Patent ID: 9573983
Date: 2017-02-21
CPC Classifications: C07K

Claim:
1. A compound comprising: a modified I-domain peptide comprising SEQ ID NO: 1 that is capable of binding a D1 domain of ICAM-1, the modified I-domain peptide having two or more modified lysine residues; and two or more signal 1 moieities conjugated to the modified lysine residues of the I-domain peptide, wherein the two or more signal 1 moieities are the same or different and wherein the two or more signal 1 moieties are chosen from epitopes of proteolipid protein (PLP), myelin basic protein (MBP), myelin oligodendrocyte glycoprotein (MOG), and a combination thereof, wherein the epitopes of PLP, MBP, and MOG are chosen from peptide sequences selected from the group consisting of: SEQ ID NOs: 2-28, and wherein any signal 1 moiety comprising an epitope of MOG also comprises a poly-ethylene glycol (PEG) spacer.