Patent ID: 9556220
Date: 2017-01-31
CPC Classifications: A61P,C07J

Claim:
1. Process for the preparation of drospirenone (I) comprising the single-step conversion of a compound selected from 17α-(3-hydroxypropyl)-6β,7β,15β,16β-dimethylen-5β-androstan-3β,5,17β-triol (II), alone or in a mixture with its lactols, and 3β,5-dihydroxy-6β,7β;15β,16β-dimethylen-5β,17α-pregna-21,17-carbolactone (III): using oxygen gas in the presence of a palladium compound having the +2 oxidation state, an organic base and molecular sieves in an organic solvent inert under the reaction conditions, at a temperature between 60 and 140° C.