Patent ID: 9702884
Date: 2017-07-11
CPC Classifications: A61K,A61P,G01N

Claim:
1. A method, comprising: providing a biological sample from a subject desiring diagnosis regarding irritable bowel syndrome (IBS); detecting in the biological sample, a level of an anti-vinculin antibody, wherein detecting comprises using vinculin, SEQ ID NO:1 or a fragment thereof to detect the anti-vinculin antibody; determining a presence or likely presence of IBS if the level of the anti-vinculin antibody is higher than an established control level, or determining an absence or likely absence of IBS if the level of the anti-vinculin antibody is equal to or lower than an established control level, wherein the established control level is determined from a group of healthy subjects, a group of subjects with inflammatory bowel disease, or a group of subjects who are either healthy or have inflammatory bowel disease; and selecting a therapy for IBS if the presence or likely presence of IBS is determined.