Patent ID: 9657099
Date: 2017-05-23
CPC Classifications: A61K,A61P,C07K

Claim:
1. An isolated antibody or antigen-binding fragment thereof that specifically binds to glucagon (GCG) and neutralizes GCG activity, wherein the antibody or antigen-binding fragment thereof comprises: (a) three heavy chain complementarity determining regions (HCDR1, HCDR2 and HCDR3) contained within a heavy chain variable region (HCVR) amino acid sequence selected from the group consisting of SEQ ID NOs: 2, 18, 34, 50, 66, 82, 98, 114, 130 and 146; and (b) three light chain CDRs (LCDR1, LCDR2 and LCDR3) contained within a light chain variable region (LCVR) amino acid sequence selected from the group consisting of SEQ ID NOs: 10, 26, 42, 58, 74, 90, 106, 122, 138 and 154.