Patent ID: 9649496
Date: 2017-05-16
CPC Classifications: A61B,A61N

Claim:
1. A method of operating a medical device system, the method comprising: determining changes in device-based therapy provided to a subject using a therapy output circuit of the medical device system, wherein the therapy output circuit is coupleable to a therapy delivery electrode; identifying that the changes in device-based therapy include changes to a maximum interval of cardiac electrostimulation provided according to the device-based therapy; identifying increases and decreases in a diastolic filling interval of the subject resulting from the changes in maximum interval of cardiac electrostimulation; determining an indication of physiologic response of the subject to the increases and decreases in the diastolic filling interval, including determining a disproportionate change in a diastolic interval compared to a change in a corresponding systolic interval resulting from the changes in maximum interval of cardiac electrostimulation; and adjusting a therapy control circuit according to the determined indication of physiologic response.