Patent ID: 9630944
Date: 2017-04-25
CPC Classifications: C07D

Claim:
1. Process for the preparation of Imatinib of formula (I) or a salt thereof: comprising: a) reacting of a compound of formula (II): with a compound of formula (III) or a salt thereof: wherein X is hydroxyl, chlorine, bromine or other leaving group, in an organic solvent, to yield the Imatinib of formula (I), b) transferring the Imatinib of formula (I) from an organic phase to an aqueous phase having a pH of between 3.5 and 5.0, c) separating the organic phase and the aqueous phase, and d) isolating the Imatinib or salt thereof, wherein the organic phase contains tetrahydrofuran or methyltetrahydrofuran; and wherein the level of impurity F in the Imatinib is less than 40 ppm.