Patent ID: 9677038
Date: 2017-06-13
CPC Classifications: B01D,C12M,C12N,C12P

Claim:
1. A bio-reactor for culturing micro organisms in suspension, wherein said bio-reactor has a) a volume comprising a member selected from the group consisting of an envelope, a matrix, a scaffolding, a porous body and/or a packed bed of growth bodies for hosting micro organisms in suspension, and b) one or more bio-reactor inlet port(s) and one or more bio-reactor outlet port(s), wherein said envelope, matrix, scaffolding, porous body and/or packed bed of growth bodies is suitable for supporting the cultivation of micro organisms in suspension and expression of biologic compounds, wherein said envelope, matrix, scaffolding, porous body and/or packed bed of growth bodies separates said one or more bio-reactor inlet port(s) from said one or more bio-reactor outlet port(s), wherein the envelope, matrix, scaffolding, porous body and/or packed bed of growth bodies is in direct contact with one feeding spacer section and one drainage spacer section, respectively, on opposite sides of the matrix, scaffolding, porous body and/or packed bed of growth bodies, wherein the feeding spacer section and drainage spacer section is a member selected from the group consisting of a layer of flow-nets, screens, corrugated sheets, nettings or rib stiffeners, set of ribs or discs with a radial set of ribs or combinations thereof and wherein a gradient free laminar flow is created in the volume comprising a member selected from the group consisting of an envelope, a matrix, a scaffolding, a porous body and/or a packed bed of growth bodies when fluid is introduced into the bio-reactor inlet port.