Patent ID: 9675685
Date: 2017-06-13
CPC Classifications: A61K,A61P,C07K,C12N

Claim:
1. A respiratory syncytial virus (RSV) fusion (F) protein comprising: (i) a deletion of 10 acids corresponding to amino acids 137-146 of the wild-type RSV F protein (SEQ ID NO: 2); and (ii) an inactivated primary furin cleavage site, corresponding to amino acids 131-136 of the wild-type RSV F protein (SEQ ID NO: 2), wherein the primary furin cleavage site is inactivated by substituting the amino acids at positions corresponding to arginine 133, arginine 135, and arginine 136 of the wild-type RSV F protein (SEQ ID NO: 2) with glutamine, and