Patent ID: 9575036
Date: 2017-02-21
CPC Classifications: A61K,A61Q,C08B,G01N,Y10T

Claim:
1. A method of determining free hydrophobic active in an aqueous formulation, comprising: encapsulating a hydrophobic active in the aqueous formulation, wherein the encapsulating comprises the formation of an aqueous dispersion selected from the group consisting of polyurethane dispersions, polyurea dispersions, melamine-formaldehyde dispersions, and urea-formaldehyde dispersions; adding a cyclodextrin to the aqueous formulation, thereby entraining any free hydrophobic active; centrifuging the aqueous formulation to obtain a fraction containing cyclodextrin and entrained hydrophobic active; removing the fraction containing cyclodextrin and entrained hydrophobic active; and quantifying the amount of hydrophobic active entrained in the cyclodextrin.