Patent ID: 9539338
Date: 2017-01-10
CPC Classifications: A61K,C08F,C08H,C12Y

Claim:
1. A method comprising: in an aqueous solution, immobilizing an active ester-functionalized amide-containing controlled radical polymerization CRP initiator comprised of the structure wherein X is a halogen or a chain transfer agent; R R n is an integer from 1 to 6, on each of a plurality of amino binding sites on a protein surface to form a protein-initiator conjugate; isolating the protein-initiator conjugate; mixing a first group of monomers having one or more desired properties with the protein-initiator conjugate; polymerizing the monomers from the protein-initiator conjugate to grow a polymer under controlled radical polymerization conditions to form a protein-polymer conjugate; and, isolating the protein-polymer conjugate.