Patent ID: 9687582
Date: 2017-06-27
CPC Classifications: A61L,C08G,C08K

Claim:
1. A method for making a non-swelling medical adhesive comprising a hydrogel in a PBS solution at physiological temperature, the method comprising: (a) contacting a composition comprising a catechol-modified poly(ethylene oxide)-poly(propylene oxide) block copolymer having four linear PPO-PEO arms emanating from a tetrafunctional ethylenediamine core with a biocompatible oxidant in a PBS solution at room temperature or below, whereby the catechol-modified poly(ethylene oxide)-poly(propylene oxide) block copolymer is chemically cross-linked to form a hydrogel; (b) increasing the temperature of the resulting hydrogel in the PBS solution to physiological temperature; and (c) thermally equilibrating the hydrogel at physiological temperature, whereby the hydrogen exhibits no or negative swelling after at least one day in PBS solution at 37° C.