Patent ID: 9593377
Date: 2017-03-14
CPC Classifications: C12Q,G16B

Claim:
1. A method comprising: a. assaying a biological sample from a subject to determine whether the subject has a tumor or is at risk of developing a tumor, by detecting expression of at least two determinants selected from a KRAS activation profile, wherein the determinants are ITGB2 and HEY1; b. comparing the expression of said determinants to the expression of said determinants in a reference sample known to be free of tumor(s); c. determining that the subject has a tumor or is at risk of developing a tumor if the determinants are upregulated in comparison to the reference sample; and d. administering a treatment regimen, comprising administration of a prophylactic or a therapeutic compound that targets the KRAS oncogene or RAS pathway if the subject is determined to have a tumor.