Patent ID: 9598697
Date: 2017-03-21
CPC Classifications: A61K,C12N,C12R

Claim:
1. A recombinant Salmonella bacterium, wherein the bacterium has: a. ΔP b. at least one mutation selected from the group consisting of ΔP c. constitutive expression, from a constitutive promoter, of at least one nucleic acid selected from the group consisting of tar and tsr, d. a deletion or mutation to decrease expression of trg, e. constitutive expression, from a constitutive promoter, of hilA, f. at least one mutation selected from the group consisting of ΔpurA and Δ(wza-wcaM), g. regulated delayed synthesis of at least one nucleic acid selected from the group consisting of sopE2 and sopB, and h. increased expression of at least one nucleic acid selected from the group consisting of sseL tlpA, and avrA and/or expression of at least one protein selected from the group consisting of Fas ligand (FasL) and tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL).