Patent ID: 9718825
Date: 2017-08-01
CPC Classifications: A61K,A61P,C07D

Claim:
1. A compound of formula I, a stereoisomeric form thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein Ar is selected from the group consisting of phenyl and a 5-membered or 6-membered monocyclic, aromatic, heterocyclic group which comprises 1, 2 or 3 identical or different ring heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur, and is bonded via a ring carbon atom, which all are unsubstituted or substituted by one or more identical or different substituents R5; n is selected from the group consisting of 0, 1 and 2; X is selected from the group consisting of N and CH; Z is selected from the group consisting of a direct bond, O, S and N(R10); R1 is selected from the group consisting of H, —N(R11)-R12, —N(R13)-C(O)-R14, —N(R13)-S(O) R2 is selected from the group consisting of halogen, (C R3 is selected from the group consisting of H, (C R5 is selected from the group consisting of halogen, (C or two groups R5 attached to adjacent ring carbon atoms of Ar, together with the carbon atoms to which they are attached, form a 5-membered to 8-membered monocyclic, unsaturated ring which comprises 0, 1 or 2 identical or different ring heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur, and which is unsubstituted or substituted by one or more identical or different substituents R8; R6 and R7 are independently selected from the group consisting of H and (C R8 is selected from the group consisting of halogen, (C R10 is selected from the group consisting of H and (C R11 and R12 are independently selected from the group consisting of H, (C or R11 and R12, together with the nitrogen atom to which they are attached, form a 4-membered to 7-membered monocyclic, saturated, heterocyclic group which, in addition to the nitrogen atom to which R11 and R12 are attached, comprises 0 or 1 further ring heteroatom selected from the group consisting of nitrogen, oxygen and sulfur, and which is unsubstituted or substituted by one or more identical or different substituents selected from the group consisting of fluorine and (C R13 is selected from the group consisting of H, (C R14 and R16 are independently selected from the group consisting of (C R15 is selected from the group consisting of (C R17 is selected from the group consisting of H and (C R30 is a 3-membered to 12-membered monocyclic or bicyclic, saturated or partially unsaturated cyclic group which comprises 0 ring heteroatoms, which is unsubstituted or substituted by one or more identical or different substituents R32, or R30 is a 3-membered to 12-membered monocyclic or bicyclic, saturated, partially unsaturated or aromatic, cyclic group which comprises 1, 2 or 3 identical or different ring heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur, which is unsubstituted or substituted by one or more identical or different substituents R32; R31 is selected from the group consisting of halogen, —OH, —O—(C R32 is selected from the group consisting of halogen, (C R33, R34, R35, R36, R37, R38, R39, R40, R41, R42 and R43 are independently selected from the group consisting of H and (C R50 is selected from the group consisting of halogen, (C Het1 is a 4-membered to 7-membered monocyclic, saturated, heterocyclic group which comprises 1 or 2 identical or different ring heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur, and is bonded via a ring carbon atom, and which is unsubstituted or substituted by one or more identical or different substituents selected from the group consisting of fluorine and (C Het2 is a 4-membered to 7-membered monocyclic, saturated, partially unsaturated or aromatic, heterocyclic group which comprises 1 or 2 identical or different ring heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur, and is bonded via a ring carbon atom; and Het3 is a 5-membered or 6-membered monocyclic, aromatic, heterocyclic group which comprises 1, 2 or 3 identical or different ring heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur, and is bonded via a ring carbon atom; wherein all cycloalkyl groups, independently of any other substituents which can be present on a cycloalkyl group, can be substituted by one or more identical or different substituents selected from the group consisting of fluorine and (C wherein all alkyl groups, independently of any other substituents which can be present on an alkyl group, can be substituted by one or more fluorine substituents.