Patent ID: 9649374
Date: 2017-05-16
CPC Classifications: A61K,A61P,C07K

Claim:
1. Antibody 006-H08, 006-H08-12-2, 006-H08-13-2, 006-H08-13-6-1, 006-H08-14-6-0, 006-H08-15-5, 006-H08-19-1, 006-H08-29-1, 006-H08-32-2, 006-H08-33-0, 006-H08-33-16-0, 006-H08-35-17-1, 006-H08-35-17-4, 006-H08-35-1, 006-H08-36-17-0, 006-H08-37-19-0, 006-H08-39-7, 006-H08-48-5, 006-H08-53-27-0, 006-H08-59-30-0, 006-H08-63-32-4, 006-H08-65-33-2, or 006-H08-68-35-2 or an antigen-binding fragment thereof, which antigen-binding fragment antagonizes prolactin receptor-mediated signaling and which binds to an epitope of the extracellular domain (ECD) of the prolactin receptor PRLR or to the ECD of polymorphic variant I146L of PRLR or to the ECD of polymorphic variant I76V of PRLR, the amino acid sequence of the ECD of PRLR corresponding to SEQ ID NO: 70.