Patent ID: 9609861
Date: 2017-04-04
CPC Classifications: A01N,A61J

Claim:
1. A method of storing platelets having a platelet surface, wherein sialic acid loss and galactose loss are reduced on the platelet surface of isolated platelets during storage, wherein the isolated platelets are obtained from one or more donors, the method comprises: a. contacting the isolated platelets with a Platelet Additive Solution (PAS) that comprises: to thereby obtain a platelet composition, wherein cleavage by the endogenous sialidase and β-galactosidase of sialic acid or galactose, respectively, is reduced, as compared to isolated platelets not subjected to Step a); and wherein once the platelet composition is transfused into a recipient, circulation time of platelets is increased by at least 10% and platelet clearance of the platelets is reduced, as compared to circulation time and platelet clearance of platelets that have not been subjected to Step a).