Patent ID: 9603933
Date: 2017-03-28
CPC Classifications: A61K

Claim:
1. A composition for enteric hard capsules, the composition comprising: about 50 parts to about 90 parts by weight of hydroxypropyl methylcellulose phthalate (HPMCP), wherein the HPMCP includes about 20 wt % to about 24 wt % of a methoxy group, about 6 wt % to about 10 wt % of a hydroxypropoxy group, and about 21 wt % to about 26 wt % of a phthalyl group, and has a kinetic viscosity of about 48 cSt to about 66 cSt; about 10 parts to about 50 parts by weight of hydroxypropyl methylcellulose (HPMC); about 5.5 to about 8.5 parts by weight of an alkaline agent; and about 5 parts to about 15 parts by weight of a polyol having at least three hydroxyl groups, wherein the amounts of the HPMCP, the HPMC, the alkaline agent and the polyol in parts by weight are based on 100 parts by weight of the total weight of the HPMCP and the HPMC, wherein the polyol serves as a plasticizer delaying the separation of salts from a capsule prepared from the composition, and wherein the polyol having the at least three hydroxyl groups comprises glycerin.