Patent ID: 9709511
Date: 2017-07-18
CPC Classifications: G01N,G01R,G16C

Claim:
1. A non-transitory computer-readable medium having stored thereon computer-executable instructions for isolating a chemical exchange saturation transfer (CEST), wherein, when a computer hardware arrangement executes the instructions, the computer arrangement is configured to perform procedures comprising: determining a first frequency based on a resonance frequency of a CEST agent and a second frequency that is outside a typical range of chemical shifts for observed nuclear spins; determining at least one of a main solvent or a medium for a sample; causing an irradiation on the sample with both the first and second frequencies using a magnetic resonance (MR) apparatus; receiving first data based on a first residual polarization of the irradiation of the sample with both the first and second frequencies; determining third and fourth frequencies that are located symmetrically to the first and second frequencies, respectively, based on a resonance frequency of the at least one of the main solvent or the medium, wherein the at least one of the main solvent or the medium includes a molecule with an exchangeable nuclei; causing an irradiation of the sample with both the third and fourth frequencies using the MR apparatus; receiving second data based on a second residual polarization of the irradiation of the sample with both the third and fourth frequencies; and determining third data related to a CEST contrast by subtracting the first data from the second data.