Patent ID: 9556487
Date: 2017-01-31
CPC Classifications: A61P,C12Q

Claim:
1. A method for treating Mild Cognitive Impairment (MCI) or pre-MCI in a subject without clinical symptoms of dementia, which method comprises: a. measuring the level of a synapse or neurite miRNA selected from the group consisting of miR-128, miR-132, miR-874, miR-134, miR-323-3p, and miR-382 in a bodily fluid sample collected from the subject, wherein the bodily fluid is selected from the group consisting of blood plasma, serum, urine, and saliva; b. measuring the level of a normalizer miRNA selected from the group consisting of miR-9, miR-181a, miR-127, miR-370, and miR-491-5p in the same bodily fluid sample collected from the subject; c. calculating the ratio of the levels of the miRNAs measured in steps (a) and (b), d. comparing the ratio of the levels of the miRNAs calculated in step (c) with a corresponding age-matched control ratio, and e. administering a therapeutic or preventive treatment for neurodegeneration to the subject prior to appearance of clinical symptoms of dementia in said subject when the ratio of the levels of the miRNAs calculated in step (c) is greater than the corresponding age-matched control ratio.