Patent ID: 9592306
Date: 2017-03-14
CPC Classifications: A01K,A61D,A61K,G01N

Claim:
1. A method for producing a mitochondrial-nuclear exchanged non-human animal, the method comprising: (a) selecting a non-human animal susceptible to a disease or disorder; (b) selecting a non-human animal that is not susceptible to the disease or disorder; (c) harvesting a pro-nuclear embryo from each of the non-human animals of steps (a) and (b); (d) enucleating the embryos of step (c); (e) transferring the nucleus from the embryo of the non-human animal that is not susceptible to the disease or disorder to the enucleated embryo of the non-human animal susceptible to the disease or disorder to make a resulting embryo, wherein the resulting embryo has mtDNA from the non-human animal susceptible to the disease or disorder and the nDNA from the non-human animal that is not susceptible to the disease or disorder; and (f) transferring the resulting embryo into an appropriate host and allowing the transferred embryo to develop into a progeny non-human animal, wherein the progeny non-human animal is a mitochondrial-nuclear exchanged non-human animal.