Patent ID: 9566350
Date: 2017-02-14
CPC Classifications: A61K,C07K

Claim:
1. A lyophilized nanoparticle composition comprising nanoparticles having an outside surface, wherein each of the nanoparticles comprises: a) albumin; b) between about 100 to about 1000 antibodies having an Fc portion and an antigen-binding portion; and c) paclitaxel; said nanoparticles being lyophilized, and wherein upon reconstitution with an aqueous solution antigen-binding portions of said antibodies are arranged on the outside surface of the nanoparticles and are capable of binding to VEGF in vivo wherein said antibody is a humanized antibody, a chimeric antibody, a non-human antibody, a monoclonal antibody, a CDR-grafted antibody, a multispecific antibody, a dual specific antibody, an anti-idiotypic antibody, a bispecific antibody, a functionally active epitope-binding fragment thereof, or a bifunctional hybrid antibody, and wherein the average size of the nanoparticles is between 130 nm and 800 nm.