Patent ID: 9566351
Date: 2017-02-14
CPC Classifications: A61K

Claim:
1. A method for enhancing the therapeutic effect of a poorly water soluble drug in an individual in need of the therapeutic effect, wherein the poorly soluble drug has a solubility of less than 1.0 mM in water or an aqueous buffer, the method comprising administering to the individual a composition comprising the poorly water soluble drug and a compound having the following structure: or a salt, a partial salt, a hydrate, or a stereoisomer thereof, wherein each R is independently hydrogen, C wherein, optionally, adjacent R groups form a C wherein each is independently a C 5 to C 20 carbocyclic ring system or C 2 to C 20 heterocyclic ring system, wherein the ring system comprises one or more rings; wherein at least one ring system has at least one solubilizing group selected from sulfonic acid group, sulfonate salt group, phosphonic acid group, phosphonate salt group, and polyethylene glycol group; wherein, optionally, the ring system has a targeting group; and wherein n is 1 to 5.