Patent ID: 9573944
Date: 2017-02-21
CPC Classifications: A61K,A61N,A61P,C07D

Claim:
1. A compound of formula I, its tautomeric forms, its pharmaceutically acceptable salts, their combinations with suitable medicament and pharmaceutical compositions containing them, wherein, R R R R R R R R E is substituted- or unsubstituted-four membered heterocyclic ring, wherein the substituents are selected from the group consisting of alkyl, halogen, —C(═O)OR R R R R n is an integer selected from the group consisting of 0, 1 and 2; p is an integer selected from the group consisting of 0 and 1; when the alkyl group and alkenyl group is substituted, the alkyl group and alkenyl group is substituted with 1 to 4 substituents independently selected from the group consisting of oxo, halogen, nitro, cyano, perhaloalkyl, cycloalkyl, aryl, heteroaryl, heterocyclyl, —OR when the cycloalkyl group and cycloalkenyl group is a substituted, the cycloalkyl group and cycloalkenyl group is substituted with 1 to 3 substituents independently selected from the group consisting of oxo, halogen, nitro, cyano, alkyl, alkenyl, perhaloalkyl, aryl, heteroaryl, heterocyclyl, —OR when the aryl group is a substituted, the aryl group is substituted with 1 to 3 substituents independently selected from the group consisting of halogen, nitro, cyano, hydroxy, alkyl, alkenyl, perhaloalkyl, cycloalkyl, cycloalkenyl, heterocycle, —O-alkyl, —O-perhaloalkyl, —N(alkyl)alkyl, —N(H)alkyl, —NH when the heteroaryl group is a substituted, the heteroaryl group is substituted with 1 to 3 substituents independently selected from the group consisting of halogen, nitro, cyano, hydroxy, alkyl, alkenyl, perhaloalkyl, cycloalkyl, cycloalkenyl, heterocycle, —O-alkyl, O-perhaloalkyl, —N(alkyl)alkyl, —N(H)alkyl, —NH when the heterocyclyl group is a substituted, the heterocyclyl group is substituted with 1 to 3 substituents, when the heterocyclic group is substituted on a ring carbon of the ‘heterocycle’, the substituents are independently selected from the group consisting of halogen, nitro, cyano, oxo, alkyl, alkenyl, perhaloalkyl, cycloalkyl, cycloalkenyl, aryl, heteroaryl, heterocyclyl, —OR when the heterocyclic group is substituted on a ring nitrogen of the ‘heterocycle’, substituents are independently selected from the group consisting of alkyl, alkenyl, cycloalkyl, cycloalkenyl, aryl, heteroaryl, —SO R R R