Patent ID: 9683215
Date: 2017-06-20
CPC Classifications: A61K,A61P,C12N

Claim:
1. A method for reprogramming a first differentiated cell of exocrine origin to a second differentiated cell that exhibits at least two characteristics of a pancreatic β-cell, does not express pancreatic hormones other than insulin and does not express amylase, the method comprising increasing protein expression of transcription factors Pdx-1, Ngn3 and MaFA in the first differentiated cell of exocrine origin, thereby reprogramming the first differentiated cell of exocrine origin to a second differentiated cell that exhibits at least two characteristics of a pancreatic β-cell, does not express pancreatic hormones other than insulin and does not express amylase, wherein the first differentiated cell of exocrine origin is isolated from a subject or located in vivo within the subject.