Patent ID: 9597433
Date: 2017-03-21
CPC Classifications: A61L,Y10T

Claim:
1. A method of making a modified silicone surface comprising: activating the silicone surface; mixing a plurality of cross-linking dendrimers with a plurality of ligand derivatives to allow binding of dendrimers to ligand derivatives, wherein the plurality of cross-linking dendrimers comprise an alkynylated generation 5 poly(amido amine) dendrimer and the plurality of ligand derivatives comprise azido-poly-N-acetyl-glucosamine; and functionalizing the silicone surface by immobilizing the plurality of the cross-linked dendrimers bound to the plurality of ligand derivatives on the activated silicone surface; and adhering a non-pathogenic biolfilm to the modified silicone surface, wherein the functionalizing provides a ligand-presenting modified silicone surface conducive for the formation and accumulation of a non-pathogenic biofilm.