Patent ID: 9535074
Date: 2017-01-03
CPC Classifications: G01N

Claim:
1. A kit for detecting soluble human Programmed Cell Death 1 Ligand 1 (shPD-L1) in a liquid sample, wherein: (a) the kit comprises a capture binding molecule and a detector binding molecule; (b) the capture reagent is an isolated antibody or antigen binding fragment thereof that specifically binds shPD-L1 and comprises three light chain CDRs of SEQ ID NOs: 7, 8 and 9 and three heavy chain CDRs of SEQ ID NOs: 13, 14 and 15; and (c) the detector binding molecule is an isolated antibody or antigen binding fragment thereof that is capable of specifically binding to shPD-L1 molecules that are complexed with the capture binding molecule and which comprises: (a) three light chain CDRs of SEQ ID NOs: 19, 20 and 21 and three heavy chain CDRs of SEQ ID NOs: 25, 26 and 27; or (b) three light chain CDRs of SEQ ID NOs: 31, 32 and 33 and three heavy chain CDRs of SEQ ID NOs: 37, 38 and 39.