Patent ID: 9539318
Date: 2017-01-10
CPC Classifications: A61K,A61P

Claim:
1. A method for epicutaneous desensitization of a subject allergic to an allergen, the method comprising: a) determining a dose of the allergen which causes a local inflammatory reaction on the skin of the subject upon epicutaneous application thereof; b) epicutaneously exposing the subject to the allergen and generating the local inflammatory reaction in the subject by applying said dose of the allergen, without an adjuvant, on to an intact region of skin of the subject; and c) repeatedly applying the allergen, without an adjuvant, to an intact region of the skin of the subject, at a dose, frequency or for an application time adapted to sustain a local inflammatory reaction, the exposure and sustained reaction leading to desensitization of the subject; wherein the allergen is applied by means of a cutaneous occlusive device configured to ensure contact between the allergen and the region of skin, and wherein said dose of allergen is comprised between 0.1 and 1,000 μg/cm