Patent ID: 9561241
Date: 2017-02-07
CPC Classifications: A61K

Claim:
1. A method for treating acne in a patient comprising: administering to said patient an oral dosage form comprising minocycline wherein the dosage form comprises an immediate release component and a delayed release component; controlling the spatial and temporal delivery of the minocycline administered in the delayed release component of the oral dosage form into a gastrointestinal area of the patient selected from the group consisting of the stomach, the duodenum of the small intestine, and a combination thereof; wherein the delayed release component of the oral dosage form has a modified release profile and/or a physicochemical profile selected from the group consisting of floatable, swellable, bioadhesive, osmotic, and any combination thereof; wherein the delayed release component of the oral dosage form regulates the release of minocycline into the gastrointestinal area of the patient such that the oral dosage form exhibits T wherein the controlled temporal release in the gastrointestinal area of the patient is completed in about 2.5 hours to about 7.0 hours after administration to the patient; and wherein the oral dosage form has a bioavailability of minocycline of 50% or greater relative to an immediate release dosage form.