Patent ID: 9669100
Date: 2017-06-06
CPC Classifications: A01K,A01N,A61K,C08J

Claim:
1. A vehicle-free method of loading a naturally crystalline substance solubilized by a solvent mixture in a lipophilic medium into a mixture of polymer granules for forming a plasticizer-free polymer support for long-term controlled release of the naturally crystalline substance in a stable solubilized state, wherein said method ensures the permanent non-crystallization on a surface of said polymer support, said method comprising the steps of: a) preparation of said solvent mixture which comprises an oxygenated solvent of dibasic esters of methylenic fatty acids and an oxygenated methylenic cosolvent; b) solubilization of said naturally crystalline substance in said solvent mixture of step a) to obtain a stable solution of said naturally crystalline substance; c) addition of a vegetable oil in said stable solution of step b) to obtain an active lipophilic solution; d) incorporation of said active lipophilic solution obtained in step c) into a mixture of polymer granules comprising a polyether block amide (PEBA) and a thermoplastic polyurethane elastomer (TPU) to form a polymer mixture loaded with said naturally crystalline substance in said stable solubilized state; e) forming of said polymer support loaded with said naturally crystalline substance in a stable solubilized state by shaping said mixture of polymer granules loaded with said naturally crystalline substance obtained in d).