Patent ID: 9611328
Date: 2017-04-04
CPC Classifications: A61P,C07K

Claim:
1. A method for treating cancer, comprising administering a therapeutically effective amount of an isolated antibody comprising a modified Fc-containing molecule comprising a wild type human IgG1 Fc region of SEQ ID NO: 1 comprising a hinge, a CH2 domain and a CH3 domain, wherein a) the sequence of E233-L234-L235-G236 in the hinge is replaced with P233-V234-A235 with G236 deleted; and b) the CH2 domain comprises at least one substitution selected from the group consisting of S239D/1332E, K326A/E333A, H268F/S324T/1332E, F243L/R292P/Y300L, S239D/H268F/S324T/1332E, S267E/H268F/S324T/1332E, K326A/1332E/E333A, S239D/K326A/E333A, S267E/1332E and G237X/S239D/1332E where X is A, D, P, Q or S; wherein amino acid residues are numbered according to EU numbering to a patient in need thereof to treat the cancer.