Patent ID: 9724386
Date: 2017-08-08
CPC Classifications: A61K,C07K

Claim:
1. A method for treating a subject with Type 1 diabetes or prediabetes, comprising: selecting a subject with Type 1 diabetes or prediabetes; and administering to the subject a therapeutically effective amount of (a) a wild type human osteoprotegerin, an osetoprotegerin polypeptide comprising the amino acid sequence set forth as SEQ ID NO: 1, or an osetoprotegerin polypeptide comprising the amino acids 22-401 of the amino acid sequence set forth as SEQ ID NO: 1, or (b) a fusion protein thereof that binds receptor activator of nuclear factor kappa-B ligand (RANKL), thereby treating Type 1 diabetes or prediabetes in the subject or inhibiting recent onset of Type 1 diabetes in the subject.