Patent ID: 9644008
Date: 2017-05-09
CPC Classifications: A61K,C07K,C12N

Claim:
1. A multivalent influenza virus vaccine, comprising: a deglycosylated hemagglutinin which has an HA1 module and an HA2 module, and the HA1 and HA2 contain a stem region and a head region, and a pharmaceutically acceptable adjuvant or carrier, wherein glycosylation sites of the HA1 and HA2 on the stem region are removed and the deglycosylation site amino acid residues are Asparagine, wherein deglycosylation of glycosylation sites of the HA1 and HA2 results from substitution of Asparagine with Alanine, wherein the hemagglutinin is a hemagglutinin of avian H5N1 influenza virus, wherein the stem region of the hemagglutinin of the avian H5N1 influenza virus comprises amino acids at positions 343 to 527 of the HA2 module, wherein the deglycosylation site comprises an amino acid at position 484 of the HA2 module on the stem region of the hemagglutinin of the avian H5N1 influenza virus.