Patent ID: 9675710
Date: 2017-06-13
CPC Classifications: A61K

Claim:
1. A system for the release of biologically active molecules comprising nanoparticles with an average particle size equal to or less than 1 micron, wherein the nanoparticles have a structure comprising: a lipophilic core comprising at least one solid lipid at room temperature; a hydrophilic phase surrounding the lipophilic core, said hydrophilic phase comprising at least one cationic surfactant and at least one non-ionic surfactant; at least one biologically active molecule, wherein the biologically active molecule is selected from the group consisting of nucleic acids, oligonucleotides, polynucleotides and mixtures thereof; and at least one polysaccharide, wherein the polysaccharide is selected from the group consisting of chitosans, dextrans, hyaluronic acid, carrageenan, chondroitin, keratin, colominic acid, xanthan, cyclodextrins, salts or derivatives of polysaccharides selected from chitosans, dextrans, hyaluronic acid, carrageenan, chondroitin, keratin, colominic acid, xanthan or cyclodextrins, and mixtures thereof; wherein said polysaccharide comprises the bonding of at least three monosaccharides, provided that said polysaccharide is not a lipopolysaccharide, and wherein said polysaccharide is either incorporated in the hydrophilic phase of the nanoparticles or forms a complex together with the biologically active molecule, said complex being adsorbed on the surface of the nanoparticles.