Patent ID: 9598484
Date: 2017-03-21
CPC Classifications: A61K,A61P,C07K,G01N

Claim:
1. A polynucleotide linked to a heterologous nucleic acid, wherein the polynucleotide is selected from the group consisting of: (a) a polynucleotide encoding an immunoglobulin heavy chain or a fragment thereof comprising a heavy chain variable region (VH) comprising complementarity determining regions (CDRs) 1, 2, and 3 with the amino acid sequences set forth in SEQ ID NOs:85, 86, and 87, respectively, wherein the VH when paired with a light chain variable region (VL) comprising the amino acid sequence set forth in SEQ ID NO:49 binds to tau; (b) a polynucleotide encoding an immunoglobulin heavy chain or a fragment thereof comprising a VH comprising CDRs 1, 2, and 3 with the amino acid sequences set forth in SEQ ID NOs:103, 104, and 105, respectively, wherein the VH when paired with a VL comprising the amino acid sequence set forth in SEQ ID NO:55 binds to tau; (c) a polynucleotide encoding an immunoglobulin light chain or a fragment thereof comprising a VL comprising CDRs 1, 2, and 3 with the amino acid sequences set forth in SEQ ID NOs:88, 89, and 90, respectively, wherein the VL when paired with a VH comprising the amino acid sequence set forth in SEQ ID NO:48 binds to tau; (d) a polynucleotide encoding an immunoglobulin light chain or a fragment thereof comprising a VL comprising CDRs 1, 2, and 3 with the amino acid sequences set forth in SEQ ID NOs:106, 107, and 108, respectively, wherein the VL when paired with a VH comprising the amino acid sequence set forth in SEQ ID NO:54 binds to tau; (e) a polynucleotide encoding (i) an immunoglobulin heavy chain or a fragment thereof comprising a VH comprising CDRs 1, 2, and 3 with the amino acid sequences set forth in SEQ ID NOs:85, 86, and 87, respectively; and (ii) an immunoglobulin light chain or a fragment thereof comprising a VL comprising CDRs 1, 2, and 3 with the amino acid sequences set forth in SEQ ID NOs:88, 89, and 90, respectively, wherein the VH when paired with the VL binds to tau; (f) a polynucleotide encoding (i) an immunoglobulin heavy chain or a fragment thereof comprising a VH comprising CDRs 1, 2, and 3 with the amino acid sequences set forth in SEQ ID NOs:103, 104, and 105, respectively; and (ii) an immunoglobulin light chain or a fragment thereof comprising a VL comprising CDRs 1, 2, and 3 with the amino acid sequences set forth in SEQ ID NOs:106, 107, and 108, respectively, wherein the VH when paired with the VL binds to tau; (g) a polynucleotide encoding an immunoglobulin heavy chain or a fragment thereof comprising a VH comprising the amino acid sequence set forth in SEQ ID NO:48, wherein the VH when paired with a VL comprising the amino acid sequence set forth in SEQ ID NO:49 binds to tau; (h) a polynucleotide encoding an immunoglobulin heavy chain or a fragment thereof comprising a VH comprising the amino acid sequence set forth in SEQ ID NO:47, wherein the VH when paired with a VL comprising the amino acid sequence set forth in SEQ ID NO:49 binds to tau; (i) a polynucleotide encoding an immunoglobulin light chain or a fragment thereof comprising a VL comprising the amino acid sequence set forth in SEQ ID NO:49, wherein the VL when paired with a VH comprising the amino acid sequence set forth in SEQ ID NO:48 binds to tau; (j) a polynucleotide encoding an immunoglobulin heavy chain or a fragment thereof comprising a VH comprising the amino acid sequence set forth in SEQ ID NO:54, wherein the VH when paired with a VL comprising the amino acid sequence set forth in SEQ ID NO:55 binds to tau; (k) a polynucleotide encoding an immunoglobulin heavy chain or a fragment thereof comprising a VH comprising the amino acid sequence set forth in SEQ ID NO:220, wherein the VH when paired with a VL comprising the amino acid sequence set forth in SEQ ID NO:55 binds to tau; (l) a polynucleotide encoding an immunoglobulin light chain or a fragment thereof comprising a VL comprising the amino acid sequence set forth in SEQ ID NO:55, wherein the VL when paired with a VH comprising the amino acid sequence set forth in SEQ ID NO:54 binds to tau; (m) a polynucleotide encoding an immunoglobulin heavy chain or a fragment thereof comprising a VH comprising the amino acid sequence set forth in SEQ ID NO:48 and an immunoglobulin light chain or a fragment thereof comprising a VL comprising the amino acid sequence set forth in SEQ ID NO:49; (n) a polynucleotide encoding an immunoglobulin heavy chain or a fragment thereof comprising a VH comprising the amino acid sequence set forth in SEQ ID NO:47 and an immunoglobulin light chain or a fragment thereof comprising a VL comprising the amino acid sequence set forth in SEQ ID NO:49; (o) a polynucleotide encoding an immunoglobulin heavy chain or a fragment thereof comprising a VH comprising the amino acid sequence set forth in SEQ ID NO:54 and an immunoglobulin light chain or a fragment thereof comprising a VL comprising the amino acid sequence set forth in SEQ ID NO:55; (p) a polynucleotide encoding an immunoglobulin heavy chain or a fragment thereof comprising a VH comprising the amino acid sequence set forth in SEQ ID NO:220 and an immunoglobulin light chain or a fragment thereof comprising a VL comprising the amino acid sequence set forth in SEQ ID NO:55; (q) a polynucleotide encoding an immunoglobulin heavy chain comprising the amino acid sequence set forth in SEQ ID NO:218; (r) a polynucleotide encoding an immunoglobulin light chain comprising the amino acid sequence set forth in SEQ ID NO:219; and (s) a polynucleotide encoding an immunoglobulin heavy chain comprising the amino acid sequence set forth in SEQ ID NO:218 and an immunoglobulin light chain comprising the amino acid sequence set forth in SEQ ID NO:219.