Patent ID: 9616105
Date: 2017-04-11
CPC Classifications: A61K,A61P,C12N

Claim:
1. A method for the treatment and/or prevention of the worsening of an autoimmune disease in an organism, the method comprising: (a) administering a mutein of human interleukin-2 (hIL-2 mutein) to the organism, wherein said hIL-2 mutein has an amino acid substitution in at least one of the positions 20, 88 or 126, numbered in accordance with the hIL-2 wild type sequence as set forth in SEQ ID NO: 1; and (b) if necessary, repeating step (a), wherein the autoimmune disease is type I diabetes, multiple sclerosis, or systemic lupus erythematosus, and wherein the administration induces regulatory T cells in the organism.