Patent ID: 9688748
Date: 2017-06-27
CPC Classifications: A61K,A61P,C07K

Claim:
1. An isolated fully human monoclonal antibody that binds Jagged 1 and Jagged 2, wherein the antibody comprises a combination of amino acid sequences selected from the group consisting of: (a) VH CDR1 sequence comprising the amino acid sequence SYAMS (SEQ ID NO: 200); a VH CD2 sequence comprising the amino acid sequence SIDPEGRQTYYADSVKG (SEQ ID NO: 208); a VH CDR3 sequence comprising the amino acid sequence DIGGRSAFDY (SEQ ID NO: 209); a VL CDR1 sequence comprising the amino acid sequence RASQSISSY (SEQ ID NO: 210); a VL CDR2 sequence comprising the amino acid sequence AASSLQS (SEQ ID NO: 211); and a VL CDR3 sequence comprising the amino acid sequence QQTVVAPPL (SEQ ID NO: 212), (b) a combination of a VII CDR1 sequence, a VII CDR2 sequence, a VII CDR3 sequence, a VL CDR1 sequence, a VL CDR2 sequence, and a VL CDR3 sequence selected from the combinations shown in Table 2, and (c) a combination of a variable heavy chain region and a variable light chain region from the combinations listed in Table 4.