Patent ID: 9555003
Date: 2017-01-31
CPC Classifications: A61K,A61P

Claim:
1. A compound oral core-coated solid formulation, in the form of a coated tablet with coated core, comprising rifampicin, isoniazid, pyrazinamide and ethambutol hydrochloride as active ingredients, in which the inner core comprises isoniazid or rifampicin, and is coated with a non-pH dependent water soluble isolating film, and the rifampicin is in the form of solid dispersion in which the rifampicin is dispersed in an enteric solid carrier, and the weight ratio range of the rifampicin to the enteric solid carrier is from 2:1 to 1:3, and said enteric solid carrier is hydroxypropyl methyl cellulose acetate succinate (HPMCAS); and the outer layer of the core-coated solid formulation is coated with a non-pH dependent water soluble coating film which serves as a barrier to both moisture and light.