Patent ID: 9725497
Date: 2017-08-08
CPC Classifications: A61K,A61P,C07K

Claim:
1. An isolated bispecific FN3 domain containing molecule comprising a first fibronectin type III (FN3) domain and a second FN3 domain, wherein the first FN3 domain specifically binds epidermal growth factor receptor (EGFR) and blocks binding of epidermal growth factor (EGF) to EGFR, and the second FN3 domain specifically binds hepatocyte growth factor receptor (c-Met), and blocks binding of hepatocyte growth factor (HGF) to c-Met, wherein the first FN3 domain comprises an amino acid sequence of SEQ ID NO: 27, and the second FN3 domain comprises an amino acid sequence of SEQ ID NO: 41.