Patent ID: 9549994
Date: 2017-01-24
CPC Classifications: A61K,A61P,B82Y,C08B,C08L

Claim:
1. A pharmaceutical composition comprising an aqueous solution comprising an inclusion complex of nicardipine or a pharmaceutically acceptable salt thereof, a buffering agent and a sulfoalkylated β-cyclodextrin, wherein the composition is premixed and is formulated for direct parenteral bolus administration for immediate use without dilution to a human subject, and wherein a pH of the composition is 4.5 to 5.5, wherein the composition is in unit dose format and the unit dose contains the formulation in a volume of from 0.5 to 20 ml, wherein the nicardipine concentration is 0.5 mg/ml, and wherein the sulfoalkylated β-cyclodextrin in the pharmaceutical composition is from 2% to 5% (w/v) wherein the sulfoalkylated β-cyclodextrin is a sulfobutylated β-cyclodextrin having an average of 5 to 8 degrees of sulfobutylation.