Patent ID: 9682940
Date: 2017-06-20
CPC Classifications: A61P,C07D

Claim:
1. A compound of formula (I) wherein R is selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, phenyl, furyl, thienyl, pyridyl, thiazolyl, benzothiazolyl and benzo[d][1,3]dioxolyl; wherein the phenyl, furyl, thienyl, pyridyl, thiazolyl, benzothiazolyl or benzo[d][1,3]dioxolyl is optionally substituted with one or more substituents independently selected from the group consisting of halogen, hydroxy, C is selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, phenyl, furyl, thienyl, pyridyl, thiazolyl, benzothiazolyl and benzo[d][1,3]dioxolyl; wherein the phenyl, furyl, thienyl, pyridyl, thiazolyl, benzothiazolyl or benzo[d][1,3]dioxolyl is optionally substituted with one or more substituents independently selected from the group consisting of halogen, hydroxy, C is selected from the group consisting of (a) wherein R 1 is selected from the group consisting of hydrogen, C 1-4 alkyl, hydroxy substituted C 1-4 alkyl, —C(O)—(C 1-4 alkyl), —(C 1-2 alkyl)-C(O)OH, —(C 1-2 alkyl)-C(O)—O—(C 1-4 alkyl), —(C 1-2 alkyl)-O—(C 1-2 alkyl)-C(O)OH, —(C 1-2 alkyl)-C(O)—NR E R F , —SO 2 -(fluorinated C 1-2 alkyl), C 3-6 cycloalkyl and benzyl; wherein the benzyl is optionally substituted with one substituent selected from the group consisting of —C(O)OH, —C(O)O—(C and wherein R and (b) wherein R 2 is selected from the group consisting of C 3-6 cycloalkyl and C 1-4 alkyl; a is an integer from 0 to 1; b is an integer from 0 to 1; c is an integer from 0 to 1; X is selected from the group consisting of CH and N; provided that when one or both of b or c is 0, then X is CH; such that is selected from the group consisting of piperazin-1,4-diyl, piperidin-1,4-diyl, pyrroldin-1,3-diyl and azetidin-1,3-diyl; R wherein phenyl or pyridyl is optionally substituted with one or more (preferably one to two) substituents independently selected from the group consisting of halogen, C wherein R L R wherein the phenyl, furanyl, thienyl, pyridyl, pyrazolyl and triazolyl is optionally substituted with one or more substituents independently selected from the group consisting of halogen, hydroxy, C or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof.