Patent ID: 9737621
Date: 2017-08-22
CPC Classifications: A61K,A61L,Y10T

Claim:
1. A hydrophobic thermoplastic copolymer, comprising: a first monomer unit, and a second monomer unit on which is grafted a paramagnetic-ion-chelating ligand that optionally complexes with a paramagnetic ion or a paramagnetic-ion-chelating ligand complexed with the paramagneticion, wherein the second monomer unit is grafted in sufficient amount for the copolymer to be visible in magnetic resonance imaging when the second monomer unit is complexed with the paramagneticion, wherein the copolymer has a degree of functionalization of from 0.01 to less than 10%, wherein the copolymer is obtained by copolymerization of the first monomer unit and the second monomer unit, wherein the grafting is provided by amidation, esterification or click chemistry and, said click chemistry giving a linkage function selected from the group consisting of triazole, tetrazole, carbamate, urea, thioether, ether, oxime and thiocarbamate and wherein the copolymer, when the grafting is provided by click chemistry and gives a triazole linkage, is obtained from one selected from the group consisting of: a random copolymer of caprolactone (CL) and propargyl caprolactone (CL-propargyl or Pr-CL), a block copolymer of caprolactone (CL) and propargyl caprolactone (CL-propargyl or Pr-CL), a random copolymer of caprolactone (CL) and 5-NH3 +-δ-valerolactone (5-NH3 +-δ-VL), a block copolymer of caprolactone (CL) and 5-NH3 +-δ-valerolactone (5-NH3 +-δ-VL) and a copolymer of polymethyl acrylate or polymethylmethacrylate and propargyl acrylate.