Patent ID: 9731062
Date: 2017-08-15
CPC Classifications: A61M,B01D,G01N

Claim:
1. A blood cleansing device configured for microfluidic separation of undesirable particles from formed elements of whole blood, the blood cleansing device comprising: at least one separation channel configured to provide (a) a first portion where a first standing acoustic wave drives the formed elements of the whole blood and the captures particles along a first longitudinal axis parallel and against to a wall of the at least one separation channel and (b) a second portion where a second standing acoustic wave drives the formed elements of the whole blood toward a second longitudinal axis in an interior region of the second portion and parallel to the wall of the at least one separation channel, the at least one separation channel further comprising: a first inlet configured to introduce the whole blood and the plurality of capture particles into the first portion of the at least one separation channel, the whole blood including plasma, the plurality of formed elements having a first positive contrast factor and the plurality of undesirable particles having a second positive contrast factor less than the first positive contrast factor; a first outlet positioned within the separation channel downstream from the first inlet; a second outlet for the removal of the plurality of capture particles bound to at least a portion of the plurality of undesirable particles, the second outlet positioned against the wall of the at least one separation channel and downstream of the first inlet; a second inlet positioned within the separation channel downstream of the first outlet and upstream of the second outlet; and a third outlet for the removal of the plurality of formed elements, the third outlet positioned parallel with the second longitudinal axis in the interior region of the second portion and parallel to the wall of the at least one separation channel in the second portion of the at least one separation channel and positioned away from the wall of the at least one separation channel a first distance proportional to a distance from the second standing acoustic wave, a flow rate of the whole blood, and the first negative contrast factor, wherein the at least one separation channel is configured to separate the plurality of undesirable particles from the formed elements by: (i) aggregating the plurality of undesirable particles bound to the plurality of capture particles at a first pressure node in the first portion of the at least one separation channel and aligned with the first longitudinal axis parallel and against to a wall of the at least one separation channel; (ii) driving the formed elements of the whole blood toward a second pressure node in the second portion of the at least one separation channel and aligned with the second longitudinal axis in the interior region of the second portion and parallel to the wall of the at least one separation channel, wherein the formed elements are driven at least the first distance away from the wall and into the third outlet; and (iii) driving the plurality of capture particles bound to the plurality of undesirable particles toward the second pressure node in the second portion of the at least one separation channel aligned with the second longitudinal axis a second distance less than the first distance.