Patent ID: 9649382
Date: 2017-05-16
CPC Classifications: A61K,A61Q

Claim:
1. A pre-formulation comprising a low viscosity mixture of: a) 30 to 89% of glycerol dioleate (GDO) and/or a tocopherol; b) 10 to 60% of at least one phosphatidylcholine (PC); c) 1 to 30% of solvent selected from ethanol, N-methyl pyrrolidone (NMP), and/or isopropanol; including at least one bioactive agent is dissolved or dispersed in the low viscosity mixture, said bioactive agent being selected from the group consisting of: corticosteroids, nonsteroidal anti-inflammatory compounds, local inhibitors of inflammatory pathways, phospholipase inhibitors, anti-infectives, cytokines and cytokine inducers/suppressors; wherein the pre-formulation has a viscosity of 1 to 1000 mPas at 20° C.; and wherein the pre-formulation forms at least one liquid crystalline phase structure upon contact with an aqueous fluid and/or body surface.