Patent ID: 9573985
Date: 2017-02-21
CPC Classifications: A61K,A61P,C07K

Claim:
1. A recombinant or synthetic p16 protein variant comprising a p16 protein in which at least one hydrophobic amino acid residue that is exposed on the tertiary structure of the p16 protein in aqueous solution is substituted with a hydrophilic amino acid, wherein the hydrophobic amino acid is leucine (L), cysteine (C), valine (V), phenyl alanine (F), tryptophan (W), isoleucine (I), proline (P), methionine (M), or a combination thereof; and the hydrophilic amino acid is lysine (K), aspartic acid (D), glutamic acid (E), glutamine (Q), asparagine (N), serine (S), alanine (A), threonine (T), arginine (R), or a combination thereof.