Patent ID: 9557333
Date: 2017-01-31
CPC Classifications: G01N

Claim:
1. A method of treating a gastrointestinal sarcoma (GIST) in a subject, the method comprising the steps of: a) determining, in a biological sample of said subject, the expression level of soluble B7H6 (sB7H6) and the presence or absence of soluble MIC (sMIC) in an enzyme linked immunosorbent assay (ELISA); b) comparing said expression level of sB7H6 in the biological sample of the subject to a sB7H6 reference expression level in an ELISA; and c) treating GIST in the subject by administering to the subject: wherein the appropriate chemotherapeutic treatment comprises an anti-B7-H6 neutralizing antibody and an immunomodulator stimulating T and/or NK cell production or activity, and wherein the sB7H6 reference expression level is the level of the sB7H6 polypeptide in one or more control samples derived from one or more individuals having GIST.