Patent ID: 9540382
Date: 2017-01-10
CPC Classifications: A61J,A61K,A61P,B65D,C07B,C07D

Claim:
1. A method of treating cancer in a mammal comprising administering to the mammal a pharmaceutical formulation comprising: (a) about 40 mgs to about 200 mgs of 1-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one; (b) about 40 wt % to about 50 wt % of a diluent; (c) about 3 wt % to about 10 wt % of a disintegrating agent; (d) about 2 wt % to about 7 wt % of a surfactant; and (e) about 0.2 wt % to about 1.0 wt % of a lubricant, wherein the cancer is (i) a B cell malignancy, (ii) lymphoma, leukemia, or a solid tumor, or (iii) diffuse large B cell lymphoma, follicular lymphoma, small lymphocytic lymphoma, chronic lymphocytic leukemia, B cell prolymphocytic leukemia, lymphoplasmacytic lymphoma/Waldenström macroglobulinemia, splenic marginal zone lymphoma, plasma cell myeloma, plasmacytoma, extranodal marginal zone B cell lymphoma, nodal marginal zone B cell lymphoma, mantle cell lymphoma, mediastinal (thymic) large B cell lymphoma, intravascular large B cell lymphoma, primary effusion lymphoma, burkitt lymphoma/leukemia, lymphomatoid granulomatosis, or multiple myeloma.