Patent ID: 9730884
Date: 2017-08-15
CPC Classifications: A61K,A61P

Claim:
1. A pharmaceutical composition formulated for oral administration comprising a suspension of a crystalline solid, biologically active agent in a non-aqueous liquid carrier, wherein the weight ratio of said active agent to said non-aqueous liquid carrier is between about 50:1 and about 1:10, wherein the pharmaceutical composition is a solid-in-oil suspension that is substantially free of water and wherein the non-aqueous carrier is an oil wherein: (a) the carrier comprises at least 10 wt % of free monocarboxylic acid having at least 8 carbons, wherein the monocarboxylic acid is liquid at room temperature; (b) the carrier comprises from about 0.0001 wt. % to about 5 wt. % of zwitterionic phospholipids; and (c) the pharmaceutical composition releases a lesser amount of active agent at a pH of <3 than at pH >3, wherein the composition is formulated in the absence of a solvent.