Patent ID: 9732114
Date: 2017-08-15
CPC Classifications: A61K,C07H

Claim:
1. A method of inhibiting cell adhesion, comprising contacting said cells with a compound having a structure represented by o-(x-L)n, where (a) o is a polynucleoside moiety comprising a sequence of nucleosides and linkage moieties, wherein (i) at least 50% of said linkage moieties are selected from: 3′-NH—P(O)(S − )-5′; 3′-NH—P(O)(S—)—{OR} m —Y—P(O)(S − )-5′; and 3′-Y—R—O—P(O)(S − )-5′, where Y is NH or O; R is a stable linear chain two to six atoms in length having bonds selected from alkyl, alkenyl, ether, thioether, and amino; and m is 1 to 3; and (ii) said sequence includes at least one motif selected from GGG and GG(W) 1-3 GG, containing residues G and/or W, where G is guanosine and W is a nucleoside or the moiety —O—R—, where R is as defined above, and the inter-residue linkages within said motif are N3′→P5′ thiophosphoramidate (3′-NH—P(O)(S—)-5′) or phosphorothioate (3′-O—P(O)(S—)-5′) linkages; (b) x is an optional linker group, (c) L is a lipid moiety, and (d) n is 1 or 2; wherein the compound is not a telomerase inhibitor.