Patent ID: 9598419
Date: 2017-03-21
CPC Classifications: A61K,A61P,C07D

Claim:
1. A compound of Formula I: or a stereoisomer, tautomer, pharmaceutically acceptable salt, or solvate thereof, wherein: the dashed line represents an optional double-bond; X is N, one of Y and Z is N and the other of Y and Z is CR X is CR X 1 is O and X 2 is CH, CR 10 , or N; or X X X X X X W is O or S; R R R R R is selected from the group consisting of a phenyl ring, a 5-membered heteroaryl ring containing at least one O, N or S atom, or a 6-membered heteroaryl ring, containing at least one nitrogen atom; R R D is a linker, which is selected from a single bond, —O—, —S—, C 1 -C 4 alkylene substituted by 0 to 4 groups independently selected from halo or OH, C 1 -C 4 alkyleneoxy, C 1 -C 4 alkylenethio, C 1 -C 4 alkyleneoxy-C 1 -C 4 -alkylene, C 1 -C 4 -alkylenethio-C 1 -C 4 -alkylene, —S—C 1 -C 4 -alkylene, —O—C 1 -C 4 -alkylene, —NHC(═O)—, —C(═O)NH— and C 2 -C 6 alkenylene, B is selected from the group consisting of a C R R R alternatively, R R R R or R n, at each occurrence, is selected from 0, 1, 2, 3, 4 or 5; and p, each occurrence, is selected from 0, 1 and 2.