Patent ID: 9624262
Date: 2017-04-18
CPC Classifications: A61K,C07K

Claim:
1. A process for separating at least fibrinogen and immunoglobulin G from a sample of blood plasma, comprising the steps of: a) providing a sample of blood plasma in a container; b) adding a polyacid and a salt comprising ≦50 mM sodium chloride and at least one additional salt to the blood plasma, whereby said blood plasma comprises 50-100 mmol/L of total salt at pH between 6 and 8, causing formation of a first protein precipitate that comprises a majority of the fibrinogen in said sample and recovering said first protein precipitate and a first supernatant separately; and c) adding an additional amount of a polyacid to said first supernatant, causing formation of a second protein precipitate that comprises a majority of the immunoglobulin G in said sample and a second supernatant and recovering said second protein precipitate separately, wherein the polyacid is added in an amount to give a total polyacid concentration in said first supernatant which is 5-8%; wherein said first protein precipitate comprises a concentrate of the first protein and said second protein precipitate comprises a concentrate of the second protein.