Patent ID: 9668473
Date: 2017-06-06
CPC Classifications: A01N,A61K,Y10S

Claim:
1. A process for obtaining biopolymeric nanoparticles containing Azadirachta indica A. Juss. (Neem) oil comprising the steps of: (a) separately forming (i) an aqueous phase comprising a nanoemulsion comprising Neem oil and water; and (ii) an organic phase comprising a biopolymer solution comprising a biopolymer dissolved in a water miscible organic solvent, wherein the biopolymer is dissolvable in acetone; (b) mixing the organic phase with the aqueous phase by slowly adding the organic phase to the aqueous phase with stirring so that the organic solvent diffuses into the aqueous phase and the polymer is deposited at an oil-water interface to form a biopolymeric nanoparticle colloidal dispersion; and then either (c1) directly forming the colloidal dispersion into nanoparticles by reducing a volume of the water and solvent in the colloidal dispersion to form the biopolymeric nanoparticles; or (c2) mixing the colloidal dispersion with a second aqueous phase comprising a non-ionic surfactant to stabilize the colloidal dispersion and then reducing a volume of the water and solvent in the colloidal dispersion to form the biopolymeric nanoparticles.