Patent ID: 9737623
Date: 2017-08-22
CPC Classifications: A61K,C07K,G01N

Claim:
1. An isolated antibody or fragment thereof that binds an activatable antibody or conjugated activatable antibody, wherein the antibody or fragment thereof comprises a combination of complementarity determining region (CDR) comprising a variable heavy chain complementarity determining region 1 (VH CDR1) sequence, a variable heavy chain complementarity determining region 2 (VH CDR2) sequence, a variable heavy chain complementarity determining region 3 (VH CDR2) sequence, a variable light chain complementarity determining region 1 (VL CDR1) sequence, a variable light chain complementarity determining region 2 (VL CDR2) sequence, and a variable light chain complementarity determining region 3 (VL CDR3) sequence, wherein the VH CDR1 sequence comprises an amino acid sequence selected from the group consisting of SEQ ID NOs: 67, 73, 78, 88, 95, and 101; the VH CDR2 sequence comprises an amino acid sequence selected from the group consisting of SEQ ID NOs: 68, 74, 79, 89, 96, and 102; the VH CDR3 sequence comprises an amino acid sequence selected from the group consisting of SEQ ID NOs: 69, 80, 90, and 97; the VL CDR1 sequence comprises an amino acid sequence selected from the group consisting of SEQ ID NOs: 70, 81, and 98; the VL CDR2 sequence comprises an amino acid sequence selected from the group consisting of SEQ ID NOs: 71, 82, and 99; and the VL CDR3 sequence comprises an amino acid sequence selected from the group consisting of SEQ ID NOs: 72, 83, 84, 91, 110, 100, and 103.