Patent ID: 9534003
Date: 2017-01-03
CPC Classifications: C07F,C07H,C07J,Y02P

Claim:
1. An amino linker building block suitable for preparing 5′ amino-modified oligonucleotides comprising a linker covalently bonded between a phosphoramidite moiety and an amino protecting group, wherein the amino protecting group comprises a 1,4-diamide substructure, with two amide groups comprising a C1 and a C4 carbon atom of the 1,4-diamide substructure, wherein the 1,4 diamide substructure is part of an aromatic system in which two neighboring carbon atoms of the aromatic system constitute a 2- and 3- position of the 1,4-diamide substructure, and wherein a nitrogen of one of the amide groups is covalently bonded to the linker and the nitrogen of the other of the two amide groups is not bonded to the linker.