Patent ID: 9579383
Date: 2017-02-28
CPC Classifications: A61K,A61P

Claim:
1. An oral dosage form for release of a polar agent therefrom in the duodenum, said oral dosage form comprising a composition having an enteric- or pH-sensitive coating or layer surrounding same, said composition comprising: a therapeutically effective amount of a polar agent having at least one group that confers a degree of partial or permanent charge on the polar agent that is greater than or equal to the charge of an hydroxyl group, a carboxyl group, an imidazole group, an amino group, a guanidino group, a phosphate group, or a sulfate group, and a permeability-enhancing amount of a permeability enhancer comprising glycerol, wherein the permeability enhancer is present in the composition at a concentration from 5% to 95% of the combined weight of the polar agent and the permeability enhancer; and wherein the permeability enhancer promotes paracellular or transcellular transport such that the amount of the polar agent transported across a Caco-2 cell membrane by said oral dosage form is increased by at least 150% relative to the amount transported across the Caco-2 Cell membrane in the absence of the permeability enhancer.