Patent ID: 9731046
Date: 2017-08-15
CPC Classifications: A61K,A61L

Claim:
1. A method for constructing a multi-compartment hydrogel comprising the steps of: (i) mixing a sulfated polysaccharide and at least one bioactive polypeptide capable of binding said sulfated polysaccharide, thereby forming a bioconjugate; (ii) mixing said bioconjugate of (i) with a material capable of forming a hydrogel, thereby forming a composite material comprising said bioconjugate; (iii) applying said composite material comprising said bioconjugate of (ii) to a scaffold and optionally adding a hydrogel inducer, thereby forming a hydrogel compartment in said scaffold; and (iv) repeating steps (i) to (iii) until the desired number of hydrogel compartments is obtained, wherein each time that step (i) is repeated, the bioconjugate formed in (i) comprises at least one different bioactive peptide and is therefore distinct from each one of the previously obtained bioconjugates, and each new hydrogel compartment formed in (iii) is in contact with at least one of the previously formed hydrogel compartments, thereby forming a multi-compartment hydrogel in said scaffold.