Patent ID: 9730925
Date: 2017-08-15
CPC Classifications: A61K,A61P,C12Q,G01N

Claim:
1. A method of treating cancer in a human in need thereof, comprising determining the presence of a mutation at the alanine 677 (A677) residue in Enhancer of Zeste Homolog 2 (EZH2) in a sample from said human; and administering to said human having a sample determined to have a presence of a mutation in A677 in EZH2 an effective amount of an EZH2 inhibitor or a pharmaceutically acceptable salt thereof, wherein the EZH2 inhibitor is a compound of Formula (I): wherein: W is N or CR X and Z are each independently selected from the group consisting of hydrogen, (C Y is hydrogen or halogen; R When present R R R each R R or R or R or a pharmaceutically acceptable salt thereof.