AIM-Harvard/TrialPanorama-filtered huggingface dataset:
Study NCT05885256 — intervention group
Intervention type: DIAGNOSTIC_TEST
Intervention: Amending current standard trauma order set
Description: Blood draw happens as part of routine clinical care for all trauma activations. As part of the study, we will use existing blood that is drawn as part of routine clinical care, or when necessary, draw additional blood to obtain samples at 0, 3, 6, 12, 18, and 24 hours assessing ionized calcium, serum calcium, and magnesium. We will strive to have draws occur within +/- 1 hour of the goal times. However, given that the blood draws will be performed by way of the clinical team and the unpredictable nature of trauma care, missed draws or draws out of the goal time frame will not be considered protocol violations
Study NCT05107401 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Digital Crowdsourced Intervention to Reduce HIV Stigma among Adolescents and Young Adults
Description: Adolescents and young adults will participate in a crowdsourcing contest to create digital materials to reduce HIV stigma in order to increase HIV testing. Entries will be judged by a community judging panel and expert judging panel. Winning entries will be selected for the digital intervention and presented to participants in the intervention arm.
Study NCT05582837 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: nortriptyline + topiramate
Description: nortriptyline (7.5mg) + topiramate (10mg) taken 1x per day and escalate weekly as needed for 8 weeks
Study NCT06480643 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: High load exercise type
Description: Heavier load, fewer reps
Study NCT06480643 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Low load exercise type
Description: Lighter load, more reps
Study NCT05582837 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: nortriptyline + topiramate
Description: nortriptyline (7.5mg) + topiramate (10mg) taken 1x per day and escalate weekly as needed for 8 weeks
Study NCT05777525 — intervention group
Intervention type: COMBINATION_PRODUCT
Group type: EXPERIMENTAL
Intervention: application of cream La Chinata
Description: application of cream enriched with essential oil
Study NCT05723614 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: TRUE HAVEN
Description: The two components of the TRUE HAVEN intervention are: housing support for recently incarcerated people as well as family members of currently incarcerated people, and mental wellness training for neighborhood residents to participate in trauma-informed care training sessions.
Study NCT05508971 — intervention group
Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: DISE-Directed Surgery
Description: Participants randomized to DISE-directed surgery will undergo one or more potential procedures in a single surgery (i.e. DISE and subsequent sleep surgery performed) concurrently under the same general anesthetic), depending on anatomic assessment.
Study NCT05508971 — intervention group
Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Adenotonsillectomy
Description: Tonsil and adenoid removal
Study NCT06117995 — intervention group
Intervention type: OTHER
Intervention: Assessment the pre-washed sperm motility before IUI
Description: The pre-washed sperm motility will be assessed by using WHO 2021 guidelines, stratified into four groups.
Study NCT06572930 — intervention group
Intervention type: DRUG
Intervention: Gonal-f (gonadotropin)
Description: Women will be given 300 IU Gonal-F daily from cycle day 2 or 3. Gonal F will be injected at 8 pm daily. They will all receive cetrorelix acetate 250 mcg/day (Cetrotide) subcutaneously from stimulation day 5 onwards until and including the trigger day. Cetrotide will be administered at 08:00 am.
Study NCT05864716 — intervention group
Intervention type: BIOLOGICAL
Group type: ACTIVE_COMPARATOR
Intervention: Colonscopic probiotics spray
Description: 20g of multi-strain probiotics powder via colonoscopic spray. The probiotic used in this study is SynPro-15G, which has 15 probiotics, including Bacillus coagulans BC1031, Bifidobacterium bifidum BB14, Bifidobacterium breve BR18, Bifidobacterium animalis subsp. lactis BAL06, Bifidobacterium longum (B. longum) BL986, Lactobacillus acidophilus LA1063, Lactobacillus casei LC122, Lactobacillus delbrueckii subsp. lactis LDL114, Lactobacillus fermentum LF26, Lactobacillus helveticus LH43, Lactobacillus paracasei LPC12, Lactobacillus plantarum LP198, Lactobacillus reuteri LR21, Lactobacillus rhamnosus LRH10, and Streptococcus thermophilus ST37 at a concentration of 2x1010 CFU/g (Synbiotech Corp., Kaohsiung, Taiwan). SynPro-15G is made either as a vial of powder (2x1011 CFU /vial) for colonoscopic spray or as a capsule (2x1010 CFU/capsule) for oral intake.
Study NCT05864716 — intervention group
Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Colonscopic probiotics spray
Description: 20g of multi-strain probiotics powder via colonoscopic spray. The probiotic used in this study is SynPro-15G, which has 15 probiotics, including Bacillus coagulans BC1031, Bifidobacterium bifidum BB14, Bifidobacterium breve BR18, Bifidobacterium animalis subsp. lactis BAL06, Bifidobacterium longum (B. longum) BL986, Lactobacillus acidophilus LA1063, Lactobacillus casei LC122, Lactobacillus delbrueckii subsp. lactis LDL114, Lactobacillus fermentum LF26, Lactobacillus helveticus LH43, Lactobacillus paracasei LPC12, Lactobacillus plantarum LP198, Lactobacillus reuteri LR21, Lactobacillus rhamnosus LRH10, and Streptococcus thermophilus ST37 at a concentration of 2x1010 CFU/g (Synbiotech Corp., Kaohsiung, Taiwan). SynPro-15G is made either as a vial of powder (2x1011 CFU /vial) for colonoscopic spray or as a capsule (2x1010 CFU/capsule) for oral intake.
Study NCT05449067 — intervention group
Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Group A and Group B
Description: Group A: Participants receive APD for 12 weeks then switch to CAPD for another 12 weeks; Group B: Participants receive CAPD for 12 weeks and switch to APD for another 12 weeks.
Study NCT05449067 — intervention group
Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Group A and Group B
Description: Group A: Participants receive APD for 12 weeks then switch to CAPD for another 12 weeks; Group B: Participants receive CAPD for 12 weeks and switch to APD for another 12 weeks.
Study NCT06658756 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: internet-CBT
Description: 10 modules on line of I-CBT for OCD
Study NCT06297213 — intervention group
Intervention type: DRUG
Group type: OTHER
Intervention: R-2487
Description: R-2487 DP
Study NCT05530707 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Moisturizer containing saccharide isomerate and niacinamide
Description: Moisturizer containing saccharide isomerate and niacinamide
Study NCT05238220 — intervention group
Intervention type: DRUG
Intervention: Valganciclovir
Description: continuation of valganciclovir prophylaxis up to 12 months with absence of demonstrated anti-CMV immunity
Study NCT04278729 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Apixaban 5 MG
Description: 1 - 5 mg tablet taken orally twice a day
Study NCT06570213 — intervention group
Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Cognitive Processing Therapy
Description: Cognitive Processing Therapy is a first-line, gold-standard psychotherapy intervention for the treatment of PTSD.
Study NCT06570213 — intervention group
Intervention type: BEHAVIORAL
Group type: SHAM_COMPARATOR
Intervention: Cognitive Processing Therapy
Description: Cognitive Processing Therapy is a first-line, gold-standard psychotherapy intervention for the treatment of PTSD.
Study NCT06570213 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Stellate Ganglion Block
Description: Stellate Ganglion Blocks are an injection of local anesthetic into the stellate ganglion, a collection of nerves in the side of the neck.
Study NCT06570213 — intervention group
Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Stellate Ganglion Block
Description: Stellate Ganglion Blocks are an injection of local anesthetic into the stellate ganglion, a collection of nerves in the side of the neck.
Study NCT05031455 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Aspirin Challenge
Description: Dupilumab is a fully human monoclonal antibody that blocks the receptor component for IL-4 and IL-13, which are key drivers of type 2 inflammation. All subjects will be prescribed this at standard 300mg subcutaneous dosing every 2 weeks. The intervention will be the response to aspirin challenge.~All 16 subjects will receive dupilumab. All subjects will undergo an aspirin challenge/desensitization procedure. It is estimated that 50% of subjects will have a respiratory reaction to aspirin and 50% will not. There will not be any randomization.
Study NCT06054633 — intervention group
Intervention type: DIETARY_SUPPLEMENT
Group type: ACTIVE_COMPARATOR
Intervention: L-arginine tablet
Description: L-arginine, 2 g, three times daily, for 12 weeks
Study NCT06054633 — intervention group
Intervention type: DIETARY_SUPPLEMENT
Group type: PLACEBO_COMPARATOR
Intervention: Placebo tablet
Description: Identical inert placebo, three times daily, for 12 weeks
Study NCT05843773 — intervention group
Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Low Load Strength Training under Blood Flow Restriction
Description: The first training includes one initiation/warm up set and two sets of normal training. Every set lasts 60 seconds and the patient is asked to bend and stretch the knee with a standard speed of 20°/s.~From the second to the ninth training, the patient will have one warm up set plus three trainings sets. The speed of execution will be increased every training.~The 20-40% range of the 1RM will be applied according to the values of the theoretical maximal strength.~If no strength progression is observed in the three last training sessions, the speed of execution will automatically be increased by 15°/s.~In order to keep the training intensity low and to not overload the knee, participants will be instructed to control the intensity with the Borg CR10. The volunteers will have to keep their efforts between 2/10 and 4/10. They will also be asked to stay in the range defined thanks to the theoretical maximal strength shown by the screen.
Study NCT04563481 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Hand Therapy via Telerehabilitation
Description: stretching exercises; all finger joints, wrist and supination-pronation direction strengthening exercises; finger and wrist functional exercises retrograde massage; starting from the distal phalanx to the elbow sensory education; desentilation training (cotton...) breathing exercises 5 days / week, 8 weeks in total~* 3 days / week with physiotherapist~* 2 days / week as home program 30 minutes / day 12 repetitions
Study NCT04563481 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Hand Therapy by Physiotherapist
Description: stretching exercises; all finger joints, wrist and supination-pronation direction strengthening exercises; finger and wrist functional exercises retrograde massage; starting from the distal phalanx to the elbow sensory education; desentilation training (cotton...) breathing exercises 5 days / week, 8 weeks in total~* 3 days / week with physiotherapist~* 2 days / week as home program 30 minutes / day 12 repetitions
Study NCT06052839 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Pembrolizumab
Description: Immunotherapy that works by helping the immune system to kill cancer cells by targeting and blocking a protein called PD-1 on the surface of certain immune cells called T-cells. Blocking PD-1 triggers the T-cells to find and kill cancer cells.
Study NCT06052839 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Carboplatin
Description: A chemotherapy drug that contains the metal platinum. It stops or slows the growth of cancer cells and other rapidly growing cells by damaging their DNA.
Study NCT06052839 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Paclitaxel
Description: A chemotherapeutic agent used as a treatment for various cancers; paclitaxel is a mitotic inhibitor.
Study NCT06674785 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: focused extracorporeal shock wave therapy (ESWT)
Description: The focused shockwaves are directed at the affected muscles in the upper limb, specifically targeting the subscapularis, pectoralis major, latissimus dorsi, and teres major muscles.
Study NCT06674785 — intervention group
Intervention type: DEVICE
Group type: PLACEBO_COMPARATOR
Intervention: focused extracorporeal shock wave therapy (ESWT)
Description: Placebo shockwave therapy directed at subscapularis, pectoralis major, latissimus dorsi, and teres major muscles.
Study NCT05627492 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Dialectical behavioral therapy
Description: DBT will be conducted over 2 years. Participants and their treatment providers will decide on the frequency of sessions collaboratively. This may include individual and/or skills sessions in addition to phone coaching for those who attend individual sessions at least once per month. DBT consultation will also remain a component of the treatment. Participants may choose skills training, conducted in approximately 60 minute meetings, and individual therapy conducted in approximately 60 minute sessions. Family participation in skills training is highly encouraged. Skills training may include: psychoeducation, mindfulness skills, emotion regulation skills, distress tolerance skills, interpersonal skills, and walking the middle path skills. Individual therapy sessions aim to aid the youth in applying skills in their daily lives. We adopt the standard DBT hierarchy of treatment targets.
Study NCT05414747 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: ABV-1701
Description: ABV-1701 is an injectable, in-situ-forming hydrogel, composed of oxidized hyaluronic acid (oxi-HA) and adipic acid dihydrazide (ADH)
Study NCT05414747 — intervention group
Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: SF6 Gas
Description: SF6 is a commercial gas tamponade as a vitreous substitute in pars-plana vitrectomy surgery (PPV)
Study NCT05743140 — intervention group
Intervention type: DIAGNOSTIC_TEST
Intervention: CaIMR
Description: Investigators diagnose CMD with CaIMR. Investigators use OCT and OCTA to analyze the fundus microcirculation quantitatively.
Study NCT06690931 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Brain-Computer Interface with FES and VR
Description: The intervention utilizes the recoveriX PRO system. This is a neurofeedback therapy device that combines Brain-Computer Interface based motor imagery, functional electrical stimulation (FES), and virtual reality (VR). This approach enables participants to engage in motor imagery exercises while receiving real-time feedback based on neural signals.~Participants will complete a total of 24 recoveriX sessions, scheduled at 6 sessions per week, with each session lasting 1 hour.
Study NCT06690931 — intervention group
Intervention type: DEVICE
Group type: SHAM_COMPARATOR
Intervention: Motor imagery with Functional Electrical Stimulation and Virtual Reality feedback
Description: The participants will train the Motor Imagination (MI) combined with Functional Electrical Stimulation (FES) and Virtual Reality (VR) feedback. Feedback provided to the patients will not be linked to the neural signals.~The amount of stimulation delivered by the feedback devices (FES and VR) will be similar to the experimental group.
Study NCT06689982 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Tofacitinib tablets
Description: All patients should be closely monitored for signs and symptoms of infection during and after treatment with tofacitinib tablets. If a patient develops a severe infection, opportunistic infection, or sepsis, medication should be discontinued. During treatment, patients with lymphocyte counts \< 500 cells/mm\^3 or ANC \< 500 cells/mm\^3 confirmed by repeated testing should be stopped. When 500≤ANC≤1000 cells/mm\^3, administration should be interrupted, and if ANC returns to more than 1000 cells/mm\^3, administration should be resumed. When hemoglobin \< 8 g/dL or decreases by more than 2 g/dL, administration should be interrupted until hemoglobin values return to normal.
Study NCT06689137 — intervention group
Intervention type: OTHER
Intervention: mini mental state assessment test
Description: Anesthesia management during surgery for this disease in the postoperative period should be carefully planned. It will be important to examine the neurocognitive effects of anesthesia management in the postoperative period in this patient group. In this study, the frequently used Mini mental state assessment test and Mini-cog test will be used. With mini mental state assessment, the patient is asked a number of simple questions to evaluate cognitive functions and each question has certain points. Changes in these score levels preoperatively and postoperatively will be compared within each patient. At the end of the study, preoperative and postoperative changes will be compared statistically between the groups.
Study NCT04946110 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Electromagnetic stimulation
Description: Electromagnetic stimulation of the phrenic nerve
Study NCT05782439 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Manual evaluation of ITB tension
Description: There will be a double evaluation for each sampling session: 1) if there is a uniformity of the tension between the two sides, or if there is a prevalence on one side; 2) quantification of the difference, if present, with a graduation in 3 levels.
Study NCT06254560 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Rituximab
Description: Rituximab is administered at a dose of 100mg per week, a total of 4 times. Cyclosporin is administered at a dose of 3-5mg/kg per day.
Study NCT06689137 — intervention group
Intervention type: OTHER
Intervention: mini-cog test
Description: Anesthesia management during surgery for this disease in the postoperative period should be carefully planned. It will be important to examine the neurocognitive effects of anesthesia management in the postoperative period in this patient group. In this study, the frequently used Mini mental state assessment test and Mini-cog test will be used.With Mini-cog test, the patient is asked a number of simple questions to evaluate cognitive functions and each question has certain points. Changes in these score levels preoperatively and postoperatively will be compared within each patient. At the end of the study, preoperative and postoperative changes will be compared statistically between the groups.
Study NCT06020430 — intervention group
Intervention type: RADIATION
Group type: ACTIVE_COMPARATOR
Intervention: CTV omitted or delineated
Description: Patients who responded to the induction therapy (immunotherapy and chemotherapy) were randomly (1:1) assigned into CTV-omitted radical radiotherapy group or CTV-delineated radiotherapy group.
Study NCT06020430 — intervention group
Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: CTV omitted or delineated
Description: Patients who responded to the induction therapy (immunotherapy and chemotherapy) were randomly (1:1) assigned into CTV-omitted radical radiotherapy group or CTV-delineated radiotherapy group.
Study NCT06681727 — intervention group
Intervention type: OTHER
Intervention: Accessible Video Mental Healthcare Triage and Assessment (IP)
Description: Patients aged 18 years and older who were registered at participating primary care centers were eligible to access the IP through a regional healthcare app. IP comprised a brief digital screening followed by a 45-minute video consultation with a mental health professional. Eligible patients could thereafter schedule appointments at cooperating healthcare centers and clinics through the app used for video consultations.
Study NCT05116072 — intervention group
Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: total pancreatectomy
Description: The total pancreatectomy will be performed in two steps: The pancreatectomy will begin by a standard pancreaticoduodenectomy procedure.~The section margin will be sent for intraoperative histological analysis to confirm the absence of invasion of the left remnant pancreas.~When absence of tumor invasion is confirmed and the high-risk of postoperative pancreatic fistula is validated intraoperatively, the extended left distal pancreatectomy will be performed, with splenic preservation when possible.~Then, the left side of the pancreas will be resected and cooled (4-6°) in the preservation solution and shipped to Lille Biotherapy platform to perform islet isolation and purification. The reconstruction after total pancreatectomy will be done as usually performed by center expert surgeon.
Study NCT05116072 — intervention group
Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: intraportal islet autotransplantation
Description: The final islet preparation will be cultured and shipped 48 hours after total pancreatectomy from the Lille laboratory to the surgical center, and finally transplanted into the patient through a venous catheter placed in the portal trunk (91% of the total islet mass) and at the same time, a small fraction of the isolated islet (5% of the total islet mass) will be transplanted into the forearm muscle.
Study NCT06694298 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: SYS6020
Description: BCMA Chimeric Antigen Receptor T Cell（SYS6020）Injection Intravenous infusion
Study NCT06688591 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Intervention programme to optimise medication management and prevent MRPs
Description: The intervention is based on a four-step patient empowerment process: 1) the patient understands their role; 2) the patient acquires sufficient knowledge to be able to engage with their healthcare professionals; 3) the patient improves their skills; and 4) there is a facilitating environment (30). Each older adult participant's plan will be unique and consider their preferences, medication literacy and treatment adherence.
Study NCT06378502 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Amoxicillin Short
Description: Short Span
Study NCT06378502 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Amoxicillin Long
Description: Long span
Study NCT06694818 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: trauma film paradigm
Description: Use the trauma films as stressors to induce stress and evaluate how it affects sleep reactivity in healthy subjects with insomnia symptoms compared to healthy subjects without insomnia symptoms
Study NCT06022588 — intervention group
Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Sodium butyrate, 1-13C, 99%, Cambridge Isotope Laboratories, Inc.USA
Description: a solution containing butyrate of which 12C of the last 4 carbon positions of butyrate were replaced by 13C butyrate. Participants received 0.80 gram 13C-butyrate (7.3 mMol butyrate / 29 mMol 13C) dissolved in 50 mL water at baseline