Patent ID: 9745626
Date: 2017-08-29
CPC Classifications: C12Q,G16B,G16C

Claim:
1. A method for processing a nucleic acid sample of a subject, comprising: (a) generating at least a first subset of nucleic acid molecules and a second subset of nucleic acid molecules from said nucleic acid sample of said subject, wherein said first subset of nucleic acid molecules is generated to differ from said second subset of nucleic acid molecules by genomic features selected from the group consisting of methylation state, GC content, insertion or deletion, single nucleotide variant (SNV) and molecular size with the aid of probes that selectively enrich for said genomic features as compared to other probes that do not selectively enrich for a difference in said genomic features; (b) subjecting (i) said first subset of nucleic acid molecules to a first assay to yield a first result comprising a first nucleic acid sequence, and (ii) said second subset of nucleic acid molecules to a second assay to yield a second result comprising a second nucleic acid sequence; and (c) combining, with the aid of a computer processor, said first result and said second result to generate an output comprising a consensus sequence from said first nucleic acid sequence and said second nucleic acid sequence.