Patent ID: 9717678
Date: 2017-08-01
CPC Classifications: A61K,A61P

Claim:
1. A method of making a microemulsion delivery system for oral administration to a patient of Fenobam, its hydrates, or salts, consisting of: mixing (a) about 1% to 50% w/w/ of Fenobam, its hydrates, or salts; (b) about 1% to 97% w/w of one or more co-solvents, wherein the one or more co-solvents are present in sufficient quantity to completely dissolve Fenobam, its hydrates, or salts based on solubility data obtained, and wherein said one or more co-solvents are selected from the group consisting of dimethylacetamide, dimethylsulfoxide, ethanol, glycerin, n-methyl-2-pyrrolidone, PEG 300, PEG 400, poloxamer 407, and propylene glycol; (c) about 1% to 97% w/w of one or more surfactants, wherein the one or more surfactants are selected from the group consisting of polyoxyl 35 castor oil, polyoxyl 40 hydrogenated castor oil, polyoxyl 60 hydrogenated castor oil, polysorbate 20, polysorbate, d-α-tocopherol polyethylene glycol 1000 succinate, sorbitan monooleate, PEG 300 caprylic/capric glycerides, PEG 400 caprylic/capric glycerides, PEG 300 oleic glycerides, PEG 300 linoleic glycerides, polyoxyl 8 stearate (PEG 400 monostearate), and polyoxyl 40 stearate (PEG 1750 monostearate); and (d) about 1% to 50% w/w of one or more precipitation inhibitors to form a microemulsion formulation such that sufficient quantity of co-solvents are present as inactive ingredients to dissolve Fenobam, its hydrates, or salts; and filling into a hard gelatin capsule.