Patent ID: 9642926
Date: 2017-05-09
CPC Classifications: A61K,A61P,B82Y

Claim:
1. A complex of sequentially deliverable pharmaceutical reagents useful for detecting a target exposed in a lumen through imaging, wherein the complex is formed in vivo, the complex comprising: a target exposed on a surface of a lumen within a body of a subject; at least one targeting vesicle bound to the target; a plurality of amplification vesicles, wherein at least two amplification vesicles are directly bound to a single targeting vesicle; a plurality of imaging vesicles; wherein each of the plurality of imaging vesicles is bound to an amplification vesicle, and wherein at least the imaging vesicles are detectable by an imaging modality, thus allowing detection of the complex bound to the target; and wherein the complex is formed in the lumen within the subject's body and bound to the surface of the lumen, and the target exposed in the lumen is detected via the imaging modality present in the complex.