Patent ID: 9708402
Date: 2017-07-18
CPC Classifications: A61P,C07K

Claim:
1. An anti-BAFF-anti-IL-17 bispecific antibody comprising a first polypeptide and a second polypeptide, wherein the first polypeptide comprises HCVR1, a heavy chain constant region (CH), a first linker (L1), HCVR2, a second linker (L2), and LCVR2, wherein the HCVR1, CH, L1, HCVR2, L2, and LCVR2 are arranged from amino-terminus to carboxyl-terminus in the following order: HCVR1, CH, L1, HCVR2, L2, and LCVR2, and wherein the second polypeptide comprises LCVR1 and a light chain constant region (CL), wherein the LCVR1 is at the amino-terminus and the CL is at the carboxyl-terminus, and wherein HCVR1 comprises amino acids 1-123 of SEQ ID NO:1, HCVR2 comprises amino acids 464-582 of SEQ ID NO:1, LCVR2 comprises amino acids 603-714 of SEQ ID NO:1, and LCVR1 comprises amino acids 1-107 of SEQ ID NO:2.