Patent ID: 9562016
Date: 2017-02-07
CPC Classifications: A61K,A61P,C07B,C07D,C30B

Claim:
1. Crystallized 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide (Compound A): prepared according to a process comprising the steps of: a) dissolving Compound A in a solution comprising (i.) a solvent system comprising an ether and optionally an alcohol, and (ii.) water to provide a solution; b) adding a seed crystal suspension to the solution to provide a suspension mixture; c) cooling the suspension mixture to provide a cooled suspension mixture; d) adding water to the cooled suspension mixture to provide a treated mixture; and e) cooling the treated mixture, to provide the crystallized 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide.