Patent ID: 9593140
Date: 2017-03-14
CPC Classifications: A61P,C07H

Claim:
1. A compound represented by the formula (I): or a pharmaceutically acceptable salt, ester, prodrug or solvate thereof; wherein, A is selected from the group consisting of: (1) —CHO or a protected aldehyde; (2) CH a. hydroxy or protected hydroxy; b. halogen; and c. —N (3) —CN; (4) —CH═N—NR7R8, wherein R7 and R8 are each independently selected from hydrogen, C1-C6-alkyl, optionally substituted with one or more substituents selected from the group consisting of halogen, aryl, substituted aryl, heterocyclic and substituted heterocyclic, C2-C6-alkenyl, optionally substituted with one or more substituents selected from the group consisting of halogen, aryl, substituted aryl, heterocyclic and substituted heterocyclic, C2-C6-alkynyl, optionally substituted with one or more substituents selected from the group consisting of halogen, aryl, substituted aryl, heterocyclic and substituted heterocyclic or R7 and R8 taken with the nitrogen atom to which they are connected form a 3- to 7-membered ring which may optionally contain a hetero function selected from the group consisting of —O—, —NH—, —N(C1-C6-alkyl)-, —N(aryl)-, —N(heteroaryl)-, —S—, —S(O)— and —S(O) (5) —CH═N—OR7, wherein R7 is as previously defined; (6) C3-C14-cycloalkyl; (7) substituted C3-C14-cycloalkyl; (8) aryl; (9) substituted aryl; (10) heterocyclic; (11) substituted heterocyclic; and (12) CH R1 and R2 R3 is selected from the group consisting of: (1) hydrogen; (2) a hydroxy protecting group; (3) —C(O)—C1-C12-alkyl, optionally substituted with one or more substituents selected from the group consisting of halogen, aryl, substituted aryl, heterocyclic, substituted heterocyclic, —O—R7 and —NR7R8 where R7 and R8 are as previously defined; (4) C1-C6-alkyl, optionally substituted with one or more substituents selected from the group consisting of halogen, aryl, substituted aryl, heterocyclic, substituted heterocyclic, —O—R7 and —NR7R8 where R7 and R8 are as previously defined; (5) C2-C6-alkenyl, optionally substituted with one or more substituents selected from the group consisting of halogen, aryl, substituted aryl, heterocyclic, substituted heterocyclic, —O—R7 and —NR7R8 where R7 and R8 are as previously defined; and (6) C2-C6-alkynyl, optionally substituted with one or more substitutents selected from the group consisting of halogen, aryl, substituted aryl, heterocyclic, substituted heterocyclic, —O—R7 and —NR7R8 where R7 and R8 are as previously defined; R4 is -M-Y, where M is: (1) absent, (2) —C(O)—, (3) —C(O)N(R7)-, where R7 is as previously defined, (4) —C1-C6-alkyl-N(R7)-, where R7 is as previously defined, (5) —C2-C6-allcenyl-N(R7)-, where R7 is as previously defined, or (6) —C2-C6-alkynyl-N(R7)-, where R7 is as previously defined; and where Y is: (1) hydrogen, (2) hydroxy protecting group, (3) C1-C6-alkyl, optionally substituted with one or more substituents selected from the group consisting of halogen, aryl, substituted aryl, heterocyclic and substituted heterocyclic, —OR7 where R7 is as previously defined, (4) C2-C6-alkenyl, optionally substituted with one or more substituents selected from the group consisting of halogen, aryl, substituted aryl, heterocyclic and substituted hetreocyclic, —OR7 where R7 is as previously defined, (5) C2-C6-alkynyl, optionally substituted with one or more substituents selected from the group consisting of halogen, aryl, substituted aryl, heterocyclic and substituted heterocyclic, —OR7 where R7 is as previously defined, (6) aryl, (7) substituted aryl, (8) heterocyclic, or (9) substituted heterocyclic; R5 is selected from the group consisting of: (1) hydrogen; (2) hydroxy; (3) protected hydroxy; (4) halogen; (5) —O—R7, where R7 is as previously defined; (6) —N R and each R′ is independently [1,4]-epi-[1,2,3]-triazolo R; and where each R is independently selected from the group consisting of: (1) C1-C9-alkyl, optionally substituted with one or more substituents selected from the group consisting of halogen, aryl, substituted aryl, heterocyclic and substituted heterocyclic, —OR7 where R7 is as previously defined; (2) C2-C9-alkenyl, optionally substituted with one or more substituents selected from the group consisting of halogen, aryl, substituted aryl, heterocyclic and substituted heterocyclic, —OR7 where R7 is as previously defined; (3) C2-C9-alkynyl, optionally substituted with one or more substituents selected from the group consisting of halogen, aryl, substituted aryl, heterocyclic and substituted heterocyclic, —OR7 where R7 is as previously defined; (4) C3-C14-cycloalkyl; (5) substituted C3-C14-cycloalkyl; (6) aryl; (7) substituted aryl; (8) heterocyclic; (9) substituted heterocyclic; and (10) —COOR7, where R7 is as previously defined; provided that at least one of A and R5 is a group containing R′.