Patent ID: 9677087
Date: 2017-06-13
CPC Classifications: A61K,A61P,C12N

Claim:
1. A method of making a kit that comprises a set of lentivirus vectors for altering allogeneic human cells for a human recipient, the method comprising: forming the set of lentivirus vectors wherein each of the lentivirus vectors expresses a sequence targeting a consensus conserved nucleic acid sequence, which when expressed in cells, functions as a negative modulator for nucleic acid encoding a domain having a mismatch in an HLA protein and wherein the set of lentivirus vectors comprises individual lentivirus vectors that correspond to individual HLA mismatches for a set of HLA mismatches that consist of HLA Class I mismatches and at least one HLA Class II mismatch; wherein the kit is for treatment of human cells by an appropriate subset of the set of lentivirus vectors based on determining a subset of the set of HLA mismatches between a human donor and a human recipient or between human cells and a human recipient.