Patent ID: 9550071
Date: 2017-01-24
CPC Classifications: A61K,A61N,B82Y

Claim:
1. A method of photo-dynamic therapy comprising the step of: applying ionizing radiation from an external ionizing radiation source and an internal ionizing radiation source to a target site of an animal or human, where the target site includes a cancerous growth and/or tumor, an effective amount of nano-particles, and a photo effective amount of a photosensitizer, where the external ionizing radiation source comprises an x-ray, a gamma ray source, a neutron source, an x-ray microbeam source, an electron source, a proton source, or an ion beam source producing ionizing radiation selected from the group consisting of gamma rays or x-rays having a frequency range between about 1 keV to 50,000 keV, electrons, protons, or neutrons, where the internal ionizing radiation source comprises an effective amount of radioactive seeds present in the target site that produce gamma rays having a frequency range between about 1 keV to 50,000 keV, where the ionizing radiation from both radiation sources generates energetic electrons within the site in a cathodoluminescence process, the nano-particles absorb a portion of the energetic electrons, the nano-particles convert a portion of energy from the absorbed energetic electrons into photons having a frequency range corresponding to an absorption frequency range of the photosensitizer, and the photosensitizer absorbs a portion of the photons activating oxygen to form oxygen radicals capable of producing a localized photodynamic therapeutic affect reducing a number of cancer cells or reducing a size of the tumor.