Patent ID: 9555035
Date: 2017-01-31
CPC Classifications: A61K,A61N,A61P,C07D

Claim:
1. A method for inhibiting a MEK kinase, said method comprising: administering a composition to an individual in need of said inhibiting; wherein the composition comprises an effective amount of a compound of formula I and optionally one or more pharmaceutically acceptable carriers, diluents, or excipients; and wherein the compound of formula I is represented by the following structure wherein: R R R R R R R with the provisos that both R when R R R m is an integer selected from the group consisting of 1, 2, 3, and 4; further wherein: when the alkyl group or alkenyl group is substituted, the alkyl group or alkenyl group is substituted with 1 to 4 substituents independently selected from the group consisting of oxo, halogen, nitro, cyano, perhaloalkyl, cycloalkyl, aryl, heteroaryl, heterocyclyl, —OR when the cycloalkyl group or cycloalkenyl group is substituted, the cycloalkyl group or cycloalkenyl group is substituted with 1 to 3 substituents independently selected from the group consisting of oxo, halogen, nitro, cyano, alkyl, alkenyl, perhaloalkyl, hydroxyalkyl, aryl, heteroaryl, heterocyclyl, —OR when the aryl group is substituted, the aryl group is substituted with 1 to 3 substituents independently selected from the group consisting of halogen, nitro, cyano, hydroxy, alkyl, alkenyl, perhaloalkyl, cycloalkyl, cycloalkenyl, heterocycle, —O-alkyl, —O— perhaloalkyl, —N(alkyl)alkyl, —N(H)alkyl, —NH when the heteroaryl group is substituted, the heteroaryl group is substituted with 1 to 3 substituents independently selected from the group consisting of halogen, nitro, cyano, hydroxy, alkyl, alkenyl, perhaloalkyl, cycloalkyl, cycloalkenyl, heterocycle, —O-alkyl, O-perhaloalkyl, —N(alkyl)alkyl, —N(H)alkyl, —NH when the heterocyclyl group is substituted, the heterocyclyl group is substituted with 1 to 3 substituents, when the heterocyclic group is substituted on a ring carbon of the ‘heterocycle’, the substituents are independently selected from the group consisting of halogen, nitro, cyano, oxo, alkyl, alkenyl, perhaloalkyl, cycloalkyl, cycloalkenyl, aryl, heteroaryl, heterocyclyl, —OR when the heterocyclic group is substituted on a ring nitrogen of the ‘heterocycle’, the substituents are independently selected from the group consisting of alkyl, alkenyl, cycloalkyl, cycloalkenyl, aryl, heteroaryl, —SO when the heterocyclic group is substituted on a ring sulfur of the ‘heterocycle’, the sulfur is substituted with 1 or 2 oxo groups; R R R wherein the compound of formula I includes a tautomeric form thereof, a stereoisomeric form thereof, or a pharmaceutically acceptable salt thereof.