Patent ID: 9540443
Date: 2017-01-10
CPC Classifications: A61K,A61P,C07K,C12N,G01N

Claim:
1. An isolated antibody or an antigen-binding fragment thereof, which immunospecifically binds to a D4/D5 region of human KIT (SEQ ID NO: 15), comprising: (i) a variable light (“VL”) chain region comprising a VL CDR1, VL CDR2, and VL CDR3 comprising the amino acid sequences of SEQ ID NO: 20, SEQ ID NO: 21, and SEQ ID NO: 22, respectively; and (ii) a variable heavy (“VH”) chain region comprising a VH CDR1, VH CDR2, and VH CDR3 comprising the amino acid sequences of SEQ ID NO: 23, SEQ ID NO: 24, and SEQ ID NO: 25, respectively.