Patent ID: 9695250
Date: 2017-07-04
CPC Classifications: A61K,A61P,C07K

Claim:
1. A bispecific single chain antibody which comprises: (a) a first binding domain specifically binding to human CD3, and (b) a second binding domain specifically binding to human CEA, wherein said second binding domain comprises a variable light chain (V L ) region and a variable heavy chain (V H ) region, wherein said V L region comprises: a CDR-L1 having the amino acid sequence “TLRRGINVGAYSIY” (SEQ ID NO. 73); a CDR-L2 having the amino acid sequence “YKSDSDKQQGS” (SEQ ID NO. 72); and a CDR-L3 having the amino acid sequence “MIWHSGASAV” (SEQ ID NO. 71); and wherein said V L region comprises: a CDR-HI having the amino acid sequence “TYAMH” (SEQ ID NO. 70); a CDR-H2 having the amino acid sequence “LISNDGSNKYYADSVKG” (SEQ ID NO. 69); and a CDR-H3 having the amino acid sequence “DRGLRFYFDY” (SEQ ID NO. 66).