Patent ID: 9675673
Date: 2017-06-13
CPC Classifications: A61K,A61M,A61P,C12N

Claim:
1. A method for treating cancer tissue in an organ, said method comprising delivering an oncolytic virus selected for susceptibility of infecting the cancer tissue to be treated, locally to the cancer tissue in the organ by application of the virus proximally through an infusion lumen of a balloon catheter inserted into a blood vessel or duct in direct fluid communication with a target site of the cancer tissue, and discharging the virus under relatively low pressure distally from the infusion lumen directly into the blood vessel or duct proximally of the site and distally of a single balloon of the catheter; while selectively increasing pressure in the blood vessel or duct by the concentration or volume of virus delivered, to force the virus under an effective extravasation pressure through a natural endothelial barrier of the blood vessel or duct lining and into the cancer tissue at the target site, thereby increasing local delivery of an effective dose of the virus to the target site of the cancer tissue.