Patent ID: 9545384
Date: 2017-01-17
CPC Classifications: A61K

Claim:
1. A pharmaceutical composition comprising nanoparticles, said nanoparticles comprising: (a) a poorly water soluble drug having a solubility in water of less than 5 mg/ml over the pH range of 6.5 to 7.5 at 250 C, at least 90 wt % of said drug in said nanoparticles being non-crystalline; (b) a poorly aqueous soluble non-ionizable cellulosic polymer having an ether- or ester-linked alkyl substituent; and (c) tocopheryl polyethylene glycol succinate (TPGS); wherein said nanoparticles have an average size of less than 500 nm; and said drug, said non-ionizable cellulosic polymer, and said TPGS collectively constitute at least 60 wt % of said nanoparticles.