Patent ID: 9693958
Date: 2017-07-04
CPC Classifications: A61K,A61P,C12N,Y10S

Claim:
1. A method for preparing lipid nanoparticles (LNP), the method comprising: a) introducing i) one or more streams of a lipid solution via a first set of one or more inlet ports of a manifold and ii) one or more streams of an aqueous solution via a second set of one or more an inlet ports of the manifold, thereby mixing the lipid solution and the aqueous solution so as to produce an LNP solution; and b) recovering the LNP solution via one or more outlet ports of the manifold; wherein the angle between at least one lipid and at one aqueous solution inlet ports is not 180° or a substantially similar angle, wherein the flow velocity of the LNP solution is at least about 0.2 m/s and the flow rate is at least 50 ml/minute, and wherein the lipid solution comprises lipids dissolved in an organic solvent.