Patent ID: 9549996
Date: 2017-01-24
CPC Classifications: A61K

Claim:
1. A method of synthesizing a porous silica particle for medical imaging, comprising the steps of: incorporating a bridged silane fluorescent dye throughout a matrix of the porous silica particle via a copolymerization reaction between a bridged silane fluorescent dye and a tetralkoxysilane in the presence of a surfactant, wherein the bridged silane fluorescent dye has the general chemical structure (R′O)3Si—R—Si(OR′)3, wherein R is a fluorescent organic bridging group, and wherein R′ is a methyl or ethyl group; removing the surfactant from within pores of the porous silica particle; loading an additional functionality within the pores of the porous silica particle, wherein the additional functionality comprises at least one of an imaging material or a pharmaceutical drug; bonding a surface modifier onto a surface of the porous silica particle, wherein the surface modifier comprises poly(ethylene glycol); wherein the bridged silane fluorescent dye comprises 4,4′-bis(4-(triethoxysilyl)-styryl)biphenyl.