Patent ID: 9655815
Date: 2017-05-23
CPC Classifications: A61J,A61K,A61P,Y02A

Claim:
1. An article of manufacture comprising a DNA vaccine suitable for eliciting an immune response against cancer cells comprising a DNA construct operably encoding at least one survivin protein and at least one CCL 21 cytokine in a pharmaceutically acceptable carrier, wherein the DNA construct is incorporated in an attenuated Salmonella typhimurium vector that targets Peyer's patches in the gut, wherein the DNA vaccine induces a cytotoxic T-lymphocyte immune response against tumor cells when orally administered to the patient, and the attenuated Salmonella typhimurium vector comprises an aroA − , dam − Salmonella typhimurium strain packaged in a hermetically sealed, sterile container, the container having a label affixed thereto, the label bearing printed material identifying the vaccine and providing information useful to an individual administering the vaccine to a patient.