AIM-Harvard/TrialPanorama-filtered huggingface dataset:
Study 19328268 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 11046101 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 9333103 — Biomarker: Cytochrome P450 2C19
Type: Safety Biomarker (SAF)
Genes: CYP2C19
Study 23100282 — Biomarker: CELSR2 mRNA
Type: Predictive Biomarker (PRD)
Genes: CELSR2; CDHF10; EGFL2; KIAA0279; MEGF3
Study 23100282 — Biomarker: PSRC1 mRNA
Type: Predictive Biomarker (PRD)
Genes: PSRC1; DDA3; FP3214
Study 23100282 — Biomarker: SORT1 mRNA
Type: Predictive Biomarker (PRD)
Genes: SORT1
Study 23100282 — Biomarker: MRP2
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: ABCC2; DJS; cMRP
Study 23100282 — Biomarker: Apolipoprotein E
Type: Predictive Biomarker (PRD)
Genes: APOE
Study 23100282 — Biomarker: SLCO1B1 mRNA
Type: Predictive Biomarker (PRD)
Genes: SLCO1B1; LST1; OATP1B1; OATP2; OATPC; SLC21A6
Study 18647814 — Biomarker: CCK mRNA
Type: Predictive Biomarker (PRD)
Genes: CCK
Study 18647814 — Biomarker: PYY mRNA
Type: Predictive Biomarker (PRD)
Genes: PYY
Study 10675071 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 10675071 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 30529836 — Biomarker: Mismatch negativity
Type: Pharmacodynamic Biomarker (PDY)
Study 23532306 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 22152650 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 22152650 — Biomarker: Serum uric acid
Type: Surrogate Endpoint (SUR)
Study 19013235 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 15047035 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 12501759 — Biomarker: CD69 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD69; CLEC2C
Study 9798587 — Biomarker: CD4 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD4
Study 23665965 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 15280342 — Biomarker: BRCA1 mRNA
Type: Predictive Biomarker (PRD)
Genes: BRCA1; RNF53
Study 15280342 — Biomarker: BRCA2 mRNA
Type: Predictive Biomarker (PRD)
Genes: BRCA2; FACD; FANCD1
Study 11204586 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 11204586 — Biomarker: von Willebrand factor
Type: Safety Biomarker (SAF)
Genes: VWF; F8VWF
Study 11204586 — Biomarker: D-dimer
Type: Safety Biomarker (SAF); Monitoring Biomarker (MOI)
Study 9458824 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 2973132 — Biomarker: LBP mRNA
Type: Predictive Biomarker (PRD)
Genes: LBP
Study 28786220 — Biomarker: PC mRNA
Type: Predictive Biomarker (PRD)
Genes: PC
Study 11349388 — Biomarker: LARS1 mRNA
Type: Predictive Biomarker (PRD)
Genes: LARS1; KIAA1352; LARS
Study 9203655 — Biomarker: Interferon gamma
Type: Safety Biomarker (SAF); Monitoring Biomarker (MOI)
Genes: IFNG
Study 7960505 — Biomarker: TAT mRNA
Type: Predictive Biomarker (PRD)
Genes: TAT
Study 7960505 — Biomarker: Antithrombin-III
Type: Safety Biomarker (SAF)
Genes: SERPINC1; AT3; PRO0309
Study 7960505 — Biomarker: Plasminogen activator inhibitor
Type: Safety Biomarker (SAF)
Genes: SERPINE1; PAI1; PLANH1
Study 7960505 — Biomarker: D-dimer
Type: Safety Biomarker (SAF); Monitoring Biomarker (MOI)
Study 29248711 — Biomarker: TKT mRNA
Type: Predictive Biomarker (PRD)
Genes: TKT
Study 9416930 — Biomarker: DDR1 mRNA
Type: Predictive Biomarker (PRD)
Genes: DDR1; CAK; EDDR1; NEP; NTRK4; PTK3A; RTK6; TRKE
Study 9416930 — Biomarker: Intercellular adhesion molecule 1
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: ICAM1
Study 30598522 — Biomarker: miR-150
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: MIR150
Study 30598522 — Biomarker: miR-15a
Type: Safety Biomarker (SAF)
Genes: MIR15A
Study 30598522 — Biomarker: miR-375
Type: Safety Biomarker (SAF)
Genes: MIR375
Study 30598522 — Biomarker: miR-30a-5p
Type: Safety Biomarker (SAF)
Genes: MIR30A
Study 3513269 — Biomarker: RPE mRNA
Type: Predictive Biomarker (PRD)
Genes: RPE; HUSSY-17
Study 18837799 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 10931123 — Biomarker: Eosinophil cationic protein
Type: Safety Biomarker (SAF)
Genes: RNASE3; ECP; RNS3
Study 2942844 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 9661091 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 23439744 — Biomarker: Dipeptidyl peptidase 4
Type: Pharmacodynamic Biomarker (PDY)
Genes: DPP4; ADCP2; CD26
Study 23439744 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 8380131 — Biomarker: CAP1 mRNA
Type: Predictive Biomarker (PRD)
Genes: CAP1; CAP
Study 31074654 — Biomarker: SLC2A4 mRNA
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: SLC2A4; GLUT4
Study 30684325 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 30684325 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 30684325 — Biomarker: Interleukin 6
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: IL6; IFNB2
Study 241600 — Biomarker: Serum uric acid
Type: Surrogate Endpoint (SUR)
Study 29313279 — Biomarker: BRCA1 mRNA
Type: Predictive Biomarker (PRD)
Genes: BRCA1; RNF53
Study 29313279 — Biomarker: BRCA2 mRNA
Type: Predictive Biomarker (PRD)
Genes: BRCA2; FACD; FANCD1
Study 29313279 — Biomarker: Homologous recombination deficiency
Type: Predictive Biomarker (PRD)
Study 16137951 — Biomarker: Bone mineral density
Type: Surrogate Endpoint (SUR)
Study 30297258 — Biomarker: CIT mRNA
Type: Predictive Biomarker (PRD)
Genes: CIT; CRIK; KIAA0949; STK21
Study 20593910 — Biomarker: Valproic acid
Type: Pharmacodynamic Biomarker (PDY)
Study 10588452 — Biomarker: GAD1 mRNA
Type: Predictive Biomarker (PRD)
Genes: GAD1; GAD; GAD67
Study 10588452 — Biomarker: GAD2 mRNA
Type: Predictive Biomarker (PRD)
Genes: GAD2; GAD65
Study 10588452 — Biomarker: HLA-DQB1
Type: Safety Biomarker (SAF)
Genes: IDDM1; CELIAC1
Study 31267366 — Biomarker: LAMA1 mRNA
Type: Predictive Biomarker (PRD)
Genes: LAMA1; LAMA
Study 17699311 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 31298927 — Biomarker: OAT mRNA
Type: Predictive Biomarker (PRD)
Genes: OAT
Study 18198311 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 18198311 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 9101424 — Biomarker: PC mRNA
Type: Predictive Biomarker (PRD)
Genes: PC
Study 21998703 — Biomarker: CD4 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD4
Study 9284985 — Biomarker: ALK tyrosine kinase receptor
Type: Predictive Biomarker (PRD)
Genes: ALK
Study 8367775 — Biomarker: SFPQ mRNA
Type: Predictive Biomarker (PRD)
Genes: SFPQ; PSF
Study 24521021 — Biomarker: Neutrophil gelatinase-associated lipocalin
Type: Safety Biomarker (SAF); Monitoring Biomarker (MOI)
Genes: LCN2; HNL; NGAL
Study 20510247 — Biomarker: Intercellular adhesion molecule 1
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: ICAM1
Study 20510247 — Biomarker: IL-6 and IL-10
Type: Safety Biomarker (SAF)
Study 10910856 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 3924617 — Biomarker: TNS1 mRNA
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: TNS1; TNS
Study 30908082 — Biomarker: IL1R2 mRNA
Type: Predictive Biomarker (PRD)
Genes: IL1R2; IL1RB
Study 30908082 — Biomarker: ITGB3 mRNA
Type: Predictive Biomarker (PRD)
Genes: ITGB3; GP3A
Study 30908082 — Biomarker: CAVIN2 mRNA
Type: Predictive Biomarker (PRD)
Genes: CAVIN2; SDPR
Study 30908082 — Biomarker: FKBP5 mRNA
Type: Predictive Biomarker (PRD); Monitoring Biomarker (MOI)
Genes: FKBP5; AIG6; FKBP51
Study 30908082 — Biomarker: ZBTB16 mRNA
Type: Predictive Biomarker (PRD)
Genes: ZBTB16; PLZF; ZNF145
Study 30908082 — Biomarker: DDIT4 mRNA
Type: Predictive Biomarker (PRD)
Genes: DDIT4; REDD1; RTP801
Study 26016363 — Biomarker: Endothelin-1
Type: Safety Biomarker (SAF); Monitoring Biomarker (MOI)
Genes: EDN1
Study 28929560 — Biomarker: Matrix metalloproteinase 9
Type: Pharmacodynamic Biomarker (PDY)
Genes: MMP9; CLG4B
Study 22235821 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 9875835 — Biomarker: CD4 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD4
Study 31796073 — Biomarker: Erbb2 tyrosine kinase receptor
Type: Predictive Biomarker (PRD)
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 31796073 — Biomarker: FCGR3A mRNA
Type: Predictive Biomarker (PRD)
Genes: FCGR3A; CD16A; FCG3; FCGR3; IGFR3
Study 31796073 — Biomarker: HR mRNA
Type: Predictive Biomarker (PRD)
Genes: HR
Study 31796073 — Biomarker: Hormone receptor
Type: Predictive Biomarker (PRD)
Study 27194364 — Biomarker: Probing pocket depth
Type: Surrogate Endpoint (SUR)
Study 26027861 — Biomarker: LPO mRNA
Type: Predictive Biomarker (PRD)
Genes: LPO; SAPX
Study 26027861 — Biomarker: Hyaluronic acid
Type: Safety Biomarker (SAF)
Study 27982478 — Biomarker: Bone mineral density
Type: Surrogate Endpoint (SUR)
Study 12770652 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 8886294 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 23408763 — Biomarker: RBP4 mRNA
Type: Predictive Biomarker (PRD)
Genes: RBP4; PRO2222
Study 23408763 — Biomarker: SHBG mRNA
Type: Predictive Biomarker (PRD)
Genes: SHBG
Study 10942162 — Biomarker: Endothelin-1
Type: Safety Biomarker (SAF); Monitoring Biomarker (MOI)
Genes: EDN1
Study 2994698 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 2994698 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 2994698 — Biomarker: Serum potassium
Type: Surrogate Endpoint (SUR)
Study 26924770 — Biomarker: Neutrophil to lymphocyte
Type: Safety Biomarker (SAF)
Study 24809264 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 24809264 — Biomarker: White blood cell
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Study 24809264 — Biomarker: Serum creatinine
Type: Surrogate Endpoint (SUR)
Study 22340541 — Biomarker: CD4 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD4
Study 22340541 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 22340541 — Biomarker: Interleukin 6
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: IL6; IFNB2
Study 20590759 — Biomarker: White blood cell
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Study 15270789 — Biomarker: AIP mRNA
Type: Predictive Biomarker (PRD)
Genes: AIP; XAP2
Study 9543065 — Biomarker: Granulocyte-macrophage colony-stimulating factor
Type: Safety Biomarker (SAF)
Genes: CSF2; GMCSF
Study 29124324 — Biomarker: CP mRNA
Type: Predictive Biomarker (PRD)
Genes: CP
Study 29124324 — Biomarker: HR mRNA
Type: Predictive Biomarker (PRD)
Genes: HR
Study 16361368 — Biomarker: Estrogen receptor
Type: Predictive Biomarker (PRD)
Genes: ESR1; ESR; NR3A1
Study 31778310 — Biomarker: PGC mRNA
Type: Predictive Biomarker (PRD)
Genes: PGC
Study 31778310 — Biomarker: 5'-AMP-activated protein kinase subunit beta-1
Type: Pharmacodynamic Biomarker (PDY)
Genes: PRKAB1; AMPK
Study 31778310 — Biomarker: Vascular endothelial growth factor A
Type: Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: VEGFA; VEGF
Study 2065411 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 25212745 — Biomarker: ALOX5 mRNA
Type: Predictive Biomarker (PRD)
Genes: ALOX5; LOG5
Study 17164834 — Biomarker: Serum albumin
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY)
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 17164834 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 15886432 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 24887458 — Biomarker: Erbb2 tyrosine kinase receptor
Type: Predictive Biomarker (PRD)
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 26957979 — Biomarker: Serum calcium
Type: Surrogate Endpoint (SUR)
Study 24365779 — Biomarker: OGT mRNA
Type: Predictive Biomarker (PRD)
Genes: OGT
Study 24365779 — Biomarker: Beta-N-acetylhexosaminidase
Type: Safety Biomarker (SAF)
Genes: OGA; HEXC; KIAA0679; MEA5; MGEA5
Study 21480321 — Biomarker: HBV DNA
Type: Monitoring Biomarker (MOI)
Study 10915412 — Biomarker: MB mRNA
Type: Predictive Biomarker (PRD)
Genes: MB
Study 26375942 — Biomarker: Cytochrome P450 2C19
Type: Safety Biomarker (SAF)
Genes: CYP2C19
Study 22650964 — Biomarker: Vitamin B12
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI)
Study 19541525 — Biomarker: NFIC mRNA
Type: Predictive Biomarker (PRD)
Genes: NFIC; NFI
Study 9641172 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 9641172 — Biomarker: Serum creatinine
Type: Surrogate Endpoint (SUR)
Study 9641172 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 9641172 — Biomarker: High density lipoprotein cholesterol
Type: Pharmacodynamic Biomarker (PDY)
Study 29694272 — Biomarker: HR mRNA
Type: Predictive Biomarker (PRD)
Genes: HR
Study 28512184 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 26281833 — Biomarker: CS mRNA
Type: Predictive Biomarker (PRD)
Genes: CS
Study 23530977 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 17942927 — Biomarker: CD4 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD4
Study 7870348 — Biomarker: CPD mRNA
Type: Predictive Biomarker (PRD)
Genes: CPD
Study 7870348 — Biomarker: RAPH1 mRNA
Type: Predictive Biomarker (PRD)
Genes: RAPH1; ALS2CR18; ALS2CR9; KIAA1681; LPD; PREL2; RMO1
Study 28166654 — Biomarker: Hepatocyte growth factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: HGF; HPTA
Study 28166654 — Biomarker: Forced vital capacity
Type: Surrogate Endpoint (SUR)
Study 21931228 — Biomarker: Myeloperoxidase
Type: Safety Biomarker (SAF)
Genes: MPO
Study 16879471 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 12805245 — Biomarker: TG mRNA
Type: Predictive Biomarker (PRD)
Genes: TG
Study 12805245 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 12805245 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 12805245 — Biomarker: High density lipoprotein cholesterol
Type: Pharmacodynamic Biomarker (PDY)
Study 1339712 — Biomarker: MB mRNA
Type: Predictive Biomarker (PRD)
Genes: MB
Study 27355400 — Biomarker: TBXT mRNA
Type: Predictive Biomarker (PRD)
Genes: TBXT; T
Study 26742006 — Biomarker: AR mRNA
Type: Predictive Biomarker (PRD)
Genes: AR; DHTR; NR3C4
Study 16075030 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 16075030 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 10440565 — Biomarker: HR mRNA
Type: Predictive Biomarker (PRD)
Genes: HR
Study 19052048 — Biomarker: Exhaled carbon monoxide
Type: Surrogate Endpoint (SUR)
Study 19052048 — Biomarker: Forced vital capacity
Type: Surrogate Endpoint (SUR)
Study 12236276 — Biomarker: NNT mRNA
Type: Predictive Biomarker (PRD)
Genes: NNT
Study 7813225 — Biomarker: SHBG mRNA
Type: Predictive Biomarker (PRD)
Genes: SHBG
Study 25547237 — Biomarker: CD46 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD46; MCP; MIC10
Study 6716325 — Biomarker: HR mRNA
Type: Predictive Biomarker (PRD)
Genes: HR
Study 10854004 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 1544194 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 16209966 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 31604061 — Biomarker: Hyaluronic acid
Type: Safety Biomarker (SAF)
Study 14971661 — Biomarker: FCGR1A mRNA
Type: Predictive Biomarker (PRD)
Genes: FCGR1A; FCG1; FCGR1; IGFR1
Study 11252686 — Biomarker: Serum creatinine
Type: Surrogate Endpoint (SUR)
Study 16361531 — Biomarker: Estrogen receptor
Type: Predictive Biomarker (PRD)
Genes: ESR1; ESR; NR3A1
Study 4009965 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 18496321 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 24814858 — Biomarker: Vitamin B12
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI)
Study 24422887 — Biomarker: CRHR1 mRNA
Type: Predictive Biomarker (PRD)
Genes: CRHR1; CRFR; CRFR1; CRHR
Study 17349681 — Biomarker: FEV mRNA
Type: Predictive Biomarker (PRD)
Genes: FEV; PET1
Study 11511432 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 11511432 — Biomarker: Endothelin-1
Type: Safety Biomarker (SAF); Monitoring Biomarker (MOI)
Genes: EDN1
Study 27567447 — Biomarker: SLC10A3 mRNA
Type: Predictive Biomarker (PRD)
Genes: SLC10A3; DXS253E; P3
Study 20695686 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 17968001 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 22267390 — Biomarker: PGC mRNA
Type: Predictive Biomarker (PRD)
Genes: PGC
Study 22267390 — Biomarker: 5'-AMP-activated protein kinase subunit beta-1
Type: Pharmacodynamic Biomarker (PDY)
Genes: PRKAB1; AMPK
Study 22267390 — Biomarker: TP53
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: p53; LFS1
Study 22267390 — Biomarker: HSPA1B mRNA
Type: Predictive Biomarker (PRD)
Genes: HSPA1B; HSP72
Study 2455149 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 2455149 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 25937837 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 19035150 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 19035150 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 19035150 — Biomarker: Interleukin 6
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: IL6; IFNB2
Study 17235728 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 14635368 — Biomarker: Cyclic adenosine monophosphate
Type: Pharmacodynamic Biomarker (PDY)
Study 8851907 — Biomarker: CIT mRNA
Type: Predictive Biomarker (PRD)
Genes: CIT; CRIK; KIAA0949; STK21
Study 30580266 — Biomarker: BRCA1 mRNA
Type: Predictive Biomarker (PRD)
Genes: BRCA1; RNF53
Study 25175762 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 17520238 — Biomarker: PPARA mRNA
Type: Predictive Biomarker (PRD)
Genes: PPARA; NR1C1; PPAR
Study 17520238 — Biomarker: 5'-AMP-activated protein kinase subunit beta-1
Type: Pharmacodynamic Biomarker (PDY)
Genes: PRKAB1; AMPK
Study 16361631 — Biomarker: BRCA1 mRNA
Type: Predictive Biomarker (PRD)
Genes: BRCA1; RNF53
Study 10438710 — Biomarker: White blood cell
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Study 2111126 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 2111126 — Biomarker: Interleukin 1
Type: Safety Biomarker (SAF)
Study 29528768 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 29528768 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 29528768 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 29528768 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 12148300 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 28958137 — Biomarker: PIP mRNA
Type: Predictive Biomarker (PRD)
Genes: PIP; GCDFP15; GPIP4
Study 25590507 — Biomarker: CP mRNA
Type: Predictive Biomarker (PRD)
Genes: CP
Study 23235439 — Biomarker: AMD1 mRNA
Type: Predictive Biomarker (PRD)
Genes: AMD1; AMD
Study 15618070 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 26321524 — Biomarker: Hyaluronic acid
Type: Safety Biomarker (SAF)
Study 23301779 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 2468978 — Biomarker: Serum albumin
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY)
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 28079825 — Biomarker: BAG3 mRNA
Type: Predictive Biomarker (PRD)
Genes: BAG3; BIS
Study 21819167 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 17548726 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 30550515 — Biomarker: HR mRNA
Type: Predictive Biomarker (PRD)
Genes: HR
Study 30550515 — Biomarker: RPE mRNA
Type: Predictive Biomarker (PRD)
Genes: RPE; HUSSY-17
Study 25292398 — Biomarker: Thyroid stimulating hormone
Type: Safety Biomarker (SAF)
Study 30779529 — Biomarker: Programmed cell death 1 ligand 1
Type: Predictive Biomarker (PRD)
Genes: CD274; B7H1; PDCD1L1; PDCD1LG1; PDL1
Study 25547983 — Biomarker: C6 mRNA
Type: Predictive Biomarker (PRD)
Genes: C6
Study 20093333 — Biomarker: CD46 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD46; MCP; MIC10
Study 20168306 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 18617314 — Biomarker: TH mRNA
Type: Predictive Biomarker (PRD)
Genes: TH; TYH
Study 18617314 — Biomarker: TF mRNA
Type: Predictive Biomarker (PRD)
Genes: TF; PRO1400
Study 18617314 — Biomarker: HR mRNA
Type: Predictive Biomarker (PRD)
Genes: HR
Study 16143705 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 16143705 — Biomarker: High density lipoprotein cholesterol
Type: Pharmacodynamic Biomarker (PDY)
Study 10574423 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 23150151 — Biomarker: Cytochrome P450 2C19
Type: Safety Biomarker (SAF)
Genes: CYP2C19
Study 23150151 — Biomarker: Multidrug resistance protein 1
Type: Predictive Biomarker (PRD)
Genes: ABCB1; MDR1; PGY1
Study 23150151 — Biomarker: PON1 mRNA
Type: Predictive Biomarker (PRD)
Genes: PON1; PON
Study 16732017 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 15353428 — Biomarker: Bone mineral density
Type: Surrogate Endpoint (SUR)
Study 19369231 — Biomarker: BCR mRNA
Type: Predictive Biomarker (PRD)
Genes: BCR; BCR1; D22S11
Study 19369231 — Biomarker: Tyrosine-protein kinase ABL1
Type: Pharmacodynamic Biomarker (PDY)
Genes: ABL1; ABL; JTK7
Study 9700998 — Biomarker: HR mRNA
Type: Predictive Biomarker (PRD)
Genes: HR
Study 9700998 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 21263198 — Biomarker: POMC
Type: Predictive Biomarker (PRD)
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 12952258 — Biomarker: SERPINA1 mRNA
Type: Predictive Biomarker (PRD)
Genes: SERPINA1; AAT; PI; PRO0684; PRO2209