Patent ID: 9642872
Date: 2017-05-09
CPC Classifications: A61K,A61P,C12N

Claim:
1. A method of treating a B-cell lymphoma characterized by over-expression of Myc, comprising administering to an individual in need thereof a therapeutically effective amount of a composition comprising: (a) a synthetic oligonucleotide duplex comprising a first oligonucleotide strand consisting of a miR-34 sequence selected from the group consisting of: microRNA-34a (SEQ ID NO: 1), microRNA-34b (SEQ ID NO: 2), microRNA-34c-5p (SEQ ID NO: 3), and microRNA-34c-3p (SEQ ID NO: 4), and a second oligonucleotide strand comprising a sequence that is complementary to the first strand; and (b) a pharmaceutically acceptable carrier.