Patent ID: 9657301
Date: 2017-05-23
CPC Classifications: C07K,C12N,C12P,C12R

Claim:
1. A mutant of a parent filamentous fungal cell, the parent organism having a preference for non-homologous recombination (NHR), wherein the filamentous fungal host cell is a Penicillium species, wherein the ratio of NHR/homologous recombination (HR) is decreased in the mutant as compared to said ratio in said parent organism measured under the same conditions, wherein the mutant is deficient in a gene encoding a component involved in NHR, and/or has a decreased level of a component involved in NHR, wherein the mutant is, optionally inducibly, deficient in at least one filamentous fungal homologue of yeast KU80, yeast KU70, or both, or has, optionally inducibly, a decreased amount of at least one of the proteins encoded by these genes.