Patent ID: 9693960
Date: 2017-07-04
CPC Classifications: A61K,A61P

Claim:
1. A method of controlling or adjusting release of an active ingredient from a dosage form comprising the active ingredient and a cellulose ether, which method comprises the steps of a) providing at least two compositions, each comprising the same cellulose ether and a different controlled amount of a liquid diluent, based on the dry weight of the cellulose ether, b) subjecting each composition to a simultaneous drying and grinding operation to provide a dried and ground cellulose ether from each composition, and c) incorporating each dried and ground cellulose ether and an active ingredient into a separate dosage form by pressing each cellulose ether, an active ingredient and one or more optional solid adjuvants to separate tablets, d) determining the release rate of the active ingredient from the dosage form, e) establishing the positive correlation between i) the release rate of the active ingredient from each dosage form and ii) the weight ratio between the liquid diluent and the cellulose ether, based on its dry weight, in the compositions of step a), and f) utilizing the established positive correlation to adapt the amount of liquid diluent in the compositions of step a) to a desired release rate of the active ingredient from the dosage form, the composition is subjected in step b) to a simultaneous drying and grinding operation to provide a dried and ground cellulose ether comprising from 0.01 to 0.25 weight parts of liquid diluent per weight part of dry cellulose ether.