Patent ID: 9598460
Date: 2017-03-21
CPC Classifications: A61K,C07K

Claim:
1. A method of binding an immunoglobulin, comprising: providing a small molecule that specifically binds a nucleotide binding site on an immunoglobulin; contacting a composition containing an immunoglobulin with the small molecule under conditions suitable for binding of the immunoglobulin to the small molecule; and separating the small molecule from the composition, wherein the immunoglobulin remains bound to the small molecule: wherein the small molecule is indole 3-butyric acid; and wherein the small molecule has a monovalent K d of about 150 μM or less for a nucleotide binding site defined as: A. phenylalamine 35 of SEQ. ID NO: 1; B. tyrosine 95 of SEQ. ID NO: 3;