Patent ID: 9540434
Date: 2017-01-10
CPC Classifications: A61K,A61P,C07K,G01N

Claim:
1. An isolated antibody, or an antigen binding fragment thereof, which recognizes and specifically binds to a phospho-epitope on the mammalian Tau protein or on a fragment thereof, wherein the mammalian Tau protein or fragment thereof comprises a phospho-epitope having, or within, the amino acid sequence VYKSPVVS (Tau aa 393-400 of SEQ ID NO: 67) comprising a phosphorylated Ser at position 396 (pS396), wherein said antibody comprises a light chain variable region comprising a CDR1 comprising the amino acid sequence of SEQ ID NO: 106, a CDR2 comprising the amino acid sequence of SEQ ID NO: 107, and a CDR3 comprising the amino acid sequence of SEQ ID NO: 108; and a heavy chain variable region comprising a CDR1 comprising the amino acid sequence of SEQ ID NO: 89, a CDR2 comprising the amino acid sequence of SEQ ID NO: 115, and a CDR3 comprising the amino acid sequence of SEQ ID NO: 91.