Patent ID: 9650368
Date: 2017-05-16
CPC Classifications: C07D,C07F

Claim:
1. A process to prepare a compound of Formula (II): wherein Q is S or O, X is Cl or Br, and R which process comprises: converting boronic acid A1 to carbaldehyde B1 through activation of the boronic acid with an activating reactant A2; converting carbaldehyde B1 to acetal C1 under acid catalysis with a suitable source of orthoformate; converting acetal C1 to nitrile D1 through catalyzed cyanation with a metal catalyst and a cyanide source; hydrolyzing D1 with a suitable acid to give carboxylic acid E1; converting carboxylic acid E1 to amide F1 with a suitable base, a suitable coupling reagent, and a source amine; converting amide F1 to a compound of Formula (II) with an anionic coupling reagent having structure H1, optionally converting the compound of Formula (II) to a salt.