Patent ID: 9583322
Date: 2017-02-28
CPC Classifications: G01N,H01J

Claim:
1. A method for determining the presence of or risk of developing preeclampsia by mass spectrometry, said method comprising: (a) subjecting a body fluid or tissue sample obtained from a patient to ionization under conditions suitable to produce one or more multiply charged kisspeptin-54-derived peptide ions detectable by mass spectrometry; (b) determining by mass spectrometry the amount of one or more multiply charged ions selected from the group of ions with a charge consisting of 4+, 5+, 6+, and 7+ from each of said one or more kisspeptin-54-derived peptides; and (c) using the amount of the determined ions to determine the amounts of the corresponding one or more kisspeptin-54-derived peptides in the sample; wherein elevated levels of one or more kisspeptin-54-derived peptides in the sample relative to normal levels indicate the presence of or risk of developing preeclampsia.