Patent ID: 9745249
Date: 2017-08-29
CPC Classifications: C07B,C07C

Claim:
1. Method for the preparation of a (β-substituted γ-amino carboxylic acid of general formula (I) comprising a one-pot conversion of a β-substituted γ-nitro dicarboxylate of general formula (II) to a β-substituted γ-nitro carboxylic acid of general formula (III) and a subsequent reduction of the γ-nitro group to an amine group, wherein R R wherein the one-pot conversion of (II) to (III) involves the treatment of (II) with 0.2 to 10 equivalents of a strong Brønsted acid using a carboxylic acid as solvent, in the presence of 1 to 15 equivalents of water, at a temperature of between 90° C. and 120° C. and a concentration of less than 1 M, and wherein the strong Brønsted acid is MsOH (methanesulfonic acid) or H