Patent ID: 9567397
Date: 2017-02-14
CPC Classifications: C07K

Claim:
1. An isolated antibody comprising: (i) a heavy chain variable region comprising complementarity determining regions CDR1, CDR2, and CDR3 of SEQ ID NOs: 1, 2, and 3, or variants thereof; and (ii) a light chain variable region comprising complementarity determining regions CDR1, CDR2, and CDR3 of SEQ ID NOs: 4, 5 and 6, or variants thereof, with the proviso that the amino acid phenylalanine in the light chain CDR3 of SEQ ID NO:6 is not substituted, which phenylalanine is at position 93 of the light chain variable region according to the numbering of Kabat et al, wherein the variants of the heavy chain variable region, the light chain variable region, or of both the heavy chain variable region and the light chain variable region have one or more amino acids selected from the amino acid wherein the amino acid positions in the heavy chain CDR2, the light chain CDR1, and the light chain CDR2 are according to the numbering of Kabat et al, or an antigen-binding fragment thereof, and wherein said antibody binds to human GM-CSF, and the antibody or antigen binding fragment thereof has an affinity to the human GM-CSF T117 and I117 alleles that differ by a factor of less than 5.