Patent ID: 9623413
Date: 2017-04-18
CPC Classifications: B01J,B01L,C12M,C30B,Y10T

Claim:
1. A method of conducting a reaction at a selected temperature or range of temperatures over time, the method comprising: providing an array device comprising (i) a plurality of separate reaction chambers, each chamber comprising a chamber bottom, and (ii) a bottom surface, wherein a thermal transfer element is bonded to the bottom surface, the thermal transfer element being formed to contact a thermal control device and adapted to create a homogeneous thermal field for the plurality of separate reaction chambers, wherein the array device includes an elastomeric valve actuatable to control fluidic actions within the array device; introducing into the array device reagents for carrying out a desired reaction; and contacting the thermal transfer element with the thermal control device such that the thermal control device is in thermal communication with the thermal transfer element and so that a temperature of the reaction in the plurality of separate reaction chambers is homogeneously changed by the homogeneous thermal field as a result of a change in temperature of the thermal control device, wherein the thermal control device is adapted to apply a force to the thermal transfer element to urge the thermal transfer element towards the thermal control device without actuating the valve.