Patent ID: 9687556
Date: 2017-06-27
CPC Classifications: A61K,A61P,C07J,C12N,C12Y

Claim:
1. A method for delivery of a drug across biological membranes, the method comprising utilization of a Conjugate, having the structure as set forth in Formula I: wherein: D is a drug, selected from the group consisting of a small-molecule drug, a peptide, a protein; a single-stranded or a double-stranded DNA or RNA; siRNA and ASO; y, z and w are each an integer, independently selected from 0, 1, 2, 3, 4, 5, 6, wherein at least one of y, z or w is different from 0; E, E′ or E″ are the same or different, and are described by the general Formula (II): wherein A is selected from the structures as set forth in Formulae (III), (IV), (V) and (VI): M is selected from —O— or —CH B is a steroid moiety selected from the group consisting of cholesterol, bile acid, estradiol, estriol, or estrogen; wherein the steroid moiety is optionally further substituted by one or more groups selected from: Q is selected from null, ester, thio-ester, amide, carbamate, disulfide, ether, and triazole; L