Patent ID: 9724362
Date: 2017-08-08
CPC Classifications: A61K,A61P

Claim:
1. A solid pharmaceutical composition comprising: (a) nanoparticles comprising a poorly water soluble drug distributed throughout a poorly aqueous soluble polymer selected from the group consisting of ethylcellulose, propylcellulose, butylcellulose, cellulose acetate, cellulose propionate, cellulose butyrate, cellulose acetate propionate, cellulose acetate butyrate, methyl cellulose acetate, methyl cellulose propionate, methyl cellulose butyrate, ethyl cellulose acetate, ethyl cellulose propionate, ethyl cellulose butyrate, low-substituted hydroxypropyl cellulose, hydroxypropyl methylcellulose acetate, hydroxypropyl methylcellulose propionate, hydroxypropyl methylcellulose butyrate, poly(vinyl acetate-co-vinyl alcohol), poly(ethylene-co-vinyl acetate), poly(ethyl acrylate-co-methyl methacrylate), poly(lactide), poly(glycolide), poly(E-caprolactone), poly(lactide-co-glycolide), poly(lactide-co-E-caprolactone), poly(ethylene oxide-co-E-caprolactone), poly(ethylene oxide-co-lactide), poly(ethylene oxide-colactide-co-glycolide, poly(isobutyl)cyanoacrylate, and poly(hexyl)cyanoacrylate, wherein (b) a resuspending material selected from the group consisting of hydroxypropyl methyl cellulose acetate succinate, carboxymethyl ethylcellulose, and pharmaceutically acceptable salt forms thereof; wherein said resuspending material constitutes from 5 wt % to 90 wt % of the combined mass of (1) said resuspending material and (2) said nanoparticles, and wherein said composition comprises particles comprising said nanoparticles distributed throughout said resuspending material.