Patent ID: 9624185
Date: 2017-04-18
CPC Classifications: C07D

Claim:
1. A method for preparing epacadostat of formula 1, comprising: (1) contacting a compound of formula 2 with sodium nitrite and hydroxylamine hydrochloride to obtain a compound of formula 3; (2) contacting the compound of formula 3 with a compound of formula 4 to obtain a compound of formula 5; (3) contacting the compound of formula 5 with N,N′-carbonyldiimidazole to obtain a compound of formula 6; (4) contacting the compound of formula 6 with ethyleneimine to obtain a compound of formula 7; (5) contacting the compound of formula 7 with a compound of formula 8 to obtain a compound of formula 9; and (6) contacting the compound of formula 9 with sodium hydroxide to obtain the epacadostat of formula 1;