Patent ID: 9422344
Filing Date: 2016-08-23
CPC Classification: A61K,A61P,A61Q,C07K,C12Y,Y02A

Claim Text:
1. A transport protein, obtained by modification of the heavy chain of a Clostridium botulinum type A (BoNT/A), said heavy chain comprising a H N -fragment and a H C -fragment, wherein the H C fragment corresponding to amino acids 867-1296 of Clostridium botulinum neurotoxin type A (BoNT/A) protein sequence of SEQ ID NO: 1, 14, 15 or 16 is substituted by a H C fragment corresponding to amino acids 866-1291 of Clostridium botulinum neurotoxin type B (BoNT/B) protein sequence of SEQ ID NO: 17, 18, 19, 20, 21, or 22.