Patent ID: 9707288
Date: 2017-07-18
CPC Classifications: A61K,A61P,C07K,C12N

Claim:
1. A method for inducing an antibody response against a Group 1 or Group 2 influenza virus in a human subject comprising: (a) administering a first hemagglutinin (HA) protein to the human subject; and (b) administering a second HA protein to the human subject 3-52 weeks after (a); wherein the first and second HA proteins comprise heads that are antigenically unrelated to each other and to seasonal influenza but comprise conserved antigenic sites in the stem; wherein the stem is a Group 1 stem if the antibody response is against a Group 1 influenza virus or the stem is a Group 2 stem if the antibody response is against a Group 2 influenza virus; and wherein the Group 1 or Group 2 influenza virus to which an antibody response is induced comprises a head that is antigenically unrelated to the first and second HA proteins and to seasonal influenza but comprises the conserved antigenic sites in the stem of the first and second HA protein.