Patent ID: 9315866
Filing Date: 2016-04-19
CPC Classification: C12Q

Claim Text:
1. A method to detect that test cells of a subject are those of an HPV-induced high-grade precancerous lesion or of HPV-induced invasive carcinoma associated with T-lymphocyte maturation associated protein (MAL), said method comprising measuring the expression level of the gene encoding the MAL protein; and detecting the level of methylation of the CADM1 promoter and/or CpG rich CADM1 genomic sequence in said test cells obtained from said subject, wherein a decrease in said level of expression combined with increased methylation of the CADM1 promoter and/or CpG rich CADM1 genomic sequence in said test cells as compared to normal cells detects that said cells are of an HPV-induced high-grade precancerous lesion or of an HPV-induced invasive carcinoma associated with T-lymphocyte maturation associated protein (MAL).