Patent ID: 9549920
Date: 2017-01-24
CPC Classifications: A61K,A61P

Claim:
1. A method of treating or preventing post-operative pain in a patient in need of such treatment, the method comprising administering one or more biodegradable drug depots comprising a polymer comprising poly(D,L-lactide-co-caprolactone) in an amount of about 30 wt. % of the one or more drug depots, and a therapeutically effective amount of a local anesthetic or pharmaceutically acceptable salt thereof in an amount of about 60 wt. % of the one or more drug depots to a target tissue site beneath the skin before, during or after surgery, wherein the one or more drug depots is capable of releasing an initial bolus dose of the local anesthetic or pharmaceutically acceptable salt thereof at a site beneath the skin followed by a sustained release dose of an effective amount of the local anesthetic or pharmaceutically acceptable salt thereof over a period of at least 4 days, and the one or more drug depots further comprising an excipient comprising methoxy polyethylene glycol (mPEG) in an amount of about 10 wt. % of the one or more drug depots, and the one or more drug depots further comprises trehalose.