Patent ID: 9738716
Date: 2017-08-22
CPC Classifications: A61K,A61P,C07K,G01N

Claim:
1. An antibody or binding fragment thereof that (i) binds to an epitope of human beta klotho and cynomologous monkey beta klotho recognized by an antibody comprising a heavy chain variable region having the amino acid sequence of SEQ ID NO:25 and a light chain variable region having the amino acid sequence of SEQ ID NO:26; or (ii) competes for the binding to human beta klotho with an antibody comprising a heavy chain variable region having the amino acid sequence of SEQ ID NO:25 and a light chain variable region having the amino acid sequence of SEQ ID NO:26, wherein the antibody or binding fragment comprises all three heavy chain complementarity determining regions (CDRs) and all three light chain CDRs from: (a) an antibody that comprises a VH sequence that is SEQ ID NO:25 and a VL sequence that is SEQ ID NO:26; (b) an antibody that comprises a VH sequence that is SEQ ID NO:51 and a VL sequence that is SEQ ID NO:52; (c) an antibody that comprises a VH sequence that is SEQ ID NO:77 and a VL sequence that is SEQ ID NO:78; (d) an antibody that comprises a VH sequence that is SEQ ID NO:103 and a VL sequence that is SEQ ID NO:104; (e) an antibody that comprises a VH sequence that is SEQ ID NO:129 and a VL sequence that is SEQ ID NO:130; (f) an antibody that comprises a VH sequence that is SEQ ID NO:155 and a VL sequence that is SEQ ID NO:156; (g) an antibody that comprises a VH sequence that is SEQ ID NO:181 and a VL sequence that is SEQ ID NO:182; (h) an antibody that comprises a VH sequence that is SEQ ID NO:207 and a VL sequence that is SEQ ID NO:208; (i) an antibody that comprises a VH sequence that is SEQ ID NO:233 and a VL sequence that is SEQ ID NO:234; or (j) an antibody that comprises a VH sequence that is SEQ ID NO:259 and a VL sequence that is SEQ ID NO:260.