Patent ID: 9637730
Date: 2017-05-02
CPC Classifications: A61K,A61P,C07K,C12N,C12Y,G01N

Claim:
1. A pharmaceutical composition, comprising an isolated polynucleotide that encodes an aminoacyl-tRNA synthetase (AARS) polypeptide fragment of 100-150 amino acids in length that comprises an amino acid sequence which is at least 95% identical to SEQ ID NO:64 or a fragment thereof which is at least 95% identical to SEQ ID NO:83, wherein the polynucleotide is selected from (a) a cDNA polynucleotide and (b) a modified mRNA polynucleotide, wherein the AARS polypeptide fragment has an extracellular signaling activity, and wherein the composition is substantially endotoxin-free.