Patent ID: 9616071
Date: 2017-04-11
CPC Classifications: A61K,A61P

Claim:
1. An oral sustained release pharmaceutical composition comprising: a plurality of granules having diameters of not more than 1000 μm, wherein said granules comprise: a nucleus granule comprised of beraprost sodium, and a coating agent comprising at least two skin layers of an outer layer and an inner layer which coat said nucleus granule, and wherein said outer layer comprises one or more relatively water-insoluble macromolecular substances selected from the group consisting of poly(ethylacrylate, methylmethacrylate), and poly(ethylacrylate, methylmethacrylate)trimethyl-ammonio-ethylmethacrylate chloride, and wherein said inner layer comprises a hot-melt low-melting substance selected from the group consisting of stearic acid, capric acid, lauric acid, myristic acid, palmitic acid, stearyl alcohol, myristyl alcohol, lauryl alcohol, cetyl alcohol, glyceryl palmitooleate, glyceryl monooleate, glyceryl monostearate, glyceryl monomyristate, glyceryl monobehenate, glyceryl trimyristate, glyceryl tribehenate, carnauba wax, and paraffins, wherein said composition provides a pH-independent release of said beraprost sodium.