Patent ID: 9675521
Date: 2017-06-13
CPC Classifications: A61J,A61K,A61P

Claim:
1. A method for producing a drug-block copolymer composite comprising a poorly water-soluble drug and a block copolymer including a hydrophilic segment and a hydrophobic segment bonded together, wherein the hydrophilic segment is polyethylene glycol or a derivative of polyethylene glycol, and the hydrophobic segment is a derivative of polyaspartic acid or a derivative of polyglutamic acid, the method comprising: mixing the poorly water-soluble drug and the block copolymer in one or more non-aqueous solvents; heating the mixture; and spray-drying the resulting mixture liquid in a gas flow environment maintained at a temperature lower than or equal to the melting point of the block copolymer, wherein the gas flow environment employed for the spray-drying is at a temperature of 20° C. or lower, wherein the drug-copolymer composite produced by the method forms micelles in water, and said micelles have an average particle size of about 30 nm to 150 nm as measured by using a dynamic light scattering method.