Patent ID: 9688749
Date: 2017-06-27
CPC Classifications: A61K,A61P,C07K

Claim:
1. A method of treatment of chronic pain in a subject comprising administering to the subject an effective amount of an anti-NGF antibody capable of inhibiting binding NGF and TrkA to treat chronic pain in said subject, wherein (a) the variable region of the antibody light chain comprises three complementarity determining regions (CDRs) having the sequences of from amino acid 24 to amino acid 34 of SEQ ID NO. 1; from amino acid 50 to amino acid 56 of SEQ ID NO. 1; and from amino acid 89 to amino acid 97 of SEQ ID NO. 1; and (b) the variable region of the antibody heavy chain comprises three of the complementarity determining regions (CDRs) having the sequences of amino acid 26 to amino acid 35 of SEQ ID NO. 2; from amino acid 50 to amino acid 65 of SEQ ID NO. 2; and from amino acid 98 to amino acid 111 of SEQ ID NO. 2.