Patent ID: 9629850
Date: 2017-04-25
CPC Classifications: A61K,A61P

Claim:
1. A method of treating a patient suffering from a proliferative disorder, comprising administering to the patient a MEK inhibitor in combination with a selective inhibitor of Aurora A kinase that is 4-{[9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino}-2-methoxybenzoic acid, or a pharmaceutically acceptable salt thereof, wherein the proliferative disorder is selected from the group consisting of lung cancer, ovarian cancer, prostate cancer, pancreatic cancer, gastric cancer, head and neck squamous cell carcinoma, small cell lung cancer, melanoma and colorectal cancer, and wherein the MEK inhibitor is 3-[(2R)-2,3-dihydroxypropyl]-6-fluoro-5-[(2-fluoro-4-iodophenyl)amino]-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione, or a pharmaceutically acceptable salt thereof.