Patent ID: 9561187
Date: 2017-02-07
CPC Classifications: A61K

Claim:
1. An extended-release drug composition comprising a monolithic matrix tablet comprising metoprolol containing granules and extragranular excipients wherein the granules comprise about: a. 20-30% of a metoprolol selected from the group consisting of metoprolol succinate and metoprolol tartrate; b. 5-10% dibasic calcium phosphate; c. 5-10% lactose monohydrate; d. 5-10% pregelatinized starch acetate; and e. 1-5% hydroxyl ethyl cellulose; and where the extragranular excipients comprise about: a. 5-15% carbomer homopolymer; b. 5-15% polyethylene oxide; c. 10-20% hypromellose; and d. 5-10% methacrylic acid copolymer.