Patent ID: 9738643
Date: 2017-08-22
CPC Classifications: C07D,G01N

Claim:
1. A compound of formula (I): wherein: A is a heat shock protein 90 binding component; X X L is a divalent linker of the following formula: B is selected from the group consisting of a detection moiety, an anti-cancer agent, and a heat shock protein 90 binding component; and R is selected from the group consisting of —H and a detection moiety; wherein each heat shock protein 90 binding component independently has the following formula (II): wherein: R Y is CR R R R R X is N; and represents the point of attachment in formula (I); wherein each detection moiety independently comprises a fluorophore or a radioactive compound; wherein the fluorophore is a fluorescein, a rhodamine, a coumarin, a cyanine, or a boron-dipyrromethene; wherein the radioactive compound is a radioisotope; and wherein the anti-cancer agent is an alkylating agent, an anti-epidermal growth factor receptor antibody, an anti-Her-2 antibody, an antimetabolite, a vinca alkaloid, an anthracycline, a platinum-based agent, a topoisomerase inhibitor, a taxane, an anti-cancer antibiotic, an immune cell antibody, an interferon, an interleukin, a heat shock protein 90 inhibitor, an anti-androgen, an anti-estrogen, an antihypercalcemia agent, an apoptosis inducer, an aurora kinase inhibitor, a Bruton's tyrosine kinase inhibitor, a calcineurin inhibitor, a Ca