Patent ID: 9700024
Date: 2017-07-11
CPC Classifications: A01K,A61D,A61P,C12N

Claim:
1. A mouse pregnant with a mouse fetus, comprising: a placenta comprised of cells differentiated from transplanted cells transfected in vitro with a viral vector comprised of a nucleic acid sequence encoding human soluble fms-like tyrosine kinase 1 (sFLT1), the nucleic acid sequence operatively inserted in the viral vector in a manner such that the human sFLT1 protein is specifically expressed in the mouse placenta, wherein the pregnant mouse exhibits symptoms of a disease selected from the group consisting of pregnancy-induced hypertension syndrome, placental insufficiency, intrauterine growth retardation, glomerulosclerosis, and proteinuria as a result of the expression of the human sFLT1 protein in the mouse placenta; and wherein the human sFLT1protein is expressed in the mouse placenta throughout a gestational period of the mouse fetus.