Patent ID: 9580515
Date: 2017-02-28
CPC Classifications: A61K,A61P,C07K,C12N,C12Q,G01N

Claim:
1. A method of identifying genetic predisposition of a subject to cardiac dysfunction associated with aberrant expression of neukinase, said method comprising: (a) detecting a level of expression of a polypeptide comprising SEQ ID NO:25 in a sample derived from said subject by contacting said sample with an anti-neukinase antibody comprising a detectable label, wherein said antibody is selective for a polypeptide sequence of SEQ ID NO:25 and detecting binding between said polypeptide and said antibody; (b) detecting a level of expression of said polypeptide in a control sample by contacting said control sample with said anti-neukinase antibody and detecting binding between said polypeptide and said antibody; and (c) comparing said detected level of expression of said polypeptide from said sample to said detected level of expression of said polypeptide in said control sample; wherein decreased expression of said polypeptide in said sample compared to said control sample indicates that said subject is genetically predisposed to cardiac dysfunction.