AIM-Harvard/TrialPanorama-filtered huggingface dataset:
Study 22865902 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 22865902 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 17680909 — Biomarker: Immunoglobulin E
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Study 9757887 — Biomarker: VIP mRNA
Type: Predictive Biomarker (PRD)
Genes: VIP
Study 25125488 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 8764356 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 2063855 — Biomarker: Serum creatinine
Type: Surrogate Endpoint (SUR)
Study 2063855 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 24998880 — Biomarker: FEV mRNA
Type: Predictive Biomarker (PRD)
Genes: FEV; PET1
Study 20436354 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 20436354 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 20436354 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 10730228 — Biomarker: AMD1 mRNA
Type: Predictive Biomarker (PRD)
Genes: AMD1; AMD
Study 8931411 — Biomarker: HBV DNA
Type: Monitoring Biomarker (MOI)
Study 29583081 — Biomarker: TG mRNA
Type: Predictive Biomarker (PRD)
Genes: TG
Study 29583081 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 21568143 — Biomarker: EVL mRNA
Type: Predictive Biomarker (PRD)
Genes: EVL; RNB6
Study 10355414 — Biomarker: von Willebrand factor
Type: Safety Biomarker (SAF)
Genes: VWF; F8VWF
Study 11163738 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 11163738 — Biomarker: Endothelin-1
Type: Safety Biomarker (SAF); Monitoring Biomarker (MOI)
Genes: EDN1
Study 9052467 — Biomarker: PVR mRNA
Type: Predictive Biomarker (PRD)
Genes: PVR; PVS
Study 20516031 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 16092581 — Biomarker: White blood cell
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Study 12585148 — Biomarker: CGA mRNA
Type: Predictive Biomarker (PRD)
Genes: CGA
Study 12585148 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 30971236 — Biomarker: FECH mRNA
Type: Predictive Biomarker (PRD)
Genes: FECH
Study 11300446 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 24625229 — Biomarker: Hyaluronic acid
Type: Safety Biomarker (SAF)
Study 1526683 — Biomarker: CD4 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD4
Study 18069598 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 7070229 — Biomarker: Homovanillic acid
Type: Pharmacodynamic Biomarker (PDY)
Study 19398463 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 19638921 — Biomarker: PYY mRNA
Type: Predictive Biomarker (PRD)
Genes: PYY
Study 11022827 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 9002496 — Biomarker: Serum uric acid
Type: Surrogate Endpoint (SUR)
Study 28610945 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 29193711 — Biomarker: GAD1 mRNA
Type: Predictive Biomarker (PRD)
Genes: GAD1; GAD; GAD67
Study 26218934 — Biomarker: LBP mRNA
Type: Predictive Biomarker (PRD)
Genes: LBP
Study 22801961 — Biomarker: Myeloid cell surface antigen CD33
Type: Predictive Biomarker (PRD)
Genes: CD33; SIGLEC3
Study 1378116 — Biomarker: MBP mRNA
Type: Predictive Biomarker (PRD)
Genes: MBP
Study 1378116 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 19260323 — Biomarker: von Willebrand factor
Type: Safety Biomarker (SAF)
Genes: VWF; F8VWF
Study 15870588 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 1614196 — Biomarker: von Willebrand factor
Type: Safety Biomarker (SAF)
Genes: VWF; F8VWF
Study 30335070 — Biomarker: Superoxide dismutase Cu-Zn
Type: Pharmacodynamic Biomarker (PDY)
Genes: SOD1
Study 8783774 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 1629891 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 6148867 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 30284586 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 25876348 — Biomarker: IL4
Type: Safety Biomarker (SAF)
Genes: BSF1; IL-4; BCGF1; BCGF-1; MGC79402
Study 25876348 — Biomarker: Immunoglobulin E
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Study 18781486 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 18781486 — Biomarker: Intercellular adhesion molecule 1
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: ICAM1
Study 12904084 — Biomarker: CD34 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD34
Study 9414541 — Biomarker: NPEPPS mRNA
Type: Predictive Biomarker (PRD)
Genes: NPEPPS; PSA
Study 8017473 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 8017473 — Biomarker: High density lipoprotein cholesterol
Type: Pharmacodynamic Biomarker (PDY)
Study 31408838 — Biomarker: Apolipoprotein E
Type: Predictive Biomarker (PRD)
Genes: APOE
Study 27462804 — Biomarker: DMD
Type: Predictive Biomarker (PRD)
Genes: BMD; DXS142; DXS164; DXS206; DXS230; DXS239; DXS268; DXS269; DXS270; DXS272
Study 27462804 — Biomarker: Bone mineral density
Type: Surrogate Endpoint (SUR)
Study 23819224 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 25605862 — Biomarker: Erbb2 tyrosine kinase receptor
Type: Predictive Biomarker (PRD)
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 23668423 — Biomarker: High density lipoprotein cholesterol
Type: Pharmacodynamic Biomarker (PDY)
Study 12575552 — Biomarker: Carcinoembryonic antigen CEA
Type: Monitoring Biomarker (MOI)
Genes: CEACAM5; CEA
Study 12575552 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 8162926 — Biomarker: Heat pain threshold
Type: Pharmacodynamic Biomarker (PDY)
Study 8162926 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 31179316 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 11065222 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 25707083 — Biomarker: HP mRNA
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: HP
Study 10588611 — Biomarker: Reactive oxygen species
Type: Safety Biomarker (SAF)
Study 6765920 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 12750578 — Biomarker: Bone mineral density
Type: Surrogate Endpoint (SUR)
Study 10722768 — Biomarker: Forced vital capacity
Type: Surrogate Endpoint (SUR)
Study 3798420 — Biomarker: Antithrombin-III
Type: Safety Biomarker (SAF)
Genes: SERPINC1; AT3; PRO0309
Study 3798420 — Biomarker: D-dimer
Type: Safety Biomarker (SAF); Monitoring Biomarker (MOI)
Study 16173886 — Biomarker: CPM mRNA
Type: Predictive Biomarker (PRD)
Genes: CPM
Study 15624040 — Biomarker: C-C motif chemokine 2
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CCL2; MCP1; SCYA2
Study 15624040 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 11715353 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 11715353 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 11715353 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 3619222 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 23866725 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 11049909 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 3898418 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 26996246 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 26286610 — Biomarker: CAP1 mRNA
Type: Predictive Biomarker (PRD)
Genes: CAP1; CAP
Study 17408389 — Biomarker: PVR mRNA
Type: Predictive Biomarker (PRD)
Genes: PVR; PVS
Study 31439584 — Biomarker: Epidermal growth factor receptor
Type: Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: EGFR; ERBB; ERBB1; HER1
Study 25664051 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 20125103 — Biomarker: PYY mRNA
Type: Predictive Biomarker (PRD)
Genes: PYY
Study 1959515 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 31099485 — Biomarker: Forced vital capacity
Type: Surrogate Endpoint (SUR)
Study 7752591 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 7752591 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 1800749 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 6356326 — Biomarker: VIP mRNA
Type: Predictive Biomarker (PRD)
Genes: VIP
Study 31727580 — Biomarker: CD4 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD4
Study 31240811 — Biomarker: Exhaled carbon monoxide
Type: Surrogate Endpoint (SUR)
Study 25273547 — Biomarker: SCD mRNA
Type: Predictive Biomarker (PRD)
Genes: SCD; FADS5; SCD1; SCDOS
Study 23783097 — Biomarker: CCK mRNA
Type: Predictive Biomarker (PRD)
Genes: CCK
Study 23783097 — Biomarker: Fibroblast growth factor 19
Type: Pharmacodynamic Biomarker (PDY)
Genes: FGF19; UNQ334/PRO533
Study 23783097 — Biomarker: FGF21 mRNA
Type: Predictive Biomarker (PRD)
Genes: FGF21; UNQ3115/PRO10196
Study 2975228 — Biomarker: Forced vital capacity
Type: Surrogate Endpoint (SUR)
Study 18793563 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 3032827 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 29447076 — Biomarker: CP mRNA
Type: Predictive Biomarker (PRD)
Genes: CP
Study 22998182 — Biomarker: NPEPPS mRNA
Type: Predictive Biomarker (PRD)
Genes: NPEPPS; PSA
Study 20003398 — Biomarker: MCIDAS mRNA
Type: Predictive Biomarker (PRD)
Genes: MCIDAS; IDAS; MCI; MCIN
Study 28211216 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 24063830 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 24063830 — Biomarker: High density lipoprotein cholesterol
Type: Pharmacodynamic Biomarker (PDY)
Study 24816725 — Biomarker: TLR9
Type: Predictive Biomarker (PRD)
Genes: CD289
Study 22288389 — Biomarker: Matrix metalloproteinase 1
Type: Monitoring Biomarker (MOI)
Genes: MMP1; CLG
Study 12131543 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 7010529 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 30644838 — Biomarker: FXYD1 mRNA
Type: Predictive Biomarker (PRD)
Genes: FXYD1; PLM
Study 3356083 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 28737966 — Biomarker: Exhaled nitric oxide
Type: Predictive Biomarker (PRD)
Study 26694228 — Biomarker: 5'-AMP-activated protein kinase subunit beta-1
Type: Pharmacodynamic Biomarker (PDY)
Genes: PRKAB1; AMPK
Study 22791090 — Biomarker: Interleukin 6
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: IL6; IFNB2
Study 22791090 — Biomarker: IL6
Type: Predictive Biomarker (PRD)
Genes: IL-6; BSF2; HGF; HSF
Study 22791090 — Biomarker: Interleukin 8
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: CXCL8; IL8
Study 22791090 — Biomarker: Interleukin 10
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: IL10
Study 22791090 — Biomarker: D-dimer
Type: Safety Biomarker (SAF); Monitoring Biomarker (MOI)
Study 11095440 — Biomarker: Bone mineral density
Type: Surrogate Endpoint (SUR)
Study 8820895 — Biomarker: Natriuretic peptides A
Type: Safety Biomarker (SAF)
Genes: NPPA; ANP; PND
Study 8820895 — Biomarker: B-type natriuretic peptide
Type: Safety Biomarker (SAF)
Genes: NPPB
Study 11907418 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 1964580 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 1964580 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 22570108 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 18946418 — Biomarker: D-dimer
Type: Safety Biomarker (SAF); Monitoring Biomarker (MOI)
Study 14713377 — Biomarker: DCD mRNA
Type: Predictive Biomarker (PRD)
Genes: DCD; AIDD; DSEP
Study 31975558 — Biomarker: NLRP3 mRNA
Type: Predictive Biomarker (PRD)
Genes: NLRP3; C1orf7; CIAS1; NALP3; PYPAF1
Study 31975558 — Biomarker: PINK1 mRNA
Type: Predictive Biomarker (PRD)
Genes: PINK1
Study 31975558 — Biomarker: LAMP2 mRNA
Type: Predictive Biomarker (PRD)
Genes: LAMP2
Study 15983524 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 8866563 — Biomarker: SI mRNA
Type: Predictive Biomarker (PRD)
Genes: SI
Study 24650336 — Biomarker: IK mRNA
Type: Predictive Biomarker (PRD)
Genes: IK; RED; RER
Study 12123409 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 29788791 — Biomarker: CYP2A6 mRNA
Type: Predictive Biomarker (PRD)
Genes: CYP2A6; CYP2A3
Study 22680238 — Biomarker: HR mRNA
Type: Predictive Biomarker (PRD)
Genes: HR
Study 22680238 — Biomarker: SELENBP1 mRNA
Type: Predictive Biomarker (PRD)
Genes: SELENBP1; SBP
Study 22680238 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 15818694 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 12463111 — Biomarker: Plasminogen activator inhibitor
Type: Safety Biomarker (SAF)
Genes: SERPINE1; PAI1; PLANH1
Study 12463111 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 8880373 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 27445317 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 27445317 — Biomarker: Interleukin 2
Type: Safety Biomarker (SAF)
Genes: IL2
Study 7656458 — Biomarker: Complement C3
Type: Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: C3; CPAMD1
Study 31557945 — Biomarker: CHAF1A mRNA
Type: Predictive Biomarker (PRD)
Genes: CHAF1A; CAF; CAF1P150
Study 31557945 — Biomarker: RPE mRNA
Type: Predictive Biomarker (PRD)
Genes: RPE; HUSSY-17
Study 28641153 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 15850317 — Biomarker: MB mRNA
Type: Predictive Biomarker (PRD)
Genes: MB
Study 30514196 — Biomarker: Serum calcium
Type: Surrogate Endpoint (SUR)
Study 25968593 — Biomarker: Natriuretic peptides A
Type: Safety Biomarker (SAF)
Genes: NPPA; ANP; PND
Study 25968593 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 17239474 — Biomarker: Coagulation factor IIa
Type: Safety Biomarker (SAF)
Genes: F2
Study 14963058 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 14963058 — Biomarker: High density lipoprotein cholesterol
Type: Pharmacodynamic Biomarker (PDY)
Study 11758227 — Biomarker: PC mRNA
Type: Predictive Biomarker (PRD)
Genes: PC
Study 11758227 — Biomarker: APC mRNA
Type: Predictive Biomarker (PRD)
Genes: APC; DP2.5
Study 9412880 — Biomarker: TAT mRNA
Type: Predictive Biomarker (PRD)
Genes: TAT
Study 9412880 — Biomarker: REG3A mRNA
Type: Predictive Biomarker (PRD)
Genes: REG3A; HIP; PAP; PAP1
Study 9412880 — Biomarker: Antithrombin-III
Type: Safety Biomarker (SAF)
Genes: SERPINC1; AT3; PRO0309
Study 31246234 — Biomarker: Bone mineral density
Type: Surrogate Endpoint (SUR)
Study 30466438 — Biomarker: PYY mRNA
Type: Predictive Biomarker (PRD)
Genes: PYY
Study 26894653 — Biomarker: Serum creatinine
Type: Surrogate Endpoint (SUR)
Study 26894653 — Biomarker: Serum uric acid
Type: Surrogate Endpoint (SUR)
Study 24876915 — Biomarker: CAT mRNA
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: CAT
Study 24876915 — Biomarker: GPX1 mRNA
Type: Predictive Biomarker (PRD)
Genes: GPX1
Study 24876915 — Biomarker: SOD2 mRNA
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: SOD2
Study 24876915 — Biomarker: SIRT2 mRNA
Type: Predictive Biomarker (PRD)
Genes: SIRT2; SIR2L; SIR2L2
Study 24876915 — Biomarker: T-cell specific protein RANTES
Type: Safety Biomarker (SAF)
Genes: CCL5; D17S136E; SCYA5
Study 23338259 — Biomarker: CLSTN3 mRNA
Type: Predictive Biomarker (PRD)
Genes: CLSTN3; CS3; KIAA0726
Study 23338259 — Biomarker: CLIC1 mRNA
Type: Predictive Biomarker (PRD)
Genes: CLIC1; G6; NCC27
Study 15640324 — Biomarker: Exhaled nitric oxide
Type: Predictive Biomarker (PRD)
Study 1369702 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 31198477 — Biomarker: KNG1 mRNA
Type: Predictive Biomarker (PRD)
Genes: KNG1; BDK; KNG
Study 20180356 — Biomarker: Serum alkaline phosphatase
Type: Surrogate Endpoint (SUR)
Study 16540851 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 11680666 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 11680666 — Biomarker: Serum potassium
Type: Surrogate Endpoint (SUR)
Study 11680666 — Biomarker: Serum uric acid
Type: Surrogate Endpoint (SUR)
Study 9270666 — Biomarker: Succinate dehydrogenase
Type: Safety Biomarker (SAF)
Genes: SDHD
Study 2454360 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 30430875 — Biomarker: Coagulation factor IIa
Type: Safety Biomarker (SAF)
Genes: F2
Study 22538054 — Biomarker: CYP3A4 mRNA
Type: Predictive Biomarker (PRD)
Genes: CYP3A4; CYP3A3
Study 19640853 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 19640853 — Biomarker: High density lipoprotein cholesterol
Type: Pharmacodynamic Biomarker (PDY)
Study 23372114 — Biomarker: CD4 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD4
Study 10926339 — Biomarker: Eosinophil cationic protein
Type: Safety Biomarker (SAF)
Genes: RNASE3; ECP; RNS3
Study 10926339 — Biomarker: EPX mRNA
Type: Predictive Biomarker (PRD)
Genes: EPX; EPER; EPO; EPP
Study 4017661 — Biomarker: Serum albumin
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY)
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 22251615 — Biomarker: Bone mineral density
Type: Surrogate Endpoint (SUR)
Study 12595513 — Biomarker: Serum creatinine
Type: Surrogate Endpoint (SUR)
Study 1547164 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 21438849 — Biomarker: UGT2B7 mRNA
Type: Predictive Biomarker (PRD)
Genes: UGT2B7; UGTB2B9
Study 15298426 — Biomarker: Myeloperoxidase
Type: Safety Biomarker (SAF)
Genes: MPO
Study 15298426 — Biomarker: TAT mRNA
Type: Predictive Biomarker (PRD)
Genes: TAT
Study 2857602 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 22521214 — Biomarker: PON1 mRNA
Type: Predictive Biomarker (PRD)
Genes: PON1; PON
Study 12830007 — Biomarker: Serum creatinine
Type: Surrogate Endpoint (SUR)
Study 1338584 — Biomarker: Cytochrome c
Type: Safety Biomarker (SAF)
Study 20978525 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 20978525 — Biomarker: Plasminogen activator inhibitor
Type: Safety Biomarker (SAF)
Genes: SERPINE1; PAI1; PLANH1
Study 20158691 — Biomarker: Bone mineral density
Type: Surrogate Endpoint (SUR)
Study 361345 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 31257404 — Biomarker: Beta-2-microglobulin
Type: Safety Biomarker (SAF)
Genes: B2M; CDABP0092; HDCMA22P
Study 23786776 — Biomarker: Cytochrome P450 2D6
Type: Safety Biomarker (SAF)
Genes: CYP2D6; CYP2DL1
Study 23786776 — Biomarker: SHBG mRNA
Type: Predictive Biomarker (PRD)
Genes: SHBG
Study 23786776 — Biomarker: Estrogen receptor
Type: Predictive Biomarker (PRD)
Genes: ESR1; ESR; NR3A1
Study 23786776 — Biomarker: Ki-67
Type: Predictive Biomarker (PRD)
Genes: MKI67; MIB-1; PPP1R105
Study 23786776 — Biomarker: Antithrombin-III
Type: Safety Biomarker (SAF)
Genes: SERPINC1; AT3; PRO0309
Study 30524424 — Biomarker: EPX mRNA
Type: Predictive Biomarker (PRD)
Genes: EPX; EPER; EPO; EPP
Study 24381088 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 23106890 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 1986564 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 27498129 — Biomarker: Erbb2 tyrosine kinase receptor
Type: Predictive Biomarker (PRD)
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 20887414 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 18541827 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 6135908 — Biomarker: GNRH1 mRNA
Type: Predictive Biomarker (PRD)
Genes: GNRH1; GNRH; GRH; LHRH
Study 6135908 — Biomarker: Plasma testosterone level
Type: Surrogate Endpoint (SUR)
Study 30811282 — Biomarker: NPEPPS mRNA
Type: Predictive Biomarker (PRD)
Genes: NPEPPS; PSA
Study 30811282 — Biomarker: KCNH2 mRNA
Type: Predictive Biomarker (PRD)
Genes: KCNH2; ERG; ERG1; HERG
Study 30811282 — Biomarker: Phosphatase and tensin homolog
Type: Predictive Biomarker (PRD)
Genes: PTEN; MMAC1; TEP1
Study 19621708 — Biomarker: HBV DNA
Type: Monitoring Biomarker (MOI)
Study 9543364 — Biomarker: Serum creatinine
Type: Surrogate Endpoint (SUR)
Study 3291099 — Biomarker: Serum alkaline phosphatase
Type: Surrogate Endpoint (SUR)
Study 8153915 — Biomarker: Forced vital capacity
Type: Surrogate Endpoint (SUR)
Study 31479537 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 30346655 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 22314671 — Biomarker: Forced vital capacity
Type: Surrogate Endpoint (SUR)
Study 12665158 — Biomarker: Cytochrome P450 2D6
Type: Safety Biomarker (SAF)
Genes: CYP2D6; CYP2DL1
Study 8400972 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 31654548 — Biomarker: von Willebrand factor
Type: Safety Biomarker (SAF)
Genes: VWF; F8VWF
Study 20354496 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 20354496 — Biomarker: Interleukin 6
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: IL6; IFNB2
Study 20354496 — Biomarker: IL6
Type: Predictive Biomarker (PRD)
Genes: IL-6; BSF2; HGF; HSF
Study 20354496 — Biomarker: Interleukin 10
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: IL10
Study 20354496 — Biomarker: Cardiac troponin I
Type: Safety Biomarker (SAF)
Genes: TNNI3; TNNC1
Study 20354496 — Biomarker: IL-6 and IL-10
Type: Safety Biomarker (SAF)
Study 18207289 — Biomarker: Neutralizing antibody
Type: Surrogate Endpoint (SUR)
Study 6355421 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 3987782 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 26401779 — Biomarker: Apolipoprotein E
Type: Predictive Biomarker (PRD)
Genes: APOE
Study 21426747 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 31515632 — Biomarker: HR mRNA
Type: Predictive Biomarker (PRD)
Genes: HR
Study 31515632 — Biomarker: HGS mRNA
Type: Predictive Biomarker (PRD)
Genes: HGS; HRS
Study 29772028 — Biomarker: SH2D1A mRNA
Type: Predictive Biomarker (PRD)
Genes: SH2D1A; DSHP; SAP
Study 16647134 — Biomarker: Vascular endothelial growth factor A
Type: Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: VEGFA; VEGF
Study 16647134 — Biomarker: Vascular endothelial growth factor
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY)
Study 10731545 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)