Patent ID: 9637524
Date: 2017-05-02
CPC Classifications: A61K,A61P,C07K,C12N

Claim:
1. A composition comprising: an hepatitis E virus (HEV) capsid protein comprising residues 112-608 of HEV ORF 2 protein of SEQ ID NO: 1(genotype 2), 4(genotype 1), 5(genotype 3), or 6(genotype 4), a first heterologous peptide, and a second heterologous peptide, wherein the first heterologous peptide is inserted at a position of the HEV ORF 2 protein that is immediately after residue Tyr485, and the second heterologous peptide is inserted after residue 608 of the HEV ORF2 protein; and a heterologous nucleic acid encapsulated in a chimeric virus-like particle (VLP) formed by the HEV capsid protein.