Patent ID: 9678060
Date: 2017-06-13
CPC Classifications: A61P,G01N

Claim:
1. A method for screening a test compound for anti-neoplastic activity, the method comprising: providing a test compound, providing a cell, measuring and quantifying the degree of increase in the acetylation of Lysine 16 of the N-terminal tail of histone H4, exposing the cell to the test compound, and re-measuring the acetylation of Lysine 16 of the N-terminal tail of histone H4 in the cell, wherein the method further comprises measuring the expression of UGT1A and THBS, both before and after exposure to the test compound, wherein a two-fold increase in acetylation of Lysine 16 of the N-terminal tail of histone H4, together with an increased level of expression of UGT1A and THBS corresponds to the classification of the test compound as putatively having anti-neoplastic activity.