Patent ID: 9585947
Date: 2017-03-07
CPC Classifications: A61K,A61P

Claim:
1. An immunomodulating complex being a fusion protein comprising: (a) a mutant subunit of the ADP-ribosylating A1-subunit of the cholera toxin (CTA1) that is the that is the K-CTA1-R7K/C187A mutant having the amino acid sequence of SEQ ID NO:2, (b) a peptide capable of binding to a specific cellular receptor, wherein said peptide is a dimer of a Protein A D-subunit; and (c) one or more epitopes associated with an autoimmune disease, wherein, the one or more epitopes are autoimmune epitopes associated with an autoimmune disease, and wherein the autoimmune disease is selected from the group consisting of insulin-dependent diabetes mellitus, multiple sclerosis, rheumatoid arthritis, autoimmune uveitis, primary biliary cirrhosis, myasthenia gravis, Sjögren's syndrome, pemphigus vulgaris, scleroderma, systemic lupus erythematosus, and Grave's disease.