Patent ID: 9745334
Date: 2017-08-29
CPC Classifications: A61K,A61P,C07D,C07H

Claim:
1. A compound according to the chemical structure: Where X is W or W′ is each independently H, —(CH n and n′ are each independently 2-8; Each n″ is independently 0, 1, 2, 3, 4, 5, or 6; i is 0 or 1; [LL] is a labile linker according to the chemical structure: where R is an ethylene glycol group, or a methylene group and n in this labile linker is from 0 to 10; X is O, N—R R Y is O or S and Z=Me, Et, iPr, tBu, Ph, each of which may be optionally substituted with one or more halogen groups and where said Ph group may be further optionally substituted with OMe or a C [LL] is a group according to the chemical formula: and R is an ethylene glycol group, or a methylene group and n in this labile linker is from 0 to 10; or [LL] is an enzymatically cleaved labile linker according to the chemical structure: Where the protease substrate is a peptide containing from 2 to 50 amino acid units, and R is an ethylene glycol group, or a methylene group; and n in this labile linker is from 0 to 10; or [LL] is a group according to the chemical structure: Where the points of attachment in each of the labile linkers as indicated are joined to other portions of the molecule as indicated; [NLL] when present is a (poly)ethylene glycol linker of from 2 to 8 ethylene glycol units, or [NLL] is a group: where each X R S i is 0 or 1; and m [CYT] is a group according to the chemical structure: wherein X is a group —NR where R the symbol or a pharmaceutically acceptable salt or stereoisiomer thereof.