Patent ID: 9642901
Date: 2017-05-09
CPC Classifications: A61K,C07K,C12N,Y02A

Claim:
1. A method of generating an immune response in an individual against a malarial parasite, by administering to the individual an effective amount of a TAA/ecdCD40L (target associated antigen/extracellular domain of the CD40 ligand protein) multi-fragment composition comprising at least three different expression vectors, each expression vector comprising a transcription unit encoding a secretable fusion protein wherein the secretable fusion protein comprises: (i) one of each of three epitopes SEQ ID NOS. 1, 2 and 3, where each of said epitopes is a fragment from a different one of three distinct regional locations of the Circumsporozoite (CSP) antigenic protein of said malarial parasite, (ii) (ii) a secretory signal sequence for directing secretion of the fusion protein, and (iii) an ecdCD40L, wherein each of said three fragments is linked to the aminoterminal end of the ecdCD40 ligand to define said multi-fragment TAA/ecdCD40L fusion immunogenic composition and wherein each of the TAA/ecdCD40L induces neutralizing antibodies which block functions of the CSP protein.