Patent ID: 9724383
Date: 2017-08-08
CPC Classifications: A61K,A61P,C07K,C12N

Claim:
1. A method of inhibiting the fusion of a human immunodeficiency virus (HIV) to a target cell comprising: administering a trimeric polypeptide pharmaceutical composition to the target cells, wherein the composition comprises a trimeric polypeptide, wherein the trimeric polypeptide comprises three polypeptide monomers, each polypeptide monomer consisting of a fusion peptide consisting of the amino acid sequence of the N-terminal heptad repeat (NHR or HR1) of the transmembrane glycoprotein gp41 of HIV fused to a foldon trimerization motif, wherein the NHR is N28, and wherein the foldon trimerization motif sequence is fused to the C-terminus of the NHR; and inhibiting fusion of the virus to the cell.