Patent ID: 9611222
Date: 2017-04-04
CPC Classifications: A61P,C07D

Claim:
1. A compound having Formula I: or a pharmaceutically acceptable salt, or solvate thereof, wherein: Z R a) hydrogen; b) halogen; c) hydroxy; d) cyano; e) optionally substituted alkyl; f) alkoxy; g) haloalkoxy; and h) haloalkyl; A X is —O—; A G is selected from the group consisting of: a) cyano; wherein: R a) hydrogen; b) optionally substituted alkyl; c) optionally substituted cycloalkyl; d) optionally substituted heterocyclo; e) optionally substituted aryl; f) optionally substituted heteroaryl; g) aralkyl; h) hydroxyalkyl; i) (cyano)alkyl; j) (heterocyclo)alkyl; k) (heteroaryl)alkyl; l) (amino)alkyl; m) (alkylamino)alkyl; n) (dialkylamino)alkyl, and o) —(CH R R a) hydrogen; b) optionally substituted alkyl; c) optionally substituted cycloalkyl; d) optionally substituted heterocyclo; e) optionally substituted aryl; f) optionally substituted heteroaryl; g) hydroxyalkyl h) (heterocyclo)alkyl; i) (heteroaryl)alkyl; j) (amino)alkyl; k) (alkylamino)alkyl; l) (dialkylamino)alkyl; m) (carboxamido)alkyl; n) (cyano)alkyl, and o) —(CH R R a) hydrogen; b) optionally substituted alkyl; c) optionally substituted cycloalkyl; d) optionally substituted heterocyclo; e) optionally substituted aryl; f) optionally substituted heteroaryl; g) (heterocyclo)alkyl; h) (heteroaryl)alkyl; i) (amino)alkyl; j) (alkylamino)alkyl; k) (dialkylamino)alkyl; and l) —(CH R a) hydrogen; b) optionally substituted alkyl; and c) —(CH L is selected from the group consisting of —O— and —NR R R R m, n, o, p, and q are each independently 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, or 11; w is 0, 1, 2, 3, 4 or 5; x and y are each independently 1, 2, 3, or 4; E is selected from the group consisting of: a) halogen; b) optionally substituted heteroaryl; c) optionally substituted heterocyclo; d) hydroxyalkyl; wherein: R a) hydrogen; b) optionally substituted alkyl; c) —SO d) —COR e) optionally substituted aryl; f) optionally substituted heteroaryl; g) (heterocyclo)alkyl; h) (heteroaryl)alkyl; i) (amino)alkyl; j) (alkylamino)alkyl; k) (dialkylamino)alkyl; l) (carboxamido)alkyl; m) (cyano)alkyl; and n) hydroxyalkyl; or R R a) hydrogen; b) optionally substituted alkyl; c) optionally substituted cycloalkyl; d) optionally substituted aryl; e) optionally substituted heteroaryl; f) (heterocyclo)alkyl; g) (heteroaryl)alkyl; and h) (dialkylamino)alkyl; or R R R R R a) hydrogen; b) optionally substituted alkyl; c) optionally substituted cycloalkyl; d) optionally substituted aryl; e) optionally substituted heteroaryl; f) (heterocyclo)alkyl; g) (heteroaryl)alkyl; and h) (dialkylamino)alkyl; or R R R R t and u are each independently 0, 1, 2, or 3; and v is 1, 2, or 3; wherein: 1) when G is: w is 0, and E is: then R 2) when G is: w is 0, and E is: then u is 1, 2, or 3; 3) when G is: and R 4) when G is: and w is 0, then E is not a morpholinyl group.