Patent ID: 9579367
Date: 2017-02-28
CPC Classifications: A61K,A61P,C07D,C12N,C12Y

Claim:
1. An isolated and modified blood coagulation protein, said blood coagulation protein being from the vitamin K-dependent family and having a modified histidine (His) or serine (Ser) residue of the following formula: wherein: (aa) is lysine or alanine, PEG is 2-8 linear repeating units having the following formula where each carbon atom of said unit is optionally substituted, His/Ser is a histidine residue or a serine residue of the blood coagulation protein located within a serine protease active site, said His/Ser is covalently linked to the CH R is H or a residue of a natural or non-natural amino acid, n is an integer ranging from 2 to 4; and Y′ is wherein the blood coagulation protein is further defined as Factor Xa or Factor IIa.