Patent ID: 9663790
Date: 2017-05-30
CPC Classifications: A61K,A61P,C12N

Claim:
1. A recombinant nucleic acid construct suitable for the treatment of humans comprising at least one adipose-specific transcription regulating sequence that induces or enhances gene expression in large-cell adipocytes operably linked to at least one nucleic acid sequence, wherein the at least one nucleic acid sequence encodes an oligonucleic acid comprising at least one sequence complementary to a platelet-type 12-lipoxygenase (platelet-type 12-LO) gene or transcript thereof, and wherein the oligonucleic acid specifically inhibits or reduces the expression of platelet-type 12-LO, and wherein the at least one adipose-specific transcription regulating sequence comprises a recombinant chimeric promoter and enhancer having the nucleic acid sequence of SEQ ID NO: 8 or 9.