Patent ID: 9701963
Date: 2017-07-11
CPC Classifications: A61K,A61P,C07K,C12N

Claim:
1. A method of inhibiting complement component C5 expression in a cell, the method comprising: contacting the cell with a double stranded ribonucleic acid (dsRNA) agent that inhibits expression of a complement component C5 gene, wherein the dsRNA agent comprises a sense strand and an antisense strand forming a double stranded region 15-30 nucleotide pairs in length, the antisense strand comprising a region of complementarity which comprises at least 15 contiguous nucleotides differing by no more than 3 nucleotides from nucleotides 769-821 of SEQ ID NO:1; and contacting the cell with an anti-complement component C5 antibody, or antigen-binding fragment thereof, thereby inhibiting expression of the complement component C5 gene in the cell.