Patent ID: 9592497
Date: 2017-03-14
CPC Classifications: B01J,C07B

Claim:
1. A process for the mono-reduction of one or more imide moieties in a compound comprising contacting the compound with hydrogen gas and a catalyst comprising a transition metal hydride in the presence or absence of a base, under conditions for the mono-reduction of the one or more imide moieties to form a compound comprising one or more hydroxy amides, wherein mono-reduction comprises a single reduction of one carbonyl functionality of an imide moiety to a hydroxy group to form a hydroxy amide, wherein: (i) said compound comprising one or more imide moieties is a compound of Formula (IX) wherein R 35 and R 36 are joined together to form, including the carbon atoms to which they are attached and the imide nitrogen, an unsubstituted or substituted 5-20-membered monocyclic or polycyclic saturated or unsaturated ring system, wherein the optional substituents are selected from one or more of the group consisting of (C 1-6 )-alkyl, fluoro-substituted (C 1-6 )-alkyl, halo, (C 1-6 )-alkoxy, fluoro-substituted (C 1-6 )-alkoxy, and (C 6-14 )-aryl; and R wherein the compound of Formula (IX) is chiral or achiral; (ii) said compound comprising one or more hydroxy amides is a compound of Formula (Xa) or (Xb) wherein R (iii) said transition metal hydride is a neutral or cationic complex comprising transition metal Ru, Fe, Rh, Ir, Pd, Cu, or Pt, and coordinated thereto: (a) one to four ligands selected from the group consisting of: a bidentate diphosphine (P—P) ligand, and a bidentate diamino (N—N) ligand; (b) one to three hydride ligands; (c) zero to two neutral monodentate ligands; and (d) zero to two anionic monodentate ligands; wherein if the complex is cationic, the complex further comprises one or more suitable counteranions.