Patent ID: 9695410
Date: 2017-07-04
CPC Classifications: A61P,C07K,C12N

Claim:
1. An isolated complex comprising a major histocompatibility complex (MHC) class II HLA-DR4 and a glutamic acid decarboxylase (GAD) autoantigenic peptide, wherein said GAD autoantigenic peptide comprises a core amino acid sequence set forth by SEQ ID NO:14 (GAD556-565, FFRMVISNPA), wherein said GAD autoantigenic peptide is covalently attached at a C-terminus thereof to a linker peptide and wherein said autoantigenic peptide and said linker peptide are covalently inserted anywhere between amino acids 1-6 of an extracellular domain of a beta chain of said MHC class II HLA-DR4, wherein said linker peptide confers flexibility to said beta chain and enables folding of said GAD autoantigenic peptide within peptide-binding grooves within said MHC class II HLA-DR4.