Patent ID: 9624548
Date: 2017-04-18
CPC Classifications: A61P,C12Q

Claim:
1. A method for identifying an increased chance of the presence of bladder cancer in a patient suspected of having bladder cancer, the method comprising: (a) determining an amount of a biomarker in a urine sample obtained from the patient by contacting the urine sample with an anti-EN2 antibody, or fragment thereof, that specifically binds to the biomarker; (b) comparing the amount of the biomarker in the urine sample obtained from the patient to the amount of the biomarker in a normal control; and (c) determining that there is an increased chance of the presence of bladder cancer in the patient if the level of the biomarker in the urine sample obtained from said patient is increased by at least about 200% relative to the level of the biomarker in the normal control; or determining that there is no increased chance of the presence of bladder cancer in the patient if the level of the biomarker in the urine sample obtained from said patient is not increased relative to the level of the biomarker in the normal control; wherein the biomarker comprises an amino acid sequence comprising SEQ ID NO:2 or an amino acid sequence that has at least 95% amino acid sequence identity with SEQ ID NO:2.