Patent ID: 9574006
Date: 2017-02-21
CPC Classifications: A61P,C07K

Claim:
1. A method of treating a CD30-expressing cancer comprising administering to a subject in need thereof an anti-CD30 antibody, said antibody comprising: at least one amino acid substitution in the Fc region at a position selected from the group consisting of 239D and 332E relative to a parent Fc region; and a heavy chain and a light chain, wherein said heavy chain comprises a heavy chain variable region comprising an amino acid sequence of SEQ ID NO 11, and wherein said light chain comprises a light chain variable region comprising an amino acid sequence of SEQ ID NO 10, and said antibody binds with enhanced affinity to FcyRllla as compared to a parent antibody, wherein numbering is according to the EU index as in Kabat.