Patent ID: 9683002
Date: 2017-06-20
CPC Classifications: A61K,A61P,C07D,C07F

Claim:
1. A compound of: (a) (R)-3-{N-(5′-chloro-2′-fluorobiphenyl-4-ylmethyl)-N′-[1-(3-chlorophenyl)-5-oxo-4,5-dihydro-1H-[1,2,4]triazole-3-carbonyl]hydrazino}-2-hydroxypropionic acid ethyl ester; (b) (R)-3-{N-(5′-chloro-2′-fluorobiphenyl-4-ylmethyl)-N′-[1-(3-chlorophenyl)-5-oxo-4,5-dihydro-1H-[1,2,4]triazole-3-carbonyl]hydrazino}-2-hydroxypropionic acid isobutyl ester; (c) (S)-2-amino-3-methylbutyric Acid (R)-3-{N-(5′-Chloro-2′-fluorobiphenyl-4-ylmethyl)-N′-[1-(3-chlorophenyl)-5-hydroxy-1H-[1,2,4]triazole-3-carbonyl]hydrazino}-2-hydroxypropionyloxymethyl ester; (d) (R)-3-{N-(5′-chloro-2′-fluorobiphenyl-4-ylmethyl)-N′-[1-(3-chlorophenyl)-5-hydroxy-1H-[1,2,4]triazole-3-carbonyl]hydrazino}-2-hydroxypropionic acid acetoxymethyl ester; (e) (S)-2-amino-3-methylbutyric Acid 5-[N′—((R)-2-Carboxy-2-hydroxyethyl)-N′-(5′-chloro-2′-fluorobiphenyl-4-ylmethyl)hydrazinocarbonyl]-2-(3-chlorophenyl)-2H-[1,2,4]triazol-3-yloxymethyl ester; (f) (R)-3-[N′-[5-acetoxymethoxy-1-(3-chlorophenyl)-1H-[1,2,4]triazole-3-carbonyl]-N-(5′-chloro-2′-fluorobiphenyl-4-ylmethyl)hydrazino]-2-hydroxypropionic acid; or