AIM-Harvard/TrialPanorama-filtered huggingface dataset:
Study NCT04798638 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: TY-9591 Tablets after a High-fat Meal - Arm1
Description: Phase 2 (period 3) allocated high-fat meal prior to dosing with 80 mg TY-9591 tablet (p o, once) and 4 hours after dosing on day 1.
Study NCT04798638 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Osimertinib Mesylate Tablets under Fasted Condition - Arm2
Description: Phase 1 (period 1) fasted from 10 hours prior to dosing with 80 mg Osimertinib Mesylate Tablets (p o, once) and 4 hours after dosing on day 1.
Study NCT04798638 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: TY-9591 Tablets under Fasted Condition - Arm2
Description: Phase 1 (period 2) fasted from 10 hours prior to dosing with 80 mg TY-9591 tablet (p o, once) and 4 hours after dosing on day 1.
Study NCT04798638 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: TY-9591 Tablets after a High-fat Meal - Arm2
Description: Phase 2 (period 3) allocated high-fat meal prior to dosing with 80 mg TY-9591 tablet (p o, once) and 4 hours after dosing on day 1.
Study NCT06636799 — intervention group
Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Microneedling and actives
Description: In this procedure, a derma roller composed of 1.5 mm microneedles from the Smart Derma Roller brand with 540 titanium needles was used. The protocol was performed by passing the derma roller ten times in the following directions: horizontal, vertical, and diagonal right and left. Group G3 received microneedling associated with active ingredients. This manipulated active ingredient was composed of growth factors (EGF Factor, TGFß3 Factor, and IDP-2 Peptide), Hydroxyprolisilane, and hyaluronic acid.
Study NCT06638437 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Cognitive-behavioral therapy
Description: The mobile application will include the following modules:~1. Psychoeducation: information about what to expect from each phase of the surgical process (i.e., pre-operative, the surgery itself and the post-operative).~2. Activation control techniques: to teach different activation control techniques such as relaxation, breathing techniques and mindfulness training.~3. Cognitive restructuring and problem solving: to teach how to change maladaptive pain-related beliefs for more adaptive ones and how to better cope with pain.~4. Exercises and tasks: to encourage the use of the learning strategies we will offer a number of exercises and tasks~5. Parent's module: to teach parents about the surgical process and how they can help their children during the process
Study NCT06637397 — intervention group
Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Probiotic
Description: During the intervention, participants can consume BC99 daily and any adverse reactions were noted. Stool and serum samples were collected for analysis of 16S rRNA and serum inflammatory markers. Changes in intestinal flora and inflammatory factors before and after supplementation were assessed.
Study NCT06637397 — intervention group
Intervention type: DIETARY_SUPPLEMENT
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: During the intervention, participants can consume maltodextrin daily and any adverse reactions were noted. Stool and serum samples were collected for analysis of 16S rRNA and serum inflammatory markers. Changes in intestinal flora and inflammatory factors before and after supplementation were assessed.
Study NCT06637761 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: NeoMTA2
Description: Bio-active bio-ceramic mineral trioxide aggregate
Study NCT06637761 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: WMTA
Description: White Mineral trioxide aggregates
Study NCT05402917 — intervention group
Intervention type: PROCEDURE
Intervention: Erector Spinae Plane Block
Description: Interfascial plane (area) blocks are blocks in which the local anesthetic agent is injected into the potential area between the two fasciae. The ESPB we used in our study is a member of interfascial plane blocks. The erector is applied between the spinal muscle and the transverse process, spreading the drug from the injection site to both cranial and caudal. Unlike other defined interfascial plane blocks, ESPB can show paraspinal block characteristics since the injection site is above the transverse process.
Study NCT06069544 — intervention group
Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: BNT165e
Description: Multi-antigen RNA-based vaccine for active immunization against malaria administered as intramuscular injection
Study NCT06069544 — intervention group
Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Isotonic NaCl solution (0.9%)
Study NCT06054477 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ALE.C04
Description: Q3W
Study NCT06054477 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: ALE.C04
Description: Q3W
Study NCT06054477 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Pembrolizumab
Description: 200mg Q3W
Study NCT06054477 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Pembrolizumab
Description: 200mg Q3W
Study NCT05203146 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: PIMPmyHospital (mobile health tool)
Description: Each participant will first be asked to retrieve a factious patient's laboratory results on the app when randomly made available, and then reach a colleague (role played by a study investigator) when asked to do so by a text message on the app.
Study NCT05203146 — intervention group
Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Conventional method
Description: Each participant will first be asked to retrieve a factious patient's laboratory results from the emergency department's computerized patient data system when randomly made available, and then contact a colleague (role played by a study investigator) when asked to do so (request made by a second study investigator).
Study NCT06556524 — intervention group
Intervention type: BEHAVIORAL
Intervention: observation
Description: Behavioral observation and trauma measurement in live mannequin application
Study NCT06556758 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: stripping massage + conventional therapy
Description: Stripping massage on rhomboid major and minor active trigger point in the direction of muscle fiber from origin to insertion of muscle. Frequency: 3 minutes for 3 times/week for 4 consecutive weeks. Conventional PT including Hot pack for 10 minutes + ischemic compression for 90 secs + CPA glides grade 3 kaltenborn mobilization on thoracic T1 to T4 (5 reps x 1 set) Frequency: 3 times/ week for 4 weeks
Study NCT06556758 — intervention group
Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Conventional therapy
Description: conventional therapy including Hot pack for 10 minutes + ischemic compression for 90 secs + CPA glides grade 3 kaltenborn mobilization on thoracic T1 to T4 (5 reps x 1 set ) Frequency : 3 times/ week for 4 weeks
Study NCT04903665 — intervention group
Intervention type: DEVICE
Intervention: Multi-cancer early detection test
Description: Blood collection and multi-cancer early detection testing
Study NCT05938530 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Sirolimus drug-coated balloon
Description: The effectiveness of sirolimus coated balloon in patients with dialysis access dysfunction has been shown in a small pilot study in the salvage of thrombosed arteriovenous graft.
Study NCT05938530 — intervention group
Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Stent graft
Description: Stent graft has been shown to be superior than plain balloon angioplasty in the treatment of AVG dysfunction.
Study NCT05044091 — intervention group
Intervention type: DRUG
Intervention: PARP inhibitor
Description: Ovarian/fallopian tube/primary peritoneal cancer patients with PARP inhibitors according to the NCCN guideline and their instructions
Study NCT06556264 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Dupilumab
Description: Dupilumab 300mg every 2 weeks for 24 weeks
Study NCT06556264 — intervention group
Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Placebo 300mg every 2 weeks for 24 weeks
Study NCT06643468 — intervention group
Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: participants will receive immediate implant with nano-crystalline putty hydroxyapatite as bone graft and collagen membrane.
Description: 1. Injection of local anesthetic Articaine hydrochloride 4% with Epinephrine (1:100,000).~2. Atraumatic removal of remaining root or tooth then implant will be placed according to the standard protocol.~3. Sulcular incision with be made 15c blade .~4. Implant placement with copious irrigation.~5. Membranes placement: collagen followed by insertion of nano-crystalline putty hydroxyapatite.~6. Customized healing abutment application.~7. Suturing of wound edges with 0.5 suture around the customized healing abutment.
Study NCT04952467 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: 14C-XEN1101
Description: Subjects will receive a single oral administration of a capsule containing 20 mg XEN1101
Study NCT06265168 — intervention group
Intervention type: OTHER
Intervention: Simulation
Description: Physicians will participate in a simulated scenario of an adult comatose patient. The intervention will be presented as a learning situation where the physician interacts with a high-fidelity mannequin. The mannequin simulating the patient will manifest a Glasgow Coma Score of 3 (improving over time to a GCS of 4) and a range of physiological and pathological symptoms. Physicians will have access to emergency equipment, including intubation equipment, a defibrillator, and medications. A trained nurse will be present to assist with the simulation. After 20 minutes the patient will regain consciousness in order to avoid a frustrating experience for the physicians. After simulation termination, a senior physician will join the resident and ask him to report the current scenario and will stop the simulation. The entire scenario will be video-recorded.
Study NCT06676449 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Immunotherapy
Description: PD-1 inhibitors will be administered intravenously, a fixed dose of 200 mg, once every 3 weeks for 1 year.
Study NCT06676449 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: chemotherapy: Paclitaxel/Cisplatin
Description: Paclitaxel 135mg/m2 d1, cisplatin 25mg/m2 d1-3, once every 3 weeks for 4 cycles.
Study NCT06676449 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: chemotherapy: Paclitaxel/Cisplatin
Description: Paclitaxel 135mg/m2 d1, cisplatin 25mg/m2 d1-3, once every 3 weeks for 4 cycles.
Study NCT06676449 — intervention group
Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: TDLN-sparing RT
Description: TDLN-sparing radiotherapy 50.4Gy/28Fx.
Study NCT06676449 — intervention group
Intervention type: RADIATION
Group type: ACTIVE_COMPARATOR
Intervention: TDLN-sparing RT
Description: TDLN-sparing radiotherapy 50.4Gy/28Fx.
Study NCT06602414 — intervention group
Intervention type: PROCEDURE
Intervention: Conservative treatment
Description: Conservative treatment instead of surgical repair
Study NCT06677840 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: probiotic (GKB7/placebo)
Description: The objectives of this double-blind randomized placebo-controlled trial are to evaluate the tolerability, safety, and efficacy of the probiotic intervention with Clostridium butyricum GKB7 among 90 4-15-year-old children and adolescents with a clinical diagnosis of ASD according to the DSM-5
Study NCT06677840 — intervention group
Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: probiotic (GKB7/placebo)
Description: The objectives of this double-blind randomized placebo-controlled trial are to evaluate the tolerability, safety, and efficacy of the probiotic intervention with Clostridium butyricum GKB7 among 90 4-15-year-old children and adolescents with a clinical diagnosis of ASD according to the DSM-5
Study NCT06677632 — intervention group
Intervention type: OTHER
Intervention: Palmitoylation Enzyme Expression Profiling Study
Description: The expression of 23 zDHHC enzymes will be studied in human post-mortem hippocampi of AD patients and controls that have already been collected from UK brain biobanks. zDHHC enzymes will be analyzed at both mRNA and protein levels by Real Time PCR and Western blotting techniques, respectively
Study NCT06678906 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Intervention arm
Description: All patients in the intervention group will benefit from the standard information phase on physical activity and sedentary behavior, as well as personalized support for behavior change in the form of a serious game and remote coaching.
Study NCT06616441 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Bupivacaine
Description: Group (A) only will receive intra-peritoneal 40 ml bupivacaine 0.2%, after laparoscopic procedure before removing trocars.
Study NCT06678126 — intervention group
Intervention type: RADIATION
Group type: ACTIVE_COMPARATOR
Intervention: Prostate and Pelvic Nodes Radiotherapy
Description: 60 Gy prostate and 44 Gy pelvic nodes with 20 fractions
Study NCT06678113 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: BSG005
Description: Single arm dose escalation in patients with invasive fungal infection
Study NCT06678074 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Atibuclimab (IC14), 20 mg/kg intravenously, once
Description: monoclonal antibody against CD14
Study NCT06678074 — intervention group
Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Placebo, 150 mL intravenously, once
Description: sterile normal saline for injection
Study NCT06643468 — intervention group
Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: participants will receive immediate implant with nano-crystalline putty hydroxyapatite as bone graft and ALB- PRF as membrane.
Description: 1. Injection of local anesthetic Articaine hydrochloride 4% with Epinephrine (1:100,000).~2. Atraumatic removal of remaining root or tooth then implant will be placed according to the standard protocol.~3. Sulcular incision with be made 15c blade without vertical releasing incision.~4. Implant placement with copious irrigation.~5. Membranes placement: ALB-PRF followed by insertion of nano-crystalline putty hydroxyapatite..~6. Customized healing abutment application.~7. Suturing of wound edges with 0.5 suture around the customized healing abutment.
Study NCT06643468 — intervention group
Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: participants will receive immediate implant with beta-tricalcium phosphate + calcium sulphate bone graft and collagen membrane.
Description: 1. Injection of local anesthetic Articaine hydrochloride 4% with Epinephrine (1:100,000).~2. Atraumatic removal of remaining root or tooth then implant will be placed according to the standard protocol.~3. Sulcular incision with be made 15c blade .~4. Implant placement with copious irrigation.~5. Membranes placement: collagen followed by insertion of eta-tricalcium phosphate + calcium sulphate bone graft.~6. Customized healing abutment application.~7. Suturing of wound edges with 0.5 suture around the customized healing abutment.
Study NCT06643468 — intervention group
Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: participants will receive immediate implant with beta-tricalcium phosphate + calcium sulphate bone graft and ALB-PRF membrane.
Description: 1. Injection of local anesthetic Articaine hydrochloride 4% with Epinephrine (1:100,000).~2. Atraumatic removal of remaining root or tooth then implant will be placed according to the standard protocol.~3. Sulcular incision with be made 15c blade .~4. Implant placement with copious irrigation.~5. Membranes placement: ALB-PRF followed by insertion of eta-tricalcium phosphate + calcium sulphate bone graft.~6. Customized healing abutment application.~7. Suturing of wound edges with 0.5 suture around the customized healing
Study NCT06644339 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Voice assistant
Description: Robotic remote monitoring of patients using unique algorithms developed for virtual operator speech technology and a BI system by voice commands on the question-answer principle. It allows us to automate data collection and obtain information about the patient's well-being and his vital signs (blood pressure, heart rate, weight) depending on disease.~Follow-up and management of disease provided by specialists at participating institutions.
Study NCT06643442 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Empagliflozin Tablets
Description: Empagliflozin 10mg p.o. once daily (commercially available tablet)
Study NCT06643559 — intervention group
Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: cognitive rehabilitation
Description: Cognitive rehabilitation started to one group at the beginning of the antiseizure medicine. Participants underwent computer-based cognitive rehabilitation for 3 sessions per week, with each session lasting an average of 60 minutes. Before the sessions, all participants were given detailed information about the programme and its use. The rehabilitation process was carried out in three areas of cognitive functions: memory, executive functions, and language skills.
Study NCT06644872 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Bedrest
Description: Investigation of the effect of short-term bed rest (3 hours) on heart function, measured by cardiac magnetic resonance, in healthy participants ( males and females)
Study NCT06644859 — intervention group
Intervention type: DEVICE
Intervention: Daily Activity Patterns Using Wearable Tri-Axial Sensors
Description: This intervention uniquely focuses on the prediction of injurious falls by combining daily life gait (DLG) measures (e.g., gait speed, cadence, variability) with daily life physical activity (DLPA) measures (e.g., activity levels, activity fragmentation). Unlike other studies, this analysis leverages data from a large cohort of older women (n=17,466) enrolled in the Women's Health Study (WHS), where participants wore a tri-axial accelerometer for 1 week. Additionally, the study links accelerometer data to long-term health outcomes, specifically fall-related injuries from Centers for Medicare \&amp; Medicaid Services (CMS) records. This is the first study to explore whether combining DLG and DLPA measures, derived from wearable technology, can predict fall-related injuries in an aging population, applying advanced machine learning techniques to this large, anonymized dataset.
Study NCT06684431 — intervention group
Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: N-pVAX1
Description: Crimean Congo Hemorrhagic Fever Vaccine
Study NCT04560439 — intervention group
Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Dietary Intervention
Description: Undergo METFIT program
Study NCT06693128 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Camrelizumab
Description: Camrelizumab 200mg
Study NCT04846101 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: OMNISHADE
Description: Anterior dental cavities (Class III, Class IV) will be restored with an omnishade composite material
Study NCT04846101 — intervention group
Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: MULTISHADE
Description: Anterior dental cavities (Class III, Class IV) will be restored with conventional multishade composite material.
Study NCT05762731 — intervention group
Intervention type: DIAGNOSTIC_TEST
Intervention: Low dose CT thorax
Description: A multi-detector row CT scanner with minimum section collimation of ≤1 mm and minimum number of data acquisition channels ≥ 16will be employed.
Study NCT04846101 — intervention group
Intervention type: DIAGNOSTIC_TEST
Group type: ACTIVE_COMPARATOR
Intervention: Instrumental Shade Analysis
Description: Assessment will be performed by single operator using spectrophotometer (EASYSHADE) to detect color difference between tooth and restoration
Study NCT04846101 — intervention group
Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Instrumental Shade Analysis
Description: Assessment will be performed by single operator using spectrophotometer (EASYSHADE) to detect color difference between tooth and restoration
Study NCT04846101 — intervention group
Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Visual Shade Analysis
Description: Visual assessment will be performed by two calibrated specialists to evaluate shade matching between the tooth and restoration
Study NCT04846101 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Visual Shade Analysis
Description: Visual assessment will be performed by two calibrated specialists to evaluate shade matching between the tooth and restoration
Study NCT04846101 — intervention group
Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Patient satisfaction
Description: Patient satisfaction of the final shade match will be assessed on a visual analogue scale
Study NCT05762731 — intervention group
Intervention type: DIAGNOSTIC_TEST
Intervention: Low dose CT thorax
Description: Control subjects will also proceed to CT thorax, and outcome measures be compared to subjects
Study NCT05534048 — intervention group
Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: PTX-COVID19-B
Description: The vaccine product, PTX-COVID19-B, is a preservative-free, sterile mRNA-lipid nanoparticle (mRNA-LNP) dispersion in an aqueous cryoprotectant buffer intended for IM injection.
Study NCT05534048 — intervention group
Intervention type: BIOLOGICAL
Group type: ACTIVE_COMPARATOR
Intervention: Comirnaty®
Description: 0.45 mL concentrate in a 2 mL clear multidose vial (type I glass) with a stopper (synthetic Bromo-butyl rubber) and a purple flip-off plastic cap with aluminum seal. Each vial contains 6 doses.
Study NCT06371352 — intervention group
Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: iTBS
Description: Active iTBS over the left DLPFC to induce the long term potentiation of stimulated area.
Study NCT06371352 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: cTBS
Description: Active cTBS over the right DLPFC to induce the long term potentiation of stimulated area.
Study NCT04846101 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Patient satisfaction
Description: Patient satisfaction of the final shade match will be assessed on a visual analogue scale
Study NCT05826431 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Cubii elliptical
Description: Low impact, portable, and compact elliptical for seated use.
Study NCT06298188 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Risankizumab
Description: Risankizumab
Study NCT05848440 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: AZD9550
Description: Participants will be administered AZD9550 subcutaneously.