Patent ID: 9687566
Date: 2017-06-27
CPC Classifications: A01K,A61K,C07K,G01N

Claim:
1. A transgenic mouse whose genome comprises a human nucleotide sequence that encodes at least two contiguous FcγR α-chain genes selected from a human FcγRIIA α-chain gene, a human FcγRIIB α-chain gene, a human FcγRIIC α-chain gene, a human FcγRIIIA α-chain gene, a human FcγRIIIB α-chain gene, and a combination thereof, wherein the human nucleotide sequence replaces mouse FcγR α-chain gene sequences in a mouse FcγR locus, and wherein the mouse comprises a functional FcR γ-chain gene and expresses the at least two contiguous FcγR α-chain genes.