Patent ID: 9617344
Date: 2017-04-11
CPC Classifications: A61K,A61P,C07K

Claim:
1. A fusion protein comprising a targeting moiety, a cleavage site, and a cell membrane penetrating domain, wherein the targeting moiety is an antibody or antigen-binding fragment thereof, a designed ankyrin repeat protein (DARPin), or a combination thereof, that specifically binds an ErbB family receptor tyrosine kinase protein; the cleavage site is a recognition site of a matrix metalloproteinase (MMP), cathepsin, or urokinase-type plasminogen activator (uPA); and the cell membrane penetrating domain is a membrane-translocation sequence, a macromolecule intracellular transduction domain, a fusion peptide comprising a hydrophobic peptide and a basic peptide, or a combination thereof.