Patent ID: 9629787
Date: 2017-04-25
CPC Classifications: A61K,A61Q,C07C

Claim:
1. A method of preparing an N-acyl acidic amino acid or a salt thereof, comprising: subjecting a fatty acid chloride and an amino acid to an amidation reaction under a basic condition, characterized in that, the amidation reaction uses water as a solvent, an acidic amino acid or a salt thereof as a main reactant and a small amount of a neutral amino acid or a salt thereof as an auxiliary reactant; while stirring, first adding the fatty acid chloride gradually into an aqueous solution of the acidic amino acid or a thereof; adding a base to adjust the pH value of the reaction solution; after a certain amount of the fatty acid chloride has been added, adding an aqueous solution of the neutral amino acid or a salt thereof, and continuing to add the fatty acid chloride gradually until the addition is finished and stirring to maintain the reaction.