Patent ID: 9663575
Date: 2017-05-30
CPC Classifications: A61K,A61P,C07K

Claim:
1. A method of alleviating a symptom of a cancer or other neoplastic condition, the method comprising administering an isolated monoclonal antibody or an immunologically active fragment thereof that binds to human CD47 to a subject in need thereof in an amount sufficient to alleviate the symptom of the cancer or other neoplastic condition in the subject, wherein the antibody or immunologically active fragment thereof comprises: a variable heavy (VH) chain CDR1 amino acid sequence set forth in SEQ ID NO: 50, SEQ ID NO: 57, SEQ ID NO: 58, SEQ ID NO: 59, SEQ ID NO: 60, SEQ ID NO: 61, SEQ ID NO: 62, SEQ ID NO: 63, SEQ ID NO: 64, SEQ ID NO: 65, or SEQ ID NO: 66; a VH chain CDR2 amino acid sequence set forth in SEQ ID NO: 51, SEQ ID NO: 72, SEQ ID NO: 73, SEQ ID NO: 74, SEQ ID NO: 75, or SEQ ID NO: 76; a VH chain CDR3 amino acid sequence set forth in SEQ ID NO: 52 or SEQ ID NO: 77; a variable light (VL) chain CDR1 amino acid sequence set forth in SEQ ID NO: 53, SEQ ID NO: 67, or SEQ ID NO: 68; a VL chain CDR2 amino acid sequence set forth in SEQ ID NO: 54, SEQ ID NO: 69, SEQ ID NO: 70, or SEQ ID NO: 71; and a VL chain CDR3 sequence set forth in SEQ ID NO: 55.