Patent ID: 9707303
Date: 2017-07-18
CPC Classifications: A61K,A61P,C12N

Claim:
1. A reduction stimulus-responsive gene delivery system, comprising a shielding system, a cationic polymer material and plasmid DNA, wherein: the cationic polymer material and the plasmid DNA are complexed to form binary complex particles, the shielding system comprises a disulfide bond, and the cationic material comprises a diselenide bond, the shielding system bonds to the surface of the binary complex by means of electrostatic interaction to form ternary complex particles, and the shielding system comprises a glycosaminoglycan derivative having a reduction-sensitive disulfide bond and at least one modified glucuronic acid unit, the at least one modified glucuronic acid unit comprising a moiety containing a carboxyl group linked via said reduction-sensitive disulfide bond.