Patent ID: 9675820
Date: 2017-06-13
CPC Classifications: A61B,A61M,A61N,G01S

Claim:
1. A method for enhancing stable cavitation during sonothrombolysis, comprising: administering a nucleating agent and a thrombolytic agent to a target treatment zone of a patient; providing a determined level of ultrasonic energy throughout the target treatment zone of the patient, wherein the determined level of ultrasonic energy is produced by a source transducer and comprises a fundamental ultrasonic frequency, wherein the determined level of ultrasonic energy is provided in intervals separated by rest periods, each interval lasting for an interval duration and each rest period lasting for a rest period duration, wherein no ultrasonic energy is provided during the rest periods; detecting a scattered level of ultrasonic energy with a detector transducer, wherein the scattered level of ultrasonic energy is received by the detector transducer and comprises a derivative frequency of the fundamental ultrasonic frequency selected from the group consisting of a subharmonic frequency, an ultraharmonic frequency, and combinations thereof; and modifying the intervals and rest periods to maintain stable cavitation by leaving the source transducer on when scattered ultrasonic waves of the derivative frequency are detected, and initiating a rest period when scattered ultrasonic waves of the derivative frequency decrease or are not detected.