Patent ID: 9718797
Date: 2017-08-01
CPC Classifications: A01N,C07D

Claim:
1. A method for preparing a mixture of eight diasteromers of vittatalactone comprising the following steps: (a) reacting ethyl propionate with isobuteraldehyde to obtain (b) reacting with diisobutyl aluminum hydride followed by pyridinium chlorochromate to obtain (E)-2,4-dimethylpent-3-enal (c) reacting and ethyl 2-(diethoxyphosphoryl) propanoate to obtain (2E,4E)-ethyl 2,4,6-trimethylhepta-2,4-dienoate (d) reacting and diisobutyl aluminum hydride followed by pyridinium chlorochromate to obtain (e) reacting and ethyl 2-(diethoxyphorphoryl) propanoate to obtain (f) reacting and diisobutyl aluminum hydride to obtain intermediate 6 (g) reacting intermediate 6 with H (h) reacting and pyridinium chlorochromate followed by ethyl 2-(diethoxyphorphoryl) propanoate to obtain (i) reacting and diisobutyl aluminum hydride to obtain (j) reacting and tert-butylhydro-peroxide in presence of chiral auxiliary (−)-diethyltartrate to obtain (k) reacting and NaCNBH (i) reacting and NaHCO and (m) reacting and para-toluenesulfonyl chloride to obtain a mixture of eight diasteromers of vittatalactone