Patent ID: 9605082
Date: 2017-03-28
CPC Classifications: A61K,C07K

Claim:
1. A method for treating or inhibiting a thrombin-mediated thrombosis or embolism, comprising administering to a patient in need thereof an antibody molecule that specifically binds to the exosite 1 region of thrombin and comprises an LCDR1 having the amino acid sequence of SEQ ID NO: 15, an LCDR2 having the amino acid sequence of SEQ ID NO: 8, an LCDR3 having the amino acid sequence of SEQ ID NO: 9, an HCDR1 having the amino acid sequence of SEQ ID NO: 3, an HCDR2 having the amino acid sequence of SEQ ID NO: 4, and an HCDR3 having the amino acid sequence of SEQ ID NO: 5.