Patent ID: 9618522
Date: 2017-04-11
CPC Classifications: C12Q,G01N

Claim:
1. A method of diagnosing a frontotemporal lobar degeneration subtype comprising measuring total Tau and Tau phosphorylated at threonine 181 in a cerebrospinal fluid sample from a subject, calculating the ratio of Tau phosphorylated at threonine 181 to total Tau, recording the calculated ratio, and making a diagnosis of the subtype based on the calculated ratio, wherein the frontotemporal lobar degeneration subtypes are selected from frontotemporal lobar degeneration with immunoreactive lesions to Tau and frontotemporal lobar degeneration with immunoreactive lesions to TAR DNA binding protein of 43 kD, and wherein the cerebrospinal fluid is vortexed for 15 seconds immediately before measuring total Tau and Tau phosphorylated at threonine 181.