Patent ID: 9555124
Date: 2017-01-31
CPC Classifications: A61K,A61P,C07K,C12N

Claim:
1. A method of treating a subject with inflammation or autoimmune disease comprising administering to the subject a therapeutically effective amount of recombinant cells, wherein each of the recombinant cells comprises a recombinant polynucleotide comprising an expression regulatory element operably linked to a nucleic acid sequence encoding a protein comprising the extracellular domain of B7-H4 or a fragment of the extracellular domain of B7-H4 , the fragment having the ability to induce a suppressive response in a T cell, wherein the protein is a transmembrane protein or a secretable B7-H4-Ig fusion protein, and wherein the recombinant cells are cells, or the progeny of cells, prepared by ex vivo transduction or transfection of the recombinant polynucleotide into the cells.