Patent ID: 9610301
Date: 2017-04-04
CPC Classifications: A61K,A61P,C07K

Claim:
1. A pharmaceutical powder preparation comprising an effective amount of adalimumab and sodium hyaluronate, wherein the pharmaceutical powder preparation is prepared by spray drying a solution comprising more than about 50 mg/mL of adalimumab and an excipient which is either trehalose or sucrose, and wherein the pharmaceutical powder preparation has an excipient:adalimumab mass ratio of about 0.7:1.0 or about 1.4:1.0, comprises less than about 6% residual moisture, comprises no more than 2% aggregates upon reconstitution when stored as a powder at 25° C. for three months, and comprises no more than 5% aggregates upon reconstitution when stored as a powder at 40° C. for three months.