Patent ID: 9675592
Date: 2017-06-13
CPC Classifications: A61K,A61P

Claim:
1. A method for inhibiting a staphylococcus infection comprising administering to a subject having a staphylococcus infection or at risk of a staphylococcus infection: (a) an antibiotic, and; (b) an antibiotic potentiator, wherein the antibiotic potentiator is a compound of the formula: wherein R 1 may be -(4-chlorophenoxy)methyl, 1-(thiophen-2-yl)cyclopentyl, 1,2,3,4-tetrahydronaphthalen-6-yl, 1-isopropyl-1H-pyrazol-5-yl, 2-(thiophen-2-yl)quinolin-4-yl, 2,3-dihyrdobenzo[b][1,4]dioxin-6-yl, 2,4-dichlorophenyl, 2,5-dichlorophenyl, 2,5-dichlorothiophen-3-yl, 2,6-difluorophenyl, 2-bromothiophen-5-yl, 2-chlorothiophen-5-yl, 2-naphthyl, 2-phenoxyphenyl, 2-phenylquinolin-4-yl, 2-tolyl, 3-(2-chlorophenyl)-5-methylisoxazol-4-yl, 3,4,5-trimethoxyphenyl, 3,5-dichlorophenyl, 3,5-dimethoxyphenyl, 3-bromophenyl, 3-chlorobenzo[b]thiophen-2-yl, 3-chlorophenyl, 3-fluorophenyl, 3-methoxyphenyl, 3-n-butoxyphenyl, 3-phenoxyphenyl, 3-tolyl, 3-trifluoromethylphenyl, 4-(2,6-dimethylmorpholinosulfonyl)phenyl, 4-(2-ethylpiperidin-1-ylsulfonyl)phenyl, 4-(2-methylpiperidin-1-ylsulfonyl)phenyl, 4-(2-phenylquinoline), 4-(3,4-dihydroisoquinolin-2(1H)-ylsulfonyl)phenyl, 4-(3,4-dihydroquinolin-1(2H)-ylsulfonyl)phenyl, 4-(3,5-dimethylpiperidin-1-ylsulfonyl)phenyl, 4-(4,4-dimethyloxazolidin-3-ylsulfonyl)phenyl, 4-(morpholinosulfonyl)phenyl, 4-(N,N-diallylsulfamoyl)phenyl, 4-(N,N-diethyl sulfamoyl)phenyl, 4-(N,N-diisobutylsulfamoyl)phenyl, 4-(N,N-dimethylsulfamoyl)phenyl, 4-(N-ethyl-N-benzyl sulfamoyl)phenyl, 4-(N-ethyl-N-n-butyl-sulfamoyl)phenyl, 4-(N-ethyl-N-phenyl sulfamoyl)phenyl, 4-(N-isopropyl-N-benzylsulfamoyl)phenyl 4-(N-methyl-N-benzylsulfamoyl)phenyl, 4-(N-methyl-N-cyclohexylsulfamoyl)phenyl, 4-(N-methyl-N-n-butyl sulfamoyl)phenyl, 4-(N-methyl-N-phenylsulfamoyl)phenyl, 4-(piperidin-1-ylsulfonyl)phenyl, 4-(pyrrolidin-1-ylsulfonyl)phenyl, 4-benzoylphenyl, 4-benzylphenyl, 4-biphenyl, 4-chlorophenyl, 4-diphenyl, 4-ethoxyphenyl, 4-fluorophenyl, 4-phenoxyphenyl, 4-tert-butylphenyl, 7-methoxybenzofuran-2-yl, benzo[d]thiazol-2-yl, benzo[d]thiazol-4-yl, benzo[d]thiazol-6-yl, benzofuran-2-yl, diphenylmethyl, methyl-4-benzoate, phenyl, or thiophen-2-yl, and R 2 may be 1,2,3,4-tetrahydronaphthalen-6-yl, 2-(methylthio)phenyl, 2,3-dihydro-1,4-dioxin-2-yl, 2,3-dihydrobenzo[b][1,4]-dioxin-2-yl, 2,3-dihydrobenzo[b][1,4]-dioxin-6-yl, 2,4-dichlorophenyl, 2,4-dimethoxyphenyl, 2,4-dimethylphenyl, 2,5-dichlorophenyl, 2,5-dichlorothiophen-3-yl 2,5-dimethylphenyl, 2-bromothiophen-2-yl, 2-chlorophenyl, 2-chlorothiophen-2-yl, 2-chlorothiophen-5-yl, 2-furanyl, 2-methoxyphenyl, 2-pyridinyl, 3-(methylthio)phenyl, 3,4,5-trimethoxyphenyl, 3,4-dimethoxyphenyl, 3,4-dimethylphenyl, 3,5-dimethoxyphenyl, 3-methoxyphenyl, 3-pyridinyl, 4-chlorophenyl, 4-(methylthio)phenyl, 4-bromophenyl, 4-ethoxyphenyl, 4-fluorophenyl, 4-isopropylbenzyl, 4-methoxybenzyl, 4-methoxyphenyl, 4-pyridinyl, 4-trifluoromethoxyphenyl, 7-ethoxybenzofuran-2-yl, 7-methoxybenzofuran-2-yl, benzofuran-2-yl, benzyl, phenyl, or thiophen-2-yl, or an antibiotic potentiator having the structure: or an antibiotic potentiator having the formula: wherein R may be 2-phenoxyphenyl, 2-bromothiophen-5-yl, or 2,5-dichlorophenyl; or an antibiotic potentiator having the formula: wherein R may be fluoro, or chloro, or an antibiotic potentiator having the structure: or an antibiotic potentiator having the structure: or an antibiotic potentiator having the structure: or an antibiotic potentiator having the structure: or an antibiotic potentiator having the structure: or an antibiotic potentiator having the structure: or an antibiotic potentiator having the structure: or an antibiotic potentiator having the formula: wherein R 1 may be N-(4-(phenylamino)-N′-(phenyl)acetamide)amine, N-3-(N′,N′-dimethylamine)propylamine, N-(4-N′-phenylacetamide)amine, or hydroxyl, and R 2 may be tert-butyl, isopropyl, or phenyl, and R 3 may be hydrogen or chloro, or an antibiotic potentiator having the structure: or an antibiotic potentiator having the formula: wherein R may be 1H-indazol-6-yl, or 3-(4-methoxyphenoxy)methyloxadiazol-5-yl-methyl, or an antibiotic potentiator having the formula: wherein, R 1 and R 2 may each be separately hydrogen, methyl, chloro or methylthio, or a prodrug or comparable salt thereof.