Patent ID: 9629941
Date: 2017-04-25
CPC Classifications: A61L

Claim:
1. A titanium dioxide scaffold comprising an open porous structure, wherein at least part of the surface of said titanium dioxide scaffold is provided with a hydrogel coating comprising at least one biologically active substance, wherein a portion of said coating is formed on the walls of pores inside the scaffold, and wherein said coating does not substantially block the pores, wherein said titanium dioxide scaffold is produced by a method comprising the steps of: a) providing a titanium dioxide scaffold; b) providing a polymer solution comprising a biologically active substance and about 1-10% w/v of a polymer having a molecular weight (Mw) of 1,000-1,000,000 g/mol, to at least part of said titanium dioxide scaffold and then centrifuging the titanium dioxide scaffold; and c) effecting gelation of the polymer provided to the titanium dioxide scaffold in step (b).