Patent ID: 9670284
Date: 2017-06-06
CPC Classifications: A61K,A61P,C07K

Claim:
1. A method of treating diabetic nephropathy in a patient, comprising administering to a patient in need thereof, an effective amount of a VEGFR1 antibody, wherein the VEGFR1 antibody is an antibody comprising a light chain variable region (LCVR) and a heavy chain variable region (HCVR), wherein the LCVR comprises the complementarity determining regions (CDRs) LCDR1, LCDR2, and LCDR3, and the HCVR comprises the CDRs HCDR1, HCDR2, and HCDR3, wherein the LCDR1 is the polypeptide consisting of the amino acid sequence of RASQSVSSSYLA (SEQ ID NO: 8), the LCDR2 is the polypeptide consisting of the amino acid sequence of GASSRAT (SEQ ID NO: 9), the LCDR3 is the polypeptide consisting of the amino acid sequence of QQYGSSPLT (SEQ ID NO: 10), the HCDR1 is the polypeptide consisting of the amino acid sequence of GFAFSSYGMH (SEQ ID NO: 2), the HCDR2 is the polypeptide consisting of the amino acid sequence of VIWYDGSNKYYADSVRG (SEQ ID NO: 3), and the HCDR3 is the polypeptide consisting of the amino acid sequence of DHYGSGVHHYFYYGLDV (SEQ ID NO: 4).