Patent ID: 9737480
Date: 2017-08-22
CPC Classifications: A61K,C07K,G01N

Claim:
1. An arrestin domain-containing protein 1 (ARRDC1)-mediated microvesicle (ARMM), comprising (a) a lipid bilayer, (b) an ARRDC1 protein or fragment thereof, and (c) an agent selected from the group consisting of recombinant nucleic acids, recombinant proteins, and synthetic small molecules, wherein the agent is covalently bound to the ARRDC1 protein or fragment thereof, wherein the microvesicle further comprises an integrin, a receptor tyrosine kinase, a G-protein coupled receptor, a membrane-bound immunoglobulin, or a protein selected from the group consisting of AHCYL2, AIP, AKR7L, AP1B1, AP1M2, C8orf30A, CASK, CNNM4, CPM, CSNK1A1, CSNK1A1L, CSNK2A1, CXADR, EFCAB4B, EIF4B, ENAH, EPB41L5, ERBB2IP, EXOC1, EXOC2, EXOC7, EXOC8, FAM102A, FAM83F, FAM84B, FERMT2, FNBP1L, GALNT7, GRB7, GRB7, ILK-2, INPP5A, IP:IPI00328587.4, IP:IPI00719051.3, ITCH, KIAA0174, KIAA1244, KIAA1522, KIAA1598, KIF13B, LASP1, LNPEP, LRRC1, LSS, MAPK3, MARK2, MLPH, MON2, MTOR, MTSS1, MYO10, MYO18A, NF2, NOTCH2, OCLN, PARVA, PIK3R2, PKM2, PPCS, PPID, PRKAG1, PSMC3, PTPRD, PVRL2, QARS, RAD23B, RHPN2, SH3GL1, SNTB2, SPAG1, SPINT1, SRM, STARD10, STUB1, STX16, SYTL1, TLN2, TNS3, TRIM3, TUBB2C, TWF1, USP5, VAV2, VAV3, XPOT, YARS, ZDHHC5, and ZYX.