Patent ID: 9701711
Date: 2017-07-11
CPC Classifications: A61K,A61P,C07K

Claim:
1. A method for the therapeutic treatment of a disease or disorder associated with undesirable PAR2 activity selected from arthritis, colitis and inflammatory bowel disease, pancreatitis, stroke, gastric ulcer, asthma, epilepsy, Alzheimer's disease, diabetes, irritable bowel syndrome and cancers of the stomach, colon, bowel, breast, liver or pancreas, comprising administering to a subject in need thereof a compound of the formula (I): wherein R R R wherein the C R R R C(O)NHCHR R R or R the phenyl, benzyl, aminoaryl, heterocycle or fused aromatic or aliphatic C the fused aromatic or aliphatic C R R a salt thereof; provided that the compound is not 5-isoxazoyl-Cha-Ile-spiro[indene-1,4′-piperidine], 5-isoxazoyl-Cha-Ile-spiro[indane-1,4′-piperidine] or 5-isoxazoyl-Cha-Ile-spiro[octahydro-1H-indene-1,4′-piperidine].