Patent ID: 9624544
Date: 2017-04-18
CPC Classifications: C12Q

Claim:
1. A nucleic acid encoding a fragment of SEQ ID NO: 1, or the complementary sequence thereof, with the exception that there is a histidine at amino acid position 6 of SEQ ID NO: 1 and a cysteine at amino acid position 53 of SEQ ID NO: 1, wherein said nucleic acid specifically binds to a TRPV4 nucleic acid encoding at least one mutation selected from R316C and R269H and said nucleic acid does not bind to a TRPV4 nucleic acid encoding an arginine at position 269 or an arginine at position 316, wherein the nucleic acid comprises a T at a position corresponding to nucleotide 946 of exon 6 of TRPV4 and/or an A at a position corresponding to nucleotide 808 of exon 5 of TRPV4, and wherein the nucleic acid is detectably labeled with a fluorescent label.