Patent ID: 9550704
Date: 2017-01-24
CPC Classifications: A61K,C07B,C07C,C07D,C07H,C07J

Claim:
1. A method for synthesizing a radiopharmaceutical using a polymer-filled cartridge, comprising: passing a radioisotope solution through the polymer-filled cartridge to trap a radioisotope; loading a reaction solution to the cartridge which comprises a solution of a precursor and/or phase transfer catalyst dissolved in solvent; labeling a precursor with the radioisotope entrapped by the cartridge; and eluting a radioisotope-labeled compound from the cartridge to provide the radiopharmaceutical, wherein the cartridge is filled with a polymer and has a structure in which an upper porous frit and a lower porous frit are placed, said polymer being located between the upper and the lower porous frit, the structure having a space over the location of the polymer and wherein the upper porous frit and the lower porous frit are not permeated with the polymer filled within the cartridge, but are permeated with a solution, wherein the polymer has a structure represented by the following Chemical Formula 1-1 or 1-2: wherein, ‘support’ is a non-soluble organic polymer selected from the group consisting of polystyrene, polyethylene glycol, and a combination thereof, or a non-soluble silica; ‘spacer’ is a halogen-substituted or unsubstituted hydrocarbon of C ‘Y’ is a halogen-substituted or unsubstituted organic salt selected from among —NR a triazolium salt and a pyridinium salt wherein R 1 , R 2 , and R 3 , are independently a hydrocarbon of C 1-30 in which at least one element selected from the group consisting of nitrogen, oxygen and sulfur may be intermediated; ‘X’ is tetrafluoroborate (BF ‘W’ is phosphate (—PO ‘Z’ is hydrogen, lithium (Li), sodium (Na), potassium (K), rubidium (Rb), cesium (Cs), or quaternary ammonium salt of —NR