Patent ID: 9539222
Date: 2017-01-10
CPC Classifications: A61K

Claim:
1. A method of preventing, treating or inhibiting mycobacterial infections, the method comprising administering at least one of the compounds selected from the group consisting of: N,N-dimethyl imidodicarbonimidic diamide hydrochloride (Metformin); 3,5,4′-trihydroxy-trans-stilbene (Resveratrol); methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate (Bay K8644); 2,5-Dimethyl-4-[2-(phenylmethyl)benzoyl]-1H-pyrrole-3-carboxylic acid methyl ester (FPL 64176); 2′,5′-Dideoxyadenosine; 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-N,N-dimethyl-2,2-diphenylbutanamide hydrochloride (Loperamide); (5R,6S,8S)-Hexyl 6-hydroxy-5-methyl-13-oxo-6,7,8,13,14,15-hexahydro-5H-16-oxa-4b,8a,14-triaza-5,8-methanodibenzo[b,h]cycloocta[jkl]cyclopenta[e]-as-indacene-6-carboxylate (KT 5720); N-(dicyclopropylmethyl)-4,5-dihydro-1,3-oxazol-2-amine (Rilmenidine); 3-(2-methoxyethyl) 5-propan-2-yl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate (Nimodipine); (RS)-ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate (Nitrendipine); (2-{4-[(2-butyl-1-benzofuran-3-yl)carbonyl]-2,6-diiodophenoxy}ethyl)diethylamine (Amiodarone); and [(2R,3S,4R,5R)-5-(4-Carbamoyl-5-aminoimidazol-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate (AICAR), to a patient in need thereof, wherein the method further comprises administration of an anti-tuberculosis drug, wherein the anti-tuberculosis drug is selected from the group consisting of isoniazid, pyrazinamide, rifampicin, ethionamide, rifabutin, amikacin, ethambutol, PA824, bedaquiline, streptomycin, kanamycin, and fluoroquinolone antibiotic or a combination thereof.