Patent ID: 9683043
Date: 2017-06-20
CPC Classifications: A61K,A61P,C07K,G01N

Claim:
1. An isolated antibody selected from: a) a monoclonal antibody that binds PD-1 and is produced by the hybridoma clone 2 or antigen binding fragment thereof, said hybridoma clone being deposited with the European Collection of Cell Cultures (ECACC) under accession number 08090903; b) an isolated antibody that binds PD-1 or antigen binding fragment comprising SEQ ID NO: 2 and SEQ ID NO: 4 or SEQ ID NO: 8; c) a bispecific, humanized, single-chain, chimeric or recombinant antibody that binds PD-1 comprising a light chain variable region comprising SEQ ID NO: 15 (light chain CDR1), SEQ ID NO: 16 (light chain CDR2) and SEQ ID NO: 17 (light chain CDR3) and a heavy chain variable region comprising SEQ ID NO: 18 (heavy chain CDR1), SEQ ID NO: 19 (heavy chain CDR2) and SEQ ID NO: 20 (heavy chain CDR3); or d) an antibody comprising a light chain variable region comprising SEQ ID NO: 15 (light chain CDR1), SEQ ID NO: 16 (light chain CDR2), SEQ ID NO: 17 (light chain CDR3) and a heavy chain variable region comprising SEQ ID NO: 18 (heavy chain CDR1), SEQ ID NO: 19 (heavy chain CDR2) and SEQ ID NO: 20 (heavy chain CDR3).