Patent ID: 9642894
Date: 2017-05-09
CPC Classifications: A61K,A61P

Claim:
1. A composition for parenteral administration consisting essentially of: (a) about 0.45 wt. % of a glucagon peptide which has been dried in a non-volatile glycine buffer, and wherein the glucagon peptide has a pH memory that is about equal to the pH of the glucagon peptide in the non-volatile buffer, wherein the pH memory is between 2.5 to 3.5; (b) about 92 wt. % to 96 wt. % of an aprotic polar solvent, wherein the peptide is solubilized in the aprotic polar solvent, and wherein the aprotic polar solvent is dimethyl sulfoxide (DMSO); (c) about 3 wt. % to 7 wt. % of trehalose; (d) glycine; and (e) optionally hydrochloric acid, wherein the moisture content of the composition is less than 5 wt. %.