Patent ID: 9726677
Date: 2017-08-08
CPC Classifications: A61P,C12Q,G01N

Claim:
1. A method of determining an expression level of each of a plurality of fibrotic pulmonary disease marker proteins in a subject that has or is at risk for developing a fibrotic pulmonary disease, said method comprising: (i) obtaining a biological sample from said subject; (ii) contacting each of said plurality of fibrotic pulmonary disease marker proteins with a marker protein binding agent for each of said plurality of fibrotic pulmonary disease marker proteins in said biological sample thereby forming disease marker protein-binding agent complexes; and (iii) detecting said disease marker protein-binding agent complexes thereby determining an expression level of each of said plurality of fibrotic pulmonary disease marker proteins in said biological sample, wherein said plurality of fibrotic pulmonary disease marker proteins consists of TIMP-1, MMP-7, PTN, Activin A, HGF, Midkine, SIEGE-121, PDE3A, SBDS, DKK-4, SICAM-5, SREC-I, ERIK-1, DKK-1, α2-Macroglobulin, NAGK, UFC1 and SGTA.