Patent ID: 9663496
Date: 2017-05-30
CPC Classifications: A61P,C07B,C07D

Claim:
1. A process for providing a compound in substantially enantiomerically pure form, the compound having the formula wherein R G is —CH R each R w is 0 or 1; each R x is 0, 1 or 2; Q is a single bond, —CH each R y is 0, 1, 2, 3 or 4; in which the compound having trans-substitution on the fluoropiperidine ring, the process comprising providing the compound as a substantial mixture of enantiomers having trans-substitution on the fluoropiperidine ring; and subjecting the substantial mixture of diastereomers to chiral high pressure liquid chromatography using a stationary phase and a mobile phase to separate the substantially enantiomerically pure compound.