Patent ID: 9738681
Date: 2017-08-22
CPC Classifications: C07F,C07H,Y02P

Claim:
1. A method of producing a compound of formula (III): or a salt thereof, comprising reacting a compound of formula (IVb): with a trimethylsilylating agent to produce a trimethylsilylated compound; and reacting the trimethylsilylated compound with a compound of formula (II): or a salt thereof, wherein A is an alkylene group having 1 to 4 carbon atoms; B is a purin-9-yl group or a purin-9-yl group having one or more substituents selected from group α; X, Y, and Z are each independently a protective group for the hydroxy group; R is a silyl protective group; R group α is a hydroxy group, a protected hydroxy group, an alkoxy group having 1 to 4 carbon atoms, a mercapto group, a protected mercapto group, an alkylthio group having 1 to 4 carbon atoms, an amino group, a protected amino group, an amino group substituted by one or more alkyl groups having 1 to 4 carbon atoms, an alkyl group having 1 to 4 carbon atoms, or a halogen atom.