Patent ID: 9683018
Date: 2017-06-20
CPC Classifications: A61K,A61P,C07K

Claim:
1. A cyclic polypeptide having the following formula I (SEQ ID NO: 1): wherein: X1 is the N-terminus of the polypeptide and is absent or is selected from A, Q and pE; X5 is L or X5 is selected from C, c, hC and D-hC; wherein the side chain of C, c, hC or D-hC forms a disulfide bond with the side chain of X12; X6 is S, s or a; X7 is H, Aib or a; or X7 is selected from C, c, hC and D-hC; wherein the side chain of C, c, hC or D-hC forms a disulfide bond with the side chain of X12; X9 is G or X9 is selected from C, c, hC and D-hC; wherein the side chain of C, c, hC or D-hC forms a disulfide bond with the side chain of X12; wherein only one of X5, X7 or X9 is selected from C, c, hC and D-hC; X11 is D-Nle, Nle, M or f; and X12 is selected from C, c, hC, D-hC; wherein the side chain of C, c, hC or D-hC forms a disulfide bond with the side chain of C, c, hC or D-hC of either X5, X7 or X9; X13 is the C-terminus and is absent or is selected from (N-Me)F, F, f, a, y and Nal; wherein: Nle is L-norleucine; D-hC is D-homocysteine hC is L-homocysteine; Nal is L-naphathaline; Aib is 2-aminoisobutyric acid; pE is L-pyroglutamic acid; or an amide, an ester or a salt of the polypeptide.