Patent ID: 9534195
Date: 2017-01-03
CPC Classifications: C12M,C12N

Claim:
1. A bioreactor for facilitating and supporting cellular functions and/or the generation of tissue constructs, said bioreactor comprising; a bioreactor housing; one or more ports for media flow; at least one chamber defined within said bioreactor housing for facilitating and supporting cellular functions and/or the generation of one or more tissue constructs from cell and/or tissue sources; and one or more sensors for monitoring and automatically adjusting parameters related to said cellular functions and/or generation of tissue constructs within said at least one chamber, the parameter selected from the group consisting of temperature, pH, dissolved gases selected from oxygen and carbon dioxide, metabolic turnover inclusive of lactic acid and glucose consumption, optical density, light scattering, and images of cell/tissue proliferation, wherein: the bioreactor is adapted to automatically monitor parameters relayed by the one or more sensors such that optimal conditions are maintained in the bioreactor and to automatically re-adjust the parameters in the bioreactor responsive to the status of cell proliferation and/or tissue formation to generate a desired cell population and/or tissue construct in the bioreactor.