Patent ID: 9700866
Date: 2017-07-11
CPC Classifications: A61K,B01J

Claim:
1. A liquid suspension comprising solid particles of an organic compound and surfactants associated therewith, said surfactants consisting of (a) block copolymer of polyoxyethylene and polyoxypropylene and (b) an amphiphilic compound conjugated with a hydrophilic polymer, wherein the block copolymer and said conjugated amphiphilic compound are provided in the liquid suspension in a weight ratio greater than 1:1, said block copolymer is HO(CH 2 CH 2 O) 80 (C 3 H 6 O) 27 (CH 2 CH 2 O) 80 H, said amphiphilic compound is 1,2-Distearoyl-sn-glycero-3-phophoethanolamine, said hydrophilic polymer is a polyethylene glycol polymer having a weight average molecular weight between 200 Da and 50,000 Da, the solid particles having a mean particle size from about 50 nm to about 1 μm, the organic compound has a solubility in water of less than 1 mg/mL, the suspension comprises approximately 0.1% to 1.0% (w/v) of the surfactants, and the organic compound is a therapeutic agent other than a biologic.