Patent ID: 9713590
Date: 2017-07-25
CPC Classifications: A61K,A61P

Claim:
1. A method for treating acute musculoskeletal or connective tissue pain or inflammation comprising one or more of osteoarthritis, articular inflammation, periarticular inflammation, non-articular rheumatism, capsulitis, tendonitis, fibrositis, and periarticular inflammation condition, the method comprising administering a topical pharmaceutical nanogel composition of diclofenac or a salt thereof, the nanogel composition consisting of a nanoemulsion and a gel base, wherein the nanoemulsion consists of nano size droplets of diclofenac or a salt thereof having a particle size (D 90 ) of about 100 nm or less, 5% to 30% w/w oils/lipids, 0.1% to 10% w/w of emulsifiers selected from the group consisting of ionic polysorbate surfactant, nonylphenol polyethylene glycol ethers, (alkylphenol-hydroxypolyoxyethylene), poly(oxy-1,2-ethanediyl), alpha-(4-nonylphenol)-omega-hydroxy-, branched, nonylphenol polyethylene glycol ether mixtures, phenoxypolyethoxyethanols and polymers thereof, brij, and sodium dodecyl sulfate, and one or more pharmaceutically acceptable excipients consisting of initiators, pH adjusting agents, thickening agents, emollients, humectants, preservatives, and chelating agents.