Patent ID: 9535247
Date: 2017-01-03
CPC Classifications: G01J,G01N,G02B

Claim:
1. An optical microscopy method for noninvasive imaging of a biological tissue, comprising: wavefront shaping using interferometric focusing to compensate for light scattering, wherein the interferometric focusing focuses light onto a guide-star in a biological tissue to illuminate the guide-star, wherein the guide-star is used for refractive and interferometric refocusing of the scattered light in the biologic tissue to correct for refractive phase aberrations and to shape the wavefront for un-scattering the scattered light inside the biological tissue; measuring fluorescence from the illuminated guide-star using wavefront sensing; wavefront shaping using geometric focusing based on the measured fluorescence from the guide-star to correct for aberrations; and applying the combined interferometric and geometric wavefront shaping in the optical microscopy method.