Patent ID: 9682167
Date: 2017-06-20
CPC Classifications: A61F,A61K,A61L,A61P,C08B,C08J,C08L,Y10T

Claim:
1. A biologically compatible PEG/CMC gel composition being suitable for inhibiting formation or reformation of adhesions after surgery, for space filling, or for lubrication, comprising: a carboxymethyl cellulose (CMC) having an average molecular weight of about 700 kD (CMC-A) and a degree of substitution of about 0.65 to 0.85; and a polyethylene glycol di-epoxide (PEG diglycidyl ether (PEGDGE)) having a molecular weight between about 500 Daltons and about 8000 Daltons, said PEG linked to said CMC-A via an addition reaction of one of said epoxide moieties of said PEGDGE to a carboxyl or a hydroxyl moiety of one molecule of CMC-A, and the other of said epoxide moieties of said PEGDGE to a carboxyl or a hydroxyl moiety of another molecule of CMC-A in the presence of 0.01% citric acid, forming a cross-linked PEG/CMC-A gel composition having a carboxymethyl anhydroglucose unit (CMAG) to epoxide (EP) ratio of about 14.3, said gel composition having a pH of about 6.8, and being suitable for inhibiting formation or reformation of adhesions after surgery, for space filling, or for lubrication.