Patent ID: 9585818
Date: 2017-03-07
CPC Classifications: A61K,A61P,A61Q

Claim:
1. An aqueous-free, enamel protectant and enamel repair, toothpaste treatments containing: stannous fluoride and calcium in a substantivity agent selected from emulsions of polymethylsiloxanes in nonionic poloxamer surfactants, wherein: (a) Substantivity of said stannous fluoride and calcium into biofilm present on enamel is enhanced through a shift in calcium binding from bidentate to monodentate in the presence of stannous fluoride; (b) EPF and ERF values of at least 2.5 and 200, respectively, are achieved with periodic administration of said toothpastes onto enamel surfaces with biofilm present; (c) wherein the stannous fluoride is present in an amount of 400-1100 ppm; (d) wherein the composition has a pH of 3-5.8; (e) wherein the calcium content is 0.5-5.0%; (f) wherein the calcium is limited to one or more of calcium fumarate, calcium sulfate, calcium gluconate, and mixed sodium and calcium salts of methyl/vinyl/ether/maleic copolymers thereof; and (g) wherein said nonionic poloxamer is selected from solid and liquid, nonionic poloxamers and combinations thereof.