Patent ID: 9687557
Date: 2017-06-27
CPC Classifications: A61K,A61P,C07H,C12N

Claim:
1. A conjugated nucleic acid molecule which has the following formula: wherein N is a nucleotide, n is an integer from 15 to 195, the underlined N refers to a nucleotide having or not a modified phosphodiester backbone, the linker L′ is selected from the group consisting of hexaethyleneglycol, tetradeoxythymidylate (T4), 1,19-bis(phospho)-8-hydraza-2-hydroxy-4-oxa-9-oxo-nonadecane and 2,19-bis(phosphor)-8-hydraza-1-hydroxy-4-oxa-9-oxo-nonadecane; m is 1 and L is a carboxamido oligoethylene glycol, C is selected from the group consisting of single or double chain fatty acids, tocopherol, folates or folic acid, cholesterol, a sugar or oligosaccharide, a peptide, and protein.