Patent ID: 9617307
Date: 2017-04-11
CPC Classifications: A61K,A61P,A61Q,C07K

Claim:
1. A method for reinforcing the cornified envelopes in the stratum corneum of the epidermis by establishing covalent bonds between peptides belonging to the family of late cornified envelope (LCE) proteins and said cornified envelopes, under the action of endogenous transglutaminases, comprising the administration of an effective amount of at least one polypeptide to a subject in need thereof, said polypeptide belonging to the family of late proteins of the cornified envelope (LCE), said polypeptide being a fragment of the sequence SEQ ID NO: 2, said fragments having a length of 15 amino acids or less and of at least 5 consecutive amino acids within SEQ ID NO: 2 and having at least one glutamine (Gln)-lysine (Lys) domain within said at least 5 consecutive amino acids.