Patent ID: 9708394
Date: 2017-07-18
CPC Classifications: A61K,A61P,C07K,G01N

Claim:
1. An anti-C1q antibody, comprising; (a) a light chain variable domain and a heavy chain variable domain, wherein the light chain variable domain comprises the hypervariable region (HVR)-L1, HVR-L2, and HVR-L3 of the monoclonal antibody M1 produced by a hybridoma cell line with ATCC Accession Number PTA-120399; and wherein the heavy chain variable domain comprises the HVR-H1, HVR-H2, and HVR-H3 of the monoclonal antibody M1 produced by a hybridoma cell line with ATCC Accession Number PTA-120399; or (b) a heavy chain HVR selected from HVR-H1 comprising the amino acid sequence of SEQ ID NO: 9, HVR-H2 comprising the amino acid sequence of SEQ ID NO: 10, and HVR-H3 comprising the amino acid sequence of SEQ ID NO: 11.