Patent ID: 9539363
Date: 2017-01-10
CPC Classifications: A61L,A61P

Claim:
1. A method for making a biodegradable collagen matrix, the method comprising: providing an acidic collagen slurry; mixing at least one water soluble and/or hydrophilic bioactive agent with the acidic collagen slurry under conditions sufficient to cause the collagen slurry to self-assemble into macroscopic collagen fibers having a length from about 3 mm to about 30 mm, from about 5 mm to about 25 mm or from about 7.5 mm to about 20 mm and cause the at least one bioactive agent to form a collagen matrix containing the bioactive agent; adding an osteoclastogenesis inhibitor to the collagen matrix; and adding an osteoinductive additive comprising particulate demineralized bone matrix comprising bone chips, wherein the conditions sufficient to cause the collagen slurry to self-assemble comprise: (i) raising the pH of the slurry from 8 to about a pH of 9; or (ii) adding bone powder, calcium phosphate, hydroxyapatite, DBM or a mixture thereof to the slurry to raise the pH from 8 to about 9, and disposing the formed collagen matrix into a containment device comprising a biodegradable porous polymer mesh bag.