Patent ID: 9244082
Filing Date: 2016-01-26
CPC Classification: A61P,C07K,C12Q,G01N

Claim Text:
1. An assay kit for detecting autoantibodies to the low density lipoprotein receptor-related protein 4 (LRP4) polypeptide in a bodily fluid of a subject, the kit comprising an isolated LRP4 polypeptide or isolated fragment thereof; wherein the fragment thereof comprises the extracellular domain of the LRP4 polypeptide, the intracellular domain of the LRP4 polypeptide, one or more of the epidermal growth factor (EGF) repeats of the LRP4 polypeptide, and/or one or more of the low density lipoprotein receptor (LDLR) repeats of the LRP4 polypeptide; and wherein the isolated LRP4 polypeptide or isolated fragment thereof is immobilized on a solid surface, wherein the solid surface comprises a bead or biochip.