Patent ID: 9732080
Date: 2017-08-15
CPC Classifications: A61K,A61P,C07D

Claim:
1. A method of increasing CFTR transporters in a membrane of a cell, comprising the step of contacting said cell with a compound according to formula I: or a pharmaceutically acceptable salt thereof, wherein: Ar wherein each of G Ar Ar R ring A is 3-7 membered monocyclic ring; ring B is optionally fused to a 5-7 membered ring selected from cycloaliphatic, aryl, heterocyclic, and heteroaryl, wherein ring B, together with said optionally fused ring, is optionally substituted with x occurrences of —XR W or X is independently a bond or a (C1-C6) alkylidene chain wherein up to two methylene units of W or X are optionally replaced by —O—; each R R wherein n is 0 or 1; and Y is halo, OH, or OR two R wherein J is selected from CH R R R w is 0 to 5; and x is 0-5.