Patent ID: 9731026
Date: 2017-08-15
CPC Classifications: A61K

Claim:
1. An essentially water-free, low-transition-temperature mixture (LTTM) comprising at least one pharmaceutically active agent selected from the group consisting of a non-steroidal anti-inflammatory drug, a HMG-CoA reductase inhibitor, an analgesic, an antidepressant, an antipsychotic, an antihistamine, a mast cell stabilizer, a corticosteroid, a proton pump inhibitor, and combinations thereof, non-covalently bound to at least one pharmaceutically acceptable excipient, wherein the LTTM conforms to the stoichiometric formula: wherein A represents the pharmaceutically active agent; B and, optionally C, are pharmaceutically acceptable excipients capable of interacting with one of the other compounds in the LTTM, including A, through non-covalent bonds; and x, y, and z are independently selected from any number between about 0.25 to about 5, wherein the active agent is a hydrogen-bond donor or a hydrogen bond acceptor, wherein the LTTM comprises a hydrogen-bond donor and a hydrogen bond acceptor, and wherein the melting point of the LTTM is lower than the melting point of the pharmaceutically acceptable excipient(s), and the active agent alone.