Patent ID: 9532835
Date: 2017-01-03
CPC Classifications: A61B

Claim:
1. An in vivo method of treating a subject with a tumor comprising: (a) administering a composition comprising a molecular imaging probe to the subject, wherein the imaging probe is a clearance differential probe including a fluorescent label with optical properties in the visible spectrum of 350-670 nm attached to a pharmacokinetic modifier that results in the molecular imaging probe clearing preferentially from healthy tissue leaving tumor cells labeled; (b) permitting the molecular imaging probe to clear preferentially from healthy tissue leaving tumor cells labeled; (c) performing initial resection surgery to remove cancer cells from the subject thereby creating a resection bed; (d) treating the resection bed with light energy and obtaining an in situ image of the bed using an imaging system, wherein the image allows for the detection of the tumor cells, if present in the resection bed; and (e) if tumor cells are detected in (d), performing further resection surgery to remove labeled tumor cells.