Patent ID: 9540629
Date: 2017-01-10
CPC Classifications: A61K,A61P,C07K,C12N,C12Y,G01N

Claim:
1. An isolated polynucleotide that encodes an aminoacyl-tRNA synthetase (AARS) polypeptide consisting of a sequence that is at least 95% identical over the entire length of SEQ ID NO: 12, 18, or 36 or a fragment thereof which is 90 or more contiguous amino acids of SEQ ID NO: 12, 18, or 36 wherein the polynucleotide is selected from (a) a cDNA polynucleotide and (b) a modified mRNA polynucleotide and wherein the encoded AARS polypeptide has an extracellular signaling activity.