Patent ID: 9701715
Date: 2017-07-11
CPC Classifications: A61K,C07K,C12N

Claim:
1. A cell-targeting compound comprising: one or more of the peptides having a conformationally-constraining portion, and a kinked portion linked through a peptide linker to the conformationally-constraining portion that conformationally constrains the kinked portion, the kinked portion, peptide linker and conformationally-constraining portion includes one of SEQ ID NOs: 5-38, 40-54 or 61-69; and a targeting moiety linked to an end of the peptide, wherein: the kinked portion has an amino acid sequence that includes one or more amino acids independently selected from proline and glycine; the conformationally-constrained portion includes one or more 2-aminoisobutyric acid residues; and the peptide linker includes one or more natural or non-natural amino acids, essential amino acids, or non-essential amino acids, or amino acids having L or D configuration or peptide thereof.