Patent ID: 9695149
Date: 2017-07-04
CPC Classifications: A61K,A61P,C07D

Claim:
1. A compound of Formula (I) wherein: X X X R X R R X X X X X R provided that the second eluting isomer of racemic cis-2-{1-(4-Cyanobenzyl)-6-[(5-methylpyridin-2-yl)methoxy]-1H-benzimidazol-2-yl}cyclohexanecarboxylic acid when purified by chiral SFC on (CHIRALCEL OJ-H 5 μm 250×20 mm) mobile phase (65% CO 2 , 35% EtOH), the second eluting isomer of racemic cis-3-{1-(4-Bromo-2-fluorobenzyl)-6-[(5-methylpyridin-2-yl)methoxy]-1H-benzimidazol-2-yl}-2,2-dimethylcyclopropanecarboxylic acid when purified by chiral SFC on (CHIRALPAK AD-H 5 μm 250×20 mm) mobile phase (60% CO 2 , 40% MeOH), and the first eluting isomer of racemic cis-2-{1-[2-Fluoro-4-(trifluoromethoxy)benzyl]-6-[(1-methyl-1H-pyrazol-3-yl)methoxy]-1H-benzimidazol-2-yl}cyclohexanecarboxylic acid when purified by chiral SFC (CHIRALCEL OD-H 5 μm 250×20 mm) mobile phase (80% CO 2 , 20% MeOH) are specifically disclaimed; and solvates, hydrates, and pharmaceutically acceptable salts thereof.