Patent ID: 9664606
Date: 2017-05-30
CPC Classifications: G01N

Claim:
1. A method for determining a viscoelastic modulus of a tissue sample possessing at least one of an optical scattering characteristic and an absorption characteristic with the use of laser speckle rheology (LSR), the method comprising: acquiring, from the tissue sample, using an optical detector coupled to a computer processor on a computing device and executing computational steps on a computer readable medium, data sets representing time evolution of speckle associated with the sample irradiated with light from a light source; determining, by the computing device, an optical property of said tissue sample based at least on a radial profile of flux determined from the acquired data sets; and calculating, by the computing device, a mean square displacement (MSD) value based on intensity temporal autocorrelation curve, which curve describes the time evolution of speckle based on the determined optical property and sample viscoelasticity.