Patent ID: 9586912
Date: 2017-03-07
CPC Classifications: C07D

Claim:
1. A preparation method of the 2-substituted-2H-1,2,3-triazole derivative having the following structure: wherein R represents alkyl, aryl, aralkyl, cycloalkyl, cycloalkyl alkyl, heteroaryl, heteroaryl alkyl, or heterocycloalkyl; X represents chlorine or iodine, the method comprising the following steps: dissolving the compound shown in the following formula III in mass to volume ratio of 1:2 to 20 of diethyl ether, tetrahydrofuran or 1,4-dioxane or methyltetrahydrofuran, cooling to −78 to 0° C., adding isopropylmagnesium chloride or isopropylmagnesium chloride-lithium chloride composite, stirring for 0.5 to 2 hours, inleting chlorine or adding N-chlorosuccinimide, 1,3-dichloro-5,5-dimethylhydantoin, or adding iodine, stirring for 5 to 30 minutes, heating up to room temperature, extracting by using organic solvent after quenching by using saturated ammonium chloride aqueous solution, drying via anhydrous sodium sulfate or anhydrous magnesium sulfate, concentrating to dry under reduced pressure, recrystallizing the obtained concentrate to obtain the 2-substituted-2H-1,2,3-triazole derivative; wherein R represents alkyl, aryl, aralkyl, cycloalkyl, cycloalkyl alkyl, heteroaryl, heteroaryl alkyl, or heterocycloalkyl.