Patent ID: 9624235
Date: 2017-04-18
CPC Classifications: A61K,A61P,C07D,C12Y

Claim:
1. A method of inhibiting AP endonuclease-1/redox factor-1 (hAPE1) activity in a tumor cell resistant to DNA damaging agents comprising application to the tumor cell of a compound having the structure: wherein R 1 is H, a C1-C5 alkyl group, which can be branched, unbranched, cyclic or acyclic, or a 3-5 member ring, which can be homocyclic or heterocyclic; R 2 is H, or a C1-C5 branched, unbranched, cyclic or acyclic alkyl group, and R 3 and R 4 are independently and separately H, a C1-C5 alkyl group, which can be branched, unbranched, cyclic or acyclic, or a 3-5 member ring, which can be homocyclic or heterocyclic.