Patent ID: 9534033
Date: 2017-01-03
CPC Classifications: A61K,A61P,C07K

Claim:
1. A chimeric construct comprising a mutant interferon attached to an antibody that binds to a tumor-associated antigen, wherein: said antibody is a full-length antibody that binds a tumor-associated antigen; said antibody is attached to said mutant interferon by a peptide linker, the amino acid sequence of said linker consisting of the sequence SGGGGS (SEQ ID NO:81) or AEAAAKEAAAKAGS (SEQ ID NO:82); said mutant interferon is a mutant interferon alpha where the mutations in said mutant interferon consist of one or more mutations selected from the group consisting of H57Y, E58N, and Q61S wherein the position is relative to the human wildtype interferon α2; and wherein the construct when contacted to a tumor cell results in the killing or the inhibition of the growth or proliferation of the tumor cell.