Patent ID: 9532555
Date: 2017-01-03
CPC Classifications: A01K,A61P,C12N,C12Q,C12Y,G01N

Claim:
1. A transgenic mouse whose genome comprises a homozygous or heterozygous replacement of a mouse Dipeptidyl peptidase IV (DPP4) exons 2 to 26 with a human genomic segment comprising human Dpp4 exons 2 to 26 to form a humanized Dpp4 encoding gene, wherein the replacement is at an endogenous mouse Dpp4 locus, wherein the humanized Dpp4 encoding gene is under control of the endogenous mouse Dpp4 promoter at said endogenous Dpp4 locus; and wherein said mouse when infected with Middle East respiratory syndrome coronavirus (MERS-CoV) exhibits lung inflammation.