Patent ID: 9717778
Date: 2017-08-01
CPC Classifications: A61K,A61P

Claim:
1. A method for treatment or prevention of a disease caused by and/or associated withan increased level of insulin-like growth factor I (IGF-I) the method comprising administering to a subject in need thereof, a growth hormone (GH) variant having GH antagonistic activity and comprising the following amino acid substitutions: H18D, H21N, G120K, R167N, K168A, D171S, K172R, E174S, I179T compared with the native GH amino acid sequence shown in SEQ ID NO:2, in combination with an oligonucleotide 15 to 30 nucleobases in length comprising at least one modified internucleoside linkage, sugar moiety, or nucleobase, targeted to a nucleic acid encoding human growth hormone receptor (GHR) so as to inhibit expression of the GHR, thereby reducing the level of IGF-I in the subject, wherein the disease caused by and/or associated with an increased level of IGF-I is acromegaly, diabetic retinopathy, diabetic nephropathy, or an IGF-I positive cancer such as prostate, myeloma, lung, breast or colon cancer.