Patent ID: 9555015
Date: 2017-01-31
CPC Classifications: A61K,A61P

Claim:
1. A pharmaceutical or veterinary ear wash or ear lavage composition consisting essentially of: (i) a chelating agent, wherein the chelating agent is a salt of ethylene diamine tetraacetic acid (EDTA); (ii) a buffering agent to provide a pH in the range of 6-8; and (iii) at least one polymeric biguanide or mixture thereof of formula (IV): or a pharmaceutically acceptable salt or tautomer thereof, wherein n is an integer from 3 to 500 and X wherein the at least one polymeric biguanide or mixture thereof is present in an amount ranging from 1.0 g/L to 10.0 g/L of the composition; and wherein the composition, when applied to the external ear of a mammal, achieves a reduction in the number of viable bacteria in the ear canal in a time period of from 15 to 30 seconds following exposure to the composition, and an increase in antibiotic sensitivity of bacteria in the external ear.