Patent ID: 9555134
Date: 2017-01-31
CPC Classifications: A61K,B82Y

Claim:
1. A contrast agent for magnetic resonance imaging comprising: nanoparticles, wherein said nanoparticles comprise: a polymer support; and a manganese-iron-oxo cluster of formula II: formula III: wherein R is selected from the group consisting of alkyl, vinyl, halo, oxy, and oxyalkyl; wherein the nanoparticles of the present invention are from about 5 to about 1000 nm in diameter; and wherein (i) the polymer support is a carboxylate-coated polymeric bead comprising styrene, vinyl benzoic acid, vinyl alcohol, or a co-polymer thereof and the clusters are bonded to the surface of the carboxylate-coated polymeric bead, or (ii) the polymer support is a co-polymer comprising (a) styrene, vinyl benzoic acid, or vinyl alcohol, and (b) the clusters.