Patent ID: 9694105
Date: 2017-07-04
CPC Classifications: A61F,A61L

Claim:
1. A casted construct for treating damaged biological structures and tissue, comprising: a tissue prosthesis comprising a reinforced mammalian tissue structure, said mammalian tissue structure comprising first sterilized and acellular extracellular matrix (ECM) from a first mammalian tissue source, said mammalian tissue structure further comprising an intact, continuous, reinforced, sterilized and acellular internal vasculature, said internal vasculature and mammalian tissue structure being sterilized and decellularized by perfusion of a sterilant into said internal vasculature, said vasculature being infused with an ECM-mimicking biomaterial composition comprising poly(glycerol sebacate) (PGS), wherein a PGS augmented tissue prosthesis is formed, said PGS augmented tissue prosthesis being capable of modulating an inflammatory phase of damaged biological tissue, and inducing host cell and tissue proliferation, neovascularization, bioremodeling of said damaged biological tissue and regeneration of new tissue and tissue structures with site-specific structural and functional properties, when said PGS augmented tissue prosthesis is disposed proximate said damaged biological tissue.