AIM-Harvard/TrialPanorama-filtered huggingface dataset:
Study NCT05750693 — intervention group
Intervention type: GENETIC
Group type: EXPERIMENTAL
Intervention: PIK3CA analysis
Description: PIK3CA will be investigated together with HER2 in pre-NAD tissue samples, in order to evaluate the correlation with response to NAD chemotherapy, with a 16-gene MYRIAPOD kit. This evaluation will be performed on all 58 patients in the study for group (responders and not responders).~Moreover 10 patient samples (5 responders and 5 non-responders) will be subjected to gene expression profile analysis. Specifically, a transcriptomic analysis will be performed on total RNA from one inch of cells (10-50 cells isolated by LCM from FFPE biopsy, RNA seq) which will allow to have the transcriptional profile for each patient of protein-coding transcripts (coding RNAs) and long non-coding RNAs.~In addition, an NGS analysis by TSO500 will be performed in parallel, on the slide following the previous one, to have the genome sequence (523 genes) on the same 10-50 cells isolated by LCM from FFPE biopsy for the identification of any mutations.
Study NCT03160430 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: apabetalone
Description: RVX000222 oral (apabetalone), 100 mg capsule
Study NCT03160430 — intervention group
Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: apabetalone
Description: RVX000222 oral (apabetalone), 100 mg capsule
Study NCT03160430 — intervention group
Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebos
Description: matching placebo capsule
Study NCT06113042 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Health talks, learning packs
Description: All participants can join the health talks and receive the learning packs.
Study NCT06113042 — intervention group
Intervention type: BEHAVIORAL
Group type: PLACEBO_COMPARATOR
Intervention: Health talks, learning packs
Description: All participants can join the health talks and receive the learning packs.
Study NCT06113042 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Lifestyle modification programme
Description: In Group 1: The programme includes both knowledge and activity/practicum sessions for children and parents. It will be carried out in district community hubs.~Group 2: The programme focuses on the knowledge sessions for parents. It will be carried out in schools.~Group 3: The programme focuses on the activity/practicum sessions for children and parents. It will be carried out in district community hubs.
Study NCT06113042 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: School healthy environment evaluation
Description: Evaluation on school healthy environment will be carried out in Group 1 and Group 2 to enhance the schools to provide a healthy school environment to children.
Study NCT05294263 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Varenicline
Description: Varenicline is a selective nACHr partial agonist of the 4 2 subtype and a full agonist of the 7 subtype
Study NCT05294263 — intervention group
Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Matching, inactive medication
Study NCT06026566 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Dos of Afentanil 20
Description: the dosage of Afentanil is 20 ng/ml for TCI
Study NCT06026566 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Dos of Afentanil 30
Description: the dosage of Afentanil is 30 ng/ml for TCI
Study NCT06026566 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Dos of Afentanil 40
Description: the dosage of Afentanil is 40 ng/ml for TCI
Study NCT06026566 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Dos of Afentanil 50
Description: the dosage of Afentanil is 50 ng/ml for TCI
Study NCT06026566 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Dos of Afentanil 60
Description: the dosage of Afentanil is 60 ng/ml for TCI
Study NCT06026566 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Dos of Afentanil 70
Description: the dosage of Afentanil is 70 ng/ml for TCI
Study NCT06026566 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Dos of Afentanil 80
Description: the dosage of Afentanil is 80 ng/ml for TCI
Study NCT06026566 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Dos of Afentanil 90
Description: the dosage of Afentanil is 90 ng/ml for TCI
Study NCT06026566 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Dos of Afentanil 100
Description: the dosage of Afentanil is 100 ng/ml for TCI
Study NCT04979221 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Cyproheptadine
Description: Cyproheptadine 8mg three times a day during 10 days
Study NCT05864027 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Peer-led Oral Health Recovery Group
Description: The interactive Oral Health Recovery group will be centered around the tailored materials previously developed, with topics such as it's never too late to make a change, oral health and whole health, taking care of your teeth, and going to the dentist.
Study NCT05864027 — intervention group
Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Educational Video about Oral Health
Description: The video comparison will be pulled from Toothflix 2.0 Patient Education DVD Series, which are patient education videos developed by the American Dental Association.
Study NCT04349852 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: BrainHQ Cognitive Training Modules
Description: The BrainHQ is a computerized training program developed from Posit Science designed to improve multiple cognitive domains. The subtests exercises include 6 modules for the experimental group: 1) Sound Sweeps: which is identify whether sound pitches are going up or down; 2) Memory Grids: matching pairs of words; 3) Syllable Stack: recognition of sequences of confusable syllables; 4) Fine Tuning: recognition of the order of confusable syllables; 5) To-Do List Training: reconstruction of sequences of verbal instructions; 6) In The Know: identification of details in a verbally presented story. Since the intervention is presented both visually and verbally through the computer, participants will be asked to complete their training in a quiet space and time to complete these activities.
Study NCT04349852 — intervention group
Intervention type: BEHAVIORAL
Group type: OTHER
Intervention: BrainHQ People Skills Modules
Description: The BrainHQ is a computerized training program developed from Posit Science designed to improve multiple cognitive domains. The BrainHQ will provide 3 training modules for the control group: 1) Recognition: a picture of a face is presented briefly and then the subject picks the recognized face from 3 pictures. 2) Face to Face: matching the emotional expression of 3 pictures to the emotional expression of the picture previously presented; 3) Face Facts: recalling 3 facts about a person that was previously presented. Participants will spend 45 minutes at each training session. Since the intervention is presented both visually and verbally through the computer, participants will be asked to complete their training in a quiet space and time to complete these activities.
Study NCT06323304 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Auricular acupressure
Description: Auricular acupressure therapy will be performed once a week for 4 weeks using Vaccaria seeds, which is an herb in traditional medicine. The acupoints on the ear that will be treated with auricular acupressure therapy are Shenmen (TF4), Internal nose (TG4), Lung (CO14), Wind stream (SF1,2i), Adrenal gland (TG2p). These acupoints are believed to be effective in the treatment of allergic rhinitis. The patches will be kept on the auricle for one week.
Study NCT06323304 — intervention group
Intervention type: OTHER
Group type: SHAM_COMPARATOR
Intervention: Sham acupressure
Description: Sham acupressure therapy will be performed once a week for 4 weeks using Vaccaria seeds. The acupoints that will be treated with auricular acupressure therapy are Helix 2 (HX10), Shoulder (SF4), Clavicle (SF6), Anus (HX5) and Tooth (LO1). These acupoints are not used to treat allergic immune-related problems or respiratory diseases. The patches will be kept on the auricle for one week.
Study NCT06323304 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Standard treatment
Description: Standard treatment, continuously administered over the 4-week intervention period, involves standard doses of fluticasone propionate nasal spray as needed, and lifestyle modifications.
Study NCT06323304 — intervention group
Intervention type: OTHER
Group type: SHAM_COMPARATOR
Intervention: Standard treatment
Description: Standard treatment, continuously administered over the 4-week intervention period, involves standard doses of fluticasone propionate nasal spray as needed, and lifestyle modifications.
Study NCT04847050 — intervention group
Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Messenger ribonucleic acid (mRNA)-1273 Vaccine
Description: A rapid response, proprietary messenger RNA (mRNA)-based vaccine platform. 100 mcg administered intramuscular (IM) on Day 1 and 29 for vaccine naive cohorts.
Study NCT06157294 — intervention group
Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Intra-articular pulsed radiofrequency
Description: Intra-articular pulsed radiofrequency procedures for the treatment of facet joint-related low back pain are performed under sterile conditions in the operating room. The application is performed under fluoroscopy guidance using a 20 gauge 10 mm active tip radiofrequency needle. When the intra-articular joint, which is the target tissue, is reached with the help of fluoroscopy images, pulse radiofrequency treatment will be applied with the parameters being maximum temperature 42 degrees, 45 volts, duration 6 minutes, pulse rate 2 hertz and pulse width 20 milliseconds.
Study NCT06157294 — intervention group
Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Median branch pulsed radiofrequency
Description: Median branch pulsed radiofrequency procedures for the treatment of facet joint-related low back pain are performed under sterile conditions in the operating room. The application is performed under fluoroscopy guidance using a 20 gauge 10 mm active tip radiofrequency needle. When the median branch region, which is the target area, is reached with the help of fluoroscopy images, location confirmation will be provided by giving sensory and motor stimulation. Pulse radiofrequency treatment will be applied with the parameters being maximum temperature 42 degrees, 45 volts, duration 6 minutes, pulse rate 2 hertz and pulse width 20 milliseconds.
Study NCT04847050 — intervention group
Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Messenger ribonucleic acid (mRNA)-1273 Vaccine Booster
Description: A rapid response, proprietary messenger RNA (mRNA)-based vaccine platform. 100 mcg administered intramuscular (IM) on Day 1 for vaccine booster cohorts. Participants may receive up to 3 booster injections on study.
Study NCT04847050 — intervention group
Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: ECG
Description: Baseline (-28 days/Day 1); and Day 29 (+/- 3 days).
Study NCT05010499 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Levobupivacaine
Description: femoral nerve block receives 20 ml of levobupivacaine 0.25%
Study NCT05010499 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Levobupivacaine
Description: Fascia iliaca block receives 40 ml of levobupivacaine 0.25%
Study NCT04847050 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Antibiotics
Description: Use of prophylactic antibiotics is recommended according to institutional standards.
Study NCT04847050 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Anti-viral agents
Description: Use of prophylactic antiviral agents is recommended according to institutional standards.
Study NCT04847050 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Anti-fungal agent
Description: Use of prophylactic antifungal agents is recommended according to institutional standards.
Study NCT04847050 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Anti-emetics
Description: Use of prophylactic anti-emetics is recommended according to institutional standards.
Study NCT05305313 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Propofol
Description: Propofol delivery will be controlled using automated closed loop anaesthesia delivery system which will control propofol delivery rate to consistent anaesthetic depth (BIS-50) feedback from the patient.
Study NCT05113277 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Tonic Immobility Psychoeducation (TIP)
Description: TIP is a 45-minute computerized psychoeducation intervention aimed at addressing maladaptive cognitions and emotions associated with TI while using educational and behavioral techniques commonly used in the treatment of trauma-related disorders. Throughout the psychoeducation program vignettes will be presented to clarify concepts and promote participant engagement. In addition, practice exercises and rating scales will be integrated, where applicable, to increase the interactive nature of the program. The following modules will be addressed in the TI psychoeducation intervention: education, myth busting, and behavioral experiments.
Study NCT05113277 — intervention group
Intervention type: BEHAVIORAL
Group type: PLACEBO_COMPARATOR
Intervention: Health Education Training (HET)
Description: The Healthy Education Training intervention was developed as a 45-minute online intervention that provides education about physical health habits that can impact mental health, such as diet, exercise, and sleep. This intervention has been used in prior clinical trials to control for effects of general education, general coping techniques, and use of technology. Participants in past clinical trials have reported that HET is engaging and beneficial. However, HET is not expected to have an effect on the main symptom outcomes of the current study (guilt, shame, PTSD symptoms).
Study NCT06567223 — intervention group
Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Vibration Therapy
Description: will receive the whole body vibration therapy. Patient will be ask to stand on the vibration plate in semi flexed knee position will 3 minute time of rest and therapy. It will be given for four weeks three days per week. Acceleration will be 18.0 meter per second square and frequency will be from 30 to 40 Hz. Intensity of the therapy will increase throughout all the sessions
Study NCT06567223 — intervention group
Intervention type: COMBINATION_PRODUCT
Group type: ACTIVE_COMPARATOR
Intervention: Rhythmic auditory stimulation therapy.
Description: will receive rhythmic auditory stimulation therapy. Rhythmic auditory stimulation will be given for 90 minutes along with 30 minutes of conventional physiotherapy. It will consist of 15 minutes of general body warming metronome rhythm which proceed towards RAS music based exercise of 60 minutes. This period also ends up with 15 minutes of relaxation exercise. Relaxing Music was provided through headphones having voice cancellation property for 15 min. The total session will be given three days per week for four weeks. Exercises such as lateral walking military march, anterior walking, one toe and one heel walking along with posterior walking through progression with the speed of the rhythm is done
Study NCT06554665 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: High-intensity interval training group
Description: HIIT sessions will include a 3-minute warm-up, a 20-minute main exercise on a recumbent stepper, and a 2-minute cool-down. The HIIT main exercise will include ten 1-minute high-intensity exercises interspersed with ten 1-minute low-intensity exercises. The high-intensity level will start at 75% of the Heart Rate Reserve (HRR) and will be increased by 5% every 4 weeks to reach 90% at 12 weeks as tolerated.
Study NCT06554665 — intervention group
Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Moderate-intensity continuous training group
Description: MICT sessions will include a 3-minute warm-up, a 20-minute main exercise on a recumbent stepper, and a 2-minute cool-down. The intensity of the MICT will start at 45% of the Heart Rate Reserve (HRR) and will be increased by 5% every 4 weeks to reach 60% at 12 weeks as tolerated.
Study NCT06554665 — intervention group
Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Stretching group
Description: Participants in the stretching group will receive 25 minutes of full-body stretching. The intensity of stretching will reach the point of feeling tightness or slight discomfort. Static stretching at each site will hold for 10-30 s and repeat 2-4 times.
Study NCT05786794 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Patient Navigation Program for Hearing Health Care
Description: Patients presenting for routine office visits will be invited to participate in the study and informed consent procedures and study enrollment will be conducted by a research assistant. Participants will then undergo baseline assessment. Following baseline measures, participants who screen positive for hearing loss will be contacted by the Patient Navigator (PN) to begin the intervention. The navigator will contact participants every 2 weeks to focus on addressing key aspects of Hearing Health Care (HHC): education, screening, diagnosis, and treatment. PNs will assist the patient to undergo a formal audiogram with the 12 months following enrollment. Each PN session will likely last between 10-30 minutes. Post-intervention data collection also administered by a trained interviewer, will occur following a diagnostic audiogram with an audiologist or at 12 months following enrollment.
Study NCT06274697 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Evaluation by magnetic sensor
Description: Evaluation by magnetic sensor on arm and leg
Study NCT05761522 — intervention group
Intervention type: OTHER
Intervention: transthoracic echocardiography
Description: * Concerning the main judgment criterion and the secondary judgment criteria:~  * Left ventricular ejection fraction (LVEF) by the Simpson Biplane method,~ * Cardiac output and cardiac index by continuity equation (measurement of left ventricular outflow chamber (mm) and sub-aortic time-velocity integral (cm/s)).~ * Tricuspid Annular Systolic Excursion (TAPSE) (mm)~ * S wave at the tricuspid ring (cm/s)~* Other parameters collected systematically:~  * Surface of the left ventricle (end-systolic and end-diastolic),~ * Global strain of the left ventricle~ * Mitral Annular Plane Systolic Excursion (MAPSE) (mm)~ * Left ventricular filling pressure (LVRP) (at the mitral annulus, E, A, e', S' waves, E/A ratio, E/e');~ * Maximum tricuspid regurgitation velocity (m/s) to estimate systolic pulmonary arterial pressure (PAPs) (mmHg)
Study NCT05702827 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Bupivacaine-Meloxicam
Description: All patients will receive standard of care but the study arm will also receive Bupivacaine-Meloxicam in addition.
Study NCT06288867 — intervention group
Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Arthroscopic Labral Repair
Description: Patients with Hip Labral tears will be treated with labral repair
Study NCT06288867 — intervention group
Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Arthroscopic Labral Debridement
Description: Patients with Hip Labral tears will be treated with labral debridement
Study NCT06393816 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Durvalumab with etoposide and Carboplatin/Cisplatin
Description: Combination of durvalumab with etoposide and Carboplatin/Cisplatin as First Line Treatment in Patients With Large-cell Neuroendocrine Carcinomas of the Lung.~All patients (either with confirmed diagnosis or not) will be treated and followed-up:~* During the induction: every 3 weeks for 12 weeks (4 cycles)~* During the maintenance: every 4 weeks for 24 months
Study NCT04986605 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Extracorporeal Photopheresis (ECP)
Description: Drug Intervention using a medical device. The ECP device is already licensed in Canada. License No.7703. ECP treatment, using the drug UVADEX, will be given on 2 consecutive days every 4 weeks for a total of 26 treatment days (48 weeks).
Study NCT04986605 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: UVADEX
Description: The phase II aspect of the study refers to the drug, methoxsalen. Methoxsalen is being used off label from the currently approved indications in the monograph. The study is proposing to use methoxsalen in combination with with extracorporeal photopheresis for the treatment of diffuse cutaneous systemic sclerosis. Treatment will be given in addition to standard of care medications for SSc.
Study NCT06556680 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Optical coherence tomography
Description: In the OCT-guided biopsy arm, n=100 study subjects will be enrolled. The investigators will conduct biopsies and imaging using our newly developed OCT catheters and real-time image processing and display algorithms.
Study NCT04889092 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Blood Flow Restriction exercise
Description: Exercise training will consist of blood flow restriction exercise. Specifically blood pressure cuff will be wrapped around the most proximal portion of the thigh and inflated to a pressure that is 80% of the pressure required to completely occlude femoral blood flow. With the cuff inflated the subject will perform a series of knee extension/flexion exercise protocol. This consists of 30 reps, 15 reps, 15 reps and 15 reps all separated by 1 minute of recovery. All reps will be performed at 30% of the subjects 1 repetition max. This will be preformed 20 times over 8 weeks.
Study NCT04889092 — intervention group
Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Traditional resistance exercise
Description: Traditional knee extension/flexion exercise will be performed. This will consist of a series of 13 reps, 12 reps, 12 reps with 1 minute recovery between each set. The resistance will be set at 60% of their 1 repetition max. This will be performed 20 times across 8 weeks.
Study NCT05914584 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Baricitinib 4 MG
Description: Reference drug
Study NCT05914584 — intervention group
Intervention type: DRUG
Group type: SHAM_COMPARATOR
Intervention: Baricitinib 4 MG
Description: Reference drug