Patent ID: 9623103
Date: 2017-04-18
CPC Classifications: A61K,A61P,C07K,C12N,G16B

Claim:
1. A porcine reproductive and respiratory syndrome virus (PRRSV) comprising a nucleic acid encoding ORF1a or a functional part thereof, wherein said nucleic acid comprises at least one mutation resulting in reduced translation of a transframe (TF) domain of nsp2TF and/or altered translation of one or more downstream products translated from said nucleic acid, in a cell infected by said PRRSV, when compared to a wild-type of said PRRSV, wherein said mutation interferes with −2 ribosomal frameshifting at a −2 frameshifting site located in the nucleic acid sequence that codes for the nsp2 protein GGU(U/C)U(U/C)U and/or the conserved CCCANCUCC motif.