Patent ID: 9561352
Date: 2017-02-07
CPC Classifications: A61K,A61M,A61P

Claim:
1. A drug delivery device, comprising: a non-erodible, non-porous housing member defining a reservoir, said housing member having a water impermeable outer surface and first and second opposing ends; a porous partition positioned in the first end of the housing member; contained within said reservoir, a drug formulation comprised of a sparingly water soluble drug and a solubility-modifying excipient, said sparingly water soluble drug having a soluble form and an insoluble form, wherein the insoluble form of the drug is retained in the reservoir, and wherein said solubility-modifying excipient is capable of generating acid groups to provide a concentration of the drug, in an aqueous suspension when the drug formulation is hydrated, to provide release of a therapeutic dose of the drug from the device over a period of between about 2-12 months, as the soluble form of the drug freely diffuses out of the device across said partition; and wherein release of the therapeutic dose is dependent on pH of the drug formulation and independent of pore size of the porous partition.