Patent ID: 9585933
Date: 2017-03-07
CPC Classifications: A61K,A61P,C07K

Claim:
1. A method of treating a condition of the heart, lungs, or blood vessels connecting the heart and the lungs mediated by Nox2 in a patient, comprising decreasing superoxide anion production by Nox2 in an amount and duration effective to relieve one or more symptoms of the condition in the patient by administering to the patient by inhalation an aerosolized polypeptide consisting of: a) a 9-12 amino acid fragment comprising the amino acid sequence CSTRVRRQL (SEQ ID NO: 4) and b) a tat cell penetration peptide, wherein the tat cell penetration peptide is conjugated to the amino acid fragment, and wherein the condition is one or more of right ventricular hypertrophy, pulmonary hypertension, acute lung injury, obstructive sleep apnea, ischemia/reperfusion injury in the lung, and pulmonary fibrosis.