AIM-Harvard/TrialPanorama-filtered huggingface dataset:
Study 30707661 — Biomarker: Aurora kinase A
Type: Predictive Biomarker (PRD)
Genes: AURKA; AIK; AIRK1; ARK1; AURA; AYK1; BTAK; IAK1; STK15; STK6
Study 10595868 — Biomarker: CD4 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD4
Study 8706777 — Biomarker: Cytochrome P450 2D6
Type: Safety Biomarker (SAF)
Genes: CYP2D6; CYP2DL1
Study 26843120 — Biomarker: PLA2G1B mRNA
Type: Predictive Biomarker (PRD)
Genes: PLA2G1B; PLA2; PLA2A; PPLA2
Study 26843120 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 25259743 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 20067641 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 10414756 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 7594425 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 31292457 — Biomarker: Cholesteryl ester transfer protein
Type: Pharmacodynamic Biomarker (PDY)
Genes: CETP
Study 29977328 — Biomarker: APC mRNA
Type: Predictive Biomarker (PRD)
Genes: APC; DP2.5
Study 29977328 — Biomarker: IL-6 and IL-10
Type: Safety Biomarker (SAF)
Study 29977328 — Biomarker: Mitochondrial DNA
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY)
Study 27960614 — Biomarker: NOS2 mRNA
Type: Predictive Biomarker (PRD)
Genes: NOS2; NOS2A
Study 7988180 — Biomarker: Serum potassium
Type: Surrogate Endpoint (SUR)
Study 3054048 — Biomarker: Probing pocket depth
Type: Surrogate Endpoint (SUR)
Study 21274882 — Biomarker: REG3A mRNA
Type: Predictive Biomarker (PRD)
Genes: REG3A; HIP; PAP; PAP1
Study 21274882 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 21274882 — Biomarker: Reactive oxygen species
Type: Safety Biomarker (SAF)
Study 29603684 — Biomarker: High density lipoprotein cholesterol
Type: Pharmacodynamic Biomarker (PDY)
Study 29603684 — Biomarker: Free fatty acids
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY)
Study 11171788 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 27974307 — Biomarker: HGS mRNA
Type: Predictive Biomarker (PRD)
Genes: HGS; HRS
Study 29194765 — Biomarker: KIT mRNA
Type: Predictive Biomarker (PRD)
Genes: KIT; SCFR
Study 27559981 — Biomarker: SP6 mRNA
Type: Predictive Biomarker (PRD)
Genes: SP6; KLF14
Study 15824212 — Biomarker: TF mRNA
Type: Predictive Biomarker (PRD)
Genes: TF; PRO1400
Study 15824212 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 8029260 — Biomarker: IGFALS mRNA
Type: Predictive Biomarker (PRD)
Genes: IGFALS; ALS
Study 23459753 — Biomarker: SLC38A2 mRNA
Type: Predictive Biomarker (PRD)
Genes: SLC38A2; ATA2; KIAA1382; SAT2; SNAT2
Study 17123204 — Biomarker: BBC3 mRNA
Type: Predictive Biomarker (PRD)
Genes: BBC3; PUMA
Study 12827582 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 9373227 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 15983677 — Biomarker: KCNN1 mRNA
Type: Predictive Biomarker (PRD)
Genes: KCNN1; SK
Study 22116464 — Biomarker: Erbb2 tyrosine kinase receptor
Type: Predictive Biomarker (PRD)
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 11592727 — Biomarker: Plasminogen activator inhibitor
Type: Safety Biomarker (SAF)
Genes: SERPINE1; PAI1; PLANH1
Study 9481526 — Biomarker: High density lipoprotein cholesterol
Type: Pharmacodynamic Biomarker (PDY)
Study 22796405 — Biomarker: OSCAR mRNA
Type: Predictive Biomarker (PRD)
Genes: OSCAR
Study 7636755 — Biomarker: PBX1 mRNA
Type: Predictive Biomarker (PRD)
Genes: PBX1; PRL
Study 81361 — Biomarker: Free fatty acids
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY)
Study 31004128 — Biomarker: WWTR1 mRNA
Type: Predictive Biomarker (PRD)
Genes: WWTR1; TAZ
Study 10396705 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 2103060 — Biomarker: DAP mRNA
Type: Predictive Biomarker (PRD)
Genes: DAP; DAP1
Study 2103060 — Biomarker: HR mRNA
Type: Predictive Biomarker (PRD)
Genes: HR
Study 15848482 — Biomarker: Serum creatinine
Type: Surrogate Endpoint (SUR)
Study 12070058 — Biomarker: CD68 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD68
Study 12070058 — Biomarker: CD4 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD4
Study 30222235 — Biomarker: BRCA1 mRNA
Type: Predictive Biomarker (PRD)
Genes: BRCA1; RNF53
Study 31725655 — Biomarker: GFAP mRNA
Type: Predictive Biomarker (PRD)
Genes: GFAP
Study 17405586 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 7572012 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 2144295 — Biomarker: SHBG mRNA
Type: Predictive Biomarker (PRD)
Genes: SHBG
Study 2144295 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 2144295 — Biomarker: Glucose-6-phosphate dehydrogenase
Type: Safety Biomarker (SAF)
Genes: G6PD
Study 31120908 — Biomarker: High density lipoprotein cholesterol
Type: Pharmacodynamic Biomarker (PDY)
Study 31120908 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 31120908 — Biomarker: Mitochondrial DNA
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY)
Study 27837439 — Biomarker: Serum sodium
Type: Surrogate Endpoint (SUR)
Study 25613307 — Biomarker: Carcinoembryonic antigen CEA
Type: Monitoring Biomarker (MOI)
Genes: CEACAM5; CEA
Study 30920571 — Biomarker: NPC1L1 mRNA
Type: Predictive Biomarker (PRD)
Genes: NPC1L1
Study 8226485 — Biomarker: Free fatty acids
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY)
Study 28406860 — Biomarker: Vascular endothelial growth factor
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY)
Study 26946952 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 23540683 — Biomarker: SCD mRNA
Type: Predictive Biomarker (PRD)
Genes: SCD; FADS5; SCD1; SCDOS
Study 7893268 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 12393276 — Biomarker: BCR mRNA
Type: Predictive Biomarker (PRD)
Genes: BCR; BCR1; D22S11
Study 12393276 — Biomarker: Tyrosine-protein kinase ABL1
Type: Pharmacodynamic Biomarker (PDY)
Genes: ABL1; ABL; JTK7
Study 23396142 — Biomarker: LIFR mRNA
Type: Predictive Biomarker (PRD)
Genes: LIFR
Study 23396142 — Biomarker: miR-140
Type: Safety Biomarker (SAF)
Genes: MIR140
Study 23396142 — Biomarker: miR-142
Type: Safety Biomarker (SAF)
Genes: MIR142
Study 23396142 — Biomarker: miR-125b
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Study 23396142 — Biomarker: miR-15a
Type: Safety Biomarker (SAF)
Genes: MIR15A
Study 23396142 — Biomarker: miR-423
Type: Safety Biomarker (SAF)
Genes: MIR423
Study 23396142 — Biomarker: miR-122
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: MIR122
Study 23396142 — Biomarker: miR-16
Type: Safety Biomarker (SAF)
Study 9562581 — Biomarker: Interleukin 2
Type: Safety Biomarker (SAF)
Genes: IL2
Study 24216543 — Biomarker: Immunoglobulin E
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Study 20224285 — Biomarker: Apolipoprotein E
Type: Predictive Biomarker (PRD)
Genes: APOE
Study 14756017 — Biomarker: HR mRNA
Type: Predictive Biomarker (PRD)
Genes: HR
Study 1372668 — Biomarker: ITGB2 mRNA
Type: Predictive Biomarker (PRD)
Genes: ITGB2; CD18; MFI7
Study 31578173 — Biomarker: BPI mRNA
Type: Predictive Biomarker (PRD)
Genes: BPI
Study 24383843 — Biomarker: BCR mRNA
Type: Predictive Biomarker (PRD)
Genes: BCR; BCR1; D22S11
Study 24383843 — Biomarker: Tyrosine-protein kinase ABL1
Type: Pharmacodynamic Biomarker (PDY)
Genes: ABL1; ABL; JTK7
Study 22828088 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 17611565 — Biomarker: SCT mRNA
Type: Predictive Biomarker (PRD)
Genes: SCT
Study 31070709 — Biomarker: Epidermal growth factor receptor
Type: Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: EGFR; ERBB; ERBB1; HER1
Study 30101416 — Biomarker: Hyaluronic acid
Type: Safety Biomarker (SAF)
Study 31001633 — Biomarker: MPL mRNA
Type: Predictive Biomarker (PRD)
Genes: MPL; TPOR
Study 20530591 — Biomarker: Homovanillic acid
Type: Pharmacodynamic Biomarker (PDY)
Study 19861667 — Biomarker: Cervical intraepithelial neoplasia
Type: Surrogate Endpoint (SUR)
Study 11817713 — Biomarker: Biliary glycoprotein 1
Type: Safety Biomarker (SAF)
Genes: CEACAM1; BGP; BGP1
Study 31037967 — Biomarker: BRCA1 mRNA
Type: Predictive Biomarker (PRD)
Genes: BRCA1; RNF53
Study 19091800 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 9789914 — Biomarker: CD4 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD4
Study 2680272 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 23219613 — Biomarker: MAS1 mRNA
Type: Predictive Biomarker (PRD)
Genes: MAS1; MAS
Study 10714852 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 8985717 — Biomarker: CRH mRNA
Type: Predictive Biomarker (PRD)
Genes: CRH
Study 8985717 — Biomarker: POMC
Type: Predictive Biomarker (PRD)
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 27938853 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 27938853 — Biomarker: Serum uric acid
Type: Surrogate Endpoint (SUR)
Study 10634389 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 30476246 — Biomarker: Bone mineral density
Type: Surrogate Endpoint (SUR)
Study 30476246 — Biomarker: Estrogen receptor
Type: Predictive Biomarker (PRD)
Genes: ESR1; ESR; NR3A1
Study 30476246 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 25399733 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 25399733 — Biomarker: Total kidney volume
Type: Surrogate Endpoint (SUR)
Study 25399733 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 19762332 — Biomarker: MVP mRNA
Type: Predictive Biomarker (PRD)
Genes: MVP; LRP
Study 20585342 — Biomarker: GATA4 mRNA
Type: Predictive Biomarker (PRD)
Genes: GATA4
Study 20585342 — Biomarker: Natriuretic peptides A
Type: Safety Biomarker (SAF)
Genes: NPPA; ANP; PND
Study 9610900 — Biomarker: Granulocyte-macrophage colony-stimulating factor
Type: Safety Biomarker (SAF)
Genes: CSF2; GMCSF
Study 9610900 — Biomarker: White blood cell
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Study 26966867 — Biomarker: AMD1 mRNA
Type: Predictive Biomarker (PRD)
Genes: AMD1; AMD
Study 25487431 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 30416026 — Biomarker: Interleukin 6
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: IL6; IFNB2
Study 30416026 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 14530809 — Biomarker: Hormone receptor
Type: Predictive Biomarker (PRD)
Study 8181328 — Biomarker: Forced vital capacity
Type: Surrogate Endpoint (SUR)
Study 24968966 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 18691861 — Biomarker: FEV mRNA
Type: Predictive Biomarker (PRD)
Genes: FEV; PET1
Study 10708933 — Biomarker: Free fatty acids
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY)
Study 30701736 — Biomarker: MB mRNA
Type: Predictive Biomarker (PRD)
Genes: MB
Study 11126034 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 1388878 — Biomarker: CD4 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD4
Study 3902200 — Biomarker: Adrenomedullin
Type: Safety Biomarker (SAF); Monitoring Biomarker (MOI)
Genes: ADM; AM
Study 16461961 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 29723339 — Biomarker: Platelet-derived growth factor B
Type: Pharmacodynamic Biomarker (PDY)
Genes: PDGFB; PDGF2; SIS
Study 16497687 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 14600550 — Biomarker: Plasminogen activator inhibitor
Type: Safety Biomarker (SAF)
Genes: SERPINE1; PAI1; PLANH1
Study 26997623 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 26997623 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 20581351 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 20581351 — Biomarker: Matrix metalloproteinase 9
Type: Pharmacodynamic Biomarker (PDY)
Genes: MMP9; CLG4B
Study 20581351 — Biomarker: Reactive oxygen species
Type: Safety Biomarker (SAF)
Study 31533151 — Biomarker: Hyaluronic acid
Type: Safety Biomarker (SAF)
Study 17317184 — Biomarker: BRCA1 mRNA
Type: Predictive Biomarker (PRD)
Genes: BRCA1; RNF53
Study 17317184 — Biomarker: BRCA2 mRNA
Type: Predictive Biomarker (PRD)
Genes: BRCA2; FACD; FANCD1
Study 27831492 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 26608649 — Biomarker: Bone mineral density
Type: Surrogate Endpoint (SUR)
Study 18499600 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 20406576 — Biomarker: GARS1 mRNA
Type: Predictive Biomarker (PRD)
Genes: GARS1; GARS
Study 27378086 — Biomarker: Cellular tumor antigen p53
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: TP53; P53
Study 16015255 — Biomarker: Serum triglycerides
Type: Surrogate Endpoint (SUR)
Study 12551869 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 31452425 — Biomarker: PNN mRNA
Type: Predictive Biomarker (PRD)
Genes: PNN; DRS; MEMA
Study 11486442 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 11486442 — Biomarker: Estrogen receptor
Type: Predictive Biomarker (PRD)
Genes: ESR1; ESR; NR3A1
Study 31022403 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 28669885 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 22994935 — Biomarker: Bone mineral density
Type: Surrogate Endpoint (SUR)
Study 18413439 — Biomarker: Vitamin D-binding protein
Type: Predictive Biomarker (PRD)
Genes: GC
Study 18413439 — Biomarker: Interleukin 6
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: IL6; IFNB2
Study 9806676 — Biomarker: MB mRNA
Type: Predictive Biomarker (PRD)
Genes: MB
Study 29442459 — Biomarker: STS mRNA
Type: Predictive Biomarker (PRD)
Genes: STS; ARSC1
Study 16491317 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 19157102 — Biomarker: Serum creatinine
Type: Surrogate Endpoint (SUR)
Study 14712886 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 21781528 — Biomarker: BRCA1 mRNA
Type: Predictive Biomarker (PRD)
Genes: BRCA1; RNF53
Study 17126116 — Biomarker: Serum creatinine
Type: Surrogate Endpoint (SUR)
Study 11438417 — Biomarker: TWIST1 mRNA
Type: Predictive Biomarker (PRD)
Genes: TWIST1; BHLHA38; TWIST
Study 9150331 — Biomarker: Forced vital capacity
Type: Surrogate Endpoint (SUR)
Study 8429112 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 8429112 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 8833174 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 8833174 — Biomarker: Serum LDL cholesterol
Type: Surrogate Endpoint (SUR)
Study 8833174 — Biomarker: High density lipoprotein cholesterol
Type: Pharmacodynamic Biomarker (PDY)
Study 29889764 — Biomarker: Bone mineral density
Type: Surrogate Endpoint (SUR)
Study 27015283 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 24692050 — Biomarker: Bone mineral density
Type: Surrogate Endpoint (SUR)
Study 8002535 — Biomarker: CORT mRNA
Type: Predictive Biomarker (PRD)
Genes: CORT; UNQ307/PRO350
Study 28732324 — Biomarker: AMH mRNA
Type: Predictive Biomarker (PRD)
Genes: AMH; MIF
Study 23427334 — Biomarker: KITLG mRNA
Type: Predictive Biomarker (PRD)
Genes: KITLG; MGF; SCF
Study 24324046 — Biomarker: B-type natriuretic peptide
Type: Safety Biomarker (SAF)
Genes: NPPB
Study 30311085 — Biomarker: Bacterial count
Type: Surrogate Endpoint (SUR)
Study 20329605 — Biomarker: Serum uric acid
Type: Surrogate Endpoint (SUR)
Study 28608165 — Biomarker: CD40 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD40; TNFRSF5
Study 26243374 — Biomarker: POMC
Type: Predictive Biomarker (PRD)
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 22905856 — Biomarker: Serum creatinine
Type: Surrogate Endpoint (SUR)
Study 12860551 — Biomarker: Bone mineral density
Type: Surrogate Endpoint (SUR)
Study 9259041 — Biomarker: White blood cell
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Study 27181566 — Biomarker: GPI mRNA
Type: Predictive Biomarker (PRD)
Genes: GPI
Study 24798870 — Biomarker: CCR2 mRNA
Type: Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY)
Genes: CCR2; CMKBR2
Study 22695756 — Biomarker: COMT mRNA
Type: Predictive Biomarker (PRD)
Genes: COMT
Study 22695756 — Biomarker: Exhaled carbon monoxide
Type: Surrogate Endpoint (SUR)
Study 20484175 — Biomarker: CCND1
Type: Predictive Biomarker (PRD)
Genes: U21B31
Study 7626318 — Biomarker: Serum albumin
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY)
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 31742316 — Biomarker: Gastric inhibitory polypeptide
Type: Pharmacodynamic Biomarker (PDY)
Genes: GIP
Study 31742316 — Biomarker: CCK mRNA
Type: Predictive Biomarker (PRD)
Genes: CCK
Study 31742316 — Biomarker: PYY mRNA
Type: Predictive Biomarker (PRD)
Genes: PYY
Study 31742316 — Biomarker: NTM mRNA
Type: Predictive Biomarker (PRD)
Genes: NTM; IGLON2; NT; UNQ297/PRO337
Study 26071975 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 26071975 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 21917762 — Biomarker: Apolipoprotein E
Type: Predictive Biomarker (PRD)
Genes: APOE
Study 21917762 — Biomarker: Valproic acid
Type: Pharmacodynamic Biomarker (PDY)
Study 19853690 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 27863609 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 18555933 — Biomarker: Free fatty acids
Type: Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY)
Study 15473116 — Biomarker: HR mRNA
Type: Predictive Biomarker (PRD)
Genes: HR
Study 23658561 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 16117969 — Biomarker: Interferon gamma
Type: Safety Biomarker (SAF); Monitoring Biomarker (MOI)
Genes: IFNG
Study 10760830 — Biomarker: EFS mRNA
Type: Predictive Biomarker (PRD)
Genes: EFS; CASS3
Study 31667338 — Biomarker: Erbb2 tyrosine kinase receptor
Type: Predictive Biomarker (PRD)
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 31667338 — Biomarker: Hormone receptor
Type: Predictive Biomarker (PRD)
Study 31667338 — Biomarker: Estrogen receptor
Type: Predictive Biomarker (PRD)
Genes: ESR1; ESR; NR3A1
Study 18664319 — Biomarker: FMOD mRNA
Type: Predictive Biomarker (PRD)
Genes: FMOD; FM; SLRR2E
Study 10931021 — Biomarker: Forced vital capacity
Type: Surrogate Endpoint (SUR)
Study 19454638 — Biomarker: CCS mRNA
Type: Predictive Biomarker (PRD)
Genes: CCS
Study 12238641 — Biomarker: Serum triglycerides
Type: Surrogate Endpoint (SUR)
Study 12238641 — Biomarker: Plasminogen activator inhibitor
Type: Safety Biomarker (SAF)
Genes: SERPINE1; PAI1; PLANH1
Study 10443645 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 7805238 — Biomarker: Endothelin-1
Type: Safety Biomarker (SAF); Monitoring Biomarker (MOI)
Genes: EDN1
Study 2129678 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 7043175 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 7043175 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 31764094 — Biomarker: CD4 mRNA
Type: Predictive Biomarker (PRD)
Genes: CD4
Study 8772218 — Biomarker: von Willebrand factor
Type: Safety Biomarker (SAF)
Genes: VWF; F8VWF
Study 23413906 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 20938778 — Biomarker: C1QL1 mRNA
Type: Predictive Biomarker (PRD)
Genes: C1QL1; C1QRF; CRF; CTRP14
Study 19807760 — Biomarker: Hyaluronic acid
Type: Safety Biomarker (SAF)
Study 17325686 — Biomarker: CCK mRNA
Type: Predictive Biomarker (PRD)
Genes: CCK
Study 11848167 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 31840162 — Biomarker: Serum uric acid
Type: Surrogate Endpoint (SUR)
Study 31840162 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 29789393 — Biomarker: Matrix metalloproteinase 9
Type: Pharmacodynamic Biomarker (PDY)
Genes: MMP9; CLG4B
Study 25317990 — Biomarker: Epidermal growth factor receptor
Type: Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: EGFR; ERBB; ERBB1; HER1
Study 22228146 — Biomarker: NPEPPS mRNA
Type: Predictive Biomarker (PRD)
Genes: NPEPPS; PSA
Study 18557715 — Biomarker: Serum creatinine
Type: Surrogate Endpoint (SUR)
Study 6352119 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 21920481 — Biomarker: C-reactive protein
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: CRP; PTX1
Study 16083541 — Biomarker: Low-density lipoprotein
Type: Pharmacodynamic Biomarker (PDY)
Study 16083541 — Biomarker: High density lipoprotein cholesterol
Type: Pharmacodynamic Biomarker (PDY)
Study 12372444 — Biomarker: FCGR3B
Type: Predictive Biomarker (PRD)
Genes: CD16; CD16b; FcgammaRIIIb; FcRIIIb
Study 7586108 — Biomarker: HR mRNA
Type: Predictive Biomarker (PRD)
Genes: HR
Study 29607525 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 29607525 — Biomarker: High density lipoprotein cholesterol
Type: Pharmacodynamic Biomarker (PDY)
Study 12827578 — Biomarker: Reactive oxygen species
Type: Safety Biomarker (SAF)
Study 12827578 — Biomarker: Pulmonary vascular resistance
Type: Surrogate Endpoint (SUR)
Study 9766154 — Biomarker: Angiotensin-converting enzyme
Type: Pharmacodynamic Biomarker (PDY)
Genes: ACE; DCP; DCP1
Study 27355239 — Biomarker: TTR mRNA
Type: Predictive Biomarker (PRD)
Genes: TTR; PALB
Study 24796766 — Biomarker: AMH mRNA
Type: Predictive Biomarker (PRD)
Genes: AMH; MIF
Study 23174579 — Biomarker: Cystatin C
Type: Safety Biomarker (SAF)
Genes: CST3
Study 20236550 — Biomarker: Tumor necrosis factor
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: TNF; TNFA; TNFSF2
Study 20236550 — Biomarker: Interleukin 8
Type: Predictive Biomarker (PRD); Safety Biomarker (SAF)
Genes: CXCL8; IL8
Study 18608197 — Biomarker: Blood pressure
Type: Surrogate Endpoint (SUR)
Study 28503826 — Biomarker: Pathological complete response
Type: Surrogate Endpoint (SUR)
Study 25910950 — Biomarker: Vascular endothelial growth factor receptor 2
Type: Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY)
Genes: KDR; FLK1; VEGFR2
Study 25910950 — Biomarker: Epidermal growth factor receptor
Type: Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI)
Genes: EGFR; ERBB; ERBB1; HER1
Study 25910950 — Biomarker: RET mRNA
Type: Predictive Biomarker (PRD)
Genes: RET; CDHF12; CDHR16; PTC; RET51