Patent ID: 9388243
Filing Date: 2016-07-12
CPC Classification: A61P,C07K

Claim Text:
1. A method of target membrane protein depletion, the method comprising treating a cell with a dual binding molecule comprising a first binding domain which binds to a driver membrane protein on the cell surface and a second binding domain which binds to a target membrane protein on the cell surface, wherein the driver membrane protein is c-Met; the first binding domain is an anti-c-Met antibody or antigen-binding antibody fragment thereof that specifically binds to an epitope comprising 5 or more contiguous amino acids within the SEMA domain of c-Met protein comprising the amino acid sequence of SEQ ID NO: 73; and the second binding domain is an antibody, antigen-binding antibody fragment, or DARPin; and wherein the driver membrane protein and target membrane protein are internalized into the cell and degraded when the first binding domain of the dual binding molecule binds the driver membrane protein and the second binding domain binds the target membrane protein.