Patent ID: 9701658
Date: 2017-07-11
CPC Classifications: A61K,A61P,C07D

Claim:
1. A compound of the following formula (I): wherein: A is an aryl selected from the group consisting of phenyl, benzoimidazolyl, dihydroisoquinolyl, indolyl, indazolyl, pyrazolyl, pyrazinyl, pyridazinyl, pyridyl, quinolyl, isoquinolyl and thiazolyl; B is selected from the group consisting of a chemical bond, —C W is hydrogen, or C Z is nitrogen atom or CH; R R (1) hydrogen, (2) halogen, (3) hydroxyl, (4) —O n —C 1-6 alkyl, where the alkyl is unsubstituted or substituted with one or more substituents independently selected from R 7 , (5) —O n —C 3-6 cycloalkyl, where the cycloalkyl is unsubstituted or substituted with one or more substituents independently selected from R 7 , (6) —O n —C 2-4 alkenyl, where the alkenyl is unsubstituted or substituted with one or more substituents independently selected from R 7 , (7) —O n -phenyl or —O n — naphthyl, where the phenyl or naphthyl is unsubstituted or substituted with one or more substituents independently selected from R 7 , (8) —O n -heterocyclic group, where the heterocyclic group is unsubstituted or substituted with one or more substituents independently selected from R 7 , (9) —(C═O)—NR 8 R 9 , (10) —NR 8 R 9 , (11) —S(O) 2 —NR 8 R 9 , (12) —NR 8 —S(O) 2 R 9 , (13) —S(O) t —R 9 , where t is 0, 1 or 2, (14) —NR 8 (C═O)R 9 , (15) —CN, and (16) —NO 2 ; wherein n is 0 or 1; when n is 0, a chemical bond is present in the place of —O p is 1, 2, 3, or 4; when p is two or more than two, R R R (1) hydrogen, (2) halogen, (3) —O n —C 1-6 alkyl, where the alkyl is unsubstituted or substituted with one or more substituents independently selected from R 7 , (4) —O n —C 3-6 cycloalkyl, where the cycloalkyl is unsubstituted or substituted with one or more substituents independently selected from R 7 , and (5) —O n —C 2-4 alkenyl, where the alkenyl is unsubstituted or substituted with one or more substituents independently selected from R 7 ; wherein n is 0 or 1; when n is 0, a chemical bond is present in the place of —O n —; q is 1, 2 or 3; when q is two or more than two, R R R (1) hydrogen, (2) halogen, (3) hydroxyl, (4) —(C═O) m —O l —C 1-6 alkyl, where the alkyl is unsubstituted or substituted with one or more substituents independently selected from R 10 , (5) —O l —(C 1-3 )perfluoroalkyl, (6) —(C═O) m —O l —C 3-6 cycloalkyl, where the cycloalkyl is unsubstituted or substituted with one or more substituents independently selected from R 10 , (9) —(C═O) m —O l -heterocyclic group, where the heterocyclic group is unsubstituted or substituted with one or more substituents independently selected from R 10 , and (11) —NR 8 R 9 ; wherein l is 0 or 1 and m is 0 or 1; when l is 0 or m is 0, a chemical bond is present in the place of —O R (1) hydrogen, (2-1) chloro, (2-2) bromo, (2-3) iodo, (3) hydroxyl, (4) —(C═O) m —O l —C 1-6 alkyl, where the alkyl is unsubstituted or substituted with one or more substituents independently selected from R 10 , and (6) —(C═O) m —O l —C 3-6 cycloalkyl, where the cycloalkyl is unsubstituted or substituted with one or more substituents independently selected from R 10 ; wherein l is 0 or 1 and m is 0 or 1; when l is 0 or m is 0, a chemical bond is present in the place of —O R R R (1) hydrogen, (2) hydroxyl, (3) halogen, (4) —C 1-6 alkyl, (5) —C 3-6 cycloalkyl, (6) —O—C 1-6 alkyl, (7) —O(C═O)—C 1-6 alkyl, (8) —NH—C 1-6 alkyl, (9) phenyl, (10) heterocyclic group, and (11) —CN, wherein the heterocyclic group is an unsaturated or saturated mono- or bi-heterocyclic ring which optionally contains 1 to 4 heteroatoms selected from the group consisting of O, N, and S, and wherein the cycloalkyl is a mono- or bicyclic ring selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl and norboranyl; or a pharmaceutically acceptable salt thereof.