Patent ID: 9687568
Date: 2017-06-27
CPC Classifications: A61K,A61P

Claim:
1. A method for near-infrared (NIR) fluorescence imaging of solid tumors in a patient during treatment with a first non-labeled monoclonal antibody, wherein the method comprises: a) administering to the patient a dose of the first non-labeled monoclonal antibody, wherein the first non-labeled monoclonal antibody specifically binds to a tumor antigen in the solid tumor; b) administering to the patient a dose of a second monoclonal antibody labeled with a NIR fluorescence label, wherein the second labeled monoclonal antibody also specifically binds to the tumor antigen, wherein the first and second monoclonal antibodies exhibit no cross reactivity; and c) measuring the NIR fluorescence signal of the second labeled monoclonal antibody in a region of the solid tumor.