Patent ID: 9707000
Date: 2017-07-18
CPC Classifications: A61B,A61F,A61L,Y10T

Claim:
1. A nerve guide for peripheral nerve regeneration comprising: an outer biodegradable poly(ε-caprolactone) (PCL) membrane which forms an external surface of a hollow body in the form of a tube; a cross-linked hydrogel layer comprising polyvinyl alcohol (PVA) and poly(ethylene glycol) (PEG) in an IPN network comprising glial cell-derived neurotrophic factor (GDNF), wherein an external surface of the cross-linked hydrogel layer is coupled to an internal surface of the outer biodegradable PCL membrane; and a surface-functionalized nanofiber layer comprising electrospun fibers and a surface-tethered laminin coating, and wherein the surface-functionalized nanofiber layer is coupled to an internal surface of the cross-linked hydrogel layer to form an internal surface that defines a lumen of the hollow body.