Patent ID: 9645155
Date: 2017-05-09
CPC Classifications: A61K,B01J,C07C,C07K,G01N

Claim:
1. A method of making a γ-AApeptide library, the method comprising: a. providing a plurality of synthetic beads functionalized to react with γ-AApeptide building blocks; b. splitting the beads into a predetermined number of groups and placing each group in a separate reaction vessel; c. adding a different γ-AApeptide building block to each reaction vessel and reacting the γ-AApeptide building block with the beads, wherein each γ-AApeptide building block has the structure of compound X and wherein the R for the γ-AApeptide building block for each reaction vessel is different from that for every other reaction vessel and is selected from the group consisting of: any amino acid side chain; d. pooling the bead/γ-AApeptide compounds from each reaction vessel together, then splitting the pooled bead/γ-AApeptide compounds into the predetermined number of groups, and placing each group into a separate reaction vessel; e. removing the alloc protection groups from the bead/γ-AApeptide compounds; f. adding a different acylating agent to each reaction vessel, wherein each acylating agent includes an R′ group, and wherein the R′ for each different acylating agent is independently selected from the group consisting of: any amino acid side chain, g. pooling the bead/acylated γ-AApeptide compounds from each reaction vessel together, then splitting the pooled bead/acylated γ-AApeptide compounds into the predetermined number of groups, and placing each group into the separate reaction vessels; h. repeating steps c-g n−1 number of times; and i. removing all protecting groups to obtain a library of different γ-AApeptide compounds having a structure of Formula I: wherein, for each γ-AApeptide compound, n is an integer between 1 and about 20, the bracketed portion of Formula I is a repeating unit, except for the identity of R and R′, and R and R′ are as defined above and are independently selected for each repeating unit.