Patent ID: 9676814
Date: 2017-06-13
CPC Classifications: A61P,C07B,C07J

Claim:
1. A process for the synthesis of a compound of formula (I) wherein R in formula (I) is a dimethylamino or an acetyl group, the process comprises wherein R in formula (II) is a dimethylamino or a 2-methyl-1,3-dioxolan-2-yl group, with chloromethyl silane in the presence of imidazole in a halogenated solvent, tetrahydrofuran or toluene, at room temperature; with 2-15 mol equivalent of methyllithium in the presence of tetraalkyl ethylenediamine in an ether or a formaldehyde acetal type solvent, or in a mixture thereof, at a temperature of between (−78° C.) and (−20° C.), with acetic anhydride in a halogenated solvent, in the presence of 70% perchloric acid, at a temperature of between (−78° C.) and 0° C., and