AIM-Harvard/TrialPanorama-filtered huggingface dataset:
Study 9263161 — Biomarker: ACR mRNA
Type: Predictive Biomarker (PRD)
Genes: ACR; ACRS
Study 29268886 — Biomarker: VASP mRNA
Type: Predictive Biomarker (PRD)
Genes: VASP
Study 25844616 — Biomarker: Epidermal growth factor
Type: Monitoring Biomarker (MOI)
Genes: EGF
Study 21813548 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 3010516 — Biomarker: ARC mRNA
Type: Predictive Biomarker (PRD)
Genes: ARC; KIAA0278
Study 19834313 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 7760868 — Biomarker: Granulocyte-macrophage colony-stimulating factor
Type: Safety Biomarker (SAF)
Genes: CSF2; GMCSF
Study 6140939 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 6140939 — Biomarker: Forced vital capacity
Type: Surrogate Endpoint (SUR)
Study 24335026 — Biomarker: MB mRNA
Type: Predictive Biomarker (PRD)
Genes: MB
Study 17395756 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 11433224 — Biomarker: Serum sodium
Type: Surrogate Endpoint (SUR)
Study 8179848 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 16150800 — Biomarker: HR mRNA
Type: Predictive Biomarker (PRD)
Genes: HR
Study 16150800 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 10814909 — Biomarker: LAD1 mRNA
Type: Predictive Biomarker (PRD)
Genes: LAD1; LAD
Study 8690829 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 1626680 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 31161374 — Biomarker: AFP mRNA
Type: Predictive Biomarker (PRD)
Genes: AFP; HPAFP
Study 24495481 — Biomarker: Cellular tumor antigen p53
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: TP53; P53
Study 24495481 — Biomarker: TP53
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: p53; LFS1
Study 2151874 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 9119980 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 9119980 — Biomarker: CD2 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD2; SRBC
Study 9119980 — Biomarker: CD4 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD4
Study 27779460 — Biomarker: Serum creatinine
Type: Surrogate Endpoint (SUR)
Study 27779460 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 7546753 — Biomarker: HR mRNA
Type: Predictive Biomarker (PRD)
Genes: HR
Study 2265259 — Biomarker: Hormone receptor
Type: Predictive Biomarker (PRD)
Study 2265259 — Biomarker: Estrogen receptor
Type: Predictive Biomarker (PRD)
Genes: ESR1; ESR; NR3A1
Study 7417366 — Biomarker: Blood coagulation
Type: Pharmacodynamic Biomarker (PDY)
Study 31426760 — Biomarker: Cell-free DNA
Type: Monitoring Biomarker (MOI)
Study 21378213 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 19627261 — Biomarker: CP mRNA
Type: Predictive Biomarker (PRD)
Genes: CP
Study 19627261 — Biomarker: REM1 mRNA
Type: Predictive Biomarker (PRD)
Genes: REM1; GES; REM
Study 11698604 — Biomarker: ASL mRNA
Type: Predictive Biomarker (PRD)
Genes: ASL
Study 11698604 — Biomarker: MCAT mRNA
Type: Predictive Biomarker (PRD)
Genes: MCAT; MT
Study 11698604 — Biomarker: MAP3K10 mRNA
Type: Predictive Biomarker (PRD)
Genes: MAP3K10; MLK2; MST
Study 29899643 — Biomarker: AMD1 mRNA
Type: Predictive Biomarker (PRD)
Genes: AMD1; AMD
Study 25422235 — Biomarker: Serum albumin
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY)
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 25422235 — Biomarker: TTR mRNA
Type: Predictive Biomarker (PRD)
Genes: TTR; PALB
Study 27530339 — Biomarker: CD34 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD34
Study 27530339 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 21570643 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 16484769 — Biomarker: Forced vital capacity
Type: Surrogate Endpoint (SUR)
Study 10697374 — Biomarker: Superoxide dismutase Cu-Zn
Type: Pharmacodynamic Biomarker (PDY)
Genes: SOD1
Study 31291793 — Biomarker: Reactive oxygen species
Type: Safety Biomarker (SAF)
Study 12584787 — Biomarker: LPO mRNA
Type: Predictive Biomarker (PRD)
Genes: LPO; SAPX
Study 12584787 — Biomarker: Superoxide dismutase Cu-Zn
Type: Pharmacodynamic Biomarker (PDY)
Genes: SOD1
Study 4014126 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 20842168 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 29512972 — Biomarker: AGA mRNA
Type: Predictive Biomarker (PRD)
Genes: AGA
Study 19940079 — Biomarker: Pulmonary vascular resistance
Type: Surrogate Endpoint (SUR)
Study 12145221 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 7824108 — Biomarker: Plasma ammonia
Type: Surrogate Endpoint (SUR)
Study 204949 — Biomarker: REM1 mRNA
Type: Predictive Biomarker (PRD)
Genes: REM1; GES; REM
Study 23822689 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 11046100 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 11046100 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 9381993 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 9381993 — Biomarker: High density lipoprotein cholesterol
Type: Pharmacodynamic Biomarker (PDY)
Study 9381993 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 7780255 — Biomarker: Bone mineral density
Type: Surrogate Endpoint (SUR)
Study 28958502 — Biomarker: Epidermal growth factor receptor
Type: Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: EGFR; ERBB; ERBB1; HER1
Study 25499852 — Biomarker: Superoxide dismutase Cu-Zn
Type: Pharmacodynamic Biomarker (PDY)
Genes: SOD1
Study 25499852 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 18056792 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 18056792 — Biomarker: Free fatty acids
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY)
Study 17263277 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 12728159 — Biomarker: FEV mRNA
Type: Predictive Biomarker (PRD)
Genes: FEV; PET1
Study 11590493 — Biomarker: CD4 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD4
Study 29914095 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 27893675 — Biomarker: Serum alkaline phosphatase
Type: Surrogate Endpoint (SUR)
Study 28372647 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 8005898 — Biomarker: FH mRNA
Type: Predictive Biomarker (PRD)
Genes: FH
Study 10515247 — Biomarker: Lymphocyte activation antigen CD30
Type: Predictive Biomarker (PRD)
Genes: TNFRSF8; CD30; D1S166E
Study 10515247 — Biomarker: Interleukin 1
Type: Safety Biomarker (SAF)
Study 10515247 — Biomarker: Interleukin 2
Type: Safety Biomarker (SAF)
Genes: IL2
Study 10515247 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 28658162 — Biomarker: Serum albumin
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY)
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 19164205 — Biomarker: CYP1A1 mRNA
Type: Predictive Biomarker (PRD)
Genes: CYP1A1
Study 30648677 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 27086671 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 9787651 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 9787651 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 12559482 — Biomarker: Arginine vasopressin
Type: Predictive Biomarker (PRD)
Genes: AVP; ARVP; VP
Study 19155900 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 229780 — Biomarker: Serum albumin
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY)
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 15086477 — Biomarker: Serum creatinine
Type: Surrogate Endpoint (SUR)
Study 8137524 — Biomarker: High density lipoprotein cholesterol
Type: Pharmacodynamic Biomarker (PDY)
Study 29787478 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 29787478 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 8993769 — Biomarker: TF mRNA
Type: Predictive Biomarker (PRD)
Genes: TF; PRO1400
Study 1482265 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 1482265 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 31679509 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 24932599 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 19716961 — Biomarker: FEV mRNA
Type: Predictive Biomarker (PRD)
Genes: FEV; PET1
Study 30730785 — Biomarker: Vitamin B12
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI)
Study 29573207 — Biomarker: Duration of severe neutropenia
Type: Surrogate Endpoint (SUR)
Study 29573207 — Biomarker: White blood cell
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Study 15712594 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 15712594 — Biomarker: Lactate dehydrogenase
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Study 25183507 — Biomarker: HR mRNA
Type: Predictive Biomarker (PRD)
Genes: HR
Study 25183507 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 30861351 — Biomarker: Vitamin B12
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI)
Study 22126416 — Biomarker: Immunoglobulin E
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Study 913045 — Biomarker: Plasma phenylalanine
Type: Surrogate Endpoint (SUR)
Study 6758933 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 24910199 — Biomarker: PGC mRNA
Type: Predictive Biomarker (PRD)
Genes: PGC
Study 24910199 — Biomarker: Lactate dehydrogenase
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Study 22810991 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 22810991 — Biomarker: Intercellular adhesion molecule 1
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: ICAM1
Study 12817528 — Biomarker: CYP3A4 mRNA
Type: Predictive Biomarker (PRD)
Genes: CYP3A4; CYP3A3
Study 22270216 — Biomarker: PVR mRNA
Type: Predictive Biomarker (PRD)
Genes: PVR; PVS
Study 25086653 — Biomarker: miR-122
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: MIR122
Study 25086653 — Biomarker: Glutamate dehydrogenase
Type: Safety Biomarker (SAF)
Study 22172638 — Biomarker: Interleukin 8
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: CXCL8; IL8
Study 19466245 — Biomarker: MIP mRNA
Type: Predictive Biomarker (PRD)
Genes: MIP; AQP0
Study 9667295 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 2636858 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 15233978 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 3555587 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 23434165 — Biomarker: Serum triglycerides
Type: Surrogate Endpoint (SUR)
Study 23434165 — Biomarker: Free fatty acids
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY)
Study 8407753 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 3948857 — Biomarker: Arginine vasopressin
Type: Predictive Biomarker (PRD)
Genes: AVP; ARVP; VP
Study 17288679 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 16053996 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 25449714 — Biomarker: GLP1R mRNA
Type: Predictive Biomarker (PRD)
Genes: GLP1R
Study 20102935 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 18840838 — Biomarker: D-dimer
Type: Safety Biomarker (SAF); Monitoring Biomarker (MOI)
Study 8560999 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 18581513 — Biomarker: Pyruvate dehydrogenase kinase 1
Type: Pharmacodynamic Biomarker (PDY)
Genes: PDK1; PDHK1
Study 15942580 — Biomarker: Interleukin 6
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: IL6; IFNB2
Study 15942580 — Biomarker: IL6
Type: Predictive Biomarker (PRD)
Genes: IL-6; BSF2; HGF; HSF
Study 15942580 — Biomarker: Interleukin 8
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: CXCL8; IL8
Study 15942580 — Biomarker: Interleukin 10
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: IL10
Study 8806289 — Biomarker: HR mRNA
Type: Predictive Biomarker (PRD)
Genes: HR
Study 29086614 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 26460632 — Biomarker: CP mRNA
Type: Predictive Biomarker (PRD)
Genes: CP
Study 15947501 — Biomarker: AMD1 mRNA
Type: Predictive Biomarker (PRD)
Genes: AMD1; AMD
Study 1707646 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 24273218 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 22941466 — Biomarker: ADAM8 mRNA
Type: Predictive Biomarker (PRD)
Genes: ADAM8; MS2
Study 22941466 — Biomarker: AFP mRNA
Type: Predictive Biomarker (PRD)
Genes: AFP; HPAFP
Study 18979163 — Biomarker: Bone mineral density
Type: Surrogate Endpoint (SUR)
Study 8681660 — Biomarker: CS mRNA
Type: Predictive Biomarker (PRD)
Genes: CS
Study 19100012 — Biomarker: MFSD11 mRNA
Type: Predictive Biomarker (PRD)
Genes: MFSD11; ET
Study 27320368 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 20308694 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 15739035 — Biomarker: VDR mRNA
Type: Predictive Biomarker (PRD)
Genes: VDR; NR1I1
Study 15739035 — Biomarker: Bone mineral density
Type: Surrogate Endpoint (SUR)
Study 28748002 — Biomarker: MLH1 mRNA
Type: Predictive Biomarker (PRD)
Genes: MLH1; COCA2
Study 28748002 — Biomarker: O-6-methylguanine-DNA-alkyltransferase
Type: Predictive Biomarker (PRD)
Genes: MGMT
Study 28748002 — Biomarker: Vitamin B12
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI)
Study 10792560 — Biomarker: Cyclic guanosine monophosphate
Type: Pharmacodynamic Biomarker (PDY)
Study 10792560 — Biomarker: Endothelin-1
Type: Safety Biomarker (SAF); Monitoring Biomarker (MOI)
Genes: EDN1
Study 10792560 — Biomarker: Cyclic adenosine monophosphate
Type: Pharmacodynamic Biomarker (PDY)
Study 31486356 — Biomarker: NUCB2 mRNA
Type: Predictive Biomarker (PRD)
Genes: NUCB2; NEFA
Study 24528693 — Biomarker: Serum triglycerides
Type: Surrogate Endpoint (SUR)
Study 24528693 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 19156926 — Biomarker: O-6-methylguanine-DNA-alkyltransferase
Type: Predictive Biomarker (PRD)
Genes: MGMT
Study 17227902 — Biomarker: Ovarian carcinoma antigen CA125
Type: Monitoring Biomarker (MOI)
Genes: MUC16; CA125
Study 15753495 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 2165899 — Biomarker: CRH mRNA
Type: Predictive Biomarker (PRD)
Genes: CRH
Study 31870702 — Biomarker: OCA2 mRNA
Type: Predictive Biomarker (PRD)
Genes: OCA2; D15S12; P
Study 28298393 — Biomarker: MMRN1 mRNA
Type: Predictive Biomarker (PRD)
Genes: MMRN1; ECM; EMILIN4; GPIA*; MMRN
Study 16366740 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 14668077 — Biomarker: DRD2 mRNA
Type: Predictive Biomarker (PRD)
Genes: DRD2
Study 14668077 — Biomarker: DRD2
Type: Safety Biomarker (SAF)
Study 31292644 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 31527167 — Biomarker: CDK4 mRNA
Type: Predictive Biomarker (PRD)
Genes: CDK4
Study 31527167 — Biomarker: PDCD1
Type: Safety Biomarker (SAF)
Genes: CD279; PD1; hSLE1; PD-1
Study 31527167 — Biomarker: FGFR2 mRNA
Type: Predictive Biomarker (PRD)
Genes: FGFR2; BEK; KGFR; KSAM
Study 31527167 — Biomarker: ERBB3 mRNA
Type: Predictive Biomarker (PRD)
Genes: ERBB3; HER3
Study 12873921 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 20975461 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 20975461 — Biomarker: MMP-1
Type: Safety Biomarker (SAF)
Genes: MMP1
Study 12971422 — Biomarker: FH mRNA
Type: Predictive Biomarker (PRD)
Genes: FH
Study 29658440 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 25249415 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 25249415 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 22251435 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 22251435 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 28704492 — Biomarker: Matrix metalloproteinase 9
Type: Pharmacodynamic Biomarker (PDY)
Genes: MMP9; CLG4B
Study 28704492 — Biomarker: Metalloproteinase inhibitor 1
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: TIMP1; CLGI; TIMP
Study 23584289 — Biomarker: Nuclear factor erythroid 2-related factor 2
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: NFE2L2; NRF2
Study 23584289 — Biomarker: GCLC mRNA
Type: Predictive Biomarker (PRD)
Genes: GCLC; GLCL; GLCLC
Study 23584289 — Biomarker: Nqo1 mRNA
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY)
Genes: NQO1; DIA4; NMOR1
Study 23584289 — Biomarker: miR-21
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: MIR21
Study 23584289 — Biomarker: miR-30e
Type: Safety Biomarker (SAF)
Genes: MIR30E
Study 21721593 — Biomarker: SHBG mRNA
Type: Predictive Biomarker (PRD)
Genes: SHBG
Study 21721593 — Biomarker: SERPINA6 mRNA
Type: Predictive Biomarker (PRD)
Genes: SERPINA6; CBG
Study 21721593 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 21721593 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 21721593 — Biomarker: D-dimer
Type: Safety Biomarker (SAF); Monitoring Biomarker (MOI)
Study 19081394 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 15295717 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 15295717 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 26630643 — Biomarker: High density lipoprotein cholesterol
Type: Pharmacodynamic Biomarker (PDY)
Study 8562400 — Biomarker: von Willebrand factor
Type: Safety Biomarker (SAF)
Genes: VWF; F8VWF
Study 8562400 — Biomarker: D-dimer
Type: Safety Biomarker (SAF); Monitoring Biomarker (MOI)
Study 25539757 — Biomarker: Homovanillic acid
Type: Pharmacodynamic Biomarker (PDY)
Study 15829533 — Biomarker: Exhaled nitric oxide
Type: Predictive Biomarker (PRD)
Study 12860943 — Biomarker: AR mRNA
Type: Predictive Biomarker (PRD)
Genes: AR; DHTR; NR3C4
Study 9282581 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 22011640 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 20329618 — Biomarker: OSM mRNA
Type: Predictive Biomarker (PRD)
Genes: OSM
Study 11594407 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 11594407 — Biomarker: High density lipoprotein cholesterol
Type: Pharmacodynamic Biomarker (PDY)
Study 7527565 — Biomarker: Homovanillic acid
Type: Pharmacodynamic Biomarker (PDY)
Study 26488347 — Biomarker: SI mRNA
Type: Predictive Biomarker (PRD)
Genes: SI
Study 31712335 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 26812515 — Biomarker: Serum albumin
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY)
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 24448644 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 18021336 — Biomarker: CYP3A4 mRNA
Type: Predictive Biomarker (PRD)
Genes: CYP3A4; CYP3A3
Study 3793199 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 7705196 — Biomarker: SI mRNA
Type: Predictive Biomarker (PRD)
Genes: SI
Study 18940387 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 2481772 — Biomarker: CAP1 mRNA
Type: Predictive Biomarker (PRD)
Genes: CAP1; CAP
Study 2481772 — Biomarker: HR mRNA
Type: Predictive Biomarker (PRD)
Genes: HR
Study 2481772 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 236075 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 31419298 — Biomarker: CD34 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD34
Study 31419298 — Biomarker: Epidermal growth factor receptor
Type: Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: EGFR; ERBB; ERBB1; HER1
Study 31419298 — Biomarker: TP53
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: p53; LFS1
Study 31419298 — Biomarker: H3-3A mRNA
Type: Predictive Biomarker (PRD)
Genes: H3-3A; H3.3A; H3F3; H3F3A; PP781;; H3-3B; H3.3B; H3F3B
Study 31419298 — Biomarker: Ki-67
Type: Predictive Biomarker (PRD)
Genes: MKI67; MIB-1; PPP1R105
Study 21421502 — Biomarker: D-dimer
Type: Safety Biomarker (SAF); Monitoring Biomarker (MOI)
Study 11252116 — Biomarker: D-dimer
Type: Safety Biomarker (SAF); Monitoring Biomarker (MOI)
Study 22142891 — Biomarker: FCGR3B
Type: Predictive Biomarker (PRD)
Genes: CD16; CD16b; FcgammaRIIIb; FcRIIIb
Study 8958191 — Biomarker: Natriuretic peptides A
Type: Safety Biomarker (SAF)
Genes: NPPA; ANP; PND
Study 22613001 — Biomarker: EPX mRNA
Type: Predictive Biomarker (PRD)
Genes: EPX; EPER; EPO; EPP
Study 19551536 — Biomarker: IGFALS mRNA
Type: Predictive Biomarker (PRD)
Genes: IGFALS; ALS
Study 17935245 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 17935245 — Biomarker: Interleukin 6
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: IL6; IFNB2
Study 2112022 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 21330636 — Biomarker: Gastric inhibitory polypeptide
Type: Pharmacodynamic Biomarker (PDY)
Genes: GIP
Study 21330636 — Biomarker: Free fatty acids
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY)
Study 18637139 — Biomarker: NPEPPS mRNA
Type: Predictive Biomarker (PRD)
Genes: NPEPPS; PSA
Study 14717388 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 3020703 — Biomarker: CAV1 mRNA
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: CAV1; CAV
Study 24998403 — Biomarker: Heat pain threshold
Type: Pharmacodynamic Biomarker (PDY)
Study 19358495 — Biomarker: SI mRNA
Type: Predictive Biomarker (PRD)
Genes: SI
Study 22592178 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 12535822 — Biomarker: CD40 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD40; TNFRSF5