Patent ID: 9556267
Date: 2017-01-31
CPC Classifications: A61K,A61P,C07K

Claim:
1. An isolated antibody that binds to low density lipoprotein receptor-related protein 6 (LRP6), wherein the antibody comprises a heavy chain variable domain (VH) comprising (a) hypervariable region (HVR)-H1 comprising the amino acid sequence of SEQ ID NO: 22; (b) HVR-H2 comprising the amino acid sequence of SEQ ID NO: 23; and (c) HVR-H3 comprising the amino acid sequence of SEQ ID NO: 24, and a light chain variable domain (VL) comprising (d) HVR-L1 comprising the amino acid sequence of SEQ ID NO: 25; (e) HVR-L2 comprising the amino acid sequence of SEQ ID NO: 26; and (f) HVR-L3 comprising the amino acid sequence of SEQ ID NO: 27.