Patent ID: 9694055
Date: 2017-07-04
CPC Classifications: A61K,A61L,A61P

Claim:
1. A method of inducing renal progenitor cell recruitment to the kidney parenchyma of a subject comprising: obtaining a substantially cell-free biocompatible collagen thermogel that will thermogel as it reaches body temperature and maintain a viscosity greater than water for more than 1 hour when gelled; chilling the substantially cell-free biocompatible collagen thermogel below its gelation temperature; injecting the chilled, substantially cell-free biocompatible collagen thermogel into the kidney parenchyma of the subject with an injection needle; measuring the pressure in the kidney parenchyma during injection with a pressure sensor; continuing injection of the chilled, substantially cell-free biocompatible collagen thermogel until a positive pressure in a range from about 5 cmH20 to about 20 cmH20 in the kidney parenchyma is obtained by the injecting step; maintaining the positive pressure for at least one hour after injection due to gelation of the substantially cell-free biocompatible collagen thermogel as it reaches body temperature; and creating a hyperbaric environment caused by the step of injecting the substantially cell-free biocompatible collagen thermogel into the kidney parenchyma, whereby renal progenitor cells are recruited to the kidney parenchyma.