Patent ID: 9561304
Date: 2017-02-07
CPC Classifications: A61L,A61P

Claim:
1. A method for manufacturing a biomaterial, the method comprising: (i) mixing a biphasic calcium phosphate (BCP) comprising hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP) in an HA/β-TCP weight/weight ratio of between 5/95 and 95/5, in the form of granules whose size is between 40 and 500 μm, with blood or with a bone marrow aspirate, in a proportion ranging from 10 to 90 g by weight of BCP per 100 mL of blood or bone marrow aspirate to give a mixture; (ii) adding to the mixture of (i) at least one coagulating agent in a sufficient quantity to cause coagulation of blood or of the bone marrow aspirate, wherein the concentration of the coagulating agent is from 1 mM to 50 mM; and (iii) mixing under conditions promoting homogenization of the BCP while the coagulation occurs, and wherein the biomaterial is in the form of a malleable homogeneous paste.