Patent ID: 9574167
Date: 2017-02-21
CPC Classifications: C12M

Claim:
1. A microreactor apparatus to perform a continuous bioreaction process in a fluid wherein the dilution rate of cells and the dilution rate of a product can be different, comprising: a reaction chamber comprising a first sub-chamber having a reconfigurable first volume fluidically coupled through a connecting conduit to a second sub-chamber having a reconfigurable second volume; an input conduit fluidically connecting an inlet to the microreactor apparatus to the reaction chamber; a first output conduit fluidically connecting the reaction chamber to a first outlet of the microreactor apparatus; a filter that restricts the passage of cells from a first side of the filter to a second side of the filter, wherein the first side is fluidically connected to the reaction chamber and the filter is mounted such that all fluid paths from the reaction chamber to the second side of the filter pass through the filter; and a second output conduit fluidically connecting the second side of the filter to a second outlet of the microreactor.