Patent ID: 9579299
Date: 2017-02-28
CPC Classifications: A61K,A61P

Claim:
1. A method of reducing a side-effect of a central nervous system (CNS) active agent, the method comprising: administering at least one CNS active agent selected from the group consisting of a benzodiazepine, a muscle relaxant, and an anti-psychotic to a patient; and administering at least two vagal neuromodulators to the patient in an amount sufficient to reduce a side-effect of the CNS active agent, wherein the at least two vagal neuromodulators comprise at least one mechanoreceptor stimulator and at least one adrenomimetic, wherein the at least one mechanoreceptor stimulator and/or adrenomimetic is administered or released at least about 5 minutes after the CNS active agent is administered or released and the side-effect is selected from the group consisting of sedation, somnolence, and sleepiness.