Patent ID: 9724411
Date: 2017-08-08
CPC Classifications: A61K,A61P,C07K

Claim:
1. A method for treating hypercholesterolemia in a patient, the method comprising administering to the patient a first dose of a pharmaceutical composition comprising an antibody or antigen-binding fragment thereof that specifically binds hPCSK9, wherein the amount of the antibody in the first dose is 75 mg (“the 75 mg dose”); and administering to the patient a second dose of a pharmaceutical composition comprising the antibody or antigen-binding fragment thereof that specifically binds hPCSK9, wherein the amount of antibody in the second dose is 150 mg (“the 150 mg dose”); wherein the 150 mg dose is administered to the patient two weeks after the 75 mg dose; wherein the antibody or antigen-binding fragment that specifically binds hPCSK9 comprises the heavy and light chain CDRs of a HCVR/LCVR amino acid sequence pair selected from the group consisting of SEQ ID NOs:90/92 and 218/226.