Patent ID: 9551018
Date: 2017-01-24
CPC Classifications: C12N,C12P,C12Y

Claim:
1. A process for the preparation of a compound selected from a group consisting of 3-aminopyrrolidone derivatives, chephalosporine, derivatives of cephalosporine, heterocyclic boronic acids, L-dihydroxphenylalanine (L-Dopa), α-methyldopa, D-phenylglycine, β-hydroxyphenylglycine, phosphinothricine, pyrimido derivatives and pyrrolidone derivatives, the process comprising: a) providing an amino acceptor and an amino donor, b) reacting the amino acceptor and the amino donor with a transaminase, c) obtaining a desired optically active chiral amine and a ketone by-product, and d) converting the optically active chiral amine to the compound, and wherein the amino acceptor is selected from a group consisting of phenylpyruvic acid, a salt thereof, pyruvic acid, a salt thereof, 2-ketoglutarate, 3-oxobutyrate, 2-butanone, 3-oxopyrrolidine, 3-pyridylmethylketone, 3-oxobutyric acid ethyl ester, 3-oxopentanoic acid methyl ester, N-1-boc-3-oxopiperidinone, N-1-boc-3-oxopyrrolidine, 3-oxo-piperidine, alkyl-3-oxo-butonoates, methoxy-acetone and 1-oxotetralone.