Patent ID: 9611290
Date: 2017-04-04
CPC Classifications: A61K,A61P,C07D,C07K

Claim:
1. A method for therapeutic modulation of blood coagulation cascade or fibrinolysis, comprising administering to a patient in need thereof an effective amount of one or more compounds having the following formula: or a pharmaceutically acceptable salt thereof; wherein X is selected from the group consisting of H, CO 2 H, and CO 2 R′; n ranges from 0 to 3; and R is selected from the group consisting of phenyl, pyridyl, tetrazolyl, and piperidinyl; wherein R is unsubstituted or substituted by one or more substituents selected from the group consisting of halogen, R′, OR′, SR′, S═(O)R′, S(═O) 2 R′, S(═O) 2 NHR′, S(═O)2NR′ 2 , CN, NH 2 , NHR′, NR′ 2 , NHS(═O) 2 R′, NHC(═O)R′, NHC(═O)OR′, NHC(═O)NHR′, NHC(═O)NR′ 2 , C(═O)R′, C(═O)CH 2 OR′, CO 2 R′, C(═O)NHR′, and C(═O)NR′ 2 ; wherein when R is pyridyl it is optionally a pyridine N-oxide; and wherein each R′ is independently CF 3 or C 1 to C 4 lower alkyl or cycloalkyl.