AIM-Harvard/TrialPanorama-filtered huggingface dataset:
Study NCT02840175 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Tocilizumab
Description: will be tapered from every 4 weeks to every 6 weeks for 24 weeks
Study NCT02127827 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Automated Ambulatory Glycemic Controller (AAGC)
Study NCT03644355 — intervention group
Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Lifestyle counseling
Description: Inter-disciplinary, interactive, family based behavioral intervention for overweight children
Study NCT03644355 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Lifestyle counseling
Description: Inter-disciplinary, interactive, family based behavioral intervention for overweight children
Study NCT02309177 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: nab-Paclitaxel
Study NCT03460496 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: neonatologists
Description: will continue to be contact persons for the APN, even after hospital discharge, and will be available for 3 fixed outpatient consultations with the APN and families that have difficulty getting to a paediatrician, because they live in a rural area with no paediatrician.
Study NCT03460496 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: psychological support
Description: Psychological support will be standard for all families. In a first consultation, psychologist and family will decide about long-term psychological support. They will have at least 3 follow-up consultations during hospital stay and one before discharge; specific psychological interventions will be provided. The aim of the interventions is to re-establish emotional stability and improve the ability of parents to cope with the situation, to prevent parental and family adaptive disorders and child developmental disorders. Support focus on screening for psychological disorders. Techniques include family-centred, holistic interventions (e.g. activating parental resources and coping, crisis intervention, stabilization techniques etc.). Parents will receive outpatient psychological support.
Study NCT03460496 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: lactation consultant
Description: during hospitalization, the lactation consultant will be involved more frequently than during standard care. Breastfeeding support will take a structured approach and will be performed in close collaboration with both parents. The main aims of structured breastfeeding support are strengthen parent-child bonding. Infants will be breastfed according to their needs. Parents will become competent in meeting their child's nutritional needs. After discharge, parents may schedule outpatient breastfeeding consultations.
Study NCT03460496 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: physiotherapeutic interventions
Description: physiotherapeutic interventions will also be structured. The physiotherapist will make an assessment during hospitalization, and decide which physiotherapeutic interventions are necessary. Each family will learn how to handle their premature child in everyday life, based on the child's developmental stage, in a single consultation.
Study NCT03460496 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: social workers
Description: social workers will closely collaborate with the APN within the transitional model. They will be involved with every family and will assist the APN in establishing a network with social and medical services within and outside the clinic. They will also support families in coping with daily life and with their integration into society, family and work. Furthermore, they will give advice on social security issues and on asserting claims as well as clarify financial possibilities.
Study NCT02338297 — intervention group
Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: TACE
Description: Transarterial chemoembolisation (TACE)
Study NCT02338297 — intervention group
Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: TACE
Description: Transarterial chemoembolisation (TACE)
Study NCT03460496 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: music therapy
Description: music therapy with premature infants and their parents creates a new dimension of contact, and helps stabilize the child and supports their development through music. It also reduces the anxiety of parents, and enhances self-efficacy and makes them more sensitive to their child 74,75, thus enhancing the parent-child relationship. In standard care, music therapy is offered only during hospitalization. In the new model of care, after NICU discharge, the program will offer 10 follow-up sessions at the family's home or in the music therapists' private practice.
Study NCT03460496 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: other health care professionals
Description: the APN will contact and involve other health care professionals, like the family's paediatrician, the outpatient midwife, the community health care nurse or the mother and father counselling as soon as need becomes evident. The APN will help set up meetings between health care professionals and the family, and will keep them up-to-date on the family's situation.
Study NCT02338297 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: EGM
Description: Occlude arterioportal shunts(APS) with ethanol/gelfoam mixture(EGM)
Study NCT02338297 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: PVA
Description: Occlude arterioportal shunts(APS) with PVA
Study NCT01729000 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Gloves
Description: All staff must wear gloves for subjects that are in the experimental group.
Study NCT03460496 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: interprofessional roundtable meetings
Description: interprofessional roundtable meetings with health care professionals involved in the care of a specific family will be held every two weeks. The meeting is aimed at developing consensus on the best possible support in the care of preterm infants and their families. Parents will be invited to participate in these meetings, led by the APN. The meeting will focus on two family situations, and then determine and initiate supportive interventions in collaboration with the parents.
Study NCT02971475 — intervention group
Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: extracorporeal shock wave lithotripsy
Description: People in this group would be treated with ESWL only.
Study NCT02971475 — intervention group
Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: endoscopic drainage of the main pancreatic duct
Description: People in this group would be treated with ESWL followed be endoscopic drainage in 48 hours.
Study NCT02971475 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Analgesics
Description: Analgesics administrated include morphine, buprenorphine, pethidine, tramaldol, metamizole and acetylsalicylacid. They will only be administrated as needed.
Study NCT02971475 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Analgesics
Description: Analgesics administrated include morphine, buprenorphine, pethidine, tramaldol, metamizole and acetylsalicylacid. They will only be administrated as needed.
Study NCT04258254 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Multimodal
Description: Multimodal intervention will involve hello songs, warm up mainly involve sensory and stretching games, music time involves playing instruments, moving game involves use of music or songs to move the whole body, yoga involves themes/songs to perform yoga poses, and good bye involves a goodbye song and reflections about the session. In all movement conditions, trainers emphasize complex and multilimb coordination (asymmetrical and ipsi/contralateral movements) and balance.
Study NCT04258254 — intervention group
Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: General
Description: The general exercise group will begin with hello games/set up and end with reflections and cleanup. Children will engage in limb and body warmup routines, specific strengthening exercises (single-joint/single-limb/symmetrical), moderate intensity endurance exercises involving various obstacle courses, and a cool down routine.
Study NCT04258254 — intervention group
Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Standard of Care
Description: The seated play group will also begin with hello/icebreaker games and end with goodbye and cleanup. In between, they will read books and review the story line and overall message and engage in fine-motor activities involving building supplies and art-craft.
Study NCT02465879 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Therapist Triage
Description: An extended role occupational or physical therapist will triage each subject in the study to determine the urgency of their case and how soon they need to see the rheumatologist.
Study NCT03460496 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Advanced practice nurses' interventions
Description: The APN will participate in comprehensively planning individual discharge, coordinating services, consulting with other healthcare professionals, assessing needs on a case by case basis, and coaching the family from birth to 6 months after discharge from the NICU. The APN will provide the Newborn Behavioral Observation (NBO), an infant-centred and family-focused method for building relationships, to parents and children, during and after hospitalization. The NBO helps sensitize parents to their infant's competencies and capabilities, teaching them to read their infant's signals and understand their behaviours. It promotes positive interactions between parent and preterm infant. The APN will also offer telephone support and follow-up Visits at home after discharge.
Study NCT01074437 — intervention group
Intervention type: DRUG
Group type: OTHER
Intervention: Prednisolone (Corticosteroid)
Description: Oral liquid prednisolone. Dose: 1-2mg/kg/day for 7 days, and then dose will be slowly reduced and then stopped after 3 weeks.
Study NCT01074437 — intervention group
Intervention type: DRUG
Group type: OTHER
Intervention: Propranolol
Description: Oral liquid propranolol will be dosed Oral liquid propranolol will be dosed at 2 mg/kg/day.
Study NCT01074437 — intervention group
Intervention type: DRUG
Group type: OTHER
Intervention: Placebo
Description: Liquid placebo will be given during the two month treatment trial.
Study NCT01956071 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: WAPD
Description: The objective was to assess workers' acceptability of the Pennington Pedal Desk.
Study NCT02835937 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: No-Transfuse
Description: Patients will not receive an otherwise-indicated red blood cell transfusion
Study NCT03060343 — intervention group
Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Zeushield Cytotoxic T Lymphocytes
Description: Three dose levels will be evaluated. Dose Level One: 1.0×10\^5 cells/kg, Dose Level Two: 1.0×10\^6 cells/kg, Dose Level Three: 1.0×10\^7 cells/kg.~At the discretion of the investigator, if patients with active disease have stable disease or a response at week 8 or on subsequent evaluations, they are eligible to receive up to 6 additional infusions at 8 to 12 week intervals.
Study NCT01275755 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo
Study NCT01275755 — intervention group
Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Study NCT01275755 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ADL5945 0.25 mg
Study NCT01013844 — intervention group
Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Skin Self Examination Information and ABCDE Rule
Description: Card with condensed information about skin self examination (SSE) and color illustrations of the ABCDE (asymmetry of shape, border irregularity, color variation, diameter > or equal to 6 mm, and evolution of the lesion) rule. A research assistant gave a skill demonstration using a magnifying lens.
Study NCT02316899 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: linaclotide
Description: Oral administration once daily
Study NCT02316899 — intervention group
Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Oral administration once daily
Study NCT04558567 — intervention group
Intervention type: DRUG
Group type: OTHER
Intervention: Vogelxo
Description: 50mg (1 tube, 5g gel) to 100mg (2 tubes, 10g gel)
Study NCT03692325 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Nivolumab
Description: Nivolumab is a type of immunotherapy. Immunotherapy works by encouraging the body's own immune system to attack cancer cells.
Study NCT04466397 — intervention group
Intervention type: DEVICE
Intervention: 3D printed individualized porous implants
Description: Use 3D printed individualized porous implants to reconstruct the large bone defects caused by tumor, infection or trauma.
Study NCT03750305 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: imagery-focused Cognitive Therapy
Description: In depth identification phase: Therapists and patient collaboratively map out difficulties and pinpoint a treatment focus.~Imagery interventions: The imagery intervention consists of metacognitive imagery rescripting or promoting positive imagery or competing tasks (or a combination of these).~Consolidation: Consist of fine tuning the strategies, relapse prevention using a video diary.
Study NCT03750305 — intervention group
Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: TAU
Description: Psycho-education is offered in groups, using the format described by Honig (Postma, Honig, \& van Gent, 2008).
Study NCT02469077 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: 6 week aerobic exercise intervention
Description: Participants randomly assigned to the 6 week aerobic exercise intervention will complete an 18 session aerobic exercise manipulation supervised by an American College of Sports Medicine-certified personal trainer (3 exercise sessions per week for 6 weeks).~Each exercise session will consist of a 5 minute warm-up, 30 minutes of aerobic exercise, followed by a 5 minute cool-down period. Aerobic exercise will consist of treadmill walking/running, stepping, elliptical, or cycling exercise as preferred by the participant. Duration of exercise will be standardized at 30 minutes with a target exercise intensity between 70-85% Heart Rate Reserve (RPE = 15, hard). Because of the focus on de-conditioned individuals with Chronic Low Back Pain, the duration and intensity of exercise will be progressively increased up to target during the first two weeks to avoid symptom exacerbation and minimize study drop-out.
Study NCT02469077 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo
Description: In randomized order (crossover) across 3 laboratory sessions each approximately 5 days apart, participants will undergo laboratory evoked thermal pain response testing with: 1) 4 doses of saline placebo (20ml each), 2) an 8mg dose of naloxone (in 20ml saline vehicle), followed by saline, 4mg naloxone, and saline, or 3) morphine sulfate (0.03 mg/kg in 20ml saline vehicle initially, followed by 3 incremental doses of 0.02mg/kg each).
Study NCT02469077 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Placebo
Description: In randomized order (crossover) across 3 laboratory sessions each approximately 5 days apart, participants will undergo laboratory evoked thermal pain response testing with: 1) 4 doses of saline placebo (20ml each), 2) an 8mg dose of naloxone (in 20ml saline vehicle), followed by saline, 4mg naloxone, and saline, or 3) morphine sulfate (0.03 mg/kg in 20ml saline vehicle initially, followed by 3 incremental doses of 0.02mg/kg each).
Study NCT02469077 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Morphine
Description: In randomized order (crossover) across 3 laboratory sessions each approximately 5 days apart, participants will undergo laboratory evoked thermal pain response testing with: 1) 4 doses of saline placebo (20ml each), 2) an 8mg dose of naloxone (in 20ml saline vehicle), followed by saline, 4mg naloxone, and saline, or 3) morphine sulfate (0.03 mg/kg in 20ml saline vehicle initially, followed by 3 incremental doses of 0.02mg/kg each).
Study NCT04042350 — intervention group
Intervention type: OTHER
Intervention: Non-interventional
Description: Exploring clinical risk factors associated with the risk for cardiovascular events and mortality, rather than to evaluate specific drugs.
Study NCT02375555 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Lenalidomide
Study NCT02375555 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Elotuzumab
Study NCT02375555 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Bortezomib
Study NCT02375555 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Dexamethasone
Study NCT02375555 — intervention group
Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Stem Cell Mobilization
Study NCT04197674 — intervention group
Intervention type: OTHER
Intervention: Dialysis modality
Description: This is a observational cohort study, and there is no intervention for all participants. Our aim is to evaluate dialysis modality (PD and HD) on patient survival
Study NCT03415789 — intervention group
Intervention type: DIAGNOSTIC_TEST
Intervention: Doppler echocardiogram exam
Description: A complete echocardiographic study will be performed at enrollment. The echocardiographic images will be acquired as clinically recommended. The protocol will include the acquisition of 1) 2D images in parasternal axis long and short axis; 2) 2D and Doppler tissue images in the apical planes of 4, 2 and 3 chambers; 3) Pulsed, continuous and color Doppler M (DCMM) of transmitral LV flow and LV ejection; 4) 3-Chamber apical plane with and without color Doppler; and 5) 3D LV images. DCMM images will be obtained from the apical window using 4 and 5 chamber planes. Blood flow velocity will be obtained using Color and Gray mode in the 3 chamber view during 5-10 beats in apnea.
Study NCT03415789 — intervention group
Intervention type: DIAGNOSTIC_TEST
Intervention: Cardiac Magnetic Resonance
Description: A cardiac MR will be acquired within 10 days after the enrollment. The protocol includes the following sequences: cine mode of short axis from LV base to apex and 2-3-4 chambers. 3D sequence of late enhancement of inversion-recovery. Images will be acquired after 3 min and 10 min of the administration of a total of 0.2 mmol / kg of Prohance®. Intraventricular thrombosis will be monitored. Phase contrast sequences in three orthogonal planes will be acquired. Morphological parameters of LV function (LVEF), contractility (Wall Motion Score ) and sphericity index will be measured.
Study NCT03415789 — intervention group
Intervention type: DIAGNOSTIC_TEST
Intervention: Brain Magnetic Resonance
Description: A brain MR will be acquired within 10 days after the enrollment. Axial, sagittal and coronal spin echo sequence in T1, axial images in diffusion sequences (DWI), enhanced spin echo T2 and FLAIR (fluid-attenuated inversion recovery) sequences shall be obtained. A cerebral infarction will be positive when finding the presence of a focal lesion of> 3 mm in diameter that meets one of these three characteristics: (1) high signal on isotropic DWI images and low signal on the apparent coefficient map Broadcast (ADC). (2) Cavitary lesion hyperintense on T2, with no signal (or low) in the FLAIR sequence. (3) Hyperintense lesion T2 / T1 hypointense with prior distribution defect known or new in a follow-up study.
Study NCT03415789 — intervention group
Intervention type: DIAGNOSTIC_TEST
Intervention: Coagulation blood test
Description: 5 ml of peripheral blood will be obtained for assessment of prothrombotic markers at enrollment.
Study NCT04446195 — intervention group
Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Individualized Intervention
Description: In this study, patients with the risk factors of insufficient intestinal preparation were treated with individualized intervention (mainly from the following aspects: chronic constipation, intestinal preparation not strictly in accordance with the requirements, body mass index > 25 kg / m2, age > 70 years old, with other diseases such as diabetes, Parkinson's disease, history of stroke or spinal cord injury, etc., application of tricyclic antidepressants or anesthetics).
Study NCT03683186 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Ralinepag
Description: Active
Study NCT02677038 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Olaparib
Description: Given PO
Study NCT04314531 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: TILD
Description: one 1 mL injection of study medication
Study NCT04314531 — intervention group
Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: matching placebo injections
Description: one 1 mL injection of placebo
Study NCT03896529 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Anticipatory psychological stress
Description: Unpredictable delivery of low-level electrical stimulation to left ankle periodically throughout psychology tasks (virtual navigation). Established procedure for inducing anticipatory stress.
Study NCT04484636 — intervention group
Intervention type: DIAGNOSTIC_TEST
Group type: OTHER
Intervention: FoundationOne®CDx and FoundationOne®Liquid
Description: FoundationOne CDx is a FDA-approved broad companion diagnostic (CDx) that is clinically and analytically validated for solid tumors. The test is designed to provide physicians with clinically actionable information - both to consider appropriate therapies for patients and understand results with evidence of resistance - based on the individual genomic profile of each patient's cancer. Every test result includes microsatellite instability (MSI) and tumor mutational burden (TMB) to help inform immunotherapy decisions. FoundationOne®Liquid is a liquid biopsy test for solid tumors that analyzes circulating tumor DNA (ctDNA) in blood.
Study NCT05830981 — intervention group
Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Educational intervention
Description: 3 months of educational intervention (Lectures, information bulletin, handbook and hardcopy presentation slides) among professionals and patients.
Study NCT02810470 — intervention group
Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Fortimel Compact Protein
Description: Each product will be tested by all patients spread over 2 days. A first half of volunteers will start the testing process with the beverages at day 1 and continue with the creams at day 2. The second half of volunteers will process inversely (day 1 = creams, day 2 = beverages). The test order of flavors will be randomly allocated to the volunteers among the list of all possible combinations.