Patent ID: 9651554
Date: 2017-05-16
CPC Classifications: A61K,A61N,A61P,G01N,G16B,G16C,Y02A

Claim:
1. A method of treating brain metastasis of breast cancer in a human patient, the method comprising: assaying the mRNA levels of seven biomarkers in a primary breast cancer sample obtained from a patient having brain metastasis of breast cancer, wherein the seven biomarkers are selected from the group consisting of ret proto-oncogene (RET), proto-oncogene tyrosine-protein kinase Fyn (FYN), kinase insert domain receptor (KDR), RAF proto-oncogene serine/threonine-protein kinase (RAF1), NF-kappa-B p105 subunit (NFKB1), histone deacetylase 1 (HDAC1), and histone deacetylase 2 (HDAC2); determining that the mRNA level of RET, FYN, or KDR is higher than a corresponding control level in primary breast cancer samples obtained from control subjects without brain metastasis of breast cancer; and administering to the patient (i) Sunitinib when the mRNA level of RET or KDR is higher or, in the alternative, (ii) Dasatinib when the mRNA level of FYN is higher.