Patent ID: 9592205
Date: 2017-03-14
CPC Classifications: A61K,B82Y,Y10S

Claim:
1. A method for preparing capsules encapsulating hydrophobic medicines, comprising the steps of: (A) providing an organic solution having a biocompatible polymer and a hydrophobic medicine; (B) stirring the organic solution at a low temperature of 3 to 10° C., and titrating with an alcohol solution, to make the biocompatible polymer encapsulate the hydrophobic medicine to form a capsule nanoparticle; (C) ultrasonic vibrating the capsule nanoparticle at a low temperature of 3 to 10° C.; (D) filtering the capsule nanoparticle, to make an average capsule nanoparticle diameter of the capsule nanoparticle at 60-450 nm; and (E) lyophilizing the capsule nanoparticle; Wherein the biocompatible polymer is selected from the group consisting (poly-(D,L-lactide-co-glycolide)), PLA, and PEG-PLA; and wherein the steps (A) to (E) are performed without surfactant.