Patent ID: 9670466
Date: 2017-06-06
CPC Classifications: A61K,A61P,C07K,C12N

Claim:
1. A method of prophylaxis against a disease caused by an infectious agent, the method comprising administering to a mammal a composition comprising a particulate delivery vehicle comprising a single-stranded RNA pestivirus replicon lacking essential codons or all codons for one or more structural proteins required for formation of infectious virus, and carrying a foreign gene encoding a gene product immunizing against the infectious agent or the disease-causing moiety, wherein the single-stranded RNA pestivirus replicon is encapsulated inside the particulate delivery vehicle to protect the single-stranded RNA pestivirus replicon against RNase degradation and wherein the particulate delivery vehicle is appropriate to deliver the single-stranded RNA pestivirus replicon to the cytoplasm of cells for replication and translation of the single-stranded RNA pestivirus replicon in the cytoplasm.