Patent ID: 9569584
Date: 2017-02-14
CPC Classifications: G16B

Claim:
1. A computer program product for constructing a gene interaction network, the computer program product comprising a computer readable storage medium having program code embodied therewith, the program code executable by a processor to: for each pair of genes in a first set of gene expression data, compute a first gene interaction measure between a pair of genes, based upon the gene expression data, the computation comprising program code to: cluster genes from the first set based on the expression data, the clustering comprising program code to: generate a multi-dimensional image stack via RNAi screening for each pair of genes in a second set having image data depicting groups of cells or intra-cellular structures associated with the second set of genes; activate a construction manager in a remote server, the activated construction manager programmed to: construct an initial graph based on the gene interaction and the gene relationship measures by combining the first set of gene expression data with the image data of the second set, each node in the graph associated with one of the genes belonging to one of the first and second sets; and draw edges between nodes, the edges based on membership of gene clusters or morphological distance for a corresponding gene knockdown image stack; construct a final graph by expanding connectivity among the nodes in the graph using network propagation, the expanded connectivity forming the gene interaction network; and output the formed gene interaction network to the computer readable storage medium.