Patent ID: 9631011
Date: 2017-04-25
CPC Classifications: A61P,C07K

Claim:
1. An anti-gremlin-1 antibody, comprising a light-chain variable region and a heavy-chain variable region selected from the group consisting of those having the following amino acid sequences, respectively: a light-chain variable region comprising amino acids 23-35 of CDR1, amino acids 51-57 of CDR2, and amino acids 90-100 of CDR3 in an amino acid sequence of SEQ ID NO: 5 and a heavy-chain variable region comprising amino acids 26-35 of CDR1, amino acids 50-66 of CDR2, and amino acids 99-110 of CDR3 in an amino acid sequence of SEQ ID NO: 6; a light-chain variable region comprising amino acids 23-35 of CDR1, amino acids 51-57 of CDR2, and amino acids 90-100 of CDR3 in an amino acid sequence of SEQ ID NO: 7 and a heavy-chain variable region comprising amino acids 26-35 of CDR1, amino acids 50-66 of CDR2, and amino acids 99-110 of CDR3 in an amino acid sequence of SEQ ID NO: 8; and a light-chain variable region comprising amino acids 23-35 of CDR1, amino acids 51-57 of CDR2, and amino acids 90-100 of CDR3 in an amino acid sequence of SEQ ID NO: 9 and a heavy-chain variable region comprising amino acids 26-35 of CDR1, amino acids 50-66 of CDR2, and amino acids 90-110 of CDR3 in an amino acid sequence of SEQ ID NO: 10.