Patent ID: 9585373
Date: 2017-03-07
CPC Classifications: A01K,C07H,C07K,C12N

Claim:
1. A mouse comprising at an endogenous Major Histocompatibility Complex II (MHC II) α gene locus a nucleotide sequence encoding a chimeric human/mouse MHC II α polypeptide that comprises a human portion and a mouse portion, wherein the nucleotide sequence is expressed under regulatory control of an endogenous mouse MHC II α promoter, wherein the human portion of the chimeric MHC II α polypeptide comprises a human MHC II α2 domain, wherein the mouse portion comprises transmembrane and cytoplasmic domains of a mouse MHC II α polypeptide, and wherein the mouse expresses the chimeric human/mouse MHC II α polypeptide on a surface of an antigen presenting cell of the mouse.