Patent ID: 9744178
Date: 2017-08-29
CPC Classifications: A61K,A61P,Y10S

Claim:
1. A process for making a dry powder formulation of respirable agglomerate particles, the process comprising the steps of: (a) preparing a first feedstock comprising a hydrophobic excipient dispersed in an aqueous liquid phase and spray-drying said first feedstock to provide a bulk powder composition comprising a plurality of small porous powder carrier particles; (b) providing at least a first active drug ingredient to having a size of at least 50% having a geometric diameter of less than 3 microns; (c) preparing a second feedstock comprising a suspension of the carrier particles of step (a) and the drug particles of step (b) in a non-aqueous anti-solvent; and (d) subjecting the second feedstock to a solvent removal process to yield a bulk powder formulation comprising an ordered mixture of respirable aggregate particles comprising small porous carrier particles and micronized drug particles, wherein the respirable agglomerate particles are characterized by a tapped density of 0.03 to 0.5 g/cm