Patent ID: 9622975
Date: 2017-04-18
CPC Classifications: A61K,A61P

Claim:
1. An oral pharmaceutical composition in compressed tablet form comprising: i. parathyroid hormone (PTH) or a fragment thereof comprising at least amino acids 1 to 28 in an amount of about 1 μg/kg to about 6 μg/kg body weight: ii. N-(5-chlorosalicyloyl)-8-aminocaprylic acid (5-CNAC) in an amount of between 40 wt % and 60 wt % as delivery agent; (iii) crospovidone as a disintegrant in an amount of from 1.0 wt % to 8 wt %; and (iv) Avicel as a diluent in an amount of from 20 wt % to 70 wt %; wherein the composition has a disintegration time of no more than 6 minutes and a dissolution of >90% at 20 minutes and wherein the tablet has a hardness of between 3 Kp and 20 Kp.