Patent ID: 9744170
Date: 2017-08-29
CPC Classifications: A61K,A61P

Claim:
1. A solid dosage form comprising a first composition and a second composition, wherein: the first composition comprises from 40 mg to 180 mg of from 5 mg to 30 mg of from 25 mg to 120 mg of ritonavir, 70-85% by weight of copovidone; and 5% to 10% by weight of a pharmaceutically acceptable surfactant or a combination of pharmaceutically acceptable surfactants, wherein all percentages are weight percentages relative to the total weight of the first composition, and wherein Compound 1, Compound 2 and ritonavir are formulated in an amorphous solid dispersion; the second composition comprises from 75 mg to 900 mg (free acid equivalent) of a sodium monohydrate salt of 20-40% copovidone, and 20-40% hypromellose, wherein all percentages are weight percentages relative to the total weight of the second composition; when dissolved in 900 mL of a dissolution medium using a standard USP dissolution Apparatus 2 (paddle) operating at 100 RPM at 37° C., 50-60% Compound 1 in the solid dosage form is released within 1 hour, 50-60% Compound 2 in the solid dosage form is released within 1 hour, 50-60% ritonavir in the solid dosage form is released within 1 hour, and 0.5-2% Compound 4 in the solid dosage form is released within 1 hour, wherein the dissolution medium is 0.05 M sodium phosphate buffer (pH 6.8) with 15 mM cetyltrimethylammonium bromide (cTAB), and the total weight of the solid dosage form is from 1000 mg to 1600 mg.