Patent ID: 9611318
Date: 2017-04-04
CPC Classifications: A61P,C07K,Y02A

Claim:
1. An isolated monoclonal human antibody, or antigen-binding portion thereof, that binds specific to the first epidermal growth factor-like domain of MSP-10 (SEQ ID NO: 13) of Plasmodium falciparum , wherein said antibody or antigen-binding portion thereof inhibits the invasion of a Plasmodium falciparum parasite into the erythrocyte and/or the growth of the Plasmodium falciparum parasite within the erythrocyte by at least 50%, wherein the antibody or the antigen-binding portion thereof has a light chain variable region (LCVR) and a heavy chain variable region (HCVR), and wherein the LCVR comprises the CDR sequences of SEQ ID NOs 1, 2 and 3 and the HCVR comprises the CDR sequences of SEQ ID NOs 4, 5 and 6.