Patent ID: 9545361
Date: 2017-01-17
CPC Classifications: A61J,A61K,B01F

Claim:
1. A method of melt-blending a composition of two or more ingredients comprising one or more crystalline, thermolabile active pharmaceutical ingredients (API's) and one or more pharmaceutically acceptable excipients or carriers, wherein a thermokinetic compounding of the ingredients takes place when the ingredients are heated by way of being processed at high rotational speeds of shaft extensions on a motor driven shaft in a mixing chamber of a thermokinetic mixer, whereby the resulting composition forms a melt blended pharmaceutical composition with a substantially higher amorphosity and reduced crystallinity of the API's than in the original ingredients, the method additionally comprising operating the motor driven shaft for a first time period at a first lower speed until achieving a predetermined parameter, at which time the shaft speed is adjusted to a second higher speed for a second time period, wherein the mixing process is uninterrupted between the first and second time periods.