Patent ID: 9610582
Date: 2017-04-04
CPC Classifications: A61K,B01L,G01N

Claim:
1. A microfluidic device comprising: a fluid exchange module in a first substrate, the fluid exchange module comprising a corresponding first microfluidic channel and a first array of island structures in the first microfluidic channel, the first array of island structures being arranged in one or more rows that extend along a longitudinal direction of the first microfluidic channel, each island structure in a row being spaced apart from an adjacent island structure in the row to form an opening, wherein the first array of island structures in the fluid exchange module is configured and arranged to shift portions of fluid through the opening between adjacent island structures within a row; and a particle concentration module in a second substrate, the particle concentration module comprising a corresponding second microfluidic channel and a second array of island structures, each island structure in the second array of island structures being spaced apart from an adjacent island structure in the second array of island structures to form an opening, wherein the second array of island structures in each particle concentration module is configured and arranged to shift portions of fluid through the openings between adjacent island structures in the second array of island structures toward a first side of the second array of island structures, and to focus particles contained within the product fluid along one or more streamlines on a second opposite side of the second array of island structures.