Patent ID: 9580489
Date: 2017-02-28
CPC Classifications: A61K,A61M,A61P,C07K

Claim:
1. A formulation comprising: (a) 1-100 mg/mL of a VEGF-specific fusion protein antagonist; (b) 5-40 mM of a buffer; (c) 0.01-5% of an organic co-solvent; and (d) a stabilizer or 30-150 mM of a tonicity agent, wherein the VEGF-specific fusion protein antagonist represents at least 90% of the total weight of protein in the composition, at least 90% of the total weight of the VEGF-specific fusion protein antagonist is not present as an aggregate, and the VEGF-specific fusion protein antagonist comprises an Ig domain 2 of human VEGF receptor 1, an Ig domain 3 of human VEGF receptor 2, and a multimerizing component.