Patent ID: 9738709
Date: 2017-08-22
CPC Classifications: A61K,A61P,C07K,G01N

Claim:
1. A method comprising: a. obtaining a test biological sample from an individual, the test biological sample being chosen from cerebrospinal fluid, blood, serum, and plasma; b. quantifying the amounts of a methylated tau protein in the test biological sample obtained in step a, said methylation occurring on one or more lysine residues, wherein said quantifying of said methylated tau protein is achieved via use of an antibody to a methylated peptide derived from tau protein; c. comparing the amounts of methylated tau protein in the test biological sample with the amounts present in a control biological sample from a subject without Alzheimer's disease; d. diagnosing Alzheimer's disease, or predisposition thereto, based on a difference in the amount of the methylated tau protein in the test biological sample as compared to the control biological sample; and e. administering to the individual a composition chosen from: