Patent ID: 9603354
Date: 2017-03-28
CPC Classifications: A01N,A61P

Claim:
1. A protective solution for avoiding ischemic damage to organs, or to isolated cell systems, or to tissue components after perfusion, surgery, transplantation, or cryoconservation and subsequent reperfusion, which solution comprises the following components: (i) sodium at a concentration of about 10 mmol/l to about 120 mmol/l; (ii) magnesium at a concentration of about 3 mmol/l to about 27 mmol/l; (iii) calcium at a concentration of about 0.0001 mmol/l to about 1.5 mmol/l; (iv) chloride; (v) n-acetyl histidine; (vi) sucrose; (vii) a-ketoglutarate at a concentration of about 1 mmol/l to about 9 mmol/l; (viii) aspartate in an amount in excess of chloride; (ix) glycine; (x) arginine; (xi) deferoxamine; and (xii) 3,4-dimethoxy-N-methyl-benzohydroxamic acid; wherein said solution has an osmolarity of about 290 Osm/l to about 350 mOsm/l, as well as a pH value of about 6.8 to about 7.4; wherein the maximum concentration of aspartate is about 140 mmol/l; wherein the maximum concentration of arginine is about 140 mmol/l; wherein the maximum concentration of deferoxamine is about 10 mmol/l; and wherein the maximum concentration of 3,4-dimethoxy-N-methyl-benzohydroxamic acid is about 10 mmol/l.