Patent ID: 9732126
Date: 2017-08-15
CPC Classifications: C07B,C07K,C12N,C12Y,G01N

Claim:
1. A method for screening a substance regulating interaction between thioredoxin (TRX) and thioredoxin-interacting protein (TXNIP), comprising: (a) preparing at least one crystal selected from the group consisting of (b) obtaining a three-dimensional structure of the at least one crystal using X-ray crystallography to generate a X-ray diffraction data; (c) synthesizing or selecting a candidate substance regulating interaction between TRX and TXNIP based on a three-dimensional structure of the at least one crystal, wherein the candidate substance is a compound or peptide; (d) contacting the candidate substance with the TRX and the TXNIP to examine whether the candidate substance regulates interaction between TRX and TXNIP.