Patent ID: 9556270
Date: 2017-01-31
CPC Classifications: A61P,C07K,G01N

Claim:
1. A monoclonal antibody or an antigen-binding fragment, which binds to an extracellular region of human T-cell immunoglobulin and mucin domain containing molecule-3 (TIM-3) while competing with one antibody selected from the following (a) to (c): (a) an antibody or an antigen-binding fragment thereof, each comprising a heavy chain (H chain) and a light chain (L chain), wherein complementarity determining regions (CDRs) 1 to 3 of said H chain comprises the amino acid sequences of SEQ ID NOs: 1 to 3, respectively, and CDRs 1 to 3 of said L chain comprises the amino acid sequences of SEQ ID NOs: 4 to 6, respectively, (b) an antibody or an antigen-binding fragment thereof, each comprising an H chain and L chain, wherein CDRs 1 to 3 of said H chain comprises the amino acid sequences of SEQ ID NOs: 11 to 13, respectively, and CDRs 1 to 3 of said L chain comprises the amino acid sequences of SEQ ID NOs: 14 to 16, respectively, and (c) an antibody or an antigen-binding fragment thereof, each comprising an H chain and L chain, wherein CDRs 1 to 3 of said H chain comprises the amino acid sequences of SEQ ID NOs: 21 to 23, respectively, and CDRs 1 to 3 of said L chain comprises the amino acid sequences of SEQ ID NOs: 24 to 26, respectively, wherein the monoclonal antibody or the antigen-binding fragment thereof binds to the amino acid residues at positions 67 to 105, the amino acid residues at positions 67 to 96 or the amino acid residues at positions 67 to 87 in the amino acid sequence of IgV domain of human T-cell immunoglobulin and mucin domain containing molecule-3 (TIM-3) of SEQ ID NO: 53.