Patent ID: 9567605
Date: 2017-02-14
CPC Classifications: A61K,A61P,C07K,C12N

Claim:
1. A method of treating an angiogenic disease which is a solid tumor in a human subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of adenovirus particles via intravenous administration, wherein the adenovirus particles comprises an adenoviral nucleic acid, wherein said nucleic acid comprises a fas-chimera transgene transcriptionally linked to a PPE-1-3X promoter, wherein said PPE-1-3X promoter restricts expression of the fas-chimera transgene to angiogenic blood vessels, and wherein said therapeutically effective amount is about 3×10 12 to about 1×10 13 adenovirus particles and inhibits growth of the solid tumor.