Patent ID: 9260722
Filing Date: 2016-02-16
CPC Classification: A61K,A61P,C12N,G01N

Claim Text:
1. A hepatocyte or stem cell comprising: a) one or more exogenous expression cassettes comprising a FOXA2 gene, a HNF1A gene and one or more additional hepatocyte programming factor genes selected from the group consisting of HHEX, HNF4A, FOXA1, TBX3-1, GATA4, NR0B2, SCML1, CEBPB, HLF, HLX, NR1H3, NR1H4, NR1I2, NR1I3, NR5A2, SEBOX, and ZNF391 genes; and b) a reporter expression cassette comprising a hepatocyte-specific promoter operably linked to a reporter gene.