Patent ID: 9549896
Date: 2017-01-24
CPC Classifications: A61K,A61P,Y02A

Claim:
1. A bioerodible patch comprising at least one bioadhesive layer and at least one non-bioadhesive layer, wherein the bioadhesive layer is a dry film, comprises a mixture of at least one polyaphron dispersion and at least one bioadhesive polymer, and is prepared such that when the patch is placed on the mucosa at least 50% by weight of the bioadhesive layer disintegrates within 20 minutes, wherein the non-bioadhesive layer comprises about 5% to about 99% of the patch by weight, wherein the polyaphron dispersion comprises at least one pharmaceutically active agent, a continuous phase and a discontinuous phase, wherein the discontinuous phase comprises a pharmaceutically acceptable oil phase, wherein the bioadhesive layer comprises from 10 to 50% by weight of pharmaceutically acceptable oil, from 10 to 70% by weight of bioadhesive polymer, and 5 to 30% by weight of plasticizer, wherein at least one of the at least one pharmaceutically active agent is poorly water-soluble, wherein the poorly water-soluble pharmaceutically active agent will only dissolve in water in an amount of less than 1% by weight, wherein the amount of polyaphron dispersion in the bioadhesive layer is at most 60% by weight of the total bioadhesive layer, the volume fraction of the dispersed phase of the polyaphron dispersion is from 0.7 to 0.97, and wherein the polyaphron dispersion is adapted to release individual droplets of the discontinuous phase when the patch disintegrates within a buccal cavity.