Patent ID: 9695191
Date: 2017-07-04
CPC Classifications: A61K,A61P,C07D

Claim:
1. Compounds of the general formula I incorporating the building blocks A, B and C wherein the encircled moiteties a, b and c in building blocks A, B and C are selected from Tables 1, 2 and 3, respectively, and are appropriately and independently substituted as defined below: the encircled parts of the bridge subunits c1-c3 representing optionally substitued groups, definitions of c1-c3 being depicted in Table 3, below, each reading from the N-terminus to the C-terminus of the linker C, said linker C being, in the simplest case, constituted by one subunit c1, i.e. c1-1 to c1-6, and for the embodiments consisting of two or three subunits all possible combinations of the subunits c1-c3 and the connectivities U, V and W being possible; the substituents directly attached to building blocks A, B and C, i.e. R 1 -R 17 , being defined as follows: R —(CR —(CR —(CR —(CR —(CR —(CR —(CR R —(CR —(CR —(CR —(CR —(CR —(CR R R R —(CR —(CR —(CR —(CR —(CR —(CR —(CR R R —(CR —(CR —(CR —(CR —(CR R R —(CR —(CR —(CR —(CR R substituents introduced in the sub-definitions of the radical R 1 -R 17 being defined as follows: R —(CR —(CR —(CR —(CR —(CR —(CR —(CR R R —(CR —(CR —(CR —(CR —(CR —(CR R R —(CR —(CR —(CR —(CR —(CR —(CR R R R R R —(CR R —(CR —(CR —(CR R —(CR —(CR —(CR —(CR —(CR —(CR R R R R —(CR —(CR —(CR —(CR —(CR —(CR R R —(CR —(CR —(CR —(CR —(CR R —(CR —(CR —(CR R —(CR R —(CR R —NR —NR R —(CR R R —NR R R —(CR —(CR R —(CR —(CR taken together the following pairs of said substituents can define cyclic structural elements: (R in addition, the structural elements —NR varibale heteroatoms and connector groups in the aforementioned structures being as follows: Z: O; S; S(═O); S(═O) Y: O; S; or NR X: O; S; S(═O); or S(═O) Q: O; S; or NR U, V and W: as defined in Table 3, above; T: CR in case T occurs several times in the same ring structure each T being defined independently of the other; and the indices being defined as follows: all possible stereoismers and pharmaceutical acceptable salts thereof.