AIM-Harvard/TrialPanorama-filtered huggingface dataset:
Study 15110130 — Biomarker: High density lipoprotein cholesterol
Type: Pharmacodynamic Biomarker (PDY)
Study 11260540 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 11260540 — Biomarker: Serum creatinine
Type: Surrogate Endpoint (SUR)
Study 19013293 — Biomarker: Thyroid stimulating hormone
Type: Safety Biomarker (SAF)
Study 12618690 — Biomarker: Arginine vasopressin
Type: Predictive Biomarker (PRD)
Genes: AVP; ARVP; VP
Study 10587038 — Biomarker: HPR mRNA
Type: Predictive Biomarker (PRD)
Genes: HPR
Study 22441345 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 9849704 — Biomarker: PC mRNA
Type: Predictive Biomarker (PRD)
Genes: PC
Study 9849704 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 2570283 — Biomarker: Granulocyte-macrophage colony-stimulating factor
Type: Safety Biomarker (SAF)
Genes: CSF2; GMCSF
Study 27833860 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 23228097 — Biomarker: Serum creatinine
Type: Surrogate Endpoint (SUR)
Study 30907141 — Biomarker: TTR mRNA
Type: Predictive Biomarker (PRD)
Genes: TTR; PALB
Study 16981140 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 16981140 — Biomarker: High density lipoprotein cholesterol
Type: Pharmacodynamic Biomarker (PDY)
Study 15287931 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 15287931 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 8215644 — Biomarker: D-dimer
Type: Safety Biomarker (SAF); Monitoring Biomarker (MOI)
Study 24748301 — Biomarker: FSTL1 mRNA
Type: Predictive Biomarker (PRD)
Genes: FSTL1; FRP
Study 8985227 — Biomarker: IL-6 and IL-10
Type: Safety Biomarker (SAF)
Study 24299914 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 9252849 — Biomarker: Biliary glycoprotein 1
Type: Safety Biomarker (SAF)
Genes: CEACAM1; BGP; BGP1
Study 9252849 — Biomarker: Bone mineral density
Type: Surrogate Endpoint (SUR)
Study 21700892 — Biomarker: AHR mRNA
Type: Predictive Biomarker (PRD)
Genes: AHR; BHLHE76
Study 17509587 — Biomarker: Serum luteinizing hormone
Type: Surrogate Endpoint (SUR)
Study 29216361 — Biomarker: Hormone receptor
Type: Predictive Biomarker (PRD)
Study 18301060 — Biomarker: CD4 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD4
Study 16463698 — Biomarker: Superoxide dismutase Cu-Zn
Type: Pharmacodynamic Biomarker (PDY)
Genes: SOD1
Study 16463698 — Biomarker: Lactate dehydrogenase
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Study 12185552 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 29017796 — Biomarker: CCL17 mRNA
Type: Predictive Biomarker (PRD)
Genes: CCL17; SCYA17; TARC
Study 29017796 — Biomarker: TSLP mRNA
Type: Predictive Biomarker (PRD)
Genes: TSLP
Study 29017796 — Biomarker: STAT1 mRNA
Type: Predictive Biomarker (PRD)
Genes: STAT1
Study 29017796 — Biomarker: Lactate dehydrogenase
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Study 15226327 — Biomarker: Granulocyte-macrophage colony-stimulating factor
Type: Safety Biomarker (SAF)
Genes: CSF2; GMCSF
Study 16550734 — Biomarker: Cytochrome P450 2C19
Type: Safety Biomarker (SAF)
Genes: CYP2C19
Study 17588581 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 17588581 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 17588581 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 8676836 — Biomarker: DMA mRNA
Type: Predictive Biomarker (PRD)
Genes: DMA; HLA-DMA; hCG_2001572
Study 8676836 — Biomarker: Serum albumin
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY)
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 1335008 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 24657333 — Biomarker: Serum calcium
Type: Surrogate Endpoint (SUR)
Study 9389427 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 17711378 — Biomarker: CD4 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD4
Study 12195238 — Biomarker: Interleukin 2
Type: Safety Biomarker (SAF)
Genes: IL2
Study 23958526 — Biomarker: Vascular endothelial growth factor A
Type: Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: VEGFA; VEGF
Study 23958526 — Biomarker: Vascular endothelial growth factor
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY)
Study 15201620 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 28715944 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 23013513 — Biomarker: Interleukin 6
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: IL6; IFNB2
Study 23013513 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 16402128 — Biomarker: CYP2A6 mRNA
Type: Predictive Biomarker (PRD)
Genes: CYP2A6; CYP2A3
Study 11075741 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 11075741 — Biomarker: High density lipoprotein cholesterol
Type: Pharmacodynamic Biomarker (PDY)
Study 16722841 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 27496336 — Biomarker: Serum calcium
Type: Surrogate Endpoint (SUR)
Study 27496336 — Biomarker: Intact parathyroid hormone
Type: Predictive Biomarker (PRD)
Study 25488826 — Biomarker: CYP24A1 mRNA
Type: Predictive Biomarker (PRD)
Genes: CYP24A1; CYP24
Study 25488826 — Biomarker: CYP27B1 mRNA
Type: Predictive Biomarker (PRD)
Genes: CYP27B1; CYP1ALPHA; CYP27B
Study 25488826 — Biomarker: Vitamin D-binding protein
Type: Predictive Biomarker (PRD)
Genes: GC
Study 2890669 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 30103679 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 11834535 — Biomarker: High density lipoprotein cholesterol
Type: Pharmacodynamic Biomarker (PDY)
Study 24898552 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 19170164 — Biomarker: CD34 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD34
Study 3153710 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 31822251 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 18226399 — Biomarker: DDAH1 mRNA
Type: Predictive Biomarker (PRD)
Genes: DDAH1; DDAH
Study 31533906 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 31533906 — Biomarker: Serum potassium
Type: Surrogate Endpoint (SUR)
Study 7752866 — Biomarker: Reactive oxygen species
Type: Safety Biomarker (SAF)
Study 31683132 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 16838645 — Biomarker: Interleukin 2
Type: Safety Biomarker (SAF)
Genes: IL2
Study 9269644 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 9269644 — Biomarker: Beta-2-microglobulin
Type: Safety Biomarker (SAF)
Genes: B2M; CDABP0092; HDCMA22P
Study 6125171 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 6125171 — Biomarker: Free fatty acids
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY)
Study 30014863 — Biomarker: TF mRNA
Type: Predictive Biomarker (PRD)
Genes: TF; PRO1400
Study 25199060 — Biomarker: Interleukin 5
Type: Predictive Biomarker (PRD)
Genes: IL5
Study 3396298 — Biomarker: Serum phosphate
Type: Pharmacodynamic Biomarker (PDY)
Study 31495881 — Biomarker: Serum creatinine
Type: Surrogate Endpoint (SUR)
Study 24355439 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 24355439 — Biomarker: Interleukin 6
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: IL6; IFNB2
Study 24355439 — Biomarker: Interleukin 12
Type: Safety Biomarker (SAF)
Study 24355439 — Biomarker: Interleukin 1
Type: Safety Biomarker (SAF)
Study 24355439 — Biomarker: Interleukin 10
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: IL10
Study 18337713 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 12846338 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 8689812 — Biomarker: CYP3A4 mRNA
Type: Predictive Biomarker (PRD)
Genes: CYP3A4; CYP3A3
Study 30648627 — Biomarker: Bone mineral density
Type: Surrogate Endpoint (SUR)
Study 15084372 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 15894835 — Biomarker: Cyclic guanosine monophosphate
Type: Pharmacodynamic Biomarker (PDY)
Study 15894835 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 11747848 — Biomarker: Serum creatinine
Type: Surrogate Endpoint (SUR)
Study 8405011 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 30405211 — Biomarker: CDA mRNA
Type: Predictive Biomarker (PRD)
Genes: CDA; CDD
Study 30405211 — Biomarker: CDA
Type: Safety Biomarker (SAF)
Genes: CDD
Study 20031461 — Biomarker: RPLP0 mRNA
Type: Predictive Biomarker (PRD)
Genes: RPLP0
Study 27373900 — Biomarker: Cervical intraepithelial neoplasia
Type: Surrogate Endpoint (SUR)
Study 19453623 — Biomarker: POMC
Type: Predictive Biomarker (PRD)
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 30041682 — Biomarker: HR mRNA
Type: Predictive Biomarker (PRD)
Genes: HR
Study 23769603 — Biomarker: C2 mRNA
Type: Predictive Biomarker (PRD)
Genes: C2
Study 20492042 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 21411615 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 16617567 — Biomarker: Vascular endothelial growth factor A
Type: Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: VEGFA; VEGF
Study 16617567 — Biomarker: Hormone receptor
Type: Predictive Biomarker (PRD)
Study 28448457 — Biomarker: Bone mineral density
Type: Surrogate Endpoint (SUR)
Study 24125113 — Biomarker: PDE5A mRNA
Type: Predictive Biomarker (PRD)
Genes: PDE5A; PDE5
Study 10519494 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 31399091 — Biomarker: Matrix metalloproteinase 9
Type: Pharmacodynamic Biomarker (PDY)
Genes: MMP9; CLG4B
Study 31399091 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 23782920 — Biomarker: TLR4 mRNA
Type: Predictive Biomarker (PRD)
Genes: TLR4
Study 23782920 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 18588512 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 18588512 — Biomarker: Extracellular signal-regulated kinase
Type: Pharmacodynamic Biomarker (PDY)
Study 11729708 — Biomarker: Serum sodium
Type: Surrogate Endpoint (SUR)
Study 2887189 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 30406067 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 16619561 — Biomarker: Epidermal growth factor receptor
Type: Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: EGFR; ERBB; ERBB1; HER1
Study 16619561 — Biomarker: Estrogen receptor
Type: Predictive Biomarker (PRD)
Genes: ESR1; ESR; NR3A1
Study 618711 — Biomarker: Serum albumin
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY)
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 618711 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 16296399 — Biomarker: PC mRNA
Type: Predictive Biomarker (PRD)
Genes: PC
Study 15845796 — Biomarker: MIP mRNA
Type: Predictive Biomarker (PRD)
Genes: MIP; AQP0
Study 10596916 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 10596916 — Biomarker: Interferon gamma
Type: Safety Biomarker (SAF); Monitoring Biomarker (MOI)
Genes: IFNG
Study 28122382 — Biomarker: DPT mRNA
Type: Predictive Biomarker (PRD)
Genes: DPT
Study 21111590 — Biomarker: FEV mRNA
Type: Predictive Biomarker (PRD)
Genes: FEV; PET1
Study 19379147 — Biomarker: Serum albumin
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY)
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 9497572 — Biomarker: TP53
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: p53; LFS1
Study 31541565 — Biomarker: AGA mRNA
Type: Predictive Biomarker (PRD)
Genes: AGA
Study 20399996 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 18061070 — Biomarker: Reactive oxygen species
Type: Safety Biomarker (SAF)
Study 27394187 — Biomarker: Granulocyte-macrophage colony-stimulating factor
Type: Safety Biomarker (SAF)
Genes: CSF2; GMCSF
Study 2122630 — Biomarker: Free fatty acids
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY)
Study 29902418 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 24341324 — Biomarker: HR mRNA
Type: Predictive Biomarker (PRD)
Genes: HR
Study 23312888 — Biomarker: Erbb2 tyrosine kinase receptor
Type: Predictive Biomarker (PRD)
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 23312888 — Biomarker: Hormone receptor
Type: Predictive Biomarker (PRD)
Study 15722700 — Biomarker: Adenosine deaminase
Type: Monitoring Biomarker (MOI)
Genes: ADA; ADA1
Study 28488924 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 22860302 — Biomarker: HR mRNA
Type: Predictive Biomarker (PRD)
Genes: HR
Study 22860302 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 18467544 — Biomarker: Bone mineral density
Type: Surrogate Endpoint (SUR)
Study 6861446 — Biomarker: Serum potassium
Type: Surrogate Endpoint (SUR)
Study 30796027 — Biomarker: CD14 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD14
Study 22647753 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 22647753 — Biomarker: High density lipoprotein cholesterol
Type: Pharmacodynamic Biomarker (PDY)
Study 17385022 — Biomarker: MPL mRNA
Type: Predictive Biomarker (PRD)
Genes: MPL; TPOR
Study 10215706 — Biomarker: Serum albumin
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY)
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 8977914 — Biomarker: MB mRNA
Type: Predictive Biomarker (PRD)
Genes: MB
Study 29517132 — Biomarker: Arachidonate 5-lipoxygenase activating protein
Type: Safety Biomarker (SAF)
Genes: ALOX5AP; FLAP
Study 24059649 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 24059649 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 24059649 — Biomarker: Interleukin 10
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: IL10
Study 28724652 — Biomarker: AHR mRNA
Type: Predictive Biomarker (PRD)
Genes: AHR; BHLHE76
Study 21078200 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 14550442 — Biomarker: NPEPPS mRNA
Type: Predictive Biomarker (PRD)
Genes: NPEPPS; PSA
Study 23651425 — Biomarker: Serum testosterone
Type: Surrogate Endpoint (SUR)
Study 18979716 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 18979716 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 10764418 — Biomarker: Nerve growth factor
Type: Predictive Biomarker (PRD)
Genes: NGF; NGFB
Study 1611639 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 24185044 — Biomarker: CCR5 mRNA
Type: Predictive Biomarker (PRD)
Genes: CCR5; CMKBR5
Study 24185044 — Biomarker: CD4 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD4
Study 17504798 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 16248466 — Biomarker: FST mRNA
Type: Predictive Biomarker (PRD)
Genes: FST
Study 369991 — Biomarker: TF mRNA
Type: Predictive Biomarker (PRD)
Genes: TF; PRO1400
Study 31215037 — Biomarker: CD4 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD4
Study 30920602 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 30920602 — Biomarker: High density lipoprotein cholesterol
Type: Pharmacodynamic Biomarker (PDY)
Study 30920602 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 17204591 — Biomarker: TPR mRNA
Type: Predictive Biomarker (PRD)
Genes: TPR
Study 17204591 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 21722959 — Biomarker: KCNN3 mRNA
Type: Predictive Biomarker (PRD)
Genes: KCNN3; K3
Study 19155978 — Biomarker: SRL mRNA
Type: Predictive Biomarker (PRD)
Genes: SRL
Study 16467647 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 8986684 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 28737273 — Biomarker: CFH mRNA
Type: Predictive Biomarker (PRD)
Genes: CFH; HF; HF1; HF2
Study 16087057 — Biomarker: POMC
Type: Predictive Biomarker (PRD)
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 3929067 — Biomarker: Adrenomedullin
Type: Safety Biomarker (SAF); Monitoring Biomarker (MOI)
Genes: ADM; AM
Study 29450689 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 26699690 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 26699690 — Biomarker: Interleukin 6
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: IL6; IFNB2
Study 15885641 — Biomarker: T-lymphocyte activation antigen CD86
Type: Pharmacodynamic Biomarker (PDY)
Genes: CD86; CD28LG2
Study 10378632 — Biomarker: Granulocyte-macrophage colony-stimulating factor
Type: Safety Biomarker (SAF)
Genes: CSF2; GMCSF
Study 27342507 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 22248153 — Biomarker: PDE5A mRNA
Type: Predictive Biomarker (PRD)
Genes: PDE5A; PDE5
Study 10800818 — Biomarker: ITGB2 mRNA
Type: Predictive Biomarker (PRD)
Genes: ITGB2; CD18; MFI7
Study 22473769 — Biomarker: Microtubule-associated protein tau
Type: Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY)
Genes: MAPT; MAPTL; MTBT1; TAU
Study 12527599 — Biomarker: FEV mRNA
Type: Predictive Biomarker (PRD)
Genes: FEV; PET1
Study 30725040 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 26891420 — Biomarker: KRAS mRNA
Type: Predictive Biomarker (PRD)
Genes: KRAS; KRAS2; RASK2
Study 26891420 — Biomarker: Proto-oncogene c-Met
Type: Predictive Biomarker (PRD)
Genes: MET
Study 26891420 — Biomarker: Epidermal growth factor receptor
Type: Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: EGFR; ERBB; ERBB1; HER1
Study 26891420 — Biomarker: Phosphatase and tensin homolog
Type: Predictive Biomarker (PRD)
Genes: PTEN; MMAC1; TEP1
Study 18794027 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 6142700 — Biomarker: Immunoglobulin E
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Study 31166681 — Biomarker: Apoptosis regulator Bcl-2
Type: Predictive Biomarker (PRD)
Genes: BCL2
Study 31166681 — Biomarker: Cellular tumor antigen p53
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: TP53; P53
Study 23507474 — Biomarker: Thyroid stimulating hormone
Type: Safety Biomarker (SAF)
Study 20732932 — Biomarker: HR mRNA
Type: Predictive Biomarker (PRD)
Genes: HR
Study 20732932 — Biomarker: Hormone receptor
Type: Predictive Biomarker (PRD)
Study 12682802 — Biomarker: CYP3A4 mRNA
Type: Predictive Biomarker (PRD)
Genes: CYP3A4; CYP3A3
Study 18430173 — Biomarker: Hyaluronic acid
Type: Safety Biomarker (SAF)
Study 12552211 — Biomarker: Pulmonary vascular resistance
Type: Surrogate Endpoint (SUR)
Study 10532441 — Biomarker: AMD1 mRNA
Type: Predictive Biomarker (PRD)
Genes: AMD1; AMD
Study 26474055 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 26474055 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 8231773 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 25009220 — Biomarker: HSPA5 mRNA
Type: Predictive Biomarker (PRD)
Genes: HSPA5; GRP78
Study 25009220 — Biomarker: EIF2AK3 mRNA
Type: Predictive Biomarker (PRD)
Genes: EIF2AK3; PEK; PERK
Study 25009220 — Biomarker: ATF6 mRNA
Type: Predictive Biomarker (PRD)
Genes: ATF6
Study 25009220 — Biomarker: ATF4 mRNA
Type: Predictive Biomarker (PRD)
Genes: ATF4; CREB2; TXREB
Study 25009220 — Biomarker: DDIT3 mRNA
Type: Predictive Biomarker (PRD)
Genes: DDIT3; CHOP; CHOP10; GADD153
Study 15608524 — Biomarker: Mitochondrial DNA
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY)
Study 2401128 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 19568199 — Biomarker: HR mRNA
Type: Predictive Biomarker (PRD)
Genes: HR
Study 19568199 — Biomarker: Free fatty acids
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY)
Study 17584560 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 11160540 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 7853324 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 30342298 — Biomarker: TG mRNA
Type: Predictive Biomarker (PRD)
Genes: TG
Study 30342298 — Biomarker: Peroxisome proliferator-activated receptor alpha
Type: Safety Biomarker (SAF)
Genes: PPARA
Study 30342298 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 30342298 — Biomarker: High density lipoprotein cholesterol
Type: Pharmacodynamic Biomarker (PDY)
Study 23978276 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 2065534 — Biomarker: MAS1 mRNA
Type: Predictive Biomarker (PRD)
Genes: MAS1; MAS
Study 3909842 — Biomarker: Serum albumin
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY)
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 3909842 — Biomarker: Antithrombin-III
Type: Safety Biomarker (SAF)
Genes: SERPINC1; AT3; PRO0309
Study 9003465 — Biomarker: Aminopeptidase N
Type: Safety Biomarker (SAF)
Genes: ANPEP; APN; CD13; PEPN
Study 9003465 — Biomarker: CD14 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD14
Study 9003465 — Biomarker: FCGR3B
Type: Predictive Biomarker (PRD)
Genes: CD16; CD16b; FcgammaRIIIb; FcRIIIb
Study 22962863 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 22744704 — Biomarker: TES mRNA
Type: Predictive Biomarker (PRD)
Genes: TES
Study 29604186 — Biomarker: CXCL13 mRNA
Type: Predictive Biomarker (PRD)
Genes: CXCL13; BCA1; BLC; SCYB13
Study 27709863 — Biomarker: Hyaluronic acid
Type: Safety Biomarker (SAF)
Study 28690011 — Biomarker: Vascular endothelial growth factor A
Type: Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: VEGFA; VEGF
Study 28690011 — Biomarker: Vascular endothelial growth factor
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY)
Study 12958322 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 29268948 — Biomarker: Programmed cell death 1 ligand 1
Type: Predictive Biomarker (PRD)
Genes: CD274; B7H1; PDCD1L1; PDCD1LG1; PDL1
Study 26788432 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 12834935 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 20860572 — Biomarker: EP300 mRNA
Type: Predictive Biomarker (PRD)
Genes: EP300; P300