Patent ID: 9580481
Date: 2017-02-28
CPC Classifications: A61K,A61P,C07K,C12N,Y02A

Claim:
1. An isolated protein comprising: a viral capsomere-forming amino acid sequence, wherein said viral capsomere-forming amino acid sequence comprises an amino acid sequence of a polyomavirus capsomere lacking at least part of the amino-terminus and/or the carboxy-terminus that is normally present in the amino acid sequence of the polyomavirus capsomere; and a heterologous immunogenic amino acid sequence at the amino-terminus of the polyomavirus capsomere amino acid sequence that is not a purification tag amino acid sequence and/or expression-enhancing tag amino acid sequence, wherein said isolated protein is essentially incapable of assembly into virus-like particles (VLPs) as a result of lacking VLP assembly-related parts of the viral capsomere-forming amino acid sequence and/or the addition of said immunogenic amino acid sequence at the amino-terminus of said viral capsomere-forming amino acid sequence, and thereby retains a capsomere morphology.