Patent ID: 9550788
Date: 2017-01-24
CPC Classifications: A61P,C07D

Claim:
1. A compound of the formula I in which A is phenyl, where one or more hydrogen atoms in said phenyl may be replaced by one or more substituents R1; substituents R1 are selected independently of one another from the group of F, Cl, Br, I, (C where said alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, cycloalkylalkyloxy, cycloheteroalkyl, alkoxy, and alkylthio radicals may be substituted independently of one another one or more times by F, OH or (C B is a mono- or fused bicyclic radical selected from the group of 6 to 10 membered aryl radicals, of 5 to 10 membered heteroaryl radicals, of 3 to 10 membered cycloalkyl radicals, of 9 to 14 membered cycloalkylaryl radicals, of 8 to 14 membered cycloalkyiheteroaryl radicals, of 3 to 10 membered cycloheteroalkyl radicals, of 9 to 14 membered cycloheteroalkylaryl radicals and of 8 to 14 membered cycloheteroalkylheteroaryl radicals, where the cycloalkyl or cycloheteroalkyl units may be saturated or partly unsaturated, and where the heterocyclic groups have one or more heteroatoms selected from the group of nitrogen, oxygen and sulfur; where one or more hydrogen atoms in the radicals B may be replaced by substituents R5; the cycloalkyl and cycloheteroalkyl units may be saturated or partly unsaturated, and where one or more hydrogen atoms in said radicals R5 may be replaced by further radicals which are selected independently of one another from the group of R11 radicals, it is further possible for R5 to be one or more radicals which are selected independently of one another from the group of OH, (═O), NH all of which may be substituted independently of one another by OH, (═O), F, Cl, Br, I, CN, NO where the heterocycle formed may be substituted one or more times by F, OH, (═O), NH L is a covalent bond; X is a group —O—; R2 is absent or is one or more substituents which may be selected independently of one another from the group of F, (C R3 and R4 are independently of one another a hydrogen radical or a radical which is selected from the group of (C R3 and R4 form together with the nitrogen to which they are bonded a 4-10 membered, saturated, unsaturated or partly unsaturated heterocycle which may additionally comprise one or more further heteroatoms from the group —O—, —S(O) the heterocycle formed may be bridged by a bond, by a saturated or unsaturated (C the alkyl and heteroalkyl chain may also form a spirocyclic ring system with the ring system formed by R3 and R4, where the alkyl and heteroalkyl bridges may be substituted independently of one another one or more times by radicals selected from the group of R7 and R9, and where R8 in the group —NR8- may form with the ring which R3 and R4 may form a further saturated, unsaturated or partly unsaturated heterocycle which may be substituted independently of one another one or more times by radicals selected from the group of R7 and R9, and may additionally comprise one or more further heteroatoms from the group —O—, —S(O) R7 is a (C R8 is an H, a (C R9 is a radical selected from the group of OH, (═O), F, Cl, Br, I, CN, NO R10 is a radical selected from the group of F, OH, CN, (C R11 is a radical selected from the group of (C all of which may be substituted independently of one another one or more times by R10; R11 can also be a radical selected from the group of (═O), Cl, Br, I and R10; R12, R13 and R14 are independently of one another selected from H, (C R13 and R14 may form together with the nitrogen to which they are bonded a 4-7 membered, saturated, unsaturated or partly unsaturated heterocycle, which may additionally comprise one or more further heteroatoms from the group —O—, —S(O) the formed heterocycle may be substituted one or more times by F, OH, (═O), NH R15 is a radical selected from the group of H, (C R19 is H, (C and in which n is 0, 1 or 2; p 2; and q is 0, or a pharmaceutically acceptable salt thereof, and in which i) in the case where B is phenyl or benzodioxolanyl and R3 and R4 are H, (C ii) in the case where R3 and R4 are a (C