Patent ID: 9637517
Date: 2017-05-02
CPC Classifications: A61P,C07K,Y02P

Claim:
1. A method for the preparation of exenatide comprising: (a) obtaining a serine-resin by a first coupling between serine and resin; (b) obtaining a peptide-resin of SEQ ID NO: 1 by a secondary coupling of said serine-resin sequentially with amino acids; and (c) obtaining a peptide-resin of SEQ ID NO: 2 by a third coupling between the protective group-containing histidine or a salt thereof with said peptide-resin of SEQ ID No. 1, and exenatide is finally obtained after cleavage and purification wherein the protective group-containing histidine or a salt thereof in step (c) has the structure as shown in formula IV:  wherein step (c) comprises obtaining exenatide-resin in a solvent in the presence of a coupling agent and an organic base, wherein the coupling agent is HATU and HOAt.