Patent ID: 9637441
Date: 2017-05-02
CPC Classifications: A61K,A61P,C07C,C07D,C07K,C12P,G01N,Y02A,Y02P

Claim:
1. A compound, or salt thereof, comprising Formula (I): wherein: A is optional, and when present is lower alkylene, substituted lower alkylene, lower cycloalkylene, substituted lower cycloalkylene, lower alkenylene, substituted lower alkenylene, alkynylene, lower heteroalkylene, substituted heteroalkylene, lower heterocycloalkylene, substituted lower heterocycloalkylene, arylene, substituted arylene, heteroarylene, substituted heteroarylene, alkarylene, substituted alkarylene, aralkylene, or substituted aralkylene; B is optional, and when present is a linker selected from the group consisting of lower alkylene, substituted lower alkylene, lower alkenylene, substituted lower alkenylene, lower heteroalkylene, substituted lower heteroalkylene, —O—, —S—, —S-(alkylene or substituted alkylene)-, —S(O) J is R is H, alkyl, substituted alkyl, cycloalkyl, or substituted cycloalkyl; each R″ is independently H, alkyl, substituted alkyl, or a protecting group, or when more than one R″ group is present, two R″ optionally form a heterocycloalkyl; R R each of R or the A-B-J-R groups together form a bicyclic or tricyclic cycloalkyl or heterocycloalkyl comprising at least one carbonyl group, including a dicarbonyl group, protected carbonyl group, including a protected dicarbonyl group, or masked carbonyl group, including a masked dicarbonyl group; or the J-R group together forms a monocyclic or bicyclic cycloalkyl or heterocycloalkyl comprising at least one carbonyl group, including a dicarbonyl group; at least one protected carbonyl group, including a protected dicarbonyl group; at least one masked carbonyl group, including a masked dicarbonyl group; or combinations thereof; with a proviso that when A is phenylene and each R 3 is H, B is present; and that when A is —(CH 2 ) 4 — and each R 3 is H, B is not —NHC(O)(CH 2 CH 2 )—; and that when A and B are absent and each R 3 is H, R is not methyl; or an active metabolite, or a pharmaceutically acceptable prodrug or solvate thereof.