Patent ID: 9745375
Date: 2017-08-29
CPC Classifications: A61K,A61P,C07K

Claim:
1. An isolated antibody or antigen-binding fragment thereof that specifically binds to a human LINGO-1 polypeptide, wherein the antibody or antigen-binding fragment comprises: an immunoglobulin heavy chain variable region (VH) comprising a complementarity determining region (CDR) 1, a CDR2, and a CDR3, wherein the CDR1 and the CDR2 of the VH are identical to the amino acid sequences of SEQ ID NO:6 and SEQ ID NO:7, respectively, and the CDR3 of the VH is identical to an amino acid sequence selected from the group consisting of SEQ ID NOs:35-49; an immunoglobulin light chain variable region (VL) comprising a CDR1, a CDR2, and a CDR3, wherein the CDR1, the CDR2, and the CDR3 of the VL are identical to the amino acid sequences of SEQ ID NO:14, SEQ ID NO:15 and SEQ ID NO:16, respectively.