Patent ID: 9534254
Date: 2017-01-03
CPC Classifications: C12Q

Claim:
1. A method of cancer patient stratification into one of at least four cancer therapy groups comprising: (a) providing a diseased tissue or suspected disease tissue sample from a patient; (b) extracting chromosomal DNA from the tissue sample to produce a chromosomal DNA sample; (c) co-hybridizing the chromosomal DNA sample, labeled with a first fluorescent marker, and a reference DNA sample, labeled with a second fluorescent marker, to a nucleic acid microarray, said microarray comprising: (d) comparing a fluorescent ratio between colors of the first and second markers at a particular nucleic acid target element to provide a measurement of a copy number for genomic DNA sequences which are complementary to that nucleic acid target element; (e) stratifying the patient into one of the at least four cancer therapy groups selected from the group consisting of anti-HER-2/neu therapy, anti-EGFR therapy, anti-AKT1 therapy, anti-Topoisomerase II therapy, combination of anti-HER-2/neu therapy and anti-AKT1 therapy, and combination of anti-EGFR and anti-AKT1 therapy, based on presence or absence in at least one chromosomal gene amplification; and (f) performing a cancer therapy based on (e).