Patent ID: 9629839
Date: 2017-04-25
CPC Classifications: A61K,A61P,C12N,C12Q,C12Y,G01N

Claim:
1. A method of treating a subject having cancer, the cancer comprising a mutant C-RAF polypeptide, the method comprising: (a) extracting nucleic acid from a sample of cells of the subject; (b) assaying at least a portion of a nucleic acid molecule encoding a C-RAF polypeptide from the sample to identify the presence of a mutation in a nucleic acid molecule encoding a mutant C-RAF polypeptide having a 257S>P mutation as compared to a wild type C-RAF polypeptide of SEQ ID NO: 2; and (c) administering an effective amount of a RAF inhibitor and an effective amount of a MEK inhibitor to the subject having the cancer comprising the mutant C-RAF polypeptide, the sample having the nucleic acid molecule that includes nucleotides that alter the amino acid residue at position 257 of the encoded mutant C-RAF polypeptide.