Patent ID: 9730483
Date: 2017-08-15
CPC Classifications: A43B,A61K,A61L,A61M,A61P,A61Q,D06M

Claim:
1. A method for obtaining a formulation of hydrophobic topical application microparticles having an active ingredient dispersed therein, wherein the formulation is suitable for application to a living subject; said method comprising: a) forming a formulation comprising a stirred melt of the active ingredient and a non-crosslinked hydrophobic carrier material, wherein the non-crosslinked hydrophobic carrier material is a lipid, a fatty acid-based lipid, a phospholipid, a wax, a fatty acid, a glyceride, a sterol, or any combination thereof; and b) homogenizing the formulation of a) and obtaining microparticles from the homogenized formulation of a), wherein the microparticles have a body, the body comprising a central part and a surface, the central part and the surface including the non-crosslinked hydrophobic carrier material throughout which is uniformly dispersed the active ingredient; wherein the microparticles are responsive to one or more of temperature and pH of the living subject to trigger progressive erosion of the surface and the subsequent progressive erosion of the central part to release the non-crosslinked hydrophobic carrier material and the active ingredient, and wherein the microparticles have all three dimensions in the range of about 0.1 micrometers to about 200 micrometers.