Patent ID: 9540432
Date: 2017-01-10
CPC Classifications: A61K,A61P,C07K,G01N

Claim:
1. An antibody selected from the group consisting of an isolated antibody, a monoclonal antibody and a recombinant antibody, wherein (a) said antibody has a binding affinity to an Aβ(20-42) globulomer that is greater than the binding affinity of the antibody to an Aβ(1-42) globulomer; (b) the binding affinity of the antibody to the Aβ(20-42) globulomer is at least 10 times greater than the binding affinity of the antibody to the Aβ(1-42) globulomer; (c) the antibody is humanized and binds to the same epitope as a monoclonal antibody 7C6 obtainable from a hybridoma designated by American Type Culture Collection deposit number PTA-7240; (d) the antibody comprises (i) a VH 7C6 CDR1 consisting of amino acid residues 31-35 of SEQ ID NO: 11, (ii) a VH 7C6 CDR2 consisting of amino acid residues 50-65 of SEQ ID NO: 11, (iii) a VH 7C6 CDR3 consisting of amino acid residues 98-107 of SEQ ID NO:11, (iv) a VL 7C6 CDR1 consisting of amino acid residues 24-39 of SEQ ID NO: 12, (v) a VL 7C6 CDR2 consisting of amino acid residues 55-61 of SEQ ID NO: 12, and (vi) a VL 7C6 CDR3 consisting of amino acid residues 94-102 of SEQ ID NO:12.