Patent ID: 9645106
Date: 2017-05-09
CPC Classifications: G01N

Claim:
1. A monolithically integrated sensor assembly configured for detecting DNA single strands possibly contained in an analyte, comprising: a substrate; at least one sensor electrode arranged at least one of on and in the substrate, and coated with a sensor-active layer at which are generated electrochemically active catcher DNA single strands in the presence of the DNA single strands to be detected, the electrochemically active catcher DNA single strands being detectable by producing an electrical sensor signal based on DNA single strands detected by the at least one sensor electrode; a plurality of comparison electrodes, at which a plurality of electrical comparison signals independent of the electrical sensor signal is detected, wherein the plurality of comparison electrodes is configured for measuring the electrical comparison signal simultaneously with measurement of the electrical sensor signal detected by the at least one sensor electrode in the presence of the DNA single strands to be detected, and the electrical comparison signal is at least one selected from a background signal, a noise signal and a zero signal which do not originate from the sensor event; and an operating circuit integrated at least one of on and in the substrate, and configured for driving the at least one sensor electrode, the operating circuit including at least one evaluation unit, wherein said evaluation unit is configured to carry out a statistical averaging of the comparison signals detected from the plurality of comparison electrodes and to jointly evaluate the sensor signal and the statistical averaging of the comparison signals so as to eliminate undesirable disturbing contributions whereby detection sensitivity is increased, signal-to-noise ratio improved, and noise margin increased.