Patent ID: 9574000
Date: 2017-02-21
CPC Classifications: A61K,A61P,C07K,G01N

Claim:
1. A molecule, comprising an antigen-binding fragment of a humanized variant of anti-human B7-H4 antibody 6H3, wherein said molecule immunospecifically binds to human B7-H4, and wherein said antigen-binding fragment comprises: (1) a light chain variable region of a humanized variant of anti-human B7-H4 antibody 6H3, wherein said light chain variable region has the amino acid sequence of any of SEQ ID NOS: 18-23; and (2) a heavy chain variable region of a humanized variant of anti-human B7-H4 antibody 6H3, wherein said heavy chain variable region has the amino acid sequence of any of SEQ ID NOS:24-29.