Patent ID: 9732123
Date: 2017-08-15
CPC Classifications: A61K,A61M,A61P,C07K,Y02A

Claim:
1. A vaccine comprising a nucleic acid molecule encoding one or more antigens that induce an immune response against Botulinum toxin, wherein the one or more antigens comprise an amino acid sequence(s) selected from the group consisting of: (a) heavy chain amino acid sequence of Botulinum A serotype neurotoxin (SEQ ID NO: 2); (b) heavy chain amino acid sequence of Botulinum B serotype neurotoxin (SEQ ID NO: 4); (c) heavy chain amino acid sequence of Botulinum E serotype neurotoxin (SEQ ID NO: 6); (d) heavy chain amino acid sequence of Botulinum F serotype neurotoxin (SEQ ID NO: 8); (e) an amino acid sequence that is 96% identical or greater to the heavy chain amino acid sequence of Botulinum A serotype neurotoxin (SEQ ID NO: 2); (f) an amino acid sequence that is 96% identical or greater to the heavy chain amino acid sequence of Botulinum B serotype neurotoxin (SEQ ID NO: 4); (g) an amino acid sequence that is 96% identical or greater to the heavy chain amino acid sequence of Botulinum E serotype neurotoxin (SEQ ID NO: 6); and (h) an amino acid sequence that is 96% identical or greater to the heavy chain amino acid sequence of Botulinum F serotype neurotoxin (SEQ ID NO: 8).