Patent ID: 9301980
Filing Date: 2016-04-05
CPC Classification: A61K,A61L,A61P,C12N

Claim Text:
1. A composition of isolated enhanced human bone graft material comprising enhanced cells wherein the enhanced cells have an increased level of expression for one or more biomarkers comprising Runx2, Osterix, Osteocalcin, alkaline phosphatase, Axin2, Lef1, or Tcf4 after exposure ex vivo with a liposome comprising a Wnt protein, wherein the increased level of expression for the one or more biomarkers is relative to equivalent cells from isolated human bone graft material unexposed to a liposome comprising a Wnt protein, and wherein the isolated enhanced human bone graft material is obtained from a human subject at least 50 years of age or older.