Patent ID: 9689786
Date: 2017-06-27
CPC Classifications: G01N

Claim:
1. Method for determining the size distribution of a mixture of molecule or particle species comprising the following steps: injecting a sample of the mixture to be analyzed inside a capillary in which an eluent is flowing; transporting the sample injected along the capillary from an injection section to a detection section thereof, in experimental conditions suitable to generate a Taylor dispersion phenomenon that is measurable at the level of the detection section; generating, by means of a suitable sensor included in the detection section, a signal characteristic of the Taylor dispersion of the transported sample; processing the detection signal in order to obtain an experimental Taylor signal Ŝ(t); and analyzing the experimental Taylor signal Ŝ(t), wherein the step of analyzing an experimental Taylor signal Ŝ(t) of a sample of the mixture consists of searching an amplitude distribution P(G where t is a variable upon which the experimental Taylor signal depends and t G where c=1, with the diffusion coefficient D of a species according to the relation for c=−1, to the hydrodynamic ray R and for c=−1/d where k by implementing a constrained regularization algorithm consisting of minimizing a cost function H