Patent ID: 9644196
Date: 2017-05-09
CPC Classifications: A61K,A61P,C07K,C12N,C12Q,C12Y

Claim:
1. A proteolytically active or reversibly inactivated plasmin variant comprising a plasmin heavy chain and a plasmin light chain, wherein the carboxyl terminus of the plasmin heavy chain amino acid sequence comprises the tripeptide sequence Pro-Gly-Arg of amino acids 559-561 of SEQ ID NO:1 and wherein the plasmin light chain comprises the amino acids 562-791 of SEQ ID NO:1, with the exception that the light chain has: (a) an amino acid other than valine at position 562 of SEQ ID NO:1; (b) an amino acid other than valine at position 563 of SEQ ID NO:1; (c) an amino acid other than glycine at position 564 of SEQ ID NO:1; (d) an amino acid other than glycine at position 565 of SEQ ID NO:1; (e) two or more of (i) an amino acid other than valine at position 562 of SEQ ID NO:1; (ii) an amino acid other than valine at position 563 of SEQ ID NO:1; (iii) an amino acid other than glycine at position 564 of SEQ ID NO:1; and (iv) an amino acid other than glycine at position 565 of SEQ ID NO:1; or (f) an amino acid other than valine at position 562 of SEQ ID NO:1 and an amino acid other than lysine at position 708 of SEQ ID NO:1.