Patent ID: 9651563
Date: 2017-05-16
CPC Classifications: A61P,G01N

Claim:
1. A kit for the diagnosis or prognosis of liver fibrosis in a subject, comprising: labeled antibodies for detecting at least two liver fibrosis-related molecules, labeled nucleic acid probes for detecting at least two liver fibrosis-related molecules, labeled nucleic acid primers for detecting at least two liver fibrosis-related molecules, or combinations thereof, wherein the at least two liver fibrosis-related molecules comprise at least two of: receptor-type tyrosine-protein phosphatase gamma (PTPRG); sulfhydryl oxidase 1 (QSOX1); glutathione peroxidase 3 (GPX3); Ig kappa chain V-III region VG; Ig kappa chain V-III region HAH; Ig lambda chain V-III region LOI; Ig alpha-1 chain C region (IGHA1); Ig gamma-1 chain C region (IGHG1); Ig gamma-2 chain C region (IGHG2); Ig mu chain C region (IGHM); Ig kappa chain C region (IGKC); Ig kappa chain V-I region HK102 (IGKV1-5); Ig lambda chain C regions (IGLC1); low affinity immunoglobulin gamma Fc region receptor III-A (FCGR3A); alpha-2-macroglobulin (A2M); actin, cytoplasmic 1 (ACTB); afamin (AFM); Alpha-2-HS-glycoprotein (AHSG); CD166 antigen (ALCAM); apolipoprotein B-100 (APOB); apolipoprotein E (APOE); complement component C7; clusterin (CLU); extracellular matrix protein 1 (ECM1); hemoglobin subunit beta; inter-alpha-trypsin inhibitor heavy chain H3 (ITIH3); galectin-3-binding protein (LGALS3BP); mannose-binding protein C (MBL2); L-selectin; alpha-1-antitrypsin (SERPINA1); corticosteroid-binding globulin (SERPINA6); sex hormone-binding globulin (SHBG); vascular cell adhesion protein 1 (VCAM1); von Willebrand factor (VWF); prothrombin (F2); complement factor B (CFB); complement factor I (CFI); complement C1s subcomponent (C1S); complement C1r subcomponent (C1R); plasma kallikrein (KLKB1); coagulation factor XI (F11); coagulation factor IX (F9); Beta-Ala-His dipeptidase (CNDP1); cholinesterase (BCHE); serum albumin (ALB); serum amyloid P-component (APCS); apolipoprotein A-IV (APOA4); apolipoprotein C-III (APOC3); Beta-2-glycoprotein 1 (APOH); zinc-alpha-2-glycoprotein (AZGP1); complement C4-A (C4A); complement component C6 (C6); complement component C8 alpha chain (C8A); complement component C8 beta chain (C8B); complement component C8 gamma chain (C8G); complement component C9 (C9); fibrinogen alpha chain (FGA); hemopexin (HPX); histidine-rich glycoprotein (HRG); insulin-like growth factor-binding protein complex acid labile subunit (IGFALS); inter-alpha-trypsin inhibitor heavy chain H1 (ITIH1); inter-alpha-trypsin inhibitor heavy chain H2 (ITIH2); inter-alpha-trypsin inhibitor heavy chain H4 (ITIH4); alpha-1-acid glycoprotein 1 (ORM1); alpha-1-acid glycoprotein 2 (ORM2); proteoglycan 4 (PRG4); retinol-binding protein 4 (RBP4); alpha-1-antichymotrypsin (SERPINA3); antithrombin-III (SERPINC1); heparin cofactor 2 (SERPIND1); transthyretin (TTR); coagulation factor X (F10); fibronectin (FN1); complement C5 (C5); kallistatin (SERPINA4); vitronectin (VTN); lumican (LUM); hemoglobin subunit alpha (HBA1); plasma protease C1 inhibitor (SERPING1); Ig kappa chain V-I region AU; Ig kappa chain V-II region Cum Ig kappa chain V-IV region; N-acetylmuramoyl-L-alanine amidase (PGLYRP2); biotinidase (BTD); plasminogen (PLG); vitamin K-dependent protein C (PROC); complement C1r subcomponent-like protein (C1RL); carboxypeptidase N catalytic chain (CPN1); carboxypeptidase B2 (CPB2); apolipoprotein A-I (APOA1); complement C4-B (C4B); vitamin D-binding protein (GC); platelet glycoprotein V (GP5); haptoglobin (HP); insulin-like growth factor-binding protein 3 (IGFBP3); kininogen-1 (KNG1); vitamin K-dependent protein S (PROS 1); protein Z-dependent protease inhibitor (SERPINA10); pigment epithelium-derived factor (SERPINF1); alpha-2-antiplasmin (SERPINF2); thrombospondin-1 (THBS1); prostaglandin-H2 D-isomerase (PTGDS); carbonic anhydrase 1 (CA1); fructose-bisphosphate aldolase B (ALDOB); complement C2 (C2); coagulation factor XII (F12); mannan-binding lectin serine protease 2 (MASP2); hyaluronan-binding protein 2 (HABP2); aminopeptidase N (ANPEP); ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (ENPP2); ceruloplasmin (CP); peroxiredoxin-2 (PRDX2); alpha-1B-glycoprotein (A1BG); transforming growth factor-beta-induced protein ig-h3 (TGFB1); monocyte differentiation antigen CD14 (CD14); complement C3 (C3); endoglin (ENG); endothelial protein C receptor (PROCR); IgGFc-binding protein (FCGBP); ficolin-3 (FCN3); fetuin-B (FETUB); hepatocyte growth factor-like protein (MST1); cell surface glycoprotein MUC18 (MCAM); neuropilin-1 (NRP1); secreted phosphoprotein 24 (SPP2); thyroxine-binding globulin (SERPINA7); vasorin (VASN); collagen alpha-1(XVIII) chain (COL18A1); poliovirus receptor (PVR); apolipoprotein A-II (APOA2); Peptidase inhibitor 16 (PI16); GDH/6PGL endoplasmic bifunctional protein (H6PD); angiotensinogen (AGT); complement factor H (CFH); c-reactive protein (CRP); gelsolin (GSN); apolipoprotein C-I (APOC1); macrophage colony-stimulating factor 1 receptor (CSF1R); dopamine beta-hydroxylase (DBH); collagen alpha-3(VI) chain (COL6A3); cartilage oligomeric matrix protein (COMP); Ig lambda chain V-I region NEWM; intercellular adhesion molecule 1 (ICAM1); scavenger receptor cysteine-rich type 1 protein M130 (CD163); lymphatic vessel endothelial hyaluronic acid receptor 1 (LYVE1); phosphatidylcholine-sterol acyltransferase (LCAT); carboxypeptidase N subunit 2 (CPN2); vitamin K-dependent protein Z (PROZ); mannan-binding lectin serine protease 1 (MASP1); selenoprotein P (SEPP1); and retinoic acid receptor responder protein 2 (RARRES2), or any of SEQ ID NOS: 1-5544, wherein the labeled antibodies, labeled nucleic acid probes, and labeled nucleic acid primers comprise a fluorophore, chemiluminescent agent, enzyme, hapten, metal complex, or radioactive isotope.