AIM-Harvard/TrialPanorama-filtered huggingface dataset:
Study NCT04445311 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Ivermectin
Description: 3 successive days ttt of ivermectin started within 48 hours of symptoms
Study NCT04460638 — intervention group
Intervention type: BIOLOGICAL
Intervention: Saliva collection
Description: Saliva samples are regularly collected over a period of up to 30 consecutive days.
Study NCT04460638 — intervention group
Intervention type: OTHER
Intervention: Clinical assessment
Description: The participant's clinical data will be collected regularly over a period of up to 30 consecutive days.
Study NCT02062372 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: 7 T MRI
Description: Overview Technical DetailsField strength: 7 Tesla Bore size: 60 cm System length: 317,5 cm RF power: 7,5 kW / 8x1 kW Gradient strength: SC 72 Gradients (max. 70 mT/m @ 200 T/m/s) Helium Consumption: Zero Helium boil-off technology
Study NCT04177797 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Toripalimab
Description: Two cycles of Toripalimab(240 mg administered as an intravenous infusion over 30 minutes per 3 weeks), concurrently paclitaxel(135 mg/m2) and carboplatin(AUC 5) administered as an intravenous infusion per 3 weeks.
Study NCT01866696 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: oral implants
Description: For all cases, the following surgical and prosthetic protocol was followed.:~* Clinical examination~* Radiological examination~* Guided oral implants insertion~* Immediate Prosthetic loading~* Follow-up
Study NCT02062372 — intervention group
Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Biopsy
Description: During surgery patients will receive standard biopsies plus one study biopsy from a region of interest. The neuro-surgeon will determine the feasibility of the extra biopsy and the optimal biopsy tract. A screen capture from the neuronavigation system will be saved for each biopsy to relate the findings on 3T and 7T MRI to histopathology.
Study NCT01620593 — intervention group
Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: All eligible subjects will be randomized in a 1:l manner to receive a bottle containing sufficient 500mg tablets of placebo after castration, blinded to the patient and the study team.
Study NCT01620593 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Metformin
Description: All eligible subjects will be randomized in a 1:l manner to receive a bottle containing sufficient 500mg tablets of metformin after castration, blinded to the patient and the study team.
Study NCT00397553 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Insulin glulisine
Study NCT04960462 — intervention group
Intervention type: PROCEDURE
Intervention: nerve root sleeve reinforcement
Description: treatment of sacral cysts in patients with sacral cysts by using nerve root sleeve reinforcement
Study NCT04964804 — intervention group
Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: real-time ultrasound-CT fusion imaging
Description: selective lumbar nerve root block puncture under real-time ultrasound-CT fusion imaging
Study NCT04964804 — intervention group
Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: ultrasound alone
Description: selective lumbar nerve root block puncture under the guidance of ultrasound alone
Study NCT01192100 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Breakfast Skipping
Description: Participants will continue to skip breakfast each morning.
Study NCT01192100 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Normal Protein Breakfast Meals
Description: Participants will consume normal protein breakfast meals each morning.
Study NCT01192100 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Protein-rich Breakfast Meals
Description: Participants will consume protein-rich breakfast meals each morning.
Study NCT00466024 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Health Coach and HEPA Air cleaners
Description: Health Coach for ETS reduction in home and 2 HEPA air cleaners
Study NCT00466024 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Health Coach and HEPA air cleaners
Description: Behavioral training and 2 HEPA air cleaners
Study NCT00466024 — intervention group
Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Health Coach and HEPA air cleaners
Description: Behavioral training and 2 HEPA air cleaners
Study NCT04614467 — intervention group
Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: CLBS16
Description: GCSF-mobilized autologous CD34+ cells
Study NCT04614467 — intervention group
Intervention type: BIOLOGICAL
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: isotonic solution (no CD34+ cells)
Study NCT04739241 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: premixed insulin therapy
Description: Premixed insulin treatment: 30% of the calculated dose was administered before breakfast and before lunch (biphasic insulin lispro 50% or biphasic insulin aspart 50%) and the remaining 40% of the dose before dinner (biphasic insulin lispro 25% or biphasic insulin aspart insulin 30%).
Study NCT04739241 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: basal bolus insulin therapy
Description: Basal-bolus insulin treatment: 50% dose in insulin glargine and 50% dose in insulin lispro or aspartic, distributed in equal parts in the 3 main meals
Study NCT03949010 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Kinesiotaping with space correction technique
Description: Kinesiotaping with space correction technique twice per week for two weeks along with home exercise program
Study NCT03949010 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Kinesiotaping with muscle inhibition technique
Description: Kinesiotaping with muscle inhibition technique twice per week for two weeks along with home exercise program
Study NCT03949010 — intervention group
Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Home exercise program
Description: Home exercise program which consists of stretching exercises towards neck area
Study NCT03949010 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Home exercise program
Description: Home exercise program which consists of stretching exercises towards neck area
Study NCT04073641 — intervention group
Intervention type: OTHER
Intervention: No intervention
Description: No intervention
Study NCT02575989 — intervention group
Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: 1: control group
Description: Classic - current management of trauma patients by French medical teams
Study NCT02575989 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: 2: interventional group
Description: Intervention Name : monitoring, treatment, control and prevention of hypothermia~* Continuous monitoring of body temperature~* Ambulance warming (target : 30°C)~* Patient warming with dedicated blanket~* Infusion fluid warming (and temperature control)
Study NCT01158638 — intervention group
Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Web Mediated Step Intervention
Description: The testing of a web mediated step intervention designed to set weekly step targets, and channel participants through a series of motivational screens depending on compliance or non-compliance with set step goals.
Study NCT01158638 — intervention group
Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Web Mediated Step Intervention
Description: The testing of a web mediated step intervention designed to set weekly step targets, and channel participants through a series of motivational screens depending on compliance or non-compliance with set step goals.
Study NCT01520688 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Fluticasone, Budesonide, Beclomethasone
Description: Fluticasone 100 mcg bid Budesonide 180 mcg bid Beclomethasone 80 mcg bid
Study NCT01520688 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Fluticasone, Beclomethasone, Budesonide
Description: Fluticasone 100mcg BID Beclomethasone 80 mcg BID Budesonide 180 mcg BID
Study NCT01520688 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Budesonide, Fluticasone, Beclomethasone
Description: Budesonide180 mcg BID Fluticasone 100 mcg Beclomethasone 80 mcg BID
Study NCT01520688 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Budesonide, Beclomethasone, Fluticasone
Description: Budesonide 180 mcg BID Beclomethasone 80mcg BID Fluticasone 100mcg BID
Study NCT01520688 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Beclomethasone, Fluticasone, Budesonide
Description: Beclomethasone 80 mcg BID Fluticasone 100mcg BID Budesonide 180 mcg BID
Study NCT01337739 — intervention group
Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo Comparator
Description: Placebo administration (.9 normal saline sterile)
Study NCT03225664 — intervention group
Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Pembrolizumab
Description: Given IV
Study NCT03225664 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Pharmacokinetic Study
Description: Correlative studies
Study NCT03225664 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Trametinib
Description: Given PO
Study NCT04851340 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Cow's Milk
Description: Participants will consume 200 mL, 300 mL, and 400 mL of 1% bovine milk during the diet challenge which occurs on three consecutive days of the study. The first day of the diet challenge participants consume 200 mL, the second day 300 mL and the third day 400 mL.
Study NCT01520688 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Beclomethasone, Budesonide, Fluticasone
Description: Beclomethasone 80mcg BID Budesonide 180 mcg BID Fluticasone 100mcg BID
Study NCT00537771 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Anastrozole
Description: 1 mg once daily oral dose
Study NCT00537771 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Tamoxifen
Description: 20 mg once daily oral dose
Study NCT02955368 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: DP-R212
Description: DP-R212 + C1-R212 placebo + C2-R212 placebo
Study NCT04851340 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Soy Milk
Description: Participants will consume 200 mL, 300 mL, and 400 mL of soy milk during the diet challenge which occurs on three consecutive days of the study. The first day of the diet challenge participants consume 200 mL, the second day 300 mL and the third day 400 mL.
Study NCT01337739 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Active Comparator
Description: Administration of Dexmedetomidine
Study NCT03739853 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Methotrexate
Description: Used in all three arms of study
Study NCT03739853 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Methotrexate
Description: Used in all three arms of study
Study NCT03739853 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Sulfasalazine
Description: Used in arm 2 of study
Study NCT03739853 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Sulfasalazine
Description: Used in arm 2 of study
Study NCT03739853 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Leflunomide
Description: Used in arm 2 of study
Study NCT03739853 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Leflunomide
Description: Used in arm 2 of study
Study NCT03739853 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Adalimumab
Description: Used in arm 3 of the study only
Study NCT04232553 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Mirikizumab
Description: Administered IV
Study NCT04232553 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Mirikizumab
Description: Administered SC
Study NCT02955368 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: C1-R212
Description: DP-R212 placebo + C1-R212 + C2-R212 placebo
Study NCT02955368 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: C2-R212
Description: DP-R212 placebo + C1-R212 placebo + C2-R212
Study NCT02866929 — intervention group
Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Decortication
Description: Under local anesthesia, vertical and inter-radicular gingival incisions will be performed on the vestibular of the maxillary and mandibular arch, starting 2-3 mm below the interdental papilla and with sufficient depth to the periosteum to allow the scalpel to reach the alveolar bone. These incisions will be kept as small as possible; then, through them, using a piezoelectric scalpel (piezotome), several bone cuts will be performed. These cuts will have sufficient depth for drilling the cortical alveoli.
Study NCT02866929 — intervention group
Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Orthodontics
Description: Self-ligation brackets in upper and lower teeth
Study NCT02866929 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Orthodontics
Description: Self-ligation brackets in upper and lower teeth
Study NCT02866929 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Mucograft
Description: Porcine naturally cross-linked collagen matrix
Study NCT02826876 — intervention group
Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Topical use
Description: Topical use of Ropivacaine in laparoscopic surgery
Study NCT02826876 — intervention group
Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: laparoscopic repair of inguinal hernia
Description: intra-operative treatment with ropivacaine Vs placebo in laparoscopic repair of inguinal hernia
Study NCT02826876 — intervention group
Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: laparoscopic bariatric surgery
Description: intra-operative treatment with ropivacaine Vs placebo in laparoscopic bariatric surgery
Study NCT04514068 — intervention group
Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Acupuncture
Description: In each session, acupuncture are applied unilaterally or bilaterally on P6 acupoint. Each acupuncture needle will be stimulated by transcutaneous electric device.
Study NCT04514068 — intervention group
Intervention type: PROCEDURE
Group type: SHAM_COMPARATOR
Intervention: Sham acupuncture
Description: Sham acupuncture
Study NCT04645966 — intervention group
Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: MenABCWY
Description: Neisseria meningitis groups A, B, C W, and Y vaccine
Study NCT03677531 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Quality-of-Life Assessment
Description: Ancillary studies
Study NCT03677531 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Questionnaire Administration
Description: Ancillary studies
Study NCT03677531 — intervention group
Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: Radiation Therapy
Description: Undergo RT
Study NCT03677531 — intervention group
Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Video
Description: Watch video of choice during RT
Study NCT01182675 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Transplant Conditioning with Mobilization Only
Description: Day -4: Filgrastim (G-CSF) 5 mcg/kg IV q12 hours; Day -3: Filgrastim (G-CSF) 5 mcg/kg IV q12 hours; Day -2: Filgrastim (G-CSF) 5 mcg/kg IV q12 hours; Day -1: Filgrastim (G-CSF) 5 mcg/kg IV q12 hours; Day 0: Plerixafor 240 mcg/kg subcutaneous 9-12 hours prior to transplant; Day 0 Transplant
Study NCT01182675 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Transplant Conditioning with Mobilization and Alemtuzumab
Description: Day -7: Alemtuzumab 0.3 mg test dose then 0.3 mg/kg IV; Day -6: Alemtuzumab 0.3 mg/kg IV; Day -5: Alemtuzumab 0.3 mg/kg IV; Day -4: Filgrastim (G-CSF) 5 mcg/kg IV q12 hours; Day -3: Filgrastim (G-CSF) 5 mcg/kg IV q12 hours; Day -2: Filgrastim (G-CSF) 5 mcg/kg IV q12 hours; Day -1: Filgrastim (G-CSF) 5 mcg/kg IV q12 hours; Day 0: Plerixafor 240 mcg/kg subcutaneous 9-12 hours prior to transplant; Day 0: Transplant
Study NCT03326102 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: DHP107
Description: DHP107 200mg/m2 orally twice daily on Days 1, 8 and 15 every 28 days
Study NCT03326102 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: IV Paclitaxel
Description: IV Paclitaxel 80 mg/m2 QW (3 weeks on/1 week off)
Study NCT03315624 — intervention group
Intervention type: DEVICE
Group type: OTHER
Intervention: Dialyzer
Description: Three hemodiafiltration sessions assigned to one type of dialyzer FX Coral 600, FX 600 and FX CorDiax 600
Study NCT03435861 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: VX-745
Description: active drug capsules
Study NCT03435861 — intervention group
Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: placebo
Description: placebo capsules
Study NCT01663532 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Aripiprazole IM Depot
Study NCT04599062 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Talimogene Laherparepvec
Description: Talimogene Laherparepvec
Study NCT01663532 — intervention group
Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Matching Placebo
Study NCT05731778 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Stannous Fluoride Toothpaste
Description: 0.454% stannous fluoride toothpaste
Study NCT05731778 — intervention group
Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Colgate fluoride toothpaste
Description: 0.76 % Sodium MonoFluorophosphate (MFP)
Study NCT03848117 — intervention group
Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Cyriax approach i.e. DTF massage and Mill's manipulation
Description: Each patient in group I i.e. Cyriax group was given 20-minute session. Each session started in sitting position and initially deep transverse friction massage was done at lateral compartment of the elbow joint and immediately after that mill's manipulation at elbow joint with flexion at wrist joint in pronated arm position. This session was repeated three times a week for one month (Total 12 sessions/ one month).
Study NCT03848117 — intervention group
Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Mulligan approach i.e. Taping and MWM
Description: Each patient in group II i.e. Mulligan group was given 30 to 45-minute session. Each session started in sitting position and it included mobilization with movement which was given in such a way that initially lateral glide at elbow joint was performed and after holding it, I asked the patient to make a fist and open the fist. In this way, I repeated this procedure 36 times and after 12 repetitions, a short rest period was given. Taping was applied after mobilization around the elbow joint over extensor carpi radialis muscles. This session was repeated three times a week for one month (Total 12 sessions/ one month).
Study NCT01481727 — intervention group
Intervention type: DEVICE
Group type: PLACEBO_COMPARATOR
Intervention: BiPAP Pro 2, Phillips Respironics
Description: mechanical ventilation type bilevel at high intensity (>18mmHg) for at least six hours, nocturnal ventilation.
Study NCT01481727 — intervention group
Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: BiPAP Pro 2, Phillips Respironics
Description: mechanical ventilation type bilevel at high intensity (>18mmHg) for at least six hours, nocturnal ventilation.
Study NCT01481727 — intervention group
Intervention type: DEVICE
Group type: PLACEBO_COMPARATOR
Intervention: CPAP sham
Description: CPAP sham maneuver (IPAP less or equal to 4cmH2O)
Study NCT03311724 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Tirzepatide
Description: Administered SC
Study NCT03311724 — intervention group
Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Administered SC
Study NCT01633853 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Vitamin D2
Description: Treatment with Vit D2.
Study NCT01633853 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: 1,25(OH)2 Vit D3
Description: Treatment with 1,25(OH)2 Vitamin D3(Rocaltrol).
Study NCT01002027 — intervention group
Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: CBT-Counselling
Description: Intervention entailed six sessions of counselling-CBT delivered either by a trained Nurse, or by a Psychologist. Sessions focussed on: psycho-education about PND, main issues of concern, assessment of symptom severity, problem solving. Behavioural interventions (pleasant activities, anxiety management, relaxation, relationship communication) were used together with cognitive interventions (understanding links between thoughts and feelings, increasing positive thoughts, challenging negative self-talk and unhelpful beliefs).
Study NCT03539536 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Telisotuzumab vedotin
Description: Intravenous (IV) infusion
Study NCT03663816 — intervention group
Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: experimental foot device
Description: Appropriately-designed, stimulatory - but not mechanically supportive -device to enhance control of balance, postural sway and key features of walking gait in healthy people.
Study NCT04481867 — intervention group
Intervention type: PROCEDURE
Group type: OTHER
Intervention: densah bur
Description: osseodensification densah bur
Study NCT04481867 — intervention group
Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: densah bur
Description: osseodensification densah bur
Study NCT01308060 — intervention group
Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Botulinum Toxin Type A
Description: During part A, Azzalure will be administered at Baseline 60 Speywood units at canthal lines and compared with placebo.
Study NCT01308060 — intervention group
Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Study NCT04599062 — intervention group
Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Talimogene Laherparepvec
Description: Talimogene Laherparepvec