Patent ID: 9579283
Date: 2017-02-28
CPC Classifications: A61K,A61P,C07K,C12N

Claim:
1. A cell-targeting porous protocell composition comprising a plurality of protocells, the protocells comprising: a nanoporous silica or metal oxide core with a supported lipid bilayer; a Met binding peptide selected from the group consisting of SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, and SEQ ID NO: 5, wherein the Met binding peptide is attached to the supported lipid bilayer; a fusogenic peptide that promotes endosomal escape, wherein the fusogenic peptide is attached to the supported lipid bilayer; and a cargo loaded into the protocell, wherein the cargo is selected from the group consisting of: wherein the cargo is optionally conjugated to a nuclear localization sequence.