Patent ID: 9592304
Date: 2017-03-14
CPC Classifications: A61K,A61P,C07K

Claim:
1. A recombinant immunoconjugate comprising a Pseudomonas exotoxin (PE) toxin covalently linked to a recombinant disulfide-stabilized Fv (dsFv) anti-CD22 antibody, wherein the recombinant immunoconjugate comprises a Pseudomonas exotoxin PE38 covalently linked at its amino terminus to an RFB4 disulfide-stabilized Fv (dsFv) having a variable heavy chain (V H ) comprising SEQ ID NO:2 in which a Cys residue is substituted for Arg at position 44; and a variable light chain (V L ) comprising SEQ ID NO:4 in which a Cys residue is substituted for Gly at position 100.