Patent ID: 9732024
Date: 2017-08-15
CPC Classifications: C07C

Claim:
1. A Method to purify ferulic acid and/or salts thereof, where the ferulic acid and/or salts thereof are extracted by a method of extraction, with purity less than to 90% and in solid state; wherein said method comprises: dissolving ferulic acid and/or salts thereof totally, with a selective organic solvent; recovering and separate the solution from water insoluble impurities with the help of filters; recovering the selective organic solvent by subjecting the solution to evaporation in a vacuum evaporator that allows the recovery of the selective organic solvent at a temperature between 30 and 60° C., with a vacuum between 400 to 700 Hg mm; mixing with water the concentrated extract of ferulic acid and/or salts thereof, from the previous step, in a ratio of 1:1, to pre-crystallize the impurities soluble in water; evaporating the mixture to remove the remains of organic solvent, at a temperature of 60° C., approximately; concentrating the mixture free of solvent in an evaporator, at 30 to 60° C., with 400 to 700 Hg mm to obtain a final volume of about 40 to 50%; cooling the concentrated mixture at 40° C., approximately; letting the concentrated mixture to set, around 1 h, to isolate by sedimentation the water-insoluble impurities; re-heating the mixture free from impurities at 70° C.; purifying the re-heated mixture through a synthetic purification resin; transferring the purified mixture to a crystallizing container with cooling jacket, where the ferulic acid and/or salts thereof crystallize after 4 h of being set, at a temperature of 15° C., with purity from 98 to 99.9%; removing the mother liquor of crystallization from the precipitate of ferulic acid and/or salts thereof, through centrifugation at 1000 rpm for 20 min; and drying the ferulic acid and/or salts thereof, to be purified, in a drying apparatus having vacuum trays and an inert atmosphere, for 2 h, to obtain humidity less than 1%.