Patent ID: 9360472
Filing Date: 2016-06-07
CPC Classification: A61N,B01J,C40B,G01N

Claim Text:
1. A system for screening drug candidates to identify their effects on a cell membrane voltage-gated ion channel, the system comprising: a) a recombinant mammalian cell genetically modified to express a light responsive ChR2 ion channel comprising an amino acid sequence having at least 75% amino acid sequence identity to SEQ ID NO:1 and a heterologous microbial light-responsive ion pump, wherein the cell comprises a voltage-gated ion channel and a fluorescence producing voltage sensor; b) a chemical delivery device for introducing the drug candidates to be screened; c) an optical delivery device to activate the light responsive ion channel or ion pump; d) an optical sensor to monitor fluorescence produced by the voltage sensor; e) a processor to process data received from the optical sensor; and f) memory for storing the data received from the optical sensor.