Patent ID: 9675687
Date: 2017-06-13
CPC Classifications: A61K,C07K,C12N,H05K

Claim:
1. A method of inducing an immune response against human immunodeficiency virus (HIV) or an HIV epitope in a subject, the method comprising administering to the subject at least one of the following: a nucleic acid composition comprising at least two different synthetic, codon-optimized nucleic acid molecules comprising a nucleotide sequence that has at least 90% identity to the nucleotide sequence of at least two of SEQ ID NO:1, 3, 5, 7, and 9, wherein one of the synthetic, codon-optimized nucleic acid molecules comprises a nucleotide sequence that has at least 90% identity to the nucleotide sequence of SEQ ID NO:5 or 7; and a polypeptide composition comprising at least two different isolated polypeptides encoded by a synthetic, codon-optimized nucleic acid molecule comprising a nucleotide sequence that has at least 90% identity to the nucleotide sequence of at least two of SEQ ID NO:1, 3, 5, 7, and 9, wherein one of the synthetic, codon-optimized nucleic acid molecules comprises a nucleotide sequence that has at least 90% identity to the nucleotide sequence of SEQ ID NO:5 or 7; wherein the nucleic acid composition and/or the polypeptide composition are administered in an amount sufficient to induce an immune response against HIV or an HIV epitope in the subject.