Patent ID: 9587027
Date: 2017-03-07
CPC Classifications: A61P,C07K

Claim:
1. A method of inhibiting IL-4 induced cell proliferation in vitro, comprising contacting cells expressing human IL-4 receptor alpha (IL-4Rα) with an isolated antibody or fragment thereof that specifically binds hIL-4Rα, the isolated antibody or fragment thereof comprising a set of CDRs, wherein: (i) the HCDR1 has amino acid sequence SEQ ID NO: 193; the HCDR2 has amino acid sequence SEQ ID NO: 194; the HCDR3 has amino acid sequence SEQ ID NO: 195; the LCDR1 has amino acid sequence SEQ ID NO: 198; the LCDR2 has amino acid sequence SEQ ID NO: 199; and the LCDR3 has amino acid sequence SEQ ID NO: 200; or (ii) the HCDR1 has the amino acid sequence SEQ ID NO: 363; the HCDR2 has the amino acid sequence SEQ ID NO: 364; the HCDR3 has the amino acid sequence SEQ ID NO: 365; the LCDR1 has the amino acid sequence SEQ ID NO: 368; the LCDR2 has the amino acid sequence SEQ ID NO: 369; and the LCDR3 has the amino acid sequence SEQ ID NO: 370; or (iii) the HCDR1 has the amino acid sequence SEQ ID NO: 233; the HCDR2 has the amino acid sequence SEQ ID NO: 234; the HCDR3 has the amino acid sequence SEQ ID NO: 235; the LCDR1 has the amino acid sequence SEQ ID NO: 238; the LCDR2 has the amino acid sequence SEQ ID NO: 239; and the LCDR3 has the amino acid sequence SEQ ID NO: 240.