AIM-Harvard/TrialPanorama-filtered huggingface dataset:
Study NCT05876143 — intervention group
Intervention type: DEVICE
Intervention: Unicompartmental knee arthroplasty
Description: Knee joint could be subject to natural or pathological wear or shocks (primary or secondary evolutive or traumatic osteoarthritis) which cause pain and reduced mobility of the knee.~When only one lateral or medial compartment of the femoro-tibial knee joint is affected, the treatment of unicompartmental femoro-tibial osteoarthritis of the knee is generally carried out by the implantation of a so-called unicondylar knee prosthesis (UKP), in order to reduce pain and improve joint mobility of the knee compared to the preoperative state.
Study NCT06359743 — intervention group
Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Quadratus Lamborum versus superior hypogatric
Description: Ultrasound Guided Quadratus Lumborum Block versus Laparoscopic Superior Hypogastric Plexus Block for Postoperative Analgesia after Laparoscopic Hysterectomy
Study NCT06441110 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Tislelizumab in Combination with Bacillus Calmette-Guérin
Description: Postoperative immediate instillation of epirubicin (50mg) is administered. Postoperatively, 200mg of tislelizumab injection is given intravenously every 3 weeks, with each 21-day period constituting one cycle. The medication is administered on day 1 of each cycle, continuing for one year. Eligible patients for the single-arm group (N = 76) begin BCG instillation after 2 weeks, with a dosage of 120mg per instillation, totaling 19 instillations: this starts with a 6-week induction phase of weekly BCG instillations, followed by BCG instillations every 2 weeks for three consecutive times; thereafter, maintenance instillation therapy commences, involving monthly BCG instillations for a total of ten times.
Study NCT05729425 — intervention group
Intervention type: DEVICE
Intervention: Ultrasound Microvessel Imaging
Description: Undergo microvessel ultrasound imaging
Study NCT05364983 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Juvene IOL
Description: Cataract extraction and implantation of a posterior chamber IOL
Study NCT05364983 — intervention group
Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Tecnis® Monofocal (ZCB00, PCB00 or DCB00)
Description: Cataract extraction and implantation of a posterior chamber IOL
Study NCT05226559 — intervention group
Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Multimodal Physical therapy approach plus usual care
Description: HVLA spinal manipulation, mobilization, soft tissue treatment, therapeutic exercise, education, plus standard pharmacological treatment.
Study NCT05226559 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Usual care
Description: Standard pharmacological treatment alone.
Study NCT06365515 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Levodopa administration
Description: To boost dopamine levels 150mg/37.5 mg L-DOPA/benserazide will be administered in line with recent studies (Kroemer et al., 2019). Maximum plasma concentration of Madopar occur \~60 minutes after drug administration. Participants will start the Effort Allocation Task 45 minutes after Levodopa administration.
Study NCT06365515 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo administration
Description: Placebo tablets will be administered as the placebo-controlled condition.
Study NCT06521801 — intervention group
Intervention type: OTHER
Intervention: Observation
Description: Observation
Study NCT06294821 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: 4-Aminopyridine
Description: Subjects will receive either the active study drug (4-aminopyridine) or placebo to determine the effects of 4AP on carpal tunnel syndrome
Study NCT06294821 — intervention group
Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Subjects will receive either the active study drug (4-aminopyridine) or placebo to determine the effects of 4AP on carpal tunnel syndrome
Study NCT05880212 — intervention group
Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Usual physiotherapy care
Description: In Phase 1, physiotherapists will provide treatment for participants with chronic low back pain in accordance with their current standard physiotherapy practice. Physiotherapists will be free to choose the treatment approach they wish to.
Study NCT05880212 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Individualized (STOPS) physiotherapy
Description: In Phase 3, participants will receive individualized physiotherapy in accordance with the Specific Treatment of Problems of the Spine (STOPS) approach modified for chronic low back pain. Treatment will be individualized on the basis of biopsychosocial assessment findings including dominant pain type (nociceptive, neuropathic or nociplastic), pathoanatomical subgroups (if any), and other barriers to recovery (eg. inflammation, depression, anxiety, stress, catastrophising, pain self-efficacy, and unhelpful motor control strategies). Available treatment strategies will include individualized education/advice, exercise, manual therapy, activity modification/facilitation, goal setting, motor control optimisation, cognitive-behavioural strategies, inflammation management, pain management strategies, sleep management, work management, and relaxation approaches.
Study NCT05378828 — intervention group
Intervention type: DEVICE
Group type: OTHER
Intervention: Using anti-collision Sensors on electric wheelchairs
Description: use of anti-collision sensors on the electric wheelchair during 3 weeks
Study NCT05378828 — intervention group
Intervention type: OTHER
Group type: OTHER
Intervention: Use of an electric wheelchair without sensors
Description: Use of an electric wheelchair without sensors for 3 weeks before using anti-collision sensors then during 3 weeks after using the anti-collision sensors.
Study NCT05615402 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Bone-specific strength training
Description: Muscular strength and rate of force development (RFD) will be assessed in the key exercises of the intervention protocol
Study NCT05615402 — intervention group
Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Nutrition optimalisation
Description: Dietary supplement of protein, vitamin D and Calcium 3x/w Dietary counselling based on individual dietary records
Study NCT04861584 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Neoadjuvant Toripalimab in Combination With Gemcitabine and Cisplatin
Description: 4 cycle neoadjuvant therapy and radical cystectomy
Study NCT06411834 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Decision navigation tool
Description: An electronic, interactive form that guides patients through the major factors that influence their decision-making in thyroid cancer
Study NCT05035004 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Post exercise hot water immersion
Description: Participants will complete 30 minutes of cycling on a lode bicycle ergometer (50% of VO2max), followed by a 10-minute transfer period and then 30 minutes of whole-body hot water immersion in a hot tub (water temperature 40°C).
Study NCT05035004 — intervention group
Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Exercise
Description: Participants will complete 30 minutes of cycling on a lode bicycle ergometer (50% of VO2max).
Study NCT05907330 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: CU104
Description: CU104 will administer the study drug once a day after a meal
Study NCT05907330 — intervention group
Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Placebo will administer the study drug once a day after a meal
Study NCT06218264 — intervention group
Intervention type: DIETARY_SUPPLEMENT
Group type: ACTIVE_COMPARATOR
Intervention: Ingestion of an amino acid supplement
Description: Oral intake of a supplement containing amino acids
Study NCT05344651 — intervention group
Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Surgery/implantation
Description: The glaucoma drainage device consists of a plate and a tube. During surgery the plate is positioned underneath the conjunctiva and two extraocular muscles in the upper temporal quadrant of the eye. The tube is positioned in the anterior chamber.
Study NCT05344651 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Surgery/implantation
Description: The glaucoma drainage device consists of a plate and a tube. During surgery the plate is positioned underneath the conjunctiva and two extraocular muscles in the upper temporal quadrant of the eye. The tube is positioned in the anterior chamber.
Study NCT06409650 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: KX-826 dosed at 2.5mg
Description: 2.5mg of the investigational drug to be applied topically to scalp once daily for 24 weeks
Study NCT06409650 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: KX-826 dosed at 2.5mg
Description: 2.5mg of the investigational drug to be applied topically to scalp twice daily for 24 weeks
Study NCT06409650 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: KX-826 dosed at 5 mg
Description: 5mg of the investigational drug to be applied topically to scalp once daily for 24 weeks
Study NCT05035004 — intervention group
Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Hot water immersion
Description: Participants will complete 30 minutes of whole-body hot water immersion in a hot tub (water temperature 40°C), followed by a 10-minute transfer period and then an additional 30 minutes of whole-body hot water immersion in a hot tub (water temperature 40°C).
Study NCT05626855 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Apitegromab
Description: Apitegromab (SRK-015) is an investigational, fully human immunoglobulin G4 monoclonal antibody that specifically binds to human proforms (i.e., inactive precursor forms) of myostatin, pro- and latent- myostatin, with high affinity, inhibiting activation of myostatin, a negative regulator of muscle growth and strength.
Study NCT03875339 — intervention group
Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Navigator Guidance
Description: Use of a dedicated Navigator to determine if follow-up and compliance rates can be improved for those infants initially demonstrating an abnormal hearing result.
Study NCT05822661 — intervention group
Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Black Seed Oil
Description: Dietary supplement
Study NCT05822661 — intervention group
Intervention type: DIETARY_SUPPLEMENT
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: placebo capsules same odor, color and size as the drug but without the active ingredient
Study NCT06409650 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: KX-826 dosed at 5 mg
Description: 5mg of the investigational drug to be applied topically to scalp twice daily for 24 weeks
Study NCT06409650 — intervention group
Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Matching placebo to KX-826
Description: Placebo applied topically to scalp once daily for 24 weeks
Study NCT06409650 — intervention group
Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Matching placebo to KX-826
Description: Placebo applied topically to scalp twice daily for 24 weeks
Study NCT06376292 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Intrathecal Injection of Thiotepa+Radiation+Systemic Treatment of Primary Diseases
Description: Participants will receive a comprehensive treatment plan consisting mainly of whole brain 30Gy/10F radiotherapy combined with intrathecal injection of Thiotepa. The injection was administered by qualified individuals (certified personnel in the radiotherapy department of our hospital) twice a week for a total of 4 weeks. Thiotepa was injected 10mg each time, mixed with cerebrospinal fluid, and then injected slowly for 5-10 minutes.
Study NCT05357313 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Bright light therapy
Description: Exposure to 10,000lux bright light for 30minutes a day for six weeks
Study NCT05357313 — intervention group
Intervention type: DEVICE
Group type: PLACEBO_COMPARATOR
Intervention: Inactive negative ion generator
Description: Exposure to an inactive negative ion generator for 30 minutes a day for six weeks
Study NCT05454228 — intervention group
Intervention type: BEHAVIORAL
Intervention: postoperative delirium
Description: Postoperative delirium (POD) occurs within 1 week after surgery in patients, with obvious time characteristics, mainly occurring within 1-3 days after surgery. Postoperative delirium has adverse effects on the short and long term prognosis of patients. Patients with delirium have an increased risk of postoperative complications, perioperative death, longer hospital stay and increased medical costs during hospitalization.
Study NCT04275531 — intervention group
Intervention type: DRUG
Intervention: Anesthesia Agent
Description: various anesthetic agents used in both general and regional anesthesia
Study NCT06335862 — intervention group
Intervention type: OTHER
Group type: OTHER
Intervention: Randomisation between the PPT- and no-PPT-group
Description: Randomisation is performed between two possible treatment options for tracheomalacia in OA patients; the PPT or the wait-and-see policy (no-PPT).
Study NCT06335862 — intervention group
Intervention type: PROCEDURE
Group type: OTHER
Intervention: Primary Posterior Tracheopexy
Description: The PPT involves fixating the posterior membrane of the trachea to the spinal ligament with sutures, to prevent the trachea from collapsing.
Study NCT06335862 — intervention group
Intervention type: DIAGNOSTIC_TEST
Group type: OTHER
Intervention: Preoperative tracheobronchoscopy
Description: Prior to OA correction, a flexible and a rigid tracheobronchoscopy will be performed, in addition to a flexible tracheobronchoscopy through the endotracheal tube. Preoperative evaluation of TM through a tracheobronchoscopy is part of standard care for all participating centres.
Study NCT06335862 — intervention group
Intervention type: DIAGNOSTIC_TEST
Group type: OTHER
Intervention: Intraoperative tracheobronchoscopy
Description: After the PPT is performed, or in case of the no-PPT group at the stage of the surgery when the PPT would usually be performed, a flexible tracheobronchoscopy through the endotracheal tube is carried out. This tracheobronchoscopy is routine care for all patients undergoing a PPT, and is additional for patients in the no-PPT-group.
Study NCT06335862 — intervention group
Intervention type: DIAGNOSTIC_TEST
Group type: OTHER
Intervention: Postoperative tracheobronchoscopy through the endotracheal tube during extubation
Description: A postoperative flexible tracheobronchoscopy is performed in the neonatal or pediatric intensive care unit (ICU), through the endotracheal tube during extubation. This procedure is a study intervention.
Study NCT06335862 — intervention group
Intervention type: DIAGNOSTIC_TEST
Group type: OTHER
Intervention: Postoperative tracheobronchoscopy after 2-6 months
Description: Two to six months after OA correction, a follow-up flexible and a rigid tracheobronchoscopy will be performed, under general anesthesia in the surgical theatre. This postoperative evaluation of TM through a tracheobronchoscopy is part of standard care for the Karolinska University Hospital and Great Ormond Street Hospital. At the University Medical Centre Utrecht and Erasmus Medical Centre Rotterdam, this tracheobronchoscopy is performed on indication in approximately half of patients. For the other half of patients, this is a study intervention.
Study NCT05070702 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: CT-1500
Description: Hard Capsule
Study NCT05070702 — intervention group
Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Hard Capsule
Study NCT05383859 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Intervention
Description: 1. Dietary and/ or physical activity: face to face plus written material (at baseline)~2. 3 months later: motivational phone call.
Study NCT06363253 — intervention group
Intervention type: OTHER
Intervention: No specific intervention
Description: Patient will undergo their routine clinical treatment for their related clinical condition (eg. anti-obesity or bariatric intervention for obese group; muscle strengthening interventions or necessary treatment for their concomitant medical condition for the sarcopenia group).~Follow-up testing will include repeat assessment of the subjects metagenome and metabolome over time, and after intervention~Control subjects will have no interventions performed as well.
Study NCT05493254 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Smoking cessation e-visit
Description: electronic visits (e-visits) for smoking cessation
Study NCT05493254 — intervention group
Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Treatment As Usual
Description: Information about the state quitline and about the importance of quitting smoking and a recommendation to contact one's PCP to schedule a medical visit to discuss quitting smoking.
Study NCT06238869 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Computerized Cognitive Behavioral Therapy
Description: CCBT (Computerized Cognitive Behavioral Therapy) is a unique approach to improving mental well-being. It utilizes computer-based cognitive and behavioral techniques to induce relaxation and regulate emotional responses by targeting specific brain regions. CCBT offers interactive and personalized interventions, empowering individuals to address mental health challenges like depression and anxiety. Its convenience and accessibility through digital platforms make it a practical choice for enhancing emotional well-being.
Study NCT06238869 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Music Therapy
Description: Music Therapy can make peoples gradually relax via relaxing and soothing music, and regulate individual psychological emotions through the influence of music on individuals' cerebral cortex, hypothalamus and limbic system, further improve the mood of daily tension and anxiety.
Study NCT06238869 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Health education
Description: Health education focuses on providing insights into adolescent mental health, offering practical coping strategies and behavior patterns. It emphasizes the crucial link between parental guidance and the well-being of adolescents. By fostering healthier psychological interactions, it cultivates an environment supportive of adolescent mental health, strengthens family support, and promotes comprehensive development in physical, mental, and cognitive aspects.
Study NCT05904925 — intervention group
Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Pilates exercises
Description: Sessions will last 60 minutes: five minutes for warming up, 50 minutes for the practice of Pilates exercises, and five minutes for relaxing with the Swiss ball. The exercise protocol will be divided into three gestational phases, covering the entire gestational period, with different and specific objectives for each phase. In all phases, the exercises will be classified into three levels of difficulty: basic, intermediate, and advanced, according to the evolution of each pregnant woman throughout the practice of Pilates. Modifications will be allowed to facilitate or hinder the execution of the movement. The exercises will be performed in one or two sets of seven to 10 repetitions. The number of series, repetitions and exercises and interval time between them, as well as the level of difficulty of the exercises, will be gradually adjusted. The intensity of the exercises will vary between light and moderate and will be controlled by the Borg scale.
Study NCT05968859 — intervention group
Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Aerobic Training
Description: Aerobic training will be conducted at 30 minutes 3 times a week using brisk walking with target heart rates goals based on percentage of peak HR reserve (HRR= peak-rest HR) during baseline exercise right heart catheterization (RHC). The target HR will progress over the study period from 50% to 70% of peak HR reserve added to resting HR using the standard Karvonen formula (Goal HR = rest HR + target % of HRR). HR will be monitored using Fitbits to guide training intensity with raw data analyzed using the Fitabase platform to monitor compliance
Study NCT05968859 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Leg Training
Description: Leg training will be performed using assigned ankle weights to perform knee extension while seated. Initial weight assignment will be guided by a protocol driven in-person exercise tolerance test using varying weights to identify the optimal initial and target training weight for each patient based on the 10 repetition maximum weight identified during this test. Leg training weight will begin at 40% of the baseline 10-repetition maximum weight for weeks 1-4 during which time patients will be required to complete 3 sets of 10 repetitions (30 repetitions total) on 3 days per week. For weeks 4-8, 55% of the initial 10-repetition maximum weight will be used for 4 sets of 10 repetitions (40 repetitions total). For weeks 8-12, 70% of the initial 10-repetition maximum weight will be used for 5 sets of 10 repetitions (50 repetitions total).
Study NCT04683107 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Eccentric protocol
Description: Participants in this arm will perform progressive eccentric exercise protocol
Study NCT04683107 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Isometric protocol
Description: Participants in this arm will perform progressive isometric exercise protocol
Study NCT05210205 — intervention group
Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: EAA
Description: EAA-enhanced protein snack bars
Study NCT05210205 — intervention group
Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Energy Dense
Description: Energy dense snack bars (same calories in a smaller volume of food)
Study NCT05210205 — intervention group
Intervention type: DIETARY_SUPPLEMENT
Group type: ACTIVE_COMPARATOR
Intervention: Control
Description: Low energy dense snack bars (same calories in a greater volume of food)
Study NCT04766138 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Fecobionics
Description: Fecobionics is a new device to be inserted through the anal canal into rectum for studying defecation
Study NCT04721041 — intervention group
Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Washed Microbiota Transplantation (WMT)
Description: Washed microbiota suspension (5u) delivered through nasogastric tube, nasojejunal tube or oral. Dose and frequency: 5u, three times.