Patent ID: 9649284
Date: 2017-05-16
CPC Classifications: A61K,A61P

Claim:
1. A method of treating pain in critically ill patients in need thereof, comprising administering to critically ill patients a dosage regimen of an intravenous ibuprofen pharmaceutical composition comprising from about 400 mg to about 800 mg ibuprofen about every 4 to about 6 hours which attains (i) a mean Cmax from about 20.8 μg/ml to about 75 μg/ml; (ii) a mean AUC from about 36.8 μg.h/ml to about 117.5 μg.h/ml; or (iii) both (i) and (ii); wherein the critically ill patients are not being treated for inflammation and are receiving at least one of the following: vasopressor support treatment, mechanical ventilation treatment, large volumes of blood products; multiple antibiotics; have a pulmonary artery catheter treatment, an arterial blood pressure catheter treatment, inserted; are being treated in an Intensive Care Unit; packed red blood cells administration, undergoing veno-venous hemofiltration, and multiple antibiotics administration; and pain is thereby treated.