Patent ID: 9717707
Date: 2017-08-01
CPC Classifications: A61K,A61P

Claim:
1. A solid pharmaceutical composition, comprising: (i) 10% to 30% by weight of at least a pharmaceutically active amount of a pharmaceutical substance selected from the group consisting of water-insoluble oxidatively-degradable statins, selected from cerivastatin, fluvastatin, lovastatin, pitavastatin, pravastatin, rosuvastatin, simvastatin or combinations thereof, (ii) 30% to 70% by weight lactose hydrate, (iii) 2% to 15% by weight microcrystalline cellulose, (iv) 11% to 25% by weight of a partially water-soluble pregelatinized starch, and (v) 0.2% to 4% by weight of at least one alkali and/or alkaline earth salt of stearic acid and/or stearyl fumaric acid, wherein the composition does not contains any antioxidatively active substances selected from chain terminators, reducing agents, free radical scavengers and complexing agents, wherein said solid composition has a grain size distribution with the values: grain size >500 μm: <10%, grain size 500 μm to 250 μm: <45%, grain size 250 μm to 100 μm: >35%, grain size <100 μm: <10%, wherein the sum of the percentage amounts of all grain sizes is 100%, wherein said solid composition omits solvents and residual solvents, and wherein the composition is present in the form of a pressed tablet.