Patent ID: 9562111
Date: 2017-02-07
CPC Classifications: A61K,A61P,C07K

Claim:
1. A method of making a soluble hydrophobic-core carrier, comprising: step (a): contacting and reacting a carboxyl group or an alkyl carboxyl group of a hydrophilic polymeric protective chain with a carbodiimide reagent to provide a hydrophilic polymeric protective chain having an activated carboxyl group or an activated alkyl carboxyl group; step (b): mixing and reacting a plurality of the hydrophilic polymeric protective chain having the activated carboxyl group or the activated alkyl carboxyl group of step (a) and a polymer comprising a linear polymeric backbone comprising NH step (c): contacting and reacting a hydrophobic molecule comprising a free carboxyl group with a carbodiimide reagent to provide a hydrophobic molecule comprising an activated carboxyl group; step (d): mixing and reacting the hydrophobic molecule comprising the activated carboxyl group of step (c) and the polymer comprising the linear polymeric backbone comprising a plurality of covalently-linked hydrophilic polymeric protective side chains and NH wherein the hydrophobic-core carrier comprises wherein the total weight ratio of the plurality of hydrophilic polymeric protective side chains and the hydrophobic moieties is in the range of 15:1 to 43:1 and wherein the hydrophobic-core carrier is soluble in water.