Patent ID: 9555139
Date: 2017-01-31
CPC Classifications: A61K,A61P,C07K

Claim:
1. A drug delivery conjugate B-L-D of the formula wherein: n is an integer from 1 to 3; V is H, OR Z is alkyl or C(O)R T is H or OR S1 and U are each independently selected from the group consisting of H, halo, nitro, cyano, alkyl, haloalkyl, alkoxy, and haloalkoxy; and X B is of the formula wherein *** represents the point of attachment to the rest of the conjugate; L is a bivalent linker comprising at least one releasable linker that is not a disulfide releasable linker and at least one spacer linker of the formula wherein * represents the point of attachment of one or more additional spacer linkers, one or more releasable linkers, D, or B; and D is a tubulysin of the formula wherein ** represents the point of attachment of D to L; or a pharmaceutically acceptable salt thereof.