Patent ID: 9745584
Date: 2017-08-29
CPC Classifications: A61K,A61P,C12N,C12Q,Y02A

Claim:
1. A synthetic, modified oligonucleotide of 15 to 30 nucleotides in length comprising at least one modification wherein the at least one modification is selected from: at least one modified sugar moiety; at least one modified internucleotide linkage; at least one modified nucleotide, and combinations thereof; wherein said oligonucleotide is an antisense compound which is 100% complementary to and specifically hybridizes to a complementary region of a natural antisense polynucleotide of a PAR4 gene wherein said natural antisense comprises SEQ ID NO: 2 and upregulates the function and/or expression of a PAR4 gene in vivo or in vitro as compared to a normal control.