Patent ID: 9594042
Date: 2017-03-14
CPC Classifications: C12Q,G01N

Claim:
1. A method for determining the amount an amount of a factor Xa inhibitor in a blood sample comprising: (a) contacting a blood sample with a dried reagent comprising a known amount of factor X, an activator reagent that induces the conversion of factor X into factor Xa, and a detection reagent comprising a peptidic thrombin substrate that can be cleaved by thrombin and comprising a carboxyl end that is amidically bound to an electrogenic substance, wherein the reagent comprising factor X is added to the sample in a common step with the addition of the activator reagent to the sample; (b) measuring the amount or activity of the electrogenic substance that is cleaved from the thrombin substrate by measuring an electrochemical signal associated with the amount or activity of the electrogenic substance; (c) relating the amount or activity of the electrogenic substance to the amount of Xa inhibitor in the sample, thereby determining the amount of the factor Xa inhibitor in the sample.