Patent ID: 9631005
Date: 2017-04-25
CPC Classifications: A61K,A61P,C07K,C12N

Claim:
1. A method of treating a patient to promote the repair of damaged tissue, the method comprising administering locally to the damaged tissue an isolated mutant form of stromal cell derived factor-1 (SDF-1) peptide consisting of SEQ ID NO:54; and wherein said mutant form of the SDF-1 peptide consisting of SEQ ID NO:54 has chemoattractant activity for T cells and is inactivated by matrix metalloproteinase-2 (MMP-2) at a rate that is less than one-half of the rate at which native SDF-1 peptide is inactivated, and said mutant form of the SDF-1 peptide consisting of SEQ ID NO:54 has chemoattractant activity for T cells and is inactivated by dipeptidyl peptidase IV (DPPIV) at a rate that is less than one-half of the rate at which native SDF-1 peptide is inactivated.