Patent ID: 9737544
Date: 2017-08-22
CPC Classifications: A61K,A61P,C07D

Claim:
1. A method for treating a subject suffering from, or being at risk of suffering from cancer, said method comprising administering to the subject a compound selected from the group consisting of a compound of formula (I-A) or (I-B) a tautomeric form, stereochemically isomeric form and isotopic form thereof, wherein for (I-A) X X X for (I-B) X each R D represents a 3 to 12 ring membered monocyclic or bicyclic carbocyclyl or a 3 to 12 ring membered monocyclic or bicyclic heterocyclyl containing at least one heteroatom selected from N, O or S, wherein said carbocyclyl and heterocyclyl may each be optionally substituted by one or more R R R C R for a compound of formula (I-A), R wherein ring A is a monocyclic 5 to 7 membered saturated heterocycle containing one heteroatom selected from N, O or S, said heteroatom not being positioned in alpha position of the double bond, wherein ring A is optionally being substituted with cyano, C 1-4 alkyl, hydroxyC 1-4 alkyl, H 2 N—C 1-4 alkyl, (C 1-4 alkyl)NH—C 1-4 alkyl, (C 1-4 alkyl) 2 N—C 1-4 alkyl, (haloC R R R —NH—S(═O) R R R C or when two of the substituents of R R R R —C(═O)—C R R n independently represents an integer equal to 0, 1, 2, 3 or 4; or an N-oxide thereof, a pharmaceutically acceptable salt thereof or a solvate thereof.