AIM-Harvard/TrialPanorama-filtered huggingface dataset:
Study NCT04825288 — intervention group
Intervention type: BIOLOGICAL
Group type: ACTIVE_COMPARATOR
Intervention: XB2001 or Placebo
Description: XB2001 is a True Human monoclonal antibody that blocks the biological activity of IL-1α with a high degree of affinity and specificity. IL-1⍺ is a key mediator of inflammatory responses and is implicated in the pathophysiology of various diseases, including cancer, cardiovascular and rheumatologic diseases. Ample evidence supports targeting IL-1⍺ to block pathological inflammatory processes associated with many diseases.
Study NCT04825288 — intervention group
Intervention type: BIOLOGICAL
Group type: PLACEBO_COMPARATOR
Intervention: XB2001 or Placebo
Description: XB2001 is a True Human monoclonal antibody that blocks the biological activity of IL-1α with a high degree of affinity and specificity. IL-1⍺ is a key mediator of inflammatory responses and is implicated in the pathophysiology of various diseases, including cancer, cardiovascular and rheumatologic diseases. Ample evidence supports targeting IL-1⍺ to block pathological inflammatory processes associated with many diseases.
Study NCT05377307 — intervention group
Intervention type: GENETIC
Intervention: Pell's lentiviral-based gene-edited immune cell therapy
Description: No study drug or other planned treatment will be administered. Subjects who previously received Pell's lentiviral-based gene-edited immune cell therapy will be evaluated the safety and efficacy.
Study NCT05435742 — intervention group
Intervention type: BIOLOGICAL
Group type: PLACEBO_COMPARATOR
Intervention: SON-080
Description: Recombinant human interleukin-6 (rhIL-6)
Study NCT05435742 — intervention group
Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: SON-080
Description: Recombinant human interleukin-6 (rhIL-6)
Study NCT04732481 — intervention group
Intervention type: PROCEDURE
Intervention: passive leg lift test
Description: passive leg lift test
Study NCT05384691 — intervention group
Intervention type: DRUG
Group type: OTHER
Intervention: Luspatercept Injection
Description: All formally included patients will receive 1.75 mg/kg luspatercept administered subcutaneously every three weeks (on day 1 of each 21-day cycle) for a duration of 24 weeks.~Responders at the response assessment (according to HI-E) in week 25 will be further treated with 1.75 mg/kg luspatercept until loss of response for an expected maximum of 18 months.
Study NCT05561530 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ALG-125755
Description: single or multiple doses of ALG-125755
Study NCT05561530 — intervention group
Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: single or multiple doses of placebo
Study NCT06429423 — intervention group
Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Acute exercise low intensity
Description: A 15-minute exercise on low intensity on a cycle ergometer. Immediately before, immediately after and 30 minutes after exercise participants will fill out questionnaires regarding feelings of fatigue, energy, anxiety and stress and measure saliva cortisol. Three times during the exercise, they will rate level of exertion (RPE) and feelings of distress on a VAS-scale.~During the 24 hours following the exercise bout they will wear a heart rate strap and an accelerometer measuring heart rate variability and activity level. Twice during that time, once in the evening, and once in the morning after, participants will answer questionnaires regarding mood state.
Study NCT06429423 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Acute exercise low intensity
Description: A 15-minute exercise on low intensity on a cycle ergometer. Immediately before, immediately after and 30 minutes after exercise participants will fill out questionnaires regarding feelings of fatigue, energy, anxiety and stress and measure saliva cortisol. Three times during the exercise, they will rate level of exertion (RPE) and feelings of distress on a VAS-scale.~During the 24 hours following the exercise bout they will wear a heart rate strap and an accelerometer measuring heart rate variability and activity level. Twice during that time, once in the evening, and once in the morning after, participants will answer questionnaires regarding mood state.
Study NCT06429423 — intervention group
Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Acute exercise moderate intensity
Description: A 15-minute exercise on moderate intensity on a cycle ergometer. Immediately before, immediately after and 30 minutes after exercise participants will fill out questionnaires regarding feelings of fatigue, energy, anxiety and stress and measure saliva cortisol. Three times during the exercise, they will rate level of exertion (RPE) and feelings of distress on a VAS-scale.~During the 24 hours following the exercise bout they will wear a heart rate strap and an accelerometer measuring heart rate variability and activity level. Twice during that time, once in the evening, and once in the morning after, participants will answer questionnaires regarding mood state.
Study NCT06429423 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Acute exercise moderate intensity
Description: A 15-minute exercise on moderate intensity on a cycle ergometer. Immediately before, immediately after and 30 minutes after exercise participants will fill out questionnaires regarding feelings of fatigue, energy, anxiety and stress and measure saliva cortisol. Three times during the exercise, they will rate level of exertion (RPE) and feelings of distress on a VAS-scale.~During the 24 hours following the exercise bout they will wear a heart rate strap and an accelerometer measuring heart rate variability and activity level. Twice during that time, once in the evening, and once in the morning after, participants will answer questionnaires regarding mood state.
Study NCT05010083 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: diet and lifestyle program
Description: See description of main arm.
Study NCT06423638 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Virtual Tai Chi Easy
Description: The TCE intervention will be delivered asynchronously online. Participants can complete the classes at a time and in a location that is convenient for them. The classes will be offered for one hour twice weekly and were developed and recorded by a certified Tai Chi Easy practice leader.~TCE is a simple form of mind-body self-care that focuses on four components:~* Mindful movements that help to stretch, and relax the body while improving balance and coordination~* Breathing practices that reduce stress by inducing a relaxation response while improving energy and circulation and enhancing innate healing responses~* Self-applied massage to stimulate blood flow, relax the body, and improve circulation and energy~* Meditation practices to relax the body, center the mind, and calm the emotions
Study NCT04493320 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Carbidopa/levodopa
Description: 150-450mg carbidopa/levodopa 3 times daily
Study NCT04493320 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo
Description: Carbidopa/levodopa-matched placebo tablet 3 times daily
Study NCT05495880 — intervention group
Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Laryngoscopy with forearm-support
Description: forearm-supported head extension during direct laryngoscopy
Study NCT05495880 — intervention group
Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Laryngoscopy without forearm-support
Description: without forearm-support for head extension during direct laryngoscopy
Study NCT04778748 — intervention group
Intervention type: DIAGNOSTIC_TEST
Intervention: Under-mattress sleep monitor
Description: Under-mattress sleep monitor for patients with a confirmed diagnosis of Obstructive Sleep Apnea.
Study NCT04739111 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Human Anti-PD-L1 Monoclonal Antibody Injection (LDP) Combined with Recombinant Anti-EGFR Human Mouse Chimeric Monoclonal Antibody Injection (CDP1)
Description: In the dose-escalation phase, CDP1 400 mg/ m2 will be given in the first week, then 250 mg/m2 will be given evert week. LDP will be given every two weeks with dose climbing of 5 mg/kg, 10 mg/kg, 20 mg/kg. Dose in the dose-expansion phase according to the assesment in the dose-escalation phase.
Study NCT06351839 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Sleep-Well despite persistent pain
Description: The Sleep-Well program covers four overarching topics stretched over 7 group sessions (each lasting \~1.5 hours): 1) providing information about sleep physiology, causes of sleep problems, sleep habits and hygiene and use of sleep assessment methods (i.e., sleep diaries) for deciding sleep restriction schedules; 2) behavioural strategies through the application of stimulus control and sleep restriction; , 3) mental strategies by addressing and changing unhelpful (meta)cognitions that commonly occur in sleep and persistent pain conditions; and 4) strategies related to maintenance of good sleep and prevention of relapse. The program has been developed by Diakonhjemmet hospital in Oslo and includes a guideline for therapist and a workbook for patients (that includes home tasks for the participant).
Study NCT06351839 — intervention group
Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: TAU (treatment-as-usual)
Description: The treatment-as-usual arm represents an active waiting-list arm as subjects receive standard care, which may involve some sleep assessment, rudimentary advice/education about sleep, and possibly also sleep medication. The type of sleep treatment this group receives during the waiting-list period will be recorded from the patients' journal.
Study NCT04708262 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Cognitive Analytic Therapy for Containing Self-Harm in Young People
Description: The intervention will run over five sessions, each lasting around 30 - 40 minutes. Researchers will follow the CATCH-Y manualised treatment guide. CATCH-Y is a brief, five session psychological intervention based upon CAT principles and designed to help young people who have self-injured.
Study NCT05217459 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Self-expanding intracranial drug stent system
Description: All patients receive Percutaneous transluminal angioplasty and stenting with self-expanding intracranial drug stent system (Temporary abbreviations: SINOMED IS-DES)
Study NCT05816746 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Low-Dose Decitabine plus anti-PD-1
Description: Decitabine 10mg/d，VD d1-5; PD-1 200mg，d8
Study NCT04799353 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Budigalimab
Description: Subcutaneous (SC)
Study NCT04799353 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo
Description: Subcutaneous (SC)
Study NCT05871619 — intervention group
Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Remin Pro
Description: A photosensitizing-remineralizing agent mixture was prepared by adding pre-green dye The diode laser was irradiated immediately with 1 W, Exposure time of 10 s, 810 nm, continuous and non-contact mode.
Study NCT05871619 — intervention group
Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: X Pur Remin
Description: A photosensitizing-remineralizing agent mixture was prepared by adding pre-green dye The diode laser was irradiated immediately with 1 W, Exposure time of 10 s, 810 nm, continuous and non-contact mode.
Study NCT05871619 — intervention group
Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Fluoride varnish
Description: A photosensitizing-remineralizing agent mixture was prepared by adding pre-green dye The diode laser was irradiated immediately with 1 W, Exposure time of 10 s, 810 nm, continuous and non-contact mode.
Study NCT06304025 — intervention group
Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Wharton's jelly mesenchymal stem cells (WJ-MSCs)
Description: Four doses of 1x10 6 of thawed allogeneic WJ-MSCs or expanding allogeneic WJ-MSCs / kg at 1, 4, 11, and 18 days
Study NCT05017974 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Mindfulness-Based Stress Reduction plus Prenatal Sleep supplement
Description: MBSR+PS
Study NCT05017974 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Treatment as Usual
Description: TAU
Study NCT05017974 — intervention group
Intervention type: OTHER
Group type: OTHER
Intervention: Treatment as Usual
Description: TAU
Study NCT06493149 — intervention group
Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Massage therapy
Description: Participants receive a Swedish massage based on the tensegrity principle.
Study NCT06493149 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Massage therapy
Description: Participants receive a Swedish massage based on the tensegrity principle.
Study NCT04401423 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: TXA127
Description: 0.5 mg/kg per day
Study NCT04722159 — intervention group
Intervention type: DEVICE
Intervention: Renal denervation
Description: Catheter-based inhibition of renal sympathetic nerve traffic.
Study NCT04731870 — intervention group
Intervention type: OTHER
Intervention: Survey research
Description: This is not an intervention study. It involves social science research of surveys and focus groups.
Study NCT04401423 — intervention group
Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: 0.5 mg/kg per day
Study NCT06359392 — intervention group
Intervention type: OTHER
Group type: OTHER
Intervention: No message
Description: Participants will not be exposed to a message in this arm of the intervention.
Study NCT06359392 — intervention group
Intervention type: OTHER
Group type: OTHER
Intervention: Culture-centric message
Description: Participants in this arm of the study will watch a 2-minute video on palliative care developed specifically for these American Indian communities.
Study NCT06359392 — intervention group
Intervention type: OTHER
Group type: OTHER
Intervention: General messge
Description: Participants receiving this intervention will watch a 2-minute video developed by the National Hospice and Palliative Care Organization to teach about palliative care.
Study NCT04799353 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Budigalimab
Description: Intravenous (IV)
Study NCT04799353 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo
Description: Intravenous (IV)
Study NCT06299852 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Trastuzumab emtansine
Description: SRT for metastatic foci
Study NCT05808153 — intervention group
Intervention type: RADIATION
Group type: ACTIVE_COMPARATOR
Intervention: radiotracer injection
Description: MRI with radiotracer injection
Study NCT05808153 — intervention group
Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: radiotracer injection
Description: MRI with radiotracer injection
Study NCT05987462 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Green walking
Description: The researcher provided detailed information to the patients about green walking. For the randomized MI patients, two groups were formed, and they engaged in a 50-minute green walking three days a week for 12 weeks, under the guidance of the researcher. The green walk group's walks were scheduled differently for the two subgroups. The first subgroup had their 50-minute walk on Monday, Wednesday, and Saturday, while the second subgroup had their walks on Tuesday, Thursday, and Sunday. This arrangement ensured a standardized time interval between green walks for both groups.
Study NCT05134610 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: AEROBIKA POSITIVE EXPIRATORY PRESSURE DEVICE
Description: Intervention arm patients use the OPEP device twice daily for 2 weeks before and after surgery
Study NCT05386342 — intervention group
Intervention type: DEVICE
Group type: OTHER
Intervention: TufTex Over-the-Wire Embolectomy Catheter
Description: The OTW Catheter can be used for the removal of emboli and thrombi. It can also be used for catheter placement over a guidewire, vessel occlusion, fluid infusion and/or aspiration.
Study NCT05578989 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Virtual reality glasses
Description: watching a video with music with virtual reality glasses.
Study NCT04457128 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Just-in-Time Adaptive Intervention
Description: Randomized factorial design
Study NCT05262413 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: QL1706 Plus Lenvatinib
Description: QL1706 5mg/kg administered intravenously (IV), every 3 weeks, plus Lenvatinib 20 mg or 14mg administered orally, once daily.
Study NCT04963816 — intervention group
Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: ultrasound guided quadratus lumborum block
Description: Ultrasound guided quadratus lumborum block will be done to all groups using curved array transducer 5_2 MHz with the patient in supine position and the block will be done by anterior approach
Study NCT04963816 — intervention group
Intervention type: PROCEDURE
Group type: PLACEBO_COMPARATOR
Intervention: ultrasound guided quadratus lumborum block
Description: Ultrasound guided quadratus lumborum block will be done to all groups using curved array transducer 5_2 MHz with the patient in supine position and the block will be done by anterior approach
Study NCT04963816 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Dexamethasone Phosphate 4 MG/ML Injectable Solution intravenously
Description: Using dexamethasone as an adjuvant to bupivacaine in ultrasound guided quadratus lumborum block which will be given intravenously in group A
Study NCT04963816 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Bupivacaine Injection
Description: Bupivacaine will be given to all groups locally with QLB
Study NCT04963816 — intervention group
Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Bupivacaine Injection
Description: Bupivacaine will be given to all groups locally with QLB
Study NCT04963816 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Dexamethasone Phosphate 4 MG/ML Injectable Solution locally
Description: Using dexamethasone as an adjuvant to bupivacaine in ultrasound guided quadratus lumborum block which will be given locally in Group B
Study NCT04782349 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: mulligan mobilization with low level laser therapy and traditional physical therapy exercises
Description: for mulligan mobilization: for improving the limited range of motion of shoulder joint, the therapist will apply posterolateral mobilization for the shoulder joint. Three sets of painless glides of 10 repetitions will be applied with a rest interval of 30 s between each set.~For low level laser application: Laser specifications is as follows: 850 nm wave length and pulsed application with 8 W applied for 20 minutes. laser will be applied over painful points of the shoulder.~For traditional physical therapy exercises: the patients will receive the following exercise program: self stretching exercises for shoulder joint, pully exercises, back climbing exercises, finger ladder exercises, circumduction exercises and pendulum exercises
Study NCT04782349 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: low level laser therapy and traditional physical therapy exercises
Description: patients in this group will receive low level laser and traditional physical exercises as described before for group (A)
Study NCT04224792 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Center-based exercise program
Description: A routine individualized exercise prescription and supervised exercise sessions at a minimum of once per week for 11 weeks with an exercise prescription updated monthly.
Study NCT04224792 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Home-based exercise program
Description: A one-time supervised exercise session with Cardiac Rehabilitation staff and a routine individualized exercise prescription for exercises to do at home. Additionally, weekly telephone followup calls by a clinical exercise physiologist for 11 weeks consisting of an exercise tip.
Study NCT05710965 — intervention group
Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: FRx-001
Description: Wearable digital therapy
Study NCT05710965 — intervention group
Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: FRx-003
Description: Wearable digital therapy
Study NCT05710965 — intervention group
Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: FRx-004
Description: Wearable digital therapy
Study NCT04904003 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Rehabilitation Intervention
Description: Strength, flexibility, endurance, balance, mobility, (self-efficacy)
Study NCT04782349 — intervention group
Intervention type: OTHER
Group type: OTHER
Intervention: physical therapy exercises
Description: The patients will receive traditional physical therapy exercises only as described before for group (A)
Study NCT06056180 — intervention group
Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Balance Training
Description: Participants will be given static and dynamic balance training with a balance platform game console (20 minutes) containing interactive video games based virtual reality for a total of 6 weeks.
Study NCT06056180 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Balance Training
Description: Participants will be given static and dynamic balance training with a balance platform game console (20 minutes) containing interactive video games based virtual reality for a total of 6 weeks.
Study NCT06056180 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Motor İmagery Training
Description: For motor imagery training, two visualization scenarios will be created: anterior and posterior motor imagery. One of the visualization scenarios appropriate to each individual's needs will be used. Participants will be asked to perform kinesthetic or visual motor imagery in accordance with the scenario they listened to (10 minutes).
Study NCT06056180 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Action Observation Training
Description: Action observation training will be done using video modeling method. The video content will include Nintendo Wii games in which the games that the person will play in that session are played by someone else and successful scores are achieved (10 minutes).