Patent ID: 9567382
Date: 2017-02-14
CPC Classifications: A61P,C07K

Claim:
1. An expression vector for expression of rod-derived cone viability factor (RdCVF) comprising a) a RdCVF-encoding nucleotide sequence; b) a signal peptide-encoding nucleotide sequence positioned upstream of the RdCVF-encoding nucleotide sequence, wherein the signal peptide-encoding sequence encodes the signal peptide of insulin growth factor-1 (IGF-1) and directs secretion of expressed RdCVF; and c) a nucleotide sequence encoding a furin cleavage marker located downstream of the signal peptide-encoding nucleotide sequence and upstream of the RdCVF-encoding nucleotide sequence, wherein the signal peptide-encoding sequence and the furin cleavage marker sequence are separated by a nucleotide sequence encoding SEQ ID NO: 1.