Patent ID: 9649341
Date: 2017-05-16
CPC Classifications: A61K,A61L,A61P

Claim:
1. A wound healing device comprising an active collagen matrix support material obtained from a tissue of a human, wherein the active collagen matrix is crosslinked and contains growth factors native to the collagen in the tissue and provides a biocompatible surface for cellular growth, the active collagen matrix comprising enzymatically removed proteoglycan groups, the active collagen matrix including a polymer scaffold comprising a material comprising polylactide, polyglycolide, polyglycolic acid, polylactide-co-glycolide, polylactic acid-polyethylene oxide copolymers, modified cellulose, polyhydroxpriopionic acid, polycaprolactone, polycarbonates, polyamides and combinations thereof, wherein the support material comprises a population of osteoblasts, chondrocytes, myocytes, cardiomyocytes, neurons or a combination thereof cultured directly on the support material and the active collagen matrix comprises a leveling agent, wherein a surface of the active collagen matrix is treated with a suspension of another active collagen, and the device comprises polynucleotide compositions and additional growth factors comprising rhBMP12, BMP7, or a combination thereof, different from the growth factors native to the collagen such that the amount of total growth factors is about 30% to about 50% greater than growth factors native to collagen, wherein the active collagen matrix comprises particles having a size from about 25 microns to about 75 microns and the active collagen matrix comprises native growth factors that are active, but excludes viable cells from the tissue.