Patent ID: 9610327
Date: 2017-04-04
CPC Classifications: A61K,A61P,C07K

Claim:
1. A method of reducing the size of a gonadal tumor mass in a subject in need of such treatment comprising administering to the subject: an effective amount of an isolated protein comprising a variant activin IIB receptor polypeptide (vActRIIB) wherein vActRIIB comprises a polypeptide sequence having at least 99% identity to the amino acid sequence set forth at amino acids 25 through 134 of SEQ ID NO: 18, wherein the polypeptide comprises an amino acid substitution at position 28, wherein the substitution at position 28 is selected from the group of amino acids consisting of A, W, and Y for E, and wherein the polypeptide is capable of binding myostatin, activin A, or GDF-11; and a chemotherapeutic agent.