Patent ID: 9598371
Date: 2017-03-21
CPC Classifications: A61P,C07C,C07D

Claim:
1. A pharmaceutical composition comprising a compound or its pharmaceutically acceptable salt thereof and one or more pharmaceutically acceptable excipients, wherein the compound is selected from: 3-(3-((((R)-1-(Naphthalen-1-yl)ethyl)amino)methyl)-1,2,3,4-tetrahydronaphthalen-1-yl)benzoic acid hydrochloride, 2-Fluoro-5-(3-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)-1,2,3,4-tetrahydronaphthalen-1-yl)benzoic acid hydrochloride, 2-Methyl-5-(3-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)-1,2,3,4-tetrahydronaphthalen-1-yl)benzoic acid hydrochloride, 3-Methyl-5-(3-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)-1,2,3,4-tetrahydronaphthalen-1-yl)benzoic acid hydrochloride, 2,6-Dimethyl-3-(3-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)-1,2,3,4-tetrahydronaphthalen-1-yl)benzoic acid hydrochloride, 2-Methyl-4-((3S)-3-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)-1,2,3,4-tetrahydronaphthalen-1-yl)benzoic acid hydrochloride, 4-Methyl-3-((3S)-3-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)-1,2,3,4-tetrahydronaphthalen-1-yl)benzoic acid hydrochloride, 5-((3S)-3-((((R)-1-(4-Fluoro-3-methoxyphenyl)ethyl)amino)methyl)-1,2,3,4-tetrahydronaphthalen-1-yl)-2-methylbenzoic acid hydrochloride, 3-((3S)-3-((((R)-1-(4-Fluoro-3-methoxyphenyl)ethyl)amino)methyl)-1,2,3,4-tetrahydronaphthalen-1-yl)-2,6-dimethylbenzoic acid hydrochloride, 5-((3S)-3-((((R)-1-(4-Fluoronaphthalen-1-yl)ethyl)amino)methyl)-1,2,3,4-tetrahydronaphthalen-1-yl)-2-methylbenzoic acid hydrochloride, 2-Methyl-5-(3-(((R)-1-(naphthalen-1-yl)ethyl)amino)-1,2,3,4-tetrahydronaphthalen-1-yl)benzoic acid hydrochloride, 2-Methyl-4-(3-(((R)-1-(naphthalen-1-yl)ethyl)amino)-1,2,3,4-tetrahydronaphthalen-1-yl)benzoic acid hydrochloride, 5-((3S)-3-(2-(((R)-1-(4-Fluoronaphthalen-1-yl)ethyl)amino)ethyl)-1,2,3,4-tetrahydronaphthalen-1-yl)-2-methylbenzoic acid hydrochloride, 2-Methyl-5-((3S)-3-(2-(((R)-1-(naphthalen-1-yl)ethyl)amino)ethyl)-1,2,3,4-tetrahydronaphthalen-1-yl)benzoic acid hydrochloride, 5-((3S)-3-(3-(((R)-1-(4-fluoronaphthalen-1-yl)ethyl)amino)propyl)-1,2,3,4-tetrahydronaphthalen-1-yl)-2-methylbenzoic acid hydrochloride, 2-Methyl-5-((3R)-3-(3-(((R)-1-(naphthalen-1-yl)ethyl)amino)propyl)-1,2,3,4-tetrahydronaphthalen-1-yl)benzoic acid hydrochloride, 5-((3S)-3-(3-(((R)-1-(4-Fluoro-3-methoxyphenyl)ethyl)amino)propyl)-1,2,3,4-tetrahydronaphthalen-1-yl)-2-methylbenzoic acid hydrochloride, 2-Methyl-5-(3-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)-3,4-dihydroquinolin-1(2H)-yl)benzoic acid hydrochloride, 4-Methyl-3-(3-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)-3,4-dihydroquinolin-1(2H)-yl)benzoic acid hydrochloride, 2,6-Dimethyl-3-(3-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)-3,4-dihydroquinolin-1(2H)-yl)benzoic acid hydrochloride, 5-(3-((((R)-1-(4-Fluoronaphthalen-1-yl)ethyl)amino)methyl)-3,4-dihydroquinolin-1(2H)-yl)-2-methylbenzoic acid hydrochloride, 5-(3-((((R)-1-(4-Fluoro-3-methoxyphenyl)ethyl)amino)methyl)-3,4-dihydroquinolin-1(2H)-yl)-2-methylbenzoic acid hydrochloride, 2-Methyl-4-(3-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)-3,4-dihydroquinolin-1(2H)-yl)benzoic acid hydrochloride, 5-(6-Fluoro-3-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)-3,4-dihydroquinolin-1(2H)-yl)-2-methylbenzoic acid hydrochloride, 2-Methyl-5-(3-(2-(((R)-1-(naphthalen-1-yl)ethyl)amino)ethyl)-3,4-dihydroquinolin-1(2H)-yl)benzoic acid hydrochloride, 2-(2-methyl-5-(3-(2-(((R)-1-(naphthalen-1-yl)ethyl)amino)ethyl)-3,4-dihydroquinolin-1(2H)-yl)phenoxy)acetic acid hydrochloride, 2-Methyl-5-(3-(3-(((R)-1-(naphthalen-1-yl)ethyl)amino)propyl)-3,4-dihydroquinolin-1(2H)-yl)benzoic acid hydrochloride, 3-(3-(3-(((R)-1-(4-Fluoronaphthalen-1-yl)ethyl)amino)propyl)-3,4-dihydroquinolin-1(2H)-yl)-2-methylbenzoic acid hydrochloride, 2-(2-Methyl-5-(3-(3-(((R)-1-(naphthalen-1-yl)ethyl)amino)propyl)-3,4-dihydroquinolin-1(2H)-yl)phenoxy)acetic acid hydrochloride, 2-Methyl-3-(3-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)-1,2,3,4-tetrahydronaphthalen-1-yl)benzoic acid hydrochloride, 2,4-Dimethyl-5-(3-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)-1,2,3,4-tetrahydronaphthalen-1-yl)benzoic acid hydrochloride, 2-Fluoro-3-(3-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)-1,2,3,4-tetrahydronaphthalen-1-yl)benzoic acid hydrochloride, 4-Fluoro-3-(3-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)-1,2,3,4-tetrahydronaphthalen-1-yl)benzoic acid hydrochloride, 2,3-Dimethyl-5-(3-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)-1,2,3,4-tetrahydronaphthalen-1-yl)benzoic acid hydrochloride, 2-(3-(3-((((R)-1-(Naphthalen-1-yl)ethyl)amino)methyl)-1,2,3,4-tetrahydronaphthalen-1-yl)benzamido)acetic acid hydrochloride, 2-Fluoro-5-(3-(2-(((R)-1-(naphthalen-1-yl)ethyl)amino)ethyl)-1,2,3,4-tetrahydronaphthalen-1-yl)benzoic acid hydrochloride, 3-Methyl-5-(3-(2-(((R)-1-(naphthalen-1-yl)ethyl)amino)ethyl)-1,2,3,4-tetrahydronaphthalen-1-yl)benzoic acid hydrochloride, 2,6-Dimethyl-3-(3-(2-(((R)-1-(naphthalen-1-yl)ethyl)amino)ethyl)-1,2,3,4-tetrahydronaphthalen-1-yl)benzoic acid hydrochloride, 2-Methyl-3-(3-(2-(((R)-1-(naphthalen-1-yl)ethyl)amino)ethyl)-1,2,3,4-tetrahydronaphthalen-1-yl)benzoic acid hydrochloride, 4-Methyl-3-(3-(2-(((R)-1-(naphthalen-1-yl)ethyl)amino)ethyl)-1,2,3,4-tetrahydronaphthalen-1-yl)benzoic acid hydrochloride, 2,4-Dimethyl-5-(3-(2-(((R)-1-(naphthalen-1-yl)ethyl)amino)ethyl)-1,2,3,4-tetrahydronaphthalen-1-yl)benzoic acid hydrochloride, 2-Methyl-4-(3-(2-(((R)-1-(naphthalen-1-yl)ethyl)amino)ethyl)-1,2,3,4-tetrahydronaphthalen-1-yl)benzoic acid hydrochloride, 5-(3-(2-(((R)-1-(4-Fluoro-3-methoxyphenyl)ethyl)amino)ethyl)-1,2,3,4-tetrahydronaphthalen-1-yl)-2-methylbenzoic acid hydrochloride, 2,3-Dimethyl-5-(3-(2-(((R)-1-(naphthalen-1-yl)ethyl)amino)ethyl)-1,2,3,4-tetrahydronaphthalen-1-yl)benzoic acid hydrochloride, 3-Methyl-5-(3-(3-(((R)-1-(naphthalen-1-yl)ethyl)amino)propyl)-1,2,3,4-tetrahydronaphthalen-1-yl)benzoic acid hydrochloride, 2,6-Dimethyl-3-(3-(3-(((R)-1-(naphthalen-1-yl)ethyl)amino)propyl)-1,2,3,4-tetrahydronaphthalen-1-yl)benzoic acid hydrochloride, 2-Methyl-3-(3-(3-(((R)-1-(naphthalen-1-yl)ethyl)amino)propyl)-1,2,3,4-tetrahydronaphthalen-1-yl)benzoic acid hydrochloride, 4-Methyl-3-(3-(3-(((R)-1-(naphthalen-1-yl)ethyl)amino)propyl)-1,2,3,4-tetrahydronaphthalen-1-yl)benzoic acid hydrochloride, 2,4-Dimethyl-5-(3-(3-(((R)-1-(naphthalen-1-yl)ethyl)amino)propyl)-1,2,3,4-tetrahydronaphthalen-1-yl)benzoic acid hydrochloride, 2-Methyl-4-(3-(3-(((R)-1-(naphthalen-1-yl)ethyl)amino)propyl)-1,2,3,4-tetrahydronaphthalen-1-yl)benzoic acid hydrochloride, 5-(3-(3-(((R)-1-(4-Fluoro-3-methoxyphenyl)ethyl)amino)propyl)-1,2,3,4-tetrahydronaphthalen-1-yl)-2-methylbenzoic acid hydrochloride, and 2,3-Dimethyl-5-(3-(3-(((R)-1-(naphthalen-1-yl)ethyl)amino)propyl)-1,2,3,4-tetrahydronaphthalen-1-yl)benzoic acid hydrochloride.