Patent ID: 9587240
Date: 2017-03-07
CPC Classifications: A61K,A61P,C12N

Claim:
1. A double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a target gene in a cell, comprising a complementary RNA strand and a sense RNA strand, wherein the sense RNA strand comprises a nucleotide sequence that is substantially identical to the corresponding part of the target gene, wherein the complementary RNA strand comprises a complementary nucleotide sequence that is complementary to an mRNA transcript formed during expression of the target gene, wherein the complementary strand specifically hybridizes with the mRNA transcript, wherein the complementary RNA strand and the sense strand each comprise a 3′-end and a 5′-end, wherein at least one end of one of the RNA strands is blunt, and wherein the dsRNA is 20 to 49 base pairs in length.