Patent ID: 9689000
Date: 2017-06-27
CPC Classifications: A61K,A61P,C12N

Claim:
1. A gene expression regulatory sequence, comprising: (i) a hypoxia-response elements (HRE) enhancer sequence; (ii) an E2F promoter consisting of the nucleotide sequence as set forth in SEQ ID NO: 1, and (iii) a telomere reverse transcriptase (TERT) promoter consisting of the nucleotide sequence of as set forth in SEQ ID NO: 3; wherein the gene expression regulatory sequence comprises the HRE sequence, the E2F promoter and the TERT promoter sequence in a 5′ to 3′ direction, and the E2F promoter as set forth in (ii) is contiguously repeated 2 to 10 times, and the HRE enhancer sequence, the E2F promoter sequence and the TERT promoter sequence cooperatively trigger the expression of a gene.