Patent ID: 9622976
Date: 2017-04-18
CPC Classifications: A61K

Claim:
1. A pharmaceutical composition comprising more than one first unit, selected from the group consisting of granules, pellets, and tablet cores; wherein said more than one first unit comprises a first active pharmaceutical ingredient together with pharmaceutically acceptable excipients and more than one second unit, selected from the group consisting of granules, pellets and tablet cores, wherein said more than one second unit comprises a second active pharmaceutical ingredient, together with pharmaceutically acceptable excipients, wherein said more than one first unit and more than one second unit are combined together with a suitable carrier and compressed into a tablet where said units are substantially evenly distributed throughout the tablet; wherein the second active pharmaceutical ingredient is 6-chloro-3,4-dihydro-2H-1,2,4-benzotiadiazine-7-sulfonamide-1,1-dioxide and the more than one first unit alone imparts a pH above 8 to a 1% by weight aqueous solution or dispersion of the more than one first unit, where said more than one first unit comprises 2-[4-[[4-methyl-6-(1-methylbenzoimidazol-2-yl)-2-propyl-benzoimidazol-1-yl]methyl]phenyl] benzoic acid or a salt thereof as the first active pharmaceutical ingredient, and wherein the more than one second units further comprise an acidifying agent and wherein the more than one second unit alone imparts a pH below 6 to a 1% by weight aqueous solution or dispersion of the more than one second unit.