Patent ID: 9702878
Date: 2017-07-11
CPC Classifications: A61P,C07K,C12Q,G01N

Claim:
1. An in vitro method for diagnosing a subject with an increased risk of bone metastasis or recurrence of a triple negative (including basal-like) breast cancer in a subject suffering said cancer and treating said subject to inhibit or prevent said bone metastasis or recurrence, comprising detecting amplification and/or gain of the c-MAF gene in a sample of said subject relative to a reference gene copy number, wherein an amplification and/or gain of the c-MAF gene with respect to said reference gene copy number is indicative of increased risk of developing bone metastasis or recurrence, and administering a therapeutically effective amount of a c-MAF inhibitor, a therapy aiming to prevent and/or treat bone metastasis selected from the group consisting of an mTor inhibitor, a Src kinase inhibitor, a COX-2 inhibitor, a CCR-5 antagonist and/or Radium-223, and/or an agent capable of avoiding and/or preventing bone degradation to said subject with an increased risk of bone metastasis or recurrence.