Patent ID: 9745579
Date: 2017-08-29
CPC Classifications: A61K,A61P,C12N,Y02A

Claim:
1. A method of treating or preventing a hyperproliferative disorder and/or a disorder characterised by hypoalbuminemia, said method comprising administering to a subject in need thereof a short activating RNA which up-regulates albumin production, wherein said short activating RNA upregulates albumin production by activating a target gene, wherein the target gene is HNF4a, and wherein, (i) said short activating RNA comprise a strand that is at least 95% complementary to a sequence located on the coding strand of the target gene between 500 nucleotides upstream and 500 nucleotides downstream of the transcription start site of the target gene, and (ii) said short activating RNA comprises a sequence of at least 18 nucleotides.