Patent ID: 9656030
Date: 2017-05-23
CPC Classifications: A61B,A61F,A61M

Claim:
1. A method comprising: percutaneously positioning a delivery device in a coronary artery; and performing at least one cycle of injection and occlusion, wherein a single cycle of injection and occlusion comprises: locally introducing a treatment agent from the delivery device into the coronary artery upstream of at least one of an infarcted area or a distressed area, wherein introducing the treatment agent begins during a low flow time of a blood flow in the coronary artery, wherein the low flow time corresponds to a portion of the cardiac cycle including a period between a QRS complex of the cardiac cycle and a beginning of ventricular relaxation of the cardiac cycle, wherein the treatment agent is introduced at a first volumetric rate during the low flow time of the blood flow in the coronary artery and at a second volumetric rate during a high flow time of the blood flow in the coronary artery, and wherein the first volumetric rate is higher than the second volumetric rate, and occluding the coronary artery, after locally introducing the treatment agent during the low flow time and the high flow time, to stop the blood flow in the coronary artery, wherein the coronary artery is occluded for a dwell time to allow the treatment agent to flow into targeted capillaries that are at least one of in or adjacent to the at least one of the infarcted area or the distressed area.