Patent ID: 9575081
Date: 2017-02-21
CPC Classifications: B01L,G01N

Claim:
1. A microfluidic device for detecting the presence of one or more analytes in a saliva sample, comprising: (a) one or more pre-treatment chambers comprising a pre-treatment non-porous surface with hydroxyapatite bound as a first molecule capable of specifically or non-specifically binding to one or more saliva components in the saliva sample interfering with the detection of the one or more analytes to thereby specifically or non-specifically remove at least a part of the one or more saliva components in the saliva sample interfering with detection of the one or more analytes; and (b) a detection chamber separate from and fluidically coupled to the one or more pre-treatment chambers and comprising a biosensor surface, the biosensor surface comprising:  second molecules capable of specifically binding the one or more analytes; or  the one or more analytes and/or second molecules which are structurally related to the analyte and bind analyte-specific probes.