Patent ID: 9707178
Date: 2017-07-18
CPC Classifications: A61K

Claim:
1. A pharmaceutical composition comprising olmesartan medoxomil having a particle size wherein d(0.9) is less than 140 μm, more than 0.1% and less than 1% by weight stearic acid, and degradation products of olmesartan medoxomil that include, but are not limited to, olmesartan acid, wherein olmesartan medoxomil and degradation products of olmesartan medoxomil are the only active ingredients in the pharmaceutical composition wherein each of the constituents incorporated into said composition has a pH less than 8 if measured by a glass electrode in an aqueous solution or suspension containing 1 g of said constituents in 100 g of water at room temperature, and wherein the pharmaceutical composition is coated with a coating where an aqueous solution or suspension containing 1 g of coating in 100 g of water at room temperature has a pH less than 8 if measured by a glass electrode; and wherein when the pharmaceutical composition is exposed to 75% relative humidity at 40° C. in an open dish for one month, the total amount of degradation products of olmesartan medoxomil does not increase more than 1%, and the amount of olmesartan acid does not increase more than 0.3%.