Patent ID: 9561233
Date: 2017-02-07
CPC Classifications: A61K

Claim:
1. A method for treating pain in a patient, comprising administering to the patient a dosage of a compound selected from ibogaine, an ibogaine derivative, and a pharmaceutically acceptable salt and/or solvate thereof, wherein the ibogaine derivative is selected from the group consisting of coronaridine, voacangine, 18-methoxy coronaridine, 2-methoxyethyl-18-methoxycoronaridinate, 18-methylaminocoronaridine, 16-hydroxymethyl-18-hydroxyibogaline, 16-hydroxymethyl-18-methoxylibogaline, 16-ethoxycarbonyl-18-hydroxyibogaline laurate, and 16-ethoxycarbonyl-18-hydroxyibogaline methoxyethoxymethyl ether, wherein the administering provides an average serum concentration of less than about 250 ng/mL of the compound, said concentration being sufficient to alleviate and/or inhibit said pain while maintaining a QT interval of less than about 500 ms during said treatment.