number of minutes of PT will not vary from the standard.
Study NCT04844307 — intervention group
Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Standard PT
Description: The standard PT session is 30 minutes once daily. It routinely involves exercises designed to strengthen and increase mobility of the patient such as bed mobility, transfers, and ambulation. In this study group there will be no variation from this standard treatment.
Study NCT06274125 — intervention group
Intervention type: PROCEDURE
Intervention: Robotic-Assisted Laparoscopic Radical Prostatectomy
Description: To evaluate kidney damage in patients undergoing robotic radical prostatectomy, NGAL measurement will be performed.
Study NCT05770401 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Internet-Behavioral Cough Suppression Therapy
Description: Participants will access training modules to learn behavioral techniques and will implement them in daily life over a four-week period.
Study NCT05770401 — intervention group
Intervention type: BEHAVIORAL
Group type: SHAM_COMPARATOR
Intervention: Sham Treatment
Description: Participants will access training modules to learn behavioral techniques and will implement them in daily life over a four-week period.
Study NCT05081076 — intervention group
Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Glazing
Description: The zirconia surface will be submitted to a vitrification procedure (glazing) in a specific ceramic oven using the Ceramill Stain \& Glaze Kit, following the manufacturer's instructions.
Study NCT05081076 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Polishing
Description: The zirconia surface will be submitted to a polishing procedure using a polishing rubbers kit in the sequence indicated by the manufacturer (EVE DIACERA Finishing and Polishing Kit, EVE Ernst Vetter GmbH - Germany).
Study NCT04972513 — intervention group
Intervention type: PROCEDURE
Intervention: Biospecimen Collection
Description: Undergo collection of blood
Study NCT04972513 — intervention group
Intervention type: PROCEDURE
Intervention: Nitric Oxide Breath Test
Description: Undergo nitric oxide breath testing
Study NCT04972513 — intervention group
Intervention type: PROCEDURE
Intervention: Oscillometry
Description: Undergo airwave oscillometry
Study NCT04972513 — intervention group
Intervention type: PROCEDURE
Intervention: Spirometry
Description: Undergo spirometry
Study NCT04972513 — intervention group
Intervention type: OTHER
Intervention: Survey Administration
Description: Complete survey
Study NCT04972513 — intervention group
Intervention type: PROCEDURE
Intervention: Endothelial function
Description: Endothelial function will be assessed with the EndoPAT device, which measures changes in pressure from sensors placed on the fingertip
Study NCT04894994 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: FLX475
Description: Tablet
Study NCT04894994 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Ipilimumab
Description: IV infusion
Study NCT04412395 — intervention group
Intervention type: DIETARY_SUPPLEMENT
Group type: ACTIVE_COMPARATOR
Intervention: Lactoferrin (Apolactoferrin)
Description: Apolactoferrin is an iron-free Lactoferrin (with very low iron saturation). Lactoferrin (Lf) is a natural glycoprotein that is found predominantly in milk. Lf represents a known component of the innate immune system present in neutrophil-specific granules and broadly distributed within the body fluids and exocrine secretions.
Study NCT04229797 — intervention group
Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Mandibular distalization using extra-radicular miniscrews
Description: Distalization of the Mandibular first molars using mandibular buccal shelf mini-screws in the presence of unerupted third molars
Study NCT04229797 — intervention group
Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Mandibular distalization using extra-radicular miniscrews
Description: Distalization of the Mandibular first molars using mandibular buccal shelf mini-screws in the presence of unerupted third molars
Study NCT05386745 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: physical activity
Description: A series of 10 weekly psychoeducational modules including information on psychosocial determinants of physical activity engagement, adherence and maintenance, as well as a number of other behaviour change tools, like reflection activities.
Study NCT04412395 — intervention group
Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo of excipient(s) will be administered
Description: Placebo of the equivalent excipient will be administered to placebo group
Study NCT05927805 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: E-bibliotherapy
Description: Participants in the intervention group will accept eight weekly sessions of e-bibliotherapy. The e-bibliotherapy will be delivered via the e-bibliotherapy app we develop and includes eight e-bibliotherapy sessions, each focusing on one active component that may affect a caregiver's mental well-being.
Study NCT05927805 — intervention group
Intervention type: OTHER
Group type: SHAM_COMPARATOR
Intervention: Control
Description: The control group will give access to the same e-bibliotherapy app, but only be authorized to access general daily living knowledge that is different from the intervention contents. They will also be asked to finish a session each week for eight weeks.
Study NCT06396871 — intervention group
Intervention type: DIAGNOSTIC_TEST
Intervention: Oral glucose tolerance test
Description: 75g of a standardized glucose solution followed by blood draw at 0, 30, 60, 90, 120 min
Study NCT06396871 — intervention group
Intervention type: DIAGNOSTIC_TEST
Intervention: Liver Ultrasound
Description: A crude assessment of liver status in order to identify the presence of steatosis or not will take place with ultrasound.
Study NCT05401331 — intervention group
Intervention type: DEVICE
Group type: OTHER
Intervention: Treadmilll
Description: Hemodynamic changes before and after treadmill use
Study NCT05401331 — intervention group
Intervention type: OTHER
Group type: OTHER
Intervention: mask
Description: mask
Study NCT05789680 — intervention group
Intervention type: PROCEDURE
Intervention: Surgical treatment of parathyroid carcinoma
Description: Radical treatment of suspected parathyroid carcinoma should consist of parathyroidectomy and en bloc ipsilateral hemithyroidectomy and central lymph node dissection.
Study NCT05934279 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Resistance Training
Description: All training exercise involve balance and strength improvement. Consist of 8 weeks of trainings per 2 trainings in each week, ongoing 45 minutes.
Study NCT06396871 — intervention group
Intervention type: DIAGNOSTIC_TEST
Intervention: Fibroscan of the Liver
Description: FibroScan non-invasively measures the stiffness of the liver by capturing and calculating the speed of a shear wave as it travels through the liver (vibration controlled transient elastography).
Study NCT05415982 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Ketogenic Diet
Description: The intervention is a ketogenic diet based on high-fat ketogenic meals prepared by the study participants, complemented with ketogenic food products from Natural Ketosis and Vitaflo. Exogenous ketones are provided by Audacious Nutrition. The macronutrient composition of the ketogenic diet given approx.: Fat 87 E%, Carbohydrate 3 E%, Protein 10 E%,
Study NCT06432205 — intervention group
Intervention type: PROCEDURE
Intervention: surgery
Description: any forms of surgery, such as all tumor resection, partial tumor resection and palliative tumor resection surgery
Study NCT04908722 — intervention group
Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Ad26.COV2.S
Description: Participants will receive intramuscular (IM) injections of Ad26.COV2.S.
Study NCT05600179 — intervention group
Intervention type: DRUG
Intervention: Dexamethasone intravitreal implant
Description: Dexamethasone intravitreal implant
Study NCT05131490 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: A mobile application intervention developed for gynecological cancer patients receiving chemotherapy
Description: The mobile application will consist of modules. It is planned to include four education modules and consultancy modules in the application.~1. Module 1: It will consist of sub-categories with information to be prepared in line with the current literature on gynecological cancer types and treatments applied. There will be information and short videos that will strengthen coping with physical symptoms, especially from chemotherapy.~2. Module 2: In this area, there will be meditation and relaxation/breathing exercises, information on relaxing complementary therapies, anxiety reduction and stress management techniques videos and audio recordings.~3. Module 3: Current developments on gynecological cancers will be included.~4. Module 4: Encouraging recovery stories and videos of cancer survivors will be included.~5. Module 5: Counseling module. This is the area where patients who cannot find answers in the frequently asked questions section can ask questions to the research team.
Study NCT04655482 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Aflibercept Injection
Description: Intravitreal injection of aflibercept using treat-and-extend regimen~:Three monthly loading injections followed by proactive treatment using TAE regimen. Extension of injection interval by 2 weeks. The maximum injection interval was set as 16 weeks.
Study NCT05339828 — intervention group
Intervention type: PROCEDURE
Intervention: unroofing curettage
Description: Surgery was performed with the patient lying in the prone position under local anesthesia. The tract was identified by passing small artery forceps along its length and was then opened by cutting directly down onto the forceps. The sinus and all its tracts were completely unroofed, and the base was curetted to remove all necrotic content, hair, and granulation tissue using a dry gauze. The fibrotic back wall was left as intact as possible to avoid delayed healing. Hemostasis was achieved using diathermy with no drainage needed.
Study NCT06396871 — intervention group
Intervention type: DIAGNOSTIC_TEST
Intervention: Magentic Resonance Imaging (MRI) of the liver
Description: The exact calculation of liver fat with proton density fat fraction will take place with MRI.
Study NCT04391049 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Carboplatin
Description: Given IV
Study NCT04391049 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Paclitaxel
Description: Given IV
Study NCT04391049 — intervention group
Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: Radiation Therapy
Description: Undergo radiation therapy
Study NCT04391049 — intervention group
Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Telomerase-specific Type 5 Adenovirus OBP-301
Description: Given by intratumoral injection
Study NCT06372730 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Ventilation/Perfusion Single Photon Emission Computed Tomography (V/Q SPECT/CT)
Description: All patients will undergo a V/Q SPECT/CT scan at inclusion.
Study NCT04562168 — intervention group
Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Autoderm® dermatology search engine (ML model) testing
Description: GP using a smartphone camera will take an image of the skin problem and will use the Autoderm ML interface to upload the anonymized image. The obtained predicted diagnosis will be recorded in case report form.
Study NCT05661474 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Fitostimoline ® hydrogel group
Description: Treatment of DFUs with Fitostimoline® hydrogel every day for 12 weeks.
Study NCT05661474 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Saline gauze group
Description: Treatment of DFUs with saline gauze every day for 12 weeks.
Study NCT05481762 — intervention group
Intervention type: DEVICE
Intervention: Aided read with contextflow DETECT Lung CT
Description: Radiologists read chest CT scabs with and without the aid of contextflow DETECT Lung CT as a second reader
Study NCT04965844 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Oxygen close-loop
Description: The Automatic FiO2 option provides automated adjustment of the ventilator Oxygen setting to maintain the patient's SpO2 in a defined target range. When using the software option, the user defines the SpO2 target range, as well as the SpO2 emergency limits, and the device adjusts the Oxygen setting to keep the patient's SpO2 in the target range.
Study NCT04965844 — intervention group
Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: No intervention
Description: Manual FiO2 adjustment according to SpO2 values
Study NCT05103267 — intervention group
Intervention type: DEVICE
Intervention: Tauropace
Description: TauroPace™ contains disinfecting substances to eradicate environmental microbial contamination on the surface of cardiac implantable electronic devices (CIEDs). The surface of the CIED is moistened with TauroPace™ during the implantation procedure to create a hostile environment on the surface of the CIED.
Study NCT05139407 — intervention group
Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Teaching intervention
Description: Different teaching methods are used to teach the experimental group and the control array in the classroom.
Study NCT05189561 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: near-infrared scanner
Description: Tests to be administered: Near Infra-Red Scanning of the head at the bedside.~Time taken for testing: Two minutes~Biological samples collected: None~Frequency of testing/collection: Once~Risks for the participants while being tested: None
Study NCT06529874 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Pressure pain tolerance measurement using Digital Pressure Algometer
Description: Pressure pain tolerance will be measured using pressure algometer for all participants in both groups. Pressure pain tolerance will be measured in a relaxed sitting position to evaluate on quadriceps muscle. Initially, a teddy bear will be used for demonstration.
Study NCT06529874 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Balance assessment using HUMAC balance system
Description: HUMAC balance system will be calibrated, then will conduct~1. center of pressure: will instructed child to stand on platform, and maintain own body stability, and focus on the red dot in the center of screen that will move in response to body sway. after a rest, second trial will be done.~2. Eye open/ closed firm surface tests: First for Eye open firm surface test; the child will be asked to look at a target on the wall that was set at his/ her eye level, and to stare at this target for 30 seconds while standing on firm surface. After 5 seconds rest. Eye closed firm surface test; child will be asked to close his/ her eyes for 30 seconds, and conducting the same procedures for balance testing.~The researcher will documented the values resented on the screen .
Study NCT06529874 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Lower limb muscular strength using Lafayette hand held dynamometer
Description: Lower limb muscular ' Isometric quadriceps strength' will be measured for all participants in both groups. each participating child will be instructed to sit to assess the strength of knee extension, which minimize positional changes, and enhance feasibility of this clinical test. then The researcher will apply resistance to child's quadriceps to gain maximal voluntary isometric contraction with pressing the activated Lafayette hand held dynamometer padded stirrup against quadriceps belly, then recorded and documented measured value.
Study NCT05605028 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Mental Health lifestyle intervention
Description: The focus is to identify 10 potential groups of causes and working on reversing them. The 10 factors are: (1) Genetic, (2) Developmental, (3) Lifestyle, (4) Circadian Rhythm, (5) Addiction, (6) Nutrition, (7) Toxic, (8) Social/Complicated Grief, (9) Medical Condition, and (10) Frontal Lobe. Each of these factors will be dealt with in the lifestyle intervention.
Study NCT05605028 — intervention group
Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Dietitian-led
Description: A group of people that visit the dietitian will be used as comparison against the Mental Health lifestyle intervention
Study NCT05103397 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: methyl prednisolone
Description: Low dose group .Group (A) 10 mg/Kg methyl prednisolone will be received after induction and before separation to (CPB).
Study NCT05103397 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Methyl Prednisolonate
Description: High dose group.Group (B) 30 mg/Kg will be received after induction and before separation (CPB)
Study NCT05103397 — intervention group
Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Placebo group.Group (C) (25 patients) patients will receive placebo in form of normal saline
Study NCT06529991 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Occipivot suboccipital pillow self-myofascial release
Description: Subjects will be instructed in the use of the Occipivot suboccipital pillow and how it should feel. They will be supervised as it is placed. Once verbal verification is obtained regarding the feel and placement of the wedge, the treatment time will begin and continue for 5 minutes.
Study NCT06471049 — intervention group
Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Benign Hysterectomy
Description: removal of the uterus
Study NCT06471049 — intervention group
Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Benign Hysterectomy
Description: removal of the uterus
Study NCT05057130 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Doxorubicin, Cisplatin, Methotrexate
Description: IV
Study NCT05057130 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Doxorubicin, Cisplatin
Description: IV
Study NCT06534762 — intervention group
Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Mirabegron
Description: To explore the efficacy and safety of milaberon combined with standard treatment in advanced solid tumors
Study NCT06181214 — intervention group
Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: AG1 - Nutritional Supplement
Description: A foundational nutritional supplement consisting of vitamins, minerals, probiotics, prebiotics, and whole food ingredients
Study NCT06181214 — intervention group
Intervention type: DIETARY_SUPPLEMENT
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Maltodextrin placebo
Study NCT05272293 — intervention group
Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: NK cell infusions
Description: Three doses of expanded haploidentical NK cells (30-100 x 10\^6 cells /kg).
Study NCT05204680 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Aerobic Exercise
Description: The participant will work with the physical therapist on an exercise regimen.