Patent ID: 9441246
Filing Date: 2016-09-13
CPC Classification: A61P,C12N

Claim Text:
1. A chimeric adeno-parvovirus vector characterized in that it comprises an entire parvovirus genome inserted into an adenovirus genome, wherein: (a) The adenovirus genome is characterized by deletion of E1 and E3; and (b) the activity of a parvovirus P4 early promoter, which regulates the expression of a nonstructural parvovirus protein (NS) is modified to repress or block the NS protein expression in a packaging cell line during chimera production but is fully functional in cancer cells with respect to the activity of a wild-type parvovirus P4 early promoter, wherein the parvovirus P4 early promoter is modified by inserting two tetracycline operator 2 elements between a TATA box and a NS start codon.