Patent ID: 9622486
Date: 2017-04-18
CPC Classifications: A01N,A61K,A61P,C07K,C12N

Claim:
1. A sterile pharmaceutical composition comprising a pharmaceutically acceptable excipient and a chimeric polypeptide comprising: (i) a first sequence having at least 90% identity to the sequence of amino acids 669-808 of SEQ ID NO:1; and (ii) a heterologous cell binding domain (CBD) that binds to a target bacterium, wherein the CBD has a sequence with at least 90% identity to a sequence selected from the group consisting of: amino acids 144-240 of SEQ ID NO:4, amino acids 149-257 of SEQ ID NO:8, and amino acids 144-243 of SEQ ID NO:12; wherein the target bacterium exhibits reduced or no growth after being contacted with the sterile pharmaceutical composition.