Patent ID: 9572910
Date: 2017-02-21
CPC Classifications: A61K,A61L,C08F,C08G

Claim:
1. A biocompatible pH-responsive self-healing hydrogel comprising a cross-linked polymer comprising: (a) a plurality of macromonomers each comprising at least four terminal catechol moieties and having a molecular weight of 1,000 to 20,000 Daltons; and (b) one or more cross-linkers each comprising two or more terminal boronic acid moieties; wherein the catechol moieties of the macromonomers are covalently bonded to the boronic acid moieties of the cross linker to form a tetrahedral borate ester, wherein the macromonomers are cross-linked into the polymer when the macromonomers are at physiological pH or above and the polymer dissociates into the macromonmers at pH 3.0.