Patent ID: 9554992
Date: 2017-01-31
CPC Classifications: A61K,A61M,A61P

Claim:
1. Multicomponent microparticles, for use in a formulation for inhalation, each microparticle comprising a combination of beclometasone dipropionate, formoterol fumarate, and glycopyrronium bromide as active ingredients in a weight ratio of 35:15:45 to 94:1:5 w/w/w, wherein said microparticles have a shape factor of from 0.80 to 1.15, and wherein said microparticles are obtained by a process comprising: a) preparing a solution of said beclometasone dipropionate, formoterol fumarate, and glycopyrronium bromide in a pre-determined ratio in a solvent consisting of a mixture of ethanol:water in a ratio of from 85:15 to 95:5 v/v; b) generating an aerosol from said solution, to obtain atomized droplets; c) drying said atomized droplets to yield the microparticles; and d) isolating said microparticles.