AIM-Harvard/TrialPanorama-filtered huggingface dataset:
Study 19494809 — Biomarker: UGT2B7 mRNA
Type: Predictive Biomarker (PRD)
Genes: UGT2B7; UGTB2B9
Study 19494809 — Biomarker: ABCC2 mRNA
Type: Predictive Biomarker (PRD)
Genes: ABCC2; CMOAT; CMOAT1; CMRP; MRP2
Study 16461866 — Biomarker: VCP mRNA
Type: Predictive Biomarker (PRD)
Genes: VCP
Study 26796355 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 18581464 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 31717971 — Biomarker: HR mRNA
Type: Predictive Biomarker (PRD)
Genes: HR
Study 29941516 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 16056171 — Biomarker: Bone mineral density
Type: Surrogate Endpoint (SUR)
Study 26728364 — Biomarker: MARS1 mRNA
Type: Predictive Biomarker (PRD)
Genes: MARS1; MARS
Study 20650600 — Biomarker: HR mRNA
Type: Predictive Biomarker (PRD)
Genes: HR
Study 15109191 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 29112591 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 376132 — Biomarker: MERTK mRNA
Type: Predictive Biomarker (PRD)
Genes: MERTK; MER
Study 24089075 — Biomarker: MPG mRNA
Type: Predictive Biomarker (PRD)
Genes: MPG; AAG; ANPG; MID1
Study 19079316 — Biomarker: SCT mRNA
Type: Predictive Biomarker (PRD)
Genes: SCT
Study 11192306 — Biomarker: Interleukin 8
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: CXCL8; IL8
Study 11192306 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 25984808 — Biomarker: DCD mRNA
Type: Predictive Biomarker (PRD)
Genes: DCD; AIDD; DSEP
Study 15361500 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 15361500 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 31687079 — Biomarker: Vitamin B12
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI)
Study 23260750 — Biomarker: PC mRNA
Type: Predictive Biomarker (PRD)
Genes: PC
Study 21785346 — Biomarker: Serum creatinine
Type: Surrogate Endpoint (SUR)
Study 30356126 — Biomarker: L1CAM mRNA
Type: Predictive Biomarker (PRD)
Genes: L1CAM; CAML1; MIC5
Study 30356126 — Biomarker: TP53
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: p53; LFS1
Study 20234364 — Biomarker: Pathological complete response
Type: Surrogate Endpoint (SUR)
Study 11185667 — Biomarker: Vascular endothelial growth factor A
Type: Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: VEGFA; VEGF
Study 2871007 — Biomarker: HR mRNA
Type: Predictive Biomarker (PRD)
Genes: HR
Study 18610754 — Biomarker: Interleukin 2
Type: Safety Biomarker (SAF)
Genes: IL2
Study 12911137 — Biomarker: Serum potassium
Type: Surrogate Endpoint (SUR)
Study 29361433 — Biomarker: CD4 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD4
Study 24723487 — Biomarker: IK mRNA
Type: Predictive Biomarker (PRD)
Genes: IK; RED; RER
Study 21558573 — Biomarker: Free fatty acids
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY)
Study 21558573 — Biomarker: IL-6 and IL-10
Type: Safety Biomarker (SAF)
Study 20470281 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 20470281 — Biomarker: Plasminogen activator inhibitor
Type: Safety Biomarker (SAF)
Genes: SERPINE1; PAI1; PLANH1
Study 12206010 — Biomarker: HR mRNA
Type: Predictive Biomarker (PRD)
Genes: HR
Study 3903734 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 24216257 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 22767646 — Biomarker: Valproic acid
Type: Pharmacodynamic Biomarker (PDY)
Study 16054520 — Biomarker: CD4 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD4
Study 19229978 — Biomarker: PRF1
Type: Predictive Biomarker (PRD)
Genes: PFP; P1; HPLH2
Study 15102867 — Biomarker: Blood coagulation
Type: Pharmacodynamic Biomarker (PDY)
Study 7783654 — Biomarker: LPL mRNA
Type: Predictive Biomarker (PRD)
Genes: LPL; LIPD
Study 2295294 — Biomarker: CCK mRNA
Type: Predictive Biomarker (PRD)
Genes: CCK
Study 12297170 — Biomarker: D-dimer
Type: Safety Biomarker (SAF); Monitoring Biomarker (MOI)
Study 28526870 — Biomarker: miR-133a
Type: Safety Biomarker (SAF)
Study 28526870 — Biomarker: miR-133b
Type: Safety Biomarker (SAF)
Genes: MIR133B
Study 28526870 — Biomarker: miR-206
Type: Safety Biomarker (SAF)
Genes: MIR206
Study 28526870 — Biomarker: miR-181a
Type: Safety Biomarker (SAF)
Study 28526870 — Biomarker: miR-21
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: MIR21
Study 28526870 — Biomarker: Interleukin 10
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: IL10
Study 12110777 — Biomarker: Endothelin-1
Type: Safety Biomarker (SAF); Monitoring Biomarker (MOI)
Genes: EDN1
Study 9449397 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 9449397 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 22947356 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 22947356 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 12135935 — Biomarker: TNF related activation protein
Type: Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CD40LG; CD40L; TNFSF5; TRAP
Study 7072313 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 30567753 — Biomarker: Tyrosine-protein kinase BTK
Type: Pharmacodynamic Biomarker (PDY)
Genes: BTK; AGMX1; ATK; BPK
Study 30567753 — Biomarker: Circulating tumor DNA
Type: Monitoring Biomarker (MOI)
Study 22747705 — Biomarker: MHC class I polypeptide-related sequence A
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: MICA; PERB11.1
Study 17062840 — Biomarker: NUCB2 mRNA
Type: Predictive Biomarker (PRD)
Genes: NUCB2; NEFA
Study 16263089 — Biomarker: TP53INP2 mRNA
Type: Predictive Biomarker (PRD)
Genes: TP53INP2; C20orf110; DOR; PINH
Study 11867377 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 1533186 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 26636096 — Biomarker: PAM mRNA
Type: Predictive Biomarker (PRD)
Genes: PAM
Study 18326962 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 12657225 — Biomarker: DMD mRNA
Type: Predictive Biomarker (PRD)
Genes: DMD
Study 12657225 — Biomarker: DMD
Type: Predictive Biomarker (PRD)
Genes: BMD; DXS142; DXS164; DXS206; DXS230; DXS239; DXS268; DXS269; DXS270; DXS272
Study 12657225 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 12657225 — Biomarker: Interleukin 6
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: IL6; IFNB2
Study 12657225 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 9475305 — Biomarker: Free fatty acids
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY)
Study 2455115 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 18773749 — Biomarker: High density lipoprotein cholesterol
Type: Pharmacodynamic Biomarker (PDY)
Study 18773749 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 8008680 — Biomarker: Free fatty acids
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY)
Study 23814044 — Biomarker: Erbb2 tyrosine kinase receptor
Type: Predictive Biomarker (PRD)
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 19249413 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 15090706 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 8193351 — Biomarker: White blood cell
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Study 2555187 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 27813398 — Biomarker: Bone mineral density
Type: Surrogate Endpoint (SUR)
Study 17481705 — Biomarker: Vascular endothelial growth factor A
Type: Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: VEGFA; VEGF
Study 17481705 — Biomarker: TP53
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: p53; LFS1
Study 17481705 — Biomarker: Vascular endothelial growth factor
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY)
Study 9678787 — Biomarker: Cholesteryl ester transfer protein
Type: Pharmacodynamic Biomarker (PDY)
Genes: CETP
Study 9678787 — Biomarker: Plasminogen activator inhibitor
Type: Safety Biomarker (SAF)
Genes: SERPINE1; PAI1; PLANH1
Study 9678787 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 2566637 — Biomarker: Beta-2-microglobulin
Type: Safety Biomarker (SAF)
Genes: B2M; CDABP0092; HDCMA22P
Study 12875806 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 17703315 — Biomarker: CXCL1 mRNA
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: CXCL1; GRO; GRO1; GROA; MGSA; SCYB1
Study 17703315 — Biomarker: C-X-C motif chemokine 9
Type: Safety Biomarker (SAF); Monitoring Biomarker (MOI)
Genes: CXCL9; CMK; MIG; SCYB9
Study 17703315 — Biomarker: Interleukin 8
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: CXCL8; IL8
Study 7634883 — Biomarker: Forced vital capacity
Type: Surrogate Endpoint (SUR)
Study 7634883 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 21237212 — Biomarker: NPY mRNA
Type: Predictive Biomarker (PRD)
Genes: NPY
Study 21237212 — Biomarker: Free fatty acids
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY)
Study 15784036 — Biomarker: HR mRNA
Type: Predictive Biomarker (PRD)
Genes: HR
Study 1779513 — Biomarker: MBP mRNA
Type: Predictive Biomarker (PRD)
Genes: MBP
Study 1779513 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 21793389 — Biomarker: SP6 mRNA
Type: Predictive Biomarker (PRD)
Genes: SP6; KLF14
Study 8033496 — Biomarker: ACAT1 mRNA
Type: Predictive Biomarker (PRD)
Genes: ACAT1; ACAT; MAT
Study 8033496 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 28011037 — Biomarker: CFTR mRNA
Type: Predictive Biomarker (PRD)
Genes: CFTR; ABCC7
Study 12753318 — Biomarker: Bone mineral density
Type: Surrogate Endpoint (SUR)
Study 10618584 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 11565519 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 3034018 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 3034018 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 10233186 — Biomarker: Endothelin-1
Type: Safety Biomarker (SAF); Monitoring Biomarker (MOI)
Genes: EDN1
Study 29555790 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 19663893 — Biomarker: Interleukin 2 receptor alpha
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: IL2RA
Study 14574348 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 14574348 — Biomarker: High density lipoprotein cholesterol
Type: Pharmacodynamic Biomarker (PDY)
Study 14574348 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 22685122 — Biomarker: SCT mRNA
Type: Predictive Biomarker (PRD)
Genes: SCT
Study 16135900 — Biomarker: CD4 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD4
Study 31272931 — Biomarker: PCSK9 mRNA
Type: Predictive Biomarker (PRD)
Genes: PCSK9; NARC1; PSEC0052
Study 28097266 — Biomarker: MCC mRNA
Type: Predictive Biomarker (PRD)
Genes: MCC
Study 25340318 — Biomarker: CD4 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD4
Study 16946093 — Biomarker: CD14 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD14
Study 16946093 — Biomarker: TLR4 mRNA
Type: Predictive Biomarker (PRD)
Genes: TLR4
Study 16946093 — Biomarker: LY96
Type: Predictive Biomarker (PRD)
Genes: MD-2
Study 27121444 — Biomarker: ACE2 mRNA
Type: Predictive Biomarker (PRD)
Genes: ACE2; UNQ868/PRO1885
Study 27121444 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 27121444 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 20235838 — Biomarker: CD4 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD4
Study 31986357 — Biomarker: Vascular endothelial growth factor A
Type: Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: VEGFA; VEGF
Study 31986357 — Biomarker: Vascular endothelial growth factor
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY)
Study 26150412 — Biomarker: SCAMP1 mRNA
Type: Predictive Biomarker (PRD)
Genes: SCAMP1; SCAMP
Study 19651163 — Biomarker: PYY mRNA
Type: Predictive Biomarker (PRD)
Genes: PYY
Study 22054688 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 16230866 — Biomarker: B-type natriuretic peptide
Type: Safety Biomarker (SAF)
Genes: NPPB
Study 10228112 — Biomarker: CFTR mRNA
Type: Predictive Biomarker (PRD)
Genes: CFTR; ABCC7
Study 10228112 — Biomarker: TNFRSF10A mRNA
Type: Predictive Biomarker (PRD)
Genes: TNFRSF10A; APO2; DR4; TRAILR1
Study 20197785 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 2222979 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 26688235 — Biomarker: Granulocyte-macrophage colony-stimulating factor
Type: Safety Biomarker (SAF)
Genes: CSF2; GMCSF
Study 23421759 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 23421759 — Biomarker: Serum triglycerides
Type: Surrogate Endpoint (SUR)
Study 23421759 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 21915478 — Biomarker: Thyroid stimulating hormone
Type: Safety Biomarker (SAF)
Study 19506099 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 19506099 — Biomarker: Endothelin-1
Type: Safety Biomarker (SAF); Monitoring Biomarker (MOI)
Genes: EDN1
Study 16834970 — Biomarker: TG mRNA
Type: Predictive Biomarker (PRD)
Genes: TG
Study 16834970 — Biomarker: Thyroid stimulating hormone
Type: Safety Biomarker (SAF)
Study 10445673 — Biomarker: Pulmonary vascular resistance
Type: Surrogate Endpoint (SUR)
Study 15848575 — Biomarker: C2 mRNA
Type: Predictive Biomarker (PRD)
Genes: C2
Study 11882931 — Biomarker: EPX mRNA
Type: Predictive Biomarker (PRD)
Genes: EPX; EPER; EPO; EPP
Study 10531077 — Biomarker: Bone mineral density
Type: Surrogate Endpoint (SUR)
Study 7789045 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 7789045 — Biomarker: Serum potassium
Type: Surrogate Endpoint (SUR)
Study 30327952 — Biomarker: Ornithine transcarbamylase
Type: Safety Biomarker (SAF)
Genes: OTC
Study 29211893 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 26918556 — Biomarker: Gastric inhibitory polypeptide
Type: Pharmacodynamic Biomarker (PDY)
Genes: GIP
Study 7549411 — Biomarker: HR mRNA
Type: Predictive Biomarker (PRD)
Genes: HR
Study 7549411 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 31020351 — Biomarker: ALK tyrosine kinase receptor
Type: Predictive Biomarker (PRD)
Genes: ALK
Study 22641777 — Biomarker: HR mRNA
Type: Predictive Biomarker (PRD)
Genes: HR
Study 10490438 — Biomarker: GNRH1 mRNA
Type: Predictive Biomarker (PRD)
Genes: GNRH1; GNRH; GRH; LHRH
Study 16817038 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 12614804 — Biomarker: Cardiac troponin I
Type: Safety Biomarker (SAF)
Genes: TNNI3; TNNC1
Study 28453453 — Biomarker: Bone mineral density
Type: Surrogate Endpoint (SUR)
Study 24905629 — Biomarker: UCP3 mRNA
Type: Predictive Biomarker (PRD)
Genes: UCP3; SLC25A9
Study 24905629 — Biomarker: Free fatty acids
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY)
Study 22301417 — Biomarker: CD4 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD4
Study 19952998 — Biomarker: RPE mRNA
Type: Predictive Biomarker (PRD)
Genes: RPE; HUSSY-17
Study 12218740 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 12218740 — Biomarker: High density lipoprotein cholesterol
Type: Pharmacodynamic Biomarker (PDY)
Study 21378155 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 21378155 — Biomarker: von Willebrand factor
Type: Safety Biomarker (SAF)
Genes: VWF; F8VWF
Study 21378155 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 21378155 — Biomarker: Interleukin 6
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: IL6; IFNB2
Study 29453687 — Biomarker: Cytochrome P450 2C19
Type: Safety Biomarker (SAF)
Genes: CYP2C19
Study 29453687 — Biomarker: CYP2B6 mRNA
Type: Predictive Biomarker (PRD)
Genes: CYP2B6
Study 18268065 — Biomarker: NLRP1 mRNA
Type: Predictive Biomarker (PRD)
Genes: NLRP1; CARD7; DEFCAP; KIAA0926; NAC; NALP1
Study 18268065 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 18268065 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 18268065 — Biomarker: Plasminogen activator inhibitor
Type: Safety Biomarker (SAF)
Genes: SERPINE1; PAI1; PLANH1
Study 12460699 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 12460699 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 10554808 — Biomarker: TPO mRNA
Type: Predictive Biomarker (PRD)
Genes: TPO
Study 10554808 — Biomarker: Granulocyte-macrophage colony-stimulating factor
Type: Safety Biomarker (SAF)
Genes: CSF2; GMCSF
Study 10554808 — Biomarker: EPX mRNA
Type: Predictive Biomarker (PRD)
Genes: EPX; EPER; EPO; EPP
Study 31780869 — Biomarker: Myeloperoxidase
Type: Safety Biomarker (SAF)
Genes: MPO
Study 31780869 — Biomarker: Metalloproteinase inhibitor 1
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: TIMP1; CLGI; TIMP
Study 25083802 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 12239432 — Biomarker: Reactive oxygen species
Type: Safety Biomarker (SAF)
Study 31204078 — Biomarker: Programmed cell death 1 ligand 1
Type: Predictive Biomarker (PRD)
Genes: CD274; B7H1; PDCD1L1; PDCD1LG1; PDL1
Study 31204078 — Biomarker: Microsatellite instability
Type: Predictive Biomarker (PRD)
Study 31204078 — Biomarker: Tumor mutational burden
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Study 19789415 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 19789415 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 17257820 — Biomarker: FEV mRNA
Type: Predictive Biomarker (PRD)
Genes: FEV; PET1
Study 11744606 — Biomarker: PAH mRNA
Type: Predictive Biomarker (PRD)
Genes: PAH
Study 7990700 — Biomarker: Free fatty acids
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY)
Study 28679486 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 28679486 — Biomarker: von Willebrand factor
Type: Safety Biomarker (SAF)
Genes: VWF; F8VWF
Study 28679486 — Biomarker: Plasminogen activator inhibitor
Type: Safety Biomarker (SAF)
Genes: SERPINE1; PAI1; PLANH1
Study 25727857 — Biomarker: SERPINA1 mRNA
Type: Predictive Biomarker (PRD)
Genes: SERPINA1; AAT; PI; PRO0684; PRO2209
Study 19484786 — Biomarker: Bone mineral density
Type: Surrogate Endpoint (SUR)
Study 10410299 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 31533751 — Biomarker: Vascular endothelial growth factor A
Type: Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: VEGFA; VEGF
Study 31533751 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 31533751 — Biomarker: Vascular endothelial growth factor
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY)
Study 19753300 — Biomarker: CD4 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD4
Study 17319412 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 8006914 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 8006914 — Biomarker: Serum potassium
Type: Surrogate Endpoint (SUR)
Study 19516176 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 3207855 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 15752879 — Biomarker: NPEPPS mRNA
Type: Predictive Biomarker (PRD)
Genes: NPEPPS; PSA
Study 11930309 — Biomarker: Neutralizing antibody
Type: Surrogate Endpoint (SUR)
Study 11930309 — Biomarker: Preexisting antibody
Type: Safety Biomarker (SAF)
Study 31579987 — Biomarker: Hyaluronic acid
Type: Safety Biomarker (SAF)
Study 29314176 — Biomarker: TP53
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: p53; LFS1
Study 19737527 — Biomarker: CD4 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD4
Study 8829023 — Biomarker: High density lipoprotein cholesterol
Type: Pharmacodynamic Biomarker (PDY)
Study 21600325 — Biomarker: TNFRSF11B mRNA
Type: Predictive Biomarker (PRD)
Genes: TNFRSF11B; OCIF; OPG
Study 21600325 — Biomarker: Vascular endothelial growth factor A
Type: Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: VEGFA; VEGF
Study 29911909 — Biomarker: IMPA1 mRNA
Type: Predictive Biomarker (PRD)
Genes: IMPA1; IMPA
Study 19682803 — Biomarker: BDNF mRNA
Type: Predictive Biomarker (PRD); Monitoring Biomarker (MOI)
Genes: BDNF
Study 19682803 — Biomarker: BDNF
Type: Safety Biomarker (SAF)
Study 9376574 — Biomarker: KITLG mRNA
Type: Predictive Biomarker (PRD)
Genes: KITLG; MGF; SCF
Study 9376574 — Biomarker: CD34 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD34
Study 11886505 — Biomarker: TP53
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: p53; LFS1
Study 24607773 — Biomarker: EDNRA mRNA
Type: Predictive Biomarker (PRD)
Genes: EDNRA; ETA; ETRA
Study 24607773 — Biomarker: Endothelin-1
Type: Safety Biomarker (SAF); Monitoring Biomarker (MOI)
Genes: EDN1
Study 17299116 — Biomarker: HP mRNA
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: HP
Study 17299116 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 17472017 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 2836565 — Biomarker: CP mRNA
Type: Predictive Biomarker (PRD)
Genes: CP
Study 18053632 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 12830671 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 17418038 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 15229622 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 15229622 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 15229622 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 10431997 — Biomarker: Matrix metalloproteinase 1
Type: Monitoring Biomarker (MOI)
Genes: MMP1; CLG
Study 10431997 — Biomarker: Interleukin 6
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: IL6; IFNB2
Study 10431997 — Biomarker: MMP-1
Type: Safety Biomarker (SAF)
Genes: MMP1
Study 6499724 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 29949174 — Biomarker: HR mRNA
Type: Predictive Biomarker (PRD)
Genes: HR
Study 29949174 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 15202583 — Biomarker: Bone mineral density
Type: Surrogate Endpoint (SUR)
Study 15202583 — Biomarker: Estrogen receptor
Type: Predictive Biomarker (PRD)
Genes: ESR1; ESR; NR3A1