Patent ID: 9623094
Date: 2017-04-18
CPC Classifications: A61K,A61P,C12N

Claim:
1. A method of preparing an immunogenic substance suitable for oral or nasal vaccination, wherein the immunogenic substance consists of a vaccine, a crosslinked mucoadhesive polymer, one or more sugars, one or more oligosaccharides and one or more electrolytes, wherein the one or more sugars are selected from the group consisting of fructose, sucrose, dextrose, and trehalose, wherein the one or more oligosaccharides are selected from the group consisting of inulin and frutcoologosaccharides (FOS), and wherein the mucoadhesive polymer is a polymer that is not a dimer, the method comprising: (a) dissolving a mucoadhesive polymer and the one or more oligosaccharides in an aqueous solution; (b) mixing the vaccine with the resulting solution from step (a) to form a slurry; (c) cross-linking the mucoadhesive polymer in the slurry with the one or more electrolytes to form hydrogel particles; (d) soaking the hydrogel particles in a solution saturated with one or more sugars to make semi-dry particles; and (e) drying the semi-dry particles, whereby the immunogenic substance is formed.