Patent ID: 9688993
Date: 2017-06-27
CPC Classifications: A61K,C12N

Claim:
1. A method for inhibiting a TLR9-mediated immune response in a mammal, the method comprising administering an effective amount of a compound to inhibit the TLR-mediated immune response, wherein the compound comprises the sequence 5′-G x TC*G*(N 1 ) m CC*G*CAG x (N 2 ) p -3 ′ (SEQ ID NO: 3), wherein Gx is 2′-deoxyguanosine or 2′-deoxyguanosine methylphosphonate, N 1 is any nucleotide and N 2 is any nucleotide, wherein m is 10 and p is 0 or 1, and wherein C* is a nucleotide comprising a nitrogenous base selected from the group consisting of cytosine, 5-methyl-2′-deoxycytosine and 2′-O-methylcytosine and G* is a nucleotide comprising a nitrogenous base selected from the group consisting of guanine, 5-methyl-2′deoxyguanosine and 2′-O-methylguanine, provided that at least one of the nucleotides C* or G* comprises a methylated nitrogenous base; and provided that at each instance that N 1 comprises a CG dinucleotide C is a nucleotide comprising a nitrogenous base selected from the group consisting of cytosine, 5-methyl-2′-deoxycytosine and 2′-O-methylcytosine and G is a nucleotide comprising a nitrogenous base selected from the group consisting of guanine, 5-methyl-2′-deoxyguanosine and 2′-O-methylguanine, provided that at least one of the nucleotides C or G comprises a methylated nitrogenous base; or the complementary sequence thereto.