Patent ID: 9688728
Date: 2017-06-27
CPC Classifications: A61K,A61P,C07K,C12N

Claim:
1. A fusion protein comprising an amyloid binding fragment of g3p and an Fc fragment of an immunoglobulin, wherein the protein comprises: (a) amino acids 21-506 of SEQ ID NO:9; (b) amino acids 22-506 of SEQ ID NO:9; (c) amino acids 23-506 of SEQ ID NO:9; (d) amino acids 21-505 of SEQ ID NO:9; (e) amino acids 22-505 of SEQ ID NO:9; (f) amino acids 23-505 of SEQ ID NO:9; (g) amino acids 21-506 of SEQ ID NO:11; (h) amino acids 22-506 of SEQ ID NO:11; (i) amino acids 23-506 of SEQ ID NO:11; (j) amino acids 21-505 of SEQ ID NO:11; (k) amino acids 22-505 of SEQ ID NO:11; (l) amino acids 23-505 of SEQ ID NO:11; (m) amino acids 21-509 of SEQ ID NO:13; (n) amino acids 22-509 of SEQ ID NO:13; (o) amino acids 23-509 of SEQ ID NO:13; (p) amino acids 21-508 of SEQ ID NO:13; (q) amino acids 22-508 of SEQ ID NO:13; (r) amino acids 23-508 of SEQ ID NO:13; (s) amino acids 21-528 of SEQ ID NO:31; (t) amino acids 22-528 of SEQ ID NO:31; (u) amino acids 23-528 of SEQ ID NO:31; (v) amino acids 21-527 of SEQ ID NO:31; (w) amino acids 22-527 of SEQ ID NO:31; (x) amino acids 23-527 of SEQ ID NO:31; or (y) a mutant or variant that is at least 95% identical to the amino acid sequence of any one of (a)-(x) and is capable of binding to amyloid.