Patent ID: 9737590
Date: 2017-08-22
CPC Classifications: A61K,Y10T

Claim:
1. A composition comprising sheets of segregated collagenous tissue pieces, wherein said sheets are formed by a process comprising: preparing a plurality of segregated sized pieces of a source material made from unaltered animal or human collagenous tissue selected from the group consisting of dermis, tendon, fascia, and dura mater; dehydrating the plurality of segregated sized pieces of source material; rehydrating the dehydrated pieces in a liquid medium selected from the group comprising Trypsin-Versene liquid medium, a balanced salt solution, Hanks' balanced salt solution, lactated Ringer's solution, and phosphate buffered saline and saline; exposing the rehydrated pieces in the liquid medium to a magnetic field under conditions sufficient to induce the rehydrated pieces to form connecting bridges, without being treated with acid hydrolysis or enzymes, wherein the connecting bridges extend from one source piece to connect another source piece so as to form a self-assembly of collagen fibers as an interconnected collagen structure, whereby the segregated collagenous tissue pieces are coalesced into single collagenous malleable soft structures; and forming the collagenous malleable soft structures into sheets having a thickness of one millimeter or greater.