AIM-Harvard/TrialPanorama-filtered huggingface dataset:
Study 12872052 — Biomarker: High density lipoprotein cholesterol
Type: Pharmacodynamic Biomarker (PDY)
Study 12872052 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 2508341 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 189328 — Biomarker: POMC
Type: Predictive Biomarker (PRD)
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 31234927 — Biomarker: Erbb2 tyrosine kinase receptor
Type: Predictive Biomarker (PRD)
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 25969155 — Biomarker: EMP1 mRNA
Type: Predictive Biomarker (PRD)
Genes: EMP1; B4B; TMP
Study 12665918 — Biomarker: HBV DNA
Type: Monitoring Biomarker (MOI)
Study 28945850 — Biomarker: Epidermal growth factor receptor
Type: Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: EGFR; ERBB; ERBB1; HER1
Study 25784519 — Biomarker: MB mRNA
Type: Predictive Biomarker (PRD)
Genes: MB
Study 22626867 — Biomarker: HPSE mRNA
Type: Predictive Biomarker (PRD)
Genes: HPSE; HEP; HPA; HPA1; HPR1; HPSE1; HSE1
Study 17700043 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 11483846 — Biomarker: Immunoglobulin E
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Study 28686199 — Biomarker: HR mRNA
Type: Predictive Biomarker (PRD)
Genes: HR
Study 16760409 — Biomarker: Macrophage inflammatory protein 1-alpha
Type: Monitoring Biomarker (MOI)
Genes: CCL3; G0S19-1; MIP1A; SCYA3
Study 16760409 — Biomarker: C-C motif chemokine 4
Type: Monitoring Biomarker (MOI)
Genes: CCL4; LAG1; MIP1B; SCYA4
Study 14735686 — Biomarker: CSF3 mRNA
Type: Predictive Biomarker (PRD)
Genes: CSF3; C17orf33; GCSF
Study 9123739 — Biomarker: GNRH1 mRNA
Type: Predictive Biomarker (PRD)
Genes: GNRH1; GNRH; GRH; LHRH
Study 9123739 — Biomarker: NPEPPS mRNA
Type: Predictive Biomarker (PRD)
Genes: NPEPPS; PSA
Study 26086689 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 20584260 — Biomarker: Gastric inhibitory polypeptide
Type: Pharmacodynamic Biomarker (PDY)
Genes: GIP
Study 20584260 — Biomarker: PYY mRNA
Type: Predictive Biomarker (PRD)
Genes: PYY
Study 17354241 — Biomarker: Cervical intraepithelial neoplasia
Type: Surrogate Endpoint (SUR)
Study 15716285 — Biomarker: CD40 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD40; TNFRSF5
Study 15716285 — Biomarker: TNF related activation protein
Type: Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CD40LG; CD40L; TNFSF5; TRAP
Study 15716285 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 9468739 — Biomarker: CBS mRNA
Type: Predictive Biomarker (PRD)
Genes: CBS
Study 9468739 — Biomarker: LTB mRNA
Type: Predictive Biomarker (PRD)
Genes: LTB; TNFC; TNFSF3
Study 25910889 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 23306077 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 18503398 — Biomarker: CYP2C9 mRNA
Type: Predictive Biomarker (PRD)
Genes: CYP2C9; CYP2C10
Study 12905468 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 9336364 — Biomarker: Leukocyte surface antigen Leu-16
Type: Predictive Biomarker (PRD)
Genes: MS4A1; CD20
Study 29143161 — Biomarker: B-type natriuretic peptide
Type: Safety Biomarker (SAF)
Genes: NPPB
Study 7681894 — Biomarker: HR mRNA
Type: Predictive Biomarker (PRD)
Genes: HR
Study 7681894 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 3752480 — Biomarker: TPR mRNA
Type: Predictive Biomarker (PRD)
Genes: TPR
Study 3752480 — Biomarker: HR mRNA
Type: Predictive Biomarker (PRD)
Genes: HR
Study 26420590 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 26420590 — Biomarker: Blood coagulation
Type: Pharmacodynamic Biomarker (PDY)
Study 23743397 — Biomarker: Interleukin 6
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: IL6; IFNB2
Study 21649830 — Biomarker: ACP7 mRNA
Type: Predictive Biomarker (PRD)
Genes: ACP7; PAPL; PAPL1
Study 15536462 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 9232213 — Biomarker: CCK mRNA
Type: Predictive Biomarker (PRD)
Genes: CCK
Study 26331608 — Biomarker: CYP21A2 mRNA
Type: Predictive Biomarker (PRD)
Genes: CYP21A2; CYP21; CYP21B
Study 30290902 — Biomarker: Lymphocyte activation antigen CD30
Type: Predictive Biomarker (PRD)
Genes: TNFRSF8; CD30; D1S166E
Study 25209438 — Biomarker: TRPV6 mRNA
Type: Predictive Biomarker (PRD)
Genes: TRPV6; ECAC2
Study 25209438 — Biomarker: Bone mineral density
Type: Surrogate Endpoint (SUR)
Study 22220931 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 22220931 — Biomarker: Interleukin 6
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: IL6; IFNB2
Study 22220931 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 28705181 — Biomarker: CD4 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD4
Study 21182509 — Biomarker: Eosinophil cationic protein
Type: Safety Biomarker (SAF)
Genes: RNASE3; ECP; RNS3
Study 17511722 — Biomarker: NPEPPS mRNA
Type: Predictive Biomarker (PRD)
Genes: NPEPPS; PSA
Study 8275737 — Biomarker: Forced vital capacity
Type: Surrogate Endpoint (SUR)
Study 25545540 — Biomarker: HR mRNA
Type: Predictive Biomarker (PRD)
Genes: HR
Study 22562973 — Biomarker: Adenosine deaminase
Type: Monitoring Biomarker (MOI)
Genes: ADA; ADA1
Study 22562973 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 18446847 — Biomarker: Endothelin-1
Type: Safety Biomarker (SAF); Monitoring Biomarker (MOI)
Genes: EDN1
Study 16946216 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 9135961 — Biomarker: SAT1 mRNA
Type: Predictive Biomarker (PRD)
Genes: SAT1; SAT
Study 8212369 — Biomarker: Pulmonary vascular resistance
Type: Surrogate Endpoint (SUR)
Study 3096035 — Biomarker: TRH mRNA
Type: Predictive Biomarker (PRD)
Genes: TRH
Study 3096035 — Biomarker: TBXT mRNA
Type: Predictive Biomarker (PRD)
Genes: TBXT; T
Study 26586786 — Biomarker: MTTP mRNA
Type: Predictive Biomarker (PRD)
Genes: MTTP; MTP
Study 26586786 — Biomarker: MB mRNA
Type: Predictive Biomarker (PRD)
Genes: MB
Study 2139413 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 22504653 — Biomarker: CS mRNA
Type: Predictive Biomarker (PRD)
Genes: CS
Study 22504653 — Biomarker: CD69 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD69; CLEC2C
Study 16344839 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 15905753 — Biomarker: HR mRNA
Type: Predictive Biomarker (PRD)
Genes: HR
Study 8822756 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 8822756 — Biomarker: Thyroid stimulating hormone
Type: Safety Biomarker (SAF)
Study 29300423 — Biomarker: Vitamin B12
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI)
Study 26427866 — Biomarker: HR mRNA
Type: Predictive Biomarker (PRD)
Genes: HR
Study 26427866 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 1835850 — Biomarker: CP mRNA
Type: Predictive Biomarker (PRD)
Genes: CP
Study 27419081 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 23824624 — Biomarker: Granulocyte-macrophage colony-stimulating factor
Type: Safety Biomarker (SAF)
Genes: CSF2; GMCSF
Study 23824624 — Biomarker: Cervical intraepithelial neoplasia
Type: Surrogate Endpoint (SUR)
Study 20726255 — Biomarker: HDC mRNA
Type: Predictive Biomarker (PRD)
Genes: HDC
Study 25453457 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 22307842 — Biomarker: B-type natriuretic peptide
Type: Safety Biomarker (SAF)
Genes: NPPB
Study 22307842 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 15920225 — Biomarker: von Willebrand factor
Type: Safety Biomarker (SAF)
Genes: VWF; F8VWF
Study 28239939 — Biomarker: FFAR1 mRNA
Type: Predictive Biomarker (PRD)
Genes: FFAR1; GPR40
Study 28239939 — Biomarker: Dipeptidyl peptidase 4
Type: Pharmacodynamic Biomarker (PDY)
Genes: DPP4; ADCP2; CD26
Study 25806587 — Biomarker: PC mRNA
Type: Predictive Biomarker (PRD)
Genes: PC
Study 7927958 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 7927958 — Biomarker: High density lipoprotein cholesterol
Type: Pharmacodynamic Biomarker (PDY)
Study 2502890 — Biomarker: CD14 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD14
Study 2502890 — Biomarker: Interleukin 2 receptor alpha
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: IL2RA
Study 21300618 — Biomarker: Cervical intraepithelial neoplasia
Type: Surrogate Endpoint (SUR)
Study 12221048 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 6143184 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 25917895 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 20736449 — Biomarker: TNF related activation protein
Type: Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CD40LG; CD40L; TNFSF5; TRAP
Study 20736449 — Biomarker: CD40 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD40; TNFRSF5
Study 18515817 — Biomarker: AFP mRNA
Type: Predictive Biomarker (PRD)
Genes: AFP; HPAFP
Study 18515817 — Biomarker: White blood cell
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Study 12782208 — Biomarker: CCK mRNA
Type: Predictive Biomarker (PRD)
Genes: CCK
Study 12782208 — Biomarker: Gastric inhibitory polypeptide
Type: Pharmacodynamic Biomarker (PDY)
Genes: GIP
Study 12782208 — Biomarker: Plasma phenylalanine
Type: Surrogate Endpoint (SUR)
Study 9160584 — Biomarker: CCK mRNA
Type: Predictive Biomarker (PRD)
Genes: CCK
Study 9160584 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 2912330 — Biomarker: Pulmonary vascular resistance
Type: Surrogate Endpoint (SUR)
Study 25779951 — Biomarker: CD4 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD4
Study 24113059 — Biomarker: APC mRNA
Type: Predictive Biomarker (PRD)
Genes: APC; DP2.5
Study 9168369 — Biomarker: Serum albumin
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY)
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 26050790 — Biomarker: PRKRA mRNA
Type: Predictive Biomarker (PRD)
Genes: PRKRA; PACT; RAX; HSD-14; HSD14
Study 19351690 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 16957557 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 11110735 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 9066184 — Biomarker: Eosinophil cationic protein
Type: Safety Biomarker (SAF)
Genes: RNASE3; ECP; RNS3
Study 8332009 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 8332009 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 29722619 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 20046173 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 21613384 — Biomarker: MTHFR
Type: Safety Biomarker (SAF)
Study 18327092 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 22254048 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 22254048 — Biomarker: Interleukin 1
Type: Safety Biomarker (SAF)
Study 9528165 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 9528165 — Biomarker: White blood cell
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Study 21805462 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 9042042 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 9042042 — Biomarker: Eosinophil cationic protein
Type: Safety Biomarker (SAF)
Genes: RNASE3; ECP; RNS3
Study 25609939 — Biomarker: Cytochrome P450 2D6
Type: Safety Biomarker (SAF)
Genes: CYP2D6; CYP2DL1
Study 25609939 — Biomarker: CYP3A4 mRNA
Type: Predictive Biomarker (PRD)
Genes: CYP3A4; CYP3A3
Study 16637791 — Biomarker: Serum creatinine
Type: Surrogate Endpoint (SUR)
Study 16637791 — Biomarker: Thyroid stimulating hormone
Type: Safety Biomarker (SAF)
Study 8646249 — Biomarker: Free fatty acids
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY)
Study 24743062 — Biomarker: LBP mRNA
Type: Predictive Biomarker (PRD)
Genes: LBP
Study 18158077 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 18158077 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 18158077 — Biomarker: High density lipoprotein cholesterol
Type: Pharmacodynamic Biomarker (PDY)
Study 7650808 — Biomarker: White blood cell
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Study 22930789 — Biomarker: OSR1 mRNA
Type: Predictive Biomarker (PRD)
Genes: OSR1; ODD
Study 22930789 — Biomarker: CTLA4
Type: Predictive Biomarker (PRD)
Genes: CD152; CD; GSE; CTLA-4
Study 23646472 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 23646472 — Biomarker: Chitinase-3-like protein 1
Type: Predictive Biomarker (PRD); Monitoring Biomarker (MOI)
Genes: CHI3L1
Study 23646472 — Biomarker: High density lipoprotein cholesterol
Type: Pharmacodynamic Biomarker (PDY)
Study 23646472 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 22195356 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 11598594 — Biomarker: Bone mineral density
Type: Surrogate Endpoint (SUR)
Study 7985599 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 7985599 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 7985599 — Biomarker: High density lipoprotein cholesterol
Type: Pharmacodynamic Biomarker (PDY)
Study 31196815 — Biomarker: SLC5A2 mRNA
Type: Predictive Biomarker (PRD)
Genes: SLC5A2; SGLT2
Study 28298543 — Biomarker: MXD1 mRNA
Type: Predictive Biomarker (PRD)
Genes: MXD1; MAD
Study 11249629 — Biomarker: Antithrombin-III
Type: Safety Biomarker (SAF)
Genes: SERPINC1; AT3; PRO0309
Study 31420735 — Biomarker: AR mRNA
Type: Predictive Biomarker (PRD)
Genes: AR; DHTR; NR3C4
Study 20546013 — Biomarker: TG mRNA
Type: Predictive Biomarker (PRD)
Genes: TG
Study 20546013 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 18794647 — Biomarker: Cytochrome P450 2D6
Type: Safety Biomarker (SAF)
Genes: CYP2D6; CYP2DL1
Study 18794647 — Biomarker: CYP1A2 mRNA
Type: Predictive Biomarker (PRD)
Genes: CYP1A2
Study 31141968 — Biomarker: PYY mRNA
Type: Predictive Biomarker (PRD)
Genes: PYY
Study 15451912 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 31647902 — Biomarker: REM1 mRNA
Type: Predictive Biomarker (PRD)
Genes: REM1; GES; REM
Study 29196161 — Biomarker: MCAT mRNA
Type: Predictive Biomarker (PRD)
Genes: MCAT; MT
Study 28370401 — Biomarker: Granulocyte-macrophage colony-stimulating factor
Type: Safety Biomarker (SAF)
Genes: CSF2; GMCSF
Study 28370401 — Biomarker: CD34 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD34
Study 26510013 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 20378601 — Biomarker: Pulmonary vascular resistance
Type: Surrogate Endpoint (SUR)
Study 18803046 — Biomarker: TERF1 mRNA
Type: Predictive Biomarker (PRD)
Genes: TERF1; PIN2; TRBF1; TRF; TRF1
Study 16533589 — Biomarker: BRCA1 mRNA
Type: Predictive Biomarker (PRD)
Genes: BRCA1; RNF53
Study 16533589 — Biomarker: BRCA2 mRNA
Type: Predictive Biomarker (PRD)
Genes: BRCA2; FACD; FANCD1
Study 23111749 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 12794024 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 12794024 — Biomarker: Interleukin 6
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: IL6; IFNB2
Study 10695096 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 8934359 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 31835039 — Biomarker: Activated leukocyte cell adhesionmolecule
Type: Predictive Biomarker (PRD)
Genes: ALCAM; MEMD
Study 31835039 — Biomarker: B-type natriuretic peptide
Type: Safety Biomarker (SAF)
Genes: NPPB
Study 22703383 — Biomarker: IGFALS mRNA
Type: Predictive Biomarker (PRD)
Genes: IGFALS; ALS
Study 9458998 — Biomarker: Arginine vasopressin
Type: Predictive Biomarker (PRD)
Genes: AVP; ARVP; VP
Study 20649879 — Biomarker: Bone mineral density
Type: Surrogate Endpoint (SUR)
Study 10933355 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 10933355 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 21717778 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 17217712 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 17217712 — Biomarker: PIP mRNA
Type: Predictive Biomarker (PRD)
Genes: PIP; GCDFP15; GPIP4
Study 17217712 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 17217712 — Biomarker: Superoxide dismutase Cu-Zn
Type: Pharmacodynamic Biomarker (PDY)
Genes: SOD1
Study 27262236 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 10094976 — Biomarker: Interleukin 12
Type: Safety Biomarker (SAF)
Study 10094976 — Biomarker: Interferon gamma
Type: Safety Biomarker (SAF); Monitoring Biomarker (MOI)
Genes: IFNG
Study 31171016 — Biomarker: MFSD11 mRNA
Type: Predictive Biomarker (PRD)
Genes: MFSD11; ET
Study 20934829 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 19193505 — Biomarker: Complement C3
Type: Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: C3; CPAMD1
Study 19193505 — Biomarker: High density lipoprotein cholesterol
Type: Pharmacodynamic Biomarker (PDY)
Study 19193505 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 3548602 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 25047497 — Biomarker: CYP3A4 mRNA
Type: Predictive Biomarker (PRD)
Genes: CYP3A4; CYP3A3
Study 11303372 — Biomarker: Interleukin 2
Type: Safety Biomarker (SAF)
Genes: IL2
Study 1446996 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 2870353 — Biomarker: GNRH1 mRNA
Type: Predictive Biomarker (PRD)
Genes: GNRH1; GNRH; GRH; LHRH
Study 2870353 — Biomarker: Serum testosterone
Type: Surrogate Endpoint (SUR)
Study 30529119 — Biomarker: SPTB mRNA
Type: Predictive Biomarker (PRD)
Genes: SPTB; SPTB1
Study 19294693 — Biomarker: P4HB mRNA
Type: Predictive Biomarker (PRD)
Genes: P4HB; ERBA2L; PDI; PDIA1; PO4DB
Study 19294693 — Biomarker: Phospholipase A2 inhibitory protein
Type: Predictive Biomarker (PRD)
Genes: ANXA1; ANX1; LPC1
Study 15470336 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 30905430 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 21415071 — Biomarker: B-type natriuretic peptide
Type: Safety Biomarker (SAF)
Genes: NPPB
Study 11479880 — Biomarker: Intercellular adhesion molecule 1
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: ICAM1
Study 30431384 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 15715683 — Biomarker: EDNRA mRNA
Type: Predictive Biomarker (PRD)
Genes: EDNRA; ETA; ETRA
Study 15715683 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 15715683 — Biomarker: Endothelin-1
Type: Safety Biomarker (SAF); Monitoring Biomarker (MOI)
Genes: EDN1
Study 1345033 — Biomarker: Hydroxyphenylpyruvate dioxygenase
Type: Safety Biomarker (SAF)
Genes: HPD; PPD
Study 26386921 — Biomarker: PAH mRNA
Type: Predictive Biomarker (PRD)
Genes: PAH
Study 25563795 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 25563795 — Biomarker: High density lipoprotein cholesterol
Type: Pharmacodynamic Biomarker (PDY)
Study 21138533 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 18426991 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 30373342 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 3795978 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 3795978 — Biomarker: Free fatty acids
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY)
Study 31694861 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 20713915 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 12610843 — Biomarker: Heat pain threshold
Type: Pharmacodynamic Biomarker (PDY)
Study 17075807 — Biomarker: Complement C3
Type: Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: C3; CPAMD1
Study 3277680 — Biomarker: White blood cell
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Study 12409970 — Biomarker: Serum creatinine
Type: Surrogate Endpoint (SUR)
Study 7584486 — Biomarker: CD5 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD5; LEU1
Study 31254640 — Biomarker: CNP mRNA
Type: Predictive Biomarker (PRD)
Genes: CNP
Study 31254640 — Biomarker: BPI mRNA
Type: Predictive Biomarker (PRD)
Genes: BPI
Study 26576593 — Biomarker: KIT mRNA
Type: Predictive Biomarker (PRD)
Genes: KIT; SCFR
Study 26576593 — Biomarker: PDGFRB mRNA
Type: Predictive Biomarker (PRD)
Genes: PDGFRB; PDGFR; PDGFR1
Study 26576593 — Biomarker: Vascular endothelial growth factor A
Type: Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: VEGFA; VEGF
Study 26576593 — Biomarker: Vascular endothelial growth factor
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY)
Study 19635893 — Biomarker: MB mRNA
Type: Predictive Biomarker (PRD)
Genes: MB
Study 16413239 — Biomarker: Interleukin 6
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: IL6; IFNB2
Study 16413239 — Biomarker: D-dimer
Type: Safety Biomarker (SAF); Monitoring Biomarker (MOI)
Study 9364542 — Biomarker: Granulocyte-macrophage colony-stimulating factor
Type: Safety Biomarker (SAF)
Genes: CSF2; GMCSF
Study 8496758 — Biomarker: Serum calcium
Type: Surrogate Endpoint (SUR)
Study 23844613 — Biomarker: TPO mRNA
Type: Predictive Biomarker (PRD)
Genes: TPO
Study 21186534 — Biomarker: HBV DNA
Type: Monitoring Biomarker (MOI)
Study 11982739 — Biomarker: Thyroid stimulating hormone
Type: Safety Biomarker (SAF)
Study 10432413 — Biomarker: Endothelin-1
Type: Safety Biomarker (SAF); Monitoring Biomarker (MOI)
Genes: EDN1
Study 10432413 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1