Patent ID: 9579291
Date: 2017-02-28
CPC Classifications: A01N,A61K

Claim:
1. A carrier for the controlled release of an active agent at a target environment, comprising: a core, comprising surface-reacted natural or synthetic calcium carbonate having an inter-particle porosity of from 40 vol.-% (v/v) to 60 vol.-% (v/v), and an intra-particle porosity of from 30 vol.-% (v/v) to 50 vol.-% (v/v), calculated from a mercury porosimetry measurement, 0.1 to 5 wt. % of a lubricant based on the weight of the surface-reacted calcium carbonate and/or 0.5 to 10 wt. % of a disintegrant based on the weight of the surface-reacted calcium carbonate, and at least one active agent, wherein a sufficient amount of the at least one active agent is adsorbed onto and/or absorbed into the natural or synthetic surface-reacted calcium carbonate, and wherein the surface-reacted natural or synthetic calcium carbonate is a reaction product of natural or synthetic calcium carbonate with carbon dioxide and one or more acids, wherein the carbon dioxide is formed in situ by the acid treatment and/or is supplied from an external source, and a coating encapsulating the core that is selected to protect the active agent and/or facilitate controlled release of the active agent in a target environment.