Patent ID: 9700636
Date: 2017-07-11
CPC Classifications: A61K,A61P,C07K

Claim:
1. A method of treating recessive catecholaminergic polymorphic ventricular tachycardia (CPVT) in a patient having a homozygous mutation in the gene encoding calsequestrin 2 protein (CASQ2), comprising introducing an AAV2/9 vector comprising a nucleic acid comprising a wild-type CASQ2 gene into a cardiomyocyte in the heart of the patient, wherein the wild-type CASQ2 gene encodes a calsequestrin protein having a sequence with 95% or more homology with the sequence of a protein encoded by the nucleotide sequence as set forth in SEQ ID NO: 1 or SEQ ID NO: 2, wherein the introduction of the AAV2/9 vector into the cardiomyocyte has an anti-arrhythmic effect, thereby treating CPVT.