Patent ID: 9540449
Date: 2017-01-10
CPC Classifications: A61K,A61P,C07K

Claim:
1. An isolated antibody or antigen-binding fragment thereof that binds human proprotein convertase subtilisin/kexin type 9 (PCSK9), wherein the acidic/neutral K D ratio for the antibody or antigen-binding fragment binding to PCSK9 at 25° C. is greater than about 12.5 as determined by surface plasmon resonance; wherein the antibody or antigen-binding fragment thereof comprises 3 heavy chain complementarity determining regions (HCDR1, HCDR2 and HCDR3) and 3 light chain complementarity determining regions (LCDR1, LCDR2 and LCDR3), wherein the HCDR1 comprises the amino acid sequence of SEQ ID NO: 220; wherein the HCDR2 comprises the amino acid sequence of SEQ ID NO: 222; wherein the HCDR3 comprises the amino acid sequence selected from the group consisting of SEQ ID NOs: 224 and 788; wherein the LCDR1 comprises the amino acid sequence of SEQ ID NO: 802; wherein the LCDR2 comprises the amino acid sequence of SEQ ID NO: 230; and wherein the LCDR3 comprises the amino acid sequence of SEQ ID NO: 232.