Patent ID: 9644009
Date: 2017-05-09
CPC Classifications: C07K,C12P

Claim:
1. A method for producing an L-amino acid comprising: A) culturing in a medium a bacterium of the family Enterobacteriaceae which has an ability to produce an L-amino acid and which has been modified to increase the expression of a gene selected from the group consisting of evgA, gadE, ydeO, and combinations thereof, B) producing and accumulating the L-amino acid in the medium, and C) collecting the L-amino acid from the medium, wherein expression of said gene(s) is/are increased by a method selected from the group consisting of: a) increasing the copy number of said gene(s), b) modifying an expression regulatory sequence of said gene(s), c) modifying the bacterium so that the expression of an evgS gene that encodes a sensor kinase is increased by a method selected from the group consisting of: d) combinations thereof, and wherein said L-amino acid is selected from the group consisting of a basic amino acid, a hydroxymonoaminocarboxylic acid, and an aromatic amino acid, wherein the basic amino acid is selected from the group consisting of L-lysine, L-ornithine, L-arginine, L-histidine, and L-citrulline; wherein the hydroxymonoaminocarboxylic acid is selected from the group consisting of L-threonine and L-serine; and wherein the aromatic amino acid is selected from the group consisting of L-tryptophan, L-phenylalanine, and L-tyrosine.