Patent ID: 9629898
Date: 2017-04-25
CPC Classifications: A61K,A61P,C07K,Y02A,Y10S

Claim:
1. A method for reducing liver damage or liver inflammation caused by viral hepatitis in a subject in need thereof comprising administering to the subject an effective amount of an interleukin 22 (IL-22) dimer, wherein said IL-22 dimer is shown as formula (I): wherein M1 is a first human IL-22 monomer; M2 is a second human IL-22 monomer; and L is a linker connecting said first human IL-22 monomer and said second human IL-22 monomer and disposed therebetween; wherein said IL-22 dimer retains the biological activity of IL-22 and has a serum half-life of at least twice of the half-life of either said first or said second human IL-22 monomer.