Patent ID: 9617540
Date: 2017-04-11
CPC Classifications: A61P,C12N,C12Y

Claim:
1. A compound comprising a short antisense oligonucleotide consisting of 12 to 14 linked nucleosides and having: a gap region consisting of 8 to 12 linked 2′-deoxynucleosides; a 5′-wing region adjacent to the gap region at the 5′side of the gap region and consisting of 1 or 2 linked modified nucleosides; and a 3′-wing region adjacent to the gap region at the 3′ side of the gap region and consisting of 1 or 2 linked modified nucleosides; wherein at least one modified nucleoside of one or both of the 5′-wing region and the 3′-wing region is a high-affinity modified monomer.