Patent ID: 9574238
Date: 2017-02-21
CPC Classifications: A61P,C12Q,G16B

Claim:
1. A method of detecting the presence of a multiple myeloma 3 (MM3) or multiple myeloma 4 (MM4) subtype myeloma cell in a multiple myeloma patient, comprising: (a) detecting the gene expression level of one or more interferon-induced genes in a biological sample comprising CD138+ plasma cells obtained from the patient by isolating RNA isolated from the plasma cells and contacting the isolated RNA with a nucleic acid probe specific for each of the one or more interferon-induced genes, wherein the one or more interferon-induced genes is selected from among IF127, MX1, MX2, OAS1, OAS2, IFIT1, IFIT4, PLSCR1, and STAT1, and (b) detecting the presence of an MM3 or MM4 subtype myeloma cell if the gene expression level of the one or more interferon-induced genes is increased relative to the gene expression level in a sample of normal CD138+ plasma cells.