Patent ID: 9684002
Date: 2017-06-20
CPC Classifications: G01N

Claim:
1. A method for diagnosing and treating acute kidney injury (AKI) in a patient following an event likely to cause kidney injury and/or failure in the patient, comprising: (A) obtaining a urine or plasma sample from a patient; (B) measuring levels for urine or plasma hepcidin, and measuring levels of creatinine in the urine or plasma sample of said patient following said event; and (C) diagnosing the patient with predicted risk of AKI using a ratio of (uHep/uCr):pHep, calculated by dividing a ratio of urine hepcidin to urinary creatinine (uHep/uCr) by plasma hepicidin (pHep), wherein a lack of an increase in the (uHep/uCr):pHep ratio at about 6 hours compared to the ratio at about 24 hours following the event is indicative of an increased risk for AKI; and (D) administering an effective amount of sodium bicarbonate to the patient diagnosed with increased risk for AKI as an intervention treatment by intravenous loading of sodium bicarbonate followed by a continuous infusion of sodium bicarbonate, wherein the event is cardiopulmonary bypass (CPB) surgery.