Patent ID: 9745380
Date: 2017-08-29
CPC Classifications: A61K,A61P,C07K

Claim:
1. A method of delivering a chemotherapeutic drug to a Trop-2 positive human cancer cell comprising exposing a Trop-2 positive human cancer cell to an immunoconjugate comprising: (i) a humanized anti-Trop-2 antibody or antigen-binding fragment thereof comprising the light chain complementarity determining region (CDR) sequences CDR1 (KASQDVSIAVA, SEQ ID NO:28); CDR2 (SASYRYT, SEQ ID NO:29); and CDR3 (QQHYITPLT, SEQ ID NO:30) and the heavy chain CDR sequences CDR1 (NYGMN, SEQ ID NO:31); CDR2 (WINTYTGEPTYTDDFKG, SEQ ID NO:32) and CDR3 (GGFGSSYWYFDV, SEQ ID NO:33); and (ii) a chemotherapeutic drug conjugated to the anti-Trop-2 antibody or fragment thereof, wherein the drug is a camptothecin or an antimitotic agent.