Patent ID: 9731030
Date: 2017-08-15
CPC Classifications: A61K,A61P,Y02A

Claim:
1. A drug linker conjugate compound having formula I: or a pharmaceutically acceptable salt or solvate thereof, -A- is a Stretcher Unit; subscript a is 1 or 2 wherein the Stretcher Unit has a functional group that is capable of forming a bond with a functional group of a Ligand Unit; each —W— is independently a Glucuronide Unit having the structure of wherein Z is a self-immolative group that forms a first covalent bond with a Self-Immolative Spacer Unit of Y wherein the Glucuronide Unit structure is represented by wherein Su is a Sugar moiety; —O′— represents an oxygen atom of an O-glycosidic bond cleavable by a glycosidase; each R is independently hydrogen, a halogen, —CN, or NO subscript w is 1 or 2; —Y— is a Self-Immolative Spacer Unit; subscript y is 0, 1 or 2; and -D is a Drug Unit, wherein the wavy bond to the oxygen atom indicates covalent attachment of that atom to the Self-Immolative Spacer Unit when the subscript y is 1 or 2, or to a Drug unit when the subscript y is 0, and wherein the wavy bond to the nitrogen atom indicates covalent attachment of that atom to the Stretcher unit.