Patent ID: 9737552
Date: 2017-08-22
CPC Classifications: A61K,A61P

Claim:
1. A method of treating cognitive impairment in a subject who has multiple sclerosis (MS), the method comprising the steps of: (a) performing magnetic resonance spectroscopy (MRS) to detect a concentration of N-acetylaspartylglutamate (NAAG) in the brain of the subject that is less than 84% of the mean NAAG concentration in the brain of a healthy subject, or a concentration of NAAG in a region of the brain of less than 3.1 mM in the hippocampus or less than 1.9 mM in the frontal white matter; and (b) administering to the subject an inhibitor of glutamate carboxypeptidase II (GCPII).