Patent ID: 9682040
Date: 2017-06-20
CPC Classifications: A61K,A61P,Y02A

Claim:
1. A method for making a depot comprising: (a) forming an oil-in-water emulsion including a phospholipid, an oil, at least one hydrophilic water-soluble pharmaceutically active agent selected from the group consisting of vancomycin, gentamicin, a pharmaceutically acceptable salt thereof and a mixture thereof and water; (b) converting the emulsion to a monophasic solution having a pH of between about 3 to about 6; (c) lyophilizing the monophasic solution to obtain a dry paste, (d) adding a viscosity modifying agent to the dry paste in an amount sufficient to obtain a viscosity modified solution, (e) removing at least some of the viscosity modifying agent to obtain a depot, and (f) sterilizing the depot, wherein the water present in the depot is no more than about 4 wt % relative to the total weight of the depot.