Patent ID: 9427474
Filing Date: 2016-08-30
CPC Classification: A61K,A61P,C07F,C07K

Claim Text:
1. A conjugate comprising a polymeric backbone having attached thereto an anti-angiogenesis agent and a bisphosphonate bone targeting moiety, said polymeric backbone being derived from a polymer selected from the group consisting of dextran, a water soluble polyamino acid, a polyethylenglycol (PEG), a polyglutamic acid (PGA), a polylactic acid (PLA), a polylactic-co-glycolic (PLGA), a poly(D,L-lactide-co-glycolide) (PLA/PLGA), a polyglycerol, a polyamidoamine (PAMAM), and a polyethylenimine (PEI), the conjugate being represented by the general formula I: wherein: x is an integer having a value such that x/(x+y+w) multiplied by 100 is in the range of from 70 to 99.8; y is an integer having a value such that y/(x+y+w) multiplied by 100 is in the range of from 0.1 to 15; and w is an integer having a value such that w/(x+y+w) multiplied by 100 is in the range of from 0.1 to 15, A B is said anti-angiogenesis agent; D is said bone targeting moiety; and each of the L such that [A [A wherein each of the [A