Patent ID: 9682157
Date: 2017-06-20
CPC Classifications: A61K

Claim:
1. A magnetic resonance imaging agent comprising: (a) a superparamagnetic core; (b) a linker group; and (c) a pH sensitive macromolecule comprising a monomer unit comprising a dendron and having a pKa between 6 and 10; wherein, the linker group is affixed to the superparamagnetic core; the pH sensitive macromolecule is attached to the linker group; the dendron comprises a melamine, an imidazole, a polyimidazole, a vinyl imidazole, a nitrilotriacetic acid, a polyethylene glycol (PEG), a histidine, a lysine, an amino carboxylate, a histidine-lysine, or an amino sulfonate; the imaging agent exhibits a pH sensitive magnetic resonance response; and the imaging agent is biocompatible.