Patent ID: 9610356
Date: 2017-04-04
CPC Classifications: A61K,A61P,C07K,G01N

Claim:
1. A method of treating or ameliorating iron deficiency, comprising administering to a subject in need thereof a therapeutically effective amount of a pharmaceutical composition comprising a lipocalin mutein, or a fragment thereof having binding affinity to hepcidin, wherein the lipocalin mutein has the same amino acids as the mutein set forth in SEQ ID NO: 1 at two or more positions corresponding to positions 36, 40, 41, 49, 52, 68, 70, 72, 73, 77, 79, 81, 96, 100, 103, 106, 125, 127, 132, and 134 of the linear polypeptide sequence of the mature hNGAL, wherein the lipocalin mutein or fragment is capable of increasing the bioavailability of iron in the subject, wherein said fragment lacks at least one of the N-terminal and/or C-terminal amino acids compared to said lipocalin mutein.