Patent ID: 9670276
Date: 2017-06-06
CPC Classifications: A61K,A61P,C07K

Claim:
1. A binding protein that specifically binds to both IL-1α and IL-1β, said binding protein comprising an IL-1β antigen binding domain comprising six CDRs, wherein the six CDRs are CDR-H1, CDR-H2, CDR-H3, CDR-L1, CDR-L2, and CDR-L3, as defined below: the CDR-H1 comprises the amino acid sequence of residues 31-35 of SEQ ID NO:34; the CDR-H2 comprises the amino acid sequence of residues 50-65 of SEQ ID NO:34; the CDR-H3 comprises the amino acid sequence of residues 98-111 of SEQ ID NO:34; the CDR-L1 comprises the amino acid sequence of residues 24-34 of SEQ ID NO:348; the CDR-L2 comprises the amino acid sequence of residues 50-56 of SEQ ID NO:348; and the CDR-L3 comprises the amino acid sequence of residues 89-97 of SEQ ID NO:348, wherein the binding protein comprises a heavy chain variable domain and a light chain variable domain that binds IL-1α and a heavy chain variable domain and a light chain variable domain that binds IL-1β.