Patent ID: 9605083
Date: 2017-03-28
CPC Classifications: A61K,A61P,C07K

Claim:
1. A chimeric JAML antibody that substantially prevents human JAML from binding CAR having CDR1, CDR2, and CDR3 heavy chain respective sequences of: (SEQ ID NO:1) DYEMH; amino acid residues 46 to 68 of SEQ ID NO: 19; and (SEQ ID NO: 3) TRRRYYGSSYNWYFDV; and having CDR1, CDR2, and CDR3 light chain respective sequences of: (SEQ ID NO. 10) CRASENIYYSLAW; (SEQ ID NO. 11) NANSLEDGVPSR; and (SEQ ID NO. 12) YFCEQTYDVPLTFGAGT, wherein the antibody does not substantially bind to JAMA or JAMC.