Patent ID: 9623117
Date: 2017-04-18
CPC Classifications: A61K

Claim:
1. A method for selectively targeting a bacterial toxin to a cell, comprising contacting a cell with a toxic bioactive fragment of a bacterial toxin associated with an antibody or ligand that is specific to a target protein on the cell, wherein the toxic bioactive fragment is associated with the antibody or ligand by an avidin/biotin or streptavidin/biotin linkage, wherein the antibody is selected from the group consisting of a low density lipoprotein receptor antibody, a transferrin receptor antibody, and a vesicular dopamine transport antibody, wherein the toxic bioactive fragment is the enzymatic domain of the bacterial toxin and lacks a functional receptor binding domain; whereby the toxic bioactive fragment is internalized and enters the cell upon selective binding of the antibody or ligand to the target protein.