Patent ID: 9550760
Date: 2017-01-24
CPC Classifications: A61K,A61P,C07D

Claim:
1. A compound of the formula (I) or its pharmaceutically acceptable salts, hydrates, solvates, and individual diastereomers thereof, wherein; R is selected from: (i) hydrogen, amino, alkyl amino; (ii) C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl; (iii) K—Ar; Ar represents heteroaryl or aryl, each of which is substituted with from 0 to 4 substituents independently chosen from: (1) halogen, hydroxy, amino, amide, cyano, —COOH, —SO2NH2, oxo, nitro and alkoxycarbonyl; and (2) C1-C6 alkyl, C1-C6 alkoxy, C3-C10 cycloalkyl, C2-C6 alkenyl, C2-C6 alkynyl, C2-C6 alkanoyl, C1-C6 haloalkyl, C1-C6 haloalkoxy, mono- and di-(C1-C6 alkyl)amino, C1-C6 alkylsulfonyl, mono- and di-(C1-C6alkyl) sulfonamido and mono- and di-(C1-C6 alkyl)aminocarbonyl; phenyl C0-C4 alkyl and (4- to 7-membered heterocycle) C0-C4 alkyl, each of which is substituted with from 0 to 4 secondary substituents independently chosen from halogen, hydroxy, cyano, oxo, imino, C1-C4 alkyl, C1-C4 alkoxy and C1-C4 haloalkyl; K is selected from a) O, S, SO, SO2; b) (CH2)m, m=0-3, —O(CH2)p, p=1-3, —S(CH2)p, p=1-3,—N(CH2)p, p=1-3, —(CH2)pO, p=1-3; c) NR1 R1 represents hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl, alkylthio, aryl, arylalkyl; (iv) groups of the formula (Ia); (Ia) wherein: R2 represents hydrogen, C1-C4 alkyl, oxo; X is CH, when R3 is hydrogen; or X—R3 is O; or X is N, R3 represents groups of hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C10 aryl or heteroaryl, (C3-C7cycloalkyl)C1-C4alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 alkylthio, C2-C6 alkanoyl, C1-C6 alkoxycarbonyl, C2-C6 alkanoyloxy, mono- and di-(C3-C8 cycloalkyl)aminoC0-C4alkyl, (4- to 7-membered heterocycle)C0-C4alkyl, C1-C6 alkylsulfonyl, mono- and di-(C1-C6 alkyl) sulfonamido, and mono- and di-(C1-C6alkyl)aminocarbonyl, each of which is substituted with from 0 to 4 substituents independently chosen from halogen, hydroxy, cyano, amino, —COOH and oxo; Het is selected from any heterocycle, which is substituted with from 0 to 4 substituents independently chosen from: (i) C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl; (ii) halogen, hydroxy, amino, amide, cyano, —COOH, —SO2NH2, oxo, nitro and alkoxycarbonyl, (iii) aryl; R11 and R12 are independently selected from: Hydrogen, F, Cl, Br, CN, C1-C4 alkyl, C1-C6 alkoxy; R13, R14 and R15 are independently selected from Hydrogene, C1-C4 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C10 aryl or heteroaryl, C1-C6 alkoxy, C1-C6 alkylthio, C2-C6 alkanoyl, C1-C6 alkoxycarbonyl, C2-C6 alkanoyloxy.