Patent ID: 9569586
Date: 2017-02-14
CPC Classifications: G01N,G16B,G16H

Claim:
1. A computer-implemented method for identifying wild type or mutated target genes or regulatory elements for cancer therapy, comprising: identifying constraints mediated by a cancer genome architecture on somatic cancer evolution in a human cancer patient; identifying target genes which are involved in mediating the constraints, and which are not from classes of genes including, oncogenes, tumor suppressor genes, or caretaker genes, the identifying the target genes comprising: constructing a phylogenetic tree of somatic cancer evolution of a malignant human tumor within the human cancer patient based on multiple clinical samples of tissue from the human cancer patient, which are representative of clinical cancer progression within the human cancer patient, wherein the constructing the phylogenetic tree of somatic cancer evolution comprises the steps of: wherein the cancer genome architecture comprises: