Patent ID: 9707218
Date: 2017-07-18
CPC Classifications: A61K,C07D

Claim:
1. A method of treating a disease or condition selected from lung cancer, non-small cell lung cancer, cutaneous or intraocular melanoma, colorectal cancer, colon cancer, gastric cancer, breast cancer, small intestinal cancer, cancer of the urethra, cancer of the prostate, lymphoma, sarcoma of soft tissue, cancer of the bladder, cancer of the kidney or ureter, renal cell carcinoma, neoplasms of the central nervous system (CNS), glioblastoma, brain stem glioma, neuroblastoma, pituitary adenoma, solid tumors or a combination of one or more of the foregoing cancers in a subject comprising the step of administering to the subject in need thereof a compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein: R R X X X Y Y provided that X 1a , X 1b , X 2a and X 2b are each deuterium, or X 3a , X 3b , X 4a and X 4b are each deuterium, or X 1a , X 1b , X 2a , X 2b , X 3a , X 3b , X 4a and X 4b are each deuterium, or a pharmaceutical composition comprising the compound of Formula I or a pharmaceutically acceptable salt thereof.