Patent ID: 9662386
Date: 2017-05-30
CPC Classifications: A61K,A61P,C07K,C12N,Y02A

Claim:
1. A method of enhancing systemic and mucosal immune responses against a vaccine antigen in a subject, comprising administering to the subject an adjuvant comprising a protein complex composed of hemagglutinin (HA) subcomponents HA1, HA 2, and HA3of botulinum toxin in combination with the vaccine antigen, wherein the protein complex is composed of (i) a protein consisting of the amino acid sequence as shown in SEQ ID NO : 1, (ii) a protein consisting of the amino acid sequence as shown in SEQ ID NO: 2 , and (iii) a protein consisting of the amino acid sequence as shown in SEQ ID NO : 3.