Patent ID: 9540634
Date: 2017-01-10
CPC Classifications: C12N,C12Q

Claim:
1. A hybrid nucleic acid-peptide molecule comprising: a) a first, second, and third oligomer, wherein the first oligomer is linked to the second oligomer through a first photocleavable linker and the second oligomer is linked to the third oligomer through a second photocleavable linker, wherein the first, second, and third oligomers are arranged in a caged hairpin conformation wherein the second oligomer comprises a poly-A nucleic acid sequence, comprising at least 7 consecutive adenosines, that is complementary to a first nucleic acid sequence of the first oligomer, such that the first oligomer is hybridized to the second oligomer, and wherein the third oligomer comprises a poly-A nucleic acid sequence, comprising at least 7 consecutive adenosines, that is complementary to a second nucleic acid sequence of the first oligomer, such that the first oligomer is hybridized to the third oligomer; b) a label for isolating nucleic acids, wherein the label is linked to the first oligomer; c) a peptide moiety comprising a cell penetrating peptide (CPP).