Patent ID: 9730961
Date: 2017-08-15
CPC Classifications: A61K,A61P,C07K,C12N

Claim:
1. A method of treating a disease or disorder of the eye in a patient, comprising: administering to said patient mesenchymal stem cells which have been cultured in a medium containing tumor necrosis factor-α (TNF-α), and under conditions to express an increased amount of tumor necrosis factor-α stimulating gene 6 (TSG-6) protein or a biologically active fragment, derivative, or analogue thereof, compared to the amount of said TSG-6 protein or biologically active fragment, derivative, or analogue thereof expressed by an otherwise identical population of mesenchymal stem cells which have not been cultured in a medium containing TNF-α, and under conditions to express an increased amount of said TSG-6 protein or biologically active fragment, derivative, or analogue thereof, wherein said mesenchymal stem cells are administered in an amount effective to treat or prevent said disease or disorder of the eye in said patient.