Patent ID: 9714451
Date: 2017-07-25
CPC Classifications: A61P,C12Q,G16B

Claim:
1. A method of detecting high risk multiple myeloma in a human subject diagnosed with monoclonal gammopathy of undetermined significance (MGUS), comprising the steps of: determining gene expression levels of GNG10, PNPLA4, KIAA1754, AHCYL1, MCLC, EVI5, AD-020, PARG1, CTBS, FUCA1, RFP2, FLJ20489, LTBP1, TRIP13, AIM2, SELI, SLC19A1, LARS2, OPN3, ASPM, CCT2, UBE21, STK6, FLJ13052, FLJ12525, BIRC5, CKS1B, CKAPl, MGC57827, DKFZp7790175, PFN1, ILF3, IFI16, TBRG4, PAPDl, EIF2C2, MGC4308, ENOl, DSG2, EXOSC4, TAGLN2, RUVBL1, ALDOA, CPSF3, MGC15606, LGALS1, RAD18, SNX5, PSMD4, RAN, KIF14, CBX3, TMPO, DKFZP586L0724, WEEl, ROBO1, TCOF1, YWHAZ, and MPHOSPH1 in plasma cells isolated from the human patient, wherein the gene expression levels are determined by isolating RNA from the plasma cells and contacting the isolated RNA or a cDNA derived therefrom with a nucleic acid probe specific for each gene; and comparing the expression levels to expression levels for each gene in a control sample from a normal healthy individual and detecting high risk multiple myeloma on the basis of the comparison, wherein: