Patent ID: 9636420
Date: 2017-05-02
CPC Classifications: A61K,A61P,C07K

Claim:
1. A protein complex, comprising a physiologically active polypeptide, a dimeric protein, and a non-peptidyl polymer linker, said non-peptidyl polymer linker having three functional ends, wherein the physiologically active polypeptide and the dimeric protein are linked to the functional ends of the non-peptidyl polymer via respective covalent bonds, wherein two of the three functional ends of the non-peptidyl polymer are covalently linked to two N-terminal amino groups of the dimeric protein, respectively, and remaining one of the three functional ends of the non-peptidyl polymer is covalently linked to the physiologically active polypeptide, wherein the dimeric protein is an immunoglobulin Fc domain, and wherein the non-peptidyl polymer has three functional aldehyde groups at respective termini thereof.