Patent ID: 9617265
Date: 2017-04-11
CPC Classifications: A61K,A61P,C07B,C07D

Claim:
1. A method of treating a patient to alleviate nociceptive pain in the absence of a treatment of drug dependence or drug abuse and in the absence of any concomitant opioid analgesic therapy, comprising: administering systemically to said patient a pharmaceutical composition comprising an effective-amount of a noribogaine salt selected from: a pharmaceutically acceptable salt of noribogaine ansolvate, which is amorphous or is a crystalline hydrochloride salt having an X-ray powder diffraction pattern comprising peaks at 11.6±0.2° 2θ, 12.1±0.2° 2θ, 13.5±0.2° 2θ, 13.9±0.2° 2θ, 14.9±0.2° 2θ, 15.7±0.2° 2θ, 17.1±0.2° 2θ, 17.9±0.2° 2θ, 18.3±0.2° 2θ, 19.8±0.2° 2θ, 20.8±0.2°, 21.0±0.2° 2θ, 21.9±0.2° 2θ, 22.8±0.2° 2θ, 23.3±0.2° 2θ, 24.9±0.2° 2θ, 25.9±0.2°, 26.4±0.2° 2θ, 29.3±0.2° 2θ and 29.8±0.2° 2θ as shown in a crystalline noribogaine hydrochloride solvate polymorph having an X-ray powder diffraction pattern comprising peaks at 9.7±0.2° 2θ, 10.2±0.2° 2θ, 12.0±0.2° 2θ, 13.3±0.2° 2θ, 13.7±0.2° 2θ, 16.0±0.2° 2θ, 16.3±0.2° 2θ, 17.7±0.2° 2θ, 18.0±0.2° 2θ, 19.4±0.2° 2θ, 21.4±0.2° 2θ, 22.1±0.2° 2θ, 22.8±0.2° 2θ, 24.4±0.2° 2θ and 25.1±0.2° 2θ as shown in a crystalline polymorph of a phosphate salt of noribogaine, having an X-ray powder diffraction pattern comprising peaks as shown in to said patient effective to reduce or eliminate said nociceptive pain in said patient.