Patent ID: 9493822
Filing Date: 2016-11-15
CPC Classification: C12Q

Claim Text:
1. A device for the specific selection of target molecules, comprising: at least one reaction zone comprising a microarray, wherein the microarray comprises a substrate, on which substrate one or more species of capture molecules are immobilized, wherein the target molecules interact with the capture molecules in the reaction zone, the reaction zone further comprising one or more temperature regulating units for regulating the temperature within the reaction zone; at least one non-bound zone, wherein non-bound target molecules that did not interact with the capture molecules are reactivated in the non-bound zone, the non-bound zone comprising one or more temperature regulating units for regulating the temperature within the non-bound zone a fluid connection region, in which the reaction zone is in fluid connection with the non-bound zone; at least one pump for pumping a fluid through the fluid connection region and between said reaction zone and said non-bound zone, wherein the fluid carries the non-bound target molecules; mixing structures in the fluid connection region for mixing the fluid; wherein the reaction zone, the non-bound zone and the pump are arranged in a closed loop so that fluid is pumped between the reaction zone and the non-bound zone; and wherein the non-bound zone comprises a meandering flow path, wherein at least 40% of the device comprises the meandering flow path, and wherein the meandering flow path has a bifurcation leading to an internal loop having a pump for repetitive passing of the fluid through the meandering flow path.