Patent ID: 9677055
Date: 2017-06-13
CPC Classifications: A61K,A61P,C07K,C12N,C12Y

Claim:
1. A polypeptide having at least one Pseudomonas exotoxin A (PE-A) biological activity, wherein said polypeptide comprises one or more amino acid substitutions compared to a wild-type PE-A polypeptide, wherein said one or more amino acid substitutions is a substitution of a different amino acid at one or more positions corresponding to amino acid residues in the polypeptide of SEQ ID NO:1, wherein one of said substitutions is selected from the group consisting of: a) glycine (G) at position 147 is substituted with an aliphatic amino acid residue; and, b) glycine (G) at position 147 is substituted with alanine (A), serine (S), or threonine (T).