Patent ID: 9599604
Date: 2017-03-21
CPC Classifications: C12M,G01N,Y10T

Claim:
1. A device comprising: a first plate and a second plate defining a flow chamber between the plates, the first plate configured to hold an independent substrate comprising a sample and comprising a securing structure for securing the substrate within the flow chamber, and the second plate comprising an integrated, recessed, optically transparent viewing window, a top surface of the viewing window being recessed below a top surface of the second plate and defining a recessed area in the second plate, and a bottom surface of the viewing window forming a portion of the flow chamber adjacent the sample to allow viewing of the sample through the viewing window; a first inlet port at a first end of the device that is configured to flow a first fluid; a flow channel within the flow chamber defined in part by the second plate and in part by the first plate, the substrate, or both, wherein the flow channel is in fluidic communication with the first inlet port and is configured so the first fluid contacts a side of the sample adjacent the viewing window and the sample is viewed through the optically transparent viewing window in real time as the sample is exposed to the first fluid; and an exit port that is in fluidic communication with the flow channel, wherein the flow channel is configured so that the first fluid flows from the first inlet port side to the exit port side of the flow channel.