Patent ID: 9675567
Date: 2017-06-13
CPC Classifications: A61K,A61P,C07C,C07D

Claim:
1. A method of enhancing KCNQ2/KCNQ3 voltage-dependent potassium channels, wherein diseases treatable by such enhancement are selected from the group consisting of Lower Urinary Tract Disorders, Gynaecological Pain, Cardiac Arrhythmias, Thromboembolic Events, Cardiovascular Diseases, Gastrointestinal Disorders and Visceral Smooth Muscle Disorders, the method comprising administering to a patient in need thereof an effective amount of a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein: Ar a is 1; R b is an integer of from 0 to 3; R V is (CR W is NR X is a substituent selected from the group consisting of hydroxyalkyl having from 1 to 4 carbon atoms, polyalkylene glycol residue of general formula: wherein c1 and c2 are the same or different and each is an integer of from 1 to 3, c3 is an integer of from 1 to 10 and R Y and Z are each a group of formula (CR R p is an integer of from 0 to 2.