Patent ID: 9566256
Date: 2017-02-14
CPC Classifications: A61F,A61K,A61P

Claim:
1. A formulation for topical delivery of an active ingredient to a mammal, said mammal having a body surface and the body surface having a topical application site comprising skin, the formulation comprising: a vasodilator, an osmolyte, and an active ingredient, wherein: a) the vasodilator is selected from the group consisting of arginine, methyl nicotinate, naftidrofuryl oxalate, papaverine, tolazoline, and combinations of the foregoing, b) the osmolyte is a sugar; c) the vasodilator and the osmolyte are present in amounts effective to work together in a synergistic manner to enable penetration of the active ingredient into or through the skin; d) the vasodilator, the osmolyte, and the active ingredient are non-identical; and e) the formulation has an osmolarity that is greater than 350 milliOsmol/L.