Patent ID: 9617332
Date: 2017-04-11
CPC Classifications: C07K,G01N

Claim:
1. A monoclonal antibody recognizing a conformational epitope formed by Phe at amino acid position 4 of trimeric or tetrameric human Aβ, as determined by pepscan ELISA comprising the steps of precoating with 100 ng Aβ wherein said monoclonal antibody does not bind human monomeric Aβ as determined by native Western-blotting comprising the steps of applying 7 μg Aβ wherein said monoclonal antibody comprises (a) a variable region that comprises a H-CDR1, a H-CDR2 and a H-CDR3 as shown in SEQ ID NOs: 1, 2 and 3, and a L-CDR1, a L-CDR2 and a L-CDR3 as shown in SEQ ID NOs: 4, 5 and 6 (NT4X-83); or (b) a variable region that comprises a H-CDR1, a H-CDR2 and a H-CDR3 as shown in SEQ ID NOs: 9, 10 and 11, and a L-CDR1, a L-CDR2 and a L-CDR3 as shown in SEQ ID NOs: 12, 13 and 14 (NT4X-167).