Patent ID: 9579289
Date: 2017-02-28
CPC Classifications: A61K,A61P

Claim:
1. A controlled release oral dosage form comprising: a) a core comprising (R)-baclofen (ARBAC), at least one disintegrant, at least one osmotic agent, at least one binder, at least one water swellable cellulose derivative (CD) polymer and at least one water swellable polyalkylene oxide (PAO) polymer, wherein the amount of PAO polymer exceeds the amount of CD polymer; and b) a semipermeable membrane surrounding the core, said membrane comprising at least two different grades of cellulose acetate polymer and at least one preformed passageway; wherein: about 60 to about 100% wt of the drug is released over a period of about 6 to about 16 hours under conditions defined in USP <711> using a Type II apparatus with 0.1 N HCl stirred at 50 rpm and maintained at a temperature of 37±0.5° C.; and following oral administration to a subject, the dosage form provides a majority of drug release from the core downstream of the stomach and upstream of the colon.