Patent ID: 9746477
Date: 2017-08-29
CPC Classifications: A61K,A61P,G01N

Claim:
1. A method of treating a patient suffering from lung cancer comprising: (a) quantifying the level of a specified FR-α fragment peptide and the level of a specified GART fragment peptide in a protein digest prepared from a tumor sample obtained from the patient and calculating the level of both the FR-α and GART peptides in said sample by selected reaction monitoring using mass spectrometry; (b) comparing the level of said FR-α fragment peptide to an FR-α reference level and comparing the level of said GART fragment peptide to a GART reference level, and (c) treating the patient with a therapeutic regimen comprising an effective amount of pemetrexed when the level of the GART fragment peptide is lower than said reference level and when the level of the FR-α fragment peptide is detected, and (d) treating the patient with a therapeutic regimen that does not comprise an effective amount of pemetrexed when the level of the GART fragment peptide is above said reference level and the FR-α fragment peptide is not detected.