Patent ID: 9744213
Date: 2017-08-29
CPC Classifications: A61K,A61P,C07K

Claim:
1. A derivative of a FGF21 protein comprising an amino acid sequence, a protractor, and a linker; wherein the amino acid sequence is at least 95% identical to mature human FGF21 (SEQ ID NO:1) and comprises a Cys residue at a position corresponding to position 180 or position 181 of SEQ ID NO:1; wherein the protractor is attached to the Cys residue via the linker; wherein the protractor is selected from the group consisting of HOOC—(CH wherein x is an integer in the range of 8-18; wherein the linker comprises at least one of each of Chem. 2, Chem. 3, and Chem. 4; wherein Chem. 2 is selected from the group consisting of *—NH—CH(COOH)—(CH wherein m is an integer in the range of 1-5; wherein Chem. 3 is *—NH—(CH wherein k is an integer in the range of 1-5 and n is an integer in the range of 1-5; wherein Chem. 4 is *—NH—(CH wherein m is an integer in the range of 1-5; wherein Chem. 2, Chem. 3, and Chem. 4 are interconnected via amide bonds; wherein the linker is (i) connected at its *—NH end to the CO—* end of the protractor and (ii) at its CH