Patent ID: 9701739
Date: 2017-07-11
CPC Classifications: A61K,A61P,C07K

Claim:
1. A monoclonal antibody or an antigen binding fragment thereof, which binds to a peptide comprising an amino acid sequence represented by SSVLYGGPPSAA (SEQ ID NO: 1) or a conjugate of the peptide and a pharmaceutically acceptable carrier, the monoclonal antibody or an antigen binding fragment thereof having a higher binding affinity for core histone than for histone H1, wherein the monoclonal antibody or an antigen binding fragment thereof comprises: a light chain variable region comprising CDR1 consisting of an amino acid sequence represented by RASSSVSYMH (SEQ ID NO: 2), CDR2 consisting of an amino acid sequence represented by ATSNLAS (SEQ ID NO: 3), and CDR3 consisting of an amino acid sequence represented by QQWSSNPWT (SEQ ID NO: 4), and a heavy chain variable region comprising CDR1 consisting of an amino acid sequence represented by GYNMN (SEQ ID NO: 7), CDR2 consisting of an amino acid sequence represented by NINPYYGSTSYNQKFKG (SEQ ID NO: 8), and CDR3 consisting of an amino acid sequence represented by SPYYSNYWRYFDY (SEQ ID NO: 9).