Patent ID: 9610248
Date: 2017-04-04
CPC Classifications: A61K,A61P,C12N

Claim:
1. An immunogenic composition comprising an influenza virus hemagglutinin antigen from at least one of influenza A H1N1 and influenza A H3N2 strain and lipid vesicles, wherein the lipid vesicles comprise lipids that are present in the composition in an amount that achieves a lipid:antigen weight ratio within a range of about 50:1 to about 400:1 and the lipids include a non-ionic surfactant comprising 1-monopalmitoyl glycerol, wherein the composition is more stable when stored for 6 months at 40° C. than a reference composition that lacks the lipid vesicles, and (i) wherein the composition comprises one or more inactivated influenza viruses that include the influenza virus hemagglutinin antigen, (ii) wherein the composition comprises one or more attenuated influenza viruses that include the influenza virus hemagglutinin antigen, (iii) wherein the influenza virus hemagglutinin antigen is present in the composition as a split virus antigen, or (iv) wherein the influenza virus hemagglutinin antigen is present in the composition as a purified or recombinant subunit antigen.