Patent ID: 9682949
Date: 2017-06-20
CPC Classifications: A01N,A61P,C07D

Claim:
1. A method of preparing a compound of formula IV comprising: a. reacting a compound of formula II with a source of cyanide in the presence of water to give a compound of formula III and b. reducing the compound of formula III with a suitable reducing agent to give a compound of formula IV; or A) reacting a compound of formula VII with CH 3 NO 2 to give a compound of formula XI and B) reducing the compound of formula XI with a suitable reducing agent to give a compound of formula IV; or 1) homologating a compound of formula VII to give an ester of formula XII wherein R is C 1 -C 6 alkyl; 2) reducing the compound of formula XII using a suitable reducing agent to give a compound of formula XIII and 3) treating the compound of formula XIII with hydrazoic acid to give a compound of formula IV.