Patent ID: 9617544
Date: 2017-04-11
CPC Classifications: A61K,C12N

Claim:
1. A nanoparticle comprising: a) siRNA; b) oley trimethly chitosan (OTMC); c) poly(γ-(4-(((2-(piperidin-1-yl)ethyl)amino)methyl)benzyl- d) oleyl-PEG-mannose(OPM); e) oleyl-PEG-cysteamine(OPC); and f) sodium tripolyphosphate(TPP); wherein the OTMC/TPP components of the nanoparticle are present in a ratio of about 8:1(w/w), the OTMC/OPM/OPC components of the nanoparticle are present in a ratio of about 1:1:1(w/w); and the nanoparticle has a diameter of about 100 nm to about 140 nm.