Patent ID: 9606130
Date: 2017-03-28
CPC Classifications: C12Q,G01N

Claim:
1. A method of diagnosis or of quantitation of fibrosis comprising: obtaining a patient biofluid sample, conducting an immunoassay to measure fragments of collagen type III having an N- or C-terminal neo epitope formed by cleavage of intact collagen type III by MMP1, MMP2, MMP3, MMP8, MMP9, MMP13, CathepsinK, CathepsinS, ADAMTS1, ADAMTS4, ADAMTS5, or ADAMTS8, said fragments being naturally present in said sample, and associating an elevation of said measure in said patient above a normal level with the presence or extent of fibrosis, wherein said immunoassay is conducted by a method comprising: or wherein said immunological binding partner specifically binds to a C-terminal neo epitope amino acid sequence formed by cleavage of collagen type III by MMP1, MMP2, MMP3, MMP8, MMP9, MMP13, CathepsinK, CathepsinS, ADAMTS1, ADAMTS4, ADAMTS5, or ADAMTS8, wherein said C-terminal amino acid sequence is selected from the group consisting of: