Patent ID: 9718856
Date: 2017-08-01
CPC Classifications: A61P,C07K

Claim:
1. A method for preparing a concentrate of human polyvalent immunoglobulins from an initial solution of blood plasma or a fraction of plasma enriched with immunoglobulins, comprising: (a) removing protein contaminants by contacting the initial solution of blood plasma or a fraction of plasma enriched with immunoglobulins with caprylic acid in order to obtain a solution free of proteases, wherein the concentration of caprylic acid ranges from 0.5 to 1.5% by volume of caprylic acid per volume of initial solution of blood plasma or a fraction of plasma enriched with immunoglobulins to be treated, and (b) fluidized bed chromatography of the mixed-mode type of the solution free of proteases, to obtain a concentrate of human polyvalent immunoglobulins with a yield of more than 4.5 g of immunoglobulins per liter of blood plasma.