Patent ID: 9701643
Date: 2017-07-11
CPC Classifications: A61K,A61P,C07D

Claim:
1. A method of inhibiting a JNK1 or JNK2 kinase in a cell expressing said JNK1 or JNK2 kinase, comprising contacting said cell with an effective amount of a compound of formula (I): or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, wherein: R R provided the compound is not 2-(2-aminoethylamino)-4-(methylamino)pyrimidine-5-carboxamide, 2-(2-aminopropylamino)-4-(cyclohexylamino)pyrimidine-5-carboxamide, 2-(2-amino-2-oxoethylamino)-4-(cyclohexylamino)pyrimidine-5-carboxamide, 2-(2-aminoethylamino)-4-(cyclohexylamino)pyrimidine-5-carboxamide, (S)-2-(2-aminopropylamino)-4-(cyclobutylamino)pyrimidine-5-carboxamide, (R)-2-(1-amino-3-methyl-1-oxobutan-2-ylamino)-4-(cyclobutylamino)pyrimidine-5-carboxamide, 4-(cyclopentylamino)-2-(methylamino)pyrimidine-5-carboxamide, or 2-(1-acetylpiperidin-4-ylamino)-4-(cyclopropylamino)pyrimidine-5-carboxamide.