Patent ID: 9675595
Date: 2017-06-13
CPC Classifications: A61K,A61P

Claim:
1. A method for treating a proliferative disease selected from the group consisting of a colorectal cancer having at least one of a BRAF mutation, KRAS mutation, and PIK3CA mutation and not having a PTEN mutation; a pancreatic cancer having a KRAS mutation; a non-small cell lung cancer having a KRAS mutation; and a melanoma not having a PTEN mutation, comprising the simultaneous, separate or sequential administration of a therapeutically effective amount of the PI3K inhibitor compound (S)-pyrrolidine-1,2-dicarboxylic acid 2-amide 1-({4-methyl-5-[2-(2,2,2-trifluoro-1,1-dimethyl-ethyl)-pyridin-4-yl]-thiazol-2-yl}-amide) or a pharmaceutically acceptable salt thereof, in combination with the MEK inhibitor compound 6 (4 bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethoxy)-amide or a pharmaceutically acceptable salt thereof, to a patient in need thereof having said proliferative disease.