Patent ID: 9724435
Date: 2017-08-08
CPC Classifications: A61K,C07D

Claim:
1. A method of detecting increased S1R density at the site of nerve injury arising from neuropathic pain comprising S1R-PET imaging a tissue with an imaging agent to determine a non-invasive biomarker of nerve injury and inflammation wherein the imaging agent comprises at least one SR1 selective compound or radioligand selected from the general formula III′, or IV′ wherein R 1 is a radical of an optionally substituted piperazine, an optionally substituted tetrahydropyridine, an optionally substituted azepane or an optionally substituted tetrahydroisoquinoline in which the optional substituents are on the aromatic moiety or isoindoline-1,3-dione; R 2,4,5 are each independently any one or combinations of the following moieties, hydrogen, cyano, nitro, acyl, alkyl, amido, azido, isothiocyanate, isocyanate, optionally substituted anilino, halogens, ethers, sulfonamides, thioacyl, nitro, aromatic, heterocyclic, olefinic, acetylene, deuterium, or tritium; Z is O, “n” is 1 to 5 carbons in length; wherein the moiety bridging R 1 and N is a substituted alkylene; and wherein X is or C 1 -C 4 radiohaloalkyl; and stereoisomers, or pharmaceutically acceptable salts thereof.