AIM-Harvard/TrialPanorama-filtered huggingface dataset:
Study NCT05658692 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: prone position ventilation
Description: patients with moderate to severe ARDS who don't have contraindications were given prone ventilation for over 12 hours.
Study NCT05658692 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: glucocorticoid therapy
Description: Dexamethasone: Patients received intravenous dexamethasone 20 mg daily from days 1 to 5, reduced to 10 mg daily from days 6 to 10.~Hydrocortisone：For septic ARDS patients, 50 mg of hydrocortisone was given as an intravenous bolus every 6 hours for 7 days; For patients with COVID-19-related ARDS, The corticosteroid field randomized participants to a fixed 7-day period of intravenous hydrocortisone (50 mg or 100 mg every 6 hours).
Study NCT05658692 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: restrictive fluid resuscitation
Description: 1. without other organ dysfunction patients: Minimize fluid was given;~2. other ARDS patients: In the resuscitation phase, controlled fluid replacement combined with vasoactive drugs was given; multiple measures were taken, like lactate and so on, to utilizedto guide fluid resuscitation therapy; diuretics or diuretics in combination with albumin to achieve fluid balance.
Study NCT05658692 — intervention group
Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Thymosin Alpha
Description: People received thymosin Alpha subcutaneous injections, twice a week.
Study NCT05658692 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Muscle relaxant therapy
Description: Deep sedation combined with intermittent bolus injection of muscle relaxant or deep sedation combined with continuous infusion of muscle relaxant
Study NCT05658692 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Integrated Chinese and Western Medicine Treatment
Description: 1. ventilation;~2. conventional western medicine treatment；~3. Chinese herbal medicine（Determining medication based on syndrome differentiation）
Study NCT05658692 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: statin therapy
Description: 1. Simvastatin: 80mg qd po for not more than 28days;~2. Rosuvastatin: 20mg qd po (40mg for the first time) for 28days or 3 days after transfer out of the ICU, or the patient died.
Study NCT05658692 — intervention group
Intervention type: COMBINATION_PRODUCT
Group type: EXPERIMENTAL
Intervention: anti-infective treatment
Description: According to Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021.
Study NCT05658692 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Extracorporeal Membrane Oxygenation（ECMO）
Description: 1. For severe ARDS patients with refractory hypoxemia within 7 days of onset;~2. (Inspiratory oxygen concentration) ≥ 0.80, tidal volume 6ml/kg (PBW), positive end-expiratory pressure \[PEEP\] ≥ 10 cmH2O;~3. V-V Model.
Study NCT05658692 — intervention group
Intervention type: GENETIC
Group type: EXPERIMENTAL
Intervention: stem cell therapy
Description: A single injection of bone marrow stem cells, doses of 1, 5, 10\*106 cells/kg was taken according to the previous clinical studies.
Study NCT06133907 — intervention group
Intervention type: GENETIC
Group type: EXPERIMENTAL
Intervention: Serum
Description: Patients who came to the pneumoallergology department of the CHU de Nice since January 2014 for an allergological workup and with tryptasemia was ≥ 8ng/ml (at least once in patient history).
Study NCT05658692 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Sedative analgesia/muscle relaxant therapy
Description: Deep sedation combined with intermittent bolus injection of muscle relaxant or deep sedation combined with continuous infusion of muscle relaxant
Study NCT05658692 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: inotropes therapy
Description: According to Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021.
Study NCT05110144 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Duloxetine 30 MG
Description: 30mg orally for 4 weeks
Study NCT05110144 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Duloxetine 60 MG
Description: 60mg orally for 4 weeks
Study NCT05110144 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Amitriptyline 25 MG
Description: 25 mg orally for 4 weeks
Study NCT05110144 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Amitriptyline 50 MG
Description: 50 mg orally for 4 weeks
Study NCT05110144 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo 30 MG
Description: 30mg tablet with no active study ingredient for 4 weeks
Study NCT05110144 — intervention group
Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo 30 MG
Description: 30mg tablet with no active study ingredient for 4 weeks
Study NCT05110144 — intervention group
Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo 60 MG
Description: 60mg tablet with no active study ingredient for 4 weeks
Study NCT06419855 — intervention group
Intervention type: DEVICE
Intervention: Human collagen matrix graft
Description: Is a porous cross-linked human collagen Matrix or Sponge, used as a scaffold in the repair and restoration of dura mater defects, following craniotomy, laminectomy or in general when there is intentional (surgical procedure) or accidental damage to the dura mater.
Study NCT06419855 — intervention group
Intervention type: DEVICE
Intervention: Bovine collagen matrix graft
Description: Is a porous type 1 collagen matrix derived from bovine Achilles tendon, this matrix is absorbed after 8 weeks and is used for the repair and restoration of dura mater defects.
Study NCT05658692 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Vasoactive drug therapy
Description: According to Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021.
Study NCT05576285 — intervention group
Intervention type: DIAGNOSTIC_TEST
Intervention: ophthalmoscopy and fundus photography through dilated pupills
Description: ophthalmoscopy and fundus photography through dilated pupills
Study NCT04776629 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Orticumab
Description: A human recombinant monoclonal antibody against a specific oxidized low-density lipoprotein (oxLDL) epitope
Study NCT04776629 — intervention group
Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Placebo for orticumab, containing all components of formulation except the active ingredient
Study NCT05382208 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Doxycycline
Description: Doxycycline 100 mg orally twice a day.
Study NCT05382208 — intervention group
Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Matching placebo orally twice a day.
Study NCT03644641 — intervention group
Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Desflurane Group
Description: General anesthesia will be held using desflurane in end- tidal concentration according to target value of entropy levels (between 40 and 60).
Study NCT03644641 — intervention group
Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Propofol Group
Description: General anesthesia will be held using Schnider effect model for propofol (target control anesthesia). Titration will be done according to target value of entropy levels (between 40 and 60).
Study NCT06347224 — intervention group
Intervention type: PROCEDURE
Group type: OTHER
Intervention: Virtual placement of lag screws in both columns of the acetabulum on 3D pelvic CT models.
Description: The intervention aims to simulate a percutaneous fixation technique that could be applied in a real surgical environment, offering insights into the potential for personalized surgical planning and optimization of outcomes for patients with acetabular fractures. This virtual approach allows for the exploration of various screw placement strategies without the ethical and practical constraints of direct clinical experimentation.
Study NCT05349890 — intervention group
Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: TCR-transduced T cells
Description: TSA-reactive TCR-engineered T cells
Study NCT05349890 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: CDX-1140
Description: Recombinant fully human IgG2κ monoclonal antibody
Study NCT05349890 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Pembrolizumab
Description: Humanized immunoglobulin G4 (IgG4) monoclonal antibody
Study NCT05290259 — intervention group
Intervention type: OTHER
Intervention: Ballroom Dance
Description: The Ballroom Basics for Balance Program is a dance focused exercise program developed by a Physical Therapist in the Madison area.
Study NCT05156723 — intervention group
Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Subunit recombinant vaccine for the prevention of coronavirus infection
Description: solution for intramuscular injection, 0.5 ml
Study NCT05156723 — intervention group
Intervention type: BIOLOGICAL
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: solution for intramuscular injection, 0.5 ml
Study NCT06416215 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Psychological intervention based on WBT and cognitive restructuring
Description: Participants will engage in 6 weekly group session of two hours. One part will be held by a trained dietician and will focus on nutritional education, particularly emphasizing the adoption of healthy and sustainable eating behaviors. The remaining part will be dedicated to a group psychological intervention inspired by the principles of Well-Being Therapy and will be held by a trained psychologist. During these sessions, participants will be introduced to the six dimensions of psychological well-being and will be gradually provided with cognitive-behavioral strategies to enhance psychological well-being and seek a balance between the presented dimensions. Participants will be given cognitive-behavioral tools to recognize justification cognitive mechanisms and replace them with more functional cognitions. These objectives will also be achieved through the use of a food diary to highlight emotions and thoughts experienced during food intake.
Study NCT06416215 — intervention group
Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Basic Nutritional Intervention
Description: Participants will receive treatment as usual (TAU) by participating in 6 weekly group sessions of two hours of a Basic Nutritional Intervention (BNI) held by a trained dietician. This course focuses on promoting healthier lifestyles through nutritional education, diet monitoring using a dedicated food diary, and recommendations for proper physical activity.
Study NCT06461234 — intervention group
Intervention type: BEHAVIORAL
Intervention: Pelvic floor muscle training
Description: A therapist will instruct the patient to contract the anus, perineum as well as the urethra, until the patient masters the correct method.
Study NCT06461234 — intervention group
Intervention type: OTHER
Intervention: Biofeedback electrical stimulation
Description: The therapist will place the electrodes of the instrument into the vagina, adjust the current value until the woman feels obvious contraction of the pelvic floor muscles but no pain, and instructs the patient to refer to the biofeedback mode for vaginal and anal contraction and relaxation.
Study NCT06461234 — intervention group
Intervention type: OTHER
Intervention: Magnetic Stimulation
Description: The therapist will use the magnetic stimulator to intermittently stimulate the and adjust the stimulation intensity at any time according to the patient\&amp;amp;amp;#39;s condition, adjusting it until there is a clear sense of contraction and feel comfortable.
Study NCT06461234 — intervention group
Intervention type: OTHER
Intervention: Magnetic stimulation combined with biofeedback electrical stimulation
Description: Pelvic floor magnetic stimulation for 30 minutes followed by biofeedback electrical stimulation.
Study NCT06160674 — intervention group
Intervention type: OTHER
Intervention: COPD
Description: A vowel segmentation data set consisting of information from COPD and HC groups will be used to experiment with the classification performance of several Machine Learning techniques on different segments of a vowel recording.
Study NCT05576597 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Sodium Butyrate
Description: 2 capsules butyrate supplement once a day for 12 weeks
Study NCT06232707 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Alnuctamab
Description: Specified dose on specified days
Study NCT06232707 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Pomalidomide
Description: Specified dose on specified days
Study NCT06232707 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Daratumumab
Description: Specified dose on specified days
Study NCT06232707 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Elotuzumab
Description: Specified dose on specified days
Study NCT06232707 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Carfilzomib
Description: Specified dose on specified days
Study NCT06232707 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Dexamethasone
Description: Specified dose on specified days
Study NCT05359380 — intervention group
Intervention type: OTHER
Intervention: ADL performance
Description: ADL performance~All study groups address the following 10 ADL tasks in 9 different combinations of light temperature and light intensity in order possible differences to be revealed among the study groups and light combinations:~1. Phone Book Search (PBS), 2. Supermarket receipt (SupRe), 3. Book reading (BR), 4. Cellular message (CM), 5. Cellular entry search (CES), 6. Reading computer screen (RCS), 7. Drops bottle reading (DR), 8. Subtitles reading (SubRe), 9. Open door test (ODT), and, 10. Screwdriver test (ST).~The 9 light combinations are the following:~3000 K - 25 fc, 3000 K - 50 fc, 3000 K - 75 fc / 4000 K - 25 fc, 4000 K - 50 fc, 4000 K - 75 fc / 6000 K - 25 fc, 6000 K - 50 fc, 6000 K - 75 fc
Study NCT05204888 — intervention group
Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: myAirvo3
Description: For patients assigned to the HFNT intervention group, a myAirvo 3 device will be provided. The myAirvo 3 is for the treatment of spontaneously breathing patients, infant to adult, who would benefit from receiving high flow warmed and humidified respiratory gases. This includes patients who have had upper airways bypassed. The flow may be from 2 - 60 L/min depending on the patient interface. The myAirvo 3 is for patients in homes and long-term care facilities.
Study NCT05204888 — intervention group
Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Pulse oximeter
Description: A pulse oximeter will be provided to measure heart rate and pulse oximetry; subjects will enter and transmit the data on the smartphone once daily before 11AM. Heart rate and pulse oximetry measures will be taken after wearing the device for approximately 2 minutes.
Study NCT06503523 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Hypertonic Saline
Description: A bolus injection of hypertonic saline (7% NaCl) will be administered to the FDI muscle using a 1 mL syringe with a disposable needle (27G), and the volume of the bolus will be 0.1 mL
Study NCT06503523 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Histamine
Description: A small drop of histamine dihydrochloride will be applied to a previously determined area on the volar forearm, followed by a prick through the drop
Study NCT06503523 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Cowhage
Description: This insertion is conducted by forceps using a stereomicroscope, and 30-35 spicules are gently rubbed into a 1 cm diameter skin area.
Study NCT06503523 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Transcranial magnetic stimulation (TMS)
Description: Transcranial magnetic stimulation (TMS) will be used to evoke motor-evoked potentials (MEPs) in the muscle of interest and cortical responses (TMSevoked potentials - TEPs) in the motor cortex with a figure-eight-shaped cone coil.
Study NCT06262347 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Personally-Tailored Opioid-overdose and Medication for opioid use disorder (MOUD) Education (TOME)
Description: The TOME intervention is a modified version of the personally-tailored opioid overdose prevention education and naloxone distribution (PTOEND) intervention (Winhusen et al. Evaluation of a personally-tailored opioid overdose prevention education and naloxone distribution intervention to promote harm reduction and treatment readiness in individuals actively using illicit opioids. Drug Alcohol Depend. Nov 1 2020;216:108265). Modifications include updating the knowledge assessment/education to reflect changes in the drug supply (i.e., the current high prevalence of fentanyl and increasing prevalence of xylazine) and the addition of items specific to pregnancy. Like PTOEND, TOME is a computer-guided intervention which utilizes REDCap to complete assessments and automatically generate personally-tailored feedback reports.
Study NCT06262347 — intervention group
Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Control
Description: Participants randomized to the control condition will be offered three SAMHSA handouts.
Study NCT05133843 — intervention group
Intervention type: PROCEDURE
Group type: OTHER
Intervention: Assession of complete coronary physiology
Description: Assession of complete coronary physiology in TAVI candidates with intermediate coronary artery stenosis before and 6 months after TAVI.
Study NCT04475731 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Ponatinib
Description: Ponatinib 45 mg/day x 4 weeks x 3 courses.~+/- chemotherapy:~* vincristine or~* L-VAMP (leucovorin, vincristine, aracytin, methotrexate, prednisone)
Study NCT05968300 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: INFORMED-Living Well
Description: 1) LHW outreach support providing responsive education and support; and 2) a 6-week automated SMS text messaging
Study NCT05968300 — intervention group
Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Text Messaging Only
Description: A 6-week automated SMS text messaging
Study NCT06311565 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Education
Description: Individuals in this group will be trained on acquiring healthy lifestyle behaviors to protect against colorectal cancer. Training will be individual, face-to-face and in the form of question and answer. At the end of the training, training brochures prepared by the researchers after taking expert opinions will be distributed to the participants. The training will take approximately 25-30 minutes. The training will take place in the training hall at the family health center.
Study NCT06513078 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Static cupping
Description: 4 cups were placed on the gastrocnemius, negative pressure was applied and participants lay prone on a table for 10 minutes.
Study NCT06513078 — intervention group
Intervention type: OTHER
Group type: SHAM_COMPARATOR
Intervention: Static sham cupping
Description: 4 cups were placed on the gastrocnemius, negative pressure was applied and participants lay prone on a table for 10 minutes. A pin hole in the cup allowed pressure to slowly leak out during the treatment.
Study NCT06513078 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Dynamic cupping
Description: 4 cups were placed on the gastrocnemius, negative pressure was applied and participants lay prone on a table for 5 minutes, then did ankle exercises for 3 minutes, and lastly lay prone on the table for the last 3 minutes.
Study NCT06513078 — intervention group
Intervention type: OTHER
Group type: SHAM_COMPARATOR
Intervention: Dynamic sham cupping
Description: 4 cups were placed on the gastrocnemius, negative pressure was applied and participants lay prone on a table for 5 minutes, then did ankle exercises for 3 minutes, and lastly lay prone on the table for the last 3 minutes. A pin hole in the cup allowed pressure to slowly leak out during the treatment.
Study NCT05806385 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Cryoablation
Description: Tumor ablation before neoadjuvant chemotherapy
Study NCT05806385 — intervention group
Intervention type: COMBINATION_PRODUCT
Group type: EXPERIMENTAL
Intervention: Cryoablation combined with PD1 Inhibitor
Description: Combination of cryoablation with PD1 inhibitor before neoadjuvant chemotherapy
Study NCT05788172 — intervention group
Intervention type: OTHER
Intervention: Iron isotope dilution
Description: Menstrual blood loss will be determined using the iron isotope dilution technique and compared to the amount determined via the alkaline hematin method.
Study NCT05788172 — intervention group
Intervention type: OTHER
Intervention: Alkaline hematin method
Description: Menstrual blood loss will be determined using the alkaline hematin method and compared to the amount determined via the iron isotope dilution technique.
Study NCT05946993 — intervention group
Intervention type: OTHER
Group type: OTHER
Intervention: Physiotherapy
Description: participant will have 2 x 1h exercise classes per week with a physiotherapist, who will develop individualized plans based on medical history and scan reviews. Participants will be progressively guided through the programme, incrementally increasing in intensity or with modifications based on symptomatic presentation. This will be based on their baseline strength and cardiovascular fitness testing and grounded on evidence-based protocols previously demonstrating an effect in this patient population. Individualised tailored exercise programme which includes strength and conditioning.
Study NCT05984394 — intervention group
Intervention type: DIAGNOSTIC_TEST
Intervention: BAL antigen-specific Th1 cells and Th17 cells, ILC and MAIT
Description: BAL antigen-specific Th1 cells and Th17 cells, ILC and MAIT
Study NCT06652555 — intervention group
Intervention type: OTHER
Intervention: Group 1
Description: without Intervention
Study NCT04413604 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Young children's milk (1-<3)
Description: young children's milk containing protein, energy and fat and micronutrients, in accordance with global and local nutritional recommendations for ages 1-3.
Study NCT06457204 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Pramipexole (from manufacturing site 1)
Description: Pramipexole (from manufacturing site 1) - test treatment
Study NCT06457204 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Pramipexole (from manufacturing site 2)
Description: Pramipexole (from manufacturing site 2) - reference treatment