Patent ID: 9637552
Date: 2017-05-02
CPC Classifications: A01K,A61K,A61P,C07K,C12N,G01N

Claim:
1. A method for alleviating a symptom associated with a neurodegenerative condition, disease, or disorder mediated by a misfolded form of superoxide dismutase 1 (SOD1) in a subject in need of such alleviation, the method comprising administering to the subject a composition comprising a pharmaceutically acceptable vehicle and an immunogen that elicits production of an endogenous antibody that binds selectively and at least 2 fold more efficiently to an epitope on misfolded form of SOD1 compared to natively folded SOD1, wherein the immunogen comprises a polypeptide comprising up to 50 SOD1 residues, the polypeptide comprising: a) a peptide of at least 5 contiguous residues of any one of SEQ ID NO: 1-7, or b) a peptide as in a) comprising one or more oxidized or nitrated amino acids.