Patent ID: 9746480
Date: 2017-08-29
CPC Classifications: A61P,C12N,C12Q,G01N

Claim:
1. An in vitro method of detecting a population of CD11b+HLA-DR low HIF1α+myeloid-derived suppressor cells (MDSCs), comprising: a) contacting a sample isolated from a patient having cancer or suspected of having cancer, the sample comprising one or more of peripheral blood, peripheral blood leukocytes, red blood cell lysate of whole peripheral blood, lymph node tissue, lymph, spleen cells, cerebrospinal fluid, pleural effusion, or ascites and suspected of comprising an MDSC with a plurality of antibodies, the plurality comprising an antibody that recognizes cell surface CD11b, an antibody that recognizes cell surface HLA-DR, and an antibody that recognizes HIF1α, and b) detecting the population of CD11b+HLA-DR