Patent ID: 9555093
Date: 2017-01-31
CPC Classifications: A61K,A61P,C12N

Claim:
1. A universal H5N1 vaccine composition comprising a prophylactically effective amount of a first immunogenic agent or a nucleic acid encoding said first immunogenic agent, a prophylactically effective amount of a second immunogenic agent or a nucleic acid encoding said second immunogenic agent, a prophylactically effective amount of a third immunogenic agent or a nucleic acid encoding said third immunogenic agent, an adjuvant and a pharmaceutically acceptable carrier, wherein each of the first, second and third immunogenic agents comprises a virus selected from the group consisting of baculovirus, vaccina virus, adenovirus, and pox virus, wherein the virus presents or displays a full length hemagglutinin, wherein the first immunogenic agent comprises full length hemagglutinin of the virus strain A/Indonesia/CDC669/2006 (H5N1), wherein the second immunogenic agent comprises full length hemagglutinin of the virus strain A/Vietnam1203/2004 (H5N1), wherein the third immunogenic agent comprises full length hemagglutinin of the virus strain A/Anhui/1/2005 (H5N1), and wherein the composition induces antibody titers that neutralize heterologous H5N1 clades 4.0 and 7.0.