Patent ID: 9695206
Date: 2017-07-04
CPC Classifications: A61B,A61K,A61P,C07D,C07F,C12N,C12Q,G01N,H05K

Claim:
1. A nucleic acid molecule for inhibiting expression of p21 comprising a sense strand and an antisense strand, wherein the sense strand is AAG GAGU C AGA C A UU U U AA UU (SEQ ID NO:59) and the antisense strand is U U AaAa U gUC U GACUCCUU UU (SEQ ID NO:73); or wherein the sense strand is AAG GAGU C AGA C AUUU U AA UU (SEQ ID NOs:58) and the antisense strand is U U AaAa U gUC U GACUCCUU UU (SEQ ID NOs:72); or wherein the sense strand is AAG GAGU C AGA C A UU U U AA UU (SEQ ID NOs:60) and the antisense strand is U U AaAaUgUCUGACUCCUU UU (SEQ ID NOs:74); wherein an uppercase letter refers to an unmodified ribonucleotide, wherein a lower case letter refers to 2′-deoxy, and wherein an underlined letter refers to 2′-OMe-substituted.