Patent ID: 9688716
Date: 2017-06-27
CPC Classifications: C07B,C07J

Claim:
1. A method for preparing a crystalline form of 5α-androstane-3β,5,6β-triol, comprising: dissolving 5α-androstane-3β,5,6β-triol in a solvent to form a mixture, with a ratio of the 5α-androstane-3β,5,6β-triol to the solvent being 1g:10˜120 mL; heating the mixture to 50˜80° C.; adding another solvent to dilute the mixture; cooling the mixture; and allowing the mixture to form a crystalline precipitate, wherein the crystalline form is a transparent needle-shaped crystal, and belongs to monoclinic crystal system and space group P2 wherein the crystalline form is characterized by lattice parameters of a=11.3±0.2 Å, b=7.4±0.2 Å, c=20.5±0.2 Å, α=90.0°, β=95.0±0.5°, γ=90.0°; and characterized by diffraction peaks at diffraction angle 2θ values of 4.3±0.2, 8.6±0.2, 12.9±0.2, 17.2±0.2, 21.6±0.2 degrees; and characterized by an endothermic transition temperature of 223±2° C.