Patent ID: 9623150
Date: 2017-04-18
CPC Classifications: A61K,A61L,A61P,A61Q

Claim:
1. An injectable hydrogel, for providing gradual long-term release of glycerol in the skin, comprising by weight relative to total weight of the hydrogel, in a physiologically acceptable carrier fluid: 0.5% to 2.5% of glycerol, and 0.5% to 3% of a crosslinked biopolymer of hyaluronic acid or a salt thereof, wherein the hyaluronic acid or salt thereof has a molecular weight of between 5×10 wherein the hydrogel is prepared by a process comprising: preparing a mixture comprising the crosslinked biopolymer of hyaluronic acid or salt thereof; adding glycerol to the mixture before, during or after crosslinking the biopolymer so as to form a homogeneous mixture; transforming the homogenous mixture into a gel; and sterilizing the gel in moist heat at a temperature of 130-131° C. for 1-3 min.