Patent ID: 9637525
Date: 2017-05-02
CPC Classifications: A61K,A61P,C07K

Claim:
1. A method of inducing an immune response in an individual comprising the steps of administering to the individual an effective amount of a recombinant staphylococcal clumping factor A (ClfA) or fragment thereof comprising at least amino acid residues 221 to 531 of the fibrinogen binding region (Region A), characterized by at least one amino acid residue substitution or deletion at amino acid residue Ala254, Tyr256, Pro336, Tyr338, Ile387, Lys389, Glu526 and/or Val527 to result in a recombinant fibrinogen binding protein with reduced ability or lacking the ability to non-covalently bind fibrinogen; and stimulating a greater antibody immune response than the wild type ClfA protein.