Patent ID: 9610269
Date: 2017-04-04
CPC Classifications: A61K,A61P

Claim:
1. A method of treating spasticity; said method comprising orally administering once-a-day in the evening a gastric retention controlled release drug delivery system comprising baclofen or its pharmaceutically acceptable salt and pharmaceutically acceptable excipients wherein the gastric retention controlled release drug delivery system comprises a first composition, a second composition and a third composition, wherein the first composition comprises an immediately releasing fraction of the baclofen dose and surrounds the third composition; the second composition comprises a first region comprising a slow release fraction of the total dose of baclofen present in the gastric retention controlled release drug delivery system and excipients filled into hard gelatin capsule, and a second region which is a sub-coating applied on the filled hard gelatin capsule and the second region comprises swellable polymers, gas generating agent and superdisintegrants and does not contain baclofen further wherein at least one swellable polymer is a polymer obtained by polymerization of the monomers, butyl methacrylate, 2-dimethyl aminoethyl methacrylate and methyl methacrylate and is soluble below about pH 5 and swellable and permeable above pH 5; the third composition comprises methacrylic acid copolymer Type C, polycarbophil, gas generating agent and superdisintegrants and mixtures thereof.