Patent ID: 9587014
Date: 2017-03-07
CPC Classifications: A61K,A61P,C07K,G01N

Claim:
1. A method of reducing the accumulation of pathological TDP-43 deposits or reducing pathological TAR-DNA-binding protein 43 kDa (TDP-43) distribution in a human subject in need thereof, comprising administering to the subject an effective amount of an anti-TDP-43 monoclonal antibody comprising a heavy chain variable (VH) region comprising the amino acid sequences of SEQ ID NO:131 (VH CDR1), SEQ ID NO:132 (VH CDR2), and SEQ ID NO:133 (VH CDR3) and a light chain variable (VL) region comprising the amino acid sequences of SEQ ID NO:135 (VL CDR1), SEQ ID NO:136 (VL CDR2), and SEQ ID NO:137 (VL CDR3).