Patent ID: 9592398
Date: 2017-03-14
CPC Classifications: A61B,A61M,A61N

Claim:
1. A leadless implantable medical device (IMD) comprising: a housing defining an outer surface and comprising an outlet; a pump reservoir positioned within the housing, wherein the pump reservoir is configured to store genetic material, wherein the genetic material is configured to generate at least one of a reduced stimulation threshold or new intrinsic biological pacemaker activity at a target cardiac tissue site of a patient adjacent to the outer surface of the housing, and wherein the genetic material is configured to generate the at least one of the reduced stimulation threshold or the new intrinsic biological pacemaker activity by at least inducing transgene expression to generate biological pacemaker cells in the cardiac tissue of the patient, wherein the biological pacemaker cells are capable of inducing a normal cardiac rhythm autonomously; a pump positioned within the housing, wherein the pump is configured to deliver the genetic material to the target cardiac tissue site via the outlet; a stimulation energy delivery element positioned on or within the housing; and a stimulation module within the housing and coupled to the stimulation energy delivery element, wherein the stimulation module is configured to deliver cardiac pacing to the target cardiac tissue site via the stimulation energy delivery element, the stimulation module comprising a control module configured to detect the at least one of the reduced stimulation threshold or the new intrinsic biological pacemaker activity in response to the delivery of the genetic material to the target cardiac tissue site via the pump and modify at least one parameter defining the stimulation in response to the detection of the at least one of the reduced stimulation threshold or the new intrinsic biological pacemaker activity at the target cardiac tissue site.