Patent ID: 9586899
Date: 2017-03-07
CPC Classifications: A61P,C07C,C07D

Claim:
1. A method for stereoselectively making an aminocyclohexyl ether of the following formula (79), formula (80) or formula (81): wherein R or R which method comprises: (a) reacting a compound of formula (75): where R wherein each Lg is independently a leaving group and each R or reacting a compound of formula (75) with a compound of formula (88), a compound of formula (89) or a compound of formula (90): wherein each Lg is independently a leaving group and each R or reacting a compound of formula (75) with a compound of formula (94), a compound of formula (95) or a compound of formula (96): wherein each R and (b) reducing the compound of formula (85), the compound of formula (91) or the compound of formula (97) formed in step (a) under suitable conditions to form a compound of formula (79) as set forth above; or reducing the compound of formula (86), the compound of formula (92) or the compound of formula (98) formed in step (a) under suitable conditions to form a compound of formula (80) as set forth above; or reducing the compound of formula (87), the compound of formula (93) or the compound of formula (99) formed in step (a) under suitable conditions to form a compound of formula (81) as set forth above.