Patent ID: 9696316
Date: 2017-07-04
CPC Classifications: A61P,C07K,G01N

Claim:
1. A peptide probe for Aβ protein, wherein the peptide probe is a peptide or peptide mimic that comprises an amino acid sequence that (i) is a variant of SEQ ID NO: 1 that differs from SEQ ID NO: 1 by one or more amino acid substitutions selected from G29H, G29R, G29K, and G33E that introduces a salt bridge into the peptide probe sequence wherein G29H, G29R and G29K correspond to residue 14 of SEQ ID NO:1 and G33E corresponds to residue 18 of SEQ ID NO:1; or (ii) comprises the amino acid sequence selected from SEQ ID NOs: 2-4, 14-17, 19-21, 23-24, 28-35, 38-43, 49-50 and 52, having a salt bridge in the peptide probe sequence.