Patent ID: 9644014
Date: 2017-05-09
CPC Classifications: A61K,A61P,C07K,C12N

Claim:
1. A method of treating a feline with anemia comprising administering to the feline a therapeutically-effective amount of a feline erythropoietin (fEPO) polypeptide comprising a non-naturally encoded amino acid, wherein the non-naturally encoded amino acid is substituted at a position selected from the group consisting of residues 49, 53, 76, 131, 132, and 133 of SEQ ID NO: 2, wherein the non-naturally encoded amino acid is selected from the group consisting of p-acetylphenylalanine, p-propargyl-tyrosine, m-acetylphenylalanine, O-propargyl-tyrosine, O-methyl-L-tyrosine, 3-methyl-phenylalanine, O-4-allyl-L-tyrosine, 4-propyl-L-tyrosine, L-Dopa, a fluorinated phenylalanine, isopropyl-L-phenylalanine, p-azido-L-phenylalanine, p-acyl-L-phenylalanine, p-benzoyl-L-phenylalanine, phosphonotyrosine, p-iodo-phenylalanine, p-bromophenylalanine, p-amino-L-phenylalanine, and an isopropyl-L-phenylalanine.