Patent ID: 9718885
Date: 2017-08-01
CPC Classifications: A61P,C07K,C12P,Y10S

Claim:
1. A glycoengineered, recombinant antibody comprising an immunoglobulin G (IgG) Fc region containing N-linked oligosaccharides, wherein said antibody is isolated from a glycoengineered Chinese Hamster Ovary (CHO) host cell that has altered glycosyltransferase expression and has been engineered to have an increased proportion of nonfucosylated oligosaccharides in the Fc region compared to a corresponding antibody produced by the same host cell without altered glycosyltransferase expression, and wherein said antibody has increased Fc-mediated cellular cytotoxicity and/or Fc receptor binding affinity as a result of said increased proportion of nonfucosylated oligosaccharides.