Patent ID: 9623093
Date: 2017-04-18
CPC Classifications: A61K,A61P,C07K,C12N,C12Y,G01N

Claim:
1. A pharmaceutical composition, comprising an isolated polynucleotide that encodes an aminoacyl-tRNA synthetase (AARS) polypeptide consisting of a sequence that is at least 95% identical to SEQ ID NO:38, 24, 26, 36, or 40, or a fragment thereof which is 100 or more contiguous amino acids of SEQ ID NO:38, 24, 26, 36, 40, wherein the polynucleotide is selected from (a) a cDNA polynucleotide and (b) a modified mRNA polynucleotide, wherein the AARS polypeptide has an extracellular signalling activity, and wherein the composition is substantially endotoxin free.