Patent ID: 9718793
Date: 2017-08-01
CPC Classifications: A61K,A61P,C07D

Claim:
1. A method of inhibiting Heat Shock Protein 90 (HSP90) activity in mammals comprising administering to the mammal an amount of a compound of formula (A) or (B) or a salt, N-oxide, hydrate or solvate thereof, or a prodrug thereof effective to inhibit HSP90 activity: wherein R wherein in any compatible combination R represents one or more optional substituents, Alk p, r and s are independently 0 or 1, Z is —O—, —S—, —(C═O )—, —(C═S)—, —SO —C(═S)NR Q is hydrogen or an optionally substituted carbocyclic or heterocyclic radical; R wherein in any compatible combination Ar Alk (ii) a carboxamide radical; or (iii) a non aromatic carbocyclic or heterocyclic ring wherein a ring carbon is optionally substituted, and/or a ring nitrogen is optionally substituted by a group of formula —(Alk R