Patent ID: 9682035
Date: 2017-06-20
CPC Classifications: A61F,A61K,A61L,C12N

Claim:
1. A bone implant primer comprising a biodegradable hydrogel component and biomolecule release depots dispersed within the biodegradable hydrogel component, and wherein a first plurality of biomolecule release depots comprises biomolecules for mitigation of foreign body response including at least one of macrophage chemoattractant protein-1 or its mutant 7-ND, and wherein a second plurality of biomolecule release depots comprises biomolecules for aiding implant osseointegration including at least one of bone morphogenetic protein 2, bone morphogenetic protein 7, vascular endothelial growth factor, platelet-derived growth factor, or fibroblast-derived growth factor, and wherein the first plurality of biomolecule release depots releases biomolecules for mitigation of foreign body response for no more than 12 days, and the second plurality of biomolecule release depots releases biomolecules for implant osseointegration for at least 16 days.