Patent ID: 9295663
Filing Date: 2016-03-29
CPC Classification: A61K,A61L,A61M,A61P

Claim Text:
1. A method for coating a balloon catheter, the method comprising: forming a homogeneous coating solution by dissolving a hydrophobic drug having a solubility in phosphate buffered saline of about 1 mg/ml or less than 1 mg/ml in a coating solvent comprising one or more first solvents in which the drug has a solubility of not more than 2000 mg/liter and one or more second solvents in which the drug has a solubility of not less than 10,000 mg/liter, disposing the coating solution over a surface of the balloon of the balloon catheter; removing the one or more second solvents at a temperature and pressure selected such that the drug precipitates from the remaining coating solution as particles of a volume weighted average diameter of 30 microns or less; and removing the remaining coating solvent; wherein the coating solution further comprises a suspending agent/surfactant, a binder, or both; wherein the drug is selected from the group consisting of zotarolimus, everolimus, sirolimus, biolimus A9, deforolimus, ridaforolimus, tacrolimus, temsirolimus, pimecrolimus, novolimus, myolimus, paclitaxel, protaxel, and combinations thereof; wherein the one or more first solvent(s) is/are selected from the group consisting of water, ethylene glycol, propylene glycol, glycerol, n-butyl alcohol, 2-butyl alcohol, furfuryl alcohol, formamide, methylformamide, and dimethylformamide; and wherein the one or more second solvent(s) is/are selected from the group consisting of methanol, ethanol, isopropanol, 1-propanol, acetone, 2-butanone, diethyl ether, tetrahydrofuran, methyl acetate, and ethyl acetate.