Patent ID: 9623030
Date: 2017-04-18
CPC Classifications: A61K,A61M,A61P

Claim:
1. A method for reducing surgical site infection in a patient during a medical surgical procedure, comprising administering by tumescent delivery to a subcutaneous compartment of a surgical site in the patient a tumescent antibiotic composition, comprising: (a) an antibiotic component; (b) lidocaine, wherein the concentration of lidocaine is approximately 100 mg to 1,500 mg per L of solution; (c) a vasoconstrictor component in an amount sufficient to cause intense subcutaneous vasoconstriction and to direct hydrostatic compression of capillaries and veins; and (d) a pharmaceutically acceptable carrier, wherein a mass of the tumescent antibiotic composition remains in the patient and is isolated from systemic circulation in the patient by virtue of capillary vasoconstriction, wherein only components of the mass of tumescent antibiotic composition that are located at the outer boundary of the mass of tumescent antibiotic composition are available for absorption, whereas the portion of the tumescent antibiotic composition located within the central portion of the mass of fluid is isolated from systemic circulation by the capillary vasoconstriction, thereby reducing risk of systemic toxicity from elevated serum levels of the antibiotic component and/or the lidocaine.