Patent ID: 9556259
Date: 2017-01-31
CPC Classifications: A61K,A61P,C07K,G01N

Claim:
1. A method of treating a patient having or at risk of a synucleinopathy, comprising administering to the patient an effective regime of an antibody that binds alpha synuclein, the antibody comprising a humanized heavy chain comprising the three Kabat CDRs of SEQ ID NO:11 and a humanized light chain comprising the three Kabat CDRs of SEQ ID NO:4, provided that position L36 (Kabat numbering) is occupied by F and/or position L83 (Kabat numbering) is occupied by L and/or position H73 (Kabat numbering) is occupied by D, and/or position H93 (Kabat numbering) is occupied by S; wherein a patient at risk of a synucleinopathy has a risk factor conferring a statistically significant risk of developing the synucleinopathy compared with subjects lacking the risk factor.