Patent ID: 9714893
Date: 2017-07-25
CPC Classifications: G01N

Claim:
1. A method for identifying an improved particle size distribution profile of a dispersion, the method comprising: (a) providing a dispersion comprising a liquid and particles dispersed in the liquid, wherein the dispersion is a lipid emulsion, a liposomal preparation, a micellar suspension, or a colloidal or biologic/protein-based dispersion, and wherein the dispersion is suitable for intravenous administration; (b) measuring a particle size distribution of the dispersion, resulting in a first particle size distribution profile; (c) adjusting at least one parameter associated with the dispersion; (d) measuring a dispersion characteristic, after adjustment of the at least one parameter; and (e) measuring the particle size distribution of the dispersion after adjustment of the at least one parameter, resulting in a second particle size distribution profile; wherein each of the first and second particle size distribution profiles comprises a plurality of data points of particle concentration values as a function of particle size, wherein the dispersion characteristic is selected from the group consisting of: a degree of particle agglomeration at a predetermined time after dispersion formation, and a dispersion stability.