Patent ID: 9593380
Date: 2017-03-14
CPC Classifications: C07K,C12Q,G01N

Claim:
1. A method of and treating prostate cancer in a subject, the method comprising: (a) detecting an alteration in a HoxB13 nucleic acid sequence or amino acid sequence in a biological sample obtained from the subject, wherein the alteration in HOXB13 is selected from the group consisting of: a change of adenosine for guanine in the second position of codon 84 (GGA-GAA) resulting in a nonconservative substitution of glutamic acid for glycine (G84E); a missense mutation 685C-G resulting in the substitution of glycine for arginine at position 229 (R229G); a substitution mutation 431T-C resulting in a substitution of leucine for proline (L144P); and a substitution of aspartic acid for tyrosine (Y88D) at codon 88 (262T-G), and (b) administering a therapeutic regimen selected from the group consisting of radical prostatectomy, radiation therapy, hormone therapy and chemotherapy, for treating the subject.