Patent ID: 9650244
Date: 2017-05-16
CPC Classifications: A61K,B82Y

Claim:
1. A method of inducing an immune response in a non-rodent mammal, comprising topically administering to said non-rodent mammal an effective amount of a composition comprising non-viral nanoparticles comprising: (a) a micelle core comprising an antigen that is a DNA plasmid and a surfactant that has an HLB value of less than or equal to about 6.0, (b) a shell adsorbed to the micelle core and comprising a ligand, lithium, and an adjuvant, wherein the ligand comprises hyaluronan with an average molecular weight of between about 5,000 and 30,000 Daltons that is non-covalently attached to the nanoparticles, wherein the nanoparticles have a mean diameter of less than about 50 nanometers, wherein topically administering the composition stimulates a cytokine.