Patent ID: 9550011
Date: 2017-01-24
CPC Classifications: A61F,A61L,G02C

Claim:
1. An article for use as a biological implant or prosthetic, the article comprising a substrate, and a grafted coating polymer covalently attached to the substrate through a reactive group selected from the group consisting of OH, NHS, HOBt, NH 2 , CO 2 H, CHO, SH and epoxide, and combinations thereof; wherein the grafted coating polymer comprises a copolymer of (a) (N-vinylpyrrolidone), (N,N-dimethylacrylamide), (N-methyl-N-vinylacetamide), (N-vinylformamide), (ethylene glycol), (methacryloyl phosphorylcholine), or (ethylene oxide), or a combination thereof; and (b) PEG acrylate, PEG methacrylate, (vinyl alcohol), (acrylic acid), (acrylic acid) sodium salt, or (acrylic acid) potassium salt, acrylic acid N-hydroxysuccinimide ester, alginic acid, hyaluronic acid, or a combination thereof, and wherein the grafted coating polymer is capable of resisting cell adhesion, protein deposition, or a combination thereof.