Patent ID: 9543118
Date: 2017-01-10
CPC Classifications: B23K,C12Q,C23C,G01N,H01J

Claim:
1. A method for making a nanopore structure, the method comprising: drilling with a gold ion beam to define an aperture through a substrate and to introduce and embed gold ions within a wall of the aperture, the wall defining a first diameter; embedding the gold ions in a region confined to the wall of the aperture to a thickness of about 2 to about 40 nm; bonding a thiolated DNA strand to the embedded gold ions with covalent bond; and bonding a single-stranded DNA strand to the thiolated DNA strand with a hydrogen bond to define a substantially cylindrical nanopore, the substantially cylindrical nanopore defining a second diameter within the aperture; wherein the second diameter is less than the first diameter.