Patent ID: 9604995
Date: 2017-03-28
CPC Classifications: C07C,C07D

Claim:
1. A process for the preparation of olanzapine pamoate monohydrate, comprising the following steps: (i) preparing an aqueous solution of olanzapine, or a polymorph or solvate thereof, in the presence of an acid; (ii) preparing an aqueous solution of pamoic acid in the presence of a base; (iii) mixing the aqueous solution of pamoic acid prepared in step (ii) with the aqueous solution of olanzapine prepared in step (i); (iv) stirring the aqueous mixture formed in step (iii) to induce precipitation; (v) optionally, isolating the precipitate formed in step (iv) by filtration; and (vi) drying the precipitate formed in step (iv) to obtain olanzapine pamoate monohydrate.