Patent ID: 9700025
Date: 2017-07-11
CPC Classifications: A01K,A61K,C07H,C07K,C12N

Claim:
1. A mouse comprising (a) at a first endogenous major histocompatibility complex (MHC) II gene locus a first and second nucleotide sequence, each respectively encoding a first chimeric human/mouse MHC II α polypeptide and a first chimeric human/mouse MHC II β polypeptide, and each respectively expressed under regulatory control of endogenous MHC II α and β promoters at the first endogenous MHC II gene locus, (b) at a second endogenous MHC II locus a third and fourth nucleotide sequence, each respectively encoding a second chimeric human/mouse MHC II α polypeptide and a second chimeric human/mouse MHC II β polypeptide, and each respectively expressed under regulatory control of endogenous MHC II α and β promoters at the second endogenous MHC II gene locus, wherein the mouse expresses the first chimeric human/mouse MHC II α and β polypeptides as a first chimeric human/mouse MHC II complex and the second chimeric human/mouse MHC II α and β polypeptides as a second chimeric human/mouse MHC II complex on the surface of an antigen presenting cell.