Patent ID: 9662299
Date: 2017-05-30
CPC Classifications: A61K,B82Y,G01N

Claim:
1. A yeast cell wall particle-nanoparticle (YCWP-NP) delivery system, comprising yeast cell wall particles (YCWPs) comprising nanoparticles (NPs) having at least one dimension of about 10-1000 nm on the exterior surface of the YCWPs, wherein the YCWP delivery system is prepared by a process comprising the steps of: (a) loading the NPs onto the YCWPs, wherein the loading comprises incubating a suspension comprising YCWPs and NPs for a time sufficient for the NPs to bind to the YCWPs, wherein the YCWPs have a trapping polymer covalently linked to the surface of the YCWPs, and wherein the YCWPs are surface-derivatized to have an electrostatic surface such that NP binding is facilitated, (b) washing and/or dispersing the material resulting from (a) and (c) optionally repeating steps (a)-(b) at least once, such that the YCWP-NP delivery system is prepared.