Patent ID: 9714291
Date: 2017-07-25
CPC Classifications: C07K

Claim:
1. A heterodimer protein that is (i) a heterodimer protein composed of a first polypeptide comprising a heavy chain variable region (VH) and an immunoglobulin G (IgG)1 heavy chain constant region (CH), and a second polypeptide comprising a light chain variable region (VL) and a fusion polypeptide (CL-Fc) prepared by fusion of a light chain constant region (CL) and an Fc region of IgG1, wherein the heterodimer protein has a modification selected from the group consisting of: (ii) a heterodimer protein composed of a first polypeptide comprising a VH and an IgG4 CH, and a second polypeptide comprising a VL and a CL-Fc prepared by fusion of a CL and an Fc region of IgG4, wherein the heterodimer protein has a modification selected from the group consisting of: wherein in (i) and (ii), the VH of the first polypeptide and the VL of the second polypeptide forms a binding domain.