Patent ID: 9701725
Date: 2017-07-11
CPC Classifications: A61K,A61P,C07K,C12N

Claim:
1. A nucleic acid molecule encoding a fusion polypeptide useful as a vaccine composition, which molecule comprises: (a) a first nucleic acid sequence encoding a first polypeptide or peptide that promotes processing via the MHC class I pathway, wherein the first polypeptide or peptide is encoded by (b) fused in frame with the first nucleic acid sequence, a second nucleic acid sequence encoding a signal peptide for secreting the fusion polypeptide; and (c) a third nucleic acid sequence that is linked in frame to said first nucleic acid sequence and that encodes a non-oncogenic mutant of an E7 polypeptide of HPV-16 having the sequence SEQ ID NO: 2, said mutant of SEQ ID NO: 2 comprises a Glycine at positions 24 and 26, wherein positions 24 and 26 correspond to positions 24 and 26 of SEQ ID NO: 2.