Patent ID: 9562019
Date: 2017-02-07
CPC Classifications: A61P,C07D

Claim:
1. A method of inhibiting proliferation of a tumor cell carrying or expressing a cancer-associated epidermal growth factor receptor (EGFR) and/or Kirsten rat sarcoma viral oncogene homolog (KRAS) mutation comprising contacting the cell with a compound having the formula: wherein X is oxygen or NR R a is a double bond; b is a single bond; R R R Ar is selected from phenyl, indanyl, benzyl, benzothiazolyl, 1,4-benzodioxanyl and pyridinyl, each optionally and independently substituted with aliphaticoxy, aliphatic, cyano, nitro, perfluoroaliphatic, or halo; or a pharmaceutically acceptable salt thereof.