Patent ID: 9663556
Date: 2017-05-30
CPC Classifications: A61K,A61P,C07K,C12N

Claim:
1. A polypeptide having an amino acid sequence comprising, in the following order: (i) a transcription factor (TF) domain sequence from a human immunodeficiency virus (HIV) or a simian immunodeficiency virus (SIV) trans-activator of transcription (Tat) protein, wherein the TF domain comprises the amino acid sequence of one of SEQ ID NOs:96-123; (ii) a cysteine-rich domain sequence from SIV, HIV, or a defensin, wherein the cysteine-rich domain comprises the amino acid sequence of one of SEQ ID NOs:124-132; and (iii) a C-terminal domain sequence from a HIV or SIV Tat protein, wherein the C-terminal domain comprises the amino acid sequence of one of SEQ ID NOs:133-150; wherein the TF domain sequence, the cysteine-rich domain sequence, and the C-terminal domain sequence include sequences from at least two different species of primate, and the polypeptide is not SEQ ID NO:2, 3, or 4.