Patent ID: 9572883
Date: 2017-02-21
CPC Classifications: A61K,A61P,C12N

Claim:
1. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and an isolated oncolytic recombinant rhabdovirus encoding a G protein sequence selected from the group consisting of (i) the Isfahan virus G protein sequence as set forth in SEQ ID NO: 26, (ii) the Maraba virus G protein sequence as set forth in SEQ ID NO: 5, (iii) the Muir Springs virus G protein sequence as set forth in SEQ ID NO: 21, (iv) a G protein having an amino acid sequence at least 96% identical to SEQ ID NO: 26, (v) a G protein having an amino acid sequence at least 96% identical to SEQ ID NO: 5 and (vi) a G protein having an amino acid sequence at least 96% identical to SEQ ID NO: 21; the rhabdovirus further encoding M, P, N and L proteins from vesicular stomatitis virus (VSV).