Patent ID: 9381176
Filing Date: 2016-07-05
CPC Classification: A61K,A61P

Claim Text:
1. A method for increasing insulin secretion from beta cells of a diabetic individual, the method comprising administering to the individual a therapeutic combination comprising therapeutically effective amounts of (1) a compound that directly or indirectly activates adenylate cyclase and (2) an E prostanoid 3 receptor antagonist that attenuates G alpha-i-subfamily-mediated adenylate cyclase inhibition, whereby the beta cells secrete more insulin after the therapeutic combination is administered than before, and wherein the amount of insulin secreted by the beta cells is increased relative to that secreted by beta cells of a diabetic individual not receiving the combination or receiving either the adenylate cyclase-activating compound or the E prostanoid 3 receptor antagonist alone, wherein the diabetic individual is an individual who fails to achieve a glycosylated hemoglobin target of less than 7% after receiving the agent that activates adenylate cyclase without receiving the E prostanoid 3 receptor antagonist.