Patent ID: 9551720
Date: 2017-01-24
CPC Classifications: G01N

Claim:
1. A method of treating, comprising: a) collecting at least one urine sample from a patient within fourteen days of exhibiting an acute renal injury, wherein said patient is asymptomatic of a renal disease; b) expressing a plurality of renal injury protein biomarker nucleic acids from said at least one urine sample with a proteomics platform to create a signature expression profile, said profile comprising a renal injury protein biomarker panel; c) detecting a plurality of overexpressed renal injury protein biomarkers and a plurality of underexpressed renal injury protein biomarkers from said renal injury biomarker panel when compared to a renal recovery group comprising individuals without an acute renal injury, d) creating a probability value of non-recovery for said patient from said acute renal injury by a combination of receiver operated characteristic area under the curve determinations for said plurality of detected overexpressed renal injury biomarkers and said plurality of detected underexpressed renal injury biomarkers as compared to a plurality of diagnostic threshold values, wherein said acute renal injury recovery is determined by an improved renal function; e) treating said patient during the development of said renal disease with a treatment regimen selected from the group consisting of: i) said treatment regimen comprising adverse effects when said probability value of non-recovery from said acute renal injury is greater than 50%, and ii) said treatment regimen without adverse effects when said probability value of non-recovery from said acute renal injury is less than 50%.