Patent ID: 9573941
Date: 2017-02-21
CPC Classifications: C07D

Claim:
1. A process for preparing adihydropyrimidine compound having Formula (I), or a tautomer thereof having Formula (Ia), wherein each R R R Z is —O—, —S—, —S(═O) Y is —O—, —S—, —S(═O) each t and q is independently 0, 1, or 2; each of R each R each R each R each R R n is 0, 1, 2, 3, 4, or 5; each m is independently 0, 1, 2, 3, or 4; f is 1, 2, 3, or 4; and j is 0, 1, or 2; wherein the process comprises the steps of: step (A): reacting an amidine compound of Formula (II), or a salt thereof with an aldehyde compound of Formula (III) and a compound of Formula (IV) in a first organic solvent to obtain a compound of Formula (V), wherein R R step (B): halogenating the compound of Formula (V) in a third organic solvent to form a halide; and then reacting the halide with a compound of Formula (VI), or a salt thereof to obtain a compound of Formula (VII),  and step (C): forming the compound of Formula (I) or Formula (Ia) from the compound of Formula (VII) by means of a transesterification.