Patent ID: 9671391
Date: 2017-06-06
CPC Classifications: C07K,G01N

Claim:
1. A method for determining whether or not an agent is a candidate agent for inhibiting interaction between interleukin-34 (IL-34) and protein tyrosine phosphatase receptor type zeta (PTP-ζ) comprising: contacting cells that express PTP-ζ on their surface and that do not express colony stimulating factor-1 receptor (CSF-1R) with IL-34 in the presence of the agent and in the absence of the agent, and measuring a cellular response induced by IL-34, wherein an agent that reduces a cellular response induced by IL-34 is a candidate agent for inhibiting interaction between IL-34 and PTP-ζ, and wherein an agent that does not reduce a cellular response induced by IL-34 is not a candidate agent for inhibiting interaction between IL-34 and PTP-ζ.