Patent ID: 9556265
Date: 2017-01-31
CPC Classifications: A61P,C07K

Claim:
1. An isolated immunobinder comprising one of the following solubility enhancing motifs in the heavy chain amino acid positions 12, 103 and 144 (AHo numbering): (a) Serine (S) at heavy chain amino acid position 12; Serine (S) at heavy chain amino acid position 103; and Threonine (T) at heavy chain amino acid position 144; or (b) Serine (S) at heavy chain amino acid position 12; Threonine (T) at heavy chain amino acid position 103; and Serine (S) at heavy chain amino acid position 144; or (c) Serine (S) at heavy chain amino acid position 12; Threonine (T) at heavy chain amino acid position 103; and Threonine (T) at heavy chain amino acid position 144, wherein the presence of said motif increases the overall solubility of the native immunobinder.