Patent ID: 9273030
Filing Date: 2016-03-01
CPC Classification: A61P,C07B,C07D,Y10T

Claim Text:
1. A process for preparing the compound of Formula-1, or a pharmaceutically acceptable salt thereof, the process comprising: a) reacting 2-aminopyridine with ethyl acrylate at a temperature of 95-100° C. to prepare the compound of Formula-4, b) reacting the compound of Formula-8 with methyl amine to provide the compound of Formula-5, c) condensing the compound of Formula-5 with the compound of Formula-4 obtained in step (a) in a solvent selected from hydrocarbon solvents, chloro solvents, ester solvents, polar aprotic solvents, ether solvents, alcoholic solvents, ketone solvents, nitrile solvents, nitro solvents or polar solvents, or mixtures thereof, to provide the compound of Formula-6, d) reducing the compound of Formula-6 in-situ with a reducing agent selected from Fe-acetic acid or Fe-hydrochloric acid in a solvent selected from hydrocarbon solvents, chloro solvents, ester solvents, polar aprotic solvents, ether solvents, alcoholic solvents, ketone solvents, nitrile solvents, nitro solvents or polar solvents, or mixtures thereof, to provide the compound of Formula-7, e) reacting the compound of Formula-7 with the compound of Formula-9 in presence of a condensing agent selected from pivaloyl chloride, polyphosphoric acid, carbodiimides, alkyl or aryl chloroformates, 3-hydroxy-3,4-dihydro-1,2,3-benzotriazin-4-one, diethylphosphorocyanidate (DEPC), diphenylphosphoroazidate (DPPA), P f) treating the compound of Formula-10 with an ammonia source selected from formamide, ammonium carbamate, ammonium formate, ammonium phosphate, ammonium acetate, ammonium fluoride, ammonium bromide, ammonium chloride, ammonium iodide, ammonium iodate, ammonium carbonate, ammonium citrate, ammonium chromate, ammonium dichromate, ammonium hydroxide, ammonium lactate, ammonium molybdate, ammonium nitrate, ammonium oxalate, ammonium sulfate, ammonium sulfide, ammonium tartrate, ammonium triflate, ammonium thiocyanate, ammonium dihydrogen phosphate, urea, methyl carbamate, ethyl carbamate, propyl carbamate or t-butte carbamate and/or ammonia gas in presence of hydrogen chloride gas and Lewis acid in a solvent selected from hydrocarbon solvents, chloro solvents, ester solvents, polar aprotic solvents, ether solvents, alcoholic solvents, ketone solvents, nitrile solvents, nitro solvents or polar solvents, or mixtures thereof, to provide compound of Formula-11, g) reacting n-hexanol and N,N-carbonyldiimidazole in a solvent selected from hydrocarbon solvents, chloro solvents, ester solvents, polar aprotic solvents, ether solvents, alcoholic solvents, ketone solvents, nitrile solvents, nitro solvents or polar solvents, or mixtures thereof, to provide an amide compound; and h) reacting the amide compound of step-(g) in-situ with the compound of Formula-11 in presence of a base selected from an inorganic base or an organic base or a mixture thereof in a solvent selected from hydrocarbon solvents, chloro solvents, ester solvents, polar aprotic solvents, ether solvents, alcoholic solvents, ketone solvents, nitrile solvents, nitro solvents or polar solvents, or mixtures thereof, to provide the compound of Formula-1.