Patent ID: 9616085
Date: 2017-04-11
CPC Classifications: A61K

Claim:
1. An siRNA hydrogel having a three dimensional network structure comprising pluralities of sense conjugate 1 and antisense conjugate 1 sense conjugate 1 and antisense conjugate 2 or antisense conjugate 1 and sense conjugate 2 wherein (a) X is a sense strand of siRNA, (b) Y is an antisense strand of siRNA, is tris-(2-maleimidoethyl)-amine (TMEA), (d) “•” is a bond formed between X or Y and is a linkage mediated by dithio-bis-maleimidoethane(DTME) or 1,8-bis-maleimidodiethyleneglycol BM(PEG) 2 between the Ys in antisense conjugate 2 or the Xs in sense conjugate 2, (f) • and are formed through the reaction of a functional group introduced to an end of X and Y prior to formation of • and wherein each of the functional groups may be the same or different, and (g) the three dimensional network structure comprises crosslinking between the plurality of sense and antisense conjugates through complementary hybridization between X and Y in adjacent sense and antisense conjugates.