Patent ID: 9603831
Date: 2017-03-28
CPC Classifications: A01N,A61K,A61M,A61P,G01N

Claim:
1. A method of treating acute kidney injury or a method of treating acute kidney injury in a patient undergoing kidney dialysis or surgery that results in ischaemia-reperfusion of the whole or part of the kidney, kidney transplantation surgery, kidney and pancreas transplantation surgery, or coronary artery bypass surgery comprising administering a compound according to Formula I or a pharmaceutically acceptable salt or ester thereof, or a pharmaceutical composition comprising the compound according to Formula I or a pharmaceutically acceptable salt or ester thereof wherein the pharmaceutical composition further comprises a pharmaceutically acceptable excipient, to a patient in need thereof, wherein: R R a) the compound or pharmaceutical composition is administered to the patient at least 12 hours after ischaemia-reperfusion of the whole or part of the kidney or at least 12 hours after kidney transplantation surgery, kidney and pancreas transplantation surgery, or coronary artery bypass surgery; b) the compound or pharmaceutical composition is administered to the patient after diagnosis of acute kidney injury or after diagnosis of a risk of acute kidney injury; c) the method further comprises measuring serum creatinine levels after surgery and administering the compound or pharmaceutical composition only if acute kidney injury is diagnosed or if the patient is deemed at risk of developing acute kidney injury; or d) the patient is undergoing kidney transplantation, wherein the composition comprising the compound of Formula I, or pharmaceutically acceptable salt or ester thereof, is a reperfusion solution, wherein the reperfusion solution further comprises one or more volume expanders, and wherein the method further comprises bathing the donor kidney in or reperfusing the donor kidney with the reperfusion solution.