Patent ID: 9682053
Date: 2017-06-20
CPC Classifications: A23L,A23V,A61K,A61P

Claim:
1. A composition comprising: (a) at least 500 mg of leucine and/or at least 200 mg of one or more metabolites thereof, wherein the one or more leucine metabolites are selected from the group consisting of keto-isocaproic acid (KIC), alpha-hydroxy-isocaproic acid, and HMB; and (b) at least 1 mg of a sirtuin pathway activator that is an anti-diabetic agent selected from the group consisting of a dipeptidyl peptidase (DPP) inhibitor, incretin and/or incretin mimetic; wherein the composition is substantially free of the individual amino acids alanine, glutamic acid, glycine, isoleucine, valine, and proline; wherein the composition is formulated as a tablet, capsule, gel capsule, beverage, snack bar or a food composition; wherein when (a) is a metabolite of leuine the molar ratio of (a) to (b) is greater than 10; and wherein when (a) is leucine, the molar ratio of (a) to (b) is greater than 500.