Patent ID: 9687533
Date: 2017-06-27
CPC Classifications: A61K,A61P,C07K,C12N,C12Y,G01N

Claim:
1. A pharmaceutical composition, comprising a pharmaceutically-acceptable carrier and an isolated polynucleotide that encodes an aminoacyl-tRNA synthetase (AARS) polypeptide consisting of an amino acid sequence that is at least 95% identical to SEQ ID NO:53, or a fragment thereof which is 100 or more contiguous amino acids of SEQ ID NO:53, wherein the AARS polypeptide has an extracellular signaling activity of modulating cytokine release, and wherein the polynucleotide is selected from (a) a cDNA polynucleotide and (b) a modified mRNA polynucleotide, wherein the composition is substantially endotoxin free, and is encapsulated in a lipid particle, a liposome, a vesicle, a nanosphere or a nanoparticle.