Patent ID: 9629808
Date: 2017-04-25
CPC Classifications: A61K,A61P

Claim:
1. The sustained-release matrix preparation comprising: (A) a pharmacologically active drug, (B) a combination of cellulose derivatives consisting of: (C) mannitol, wherein, when the preparation is subjected to a dissolution test by the paddle method at rotation rates of 50 rpm and 200 rpm at 37±0.5° C. for 2 hours in 0.01 N hydrochloric acid, the preparation exhibits a difference in average percentage dissolution (value at the rotation rate of 200 rpm in the paddle method−value at the rotation rate of 50 rpm in the paddle method) of the pharmacologically active drug in the dissolution test medium of 10% or lower, or exhibits an average percentage dissolution ratio (value at the rotation rate of 200 rpm in the paddle method/value at the rotation rate of 50 rpm in the paddle method) of the pharmacologically active drug in the dissolution test medium of 2.0 or lower.