Patent ID: 9616034
Date: 2017-04-11
CPC Classifications: A61K,A61P

Claim:
1. A method for increasing bone mineral density (BMD) in a human male having or at risk for developing osteopenia or osteoporosis and at least 50 years of age with a body mass index (BMI) of at least 25 and a testosterone level below about 400 ng/dl, the method comprising administering to the subject a composition comprising trans-clomiphene or an analogue or pharmaceutically acceptable salt thereof, the composition being substantially free of cis-clomiphene, wherein the trans-clomiphene is administered in a daily amount of about 25 mg for a period of at least 6 months, whereby the serum level of CTX in the male is reduced by at least about 10% to 20% and the serum level of PINP in the human male is reduced by at least about 10% to 30%.