Patent ID: 9603978
Date: 2017-03-28
CPC Classifications: A61L,B05D,B82Y,C23C,Y10T

Claim:
1. A method of making a medical device adapted for implantation into a human or animal host wherein the medical device comprises at least one contacting surface for contacting a bodily fluid or tissue, the method comprising: (a) depositing a plasma coating of less than 100 nm thickness on the at least one contacting surface using a silicon-containing monomer selected from trimethylsilane (TMS), vinyltrichlorosilane, tetraethoxysilane, vinyltriethoxysilane, hexamethyldisilazane, tetramethylsilane, vinyldimethylethoxysilane, vinyltrimethoxysilane, tetravinylsilane, vinyltriacetoxysilane, or methyltrimethoxysilane to produce a plasma surface; and (b) covalently bonding nitric oxide functional groups to the plasma surface using a plasma comprising a mixture of ammonia and oxygen.