Patent ID: 9725518
Date: 2017-08-08
CPC Classifications: A61K,A61N,A61P,C07K

Claim:
1. An antibody which specifically recognises an epitope comprising a portion of the Delta/Serrate/LAG-2 sequence (DSL) domain of human Jagged 1 and blocks the interaction between human Jagged 1 and any receptor selected from the group consisting of Notch and CD46; wherein said portion of the DSL domain of human Jagged 1 comprises the residue E228, and wherein said antibody comprises a CDR-L1, CDR-L2 and CDR-L3 having the amino acid sequence of SEQ ID NO: 1, 27 and 3 respectively; and a CDR-H1, CDR-H2 and CDR-H3 having the amino acid sequence of SEQ ID NO: 4, 5 and 6 respectively.