Patent ID: 9573999
Date: 2017-02-21
CPC Classifications: A61K,A61P,C07K

Claim:
1. A method for treating lung carcinoma in a patient comprising administering to the patient a CTLA-4 antibody according to a dosage escalation regimen and a chemotherapeutic agent, wherein the dosage escalation regimen comprises: (a) administering a first CTLA-4 antibody dosage of from about 3 mg/kg to about 10 mg/kg and then administering one or more increased dosages of the CTLA-4 antibody at a maximum dose of about 10 mg/kg to the patient until a complete response is observed in the patient, wherein the complete response is disappearance of the measurable lung carcinoma for greater than or equal to one month, and observing the complete response comprises measuring the lung carcinoma using an imaging study; and (b) when the patient experiences a complete response, giving two additional administrations of the CTLA-4 antibody at the dosage level that resulted in the complete response, wherein the CTLA-4 antibody comprises a heavy chain variable region that comprises CDR1, CDR2, and CDR3 domains; and a light chain variable region that comprises CDR1, CDR2, and CDR3 domains, wherein the heavy chain variable region CDR1 comprises amino acids having the sequence set forth in SEQ ID NO: 1; the heavy chain variable region CDR2 comprises amino acids having the sequence set forth in SEQ ID NO:2; the heavy chain variable region CDR3 comprises amino acids having the sequence set forth in SEQ ID NO:3; the light chain variable region CDR1 comprises amino acids having the sequence set forth in SEQ ID NO:4; the light chain variable region CDR2 comprises amino acids having the sequence set forth in SEQ ID NO:5; and the light chain variable region CDR3 comprises amino acids having the sequence set forth in SEQ ID NO:6.