Patent ID: 9717779
Date: 2017-08-01
CPC Classifications: A61K,A61L,C08L

Claim:
1. An implantable matrix configured to fit at or near a target tissue site, the matrix comprising: a biodegradable material and a ligand in a Tris buffer bound to the matrix and configured to bind to a receptor and allow influx of cells into the matrix, wherein the ligand is uniformly disposed throughout the matrix in an amount of 0.4 mg/ml to 10.0 mg/ml so that the ratio of ligand to receptor is from about 0.5 to about 1.5, and the matrix releases the ligand at a rate of 0.2 ng/ml/hour to 20 ng/ml/hour; wherein the ligand is bone morphogenetic protein-2; wherein the matrix is porous, and at least 50% of the pores have a pore size between 10 μm and 500 μm; wherein the matrix has a density of 1.6 g/cm wherein the matrix comprises elongated particles; and wherein the matrix further comprises a metalloprotease that reduces degradation of the ligand.