Patent ID: 9574007
Date: 2017-02-21
CPC Classifications: A61K,A61N,A61P,C07K,G01N

Claim:
1. A method of treating cancer in a subject having a cancer comprising administering to the subject a composition comprising a therapeutically effective amount of an immunoglobulin polypeptide or an antigen-binding fragment thereof associated with a chemotherapeutic agent, wherein: said immunoglobulin polypeptide or antigen-binding fragment thereof specifically binds to an epitope of a B7-H3L protein that is expressed and exposed in its native conformation on the surface of a cancer cell of said cancer, wherein said epitope is insufficiently expressed on the surface of a living normal cell to exhibit binding by said immunoglobulin polypeptide; said immunoglobulin polypeptide or antigen-binding fragment thereof can be internalized into said cancer cell expressing B7-H3L; and said immunoglobulin polypeptide or antigen-binding fragment thereof comprises the amino acid sequences of complementarity determining regions of the monoclonal antibody expressed by the hybridoma having ATCC Deposit No. PTA-4217, ATCC Deposit No. PTA-4218, ATCC Deposit No. PTA-4244, or ATCC Deposit No. PTA-4245.