Patent ID: 9717723
Date: 2017-08-01
CPC Classifications: A61K,A61P,C07H,Y10S

Claim:
1. A method of preparing a liposomal irinotecan composition, the method comprising contacting, in an aqueous medium, a liposome comprising sucrose octasulfate and a substituted ammonium compound encapsulated within an aqueous interior space separated from the aqueous medium by a membrane comprised of one or more lipids; with an irinotecan cationic antineoplastic agent; wherein the substituted ammonium is a compound of formula: R 1 —(R 2 —)N + (—R 3 )—R 4 , wherein N is a an ammonium nitrogen atom, each of R wherein the contacting is carried out for a time sufficient for the irinotecan antineoplastic agent to become encapsulated within the liposome as irinotecan sucrose octasulfate.