Patent ID: 9629892
Date: 2017-04-25
CPC Classifications: A61K,A61P,C07K,C12N,C12Y,G01N

Claim:
1. A method of treating or effecting prophylaxis of a damaging effect of penetrative ballistic injury to the CNS, comprising administering to a subject having or at statistically significant risk of penetrative ballistic injury to the CNS relative to the general population a pharmacological agent that inhibits binding of PSD-95 to an NMDAR and/or of PSD-95 to nNOS at a dose of 0.1 to 10 mg/kg and the administering inhibits development of cognitive deficits in the subject, wherein the pharmacological agent comprises a peptide having an amino acid sequence comprising T/SXV/L linked to an internalization peptide.