Patent ID: 9693959
Date: 2017-07-04
CPC Classifications: A61K,A61P

Claim:
1. A method of controlling or adjusting release of an active ingredient from a dosage form comprising the active ingredient and a polysaccharide derivative, which method comprises the steps of a) providing a composition comprising a polysaccharide derivative and a controlled amount of a liquid diluent, based on the dry weight of the polysaccharide derivative, b) subjecting the composition to a dry-grinding operation to provide a dry-ground polysaccharide derivative, and c) then combining the dry-ground polysaccharide derivative and an active ingredient, and incorporating them into a dosage form, wherein the release of the active ingredient from the dosage form is controlled and adjusted by controlling and adjusting the amount of the liquid diluent, based on the dry weight of the polysaccharide derivative in step a), and wherein the polysaccharide derivative is selected from the group consisting of methyl cellulose, methyl hydroxyethyl cellulose, methyl hydroxypropyl cellulose and hydroxypropyl cellulose, and wherein the release of the active ingredient from the dosage form at a given time is adjusted to a first value by a first amount of the liquid diluent, based on the dry weight of the polysaccharide derivative in step a), and the release of the active ingredient from the dosage form at the given time is adjusted to a second value by a second amount of the liquid diluent, based on the dry weight of the polysaccharide derivative in step a).