Patent ID: 9611317
Date: 2017-04-04
CPC Classifications: A61K,A61P,C07K,C12N

Claim:
1. A binding molecule genetically engineered to specifically recognize and bind to an epitope in influenza hemagglutinin protein (HA), having neutralizing activity against influenza viruses comprising HA of the H3 subtype and having cross-neutralizing activity against at least an influenza virus comprising HA of the H7 subtype, and/or an influenza virus comprising HA of the H10 subtype, wherein the binding molecule is selected from the group consisting of: a) a binding molecule comprising a heavy chain CDR1 region of SEQ ID NO:81, a heavy chain CDR2 region of SEQ ID NO:82, a heavy chain CDR3 region of SEQ ID NO:83, a light chain CDR1 region of SEQ ID NO:84, a light chain CDR2 region of SEQ ID NO:85, and a light chain CDR3 region of SEQ ID NO:86, b) a binding molecule comprising a heavy chain CDR1 region of SEQ ID NO:87, a heavy chain CDR2 region of SEQ ID NO:88, a heavy chain CDR3 region of SEQ ID NO:89, a light chain CDR1 region of SEQ ID NO:90, a light chain CDR2 region of SEQ ID NO:91, and a light chain CDR3 region of SEQ ID NO:92, c) a binding molecule comprising a heavy chain CDR1 region of SEQ ID NO:103, a heavy chain CDR2 region of SEQ ID NO:104, a heavy chain CDR3 region of SEQ ID NO:105, a light chain CDR1 region of SEQ ID NO:106, a light chain CDR2 region of SEQ ID NO:107, and a light chain CDR3 region of SEQ ID NO:108, d) a binding molecule comprising a heavy chain CDR1 region of SEQ ID NO:109, a heavy chain CDR2 region of SEQ ID NO:110, a heavy chain CDR3 region of SEQ ID NO:111, a light chain CDR1 region of SEQ ID NO:112, a light chain CDR2 region of SEQ ID NO:113, and a light chain CDR3 region of SEQ ID NO:114, e) a binding molecule comprising a heavy chain CDR1 region of SEQ ID NO:115, a heavy chain CDR2 region of SEQ ID NO:116, a heavy chain CDR3 region of SEQ ID NO:117, a light chain CDR1 region of SEQ ID NO:118, a light chain CDR2 region of SEQ ID NO:119, and a light chain CDR3 region of SEQ ID NO:120, f) a binding molecule comprising a heavy chain CDR1 region of SEQ ID NO:121, a heavy chain CDR2 region of SEQ ID NO:122, a heavy chain CDR3 region of SEQ ID NO:123, a light chain CDR1 region of SEQ ID NO:124, a light chain CDR2 region of SEQ ID NO:125, and a light chain CDR3 region of SEQ ID NO:126, g) a binding molecule comprising a heavy chain CDR1 region of SEQ ID NO:126, a heavy chain CDR2 region of SEQ ID NO:127, a heavy chain CDR3 region of SEQ ID NO:128, a light chain CDR1 region of SEQ ID NO:129, a light chain CDR2 region of SEQ ID NO:130, and a light chain CDR3 region of SEQ ID NO:131, h) a binding molecule comprising a heavy chain CDR1 region of SEQ ID NO:132, a heavy chain CDR2 region of SEQ ID NO:133, a heavy chain CDR3 region of SEQ ID NO:134, a light chain CDR1 region of SEQ ID NO:135, a light chain CDR2 region of SEQ ID NO:136, and a light chain CDR3 region of SEQ ID NO:137, i) a binding molecule comprising a heavy chain CDR1 region of SEQ ID NO:138, a heavy chain CDR2 region of SEQ ID NO:139, a heavy chain CDR3 region of SEQ ID NO:140, a light chain CDR1 region of SEQ ID NO:141, a light chain CDR2 region of SEQ ID NO:142, and a light chain CDR3 region of SEQ ID NO:143, and j) a binding molecule comprising a heavy chain CDR1 region of SEQ ID NO:144, a heavy chain CDR2 region of SEQ ID NO:145, a heavy chain CDR3 region of SEQ ID NO:146, a light chain CDR1 region of SEQ ID NO:147, a light chain CDR2 region of SEQ ID NO:148, and a light chain CDR3 region of SEQ ID NO:149, k) a binding molecule comprising a heavy chain CDR1 region of SEQ ID NO:150, a heavy chain CDR2 region of SEQ ID NO:151, a heavy chain CDR3 region of SEQ ID NO:152, a light chain CDR1 region of SEQ ID NO:153, a light chain CDR2 region of SEQ ID NO:154, and a light chain CDR3 region of SEQ ID NO:155, l) a binding molecule comprising a heavy chain CDR1 region of SEQ ID NO:156, a heavy chain CDR2 region of SEQ ID NO:157, a heavy chain CDR3 region of SEQ ID NO:158, a light chain CDR1 region of SEQ ID NO:159, a light chain CDR2 region of SEQ ID NO:160, and a light chain CDR3 region of SEQ ID NO:161, m) a binding molecule comprising a heavy chain CDR1 region of SEQ ID NO:162, a heavy chain CDR2 region of SEQ ID NO:163, a heavy chain CDR3 region of SEQ ID NO:164, a light chain CDR1 region of SEQ ID NO:165, a light chain CDR2 region of SEQ ID NO:166, and a light chain CDR3 region of SEQ ID NO:167, n) a binding molecule comprising a heavy chain CDR1 region of SEQ ID NO:168, a heavy chain CDR2 region of SEQ ID NO:169, a heavy chain CDR3 region of SEQ ID NO:170, a light chain CDR1 region of SEQ ID NO:171, a light chain CDR2 region of SEQ ID NO:172, and a light chain CDR3 region of SEQ ID NO:173, o) a binding molecule comprising a heavy chain CDR1 region of SEQ ID NO:173, a heavy chain CDR2 region of SEQ ID NO:174, a heavy chain CDR3 region of SEQ ID NO:175, a light chain CDR1 region of SEQ ID NO:176, a light chain CDR2 region of SEQ ID NO:177, and a light chain CDR3 region of SEQ ID NO:178, and p) a binding molecule comprising a heavy chain CDR1 region of SEQ ID NO:179, a heavy chain CDR2 region of SEQ ID NO:180, a heavy chain CDR3 region of SEQ ID NO:181, a light chain CDR1 region of SEQ ID NO:182, a light chain CDR2 region of SEQ ID NO:183, and a light chain CDR3 region of SEQ ID NO:184.