Patent ID: 9668978
Date: 2017-06-06
CPC Classifications: A61K,A61P

Claim:
1. Method for producing enteric calcium alginate microcapsules with a homogeneous composition containing diclofenac or one of the salts thereof, said method comprising the following steps: A) preparing a solution of an alginate salt, selected from sodium, potassium or ammonium alginate, in water-ethanol and dissolving under stirring in an active ingredient comprising diclofenac or one of the salts thereof in the presence of a surfactant selected from the group consisting of: sorbitan monostearate, sorbitan monooleate, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan monooleate, and polyoxyethylene sorbitan monolaurate, and sodium bicarbonate, at a temperature under 60° C.; B) adding the solution obtained in A) to a solution of calcium chloride, while controlling the temperature under 60° C., throughout the process so as to form microcapsules; C) resuspending the microcapsules formed and isolated without previous drying in a solution of said alginate salt, at a concentration of between 0.05% and 0.1%, under stirring for 30 to 120 minutes at ambient temperature; D) separating by filtering, drying and sieving successively through 1000 and 250 micron meshes, selecting for producing the pharmaceutical composition only the fraction of microcapsules obtained and sized between both meshes, wherein the microcapsules obtained and selected have an active ingredient content higher than 55%; E) and optionally, converting the microcapsules thus obtained into prolonged release microcapsules.