Patent ID: 9724319
Date: 2017-08-08
CPC Classifications: A61K,A61P

Claim:
1. A composition comprising: a) an amount of leucine in the form of a free amino acid, and/or an amount of a metabolite thereof; b) an amount of metformin; and c) an amount of sildenafil; wherein the metabolite thereof is selected from the group consisting of β-hydroxy β-methylbutyrate (HMB) and keto-isocaproic acid (KIC), wherein the amount of leucine and/or a metabolite thereof is about 50-95 wt % of the total wt of (a), (b), and (c), the amount of metformin is about 5-50 wt % of the total wt of (a), (b), and (c), and the amount of sildenafil is 0.1 to 10 mg and about 0.01-1 wt % of the total wt of (a), (b), and (c), wherein the composition is formulated for administration to a subject in need thereof, wherein (a), (b) and (c) are co-administered, and wherein the composition is substantially free of free amino acids selected from the group consisting of alanine, arginine, asparagine, aspartic acid, cysteine, glutamic acid, glutamine, glycine, histidine, isoleucine, lysine, methionine, phenylalanine, proline, serine, threonine, tryptophan, tyrosine, and valine.