Patent ID: 9546177
Date: 2017-01-17
CPC Classifications: C07D

Claim:
1. A process for producing noroxymorphone from morphine, comprising reacting morphine of formula (II) to a compound of formula (IIIa) or (IIIb), wherein R R reacting the compound of formula (IIIa) or (IIIb) to a compound of formula (IVa) or (IVb), respectively, wherein R wherein the reaction of the compound of formula (IIIa) or (IIIb) to a compound of formula (IVa) or (IVb), is conducted by a Swern oxidation with pre-cooling; reacting the compound of formula (IVa) or (IVb) to a compound of formula (Va) or (Vb), respectively, wherein R R R reacting the compound of formula (Va) or (Vb) to a compound of formula (VIa) or (VIb), respectively, wherein R wherein the reaction of the compound of formula (Va) or (Vb) to the compound of formula (VIa) or (VIb) is carried out with hydrogen peroxide and an organic acid, wherein the organic acid and the hydrogen peroxide are mixed and allowed to react for an induction time prior to addition to the compound of formula (Va) or (Vb); reacting the compound of formula (VIa) or (VIb) to a compound of formula (VIIa) or (VIIb), respectively, wherein R reacting the compound of formula (VIIa) or (VIIb) to noroxymorphone of formula (I),