Patent ID: 9707535
Date: 2017-07-18
CPC Classifications: B01J,B01L,C07H

Claim:
1. An apparatus for synthesizing a molecule, comprising: a reaction substrate having at least one reaction chamber and at least one microfluidic channel for transferring a reagent to the reaction chamber; a reagent cassette coupled to the substrate, the reagent cassette having at least one reagent port for transferring the reagent from the cassette to the microfluidic channel; a power supply configured to apply a voltage differential, wherein the voltage differential is sufficient for generating an electroosmotic force to cause the reagent to flow from the cassette through the microfluidic channel; a paramagnetic solid support in contact with an interior wall of the reaction chamber, the paramagnetic solid support attached to a material for reacting with the reagent in the reaction chamber; a magnet positioned to hold the paramagnetic solid support in contact with the interior wall of the reaction chamber by a magnetic field generated by the magnet while the reagent is flowing through the reaction chamber; a first optical fiber passing through the reaction substrate; and a second optical fiber passing through the reaction substrate, wherein the first optical fiber and the second optical fiber are positioned on opposite sides of the reaction chamber such that an optical path passes from the first optical fiber through the reaction chamber to the second optical fiber for permitting real-time optical spectroscopy of at least one product within the reaction chamber, wherein each of the first optical fiber and the second optical fiber are separated from the reaction chamber by a section of the reaction substrate wherein the optical path is perpendicular to a direction of flow of the reagent in the reaction chamber.