Patent ID: 9545379
Date: 2017-01-17
CPC Classifications: A61K,B01J,B65D,F26B

Claim:
1. A method of producing spray dried formulated plasma, the method comprising: a) providing i) plasma, ii) one or more physiologically compatible spray dry stable acidic substance (SDSAS), wherein said one or more SDSAS is selected from the group consisting of ascorbic acid, citric acid, gluconic acid, glycine hydrogen chloride (glycine-HCl), lactic acid and monosodium citrate, and iii) a spray drying system comprising a spray drier; b) treating the plasma by adjusting the pH of the plasma with the SDSAS by bringing the concentration of the SDSAS to between about 0.001 and about 0.050 mmol/mL in the plasma to create formulated plasma; c) drying the formulated plasma with the spray dryer to create spray dried formulated plasma, and determining that the spray dried formulated plasma has a recovery of von Willebrand factor activity at least 5 percentage points greater than the recovery of von Willebrand factor activity obtained from an otherwise identical spray dried plasma that has not undergone treatment with a SDSAS.