87value/wos11967 huggingface dataset:
At present, China's grain production pattern runs counter to the distribution patterns of farmland resources and water-heat conditions. It is urgently important to conduct research on the spatial matching of grain production and farmland resources. Based on the Potential Crop Rotation data, with regards to the situations of irrigation and rain feeding, this paper builds a measuring model of potential farmland, and separately measures the spatial matching/index of grain yield with actual and potential farmland resources, thus revealing China's grain production pattern. The results indicate that serious spatial mismatch exists between grain production and farmland resources in China. Take the potential crop rotation system into consideration, the spatial mismatch of grain yield and potential farmland resources has been aggravated by the grain production barycenter's shift to the north China, with low Crop Rotation Index. The function-promoting regions of grain production in China are going through two evolution patterns of northward and southward expansion and westward movement and northward expansion, respectively. Inefficient use of farmland mainly occurs in the fragile ecological environments, such as the farming-pastoral ecotone of Northern China, the northwest area of Xinjiang and the southwest karst landform areas. The inefficient use of and the decreasing amount of available farmland have become the main causes of the decline in grain production. The problems facing Chinese agriculture caused by the spatial mismatch include the imbalance in regional structures, ecological risks, agricultural production risks, and the risk of food price. In order to cope with these problems, this paper provides some advices on protecting farmland acreage, expanding farmland potential, ensuring the safety of water resources, and extending the industrial grain chain. Our paper additionally proposes policy reforms and innovations designed to ensure the implementation of the above measures, so as to commonly defuse China's food security crisis. (C) 2016 Elsevier Ltd. All rights reserved.
The UN Convention on the rights of persons with disabilities (UNCRPD) [1] puts a focus on accessibility and technology. Both are considered as a precondition and means to support full participation of people. Today, new technologies provide new options for the support of all people including people with disabilities. The concepts assistive technology and accessibility begin to merge into Technology Based Accessibility (TBA). TBA has the potential to make a significant change in the lives of people with disabilities.
Referring to two recent publications, we here propose that clinical reproductive immunology has for decades stagnated because reproductive medicine, including assisted reproduction (AR), has failed to accept embryo implantation as an immune system-driven process, dependent on establishment of maternal tolerance toward the implanting fetal semi-allograft (and complete allograft in cases of oocyte donation). Pregnancy represents a biologically unique period of temporary (to the period of gestation restricted) tolerance, otherwise only known in association with parasitic infections. Rather than investigating the immune pathways necessary to induce this rather unique state of tolerance toward the rapidly growing parasitic antigen load of the fetus, the field, instead, concentrated on irrelevant secondary immune phenomena (i.e., immunological noise). It, therefore, does not surprise that interesting recent research, offering new potential insights into maternal tolerance during pregnancy, was mostly published outside of the field of reproductive medicine. This research offers evidence for existence of inducible maternal tolerance pathways with the ability of improving maternal fecundity and, potentially, reducing such late pregnancy complications as premature labor and preeclampsia/eclampsia due to premature abatement of maternal tolerance. Increasing evidence also suggests that tolerance-inducing immune pathways are similar in successful pregnancy, successful organ transplantation and, likely also in the tolerance of self (i.e., prevention of autoimmunity). Identifying and isolating these pathways, therefore, may greatly benefit all three of these clinical areas, and research in reproductive immunology should be accordingly redirected.
Hallucinogenic tryptamine analogues, an important class of drugs of abuse, can be naturally occurring or chemically synthesized compounds. In Japan, psilocin and psilocybin (ingredients of magic mushrooms) and 5-methoxy-N,N-diisopropyltryptamine (5-MeO-DIPT; a synthetic tryptamine) seem to be particularly problematic due to their extensive abuse. This review is focused on human metabolism and forensic toxicological analyses of the above three tryptamine analogues. In humans, psilocybin is rapidly dephosphorylated to form psilocin, and most of the psilocin is eventually conjugated to form its glucuronide. On the other hand, 5-MeO-DIPT is mainly metabolized via O-demethylation, 6-hydroxylation, and N-deisopropylation, partly followed by conjugation to form their sulfates and glucuronides. Suitable hydrolysis should be, therefore, applied for sensitive and effective analysis of the metabolites. In analyzing psilocin and psilocybin by gas chromatography-mass spectrometry (GC-MS), derivatization is necessary for their discriminative identification. Although 5-MeO-DIPT and its three major metabolites can be analyzed by GC-MS without any derivatization, trimethylsilyl derivatization provides improvement of their peak shapes and intensities. In contrast to GC-MS, liquid chromatography-mass spectrometry and liquid chromatography-tandem mass spectrometry allow us not only to discriminate psilocin and psilocybin without derivatization, but also to directly analyze their conjugated metabolites.
In an urban highway network system such as Tokyo Metropolitan Expressway. to detect conditions of road pavement and expansion Joints is a very important issue. Although accurate surface condition can be captured by using a road profiler system, the operating cost is expensive and development of a simpler and more inexpensive system is really needed to reduce monitoring cost. Vehicle Intelligent Monitoring System (VIMS) developed for this purpose is described in this paper. An accelerometer and GPS are installed to an ordinary road patrol car. GPS together with a PC computer are used to measure the road surface condition and to identify the location of the vehicle, respectively Dynamic response of the vehicle is used as a measure of the road pavements surface condition as well as the expansion joints. A prototype of VIMS is installed to a motor car and measurement is made at the actual roads. Accuracy of measuring result and effectiveness of this system are demonstrated; the outline of the system and some of the measurement results are reported herein.
Computer-aided design (CAD) models of thin-walled solids such as sheet metal or plastic parts are often reduced dimensionally to their corresponding midsurfaces for quicker and fairly accurate results of computer-aided engineering (CAE) analysis. Computation of the midsurface is still a time-consuming and mostly, a manual task due to lack of robust and automated techniques. Most of the existing techniques work on the final shape (typically in the form of boundary representation, B-rep). Complex B-reps make it hard to detect subshapes for which the midsurface patches are computed and joined, forcing usage of hard-coded heuristic rules, developed on a case-by-case basis. Midsurface failures manifest in the form of gaps, overlaps, nonmimicking input model, etc., which can take hours or even days to correct. The research presented here proposes to address these problems by leveraging feature-information available in the modern CAD models, and by effectively using techniques like simplification, abstraction, and decomposition. In the proposed approach, first, the irrelevant features are identified and removed from the input FbCAD model to compute its simplified gross shape. Remaining features then undergo abstraction to transform into their corresponding generic Loft-equivalents, each having a profile and a guide curve. The model is then decomposed into cellular bodies and a graph is populated, with cellular bodies at the nodes and fully overlappingsurface- interfaces at the edges. The nodes are classified into midsurface-patch generating nodes (called solid cellsor sCells) and interaction-resolving nodes (interface cells or iCells). In a sCell, a midsurface patch is generated either by offset or by sweeping the midcurve of the owner-Loft-feature's profile along with its guide curve. Midsurface patches are then connected in the iCells in a generic manner, thus resulting in a wellconnected midsurface with minimum failures. Output midsurface is then validated topologically for correctness. At the end of this paper, real-life parts are used to demonstrate the efficacy of the proposed approach.
Inflammation is an elaborate reflex response of the body to the action of harmful agents. This reaction manifests itself in the form of functional and structural changes of vascular tissues. The inflammatory response is the result of the human evolutionary process. It has three main stages, which are closely related to each other and evolve simultaneously: tissue dystrophy (alteration); impairment of blood circulation (transudation of fluid and migration of leukocytes) and multiplication of cellular elements (proliferation). These phenomena express both a disturbance of biological activity in body tissues and the defense mechanisms to restore the damaged areas. There are two interrelated processes which are often inseparable from each other in the inflammatory response. First, there is the pathological process itself, the tissue damage in form of dystrophy, necrobiosis or necrosis. Second, there is the physiological mechanism of defense, the process of recovery or the physiological response against the disease, manifested as exudation, phagocytosis and proliferation. Simultaneity of both processes is characteristic to inflammatory processes.
Most prokaryote-secreted proteins are transported to the cell surface using either the general secretion (Sec) or twin-arginine translocation (Tat) pathway. A majority of secreted proteins are anchored to the cell surface, while the remainder are released into the extracellular environment. The anchored surface proteins play a variety of important roles in cellular processes, ranging from facilitating interactions between cells to maintaining cell stability. The extensively studied S-layer glycoprotein (SLG) of Haloferax volcanii, previously thought to be anchored via C-terminal intercalation into the membrane, was recently shown to be lipidated and to have its C-terminal segment removed in processes dependent upon archaeosortase A (ArtA), a recently discovered enzyme. While SLG is a Sec substrate, in silico analyses presented here reveal that, of eight additional ArtA substrates predicted, two substrates also contain predicted Tat signal peptides, including Hvo_0405, which has a highly conserved tripartite structure that lies closer to the center of the protein than to its C terminus, unlike other predicted ArtA substrates identified to date. We demonstrate that, even given its atypical location, this tripartite structure, which likely resulted from the fusion of genes encoding an ArtA substrate and a cytoplasmic protein, is processed in an ArtA-dependent manner. Using an Hvo_0405 mutant lacking the conserved twin arginines of the predicted Tat signal peptide, we show that Hvo_0405 is indeed a Tat substrate and that ArtA substrates include both Sec and Tat substrates. Finally, we confirmed the Tat-dependent localization and signal peptidase I (SPase I) cleavage site of Hvo_0405 using mass spectrometry. IMPORTANCE The specific mechanisms that facilitate protein anchoring to the archaeal cell surface remain poorly understood. Here, we have shown that the proteins bound to the cell surface of the model archaeon H. volcanii, through a recently discovered novel ArtA-dependent anchoring mechanism, are more structurally diverse than was previously known. Specifically, our results demonstrate that both Tat and Sec substrates, which contain the conserved tripartite structure of predicted ArtA substrates, can be processed in an ArtA-dependent manner and that the tripartite structure need not lie near the C terminus for this processing to occur. These data improve our understanding of archaeal cell biology and are invaluable for in silico subcellular localization predictions of archaeal and bacterial proteins.
Imagination pushes humanity well beyond its natural biological capacities. An approach of co-evolution, between molecular biology and behaviour, is thus required to explain these combined processes. Technological performances define spiritual conquests and formulas whose sole function is cultural. Humanity operates according to intentional social modes defined by the group, but these immediately become conditions for their own evolution. These choices are the motor for the history of humanity, and thus humanity can itself choose its own path. Anatomic modernisation is only a distant reflection of bipedalism, but freeing the hands leads to the development of abstract thought. The relationship between anatomy and awareness allows infinite variations in the harmonious adaptation to nature, animals and other societies. In Europe, humanity arrived in abrupt bursts because it was the result of external evolution, continuous and distant, dispersed across Asia. By its unceasing audacity, humanity combats biological determinism, imposing moral rules, or imperatives. The balance between biology and culture is reflected in the rules for sharing food: the biological life itself is coded by social sharing. These systems take on ternary values as soon as they include animal behaviours. Built shelters integrate societies with the cosmos because they delimit cultural spaces within natural chaos. Mastery of cognitive mechanisms gives humanity an entirely new responsibility, that of being able to define its destiny. Our united disciplines are transformed into ethical requirements. (C) 2016 Published by Elsevier Masson SAS on behalf of Academie des sciences.
Using a person perception paradigm, two studies explored the interplay between target males' sociability and competence (the big two personality dimensions), gender role, and sexual orientation. Study 1 (N = 180) showed that sociable men were considered more likely to be gay than were competent men, which was mediated by the attribution of lower masculinity. In Study 2 (N = 120), target sexual orientation was considered as an independent variable. In the stereotype-congruent condition (gay/sociable vs. heterosexual/competent), gay men were rated more feminine and less masculine than were heterosexual men, whereas in the stereotype-incongruent condition (gay/competent vs. heterosexual/sociable), gay targets were rated less feminine but only equally masculine. Across both studies, the apparent stereotype of the nice gay guy was uncorrelated with participants' attitudes toward or contact with gay men. Results are discussed with regard to the gender-inversion hypothesis, the distinction between (anti) gay stereotypes and prejudice, and the stereotype content model.
Our study used allozyme analyses to evaluate potential impacts of ecological restoration treatments on genetic diversity of ponderosa pine (Pinus ponderosa var. scopulorum) populations within the Fort Valley Experimental Forest near Flagstaff, AZ. Allele frequencies varied among pre-settlement clumps, with trees more closely related to each other within clumps. This clumpy spatial stand structure typical of reference conditions thus represents genetic neighborhoods and suggests restoration of clumpy versus more evenly dispersed trees in naturally regenerating stands will protect evolutionary genetic patterns. Compared to pre-settlement populations, post-settlement trees had slightly greater heterozygosity, and allelic richness and allele frequencies varied between these two age groups. These genetic differences could have resulted from different selective conditions under which the two age groups became established. Genetic diversity of populations created using different selection criteria for residual post-settlement trees did not vary but simulated removal of 75% of post-settlement trees decreased allelic richness. Maintaining more clumps created from post-settlement populations with higher tree densities across the landscape would be more effective at conserving allelic richness. Overall results of this study indicate use of genetic structure and diversity can help guide restoration treatments to help ensure adaptive potential is conserved.
This paper presents a non-verbal and non-facial method for effective communication of a mechanoid robot by conveying the emotions through gestures. This research focuses on human-robot interaction using a mechanoid robot that does not possess any anthropomorphic facial features for conveying gestures. Another feature of this research is the use of human-like smooth motion of this mechanoid robot in contrast to the traditional trapezoidal velocity profile for its communication. For conveying gestures, the connection between motion of robot and perceived emotions is established by varying the velocity and acceleration of the mechanoid structure. The selected motion parameters are changed systematically to observe the variation in perceived emotions. The perceived emotions have been further investigated using three different emotional behavior models: Russell's circumplex model of affect, Tellegen-Watson-Clark model and PAD model. Results obtained show that the designated motion parameters are linked with the change of emotions. Moreover, the emotions perceived by the user are same through all three models, validating the reliability of all the three emotional scale models and also of the emotions perceived by the user.
It has been stated that roughly 50% of electrical incidents involve workers whose primary function is not electrical in nature. It also encouraged all to address electrical safety for all workers and not just workers whose job responsibilities involve working on or near energized electrical circuits. In this paper, a program which includes specific briefings to non-electrical workers as well as to workers who may need to perform their normal activities in proximity to energized electrical conductors is presented. The program uses a targeted approach to specific areas such as welding, excavating, rigging, chart reading, switching, cord and plug equipment and several other general areas to point out hazards that may exist and how to avoid them. The site experience over the years supports the assertion that about half of the electrical incidents involve non-electrical workers and this prompted us to develop specific briefings to enhance the knowledge of the non-electrical worker regarding safe electrical practices. The promotion of May is Electrical Safety Month and the development of informative presentations which are delivered to the general site population as well as electrical workers have greatly improved the hazards awareness status of the general worker on site.
Rationale Social cognition influences social interactions. Alcohol reportedly facilitates social interactions. However, the acute effects of alcohol on social cognition are relatively poorly studied. We investigated the effects of alcoholic or non-alcoholic beer on emotion recognition, empathy, and sexual arousal using the dynamic face emotion recognition task (FERT), Multifaceted Empathy Test (MET), and Sexual Arousal Task (SAT) in a double-blind, random-order, cross-over study in 60 healthy social drinkers. We also assessed subjective effects using visual analog scales (VASs), blood alcohol concentrations, and plasma oxytocin levels. Alcohol increased VAS ratings of stimulated, happy, talkative, open, and want to be with others. The subjective effects of alcohol were greater in participants with higher trait inhibitedness. Alcohol facilitated the recognition of happy faces on the FERT and enhanced emotional empathy for positive stimuli on the MET, particularly in participants with low trait empathy. Pictures of explicit sexual content were rated as less pleasant than neutral pictures after non-alcoholic beer but not after alcoholic beer. Explicit sexual pictures were rated as more pleasant after alcoholic beer compared with non-alcoholic beer, particularly in women. Alcohol did not alter the levels of circulating oxytocin. Alcohol biased emotion recognition toward better decoding of positive emotions and increased emotional concern for positive stimuli. No support was found for a modulatory role of oxytocin. Alcohol also facilitated the viewing of sexual images, consistent with disinhibition, but it did not actually enhance sexual arousal. These effects of alcohol on social cognition likely enhance sociability. www.clinicaltrials.gov/ct2/show/NCT02318823 RefTarget Address=http://www.clinicaltrials.gov/ct2/show/NCT02318823 TargetType=URL/>
We investigated the role of self-focused attention (SFA) in social anxiety (disorder) in an ecologically valid way. In Experiment 1 high (n = 26) versus low (n = 25) socially anxious single women between 18 and 30 years had a video (Slcype) conversation with an attractive male confederate, while seeing themselves and the confederate on-screen. The conversation was divided in four phases: (I) warm-up, (II) positive (confederate was friendly to the participant), (III) critical (confederate was critical to the participant), and (IV) active (participant was instructed to ask questions to the confederate). Participant's SFA was measured by eye-tracked gaze duration at their own image relative to the confederates' video image and other places at the computer screen. Results show that high socially anxious participants were more self-focused in the critical phase, but less self-focused in the active phase than low socially anxious participants. In Experiment 2 women diagnosed with SAD (n = 32) and controls (n = 30) between 18 and 30 years conducted the same experiment. Compared to controls participants with SAD showed increased SFA across all four phases of the conversation, and SFA predicted increased self-rated anxiety during the conversation. In conclusion, in subclinical social anxiety SFA is high only when the interaction partner is critical, whereas instructions to ask questions to the confederate reduces subclinical socially anxious' SFA, while clinical SAD is characterized by heightened self-focused attention throughout the interaction. Results support theories that social anxiety disorder is maintained by SFA, and imply that interventions that lower SFA may help prevent and treat social anxiety disorder, but that SFA can also be adaptive in certain types of interaction, such as when receiving compliments. (C) 2017 Elsevier Ltd. All rights reserved.
Throughout the United States, there has been a rise in public discourse about transgender people and transgender issues. Much of this attention stems from passed and proposed anti-LGBTQ (lesbian, gay, bisexual, transgender, queer or questioning) legislation, including bathroom bills that would require transgender people to use public facilities corresponding with the sex designated on their birth certificates. With the recent discussion and legislation impacting school-aged children and adolescents, what does this mean for school nurses and how can they care and advocate for their transgender students? In this article, we aim to empower school nurses to join the discussion, advocate for inclusive and equitable school policies, and deliver gender-affirming care to transgender students. We will explain transgender identities; transgender-related stigma, prejudice, discrimination, and health concerns; gender-affirming approaches in caring for transgender youth; and implications for school nurses. School nurses play a key role in creating a space that is welcoming and affirming where transgender students can thrive.