Patent ID: 9688655
Date: 2017-06-27
CPC Classifications: A61P,C07D

Claim:
1. A process for the preparation of compound (X) comprising  reacting a compound of formula (XI-c), wherein P is an amino protecting group, with compound (IV); in the presence of an amide coupling reagent; and in the presence of a catalyst; in an organic solvent; at a temperature in the range of from about 0° C. to about 50° C.; to yield the corresponding compound of formula (XII-c); or,  reacting compound (IV) with phosgene or a phosgene analog; in the presence of an organic base; in an aprotic solvent; then treating a resulting isocyanate intermediate (IVa), optionally without isolation, with a compound of formula (XI-c); in the presence of a non-nucleophilic base; at a temperature in the range of from about −20° C. to about 80° C.; to yield the corresponding compound of formula (XII-c);  reacting a compound of formula (XII-c) under amino deprotection conditions; in an organic solvent; at a temperature greater than ambient temperature; to yield the corresponding compound (XIII);  reacting compound (XIII) with a compound of formula (2c-1) wherein X is chloro, bromo, or iodo, and W is C  reacting a compound of formula (2c-2) to form compound (X).