Patent ID: 9677126
Date: 2017-06-13
CPC Classifications: C12Q,G01N

Claim:
1. A method of detecting a plurality of target polynucleotides, the method comprising: a) contacting a population of coded molecules with a plurality of target polynucleotides, wherein the population of coded molecules comprises a plurality of subpopulations and each coded molecule of each subpopulation comprises: b) modifying coded molecules of the population of coded molecules by modifying the target probe with a modifying agent following hybridizing the target probe with the different target polynucleotide, wherein the modified target probe is indicative of the different target polynucleotide; c) translocating the modified coded molecules through a nanopore and detecting the signal pattern; and d) associating the detected signal pattern to a specific subpopulation of coded molecules in the plurality of subpopulations, wherein a difference in the detected signal pattern compared to the signal pattern of the specific subpopulation indicates the presence of the different target polynucleotide.