Patent ID: 9546154
Date: 2017-01-17
CPC Classifications: A61P,C07D,G01N

Claim:
1. A method for preparing the compound of the formula 1-salt characterized in that dabigatran etexilate of formula 1 is combined with methanesulphonic acid 2 in a suitable solvent, wherein IR-spectroscopic monitoring of the combination process is carried out by means of an IR probe immersed in the reaction medium and wherein up to 99 mol% methanesulfonic acid is added to the dabigitran etexilate in a first addition and the remaining amount of methanesulfonic acid is added continuously or batchwise in a second stage until the formation of the compound of formula 1-disalt is detected by the IR-spectroscopic monitoring of the process and the addition of methanesulfonic acid is stopped.