Patent ID: 9682148
Date: 2017-06-20
CPC Classifications: A61K

Claim:
1. An oral pharmaceutical composition comprising a testosterone derivative having a log P of at least 5, wherein the testosterone derivative is selected from testosterone undecanoate, testosterone enathate, testosterone oleate, or testosterone palmitate, wherein the testosterone derivative is present in an amount from about 0.5% to about 20% by weight based on 100% total weight of the composition, and a vehicle, wherein the vehicle comprises (a) a fat component comprising a monoglyceride and a triglyceride of long chain fatty acids wherein the amount of monoglyceride and triglyceride of long chain fatty acids in the fat component is at least about 500 mg sufficient to achieve lymphatic absorption in a mammal, wherein the long chain fatty acids in the monoglycerides are selected from fatty acid chains having from 14 to 22 carbon atoms and the long chain fatty acids in the triglycerides are selected from fatty acid chains having from 14 to 22 carbon atoms, wherein the weight ratio of triglycerides to monoglycerides is in a range from about 2.8:1 to about 1:5, and (b) a hydrophilic surfactant, wherein the hydrophilic surfactant is selected from hydrogenated castor oil ethoxylates, polysorbates or any other hydrophilic surfactant with a Hydrophile-Lipophile Balance (HLB) value of 10 or higher, and any combination thereof, wherein the weight ratio (a):(b) is from about 10:1 to about 1:1 and wherein composition exhibits an AUC(0-inf)(fasted)/AUC(0-inf)(fed)) of at least about 0.8.