Patent ID: 9707280
Date: 2017-07-18
CPC Classifications: A61K,A61P,C12N,C12Y

Claim:
1. A polypeptide comprising an amino acid sequence at least 85% identical to the amino acid sequence of SEQ ID NO:1 residues 1-567, wherein (a) the polypeptide degrades a PQPQLP (SEQ ID NO:34) peptide at pH 4; (b) residue 467 is Ser, residue 267 is Glu, and residue 271 is Asp; and (c) the polypeptide comprises one or more amino acid changes from SEQ ID NO: 33 at one or more residues selected from the group consisting of amino acid residues 119, 291, 292, 293, 319, 354, 357, 358, 361, and 368.