Patent ID: 9737728
Date: 2017-08-22
CPC Classifications: A61K,A61N,A61P

Claim:
1. A method of treating mammalian skin tissues for causing a predetermined physiological change in the mammalian skin tissues, said method comprising: applying onto the mammalian skin tissues a treatment composition of matter; defining a plurality of pulse trains, each pulse train including a plurality of radiation pulses having a predetermined pulse duration; separating the plurality of radiation pulses by an inter-pulse interval, at least one of the inter-pulse intervals being of from about 100 microseconds to about 0.5 milliseconds, at least one of the radiation pulses having a power density of 30 mW/cm separating the pulse trains by an inter-pulse train interval, the inter-pulse train interval being substantially larger than the inter-pulse interval, at least two of the pulse trains being separated by an inter-pulse train interval of about 500 microseconds to about 2.25 milliseconds; and irradiating the mammalian skin tissues with the plurality of pulse trains under non-ablative and non-thermal conditions; wherein the treatment composition of matter includes a photoreactive substance and is applied in an amount sufficient to cause physiological changes within the mammalian skin tissues upon the mammalian skin tissues being irradiated.