Patent ID: 9655968
Date: 2017-05-23
CPC Classifications: A61K,A61P

Claim:
1. A process for increasing the solubility of baclofen without use of strong acids or strong bases for initial solvation of the baclofen, and without sonication and without intense agitation to dissolve the baclofen, comprising dissolving baclofen in a multivalent physiological ion solution consisting essentially of 130-160 mM NaCl, 2.7-3.9 mM KCl, 1-10 mM CaCl 2 .2H 2 O, 0.5-10 mM MgCl 2 .6H 2 O and a remainder water, wherein a concentration of dissolved baclofen of greater than 2 mg/ml and up to 10 mg/ml in the multivalent physiological ion solution is achieved, producing a baclofen solution for low-volume therapeutic delivery, wherein no visual particulate matter is present in the baclofen solution.