Patent ID: 9694050
Date: 2017-07-04
CPC Classifications: A61K,C07K,C12N

Claim:
1. A method of inhibiting adipogenesis and/or decreasing adipocyte size in a subject having obesity, the method comprising: selecting a subject having obesity and administering to the selected subject a composition comprising an isolated and substantially pure Thy1 protein or polypeptide fragment thereof comprising the amino acid sequence of (i) amino acids 20-130 of SEQ ID NO: 1 or (ii) amino acids 20-130 of SEQ ID NO: 1 having one or more additions, substitutions, or deletions at amino acids corresponding to amino acids 42, 79, and/or 119 of SEQ ID NO: 1, wherein the Thy1 protein or polypeptide fragment inhibits PPAR-gamma activity and/or promotes ERK signaling in multipotent stromal cells to inhibit adipogenesis and/or decrease adipocyte size in the selected subject.