Patent ID: 9708403
Date: 2017-07-18
CPC Classifications: A61P,C07K

Claim:
1. A method of producing a monoclonal antibody or antigen-binding fragment thereof, comprising expressing an isolated nucleic acid or isolated nucleic acids in an isolated host cell, which isolated nucleic acid or nucleic acids separately or in combination encode a monoclonal antibody or antigen-binding fragment thereof that binds to an extracellular portion of an inhibitory human Killer IgG-like Receptor 2DL polypeptide KIR2DL1, KIR2DL2 and/or KIR2DL3, wherein the monoclonal antibody or antigen-binding fragment thereof: (i) reduces KIR2DL1, KIR2DL2 and/or KIR2DL3-mediated inhibition of NK cell cytotoxicity, and (ii) does not detectably reduce binding between said KIR2DL1, KIR2DL2 and/or KIR2DL3 and an HLA class I ligand of said KIR2DL1, KIR2DL2 and/or KIR2DL3.