Patent ID: 9533980
Date: 2017-01-03
CPC Classifications: A61K,A61P,C07D,C12Q,G01N

Claim:
1. A method of treating a subject having cancer, the method comprising administering a therapeutically effect amount of an IAP inhibitor to the subject having cancer when the level of NOL3 expression measured in a cancer cell-containing sample from the subject having cancer is lower than a reference level of NOL3 expression measured in a sample from a subject without the cancer; wherein the IAP inhibitor is a compound of formula (II) or pharmaceutically acceptable salts thereof, wherein R R R A is 5- or 6-membered heteroaryl containing 1-4 ring heteroatoms selected from the group consisting of nitrogen, oxygen, and sulfur, the heteroaryl being unsubstituted or substituted with lower alkyl, amino, or halo; D is O, C(O), or NCH A M is H; and n is 0.