Patent ID: 9687570
Date: 2017-06-27
CPC Classifications: A61K,B01F

Claim:
1. A method of producing lipid-based bubbles, comprising steps of: preparing a lipid mixture comprising a first lipid, or two or more first lipids with different phase transition temperature, a second lipid bonding with a hydrophilic polymer moiety and optionally one or more molecules capable of getting across a lipid membrane and decreasing van der Waals forces between lipid bilayers; wherein each of the first lipids includes a hydrophobic C8-C30 end, and the hydrophilic polymer moiety has a long chain with molecular weight of 200-200,000; emulsifying the lipid mixture with an aqueous solvent by mechanical means to form a transparent lipid carrier solution and then adjusting the transparent lipid carrier to 20 Celsius degree; placing the transparent lipid carrier solution in a closed vessel comprising a predetermined gas; manipulating temperature of the transparent lipid carrier solution to be close to a main phase transition temperature of the transparent lipid carrier solution while agitating in a mechanical manner the closed vessel containing the transparent lipid carrier solution to form said bubbles within the closed vessel.