Patent ID: 9603797
Date: 2017-03-28
CPC Classifications: A61J,A61K,A61P

Claim:
1. A process for preparing an oral and/or buccal composition in the form of a thin film of a pharmaceutically active ingredient which has low solubility in water and gastrointestinal tract fluids and which belongs to classes II and IV of the BCS classification, according to which, successively: the active ingredient is suspended in a solvent in which it is not soluble, the suspension thus obtained is milled in a wet-process ball nano-mill until 90% of the particles of the active ingredient (D(90)) have a size of less than 1000 nm, the nanosuspension thus obtained is uniformly mixed with at least one film-forming polymer, the composition thus obtained is converted into a thin film, said composition thus prepared having particles of said active ingredient dispersed in said film-forming polymer and having a final water content of from 1% to 5% (w/w).