Patent ID: 9702847
Date: 2017-07-11
CPC Classifications: G01N

Claim:
1. A device for determining a parameter of a substance in a sample, the device comprising: a substrate having an active sensor disposed above the substrate, wherein the active sensor responds to an electrostatic or capacitance change; wherein the active sensor comprises a metal layer and a first electrical component having an electrical characteristic; a functionalized structure comprising a plurality of binding receptors each having at least one cysteine group directly engineered on each of the binding receptors such that the cysteine group on each of the binding receptors secures each of the binding receptors directly to the metal layer of the active sensor and the distance between each of the binding receptors and the metal layer is 5 nm or less, wherein the plurality of binding receptors are configured to bind with the substance to undergo a reaction resulting in the release of ions such that the release of the ions results in a change in the electrical characteristic of the first electrical component independent of current flow in solution; and wherein the first electrical component is configured to generate a signal upon the application of an electrical stimulus, the signal being indicative of the changed electrical characteristic of the first electrical component and wherein the parameter of the substance is determined by the signal indicative of the changed electrical characteristic of the first electrical component.