Patent ID: 9745629
Date: 2017-08-29
CPC Classifications: A61K,A61Q,C12Q,C12Y,G01N

Claim:
1. A method for screening for candidate compounds that increase the expression level of HS6ST2 in keratinocytes, comprising the following steps: (a) bringing at least one test compound in contact with a sample of keratinocytes in vitro; (b) measuring the expression of the HS6ST2 gene, in said keratinocytes from step (a); and (c) further testing the at least one test compound in an in vitro or in vivo model for its effects on skin aging and/or skin hydration when the expression of the HS6ST2 gene measured in the keratinocytes treated in (a) is increased by at least 1.4 fold compared with the expression level of HS6ST2 in the a sample of untreated keratinocytes.