Patent ID: 9737589
Date: 2017-08-22
CPC Classifications: A61K,A61P

Claim:
1. A method for reducing a tumor-initiating cell pool comprising a tumor stem cell of a glioblastoma multiforme brain tumor in a subject, the method comprising administering to the subject a pharmaceutical composition comprising a therapeutic amount of a Leukemia Inhibitory Factor (LIF) preparation comprising human LIF, the therapeutic amount of the LIF preparation being effective to reduce the tumor-initiating pool of the tumor stem cell by irreversibly reducing (1) size of the tumor stem cells; (2) clonogenic index of the tumor stem cells; (3) growth rate of the tumor stem cells; or (4) a combination thereof, wherein the administering is to an unresected tumor, to a resection cavity following tumor resection, or first intratumorally and then to the resection cavity.