AIM-Harvard/TrialPanorama-filtered huggingface dataset:
Study NCT05464979 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Esketamine Hydrochloride 28 Mg in 0.2 mL NASAL SOLUTION [Spravato]
Description: Esketamine at 0.5-1.0 mg/kg BW and rocuronium bromide at 0.6 mg/kg BW was given intravenously for induction intubation. After the intubation was completed, esketamine was continuously pumped at 0.3-1.5 mg/kg/h to maintain sedation.
Study NCT05464979 — intervention group
Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: midazolam, fentanyl
Description: Midazolam at 0.1mg/kg BW, fentanyl at 1ug/kg BW, rocuronium bromide at 0.6mg/kg BW was given intravenously for induction intubation; After the intubation was completed, sufentanil at 0.1 μg/kg/h was administered for analgesia, and remazolam tosylate at an initial dose of 0.075 mg/kg/h was administered for sedation, and the dose of remazolam tosylate was adjusted according to the RASS score.
Study NCT05802628 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Cetylpyridinium Chloride Buccal Tablets
Description: Subjects administrated single dose of Cetylpyridinium Chloride Buccal Tablet
Study NCT06531278 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Irinotecan liposome
Description: * Patients are planned to receive irinotecan liposomal (60 mg/m2; d1) of every cycle.~* 27 days a cycle
Study NCT06531278 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Adebrelimab
Description: * Patients are planned to receive Adebrelimab (20 mg/kg; d1) of every cycle.~* 27 days a cycle
Study NCT06531278 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Oxaliplatin
Description: * Patients are planned to receive Oxaliplatin (85 mg/m2; d1) of every cycle.~* 27 days a cycle
Study NCT06531278 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Fluorouracil
Description: * Patients are planned to receive fluorouracil (2400mg/m2; d1) of every cycle.~* 27 days a cycle
Study NCT06531278 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Calcium folinate
Description: * Patients are planned to receive Calcium folinate (400mg/m2; d1) of every cycle.~* 27 days a cycle
Study NCT05092893 — intervention group
Intervention type: OTHER
Intervention: Online parental questionnaires
Description: The SRS-2 is a parental 65-item questionnaire to detect difficulties in social responsiveness in children with autism spectrum disorder. Four different forms are available: preschoolers (2.5-4.5 years), school-aged children (4-18 years), adults (≥ 19 years) and adults self-report. In this study, only the form for school-aged children will be used.~The DCDQ'07 is a parental 15-item questionnaire to detect the risk of DCD in children between 5 and 15 years of age. Parents are asked to compare their child's motor performance to his/her peers using a 5-point Likert scale. The total sum score is compared to age-specific cut-off scores to determine the risk of DCD. Belgian norms are available since 2007.
Study NCT04761926 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Audiometry
Description: Audiometry: Thresholds from the audiogram obtained when Ponto 4 were fitted. Pure tone air conduction (AC) and bone conduction (BC) audiometry conducted at the visit.~Speech recognition in quiet: Speech intelligibility is measured in a soundproof room using the Matrix sentences presented from a loudspeaker. The Matrix test includes five-word sentences with a fixed syntactical structure and limited contextual cues. A list of 20 sentences is compiled from these words, ensuring that no sentence is repeated twice. This test will be obtained both unaided and aided (with and without the Ponto 4(s)).~Sound field Audiometry: Detection of sound field thresholds presented from a loudspeaker. Thresholds will be obtained both unaided and aided and the test order will be balanced between subjects. During these measurements, the Ponto 4 will be programmed in omni-directional mode, with noise reduction and feedback management system turned off.
Study NCT04796831 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Quizartinib dihydrochloride
Description: Single oral dose of 60 mg quizartinib (2 x 30 mg tablets)
Study NCT04796831 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: 14C-Quizartinib solution for infusion
Description: 50 μg solution for infusion containing NMT 22.84 kBq 14C in 5 mL; administered once as a 15-minute infusion
Study NCT05416346 — intervention group
Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Digital Cognitive Behavioral Therapy
Description: Cognitive behavioral therapy for insomnia (CBT-i) has been showed to be effective in reducing insomnia symptoms and insomnia-related symptoms, including sleepiness, dysfunctional beliefs and attitudes about sleep, anxiety and depressive symptoms
Study NCT05416346 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Digital Cognitive Behavioral Therapy
Description: Cognitive behavioral therapy for insomnia (CBT-i) has been showed to be effective in reducing insomnia symptoms and insomnia-related symptoms, including sleepiness, dysfunctional beliefs and attitudes about sleep, anxiety and depressive symptoms
Study NCT05416346 — intervention group
Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Sleep Hygiene Education (SHE)
Description: The SHE group received sleep hygiene education delivered in text form, and the same intervention as the dCBT-i group did after four weeks.
Study NCT06522828 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: SSGJ-707
Description: SSGJ-707 is a bispecific antibody against human PD-1 and VEGF
Study NCT06390683 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Rewilding
Description: Yards of the assisted living centers will be modified with berry bushes, fruit trees, perennial yard plants, meadow flowers, cultivation boxes, organic mulch materials, decaying deadwood, leaf compost and organic plant growing media with high microbial diversity.
Study NCT04643626 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: artificial intelligence dietary android mobile application
Description: subjects use artificial intelligence dietary mobile application to monitor dietary intake
Study NCT06522828 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: carboplatin
Description: chemotherapy
Study NCT06522828 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: paclitaxel
Description: chemotherapy
Study NCT05271916 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Dacomitinib+Anlotinib
Description: The dose of each drug in the combination Decomitinib and Anlotinib will be escalated or de-escalated until the recommended phase II dose (RP2D) is reached. Patients will then be treated with RP2D orally once a day.
Study NCT05271916 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Dacomitinib
Description: Dacomitinib orally on a continuous daily basis at a starting dose of 45 mg once a day until progressive disease.
Study NCT05071846 — intervention group
Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: MVX-ONCO-2
Description: One administration of MVX-ONCO-2 (or vaccination) consists of the implantation of 2 capsules containing MVX-2 cells and 1 injection of 4 × 10\^6 lethally irradiated autologous tumor cells. Tumor cells will have prealably been harvested from the participant through a surgical procedure.~A full treatment course with MVX-ONCO-2 consists of a total of 6 vaccinations: 4 vaccinations 1 week apart, followed by 2 boosters 2 weeks apart. Capsules are removed 1 week after implantation.
Study NCT05810532 — intervention group
Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: 4 hours of fasting time
Description: Oral intake is not allowed for 4 hours before sedation including water
Study NCT05810532 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: 1 hour of fasting time
Description: Oral intake is not allowed for 4 hours before sedation, while water is allowed to intake before 1 hour of sedation
Study NCT05229718 — intervention group
Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Diabetes Collaborative Care Model for Young Adults
Description: We designed a diabetes collaborative care model for young adults that incorporates a mental health provider alongside a diabetes care provider during joint office visits to facilitate screening and treatment of psychosocial determinants of diabetes management. The Massachusetts General Hospital (MGH) Diabetes Center will be piloting this model with a multi-disciplinary team of diabetologists, nurse practitioners, diabetes nurse educators, and mental health provider. Patients scheduled to be seen in the diabetes collaborative care model will continue to follow in the diabetes collaborative care model, with follow up visits every 3-4 months. All patients will receive routine diabetes care with lab testing, medical interventions, therapies and referrals performed at the discretion of the patients' providers.
Study NCT05229718 — intervention group
Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Usual Care Model
Description: Patients enrolled in this arm will receive routine diabetes care per usual care at the Massachusetts General Hospital (MGH) Diabetes Center, with lab testing, medical interventions, therapies and referrals performed at the discretion of the patients' providers. In the usual care model, behavioral/mental health and social work services are available on a referral basis and are not integrated into a patients' routine appointment. Screening and treatment of psychosocial determinants of diabetes management are at done at the discretion of the patients' provider. Frequency of follow up visits is at the discretion of the patients' provider.
Study NCT04744935 — intervention group
Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: 1064 nm long-pulse Nd:YAG laser
Description: BCC lesion will be treated with long-pulse 1064 laser, with surface temperature monitored by infrared camera.
Study NCT06295861 — intervention group
Intervention type: OTHER
Intervention: no different intervention between the two cohort.
Description: no different intervention between the two cohort.
Study NCT05663580 — intervention group
Intervention type: DRUG
Intervention: Cabotegravir 600mg/3mL, Rilpivirine 900mg/3mL
Description: Initial administration of two separate intramuscolar injection of cabotegravir 400mg/3mL and rilpivirine 600mg/3mL in opposite gluteal muscles, repeated one month later and then every two months.
Study NCT04809285 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Guardian™ Connect system, InPen™ Basal smart cap, smart insulin pens, and InPen™ Diabetes Management app
Description: Guardian™ Connect system consists of Guardian™ Connect app, Guardian™ Connect transmitter, and Guardian Sensor (3), will be working with InPen™ Basal smart cap and smart insulin pens and InPen™ Diabetes Management app for multiple daily injections. The subject's insulin delivery, sleep, physical activity (as applicable), food intake data, and medication (as applicable) will be collected through applications with meal logging and medication requiring manual entry. In addition, subjects may also participate in optional self-administered insulin injection video capture and upload using a secure cloud-based site and/or monthly menstrual cycle logging using Apple Health and/or cardiac monitoring using BodyGuardian MINI.
Study NCT04690959 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: neural mobilization
Description: Neural mobilization, or neurodynamics, is a movement-based intervention aimed at restoring the homeostasis in and around the nervous system.
Study NCT04690959 — intervention group
Intervention type: OTHER
Group type: SHAM_COMPARATOR
Intervention: Sham intervention
Description: it is faked neural mobilization that mimic the neural mobilization treatment but believed not to stress the neural tissues in the upper extremity.
Study NCT06251765 — intervention group
Intervention type: OTHER
Intervention: Clinical scores
Description: Clinical scores will be administered to patients
Study NCT06251765 — intervention group
Intervention type: OTHER
Intervention: Range of Motion
Description: Evalutation of knee mobility
Study NCT05891795 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Clascoterone 1% Top Cream
Description: Apply a thin layer to the affected area twice daily.
Study NCT05891795 — intervention group
Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Vehicle
Description: Apply a thin layer to the affected area twice daily.
Study NCT06177626 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Aerobic Training
Description: Aerobic training on stationary bike 5x a week for 30 minutes a day
Study NCT06177626 — intervention group
Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Balance Training
Description: Training 5x a week for 30 minutes. Standard of care.
Study NCT04691674 — intervention group
Intervention type: PROCEDURE
Group type: PLACEBO_COMPARATOR
Intervention: Endoscopy
Description: Endoscopic removal of the pancreatic stent
Study NCT04691674 — intervention group
Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Endoscopy
Description: Endoscopic removal of the pancreatic stent
Study NCT05026424 — intervention group
Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Balance oral nutritional drink - control
Description: Drink 1 cup of liquid nutrition product that contains protein, carbohydrate and fat intended for use as supplemental nutrition.
Study NCT05026424 — intervention group
Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Balance oral nutritional drink - test
Description: Drink 1 cup of liquid nutrition product that contains protein, carbohydrate and fat designed for people living with diabetes and intended for use as supplemental nutrition.
Study NCT05637515 — intervention group
Intervention type: BIOLOGICAL
Group type: ACTIVE_COMPARATOR
Intervention: Humira 40 MG in Prefilled Syringe
Description: Humira (40 mg every other week)
Study NCT05637515 — intervention group
Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Hulio 40 MG in Prefilled Syringe / Humira 40 MG in Prefilled Syringe
Description: • Subjects will receive Humira (initial dose of 80 mg \[2 × 40 mg\]; Day 1 administered subcutaneously (SC), followed by 40 mg SC given every other week starting 1 week after the initial dose (last dose at Week 10).~Hulio (40 mg every other week) at Week 12 and Week 14~* Humira (40 mg every other week) at Week 16 and Week 18, and~* Hulio (40 mg every other week) at Week 20, Week 22, Week 24 and Week 26.
Study NCT06427382 — intervention group
Intervention type: DEVICE
Intervention: Perfusion index
Description: Perfusion index determination using non-invasive pulse oximetry
Study NCT04897854 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Folfirinox
Description: In both arms the intervention will be FOLRINIOX or nab paclitaxel in combination with gemcitabine per investigator's choice
Study NCT06335784 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Imagery Rescripting (IR)
Description: Imagery rescripting (IR) is a technique where the individual is instructed to imagine a negative memory or image as vividly as possible, and to change it in a direction that he/she desires. IR seems particularly efficient because it is based on the experienced emotions during perceptual information processing, thereby eliciting stronger emotional responses than verbal processing.
Study NCT06335784 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Imagery Rescripting (IR) and Targeted Memory Reactivation (TMR) during sleep
Description: Targeted Memory Reactivation (TMR) is a technique used to strengthen a memory trace during sleep. TMR is used to modify memory formation through the application of cues during sleep. In this TMR protocol, an olfactory cue is associated with the imagery rescripting (IR) during the day, and then administered during sleep. In that way, the replay of the associated memory and its corresponding neural representation in memory networks are artificially promoted, a procedure which usually strengthens memory consolidation. Previous studies have shown that TMR in sleep reduces emotional arousal, making it a promising technique for insomnia.
Study NCT06335784 — intervention group
Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Sleep Hygiene
Description: Sleep hygiene education includes modifications in the behavior (e.g., exercise, coffee, alcohol intake) and environment (e.g., light, noise, temperature conditions) that offer to the individual the foundation for healthy sleep. Sleep hygiene is an important component in treating ID, but insufficient and less effective than CBT-I when offered alone.
Study NCT05500729 — intervention group
Intervention type: OTHER
Intervention: Hamstrings maximal voluntary isometric contraction.
Description: Hamstrings maximal voluntary isometric contraction (MVIC) will be measured with an isometric dynamometer (3 reps x 5 sec work x 10 sec rest). The best rep will be used. Whenever the third one was the best, additional measurements will be taken until a decrease in torque will be obtained to determine the maximum.
Study NCT05500729 — intervention group
Intervention type: OTHER
Intervention: Quadriceps maximal voluntary isometric contraction
Description: Quadriceps maximal voluntary isometric contraction (MVIC) will be measured with an isometric dynamometer (3 reps x 5 sec work x 10 sec rest). The best rep will be used. Whenever the third one was the best, additional measurements will be taken until a decrease in torque will be obtained to determine the maximum.
Study NCT05924009 — intervention group
Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Transcranial Magnetic Stimulation, TMS
Description: The best location for evoking an electromyographic (EMG) response of the first dorsal interosseus (FDI) muscle in the dominant hand and the minimum stimulation intensity required to evoke a certain EMG response amplitude (Motor Threshold, MT) are used as reference to determine the best location and stimulation parameters to evoke GEPs.~After identification of the GEP hot-spot, a water load test is administered to determine whether satiety shapes GEP responses.~In subsequent study visits, the water load test is preceded by application of neuromodulatory repetitive TMS (rTMS), targeted to the GEP hotspot.
Study NCT05629559 — intervention group
Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: 4D-310
Description: Single IV administration of 4D-310 Dose Level 1
Study NCT05629559 — intervention group
Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: 4D-310
Description: Single IV administration of 4D-310 Dose Level 2
Study NCT05629559 — intervention group
Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: 4D-310
Description: Single IV administration of 4D-310 at the selected dose
Study NCT05054088 — intervention group
Intervention type: DEVICE
Intervention: T-Detect COVID test
Description: • The T-DetectTM COVID test is an EUA granted investigational device that is indicated to assess a T-cell immune response to SARS-CoV-2 via the testing of blood samples from patients with signs and symptoms of suspected COVID-19.
Study NCT05584241 — intervention group
Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Diagnostic Disclosure Protocol
Description: Personalized disclosure on cognitive test results and research diagnosis, plus post-disclosure dementia risk reduction counseling.
Study NCT05584241 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Biomarker Disclosure Protocol
Description: Participants receive information about their cognitive test results and research diagnosis just like in the diagnostic disclosure protocol. In addition, participants receive information about whether they currently have elevated or not-elevated amyloid and/or tau based on recent PET imaging. PET is a type of imaging biomarker (Aß-PET and tau PET) for clinical diagnosis of Alzheimer's disease. These actions are followed by post-disclosure dementia risk reduction counseling.
Study NCT06509217 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Moderate-intensity Group
Description: Water aerobics sessions involved exercises performed at a moderate intensity, between 60% and 70% of the participant's maximum heart rate predicted by their age.
Study NCT06509217 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: High-intensity Group
Description: Water aerobics sessions involved exercises performed at a high intensity, between 80% and 90% of the participant's maximum heart rate predicted by their age.
Study NCT06335784 — intervention group
Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Sleep Hygiene + Odor
Description: Sleep hygiene instructions will be applied in the presence of an odor, which will be also used during the night.
Study NCT06335784 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Rocking bed if patients still have insomnia complaints (ISI >10) after the 4 weeks of the intervention
Description: Rocking stimulation boosts brain oscillations in deep sleep (i.e., sleep spindles and slow oscillations) into a rhythmic appearance supporting a neurophysiological mechanism whereby continuous rocking entrains endogenous thalamo-cortical sleep oscillations. The beneficial effects of rocking strengthening the continuity of sleep might have clinical applications and it will be of interest to evaluate if such non-pharmacological could improve sleep and reduce such features of hyperarousal in ID patients.
Study NCT06335784 — intervention group
Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Rocking bed if patients still have insomnia complaints (ISI >10) after the 4 weeks of the intervention
Description: Rocking stimulation boosts brain oscillations in deep sleep (i.e., sleep spindles and slow oscillations) into a rhythmic appearance supporting a neurophysiological mechanism whereby continuous rocking entrains endogenous thalamo-cortical sleep oscillations. The beneficial effects of rocking strengthening the continuity of sleep might have clinical applications and it will be of interest to evaluate if such non-pharmacological could improve sleep and reduce such features of hyperarousal in ID patients.
Study NCT05041283 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Chatbot
Description: A artificial-intelligence based chatbot is provided 3 days before colonoscopy to answer questions concerning bowel preparation and colonoscopy conduct.
Study NCT05041283 — intervention group
Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Phone call
Description: A phone call is performed every day starting at 3 days before colonoscopy to support bowel preparation.
Study NCT05090020 — intervention group
Intervention type: PROCEDURE
Intervention: Treatment
Description: Surgery and PAIR