Patent ID: 9562110
Date: 2017-02-07
CPC Classifications: A61P,C07K

Claim:
1. An antibody comprising: (a) a monovalent unit comprising a light chain-heavy chain pair having specificity to a tumor antigen selected from the group consisting of EGFR, Her2, EpCAM, CD20, CD30, CD33, CD47, CD52, CD133, CEA, gpA33, Mucins, TAG-72, CIX, PSMA, folate-binding protein, GD2, GD3, GM2, VEGF, VEGFR, Integrin, αVβ3, α5β1, ERBB2, ERBB3, MET, IGF1R, EPHA3, TRAILR1, TRAILR2, RANKL, FAP and Tenascin, wherein the heavy chain comprises a human or a humanized IgG1 Fc fragment; and (b) a single-chain unit comprising SEQ ID NO: 1 having specificity to CD3.