Patent ID: 9700514
Date: 2017-07-11
CPC Classifications: A61K

Claim:
1. A solid oral dosage form for the treatment of patients with at least one of Helicobacter pylori infection and duodenal ulcer disease; said solid oral dosage form consisting of a bismuth-free pharmaceutical formulation; said bismuth-free pharmaceutical formulation consisting of one enteric-coated proton pump inhibitor active pharmaceutical ingredient wherein the one enteric-coated proton pump inhibitor is optionally in the form of enteric-coated granules or enteric-coated pellets within same said oral dosage form; one histamine H2-receptor antagonist active pharmaceutical ingredient, or a combination thereof; said bismuth-free pharmaceutical formulation further consisting of at least one pharmaceutically acceptable excipient ingredient and at least two different antibiotic active pharmaceutical ingredients, wherein said at least two different antibiotic active pharmaceutical ingredients are selected from the group consisting of macrolide antibiotics and beta-lactam antibiotics and wherein at least one of said at least two different antibiotic active pharmaceutical ingredients is coated pellets independent from, and protected from contact or interacting with, at least one other antibiotic active pharmaceutical ingredient of said bismuth-free pharmaceutical formulation at least before oral administration of said solid oral dosage form and wherein the solid oral dosage form optionally further consists of at least one beta-lactamase inhibitor and optionally wherein all active pharmaceutical ingredients are protected from contact and interacting with each other within same solid oral dosage form.