Patent ID: 9744246
Date: 2017-08-29
CPC Classifications: A61K,A61P,C08G

Claim:
1. A macromolecule comprising: i) a dendrimer comprising a core and at least one generation of building units, the outermost generation of building units having surface amino groups wherein at least two different terminal groups are covalently attached to the surface amino groups of the dendrimer; ii) a first terminal group which is a residue of a pharmaceutically active agent comprising a hydroxyl group; iii) a second terminal group which is a pharmacokinetic modifying agent; wherein the first terminal group is covalently attached to the surface amino group of the dendrimer through a diacid linker, the diacid linker comprising an alkyl chain interrupted by one or more oxygen, sulfur or nitrogen atoms, or an aryl, cycloalkyl, heterocyclic or heteroaryl group; wherein the diacid linker forms an ester bond with the hydroxyl group of the pharmaceutically active agent and an amide bond with the surface amino group; or a pharmaceutically acceptable salt thereof.