Patent ID: 9554564
Date: 2017-01-31
CPC Classifications: A01K,A61D,C12Q

Claim:
1. A mouse whose genome comprises a knockout of an endogenous Pint long non-coding RNA (lncRNA) locus, wherein the knockout results in the mouse exhibiting (a) a premature aging-associated phenotype; (b) a slower growth rate than that of a wild type control; (c) a decline in muscle strength; (d) fibrosis; (e) a lower body fat content than that of the wild type control; (f) a lower femur bone mineral density and bone mass than that of the wild type control; (g) a decreased muscle mass as compared with that of the wild type control; (h) a decrease in median longevity; (i) lordokyphosis; (j) organ atrophy; or (k) a combination of any of (a)-(j).