Patent ID: 9682068
Date: 2017-06-20
CPC Classifications: A61F,A61K,A61P

Claim:
1. A transdermal therapeutic system (TTS) for the administration of one or more active ingredients selected from the group consisting of pramipexole, pharmaceutically acceptable pramipexole salts, and pharmaceutically acceptable pramipexole derivatives, the system comprising: (i) a substantially active-ingredient-impermeable backing layer, (ii) at least one matrix layer which contains at least about 5% to 10% w/w active ingredient(s), and (iii) a substantially impermeable protective release liner layer which releasably contacts the matrix layer or other adhesive layer; wherein 1) the matrix layer comprises an adhesive selected from acrylate-based adhesive and silicone-based adhesive, 2) the transdermal therapeutic system provides a therapeutically effective administration of the active ingredient(s), at a flux rate ranging from 1 μg/cm 2 /hr to 4.6 μg/cm 2 /hr between the 96 th and 168 th hour after treatment is initiated, and 3) the matrix layer is color-stable and lacks crystal growth of the active ingredient, over an extended storage period of at least one of 30 or more days, 90 or more days, and 180 or more days.