Patent ID: 9492404
Filing Date: 2016-11-15
CPC Classification: A61K,A61P

Claim Text:
1. A method for decreasing of tau phosphorylation and/or aggregation in a subject, comprising administering to a subject in need thereof having a tauopathy a therapeutically effective amount of an oxygenated ionic aqueous solution of charge-stabilized oxygen-containing nanobubbles having an average diameter of less than 100 nanometers and stably configured in the ionic aqueous fluid in an amount sufficient for decreasing of tau phosphorylation and/or aggregation in the subject, and wherein the tauopathy is at least one selected from the group consisting of argyorphilic grain disease, frontotemporal dementia, progressive supranuclear palsy, corticobasal degeneration, frontotemporal lobar degeneration (Pick's disease), and Dementia pugilistica (DP), and wherein the oxygen in the fluid is present in an amount of at least 15 ppm at atmospheric pressure.