Patent ID: 9593335
Date: 2017-03-14
CPC Classifications: A61P,C12N,C12Y

Claim:
1. A siRNA with a double-stranded structure, the double-stranded structure consisting of a first single strand and a second single strand which are completely complementary, wherein, the first single strand has a nucleotide sequence represented by SEQ ID NO: 77, which is the same as a target site sequence in a plk1 mRNA sequence represented by SEQ ID NO: 1; and the second single strand complementary to the first single strand has a nucleotide sequence represented by SEQ ID NO: 209, which is complementary to the target site sequence in the plk1 mRNA sequence represented by SEQ ID NO: 1, wherein each of the first single strand and the second single strand contains at least one modified nucleotide group respectively, wherein the modified nucleotide group is a nucleotide group in which the 2′-hydroxy of the ribose group is substituted by methoxy or fluorine, wherein the siRNA is selected from the following: PLK(m)-76-1 in which the first single strand is C(OMe)GAGCU(OMe)GCUUAAUG(OMe)ACGAGdTdT (SEC) ID NO: 278); and the second single strand is CU(OMe)CGUC(F)AUUAAGCAGCUCGdTdT (SEC) ID NO: 279), wherein (OMe) means that the 2′-hydroxy of the pentose group in the nucleotide residue on its left is substituted by methoxy, while (F) means that the 2′-hydroxy of the pentose group in the nucleotide residue on its left is substituted by fluorine.