Patent ID: 9649319
Date: 2017-05-16
CPC Classifications: A61K,A61L

Claim:
1. A process for preparing a brinzolamide ophthalmic formulation, comprising: a) sterilizing brinzolamide by dry heat sterilization at a temperature of between 80° C. and 125° C.; b) mixing said brinzolamide with a sterile surfactant solution comprising a surfactant to obtain a slurry; c) optionally reducing the particle size of particles within said slurry until homogeneity is obtained; d) preparing a suspension vehicle comprising a solution of a polymer suitable for ophthalmic use, a tonicity agent, a preservative agent, and optionally a second drug; e) autoclaving said suspension vehicle; and f) mixing said slurry and said suspension vehicle to prepare a homogeneous ophthalmic suspension of brinzolamide.