Patent ID: 9737640
Date: 2017-08-22
CPC Classifications: A61K,A61L,A61M

Claim:
1. A balloon catheter for delivering a therapeutic agent to a target site of a body lumen chosen from an esophagus, an airway, a sinus, a trachea, a colon, a biliary tract, a urinary tract, or a prostate, the balloon catheter comprising a balloon and a coating layer overlying external surfaces of the balloon, wherein: the coating layer consists essentially of a water-soluble first additive, a water soluble second additive, and a hydrophobic therapeutic agent; the hydrophobic therapeutic agent is selected from the group consisting of paclitaxel, rapamycin, everolimus, docetaxel, daunorubicin, doxorubicin, beta-lapachone, biologically active vitamin D, and combinations thereof; the water-soluble first additive is selected from the group consisting of gluconolactone, PEG laurates, PEG oleates, PEG stearates, PEG glyceryl laurates, PEG glyceryl oleates, PEG glyceryl stearates, PEG sorbitan monolaurates, PEG sorbitan monooleates, PEG sorbitan stearates, PEG sorbitan laurates, PEG sorbitan oleates, and PEG sorbitan palmitates; and the water-soluble second additive is selected from the group consisting of sorbitol, sorbitan, xylitol, lactobionic acid, and combinations thereof.