Patent ID: 9688747
Date: 2017-06-27
CPC Classifications: A61P,C07K

Claim:
1. An isolated conformation-specific antibody or antibody fragment thereof, wherein said antibody or antibody fragment comprises: (a) a heavy chain variable region comprising the heavy chain CDRs of SEQ ID NOs:1-3, and a light chain variable region comprising the light chain CDRs of SEQ ID NOs:4-6; or (b) a heavy chain variable region comprising the heavy chain CDRs of SEQ ID NOs:7-9, and a light chain variable region comprising the light chain CDRs of SEQ ID NOs:10-12; and wherein said isolated antibody or antibody fragment thereof binds specifically to the cis conformation of phosphorylated-Threonine231-tau protein (pT231-tau).