Patent ID: 9603921
Date: 2017-03-28
CPC Classifications: A61K,A61P,C12N

Claim:
1. A virosome comprising: a virosomal membrane comprising at least one lipid, an envelope protein of influenza virus, and an envelope protein of hepatitis B virus (HBV); and nucleocapsid particles comprising HBc protein of HBV, wherein the nucleocapsid particles are attached to the envelope proteins of HBV through an interaction between the envelope proteins of HBV and the HBc proteins of HBV, wherein a first plurality of the nucleocapsid particles so attached are located on the inside of the virosome, wherein a second plurality of the nucleocapsid particles so attached are located on the outside of the virosome, wherein the nucleocapsid protein HBc lacks an exposed lipophilic domain, and wherein the virosome is able to induce a therapeutic Th1 response to HBV infection.