Patent ID: 9574241
Date: 2017-02-21
CPC Classifications: A61K,C12Q

Claim:
1. A method, comprising (a) providing a biological sample from a subject that has lymphoma; (b) analyzing the biological sample to detect for presence of RHOA p.Glyl7Val mutation, (c) determining that the subject has Peripheral T-Cell Lymphoma if RHOA p.Glyl7Val mutation, is detected in the biological sample and (d) if it is determined that the subject has an increased risk of developing Peripheral T-Cell Lymphoma due to the presence of a mutation selected from the group consisting of FYN p.Leu174Arg, FYN p.Arg176Cys, and FYN p.Tyr531His, then prophylactically treating the subject for Peripheral T-Cell Lymphoma by administering a therapeutically effective amount of an SRC kinase inhibitor.