Patent ID: 9650415
Date: 2017-05-16
CPC Classifications: A61K,A61P,C07K

Claim:
1. A composition for lowering a uric acid level, comprising a uric acid-lowering agent, wherein the uric acid-lowering agent comprises one or more tyrosine-comprising cyclic dipeptides selected from a first group consisting of cyclotyrosyltyrosine, cyclophenylalanyltyrosine and cycloleucyltyrosine, or salts thereof, and one or more tyrosine-comprising cyclic dipeptides selected from a second group consisting of cyclotryptophanyltyrosine, cycloseryltyrosine, cycloprolyltyrosine, cyclotyrosylglycine, cyclolysyltyrosine, cyclohistidyltyrosine, cycloalanyltyrosine, cycloglutamyltyrosine, cyclovalyltyrosine, cycloisoleucyltyrosine, cyclothreonyltyrosine, cycloaspartyltyrosine, cycloasparaginyltyrosine, cycloglutaminyltyrosine, cycloarginyltyrosine, cyclomethionyltyrosine, and cyclotyrosylcysteine, or salts thereof, and wherein a total amount of the tyrosine-comprising cyclic dipeptides from the first group in the uric acid-lowering agent is from 5% by weight to 90% by weight relative to a total amount of the uric acid-lowering agent, so that the tyrosine-comprising cyclic dipeptides from the first group are present in an effective amount for lowering the uric acid level, wherein the one or more tyrosine-comprising cyclic dipeptides from the first group comprises cyclophenylalanyltyrosine, and the one or more tyrosine-comprising cyclic dipeptides from the second group comprises cyclotyrosylglycine, and wherein a ratio of cyclophenylalanyltyrosine to cyclotyrosylglycine is from 90/10 to 30/70.