Patent ID: 9695408
Date: 2017-07-04
CPC Classifications: A61K,A61P,C07K,C12N,C12Y

Claim:
1. A mutant streptokinase polypeptide comprising substitution of one to six amino acid residues of SEQ ID NO: 1 with cysteine residue, wherein the amino acid residue substituted with said cysteine residue is selected from the group consisting of G49, S57, A64, 188, S93, D95, D96, D102, S105, D120, K121, D122, E148, K156, D173, D174, L179, D181, S205, A251, 1254, N255, K256, K257, S258, L260, E281, K282, F287, D303, L321, L326, A333, D347, D360 and R372.