Patent ID: 9540424
Date: 2017-01-10
CPC Classifications: A61K,A61P,C07K,C12N,C12P

Claim:
1. A nucleic acid encoding a polypeptide comprising a fibronectin type III tenth ( 10 Fn3) domain, wherein the 10 Fn3 domain binds to domain 1 or 2 of human serum albumin with a K D of 1 μM or less, and wherein the 10 Fn3 domain comprises a modified amino acid sequence in one or more of the BC, DE and FG loops relative to the wild-type human 10 Fn3 domain (SEQ ID NO: 1), and wherein the polypeptide comprises an amino acid sequence at least 75% identical to an amino acid sequence selected from SEQ ID NOs: 4, 8, 12, 16, 20, and 24-44.