Patent ID: 9540412
Date: 2017-01-10
CPC Classifications: A61K,C07H,C12N

Claim:
1. A process of preparing a nucleoside analog-containing-oligonucleotide for selective introduction into a subject's cells, the process comprising selecting a targeted aptamer via iterative rounds of selection against the subject's cells or against cells corresponding to the subject's cells to which the oligonucleotide is to be selectively introduced, then modifying the selected targeted aptamer with a 24 nucleotide extension, and then hybridizing a nucleoside analog-containing-oligonucleotide sufficiently complementary to hybridize to the modified selected targeted aptamer so as to prepare the nucleoside analog-containing-oligonucleotide, wherein the targeted aptamer comprises the oligonucleotide sequence set forth in SEQ ID NO: 1, 2, 3, 4, 5, 11 or 12, or wherein the modified selected targeted aptamer comprises the oligonucleotide sequence set forth in SEQ ID NO: 6.