Patent ID: 9556262
Date: 2017-01-31
CPC Classifications: A61P,C07K,C12N,G01N

Claim:
1. A method of determining the presence of a K11-linked polyubiquitin or K11-linked polyubiquitinated protein in a sample suspected of containing a K11-linked polyubiquitin or K11-linked polyubiquitinated protein, comprising exposing the sample to an antibody that binds K11-linked polyubiquitin and determining the binding of the at least one antibody to a polyubiquitin or polyubiquitinated protein in the sample, wherein: the antibody comprises an HVR-L1 sequence selected from SEQ ID NOs: 2 and 57 to 60, an HVR-L2 sequence selected from SEQ ID NOs: 3 and 61, an HVR-L3 sequence of SEQ ID NO: 4, an HVR-H1 sequence selected from SEQ ID NOs: 6 to 11, an HVR-H2 sequence selected from SEQ ID NOs: 12 to 17 and 67, and an HVR-H3 sequence selected from SEQ ID NOs: 18 to 23, 68 and 69.