Patent ID: 9725726
Date: 2017-08-08
CPC Classifications: C12N,C12Y

Claim:
1. A variant strain of Trichoderma reesei derived from a parental strain, the variant strain comprising a genetic alteration that causes cells of the variant strain to produce a reduced amount of functional mannose-1-phoshate guanyltransferase (Mpg1) protein compared to cells of the parental strain, wherein the genetic alteration comprises a disruption of the mpg1 gene present in the parental strain, wherein the cells of the variant strain produce, during aerobic fermentation in submerged culture, a cell broth that (i) requires a reduced amount of agitation to maintain a preselected dissolved oxygen content compared to the cells of the parental strain, and/or (ii) maintains an increased dissolved oxygen content at a preselected amount of agitation, compared to the cells of the parental strain.