Patent ID: 9642906
Date: 2017-05-09
CPC Classifications: A61K,A61P,C12N

Claim:
1. A method of treating a human papillomavirus (HPV)-positive cancer in a subject, the method comprising: (1) generating or expanding a population of T cells specific for a HPV by a method comprising: (a) obtaining peripheral blood T-cells from a subject with HPV-positive cancer; and (b) stimulating the peripheral blood T-cells with antigen presenting cells in the presence of interleukin (IL)-7 and IL-15 and in the absence of IL-6 and/or IL-12, wherein the antigen presenting cells were previously exposed to one or more peptides, wherein the peptides comprise sequence that corresponds to at least 8 contiguous amino acids of the sequence of one or both of E6 and E7 of HPV; and (2) administering the generated or expanded population of T cells to a subject with HPV-positive cancer.