Patent ID: 9545449
Date: 2017-01-17
CPC Classifications: A61K,A61P,C07K

Claim:
1. A pharmaceutical composition comprising a therapeutic compound-having a structure according to formula (I), wherein P represents a multimer of proteins, wherein P comprises 2, 3, or 4 proteins having a solvent accessible thiol, wherein at least one of said proteins has at least 90% sequence identity to SEQ ID NO: 1; each L independently represents an organic linker group; each T independently represents a therapeutic agent, a protein, or a ligand to a biomarker; n is an integer from 0-10; and wherein each L-T moiety present is site-specifically attached to an amino acid residue of P, wherein the compound according to formula (I) represents at least about 75% of biologically active proteins present in the composition, wherein said proteins in P are linked via a chemical modification to said solvent accessible thiol in said proteins; and wherein subunits in P are linked together by:  wherein R  wherein R