Patent ID: 9669102
Date: 2017-06-06
CPC Classifications: A61K,A61P,C07D,C07K

Claim:
1. A compound represented by any one of the following formulas: or a pharmaceutically acceptable salt thereof, wherein: one of L′, L″, and L′″ is represented by the following formula: and the other two are the same or different, and are independently selected from —H, an optionally substituted linear, branched or cyclic alkyl, alkenyl or alkynyl having from 1 to 10 carbon atoms, —(CH 2 CH 2 O) n —R c , halogen, —NH(C═NH)NH 2 , —OR, —NR′R″, —NO 2 , —NR′COR″, —SR, —SOR′, —SO 2 R′, —SO 3 H, —OSO 3 H, —SO 2 NR′R″, cyano, an azido, —COR′, —OCOR′, and —OCONR′R″; one of the Z P is an amino acid residue or a peptide containing between 2 to 20 amino acid residues; R J is —COOH or —COE, wherein —COE represents a reactive ester and R the double line Y is a leaving group selected from —OR, —OCOR′, —OCOOR′, —OCONR′R″, —NR′R″, —NR′COR″, —NR′NR′R″, an optionally substituted 5- or 6-membered nitrogen-containing monocyclic heterocycle —NR′(C═NH)NR′R″, an amino acid, or a peptide represented by —NRCOP′, —SR, —SOR′, halogen, cyano, azido, —OSO P′ is an amino acid residue or a polypeptide containing between 2 to 20 amino acid residues, R, for each occurrence, is independently selected from the group consisting of —H, an optionally substituted linear, branched or cyclic alkyl, alkenyl or alkynyl having from 1 to 10 carbon atoms, —(CH R′ and R″ are each independently selected from —H, —OH, —OR, —NHR, —NR R n is an integer from 1 to 24; X′ is selected from —H, an amine-protecting group, an optionally substituted linear, branched or cyclic alkyl, alkenyl or alkynyl having from 1 to 10 carbon atoms, —(CH Y′ is selected from —H, an oxo group, an optionally substituted linear, branched or cyclic alkyl, alkenyl or alkynyl having from 1 to 10 carbon atoms, an optionally substituted 6- to 18-membered aryl, an optionally substituted 5- to 18-membered heteroaryl ring containing one or more heteroatoms independently selected from nitrogen, oxygen, and sulfur, an optionally substituted 3- to 18-membered heterocyclic ring having 1 to 6 heteroatoms; R R G is —CH— or —N—; A and A′ are the same or different, and are independently selected from —O—, C(═O)—, —CRR′O—, —CRR′—, —S—, —CRR'S—, —NR R wherein the optional substituent described above is a linear, branched or cyclic alkyl, alkenyl or alkynyl having from 1 to 10 carbon bon atoms, aryl, heteroaryl, heterocyclyl, halogen, —NH(C═NH)NH