Patent ID: 9732339
Date: 2017-08-15
CPC Classifications: A61K,A61P,C12N,C12Q

Claim:
1. A synthetic, modified oligonucleotide of 10 to 30 nucleotides in length comprising at least one modification wherein the at least one modification is selected from: at least one modified sugar moiety; at least one modified intemucleotide linkage; at least one modified nucleotide, and combinations thereof; wherein said oligonucleotide is an antisense compound which specifically hybridizes and is at least 95% complementary to a complementary 10 to 30 nucleotide region on a natural antisense polynucleotide of the p63 gene, wherein said natural antisense polynucleotide is selected from SEQ ID NO: 2 and upregulates the function and/or expression of a Tumor Protein 63 (p63) gene in vivo or in vitro as compared to a normal control.