AIM-Harvard/TrialPanorama-filtered huggingface dataset:
Study 19618992 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 19618992 — Biomarker: High density lipoprotein cholesterol
Type: Pharmacodynamic Biomarker (PDY)
Study 9700881 — Biomarker: CD72 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD72
Study 9700881 — Biomarker: FCGR3B
Type: Predictive Biomarker (PRD)
Genes: CD16; CD16b; FcgammaRIIIb; FcRIIIb
Study 24378599 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 9650682 — Biomarker: POMC
Type: Predictive Biomarker (PRD)
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 8135428 — Biomarker: Serum phosphate
Type: Pharmacodynamic Biomarker (PDY)
Study 31015261 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 25620313 — Biomarker: STS mRNA
Type: Predictive Biomarker (PRD)
Genes: STS; ARSC1
Study 17547798 — Biomarker: High density lipoprotein cholesterol
Type: Pharmacodynamic Biomarker (PDY)
Study 17547798 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 17547798 — Biomarker: Serum triglycerides
Type: Surrogate Endpoint (SUR)
Study 15337732 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 3294285 — Biomarker: HR mRNA
Type: Predictive Biomarker (PRD)
Genes: HR
Study 31665619 — Biomarker: BDNF
Type: Safety Biomarker (SAF)
Study 23919955 — Biomarker: DST mRNA
Type: Predictive Biomarker (PRD)
Genes: DST; BP230; BP240; BPAG1; DMH; DT; KIAA0728
Study 8887015 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 29526860 — Biomarker: MAL mRNA
Type: Predictive Biomarker (PRD)
Genes: MAL
Study 10621930 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 8637188 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 8637188 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 28137754 — Biomarker: POR mRNA
Type: Predictive Biomarker (PRD)
Genes: POR; CYPOR
Study 28137754 — Biomarker: AMH mRNA
Type: Predictive Biomarker (PRD)
Genes: AMH; MIF
Study 22242343 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 19822956 — Biomarker: SLC2A1 mRNA
Type: Predictive Biomarker (PRD)
Genes: SLC2A1; GLUT1
Study 30661477 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 17917992 — Biomarker: GAD1 mRNA
Type: Predictive Biomarker (PRD)
Genes: GAD1; GAD; GAD67
Study 9552221 — Biomarker: Interleukin 8
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: CXCL8; IL8
Study 19951554 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 15199365 — Biomarker: Peroxisome proliferator-activated receptor alpha
Type: Safety Biomarker (SAF)
Genes: PPARA
Study 729619 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 26347398 — Biomarker: Eosinophil cationic protein
Type: Safety Biomarker (SAF)
Genes: RNASE3; ECP; RNS3
Study 19111408 — Biomarker: ESR2 mRNA
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: ESR2; ESTRB; NR3A2
Study 19111408 — Biomarker: Estrogen receptor
Type: Predictive Biomarker (PRD)
Genes: ESR1; ESR; NR3A1
Study 15310737 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 9695137 — Biomarker: CRH mRNA
Type: Predictive Biomarker (PRD)
Genes: CRH
Study 9893070 — Biomarker: Bone mineral density
Type: Surrogate Endpoint (SUR)
Study 21551507 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 19958629 — Biomarker: TP53
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: p53; LFS1
Study 9505774 — Biomarker: Pulmonary vascular resistance
Type: Surrogate Endpoint (SUR)
Study 8541002 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 8541002 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 8541002 — Biomarker: Serum creatinine
Type: Surrogate Endpoint (SUR)
Study 31957666 — Biomarker: Vascular endothelial growth factor A
Type: Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: VEGFA; VEGF
Study 31957666 — Biomarker: Vascular endothelial growth factor
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY)
Study 31708410 — Biomarker: PCSK9 mRNA
Type: Predictive Biomarker (PRD)
Genes: PCSK9; NARC1; PSEC0052
Study 31708410 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 26004431 — Biomarker: MATE1
Type: Safety Biomarker (SAF)
Genes: SLC47A1; FLJ10847
Study 26004431 — Biomarker: SLC47A1 mRNA
Type: Predictive Biomarker (PRD)
Genes: SLC47A1; MATE1
Study 29588232 — Biomarker: Interleukin 6
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: IL6; IFNB2
Study 29588232 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 21038650 — Biomarker: HBV DNA
Type: Monitoring Biomarker (MOI)
Study 21038650 — Biomarker: IL4
Type: Safety Biomarker (SAF)
Genes: BSF1; IL-4; BCGF1; BCGF-1; MGC79402
Study 21038650 — Biomarker: Interferon gamma
Type: Safety Biomarker (SAF); Monitoring Biomarker (MOI)
Genes: IFNG
Study 19066345 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 7596125 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 31063 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 24600204 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 22257505 — Biomarker: MIP mRNA
Type: Predictive Biomarker (PRD)
Genes: MIP; AQP0
Study 22257505 — Biomarker: Forced vital capacity
Type: Surrogate Endpoint (SUR)
Study 15993359 — Biomarker: GAD2 mRNA
Type: Predictive Biomarker (PRD)
Genes: GAD2; GAD65
Study 15993359 — Biomarker: CD4 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD4
Study 15993359 — Biomarker: Interleukin 2 receptor alpha
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: IL2RA
Study 11485375 — Biomarker: PAH mRNA
Type: Predictive Biomarker (PRD)
Genes: PAH
Study 9988537 — Biomarker: Ki-67
Type: Predictive Biomarker (PRD)
Genes: MKI67; MIB-1; PPP1R105
Study 26460291 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 19363330 — Biomarker: Bone mineral density
Type: Surrogate Endpoint (SUR)
Study 3211079 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 20979799 — Biomarker: Forced vital capacity
Type: Surrogate Endpoint (SUR)
Study 12461499 — Biomarker: Serum albumin
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY)
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 31544378 — Biomarker: OCA2 mRNA
Type: Predictive Biomarker (PRD)
Genes: OCA2; D15S12; P
Study 24777811 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 24777811 — Biomarker: CD34 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD34
Study 24777811 — Biomarker: Vascular endothelial growth factor receptor 2
Type: Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY)
Genes: KDR; FLK1; VEGFR2
Study 24659566 — Biomarker: Eosinophil cationic protein
Type: Safety Biomarker (SAF)
Genes: RNASE3; ECP; RNS3
Study 8677931 — Biomarker: HP mRNA
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: HP
Study 6121479 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 27550386 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 25720388 — Biomarker: 5'-AMP-activated protein kinase subunit beta-1
Type: Pharmacodynamic Biomarker (PDY)
Genes: PRKAB1; AMPK
Study 17520986 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 12368393 — Biomarker: FOS mRNA
Type: Predictive Biomarker (PRD)
Genes: FOS; G0S7
Study 21214718 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 21214718 — Biomarker: B-type natriuretic peptide
Type: Safety Biomarker (SAF)
Genes: NPPB
Study 12924169 — Biomarker: Serum uric acid
Type: Surrogate Endpoint (SUR)
Study 3838625 — Biomarker: MB mRNA
Type: Predictive Biomarker (PRD)
Genes: MB
Study 3838625 — Biomarker: FMN1 mRNA
Type: Predictive Biomarker (PRD)
Genes: FMN1; FMN; LD
Study 3838625 — Biomarker: Lactate dehydrogenase
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Study 31870634 — Biomarker: Bone mineral density
Type: Surrogate Endpoint (SUR)
Study 16051882 — Biomarker: ALDH2 mRNA
Type: Predictive Biomarker (PRD)
Genes: ALDH2; ALDM
Study 10404451 — Biomarker: Serum creatinine
Type: Surrogate Endpoint (SUR)
Study 6798382 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 27664002 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 21057005 — Biomarker: Interleukin 13
Type: Predictive Biomarker (PRD); Monitoring Biomarker (MOI)
Genes: IL13; NC30
Study 15045594 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 31008935 — Biomarker: MBP mRNA
Type: Predictive Biomarker (PRD)
Genes: MBP
Study 31008935 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 27376418 — Biomarker: TBXT mRNA
Type: Predictive Biomarker (PRD)
Genes: TBXT; T
Study 27376418 — Biomarker: HGS mRNA
Type: Predictive Biomarker (PRD)
Genes: HGS; HRS
Study 21839414 — Biomarker: ACD mRNA
Type: Predictive Biomarker (PRD)
Genes: ACD; PIP1; PTOP; TINT1; TPP1
Study 19810001 — Biomarker: PAH mRNA
Type: Predictive Biomarker (PRD)
Genes: PAH
Study 15231444 — Biomarker: Interleukin 2
Type: Safety Biomarker (SAF)
Genes: IL2
Study 3028457 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 27027897 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 27027897 — Biomarker: CD4 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD4
Study 16169328 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 8974970 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 19198268 — Biomarker: Superoxide dismutase Cu-Zn
Type: Pharmacodynamic Biomarker (PDY)
Genes: SOD1
Study 15637467 — Biomarker: Beta-2-microglobulin
Type: Safety Biomarker (SAF)
Genes: B2M; CDABP0092; HDCMA22P
Study 15637467 — Biomarker: Urinary microalbumin
Type: Safety Biomarker (SAF)
Study 10708814 — Biomarker: POMC
Type: Predictive Biomarker (PRD)
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 6873137 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 22313885 — Biomarker: Serum albumin
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY)
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 31860537 — Biomarker: Serum calcium
Type: Surrogate Endpoint (SUR)
Study 16105869 — Biomarker: ACR mRNA
Type: Predictive Biomarker (PRD)
Genes: ACR; ACRS
Study 16105869 — Biomarker: CD4 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD4
Study 21168112 — Biomarker: SP6 mRNA
Type: Predictive Biomarker (PRD)
Genes: SP6; KLF14
Study 12381902 — Biomarker: Thymidylate synthase 
Type: Predictive Biomarker (PRD)
Genes: TYMS; TS; OK/SW-cl.29
Study 8524988 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 2177158 — Biomarker: POMC
Type: Predictive Biomarker (PRD)
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 2177158 — Biomarker: Mismatch negativity
Type: Pharmacodynamic Biomarker (PDY)
Study 20922557 — Biomarker: Erbb2 tyrosine kinase receptor
Type: Predictive Biomarker (PRD)
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 11052308 — Biomarker: POMC
Type: Predictive Biomarker (PRD)
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 11052308 — Biomarker: NTM mRNA
Type: Predictive Biomarker (PRD)
Genes: NTM; IGLON2; NT; UNQ297/PRO337
Study 18786318 — Biomarker: D-dimer
Type: Safety Biomarker (SAF); Monitoring Biomarker (MOI)
Study 14703408 — Biomarker: TP53
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: p53; LFS1
Study 9295106 — Biomarker: POMC
Type: Predictive Biomarker (PRD)
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 7956624 — Biomarker: Plasminogen activator inhibitor
Type: Safety Biomarker (SAF)
Genes: SERPINE1; PAI1; PLANH1
Study 31051506 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 30247596 — Biomarker: CD4 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD4
Study 30247596 — Biomarker: Interleukin 2
Type: Safety Biomarker (SAF)
Genes: IL2
Study 30247596 — Biomarker: Interferon gamma
Type: Safety Biomarker (SAF); Monitoring Biomarker (MOI)
Genes: IFNG
Study 21456104 — Biomarker: GAD1 mRNA
Type: Predictive Biomarker (PRD)
Genes: GAD1; GAD; GAD67
Study 25125505 — Biomarker: SLC2A4 mRNA
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: SLC2A4; GLUT4
Study 25125505 — Biomarker: Interleukin 6
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: IL6; IFNB2
Study 22913248 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 22913248 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 16140428 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 11947910 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 27718765 — Biomarker: Interleukin 2
Type: Safety Biomarker (SAF)
Genes: IL2
Study 27718765 — Biomarker: Interleukin 6
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: IL6; IFNB2
Study 27718765 — Biomarker: Interleukin 8
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: CXCL8; IL8
Study 27718765 — Biomarker: IL4 mRNA
Type: Monitoring Biomarker (MOI)
Genes: IL4
Study 27718765 — Biomarker: Interleukin 10
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: IL10
Study 3720176 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 28631582 — Biomarker: SLC2A4 mRNA
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: SLC2A4; GLUT4
Study 23515614 — Biomarker: CCND1
Type: Predictive Biomarker (PRD)
Genes: U21B31
Study 10978398 — Biomarker: Beta-2-microglobulin
Type: Safety Biomarker (SAF)
Genes: B2M; CDABP0092; HDCMA22P
Study 31483910 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 31483910 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 31483910 — Biomarker: ATF4 mRNA
Type: Predictive Biomarker (PRD)
Genes: ATF4; CREB2; TXREB
Study 31483910 — Biomarker: ATF6 mRNA
Type: Predictive Biomarker (PRD)
Genes: ATF6
Study 31483910 — Biomarker: DDIT3 mRNA
Type: Predictive Biomarker (PRD)
Genes: DDIT3; CHOP; CHOP10; GADD153
Study 31483910 — Biomarker: HSPA5 mRNA
Type: Predictive Biomarker (PRD)
Genes: HSPA5; GRP78
Study 31483910 — Biomarker: XBP1 mRNA
Type: Predictive Biomarker (PRD)
Genes: XBP1; TREB5; XBP2
Study 26290682 — Biomarker: LPO mRNA
Type: Predictive Biomarker (PRD)
Genes: LPO; SAPX
Study 18400716 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 10409200 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 29469046 — Biomarker: Serum creatinine
Type: Surrogate Endpoint (SUR)
Study 16197659 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 16197659 — Biomarker: High density lipoprotein cholesterol
Type: Pharmacodynamic Biomarker (PDY)
Study 11998963 — Biomarker: Serum triglycerides
Type: Surrogate Endpoint (SUR)
Study 28427806 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 24598948 — Biomarker: Cardiac troponin I
Type: Safety Biomarker (SAF)
Genes: TNNI3; TNNC1
Study 21609527 — Biomarker: MB mRNA
Type: Predictive Biomarker (PRD)
Genes: MB
Study 24911964 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 10500826 — Biomarker: BCR mRNA
Type: Predictive Biomarker (PRD)
Genes: BCR; BCR1; D22S11
Study 10500826 — Biomarker: Tyrosine-protein kinase ABL1
Type: Pharmacodynamic Biomarker (PDY)
Genes: ABL1; ABL; JTK7
Study 23570538 — Biomarker: SH2D1A mRNA
Type: Predictive Biomarker (PRD)
Genes: SH2D1A; DSHP; SAP
Study 9232210 — Biomarker: Homovanillic acid
Type: Pharmacodynamic Biomarker (PDY)
Study 9232210 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 3434164 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 19910076 — Biomarker: Granulocyte-macrophage colony-stimulating factor
Type: Safety Biomarker (SAF)
Genes: CSF2; GMCSF
Study 18403492 — Biomarker: Vascular endothelial growth factor
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY)
Study 11022366 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 9620526 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 25713659 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 19734132 — Biomarker: Bone mineral density
Type: Surrogate Endpoint (SUR)
Study 10319358 — Biomarker: C6orf15 mRNA
Type: Predictive Biomarker (PRD)
Genes: C6orf15; STG; UNQ1840/PRO3566
Study 8733039 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 28710205 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 1824760 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 29985223 — Biomarker: HHEX mRNA
Type: Predictive Biomarker (PRD)
Genes: HHEX; HEX; PRH; PRHX
Study 30552239 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 16419643 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 8877666 — Biomarker: Probing pocket depth
Type: Surrogate Endpoint (SUR)
Study 30873657 — Biomarker: PMM2 mRNA
Type: Predictive Biomarker (PRD)
Genes: PMM2
Study 25520340 — Biomarker: Bone mineral density
Type: Surrogate Endpoint (SUR)
Study 31743554 — Biomarker: INVS mRNA
Type: Predictive Biomarker (PRD)
Genes: INVS; INV; NPHP2
Study 31743554 — Biomarker: Lysosomal acid glucosylceramidase
Type: Pharmacodynamic Biomarker (PDY)
Genes: GBA1; GBA; GC; GLUC
Study 31743554 — Biomarker: AQP3 mRNA
Type: Predictive Biomarker (PRD)
Genes: AQP3
Study 31743554 — Biomarker: ELOVL3 mRNA
Type: Predictive Biomarker (PRD)
Genes: ELOVL3; CIG30
Study 23602291 — Biomarker: Free fatty acids
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY)
Study 19008718 — Biomarker: PPARA mRNA
Type: Predictive Biomarker (PRD)
Genes: PPARA; NR1C1; PPAR
Study 19008718 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 19008718 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 19008718 — Biomarker: High density lipoprotein cholesterol
Type: Pharmacodynamic Biomarker (PDY)
Study 19008718 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 19008718 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 12919430 — Biomarker: AMT mRNA
Type: Predictive Biomarker (PRD)
Genes: AMT; GCST
Study 12919430 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 9322471 — Biomarker: HR mRNA
Type: Predictive Biomarker (PRD)
Genes: HR
Study 8139175 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 8139175 — Biomarker: High density lipoprotein cholesterol
Type: Pharmacodynamic Biomarker (PDY)
Study 30856182 — Biomarker: Pulmonary vascular resistance
Type: Surrogate Endpoint (SUR)
Study 27228651 — Biomarker: COMP mRNA
Type: Predictive Biomarker (PRD)
Genes: COMP
Study 27228651 — Biomarker: Myeloperoxidase
Type: Safety Biomarker (SAF)
Genes: MPO
Study 27228651 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 25122648 — Biomarker: TG mRNA
Type: Predictive Biomarker (PRD)
Genes: TG
Study 21531577 — Biomarker: Pulmonary vascular resistance
Type: Surrogate Endpoint (SUR)
Study 15542572 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 2170852 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 22393084 — Biomarker: Erbb2 tyrosine kinase receptor
Type: Predictive Biomarker (PRD)
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 17936185 — Biomarker: Coagulation factor IIa
Type: Safety Biomarker (SAF)
Genes: F2
Study 15009332 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 9853647 — Biomarker: Valproic acid
Type: Pharmacodynamic Biomarker (PDY)
Study 22112605 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 17389554 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 11826641 — Biomarker: Interleukin 6
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: IL6; IFNB2
Study 17251482 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 9562938 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 7698127 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 7698127 — Biomarker: High density lipoprotein cholesterol
Type: Pharmacodynamic Biomarker (PDY)
Study 22465206 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 22013794 — Biomarker: TG mRNA
Type: Predictive Biomarker (PRD)
Genes: TG
Study 19079839 — Biomarker: MIP mRNA
Type: Predictive Biomarker (PRD)
Genes: MIP; AQP0
Study 19079839 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 16697324 — Biomarker: PAH mRNA
Type: Predictive Biomarker (PRD)
Genes: PAH
Study 16091234 — Biomarker: DSP mRNA
Type: Predictive Biomarker (PRD)
Genes: DSP
Study 11306776 — Biomarker: D-dimer
Type: Safety Biomarker (SAF); Monitoring Biomarker (MOI)
Study 2573325 — Biomarker: LBP mRNA
Type: Predictive Biomarker (PRD)
Genes: LBP
Study 2573325 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 239414 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 25361548 — Biomarker: Gamma-Histone H2AX
Type: Pharmacodynamic Biomarker (PDY)
Genes: H2AX; H2AFX
Study 19906002 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 19906002 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 19906002 — Biomarker: Interleukin 6
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: IL6; IFNB2
Study 21057560 — Biomarker: HMMR mRNA
Type: Predictive Biomarker (PRD)
Genes: HMMR; IHABP; RHAMM
Study 11676153 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 14628495 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 11140558 — Biomarker: Probing pocket depth
Type: Surrogate Endpoint (SUR)