Patent ID: 9511026
Filing Date: 2016-12-06
CPC Classification: A61K,A61P

Claim Text:
1. A method for preparing a poorly soluble drug containing microsphere, comprising a) dissolving a water-soluble polymer carrier and a poorly soluble drug in water and an organic solvent to prepare a mixed solution; and b) spray drying the mixed solution, wherein the mixed solution does not include a surfactant, the weight ratio of the organic solvent and water is 0.5:1 to 5:1, and the poorly soluble drug is fenofibrate, and wherein the spray drying is conducted at a spray temperature of 80 to 120° C., a spray speed of 3,000 to 5,000 rpm, and an injection speed of 10 to 100 ml/min, using an atomizer type spray dryer, and wherein the weight ratio of the organic solvent and water is 1:1 to 3:1 wherein the water-soluble polymer carrier is hydroxypropylmethylcellulose (HPMC), and the organic solvent is ethanol.