Patent ID: 9603861
Date: 2017-03-28
CPC Classifications: A61K,A61P

Claim:
1. A method of treating a hyperproliferative skin disease or disorder in a subject in need thereof, the method comprising topically administering to the subject a therapeutically effective amount of a pharmaceutical composition, the composition comprising: calcipotriol at a concentration of about 20 μg/g to about 70 μg/g; nicotinamide at a concentration of about 1 to about 20 mg/g; and a polyethylene glycol-based dermatologically acceptable carrier comprising a mixture of PEG-4000, PEG-400 and polyoxyethylated stearyl alcohol (Steareth-20), wherein the PEG-400 comprises about 70% to about 80% (w/w) of the composition and the PEG-4000 comprises about 15% to about 25% (w/w) of the composition; thereby treating a hyperproliferative skin disease or disorder in the subject, wherein the hyperproliferative disease or disorder is selected from the group consisting of: psoriasis, solar keratosis, ichthyosis, Grover's disease, common warts, keratoacanthoma, seborrhoeic keratosis, scleroderma, and seborrhea.