Patent ID: 9611315
Date: 2017-04-04
CPC Classifications: A61P,C07K,G01N

Claim:
1. A monoclonal antibody that is non-human and that binds to a sub-sequence of a common sequence of an early gene protein from at least two oncogenic human papillomavirus (HPV) strains selected from the group consisting of HPV strains 16, 18, 31, 33, 52, and 58, wherein the common sequence is an amino acid sequence motif that is conserved within a same gene protein from the at least two oncogenic HPV strains, wherein the common sequence comprises at least 9 contiguous amino acids within a region of sequence similarity between the same early gene protein of the at least two oncogenic HPV strains, wherein the region of sequence similarity is located within amino acids 1-43 of the N-terminus of the same early gene protein or within 41 amino acids of the C-terminus of the same early gene protein, and wherein: a) the early gene protein from the at least two oncogenic HPV strains is encoded by a nucleic acid sequence within the HPV early gene protein 6-HPV early gene protein 7 (E6-E7) region of an HPV genome; and b) a dissociation constant of the monoclonal antibody for the early gene protein from the at least two oncogenic HPV strains is less than 10