Patent ID: 9539313
Date: 2017-01-10
CPC Classifications: A61K,A61P,C07K,C12N,C12Y,Y02A

Claim:
1. A method of imparting immunity against a tumor, a bacterium, or a virus in a subject, the method comprising administering to said subject a recombinant Salmonella bacterium comprising a nucleic acid encoding a fusion protein comprising an antigen of the tumour, an antigen of the bacterium, or an antigen of the virus, and an N-terminal secretion signal from a type III secretion domain, wherein the N-terminal secretion signal consists of SEQ ID NO: 2, and wherein the method results in the translocation of the antigen to the cytosol of macrophages and/or dendritic cells of the subject leading to the activation of the antigen-specific CD8+ T cells in said subject.