Patent ID: 9623144
Date: 2017-04-18
CPC Classifications: A61F,A61K,A61L,A61P,C08J

Claim:
1. An in vivo gelling pre-formulation for the treatment of retinal detachment, comprising: (a) multi-ARM nucleophilic polyol monomers having more than two nucleophilic arms, wherein each nucleophilic arm comprises a polyethyleneglycol chain and terminates in a nucleophilic amino group; wherein the nucleophilic arms of the multi-ARM nucleophilic polyol monomers are selected from and wherein n is 1-200; (b) multi-ARM electrophilic polyol monomers having more than two electrophilic arms, wherein each electrophilic arm comprises a polyethyleneglycol chain and terminates in an electrophilic succinimidyl group; wherein the electrophilic arms of the multi-ARM electrophilic polyol monomers are selected from (c) a viscosity enhancer selected from carboxymethylcellulose sodium, ethylcellulose, sodium alginate and mixtures thereof; wherein the viscosity of the in vivo gelling pre-formulation is between about 5 cP and 4000 cP; and wherein the in vivo gelling pre-formulation polymerizes and/or gels at a target site of an eye to form a biocompatible retinal patch.