AIM-Harvard/TrialPanorama-filtered huggingface dataset:
Study 14767877 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 14767877 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 7656832 — Biomarker: CD4 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD4
Study 19539180 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 19539180 — Biomarker: High density lipoprotein cholesterol
Type: Pharmacodynamic Biomarker (PDY)
Study 9480236 — Biomarker: Beta-2-microglobulin
Type: Safety Biomarker (SAF)
Genes: B2M; CDABP0092; HDCMA22P
Study 946973 — Biomarker: Neutralizing antibody
Type: Surrogate Endpoint (SUR)
Study 30811775 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 24054187 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 29716702 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 22493422 — Biomarker: Vascular endothelial growth factor
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY)
Study 19087296 — Biomarker: Hyaluronic acid
Type: Safety Biomarker (SAF)
Study 30507731 — Biomarker: HR mRNA
Type: Predictive Biomarker (PRD)
Genes: HR
Study 30507731 — Biomarker: RPE mRNA
Type: Predictive Biomarker (PRD)
Genes: RPE; HUSSY-17
Study 28231831 — Biomarker: SLC5A2 mRNA
Type: Predictive Biomarker (PRD)
Genes: SLC5A2; SGLT2
Study 28231831 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 9730996 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 23021205 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 15309392 — Biomarker: CAT mRNA
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: CAT
Study 15309392 — Biomarker: Superoxide dismutase Cu-Zn
Type: Pharmacodynamic Biomarker (PDY)
Genes: SOD1
Study 23916488 — Biomarker: AMD1 mRNA
Type: Predictive Biomarker (PRD)
Genes: AMD1; AMD
Study 8872973 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 10193874 — Biomarker: HP mRNA
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: HP
Study 30871514 — Biomarker: TG mRNA
Type: Predictive Biomarker (PRD)
Genes: TG
Study 30871514 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 30871514 — Biomarker: High density lipoprotein cholesterol
Type: Pharmacodynamic Biomarker (PDY)
Study 28986058 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 26404640 — Biomarker: NNT mRNA
Type: Predictive Biomarker (PRD)
Genes: NNT
Study 23084675 — Biomarker: ISM1 mRNA
Type: Predictive Biomarker (PRD)
Genes: ISM1; C20orf82; ISM
Study 19934131 — Biomarker: MB mRNA
Type: Predictive Biomarker (PRD)
Genes: MB
Study 2172280 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 2172280 — Biomarker: White blood cell
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Study 31858673 — Biomarker: Dipeptidyl peptidase 4
Type: Pharmacodynamic Biomarker (PDY)
Genes: DPP4; ADCP2; CD26
Study 30741744 — Biomarker: PCSK9 mRNA
Type: Predictive Biomarker (PRD)
Genes: PCSK9; NARC1; PSEC0052
Study 30741744 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 30741744 — Biomarker: High density lipoprotein cholesterol
Type: Pharmacodynamic Biomarker (PDY)
Study 26864362 — Biomarker: GSS mRNA
Type: Predictive Biomarker (PRD)
Genes: GSS
Study 26864362 — Biomarker: HP mRNA
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: HP
Study 30169657 — Biomarker: CALD1 mRNA
Type: Predictive Biomarker (PRD)
Genes: CALD1; CAD; CDM
Study 30169657 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 24282872 — Biomarker: Bacterial count
Type: Surrogate Endpoint (SUR)
Study 26632893 — Biomarker: Cytochrome P450 2C19
Type: Safety Biomarker (SAF)
Genes: CYP2C19
Study 8983091 — Biomarker: CCK mRNA
Type: Predictive Biomarker (PRD)
Genes: CCK
Study 24598244 — Biomarker: GAD2 mRNA
Type: Predictive Biomarker (PRD)
Genes: GAD2; GAD65
Study 20564242 — Biomarker: Bone mineral density
Type: Surrogate Endpoint (SUR)
Study 15129394 — Biomarker: Bone mineral density
Type: Surrogate Endpoint (SUR)
Study 27592112 — Biomarker: BIRC5 mRNA
Type: Predictive Biomarker (PRD)
Genes: BIRC5; API4; IAP4
Study 27592112 — Biomarker: TFF1 mRNA
Type: Predictive Biomarker (PRD)
Genes: TFF1; BCEI; PS2
Study 27592112 — Biomarker: MYBL2 mRNA
Type: Predictive Biomarker (PRD)
Genes: MYBL2; BMYB
Study 27592112 — Biomarker: CCNB1 mRNA
Type: Predictive Biomarker (PRD)
Genes: CCNB1; CCNB
Study 16297750 — Biomarker: BAG3 mRNA
Type: Predictive Biomarker (PRD)
Genes: BAG3; BIS
Study 16297750 — Biomarker: CPB1 mRNA
Type: Predictive Biomarker (PRD)
Genes: CPB1; CPB; PCPB
Study 10816746 — Biomarker: SI mRNA
Type: Predictive Biomarker (PRD)
Genes: SI
Study 8574280 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 540445 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 29948221 — Biomarker: CD44 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD44; LHR; MDU2; MDU3; MIC4
Study 29948221 — Biomarker: ITPR1 mRNA
Type: Predictive Biomarker (PRD)
Genes: ITPR1; INSP3R1
Study 29948221 — Biomarker: MTSS1 mRNA
Type: Predictive Biomarker (PRD)
Genes: MTSS1; KIAA0429; MIM
Study 22829944 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 22829944 — Biomarker: High density lipoprotein cholesterol
Type: Pharmacodynamic Biomarker (PDY)
Study 22829944 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 12499479 — Biomarker: FXYD1 mRNA
Type: Predictive Biomarker (PRD)
Genes: FXYD1; PLM
Study 25467012 — Biomarker: HAL mRNA
Type: Predictive Biomarker (PRD)
Genes: HAL; HIS
Study 25467012 — Biomarker: Cervical intraepithelial neoplasia
Type: Surrogate Endpoint (SUR)
Study 30476490 — Biomarker: CCK mRNA
Type: Predictive Biomarker (PRD)
Genes: CCK
Study 27465384 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 27465384 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 20802250 — Biomarker: EPX mRNA
Type: Predictive Biomarker (PRD)
Genes: EPX; EPER; EPO; EPP
Study 18852398 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 18852398 — Biomarker: High density lipoprotein cholesterol
Type: Pharmacodynamic Biomarker (PDY)
Study 18852398 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 12064336 — Biomarker: Bone mineral density
Type: Surrogate Endpoint (SUR)
Study 12064336 — Biomarker: Intact parathyroid hormone
Type: Predictive Biomarker (PRD)
Study 30674601 — Biomarker: DMD mRNA
Type: Predictive Biomarker (PRD)
Genes: DMD
Study 28624898 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 17516022 — Biomarker: ASRGL1 mRNA
Type: Predictive Biomarker (PRD)
Genes: ASRGL1; ALP; CRASH
Study 12886697 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 8160096 — Biomarker: Lactate dehydrogenase
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Study 18245546 — Biomarker: CLU mRNA
Type: Predictive Biomarker (PRD)
Genes: CLU; APOJ; CLI; KUB1; AAG4
Study 16989201 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 16989201 — Biomarker: Interferon gamma
Type: Safety Biomarker (SAF); Monitoring Biomarker (MOI)
Genes: IFNG
Study 12975739 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 1679961 — Biomarker: GGT1 mRNA
Type: Predictive Biomarker (PRD)
Genes: GGT1; GGT
Study 3083741 — Biomarker: FEV mRNA
Type: Predictive Biomarker (PRD)
Genes: FEV; PET1
Study 3083741 — Biomarker: HR mRNA
Type: Predictive Biomarker (PRD)
Genes: HR
Study 3083741 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 29471812 — Biomarker: Serum triglycerides
Type: Surrogate Endpoint (SUR)
Study 20942667 — Biomarker: CD4 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD4
Study 8660020 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 20522572 — Biomarker: IK mRNA
Type: Predictive Biomarker (PRD)
Genes: IK; RED; RER
Study 2542682 — Biomarker: POMC
Type: Predictive Biomarker (PRD)
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 26404895 — Biomarker: LBP mRNA
Type: Predictive Biomarker (PRD)
Genes: LBP
Study 17463304 — Biomarker: NCAM1 mRNA
Type: Predictive Biomarker (PRD)
Genes: NCAM1; NCAM
Study 2951051 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 23994382 — Biomarker: HBV DNA
Type: Monitoring Biomarker (MOI)
Study 22743137 — Biomarker: HP mRNA
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: HP
Study 20845002 — Biomarker: LOX mRNA
Type: Predictive Biomarker (PRD)
Genes: LOX
Study 16630151 — Biomarker: Interleukin 10
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: IL10
Study 10618542 — Biomarker: Neutralizing antibody
Type: Surrogate Endpoint (SUR)
Study 19384263 — Biomarker: Serum bactericidal antibody
Type: Surrogate Endpoint (SUR)
Study 12081584 — Biomarker: Intact parathyroid hormone
Type: Predictive Biomarker (PRD)
Study 12081584 — Biomarker: Serum calcium
Type: Surrogate Endpoint (SUR)
Study 3265347 — Biomarker: Interleukin 2
Type: Safety Biomarker (SAF)
Genes: IL2
Study 25764956 — Biomarker: NF2 mRNA
Type: Predictive Biomarker (PRD)
Genes: NF2; SCH
Study 16299352 — Biomarker: LCT mRNA
Type: Predictive Biomarker (PRD)
Genes: LCT; LPH
Study 16299352 — Biomarker: TG mRNA
Type: Predictive Biomarker (PRD)
Genes: TG
Study 1627419 — Biomarker: Estrogen receptor
Type: Predictive Biomarker (PRD)
Genes: ESR1; ESR; NR3A1
Study 16361166 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 10641952 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 7772614 — Biomarker: POMC
Type: Predictive Biomarker (PRD)
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 31865631 — Biomarker: CAT mRNA
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: CAT
Study 30981585 — Biomarker: FGA mRNA
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: FGA
Study 28834469 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 25689936 — Biomarker: Serum albumin
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY)
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 18794865 — Biomarker: Granulocyte-macrophage colony-stimulating factor
Type: Safety Biomarker (SAF)
Genes: CSF2; GMCSF
Study 18794865 — Biomarker: CD34 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD34
Study 15207943 — Biomarker: CCK mRNA
Type: Predictive Biomarker (PRD)
Genes: CCK
Study 19841149 — Biomarker: AR mRNA
Type: Predictive Biomarker (PRD)
Genes: AR; DHTR; NR3C4
Study 28109962 — Biomarker: Vascular endothelial growth factor A
Type: Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: VEGFA; VEGF
Study 28109962 — Biomarker: von Willebrand factor
Type: Safety Biomarker (SAF)
Genes: VWF; F8VWF
Study 28109962 — Biomarker: Vascular endothelial growth factor
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY)
Study 28109962 — Biomarker: Angiopoietin-2
Type: Safety Biomarker (SAF); Monitoring Biomarker (MOI)
Genes: ANGPT2
Study 21528627 — Biomarker: Bone mineral density
Type: Surrogate Endpoint (SUR)
Study 16062032 — Biomarker: Pulmonary vascular resistance
Type: Surrogate Endpoint (SUR)
Study 11783255 — Biomarker: Superoxide dismutase Cu-Zn
Type: Pharmacodynamic Biomarker (PDY)
Genes: SOD1
Study 8721897 — Biomarker: CD4 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD4
Study 2551560 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 2551560 — Biomarker: Cyclic guanosine monophosphate
Type: Pharmacodynamic Biomarker (PDY)
Study 31693083 — Biomarker: CAPS mRNA
Type: Predictive Biomarker (PRD)
Genes: CAPS
Study 30377198 — Biomarker: Indoleamine 2,3-dioxygenase 1
Type: Predictive Biomarker (PRD)
Genes: IDO1; IDO; INDO
Study 30377198 — Biomarker: Programmed cell death 1 ligand 1
Type: Predictive Biomarker (PRD)
Genes: CD274; B7H1; PDCD1L1; PDCD1LG1; PDL1
Study 19738090 — Biomarker: Procalcitonin
Type: Monitoring Biomarker (MOI)
Study 11552664 — Biomarker: Beta-2-microglobulin
Type: Safety Biomarker (SAF)
Genes: B2M; CDABP0092; HDCMA22P
Study 11552664 — Biomarker: Intercellular adhesion molecule 1
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: ICAM1
Study 2971549 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 24929949 — Biomarker: CYP1A2 mRNA
Type: Predictive Biomarker (PRD)
Genes: CYP1A2
Study 24929949 — Biomarker: SLC35A2 mRNA
Type: Predictive Biomarker (PRD)
Genes: SLC35A2; UGALT; UGT; UGTL
Study 22292421 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 22292421 — Biomarker: Interleukin 6
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: IL6; IFNB2
Study 10456490 — Biomarker: CYP3A4 mRNA
Type: Predictive Biomarker (PRD)
Genes: CYP3A4; CYP3A3
Study 31109746 — Biomarker: Interleukin 6
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: IL6; IFNB2
Study 22418908 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 22418908 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 22145774 — Biomarker: TEF mRNA
Type: Predictive Biomarker (PRD)
Genes: TEF; KIAA1655
Study 11520994 — Biomarker: OMD mRNA
Type: Predictive Biomarker (PRD)
Genes: OMD; SLRR2C; UNQ190/PRO216
Study 29220524 — Biomarker: LPP mRNA
Type: Predictive Biomarker (PRD)
Genes: LPP
Study 17205304 — Biomarker: Multidrug resistance protein 1
Type: Predictive Biomarker (PRD)
Genes: ABCB1; MDR1; PGY1
Study 9832300 — Biomarker: PPARA mRNA
Type: Predictive Biomarker (PRD)
Genes: PPARA; NR1C1; PPAR
Study 2693440 — Biomarker: Serum triglycerides
Type: Surrogate Endpoint (SUR)
Study 324487 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 21204963 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 10681072 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 9501335 — Biomarker: FHL5 mRNA
Type: Predictive Biomarker (PRD)
Genes: FHL5; ACT
Study 30024627 — Biomarker: CD4 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD4
Study 21632213 — Biomarker: Valproic acid
Type: Pharmacodynamic Biomarker (PDY)
Study 8930174 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 27491778 — Biomarker: Serine/threonine-protein kinase STK11
Type: Safety Biomarker (SAF)
Genes: STK11
Study 27491778 — Biomarker: 5'-AMP-activated protein kinase subunit beta-1
Type: Pharmacodynamic Biomarker (PDY)
Genes: PRKAB1; AMPK
Study 24445732 — Biomarker: Bone mineral density
Type: Surrogate Endpoint (SUR)
Study 18427285 — Biomarker: Free fatty acids
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY)
Study 16751039 — Biomarker: Neurofilament light polypeptide
Type: Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: NEFL; NF68; NFL
Study 7578986 — Biomarker: Granulocyte-macrophage colony-stimulating factor
Type: Safety Biomarker (SAF)
Genes: CSF2; GMCSF
Study 25413567 — Biomarker: TAT mRNA
Type: Predictive Biomarker (PRD)
Genes: TAT
Study 15319567 — Biomarker: Estrogen receptor
Type: Predictive Biomarker (PRD)
Genes: ESR1; ESR; NR3A1
Study 7123498 — Biomarker: White blood cell
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Study 25921035 — Biomarker: SST mRNA
Type: Predictive Biomarker (PRD)
Genes: SST
Study 22480204 — Biomarker: PTGS1 mRNA
Type: Predictive Biomarker (PRD)
Genes: PTGS1; COX1
Study 22480204 — Biomarker: LOX mRNA
Type: Predictive Biomarker (PRD)
Genes: LOX
Study 22480204 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 24944140 — Biomarker: Matrix metalloproteinase 1
Type: Monitoring Biomarker (MOI)
Genes: MMP1; CLG
Study 24944140 — Biomarker: Metalloproteinase inhibitor 1
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: TIMP1; CLGI; TIMP
Study 31369406 — Biomarker: Vascular endothelial growth factor
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY)
Study 28131632 — Biomarker: CD4 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD4
Study 28131632 — Biomarker: GEM mRNA
Type: Predictive Biomarker (PRD)
Genes: GEM; KIR
Study 28131632 — Biomarker: KLRC1 mRNA
Type: Predictive Biomarker (PRD)
Genes: KLRC1; NKG2A
Study 3069752 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 17310818 — Biomarker: CD4 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD4
Study 30670043 — Biomarker: Exhaled carbon monoxide
Type: Surrogate Endpoint (SUR)
Study 8551493 — Biomarker: Antithrombin-III
Type: Safety Biomarker (SAF)
Genes: SERPINC1; AT3; PRO0309
Study 29017497 — Biomarker: Dipeptidyl peptidase 4
Type: Pharmacodynamic Biomarker (PDY)
Genes: DPP4; ADCP2; CD26
Study 21910074 — Biomarker: Osteopontin
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: SPP1; BNSP; OPN; PSEC0156
Study 31018614 — Biomarker: Bone mineral density
Type: Surrogate Endpoint (SUR)
Study 6621025 — Biomarker: TBXT mRNA
Type: Predictive Biomarker (PRD)
Genes: TBXT; T
Study 6621025 — Biomarker: Carcinoembryonic antigen CEA
Type: Monitoring Biomarker (MOI)
Genes: CEACAM5; CEA
Study 26806045 — Biomarker: Plasma sitosterol and campesterol
Type: Surrogate Endpoint (SUR)
Study 16219105 — Biomarker: Epidermal growth factor receptor
Type: Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: EGFR; ERBB; ERBB1; HER1
Study 7318340 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 15105178 — Biomarker: Estrogen receptor
Type: Predictive Biomarker (PRD)
Genes: ESR1; ESR; NR3A1
Study 2642538 — Biomarker: TOX mRNA
Type: Predictive Biomarker (PRD)
Genes: TOX; KIAA0808
Study 2642538 — Biomarker: REL mRNA
Type: Predictive Biomarker (PRD)
Genes: REL
Study 31838199 — Biomarker: SCD mRNA
Type: Predictive Biomarker (PRD)
Genes: SCD; FADS5; SCD1; SCDOS
Study 25514103 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 25514103 — Biomarker: PON1 mRNA
Type: Predictive Biomarker (PRD)
Genes: PON1; PON
Study 25514103 — Biomarker: C-C motif chemokine 2
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CCL2; MCP1; SCYA2
Study 21660077 — Biomarker: PPARA mRNA
Type: Predictive Biomarker (PRD)
Genes: PPARA; NR1C1; PPAR
Study 9626918 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 29526019 — Biomarker: SLN mRNA
Type: Predictive Biomarker (PRD)
Genes: SLN
Study 22538329 — Biomarker: High density lipoprotein cholesterol
Type: Pharmacodynamic Biomarker (PDY)
Study 22538329 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 22538329 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 30880285 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 25806862 — Biomarker: Serum creatinine
Type: Surrogate Endpoint (SUR)
Study 17299107 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 29737494 — Biomarker: ADIPOQ mRNA
Type: Predictive Biomarker (PRD)
Genes: ADIPOQ; ACDC; ACRP30; APM1; GBP28
Study 29737494 — Biomarker: JAK1 mRNA
Type: Predictive Biomarker (PRD)
Genes: JAK1; JAK1A; JAK1B
Study 29737494 — Biomarker: JAK2 mRNA
Type: Predictive Biomarker (PRD)
Genes: JAK2
Study 29737494 — Biomarker: LEP mRNA
Type: Predictive Biomarker (PRD)
Genes: LEP; OB; OBS
Study 29737494 — Biomarker: IL6ST mRNA
Type: Predictive Biomarker (PRD)
Genes: IL6ST
Study 29737494 — Biomarker: Signal transducer and activator of transcription 3
Type: Pharmacodynamic Biomarker (PDY)
Genes: STAT3; APRF
Study 29737494 — Biomarker: MIF mRNA
Type: Predictive Biomarker (PRD)
Genes: MIF; GLIF; MMIF
Study 29737494 — Biomarker: C-C motif chemokine 2
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CCL2; MCP1; SCYA2
Study 29737494 — Biomarker: Matrix metalloproteinase 9
Type: Pharmacodynamic Biomarker (PDY)
Genes: MMP9; CLG4B
Study 29737494 — Biomarker: Interleukin 18
Type: Safety Biomarker (SAF)
Genes: IL18; IGIF; IL1F4
Study 29737494 — Biomarker: Interleukin 6 receptor alpha
Type: Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY)
Genes: IL6R
Study 21435141 — Biomarker: SLC5A2 mRNA
Type: Predictive Biomarker (PRD)
Genes: SLC5A2; SGLT2
Study 8440094 — Biomarker: Serum LDL cholesterol
Type: Surrogate Endpoint (SUR)
Study 3527514 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 3527514 — Biomarker: Serum potassium
Type: Surrogate Endpoint (SUR)
Study 3527514 — Biomarker: Serum uric acid
Type: Surrogate Endpoint (SUR)
Study 25502581 — Biomarker: PIK3CA
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: PI3K
Study 25502581 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 25502581 — Biomarker: Insulin receptor substrate 1
Type: Pharmacodynamic Biomarker (PDY)
Genes: IRS1
Study 18268422 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 1417231 — Biomarker: Complement C3
Type: Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: C3; CPAMD1
Study 1417231 — Biomarker: Complement C5
Type: Pharmacodynamic Biomarker (PDY)
Genes: C5; CPAMD4
Study 30429144 — Biomarker: GAST mRNA
Type: Predictive Biomarker (PRD)
Genes: GAST; GAS
Study 12501741 — Biomarker: Aminopeptidase N
Type: Safety Biomarker (SAF)
Genes: ANPEP; APN; CD13; PEPN
Study 3131041 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 8784319 — Biomarker: Thyroid stimulating hormone
Type: Safety Biomarker (SAF)
Study 28829934 — Biomarker: POU1F1 mRNA
Type: Predictive Biomarker (PRD)
Genes: POU1F1; GHF1; PIT1
Study 28829934 — Biomarker: CFH mRNA
Type: Predictive Biomarker (PRD)
Genes: CFH; HF; HF1; HF2
Study 25742472 — Biomarker: PIK3CA mRNA
Type: Predictive Biomarker (PRD)
Genes: PIK3CA
Study 25742472 — Biomarker: KRAS mRNA
Type: Predictive Biomarker (PRD)
Genes: KRAS; KRAS2; RASK2
Study 25742472 — Biomarker: NRAS mRNA
Type: Predictive Biomarker (PRD)
Genes: NRAS; HRAS1
Study 19552227 — Biomarker: EDA mRNA
Type: Predictive Biomarker (PRD)
Genes: EDA; ED1; EDA2
Study 17343309 — Biomarker: CD68 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD68
Study 11295651 — Biomarker: CAMP mRNA
Type: Predictive Biomarker (PRD)
Genes: CAMP; CAP18; FALL39; HSD26
Study 9560064 — Biomarker: HR mRNA
Type: Predictive Biomarker (PRD)
Genes: HR
Study 9560064 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 30614275 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 9648990 — Biomarker: Vascular endothelial growth factor A
Type: Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: VEGFA; VEGF
Study 9648990 — Biomarker: Vascular endothelial growth factor
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY)