Patent ID: 9701718
Date: 2017-07-11
CPC Classifications: A61K,A61P,C07K,C12N

Claim:
1. A method of inducing a protective immune response against Ebola in a subject, the method comprising: administering to the subject, as a priming vaccination, an immunologically effective amount of a recombinant adenovirus vector comprising a polynucleotide encoding a first filovirus antigenic protein, wherein the recombinant adenovirus vector is an rAd26 vector; followed by administering a boosting vaccination to the subject that includes an adenovirus vector comprising a polynucleotide encoding a second filovirus antigenic protein, wherein the adenovirus vector is an rAd35 vector, so as to induce durable T-cell memory in the subject for the first and second filovirus antigenic proteins and thus immunizing the subject against Ebola, wherein each of the first and second filovirus antigenic proteins is a glycoprotein from an Ebola virus; and wherein, three weeks following the boosting vaccination, the subject has an anti-Ebola glycoprotein EC90 antibody titer of at least 1:32,000.