Patent ID: 9694127
Date: 2017-07-04
CPC Classifications: A61M,B01D

Claim:
1. A bioreactor device comprising: a housing having a blood inlet port; a blood outlet port; an hemofiltrate inlet port; and an hemofiltrate outlet port; one or more porous hollow fiber membranes contained within said housing, each of said one or more hollow fiber membranes being in fluid communication with said blood inlet port and said blood outlet port, and each of said one or more hollow fiber membranes comprising a hemocompatible luminal surface and a cytocompatible exterior surface that is cytocompatible for human primary renal proximal tubule cells (HPTCs) or stem cell-derived HPTC-like cells, each of said cytocompatible exterior surfaces covered with a confluent layer of said HPTCs or stem cell-derived HPTC-like cells, and being in fluid communication with said hemofiltrate inlet port and said hemofiltrate outlet port.