Patent ID: 9474787
Filing Date: 2016-10-25
CPC Classification: A61K,A61P,C12N

Claim Text:
1. An isolated non-genetically modified human cell differentiated ex vivo from a mesenchymal stem cell under conditions such that the isolated non-genetically modified human cell expresses at least one mesenchymal stem cell marker and secretes brain-derived neurotrophic factor (BDNF) and glial derived neurotrophic factor (GDNF), and does not secrete nerve growth factor (bNGF), wherein said at least one mesenchymal stem cell marker is selected from the group consisting of CD73, CD90 and CD105, wherein a basal secretion of said GDNF is at least two times greater than a basal secretion of said GDNF in a non-differentiated, non-genetically modified human mesenchymal stem cell.