Patent ID: 9687537
Date: 2017-06-27
CPC Classifications: A61K,A61P,C12N

Claim:
1. A method of reducing growth of an aspartyl (asparaginyl)-β-hydroxylase (AAH)-expressing tumor in a subject, comprising providing an isolated mature AAH-loaded dendritic cell and administering to said subject said isolated mature AAH-loaded dendritic cell, wherein growth of said AAH-expressing tumor is reduced after administration of said dendritic cell, and wherein said dendritic cell is primed by contact with an AAH followed by contact with a combination of cytokines comprising GM-CSF (Granulocyte-macrophage colony stimulating factor), CD40L (Cluster of Differentiation 40 ligand), and IFN-γ (interferon gamma) ex vivo, prior to said administering to said subject.