Patent ID: 9644033
Date: 2017-05-09
CPC Classifications: A61K,A61P,C07K

Claim:
1. A method of killing undesired target tumor cells in a patient, the method comprising administering to a patient in need thereof an effective amount of a multimeric protein construct, the multimeric protein construct comprising a multimerizing scaffold bearing (i) at least one targeting moiety that is capable of binding to the target tumor cells, and (ii) at least two effector immunogenic moieties that are non-toxic by themselves, wherein the multimerizing scaffold comprises the C-terminal part of the alpha chain of C4BP protein, the C-terminal part of the beta chain of C4BP protein, or a multimerizing fragment thereof the at least two effector immunogenic moieties are each fragment C of tetanus toxin (TTFgC); the at least one targeting moiety is an antibody or a binding fragment thereof against a tumor-associated antigen of the target tumor cells; and the multimeric protein construct redirects an anti-tetanus immune response that was pre-existing in the patient, toward the target tumor cells.