Patent ID: 9550790
Date: 2017-01-24
CPC Classifications: A61K,A61P,C07D,C07F,C07K

Claim:
1. A compound of Formula VIII or IX produced by a process compromising reacting a compound of Formula I (a)with a halomethylester of the formula: Hal-Rc wherein Hal is a halogen and Rc is a hydrolysable linker of the formula Q R5 is CH Z1 and Z2 are independently S or O; R6 is hydrogen optionally substituted aliphatic, optionally substituted aryl, alkoxy, carboxy, amino, heterocycle, aryloxy, and optionally substituted therewith a targeting agent (T) to from R6-T; wherein M is O; R1 is selected from H, F, Cl, Br, I, alkenyl, alkynyl, carbocycle, aryl, heterocycle, heteroaryl, formyl, nitro, cyano, amino, carboxylic acid, carboxylic ester, carboxyl amide, reverse carboxyamide, substituted alkyl, substituted alkenyl, substituted alkynyl, substituted carbocycle, substituted aryl, substituted heterocycle, substituted heteroaryl, phosphonic acid, phosphinic acid, phosphoramidate, phosphonic ester, phosphinic ester, ketone, substituted ketone, hydroxamic acid, N-substituted hydroxamic acid, O-substituted hydroxamate, N- and O-substituted hydroxamate, sulfoxide, substituted sulfoxide, sulfone, substituted sulfone, sulfonic acid,sulfonic ester, sulfonamide, N-substituted sulfonamide, N,N-disubstituted sulfonamide, boronic acid, boronic ester, azo, substituted azo, azido, nitroso, imino, substituted imino, oxime, substituted oxime, alkoxy, substituted alkoxy, aryloxy, substituted aryloxy, thioether, substituted thioether, carbamate, substituted carbamate; R2 is Where X is N; n is 1; Y is O; R R3 is selected from R1; R4 is selected from R1; Cyc is selected from aryl, substituted aryl, heterocycle, substituted heterocycle, carbocycle, and substituted carbocycle and (b) when R6 is substituted with a targeting agent (T) to form R6-T, R6-T is selected from: wherein T is selected from a carbohydrate, vitamin, peptide, protein, nucleoside, nucleotide, nucleic acid, liposome, lipid, bone-seeking agent, and cartilage seeking agent.