Patent ID: 9733254
Date: 2017-08-15
CPC Classifications: G01N

Claim:
1. An in vitro method of determining a change in a property of a drug formulation that occurs on administration, the method employing an apparatus that comprises: a membrane cassette comprising a chamber having a membrane, the membrane having perforations through which components of the drug formulation are capable of diffusing for simulating changes that occur on administration of the drug formulation, wherein the chamber of the membrane cassette contains one or more components found in the site of administration for simulating conditions at the site; a bath that contains a liquid medium and said membrane cassette submerged therein; a probe capable of detecting a change in a property of the drug formulation inside the membrane cassette, and optionally a change in a property of the drug formulation in the bath, wherein the method comprises the steps of: (a) arranging the membrane cassette in the bath; (b) introducing the drug formulation into the chamber of the membrane cassette by injection; (c) optionally changing one or more components or conditions of the drug formulation or the liquid medium; and (d) determining the change of the property of the drug formulation using the probe.