Patent ID: 9545360
Date: 2017-01-17
CPC Classifications: A61J,A61L,A61M,Y10T

Claim:
1. A filled package comprising: a vessel having a lumen defined at least in part by a wall, the wall having an interior surface facing the lumen and an outer surface; a barrier coating of SiO x , wherein x is from 1.5 to 2.9, from 2 to 1000 nm thick, the barrier coating of SiO x having an interior surface facing the lumen and an outer surface facing the wall interior surface, the barrier coating being effective to reduce the ingress of atmospheric gas into the lumen compared to an vessel without a barrier coating; a protective coating of a saccharide, the protective coating of a saccharide having an interior surface facing the lumen and an outer surface facing the interior surface of the barrier coating, the protective coating of a saccharide being effective to increase the calculated shelf life of the package (total Si/Si dissolution rate); and a fluid composition contained in the lumen and having a pH between 5 and 9; wherein the calculated shelf life of the package is more than six months at a storage temperature of 4° C.