Patent ID: 9745339
Date: 2017-08-29
CPC Classifications: B01D,B01J,C07D,C07K

Claim:
1. A method of affinity purification of an antibody or a fragment of an antibody, comprising contacting the antibody or the fragment of the antibody with a ligand-substituted matrix, wherein the ligand-substituted matrix comprises: a support material and at least one ligand covalently bonded through a primary amino group of the ligand to the support material and binding to the Fc part of the antibody or the antibody fragment, wherein the ligand is selected from the group consisting of: 1-(8-Amino-3,5-dioxa-1-octyl)-2-methylbenzimidazole-5-carboxylic acid N-[5-(2-furyl)-1,3,4-thiadiazol-2-yl]amide, 1-(3-Amino-1-propyl)-2-methylbenzimidazole-5-carboxylic acid N-[5-(2-furyl)-1,3,4-thiadiazol-2-yl]amide, and 1-(3-Amino-1-propyl)benzimidazole-5-carboxylic acid N-[5-(2-furyl)-1,3,4-thiadiazol-2-yl]amide.