Patent ID: 9598356
Date: 2017-03-21
CPC Classifications: C07B,C07C

Claim:
1. An improved process for the manufacture of R-(+)-2-(4-(4-cyano-2-fluorophenoxy)phenoxy)propionic acid alkali metal salt of formula which comprises: a) forming a di (alkali metal salt) of R-(+)-2-(4-hydroxyphenoxy)-propionic acid by contacting R-(+)-2-(4-hydroxyphenoxy)propionic acid in a polar aprotic solvent, having a dipole moment of at least 2 or dielectric constant of at least 7 and having a normal boiling point of less than 175° C., with at least two equivalents of alkali metal carbonate; and b) forming R-(+)-2-(4-(4-cyano-2-fluorophenoxy)-phenoxy)propionic acid alkali metal salt by coupling the di (alkali metal salt) of R-(+)-2-(4-hydroxy-phenoxy)propionic acid reaction mixture of step a) with 3,4-di-fluorobenzonitrile in the presence of a phase-transfer catalyst at a temperature from about 120° C. to about 150° C. in a sealed pressure vessel.