Patent ID: 9701740
Date: 2017-07-11
CPC Classifications: A61K,A61P,C07K

Claim:
1. A method of inhibiting DNA repair in neoplastic or virally transforming or virally transformed cells in a subject, comprising administering to the neoplastic, virally transforming or virally transformed cells in the subject a pharmaceutical composition comprising an effective amount of anti-DNA unconjugated antibodies or antigen binding fragments thereof to impair a DNA repair pathway, wherein all of the anti-DNA unconjugated antibodies or antigen binding fragments thereof of the pharmaceutical composition consist of one or more cell penetrating unconjugated monospecific anti-DNA antibodies or cell penetrating unconjugated antigen binding fragments thereof, wherein the cell penetrating unconjugated monospecific anti-DNA antibodies or cell penetrating unconjugated antigen binding fragments thereof consist of monoclonal antibody 3E10 produced by ATCC Accession No. PTA 2439 hybridoma, or a cell penetrating antigen binding fragment or humanized form thereof.