Patent ID: 9724279
Date: 2017-08-08
CPC Classifications: A61K,A61P,A61Q,Y02A

Claim:
1. A multilayer core-shell particle, comprising, (a) a functional core; (b) one or more composite shell layers encapsulating the functional core, wherein each composite shell layer comprises, (c) an outermost shell layer, comprising a fourth polymeric layer and a plurality of second di- or trivalent ion-containing nanoparticles, wherein the fourth polymeric layer is made of a third polymer that has the same charge as the first polymer and encapsulates the one or more composite shell layers, while the plurality of second di- or trivalent ion-containing nanoparticles adhere onto the outer surface of the fourth polymeric layer; and (d) a plurality of polymeric tails respectively extending from the outer surface of the outermost shell layer, wherein the plurality of polymeric tails comprise a fourth polymer.