Patent ID: 9566234
Date: 2017-02-14
CPC Classifications: A61K,A61M,A61P

Claim:
1. A system for treating or providing prophylaxis against a pulmonary infection in a patient, comprising: (a) a pharmaceutical formulation comprising an aqueous dispersion of liposomal complexed aminoglycoside, wherein the lipid component of the liposomal complexed aminoglycoside is present at 45-60 mg/mL and consists of dipalmitoylphosphatidylcholine (DPPC) and cholesterol, and (b) a nebulizer comprising a vibrating mesh membrane, which generates an aerosol of the pharmaceutical formulation at a rate of 0.60 g per minute to 0.80 g per minute, wherein the fine particle fraction (FPF) of the aerosol is greater than or equal to about 64%, as measured by the Andersen Cascade Impactor (ACI), or greater than or equal to about 51%, as measured by the Next Generation Impactor (NGI) and the percent associated aminoglycoside of the aerosol is from 60% to 70%.