Patent ID: 9623125
Date: 2017-04-18
CPC Classifications: A61K,C07K,C08G

Claim:
1. A process for obtaining polyglutamates by means of controlled polymerization of N-carboxyanhydrides (NCAs) of alpha-amino acids using a nucleophilic salt of tetrafluoroborato as an initiator according to the reaction: wherein: R represents an alkyl group, a C-terminal attachment group selected from an alkyne, an azide, a thiol, a halide, an activated thiol, an alkene, an activated ester, an activated alcohol, a protected amine, a maleimide group, an acetal, and an activated carboxylic acid, ethylene glycol (EG), or polyethylene glycol having a molecular weight of from 100 to 20,000 g/mol; n X represents BF