Patent ID: 9623115
Date: 2017-04-18
CPC Classifications: A61K,A61P,B82Y,C07K

Claim:
1. A complex comprising: a) a first antibody or antigen-binding fragment thereof that binds to CD38; and b) a second antibody or antigen-binding fragment thereof that binds to a antigen selected from the group consisting of CD2, CD3, CD23, CD25, CD40, CD52, CD74, CD80, CD147, and IL-6, wherein each antibody or fragment thereof is attached to an AD moiety or a DDD moiety; wherein the amino acid sequence of the DDD moiety is selected from the group consisting of residues 1-44 of human protein kinase A (PKA) RIIα and residues 1-44 of human PKA RIIβ; wherein the amino acid sequence of the AD moiety is from an anchoring domain of an A-kinase anchoring protein (AKAP); and wherein two copies of the DDD moiety form a dimer that binds to one copy of the AD moiety to form the complex.