Patent ID: 9739784
Date: 2017-08-22
CPC Classifications: A61K,C07K,C12Q,G01N

Claim:
1. A method of evaluating potential for invasiveness, metastasis, or recurrence of a breast cancer of grade 2 or grade 3, comprising the steps of: obtaining a breast tissue sample of tumor cells or suspected tumor cells from a subject; contacting said sample with an antibody generated against a fusion protein comprising obscurin Ig domains 58/59 with the sequence shown in SEQ ID NO: 27; detecting expression levels or subcellular distribution of giant obscurin proteins in said sample; and assessing the expression levels or the subcellular distribution of the giant obscurin proteins in said cells, wherein a decreased expression level or altered distribution of the giant obscurin proteins in the cells of the sample, in comparison to a control non-invasive standard or to a sample taken from the subject at a different point in time, is indicative of an increased potential of at least one of the invasiveness, metastasis, or recurrence of the breast cancer.