Patent ID: 9623156
Date: 2017-04-18
CPC Classifications: A61L

Claim:
1. A method of preparing a nitrogen-monoxide-containing coating film on a surface of a material comprising: (a) immersing a material whose surface is to be coated in a basic solution at pH 8.5 to pH 11, wherein said basic solution is at least one solution selected from the group consisting of a physiological saline solution, water, and tetrahydrofuran (THF); (b) adding a catecholamine to the basic solution used in operation (a) and keeping the material in the resulting mixture to form a catecholamine polymer coating film; (c) drying the material after the keeping of the material in operation (b); (d) introducing the material dried in operation (c) into a reactor containing another basic solution which contains one or more of sodium methoxide (NaOMe), methanol (MeOH), tetrahydrofuran (THF), or sodium hydroxide (NaOH); (e) purging the reactor used in operation (d) with argon (Ar) gas; and (f) introducing nitrogen monoxide into the reactor used in operation (e) to synthesize a diazeniumdiolate on a surface of the catecholamine polymer coating film.