Patent ID: 9649323
Date: 2017-05-16
CPC Classifications: A61K,A61P

Claim:
1. A method for treating a tumor in a subject, comprising (a) administering a therapeutically effective dose of liposome encapsulating a photosensitizer and an anti-tumor drug to a subject, wherein the liposome comprises a lipid bilayer comprising phospholipids and an aqueous interior, (b) performing a first irradiation to the tumor tissues at the time the liposome reaches the tumors, (c) performing a second irradiation to the tumor tissues at the time the anti-tumor drug released from the liposome accumulates at the tumor tissues to a maximum amount, and optionally (d) performing third or more irradiations to the tumor tissues; wherein the photosensitizer is 2-[7S8S)-3Carboxy-7-(2-carboxyethyl)-13-ethenyl-18-ethyl-7.8-dihydro-2,8,12,17-tetramethyl-21H,23H-porphin-5-yl]acetic acid (chlorin e6; Ce6) and the anti-tumor drug is cis-platin, wherein Ce6 is encapsulated within the lipid bilayer and cis-platin is encapsulated within the aqueous interior, and wherein the tumor is colon and rectal cancer, lung cancer, cervical cancer, oral cancer or malignant peripheral nerve sheath tumor.