Patent ID: 9676862
Date: 2017-06-13
CPC Classifications: A61K,A61P,C07K

Claim:
1. An antibody or an antigen-binding fragment thereof with multivalent binding specificity for CD40, wherein the antibody or antigen-binding fragment thereof comprises: (a) a light chain variably domain (V L ) comprising CDR1, CDR2 and CDR3 of the following sequences, respectively: (i) SEQ ID NO:4 and SEQ ID NO:10 and SEQ ID NO:12; or (ii) SEQ ID NO:5 and SEQ ID NO:10 and SEQ ID NO:13; or (iii) SEQ ID NO:7 and SEQ ID NO:11 and SEQ ID NO:15; or (iv) SEQ ID NO:8 and SEQ ID NO:10 and SEQ ID NO:16; or (v) SEQ ID NO:9 and SEQ ID NO:10 and SEQ ID NO:17; or (vi) SEQ ID NO:9 and SEQ ID NO:10 and SEQ ID NO:12; or (vii) SEQ ID NO:9 and SEQ ID NO:10 and SEQ ID NO:18; and (b) a heavy chain variably domain (V H ) comprising CDR1, CDR2 and CDR3 of SEQ ID NO:28, SEQ ID NO:29, and SEQ ID NO:30, respectively.