Patent ID: 9731011
Date: 2017-08-15
CPC Classifications: A61K,A61P,C07K

Claim:
1. A method for treating a tumor in a subject, comprising administering to the subject: (a) a first composition comprising intact bacterial minicells, each of which encompasses an anti-neoplastic agent and carries a ligand on the surface of the intact bacterial minicells, wherein (i) the ligand has specificity to a non-phagocytic mammalian cell surface receptor, (ii) the antineoplastic agent is selected from the group consisting of a radionuclide, a chemotherapy drug, a functional nucleic acid selected from the group consisting of siRNA, miRNA, shRNA, lincRNA, antisense RNA, and ribozyme, and a polynucleotide from which a functional nucleic acid selected from the group consisting of siRNA, miRNA, shRNA, lincRNA, antisense RNA, and ribozyme is transcribed, and (b) a second composition comprising interferon-gamma (IFN-gamma) or an agent that increases the expression of IFN-gamma in the subject, wherein the agent that increases the expression of IFN-gamma is a viral vaccine that induces IFN-gamma expression or a polynucleotide encoding IFN-gamma, wherein the first and second compositions are administered concurrently or sequentially.