Patent ID: 9670547
Date: 2017-06-06
CPC Classifications: A61K,C12Q,C40B,G16B,G16H

Claim:
1. A method of diagnosing and treating an individual as having a DNA damage response deficient (DDRD) cancer comprising: a. measuring expression levels of at least five biomarkers in a test sample of cancer cells obtained from the individual, wherein the at least five biomarkers are selected from the group consisting of CXCL10, MX1, IDO1, IFI44L, CD2, GBP5, PRAME, ITGAL, LRP4, and APOL3; b. deriving a combined test score that captures the expression levels; c. providing a threshold score comprising information correlating the test score and a diagnosis of the cancer; wherein the individual is diagnosed as having the DDRD cancer when the test score exceeds the threshold score; and d. treating the diagnosed individual with a DNA-damage therapeutic agent.