Patent ID: 9693841
Date: 2017-07-04
CPC Classifications: A61B,A61C,A61L,A61M,B05D

Claim:
1. A method of treating the surface of a surgical closure device with a biomolecule comprising the steps of: a) providing a polyolefin substrate forming a medical device; b) cleaning the polyolefin substrate; c) exposing the polyolefin substrate to a reactive gas containing siloxane functional groups and plasma energy to yield a plasma-deposited polysiloxane surface on the surface of the polyolefin substrate, then exposing the polyolefin substrate to a reactive gas containing acrylic acid and to plasma energy to yield a plasma-deposited polyacrylic acid coating on the polyolefin substrate; and d) attaching a biomolecule to the polyolefin substrate following formation of the plasma-deposited polyacrylic acid coating on the polyolefin substrate, and wherein the biomolecule is at least one of an antibacterial agent, antimicrobial agent, anticoagulant, heparin, antithrombotic agent, platelet agent, anti-inflammatory, enzyme, catalyst, hormone, growth factor, drug, vitamin, antibody, antigen, protein, nucleic acid, dye, a DNA segment, an RNA segment, protein, and peptide.