Patent ID: 9701971
Date: 2017-07-11
CPC Classifications: C12N

Claim:
1. A host cell comprising: (a) a plurality of (n) exogenous donor nucleic acids to be integrated into the host cell genome, wherein: n is at least 2, x is an integer from 1 to n, and for each integer x, each exogenous donor nucleic acid (ES) x comprises a first homology region (HR1) x and a second homology region (HR2) x , wherein (HR1) x and (HR2) x are capable of initiating host cell mediated homologous recombination of (ES) x at a target site (TS) x selected from a plurality of (n) target sites of said host cell genome; and (b) for each said target site (TS) wherein the host cell comprises one or more heterologous nucleotide sequences encoding one or more enzymes of a biosynthetic pathway.