Patent ID: 9605025
Date: 2017-03-28
CPC Classifications: A61K,A61P,C07K

Claim:
1. A complex, comprising: an antagonist peptide and at least one thrombospondin protein, the peptide comprising: the sequence consisting of: R1-R2-R3-Ser-Gln-Leu-Leu-Lys-Gly-R4-R5-R6 (SEQ ID NO:3), wherein R1 is selected from a group consisting of: Ile, Cys, Leu, Val, and Ala, wherein R2 is selected from a group consisting of: Glu and Asp, wherein R3 is selected from a group consisting of: Ile, Leu, Val, and Ala, wherein R4 is selected from a group consisting of: Glu and Asp, wherein R5 is selected from a group consisting of: Ile, Leu, Val, and Ala, wherein R6 is selected from a group consisting of: Ser, Thr and Cys, wherein said antagonist peptide is formed by artificial synthesis; and wherein said at least one thrombospondin protein is selected from the group consisting of thrombospondin-1 and thrombospondin-2, and wherein said complex prevents an interaction between a CD47 receptor and the thrombospondin protein, the antagonistic peptide bound to a C-terminal domain of the thrombospondin protein, wherein the antagonistic peptide is a loop, said loop aligning the antagonistic peptide to the C-terminal domain on the thrombospondin protein, and wherein said loop is cyclized by an amide bond.