Patent ID: 9719993
Date: 2017-08-01
CPC Classifications: A61K,A61L,A61M,C07K,C12N,G01N

Claim:
1. A method for determining the presence or absence of an autoantibody in a sample obtained from a subject, wherein the autoantibody is capable of binding to a protein dipeptidyl-peptidase-like protein-6 (DPPX), comprising: a. contacting the sample with the protein DPPX, and b. determining the presence or absence of the autoantibody in the sample, wherein the protein DPPX comprises: (i) the sequence according to SEQ ID NO: 1, 2, 3, or 4, (ii) a polypeptide having the extracellular domain according to SEQ ID NO: 2 and the intracellular and transmembrane domains according to SEQ ID NO: 3 or 4, (iii) a sequence with at least 90% sequence identity to SEQ ID NO: 1, 2, 3, or 4, or (iv) a sequence with at least 90% sequence identity to the polypeptide having the extracellular domain according to SEQ ID NO: 2 and intracellular and transmembrane domains according to SEQ ID NO: 3 or 4.