Patent ID: 9738907
Date: 2017-08-22
CPC Classifications: A61K,C12N

Claim:
1. A lentiviral vector genome for producing a lentiviral vector particle, the lentiviral vector genome comprising: (i) an open reading frame (ORF) upstream of a promoter, wherein the promoter controls the expression of at least one downstream nucleotide sequence of interest (NOI), and (ii) a packaging signal; wherein the ORF is a heterologous sequence; wherein the ORF is a second NOI, or wherein the ORF encodes a reporter, a selectable marker, or a modulator; wherein the ORE is operably linked to an upstream lentiviral long terminal repeat (LTR); wherein the lentiviral vector genome is self-inactivating (SIN); and wherein nucleic acid sequences encoding functional Rev and functional Rev Response Element (RRE) are absent from the lentiviral vector genome; and wherein the lentiviral vector genome lacks a non-lentiviral 5′ LTR.