Patent ID: 9534041
Date: 2017-01-03
CPC Classifications: A61K,A61P,C07K,G01N

Claim:
1. An isolated monoclonal antibody comprising a heavy chain variable domain and a light chain variable domain, wherein the heavy chain variable domain comprises a heavy chain complementarity determining region (HCDR)1, an HCDR2 and an HCDR3, wherein the light chain variable domain comprises an LCDR1, and LCDR2 and an LCDR3, and wherein (a) the HCDR1 comprises the amino acid sequence set forth as SEQ ID NO: 18, the HCDR2 comprises the amino acid sequence set forth as SEQ ID NO: 20, and the HCDR3 comprises the amino acid sequence set forth as SEQ ID NO: 22 and the LCDR1 comprises the amino acid sequence set forth as SEQ ID NO: 26, the LCDR2 comprises the amino acid sequence set forth as SEQ ID NO: 28, and the LCDR3 comprises the amino acid sequence set forth as SEQ ID NO: 30; (b) the HCDR1 comprises the amino acid sequence set forth as SEQ ID NO: 2, the HCDR2 comprises the amino acid sequence set forth as SEQ ID NO: 4, and the HCDR3 comprises the amino acid sequence set forth as SEQ ID NO: 6 and the LCDR1 comprises the amino acid sequence set forth as SEQ ID NO: 10, the LCDR2 comprises the amino acid sequence set forth as SEQ ID NO: 12, and the LCDR3 comprises the amino acid sequence set forth as SEQ ID NO: 14; (c) the HCDR1 comprises the amino acid sequence set forth as SEQ ID NO: 34, the HCDR2 comprises the amino acid sequence set forth as SEQ ID NO: 36, and the HCDR3 comprises the amino acid sequence set forth as SEQ ID NO: 38 and the LCDR1 comprises the amino acid sequence set forth as SEQ ID NO: 42, the LCDR2 comprises the amino acid sequence set forth as SEQ ID NO: 44, and the LCDR3 comprises the amino acid sequence set forth as SEQ ID NO: 46; (d) the HCDR1 comprises the amino acid sequence set forth as SEQ ID NO: 50, the HCDR2 comprises the amino acid sequence set forth as SEQ ID NO: 52, and the HCDR3 comprises the amino acid sequence set forth as SEQ ID NO: 54 and the LCDR1 comprises the amino acid sequence set forth as SEQ ID NO: 58, the LCDR2 comprises the amino acid sequence set forth as SEQ ID NO: 60, and the LCDR3 comprises the amino acid sequence set forth as SEQ ID NO: 62; or (e) the HCDR1 comprises the amino acid sequence set forth in SEQ ID NO: 66, the HCDR2 comprises the amino acid sequence set forth in SEQ ID NO: 68, and the HCDR3 comprises the amino acid sequence set forth as SEQ ID NO: 70 and the LCDR1 comprises the amino acid sequence set forth as SEQ ID NO: 74, the LCDR2 comprises the amino acid sequence set forth as SEQ ID NO: 76, and the LCDR3 comprises the amino acid sequence set forth as SEQ ID NO: 78, and wherein the monoclonal antibody specifically binds to a Norwalk Virus viral protein (VP)1 with a K