Patent ID: 9732118
Date: 2017-08-15
CPC Classifications: A01K,A61K,A61P,C07K,C12N

Claim:
1. A method of reducing NKT cell activation towards a peptide or a polypeptide in a mammal, the method comprising administering to the mammal an isolated peptide or polypeptide produced by the process of: (a) identifying at least one NKT epitope in an isolated peptide having the sequence of the peptide or polypeptide; and (b) eliminating said at least one NKT cell epitope by deleting at least one hydrophobic amino acid residue in position P1 or P7 of the epitope, or both, or substituting at least one hydrophobic amino acid residue in position P1 or P7, or both, with a non-hydrophobic residue, wherein the NKT cell epitope comprises [F/W/T/H/Y]-X