Patent ID: 9624280
Date: 2017-04-18
CPC Classifications: A61K,A61P,C07K,C12N

Claim:
1. An isolated Protoxin-II variant comprising the sequence X 1 X 2 X 3 CX 4 X 5 WX 6 QX 7 CX 8 X 9 X 10 X 11 X 12 CCX 13 X 14 FX 15 CX 16 LWCX 17 KKLW (SEQ ID NO: 403), wherein X X X X X X X X X X X X X X X X X optionally having an N-terminal extension or a C-terminal extension, wherein the polypeptide inhibits human Nav1.7 activity with an IC wherein the IC