Patent ID: 9714298
Date: 2017-07-25
CPC Classifications: A61K,A61P,C07K,G01N

Claim:
1. An antibody or a functional fragment thereof, comprising a heavy chain and a light chain, the heavy chain comprising: (i) a CDRH1 comprising SEQ ID NO: 58; (ii) a CDRH2 comprising SEQ ID NO: 59; and (iii) a CDRH3 comprising SEQ ID NO: 60 or an amino acid sequence derived from SEQ ID NO: 60 by one amino acid substitution at the first amino acid position and/or one amino acid substitution at the second amino acid position; and the light chain comprising (i) a CDRL1 comprising SEQ ID NO: 67; (ii) a CDRL2 comprising SEQ ID NO: 68; and (iii) a CDRL3 comprising SEQ ID NO: 69, wherein the antibody or functional fragment thereof has antibody-dependent cellular cytotoxic activity and binds to human fibroblast growth factor receptor 2 (human FGFR2) IIIb and human fibroblast growth factor receptor 2 (human FGFR2) IIIc.