Patent ID: 9744214
Date: 2017-08-29
CPC Classifications: A61K,A61P

Claim:
1. A method for treating or ameliorating a disorder associated with increased or decreased myofibroblast activity, comprising: modulating the myofibroblast level in a subject in need thereof by modulating fibromodulin level in the subject by increasing fibromodulin level or by decreasing fibromodulin level, or modulating myofibroblast differentiation and myofibroblast apoptosis, wherein increasing fibromodulin level comprises applying to the subject an effective amount of fibromodulin for promoting the myofibroblast differentiation and myofibroblast apoptosis thereby increasing the myofibroblast level in the subject where early, but short duration myofibroblast activity is effective for the disorder or inhibiting prolonged myofibroblast activity in the subject where the disorder is associated with prolonged myofibroblast activity, wherein the myofibroblast differentiation is increased by increasing the level of a myofibroblast inducing agent and the myofibroblast apoptosis is induced by a myofibroblast apoptosis inducing agent, and wherein modulating fibromodulin level in the subject comprises effectively modulating the level of fibromodulin activities so as to modulate the myofibroblast apoptosis inducing agent.