Patent ID: 9534014
Date: 2017-01-03
CPC Classifications: A61K,A61P,C07C,C07D,C07K

Claim:
1. A pharmaceutical composition, which comprises a trypsin inhibitor and a compound of general formula (II): or a pharmaceutically acceptable salt thereof, in which: X represents a residue of a phenolic opioid selected from the group consisting of buprenorphine, dihydroetorphine, diprenorphine, etorphine, hydromorphone, levorphanol, morphine, nalmefene, naloxone, N-methylnaloxone, naltrexone, N-methylnaltrexone, oxymorphone, oripavine, ketobemidone, dezocine, pentazocine, phenazocine, butorphanol, nalbuphine, meptazinol, O-desmethyltramadol, tapentadol, and nalorphine, wherein the hydrogen atom of the phenolic hydroxyl group is replaced by a covalent bond to —C(O)—NR R each R each R or R n represents an integer from 2 to 4; R R