Patent ID: 9713589
Date: 2017-07-25
CPC Classifications: A61K,A61P

Claim:
1. Method for reducing the percentage of aggregate formation in atomized material of immunoglobulin single variable domains, comprising atomizing in a vibrating-mesh nebulizer a composition comprising an aqueous carrier and a polypeptide comprising one or more immunoglobulin single variable domains, wherein: the concentration of the polypeptide comprising one or more immunoglobulin single variable domains present in the composition is 50 mg/mL or more; wherein the aqueous carrier comprises phosphate, TRIS or citrate buffer at pH 5.5-7.5, and the percentage of aggregate formation in the atomized material, as determined by SE-HPLC, is reduced compared to the percentage of aggregate formation in atomized material obtained from a composition of immunoglobulin single variable domains at a concentration of 5 mg/mL or atomized in a jet nebulizer.