Patent ID: 9540650
Date: 2017-01-10
CPC Classifications: A61K,A61P,C12N,C12Q,G01N

Claim:
1. A transcribable or replicable nucleic acid aptamer comprising: natural nucleotides and non-natural nucleotides having an artificial base-pairable artificial base, wherein the artificial base is selected from the group consisting of 7-(2-thienyl)-3H-imidazo[4,5-b]pyridin-3-yl, 2-nitropyrrol-1-yl, and 2-formyl-1H-pyrrol-1-yl, and wherein the nucleic acid aptamer is directed against interferon γ as a target substance, wherein the nucleic acid aptamer comprises any one nucleotide sequence selected from the group consisting of SEQ ID NOs: 167 to 174 (provided that “n” in the sequences represents 7-(2-thienyl)-3H-imidazo[4,5-b]pyridin-3-yl), 186, 188, 190, 192, 194, 214 to 222, and 279 to 328.