Patent ID: 9683040
Date: 2017-06-20
CPC Classifications: A61K,A61P,C07K

Claim:
1. A monoclonal antibody or an antigen binding fragment thereof that specifically binds to human ROBO4 and comprises a heavy chain and a light chain, wherein: a) said heavy chain comprises SEQ ID NO: 44 (CDRH1), SEQ ID NO: 46 (CDRH2), and SEQ ID NO: 48 (CDRH3) and said light chain comprises SEQ ID NO: 50 (CDRL1), SEQ ID NO: 52 (CDRL2), and SEQ ID NO: 54 (CDRL3); b) said heavy chain comprises SEQ ID NO: 44 (CDRH1), SEQ ID NO: 68 (CDRH2), and SEQ ID NO: 48 (CDRH3) and said light chain comprises SEQ ID NO: 50 (CDRL1), SEQ ID NO: 52 (CDRL2), and SEQ ID NO: 54 (CDRL3); c) said heavy chain comprises SEQ ID NO: 44 (CDRH1), SEQ ID NO: 68 (CDRH2), and SEQ ID NO: 48 (CDRH3) and said light chain comprises SEQ ID NO: 70 (CDRL1), SEQ ID NO: 52 (CDRL2), and SEQ ID NO: 54 (CDRL3); or d) said heavy chain comprises SEQ ID NO: 44 (CDRH1), SEQ ID NO: 46 (CDRH2), and SEQ ID NO: 48 (CDRH3) and said light chain comprises SEQ ID NO: 70 (CDRL1), SEQ ID NO: 52 (CDRL2), and SEQ ID NO: 54 (CDRL3).