Patent ID: 9744124
Date: 2017-08-29
CPC Classifications: A61K

Claim:
1. A flowable composition for delivering a therapeutic agent at or near a target tissue site beneath the skin of a patient, the flowable composition comprising (i) a solvent; (ii) an effective amount of the therapeutic agent; and (iii) a polymer, the flowable composition being capable of hardening to form a drug depot at a physiological temperature or as solvent contacts bodily fluid at or near the target tissue site, wherein the drug depot has a pre-dosed modulus of elasticity of about 2×10 4 to about 2×10 5 dynes/cm 2 , and is capable of releasing the therapeutic agent over a period of at least one day and the target tissue site comprises at least one muscle, ligament, tendon, cartilage, spinal disc, spinal foraminal space near the spinal nerve root, facet or synovial joint, or spinal canal, and the solvent comprises polyethylene glycol with pendant hydroxyl groups (PEGH), the polymer comprises (poly(d,l-lactide-co-glycolide), and the drug depot comprises a porosity of about 25-85%, and the flowable composition is disposed in a deployable balloon.