Patent ID: 9625448
Date: 2017-04-18
CPC Classifications: C07C,G01N

Claim:
1. A composition comprising a double-caged GABA compound comprising gamma-amino butyric acid covalently linked to a first photosensitive protecting group linked to a carboxyl of the gamma-amino butyric acid and a second photosensitive protecting group linked to an amine of the gamma-amino butyric acid, wherein the first and second photosensitive protecting groups are independently selected from the group consisting of: nitrobenzyl (NB), nitrophenyl ethyl (NPE), α-carboxy-2-nitrobenyzl (CNB), 4,5-dimethoxy-2-nitrobenzyl (DMNB), (4,5-dimethoxy-2-nitrophenyl)ethyl (DMNPE), 4-methoxy-7-nitroindoline (MNI), 4-carboxymethoxy-5,7-dinitroindolinyl (CDNI), 6-bromo-7-hydroxycoumarin-4-ylmethoxycarbonyl (Bhc), ruthenium-bipyridine-triphenylphosphine (RuBi), and carboxynitrobenzyl, and the double-caged GABA compound is biologically inert before exposure to light, and the first photosensitive protecting group and the second photosensitive protecting group cleave from the gamma-amino butyric acid by photolysis upon exposure of the double-caged GABA compound to light.