Patent ID: 9657070
Date: 2017-05-23
CPC Classifications: A61K,C07K

Claim:
1. A recombinant Fel d 1 fusion product comprising a Fel d 1 chain 1 and a Fel d 1 chain 2, wherein the Fel d 1 chain 1 consists of (i) the amino acid sequence set forth in SEQ ID NO: 1, or (ii) the amino acid sequence set forth in SEQ ID NO: 1 having one or more amino acid substitutions selected from the group consisting of: Lys29Arg, Lys29Asn, and Val33Ser; and wherein Fel d 1 chain 2 consists of wherein the N-terminal amino acid of said Fel d 1 chain 1 is in direct fusion with the C-terminal amino acid of said Fel d 1 chain 2, and wherein said Fel d 1 chain 1 is covalently bonded with said Fel d 1 chain 2 by at least 1 disulfide bridge selected from the group consisting of: 3Cys(1)-73Cys(2), 44Cys(1)-48Cys(2) and 70(Cys(1)-7Cys(2), wherein said recombinant fusion product binds IgE from the serum of cat allergic subjects.