Patent ID: 9730965
Date: 2017-08-15
CPC Classifications: A61K,A61P

Claim:
1. A composition for bone regeneration, comprising: an isolated population of perivascular stem cells (PSC), and an osteoinductive agent, wherein the osteoinductive agent is in a therapeutically effective amount for causing the isolated population of PSC to differentiate in the osteoblast lineage or in a therapeutically effective amount for enhancing the survivability or engraftment of the isolated population of PSC where the PSC provide trophic factors or enhance vascular ingrowth, and wherein the PSC are selected from the group consisting of adventitial cells showing positive expression of CD34; adventitial cells showing positive expression of CD34 and negative expression of CD146, NG2, PDGF-β, CD45 and CD31; adventitial cells showing positive expression of CD34 and negative expression of CD146, CD45 and CD31; adventitial cells showing positive expression of CD34 and negative expression of CD146 and CD31; and a combination thereof.