Patent ID: 9718867
Date: 2017-08-01
CPC Classifications: A61P,C07K

Claim:
1. A GDF-5 related protein, having an improved capability of inducing cartilage formation or a reduced capability of inducing bone formation, wherein the protein has an increased affinity for the BMP receptor IB (BMPR-IB) and/or a reduced affinity for the BMP receptor IA (BMPR-IA) and wherein, referring to the full-length amino acid sequence of wild-type GDF 5 protein, one or more of the following amino acids, or one or more amino acids at corresponding positions in a different GDF-5 related protein are replaced by the specified amino acid: R399 is replaced by M or E; W414 is replaced by R; W417 is replaced by R or F; R438 is replaced by K; S439 is replaced by K or E; I449 is replaced by V.