Patent ID: 9566437
Date: 2017-02-14
CPC Classifications: A61N

Claim:
1. An active implantable medical device for the treatment of heart failure with vagus nerve stimulation (VNS), synchronous with cardiac activity, including: a circuit configured to analyze the cardiac rhythm by collecting an intracardiac electrogram EGM signal and detecting a ventricular depolarization R-wave in each cardiac cycle; a generator, adapted to produce discharges, each discharge comprising N pulses of VNS stimulation generable in succession, with N≧0, the generator configured to initiate the production of each possible discharge VNS with an R-wave synchronization of the moment of delivery of the first VNS pulse of this discharge; and a lead coupled to the generator, wherein the lead is used by the generator to deliver each discharge and perform sensing, wherein the generator comprises a stochastic modulation module configured to separately controlling the delivery of each of the N possible VNS pulses of each discharge according to the result of a randomization; wherein the circuit for analyzing the cardiac rhythm is further configured to evaluate a spontaneous heart rate variability parameter (VSS) and wherein the stochastic modulation is activated in response to the spontaneous heart rate variability parameter falling below a threshold.