Patent ID: 9603803
Date: 2017-03-28
CPC Classifications: A61K,A61P

Claim:
1. A process for producing a solid pharmaceutical powder, comprising the steps of: (a) providing a feed mixture of microcrystalline cellulose (MCC) and a solution of hydroxypropylmethyl cellulose (HPMC) and 4-[[6-amino-5-bromo-2-[(4-cyanophenyl)amino]-4-pyrimidinyl]oxy]-3,5-dimethylbenzonitrile (TMC 125), or a pharmaceutically acceptable acid addition salt thereof, in a solvent; wherein the weight ratio of MCC:HPMC:TMC 125 is 0.5:3:1; and (b) spray-drying the feed mixture from step (a) by introducing the feed mixture as droplets into a spray-drying chamber via an atomizing means to form a solid dispersion of amorphous 4-[[6-amino-5-bromo-2-[(4-cyanophenyl)amino]-4-pyrimidinyl]oxy]-3,5-dimethylbenzonitrile or a pharmaceutically acceptable acid addition salt thereof, the hydroxypropylmethyl cellulose, and the microcrystalline cellulose; wherein the solid dispersion has a density of about 0.1 to 0.7 g/ml.