Patent ID: 9714292
Date: 2017-07-25
CPC Classifications: A61K,A61P,C07K

Claim:
1. A bispecific antibody comprising a first antigen-binding site that specifically binds to human TWEAK and a second antigen-binding site that specifically binds to human IL17, wherein the bispecific antibody inhibits: a) TWEAK induced proliferation of human fibroblast-like synoviocytes-rheumatoid arthritis (HFLS-RA) with an IC50 value of 0.2 nM or lower; and b) IL17 induced IL6 cytokine stimulation of human fibroblast-like synoviocytes-rheumatoid arthritis (HFLS-RA) with an IC50 value of 3.0 nM or lower.