Patent ID: 9657279
Date: 2017-05-23
CPC Classifications: C12N,C12P,Y02E

Claim:
1. A co-culture system comprising a culture medium and (i) a cellulosic bacterium component, wherein the bacteria metabolize cellulose and produce one or more metabolic products, (ii) a cellulosic material or cellulose source, and (iii) a yeast component, wherein the yeast uses at least one metabolic product of the bacteria as a carbon source and produces a product different from the one or more metabolic products in (i), wherein the at least one metabolic product is selected from the group consisting of ethanol, acetate, lactate, succinate, citrate, formate, and malate, wherein growth of the bacteria is inhibited by the at least one metabolic product, wherein the bacteria and yeast have a symbiotic relationship in culture and grow together while maintaining a relatively constant ratio of species populations such that neither microorganism overtakes the other, wherein the yeast is recombinantly modified to express a heterologous protein or over-express an endogenous protein or is a recombinantly modified to knock out expression of an endogenous protein, and wherein the yeast is