Patent ID: 9603890
Date: 2017-03-28
CPC Classifications: A61K,C12Q,G01N

Claim:
1. A method of increasing the concentration of co-administered drugs in an individual with a disease characterized by tissues with increased heparan sulfate moiety, the method comprising: a) screening an individual for increased levels of a heparin sulfate moiety selected from the group consisting of 2-O-sulfo-α-L-iduronic acid-2-deoxy-2-acetamido-α-D-glucopyranosyl, IdoA2S-GlcNS, heparinase I, and heparanase (HPSE); b) identifying the presence of a disease requiring treatment according to the increased levels of the compound detected in step a) wherein the disease is pulmonary hypertension (PAH); c) administering to said individual a peptide that targets the receptor IdoA2S-GlcNS and selectively penetrates the cells and extracellular matrix of diseased tissues wherein the peptide is selected from the group consisting of CAR (SEQ ID NO: 1) and tCAR (SEQ ID NO: 2); d) co-administering to said individual a drug for treatment of PAH with said peptide; and e) increasing the rate of macropinocytosis in the target cells.