Patent ID: 9664690
Date: 2017-05-30
CPC Classifications: G01N

Claim:
1. A kit for in-vitro evaluating resistance to a steroid in a subject in need of steroid therapy, the kit comprising at least one of: (a) an immune cell stimulating agent, said steroid and at least one pro-inflammatory cytokine-specific antibody, said cytokine is selected from the group consisting of: interleukin 1A (IL-1A), IL-1, IL-2, IL-6, IL-12, IL-17, tumor necrosis factor alpha (TNFα), interferon gamma (INFγ), chemokine (C-C motif) ligand 2 (CCL2)/monocyte chemotactic protein 1 (MCP-1), and chemokine (C-C motif) ligand 5 (CCL5/RANTES); (b) an immune cell stimulating agent, said steroid, a GR agonist, and at least one pro-inflammatory cytokine-specific antibody, said cytokine is selected from the group consisting of: IL-1A, IL-1B, IL-2, IL-6, IL-12, IL-17, IL-22, TNFα, INFγ, CCL2 (MCP-1) and CCL5 (RANTES); and said kit further comprising instructions for use configured to evaluate resistance to a steroid in a subject.