Patent ID: 9592221
Date: 2017-03-14
CPC Classifications: A61K,A61P,C07D,Y02A

Claim:
1. A method of inhibiting a bacterial RNA polymerase, comprising contacting a bacterial RNA polymerase with a compound of formula Ia, Ib or Ic: or a salt thereof, wherein: W is sulfur, oxygen, or nitrogen; X, Y, and Z are individually carbon, sulfur, oxygen, or nitrogen, wherein at least two of X, Y, and Z are carbon; one of R one of R R R V′, W′, X′, Y′, and Z′ are individually carbon or nitrogen; wherein at least three of V′, W′, X′, Y′, and Z′ are carbon; one of R one of R R W″ is sulfur, oxygen, or nitrogen; U″, V″, X″, Y″, and Z″ are individually carbon, sulfur, oxygen, or nitrogen, wherein at least three of U″, V″, X″, Y″, and Z″ are carbon; one of R one of R R R R G is one of —CH═CH—NHC(O)—R R each R R each R each R