Patent ID: 9638702
Date: 2017-05-02
CPC Classifications: C07K,G01N

Claim:
1. A method for detecting misfolded Aβ peptide in a sample comprising: (a) contacting a liquid sample that comprises a liquid biological sample obtained from a subject and does not contain homogenized tissue with a peptide probe comprising an amino acid sequence corresponding to a β-sheet forming region of said Aβ peptide, wherein the peptide probe exhibits a random coil or alpha-helix conformation in solution and undergoes a transition to a β-sheet conformation upon interaction with Aβ peptide exhibiting a β-sheet conformation, wherein the amino acid sequence of the peptide probe comprises a sequence that is at least 70% identical to any one of SEQ ID NOs: 4-7, (b) permitting the peptide probe to interact with any misfolded Aβ peptide present in the sample; and (c) detecting any interaction between the peptide probe and any misfolded Aβ peptide present in the sample.