Patent ID: 9669049
Date: 2017-06-06
CPC Classifications: A61K,A61N,A61P,C12N

Claim:
1. A composition comprising: a steroid or an inhibitor of a pattern recognition receptor (PRR) or an interferon (IFN) signaling pathway inhibitor, wherein the inhibitor of PRR is an antagonist of toll-like receptor-7 (TLR7) or TLR8 or an inhibitor of downstream TLR signaling, and wherein the IFN signaling pathway inhibitor is selected from the group consisting of an anti-IFN antibody, anti-IFN receptor antibody, and a combination thereof, and wherein the composition further comprises a recombinant replication-competent gammaretrovirus or a viral vector encoding a replication-competent gammaretrovirus.