Patent ID: 9718921
Date: 2017-08-01
CPC Classifications: A61K,C08G

Claim:
1. A process for preparing an amphiphilic block copolypeptide with oxidized thioether groups comprising: synthesizing a block copolypeptide wherein at least one of the blocks contains at least 3 consecutive hydrophobic amino acids selected from leucine, phenylalanine, alanine, isoleucine, valine, tyrosine, and tryptophan, and wherein at least one of the blocks contains at least 3 consecutive thioether containing amino acids selected from methionine, S-methyl-cysteine, S-ethyl-cysteine, S-allyl-cysteine, S-benzyl-cysteine, S-farnesyl-cysteine, S-propargyl-cysteine, S-methyl-homocysteine, S-ethyl-homocysteine, S-allyl-homocysteine, S-benzyl-homocysteine, S-farnesyl-homocysteine, and S-propargyl-homocysteine; adding an oxidizing reagent to the block copolypeptide; and reacting the block copolypeptide so that the majority of the thioether groups in the polypeptide are oxidized, thereby forming the amphiphilic block copolypeptide with oxidized thioether groups.