Patent ID: 9649282
Date: 2017-05-16
CPC Classifications: A61K,A61P

Claim:
1. A composition comprising: (a) at least one acid salt of an active pharmaceutical ingredient (API) with the structure of Structure I where R1 is H or OH; R2 is H or CH3; R3 is H or CH3; R4 is H, OH or OCH3; R5 is H, OH or OCH3; and R6 is H or OCH3; (b) a first compound coupled to the acid salt of the API to form a water-insoluble complex, and enabling the first compound to undergo oxidization under basic conditions, to form a fine particulate precipitate; and (c) a second compound in an amount sufficient for coupling to the first compound in an aqueous environment, whereby the acid salt of the API is released from the complex.