Patent ID: 9663578
Date: 2017-05-30
CPC Classifications: A61K,A61P,C07K

Claim:
1. A method for inhibiting growth and/or proliferation of a tumor cell expressing CD32b, comprising administration, to an individual in need thereof, of an anti-CD32b antibody which comprises: a) a VH region comprising CDR1, 2 and 3 sequences as set forth in SEQ ID NO:2, 3 and 4, and a VL region comprising CDR1, 2 and 3 sequences as set forth in SEQ ID NO: 6, 7 and 8, b) a VH region comprising CDR1, 2 and 3 sequences as set forth in SEQ ID NO:10, 11 and 12, and a VL region comprising CDR1, 2 and 3 sequences as set forth in SEQ ID NO:14, 15 and 16, c) a VH region comprising CDR1, 2 and 3 sequences as set forth in SEQ ID NO:18, 19 and 20, and a VL region comprising CDR1, 2 and 3 sequences as set forth in SEQ ID NO:22, 23 and 24, d) a VH region comprising CDR1, 2 and 3 sequences as set forth in SEQ ID NO:26, 27 and 28, and a VL region comprising CDR1, 2 and 3 sequences as set forth in SEQ ID NO:30, 31 and 32, e) a VH region comprising CDR1, 2 and 3 sequences as set forth in SEQ ID NO:34, 35 and 36, and a VL region comprising CDR1, 2 and 3 sequences as set forth in SEQ ID NO:38, 39 and 40, f) a VH region comprising CDR1, 2 and 3 sequences as set forth in SEQ ID NO:42, 43 and 44, and a VL region comprising CDR1, 2 and 3 sequences as set forth in SEQ ID NO:14, 15 and 16, g) a VH region comprising CDR1, 2 and 3 sequences as set forth in SEQ ID NO: 46, 47 and 48, and a VL region comprising CDR1, 2 and 3 sequences as set forth in SEQ ID NO: 50, 51 and 52, h) a VH region comprising CDR1, 2 and 3 sequences as set forth in SEQ ID NO: 54, 55 and 56, and a VL region comprising CDR1, 2 and 3 sequences as set forth in SEQ ID NO: 58, 59 and 60, i) a VH region comprising CDR1, 2 and 3 sequences as set forth in SEQ ID NO: 62, 63 and 64, and a VL region comprising CDR1, 2 and 3 sequences as set forth in SEQ ID NO: 66, 67 and 68, or j) a VH region comprising CDR1, 2 and 3 sequences as set forth in SEQ ID NO: 70, 71 and 72, and a VL region comprising CDR1, 2 and 3 sequences as set forth in SEQ ID NO: 74, 75 and 76.