Patent ID: 9724293
Date: 2017-08-08
CPC Classifications: A61K,A61P

Claim:
1. A method of manufacturing a viscous, non-aqueous, liquid pharmaceutical formulation, comprising: applying a shear rate to a viscous, non-aqueous, liquid-based suspending vehicle sufficient to produce a reduced viscosity liquid-based suspending vehicle; mixing particles comprising a pharmaceutically active agent into the reduced viscosity liquid-based suspending vehicle at a temperature from 80° C. to 120° C., wherein the particles further comprise sucrose, methionine, and citrate buffer; and processing the reduced viscosity liquid-based suspending vehicle to manufacture the viscous, non-aqueous, liquid pharmaceutical formulation, wherein the viscous, non-aqueous, liquid-based suspending vehicle comprises: an amphiphilic molecule; and a solvent selected from the group consisting of: lauryl lactate, lauryl alcohol, benzyl alcohol, benzyl benzoate, 1:1 benzyl benzoate:benzyl alcohol, ethyl hexyl lactate, glycerol formal, tetraglycol, N-1-methyl-2-pyrrolidone, dimethyl sulfoxide, polyethyleneglycol, triglycerides, ethanol, isopropanol, t-butyl alcohol, cyclohexanol, glycerin, glycerol, alpha-tocopherol, vegetable oil, sesame oil, soybean oil, cottonseed oil, and peanut oil wherein the pharmaceutically active agent is selected from the group consisting of a protein or a peptide.