Patent ID: 9387243
Filing Date: 2016-07-12
CPC Classification: A61K,A61P,C07K,C12N

Claim Text:
1. A therapeutic vaccine composition, comprising a recombinant Bordetella pertussis adenylate cyclase (CyaA) protein comprising: the HPV16-E7 fragment GQAEPDRAHYNIVTFCCKCDSTLRLCVQSTHVDIRTLEDLLMGTLGIVCPICSQKP (SEQ ID NO: 25) inserted at a first insertion site within the CyaA protein; and the HPV16-E7 fragment MHGDTPTLHEYMLDLQPETTDLYCYEQLN (SEQ ID NO: 26) inserted at a second insertion site within the CyaA protein; wherein the enzymatic activity of the recombinant CyaA protein has been genetically inactivated; and wherein administering the therapeutic vaccine composition to a mammalian subject infected with HPV prevents HPV-induced tumor growth in the subject.