Patent ID: 9724506
Date: 2017-08-08
CPC Classifications: A61N,Y10T

Claim:
1. A method for measuring membrane potentials from a cell using an electrode device, the method comprising: placing an electrode array in contact with cell membrane of the cell such that a nano-scale electrode of the electrode array is engulfed by a portion of the membrane, the electrode array comprising a plurality of nano-scale electrodes that are vertically aligned in the electrode array; recording extracellular signals of the cell using the nano-scale electrode, the extracellular signals indicating at least one action potential of the cell; electroporating, using the nano-scale electrode, the cell to increase the permeability of the portion of the cell membrane engulfing the nano-scale electrode such that intracellular signals of the cell are recorded by the nano-scale electrode in response to the electroporation; and recording the intracellular signals of the cell using the nano-scale electrode, the intracellular signals indicating one or more action potentials of the cell, wherein the electrode device comprising: a substrate patterned with a plurality of metal pads; a plurality of electrode arrays, each electrode array attached to the substrate above a metal pad and electrically connected to the metal pad; and a chamber surrounding the plurality of nano-scale electrodes.