Patent ID: 9597412
Date: 2017-03-21
CPC Classifications: A61K,A61L,A61P

Claim:
1. A method for enhancing cartilage repair in a subject in need thereof, wherein the subject has impaired cartilage, comprising administering to the subject at the site in need of treatment an effective amount of a pharmaceutical composition comprising a growth factor bound to hyaluronic acid (HA)-based hydrogel particles, wherein the hyaluronic acid (HA)-based hydrogel particles are conjugated with a heparan sulfate proteoglycan (HSPG), wherein the growth factor is bone morphogenetic protein 2 (BMP2), wherein the heparan sulfate proteoglycan (HSPG) comprises perlecan domain 1 (PlnD1), and wherein the composition comprises 0.1-10 μg/ml of the BMP2 and 1-10 mg/ml of the hyaluronic acid (HA)-based hydrogel particles conjugated with the perlecan domain 1 (PlnD1).