Patent ID: 9580499
Date: 2017-02-28
CPC Classifications: A61K,A61P,C07K

Claim:
1. A compound, comprising an antibody fused by two linkers to two single chain Fv (scFv) polypeptides, wherein: a) the antibody comprises two identical heavy chains (HCs) and two identical light chains (LCs), wherein each HC comprises a heavy chain variable region (HCVR) whose amino acid sequence is given in SEQ ID NO: 4, and wherein each LC comprises a light chain variable region (LVCR) whose amino acid sequence is given in SEQ ID NO: 13, b) the two scFv polypeptides are identical and each comprise an HCVR operably linked to an LCVR, wherein each HCVR has the amino acid sequence given in SEQ ID NO: 22, and wherein each LCVR has the amino acid sequence given in SEQ ID NO: 24, and c) the two linkers are identical glycine-rich linkers that each operably link the carboxy-terminus of one HC of the antibody to the amino-terminus of one of the scFv polypeptides.