AIM-Harvard/TrialPanorama-filtered huggingface dataset:
Study 15164330 — Biomarker: Free fatty acids
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY)
Study 10676671 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 12840090 — Biomarker: Serum creatinine
Type: Surrogate Endpoint (SUR)
Study 8712092 — Biomarker: NPEPPS mRNA
Type: Predictive Biomarker (PRD)
Genes: NPEPPS; PSA
Study 11095473 — Biomarker: IGFALS mRNA
Type: Predictive Biomarker (PRD)
Genes: IGFALS; ALS
Study 25753488 — Biomarker: Dipeptidyl peptidase 4
Type: Pharmacodynamic Biomarker (PDY)
Genes: DPP4; ADCP2; CD26
Study 27406165 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 16213286 — Biomarker: Serum creatinine
Type: Surrogate Endpoint (SUR)
Study 6337285 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 25095656 — Biomarker: Intact parathyroid hormone
Type: Predictive Biomarker (PRD)
Study 25095656 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 25095656 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 12096825 — Biomarker: SHBG mRNA
Type: Predictive Biomarker (PRD)
Genes: SHBG
Study 31331552 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 27653670 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 25350366 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 24332919 — Biomarker: Neutrophil gelatinase-associated lipocalin
Type: Safety Biomarker (SAF); Monitoring Biomarker (MOI)
Genes: LCN2; HNL; NGAL
Study 24332919 — Biomarker: Serum creatinine
Type: Surrogate Endpoint (SUR)
Study 24332919 — Biomarker: Cystatin C
Type: Safety Biomarker (SAF)
Genes: CST3
Study 17007855 — Biomarker: HSPA2 mRNA
Type: Predictive Biomarker (PRD)
Genes: HSPA2
Study 15096570 — Biomarker: MTHFR
Type: Safety Biomarker (SAF)
Study 15096570 — Biomarker: Plasminogen activator inhibitor
Type: Safety Biomarker (SAF)
Genes: SERPINE1; PAI1; PLANH1
Study 21627686 — Biomarker: Angiotensinogenase renin
Type: Pharmacodynamic Biomarker (PDY)
Genes: REN
Study 21627686 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 9470829 — Biomarker: Interferon gamma
Type: Safety Biomarker (SAF); Monitoring Biomarker (MOI)
Genes: IFNG
Study 7895954 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 12783047 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 3758239 — Biomarker: FEV mRNA
Type: Predictive Biomarker (PRD)
Genes: FEV; PET1
Study 28757316 — Biomarker: HGD mRNA
Type: Predictive Biomarker (PRD)
Genes: HGD; HGO
Study 12439841 — Biomarker: Serum creatinine
Type: Surrogate Endpoint (SUR)
Study 8229755 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 30246320 — Biomarker: TTN mRNA
Type: Predictive Biomarker (PRD)
Genes: TTN
Study 10493325 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 7495583 — Biomarker: Serum potassium
Type: Surrogate Endpoint (SUR)
Study 28560519 — Biomarker: Serum triglycerides
Type: Surrogate Endpoint (SUR)
Study 24465617 — Biomarker: CD4 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD4
Study 15083365 — Biomarker: CFH mRNA
Type: Predictive Biomarker (PRD)
Genes: CFH; HF; HF1; HF2
Study 11786110 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 11786110 — Biomarker: Serum calcium
Type: Surrogate Endpoint (SUR)
Study 22480515 — Biomarker: Natriuretic peptides A
Type: Safety Biomarker (SAF)
Genes: NPPA; ANP; PND
Study 22480515 — Biomarker: Endothelin-1
Type: Safety Biomarker (SAF); Monitoring Biomarker (MOI)
Genes: EDN1
Study 22480515 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 19353750 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 10466475 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 10466475 — Biomarker: Serum uric acid
Type: Surrogate Endpoint (SUR)
Study 2192585 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 2192585 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 21624736 — Biomarker: B-type natriuretic peptide
Type: Safety Biomarker (SAF)
Genes: NPPB
Study 2297461 — Biomarker: CCK mRNA
Type: Predictive Biomarker (PRD)
Genes: CCK
Study 11899582 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 28182820 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 28182820 — Biomarker: Interleukin 6
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: IL6; IFNB2
Study 28182820 — Biomarker: Urokinase plasminogen activator surface receptor
Type: Monitoring Biomarker (MOI)
Genes: PLAUR; MO3; UPAR
Study 28182820 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 24314824 — Biomarker: CGA mRNA
Type: Predictive Biomarker (PRD)
Genes: CGA
Study 15373934 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 9011463 — Biomarker: PTPRC mRNA
Type: Predictive Biomarker (PRD)
Genes: PTPRC; CD45
Study 15165613 — Biomarker: CD4 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD4
Study 31982148 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 31982148 — Biomarker: Serum albumin
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY)
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 31982148 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 31570429 — Biomarker: ANO7 mRNA
Type: Predictive Biomarker (PRD)
Genes: ANO7; NGEP; PCANAP5; TMEM16G
Study 15031430 — Biomarker: LBP mRNA
Type: Predictive Biomarker (PRD)
Genes: LBP
Study 6998872 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 6998872 — Biomarker: Serum sodium
Type: Surrogate Endpoint (SUR)
Study 29722252 — Biomarker: Lactate dehydrogenase
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Study 28616715 — Biomarker: AMD1 mRNA
Type: Predictive Biomarker (PRD)
Genes: AMD1; AMD
Study 24080992 — Biomarker: GNRH1 mRNA
Type: Predictive Biomarker (PRD)
Genes: GNRH1; GNRH; GRH; LHRH
Study 24080992 — Biomarker: DMD
Type: Predictive Biomarker (PRD)
Genes: BMD; DXS142; DXS164; DXS206; DXS230; DXS239; DXS268; DXS269; DXS270; DXS272
Study 24080992 — Biomarker: Bone mineral density
Type: Surrogate Endpoint (SUR)
Study 17143195 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 9039836 — Biomarker: SAT1 mRNA
Type: Predictive Biomarker (PRD)
Genes: SAT1; SAT
Study 2087150 — Biomarker: STS mRNA
Type: Predictive Biomarker (PRD)
Genes: STS; ARSC1
Study 28689036 — Biomarker: Serum creatinine
Type: Surrogate Endpoint (SUR)
Study 20957391 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 20957391 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 14969650 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 31564046 — Biomarker: TERT mRNA
Type: Predictive Biomarker (PRD)
Genes: TERT; EST2; TCS1; TRT
Study 29653820 — Biomarker: Epidermal growth factor receptor
Type: Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: EGFR; ERBB; ERBB1; HER1
Study 12494207 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 7877305 — Biomarker: ITGB2 mRNA
Type: Predictive Biomarker (PRD)
Genes: ITGB2; CD18; MFI7
Study 8903664 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 10605180 — Biomarker: GNRH1 mRNA
Type: Predictive Biomarker (PRD)
Genes: GNRH1; GNRH; GRH; LHRH
Study 30193843 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 30193843 — Biomarker: Interleukin 6
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: IL6; IFNB2
Study 12051573 — Biomarker: TG mRNA
Type: Predictive Biomarker (PRD)
Genes: TG
Study 7728405 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 28627980 — Biomarker: HR mRNA
Type: Predictive Biomarker (PRD)
Genes: HR
Study 15469648 — Biomarker: Gastric inhibitory polypeptide
Type: Pharmacodynamic Biomarker (PDY)
Genes: GIP
Study 11289332 — Biomarker: Forced vital capacity
Type: Surrogate Endpoint (SUR)
Study 2647896 — Biomarker: MSC mRNA
Type: Predictive Biomarker (PRD)
Genes: MSC; ABF1; BHLHA22
Study 19043376 — Biomarker: Bone mineral density
Type: Surrogate Endpoint (SUR)
Study 7379443 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 19033683 — Biomarker: Plasminogen activator inhibitor
Type: Safety Biomarker (SAF)
Genes: SERPINE1; PAI1; PLANH1
Study 18167250 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 9703298 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 2644144 — Biomarker: CD4 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD4
Study 2644144 — Biomarker: Interleukin 2
Type: Safety Biomarker (SAF)
Genes: IL2
Study 24633493 — Biomarker: Bone mineral density
Type: Surrogate Endpoint (SUR)
Study 19423079 — Biomarker: Interleukin 6
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: IL6; IFNB2
Study 17443133 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 31087530 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 31087530 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 22431837 — Biomarker: Microtubule-associated protein tau
Type: Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY)
Genes: MAPT; MAPTL; MTBT1; TAU
Study 31562796 — Biomarker: Programmed cell death 1 ligand 1
Type: Predictive Biomarker (PRD)
Genes: CD274; B7H1; PDCD1L1; PDCD1LG1; PDL1
Study 26253612 — Biomarker: MTIF3 mRNA
Type: Predictive Biomarker (PRD)
Genes: MTIF3; DC38
Study 21530317 — Biomarker: Pulmonary vascular resistance
Type: Surrogate Endpoint (SUR)
Study 16497685 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 16497685 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 12867351 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 30009729 — Biomarker: S100B mRNA
Type: Predictive Biomarker (PRD)
Genes: S100B
Study 26701977 — Biomarker: Intact parathyroid hormone
Type: Predictive Biomarker (PRD)
Study 24386861 — Biomarker: PDZD2 mRNA
Type: Predictive Biomarker (PRD)
Genes: PDZD2; AIPC; KIAA0300; PDZK3
Study 24386861 — Biomarker: NPEPPS mRNA
Type: Predictive Biomarker (PRD)
Genes: NPEPPS; PSA
Study 24386861 — Biomarker: GNRH1 mRNA
Type: Predictive Biomarker (PRD)
Genes: GNRH1; GNRH; GRH; LHRH
Study 18821290 — Biomarker: Bone mineral density
Type: Surrogate Endpoint (SUR)
Study 18821290 — Biomarker: Serum testosterone
Type: Surrogate Endpoint (SUR)
Study 20393454 — Biomarker: CYP3A5 mRNA
Type: Predictive Biomarker (PRD)
Genes: CYP3A5
Study 10726961 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 29752028 — Biomarker: GAST mRNA
Type: Predictive Biomarker (PRD)
Genes: GAST; GAS
Study 20194698 — Biomarker: Glucose-6-phosphate dehydrogenase
Type: Safety Biomarker (SAF)
Genes: G6PD
Study 10489947 — Biomarker: CD4 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD4
Study 1827014 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 30350117 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 14985887 — Biomarker: MCAT mRNA
Type: Predictive Biomarker (PRD)
Genes: MCAT; MT
Study 11737399 — Biomarker: CD4 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD4
Study 8273984 — Biomarker: Vitamin B12
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI)
Study 27646264 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 27646264 — Biomarker: Intercellular adhesion molecule 1
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: ICAM1
Study 27646264 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 18317424 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 13680036 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 29705444 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 12842840 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 10832123 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 1639462 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 31117149 — Biomarker: NNT mRNA
Type: Predictive Biomarker (PRD)
Genes: NNT
Study 28341106 — Biomarker: Epidermal growth factor receptor
Type: Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: EGFR; ERBB; ERBB1; HER1
Study 19337944 — Biomarker: Hyaluronic acid
Type: Safety Biomarker (SAF)
Study 16849403 — Biomarker: Serum luteinizing hormone
Type: Surrogate Endpoint (SUR)
Study 8477962 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 8477962 — Biomarker: High density lipoprotein cholesterol
Type: Pharmacodynamic Biomarker (PDY)
Study 20526599 — Biomarker: PAM mRNA
Type: Predictive Biomarker (PRD)
Genes: PAM
Study 16497254 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 12559536 — Biomarker: Proto-oncogene c-Met
Type: Predictive Biomarker (PRD)
Genes: MET
Study 15806263 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 26664107 — Biomarker: Forced vital capacity
Type: Surrogate Endpoint (SUR)
Study 19926008 — Biomarker: High density lipoprotein cholesterol
Type: Pharmacodynamic Biomarker (PDY)
Study 22252800 — Biomarker: Glucose-6-phosphate dehydrogenase
Type: Safety Biomarker (SAF)
Genes: G6PD
Study 16130059 — Biomarker: Interleukin 6
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: IL6; IFNB2
Study 8757425 — Biomarker: TNFR1B
Type: Predictive Biomarker (PRD)
Genes: TNFRSF1B; TNFBR; TNFR80; TNF-R75; TNF-R-II; p75; CD120b
Study 8757425 — Biomarker: CD4 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD4
Study 8757425 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 24436491 — Biomarker: Serum albumin
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY)
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 22952598 — Biomarker: Serum triglycerides
Type: Surrogate Endpoint (SUR)
Study 11132612 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 11132612 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 9113185 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 27474536 — Biomarker: TP53
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: p53; LFS1
Study 21988742 — Biomarker: Interleukin 6
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: IL6; IFNB2
Study 24859410 — Biomarker: Serum calcium
Type: Surrogate Endpoint (SUR)
Study 10632415 — Biomarker: Endothelin-1
Type: Safety Biomarker (SAF); Monitoring Biomarker (MOI)
Genes: EDN1
Study 3082287 — Biomarker: TAOK2 mRNA
Type: Predictive Biomarker (PRD)
Genes: TAOK2; KIAA0881; MAP3K17; PSK; PSK1; UNQ2971/PRO7431
Study 18234488 — Biomarker: KIT mRNA
Type: Predictive Biomarker (PRD)
Genes: KIT; SCFR
Study 10100554 — Biomarker: CD34 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD34
Study 7091024 — Biomarker: HP mRNA
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: HP
Study 27605086 — Biomarker: TP53
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: p53; LFS1
Study 23380230 — Biomarker: Hyaluronic acid
Type: Safety Biomarker (SAF)
Study 2375945 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 1096218 — Biomarker: Homovanillic acid
Type: Pharmacodynamic Biomarker (PDY)
Study 31049747 — Biomarker: Serum creatinine
Type: Surrogate Endpoint (SUR)
Study 21504334 — Biomarker: Dipeptidyl peptidase 4
Type: Pharmacodynamic Biomarker (PDY)
Genes: DPP4; ADCP2; CD26
Study 31547752 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 23442371 — Biomarker: Aminopeptidase N
Type: Safety Biomarker (SAF)
Genes: ANPEP; APN; CD13; PEPN
Study 23442371 — Biomarker: High density lipoprotein cholesterol
Type: Pharmacodynamic Biomarker (PDY)
Study 23442371 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 19749496 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 16802360 — Biomarker: Bone mineral density
Type: Surrogate Endpoint (SUR)
Study 9305226 — Biomarker: Intercellular adhesion molecule 1
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: ICAM1
Study 29307660 — Biomarker: Serum calcium
Type: Surrogate Endpoint (SUR)
Study 23000961 — Biomarker: Cystatin C
Type: Safety Biomarker (SAF)
Genes: CST3
Study 12695418 — Biomarker: PDE5A mRNA
Type: Predictive Biomarker (PRD)
Genes: PDE5A; PDE5
Study 29699885 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 29699885 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 20091486 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 26775477 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 18046226 — Biomarker: AMD1 mRNA
Type: Predictive Biomarker (PRD)
Genes: AMD1; AMD
Study 15501952 — Biomarker: Pathological complete response
Type: Surrogate Endpoint (SUR)
Study 3148366 — Biomarker: TRH mRNA
Type: Predictive Biomarker (PRD)
Genes: TRH
Study 25234648 — Biomarker: Neutralizing antibody
Type: Surrogate Endpoint (SUR)
Study 10746426 — Biomarker: Bone mineral density
Type: Surrogate Endpoint (SUR)
Study 8636828 — Biomarker: Forced vital capacity
Type: Surrogate Endpoint (SUR)
Study 27515419 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 12005317 — Biomarker: NF1 mRNA
Type: Predictive Biomarker (PRD)
Genes: NF1
Study 24696507 — Biomarker: AGER mRNA
Type: Predictive Biomarker (PRD)
Genes: AGER; RAGE
Study 20203165 — Biomarker: Beta-2-microglobulin
Type: Safety Biomarker (SAF)
Genes: B2M; CDABP0092; HDCMA22P
Study 20203165 — Biomarker: Serum albumin
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY)
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 20203165 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 15297165 — Biomarker: Cervical intraepithelial neoplasia
Type: Surrogate Endpoint (SUR)
Study 8206772 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 30882244 — Biomarker: DBH mRNA
Type: Predictive Biomarker (PRD)
Genes: DBH
Study 30882244 — Biomarker: TH mRNA
Type: Predictive Biomarker (PRD)
Genes: TH; TYH
Study 30882244 — Biomarker: Interleukin 10
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: IL10
Study 28838366 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 25223696 — Biomarker: Apolipoprotein E
Type: Predictive Biomarker (PRD)
Genes: APOE
Study 16060912 — Biomarker: FH mRNA
Type: Predictive Biomarker (PRD)
Genes: FH
Study 10599554 — Biomarker: Bone mineral density
Type: Surrogate Endpoint (SUR)
Study 8541006 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 2024543 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 2024543 — Biomarker: Serum creatinine
Type: Surrogate Endpoint (SUR)
Study 2024543 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 6168856 — Biomarker: HR mRNA
Type: Predictive Biomarker (PRD)
Genes: HR
Study 6168856 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 26975533 — Biomarker: Free fatty acids
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY)
Study 20639832 — Biomarker: AGA mRNA
Type: Predictive Biomarker (PRD)
Genes: AGA
Study 15821100 — Biomarker: HES1 mRNA
Type: Predictive Biomarker (PRD)
Genes: HES1; BHLHB39; HL; HRY
Study 11909567 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 29100550 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 29100550 — Biomarker: Exhaled carbon monoxide
Type: Surrogate Endpoint (SUR)
Study 20663491 — Biomarker: KLK3 mRNA
Type: Predictive Biomarker (PRD)
Genes: KLK3; APS
Study 15785218 — Biomarker: Forced vital capacity
Type: Surrogate Endpoint (SUR)
Study 30958058 — Biomarker: Interleukin 1
Type: Safety Biomarker (SAF)
Study 9159735 — Biomarker: Huntingtin
Type: Pharmacodynamic Biomarker (PDY)
Genes: HTT; HD; IT15
Study 8267111 — Biomarker: Nerve growth factor
Type: Predictive Biomarker (PRD)
Genes: NGF; NGFB
Study 3115131 — Biomarker: TPR mRNA
Type: Predictive Biomarker (PRD)
Genes: TPR
Study 25420434 — Biomarker: Cervical intraepithelial neoplasia
Type: Surrogate Endpoint (SUR)
Study 21716318 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 18703471 — Biomarker: MB mRNA
Type: Predictive Biomarker (PRD)
Genes: MB
Study 15615822 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 15615822 — Biomarker: Serum creatinine
Type: Surrogate Endpoint (SUR)
Study 30132821 — Biomarker: Forced vital capacity
Type: Surrogate Endpoint (SUR)
Study 9773139 — Biomarker: Natriuretic peptides A
Type: Safety Biomarker (SAF)
Genes: NPPA; ANP; PND
Study 9773139 — Biomarker: Endothelin-1
Type: Safety Biomarker (SAF); Monitoring Biomarker (MOI)
Genes: EDN1
Study 29057618 — Biomarker: PCSK9 mRNA
Type: Predictive Biomarker (PRD)
Genes: PCSK9; NARC1; PSEC0052
Study 15593038 — Biomarker: EPX mRNA
Type: Predictive Biomarker (PRD)
Genes: EPX; EPER; EPO; EPP
Study 28040692 — Biomarker: KRAS mRNA
Type: Predictive Biomarker (PRD)
Genes: KRAS; KRAS2; RASK2
Study 21407110 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 21407110 — Biomarker: Interleukin 10
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: IL10
Study 21407110 — Biomarker: IL-6 and IL-10
Type: Safety Biomarker (SAF)