Patent ID: 9610349
Date: 2017-04-04
CPC Classifications: A61K

Claim:
1. A method of inducing specific immune tolerance to myelin in an individual in need thereof, the method comprising introducing directly into a lymph node of the individual an effective amount of a composition comprising a myelin antigen, a biodegradable polymer and at least one tolerogenic agent such that tolerance to the myelin antigen in the individual is induced, the composition not comprising any surface ligand that specifically targets the composition to any cell or tissue, wherein the introducing into the lymph node is performed only a single time, and wherein subsequent to the single introducing: i) there is a systemic reduction of secretion of inflammatory cytokines in the individual, ii) the ratio of T regulatory cells to T effector cells in the spleen of the individual is increased, and iii) the amount of IFN-γ secreted by lymph node cells and the amount of IFN-γ secreted by spleen cells of the individual is lower than a control amount of IFN-γ secreted from lymph node cells and spleen cells subsequent to a single intramuscular administration of the composition.