Patent ID: 9717715
Date: 2017-08-01
CPC Classifications: A61K,C07K,C12N

Claim:
1. A method for treatment of a cancer, comprising co-administering (a) an anti-c-Met antibody or an antigen-binding fragment thereof, and (b) at least one of lapatinib, regorafenib, vemurafenib or a combination thereof, to a subject in need of treatment of the cancer; wherein the cancer is associated with c-Met activity or overexpression of c-Met; and wherein the anti-c-Met antibody or antigen-binding fragment thereof comprises: a heavy chain variable region comprising (a) a complementarity determining region-H1 (CDR-H1) having an amino acid sequence consisting of SEQ ID NO: 1, (b) a CDR-H2 having an amino acid sequence consisting of SEQ ID NO: 2, and (c) a CDR-H3 having an amino acid sequence consisting of SEQ ID NO: 3; and a light chain variable region comprising: (a) a CDR-L1 having an amino acid sequence consisting of SEQ ID NO: 10 or 71, (b) a CDR-L2 having an amino acid sequence consisting of SEQ ID NO: 11, and (c) a CDR-L3 having an amino acid sequence comprising SEQ ID NO: 13, 14, 15, or 16.