Patent ID: 9310378
Filing Date: 2016-04-12
CPC Classification: C12Q,G01N,Y10T

Claim Text:
1. A Matrix-Assisted Laser Desorption/Ionization mass spectrometry substrate, comprising a support that includes an array of spots, some or all of which spots comprise: (i) a matrix material for Matrix-Assisted Laser Desorption/Ionization mass spectrometry of nucleic acids, wherein the matrix material is selected from among 3-hydroxypicolinic acid, di-ammoniumcitrate or a mixture of 3-hydroxypicolinic acid and di-ammoniumcitrate and; (ii) an additive that comprises ascorbic acid, or a salt, tautomer or analog thereof, in an amount that reduces the amount of an adduct formed under Matrix-Assisted Laser Desorption/Ionization mass spectrometry conditions, wherein the analog of ascorbic acid is according to the following formula: wherein: R R