Patent ID: 9650638
Date: 2017-05-16
CPC Classifications: A61K,A61P,C12N,G01N

Claim:
1. A periostin aptamer that specifically binds to periostin and is in a length of 25 to 100 bases comprising 5 to 20 modified bases that are substituted with a hydrophobic functional group selected from the group consisting of a naphthyl group, a benzyl group, a pyrrole benzyl group, and tryptophan at 5-position of dU (deoxyuracil), wherein the nucleotide sequence of the periostin aptamer is selected from the group consisting of SEQ ID NO: 5 to SEQ ID NO: 40, where n in the nucleotide sequence is a modified base substituted at 5-position of dU (deoxyuracil) with a hydrophobic functional group selected from the group consisting of a naphthyl group, a benzyl group, a pyrrole benzyl group, and tryptophan.