Patent ID: 9683022
Date: 2017-06-20
CPC Classifications: A61K,A61P,C07K,C12N

Claim:
1. A composition comprising a purified human Cytomegalovirus (HCMV) pentameric complex comprising: a pentamer-forming fragment of HCMV gH having a truncated transmembrane (TM) domain and a truncated ectodomain as compared to wild-type HCMV gH; HCMV gL or pentamer-forming fragment thereof; HCMV pUL128 or pentamer-forming fragment thereof; HCMV pUL130 or pentamer-forming fragment thereof; and HCMV pUL131A or pentamer-forming fragment thereof, wherein the truncated TM domain consists of an amino acid sequence having a deletion of the amino acids corresponding to residues 718 to 736 of wild-type sequence SEQ ID NO: 1, and wherein the truncated ectodomain consists of an amino acid sequence having a deletion of the amino acids corresponding to residues 716 and 717 of wild-type sequence SEQ ID NO: 1.