Patent ID: 9593161
Date: 2017-03-14
CPC Classifications: A61K,A61P,C07K

Claim:
1. An immunobinder comprising: (i) light chain CDR1, CDR2 and CDR3 from a donor lagomorph immunobinder and heavy chain CDR1, CDR2 and CDR3 from a donor lagomorph immunobinder; (ii) a variable human light chain framework; and (iii) a variable human heavy chain framework that is at least 85% identical to the sequence of SEQ ID NO: 4 and comprises a threonine (T) at position 24, alanine (A) or glycine (G) at position 56, threonine (T) or asparagine (N) at position 84, and leucine (L) or valine (V) at position 89 (AHo numbering).