Patent ID: 9682127
Date: 2017-06-20
CPC Classifications: A61K,A61P,C07K,Y10T

Claim:
1. A suspension formulation comprising: a particle formulation comprising: an insulinotropic peptide, an antioxidant, and a buffer, wherein the insulinotropic peptide is at least one of exenatide, a derivative of exenatide, and an analogue of exenatide; and a non-aqueous, single-phase suspension vehicle that comprises about 20 wt % to about 60 wt % solvent and about 80 wt % to about 40 wt % pyrrolidone polymer, the suspension vehicle having a viscosity from 5,000 poise to 50,000 poise at 33° C.; wherein: the solvent is at least one of lauryl lactate, lauryl alcohol, and benzyl benzoate; 30 to 90% by weight of the particle formulation is the insulinotropic peptide; the particle formulation has a wt % ratio of insulinotropic peptide to antioxidant of 2.5/1 to 10/1; and the particle formulation is dispersed in the suspension vehicle.