Patent ID: 9655856
Date: 2017-05-23
CPC Classifications: A61K,A61P

Claim:
1. A method of preparing a pharmaceutical composition comprising the steps of: (a-1) wet granulating at least one active ingredient that is the compound 4-{[9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino}-2-methoxybenzoic acid or a pharmaceutically acceptable salt thereof, or a crystalline form thereof, and optionally one or more pharmaceutically acceptable excipients independently selected from the group consisting of surfactants, binders, and disintegrants in the presence of a suitable solvent to form a wet mixture; (a-2) drying the wet mixture from step (a-1), to form dried granules; (a-3) milling the dried granules from step (a-2), to form milled granules; and (a-4) blending the milled granules from step (a-3) with a buffer and optionally one or more pharmaceutically acceptable excipients independently selected from the group consisting of surfactants, binders, disintegrants, lubricants and glidants; wherein a filler is added during step (a-1), during step (a-4), or during both steps (a-1) and (a-4).