Patent ID: 9534049
Date: 2017-01-03
CPC Classifications: A61K,A61P,C07K

Claim:
1. A humanized antibody that immunospecifically binds to a Toll-like receptor 4 (TLR4)/MD-2 complex, wherein the antibody comprises a heavy chain with three complementarity determining regions (CDRs) comprising a variable heavy chain complementarity determining region 1 (VH CDR1) comprising the amino acid sequence DSYIH (SEQ ID NO: 91); a variable heavy chain complementarity determining region 2 (VH CDR2) comprising the amino acid sequence WTDPENVNSIYDPRFQG (SEQ ID NO: 92), and a variable heavy chain complementarity determining region 3 (VH CDR3) comprising the amino acid sequence GYNGVYYAMDY (SEQ ID NO: 93); and a light chain with three CDRs comprising a variable light chain complementarity determining region 1 (VL CDR1) comprising the amino acid sequence SASSSVIYMH (SEQ ID NO: 94); a variable light chain complementarity determining region 2 (VL CDR2) comprising the amino acid sequence RTYNLAS (SEQ ID NO: 95); and a variable light chain complementarity determining region 3 (VL CDR3) comprising the amino acid sequence HQWSSFPYT (SEQ ID NO: 96).