Patent ID: 9532996
Date: 2017-01-03
CPC Classifications: A61K,A61P

Claim:
1. A modified release oral composition comprising: i. about 35 mg to less than about 50 mg of a doxycycline, based on the equivalent weight of doxycycline base, ii. one or more water soluble and insoluble polymers, and iii. one or more pharmaceutically acceptable excipients, wherein the doxycycline is in an amount of about 15-20% w/w, the water soluble and insoluble polymers are in an amount of about 10-18% w/w and the pharmaceutically acceptable excipients are in an amount of about 1-20% w/w, based on the total weight of the composition, and said composition is free of any immediate release component, and said composition when subjected to a changeover dissolution study, releases no more than 30% by weight in 30 minutes, in 750 ml of pH 1.2 acidic solution; and has at least one of the following release profile in 950 ml of pH 6.0 buffer solution: