Patent ID: 9701988
Date: 2017-07-11
CPC Classifications: C07K,C12N,C12P,C12Y,Y02E

Claim:
1. A recombinant yeast cell comprising a genetic modification that increases activity of at least one of GCR1 and GCR2, in comparison with a yeast cell of the same type that does not comprise the genetic modification that increases activity of at least one of GCR1 and GCR2, wherein the genetic modification comprises at least one of an exogenous polynucleotide encoding glycolytic genes transcriptional activator GCR1 (GCR1) and an exogenous polynucleotide encoding glycolytic genes transcriptional activator GCR2 (GCR2); wherein the recombinant yeast cell further comprises an exogenous polynucleotide encoding an enzyme converting pyruvate to lactate; wherein the yeast cell is a and wherein a gene encoding a pyruvate decarboxylase is deleted or disrupted in the recombinant yeast cell.