Patent ID: 9615747
Date: 2017-04-11
CPC Classifications: A61B,A61K

Claim:
1. A method for topical skin treatment evaluation, the method comprising: illuminating the skin area of each of a plurality of human subjects at a plurality of excitation wavelengths; detecting peak skin fluorescence levels for each of the plurality of human subjects at a plurality of emission wavelengths having a first emission wavelength and a second emission wavelength, each of the plurality of emission wavelengths corresponding to fluorophores of at least one of a glycated protein and an advanced glycated end-product; applying a regimen of a topical anti-glycation skin treatment to a skin area of at least one of the plurality of human subjects; after application of the regimen of the topical anti-glycation skin treatment, illuminating the skin area of each of the plurality of human subjects at the plurality of excitation wavelengths; detecting a change over time in the intensity of the peak skin fluorescence levels at the first emission wavelength and at the second emission wavelength, the change including an increase in intensity at the first emission wavelength and a decrease in intensity at the second emission wavelength; determining relative levels of skin glycation for each of the plurality of human subjects based at least partially on the detected change in intensity of the peak skin fluorescence levels of the first emission wavelength and the second emission wavelength; and evaluating the efficacy of the topical anti-glycation skin treatment based at least partially on the relative skin glycation levels for each of the plurality of human subjects.