Patent ID: 9504676
Filing Date: 2016-11-29
CPC Classification: A61K,A61P,G01N

Claim Text:
1. A method for treating a type I hypersensitivity reaction or an autoimmune disease dependent on metabolic pathways involving spleen tyrosine kinase (Syk) in a human, which comprises administering a compound to the human, wherein said compound is (a) compound C-13having the following formula (b) an organic compound functionally equivalent to compound C-13 having a molecular weight between 50 and 2500 Daltons, selected from substituted compounds of C-13, wherein one or more atoms belonging to a carbon chain, an aromatic group, a cycle or a heterocycle of C-13 substituted via a covalent bond by one or a plurality of halogens, and/or by one or a plurality of aromatic, cyclic, heterocyclic, alkyl, alkoxy, carboxyl, carbonyl, primary, secondary or tertiary amine, amide or sulphonamide groups; or (c) a stereo-isomer, racemate or pharmacologically acceptable salt of C-13 or of said functionally equivalent compound; wherein said functionally equivalent compound binds with Syk tyrosine kinase protein at a site located outside the catalytic domain of such protein, on a three-dimensional cavity situated between both SH2 domains and inter-domain A of Syk, wherein said three-dimensional cavity comprises the arginine residue situated in position 68 and the two glutamic acid residues situated in positions 121 and 155 of human Syk tyrosine kinase protein, the sequence of which is set forth in SEQ ID No: 1; and wherein said functionally equivalent compound is capable of inhibiting by at least 10% in vitro binding of antibody fragment G4G11 (SEQ) ID No: 2), with human Syk tyrosine kinase protein.