Patent ID: 9737491
Date: 2017-08-22
CPC Classifications: A61K

Claim:
1. A method of delivering a pharmaceutical agent across a mucosal barrier, the method comprising: delivering to the mucosal barrier a composition comprising a plurality of coated particles, wherein the coated particles comprise: wherein the surface-altering agent comprises a triblock copolymer comprising a hydrophilic block-hydrophobic block-hydrophilic block configuration, wherein the hydrophobic block has a molecular weight of at least 2 kDa, and the hydrophilic blocks constitute at least 15 wt % of the triblock copolymer, wherein the hydrophobic block associates with the surface of the core particle and renders the coated particle hydrophilic, and wherein the coated particles have a relative velocity of greater than 0.5 in mucus and pass through the mucosal barrier.