AIM-Harvard/TrialPanorama-filtered huggingface dataset:
Study 19153936 — Biomarker: High density lipoprotein cholesterol
Type: Pharmacodynamic Biomarker (PDY)
Study 19153936 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 24509962 — Biomarker: AGA mRNA
Type: Predictive Biomarker (PRD)
Genes: AGA
Study 7641720 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 2475699 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 26579797 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 26579797 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 21787474 — Biomarker: CD4 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD4
Study 17014519 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 17014519 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 26451734 — Biomarker: CAT mRNA
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: CAT
Study 20438516 — Biomarker: Cell-free DNA
Type: Monitoring Biomarker (MOI)
Study 12356379 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 23255849 — Biomarker: MB mRNA
Type: Predictive Biomarker (PRD)
Genes: MB
Study 2698947 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 31796521 — Biomarker: TF mRNA
Type: Predictive Biomarker (PRD)
Genes: TF; PRO1400
Study 19454879 — Biomarker: LBP mRNA
Type: Predictive Biomarker (PRD)
Genes: LBP
Study 17444886 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 31264032 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 24218465 — Biomarker: LOX mRNA
Type: Predictive Biomarker (PRD)
Genes: LOX
Study 24218465 — Biomarker: TH mRNA
Type: Predictive Biomarker (PRD)
Genes: TH; TYH
Study 15636225 — Biomarker: Vitamin B12
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI)
Study 7898595 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 28160190 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 22842478 — Biomarker: Forkhead box protein P3
Type: Predictive Biomarker (PRD)
Genes: FOXP3; IPEX; JM2
Study 22842478 — Biomarker: APOA1 mRNA
Type: Predictive Biomarker (PRD)
Genes: APOA1
Study 22842478 — Biomarker: CCL17 mRNA
Type: Predictive Biomarker (PRD)
Genes: CCL17; SCYA17; TARC
Study 22842478 — Biomarker: HLA-A
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Study 24444988 — Biomarker: Superoxide dismutase Cu-Zn
Type: Pharmacodynamic Biomarker (PDY)
Genes: SOD1
Study 23646099 — Biomarker: DDC mRNA
Type: Predictive Biomarker (PRD)
Genes: DDC; AADC
Study 23646099 — Biomarker: Homovanillic acid
Type: Pharmacodynamic Biomarker (PDY)
Study 18080043 — Biomarker: FMOD mRNA
Type: Predictive Biomarker (PRD)
Genes: FMOD; FM; SLRR2E
Study 16805716 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 1627756 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 1627756 — Biomarker: Serum potassium
Type: Surrogate Endpoint (SUR)
Study 11579363 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 30623490 — Biomarker: CD22 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD22; SIGLEC2
Study 27943397 — Biomarker: Thiopurine S-methyltransferase
Type: Safety Biomarker (SAF)
Genes: TPMT
Study 24089534 — Biomarker: Cardiac troponin T
Type: Safety Biomarker (SAF)
Genes: TNNT2
Study 24089534 — Biomarker: B-type natriuretic peptide
Type: Safety Biomarker (SAF)
Genes: NPPB
Study 7359503 — Biomarker: DES mRNA
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: DES
Study 8393606 — Biomarker: Neutralizing antibody
Type: Surrogate Endpoint (SUR)
Study 3578925 — Biomarker: CDCA4 mRNA
Type: Predictive Biomarker (PRD)
Genes: CDCA4; HEPP
Study 27619403 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 27619403 — Biomarker: Serum triglycerides
Type: Surrogate Endpoint (SUR)
Study 23511706 — Biomarker: HR mRNA
Type: Predictive Biomarker (PRD)
Genes: HR
Study 23511706 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 21508826 — Biomarker: CYP3A4 mRNA
Type: Predictive Biomarker (PRD)
Genes: CYP3A4; CYP3A3
Study 21508826 — Biomarker: CYP2B6 mRNA
Type: Predictive Biomarker (PRD)
Genes: CYP2B6
Study 15593207 — Biomarker: Serum creatinine
Type: Surrogate Endpoint (SUR)
Study 26225500 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 18706028 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 9682028 — Biomarker: WWTR1 mRNA
Type: Predictive Biomarker (PRD)
Genes: WWTR1; TAZ
Study 17377770 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 23048052 — Biomarker: GPI mRNA
Type: Predictive Biomarker (PRD)
Genes: GPI
Study 6841304 — Biomarker: HBV DNA
Type: Monitoring Biomarker (MOI)
Study 30058646 — Biomarker: PC mRNA
Type: Predictive Biomarker (PRD)
Genes: PC
Study 30058646 — Biomarker: GGT1 mRNA
Type: Predictive Biomarker (PRD)
Genes: GGT1; GGT
Study 26177791 — Biomarker: TNFRSF11B mRNA
Type: Predictive Biomarker (PRD)
Genes: TNFRSF11B; OCIF; OPG
Study 26177791 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 26177791 — Biomarker: Bone mineral density
Type: Surrogate Endpoint (SUR)
Study 20150883 — Biomarker: SI mRNA
Type: Predictive Biomarker (PRD)
Genes: SI
Study 11788634 — Biomarker: SHBG mRNA
Type: Predictive Biomarker (PRD)
Genes: SHBG
Study 7781864 — Biomarker: GNRH1 mRNA
Type: Predictive Biomarker (PRD)
Genes: GNRH1; GNRH; GRH; LHRH
Study 1754636 — Biomarker: REM1 mRNA
Type: Predictive Biomarker (PRD)
Genes: REM1; GES; REM
Study 27333382 — Biomarker: HBV DNA
Type: Monitoring Biomarker (MOI)
Study 17720098 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 17720098 — Biomarker: Interleukin 6
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: IL6; IFNB2
Study 17720098 — Biomarker: White blood cell
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Study 7979533 — Biomarker: Forced vital capacity
Type: Surrogate Endpoint (SUR)
Study 29061728 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 26867335 — Biomarker: Serum albumin
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY)
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 26867335 — Biomarker: White blood cell
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Study 21931204 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 21931204 — Biomarker: Interleukin 1
Type: Safety Biomarker (SAF)
Study 18240965 — Biomarker: CD4 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD4
Study 7032347 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 21318315 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 15368110 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 15368110 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 9519853 — Biomarker: Serum alkaline phosphatase
Type: Surrogate Endpoint (SUR)
Study 2801555 — Biomarker: MB mRNA
Type: Predictive Biomarker (PRD)
Genes: MB
Study 822858 — Biomarker: TRH mRNA
Type: Predictive Biomarker (PRD)
Genes: TRH
Study 29137842 — Biomarker: Cytochrome P450 2C19
Type: Safety Biomarker (SAF)
Genes: CYP2C19
Study 29137842 — Biomarker: CYP1A2 mRNA
Type: Predictive Biomarker (PRD)
Genes: CYP1A2
Study 29137842 — Biomarker: CYP2C9 mRNA
Type: Predictive Biomarker (PRD)
Genes: CYP2C9; CYP2C10
Study 29137842 — Biomarker: Cytochrome P450 2D6
Type: Safety Biomarker (SAF)
Genes: CYP2D6; CYP2DL1
Study 29137842 — Biomarker: CYP3A4 mRNA
Type: Predictive Biomarker (PRD)
Genes: CYP3A4; CYP3A3
Study 15637764 — Biomarker: CD4 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD4
Study 15637764 — Biomarker: Interleukin 2
Type: Safety Biomarker (SAF)
Genes: IL2
Study 12394376 — Biomarker: Interleukin 2
Type: Safety Biomarker (SAF)
Genes: IL2
Study 12394376 — Biomarker: Interleukin 6
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: IL6; IFNB2
Study 12394376 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 31171755 — Biomarker: Complement C5
Type: Pharmacodynamic Biomarker (PDY)
Genes: C5; CPAMD4
Study 15967849 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 12581487 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 12581487 — Biomarker: Interleukin 1
Type: Safety Biomarker (SAF)
Study 9091475 — Biomarker: Interferon gamma
Type: Safety Biomarker (SAF); Monitoring Biomarker (MOI)
Genes: IFNG
Study 9091475 — Biomarker: DCN mRNA
Type: Predictive Biomarker (PRD)
Genes: DCN; SLRR1B
Study 7690364 — Biomarker: TBXT mRNA
Type: Predictive Biomarker (PRD)
Genes: TBXT; T
Study 30324422 — Biomarker: Estrogen receptor
Type: Predictive Biomarker (PRD)
Genes: ESR1; ESR; NR3A1
Study 20529805 — Biomarker: Leukocyte surface antigen Leu-16
Type: Predictive Biomarker (PRD)
Genes: MS4A1; CD20
Study 8706447 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 28168203 — Biomarker: Platelet glycoprotein 4
Type: Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY)
Genes: CD36; GP3B; GP4
Study 24034909 — Biomarker: PIP mRNA
Type: Predictive Biomarker (PRD)
Genes: PIP; GCDFP15; GPIP4
Study 21357860 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 9883763 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 2915293 — Biomarker: Complement C3
Type: Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: C3; CPAMD1
Study 2915293 — Biomarker: Forced vital capacity
Type: Surrogate Endpoint (SUR)
Study 27039291 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 15505001 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 7918139 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 29374674 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 29374674 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 21645639 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 17046324 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 17046324 — Biomarker: High density lipoprotein cholesterol
Type: Pharmacodynamic Biomarker (PDY)
Study 17046324 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 28222574 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 20423964 — Biomarker: Cervical intraepithelial neoplasia
Type: Surrogate Endpoint (SUR)
Study 16860169 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 12623974 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 31219517 — Biomarker: Erbb2 tyrosine kinase receptor
Type: Predictive Biomarker (PRD)
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 21884958 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 25265874 — Biomarker: SLC10A3 mRNA
Type: Predictive Biomarker (PRD)
Genes: SLC10A3; DXS253E; P3
Study 19356389 — Biomarker: CYP3A4 mRNA
Type: Predictive Biomarker (PRD)
Genes: CYP3A4; CYP3A3
Study 20471234 — Biomarker: PC mRNA
Type: Predictive Biomarker (PRD)
Genes: PC
Study 8915668 — Biomarker: Granulocyte-macrophage colony-stimulating factor
Type: Safety Biomarker (SAF)
Genes: CSF2; GMCSF
Study 27483064 — Biomarker: B-type natriuretic peptide
Type: Safety Biomarker (SAF)
Genes: NPPB
Study 25197833 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 19604249 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 8261939 — Biomarker: Forced vital capacity
Type: Surrogate Endpoint (SUR)
Study 3766413 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 25649018 — Biomarker: NPEPPS mRNA
Type: Predictive Biomarker (PRD)
Genes: NPEPPS; PSA
Study 25649018 — Biomarker: KLK2 mRNA
Type: Predictive Biomarker (PRD)
Genes: KLK2
Study 25649018 — Biomarker: LGALS8 mRNA
Type: Predictive Biomarker (PRD)
Genes: LGALS8
Study 25649018 — Biomarker: LGALS3 mRNA
Type: Predictive Biomarker (PRD)
Genes: LGALS3; MAC2
Study 25649018 — Biomarker: Lactate dehydrogenase
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Study 24009294 — Biomarker: SPR mRNA
Type: Predictive Biomarker (PRD)
Genes: SPR
Study 24009294 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 24009294 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 24009294 — Biomarker: Serum creatinine
Type: Surrogate Endpoint (SUR)
Study 24009294 — Biomarker: Serum potassium
Type: Surrogate Endpoint (SUR)
Study 14761120 — Biomarker: EMD mRNA
Type: Predictive Biomarker (PRD)
Genes: EMD; EDMD; STA
Study 22544016 — Biomarker: NES mRNA
Type: Predictive Biomarker (PRD)
Genes: NES; Nbla00170
Study 9178345 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 25005017 — Biomarker: PC mRNA
Type: Predictive Biomarker (PRD)
Genes: PC
Study 16610924 — Biomarker: Adenosine deaminase
Type: Monitoring Biomarker (MOI)
Genes: ADA; ADA1
Study 16610924 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 30822621 — Biomarker: Erbb2 tyrosine kinase receptor
Type: Predictive Biomarker (PRD)
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 28946838 — Biomarker: Hyaluronic acid
Type: Safety Biomarker (SAF)
Study 2224165 — Biomarker: Interleukin 2
Type: Safety Biomarker (SAF)
Genes: IL2
Study 2224165 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 445326 — Biomarker: White blood cell
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Study 31108227 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 24015915 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 12361204 — Biomarker: Intercellular adhesion molecule 1
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: ICAM1
Study 10516870 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 7711988 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 2791449 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 18565522 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 11377154 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 28486043 — Biomarker: DNMT3A mRNA
Type: Predictive Biomarker (PRD)
Genes: DNMT3A
Study 10904458 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 10904458 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 18175062 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 18175062 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 16455629 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 16455629 — Biomarker: Interleukin 2
Type: Safety Biomarker (SAF)
Genes: IL2
Study 1621888 — Biomarker: Glucose-6-phosphate dehydrogenase
Type: Safety Biomarker (SAF)
Genes: G6PD
Study 19731013 — Biomarker: Hormone receptor
Type: Predictive Biomarker (PRD)
Study 7774139 — Biomarker: White blood cell
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Study 23982478 — Biomarker: MSC mRNA
Type: Predictive Biomarker (PRD)
Genes: MSC; ABF1; BHLHA22
Study 11678967 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 9196416 — Biomarker: MB mRNA
Type: Predictive Biomarker (PRD)
Genes: MB
Study 20188627 — Biomarker: EP300 mRNA
Type: Predictive Biomarker (PRD)
Genes: EP300; P300
Study 17970786 — Biomarker: HDC mRNA
Type: Predictive Biomarker (PRD)
Genes: HDC
Study 15997634 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 15997634 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 6336977 — Biomarker: TF mRNA
Type: Predictive Biomarker (PRD)
Genes: TF; PRO1400
Study 23364035 — Biomarker: Serum albumin
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY)
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 9690571 — Biomarker: Eosinophil cationic protein
Type: Safety Biomarker (SAF)
Genes: RNASE3; ECP; RNS3
Study 30630742 — Biomarker: Interleukin 6
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: IL6; IFNB2
Study 30669181 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 19683590 — Biomarker: FEV mRNA
Type: Predictive Biomarker (PRD)
Genes: FEV; PET1
Study 11939919 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 7626351 — Biomarker: von Willebrand factor
Type: Safety Biomarker (SAF)
Genes: VWF; F8VWF
Study 7626351 — Biomarker: D-dimer
Type: Safety Biomarker (SAF); Monitoring Biomarker (MOI)
Study 12147804 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 12147804 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 10218753 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 402800 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 22396248 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 16731539 — Biomarker: GNRH1 mRNA
Type: Predictive Biomarker (PRD)
Genes: GNRH1; GNRH; GRH; LHRH
Study 16731539 — Biomarker: Hormone receptor
Type: Predictive Biomarker (PRD)
Study 9037322 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 18487001 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 2687639 — Biomarker: TG mRNA
Type: Predictive Biomarker (PRD)
Genes: TG
Study 2687639 — Biomarker: High density lipoprotein cholesterol
Type: Pharmacodynamic Biomarker (PDY)
Study 2687639 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 27730425 — Biomarker: Vascular endothelial growth factor
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY)
Study 19634161 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 19634161 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 17526165 — Biomarker: T-lymphocyte activation antigen CD86
Type: Pharmacodynamic Biomarker (PDY)
Genes: CD86; CD28LG2
Study 17526165 — Biomarker: CD80 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD80; CD28LG; CD28LG1; LAB7
Study 17526165 — Biomarker: CD40 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD40; TNFRSF5
Study 17526165 — Biomarker: CD14 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD14
Study 30567490 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 23575360 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 9288279 — Biomarker: TNS1 mRNA
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: TNS1; TNS
Study 3535002 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 15276504 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 31880993 — Biomarker: Gastric inhibitory polypeptide
Type: Pharmacodynamic Biomarker (PDY)
Genes: GIP
Study 26732282 — Biomarker: Superoxide dismutase Cu-Zn
Type: Pharmacodynamic Biomarker (PDY)
Genes: SOD1
Study 24504222 — Biomarker: Serum albumin
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY)
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 22425161 — Biomarker: EVL mRNA
Type: Predictive Biomarker (PRD)
Genes: EVL; RNB6
Study 16230259 — Biomarker: SFPQ mRNA
Type: Predictive Biomarker (PRD)
Genes: SFPQ; PSF
Study 623136 — Biomarker: Serum triglycerides
Type: Surrogate Endpoint (SUR)
Study 623136 — Biomarker: Serum uric acid
Type: Surrogate Endpoint (SUR)
Study 623136 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 25842725 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 20884007 — Biomarker: FH mRNA
Type: Predictive Biomarker (PRD)
Genes: FH
Study 20884007 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 19349630 — Biomarker: Exhaled carbon monoxide
Type: Surrogate Endpoint (SUR)
Study 9682356 — Biomarker: CD4 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD4
Study 31744119 — Biomarker: Nerve growth factor
Type: Predictive Biomarker (PRD)
Genes: NGF; NGFB
Study 31744119 — Biomarker: BDNF
Type: Safety Biomarker (SAF)
Study 26434651 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 26434651 — Biomarker: High density lipoprotein cholesterol
Type: Pharmacodynamic Biomarker (PDY)
Study 26434651 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 17327378 — Biomarker: PPARA mRNA
Type: Predictive Biomarker (PRD)
Genes: PPARA; NR1C1; PPAR
Study 17327378 — Biomarker: Peroxisome proliferator-activated receptor alpha
Type: Safety Biomarker (SAF)
Genes: PPARA
Study 15642026 — Biomarker: Probing pocket depth
Type: Surrogate Endpoint (SUR)
Study 30507711 — Biomarker: SHBG mRNA
Type: Predictive Biomarker (PRD)
Genes: SHBG
Study 30507711 — Biomarker: TFPI mRNA
Type: Predictive Biomarker (PRD)
Genes: TFPI; LACI; TFPI1
Study 30507711 — Biomarker: APC mRNA
Type: Predictive Biomarker (PRD)
Genes: APC; DP2.5
Study 30507711 — Biomarker: Blood coagulation
Type: Pharmacodynamic Biomarker (PDY)
Study 27806355 — Biomarker: Intact parathyroid hormone
Type: Predictive Biomarker (PRD)
Study 27806355 — Biomarker: Fibroblast growth factor 23
Type: Pharmacodynamic Biomarker (PDY)
Genes: FGF23; HYPF; UNQ3027/PRO9828
Study 27806355 — Biomarker: Serum calcium
Type: Surrogate Endpoint (SUR)
Study 25372006 — Biomarker: MAL mRNA
Type: Predictive Biomarker (PRD)
Genes: MAL
Study 8519720 — Biomarker: Forced vital capacity
Type: Surrogate Endpoint (SUR)
Study 6763833 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)