Patent ID: 9683995
Date: 2017-06-20
CPC Classifications: A61K,A61P,C07K,C12N,C12Q,C12Y,G01N

Claim:
1. A method for treating cancer in a subject, the method comprising: (a) selecting a subject having at least one solid tumor or growth or a nevus; (b) measuring the level of SETDB1 in a biological sample from the at least one solid tumor or growth or nevus obtained from the subject, wherein the level of SETDB1 is detected at the mRNA level by a PCR procedure or at the protein level by an immunoassay; (c) identifying the likelihood of cancer in the subject by comparing the measured level of SETDB1 to a reference level, and assessing for an increase in the measured SETDB1 level in the sample compared to the reference level, wherein the reference level is the level of SETDB1 in a subject or group of subjects who are clinically free of cancer and the level of SETDB1 in the cancer-free subject(s) is detected in the same manner as the measured subject, either at the mRNA level by a PCR procedure or at the protein level by an immunoassay; (d) determining that the subject requires a cancer treatment when there is an increase of at least 10% SETDB1 level in the biological sample compared to the reference level; and (e) administering an effective therapeutic amount of an anti-cancer agent to the subject.