Patent ID: 9636398
Date: 2017-05-02
CPC Classifications: A61K,A61P,C07K,G01N

Claim:
1. An isolated antibody or antigen-binding fragment thereof, wherein the antibody or antigen-binding fragment thereof comprises a domain or region selected from the group consisting of: (a) a variable heavy domain region comprising the amino acid sequence of SEQ ID NO:43, (b) a variable light domain region comprising the amino acid sequence of SEQ ID NO:47, (c) a variable heavy domain region comprising the amino acid sequence of SEQ ID NO:51, (d) a variable light domain region comprising the amino acid sequence of SEQ ID NO:55, (e) a variable heavy domain region comprising the amino acid sequence of SEQ ID NO:59, (f) a variable light domain region comprising the amino acid sequence of SEQ ID NO:63, (g) a variable heavy domain region comprising the amino acid sequence of SEQ ID NO:67, (h) a variable light domain region comprising the amino acid sequence of SEQ ID NO:71, (i) a variable heavy domain region comprising the amino acid sequence of SEQ ID NO:75, (j) a variable light domain region comprising the amino acid sequence of SEQ ID NO:79; (k) a variable heavy domain region comprising the amino acid sequence of SEQ ID NO:94; (l) a variable light domain region comprising the amino acid sequence of SEQ ID NO:98; (m) a variable heavy domain region comprising the amino acid sequence of SEQ ID NO:43 and a variable light domain region comprising the amino acid sequence of SEQ ID NO:47, (n) a variable heavy domain region comprising the amino acid sequence of SEQ ID NO:51 and a variable light domain region comprising the amino acid sequence of SEQ ID NO:55, (o) a variable heavy domain region comprising the amino acid sequence of SEQ ID NO:59 and a variable light domain region comprising the amino acid sequence of SEQ ID NO:63, (p) a variable heavy domain region comprising the amino acid sequence of SEQ ID NO:67 and a variable light domain region comprising the amino acid sequence of SEQ ID NO:71, (q) a variable heavy domain region comprising the amino acid sequence of SEQ ID NO:75 and a variable light domain region comprising the amino acid sequence of SEQ ID NO:79, (r) a variable heavy domain region comprising the amino acid sequence of SEQ ID NO:94 and a variable light domain region comprising the amino acid sequence of SEQ ID NO:98, (s) a variable heavy chain a comprising complementarity determining region (CDR)1comprising the amino acid sequence of SEQ ID NO:44, a CDR2 comprising the amino acid sequence of SEQ ID NO:45, and a CDR3 comprising the amino acid sequence of SEQ ID NO:46 and a variable light chain comprising a CDR1 comprising the amino acid sequence of SEQ ID NO:48, a CDR2 comprising the amino acid sequence of SEQ ID NO:49, and a CDR3 comprising the amino acid sequence of SEQ ID NO:50, (t) a variable heavy chain comprising a CDR1 comprising the amino acid sequence of SEQ ID NO:52, a CDR2 comprising the amino acid sequence of SEQ ID NO:53, and a CDR3 comprising the amino acid sequence of SEQ ID NO:54 and a variable light chain comprising a CDR1 comprising the amino acid sequence of SEQ ID NO:56, a CDR2 comprising the amino acid sequence of SEQ ID NO:57, and a CDR3 comprising the amino acid sequence of SEQ ID NO:58, (u) a variable heavy chain comprising a CDR1 comprising the amino acid sequence of SEQ ID NO:60, a CDR2 comprising the amino acid sequence of SEQ ID NO:61, and a CDR3 comprising the amino acid sequence of SEQ ID NO:62 and a variable light chain comprising a CDR1 comprising the amino acid sequence of SEQ ID NO:64, a CDR2 comprising the amino acid sequence of SEQ ID NO:65, and a CDR3 comprising the amino acid sequence of SEQ ID NO:66, (v) a variable heavy chain comprising a CDR1 comprising the amino acid sequence of SEQ ID NO:68, a CDR2 comprising the amino acid sequence of SEQ ID NO:69, and a CDR3 comprising the amino acid sequence of SEQ ID NO:70 and a variable light chain comprising a CDR1 comprising the amino acid sequence of SEQ ID NO:72, a CDR2 comprising the amino acid sequence of SEQ ID NO:73, and a CDR3 comprising the amino acid sequence of SEQ ID NO:74, (w) a variable heavy chain comprising a CDR1 comprising the amino acid sequence of SEQ ID NO:76, a CDR2 comprising the amino acid sequence of SEQ ID NO:77, and a CDR3 comprising the amino acid sequence of SEQ ID NO:78 and a variable light chain comprising a CDR1 comprising the amino acid sequence of SEQ ID NO:80, a CDR2 comprising the amino acid sequence of SEQ ID NO:81, and a CDR3 comprising the amino acid sequence of SEQ ID NO:82, and (x) a variable heavy chain comprising a CDR1 comprising the amino acid sequence of SEQ ID NO:95, a CDR2 comprising the amino acid sequence of SEQ ID NO:96, and a CDR3 comprising the amino acid sequence of SEQ ID NO:97, and a variable light chain comprising a CDR1 comprising the amino acid sequence of SEQ ID NO:99, a CDR2 comprising the amino acid sequence of SEQ ID NO:100, and a CDR3 comprising the amino acid sequence of SEQ ID NO:101, wherein the antibody or antigen-binding fragment thereof specifically binds to Repulsive Guidance Molecule c (“RGMc”).