AIM-Harvard/TrialPanorama-filtered huggingface dataset:
Study NCT05372965 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: experimental-periodontitis-mirna-223-gingival tissue-saliva samples
Description: Non-surgical periodontal treatment will be applied to individuals with periodontitis, gingival samples will be collected during the treatment, clinical measurements and saliva collection will be repeated 6 weeks after the treatment. MiRNA-223 gene expression analysis will be performed by real-time PCR (Polymerase Chain Reaction) method in saliva and gingival samples of individuals. MiRNA-223 and cotinine levels will be examined to evaluate the effects of smoking before and after treatment in periodontal health and periodontitis. Clinical measurements (Plaque index, probing depth, gingival recession, clinical attachment level, bleeding on probing) and salivary sample will be taken from all individuals at the beginning of the study.
Study NCT05372965 — intervention group
Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: control-clinical healthy mirna-223-gingival tissue-saliva samples
Description: Clinical measurements (Plaque index, probing depth, gingival recession, clinical attachment level, bleeding on probing) and salivary sample will be taken from all individuals at the beginning of the study. MiRNA-223 and cotinine levels will be examined to evaluate the effects of smoking before and after treatment in periodontal health and periodontitis. A pre-treatment saliva sample will be collected from the clinically healthy group. A tissue sample will be collected during the clinical crown lengthening operation.
Study NCT04928521 — intervention group
Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: bilateral erector spinae plane block with 30 mL 0.25 % bupivacaine
Description: Preoperative, awake, bilateral, ultrasound-guided erector spinae plane block with 30 mL 0.25 % bupivacaine
Study NCT04928521 — intervention group
Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: bilateral erector spinae plane block with 20 mL 0.25 % bupivacaine
Description: Preoperative, awake, bilateral, ultrasound-guided erector spinae plane block with 20 mL 0.25 % bupivacaine
Study NCT05349292 — intervention group
Intervention type: OTHER
Intervention: ANH
Description: one group will be managed with ANH and the other without (control group)
Study NCT06256107 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Virtual Reality Headset
Description: Virtual Reality Headset
Study NCT06249425 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Comprehensive rehabilitation therapy
Description: Including： Basic treatment, including corresponding control of risk factors and education on healthy lifestyles.~Swallowing training, including lemon ice stimulation, empty swallowing training, and pronunciation training.~Pulmonary function training, including standing training, cough training, and diaphragm muscle training.
Study NCT06249425 — intervention group
Intervention type: BEHAVIORAL
Group type: PLACEBO_COMPARATOR
Intervention: Comprehensive rehabilitation therapy
Description: Including： Basic treatment, including corresponding control of risk factors and education on healthy lifestyles.~Swallowing training, including lemon ice stimulation, empty swallowing training, and pronunciation training.~Pulmonary function training, including standing training, cough training, and diaphragm muscle training.
Study NCT06249425 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Intermittent Oro-esophageal Tube Feeding
Description: All patients are given enteral nutritional support with Intermittent Oro-esophageal Tube according to the following procedure: Before each feeding, inside and outside of the tube was cleaned with water. During feeding, the patient should maintain a semi-reclining or sitting position with mouth opened, and the tube was inserted slowly and smoothly into the upper part of the esophagus by medical staffs while the appropriate depth of intubation was checked with the calibration markings on the tube wall. The distance from the incisors to the head part of the tube should be between 22-25 cm. However, the specific depth should be evaluated based on patients' feedback and adjusted accordingly. After insertion, the tail part of the tube should be put into a container full of water and the absence of continuous bubbles indicated a successful intubation. Then, the feeding was to be conducted three times per day with 50 ml per minute and 400-600ml for each feeding.
Study NCT06249425 — intervention group
Intervention type: DEVICE
Group type: PLACEBO_COMPARATOR
Intervention: Intermittent Oro-esophageal Tube Feeding
Description: All patients are given enteral nutritional support with Intermittent Oro-esophageal Tube according to the following procedure: Before each feeding, inside and outside of the tube was cleaned with water. During feeding, the patient should maintain a semi-reclining or sitting position with mouth opened, and the tube was inserted slowly and smoothly into the upper part of the esophagus by medical staffs while the appropriate depth of intubation was checked with the calibration markings on the tube wall. The distance from the incisors to the head part of the tube should be between 22-25 cm. However, the specific depth should be evaluated based on patients' feedback and adjusted accordingly. After insertion, the tail part of the tube should be put into a container full of water and the absence of continuous bubbles indicated a successful intubation. Then, the feeding was to be conducted three times per day with 50 ml per minute and 400-600ml for each feeding.
Study NCT06249425 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Transcranial direct current stimulation
Description: In this study, transcranial direct current stimulation is performed using a battery-powered constant current stimulator. This device delivers the current through two electrodes immersed in saline solution. Specifically, a 50mm\*50mm anodal electrode pad is placed at the center of the healthy side swallowing sensory-motor cortex of the patient. According to the positioning method of the international 10-20 electrode system, the swallowing sensory-motor cortex of the left brain is located at the midpoint between C3 and T3, while that of the right brain is located at the midpoint between C4 and T4. The cathode is placed on the opposite shoulder, using a current of 1mA, once a day, for 20 minutes each time, and 5 days a week. The instruments used for placebo patients will not have any actual effect.
Study NCT05526612 — intervention group
Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Group 1 Motor imagery and Bobath Therapeutic Approach (BTA+MI)
Description: Motor imagery (MI) is the mental rehearsal of motor abilities to improve function. Without revealing any movement in the body, the representation of the movement is created in the mind, the person imagines that he/she is performing the movement. Eating activity will be applied in motor imagery. Individualized therapy sessions in the Bobath Therapeutic Approach will also be received by the Physiotherapist along with Motor imagery. 2 days a week, 30 minutes session will be applied for a total of 8 weeks.
Study NCT05526612 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Group 2 Motor imagery, Bobath Therapeutic Approach and Physical practice (BTA+MI+PP)
Description: Individualized therapy sessions in the Bobath Therapeutic Approach with motor imagery will be performed by the physiotherapist, and in addition to these, 5 repetitions of the eating activity used in motor imagery will be practiced. 2 days a week, 30 minutes session will be applied for a total of 8 weeks.
Study NCT05383989 — intervention group
Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: UniVenture Sensation Seeking manual
Description: Intended for those who score at least 0.5 standard deviation (SD) above the population-specific norm on Sensation Seeking (SS) personality traits on the Substance Use Risk Profile Scale (SURPS)
Study NCT05383989 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: UniVenture Impulsivity manual
Description: Intended for those who score at least 0.5 standard deviation (SD) above the population-specific norm on Impulsivity (IMP) personality traits on the Substance Use Risk Profile Scale (SURPS).
Study NCT05383989 — intervention group
Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: UniVenture Impulsivity manual
Description: Intended for those who score at least 0.5 standard deviation (SD) above the population-specific norm on Impulsivity (IMP) personality traits on the Substance Use Risk Profile Scale (SURPS).
Study NCT05383989 — intervention group
Intervention type: BEHAVIORAL
Group type: PLACEBO_COMPARATOR
Intervention: Service as usual provided by the University
Description: It is the regular university-provided well-being services.
Study NCT05592782 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Virtual Reality Based Mindfulness meditation
Description: Participants will undergo a guided VR meditation using a commercial VR application. The meditation will last approximately 15 minutes. Prior to starting and on upon completion of each VR meditation session, participants' state pain, anxiety, depression, and stress will be assessed. For each participant enrolled, baseline and monthly assessments using the DASS-21 and PPI-SFI3a will be performed for three consecutive months.
Study NCT05332509 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: C-BRACE
Description: The C-BRACE is a custom made Knee-Ankle-Foot-Orthosis with a microprocessor-controlled hydraulic knee-joint articulation. The C-BRACE technology offers to a patient with knee locking deficiencies the following advantages: approximation of the physiological gait pattern, stability while standing and walking, adaptation to various surfaces, inclines, gait situations and walking speeds.
Study NCT05332509 — intervention group
Intervention type: DEVICE
Group type: OTHER
Intervention: C-BRACE
Description: The C-BRACE is a custom made Knee-Ankle-Foot-Orthosis with a microprocessor-controlled hydraulic knee-joint articulation. The C-BRACE technology offers to a patient with knee locking deficiencies the following advantages: approximation of the physiological gait pattern, stability while standing and walking, adaptation to various surfaces, inclines, gait situations and walking speeds.
Study NCT05332509 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: SCO
Description: The SCO is a custom made Knee-Ankle-Foot-Orthosis with a knee-joint locked during stance phase and released during swing phase.
Study NCT05332509 — intervention group
Intervention type: DEVICE
Group type: OTHER
Intervention: SCO
Description: The SCO is a custom made Knee-Ankle-Foot-Orthosis with a knee-joint locked during stance phase and released during swing phase.
Study NCT05861856 — intervention group
Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Manual therapy
Description: Mobilization for the spine, mobilization and relaxation methods for the soft tissues around the spine will be performed.
Study NCT05096832 — intervention group
Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Recombinant SARS-CoV-2 Fusion Protein Vaccine (V-01)
Description: Appearance: Creamy white suspension Dosage form: Suspension for injection Strength: 10 μg (0.5 mL) /vial Vaccination route: Intramuscular injection into the lateral deltoid of the upper arm Vaccination dosage: 10 μg (0.5 mL) Immunization schedule: 1 dose on Day 0, which should be 3-6 months after the second dose of 2-dose regimen of inactive vaccine (BBIBP-CorV or CoronaVac).~Storage condition: Store at 2-8 °C protected from light Expiry date: 24 months temporarily
Study NCT05096832 — intervention group
Intervention type: BIOLOGICAL
Group type: PLACEBO_COMPARATOR
Intervention: Blank Preparation of Recombinant SARS-CoV-2 Fusion Protein Vaccine (V-01)
Description: The dosage, appearance, administration method, and other aspects are consistent with that of investigational vaccine, except that no vaccine antigen is contained.
Study NCT05861856 — intervention group
Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Virtual reality
Description: Virtual reality supported core stabilization exercises will be performed.
Study NCT05125978 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Canadá
Description: Canadá association 1 tablet twice a day
Study NCT05125978 — intervention group
Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Canadá placebo
Description: Placebo of Canadá association 1 tablet twice a day
Study NCT05125978 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Dipyrone
Description: Dipyrone 1 tablet twice a day
Study NCT05125978 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Dipyrone placebo
Description: Placebo of dipyrone 1 tablet twice a day
Study NCT05125978 — intervention group
Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Dipyrone placebo
Description: Placebo of dipyrone 1 tablet twice a day
Study NCT05125978 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Tramadol hydrochloride
Description: Tramadol 1 coated tablet twice a day
Study NCT05125978 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Tramadol hydrochloride placebo
Description: Placebo of tramadol 1 coated tablet twice a day
Study NCT05125978 — intervention group
Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Tramadol hydrochloride placebo
Description: Placebo of tramadol 1 coated tablet twice a day
Study NCT05132140 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: adaptive optics system
Description: the system consists of a wavefront sensor and a deformable mirror that measure and correct (or modify) the eye's optical imperfections (aberrations).
Study NCT05468931 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Prostate stimulator
Description: Prostate stimulation device for sexual dysfunction
Study NCT05696613 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: SNP-ACTH (1-39) Gel
Description: Subjects will be randomly assigned in 1:1 treatment allocation ratio to receive the test and reference product.
Study NCT05696613 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Rituximab
Description: Subjects will be randomly assigned in 1:1 treatment allocation ratio to receive the test and reference product.
Study NCT04399486 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Physical Therapy
Description: Physical Therapy is a therapeutic exercise, education and functional activities provided on a one to one basis with a licensed Physical Therapist to meet functional goals.
Study NCT04399486 — intervention group
Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Physical Therapy
Description: Physical Therapy is a therapeutic exercise, education and functional activities provided on a one to one basis with a licensed Physical Therapist to meet functional goals.
Study NCT06527131 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: pulsed electromagnetic field therapy
Description: PEMF is regarded as an efficient physical therapy method that has been utilized clinically to treat a variety of orthopedic conditions, including delayed union and nonunion of fractures. According to studies, PEMF has been authorized for its biological effects, which include the mineralization of bone matrix, osteogenic differentiation of mesenchymal stem cells, and osteoblast proliferation
Study NCT06527131 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Transcutanous electrical nerve stimulation
Description: Electrical stimulation consider a safe and cost-effective method for pain management. It has no side effects and few contraindication in addition to no drug interaction . According to studies ,electrical stimulation decreases pain through reducing central transmission of pain signals because of nociceptive inhibition at the presynaptic level in the dorsal horn.
Study NCT06527131 — intervention group
Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Transcutanous electrical nerve stimulation
Description: Electrical stimulation consider a safe and cost-effective method for pain management. It has no side effects and few contraindication in addition to no drug interaction . According to studies ,electrical stimulation decreases pain through reducing central transmission of pain signals because of nociceptive inhibition at the presynaptic level in the dorsal horn.
Study NCT06527131 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Vancomycin
Description: medical antibiotics
Study NCT06407544 — intervention group
Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: peripheral nerve block
Description: peripheral nerve block guided by ultra sound through Ultrasound-guided quadratus lumborum block versus FICB or fascia iliaca block
Study NCT06407544 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: PCA device as rescue medication with IV morphine 1mg if VAS more than 4
Description: PCA device as rescue medication with IV morphine 1mg if VAS more than 4 with a 10 min lock-out time
Study NCT05096429 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: PROVIDENT
Description: Each of the state's 39 municipalities will be randomised to the intervention (PROVIDENT) or comparator condition. An interactive, web-based tool will be developed to visualize the PROVIDENT model predictions. Municipalities assigned to the treatment arm will receive neighborhood risk predictions from the PROVIDENT model, and state agencies and community-based organizations will direct resources to neighborhoods identified as high risk. Municipalities assigned to the control arm will continue to receive surveillance information and overdose prevention resources, but they will not receive neighborhood risk predictions from this study.
Study NCT06146426 — intervention group
Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Early diet resumption
Description: Resuming oral diet at pace started from 2 hours after extubation from ventilator.
Study NCT05569200 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Haifu Focused Ultrasound tumor therapeutic System
Description: The device used in this trial will be Haifu Focused Ultrasound tumor therapeutic System. In Uterine benign tumor female, the investigators will observe the possibility of complication and tumor response of treatment.
Study NCT05518370 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Hippotherapy simulator training
Description: Hippotherapy simulator training will be designed for the individual basis.
Study NCT05518370 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Traditional physiotherapy
Description: Traditional physiotherapy within a specific program
Study NCT05518370 — intervention group
Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Traditional physiotherapy
Description: Traditional physiotherapy within a specific program
Study NCT05845944 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Video-supported education group
Description: Providing training on nutrition with a nasogastric tube in pediatric patients with a video-supported education method
Study NCT04851821 — intervention group
Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Quercetin
Description: Each patient included, after signing the consent, will have a treatment for ten days: one tablet times three per day 30 minutes before the meal.
Study NCT04851821 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Quercetin
Description: Each patient included, after signing the consent, will have a treatment for ten days: one tablet times three per day 30 minutes before the meal.
Study NCT05938920 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: INS018_055
Description: Pharmaceutical formulation: Capsules~Mode of Administration: Oral
Study NCT05938920 — intervention group
Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Pharmaceutical formulation: Capsules~Mode of Administration: Oral
Study NCT06509503 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Combined oral contraceptive
Description: The arm will include 200 migraine patients diagnosed according to ICHD3-beta criteria. The patients are regular users of COCs and will receive propranolol 80-160mg daily and ibuprofen 200-400 mg only in acute migraine attacks for 3 months.
Study NCT06509503 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Vaginal Ring
Description: The arm will include 200 migraine patients diagnosed according to ICHD3-beta criteria. The patients are users of mechanical contraceptive methods and will receive propranolol 80-160mg daily and ibuprofen 200-400 mg only in acute migraine attacks for 3 months.
Study NCT05077709 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: IO102-IO103 in combination with pembrolizumab
Description: The experimental drug IO102-IO103 is for SC injection and consist of IDO and PD-L1 peptides
Study NCT03970954 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: low-dose IL-2
Description: Subcutaneous injection of low dose of IL-2 for induction course of 5 days, the 10th day after the beginning of periods. At most 5 courses of low dose of IL-2.
Study NCT04576832 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Mindfulness-Based Attention Training (MBAT) web-course
Description: Pre-recorded weekly sessions for 4 weeks. Each session will consist of approximately 2 hours of video content per week and weekly mindfulness exercises. This video will include MBAT program lectures, pre-recorded testimony from military leaders, and teaching materials. The course will also include 15-min daily mindfulness practice drills.
Study NCT05232266 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Caralluma Fimbriata
Description: Caralluma fimbriata in capsule form - taken as a 500mg dose (two 250mg capsules) twice daily, morning and evening with food.
Study NCT05232266 — intervention group
Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo comparator - Microcrystalline cellulose
Description: Placebo comparator in capsule form - taken as a 500mg dose (two 250mg capsules) twice daily, morning and evening with food.
Study NCT04576832 — intervention group
Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Mindfulness-Based Attention Training (MBAT) web-course
Description: Pre-recorded weekly sessions for 4 weeks. Each session will consist of approximately 2 hours of video content per week and weekly mindfulness exercises. This video will include MBAT program lectures, pre-recorded testimony from military leaders, and teaching materials. The course will also include 15-min daily mindfulness practice drills.
Study NCT06510751 — intervention group
Intervention type: OTHER
Intervention: CGRP level
Description: CGRP and substance P levels will be analysed by ELISA method in CSF and blood materials.