Patent ID: 9566249
Date: 2017-02-14
CPC Classifications: A61K,A61P

Claim:
1. A solid oral multiparticulate drug delivery formulation comprising one or more populations of timed, pulsatile release (TPR) beads of one or more slightly acidic drug or a pharmaceutically acceptable salt thereof, wherein the timed, pulsatile release bead comprises: i. a core particle comprising a slightly acidic drug or a pharmaceutically acceptable salt thereof; ii. an optional inner barrier coating comprising a water insoluble polymer that is optionally in combination with a water-soluble/pore-forming polymer; iii. an outer lag-time coating comprising a water-insoluble polymer in combination with an enteric polymer; wherein at least one population of timed, pulsatile release beads provides a lag time of at least 6 hours before onset of drug release; and wherein the total amount of slightly acidic drug contained in the drug delivery formulation is sufficient and the resulting plasma concentration time profile is suitable for once- or twice-daily dosing regimens.