Patent ID: 9550808
Date: 2017-01-24
CPC Classifications: A61K,A61P,A61Q,C07K

Claim:
1. A cosmetic composition for smoothing facial and age-related wrinkles, comprising a compound of the general formula (I): X1-X2-X2-Pro-X4-Pro-X5 (SEQ ID NO:54), wherein: X1 is selected from the group consisting of H—, Ac—, and Palm-; X2 is selected from the group consisting of Trp, and Tyr; X3 is selected from the group consisting of Trp, and Tyr; X4 is selected from the group consisting of Lys, Orn, Dbu, Dpr, and Arg; and X5 is selected from the group consisting of —OH, —NH or a cosmetically acceptable retro-isomer and/or salt thereof; wherein the compound is present in an amount effective to selectively block muscle-type nicotinic acetylcholine receptors and suitable for smoothing facial and age-related wrinkles; and wherein the cosmetic composition is in the form of a lotion, balm, cream, gel, gel forming polymers, spray, or face mask.