Patent ID: 9645137
Date: 2017-05-09
CPC Classifications: C12Q,G01N

Claim:
1. A method for determining whether a substance is a specific inhibitor of a protein that is capable of eliciting a detectable phenoresponse, which comprises: a) incubating a test cell which expresses the protein and is capable of eliciting a phenoresponse linked to the presence and functional activity of the protein in the test cell with the substance; b) incubating a control cell which expresses the protein at a lower level or does not express the protein and is capable of eliciting a detectable phenoresponse linked to the presence and functional activity of the protein in the control cell to a lesser extent or not at all; c) comparing the phenoresponse of the test cell treated with the substance to the phenoresponse of the control cell treated with the substance; and d) determining that the substance is a specific inhibitor of the protein if the substance is capable of modulating the phenoresponse of the test cell to a greater extent than the control cell.