Patent ID: 9655964
Date: 2017-05-23
CPC Classifications: A61K,A61P,C07K,G01N

Claim:
1. A binding protein that specifically binds TNF-α and IL-17, and comprises a first polypeptide chain and a second polypeptide chain, wherein the first polypeptide chain comprises VD1-(X1)n-VD2-C-(X2)n, wherein VD1 is a first antibody heavy chain variable domain; VD2 is a second antibody heavy chain variable domain; C is a heavy chain constant domain; X1 is a linker with the proviso that it is not CH1; X2 is an Fc region; and n is 0 or 1; wherein the VD1 or VD2 of the first polypeptide chain is a heavy chain variable domain that binds TNF-α and comprises a CDR-H1 comprising the amino acid sequence NYGII (SEQ ID NO: 813), a CDR-H2 comprising the amino acid sequence WINTYTGKPTYAQKFQG (SEQ ID NO: 814), and a CDR-H3 comprising the amino acid sequence KLFTTMDVTDNAMDY (SEQ ID NO: 815); and wherein the second polypeptide chain comprises VD1-(X1)n-VD2-C-(X2)n, wherein VD1 is a first antibody light chain variable domain; VD2 is a second antibody light chain variable domain; C is a light chain constant domain; X1 is a linker with the proviso that it is not a light chain constant domain; X2 does not comprise an Fc region; and n is 0 or 1; wherein, the VD1 or VD2 of the second polypeptide chain is a light chain variable domain that binds TNF-α and comprises a CDR-L1 comprising the amino acid sequence RASQDISQYLN (SEQ ID NO: 816), a CDR-L2 comprising the amino acid sequence YTSRLQS (SEQ ID NO: 817), and a CDR-L3 comprising the amino acid sequence QQGNTWPPT (SEQ ID NO: 818); wherein both VD1s bind one target protein and both VD2s bind the other target protein.