Patent ID: 9745303
Date: 2017-08-29
CPC Classifications: A61K,C07D,C07K

Claim:
1. A method of synthesizing a compound of formula III:, from a compound of formula VI: which proceeds via a compound of formula VIIa or VI lb: wherein: R where A is a phenyl or C R L wherein n is 0 to 3; L  where X is such that L Prot is selected from Fmoc (fluorenylmethyloxycarbonyl), Teoc (2-(trimethylsilyl)ethoxycarbonyl) and Boc (t-butoxycarbonyl); R phenyl, which phenyl is optionally substituted by a group selected from halo, methyl, methoxy; pyridyl; and thiophenyl; and R R R″ is a C Y and Y′ are selected from O, S, and NH; SEM is 2-((trimethylsilyl)ethoxy)methyl; OTf is CF C C C C C R wherein the R wherein the R  is  or otherwise the derivative is R