Patent ID: 9689880
Date: 2017-06-27
CPC Classifications: G01N,G16H,Y02A

Claim:
1. A method for treating an asymptomatic cardiovascular subject or a previously undiagnosed cardiovascular subject determine to be at risk for a future arteriovascular event or disease comprising: providing a blood sample isolated from an asymptomatic cardiovascular subject or a previously undiagnosed cardiovascular subject; measuring at least four component ARTERIORISKMARKERS in the blood sample selected from one or more groups consisting of Core Markers I, Core Markers II, Traditional Laboratory Risk Factors, Supplemental Markers I, Supplemental Markers II, Additional Markers I, and Additional Markers II, wherein at least one component ARTERIORISKMARKER is adiponectin; calculating an index value from an output of a Support Vector Machine (SVM) model, wherein inputs to the model comprise the measurements, and further wherein the model was developed by fitting data from a longitudinal study of a selected population of individuals and the fitted data comprises levels of the biomarkers and an end point in the selected population of individuals, wherein a calculated area under the curve (AUC) of the model is greater than or equal to 0.70, and wherein the end point is the risk of the cardiovascular event or the cardiovascular event; and administering to the subject a therapeutic or prophylactic agent.