Patent ID: 9739786
Date: 2017-08-22
CPC Classifications: C07D,C07K,G01N

Claim:
1. A method for aiding in the diagnosis of irritable bowel syndrome (IBS) and a clinical subtype thereof in a subject by generating a series of at least three biomarker scores (a) through (f) from a sample, said method comprising (a) detecting in a sample obtained from said subject the level of at least one bacterial antigen antibody marker to obtain a microbiome score; (b) detecting in said sample the level of at least one mast cell marker to obtain a mast cell score; (c) detecting in said sample the level of at least one inflammatory cell marker to obtain an inflammatory score; (d) detecting in said sample the level of at least one bile acid malabsorption (BAM) marker to obtain a BAM score; (e) detecting in said sample the level of at least one kynurenine marker to obtain an oxidative stress score; (f) detecting in said sample the level of at least one serotonin marker to obtain a serotonin score; and (g) applying a statistical algorithm to said at least three scores, wherein the at least three scores include the bile acid malabsorption score, the serotonin score, and the oxidative stress score, wherein the sample is from a subject with IBS or is suspected of having IBS.