Patent ID: 9545519
Date: 2017-01-17
CPC Classifications: A61B,A61N

Claim:
1. An active interface device comprising: a transducer or sensor array comprising a plurality of transducers or sensors arranged to transform a cell activity into an electrical signal, each transducer or sensor comprising a switch for activating the transducer or sensor; at least one detection unit configured to detect one or more electrical signals generated by the transducer or sensor array, wherein the detection unit comprises at least one comparator configured to compare the one or more electrical signals to a predetermined threshold signal; at least one recording unit configured to record the one or more electrical signals and having a plurality of recording channels to electrically connect to the transducers or sensors in real-time, wherein the recording channels are resources at a disposal of the transducer or sensor array to record cell activity; a first die and a second die coupled to the first die, wherein the plurality of transducers or sensors is arranged on the first die, wherein the plurality of recording channels is arranged on the second die; a three-dimensional via array that provides a plurality of electrical connections through the first die to the second die, wherein the plurality of transducers or sensors are operable to be switchably electrically connected to the plurality of recording channels using at least one electrical connection provided by the three-dimensional via array; at least two amplifying blocks for amplifying the one or more electrical signals, wherein a first amplification is performed by a first amplifying means disposed in the detection unit and a second amplification is performed by a second amplifying means disposed in the recording unit, wherein an amplitude of the predetermined threshold signal is greater than a noise level of the first amplifying means; and at least one control unit configured to: