Patent ID: 9695262
Date: 2017-07-04
CPC Classifications: A61K,A61P,B82Y,C07K,C08F,G01N,Y10T

Claim:
1. A composition of matter, comprising a molecularly imprinted polymer (MIP) nanoparticle having binding affinity for an atrial natriuretic peptide comprising amino acid sequence SLRRSSCFGGRMDRIGAQSGLGCNSFRY (SEQ ID NO: 3), wherein the MIP nanoparticle comprises; (i) methacrylic acid (MAA), N-isopropylacrylamide (NIPAm), and N, N′-methylenebisacrylamide (BIS) in a molar ratio of MMA:NIPAm:BIS of 1:3:10, and (ii) an imprint that possesses steric and chemical memory for amino acid sequence SLRRSS (SEQ ID NO: 2) of the atrial natriuretic peptide, and wherein the MIP nanoparticle selectively binds to SEQ ID NO: 2 of the atrial natriuretic peptide comprising amino acid SEQ ID NO: 3.