Patent ID: 9677133
Date: 2017-06-13
CPC Classifications: B01L,C12Q,G01N

Claim:
1. A biological chip hybridization system, comprising: a bio-chip, which comprises a substrate with probe array and a cover plate with at least two through holes, wherein a hybridization chamber is formed between the substrate and the cover plate; at least two fluid channels, which are connected to the hybridization chamber respectively through said two through holes; and a fluid control device, which is connected to the fluid channel, wherein the bio-chip further comprises a microfluidic layer disposed between the cover plate and the substrate, wherein the microfluidic layer has the hybridization chamber and at least two hollow-out microfluidic channels, with one end of each microfluidic channel connected to the hybridization chamber, and the other end connected to one through hole of the cover plate, respectively, and the hybridization chamber of the microfluidic layer connected to the bio-probe array of the substrate, wherein the surface of the cover plate contacted with the microfluidic layer has a contact angle of less than 90 degrees with respect to water, and the other surface of the cover plate has a contact angle of 90 to 180 degrees with respect to water.