Patent ID: 9714288
Date: 2017-07-25
CPC Classifications: A61K,C07K,C12N

Claim:
1. A compound comprising one or more modified oligonucleotides and an anti-CD22 antibody, wherein the one or more modified oligonucleotides comprise: 16 linked nucleosides having a nucleobase sequence of the sequence recited in SEQ ID NOs: 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, or 17; a gap segment consisting of ten linked deoxynucleosides; a 5′ wing segment consisting of three linked nucleosides; and a 3′ wing segment consisting of three linked nucleosides; wherein the gap segment is positioned between the 5′ wing segment and the 3′ wing segment; wherein each nucleoside of the 5′ wing segment comprises a (S)-cEt sugar modification; wherein each nucleoside of the 3