Patent ID: 9603806
Date: 2017-03-28
CPC Classifications: A61K,A61P

Claim:
1. A capsule comprising: (1) an immediate release first dosage composition in the form of compressed minitablets, the immediate release first dosage composition comprising an antibiotic; and (2) a delayed release second dosage composition in the form of compressed minitablets, the delayed release second dosage composition comprising a proton pump inhibitor and a coating, wherein, when tested in a basket apparatus, the delayed release second dosage composition meets the two stage test dissolution profile in a basket apparatus: (a) release of not more than 10% by weight of the proton pump inhibitor in 120 min in an acid stage comprising 900 ml 0.1N HCl at 100 rpm; and (b) release of not less than 75% by weight of the proton pump inhibitor in 45 min in 900 ml phosphate buffer pH 6.8 at 100 rpm following the acid stage.