Patent ID: 9580501
Date: 2017-02-28
CPC Classifications: A61K,A61P,C07K,C12N

Claim:
1. A monoclonal secretory IgA antibody, which binds to and neutralizes human TNFα, wherein said antibody comprises: (a) a heavy chain constant region having a sequence selected from the group consisting of SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12 and SEQ ID NO:13, a heavy chain variable region having the sequence of SEQ ID NO:2, and a light chain variable region having the sequence of SEQ ID NO:3; or (b) a heavy chain constant region having a sequence selected from the group consisting of SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12 and SEQ ID NO:13, a heavy chain variable region having the sequence of SEQ ID NO:4, and a light chain variable region having the sequence of SEQ ID NO: 5.