Patent ID: 9725756
Date: 2017-08-08
CPC Classifications: A61K,A61P,C12N,C12Q

Claim:
1. A synthetic, oligonucleotide of 15-25 nucleotides in length having at least one modification wherein the at least one modification is selected from: at least one modified sugar moiety; at least one modified internucleotide linkage; at least one modified nucleotide, and combinations thereof; wherein said oligonucleotide is an antisense compound which is 100% complementary to and specifically hybridizes to a complementary 15-25 nucleotide region of a natural antisense polynucleotide of a ‘C terminus of HSP70-Interacting Protein (CHIP) polynucleotide having SEQ ID NOS: 2 or 3 and upregulates the function and/or expression of a ‘C terminus of HSP70-Interacting Protein’ (CHIP) gene in vivo or in vitro as compared to a normal control.