Patent ID: 9540439
Date: 2017-01-10
CPC Classifications: A01K,A61K,A61P,C07K,C12N

Claim:
1. A method of inhibiting a function or decreasing stability of a regulatory T cell (Treg) while maintaining immune homeostasis in a subject, comprising: exposing the Treg in vivo to an anti-neuropilin-1 (NRP-1) antibody or antigen-binding fragment thereof which inhibits a neuropilin-1 (Nrp1): semaphorin-4 axis, wherein the anti-NRP-1 antibody or antigen-binding fragment thereof inhibits interaction between i) a transmembrane semaphorin-4 polypeptide on a cell expressing the transmembrane semaphorin-4 and ii) a NRP-1 polypeptide on the Treg.