Patent ID: 9650637
Date: 2017-05-16
CPC Classifications: A61K,C12N,C12Y

Claim:
1. A method for treating an age-related disease comprising administering to a human subject in need thereof an effective amount of an agent which increases the activity of sirtuin-6 (SIRT6) by increasing the expression of the SIRT6 gene, wherein the agent inhibits binding of a SIRT6 expression inhibitor to a 3′UTR region of human mRNA encoding SIRT6, wherein the expression inhibitor binds to nucleotides 479-486, nucleotides 386-394, nucleotides 199-206, nucleotides 350-359 or nucleotides 455-463 of SEQ. ID NO. 2, and wherein the age-related disease is selected from the group consisting of Hutchinson-Gilford progeria syndrome, osteoarthritis, rheumatoid arthritis, chronic obstructive pulmonary disease, and Werner syndrome.