Patent ID: 9611477
Date: 2017-04-04
CPC Classifications: A61K,A61P,C12N,C12Q,Y10T

Claim:
1. A synthetic, modified oligonucleotide of 10 to 30 nucleotides in length comprising at least one modification wherein the at least one modification is selected from: at least one modified sugar moiety; at least one modified internucleotide linkage; at least one modified nucleotide, and combinations thereof; wherein said oligonucleotide is an antisense compound which is at least 90% complementary to its target and is (i) is a single-stranded oligonucleotide of 10 to 30 nucleotides in length or (ii) is a siRNA of 19-30 nucleotides in length wherein both (i) and (ii) specifically hybridizes to a target comprising a complementary region of a natural antisense polynucleotide of a Tristetraproline (TTP) polynucleotide selected from the group consisting of SEQ ID NOS: 3, 4 or 5 and upregulates the function and/or expression of a Tristetraproline (TTP) gene in vivo or in vitro as compared to a normal control wherein, when the oligonucleotide is a siRNA, said siRNA targets a non-overlapping, complementary region of said natural antisense polynucleotide.