Patent ID: 9693954
Date: 2017-07-04
CPC Classifications: A61F,A61K,A61P

Claim:
1. A method for promoting cartilage regeneration, comprising: contacting a target site of a subject with a device comprising a polymeric scaffold comprising a first and a second spatially distinct restricted zones, wherein the first zone comprises a purified morphogen that promotes cartilage regeneration, and wherein the second zone comprises a purified inhibitor of the morphogen; wherein the morphogen and the inhibitor are released from the device into the target site; wherein the morphogen promotes cartilage regeneration over a sustained period of time at a spatially restricted first region of the target site contacted by the first zone, thereby creating a field of action; and wherein the inhibitor inhibits the activity of the morphogen at a spatially restricted second region of the target site contacted by the second zone, thereby creating a boundary between the first region and the second region of the target site defining where cartilage regeneration is promoted.