Patent ID: 9744244
Date: 2017-08-29
CPC Classifications: A61K,C07K,C12N,C12Y

Claim:
1. An amphipathic cell penetrating peptide of less than approximately 50 amino acid residues comprising one of the following amino acid sequences: or a fragment thereof, said fragment comprising at least 6 arginine residues (R), at least 12 Alanine Residues (A), at least 6 leucine residues (L), optionally at least one cysteine residue (C), and at least two but no greater than three glutamic acids (E) wherein the arginine (R) residues are evenly distributed at every third or fourth amino acid position along the entire length of the peptide; the ratio of arginine (R) to negatively charged glutamic acid (E) residues is from at least 6:2 to 9:2; and the ratio of hydrophilic amino acid residues to hydrophobic amino acid residues at pH 7 is at least 30:67 to 40:60.