Patent ID: 9616102
Date: 2017-04-11
CPC Classifications: A61K,A61P,G01N

Claim:
1. A method for causing inhibition of Kv1.3 potassium channels in a human or animal subject, said method comprising administering to the subject, in a form and amount that is effective to inhibit Kv1.3 potassium channels, a composition of matter comprising ShK toxin polypeptide attached to an organic chemical entity that has an anionic charge, wherein said chemical entity is covalently attached to the N-terminus of the ShK polypeptide through a 5-aminoethyloxyethyloxyacetic acid (AEEAc) linker, and wherein said chemical entity is selected from the group consisting of L-Tyr (PO 3 H 2 ) and p-Phosphono-Phenylalanine (ppa).