Patent ID: 9670187
Date: 2017-06-06
CPC Classifications: A61P,C07C,C07D

Claim:
1. A method for preparing a compound of formula (A), a salt thereof, or solvate thereof: comprising the steps of: (a) contacting a compound of formula (I), stereoisomer thereof, or mixture of stereoisomers thereof: with a compound of formula (J) or salt thereof: under conditions sufficient to yield a compound of formula (G), stereoisomer thereof, or mixture of stereoisomers thereof: (b) contacting the compound of formula (G) with a compound of formula (H) or salt thereof: under conditions sufficient to yield a compound of formula (B), stereoisomer thereof, or mixture of stereoisomers thereof: (c) cyclizing a compound of formula (B) under conditions sufficient to yield a compound of formula (C): (d) dehydrogenating the compound of formula (C) under conditions sufficient to yield a compound of formula (D): wherein the reaction conditions of step (d) comprise an additive selected from the group consisting of a carbonate base, an amine, an acid, and an acetate salt; (e) deprotecting the compound of formula (D) under conditions sufficient to yield a compound of formula (E) or a salt thereof: and (f) contacting the compound of formula (E) with a compound of formula (F): under conditions sufficient to yield a compound of formula (A), wherein PG is an amine protecting group, X and Y are each independently selected from the group consisting of halo, —OSO 2 R, OP(O)OR, and OP(O)(OR) 2 , wherein R is alkyl, haloalkyl, aryl, or substituted aryl.