Patent ID: 9657041
Date: 2017-05-23
CPC Classifications: C07B,C07C,C07F

Claim:
1. A process for the synthesis of a chiral aryl or aryl-alkyl phosphoramidate dexamphetamine precursor comprising the steps: reacting an S-[diaryl- or dialkyl-]-(2-methylaziridin-1-yl)phosphonate compound with phenylmagnesium halide in tetrahydrofuran and a copper catalyst under temperature conditions that range from 25° C. to 80° C. to obtain a chiral aryl or aryl-alkyl phosphoramidate dexamphetamine precursor; and, performing a solvent crystallization of the chiral aryl or aryl-alkyl phosphoramidate dexamphetamine precursor requiring a mixture of two or more solvents, wherein one of the solvents is residual THF, wherein the chiral aryl or aryl-alkyl phosphoramidate dexamphetamine precursor has a regioisomeric purity >99%; wherein the copper catalyst is CuCl, CuCl 2 , CuBr CuF, Cu(OAc) 2 , Cu(acac) 2 , Cu(OMe) 2 , Copper turnings or Copper nanoparticles.