Patent ID: 9579287
Date: 2017-02-28
CPC Classifications: A61K

Claim:
1. A method of repairing tissue comprising implanting into a patient a therapeutically effective amount of a pharmaceutical composition comprising microparticles comprising a biodegradable and biocompatible material having cells of interest adhered to at least a portion of a surface of the microparticles, wherein the biodegradable and biocompatible material comprises an adhesive coating that facilitates adhesion of the cells, and wherein the cells of interest are selected from the group consisting of embryonic cells and stem cells; and at least one substance active on the cells or their environment upon implantation of the microparticles in the patient wherein the substance is released in a controlled or extended manner for at least two weeks after implantation, wherein the substance is a factor acting in cell differentiation and/or a factor promoting the survival of cells, wherein the microparticles have a diameter of about 10 to about 500 μm, and wherein the biodegradable and biocompatible material comprises polyester.