Patent ID: 9599603
Date: 2017-03-21
CPC Classifications: A61K,A61P,G01N

Claim:
1. A method for promoting neurite outgrowth and neuronal migration, the method comprising the steps of: selecting a cadherin agonist that promotes neurite outgrowth when applied to at least one neuron disposed on a substrate coated with a purified cadherin molecule, wherein the cadherin agonist is determined to be a cadherin agonist by applying a potential cadherin modulating agent to the at least one neuron disposed on the substrate coated with the cadherin molecule and evaluating neurite outgrowth on the substrate; wherein an increase in neurite outgrowth of the at least one neuron as compared to a control indicates that the potential cadherin modulating agent is a cadherin agonist capable of promoting neurite outgrowth; and contacting at least one neuron with the cadherin agonist in an amount effective to promote neurite outgrowth, the cadherin agonist including a small molecule peptidomimetic of a peptide or cyclic peptide that comprises a cadherin cell adhesion recognition sequence.