Patent ID: 9682979
Date: 2017-06-20
CPC Classifications: A61K,A61P,C07D,Y02A

Claim:
1. A method for treating one or more symptoms of a cancer exhibiting one or more of overexpression, activation, amplification, and mutation of a Trk kinase in a mammal, which comprises administering to said mammal a therapeutically effective amount of a compound of formula I or a pharmaceutically acceptable salt thereof, wherein: R R or NR hetCyc hetCyc hetAr hetAr Cyc Y is (i) phenyl optionally substituted with one or more substituents independently selected from halogen, (1-4C)alkoxy, —CF hetCyc X is —CH R R each R n is 0, 1, 2, 3, 4, 5 or 6; wherein said cancer is selected from the group consisting of neuroblastoma, ovarian cancer, colorectal cancer, pancreatic cancer, breast cancer, prostate cancer, lung cancer, colon cancer, stomach cancer, bladder cancer, uterine cancer, rectal cancer, thyroid cancer, and kidney cancer.