Patent ID: 9695227
Date: 2017-07-04
CPC Classifications: C07K,C12N,G01N

Claim:
1. A nanobody comprising: four framework regions (FR1 to FR4) and three complementary determining regions (CDR1 to CDR3), according to Formula (I) wherein the nanobody specifically binds to a complex comprising a GPCR and a G protein; wherein the nanobody specifically binds to the G protein and not to the GPCR; and wherein CDR1 is SEQ ID NO: 13, CDR2 is SEQ ID NO: 25, and CDR3 is SEQ ID NO: 37; or CDR1 is SEQ ID NO: 14, CDR2 is SEQ ID NO: 26, and CDR3 is SEQ ID NO: 38; or CDR1 is SEQ ID NO: 15, CDR2 is SEQ ID NO: 27, and CDR3 is SEQ ID NO: 39; or CDR1 is SEQ ID NO: 16, CDR2 is SEQ ID NO: 28, and CDR3 is SEQ ID NO: 40; or CDR1 is SEQ ID NO: 17, CDR2 is SEQ ID NO: 29, and CDR3 is SEQ ID NO: 41; or CDR1 is SEQ ID NO: 18, CDR2 is SEQ ID NO: 30, and CDR3 is SEQ ID NO: 42.