Patent ID: 9572899
Date: 2017-02-21
CPC Classifications: A61K,C12N

Claim:
1. A peptide-nucleic acid analog conjugate comprising: i) a carrier peptide consisting of from ten to fifteen subunits connected by amide bonds, wherein each subunit is selected from X and Y subunits, including from eight to thirteen X subunits and from two to four contiguous Y subunits; ii) a nucleic acid analog comprising a substantially uncharged backbone and a targeting base sequence; and iii) a linker consisting of one or more linker subunits connected by amide bonds, and optionally a piperazine moiety; and iv) a covalent attachment between the nucleic acid analog and the carrier peptide, the covalent attachment consisting of amide bonds to the linker, wherein: (a) each X subunit is independently an amino acid subunit comprising a side chain of the structure R (b) each Y subunit is independently a hydrophobic amino acid comprising a substituted or unsubstituted alkyl, alkenyl, alkynyl, aryl or aralkyl side chain, wherein the alkyl, alkenyl or alkynyl side chain includes at most one heteroatom for every six carbon atoms; and (c) each linker subunit is of the formula —C(O)—(CH