Patent ID: 9561247
Date: 2017-02-07
CPC Classifications: A61K,A61L,A61P

Claim:
1. A method for the revision of a cutaneous keloid or hypertrophic scar, the method comprising: excising at least a portion of the keloid or hypertrophic scar tissue so as to form an excision site; and applying a hydrogel matrix composition to the dermal or subdermal tissue in or around the excision site; wherein the hydrogel matrix composition comprises: gelatin that is soluble in water at 50° C. and has an average molecular mass of about 75,000 Da to about 250,000 Da; and non-derivatized dextran having an average molecular mass of about 10,000 Da to about 1,000,000 Da; wherein the gelatin comprises about 60% by weight to about 95% by weight of the total weight of the combination of the gelatin and the non-derivatized dextran present in the hydrogel matrix composition; wherein the total concentration of the gelatin and the non-derivatized dextran in a hydrated form of the hydrogel matrix composition is about 50 mg/mL to about 400 mg/mL; wherein the hydrated form of the hydrogel matrix composition is phase-controllable so as to be a flowable, injectable liquid at a temperature of 35° C. and greater and is a solid or semi-solid gel matrix at lower temperatures; and wherein the hydrogel matrix composition is not covalently cross-linked before said applying and is not covalently cross-linked after said apply of the hydrogel matrix composition to the dermal or subdermal tissue.