Patent ID: 9598710
Date: 2017-03-21
CPC Classifications: A61K,A61P,A61Q,C12N,C12P,C12Y,Y02E,Y02P

Claim:
1. An isolated genetically modified non-mammalian organism, wherein the activity of both ARE1 and ARE2 of acyl-CoA:sterol acyltransferase/sterol O-acyltransferase (EC 2.3.1.26) and/or activity of diacylglycerol acyltransferase/diacylglycerol O-acyltranferase (EC 2.3.1.20) and/or activity of lecithin cholesterol acyl transferase/phospholipid: diacylglycerol acyltransferase (EC 2.3.1.158) are reduced or abolished in comparison with a corresponding wildtype organism, and wherein the activity of 3-hydroxy-3-methyl-glutaryl-Coenzyme-A-reductacse (HMG-CoA-reductase) (EC1.1.1.34), is increased in comparison with the corresponding wildtype organism.