Patent ID: 9534044
Date: 2017-01-03
CPC Classifications: A61P,C07K,G01N

Claim:
1. An antibody or fragment thereof having high binding affinity for α-synuclein oligomers, high binding affinity to α-synuclein fibrils, and low binding affinity for α-synuclein monomers wherein the antibody or fragment thereof comprises a VH chain wherein the CDR1 region has the amino acid sequence of SEQ ID NO:16, SEQ ID NO:28, or SEQ ID NO:40; wherein the CDR2 region has the amino acid sequence of SEQ ID NO:17, SEQ ID NO:29, or SEQ ID NO:41; and wherein the CDR3 region has the amino acid sequence of SEQ ID NO:18, SEQ ID NO:30, or SEQ ID NO:42; and/or wherein the antibody or fragment thereof comprises a VL chain wherein the CDR1 region has the amino acid sequence SEQ ID NO:22, SEQ ID NO:34, or SEQ ID NO:46; wherein the CDR2 has the amino acid sequence of SEQ ID NO:23, SEQ ID NO:35, or SEQ ID NO:47; and wherein the CDR3 region has the amino acid sequence of SEQ ID NO:24, SEQ ID NO:36, or SEQ ID NO:48.