Patent ID: 9573957
Date: 2017-02-21
CPC Classifications: A61K,A61P,C07D

Claim:
1. A compound selected from the group consisting of: 1-{6-[5-(2H-Pyrazol-3-yl)-pyridin-2-yloxy]-naphthalen-2-ylmethyl}-azetidin-3-ol; 1-{6-[5-(2H-Pyrazol-3-yl)-pyridin-2-yloxy]-naphthalen-2-ylmethyl}-azetidine-3-carboxylic acid amide; N-(1-{6-[5-(2H-Pyrazol-3-yl)-pyridin-2-yloxy]-naphthalen-2-ylmethyl}-azetidin-3-yl)-acetamide; (1-{6-[5-(2H-Pyrazol-3-yl)-pyridin-2-yloxy]-naphthalen-2-ylmethyl}-azetidin-3-yl)-methanol; (S)-1-{6-[5-(2H-Pyrazol-3-yl)-pyridin-2-yloxy]-naphthalen-2-ylmethyl}-pyrrolidin-3-ol; (R)-1-{6-[5-(2H-Pyrazol-3-yl)-pyridin-2-yloxy]-naphthalen-2-ylmethyl}-pyrrolidin-3-ol; 2-Hydroxy-1-(4-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-naphthalen-2-ylmethyl}-piperazin-1-yl)-ethanone; (S)-3-Hydroxy-1-(1-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-quinolin-2-ylmethyl}-piperidin-4-yl)-pyrrolidin-2-one; 2-Hydroxy-N-(1-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-naphthalen-2-ylmethyl}-piperidin-4-yl)-acetamide; 2-{6-[5-(2H-Pyrazol-3-yl)-pyridin-2-yloxy]-naphthalen-2-ylmethyl}-2-aza-spiro[3.3]heptan-6-ol; 3-Methyl-1-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-naphthalen-2-ylmethyl}-azetidin-3-ol; N-((R)-1-{6-[5-(2H-Pyrazol-3-yl)-pyridin-2-yloxy]-naphthalen-2-ylmethyl}-pyrrolidin-3-yl)-acetamide; N-((S)-1-{6-[5-(2H-Pyrazol-3-yl)-pyridin-2-yloxy]-naphthalen-2-ylmethyl}-pyrrolidin-3-yl)-acetamide; (S)-1-{6-[5-(2H-Pyrazol-3-yl)-pyridin-2-yloxy]-naphthalen-2-ylmethyl}-piperidin-3-ol; (R)-1-{6-[5-(2H-Pyrazol-3-yl)-pyridin-2-yloxy]-naphthalen-2-ylmethyl}-piperidin-3-ol; 2-(Methyl-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-naphthalen-2-ylmethyl}-amino)-ethanol; (1-{6-[5-(2H-Pyrazol-3-yl)-pyridin-2-yloxy]-naphthalen-2-ylmethyl}-piperidin-4-yl)-methanol; ((S)-1-{6-[5-(2H-Pyrazol-3-yl)-pyridin-2-yloxy]-naphthalen-2-ylmethyl}-pyrrolidin-3-yl)-methanol; 2-Hydroxy-1-[(R)-3-(methyl-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-naphthalen-2-ylmethyl}-amino)-pyrrolidin-1-yl]-ethanone; 2-Hydroxy-N-methyl-N-((S)-1-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-naphthalen-2-ylmethyl}-pyrrolidin-3-yl)-acetamide; 2-Hydroxy-N-methyl-N-((R)-1-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-naphthalen-2-ylmethyl}-pyrrolidin-3-yl)-acetamide; ((R)-1-{6-[5-(2H-Pyrazol-3-yl)-pyridin-2-yloxy]-naphthalen-2-ylmethyl}-pyrrolidin-3-yl)-methanol; 2-Hydroxy-1-[(S)-3-(methyl-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-naphthalen-2-ylmethyl}-amino)-pyrrolidin-1-yl]-ethanone; 2-Methoxy-1-(4-{6-[5-(2H-pyrazol-3-yl)-pyrimidin-2-yloxy]-naphthalen-2-ylmethyl}-piperazin-1-yl)-ethanone; 1-(4-{6-[5-(2H-Pyrazol-3-yl)-pyrimidin-2-yloxy]-naphthalen-2-ylmethyl}-piperazin-1-yl)-ethanone; 1-{6-[5-(2H-Pyrazol-3-yl)-pyrimidin-2-yloxy]-naphthalen-2-ylmethyl}-piperidin-4-ol; 1-{6-[5-(2H-Pyrazol-3-yl)-pyrimidin-2-yloxy]-naphthalen-2-ylmethyl}-piperidine-4-carboxylic acid amide; N-(1-{6-[5-(2H-Pyrazol-3-yl)-pyrimidin-2-yloxy]-naphthalen-2-ylmethyl}-piperidin-4-yl)-acetamide; (S)-3-Hydroxy-1-(1-{6-[5-(2H-pyrazol-3-yl)-pyrimidin-2-yloxy]-naphthalen-2-ylmethyl}-piperidin-4-yl)-pyrrolidin-2-one; (S)-2-Hydroxy-1-(4-{6-[5-(2H-pyrazol-3-yl)-pyrimidin-2-yloxy]-naphthalen-2-ylmethyl}-piperazin-1-yl)-propan-1-one; 2-Hydroxy-N-methyl-N-(1-{6-[5-(2H-pyrazol-3-yl)-pyrimidin-2-yloxy]-naphthalen-2-ylmethyl}-piperidin-4-yl)-acetamide; 1-{3-[(Methyl-{6-[5-(2H-pyrazol-3-yl)-pyrimidin-2-yloxy]-naphthalen-2-ylmethyl}-amino)-methyl]-azetidin-1-yl}-ethanone; 3-(1-{6-[5-(2H-Pyrazol-3-yl)-pyrimidin-2-yloxy]-naphthalen-2-ylmethyl}-piperidin-4-yl)-oxazolidin-2-one; 4-{6-[5-(2H-Pyrazol-3-yl)-pyrimidin-2-yloxy]-naphthalen-2-ylmethyl}-piperazine-1-carboxylic acid dimethylamide; 2,2-Dimethyl-1-(4-{6-[5-(2H-pyrazol-3-yl)-pyrimidin-2-yloxy]-naphthalen-2-ylmethyl}-piperazin-1-yl)-propan-1-one; 1-(1-{6-[5-(2H-Pyrazol-3-yl)-pyrimidin-2-yloxy]-naphthalen-2-ylmethyl}-piperidin-4-yl)-pyrrolidin-2-one; 1-(4-{6-[5-(2H-Pyrazol-3-yl)-pyrimidin-2-yloxy]-naphthalen-2-ylmethyl}-piperazin-1-yl)-propan-1-one; 1-{6-[5-(2H-Pyrazol-3-yl)-pyrimidin-2-yloxy]-naphthalen-2-ylmethyl}-piperidine-4-carboxylic acid dimethylamide; 2-Hydroxy-2-methyl-1-(4-{6-[5-(2H-pyrazol-3-yl)-pyrimidin-2-yloxy]-naphthalen-2-ylmethyl}-piperazin-1-yl)-propan-1-one; Cyclopropyl-(4-{6-[5-(2H-pyrazol-3-yl)-pyrimidin-2-yloxy]-naphthalen-2-ylmethyl}-piperazin-1-yl)-methanone; 2-Methyl-1-(4-{6-[5-(2H-pyrazol-3-yl)-pyrimidin-2-yloxy]-naphthalen-2-ylmethyl}-piperazin-1-yl)-propan-1-one; 1-{6-[5-(2H-Pyrazol-3-yl)-pyridin-2-yloxy]-quinolin-2-ylmethyl}-azetidin-3-ol; 3-({6-[5-(2H-Pyrazol-3-yl)-pyridin-2-yloxy]-quinolin-2-ylmethyl}-amino)-propionitrile; (R)-3-({6-[5-(2H-Pyrazol-3-yl)-pyridin-2-yloxy]-quinolin-2-ylmethyl}-amino)-pentanenitrile; (R)-1-{6-[5-(2H-Pyrazol-3-yl)-pyrimidin-2-yloxy]-naphthalen-2-ylmethyl}-pyrrolidin-3-ol; (S)-1-{6-[5-(2H-Pyrazol-3-yl)-pyrimidin-2-yloxy]-naphthalen-2-ylmethyl}-pyrrolidin-3-ol; 3-Methyl-1-{6-[5-(2H-pyrazol-3-yl)-pyrimidin-2-yloxy]-naphthalen-2-ylmethyl}-azetidin-3-ol; 2-Hydroxy-1-(4-{6-[5-(2H-pyrazol-3-yl)-pyrimidin-2-yloxy]-naphthalen-2-ylmethyl}-piperazin-1-yl)-ethanone; 1-{6-[5-(2H-Pyrazol-3-yl)-pyrimidin-2-yloxy]-naphthalen-2-ylmethyl}-azetidin-3-ol; 3-Oxo-3-(8-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-quinolin-2-ylmethyl}-3,8-diaza-bicyclo[3.2.1]oct-3-yl)-propionitrile; 2,2-Dimethyl-3-oxo-3-(8-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-quinolin-2-ylmethyl}-3,8-diaza-bicyclo[3.2.1]oct-3-yl)-propionitrile; (R)-2-Methoxy-1-(8-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-quinolin-2-ylmethyl}-3,8-diaza-bicyclo[3.2.1]oct-3-yl)-propan-1-one; (S)-2-Methoxy-1-(8-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-quinolin-2-ylmethyl}-3,8-diaza-bicyclo[3.2.1]oct-3-yl)-propan-1-one; (8-{6-[5-(2H-Pyrazol-3-yl)-pyridin-2-yloxy]-quinolin-2-ylmethyl}-3,8-diaza-bicyclo[3.2.1]oct-3-yl)-(R)-tetrahydro-furan-2-yl-methanone; (8-{6-[5-(2H-Pyrazol-3-yl)-pyridin-2-yloxy]-quinolin-2-ylmethyl}-3,8-diaza-bicyclo[3.2.1]oct-3-yl)-(S)-tetrahydro-furan-2-yl-methanone; (1-Hydroxy-cyclopropyl)-(8-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-quinolin-2-ylmethyl}-3,8-diaza-bicyclo[3.2.1]oct-3-yl)-methanone; (S)-2-Hydroxy-1-(8-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-quinolin-2-ylmethyl}-3,8-diaza-bicyclo[3.2.1]oct-3-yl)-propan-1-one; 2-Hydroxy-2-methyl-1-(8-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-quinolin-2-ylmethyl}-3,8-diaza-bicyclo[3.2.1]oct-3-yl)-propan-1-one; (R)-2-Hydroxy-1-(8-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-quinolin-2-ylmethyl}-3,8-diaza-bicyclo[3.2.1]oct-3-yl)-propan-1-one; 2-Methoxy-1-(8-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-quinolin-2-ylmethyl}-3,8-diaza-bicyclo[3.2.1]oct-3-yl)-ethanone; (S)-3-Hydroxy-1-(1-{(S)-6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-2,3-dihydro-benzofuran-2-ylmethyl}-piperidin-4-yl)-pyrrolidin-2-one; (S)-3-Hydroxy-1-(1-{(R)-6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-2,3-dihydro-benzofuran-2-ylmethyl}-piperidin-4-yl)-pyrrolidin-2-one; 1-(1-{(R)-6-[5-(2H-Pyrazol-3-yl)-pyridin-2-yloxy]-2,3-dihydro-benzofuran-2-ylmethyl}-piperidin-4-yl)-pyrrolidin-2-one; 1-(1-{(S)-6-[5-(2H-Pyrazol-3-yl)-pyridin-2-yloxy]-2,3-dihydro-benzofuran-2-ylmethyl}-piperidin-4-yl)-pyrrolidin-2-one; 2-Hydroxy-1-(4-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-2,3-dihydro-benzofuran-2-ylmethyl}-piperazin-1-yl)-ethanone; 2-(4-Methanesulfonyl-piperazin-1-ylmethyl)-6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-quinoline; 2-(4-Ethanesulfonyl-piperazin-1-ylmethyl)-6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-quinoline; 1-[1-(2-{6-[5-(2H-Pyrazol-3-yl)-pyridin-2-yloxy]-2,3-dihydro-benzofuran-3-yl}-ethyl)-piperidin-4-yl]-pyrrolidin-2-one; 3-[1-(2-{6-[5-(2H-Pyrazol-3-yl)-pyridin-2-yloxy]-2,3-dihydro-benzofuran-3-yl}-ethyl)-piperidin-4-yl]-oxazolidin-2-one; (S)-3-Hydroxy-1-[1-(2-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-2,3-dihydro-benzofuran-3-yl}-ethyl)-piperidin-4-yl]-pyrrolidin-2-one; 1-Methanesulfonyl-4-(2-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-2,3-dihydro-benzofuran-3-yl}-ethyl)-piperazine; 1-[1-(2-{6-[5-(2H-Pyrazol-3-yl)-pyridin-2-yloxy]-benzofuran-3-yl}-ethyl)-piperidin-4-yl]-pyrrolidin-2-one; (S)-3-Hydroxy-1-[1-(2-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-benzofuran-3-yl}-ethyl)-piperidin-4-yl]-pyrrolidin-2-one; 1-Methanesulfonyl-4-(2-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-benzofuran-3-yl}-ethyl)-piperazine; (S)-2-Methoxy-1-[4-(2-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-benzofuran-3-yl}-ethyl)-piperazin-1-yl]-propan-1-one; (R)-2-Methoxy-1-[4-(2-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-2,3-dihydro-benzofuran-3-yl}-ethyl)-piperazin-1-yl]-propan-1-one; 2-Methoxy-1-[4-(2-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-benzofuran-3-yl}-ethyl)-piperazin-1-yl]-ethanone; (R)-2-Methoxy-1-[4-(2-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-benzofuran-3-yl}-ethyl)-piperazin-1-yl]-propan-1-one; (S)-2-Methoxy-1-(4-{6-[4-(2H-pyrazol-3-yl)-phenoxy]-imidazo[1,2-a]pyridin-2-ylmethyl}-piperazin-1-yl)-propan-1-one; (R)-2-Methoxy-1-(4-{6-[4-(2H-pyrazol-3-yl)-phenoxy]-imidazo[1,2-a]pyridin-2-ylmethyl}-piperazin-1-yl)-propan-1-one; 2-Hydroxy-2-methyl-1-[4-(2-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-2,3-dihydro-benzofuran-3-yl}-ethyl)-piperazin-1-yl]-propan-1-one; 2-Hydroxy-1-[4-(2-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-benzofuran-3-yl}-ethyl)-piperazin-1-yl]-ethanone; (S)-2-Hydroxy-1-[4-(2-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-benzofuran-3-yl}-ethyl)-piperazin-1-yl]-propan-1-one; (S)-2-Hydroxy-1-[4-(2-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-2,3-dihydro-benzofuran-3-yl}-ethyl)-piperazin-1-yl]-propan-1-one; 2-Hydroxy-2-methyl-1-[4-(2-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-benzofuran-3-yl}-ethyl)-piperazin-1-yl]-propan-1-one; 2-Hydroxy-1-(4-{6-[4-(2H-pyrazol-3-yl)-phenoxy]-imidazo[1,2-a]pyridin-2-ylmethyl}-piperazin-1-yl)-ethanone; (S)-2-Hydroxy-1-(4-{6-[4-(2H-pyrazol-3-yl)-phenoxy]-imidazo[1,2-a]pyridin-2-ylmethyl}-piperazin-1-yl)-propan-1-one; (S)-2-Methoxy-1-[4-(2-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-2,3-dihydro-benzofuran-3-yl}-ethyl)-piperazin-1-yl]-propan-1-one; 2-Methoxy-1-(4-{6-[4-(2H-pyrazol-3-yl)-phenoxy]-imidazo[1,2-a]pyridin-2-ylmethyl}-piperazin-1-yl)-ethanone; (1-Hydroxy-cyclopropyl)-[4-(2-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-2,3-dihydro-benzofuran-3-yl}-ethyl)-piperazin-1-yl]-methanone; (R)-2-Hydroxy-1-[4-(2-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-2,3-dihydro-benzofuran-3-yl}-ethyl)-piperazin-1-yl]-propan-1-one; (R)-2-Hydroxy-1-[4-(2-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-benzofuran-3-yl}-ethyl)-piperazin-1-yl]-propan-1-one; (1-Hydroxy-cyclopropyl)-[4-(2-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-benzofuran-3-yl}-ethyl)-piperazin-1-yl]-methanone; (R)-2-Hydroxy-1-(4-{6-[4-(2H-pyrazol-3-yl)-phenoxy]-imidazo[1,2-a]pyridin-2-ylmethyl}-piperazin-1-yl)-propan-1-one; 1-(4-{6-[4-(2H-Pyrazol-3-yl)-phenoxy]-imidazo[1,2-a]pyridin-2-ylmethyl}-piperazin-1-yl)-ethanone; (1-Hydroxy-cyclopropyl)-(4-{6-[4-(2H-pyrazol-3-yl)-phenoxy]-imidazo[1,2-a]pyridin-2-ylmethyl}-piperazin-1-yl)-methanone; 1-(4-{6-[5-(2H-Pyrazol-3-yl)-pyridin-2-yloxy]-benzofuran-3-ylmethyl}-[1,4]diazepan-1-yl)-ethanone; 2-Hydroxy-N-methyl-N-((R)-1-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-quinolin-2-ylmethyl}-pyrrolidin-3-yl)-acetamide; 2-Hydroxy-N-methyl-N-((S)-1-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-quinolin-2-ylmethyl}-pyrrolidin-3-yl)-acetamide; 2-Hydroxy-1-[(R)-3-(methyl-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-quinolin-2-ylmethyl}-amino)-pyrrolidin-1-yl]-ethanone; 2-Hydroxy-1-[(S)-3-(methyl-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-quinolin-2-ylmethyl}-amino)-pyrrolidin-1-yl]-ethanone; 2-Hydroxy-1-(7-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-quinolin-2-ylmethyl}-2,7-diaza-spiro[4.4]non-2-yl)-ethanone; 1-{6-[5-(2H-Pyrazol-3-yl)-pyridin-2-yloxy]-benzofuran-3-ylmethyl}-piperidine-4-carboxylic acid methylamide; N-(1-{6-[5-(2H-Pyrazol-3-yl)-pyridin-2-yloxy]-benzofuran-3-ylmethyl}-piperidin-4-yl)-acetamide; N-(1-{6-[5-(2H-Pyrazol-3-yl)-pyridin-2-yloxy]-benzofuran-3-ylmethyl}-piperidin-4-yl)-methanesulfonamide; N-(1-{6-[5-(2H-Pyrazol-3-yl)-pyridin-2-yloxy]-benzofuran-3-ylmethyl}-piperidin-4-ylmethyl)-acetamide; 1-{4-[({6-[5-(2H-Pyrazol-3-yl)-pyridin-2-yloxy]-benzofuran-3-ylmethyl}-amino)-methyl]-piperidin-1-yl}-ethanone; 1-[4-({6-[5-(2H-Pyrazol-3-yl)-pyridin-2-yloxy]-benzofuran-3-ylmethyl}-amino)-piperidin-1-yl]-ethanone; (S)-3-Hydroxy-1-(1-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-benzofuran-3-ylmethyl}-piperidin-4-yl)-pyrrolidin-2-one; 2-Methyl-8-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-benzofuran-3-ylmethyl}-2,8-diaza-spiro[4.5]decan-1-one; 2-(4-{6-[5-(2H-Pyrazol-3-yl)-pyridin-2-yloxy]-benzofuran-3-ylmethyl}-piperazin-1-yl)-1-pyrrolidin-1-yl-ethanone; 1-(4-{6-[5-(2H-Pyrazol-3-yl)-pyridin-2-yloxy]-benzofuran-3-carbonyl}-piperazin-1-yl)-ethanone; 2-Hydroxy-N-methyl-N-((R)-1-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-benzofuran-3-ylmethyl}-pyrrolidin-3-yl)-acetamide; 2-Hydroxy-N-methyl-N-((S)-1-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-benzofuran-3-ylmethyl}-pyrrolidin-3-yl)-acetamide; 2-Hydroxy-1-(7-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-benzofuran-3-ylmethyl}-2,7-diaza-spiro[4.4]non-2-yl)-ethanone; 1-(4-{6-[5-(2H-Pyrazol-3-yl)-pyridin-2-yloxy]-quinolin-2-ylmethyl}-piperazine-1-carbonyl)-cyclopropanecarbonitrile; (S)-3-Hydroxy-1-(4-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-quinolin-2-ylmethyl}-piperazin-1-yl)-butan-1-one; (S)-2-Methoxy-1-(4-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-quinolin-2-ylmethyl}-piperazin-1-yl)-propan-1-one; (1-Hydroxy-cyclopentyl)-(4-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-quinolin-2-ylmethyl}-piperazin-1-yl)-methanone; (R)-2-Hydroxy-3-methyl-1-(4-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-quinolin-2-ylmethyl}-piperazin-1-yl)-butan-1-one; (R)-3-Hydroxy-1-(4-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-quinolin-2-ylmethyl}-piperazin-1-yl)-butan-1-one; 3-Hydroxy-3-methyl-1-(4-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-quinolin-2-ylmethyl}-piperazin-1-yl)-butan-1-one; (R)-2-Hydroxy-1-(4-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-quinolin-2-ylmethyl}-piperazin-1-yl)-propan-1-one; 2-Ethoxy-1-(4-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-quinolin-2-ylmethyl}-piperazin-1-yl)-ethanone; 2-Hydroxy-2-methyl-1-(4-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-quinolin-2-ylmethyl}-piperazin-1-yl)-propan-1-one; (1-Hydroxy-cyclopropyl)-(4-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-quinolin-2-ylmethyl}-piperazin-1-yl)-methanone; (S)-2-Hydroxy-1-(4-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-quinolin-2-ylmethyl}-piperazin-1-yl)-butan-1-one; 2-Methoxy-2-methyl-1-(4-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-quinolin-2-ylmethyl}-piperazin-1-yl)-propan-1-one; (S)-2-Hydroxy-1-(4-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-quinolin-2-ylmethyl}-piperazin-1-yl)-propan-1-one; 2-Isopropoxy-1-(4-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-quinolin-2-ylmethyl}-piperazin-1-yl)-ethanone; (4-{6-[5-(2H-Pyrazol-3-yl)-pyridin-2-yloxy]-quinolin-2-ylmethyl}-piperazin-1-yl)-(tetrahydro-pyran-4-yl)-methanone; (4-{6-[5-(2H-Pyrazol-3-yl)-pyridin-2-yloxy]-quinolin-2-ylmethyl}-piperazin-1-yl)-(S)-tetrahydro-furan-2-yl-methanone; (4-{6-[5-(2H-Pyrazol-3-yl)-pyridin-2-yloxy]-quinolin-2-ylmethyl}-piperazin-1-yl)-(R)-tetrahydro-furan-2-yl-methanone; (R)-2-Hydroxy-1-(4-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-quinolin-2-ylmethyl}-piperazin-1-yl)-butan-1-one; 3-Hydroxy-2,2-dimethyl-1-(4-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-quinolin-2-ylmethyl}-piperazin-1-yl)-propan-1-one; (3-Oxa-bicyclo[3.1.0]hex-6-yl)-(4-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-quinolin-2-ylmethyl}-piperazin-1-yl)-methanone; (S)-2-Hydroxy-3-methyl-1-(4-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-quinolin-2-ylmethyl}-piperazin-1-yl)-butan-1-one; (1-Hydroxymethyl-cyclopropyl)-(4-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-quinolin-2-ylmethyl}-piperazin-1-yl)-methanone; (3-Hydroxy-cyclobutyl)-(4-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-quinolin-2-ylmethyl}-piperazin-1-yl)-methanone; (R)-2-Methoxy-1-(4-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-quinolin-2-ylmethyl}-piperazin-1-yl)-propan-1-one; (4-{6-[5-(2H-Pyrazol-3-yl)-pyridin-2-yloxy]-quinolin-2-ylmethyl}-piperazin-1-yl)-(R)-tetrahydro-furan-3-yl-methanone; 4-Methoxy-1-(4-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-quinolin-2-ylmethyl}-piperazin-1-yl)-butan-1-one; (1-Hydroxy-cyclobutyl)-(4-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-quinolin-2-ylmethyl}-piperazin-1-yl)-methanone; 2-Propoxy-1-(4-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-quinolin-2-ylmethyl}-piperazin-1-yl)-ethanone; 2,2-Dimethyl-3-oxo-3-(4-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-quinolin-2-ylmethyl}-piperazin-1-yl)-propionitrile; 1-(4-{6-[5-(2H-Pyrazol-3-yl)-pyridin-2-yloxy]-quinolin-2-ylmethyl}-piperazine-1-carbonyl)-cyclobutanecarbonitrile; 1-(4-{6-[5-(2H-Pyrazol-3-yl)-pyridin-2-yloxy]-quinolin-2-ylmethyl}-piperazine-1-carbonyl)-cyclopentanecarbonitrile; 4-(4-{6-[5-(2H-Pyrazol-3-yl)-pyridin-2-yloxy]-quinolin-2-ylmethyl}-piperazine-1-carbonyl)-tetrahydro-pyran-4-carbonitrile; 2-Methyl-3-oxo-3-(4-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-quinolin-2-ylmethyl}-piperazin-1-yl)-propionitrile; (3-Hydroxy-3-methyl-cyclobutyl)-(4-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-quinolin-2-ylmethyl}-piperazin-1-yl)-methanone; and ((1R,2S)-2-Hydroxy-cyclopentyl)-(4-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-quinolin-2-ylmethyl}-piperazin-1-yl)-methanone; 2-Methoxy-1-(4-{6-[5-(2H-pyrazol-3-yl)-pyrimidin-2-yloxy]-naphthalen-2-ylmethyl}-piperazin-1-yl)-ethanone; 1-(4-{6-[5-(2H-Pyrazol-3-yl)-pyrimidin-2-yloxy]-naphthalen-2-ylmethyl}-piperazin-1-yl)-ethanone; 1-{6-[5-(2H-Pyrazol-3-yl)-pyrimidin-2-yloxy]-naphthalen-2-ylmethyl}-piperidin-4-ol; 1-{6-[5-(2H-Pyrazol-3-yl)-pyrimidin-2-yloxy]-naphthalen-2-ylmethyl}-piperidine-4-carboxylic acid amide; N-(1-{6-[5-(2H-Pyrazol-3-yl)-pyrimidin-2-yloxy]-naphthalen-2-ylmethyl}-piperidin-4-yl)-acetamide; (S)-3-Hydroxy-1-(1-{6-[5-(2H-pyrazol-3-yl)-pyrimidin-2-yloxy]-naphthalen-2-ylmethyl}-piperidin-4-yl)-pyrrolidin-2-one; (S)-2-Hydroxy-1-(4-{6-[5-(2H-pyrazol-3-yl)-pyrimidin-2-yloxy]-naphthalen-2-ylmethyl}-piperazin-1-yl)-propan-1-one; 2-Hydroxy-N-methyl-N-(1-{6-[5-(2H-pyrazol-3-yl)-pyrimidin-2-yloxy]-naphthalen-2-ylmethyl}-piperidin-4-yl)-acetamide; 1-{3-[(Methyl-{6-[5-(2H-pyrazol-3-yl)-pyrimidin-2-yloxy]-naphthalen-2-ylmethyl}-amino)-methyl]-azetidin-1-yl}-ethanone; 3-(1-{6-[5-(2H-Pyrazol-3-yl)-pyrimidin-2-yloxy]-naphthalen-2-ylmethyl}-piperidin-4-yl)-oxazolidin-2-one; 4-{6-[5-(2H-Pyrazol-3-yl)-pyrimidin-2-yloxy]-naphthalen-2-ylmethyl}-piperazine-1-carboxylic acid dimethylamide; 2,2-Dimethyl-1-(4-{6-[5-(2H-pyrazol-3-yl)-pyrimidin-2-yloxy]-naphthalen-2-ylmethyl}-piperazin-1-yl)-propan-1-one; 1-(1-{6-[5-(2H-Pyrazol-3-yl)-pyrimidin-2-yloxy]-naphthalen-2-ylmethyl}-piperidin-4-yl)-pyrrolidin-2-one; 1-(4-{6-[5-(2H-Pyrazol-3-yl)-pyrimidin-2-yloxy]-naphthalen-2-ylmethyl}-piperazin-1-yl)-propan-1-one; 1-{6-[5-(2H-Pyrazol-3-yl)-pyrimidin-2-yloxy]-naphthalen-2-ylmethyl}-piperidine-4-carboxylic acid dimethylamide; 2-Hydroxy-2-methyl-1-(4-{6-[5-(2H-pyrazol-3-yl)-pyrimidin-2-yloxy]-naphthalen-2-ylmethyl}-piperazin-1-yl)-propan-1-one; Cyclopropyl-(4-{6-[5-(2H-pyrazol-3-yl)-pyrimidin-2-yloxy]-naphthalen-2-ylmethyl}-piperazin-1-yl)-methanone; 2-Methyl-1-(4-{6-[5-(2H-pyrazol-3-yl)-pyrimidin-2-yloxy]-naphthalen-2-ylmethyl}-piperazin-1-yl)-propan-1-one; (R)-1-{6-[5-(2H-Pyrazol-3-yl)-pyrimidin-2-yloxy]-naphthalen-2-ylmethyl}-pyrrolidin-3-ol; (S)-1-{6-[5-(2H-Pyrazol-3-yl)-pyrimidin-2-yloxy]-naphthalen-2-ylmethyl}-pyrrolidin-3-ol; 3-Methyl-1-{6-[5-(2H-pyrazol-3-yl)-pyrimidin-2-yloxy]-naphthalen-2-ylmethyl}-azetidin-3-ol; 2-Hydroxy-1-(4-{6-[5-(2H-pyrazol-3-yl)-pyrimidin-2-yloxy]-naphthalen-2-ylmethyl}-piperazin-1-yl)-ethanone; and 1-{6-[5-(2H-Pyrazol-3-yl)-pyrimidin-2-yloxy]-naphthalen-2-ylmethyl}-azetidin-3-ol; (S)-3-Hydroxy-1-(1-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-quinolin-2-ylmethyl}-piperidin-4-yl)-pyrrolidin-2-one; (R)-2-Methoxy-1-(8-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-quinolin-2-ylmethyl}-3,8-diaza-bicyclo[3.2.1]oct-3-yl)-propan-1-one; (S)-2-Methoxy-1-(8-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-quinolin-2-ylmethyl}-3,8-diaza-bicyclo[3.2.1]oct-3-yl)-propan-1-one; (S)-2-Hydroxy-1-(8-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-quinolin-2-ylmethyl}-3,8-diaza-bicyclo[3.2.1]oct-3-yl)-propan-1-one; 2-Hydroxy-2-methyl-1-(8-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-quinolin-2-ylmethyl}-3,8-diaza-bicyclo[3.2.1]oct-3-yl)-propan-1-one; (R)-2-Hydroxy-1-(8-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-quinolin-2-ylmethyl}-3,8-diaza-bicyclo[3.2.1]oct-3-yl)-propan-1-one; 2-Methoxy-1-(8-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-quinolin-2-ylmethyl}-3,8-diaza-bicyclo[3.2.1]oct-3-yl)-ethanone; 2-Hydroxy-N-methyl-N-((R)-1-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-quinolin-2-ylmethyl}-pyrrolidin-3-yl)-acetamide; 2-Hydroxy-N-methyl-N-((S)-1-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-quinolin-2-ylmethyl}-pyrrolidin-3-yl)-acetamide; 2-Hydroxy-1-[(R)-3-(methyl-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-quinolin-2-ylmethyl}-amino)-pyrrolidin-1-yl]-ethanone; 2-Hydroxy-1-[(S)-3-(methyl-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-quinolin-2-ylmethyl}-amino)-pyrrolidin-1-yl]-ethanone; 2-Hydroxy-1-(7-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-quinolin-2-ylmethyl}-2,7-diaza-spiro[4.4]non-2-yl)-ethanone; (S)-2-Methoxy-1-(4-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-quinolin-2-ylmethyl}-piperazin-1-yl)-propan-1-one; (R)-2-Hydroxy-1-(4-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-quinolin-2-ylmethyl}-piperazin-1-yl)-propan-1-one; (1-Hydroxy-cyclopropyl)-(4-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-quinolin-2-ylmethyl}-piperazin-1-yl)-methanone; 2-Methoxy-2-methyl-1-(4-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-quinolin-2-ylmethyl}-piperazin-1-yl)-propan-1-one; (S)-2-Hydroxy-1-(4-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-quinolin-2-ylmethyl}-piperazin-1-yl)-propan-1-one; (R)-2-Methoxy-1-(4-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-quinolin-2-ylmethyl}-piperazin-1-yl)-propan-1-one; and 2-Methyl-3-oxo-3-(4-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-quinolin-2-ylmethyl}-piperazin-1-yl)-propionitrile; 1-{6-[5-(2H-Pyrazol-3-yl)-pyridin-2-yloxy]-naphthalen-2-ylmethyl}-azetidin-3-ol; 1-{6-[5-(2H-Pyrazol-3-yl)-pyridin-2-yloxy]-naphthalen-2-ylmethyl}-azetidine-3-carboxylic acid amide; N-(1-{6-[5-(2H-Pyrazol-3-yl)-pyridin-2-yloxy]-naphthalen-2-ylmethyl}-azetidin-3-yl)-acetamide; (1-{6-[5-(2H-Pyrazol-3-yl)-pyridin-2-yloxy]-naphthalen-2-ylmethyl}-azetidin-3-yl)-methanol; (S)-1-{6-[5-(2H-Pyrazol-3-yl)-pyridin-2-yloxy]-naphthalen-2-ylmethyl}-pyrrolidin-3-ol; (R)-1-{6-[5-(2H-Pyrazol-3-yl)-pyridin-2-yloxy]-naphthalen-2-ylmethyl}-pyrrolidin-3-ol; 2-Hydroxy-1-(4-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-naphthalen-2-ylmethyl}-piperazin-1-yl)-ethanone; 2-Hydroxy-N-(1-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-naphthalen-2-ylmethyl}-piperidin-4-yl)-acetamide; 2-{6-[5-(2H-Pyrazol-3-yl)-pyridin-2-yloxy]-naphthalen-2-ylmethyl}-2-aza-spiro[3.3]heptan-6-ol; 3-Methyl-1-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-naphthalen-2-ylmethyl}-azetidin-3-ol; N-((R)-1-{6-[5-(2H-Pyrazol-3-yl)-pyridin-2-yloxy]-naphthalen-2-ylmethyl}-pyrrolidin-3-yl)-acetamide; N-((S)-1-{6-[5-(2H-Pyrazol-3-yl)-pyridin-2-yloxy]-naphthalen-2-ylmethyl}-pyrrolidin-3-yl)-acetamide; (S)-1-{6-[5-(2H-Pyrazol-3-yl)-pyridin-2-yloxy]-naphthalen-2-ylmethyl}-piperidin-3-ol; (R)-1-{6-[5-(2H-Pyrazol-3-yl)-pyridin-2-yloxy]-naphthalen-2-ylmethyl}-piperidin-3-ol; 2-(Methyl-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-naphthalen-2-ylmethyl}-amino)-ethanol; (1-{6-[5-(2H-Pyrazol-3-yl)-pyridin-2-yloxy]-naphthalen-2-ylmethyl}-piperidin-4-yl)-methanol; ((S)-1-{6-[5-(2H-Pyrazol-3-yl)-pyridin-2-yloxy]-naphthalen-2-ylmethyl}-pyrrolidin-3-yl)-methanol; 2-Hydroxy-1-[(R)-3-(methyl-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-naphthalen-2-ylmethyl}-amino)-pyrrolidin-1-yl]-ethanone; 2-Hydroxy-N-methyl-N-((S)-1-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-naphthalen-2-ylmethyl}-pyrrolidin-3-yl)-acetamide; 2-Hydroxy-N-methyl-N-((R)-1-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-naphthalen-2-ylmethyl}-pyrrolidin-3-yl)-acetamide; ((R)-1-{6-[5-(2H-Pyrazol-3-yl)-pyridin-2-yloxy]-naphthalen-2-ylmethyl}-pyrrolidin-3-yl)-methanol; and 2-Hydroxy-1-[(S)-3-(methyl-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-naphthalen-2-ylmethyl}-amino)-pyrrolidin-1-yl]-ethanone; 1-(1-{(R)-6-[5-(2H-Pyrazol-3-yl)-pyridin-2-yloxy]-2,3-dihydro-benzofuran-2-ylmethyl}-piperidin-4-yl)-pyrrolidin-2-one; 1-(1-{(S)-6-[5-(2H-Pyrazol-3-yl)-pyridin-2-yloxy]-2,3-dihydro-benzofuran-2-ylmethyl}-piperidin-4-yl)-pyrrolidin-2-one; 1-[1-(2-{6-[5-(2H-Pyrazol-3-yl)-pyridin-2-yloxy]-benzofuran-3-yl}-ethyl)-piperidin-4-yl]-pyrrolidin-2-one; (S)-3-Hydroxy-1-[1-(2-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-benzofuran-3-yl}-ethyl)-piperidin-4-yl]-pyrrolidin-2-one; 2-Methoxy-1-[4-(2-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-benzofuran-3-yl}-ethyl)-piperazin-1-yl]-ethanone; (R)-2-Methoxy-1-[4-(2-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-benzofuran-3-yl}-ethyl)-piperazin-1-yl]-propan-1-one; 1-(4-{6-[5-(2H-Pyrazol-3-yl)-pyridin-2-yloxy]-benzofuran-3-ylmethyl}-[1,4]diazepan-1-yl)-ethanone; 1-{6-[5-(2H-Pyrazol-3-yl)-pyridin-2-yloxy]-benzofuran-3-ylmethyl}-piperidine-4-carboxylic acid methylamide; N-(1-{6-[5-(2H-Pyrazol-3-yl)-pyridin-2-yloxy]-benzofuran-3-ylmethyl}-piperidin-4-yl)-acetamide; N-(1-{6-[5-(2H-Pyrazol-3-yl)-pyridin-2-yloxy]-benzofuran-3-ylmethyl}-piperidin-4-yl)-methanesulfonamide; N-(1-{6-[5-(2H-Pyrazol-3-yl)-pyridin-2-yloxy]-benzofuran-3-ylmethyl}-piperidin-4-ylmethyl)-acetamide; 1-{4-[({6-[5-(2H-Pyrazol-3-yl)-pyridin-2-yloxy]-benzofuran-3-ylmethyl}-amino)-methyl]-piperidin-1-yl}-ethanone; 1-[4-({6-[5-(2H-Pyrazol-3-yl)-pyridin-2-yloxy]-benzofuran-3-ylmethyl}-amino)-piperidin-1-yl]-ethanone; (S)-3-Hydroxy-1-(1-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-benzofuran-3-ylmethyl}-piperidin-4-yl)-pyrrolidin-2-one; 2-Methyl-8-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-benzofuran-3-ylmethyl}-2,8-diaza-spiro[4.5]decan-1-one; 2-(4-{6-[5-(2H-Pyrazol-3-yl)-pyridin-2-yloxy]-benzofuran-3-ylmethyl}-piperazin-1-yl)-1-pyrrolidin-1-yl-ethanone; 2-Hydroxy-N-methyl-N-((R)-1-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-benzofuran-3-ylmethyl}-pyrrolidin-3-yl)-acetamide; 2-Hydroxy-N-methyl-N-((S)-1-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-benzofuran-3-ylmethyl}-pyrrolidin-3-yl)-acetamide; and 2-Hydroxy-1-(7-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-yloxy]-benzofuran-3-ylmethyl}-2,7-diaza-spiro[4.4]non-2-yl)-ethanone; or a pharmaceutically acceptable salt thereof.