Patent ID: 9605030
Date: 2017-03-28
CPC Classifications: A61K,A61P,C07K,C12N,G01N

Claim:
1. A polypeptide capable of eliciting neutralizing antibodies against a virus, wherein the polypeptide comprises a variant HIV-1 gp120 or an immunogenic fragment thereof, and further wherein the variant gp120 or the immunogenic fragment thereof is selected from the group consisting of a polypeptide which comprises at least one mutation at a position selected from the group consisting of positions 88, 131, 132, 138, 160, 191, 203, 225, 479, 507, 604 and 647 with respect to the numbering of SEQ ID NO:2, wherein the polypeptide or the immunogenic fragment thereof comprises a sequence selected from the group consisting of SEQ ID NOs:4, 17, 19-29, and 31.