Patent ID: 9708364
Date: 2017-07-18
CPC Classifications: B65B,C07K,G01N,Y10T

Claim:
1. A method for producing a capsule for protein crystallization, comprising: adding a solution containing a protein and a gelling agent to an ionic cross-linking and crystallization solution, to thereby form an ionically cross-linked gel capsule, wherein the solution containing the protein and the gelling agent is added to the ionic cross-linking and crystallization solution by dropping, wherein the ionically cross-linked gel capsule is maintained in the ionic cross-linking and crystallization solution to thereby produce a protein crystal encapsulated within a shell of the ionically cross-linked gel capsule, and wherein the ionic cross-linking and crystallization solution comprises a buffer, a precipitant and a calcium ion, a concentration of the calcium ion in the ionic cross-linking and crystallization solution being higher than a concentration of a calcium ion in the solution containing the protein and the gelling agent.