Patent ID: 9562099
Date: 2017-02-07
CPC Classifications: A61K,C07K,G01N

Claim:
1. An isolated antibody that binds to B7-H4, wherein the antibody binds to an epitope within all or a portion of the B7-H4 Ig-V and Ig-C domains (amino acids 29-250 of SEQ ID NO: 73) and binds to B7-H4 with an affinity of ≦50 nM, wherein the antibody comprises: (a)(i) HVR-H3 comprising the amino acid sequence of SEQ ID NO: 31, (ii) HVR-L3 comprising the amino acid sequence of SEQ ID NO: 34, and (iii) HVR-H2 comprising the amino acid sequence of SEQ ID NO: 30; or (b)(i) HVR-H3 comprising the amino acid sequence of SEQ ID NO: 60, (ii) HVR-L3 comprising the amino acid sequence of SEQ ID NO: 63, and (iii) HVR-H2 comprising the amino acid sequence of SEQ ID NO: 59.