Patent ID: 9657287
Date: 2017-05-23
CPC Classifications: A61K,A61P,C07K,C12N

Claim:
1. A method for the construction of a collection of nucleic acid molecules, comprising the steps of (a) identifying a repeat unit from a repeat protein family; (b) identifying framework residues and target interaction residues in said repeat unit; (c) deducing a repeat module comprising fixed positions and randomized positions from at least one member of said repeat protein family; and (d) constructing nucleic acid molecules each encoding a repeat protein comprising a repeat domain, wherein said repeat domain comprises two or more copies of said repeat module deduced in step (c), wherein the collection of nucleic acid molecules encodes a collection of repeat proteins, and wherein said repeat proteins differ from each other in at least one position of said two or more copies of said repeat module deduced in step (c).