Patent ID: 9663763
Date: 2017-05-30
CPC Classifications: A61K,A61P,C12N

Claim:
1. A method of treating cancer in a subject by administering a therapeutically effective amount of an isolated modified primary human T cell to a subject in need thereof, said therapeutically effective amount being one sufficient to kill cancer cells in the treated subject, wherein said isolated modified primary human T cell is derived from a primary human T cell isolated from a human donor, and (i) is modified to functionally impair or to reduce expression of the endogenous T cell receptor (TCR), and (ii) is further modified to express at least one functional exogenous non-TCR that comprises a chimeric receptor which recognizes a ligand expressed on the surface of cancer cells in the treated subject, said chimeric receptor comprising a ligand binding domain attached to a signaling domain, wherein the isolated primary human T cell modified as in (i) and (ii) elicits no or a reduced graft-versus-host disease (GVHD) response in a histoincompatible human recipient as compared to the GVHD response elicited by a primary human T cell isolated from the same human donor that is only modified as in (ii), and further wherein the isolated modified primary human T cell recognizes and kills cancer cells.