Patent ID: 9657047
Date: 2017-05-23
CPC Classifications: A61P,C07H

Claim:
1. A method for producing crystalline epirubicin hydrochloride, comprising steps of: (a) providing epirubicin hydrochloride; (b) combining the epirubicin hydrochloride provided in step (a), at least one first alcohol selected from the group consisting of 1-butanol, 2-butanol, and 1-pentanol, and at least one second alcohol which is 2-propanol to produce a mixture containing the epirubicin hydrochloride, the at least one first alcohol, the at least one second alcohol and water, the water being provided in step (a) and/or step (b), a proportion of the epirubicin hydrochloride contained in the mixture being in the range of 10-50 g/l relative to the total volume of the mixture; and (c) crystallizing the epirubicin hydrochloride from the mixture produced in step (b) by heating the mixture produced in step (b) to a temperature in the range of 50-75° C. for a time period of at least 2 hours.