Patent ID: 9649425
Date: 2017-05-16
CPC Classifications: A61B,A61M,B82Y,C12Q,G01N,Y10T

Claim:
1. A system comprising a fluid bypass configured to passage fluids including one or more cell types from a vertebrate subject into a device and configured to return the passaged fluids to the vertebrate subject, wherein the device includes a quasi-planar substrate; and two or more laterally-mobile effector molecule types at least partially embedded within the quasi-planar substrate, wherein the two or more laterally-mobile effector molecule types are sequentially placed and configured to interact with one or more cell types; one or more sensors configured to detect the at least one aspect of the interaction between the two or more laterally-mobile effector molecule types and the one or more cell types; and a controller in communication with the one or more sensors, wherein the controller is configured to responsively initiate modification of at least one of the two or more laterally-mobile effector molecule types, the quasi-planar substrate, or the one or more cell types sufficient to initiate activation, maturation, differentiation, anergy induction, antigen loading, binding, electroporation, or transduction in the one or more cell types.