Patent ID: 9265720
Filing Date: 2016-02-23
CPC Classification: A61K,A61P

Claim Text:
1. A method of treating insomnia in an individual by sublingual administration of a pharmaceutical composition, the method comprising: providing the pharmaceutical composition in a dosage form comprising a tablet sized for placement under a tongue, wherein the pharmaceutical composition comprises (a) carrier particles having exterior surfaces, (b) particles of zolpidem or a pharmaceutically acceptable salt thereof sized smaller than the carrier particles and presented, at least in part, upon the exterior surfaces of the carrier particles and said particles of zolpidem or salt thereof cover at least 90% of the exterior surfaces of said carrier particles; and (c) particles of a mucoadhesion promoting agent sized smaller than the carrier particles and presented, at least in part, upon the exterior surfaces of the carrier particles, wherein both the particles of zolpidem or a pharmaceutically acceptable salt thereof and the particles of the mucoadhesion promoting agent are presented, at least in part, upon the exterior surfaces of the carrier particles; and sublingually administering the pharmaceutical composition to the individual to treat the insomnia by placing the tablet under the tongue of the individual, wherein sublingual administration of the pharmaceutical composition provides a therapeutic outcome comprising (i) a measurable plasma concentration of zolpidem within 10 minutes of sublingual administration; and (ii) a time difference following sublingual administration between a first measurable plasma concentration of zolpidem and a maximum measured plasma concentration of zolpidem that is within a range of about 80 minutes to about 160 minutes; and (iii) a plasma concentration of zolpidem that is capable of maintaining sleep for at least about 6 hours after sublingual administration; wherein said individual is thereby treated for insomnia.