Patent ID: 9738707
Date: 2017-08-22
CPC Classifications: C07K

Claim:
1. A binding molecule comprising: (i) a binding moiety, wherein the binding moiety comprises an immunoglobulin heavy chain variable domain (VH) and an immunoglobulin light chain variable domain (VL), (ii) a first Fc polypeptide chain comprising a first CH2 domain operably linked to the N-terminus of a CL moiety (CH2-CL), and (iii) a second Fc polypeptide chain comprising a second CH2 domain operably linked to the N-terminus of a CH1 moiety (CH2-CH1), wherein the binding moiety is linked to one or both of the first and second Fc polypeptide chains, wherein said first and second Fc polypeptide chains form a heterodimeric Fc region via CL moiety:CH1 moiety heterodimerization, wherein the CL moiety comprises an amino acid sequence selected from the group consisting of amino acids: 126-233 of SEQ ID NO:28, 126-233 of SEQ ID NO:29, 126-233 of SEQ ID NO:30, 126-235 of SEQ ID NO:31, 126-235 of SEQ ID NO:32, 126-235 of SEQ ID NO:33, 126-237 of SEQ ID NO:34, 126-237 of SEQ ID NO:35, 126-237 of SEQ ID NO:36, and 153-260 of SEQ ID NO:46, and wherein the CH1 moiety comprises an amino acid sequence selected from the group consisting of amino acids: 126-228 of SEQ ID NO:37, 126-224 of SEQ ID NO:38, 126-224 of SEQ ID NO:39, 126-224 of SEQ ID NO:40, 126-225 of SEQ ID NO:41, 126-226 of SEQ ID NO:42, 126-226 of SEQ ID NO:43, 126-226 of SEQ ID NO:44, 126-227 of SEQ ID NO:45, 406-504 of SEQ ID NO:47, 406-504 of SEQ ID NO:48, and 406-504 of SEQ ID NO:49.