AIM-Harvard/TrialPanorama-filtered huggingface dataset:
Study NCT05519072 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Nitrofurantoin
Description: For those randomized to the treatment arm, antibiotics will be prescribed at the discretion of the ordering physician. They will be prescribed only in oral form and in accordance with the patient's allergy profile.
Study NCT03919344 — intervention group
Intervention type: OTHER
Group type: OTHER
Intervention: Critical airway closure pressure (Pcrit) measurment
Description: Pcrit is measured in awake patient, by applying a gradually decreasing pressure through a nasal NIV mask. Pcrit is defined as the pressure inducing airflow cessation in upper airway
Study NCT04888637 — intervention group
Intervention type: DIAGNOSTIC_TEST
Intervention: Baseline MEG Test
Description: Each subject will have one MEG session with the recordings of baseline resting state, language and memory protocols. Subjects will have a break period between the language and memory tasks. MEG recordings will be acquired for approximately 35 minutes. The subject will be allowed to practice the language and memory tasks before the MEG recording to feel familiar with them. This practice phase will be a short version of the task administered by a computer and will take approximately 6 minutes.
Study NCT04888637 — intervention group
Intervention type: BEHAVIORAL
Intervention: Receptive Language Task
Description: The subject will perform a practice session where they will be instructed to try to remember a set of ﬁve audibly spoken English words, deemed targets (jump, little, please, drink, and good). Depending on the subject's overall verbal memory capacity, the target words will be presented once or twice during the practice phase. Subsequently, during the MEG recording, the ﬁve target words will repeat in a different random order, mixed with a different set of 40 distractors (non-repeating words) in each of three blocks of stimuli. The subject's task will be to listen to the words and lift their index finger of the dominant hand whenever they hear a repeated target word (one of the five). After the language task, the subject will be given a break.
Study NCT04888637 — intervention group
Intervention type: BEHAVIORAL
Intervention: Memory Task
Description: The subject will be tasked with indicating whether the encoding stimulus matched the retrieval stimulus using two buttons; one for congruent and the other for incongruent response. Button type will be counterbalanced among subjects. The task will take around 16 minutes. The visual stimuli will be projected through an LCD projector onto a white screen located about 0.5 m in front of the subject and subtending 1.0-4.0 and 0.5 degrees of horizontal and vertical visual angle, respectively. A MEG compatible keyboard will be used to measure the subject's responses for congruent and incongruent. The subject will practice the memory task before going to the MEG system using a computer from MEG laboratory. This practice phase will consist of a short version of the memory task with duration of approximately 4 minutes.
Study NCT05267314 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: pharyngeal exerciser + standard therapy
Description: Use of Pharyngeal exerciser
Study NCT05363137 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Chatbot Assistant
Description: The physiotherpy treatment will be supervised via chatbot
Study NCT05363137 — intervention group
Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Standard care
Description: The physiotherpy treatment will be standard care
Study NCT06171906 — intervention group
Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: mesenchymal stromal cells
Description: On the basis of conventional PGF treatment for poor implantation, the enrolled patients were injected with 1×10\^6/kg mesenchymal stem cells of cord blood weekly for 4 consecutive weeks
Study NCT04866511 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Narrative Exposure Therapy
Description: NET is a trauma-focused psychological treatment for people who experienced multiple traumas (Schaeur et al., 2011).~An adaptation named KIDNET was developed for use with children and young people (Neuner et al., 2008; Schauer et al., 2011, 2017).~Participants will be offered 6-10 weekly sessions of NET lasting approximately 90 minutes each. The sessions will be delivered by a Trainee Clinical Psychologist via videoconferencing, in line with the UK's Government guidelines around reducing face-to-face contacts during the Covid-19 pandemic.
Study NCT05723848 — intervention group
Intervention type: DEVICE
Intervention: Smartwatch (Withings Scanwatch)
Description: All-day monitoring of patients via smartwatch
Study NCT05468775 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Naked eye 3D vision training
Description: 20 minutes of naked eye 3D vision training every day
Study NCT04466410 — intervention group
Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: XT-150
Description: Single bolus intrathecal injection
Study NCT04466410 — intervention group
Intervention type: BIOLOGICAL
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Placebo is a sterile phosphate-buffered saline
Study NCT05630378 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: outpatient clinic with multimodal integrative medicine and naturopathy for post-COVID-19 patients
Description: Patients receive multimodal integrative medicine and naturopathy applications with focus on mind-body-medicine and whole body hyperthermia to reduce fatigue and improve quality of life.
Study NCT05630378 — intervention group
Intervention type: OTHER
Group type: OTHER
Intervention: waiting group
Description: Patients receive no intervention
Study NCT05337488 — intervention group
Intervention type: OTHER
Intervention: questionnaire with interview
Description: They will be invited to complete a questionnaire and an individual semi-structured interviews.
Study NCT05940831 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Support-Moms
Description: Scheduled SMS-audio messages from the final messaging prototype (SM), plus social supporter engagement through SMS (SS).
Study NCT05940831 — intervention group
Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Control
Description: Routine care/ information giving
Study NCT04584502 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Mindful Moms Yoga Mindfulness Intervention
Description: MMORE is an 8-session yoga-mindfulness intervention protocol, offered via Zoom over the course of 10 consecutive weeks at the partner maternity care practice or a nearby location. Each session will last approximately 60 minutes (8 - 10 participants per group). Intervention participants will also be asked to use a mobile companion app at least once each week of the intervention period.
Study NCT06276517 — intervention group
Intervention type: OTHER
Intervention: questionnaire
Description: self-questionnaire with 16 questions, rated from 0 to 4, giving a total of 0 to 52 points.
Study NCT06276517 — intervention group
Intervention type: OTHER
Intervention: SS-QoL
Description: 49-question self-administered questionnaire covering 12 domains (including work/productivity, mood, social roles, family roles, personality, etc.).
Study NCT06276517 — intervention group
Intervention type: OTHER
Intervention: SF-36
Description: multidimensional, generic scale, i.e. one that assesses health status independently of causal pathology, sex, age and treatment
Study NCT06276517 — intervention group
Intervention type: OTHER
Intervention: CIQ-R
Description: 16-question questionnaire with answers rated from 0 to 2 to assess Social reintegration
Study NCT06276517 — intervention group
Intervention type: DIAGNOSTIC_TEST
Intervention: BREFF
Description: rapid frontal efficiency battery, 6 tests from 0 to 3 on each side
Study NCT06276517 — intervention group
Intervention type: DIAGNOSTIC_TEST
Intervention: MoCA
Description: MoCA is a screening test for neurocognitive impairment. It comprises 11 categories scored from 0 to 6 for a total of 0 to 30 points.
Study NCT06276517 — intervention group
Intervention type: OTHER
Intervention: IADL
Description: 8 questions rated from 0 to 1 to assess functional outcome
Study NCT06276517 — intervention group
Intervention type: OTHER
Intervention: mMRS
Description: mMRS score from 0 to 4 to assess functional outcome
Study NCT06276517 — intervention group
Intervention type: OTHER
Intervention: PCL-5
Description: To assess the prevalence of post-traumatic stress using the PCL-5 self-questionnaire. PCL-5 is a 20-item self-administered questionnaire.
Study NCT06276517 — intervention group
Intervention type: OTHER
Intervention: Brief-Cope
Description: 28-question self-questionnaires to study patients' coping strategies
Study NCT03919344 — intervention group
Intervention type: OTHER
Group type: OTHER
Intervention: Acoustic pharyngometry
Description: Acoustic pharyngometry will assess the volume of the pharynx and determine if there is an obstacle in the upper airways.
Study NCT03919344 — intervention group
Intervention type: OTHER
Group type: OTHER
Intervention: High density surface electroencephalogram neural mapping
Description: Mapping of the respiratory neural network will allow us to study the areas of the brain activated during breathing
Study NCT05857332 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: SG1906
Description: Phase 1a will use an accelerated titration-Bayesian optimal interval (AT-BOIN) design with 7 dose cohorts: 0.1 mg/kg, 0.3 mg/kg, 1 mg/kg, 3 mg/kg, 6 mg/kg, 9 mg/kg, and 12 mg/kg by IV infusion. Accelerated titration (i.e., 1 patient each) will be applied to the first 2 cohorts.
Study NCT04764383 — intervention group
Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: L-Histidine
Description: 1000 mg capsules taken by mouth (PO) twice daily (BID).
Study NCT05850182 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Lifestyle intervention
Description: 12-week lifestyle intervention including adherence to a personalized balanced dietary regimen (low total fat, low saturated fat, high ω3 fatty acids, optimized protein content, low simple sugars) combined with regular physical activity (including physiotherapy sessions and self-training).
Study NCT05781009 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Pregnenolone
Description: 300mg
Study NCT05781009 — intervention group
Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: placebo
Study NCT05226039 — intervention group
Intervention type: BEHAVIORAL
Group type: OTHER
Intervention: Moderate intensity acute exercise bout
Description: The treatment/intervention will consist of 20 minutes of moderate intensity aerobic exercise on a stationary bike. Intensity will be prescribed based off of heart rate reserve.
Study NCT05087836 — intervention group
Intervention type: DEVICE
Intervention: Sensor at forehead area
Description: NIRS sensor attached at forehead area.
Study NCT05087836 — intervention group
Intervention type: DEVICE
Intervention: Sensor at temporal area
Description: NIRS sensor attached at temporal area.
Study NCT04302051 — intervention group
Intervention type: DIAGNOSTIC_TEST
Intervention: Thermo-acuostic image acquisition of liver
Description: Estimation of hepatic fat content with thermo-acoustic device
Study NCT04302051 — intervention group
Intervention type: DIAGNOSTIC_TEST
Intervention: MRI-PDFF estimation of hepatic fat
Description: Estimation of hepatic fat content with MRI
Study NCT05624489 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Engagement Strategies
Description: The study's mobile app (Oralytics) will be used to deliver engagement prompts. The prompts contain messages that leverage three engagement strategies: reciprocity, reciprocity by proxy, and curiosity.
Study NCT06480331 — intervention group
Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Ultrasound-guided fistuloplasty
Description: Radiation free fistuloplasty
Study NCT06480331 — intervention group
Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Fluoroscopy-guided fistuloplasty
Description: Conventional fistuloplasty
Study NCT05264142 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Voriconazole 200mg
Description: Voriconazole is a weak CYP2C19 inhibitor. It is used in study session 2 to study the impact of a weak inhibitor on the phenotype switch among the different genotypes included in the study.
Study NCT05264142 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: FluvoxaMINE 50 Mg Oral Tablet
Description: Fluvoxamine is a strong CYP2C19 inhibitor. It is used in study session 3 to study the impact of a strong inhibitor on the phenotype switch among the different genotypes included in the study.
Study NCT05264142 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Omeprazole 10 MG Oral Tablet
Description: Omeprazole is a CYP2C19 probe substrate. It is used in the study as a tool for CYP2C19 phenotyping at each of the sessions.
Study NCT05982080 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: FP002 Injection
Description: Up to 6 FP002 dose levels (0.3, 1.0, 3.0, 10, 20, 30 mg/kg administered intravenously may be evaluated. Subjects will receive weekly infusions of FP002 until disease progression, unacceptable toxicity, consent withdrawal, physician decision, or start of subsequent anticancer therapy, whichever occurs first.
Study NCT05771597 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Home Biofeedback therapy
Description: Patients will be given home biofeedback device to take home and practice biofeedback exercises at least twice a day for six weeks of therapy.~1. HBT for patients with constipation and dyssynergic defecation:~   Patients will attend one session of training on how to use the device followed by daily sessions at home for 6 weeks. After placing a probe into rectum, the patient sits on a commode, activates the smart phone app and follow the voice-guided instructions to perform diaphragmatic breathing exercises and push maneuvers with/without balloon distension.~2. HBT for patients with FI:~   Subject will receive training on how to use the home-trainer device and probe placement. The patient will be asked to follow a series of voice guided instructions consisting of performing short and long duration squeeze maneuvers over 25 minutes.~3. HBT for patients with UI:~The instructions protocol as written above for patients with FI will be followed for UI patients as well.
Study NCT05771597 — intervention group
Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Office biofeedback therapy
Description: Patients will receive traditional office biofeedback, once weekly, over six weeks.~1. OBT for patients with constipation and dyssynergic defecation:~   The patient will receive instructions on the diaphragmatic breathing techniques. Then the patient sits on a commode, coordination between push effort and the anal and pelvic floor relaxation is corrected by the therapist. The patients will receive visual and verbal feedback instructions from the therapist.~2. OBT for patients with FI:~   Patients will be taught Kegels and abdominal muscle exercises. Visual and verbal feedback techniques are used to reinforce the maneuvers. The patient is instructed to squeeze and to maintain this squeeze for as long as possible.~3. OBT for patients with UI:~Biofeedback training is performed using the protocol and objectives as described above for FI training.
Study NCT04899401 — intervention group
Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Standard of care + PediaFlù®
Description: Standard of care: Standard of care for acute tonsillitis / rhinopharyngitis is focused on symptomatic treatment. PediaFlù®: During the 6 days of the clinical investigation, the subjects will administer PediaFlù® 5ml x3 times per day for children below 6 years and 10mlx3 times per day for children above 6 years.
Study NCT04899401 — intervention group
Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Standard of care
Description: Standard of care for acute tonsillitis / rhinopharyngitis is focused on symptomatic treatment. Standard of care Nasopharyngeal liberation through hydration with drinking fluids to support body fluid excretion, aspiration of secretions, NaCl solution for nasal irrigation, Nasal sprays with sea water, nasal spray with active compound (to be used only at special indication of the medical doctor) Throat spray with Benzydamine hydrochloride (Tantum Verde®), Pediatric use: children over 6 and below 12: 4 sprays 2 - 6 times a day. Children (under 6 years): 1 spray per 4 kg of body weight, a maximum of 4 sprays at once, 2-6 times a day according to the leaflet. Each spray equals 0.17 ml of solution. Acetaminophen (Paracetamol) per os: at need, as antipyretic (>38,5C), 10 mg/kg/dose, per need every 6-8 hours or according to the leaflet, maximum dosage 80 mg / kg / day. A dosage of over 30 mg/Kg/dose will result in an IP failure;
Study NCT04764383 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: L-Histidine
Description: 1000 mg capsules taken by mouth (PO) twice daily (BID).
Study NCT04764383 — intervention group
Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Microcrystalline cellulose (placebo) 1000 mg capsules taken by mouth (PO) twice daily (BID).
Study NCT04764383 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo
Description: Microcrystalline cellulose (placebo) 1000 mg capsules taken by mouth (PO) twice daily (BID).
Study NCT04764383 — intervention group
Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Lodosyn
Description: 50 mg capsules taken PO BID.
Study NCT04764383 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Lodosyn
Description: 50 mg capsules taken PO BID.
Study NCT06460337 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Modified Otago exercises
Description: Participants will engage in modified Otago exercise sessions, either individually or in groups, for 45 minutes, thrice weekly over an 8-week period. The program entails moderate-intensity strengthening exercises targeting various muscle groups such as hip extensors, abductors, knee flexors and extensors, inner range quadriceps, ankle plantar flexors, and dorsiflexors, performed at 10 repetitions maximum (RM) with ankle cuff weights ranging from 0.5 to 1 kg. Additionally, balance exercises will be conducted, initially with support and gradually progressing to without support, including knee bends, backwards walking, sideways walking, tandem stance and walk, one leg stance, heel and toe walking, sit-to-stand, stair climbing, stepping over objects, and bending to pick up objects from the floor. Participants are also encouraged to walk outdoors at their usual pace for 30 minutes at least three times weekly.
Study NCT06460337 — intervention group
Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Frenkel's exercises
Description: Frenkel's exercise regimen comprises a series of movements performed in lying, sitting, stride standing, and standing positions aimed at improving coordination and motor control. In the lying position, exercises include alternating hip and knee flexion/extensions, hip abduction/adduction, pedaling the lower limbs, and simultaneous movements of hips and knees. These are executed slowly to enhance coordination. In sitting, exercises involve leg stretching, hip flexion with knees flexed or straightened, and transitions from sitting to standing and back. Stride standing exercises focus on weight transfer and sideways walking, while standing exercises encompass walking on marked paths, trunk rotations, 360-degree turns, smaller arcs of hip abduction/adduction and flexion/extension, straight-line walking, and directional changes to simulate real-life obstacles. 3 sets comprising 10 repetitions are performed for each exercise, aiming for motor skill improvement and balance enhancement
Study NCT04724096 — intervention group
Intervention type: DIAGNOSTIC_TEST
Intervention: Oxygen Enhanced MRI scan
Description: Dynamic MRI scanning switching from breathing room air to high concentration oxygen part way through the scan.
Study NCT05817474 — intervention group
Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: lidocaine (2 %) 2 ml and tranexamic acid
Description: lidocaine (2 %) 2 ml and tranexamic acid 2 ml in each tonsillar bed
Study NCT05817474 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: lidocaine (2 %) 2 ml and tranexamic acid
Description: lidocaine (2 %) 2 ml and tranexamic acid 2 ml in each tonsillar bed
Study NCT05248698 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: lifestyle change
Description: 30 older patient who will complain from dry eye will receive 3-time interval exercise per the week, applied for 30 min with high intensity, plus Mediterranean Diet for 6 months
Study NCT05248698 — intervention group
Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: exercise
Description: 30 older patient who will complain from dry eye will receive 3-time interval exercise per the week, applied for 30 min with high intensity, for 6 months
Study NCT05038709 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: The Pink Pad Hip Kit
Description: The pad is placed between the patient and the traction table to reduce pressure to the pudendal nerve exerted by the perineal post.
Study NCT06410339 — intervention group
Intervention type: DIAGNOSTIC_TEST
Intervention: Ultrasound
Description: ultrasound of flexor tendons on hands
Study NCT06338436 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Proton Radiation Therapy System (ProBeam)
Description: All enrolled subjects will be treated with Proton radiation therapy using the medical device Varian Proton Therapy System (ProBeam). The screening period from informed consent to enrollment is expected to be 2 weeks, while the treatment period depends on patient medical situation and treatment plan. The period after the last treatment is divided into short-term follow-up which is 90 days after treatment completion and long-term follow-up which is 5 years after treatment completion. The clinical trial with short-term follow-up fulfills the requirements for NMPA regulatory registration. All the end points claimed will be achieved in the short-term follow-up stage. The trial is defined as completion once short-term follow-up is finished.
Study NCT05186896 — intervention group
Intervention type: OTHER
Intervention: Risk perception questionnaire
Description: A questionnaire for risk perception will be developed and administered
Study NCT05651113 — intervention group
Intervention type: OTHER
Intervention: SCID Screening
Description: The addition of newborn bloodspot screening for severe combined immunodeficiency
Study NCT04698798 — intervention group
Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Muscle Biopsy
Description: Patients will be treated for SARS-CoV-2 symptoms on the intensive care unit. During this treatment two muscle biopsies will be obtained with an interval of seven days between them.
Study NCT05219097 — intervention group
Intervention type: DIAGNOSTIC_TEST
Intervention: CBA Assay
Description: Comparsion of specificity, sensitivity and clinical correlation of CBA, ELISA and RIPA assay in autoantibodies detection of myasthenia gravis