Patent ID: 9532955
Date: 2017-01-03
CPC Classifications: A61K

Claim:
1. A method, comprising: delivering to a mucus membrane a composition comprising a plurality of coated particles, wherein the coated particle comprises: wherein the pharmaceutical agent or salt thereof constitutes at least 95 wt % of the core particle; and a coating comprising a surface-altering agent surrounding the core particle, wherein the surface-altering agent comprises a triblock copolymer comprising a hydrophilic block-hydrophobic block-hydrophilic block configuration, wherein the hydrophobic block has a molecular weight of at least 2 kDa, and the hydrophilic blocks constitute at least 15 wt % of the triblock copolymer, wherein the hydrophobic block associates with the surface of the core particle, wherein the hydrophilic block is present at the surface of the coated particle and renders the coated particle hydrophilic, and wherein the surface-altering agent is present on the surface of the core particle at a density of at least 0.001 molecules per nanometer squared; and wherein the coated particles have a relative velocity of greater than 0.5 in mucus.