Patent ID: 9587242
Date: 2017-03-07
CPC Classifications: C12N

Claim:
1. A variant strain of filamentous fungus derived from a parental strain selected from the group consisting of a Trichoderma reesei, Aspergillus niger, Aspergillus itaconicus, Aspergillus oryzae, Aspergillus terreus, Aspergillus sojae, Aspergillus japonicus, Neurospora crassa, Penicillium funiculosum, Penicillium chrysogenum, Talaromyces ( Geosmithia ) emersonii, Fusarium venenatum and Chrysosporium lucknowense , the variant strain comprising a genetic alteration that causes cells of the variant strain to produce a reduced amount of functional beta-1,3-glucanosyltransferase (Gas1) protein and a reduced amount of functional sfb3 protein compared to cells of the parental strain, wherein the cells of the variant strain produce during aerobic fermentation in submerged culture a cell broth that (i) requires a reduced amount of agitation to maintain a preselected dissolved oxygen content compared to the cells of the parental strain, and/or (ii) maintains an increased dissolved oxygen content at a preselected amount of agitation, compared to the cells of the parental strain.