Patent ID: 9546137
Date: 2017-01-17
CPC Classifications: A61P,C07D

Claim:
1. A method for producing N-[(3aR,4R,4aR,5aS,6S,6aS)-3,3a,4,4a,5,5a,6,6a-octahydro-1,3-dioxo-4,6-ethenocycloprop[f]isoindol-2(1H)-yl]-4-(trifluoromethyl)-benzamide, said method comprising: (a) reacting compound 3 of formula:  with tert-butyl carbazate (compound 5) to form compound 6 of formula: (b) reacting compound 6 with an acid to form compound 7 or salt thereof of formula: (c) reacting compound 7 with 4-(trifluoromethyl)benzoyl chloride (compound 8); and (d) collecting N-[(3aR,4R,4aR,5aS,6S,6aS)-3,3a,4,4a,5,5a,6,6a-octahydro-1,3-dioxo-4,6-ethenocycloprop[f]isoindol-2(1H)-yl]-4-(trifluoromethyl)-benzamide.