Patent ID: 9643958
Date: 2017-05-09
CPC Classifications: C07B,C07C,C07D

Claim:
1. A method to remove the t-butyldimethylsilyl group from a t-butyldimethylsilyl ether compound of a secondary or tertiary alcohol, comprising: preparing a reaction mixture by adding the t-butyldimethylsilyl ether compound and an acid substance to a mixture of water and a solvent selected from the group consisting of a nitrile, an amide and an ester; hydrolyzing the t-butyldimethylsilyl ether compound to obtain the secondary or tertiary alcohol; and isolating the secondary or tertiary alcohol from the hydrolyzed reaction mixture; wherein the acid substance is selected from the group consisting of an organic acid, a salt of an organic acid, an inorganic acid and a salt of an inorganic acid; and a pKa of the acid substance in water is from 1.0 to 3.0.