Patent ID: 9745359
Date: 2017-08-29
CPC Classifications: A61K,A61P,C07K

Claim:
1. A fusion protein obtained by linking an interleukin-1 receptor antagonist protein or an analogue thereof with another polypeptide which is a GLP-1 receptor binding polypeptide or an analogue thereof, wherein the sequence of said fusion protein is: wherein X X L X the structure of general formula 1 is in which J is the structure of L M L the structure of -W—X-Y—Z wherein W is an α-amino acid residue having a carboxyl group in the side chain, this residue forms, with one of its carboxyl groups, an amide group together with the amino group at the end of L or W is a chain composed of two, three or four α-amino acids linked together via amide bonds, this chain is linked via an amide bond to the amino group at the end of L or W is a covalent bond from X to the amino group at the end of L X is —CO—, —CH(COOH)CO—, —N(CH a) the above-mentioned X forms an amide bond with an amino group in W through the bond of the underlined carbonyl C, when W is an amino acid residue or a series of amino acid residues, or b) the above-mentioned X forms an amide bond with the amino group at the end of L Y is —(CH Z is —COOH, —CO-Asp, —CO-Glu, —CO-Gly, —CO-Sar, —CH(COOH) the structure of general formula 2 is wherein O J and M M the structure of general formula 3 is wherein J is defined above and R the structure of general formula 4 is wherein R