Patent ID: 9670200
Date: 2017-06-06
CPC Classifications: A61K,A61P,C07D,C07F

Claim:
1. A method for sustained delivery of a tertiary amine-containing parent drug to a patient comprising administering a prodrug compound of the parent drug having the formula: wherein R Y is C(R X an optional biocompatible delivery system for delivering the prodrug wherein the system is capable of minimizing accelerated hydrolytic cleavage of the prodrug by minimizing exposure of the prodrug to water; wherein the prodrug compound has lower aqueous solubility at a reference pH as compared to the aqueous solubility of the parent drug at the same reference pH, wherein the reference pH is a pH at which the parent drug is fully protonated and wherein upon administration to the patient, release of the parent drug from the prodrug is sustained release and wherein the parent drug is present in the blood stream of the patient for a period of at least one week.