Patent ID: 9643984
Date: 2017-05-09
CPC Classifications: C07D,Y02P

Claim:
1. A method comprising; subjecting (R)—N′-(3-fluoro-5-(1methyl-1H-pyrazol-4-yl)pyridin-2-yl)-2-(3-(2-methoxyethoxy)-5-oxo-1,6-naphthyridin-6(5H)yl)propanehydrazide (“HYDZ”): to a dehydration reaction with either a thiophosphetane compound or a phosphorus (V) dehydrating agent thereby forming (R)-6-(1-(8-fluoro-6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)ethyl)-3-(2-methoxyethoxy)-1,6-naphthyridin-5(6H)-one (“A”):