Patent ID: 9702866
Date: 2017-07-11
CPC Classifications: G01N

Claim:
1. A method to determine the relative potency of a batch of glatiramer acetate (GA) comprising stimulating human monocytic cell line cells with an effective amount of interferon gamma (IFNγ), contacting said cells with a dose of GA, determining the expression of the monocyte anti-inflammatory cytokine, secreted form of IL-1 receptor antagonist (sIL-1 Ra), and determining said relative potency by comparing a batch of GA with a reference batch of GA, and wherein parallel dose response curves for said expression of the monocyte anti-inflammatory cytokine sIL-1Ra, for the batch of GA and the reference batch of GA, determines the relative potency of said batch of GA compared with the potency of said reference batch of GA.