Patent ID: 9688729
Date: 2017-06-27
CPC Classifications: A61K,A61P,C07K,C12N

Claim:
1. A method of treatment or prophylaxis of Respiratory syncytial virus (RSV) infections comprising the steps: a) Providing the mRNA sequence encoding at least one antigenic polypeptide from the fusion protein F, the nucleoprotein N, the M2-1 protein or the M2-2 protein of RSV, wherein the G/C content of the sequence encoding the antigenic polypeptide is increased compared with the G/C content of the coding region of the wild type mRNA encoding an antigenic polypeptide; and b) applying or administering the mRNA sequence to a subject; wherein the mRNA sequence encoding the antigenic polypeptide comprises a sequence at least 90% identical to one of Seq. Id. Nos. 31, 32, 33, 34, or 35.