Patent ID: 9642899
Date: 2017-05-09
CPC Classifications: A01K,A61K,A61P,C12N

Claim:
1. A method for providing a primate with a cardiac xenograft, said method comprising implanting said cardiac xenograft into said primate, wherein said xenograft is from a transgenic pig whose genome comprises disrupted β1,4 N-acetyl-galactosaminyl transferase 2 (B4GALNT2) nucleotide sequences and disrupted α-1-3 galactosyl transferase (GT) glycosyltransferase nucleotide sequences, wherein said xenograft has at least 50 percent less expression of a-Gal antigen as compared to the level of a-Gal antigen expression by a control, non-transgenic pig, and wherein said xenograft has at least 50 percent less expression of an Sd a antigen as compared to the level of Sd a antigen expression by a control, non-transgenic pig, wherein said xenograft exhibits reduced immunogenicity when implanted into said primate as compared to a cardiac xenograft from a wild-type pig, and wherein the primate is immunosuppressed.