Patent ID: 9536041
Date: 2017-01-03
CPC Classifications: C12Q,G16B

Claim:
1. A method of characterizing a first single-molecule DNA, comprising: labeling a plurality of sequence-specific locations on the first single-molecule DNA with a labeling technique that does not comprise labeling a cut or nicked strand of the first single-molecule DNA; linearizing at least a portion of the labeled first single-molecule DNA in a nanochannel by physical-entropic confinement of the first single-molecule DNA; and detecting a recognizable pattern of label positions on the linearized first single-molecule DNA or portion thereof in the nanochannel, wherein said detecting comprises simultaneously detecting genomic sequence information and epigenomic pattern information in the same field of view on the linearized first single-molecule DNA or portion thereof, wherein said detecting comprises detecting at least one of a fluorescent signal, a chemoluminescent signal, an electromagnetic signal, an electrical signal, or a potential difference, and wherein detecting said genomic sequence information comprises detecting a signal, wavelength, or signal and wavelength different from detecting said epigenomic pattern information.