Patent ID: 9561225
Date: 2017-02-07
CPC Classifications: A61K,A61P

Claim:
1. A controlled release oral dosage form comprising: a therapeutically effective amount of an opioid analgesic, from about 10 ng to 275 mg of an opioid antagonist, and particles consisting of a gelling agent, one or more pharmaceutically acceptable hydrophobic material(s) selected from the group consisting of cellulose polymers, acrylic polymers, polylactic acid, polyglycolic acid and a co-polymer of the polylactic acid and polyglycolic acid, and one or more additional pharmaceutically acceptable excipient(s), wherein the gelling agent is releasable from said particles and a solubilized mixture having a viscosity of at least about 10 cP is formed when the dosage form is crushed and dissolved in from about 1 to about 5 ml of water, a weight ratio of the gelling agent to the opioid analgesic is from about 1:40 to about 40:1, and the gelling agent is polyethylene oxide.