Patent ID: 9731048
Date: 2017-08-15
CPC Classifications: A61C,A61K,A61L,B82Y,C01G,C07K,G01N

Claim:
1. An isolated peptide comprising a titanium oxide binding amino acid sequence connected to a heterologous biologically active amino acid sequence via a beta sheet breaker linker, wherein: (i) said titanium oxide binding amino acid sequence is selected to bind coordinatively with titanium oxide; (ii) said titanium oxide binding amino acid sequence is selected to induce a beta sheet structure; (iii) said titanium oxide binding amino acid sequence binds to titanium oxide with a higher affinity than said biologically active amino acid sequence binds to said titanium oxide under physiological conditions; and (iv) said titanium oxide binding amino acid sequence comprises the sequence Z-X-Z-X, wherein X is any hydrophobic amino acid and Z is phosphoserine or L-DOPA.