Patent ID: 9655898
Date: 2017-05-23
CPC Classifications: A61K,A61P

Claim:
1. A long term storage stable pemetrexed-containing aqueous liquid pharmaceutical composition, comprising: a) pemetrexed or a pharmaceutically acceptable salt thereof; b) 1 mg/ml to about 20 mg/ml L-methionine; and c) 0.005M to about 0.5M sodium citrate, tribasic; and d) an aqueous pharmaceutically acceptable fluid; and optionally e) propylene glycol; wherein the composition has a pH of from about 8.0 to about 9.5; and said pemetrexed-containing composition has less than about 5% total impurities, on a normalized peak area response (“PAR”) basis as determined by high performance liquid chromatography (“HPLC”) at a wavelength of 227 nm, after at least about 18 months of storage at a temperature of from about 5° C. to about 25° C.