Patent ID: 9592206
Date: 2017-03-14
CPC Classifications: A61B,A61F,A61K,A61L,A61P

Claim:
1. A method for controlling the generation of biologically desirable voids in an allograft placed in proximity to tissue in a patient and for controlling at least one elution profile of a bioactive agent, comprising: selecting at least one water-soluble inorganic bioactive material having at least one bioactive agent, the bioactive material having at least a first average particle dimension, at least a first dissolution rate, and being capable of controlling an elution profile for the bioactive agent during dissolution of the bioactive material over at least a selected period; selecting an allograft having a porous structure matrix that defines interstices within the porous structure, the interstices having an average dimension, wherein the first average particle dimension is selected to be smaller than the average dimension of the interstices; blending the water-soluble inorganic bioactive material, in a quantity capable of providing a therapeutically effective concentration of the bioactive agent, within at least some of the interstices of the porous structure; attaching the water-soluble inorganic bioactive material within the interstices, utilizing at least one biocompatible binder to attach the inorganic bioactive material within the interstices; and placing the allograft carrying the inorganic bioactive material and the biocompatible binder into the patient in proximity to tissue so that the water-soluble inorganic bioactive material progressively dissolves at a predetermined rate to generate the selected elution profile for the bioactive agent to provide a therapeutically effective concentration of the bioactive agent over at least the selected period while generating biologically desirable voids by gradually exposing more of the interstices into which tissue can then grow to assist fixation of the allograft within the patient.