Patent ID: 9733260
Date: 2017-08-15
CPC Classifications: C07K,C12Q,G01N

Claim:
1. A method of detecting fragments of Tau protein formed by secretase cleavage of Tau protein in a human patient, said method comprising: a. obtaining a sample from the human patient; and b. detecting whether said fragments of Tau are present in the sample by contacting the sample with an antibody and detecting binding between the fragments and the antibody wherein said antibody is raised against a synthetic peptide corresponding to a C-terminal or N-terminal neo-epitope amino acid sequence formed by cleavage of Tau protein by a secretase and has specific binding affinity for said C-terminal or N-terminal neo-epitope amino acid sequence, and wherein said antibody has specific binding affinity for any of the following sequences at the N terminal of a peptide: where M indicates an oxidised methionine or wherein said antibody has specific binding affinity for any of the following sequences at the C terminal of a peptide: where M indicates an oxidised methionine.