Patent ID: 9569566
Date: 2017-02-14
CPC Classifications: A61M,G06F,G16B,G16H

Claim:
1. A system for simulating an in vivo cellular interaction in a simulated therapy zone and measuring sensed simulated cellular response characteristics for output via an operator interface, which system comprises: a medium material including a characteristic simulating an in vivo characteristic, said medium material including an interior forming said simulated therapy zone and an outer surface; a container enclosing said medium material outer surface and configured for receiving and containing said medium material; said container including external constraints configured to mimic in vivo conditions and for application to said medium material; an energy source adapted for exerting a pressure gradient via simulation onto the cell and measuring a response of the cell to the simulated pressure gradient; a simulated cell manipulating factor source connected to the medium material and the energy source; said simulated cell manipulating factor source being chosen from the group comprising: fluid pressure gradient; a pressure differential manifold in the simulated therapy zone; an inflow line fluidically connecting the factor source to the pressure differential manifold; an outflow line from the pressure differential manifold; a fluid source connected to the therapy zone via the inflow line; a pump connected to the factor source and the inflow line; a controller connected to the pump and programmed for controlling the operation of the pump in response to simulated therapy zone conditions; said manifold comprising a fluid-permeable foam material and manifold tubing fluidically connected to said foam material; said controller applying a pulse wave in said simulated therapy zone with a simulated in vivo pressure differential chosen from among the group comprising circulatory, lymphatic or respiratory; a pressure force sensor embedded in said medium material and adapted for sensing a pressure force effect including fluid pressure source amplitude and frequency therein; an output connected to said pressure force sensor and adapted for providing output corresponding to said sensed pressure force effect and including amplitude and frequency of pressure waves in said medium material; wherein said medium material comprises a synthetic gel; and wherein said synthetic gel comprises a synthetic material with soft-tissue characteristics.