Patent ID: 9567342
Date: 2017-02-14
CPC Classifications: A61K,A61P,C07D

Claim:
1. A method for inhibiting anaplastic lymphoma kinase in a cell, comprising contacting the cell with an effective amount of at least one compound of formula (I): and/or at least one pharmaceutically acceptable salt thereof, or at least one pharmaceutical composition thereof, wherein each R hydrogen, halogen, hydroxyl, C C C heterocyclyl, heterocyclylalkyl aryl, arylalkyl, heteroaryl, or heteroarylalkyl, wherein alkyl, cycloalkyl, and heterocyclyl are each unsubstituted or substituted with at least one substituent independently selected from R each R C wherein alkyl and piperidinyl are each unsubstituted or substituted with at least one substituent independently selected from R each R hydrogen, halogen, —CN, —NR C wherein alkyl is unsubstituted or substituted with at least one substituent independently selected from R each R hydrogen, halogen, —CN, C C C C wherein C or R each R C C C C —OR —NR —NO halogen, —S(O) —SR —S(O) —OS(O) —S(O) —NR —O(CR —C(O)R —CO —CO —OC(O)R —CN, —C(O)NR —NR —OC(O)NR —NR —NR —CR —CHF —CF —OCHF —OCF wherein C each R C C C C —OR —NR —NO halogen, —S(O) —SR —S(O) —OS(O) —S(O) —NR —(CR —(CR —(CR —(CR —(CR —(CR —(CR —(CR —(CR —(CR —O(CR —C(O)R —C(O)(CR —C(O)(CR —C(O)(CR —C(O)(CR —CO —CO —OC(O)R —CN, —C(O)NR —NR —OC(O)NR —NR —NR —CR —CHF —CF —OCHF —OCF each R R aryl, aryl-C heteroaryl, or heteroaryl-C each R hydrogen, C C C C cycloalkyl-C heterocyclyl, heterocyclyl-C aryl, heteroaryl, aryl-C heteroaryl-C wherein alkyl, alkenyl, alkynyl, cycloalkyl, and heterocyclyl are each unsubstituted or substituted with at least one substituent independently selected from R R each R hydrogen, C C C C cycloalkyl-C heterocyclyl, heterocyclyl-C aryl, heteroaryl, aryl-C heteroaryl-C R each R hydrogen, C C C heterocyclyl, heterocyclyl-C aryl, aryl-C heteroaryl, heteroaryl-C —S(O) —C(O)R —CO —CO —C(O)NR each R halogen, C C C heterocycyl, heterocyclyalkyl, aryl, aryl-C heteroaryl, heteroaryl-C —OR —NR —S(O) —SR —S(O) —OS(O) —S(O) —NR —O(CR —C(O)R —CO —CO —OC(O)R —CN, —C(O)NR —NR —OC(O)NR —NR —NR —CHF —CF —OCHF —OCF each m is independently 0, 1 or 2; each n is independently 1, 2, or 3; each p is independently 2; each q is independently 0, 1, 2, or 3; each r is independently 1 or 2; each t is independently 1, 2, or 3.