Patent ID: 9730894
Date: 2017-08-15
CPC Classifications: A61K,A61P

Claim:
1. A process for preparing a hot-melt extruded pharmaceutical composition comprising drug-containing particles dispersed in a stabilizing and non-solubilizing carrier, the process comprising: providing drug-containing particles of a therapeutic compound, wherein said particles have a mean particle diameter of 100 microns or less and comprise one or more amorphous or crystalline therapeutic compounds dispersed in one or more adjunct stabilizers; admixing said drug-containing particles with a stabilizing and non-solubilizing hot-melt extrudable carrier that does not solubilize, or solubilizes 10% drug weight or less of, the drug containing particles to form a particle-carrier admixture; and mixing and hot-melting extruding the charges particle-carrier admixture to form the hot-melt extruded pharmaceutical composition; wherein a substantial majority of the fine drug particles are not agglomerated or aggregated as a result of the step of hot-melt extruding.