Patent ID: 9556238
Date: 2017-01-31
CPC Classifications: A61K,C07K,C12N

Claim:
1. A method for modifying a cell to express a magnetosome-like structure where previous to said modification the cell does not express a magnetosome-like structure, the method comprising: transfecting the cell with a construct comprising one or more magnetosome genes under the control of a promoter, said one or more magnetosome genes encoding at least one magnetosome transmembrane protein; and subjecting the cell to an environment containing iron; wherein the cell is selected from embryonic stem cells, islet cells, neuroblastoma cells, bone marrow stromal cells, breast cancer cells, glioblastoma cells, glioma cells, cervical cancer cells, promyelocytic leukemia cells, lung cancer cells, pituitary tumor cells, and T cell leukemia cells; wherein, previous to said modification, the cell did not express a magnetosome-like structure, and after said modification, the cell expresses a magnetosome-like structure comprising a lipid bilayer, an internal, iron containing region, and at least one of said magnetosome transmembrane protein within its lipid bilayer, wherein the at least one magnetosome transmembrane protein is an iron transport protein, and wherein said one or more magnetosome genes is MagA, wherein the isolated cell excludes a human embryonic stem cell.