Patent ID: 9556426
Date: 2017-01-31
CPC Classifications: A61K,A61P,C07D,C12N

Claim:
1. A protein kinase conjugate that has the formula, wherein, Prot is a human protein kinase or portion thereof comprising a cysteine residue containing amino acid sequence selected from the group consisting of SEQ ID NOs: 1, 6, 7, 8, 9, 26, 27, 28, 29, 30, 31, 32, 33, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, and 45; S—CH M is a modifier moiety that is formed by the covalent bonding of a warhead group with the side chain of said cysteine residue; X is a chemical moiety that binds in or near the ATP binding site of the protein kinase; and wherein the protein kinase conjugate is formed in association with a cell.