Patent ID: 9694149
Date: 2017-07-04
CPC Classifications: A61M,B65B,B65D,C09K,F04C

Claim:
1. A method of manufacturing medicinal aerosol canisters containing a medicinal formulation comprising particulate drug dispersed in liquefied HFA 134a and/or HFA 227 propellant, wherein the targeted number of canisters to be filled is greater than 500, the method comprising the steps: (a) providing a mixture comprising a particulate drug and liquefied HFA 134a and/or HFA 227 propellant and, optionally, other non-HFA 134a/HFA 227-propellant component or components; either simultaneously or subsequently to said providing (step a), (b) subjecting said mixture to one or more powered ultrasonic probes, said one or more probes being submersed in said mixture, while agitating said mixture; subsequently to said steps of providing and subjecting (steps a and b), (c) filling treated mixture into aerosol containers followed by attaching a valve to each filled container (cold filling) resulting in a filled canister or alternatively filling treated mixture into aerosol containers through a valve pre-attached onto each container (pressure filling) resulting in a filled canister, where said mixture is subjected to at least a total of 200 applied kilowatts times seconds per liter (kW·s/liter).