Patent ID: 9555047
Date: 2017-01-31
CPC Classifications: A61K,A61P

Claim:
1. A method of manufacturing an injectable formulation comprising controlled- or sustained-release microparticles comprising triamcinolone acetonide (TCA) or a pharmaceutically-acceptable salt thereof and a poly(lactic-co-glycolic) acid copolymer (PLGA) matrix.; wherein the TCA comprises between 22% to 28% of the microparticle and wherein the PLGA has the following characteristics: (i) a molecular weight in the range or about 40 to 70 k Da; and (ii) a lactic acid: glycolic acid molar ratio of 80:20 to 60:40, the method comprising: (a) dispersing the TCA and the poly(laclic-co-glycolic) acid copolymer in an organic solution to produce a TCA-PLGA mixture, wherein the PLGA has a molecular weight in the range of about 40 to 70 kDa and a lactic acid: glycolic acid molar ratio of 80:20 to 60:40, and wherein the ratio of TCA to PLGA to organic solution in the TCA-PLGA mixture is 1:3:57; (b) atomizing the TCA-PLGA mixture into micro-droplets by adding the TCA-PLGA mixture to a spinning disk; and (c) treating the TCA-PLGA mixture to remove the solvent, thereby producing an injectable formulation comprising controlled- or sustained-release microparticle comprising TCA or a pharmaceutically-acceptable salt thereof and a PLGA matrix wherein the TCA comprises between 22% to 28% of the microparticles and wherein the PLGA has the following characteristics: (i) a molecular weight in the range or about 40 to 70 k Da; and (ii) a lactic acid: glycolic acid molar ratio of 80:20 to 60:40.