Patent ID: 9592302
Date: 2017-03-14
CPC Classifications: A61K,A61P,C08F,C08J,Y10S

Claim:
1. A nano-assembly for controlled delivery of a therapeutic or diagnostic agent to a biological site, comprising: a water-soluble polymer host comprising a crosslinked network of a random co-polymer having the structural formula: wherein p is an integer from about 1 to about 20, the co-polymer has a molecular weight from about 1,000 to about 100,000, the ratio of i:j is in the range from about 2:8 to about 8:2, and from about 1% to about 95% of j is substituted by k, a guest molecule comprising a therapeutic, diagnostic, or imaging agent non-covalently associated with the polymer host, wherein the therapeutic or diagnostic agent is releasable upon partial or complete de-crosslinking of the crosslinked network of polymer molecules at or near the biological site, and a targeting moiety selected from an antibody, an aptamer, a peptide, and a small molecule ligand, covalently linked to or non-covalently associated with the polymer host.