Patent ID: 9549907
Date: 2017-01-24
CPC Classifications: A61K

Claim:
1. An immediate release solution for the oral administration of guaifenesin, wherein the solution comprises hydrocodone and/or a pharmaceutically acceptable salt thereof as additional drug and as solvents water and a total of from 48% to 72% by weight, relative to a total weight of the solution, of propylene glycol and glycerol, and wherein the solution, when orally administered to an adult human subject as a single dose in an amount which affords 200 mg of guaifenesin, provides (i) a C max of at least 3600 ng/mL of guaifenesin and/or an AUC (0-inf) of guaifenesin of at least 3700 ng·hr/mL and (ii) a therapeutically effective plasma concentration of guaifenesin for at least 4 hours.