Patent ID: 9737641
Date: 2017-08-22
CPC Classifications: A61K,A61L,A61P,B65B,Y10T

Claim:
1. A method of fabricating an implantable medical device comprising a rapamycin derivative drug, the method comprising: a) synthesizing the rapamycin derivative drug; b) recrystallizing the rapamycin derivative drug from an appropriate recrystallization solvent where the appropriate cold recrystallization solvent is ethanol; c) washing the recrystallization-solvent-wetted recrystallized rapamycin derivative drug with a small amount of a cold recrystallization solvent; d) dissolving the recrystallization-solvent-wetted recrystallized rapamycin derivative drug immediately in an appropriate coating composition solvent; e) adding a desired weight percent, based on the weight of rapamycin derivative drug, of a pharmaceutically acceptable antioxidant stabilizer to form the coating composition; and f) disposing the coating composition on the implantable medical device to form a drug reservoir layer.