Patent ID: 9586998
Date: 2017-03-07
CPC Classifications: C07K,C12N

Claim:
1. A method of propagating a monkey adenovirus, which method comprises contacting a cell with the monkey adenovirus, wherein the monkey adenovirus comprises a nucleic acid sequence encoding one or more gene products of a human adenovirus, wherein the one or more gene products comprise a gene product encoded by a portion of the E4 region responsible for alleviating or overcoming host replication block in human cells, which portion consists essentially of E4 ORF6, and whereby the monkey adenovirus is propagated in the cell, wherein the monkey adenovirus further comprises inverted terminal repeat (ITR) sequences from the monkey adenovirus, wherein monkey refers to both new world and old world monkeys, and does not include any member of the family Hominidae.