Patent ID: 9731025
Date: 2017-08-15
CPC Classifications: A61K,C12N

Claim:
1. A method for delivering a nucleic acid drug to the liver of a vertebrate, the method comprising: inducing the formation of endogenous lipoprotein particles in the vertebrate; and administering a pharmaceutical composition to the large intestine of the vertebrate, wherein the pharmaceutical composition comprises: (a) the nucleic acid drug covalently bound to Vitamin E, and (b) a composition that enhances epithelial permeability of the nucleic acid drug through the mucosal epithelium of the large intestine, comprising polyoxyethylene hydrogenated castor oil and at least one compound selected from linoleic acid, oleic acid, linolenic acid, docosahexaenoic acid, and eicosapentaenoic acid; and wherein the nucleic acid drug is specifically delivered to the liver and the nucleic acid drug exerts a physiologically active effect at least in the liver.