Patent ID: 9603941
Date: 2017-03-28
CPC Classifications: A61K

Claim:
1. A method of preparing a dendritic drug, the method comprising: (I) providing a therapeutically active multifunctional drug, said drug having at least one reactive group capable of providing a linker site, said drug having at least one functional group capable of providing a starting point for the preparation of a dendritic structure; (II) chemically protecting any reactive group in the drug that is not capable of providing a linker site or providing a starting point for the preparation of a dendritic molecule; (III) chemically protecting any reactive groups capable of providing a linker site; (IV) chemically protecting any functional group capable of providing a starting point for the preparation of a dendritic molecule; (V) deprotecting any group formed in (III); (VI) reacting any group formed in (V) with a first linker group selected from the group consisting of: (VII) reacting the first linker from (VI) with a second linker group selected from the group consisting of: (VIII) coupling two units formed in (VI) through the first linker groups; (IX) deprotecting the groups formed in (IV) to yield a core molecule for the dendritic drug; (X) reacting a predetermined amount of the molecules formed in (VI) with each one equivalent of the molecule formed in (VIII), and deprotecting the protected groups formed in (IV); (XI) deprotecting any group in the molecule that is not capable of providing a linker site or providing a starting point for the preparation of a dendritic molecule to give a first generation dendritic drug.