Patent ID: 9555091
Date: 2017-01-31
CPC Classifications: A61K,A61P,C12N

Claim:
1. A method for inducing an immune response against a specific antigen in a mammalian subject in need thereof, comprising: (a) transfecting into an insect cell a recombinant bacmid comprising (i) a nucleotide sequence encoding an envelope protein of an endogenous retrovirus; (ii) a first promoter that is operable in the insect cell and is operatively linked to (i); (iii) a nucleotide sequence encoding a second antigen protein not from any baculovirus and endogenous retrovirus; and (iv) a second promoter that is from a mammalian genome or virus, which is different the first promoter and is operatively linked to (iii); (b) obtaining a recombinant baculovirus vector produced from the insect cell, wherein the recombinant baculovirus vector is an endogenous retrovirus envelope-coated Baculovirus vector to express the second antigen; and (c) administering a pharmaceutically effective amount of the recombinant baculovirus of (b) to the mammalian subject.