Patent ID: 9708577
Date: 2017-07-18
CPC Classifications: C12M,C12N,C12P,G01N

Claim:
1. A method for producing a basic amino acid selected from the group consisting of L-lysine, L-arginine, and L-histidine by fermentation comprising culturing a microorganism having an ability to produce the basic amino acid in a culture medium contained in a culture tank to produce and accumulate the basic amino acid-in the culture medium, wherein total ammonia concentration of the culture medium is continually adjusted to be within a certain concentration range which is sufficient to enhance production of the basic amino acid during at least a part of the total culture process by using an ammonia-controlling apparatus, said ammonia-controlling apparatus comprising at least an ammonia feeder that supplies ammonia to the culture tank, an ammonia sensor, and a control part, wherein: the ammonia sensor responds to non-ionized ammonia in the culture medium contained in the culture tank, the control part comprises a processing unit and is connected to the ammonia feeder and the ammonia sensor, and the control part is configured to