Patent ID: 9585875
Date: 2017-03-07
CPC Classifications: A61K,A61P,C07D

Claim:
1. A method for the treatment of a disease associated with the activity of TRPM8, wherein the disease is selected from itch, irritable bowel diseases, cold-induced and/or exacerbated respiratory disorders, ischaemia, urological disorders, stroke, psychiatric disorders, neuropathic pain, postoperative pain, cancer pain, rheumatoid arthritic pain, neuralgia, fibromyalgia, neuropathies, fibromyalgia, algesia, nerve injury, migraine, headache, painful bladder syndrome, interstitial cystitis, detrusor overactivity, urinary incontinence, neurogenic detrusor overactivity, idiopathic detrusor overactivity, benign prostatic hyperplasia, lower urinary tract disorders and lower urinary tract symptoms, anxiety, depression and cold-induced/or exacerbated pulmonary hypertension, COPD, and asthma, the method comprising administering to a patient in need thereof a compound having formula I: or a pharmaceutically acceptable salt thereof, wherein: X is selected from S or O; R —OR —NHR R —COOR —OH; —CONH -tetrazol-5-yl or 1-(C -5-(C -5-(C -5-(C R R