Patent ID: 9549973
Date: 2017-01-24
CPC Classifications: A61K,A61P,C07K,C12N,C12Y

Claim:
1. A method of inducing an anti-KLK3 immune response in a subject, comprising administering to said subject a composition comprising a recombinant Listeria strain encoding a recombinant fusion peptide consisting of a KLK3 peptide operatively linked to a non-KLK3 peptide, wherein said non-KLK3 peptide is a N-terminal non-hemolytic listeriolysin (LLO) peptide, said fusion peptide consisting of the sequence of SEQ ID NO: 54 or a sequence at least 99% homologous (throughout the length of the peptide) thereto, wherein said N-terminal LLO peptide enhances the immunogenicity of the fusion peptide, thereby inducing an anti-KLK3 immune response in a subject.