Patent ID: 9664698
Date: 2017-05-30
CPC Classifications: A61B,A61P,G01N,G16H,Y02A

Claim:
1. A method of detecting a lipid in a subject, comprising: (a) assaying a sample from said subject to determine the concentration of one or more lipids wherein the one or more lipids is selected from: 12-HETE, 15-HETE, 13-HODE, PE P-18:0/20:4, PE O-18:1/20:4, LacCer(d18:1/22:0), LacCer(d18:1/20:0), PE 18:0/20:4, Cer(d18:1/18:0), LacCer(d18:1/24:0), Cer(d18:1/20:0), PC16:0/20:3, AA, Cer(d18:1/24:1), Cer(d18:1/26:1), Glc/GalCer(d18:1/24:1), Cer(d18:1/22:0), Glc/GalCer(d18:1/18:0), Cer(d18:1/16:0), LacCer(d18:1/24:1), SM(d18:1/14:0)(d18:1/13:1-OH), LacCer(d18:1/16:0), CE 18:3, PC 16:0/20:4, 11_12-DHET, 14_15-DHET, 5-HETrE, 5-HETE and 8_9-DHET; or (b) assaying a sample from said subject to determine the concentration of one or more lipid-lipid concentration ratios, wherein the one or more lipid-lipid concentration ratios is selected from: 12-HETE/5-HETrE, 12-HETE/8_9-DHET, 12-HETE/5-HETE, 12-HETE/14_15-DHET, 12-HETE/CE 20:4, 12-HETE/15-HETrE, 12-HETE/LPC 16:0, 15-HETE/8_9-DHET, 12-HETE/5-HEPE, 12-HETE/PC 18:0/18:2, 12-HETE/CK, 15-HETE/5-HETE, 12-HETE/CE 18:3, 13-HODE/8_9-DHET, 15-HETE/15-HETrE, 11_12-DHET/CE 18:2, 14_15-DHET/CE 18:2, 11_12-DHET/LacCer(d18:1/24:0), 11_12-DHET/Cer(d18:1/16:0), 5-HETE/CE 20:4, 14_15-DHET/LacCer(d18:1/22:0), 14_15-DHET/Glc/GalCer(d18:1/18:0), 15-HETrE/LacCer(d18:1/22:0), 11_12-DHET/Cer(d18:1/20:0), 5-HETE/CE 18:2, 5-HETE/CE 18:1, 8_9-DHET/CE 18:2, 8_9-DHET/CE 18:1, 8_9-DHET/CE 22:6, 14_15-DHET/Cer(d18:1/18:0), 5-HETE/LacCer(d18:1/24:1), 8_9-DHET/CE 16:0, 5-HETE/Glc/GalCer(d18:1/18:0), 8_9-DHET/Cer(d18:1/26:0), 8_9-DHET/LacCer(d18:1/16:0), 5-HETE/9-HODE, 8_9-DHET/Cer(d18:1/16:0), 8_9-DHET/Cer(d18:1/26:1), 8_9-DHET/Glc/GalCer(d18:1/18:0), 11_12-DHET/12-HETE, 8_9-DHET/9-HODE, 5-HETE/Cer(d18:1/18:0), 8_9-DHET/AA, 5-HETE/PC 16:0/20:3, 8_9-DHET/Cer(d18:1/24:1), 8_9-DHET/CE 16:1, 11-HETE/12-HETE, 8_9-DHET/Cer(d18:1/20:0), 8_9-DHET/PC 16:0/20:3 and 8_9-DHET/Cer(d18:1/18:0), and wherein the subject is at an increased risk of developing statin-induced muscle toxicity or the subject is suffering from statin-induced muscle toxicity and/or one or more complications of statin-induced muscle toxicity, wherein the one or more complications are selected from myalgia, myositis, myopathy or rhabdomyolysis.