Patent ID: 9650437
Date: 2017-05-16
CPC Classifications: A61K,A61P,C07K

Claim:
1. An isolated nucleic acid encoding an IL-17A and IL-17F cross-reactive antibody, or an antigen-binding fragment thereof, wherein the antibody heavy chain variable region comprises a VH CDR1 sequence comprising the amino acid sequence of SEQ ID NO:85; a VH CDR2 sequence comprising the amino acid sequence of SEQ ID NO: 94; and a VH CDR3 sequence comprising the amino acid sequence of SEQ ID NO: 95; and the antibody light chain variable region comprises a VL CDR1 sequence comprising the amino acid sequence of SEQ ID NO:110; a VL CDR2 sequence comprising the amino acid sequence of SEQ ID NO:97; and a VL CDR3 sequence comprising the amino acid sequence of SEQ ID NO:111.