Patent ID: 9738724
Date: 2017-08-22
CPC Classifications: A61K,C07K

Claim:
1. An isolated antibody of the IgG class comprising a heavy chain and a light chain wherein: a. the light chain has one or more non-natural amino acid residues at specific sites selected from the group consisting of light chain residues 7 and 22 according to the Kabat numbering scheme; and/or b. the heavy chain has one or more non-natural amino acid residues at specific sites selected form the group consisting of heavy chain residues 19, 25, 40, and 70 according to the Kabat numbering scheme and heavy chain residues 121, 180, and 190 according to the EU index of Kabat; or an aglycosylated variant thereof, wherein each non-natural amino acid residue is independently selected from the group consisting of ortho-substituted tyrosine, meta substituted tyrosine, para-substituted phenylalanine, ortho-substituted phenylalanine, and meta-substituted phenylalanine.