Patent ID: 9682043
Date: 2017-06-20
CPC Classifications: A61K

Claim:
1. A method of preparing mixed phase co-crystal composition consisting of the steps of: (a) forming a first solution of progesterone, hydroxypropyl methylcellulose, and polyoxamer 188 dissolved in ethanol; (b) mixing water with the first solution to form a second solution; (c) mixing or allowing the second solution to stand for a sufficient period of time to form an initial kinetically favored meta-stable crystalline phase in the second solution, (d) forming the thermodynamically favored mixed phase co-crystal composition from the meta-stable crystalline phase by allowing the initial meta-stable crystalline phase to stand or by mixing of the initial meta-stable crystalline phase, (e) optionally, isolating the mixed phase co-crystal composition, (f) optionally, washing the mixed phase co-crystal composition, and (g) optionally, drying the mixed phase co-crystal composition, wherein the progesterone, hydroxypropyl methylcellulose, and polyoxamer 188 are contained within the mixed phase co-crystal composition.