Patent ID: 9562087
Date: 2017-02-07
CPC Classifications: A61K,A61P,C07K

Claim:
1. A high affinity programmed cell death 1 (PD-1) mimic polypeptide, comprising an amino acid sequence that is a variant of a human wild-type PD-1 ectodomain sequence, wherein the high affinity PD-1 mimic polypeptide: (a) lacks a wild-type PD-1 transmembrane domain, (b) comprises an amino acid sequence having 85% or more sequence identity to the amino acid sequence set forth in any of SEQ ID NOs: 2-25 and 39-46, and (c) relative to the amino sequence set forth in SEQ ID NO: 2, comprises one or more amino acid changes that cause an increased affinity for human and/or mouse programmed cell death 1 ligand 1 (PD-L1).