Patent ID: 9738688
Date: 2017-08-22
CPC Classifications: A61K,C07K,C12N

Claim:
1. An engineered or non-naturally occurring HIV-1 envelope glycoprotein isolated from a BG505 virus and having a SOSIP mutation wherein the glycoprotein is a BG505 SOSIP.664 gp140 trimer and wherein the SOSIP mutation comprises one or more mutations of the wild type amino acid alanine (A) or by wild type amino acid threonine (T) substitution with cysteine (C) (SOS mutation) and/or a mutation of the wild type amino acid isoleucine (I) by substitution with proline (P) (IP mutation); wherein the BG505 SOSIP.664 gp140 trimer is more compact than a KNH1144 SOSIP.664G trimer isolated from with respect to envelope volume; and wherein the BG505 SOSIP.664 gp140 trimer has a thermal denaturation midpoint (TM) of about 68 C.