Patent ID: 9605079
Date: 2017-03-28
CPC Classifications: A61K,A61P,C07K,C12N,G01N

Claim:
1. An isolated protein comprising two monoclonal antibody variable regions capable of binding to peptidase inhibitor 16 (PI16), wherein one of the variable regions is an antibody heavy chain variable region (VH) and the other variable region is an antibody light chain variable region (VL), wherein the protein is also capable of competitively inhibiting binding of an antibody produced by a hybridoma designated CRCBT-02-001 deposited with the ATCC under Accession Number PTA-10685 to PI16, and wherein (i) the variable s are from the antibody produced by a hybridoma designated CRCBT-02-001 deposited with the ATCC under Accession Number PTA-10685; or (ii) the variable regions comprise CDRs of a heavy chain variable region comprising a sequence set forth in SEQ ID NO: 8 and CDRs of a light chain variable re ion comprising a sequence set forth in SEQ ID NO: 10.