Patent ID: 9629798
Date: 2017-04-25
CPC Classifications: A61K,A61P,C12Y,Y10T

Claim:
1. A hemostatic composition comprising a plurality of porous gelatin microspheres, thrombin, a wetting agent, and a suspending agent; wherein the wetting agent and the suspending agent are present in a ratio of microspheres:the wetting agent and the suspending agent of 3:1 to 60:1 (w/w); wherein the gelatin is cross-linked gelatin; wherein the porous gelatin microspheres have a diameter from about 50 μm to about 500 μm, inclusive, when fully hydrated; wherein the porous gelatin microspheres contain pores having a pore diameter from about 15 μm to about 25 μm, inclusive; wherein the thrombin concentration is in a range of about 1,000 IU to about 2,000 IU per mL of rehydrated microsphere gel and a high level of thrombin is released from the hemostatic composition to yield a homogenous clot; wherein the hemostatic composition, when fully hydrated, remains flowable for at least 90 minutes, and wherein the wetting agent is poloxamer 188 and the suspending agent is carboxymethylcellulose.