Patent ID: 9629713
Date: 2017-04-25
CPC Classifications: A61F,A61L

Claim:
1. A biomedical implant for use in a fluid shear stress environment of a subject, said biomedical implant comprising: a patterned surface having a plurality of cellular niches effective to maintain at least one localized layer of living cells within the plurality of cellular niches by decreasing fluid shear stress within the cellular niches as compared to fluid shear stress measured outside of the cellular niches, said cellular niches being effective to decrease peak fluid shear stress within the cellular niches to between about 5 and about 100 percent (%) of peak fluid shear stress measured outside of the cellular niches, wherein each cellular niche comprises a crevice formed into the surface of the biomedical implant, each crevice having (i) a top, open end located at the surface of the biomedical implant, (ii) a bottom, substantially closed end located at a region furthest below the surface of the biomedical implant, and (iii) opposing sidewalls that extend from the top end to the bottom end of the crevice, and wherein each crevice has a depth and width sufficient to maintain and retain a plurality of viable cells within the crevice, including at the bottom of the crevice and/or on one or more of the sidewalls of the crevice, said depth of each crevice being between about 100-1500 microns (μm) and said width of each crevice being between about 100-1000 μm, and wherein spacing between each cellular niche is between about 1-600 μm.