Patent ID: 9708405
Date: 2017-07-18
CPC Classifications: A61K,A61P,C07H,C07K,C12N

Claim:
1. An isolated antibody, or an antigen binding fragment thereof, that binds to chemokine receptor 4 (CXCR4) and comprises: a) a heavy chain variable (VH) region comprising (i) a VH CDR1 selected from the group consisting of SEQ ID NOs:107, 113 and 114; (ii) a VH CDR2 selected from the group consisting of SEQ ID NOs: 162 and 128; and (iii) a VH CDR3 set forth as SEQ ID NO: 112; and b) a light chain variable region (VL) region comprising (i) a VL CDR1 set forth as SEQ ID NO: 144; (ii) a VL CDR2 set forth as SEQ ID NO: 145; and (iii) a VL CDR3 set forth as SEQ ID NO: 139.