Patent ID: 9463222
Filing Date: 2016-10-11
CPC Classification: A61K,A61P

Claim Text:
1. A method for reducing the risk of developing a complication of preterm birth comprising administering to a preterm infant having a serum level of IGF-1 and IGFBP-3 below the in utero normal for the same gestational age, an effective amount of IGF-1 in combination with IGFBP-3, wherein the molar ratio of IGF-1 to IGFBP-3 is lower than equimolar, in the range from 1:20 to 1:3.33, thereby elevating the preterm infant's IGF-1 and IGFBP-3 serum levels to normal in utero levels, wherein the complication of preterm birth is selected from the group consisting of bronchopulmonary dysplasia, intraventricular hemorrhage and retinopathy of prematurity (ROP).