Patent ID: 9540444
Date: 2017-01-10
CPC Classifications: A61K,A61P,C07K

Claim:
1. An isolated antibody that binds a Toll-like receptor 4 (TLR4)/MD-2 complex, wherein the antibody comprises: (a) a variable heavy chain complementarity determining region 1 (VH CDR1) comprising the amino acid sequence DSYIH (SEQ ID NO:3); (b) a variable heavy chain complementarity determining region 2 (VH CDR2) comprising the amino acid sequence WTDPENVNSIYDPRFQG (SEQ ID NO:4); (c) a variable heavy chain complementarity determining region 3 (VH CDR3) comprising the amino acid sequence GYNGVYYAMDY (SEQ ID NO:5); (d) a variable light chain complementarity determining region 1 (VL CDR1) comprising the amino acid sequence SASSSVIYMH (SEQ ID NO:8); (e) a variable light chain complementarity determining region 2 (VL CDR2) comprising the amino acid sequence RTYNLAS (SEQ ID NO:9); and (f) a variable light chain complementarity determining region 3 (VL CDR3) comprising the amino acid sequence HQWSSFPYT (SEQ ID NO:10).