Patent ID: 9603798
Date: 2017-03-28
CPC Classifications: A61K,A61P,C07K

Claim:
1. An antibody-conjugated double-emulsion nanocapsule, comprising: an aqueous core; an oily shell enclosing the aqueous core, wherein a composition of the oily shell comprises a polymer and a plurality of hydrophobic magnetic nanoparticles but does not comprise other polymers and surfactants, and wherein the polymer is a linking polyvinyl alcohol or a combination of polyvinyl alcohol (PVA) and a linking polymer, and the linking polyvinyl alcohol and the linking polymer have a linking group; and at least an antibody chemically bonded to the linking group via a coupling agent, wherein a diameter of the antibody-conjugated double-emulsion nanocapsule is about 50 nm to about 400 nm; wherein the linking polyvinyl alcohol is carboxymethylated polyvinyl alcohol (CMPVA), thiolated polyvinyl alcohol (TPVA), or a copolymer of PVA-TPMAA.