Patent ID: 9581596
Date: 2017-02-28
CPC Classifications: C07K,C12N,G01N

Claim:
1. A method for monitoring the effectiveness of treatment to a human subject with an anti-HIV agent, comprising: detecting a HIV-associated biomarker profile consisting of HIV-associated proteins in urine exosomes in one or more urine samples obtained from a human subject prior to administration of said anti-HIV agent; detecting a HIV-associated biomarker profile consisting of HIV-associated proteins in urine exosomes in one or more post-administration urine samples of said human subject; comparing the HIV-associated biomarker profile in the pre-administration sample or samples with the HIV-associated biomarker profile in the post administration sample or samples; and determining the effectiveness of said anti-HIV agent, wherein a reduction in level of HIV-associated proteins indicates effectiveness of treatment, and wherein said HIV-associated biomarker profile consists of one or more HIV-associated proteins selected from the group consisting of Nef, HIV envelope gp120, HIV protease, Vif, Gag-Pol, Gag, Rev, reverse transcriptase (RT), Tat, p1, p17, Vpu, Vpr, gp41and DNA polymerase.