Patent ID: 9730435
Date: 2017-08-15
CPC Classifications: A01K,C07K,C12N,G01N

Claim:
1. A genetically modified mouse whose genome comprises a replacement of a mouse genomic fragment comprising exons 2-5 of an endogenous mouse A PRoliferation-Inducing Ligand (April) gene with a human genomic segment comprising exons 2-6 of a human APRIL gene to form a humanized April gene, wherein the replacement is at an endogenous mouse April locus; wherein the humanized April gene is under control of a mouse April promoter at said endogenous mouse April locus, and encodes a humanized April protein comprising an extracellular portion of the human APRIL protein encoded by said human APRIL gene linked to an intracellular portion of the mouse April protein encoded by said mouse April gene; wherein the coding exons of said humanized April gene consist of exon 1 of said endogenous mouse April gene and exons 2-6 of said human APRIL gene; and wherein said genetically modified mouse expresses said humanized April protein.