Patent ID: 9683019
Date: 2017-06-20
CPC Classifications: A61K,A61P,C07K

Claim:
1. A method of slowing or arresting the development of acute decompensated heart failure, chronic heart failure, pulmonary hypertension, atherosclerosis or hypertension, in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a cyclic polypeptide having the following formula I (SEQ ID NO: 1): wherein: X1 is the N-terminus of the polypeptide and is either absent, Q, A or pE or X1 is selected from C, c, hC, D-hC; wherein the side chain of C, c, hC or D-hC forms a disulfide bond with the side chain of X7; X3 is P or X3 is selected from C, c, hC and D-hC; wherein the side chain of C, c, hC or D-hC forms a disulfide bond with the side chain of X7; X4 is R or X4 is selected from C, c, hC and D-hC; wherein the side chain of C, c, hC or D-hC forms a disulfide bond with the side chain of X7; wherein only one of X1, X3 and X4 is a sulfur contain amino-acid selected from C, c, hC and D-hC; X7 is C, c, hC or D-hC; and the side chain of X7 forms a disulfide bond with the side chain of C, c, hC or D-hC of either X1, X3 or X4; X8 is K or F; X9 is G, A, a or absent; X10 is P or absent; X11 is D-Nle, Nle, M or f; and X12 is absent or P, f, a, D-Nva or D-Abu; X13 is the C-terminus and is absent or is selected from (N-Me)F, F, f, a, y and Nal; wherein: Nle is L-norleucine; D-Nle is D-norleucine; D-hC is D-homocysteine hC is L-homocysteine; Nal is L-naphathaline; D-Nva is D-norvaline; D-Abu is D-2-aminobutyric acid; pE is L-pyroglutamic acid; or an amide, an ester or a salt of the polypeptide.