Patent ID: 9567585
Date: 2017-02-14
CPC Classifications: C12N

Claim:
1. An antisense oligonucleotide of 16-50 nucleotides in length comprising a sequence that permits specific hybridization to a target region of a human 5′-HT2C receptor (HTR2C) pre-mRNA under stringent conditions, wherein: the target region comprises a nucleotide sequence 5′ UUGGCCAUAAGAAUUGCAGCGGCUAUGCUCAAUACU 3′ (SEQ ID NO: 1) and; the antisense oligonucleotide comprises a sequence at least 95% identical to 18 or more contiguous nucleotides that appear in: 5′ AGUAUUGAGCAUAGCCGCUGCAAUUCUUAUGGCCAA 3′ (SEQ ID NO: 15) and the antisense oligonucleotide comprises a ribose group modified with a methyl group; further wherein the antisense oligonucleotide, once administered to a cell, modulates 5′HT2C receptor (HTR2C) activity.