Patent ID: 9679757
Date: 2017-06-13
CPC Classifications: B01D,G01N,H01J

Claim:
1. A liquid chromatography system comprising: a first solvent manager adapted and configured to dispense various ratios of a first solvent and a second solvent; a first HILIC column in fluid communication with and downstream of the first solvent manager; a mixer in fluid communication with and downstream of the first column; a first valve in fluid communication with and downstream of the mixer; a second trapping column having a first end in fluid communication with a first port of the first valve and a second end in fluid communication with a second port of the first valve such that flow between the first port and the second port passes through the second trapping column; a second solvent manager adapted and configured to dispense various ratios of a third solvent and a fourth solvent; and a second valve in fluid communication with and downstream of the second solvent manager, wherein the second valve is in fluid communication with and upstream of the first valve at a first port of the second valve, and wherein the second valve is in fluid communication with and upstream of the mixer at a second port of the second valve; wherein the first valve and the second valve are adapted and configured for actuation between: