Patent ID: 9611480
Date: 2017-04-04
CPC Classifications: A61P,C12N

Claim:
1. A method for treating a heart disease in a subject having a heart disease associated with decreased expression of peroxisome proliferator activator receptor delta (PPARδ), the method comprising: administering to a subject in need thereof a pharmaceutically effective amount of a modified antisense molecule against microRNA (miR)-199a-5p or miR-214, the modified antisense molecule comprising the sequence according to SEQ ID NO:18, SEQ ID NO:19, or a nucleic acid molecule consisting of 15 to 23 linked nucleosides having at least 90% sequence identity to the sequence of SEQ ID NO:18or SEQ ID NO: 19; wherein the modified antisense molecule reduces expression or activity of miR-199a-5p or miR-214 in cardiac muscle cells; and wherein PPARδ expression levels are increased or restored after administration, thereby treating the heart disease.