Patent ID: 9370481
Filing Date: 2016-06-21
CPC Classification: A61K,A61P

Claim Text:
1. A pharmaceutical composition comprising a first and second unit, the active ingredient of the first unit consisting of a parietal cell activator, wherein the parietal cell activator is one or more small carboxylic acid molecules, or salts thereof that activate parietal cells, wherein the small carboxylic acid molecules or salts thereof are saturated or non-saturated monocarboxylic, dicarboxylic, or tricarboxylic acid molecules or salts thereof having between three to six carbon atoms selected from the group consisting of maleic acid, succinic acid, citric acid, pyruvate, fumarate, alpha ketoglutarate, succinyl-CoA and oxaloacetate and wherein the small carboxylic acids are in solid form, and the active ingredient of the second unit consisting of an irreversible gastric H + /K + -ATPase proton pump inhibitor (PPI) wherein the PPI is formulated as particles that are enteric coated, wherein the PPI is formulated for absorption in the small intestine, wherein the first and second units are physically separated, wherein the parietal cell activator is in an amount between 200 to 600 mg and the PPI is selected from the group consisting of esomeprazole, lansoprazole, pantoprazole, rabeprazole, dontoprazole, perprazole (s-omeprazole magnesium), habeprazole, ransoprazole, pariprazole, tenatoprazole, leminoprazole, neutral forms thereof, salt forms thereof, single enantiomers thereof, isomers thereof, other derivatives thereof, and alkaline salts of enantiomers thereof in an amount of 1 to 400 mg, and wherein the composition is suitable for administration to a human patient, the first unit releasing at least 50% of the small carboxylic acid molecules in the stomach in an amount sufficient to activate parietal cells located in the gastric lumen, while the PPI is in the patient's blood having been absorbed through the small intestine, such that the activity of the PPI is synchronized with the parietal cell activity of the small carboxylic acid molecule in the stomach, wherein the carboxylic acid molecules in conjunction with the PPI reduces gastric acid secretion in the stomach, wherein the first unit is an internal capsule containing the small carboxylic acid molecule and the second unit is an external capsule containing the PPI, wherein the internal capsule is encapsulated within the external capsule.