Patent ID: 9624156
Date: 2017-04-18
CPC Classifications: A61K,A61P,C07C,C07F

Claim:
1. A method of treating pulmonary hypertension comprising administering to a human subject with pulmonary hypertension an effective amount of a compound of formula or a pharmaceutically acceptable salt thereof, wherein R 1 is a substituted or unsubstituted alkyl, R 2 and R 3 are the same or different and are independently selected from the group consisting of H, phosphate, and groups wherein OR 2 and OR 3 form esters of amino acids or proteins; wherein said unsubstituted alkyl is selected from the group consisting of: a) an unbranched alkyl selected from the group consisting of pentyl, hexyl, heptyl, octyl, nonyl, decyl, undecyl, and dodecyl; b) a branched alkyl selected from the group consisting of —CH(CH 3 )(CH 2 CH 3 ), —CH(CH 2 CH 3 ) 2 , —C(CH 3 ) 3 , —C(CH 2 CH 3 ) 3 , —CH 2 CH(CH 3 ) 2 , —CH 2 CH(CH 3 )(CH 2 CH 3 ), —CH 2 CH(CH 2 CH 3 ) 2 , —CH 2 C(CH 3 ) 3 , —CH 2 C(CH 2 CH 3 ) 3 , —CH(CH 3 )CH(CH 3 )(CH 2 CH 3 ), —CH 2 CH 2 CH(CH 3 ) 2 , —CH 2 CH 2 CH(CH 3 )(CH 2 CH 3 ), —CH 2 CH 2 CH(CH 2 CH 3 ) 2 , —CH 2 CH 2 C(CH 3 ) 3 , —CH 2 CH 2 C(CH 2 CH 3 ) 3 , —CH(CH 3 )CH 2 CH(CH 3 ) 2 , —CH(CH 3 )CH(CH 3 )CH(CH 3 ) 2 , and —CH(CH 2 CH 3 )CH(CH 3 )CH(CH 3 )(CH 2 CH 3 ); c) a cyclic alkyl selected from the group consisting of cyclopentyl, cyclohexyl, cycloheptyl, and cyclooctyl; and d) a polycyclic alkyl group, wherein said substituted alkyl is an unsubstituted alkyl as defined above in which one or more bonds to one or more carbon or hydrogen atoms are replaced by a bond to an atom selected from F, Cl, Br, I, O, S, N and Si.