Patent ID: 9605252
Date: 2017-03-28
CPC Classifications: A61K,C12N,C12P,C12Q,C12Y

Claim:
1. A recombinant tyrosine ammonia lyase comprising an amino acid sequence comprising at least 90%, sequence identity to SEQ ID NO: 14, wherein said recombinant tyrosine ammonia lyase comprises a mutation at position 107 and at least one mutation selected from the group consisting of position 18, 47, 54, 59, 64, 73, 77, 88, 91, 93, 95, 97, 108, 214, 219, 222, 253, 304, 307, 315, 364, 367, 389, 394, 396, 400, 401, 423, 447, 453, 462, 490, 500, 503, 521, 550, 554, 564, and 56 of SEQ ID NO: 14 and wherein said recombinant tyrosine ammonia lyase is thermostable.