Patent ID: 9604906
Date: 2017-03-28
CPC Classifications: C07B,C07C

Claim:
1. A process for preparing atomoxetine hydrochloride comprising the steps of: a). condensing the compound of formula II with 2-fluorotoluene in the presence of inorganic base in mixture of hydrocarbon and polar aprotic solvent with continuous water removal, wherein the water is formed during the condensation; b). extracting the reaction mixture in an appropriate solvent, wherein the appropriate solvent is a hydrocarbon solvent; c). treating with oxalic acid solution in isopropyl alcohol; d). isolating oxalic acid salt of tomoxetine of formula III; e). basifying compound of formula III in hydrocarbon solvent; f). treating obtained mass without isolating free base with (S)-(+)-mandelic acid in ester solvent; g). isolating (S)-(+)-mandelic acid salt of (R)-tomoxetine of formula IV; h). basifying (S)-(+)-mandelic acid salt of (R)-tomoxetine of formula IV in mixture of water and hydrocarbon solvent; i). separating the layers and distilling the hydrocarbon solvent; j). adding the mixture of ether and nitrile solvents in residue; k). treating with alcoholic hydrochloric acid to form atomoxetine hydrochloride of formula I; and l). purifying atomoxetine hydrochloride of formula I in suitable solvent.