Patent ID: 9700544
Date: 2017-07-11
CPC Classifications: A61K

Claim:
1. A microparticle pharmaceutical preparation, comprising: an enteric coating comprising a solid excipient matrix, said solid excipient matrix comprising a polymer composition that remains intact when exposed to acidic conditions of the alimentary canal of an animal and that disintegrates in near-neutral to basic conditions of targeted intestinal portions of said alimentary canal; said polymer comprising a copolymer of methacrylic acid and methyl methacrylate; rapamycin nanoparticles dispersed within said matrix, said rapamycin nanoparticles comprising a micelle-inducing compound, wherein said micelle-inducing compound comprises sodium cholate, and a pharmaceutically active core comprising said rapamycin nanoparticles; and said micelle-inducing compound naturally inducing formation of micelles with a solution of said micelle-inducing compound, said micelles having properties that promote stability of said rapamycin when said rapamycin nanoparticles are dispersed within said matrix; and said rapamycin nanoparticles are sized in the range between about 1 nanometer and about 1 micron.