Patent ID: 9636352
Date: 2017-05-02
CPC Classifications: A61K,A61P

Claim:
1. A method of treating a musculoskeletal disease or disorder comprising the step of administering to a subject in need thereof an effective amount of a composition comprising a citrate compound or a pharmaceutically acceptable salt thereof that is complexed with a metal ion, wherein the musculoskeletal disease or disorder is posttraumatic osteoarthritis, and wherein the citrate compound has the following formula: where X is one of the following: wherein Y is a citrate moiety, O, OH, NH, or R; Y′and Y″ are independently a citrate moiety, O, O—Y, OH, NH, NH—Y, R or R—Y, with R being an alkyl, alkene, ester, or aryl group having from 1 to 6 carbon atoms; and Z is a carboxyl group, H, or R.