Patent ID: 9732147
Date: 2017-08-15
CPC Classifications: A61K,A61P,C07K

Claim:
1. A method of delivering a polypeptide to the brain of a human across nasal epithelium along olfactory and trigeminal nerve pathways, comprising: a) providing a pharmaceutical composition comprising i) a polypeptide that binds to a melanocortin 4 receptor and comprises an antibody Fc or a mimetibody comprising an antibody Fc fragment and is soluble in the pharmaceutical composition: and ii) from 10 ml to 20 ml of propylene glycol per 100 ml of the pharmaceutical composition; and b) administering the pharmaceutical composition to the nasal cavity of the animal, wherein the polypeptide comprises the amino acid sequence of SEQ ID NO: 1, 2 or 3.