Patent ID: 9640375
Date: 2017-05-02
CPC Classifications: G01N,G16B,G16C,H01J

Claim:
1. A method for determining low mass ions for diagnosing colorectal cancer (CRC) in a mammal, the method comprising steps of: (a) taking low mass ion mass spectra from a plurality of biological samples of a plurality of mammals wherein the biological samples being prepared by a chemical extracting step, using a mass spectrometer and extracting peak intensities of low mass ions from the low mass ion mass spectra; (b) performing a biostatistical analysis on the acquired peak intensities to calculate a discriminant score (DS) for each peak; (c) primarily selecting peaks of the respective cases from among the peaks, in which the primarily selected peaks meet a condition that an absolute value of a product of the peak intensities multiplied by factor loadings of the respective peaks exceeds T (d) secondarily selecting peaks from the primarily selected peaks for the respective cases, in which the secondarily selected peaks are commonly present in the cases which are T (e) determining a group of low mass ions for diagnosing CRC with the peaks selected at the step (d) wherein after the step (d), the discriminant score (DS) is calculated only with the peaks selected at the step (d) so that sensitivity and specificity are calculated according to the calculated DS, and if the calculated sensitivity is less than N