Patent ID: 9683237
Date: 2017-06-20
CPC Classifications: A61K,A61P,C12N,C12Q,G01N

Claim:
1. A bifunctional shRNA composition capable of reducing expression of three or more genes, comprising: a first bifunctional RNA molecule that reduces the expression of a first gene target; a second bifunctional RNA molecule that reduces the expression of a second gene target; and a third bifunctional RNA molecule that reduces the expression of a third gene target, wherein each of the bifunctional RNA molecules are capable of activating a cleavage-dependent and a cleavage-independent RNA-induced silencing complex for reducing the expression level of the first, second and third gene target, wherein the bifunctional shRNAs comprises at least one nucleic acid sequence defined by SEQ ID NOS: 2, 4, 40 or 41.