Patent ID: 9274127
Filing Date: 2016-03-01
CPC Classification: C12Q,G01N

Claim Text:
1. A method for determining depression, wherein an amount of a serotonin transporter including an amount of an ubiquitinated serotonin transporter in a blood sample treated with a proteasome inhibitor is defined as an amount of an inhibitor-treated serotonin transporter, and an amount of a serotonin transporter in an untreated blood sample is defined as an amount of an untreated serotonin transporter, the method comprising: a step of analyzing the amount of the inhibitor-treated serotonin transporter and the amount of the untreated serotonin transporter in a blood sample collected from a subject; a step of comparing the difference between the amount of the untreated serotonin transporter and the amount of the inhibitor-treated serotonin transporter obtained from the blood sample collected from the subject (the difference between the untreated and inhibitor-treated amounts), and the difference between the untreated and inhibitor-treated amounts obtained from blood sampling of one or more healthy subjects; and a step of determining that the subject has depression when the difference between the untreated and inhibitor-treated amounts obtained from the blood sample collected from the subject is smaller than the difference between the untreated and inhibitor-treated amounts obtained from the blood sampling of the one or more healthy subjects.