Patent ID: 9539345
Date: 2017-01-10
CPC Classifications: A61K,A61P

Claim:
1. A method to regulate the tumor diagnostic efficiency of a multivalent ligand by regulating the stoichiometric ratio between inner surface functionalities and ligand moieties for tumor targeting, wherein the multivalent ligand comprises: a single core consisting of a circular or spherical symmetric small molecular compound, or a radial-shaped macromolecule, wherein the core comprises terminal functional groups; said ligand moieties which are attached to a portion of the terminal functional groups of the core through a spacer; said inner surface functionalities comprising the terminal functional groups, modified terminal functional groups or the combination thereof; and one or more imaging agents which are attached to another portion of the terminal functional groups of the core; wherein the inner surface functionalities interact attractively with the surface of the tumor; and wherein the number of ligand moieties for tumor targeting accounts for 5-90% of the total number of inner surface functionalities and ligand moieties for tumor targeting.