Patent ID: 9744314
Date: 2017-08-29
CPC Classifications: A61K,A61M,A61P

Claim:
1. A method for producing a pharmaceutical aerosol for the delivery of an active compound to the mucosa of the nose, the osteomeatal complex or a paranasal sinus, said aerosol comprising a dispersed liquid phase and a continuous gas phase, said method comprising: (a) providing an aerosol generator adapted for emitting an aerosol at an effective flow rate of less than 5 liters/min of the gas phase; (b) providing a means for effecting a pressure pulsation of an aerosol having a frequency in the range from 10 to 90 Hz; (c) providing a liquid composition comprising said active compound, wherein a unit dose of the active compound is comprised in a volume of less than 5 ml of said liquid composition, and (d) operating said aerosol generator for nebulising said liquid composition into an aerosol at an effective flow rate of less than 5 liters/min of the gas phase and operating said means to effect a pressure pulsation of the aerosol at a frequency in the range from 10 to 90 Hz in such a way that a non-constant effective aerosol flow is achieved which includes one or more phases of absent effective aerosol flow wherein the duration of the phases of absent effective aerosol flow is in the range from 1 millisecond to 10 seconds; wherein the effective flow rate is the flow rate of the aerosol as it enters the respiratory system of the patient.