Patent ID: 9718857
Date: 2017-08-01
CPC Classifications: A61P,C07K

Claim:
1. A method of inhibiting neuronal necrosis and inducing neurite growth in vitro comprising administering to neuronal cells an effective amount of a teneurin c-terminal associated peptide (TCAP peptide), or a pharmaceutically acceptable salt thereof, wherein the amino acid sequence of said TCAP peptide consists essentially of: (i) an amino acid sequence having at least 95% identity to an amino acid sequence selected from the group consisting of SEQ ID NOs: 37, 38, 69, 70, and 101; or optionally wherein: (a) the carboxy terminal end of said TCAP peptide is amidated or comprises an amidation signal sequence; or (b) when the amino terminal amino acid of said TCAP peptide is glutamine, it is in the form of pyroglutamic acid.