Patent ID: 9566310
Date: 2017-02-14
CPC Classifications: A61K,A61P

Claim:
1. A method for treating a subject with muscular dystrophy, comprising administering an effective amount of an α7β1 integrin modulatory agent to the subject with muscular dystrophy, wherein the α7β1 integrin modulatory agent comprises ciclopirox ethanolamine, deferoxamine, 2,2-dipyridyl; 5α-cholestan-3β-ol-6-one, N032-0003, N066-0070, N069-0071, N069-0075, N064-0028, N066-0053, N069-0073, 1080-0573, an agent having a formula selected from wherein each R 1 and R 2 independently is selected from C 1-10 alkyl, substituted C 1-10 alkyl, C 1-10 alkoxy, substituted C 1-10 alkoxy, acyl, acylamino, acyloxy, acylC 1-10 alkyloxy, amino, substituted amino, aminoacyl, aminocarbonylC 1-10 alkyl, aminocarbonylamino, aminodicarbonylamino, aminocarbonyloxy, aminosulfonyl, C 6-15 aryl, substituted C 6-15 aryl, C 6-15 aryloxy, substituted C 6-15 aryloxy, C 6-15 arylthio, substituted C 6-15 arylthio, carboxyl, carboxyester, (carboxyester)amino, (carboxyester)oxy, cyano, C 3-8 cycloalkyl, substituted C 3-8 cycloalkyl, (C 3-8 cycloalkyl)oxy, substituted (C 3-8 cycloalkyl)oxy, (C 3-8 cycloalkyl)thio, substituted (C 3-8 cycloalkyl)thio, halo, hydroxyl, C 1-10 heteroaryl, substituted C 1-10 heteroaryl, C 1-10 heteroaryloxy, substituted C 1-10 heteroaryloxy, C 1-10 heteroarylthio, substituted C 1-10 heteroarylthio, C 2-10 heterocyclyl, C 2-10 substituted heterocyclyl, C 2-10 heterocyclyloxy, substituted C 2-10 heterocyclyloxy, C 2-10 heterocyclylthio, substituted C 2-10 heterocyclylthio, imino, oxo, sulfonyl, sulfonylamino, thiol, C 1-10 alkylthio, and substituted C 1-10 alkylthio, thiocarbonyl; or two R two R each of A, B, C, D, E, and F independently may be selected from carbon, nitrogen, oxygen, and sulfur; and n may be zero, 1, 2, 3, 4, or 5; or a combination of any of these compounds, wherein the α7β1 integrin modulatory agent increases α7β1 integrin expression or activity as compared to α7β1 integrin expression or activity prior to treatment, thereby treating the subject with muscular dystrophy.