Patent ID: 9732084
Date: 2017-08-15
CPC Classifications: A61K,A61P,C07D

Claim:
1. A Conjugate having formula IV: wherein L is a Ligand unit selected from an antibody, an antigen-binding fragment of an antibody or a Fc fusion protein, LU is a Linker unit which is of formula 1a: wherein: -A wherein the asterisk indicates the point of attachment to L wherein the asterisk indicates the point of attachment to L wherein the asterisk indicates the point of attachment to L L p is 1 to 20; and D is a Drug unit of formula I: wherein R where A is a phenyl or a C X is selected from the group consisting of: O, S, C(═O), C(═O)O—, NH(C═O), NHNH, CONHNH,  NR and either: (i) Q (ii) Q R (iia) C (iib) C  wherein each of R  wherein one of R  where R R where R and R′ are independently selected from optionally substituted C either: (a) R (b) R (c) R R″ is a C Y and Y′ are selected from O, S, or NH; R