Patent ID: 9585851
Date: 2017-03-07
CPC Classifications: A61K,A61N,A61P,G16H

Claim:
1. A method of modulating the autonomic nervous system of a subject having an orthopedic inflammatory condition caused by an abnormal balance of the sympathetic and parasympathetic functions of the autonomic nervous system comprising: determining the state of the subject's autonomic nervous system by measuring a parasympathetic activity/sympathetic activity ratio in at least a portion of the subject's autonomic nervous system; and administering to the subject an effective amount of at least one beta-blocker chosen from atenolol, betaxolol, bisoprolol, carvedilol, esmolol, labetalol, metoprolol, nadolol, pindolol, propranolol, sotalol, timolol, acebutalol, oxprenolol, carvedilol, and penbutolol, based on the determined state of the subject's autonomic nervous system to inhibit activity in at least a portion of the subject's sympathetic nervous system to produce a parasympathetic activity/sympathetic activity ratio in at least a portion of the subject's autonomic nervous system that is analogous to the parasympathetic activity/sympathetic activity ratio observed in a healthy 25 year old human subject and reduce at least one symptom associated with the orthopedic inflammatory condition caused by the abnormal balance of the sympathetic and parasympathetic functions of the autonomic nervous system, wherein the orthopedic inflammatory condition is osteoarthritis.