Patent ID: 9533989
Date: 2017-01-03
CPC Classifications: A61P,C07D

Claim:
1. A compound selected from the group consisting of: 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-({1-[3-(4-hydroxyphenyl)propyl]-1H-indol-4-yl}amino)pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-({1-[3-(3-hydroxyphenyl)propyl]-1H-indol-4-yl}amino)pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-[(4′-hydroxybiphenyl-3-yl)amino]pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-[(3′-hydroxybiphenyl-3-yl)amino]pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-{[1-(4-methylbenzyl)-1H-indol-4-yl]amino}pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-({1-[3-(3-methoxyphenyl)propyl]-1H-indol-4-yl}amino)pyrimidine-5-carboxamide; 2-{[(1R,2S*)-2-aminocyclohexyl]amino}-4-[(3′-hydroxybiphenyl-3-yl)amino]pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-{[1-(3-methylbenzyl)-1H-indol-4-yl]amino}pyrimidine-5-carboxamide; 2-{[(1R,2S)-2-aminocyclohexyl]amino}-4-[(1-benzyl-1H-indol-4-yl)amino]pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-[(3,5-dimethoxyphenyl)amino]-6-hydroxypyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-{[2-(pyridin-3-ylcarbonyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]amino}pyrimidine-5-carboxamide; 2-{[(1R,2S)-2-aminocyclohexyl]amino}-4-[(4′-hydroxybiphenyl-3-yl)amino]pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-({1-[2-(4-hydroxyphenyl)ethyl]-1H-indol-4-yl}amino)pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-{[2-(cyclobutylcarbonyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]amino}pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-{[2-(phenylacetyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]amino}pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-[(3′-methylbiphenyl-3-yl)amino]pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-({1-[3-(4-methoxyphenyl)propyl]-1H-indol-4-yl}amino)pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-[(2-propionyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-({1-[2-(4-methoxyphenyl)ethyl]-1H-indol-4-yl}amino)pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-{[1-(4-chlorobenzyl)-1H-indol-4-yl]amino}pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-({1-[2-(3-hydroxyphenyl)ethyl]-1H-indol-4-yl}amino)pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-({1-[3-(2-methoxyphenyl)propyl]-1H-indol-4-yl}amino)pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-[(2-isonicotinoyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-({1-[2-(2-hydroxyphenyl)ethyl]-1H-indol-4-yl}amino)pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-{[2-(4-hydroxybenzoyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]amino}pyrimidine-5-carboxamide; 2-{[(1R,2S)-2-aminocyclohexyl]amino}-4-{[1-(4-hydroxybenzyl)-1H-indol-4-yl]amino}pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-[(1-benzyl-1H-indol-5-yl)amino]pyrimidine-5-carboxamide; 2-{[(1R,2S)-2-aminocyclohexyl]amino}-4-({1-[2-(4-hydroxyphenyl)ethyl]-1H-indol-4-yl}amino)pyrimidine-5-carboxamide; 2-{[(1R,2S)-2-aminocyclohexyl]amino}-4-({1-[3-(4-hydroxyphenyl)propyl]-1H-indol-4-yl}amino)pyrimidine-5-carboxamide; 2-{[(1R,2S)-2-aminocyclohexyl]amino}-4-{[1-(3-hydroxybenzyl)-1H-indol-4-yl]amino}pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-{[1-(3-phenylpropyl)-1H-indol-4-yl]amino}pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-({1-[2-(3-methoxyphenyl)ethyl]-1H-indol-4-yl}amino)pyrimidine-5-carboxamide; 2-{[(1R,2S)-2-aminocyclohexyl]amino}-4-({1-[2-(4-methoxyphenyl)ethyl]-1H-indol-4-yl}amino)pyrimidine-5-carboxamide; methyl 7-[(2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-5-carbamoylpyrimidin-4-yl)amino]-3,4-dihydroisoquinoline-2(1H)-carboxylate; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-({1-[2-(2-methoxyphenyl)ethyl]-1H-indol-4-yl}amino)pyrimidine-5-carboxamide; ethyl 7-[(2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-5-carbamoylpyrimidin-4-yl)amino]-3,4-dihydroisoquinoline-2(1H)-carboxylate; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-{[1-(2-phenylethyl)-1H-indol-4-yl]amino}pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-{[2-(ethylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]amino}pyrimidine-5-carboxamide; 2-{[(1R,2S)-2-aminocyclohexyl]amino}-4-({1-[3-(4-methoxyphenyl)propyl]-1H-indol-4-yl}amino)pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-[(1-benzyl-1H-indol-6-yl)amino]pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-{[2-(2-hydroxybenzoyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]amino}pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-[(4′-chloro-3′-hydroxybiphenyl-3-yl)amino]pyrimidine-5-carboxamide; phenyl 7-[(2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-5-carbamoylpyrimidin-4-yl)amino]-3,4-dihydroisoquinoline-2(1H)-carboxylate; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-{[2-(3-hydroxybenzoyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]amino}pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-[(2-benzoyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-({2-[3-(methylthio)benzoyl]-1,2,3,4-tetrahydroisoquinolin-7-yl}amino)pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-{[2-(benzylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]amino}pyrimidine-5-carboxamide; isopropyl 7-[(2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-5-carbamoylpyrimidin-4-yl)amino]-3,4-dihydroisoquinoline-2(1H)-carboxylate; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-[(4′-chlorobiphenyl-3-yl)amino]pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-({1-[3-(methylthio)benzyl]-1H-indol-4-yl}amino)pyrimidine-5-carboxamide; 4-[(2-acetyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]-2-{[(1R*,2S*)-2-aminocyclohexyl]amino}pyrimidine-5-carboxamide; 2-{[(1R,2S)-2-aminocyclohexyl]amino}-4-{[1-(2-hydroxybenzyl)-1H-indol-4-yl]amino}pyrimidine-5-carboxamide; benzyl 7-[(2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-5-carbamoylpyrimidin-4-yl)amino]-3,4-dihydroisoquinoline-2(1H)-carboxylate; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-{[2-(3-fluorobenzoyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]amino}pyrimidine-5-carboxamide; cyclopropyl 7-[(2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-5-carbamoylpyrimidin-4-yl)amino]-3,4-dihydroisoquinoline-2(1H)-carboxylate; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-{[2-(methylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]amino}pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-{[1-(2-fluorobenzyl)-1H-indol-4-yl]amino}pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-{[2-(cyclopropylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]amino}pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-{[2-(4-fluorobenzoyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]amino}pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-({1-[4-(methylthio)benzyl]-1H-indol-4-yl}amino)pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-[(2-pyridin-2-yl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-{[1-(2-methylbenzyl)-1H-indol-4-yl]amino}pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-{[2-(3-methoxybenzoyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]amino}pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-{[2-(3-ethylbenzoyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]amino}pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-{[2-(cyclohexylcarbonyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]amino}pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-{[2-(isopropylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]amino}pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-{[2-(2-methoxybenzoyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]amino}pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-{[2-(4-methylbenzoyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]amino}pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-{[2-(2-chlorobenzoyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]amino}pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-{[1-(2-chlorobenzyl)-1H-indol-4-yl]amino}pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-{[2-(2-fluorobenzoyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]amino}pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-{[3-(phenoxymethyl)phenyl]amino}pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-{[2-(4-chlorobenzoyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]amino}pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-{[2-(cyclopentylcarbonyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]amino}pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-{[1-(3-chlorobenzyl)-1H-indol-4-yl]amino}pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-{[2-(3-methylbenzoyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]amino}pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-{[2-(cyclopropylcarbonyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]amino}pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-({2-[4-(methylthio)benzoyl]-1,2,3,4-tetrahydroisoquinolin-7-yl}amino)pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-{[2-(4-ethylbenzoyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]amino pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-{[1-(3-methoxybenzyl)-1H-indol-6-yl]amino}pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-{[1-(4-methoxybenzyl)-1H-indol-6-yl]amino}pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-{[3-(4-methoxybenzyl)phenyl]amino}pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-{[1-(2-methoxybenzyl)-1H-indol-6-yl]amino}pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-{[2-(2-ethylbenzoyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]amino}pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-{[2-(3-chlorobenzoyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]amino}pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-{[2-(pyridin-2-ylcarbonyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]amino}pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-{[1-(3-phenoxybenzyl)-1H-indol-4-yl]amino}pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-{[2-(4-methoxybenzoyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]amino}pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-({2-[2-(methylthio)benzoyl]-1,2,3,4-tetrahydroisoquinolin-7-yl}amino)pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-{[3-(4-chlorobenzyl)phenyl]amino}pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-{4-[1-(biphenyl-4-ylmethyl)-1H-indol-4-yl]amino}pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-[(2-benzyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-({3-[(3-hydroxyphenyl)thio]phenyl}amino)pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-({3-[(4-hydroxyphenyl)thio]phenyl}amino)pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-({3-[(4-methoxyphenyl)thio]phenyl}amino)pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-{[2-(2-methylbenzoyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]amino}pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-{[1-(4-hydroxybenzyl)-1H-indol-6-yl]amino}pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-{[3-(3-methylbenzyl)phenyl]amino}pyrimidine-5-carboxamide; 2-{[(1R,2S)-2-aminocyclohexyl]amino}-4-({3-[2-(methylamino)-2-oxoethoxy]phenyl}amino)pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-{[1-(cyclopropylcarbonyl)-1,2,3,4-tetrahydroquinolin-7-yl]amino}pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-({3-[(4-chlorophenyl)thio]phenyl}amino)pyrimidine-5-carboxamide; 2-{[(1R,2S)-2-aminocyclohexyl]amino}-4-{[1-(4-hydroxybenzyl)-1H-indol-4-yl]amino}pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-{[2-(phenylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]amino}pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-[(2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidine-5-carboxamide; 2-{[(1R*,2S*R)-2-aminocyclohexyl]amino}-4-({3-[(3-methylphenyl)thio]phenyl}amino)pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-{[1-(2-methoxybenzyl)-1H-indol-5-yl]amino}pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-({3-[(3-methoxyphenyl)thio]phenyl}amino)pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-[(3-benzylphenyl)amino]pyrimidine-5-carboxamide; 2-{[(1R,2S)-2-aminocyclohexyl]amino}-4-[(3′-hydroxybiphenyl-3-yl)amino]-6-methylpyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-{[3-(phenylthio)phenyl]amino}pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-[(4-benzylphenyl)amino]pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}tetrahydroisoquinolin-7-ylamino)pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-{[4-(phenylthio)phenyl]amino}pyrimidine-5-carboxamide; 2-{[(1R,2S)-2-aminocyclohexyl]amino}-4-[(4′-hydroxybiphenyl-3-yl)amino]-6-methylpyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-[(2-isobutyryl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-{[1-(cyclopropylcarbonyl)-1,2,3,4-tetrahydroquinolin-5-yl]amino}pyrimidine-5-carboxamide; 2-{[(1R*,2S*)-2-aminocyclohexyl]amino}-4-{[1-(2-phenoxybenzyl)-1H-indol-4-yl]amino}pyrimidine-5-carboxamide; and a pharmaceutically acceptable salt thereof.