Patent ID: 9707213
Date: 2017-07-18
CPC Classifications: A23L,A23V,A61K,A61P

Claim:
1. A method of lowering total cholesterol level or total lipid content in a subject in need thereof, the method comprising administering to the subject a dose of a one or two part composition comprising: a) at least 250 mg of leucine and/or at least 25 mg of one or more leucine metabolites, wherein the leucine metabolite is selected from the group consisting of keto-isocaproic acid (KIC), alpha-hydroxy-isocaproic acid, and hydroxymethylbutyrate (HMB); and b) at least 1 mg of nicotinic acid and/or nicotinamide riboside and/or one or more nicotinic acid metabolites, wherein the nicotinic acid metabolite is selected from the group consisting of nicotinyl CoA, nicotinuric acid, nicotinate mononucleotide, nicotinate adenine dinuecleotide, and nicotinamide adenine dinucleotide, wherein each of (a) and (b) are free of alanine, arginine, asparagine, aspartic acid, cysteine, glutamic acid, glutamine, glycine, histidine, lysine, methionine, phenylalanine, proline, serine,threonine, tryptophan, valine, isoleucine and tyrosine, and wherein (a) and (b) are administered either simultaneously or in close temporal proximity.