Patent ID: 9604914
Date: 2017-03-28
CPC Classifications: C07C,C07D

Claim:
1. A process for preparing a compound of the following formula: comprising reacting a compound of the formula wherein X 2 is bromo, chloro, iodo, mesylate, tosylate, triflate or another suitable leaving group, with the compound of formula in the presence of a strong base, wherein the starting material of formula IX is synthesized comprising the steps of: (a) reacting a compound of the formula wherein X is chloro, bromo, or iodo, with a Grignard reagent to form the compound of the formula (b) reacting the compound of formula Ill with strong acid to form the compound of formula (c) subjecting the compound of formula IV to catalytic hydration to form the compound of formula (d) converting the compound of formula V into a compound of the formula wherein X 1 is bromo, chloro or iodo, by reacting the compound of formula V with 1,3-dibromyl-5,5-diethylhydantoin when X 1 in formula VI is bromo, or by reacting the compound of formula V with the appropriate analogous compound when X 1 is chloro, fluoro or iodo, in the presence of an acid; (e) reacting the compound of formula VI with a Grignard reagent and carbon dioxide to form the compound of formula or, alternatively, when carrying out the above reaction of step “e”, adding dimethylformamide to the Grignard reagent to form the corresponding aldehyde of formula (f) reducing the compound of formula VII or VIIA to form the compound of formula (g) reacting the compound of formula VIII with the appropriate compound of the formula HX