Patent ID: 9682080
Date: 2017-06-20
CPC Classifications: A61K,A61P,C07C,C07D

Claim:
1. A method of activating pyruvate kinase R in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein: W, X, Y and Z are each independently selected from CH or N; D and D A is optionally substituted aryl or optionally substituted heteroaryl; L is a bond, —C(O)—, —(CR R each R each R each R each R each R n is 0, 1, or 2; m is 1, 2 or 3; h is 0, 1, 2; and g is 0, 1 or 2.