AIM-Harvard/TrialPanorama-filtered huggingface dataset:
Study 11407868 — Biomarker: Serum albumin
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY)
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 7956628 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 26718578 — Biomarker: CD4 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD4
Study 26718578 — Biomarker: Interleukin 17
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY)
Genes: IL17A; CTLA8; IL17
Study 26035251 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 22412169 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 22412169 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 22412169 — Biomarker: Serum creatinine
Type: Surrogate Endpoint (SUR)
Study 22412169 — Biomarker: High density lipoprotein cholesterol
Type: Pharmacodynamic Biomarker (PDY)
Study 11943418 — Biomarker: Serum creatinine
Type: Surrogate Endpoint (SUR)
Study 10356104 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 1954814 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 27765365 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 27765365 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 27765365 — Biomarker: High density lipoprotein cholesterol
Type: Pharmacodynamic Biomarker (PDY)
Study 25563311 — Biomarker: Eosinophil cationic protein
Type: Safety Biomarker (SAF)
Genes: RNASE3; ECP; RNS3
Study 20477825 — Biomarker: Serum sodium
Type: Surrogate Endpoint (SUR)
Study 11908712 — Biomarker: EFS mRNA
Type: Predictive Biomarker (PRD)
Genes: EFS; CASS3
Study 23712056 — Biomarker: Metalloproteinase inhibitor 1
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: TIMP1; CLGI; TIMP
Study 11437028 — Biomarker: IK mRNA
Type: Predictive Biomarker (PRD)
Genes: IK; RED; RER
Study 30322392 — Biomarker: Free fatty acids
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY)
Study 11128879 — Biomarker: DDT mRNA
Type: Predictive Biomarker (PRD)
Genes: DDT
Study 3522159 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 3522159 — Biomarker: Serum potassium
Type: Surrogate Endpoint (SUR)
Study 25985726 — Biomarker: miR-200a
Type: Safety Biomarker (SAF)
Genes: MIR200A
Study 25985726 — Biomarker: miR-155
Type: Safety Biomarker (SAF)
Genes: MIR155
Study 23197844 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 21233091 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 17130328 — Biomarker: White blood cell
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Study 17130328 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 12480972 — Biomarker: Serum creatinine
Type: Surrogate Endpoint (SUR)
Study 1609038 — Biomarker: CCS mRNA
Type: Predictive Biomarker (PRD)
Genes: CCS
Study 1609038 — Biomarker: GAST mRNA
Type: Predictive Biomarker (PRD)
Genes: GAST; GAS
Study 30205315 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 15763286 — Biomarker: Eosinophil cationic protein
Type: Safety Biomarker (SAF)
Genes: RNASE3; ECP; RNS3
Study 15763286 — Biomarker: Immunoglobulin E
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Study 7772359 — Biomarker: HR mRNA
Type: Predictive Biomarker (PRD)
Genes: HR
Study 758627 — Biomarker: EP300 mRNA
Type: Predictive Biomarker (PRD)
Genes: EP300; P300
Study 27801415 — Biomarker: CD68 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD68
Study 27801415 — Biomarker: Metalloproteinase inhibitor 1
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: TIMP1; CLGI; TIMP
Study 3288258 — Biomarker: Serum calcium
Type: Surrogate Endpoint (SUR)
Study 3288258 — Biomarker: Serum phosphate
Type: Pharmacodynamic Biomarker (PDY)
Study 30184513 — Biomarker: VDR mRNA
Type: Predictive Biomarker (PRD)
Genes: VDR; NR1I1
Study 15127203 — Biomarker: PIK3CA
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: PI3K
Study 2104626 — Biomarker: TBXT mRNA
Type: Predictive Biomarker (PRD)
Genes: TBXT; T
Study 31880734 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 23497506 — Biomarker: TG mRNA
Type: Predictive Biomarker (PRD)
Genes: TG
Study 23497506 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 19124984 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 2643592 — Biomarker: STS mRNA
Type: Predictive Biomarker (PRD)
Genes: STS; ARSC1
Study 30911753 — Biomarker: CP mRNA
Type: Predictive Biomarker (PRD)
Genes: CP
Study 22379908 — Biomarker: MBP mRNA
Type: Predictive Biomarker (PRD)
Genes: MBP
Study 22379908 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 8252687 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 23137823 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 23137823 — Biomarker: Serum triglycerides
Type: Surrogate Endpoint (SUR)
Study 23137823 — Biomarker: Free fatty acids
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY)
Study 8385164 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 8385164 — Biomarker: High density lipoprotein cholesterol
Type: Pharmacodynamic Biomarker (PDY)
Study 2908819 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 31904707 — Biomarker: SFPQ mRNA
Type: Predictive Biomarker (PRD)
Genes: SFPQ; PSF
Study 1683818 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 7121808 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 10357377 — Biomarker: CD4 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD4
Study 7573097 — Biomarker: Hematologic response
Type: Surrogate Endpoint (SUR)
Study 12907329 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 10388649 — Biomarker: Neutralizing antibody
Type: Surrogate Endpoint (SUR)
Study 29397092 — Biomarker: High density lipoprotein cholesterol
Type: Pharmacodynamic Biomarker (PDY)
Study 29397092 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 18033323 — Biomarker: RAD51 mRNA
Type: Predictive Biomarker (PRD)
Genes: RAD51; RAD51A; RECA
Study 18033323 — Biomarker: XRCC3 mRNA
Type: Predictive Biomarker (PRD)
Genes: XRCC3
Study 18033323 — Biomarker: GSTM1 mRNA
Type: Predictive Biomarker (PRD)
Genes: GSTM1; GST1
Study 11828042 — Biomarker: FEV mRNA
Type: Predictive Biomarker (PRD)
Genes: FEV; PET1
Study 11828042 — Biomarker: HGS mRNA
Type: Predictive Biomarker (PRD)
Genes: HGS; HRS
Study 7731622 — Biomarker: CCK mRNA
Type: Predictive Biomarker (PRD)
Genes: CCK
Study 28567691 — Biomarker: PYCARD mRNA
Type: Predictive Biomarker (PRD)
Genes: PYCARD; ASC; CARD5; TMS1
Study 21676011 — Biomarker: TRPV1 mRNA
Type: Predictive Biomarker (PRD)
Genes: TRPV1; VR1
Study 19765496 — Biomarker: SCT mRNA
Type: Predictive Biomarker (PRD)
Genes: SCT
Study 11235719 — Biomarker: Superoxide dismutase Cu-Zn
Type: Pharmacodynamic Biomarker (PDY)
Genes: SOD1
Study 11235719 — Biomarker: Pulmonary vascular resistance
Type: Surrogate Endpoint (SUR)
Study 19788440 — Biomarker: White blood cell
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Study 19788440 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 19788440 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 19788440 — Biomarker: Interleukin 8
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: CXCL8; IL8
Study 10096582 — Biomarker: CD4 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD4
Study 30948335 — Biomarker: TP53
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: p53; LFS1
Study 25879572 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 25879572 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 21342376 — Biomarker: Serum testosterone
Type: Surrogate Endpoint (SUR)
Study 9577354 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 22104550 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 22104550 — Biomarker: High density lipoprotein cholesterol
Type: Pharmacodynamic Biomarker (PDY)
Study 22104550 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 16875929 — Biomarker: DCC mRNA
Type: Predictive Biomarker (PRD)
Genes: DCC; IGDCC1
Study 10720170 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 1548998 — Biomarker: CD4 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD4
Study 22009803 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 9038595 — Biomarker: Bone mineral density
Type: Surrogate Endpoint (SUR)
Study 2892874 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 30020987 — Biomarker: Adrenomedullin
Type: Safety Biomarker (SAF); Monitoring Biomarker (MOI)
Genes: ADM; AM
Study 24554962 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 22854639 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 9041328 — Biomarker: CD4 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD4
Study 27213613 — Biomarker: Immunoglobulin E
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Study 23692706 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 7526126 — Biomarker: von Willebrand factor
Type: Safety Biomarker (SAF)
Genes: VWF; F8VWF
Study 25117722 — Biomarker: RPE mRNA
Type: Predictive Biomarker (PRD)
Genes: RPE; HUSSY-17
Study 23172749 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 23172749 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 12953129 — Biomarker: Granulocyte-macrophage colony-stimulating factor
Type: Safety Biomarker (SAF)
Genes: CSF2; GMCSF
Study 18201827 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 16968874 — Biomarker: TP53
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: p53; LFS1
Study 9391998 — Biomarker: Bone mineral density
Type: Surrogate Endpoint (SUR)
Study 26427705 — Biomarker: Cytochrome P450 2C19
Type: Safety Biomarker (SAF)
Genes: CYP2C19
Study 24174910 — Biomarker: HR mRNA
Type: Predictive Biomarker (PRD)
Genes: HR
Study 21678045 — Biomarker: FEV mRNA
Type: Predictive Biomarker (PRD)
Genes: FEV; PET1
Study 18344635 — Biomarker: FEV mRNA
Type: Predictive Biomarker (PRD)
Genes: FEV; PET1
Study 12679447 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 10616235 — Biomarker: Forced vital capacity
Type: Surrogate Endpoint (SUR)
Study 2033429 — Biomarker: Granulocyte-macrophage colony-stimulating factor
Type: Safety Biomarker (SAF)
Genes: CSF2; GMCSF
Study 27744007 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 23639243 — Biomarker: CD4 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD4
Study 20884893 — Biomarker: Cervical intraepithelial neoplasia
Type: Surrogate Endpoint (SUR)
Study 16338010 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 10851665 — Biomarker: Superoxide dismutase Cu-Zn
Type: Pharmacodynamic Biomarker (PDY)
Genes: SOD1
Study 10851665 — Biomarker: Valproic acid
Type: Pharmacodynamic Biomarker (PDY)
Study 1917227 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 29471132 — Biomarker: Interleukin 1
Type: Safety Biomarker (SAF)
Study 29471132 — Biomarker: C-C motif chemokine 2
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CCL2; MCP1; SCYA2
Study 12461831 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 10624752 — Biomarker: TES mRNA
Type: Predictive Biomarker (PRD)
Genes: TES
Study 2109470 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 29432640 — Biomarker: Bacterial count
Type: Surrogate Endpoint (SUR)
Study 25467093 — Biomarker: HR mRNA
Type: Predictive Biomarker (PRD)
Genes: HR
Study 25467093 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 25765696 — Biomarker: Dipeptidyl peptidase 4
Type: Pharmacodynamic Biomarker (PDY)
Genes: DPP4; ADCP2; CD26
Study 27914492 — Biomarker: DES mRNA
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: DES
Study 25618415 — Biomarker: GEM mRNA
Type: Predictive Biomarker (PRD)
Genes: GEM; KIR
Study 25618415 — Biomarker: CAP1 mRNA
Type: Predictive Biomarker (PRD)
Genes: CAP1; CAP
Study 21943132 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 18301974 — Biomarker: Bone mineral density
Type: Surrogate Endpoint (SUR)
Study 29079990 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 29103871 — Biomarker: White blood cell
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Study 31888745 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 24975199 — Biomarker: MAL mRNA
Type: Predictive Biomarker (PRD)
Genes: MAL
Study 28102098 — Biomarker: CDKN1B mRNA
Type: Predictive Biomarker (PRD)
Genes: CDKN1B; KIP1; p27
Study 28102098 — Biomarker: Ki-67
Type: Predictive Biomarker (PRD)
Genes: MKI67; MIB-1; PPP1R105
Study 23545926 — Biomarker: Hyaluronic acid
Type: Safety Biomarker (SAF)
Study 18373141 — Biomarker: CDS1 mRNA
Type: Predictive Biomarker (PRD)
Genes: CDS1; CDS
Study 18373141 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 1530677 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 3968001 — Biomarker: Arginine vasopressin
Type: Predictive Biomarker (PRD)
Genes: AVP; ARVP; VP
Study 30796036 — Biomarker: Erbb2 tyrosine kinase receptor
Type: Predictive Biomarker (PRD)
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 30796036 — Biomarker: ERBB3 mRNA
Type: Predictive Biomarker (PRD)
Genes: ERBB3; HER3
Study 30796036 — Biomarker: Proto-oncogene c-Met
Type: Predictive Biomarker (PRD)
Genes: MET
Study 30796036 — Biomarker: Epidermal growth factor receptor
Type: Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: EGFR; ERBB; ERBB1; HER1
Study 30796036 — Biomarker: Phosphatase and tensin homolog
Type: Predictive Biomarker (PRD)
Genes: PTEN; MMAC1; TEP1
Study 30796036 — Biomarker: PIK3CA
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: PI3K
Study 15031340 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 9839657 — Biomarker: TF mRNA
Type: Predictive Biomarker (PRD)
Genes: TF; PRO1400
Study 9839657 — Biomarker: CD4 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD4
Study 27322814 — Biomarker: Endothelin-1
Type: Safety Biomarker (SAF); Monitoring Biomarker (MOI)
Genes: EDN1
Study 17033231 — Biomarker: CPA1 mRNA
Type: Predictive Biomarker (PRD)
Genes: CPA1; CPA
Study 17033231 — Biomarker: Adrenomedullin
Type: Safety Biomarker (SAF); Monitoring Biomarker (MOI)
Genes: ADM; AM
Study 12689404 — Biomarker: PVR mRNA
Type: Predictive Biomarker (PRD)
Genes: PVR; PVS
Study 1412183 — Biomarker: TAT mRNA
Type: Predictive Biomarker (PRD)
Genes: TAT
Study 1412183 — Biomarker: D-dimer
Type: Safety Biomarker (SAF); Monitoring Biomarker (MOI)
Study 25080537 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 23463680 — Biomarker: EMD mRNA
Type: Predictive Biomarker (PRD)
Genes: EMD; EDMD; STA
Study 2949169 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 22983778 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 18042473 — Biomarker: HR mRNA
Type: Predictive Biomarker (PRD)
Genes: HR
Study 31775403 — Biomarker: DMD
Type: Predictive Biomarker (PRD)
Genes: BMD; DXS142; DXS164; DXS206; DXS230; DXS239; DXS268; DXS269; DXS270; DXS272
Study 31775403 — Biomarker: Bone mineral density
Type: Surrogate Endpoint (SUR)
Study 15353978 — Biomarker: CD4 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD4
Study 21069379 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 19477353 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 27930383 — Biomarker: MB mRNA
Type: Predictive Biomarker (PRD)
Genes: MB
Study 24057202 — Biomarker: FBP1 mRNA
Type: Predictive Biomarker (PRD)
Genes: FBP1; FBP
Study 19794330 — Biomarker: HTR3A mRNA
Type: Predictive Biomarker (PRD)
Genes: HTR3A; 5HT3R; HTR3
Study 7924177 — Biomarker: Serum triglycerides
Type: Surrogate Endpoint (SUR)
Study 7924177 — Biomarker: Serum sodium
Type: Surrogate Endpoint (SUR)
Study 7924177 — Biomarker: Serum potassium
Type: Surrogate Endpoint (SUR)
Study 7924177 — Biomarker: Serum creatinine
Type: Surrogate Endpoint (SUR)
Study 7924177 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 22538532 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 11049908 — Biomarker: HR mRNA
Type: Predictive Biomarker (PRD)
Genes: HR
Study 11049908 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 30091061 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 30091061 — Biomarker: Serum albumin
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY)
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 30091061 — Biomarker: Serum creatinine
Type: Surrogate Endpoint (SUR)
Study 8595510 — Biomarker: CD4 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD4
Study 2651031 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 28847751 — Biomarker: SMAD7 mRNA
Type: Predictive Biomarker (PRD)
Genes: SMAD7; MADH7; MADH8
Study 27306435 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 27306435 — Biomarker: High density lipoprotein cholesterol
Type: Pharmacodynamic Biomarker (PDY)
Study 27306435 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 24769270 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 18404609 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 18404609 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 16162741 — Biomarker: CD55 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD55; CR; DAF
Study 9259823 — Biomarker: Lactate dehydrogenase
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Study 10090111 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 31663620 — Biomarker: ACAT1 mRNA
Type: Predictive Biomarker (PRD)
Genes: ACAT1; ACAT; MAT
Study 25591799 — Biomarker: Vascular endothelial growth factor A
Type: Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: VEGFA; VEGF
Study 25591799 — Biomarker: Vascular endothelial growth factor
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY)
Study 25618969 — Biomarker: CAT mRNA
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: CAT
Study 25618969 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 25618969 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 25618969 — Biomarker: Forced vital capacity
Type: Surrogate Endpoint (SUR)
Study 25618969 — Biomarker: Reactive oxygen species
Type: Safety Biomarker (SAF)
Study 25618969 — Biomarker: Superoxide dismutase Cu-Zn
Type: Pharmacodynamic Biomarker (PDY)
Genes: SOD1
Study 25618969 — Biomarker: IL4
Type: Safety Biomarker (SAF)
Genes: BSF1; IL-4; BCGF1; BCGF-1; MGC79402
Study 20888887 — Biomarker: 5HTT
Type: Predictive Biomarker (PRD)
Genes: SLC6A4; 5-HTT; SERT1
Study 20888887 — Biomarker: SLC6A4 mRNA
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: SLC6A4; HTT; SERT
Study 2097908 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 16356228 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 16356228 — Biomarker: IL-6 and IL-10
Type: Safety Biomarker (SAF)
Study 12421159 — Biomarker: VIP mRNA
Type: Predictive Biomarker (PRD)
Genes: VIP
Study 12421159 — Biomarker: NPY mRNA
Type: Predictive Biomarker (PRD)
Genes: NPY
Study 29358012 — Biomarker: Cytochrome P450 2D6
Type: Safety Biomarker (SAF)
Genes: CYP2D6; CYP2DL1
Study 15897788 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 15897788 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 15897788 — Biomarker: High density lipoprotein cholesterol
Type: Pharmacodynamic Biomarker (PDY)
Study 19857446 — Biomarker: CD4 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD4
Study 19857446 — Biomarker: Neutralizing antibody
Type: Surrogate Endpoint (SUR)
Study 15579914 — Biomarker: SHBG mRNA
Type: Predictive Biomarker (PRD)
Genes: SHBG
Study 15579914 — Biomarker: SERPINA6 mRNA
Type: Predictive Biomarker (PRD)
Genes: SERPINA6; CBG
Study 31067329 — Biomarker: Bone mineral density
Type: Surrogate Endpoint (SUR)
Study 21946824 — Biomarker: Reactive oxygen species
Type: Safety Biomarker (SAF)
Study 12032174 — Biomarker: LPL mRNA
Type: Predictive Biomarker (PRD)
Genes: LPL; LIPD
Study 12032174 — Biomarker: Apolipoprotein E
Type: Predictive Biomarker (PRD)
Genes: APOE
Study 10090350 — Biomarker: Natriuretic peptides A
Type: Safety Biomarker (SAF)
Genes: NPPA; ANP; PND
Study 26673130 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 23019945 — Biomarker: TG mRNA
Type: Predictive Biomarker (PRD)
Genes: TG
Study 23019945 — Biomarker: High density lipoprotein cholesterol
Type: Pharmacodynamic Biomarker (PDY)
Study 23019945 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 7769306 — Biomarker: CD4 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD4
Study 2284577 — Biomarker: Serum creatinine
Type: Surrogate Endpoint (SUR)
Study 28522317 — Biomarker: CYP3A4 mRNA
Type: Predictive Biomarker (PRD)
Genes: CYP3A4; CYP3A3
Study 28522317 — Biomarker: CYP3A5 mRNA
Type: Predictive Biomarker (PRD)
Genes: CYP3A5
Study 23601741 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 17307303 — Biomarker: CDS1 mRNA
Type: Predictive Biomarker (PRD)
Genes: CDS1; CDS
Study 17307303 — Biomarker: Exhaled carbon monoxide
Type: Surrogate Endpoint (SUR)
Study 30595567 — Biomarker: miR-21
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: MIR21
Study 8829162 — Biomarker: Glutamate carboxypeptidase II
Type: Predictive Biomarker (PRD)
Genes: FOLH1; FOLH; NAALAD1; PSM; PSMA; GIG27
Study 8101024 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 2946838 — Biomarker: Natriuretic peptides A
Type: Safety Biomarker (SAF)
Genes: NPPA; ANP; PND
Study 2946838 — Biomarker: Serum sodium
Type: Surrogate Endpoint (SUR)
Study 24013058 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 17472022 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 12829659 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2