Patent ID: 9617322
Date: 2017-04-11
CPC Classifications: A61K,A61P,C07K,Y02A

Claim:
1. A proNGF mutant wherein the protease cleavage site R 1 SK 3 R 4 is substituted at least at positions R 1 K 3 corresponding to positions 101 and 103 of the human wild type proNGF sequence (SEQ ID NO: 1) wherein the amino acid in position 101 of human wild type proNGF sequence (SEQ ID NO: 1) is substituted by Valine, in position 103 by Alanine, and wherein the amino acid at position 102 is Serine and the amino acid at position 104 is Arginine, or wherein the proNGF mutant comprises the amino acid sequence of SEQ ID NO: 5.