Patent ID: 9724425
Date: 2017-08-08
CPC Classifications: A61K,A61P,C07K

Claim:
1. A conjugate comprising an IGF-I (insulin-like growth factor I) variant and poly(ethylene glycol), wherein the IGF-I variant has amino acid alterations from wild-type IGF-I at positions 27 and 65 or at positions 27 and 68, and the amino acid alterations do not reduce in vitro binding affinity for an IGF-I binding protein and in vitro IGF-I receptor phosphorylation; wherein the IGF-I variant selected from the group consisting of R27, R37, R65, K68 (RRRK) and R27, R37, K65, R68 (RRKR) and wherein the poly(ethylene glycol) is conjugated to the IGF-1 variant via a lysine primary amino group without poly(ethylene glycol) being conjugated to the N-terminus of the IGF-I variant.