Patent ID: 9534034
Date: 2017-01-03
CPC Classifications: A01K,A61K,A61P,C07K

Claim:
1. A method for stimulating maturation of an immature male reproductive tract tissue, comprising administering to a post-pubescent male subject having a low sperm count as compared with a normal sperm count an effective amount of a human relaxin agonist, wherein the human relaxin agonist is human relaxin H2 which is a heterodimeric polypeptide comprising a first polypeptide chain comprising: (i) amino acids 4 to 27 of SEQ ID NO:3; (ii) amino acids 4 to 28 of SEQ ID NO:3; (iii) amino acids 4 to 29 of SEQ ID NO:3; (iv) amino acids 4 to 30 of SEQ ID NO:3; (v) amino acids 4 to 31 of SEQ ID NO:3; (vi) amino acids 4 to 32 of SEQ ID NO:3; (vii) amino acids 4 to 33 of SEQ ID NO:3; (viii) amino acids 4 to 34 of SEQ ID NO:3; (ix) amino acids 4 to 35 of SEQ ID NO:3; or (x) amino acids 4 to 36 of SEQ ID NO:3 and a second polypeptide chain comprising: (i) amino acids 4 to 27 of SEQ ID NO:4; (ii) amino acids 5 to 27 of SEQ ID NO:4; or (iii) amino acids 6 to 27 of SEQ ID NO:4 for a time period sufficient to stimulate tissue maturation, wherein said maturation is an increase in the number of viable sperm cells, as compared with tissue not contacted with the relaxin agonist.