Patent ID: 9562010
Date: 2017-02-07
CPC Classifications: C07D,G01N

Claim:
1. An isotope labeled amine reactive cross-linker, comprising: a 3,3′-dithiobis(sulfosuccinimidyl sulfo propionate) molecule comprising a disulfide bond; and a deuterium label positioned on one side of the disulfide bond of the 3,3′-dithiobis(sulfosuccinimidyl sulfo propionate) molecule, wherein the deuterium label causes the 3,3′-dithiobis(sulfosuccinimidyl sulfo propionate) molecule to be structurally asymmetrical across the disulfide bond, wherein the disulfide bond can be dissociated, wherein dissociation of the disulfide bond creates a first and a second cleavage product, wherein one of the first or second cleavage products comprises the deuterium label, wherein the first and a second cleavage products differ in mass, and wherein the nominal mass of the cleavage products differs by 4 Daltons.