Patent ID: 9663456
Date: 2017-05-30
CPC Classifications: A61P,C07C

Claim:
1. A process for preparation of 3-[(1R,2R)-3-(dimethylamino)-1-ethyl-2-methylpropyl]phenol of Formula-I and its pharmaceutically acceptable salts, wherein the process comprises: a) reacting (2S,3R)-1-(dimethylamino)-3-(3-methoxyphenyl)-2-methylpentan-3-ol of Formula-III  with isocyanate of Formula-IV,  wherein R is selected from C b) hydrogenating the compound of Formula II to compound of Formula V, c) subjecting the compound of Formula V to demethylation to give compound of Formula I, d) optionally, converting the compound of Formula I to its pharmaceutically acceptable salts.