Patent ID: 9676701
Date: 2017-06-13
CPC Classifications: A61P,C07B,C07C,C07D

Claim:
1. A compound of Formula (I) or an enantiomer, a diastereomer, or a mixture thereof, or a pharmaceutically acceptable salt or solvate thereof: wherein: E is —X (G) is an aryl or heterocyclyl group; each (R1) is independently chosen from alkyl, alkenyl, alkynyl, cyclyl, -L1-cyclyl, -L1-amino, -L1-hydroxyl, amino, amido, nitro, halo, haloalkyl, haloalkoxy, cyano, sulfinyl, sulfonyl, sulfonamide, hydroxyl, alkoxy, urea, carbamate, acetyl, and carboxyl; each (R2) is independently chosen from H, alkyl, alkenyl, alkynyl, cyclyl, -L1-cyclyl, -L1-amino, -L1-hydroxyl, amino, amido, nitro, halo, haloalkyl, haloalkoxy, cyano, sulfinyl, sulfonyl, sulfonamide, hydroxyl, alkoxy, urea, carbamate, acyl, and carboxyl, wherein each (R2) group has 1, 2, or 3 independently chosen optional substituents or two (R2) groups can be taken together to form a heterocyclyl or aryl group having 1, 2, or 3 independently chosen optional substituents, wherein said optional substituents are independently chosen from alkyl, alkanoyl, heteroalkyl, heterocyclyl, haloalkyl, cycloalkyl, carbocyclyl, arylalkoxy, heterocyclylalkoxy, aryl, aryloxy, heterocyclyloxy, alkoxy, haloalkoxy, oxo, acyloxy, carbonyl, carboxyl, carboxamido, cyano, halogen, hydroxyl, amino, aminoalkyl, amidoalkyl, amido, nitro, thiol, alkylthio, arylthio, sulfonamide, sulfinyl, sulfonyl, urea, and carbamate; each L1 is independently alkylene or heteroalkylene; and n is 0, 1, 2, 3, 4 or 5; with the proviso that the compound of Formula (I) is not: (1S,2R)-2-([1,1′-biphenyl]-4-yl)cyclopropanamine, (1 S,2R)-2-(4′-chloro-[1,1′biphenyl]-4-yl)cyclopropanamine, (1 S,2R)-2-(3-chloro-4-(trifluoromethyl)-[1,1′-biphenyl]-4-yl)cyclopropanamine, 2-(3,4′,5-trichloro-[1,1′-biphenyl]-4-yl)cyclopropanamine, 2-(3,3′,4′,5-tetrachloro[1,1′-biphenyl]-4-yl)cyclopropanamine, 2-(3,3′,4′-trichloro-[1,1′-biphenyl]-4-yl)cyclopropanamine, or 2-(3,5-dichloro-4′-methyl-[1,1′-biphenyl]-4-yl)cyclopropanamine.