Patent ID: 9549903
Date: 2017-01-24
CPC Classifications: A61K,A61P

Claim:
1. A method of treating pain in a patient comprising applying a transdermal therapeutic system for the transdermal administration of buprenorphine to the skin of the patient, wherein the transdermal therapeutic system comprises a buprenorphine-containing self-adhesive layer structure comprising a. a buprenorphine-impermeable backing layer, and b. a buprenorphine-containing pressure-sensitive adhesive layer on the buprenorphine-impermeable backing layer, the adhesive layer comprising wherein the transdermal therapeutic system provides a size of the buprenorphine-containing pressure-sensitive adhesive layer providing an area of release ranging from about 1 cm 2 to about 4.8 cm 2 and contains an amount of the buprenorphine from about 1 mg to about 4 mg buprenorphine base or an equimolar amount of a pharmaceutically acceptable salt thereof, and wherein the transdermal therapeutic system provides a mean AUCt per area of release of more than 1,700 pg.hr/ml-cm 2 over about 168 hours of administration after a single-dose administration to a subject population.