Patent ID: 9532952
Date: 2017-01-03
CPC Classifications: A61K

Claim:
1. A composition comprising a pharmaceutical dosage form having: a solid core including a salicin source and a combination of melatonin and valerian, the melatonin and valerian being located together within a first acidified polymeric matrix; an expedited release portion including 5% to 50% of the salicin source, valerian, and melatonin in the pharmaceutical dosage form, the expedited release portion being effective to release substantially all of the salicin source, valerian, and melatonin therein within about 2 hours from placement in a 0.1 N HCl solution; and a sustained release portion including the remainder of the of the salicin source, valerian and melatonin in the pharmaceutical dosage form, the sustained release portion being effective to release substantially all of the salicin source, valerian, and melatonin therein within about 10 hours from placement in a phosphate buffer with a pH of 6.8.