Patent ID: 9617288
Date: 2017-04-11
CPC Classifications: C07B,C07F

Claim:
1. A method for preparing a racemic or optically active D or L-α-glycerophosphorylcholine represented by the following Formula 1, the method comprising subjecting a choline phosphate represented by the following Formula 2 or a salt thereof, and an (S) or (R)-3-halo-1,2-propanedion represented by the following Formula 3 to a substitution reaction in a medium at a temperature of 60° C. to 100° C., thereby preparing the racemic or optically active D or L-α-glycerophosphorylcholine via a one-pot reaction without an (R)-glycidol intermediate production process: wherein * is a chiral center; Formula 1 represents a racemic or optically active D or L-α-glycerophosphorylcholine isomer; Formula 2 represents choline phosphate or a salt thereof; and X in Formula 3 denotes fluorine, chlorine, bromine or iodine.