Patent ID: 9606101
Date: 2017-03-28
CPC Classifications: G01N,H01J

Claim:
1. A method of performing MALDI-TOF mass spectrometry on a sample, comprising the steps of: A) applying the sample to multiple predefined sample spots of a MALDI plate; B) raster scanning the multiple predefined sample spots of the MALDI plate with a laser in accordance with a raster file defining a pattern for raster scanning of a spot of a MALDI sample plate at a multitude of noncontiguous X-Y locations and acquiring mass spectra of the sample from each of the X-Y locations of the spots, wherein the raster scanning comprises directing a multitude of laser shots to each of the noncontiguous X-Y locations; C) after performing normalization and alignment operations, summing the mass spectra acquired in step B); wherein the sample is subject to a total of at least 100,000 laser shots in the raster scanning of the multiple predefined sample spots.