Patent ID: 9598485
Date: 2017-03-21
CPC Classifications: A61K,A61P,C07K

Claim:
1. An isolated antibody that binds to a phosphorylated epitope of Tau protein, wherein the antibody comprises HVR-L1, HVR-L2 and HVR-L3, wherein: (a) HVR-L1 comprises the amino acid sequence X (b) HVR-L2 comprises the amino acid sequence KVX (c) HVR-L3 comprises the amino acid sequence SQTX and wherein the antibody does not comprise an HVR-L1, HVR-L2 and HVR-L3 wherein the HVR-L1 amino acid sequence is RSSQSLVHSHGKTYLH (SEQ ID NO:15) or RSSQRLVHSHGKTYLH (SEQ ID NO:92); the HVR-L2 amino acid sequence is KVSNRFS (SEQ ID NO:16); and the HVR-L3 amino acid sequence is SQTAHFPYT (SEQ ID NO:30).