Source document: https://docs-lawep.s3.us-east-2.amazonaws.com/1697724369554.pdf (Canada)
STRATEGIES TO OPTIMIZE ORGAN AND TISSUE DONATION AND TRANSPLANTATION Publication No.

2020-29-E 2 February 2022 Revised by Sonya Norris Parliamentary Information, Education and Research Services AUTHORSHIP Date Author Division 2 February 2022 Sonya Norris Legal and Social Affairs Division 1 April 2020 Sonya Norris Legal and Social Affairs Division ABOUT THIS PUBLICATION Library of Parliament HillStudies provide in-depth studies of policy issues.
They feature historical background, current information and references, and often anticipate the emergence of the issues they examine.

They are prepared by Parliamentary Information, Education and Research Services, which carries out research for and provides information and analysis to parliamentarians and Senate and House of Commons committees and parliamentary associations in an objective, impartial manner.
This publication was prepared as part of the Library of Parliament’s research publications program, which includes a set of publications, introduced in March 2020, addressing the COVID-19 pandemic.

© Library of Parliament, Ottawa, Canada, 2022 Strategies to Optimize Organ and Tissue Donation and Transplantation (HillStudies) Publication No.

2020-29-E Ce document est également publié en français.
CONTENTS EXECUTIVE SUMMARY 1 2 3 INTRODUCTION ..................................................................................................................... 1 FEDERAL, PROVINCIAL AND TERRITORIAL RESPONSIBILITY FOR ORGAN AND TISSUE DONATION AND TRANSPLANTATION .................................... 1 INITIATIVES AND POLICIES INTENDED TO INCREASE THE SUPPLY OF DONATED ORGANS AND TISSUES ........................................................ 3 3.1 3.1.1 3.1.2 Registries ................................................................................................................................ 3 Databases of Intended Donors................................................................................................ 4 Living Tissue Donor Registry .................................................................................................. 5 3.2 3.3 3.4 3.5 3.6 3.7 4 Cord Blood Bank ..................................................................................................................... 6 Presumed Consent ................................................................................................................. 6 Mandatory Declaration ............................................................................................................ 9 Mandatory Referral ................................................................................................................. 9 Professional Training in Donor Recruitment
 ............................................................................ 9 Public Awareness .................................................................................................................. 10 INITIATIVES INTENDED TO OPTIMIZE THE MATCHING OF AVAILABLE ORGANS AND TISSUES WITH INDIVIDUALS ON WAITING LISTS ............................................................................ 10 4.1 4.1.1 4.1.2 4.1.3 National Real-Time Waiting Lists for Patients Requiring Transplants ........................................................................................ 10 Kidney Paired Donation Program .......................................................................................... 11 National Organ Waitlist ......................................................................................................... 11 Highly Sensitized Patient Program ........................................................................................ 12 5 CONCLUSION ...................................................................................................................... 12 i EXECUTIVE SUMMARY The deceased organ donor rate in Canada is lower than that of top-performing countries, but Canada’s rate has improved in recent years.
Although the gap between the number of Canadians awaiting organ transplants and the number of organs available has narrowed, further increases in organ donation will be necessary to meet demand.

Initiatives to improve the organ donation and transplantation system include organ and tissue donor registries, national wait lists of patients, and the collection and storage of cord blood rich in stem cells.
Another initiative that may help to optimize the deceased organ donor rate is presumed consent, which Nova Scotia implemented in 2021, whereby all individuals are considered for organ donation after death unless they register their refusal during their lifetime.

In terms of consent, the issue of mandatory declaration has been considered by a number of jurisdictions.
Under this model, all individuals are required to register either their consent or refusal for organ donation, which differs from a passive approach of allowing a means of registering consent but not requiring it.

Consent to donate is of little value if potential donors are not properly identified and referred to specially trained donation specialists.
Mandatory referral, which requires that hospital personnel identify and refer potential donors to donation programs, could play a part in optimization efforts.

To be successful, this involves training organ donor coordinators to identify potential donors and specially trained physicians to optimize donation practices.

Public awareness campaigns may contribute to improving deceased and living organ and tissue donor rates.
In this regard, Canada’s National Organ and Tissue Donation Awareness Week, organized by Canadian Blood Services, takes place during the last full week of April every year.

Finally, a number of initiatives have been established to optimize the matching of donor organs and recipients in Canada.

These include the Kidney Paired Donation Program, the National Organ Waitlist and the Highly Sensitized Patient Program.
ii STRATEGIES TO OPTIMIZE ORGAN AND TISSUE DONATION AND TRANSPLANTATION ∗ 1 INTRODUCTION The number of transplant procedures performed in Canada increased by 42% between 2010 and 2019.

In 2019, 3,014 transplant procedures were performed, resulting in 3,084 organs being transplanted.1 However, the COVID-19 pandemic resulted in decreased organ donation and transplantation.

In 2020, deceased organ donations and organ transplants dropped by 12% and 14% respectively, compared to the previous year.
Despite the decline, the number of organs donated and transplants performed have increased over the past decade.2 While the number of donated organs from living donors has remained largely unchanged since 2011 (except in 2020), the deceased organ donor rate has risen 28%.

Despite the increase in available organs for transplant, the number of Canadians in need of an organ continues to be greater than the number of organs available.
In 2020 there were 4,247 people on the waiting list, and 196 of those people died before a suitable organ became available for them.3 This paper provides an overview of the jurisdictional considerations in organ and tissue donation and transplantation, and it lists the related federal and provincial/territorial legislation.
It goes on to describe several strategies that can increase the number of organs and tissues available for donation and that improve procedures for matching available organs with people on the waiting list.
It is a companion to the Library of Parliament publication by the same author, entitled Organ Donation and Transplantation in Canada: Statistics, Trends and International Comparisons.4 2 FEDERAL, PROVINCIAL AND TERRITORIAL RESPONSIBILITY FOR ORGAN AND TISSUE DONATION AND TRANSPLANTATION The provinces and territories are responsible for delivering health care to the majority of Canadians,5 including almost all aspects of organ and tissue donation and transplantation.
The exception to this responsibility is the safety of organs and tissues donated for transplant, which falls within federal jurisdiction.

In this regard, federal regulations pursuant to the Food and Drugs Act for organ and tissue donation and transplantation came into effect in December 2007.

The purpose of the regulations is to minimize the potential health risks to transplant recipients resulting from transplantation.
The Safety of Human Cells, Tissues and Organs for Transplantation Regulations standardize the screening and testing of potential donors in Canada.6 In addition, the federal government may collaborate with the provinces and territories and interested stakeholders to optimize existing programs.
To that end, in 2018, 1 STRATEGIES TO OPTIMIZE ORGAN AND TISSUE DONATION AND TRANSPLANTATION Health Canada created the Organ Donation and Transplantation Collaborative (the Collaborative), which includes provincial and territorial governments (except Quebec), Canadian Blood Services (CBS), patients, families, clinicians and researchers.
Activities of the Collaborative include: • creating a pan-Canadian data system that will support decisions, avoid missed opportunities and improve patient care; • identifying decision-making and accountability mechanisms to ensure that Canadians have access to an organ donation and transplantation system that responds to their needs and those of their families; • maximizing donor identification in hospitals and referrals to transplantation services across Canada; • • • • identifying underserved populations and improving patients’ access to post-transplantation care in remote communities; improving the efficiency and effectiveness of organ sharing processes across jurisdictions to prevent any missed opportunities for donation; increasing living donation as a preferred treatment option (e.g., kidneys, liver); and supporting health care professionals through professional education.7 Budget 2019 proposed $36.5 million over five years and $5 million annually of ongoing funding to allow the Collaborative to develop the above-mentioned pan-Canadian data and reporting system.8 The Canadian Institute for Health Information (CIHI), which has been responsible for collecting and publishing this data in its Canadian Organ Replacement Register (CORR), and Canada Health Infoway have been tasked with developing the new system.
CIHI reported in April 2021 on the specifics required for collecting, managing and reporting organ donation and transplantation data.9 The Collaborative expects to complete the implementation of this system by 2024.10 All provinces and territories in Canada have legislation on organ and tissue donation.

These statutes are set out in Table 1.


2 STRATEGIES TO OPTIMIZE ORGAN AND TISSUE DONATION AND TRANSPLANTATION Table 1 – Provincial/Territorial Legislation on Organ and Tissue Donation Jurisdiction British Columbia Alberta Saskatchewan Manitoba Ontario Quebec New Brunswick Legislation Human Tissue Gift Act, R.S.B.C.
1996, c. 211 Human Tissue and Organ Donation Act, S.A. 2006, c. H-14.15 The Human Tissue Gift Act, 2015, S.S. 2015, c. H-15.1 The Human Tissue Gift Act, C.C.S.M., c. H180 Gift of Life Act, R.S.O.

1990, c. H.20 Civil Code of Québec, CQLR, c. CCQ-1991 arts.

22, 25, 43, 44 and 45 Human Tissue Gift Act, R.S.N.B.

2014, c. 113 Prince Edward Island Human Tissue Donation Act, R.S.P.E.I.

1988, c. H-12.1 Nova Scotia Human Organ and Tissue Donation Act S.N.S.
2019, c. 6 Newfoundland and Labrador Yukon Human Tissue Act, R.S.N.L.

1990, c. H-15 Human Tissue Gift Act, R.S.Y.

2002, c. 117 Northwest Territories Human Tissue Donation Act, S.N.W.T.

2014, c. 30 Nunavut Human Tissue Act, R.S.N.W.T.

(Nu) 1988, c. H-6 (CanLII) Year 1996 2006 2015 1987 1990 1991 2014 2011 2019 1990 2002 2014 2011 Comments – In March 2020, amendments to the Act came into force.

The original version passed in 1978.

– – – – The 1993 version was the Human Tissue Gift Act.
The presumed consent system was implemented in January 2021.

– – – Nunavut adopted the legislation of the Northwest Territories.

Subsequent amendments contained in S.Nu.

2017, c. 22, s. 8 were not available online at the time of writing.

Source: Table prepared by the Library of Parliament using information obtained from provincial and territorial statutes in force at the time of writing.
3 INITIATIVES AND POLICIES INTENDED TO INCREASE THE SUPPLY OF DONATED ORGANS AND TISSUES 3.1 REGISTRIES A national registry containing information about donors and recipients can help authorities to identify who is willing to provide an organ and who requires one.
While a registry or database of intended donors can be helpful in identifying greater numbers of donors (described in section 3.1.1), a database of individuals awaiting an organ can help to improve efficiency in identifying compatible transplant recipients.

3 STRATEGIES TO OPTIMIZE ORGAN AND TISSUE DONATION AND TRANSPLANTATION Canada’s situation with respect to a national organ recipient waiting list is discussed in section 4 of this paper.
Some factors may affect the usefulness of a donor registry that helps to identify individuals who have expressed their intention to donate their organs should they become candidates.

These factors include the efficiency of coordinators in recruiting candidate donors who are registered, the administrative burden of maintaining and updating the registry, and the role of family consent.

Another limiting factor for both donor and waiting list registries is geography.
The viability of retrieved organs is measured in hours, and the faster an organ can be transplanted, the better the chances are for a successful outcome.

For example, transplantation should occur within 12 hours for a liver, 8 hours for a lung and 6 hours for a heart.11 The time constraint limits recipient possibilities in a large country like Canada.

Such a constraint does not apply in most other countries.
3.1.1 Databases of Intended Donors Also referred to as a donor registry, a database of intended donors is what most people have in mind when they discuss a national registry.

It contains names or other identifying information of individuals who have registered their intent to donate one or more organs and tissues after death.

The registry can be set up to register consent to donate only or to register either consent or refusal to become a donor.
While there is no national database of intended organ donors in Canada, all provinces and territories, usually under their respective organ and tissue donation legislation, provide some means of registering intent to donate.

These are listed in Table 2 below.


Table 2 – Provincial/Territorial Organ Donation Registries Jurisdiction British Columbia Alberta Saskatchewan Manitoba Ontario Quebec Description BC Transplant’s Organ Donor Registry allows residents to register their intent or refusal to become donors online, by mail or in person.

The Alberta Organ and Tissue Donation Registry permits residents to register, edit and update their consent to donate online.
The Saskatchewan Organ and Tissue Donor Registry allows residents to register the intent to donate online, by email or by mail.

Through Shared Health Manitoba’s SignUpforLife.ca, residents can register to be a donor, as well as check on and update their consent to donate, online.

The Trillium Gift of Life Network operates Ontario’s organ and tissue donor registry.

Residents can register, check on and update their consent to donate online or in person at ServiceOntario locations.
There are three ways to register consent to donate in Quebec.

First, Quebec’s Régie de l’assurance maladie du Québec operates a donor registry in which residents can register their intent to donate online.

Second, intended donors can affix a signed sticker to their health cards.

Third, residents can contact the Chambre des notaires du Québec to register consent or refusal to become a donor.
4 STRATEGIES TO OPTIMIZE ORGAN AND TISSUE DONATION AND TRANSPLANTATION Jurisdiction New Brunswick Description There is no online organ donor registry in New Brunswick.

Instead, residents can indicate their desire to become donors when they update or renew their provincial health insurance cards.

Prince Edward Island Residents may register their intent to donate online or by completing a form and submitting it to the Prince Edward Island Medicare Office.
Nova Scotia Newfoundland and Labrador Yukon Under presumed consent effective January 2021, residents can register their consent or refusal to donate when they renew their health cards or by completing a mail-in form.

There is no online registry in the province, but residents can indicate and update their intent to donate on Medical Care Plan applications for health coverage.
When residents apply for health coverage, they can indicate their intent to donate and the words “organ donor” will appear on their newly issued health cards.

Residents can complete a form and submit it to the territorial health insurance office to register their intent to donate.

In addition to being added to the registry, intended donors receive a sticker to put on their health cards.
Northwest Territories and Nunavut Residents who wish to register their intent to donate can do so through Alberta’s Organ and Tissue Donation Registry.
Sources: Table prepared by the Library of Parliament using information obtained from British Columbia, Provincial Health Services Authority, BC Transplant, Organ Donor Registry; Alberta, MyHealth.Alberta.ca, Alberta Organ and Tissue Donation Registry; Saskatchewan, Saskatchewan Health Authority, Organ and Tissue Donor Registry; Manitoba, Shared Health Manitoba, SignUpForLife.ca; Ontario, Ontario Health, Trillium Gift of Life Network, beadonor.ca; Quebec, Ministry of Health, Organ and tissue donation; New Brunswick, Department of Health, New Brunswick Organ & Tissue Donation Program; Prince Edward Island, Department of Health and Wellness, Register as an Organ and/or Tissue Donor; Nova Scotia, Programs and Services, Organ and tissue donation; Newfoundland and Labrador, Eastern Health, Organ Donation; Yukon, Health and Wellness, Donate your organs; and Northwest Territories, Health and Social Services, Organ and Tissue Donation.
A national donor registry could be created through the voluntary participation of the provinces and territories by combining their respective databases into a single registry.

Another proposed approach to the matter is to allow the Canada Revenue Agency to collect information on donor intent on federal income tax forms and to pass the information on to the relevant provincial or territorial government.
This mechanism, proposed during the 43rd Parliament in a private member’s bill, Bill C-210, was passed and received Royal Assent in June 2021.12 The new legislation does not stipulate a timeline for the Canada Revenue Agency to begin collecting the information.

3.1.2 Living Tissue Donor Registry The CBS Stem Cell Registry13 is a registry of potential live donors of bone marrow or circulating peripheral blood (both sources of stem cells) for all provinces except Quebec.
In Quebec, Héma-Québec operates the Stem Cell Donor Registry.14 Both registries are part of the World Marrow Donor Association, which provides access to about 40 million potential donors around the world.15 5 STRATEGIES TO OPTIMIZE ORGAN AND TISSUE DONATION AND TRANSPLANTATION 3.2 CORD BLOOD BANK Umbilical cord blood is a rich source of stem cells, which are used in the treatment of blood disorders such as aplastic anemia and leukemia.
Stem cell transplants from cord blood result in less tissue rejection than stem cell transplants from other sources.

CBS launched a publicly funded umbilical cord blood bank in 2015, with the participation of all provinces except Quebec.
The CBS Cord Blood Bank provides multiple collection and storage facilities across Canada.16 In Quebec, Héma-Québec has created its own public cord blood bank.17 3.3 PRESUMED CONSENT An option often suggested as a way to increase organ donor rates is the presumed consent system, also known as deemed consent or the opt-out system.

Under this approach, consent to donate is presumed unless a person has expressly indicated otherwise during their lifetime.
Until recently, all provinces and territories in Canada have operated under the opt-in, explicit consent or required consent system, whereby an individual expresses the intention to become a donor.

Consent to donate is addressed in the provincial and territorial statutes pertaining to organ and tissue donation.

Under explicit consent, failure to express a desire to donate during one’s lifetime is not considered a refusal to become a donor; rather, the family becomes the ultimate source for consent.
Proponents of the presumed consent approach note that the vast majority of Canadians are in favour of organ donation when asked, but that only a fraction of those who are in favour actually register their intent in a database or through their health cards.18 Many countries have adopted the presumed consent approach, and proponents of this approach note that the majority of countries with the highest deceased donor rates worldwide have presumed consent legislation (see Figure 1).19 In 2021, Nova Scotia became the first province in Canada to implement presumed consent for organ and tissue donation.
The new legislation still requires consent from the next of kin, and it also implements a mandatory referral system, described in section 3.5 of this paper.20 Some other provinces, including Alberta, Ontario and Quebec, have also seen private members’ bills that propose presumed consent for organ donation; however, none have become law.
British Columbia, however, asserts that other strategies, including some described later in this document, are more effective at increasing the deceased donor rate than presumed consent.21 6 STRATEGIES TO OPTIMIZE ORGAN AND TISSUE DONATION AND TRANSPLANTATION Figure 1 – Deceased Organ Donor Rates and Consent Regimes in Selected Countries, 2020 (per million population) Note: a.

With the exception of Wales, explicit consent to donate organs was previously required in the United Kingdom.
England and Scotland have implemented presumed consent systems, but the data illustrated here predate those introductions.

In Canada, presumed consent in Nova Scotia had not yet been implemented for this data period.
Source: Figure prepared by the Library of Parliament using data obtained from International Registry in Organ Donation and Transplantation, “Worldwide Actual Deceased Organ Donors Rate 2020 (pmp),” International Registry in Organ Donation and Transplantation: Final numbers 2020, December 2021, p. 2; and Canadian Institute for Health Information, Annual statistics on organ replacement in Canada, 2011 to 2020.
7 STRATEGIES TO OPTIMIZE ORGAN AND TISSUE DONATION AND TRANSPLANTATION However, Figure 1 reveals that the consent regime is not the only variable that determines deceased organ donor rate.

Some countries with presumed consent regimes have donor rates that are lower than other countries that operate opt-in systems.

For example, Poland and Sweden, which both have presumed consent legislation, report lower donor rates than Canada under its opt-in approach.
Moreover, the United States (U.S.), which has an opt-in system, has the highest deceased donor rates.
A 2009 review of studies that compared donation rates before and after the introduction of presumed consent legislation in three countries found that presumed consent “is associated with increased organ donation rates, even when other factors are 22 The review’s authors noted, however, that there was little examination accounted for.” in the studies of any other changes taking place when the legislation was introduced, and that other factors, such as the availability of donors, the infrastructure of the transplantation service, investment in health care and public attitudes toward organ donation may all have played a role in determining donor rates.
More recently, a similar conclusion was drawn by the authors of a 2019 study that compared six countries that had changed from an explicit system to a presumed consent regime.
The authors concluded that [a]lthough presumed consent alone is unlikely to explain the increase in donation rates, the adoption of such a policy may prove to be a worthwhile risk for countries experiencing consistently low organ donation rates.23 Analyses of organ donor rates in Spain and Brazil suggest that it was not the introduction of presumed consent legislation per se that brought about an increase in organ donor rates, but rather an increased investment in donation and transplantation infrastructure.
Spain, which has had the highest organ donor rate worldwide for several years, did not realize an improvement in the organ donor rate, despite its presumed consent system, until the country invested in the organizational structure for organ donation.24 Brazil abolished its presumed consent law shortly after implementing presumed consent in the late 1990s, when it realized that without the added infrastructure, presumed consent would not produce additional organ donors.25 Other countries have taken different approaches to rendering presumed consent more effective.
Singapore, Israel and Chile, for example, have implemented policies whereby individuals who opt out as potential organ donors under their presumed consent systems are given lower priority should they need an organ transplant.26 8 STRATEGIES TO OPTIMIZE ORGAN AND TISSUE DONATION AND TRANSPLANTATION It has been reported that few countries that have presumed consent legislation actually enforce it.27 Rather, these jurisdictions have brought about improved organ donor rates by addressing family consent and donor identification and recruitment.28 Public awareness campaigns that reinforce the need to voice one’s intentions to family, as well as professional awareness and training programs that ensure donor identification and recruitment occur under a specific set of guidelines and policies, are some of the initiatives put in place by high-performing countries to improve organ donor rates.
A 2012 article about the deceased donation process in 29 countries where explicit consent must be given and 25 countries operating presumed consent systems observed that: deceased donation programs are complex, affected not only by law, administration and infrastructure but also ideology and values.
It is improbable that any single strategy or approach will cause a marked improvement on deceased donation rates.29 The article contended that the authority of the next of kin must be factored into any decision to implement presumed consent.

3.4 MANDATORY DECLARATION Although not implemented anywhere in Canada, mandatory declaration (sometimes referred to as “mandated choice”) ties consent for organ donation to a regulated program, usually provincial health care coverage, for which every resident applies.
This approach requires that, as part of the application process, individuals declare whether or not they consent to organ donation following death.

3.5 MANDATORY REFERRAL Mandatory referral (or required reporting) is the requirement that health care professionals report all brain deaths (and possibly cardiac deaths) or imminent deaths to their local organ procurement organization.
With the exception of Saskatchewan and Newfoundland and Labrador, as of 2018 all provinces that have an organ donation and transplantation program have implemented or are implementing some sort of mandatory referral system in an effort to boost organ and tissue donor rates.30 3.6 PROFESSIONAL TRAINING IN DONOR RECRUITMENT In the past, health care professionals were not given specific training for recruiting organ donors.
As a result, they may have felt reluctant to approach the families of potential donors and may not have been adequately informed about organ referral.

Over the years, as organ donation and transplantation programs have evolved, specially trained organ donor coordinators and physicians have joined these programs.

The 9 STRATEGIES TO OPTIMIZE ORGAN AND TISSUE DONATION AND TRANSPLANTATION coordinators are trained to identify potential donors and approach families for consent.
The organ donor physicians are trained to improve donation practices, support donor care, and facilitate education and awareness, all in collaboration with the coordinators and the health care facility.
All provinces with an organ donation and transplantation program have implemented or are in the process of implementing donation physician programs.31 CBS has described the inclusion of donation physicians as the “cornerstone” of Spain’s successful organ donation and transplantation program.32 3.7 PUBLIC AWARENESS Public awareness campaigns about organ donation and transplantation help individuals to make an informed choice about their intent or refusal to donate their organs.
As well, the campaigns help to increase public support for and participation in the donation and transplantation process.
In 1997, Parliament enacted the National Organ Donor Week Act, which established the last full week of April of each year as National Organ Donor Week.33 Since assuming responsibility for organ and tissue donation in 2008, CBS coordinates activities during what is now called the National Organ and Tissue Donation Awareness Week, together with provincial organizations, health charities and advocacy groups, to raise awareness and encourage Canadians to register their intent to donate organs either after their death or as a living donor.34 4 INITIATIVES INTENDED TO OPTIMIZE THE MATCHING OF AVAILABLE ORGANS AND TISSUES WITH INDIVIDUALS ON WAITING LISTS 4.1 NATIONAL REAL-TIME WAITING LISTS FOR PATIENTS REQUIRING TRANSPLANTS Proponents of real-time waiting lists sometimes point to the registry operated in the U.S. as an example to follow.
The U.S. has implemented a system to manage the logistical issues associated with operating a national approach to organ donation and transplantation.

The U.S.
The U.S.

Organ Procurement and Transplantation Network (OPTN) links all professionals involved in the donation and transplant system by maintaining a national waiting list (operated by a private organization called the United Network 35 for Organ Sharing, or UNOS) and providing “equity in access to transplants.” All U.S. transplant centres and organ procurement organizations are members of the OPTN.
When an organ donor has been identified and consent obtained in the U.S., the procuring organization accesses the national transplant database operated by the OPTN, either online or by contacting the UNOS Organ Center directly.

Once donor information 10 STRATEGIES TO OPTIMIZE ORGAN AND TISSUE DONATION AND TRANSPLANTATION is entered, a donor–recipient search for a match is run for each donated organ.
The resulting list of potential recipients is ranked according to objective medical criteria (e.g., blood type, tissue type and size of the organ, as well as the medical urgency of the patient’s situation, the time already spent on the waiting list and the distance between donor and recipient).

Each organ has specific criteria.


Using the list of potential recipients, the local organ procurement coordinator or an organ placement specialist contacts the transplant centre of the highest-ranked patient and offers the organ.

If the organ is turned down, the organ procurement coordinator or placement specialist contacts the transplant centre of the next highest-ranked potential recipient on the match list, and this is repeated until a recipient is found.
Once the organ is accepted for a patient, UNOS assists with the transportation arrangements, and the transplant surgery is scheduled.36 Canada does not have a single, centralized list of all patients waiting for an organ.

However, since accepting responsibility for Canada’s organ and tissue donation and transplantation system in 2008, CBS has developed the Canadian Transplant Registry with the participation of all jurisdictions, including Quebec.
It consists of three national patient registries, described below.

4.1.1 Kidney Paired Donation Program In 2009, CBS announced the first kidney transplants performed through the Living Donor Paired Exchange, the first registry of its kind in Canada.

In 2014, the program was renamed the Kidney Paired Donation (KPD) Program.

The KPD, which is both a donor registry and a recipient registry, aims to optimize the use of kidneys from living donors.
If an individual is willing to donate a kidney to a designated recipient, such as a family member or friend, but is not a match for that recipient, the donor may register and possibly be a match for another recipient.

The KPD registers pairs of individuals: a donor willing to donate a kidney and a recipient in need of a kidney but who are not a match.

However, matches can be made with another donor/recipient pair where tissue type and blood group make such swapping possible.
Matching donors to recipients can sometimes involve multiple pairs.

As of 1 January 2022, the KPD Program had facilitated 872 kidney transplants.37 4.1.2 National Organ Waitlist The National Organ Waitlist (NOW) was launched in 2012 by CBS.

NOW is a real-time, online listing of Canadians awaiting transplants for all organs except kidneys (heart, lung, liver, pancreas and bowel, or multiple organs).
Provincial and territorial donation and transplantation programs can access the secure database to identify patients in the most critical need anywhere in Canada.
NOW alerts are also sent regularly to health care subscribers to provide information about wait times and organ availability.38 11 STRATEGIES TO OPTIMIZE ORGAN AND TISSUE DONATION AND TRANSPLANTATION 4.1.3 Highly Sensitized Patient Program CBS established the Highly Sensitized Patient (HSP) Program in 2013, in cooperation with provincial transplant programs, to provide kidneys for donation to patients whose immune systems are highly sensitized.
It provides a registry for kidney transplant candidates who are difficult to match given their immunological profile and includes efforts to help find donors for these highly sensitized patients through national sharing.

As of 1 February 2022, the HSP Program had facilitated 759 kidney transplants.39 5 CONCLUSION Canada has a long waiting list of individuals in need of a transplant.

Various strategies could be deployed to increase the number of organs available and optimize outcomes in transplantation.
The majority of countries with the highest deceased organ donor rates also have presumed consent regimes, although some countries with presumed consent regimes have low donor rates.

The introduction of such regimes is controversial, and debate continues as to whether presumed consent regimes alone can increase organ donor rates.
Initiatives, such as improving the training of personnel for identification and follow-up of potential donors in hospitals, requiring individuals to register their intent or refusal to donate, and holding ongoing public awareness campaigns, are solutions that have been proposed to boost organ donor rates and increase the number of successful organ transplants.

NOTES ∗ 1.

2.

3.

4.

5.

6.

7.

8.

9.


This HillStudy is based on an earlier publication by the same author: Sonya Norris, Organ Donation and Transplantation in Canada, Publication no.

2018-13-E, Library of Parliament, 14 February 2018.

Canadian Institute for Health Information (CIHI), “Annual Statistics on Organ Replacement in Canada: Dialysis, Transplantation and Donation, 2010 to 2019,” CIHI Snapshot, December 2020.

CIHI, Annual Statistics on Organ Replacement in Canada, 2011 to 2020.
CIHI, e-Statistics Report on Transplant, Waiting List and Donor Statistics, 2020.

Sonya Norris, Organ Donation and Transplantation in Canada: Statistics, Trends and International Comparisons, Publication no.

2020-28-E, Library of Parliament, 1 April 2020.

For more information on the federal and provincial responsibilities in health care, see Martha Butler and Marlisa Tiedemann, The Federal Role in Health and Health Care, Publication no.

2011-91-E, Library of Parliament, 20 September 2013.
Safety of Human Cells, Tissues and Organs for Transplantation Regulations, SOR/2007-118.

For more background information, see Government of Canada, Cells, Tissues and Organs.

Government of Canada, Organ donation and transplantation collaborative.

Department of Finance Canada, Investing in the Middle Class, Budget 2019, p. 154.

CIHI, Pan-Canadian Organ Donation and Transplantation Data and Performance Reporting System: Indicators and Measures Short-List for Prioritization, April 2021.
12 STRATEGIES TO OPTIMIZE ORGAN AND TISSUE DONATION AND TRANSPLANTATION Organ Donation and Transplantation Collaborative, “Implementation of a Pan-Canadian Data Management and Performance Reporting Data System,” Project Snapshot.

Nicoletta Lanese, “How Long Can Organs Stay Outside the Body Before Being Transplanted?,” Live Science, 28 December 2019.
Bill C-210, An Act to amend the Canada Revenue Agency Act (organ and tissue donors), 43rd Parliament, 2nd Session (S.C. 2021, c. 12).

Canadian Blood Services (CBS), Stem Cells for Life.

Héma-Québec, “Stem Cell Donors,” Stem Cells.

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17, No.

6, June 2017.

Amanda M. Rosenblum et al., “The authority of next-of-kin in explicit and presumed consent systems for deceased organ donation: an analysis of 54 nations,” Nephrology Dialysis Transplantation, Vol.

27, No.

6, June 2012.

CBS, Organ and Tissue Donation and Transplantation: System Progress Report 2018, 2019, p. 12.

Ibid.
Ibid.

CBS, Organ Donation and Transplantation in Canada: System Progress Report 2006–2015, 2016, p. 55.

National Organ Donor Week Act, S.C. 1997, c. 4.

CBS, Backgrounder: National Organ and Tissue Donation Awareness Week.

United States (U.S.), Department of Health and Human Services, Health Resources and Services Administration, “Vision & goals,” Organ Procurement and Transplantation Network.
U.S., Department of Health and Human Services, Health Resources and Services Administration, “Donor matching system,” Organ Procurement and Transplantation Network.

CBS, Kidney Paired Donation (KPD) Program.

CBS, National Organ Waitlist (NOW).

CBS, Highly Sensitized Patient (HSP) Program.

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