Patent ID: 9567387
Date: 2017-02-14
CPC Classifications: A61K,A61P,C07K,C12Q,G01N

Claim:
1. A method of detecting the presence of a target renal cell carcinoma (RCC) cell in a host, comprising: (i) contacting a sample comprising cells of the host with a TCR expressed on the surface of a T cell, wherein the TCR comprises (a) SEQ ID NOs: 3 and 4 or (b) SEQ ID NO: 4 and either SEQ ID NO: 22 or 23, thereby specifically binding the TCR to the target RCC cell, and (ii) detecting the specific binding of the TCR to the target RCC cell, wherein detection of the specific binding of the TCR to the target RCC cell is indicative of the presence of the target RCC cell in the host, wherein the target RCC cell expresses CD58 and TRAIL-R1, and wherein soluble TRAIL is presented by the TRAIL-R1.