Patent ID: 9717775
Date: 2017-08-01
CPC Classifications: A61K,A61P,G01N

Claim:
1. A method for treating or preventing conditions or disorders associated with the α9α10 subtype of the nicotinic acetylcholine receptor (nAChR) in an individual which comprises administering to an individual in need thereof a therapeutically effective amount of an active agent or a pharmaceutically acceptable salt thereof, wherein the active agent blocks the α9α10 subtype of the nAChR, wherein the active agent is selected from the group consisting of: α-conotoxin PeIA (SEQ ID NO:3), an analog of α-conotoxin Vc1.1 (SEQ ID NO:2), the analog of Vc1.1 being at least one selected from the group consisting of Glu14iodo-His Vc1.1; Glu14iodo-Tyr Vc1.1; Glu14iodo-Trp Vc1.1; Glu14iodo-Phe Vc1.1; an addition to the C-terminus of the preceding analogs; an addition to the N-terminus of the preceding analogs; additions to the C-terminus and N-terminus of the preceding analogs; and replacement of Gly1 in Vc1.1; and an analog of α-conotoxin PeIA (SEQ ID NO:3), the analog of PeIA being at least one selected from the group consisting of Glu14iodo-His PeIA; Glu14iodo-Tyr PeIA; Glu14iodo-Trp PeIA; Glu14iodo-Phe PeIA; an addition to the C-terminus of PeIA or the preceding analogs; an addition to the N-terminus of PeIA or the preceding analogs; additions to the C-terminus and N-terminus of PeIA or the preceding analogs; and replacement of Gly1 in PeIA.