Patent ID: 9644012
Date: 2017-05-09
CPC Classifications: C07K,C12N

Claim:
1. A fusion protein comprising (i) at least one solubility-enhancing moiety, wherein each solubility-enhancing moiety has at least 90% identity to the amino acid sequence of SEQ ID NO:6; and (ii) at least one moiety which is a desired non-spidroin protein or a desired non-spidroin polypeptide, wherein the desired non-spidroin protein or the desired non-spidroin polypeptide is selected from the group consisting of amyloid-forming proteins, amyloid-forming polypeptides, surfactant protein B (SP-B), variants of SP-B containing disulphide, apolipoproteins, membrane proteins, membrane polypeptides, protein drugs, polypeptide drugs, aggregation-prone proteins, aggregation-prone polypeptides, and proteases, wherein the desired non-spidroin protein or the desired non-spidroin polypeptide has less than 30% identity to any of the amino acid sequences of SEQ ID NO: 6-10, wherein each solubility-enhancing moiety is linked directly or indirectly to the desired non-spidroin protein or the desired non-spidroin polypeptide moiety, and wherein the desired non-spidroin protein or the desired non-spidroin polypeptide excludes thioredoxin.