Patent ID: 9617600
Date: 2017-04-11
CPC Classifications: A61K,A61P,C12Q

Claim:
1. A method for treating a human subject having B-cell lymphoma, comprising the steps of: (a) performing a nucleic acid-based detection assay to detect the expression levels of the RNA transcripts of marker genes in a sample comprising B lymphoma cells obtained from the human subject, wherein said marker genes comprise BCL6, IFITM1, CD40, RGS13, VNN2, LMO2, CD79B, CD22, BTG2, IGF1R, CD44, CTSC, EPDR1, UAP1, and PUS7; (b) determining that the human subject is responsive to an anti-CD40 antibody treatment using a K-nearest neighbors analysis based on the expression levels of the RNA transcripts of said marker genes in the B lymphoma cells from the human subject and reference samples with known classes; and (c) administering an effective amount of an anti-CD40 antibody to the human subject who has been determined to be responsive using the K-nearest neighbors analysis based on the expression levels of the RNA transcripts of said marker genes in the B lymphoma cells from the human subject and reference samples with known classes, thereby treating B-cell lymphoma in the human subject.