87value/wos11967 huggingface dataset:
Introduction: Although social cognition skills and biases are well-studied in paranoia, mind perception - perceiving the extent to which someone even possesses a thinking, feeling mind - is not. We sought to better characterise the profile of mind perception for individuals with paranoia. Methods: We examined links between mind perception and paranoia in a large (n = 890) subclinical sample. Participants completed measures of paranoia, schizotypy, mind perception, and dispositional empathy. These assessments were examined for their relationships to one another, as well as the possibility that mind perception partially mediates the relationship between paranoia and empathy. Results: Analyses revealed that increased paranoia was linked to less mind perception towards people. This distorted mind perception partially explained the link between paranoia and both perspective taking and empathic concern. Conclusions: In paranoia - and psychopathology more broadly understanding and addressing distorted mind perception may be one component of restoring social functioning.
Background: Autism spectrum disorders (ASDs) are developmental conditions characterized by deficits in social interaction, impairments in verbal and nonverbal communication, and stereotyped patterns of behavior. Previous studies have implicated environmental factors in the development of ASD. Although no reliable neurophysiological network is associated with ASD, low levels of plasma oxytocin (OXY) and arginine vasopressin (AVP) have been reported. The twin nonapeptides OXY and AVP are mainly produced in the brain of mammals, and dysregulation of these neuropeptides has been associated with changes in behavior, especially social interactions. Methods: Previously, we analyzed 91 commonly used fragrances and reported significant mutagenic, neurocytotoxic, and stimulatory effects on fetal neuroblastoma cell lines (NBC). In this study, we analyzed the neuromodifications of three selected fragrances on male and female human fetal brain neurons, utilizing immunohistochemistry. Results: We show that exposure to femtomolar concentrations of fragrances results in morphological changes by light microscopy in the NBC. Importantly, these fragrances significantly reduced the OXY- and AVP-receptor positive (OXYR+ and AVPR+) neurons in male NBC but not in female NBC, possibly contributing to the development of male bias in ASD. Conclusion: This study is the first to show a potential link between fragrance exposure, depletion of OXYR+ and AVPR+ neurons, and a male bias in autism. (C) 2015 Elsevier Inc. All rights reserved.
Mott cells are atypical plasmacytes recognized microscopically by endoplasmic reticulum (ER) distensions (Russell bodies) a result of retained secretory product (antibody). Originally associated with parasitism, they are observed in a broad spectrum of immunopathology, sometimes involving hypergammaglobulinemia. Few descriptions of Mott cells appear in avian literature. The purpose of the manuscript is to provide examples identified by light microscopy in three poultry species. Transmission electron micrographs (TEM) of plasmacytes from the turkey oviduct mucosa are included for comparison with Mott cell light microscopic images. Wright's stained blood and bone marrow from commercial and specific pathogen free (SPF) chickens, ducks, and turkeys are the sources. Mott cell positive samples commonly occurred with leukocytosis or leukemoid reactions, polymicrobial bacteremia, and fungemia. Atypical granulocytes and leukocytes regularly accompanied Mott cells. It is proposed that circulating Mott cells are sentinels indicative of stress, dyscrasia, and pathology. Moreover, Mott cells, like other atypia, complicate the interpretation of simple heterophil/lymphocyte (H/L) ratios. As Mott cells are defective plasmacytes these observations address hematology, immunology, pathology, and welfare issues.
Most research on threat documents its negative consequences. Similarly, most research on intergroup contexts has emphasized their negative behavioral effects. Drawing on the Meaning Maintenance Model and recent perspectives on the potential for positivity in intergroup conflict, we predicted that meaning threat can produce both antisocial and prosocial responses to intergroup conflict, depending on people's preexisting meaning frameworks. Studies 1 and 2 demonstrated that under meaning threat, low ingroup glorifiers strengthened their support for peaceful conflict resolution, whereas high ingroup glorifiers strengthened their support for military-based conflict resolution. In the context of the Israel-Palestinian conflict, Study 3 found that low glorification was associated with greater support for peace during hot (but not cold) conflict, because hot conflict reduced their meaning in life. These findings are consistent with the notion that when meaning is threatened, people affirm their preexisting values-whether prosocial or antisocial-even in the context of intergroup conflict.
Labeling children's social play behavior is an important process in children's peer-play analysis which is traditionally done by experienced coders. With the growing volume of data, automatic methods for labeling are increasingly required. This paper presents a novel method to classify children's social play behavior in peer-play scenarios into three categories (solitary play, parallel play and group play). Based on the two key cues attentiveness and proximity proposed in The Play Observation Scale, unary features and pairwise features are calculated to describe the relationships between a child and the whole context, and the interactions between two children. Inspired by the recent studies in social behavior analysis and interaction recognition, children's activities are classified by support vector machine (SVM) and hidden conditional random field (HCRF). This method is evaluated by a dataset of children's peer-play scenarios collected by psychology researchers and the results show this method has a good performance in the dataset.
Vulnerability segmentation, the condition under which plant leaves are more vulnerable to drought-induced cavitation than stems, may act as a safety valve to protect stems from hydraulic failure. Evergreen, winter-deciduous, and drought-deciduous tree species co-occur in tropical savannas, but there have been no direct studies on the role of vulnerability segmentation and stomatal regulation in maintaining hydraulic safety in trees with these three leaf phenologies. To this end, we selected three Anacardiaceae tree species co-occurring in a Chinese savanna, evergreen Pistacia weintnanniifolia, drought-deciduous Terminthia paniculata, and winter-deciduous Lannea coromandelica, to study inter-species differentiation in leaf and stem hydraulic safety. We found that the two deciduous species had significantly higher sapwood-specific hydraulic conductivity and leaf-specific hydraulic conductance than the evergreen species. Moreover, two deciduous species were more vulnerable to stem cavitation than the evergreen species, although both drought-deciduous species and evergreen species had drought-resistance leaves. The evergreen species maintained a wide hydraulic safety margin (HSM) in stems and leaves; which was achieved by embolism resistance of both stems and leaves and isohydric stomatal control. Both deciduous species had limited HSMs in stems and leaves, being isohydric in the winter-deciduous species and anisohydric in drought-deciduous species. The difference in water potential at 50% loss of hydraulic conductivity between the leaves and the terminal stems (P5Oleaf-stem) was positive in P weinmanniifolia and L. coromandelica, whereas. T paniculata exhibited a lack of vulnerability segmentation. In addition, differences in hydraulic architecture were found to be closely related to other structural traits, i.e., leaf mass per area, wood density, and sapwood anatomy. Overall, the winter-deciduous species exhibits a drought-avoidance strategy that maintains the hydraulic safety of the more carbon-costly stems by sacrificing cheaper and more vulnerable leaves, while the evergreen species exhibits a hydraulic strategy of drought tolerance with strong stomatal regulation. In contrast, the drought-deciduous species lacks vulnerability segmentation and sheds leaves at the expense of top shoots during peak drought. This study demonstrates that even sympatric tree species that differ in leaf phenology can exhibit divergent adaptive hydraulic safety strategies.
Sinus augmentation procedure has been demonstrated to be a highly predictable treatment in posterior maxilla atrophy. All the surgical interventions in the maxillary region require deep knowledge of anatomy and possible anatomical variations. In this article, pre-operative and post-operative assessments of sinus cavity as well as novel approaches to deepen our knowledge of the behavior of bone substitute materials are described. The awareness of the patient's morphologic conditions enables exact planning of invasive surgery and aids to avoid complications. Pre-operative radiologic evaluation of the region before sinus lift is advisable both for a planning of the sinus augmentation and for selection and alignment of the optimum placement of implants. On the orthopantomography it is possible to measure the vertical dimension of graft, but not the volume and 3D changes. Cone-beam computed tomography (CBCT) has become the gold standard to plan a comprehensive implant treatment and to achieve a post-operative assessment. A computer-aided design/computer-aided manufacturing (CAD/CAM) technique is proposed to produce custom-made block grafts for sinus lift procedure, and a customized cutting guide to accurately place the lateral wall and ease membrane elevation. This procedure allows to reduce intervention time, to precisely adapt the scaffold, to reduce risk of complications and to improve operation quality. Recently, a novel approach has been used to deepen our knowledge of the behavior of BSBs: by means of synchrotron micro-tomography (SCT). It is a 3-D analyzing method, suitable to examine the dynamic and spatial arrangement of regenerative phenomena in complex anatomical structures such as bone, where tissues with several morphologies (alveolar process, unmineralized extracellular matrix, regenerated vessels, etc.) compete to achieve the final goal of bone regeneration.
We investigated the proposal that ankylosing spondylitis (AS) is associated with unusual ERAP1 genotypes. ERAP1 haplotypes were constructed for 213 AS cases and 46 rheumatoid arthritis controls using family data. Haplotypes were generated from five common ERAP1 single nucleotide polymorphisms (SNPs)-rs2287987 (M349V), rs30187 (K528R), rs10050860 (D575N), rs17482078 (R725Q), and rs27044 (Q730E). Haplotype frequencies were compared using Fisher's exact test. ERAP1 haplotypes imputed from the International Genetics of AS Consortium (IGAS) Immunochip study were also studied. In the family study, we identified only four common ERAP1 haplotypes (VRNQE,  MKDRQ,MRDRE, and MKDRE) in both AS cases and controls apart from two rare (<0.5%) previously unreported haplotypes. There were no examples of the unusual ERAP1 haplotype combination (*001/*005) previously reported by others in 53% of AS cases. As expected, K528-bearing haplotypes were increased in the AS family study (AS 43% vs. control 35%), due particularly to an increase in the MKDRQ haplotype (AS 35% vs. control 25%, P = 0.01). This trend was replicated in the imputed Immunochip data for the two K528-bearing haplotypes MKDRQ (AS 33% vs. controls 27%, P = 1.2 x 10(-24)) and MKDRE (AS 8% vs. controls 7%, P = 0.004). The ERAP1 association with AS is therefore predominantly attributable to common ERAP1 haplotypes and haplotype combinations.
In the present study, we investigated the much debated happiness gap between conservatives and liberals, approaching the issue from a multilevel person x context perspective. More specifically, we investigated whether this relationship depends on country-level threat. We used individual-level data for right-wing attitudes and psychological well-being from 94 large, representative samples collected worldwide (total N = 137,890) and objective indicators of country-level threat as the contextual variable. Our results suggest that, especially in countries characterized by high levels of threat, individuals with right-wing attitudes experienced greater well-being than individuals with left-wing attitudes. In countries with a low level of threat, this relationship was considerably weaker or even absent. Our findings corroborate the view that right-wing attitudes may serve a self-protective function, helping individuals to manage and cope with threat.
In this study, we would like to highlight the advantages and disadvantages of distance form of education and ways to improve it because now e-learning has been expanding at a very rapid rate in quantitative terms, and qualitative parameters of DE in Kazakhstan require a detailed analysis. Weighing the objective merits and problem areas of DE, we will try to justify the existing requirements, opportunities and tools of DE and propose ways to improve it in order to higher education institutions of Kazakhstan, including Almaty Management University, could compete in the educational market in the world educational space. The aim of the study is to improve the instruments in the creation of educational products for distance education. It includes evaluation of the advantages and disadvantages of distance learning format at the university, the model of existing distance education: naugramma, determination of weak points in DE implementation, one-way contact problems: causes of a blank shot, transfer of knowledge through the computer monitors, face-to-face contact: verbal and nonverbal communication of a teacher with a student. The conditions for development of DE were recent achievements in technologies of teaching, media and communications, the rapid development and widespread use of a variety of technical means. Primarily, they refer to the computer and information technology, satellite communication systems, educational television, mass connection to information systems and distribution of learning software and videos. To implement the model ''Only Distance Education at the three stages we have analyzed the methods used in DE in secondary education. As an example, we analyzed teaching chemistry at a secondary school for disabled children in Moscow. The research of the first stage (secondary school) and analysis of applying distance form of education at the second stage (university) together with assessment of problematic areas have resulted in creating an effective model. When implemented, this model will work with great efficiency and help to eliminate many difficulties that slow down the realization of the whole package of instruments of Distance Education.
The effects of tissue type, harvest maturity, and genetic factors on the expression of genes that related to citrus fruit allergies remain poorly understood. In the present study, a multiplex real-time PCR assay was developed to monitor the expression of citrus allergen genes individually with the advantages of much fewer sample requirements and simultaneously multiple target genes detection. Gene specific primer pairs and Taqman probes of three citrus allergen genes Cit s 1.01, Cit s 2.01, and Cit s 3.01 and the house-keeping gene beta-actin were designed based on gene sequence differences. The PCR results showed that differential expression patterns were found during the ripening process. The expression levels of Cit s 3.01 were much higher than those of Cit s 1.01 and Cit s 2.01 in both peel and pulp tissues among 10 citrus cultivars. Data suggested that Kao Phuang Pummelo could be safely consumed with a potential low risk in allergenicity. Considering that assessing allergenicity is one of the tests in food safety, this assay might also facilitate the breeding and production of allergy-friendly citrus fruits.
We consider the problem of automatically re-identifying a person of interest seen in a probe camera view among several candidate people in a gallery camera view. This problem, called person re-identification, is of fundamental importance in several video analytics applications. While extracting knowledge from high dimensional visual representations based on the notions of sparsity and regularization has been successful for several computer vision problems, such techniques have not been fully exploited in the context of the re-identification problem. Here, we develop a principled algorithm for the re-identification problem in the general framework of learning sparse visual representations. Given a set of feature vectors for a person in one camera view (corresponding to multiple images as they are tracked), we show that a feature vector representing the same person in another view approximately lies in the linear span of this feature set. Furthermore, under certain conditions, the associated coefficient vector can be characterized as being block sparse. This key insight allows us to design an algorithm based on block sparse recovery that achieves stateof-the-art results in multi-shot person re-identification. We also revisit an older feature transformation technique, Fisher discriminant analysis, and show that, when combined with our proposed formulation, it outperforms many sophisticated methods. Additionally, we show that the proposed algorithm is flexible and can be used in conjunction with existing metric learning algorithms, resulting in improved ranking performance. We perform extensive experiments on several publicly available datasets to evaluate the proposed algorithm. (C) 2016 Elsevier B.V. All rights reserved.
Affective Theory of Mind (ToM) is the specific ability to represent own and others' emotional states and feelings. Previous studies examined affective ToM ability in patients with Huntingtons disease (HD), using the Reading the Mind in the Eyes test (RMET). Results were consistent in showing difficulties in inferring complex mental states from photographs of people even in the early stage of HD. However, there has been no agreement as to whether or not cognitive impairments in HD population might have contributed to poor performance on the RMET test. The aim of the present study was to assess whether the affective ToM ability was impaired in the mild to moderate stages of HD, and whether there was an association between compromised ToM ability and the presence of cognitive impairment. We evaluated ToM by means of RMET and global cognitive functioning by means of the MoCA questionnaire in 15 HD patients and 15 healthy subjects (HS). Both groups were matched for age and level of education. Our study showed that the ability to judge a persons mental states from a picture of their eyes was impaired in HD patients compared to normal population. Indeed, HD subjects gave the 34% of correct responses on RMET, whereas healthy control subjects percentage of correct responses was 71%. Furthermore, this impairment was not correlated with global cognitive functioning except for the visuospatial task. These results show that RMET might represent a valid instrument to assess affective ToM ability in HD patients in the mild to moderate stages of the disease, independently from their cognitive status. Since it is known that HD patients, in addition to motor symptoms, suffer from cognitive deficits, including memory and executive impairments, it is important to have an instrument, which is not influenced by cognitive abilities. It is possible therefore to use RMET to assess important aspects of HD patients such as their ability to recognize others emotions and feelings even when patients suffer from cognitive decline.
Introducing this special issue of Safundi Sequins, Self & Struggle, Catherine M. Cole situates this project, which is focused on two Cape Town beauty pageants, by illuminating how catwalks can become platforms for the doing of rights in contemporary South Africa. Both pageants serve as sanctuaries where participants claim their fabulousness, despite the circumstances of constraint, prejudice, inequality, and even danger in which they perform.
Dysregulated proteostasis is a key feature of a variety of neurodegenerative disorders. In Alzheimer's disease (AD), progression of symptoms closely correlates with spatiotemporal progression of Tau aggregation, with early oligomeric Tau forms rather than mature neurofibrillary tangles (NFTs) considered to be pathogenetic culprits. The ubiquitin-proteasome system (UPS) controls degradation of soluble normal and abnormally folded cytosolic proteins. The UPS is affected in AD and is identified by genomewide association study (GWAS) as a risk pathway for AD. The UPS is determined by balanced regulation of ubiquitination and deubiquitination. In this work, we performed isobaric tags for relative and absolute quantitation (iTRAQ)-based Tau interactome mapping to gain unbiased insight into Tau pathophysiology and to identify novel Tau-directed therapeutic targets. Focusing on Tau deubiquitination, we here identify Otub1 as a Tau-deubiquitinating enzyme. Otub1 directly affected Lys48-linked Tau deubiquitination, impairing Tau degradation, dependent on its catalytically active cysteine, but independent of its noncanonical pathway modulated by its N-terminal domain in primary neurons. Otub1 strongly increased AT8-positive Tau and oligomeric Tau forms and increased Tau-seeded Tau aggregation in primary neurons. Finally, we demonstrated that expression of Otub1 but not its catalytically inactive form induced pathological Tau forms after 2 months in Tau transgenic mice in vivo, including AT8-positive Tau and oligomeric Tau forms. Taken together, we here identified Otub1 as a Tau deubiquitinase in vitro and in vivo, involved in formation of pathological Tau forms, including small soluble oligomeric forms. Otub1 and particularly Otub1 inhibitors, currently under development for cancer therapies, may therefore yield interesting novel therapeutic avenues for Tauopathies and AD.