Patent ID: 9364553
Filing Date: 2016-06-14
CPC Classification: A61K,A61P,C07K,C08G,C08L

Claim Text:
1. A synergistic biomolecule-polymer conjugate comprising the formula: wherein M is a biologically active biomolecule; wherein x is the number of cleavable-linkage polymers coupled to said biomolecule and x≧1; wherein n≧2; wherein P is a polymer or polymer lipid; wherein P n are multiple polymeric arms or pieces wherein their types and sizes may be the same or different; wherein L n is a functional linkage moiety comprising at least one cleavable linkage and at least one permanent linkage; or L n are all cleavable linkages; wherein R is a non-cleavable spacer connected between polymer and the biomolecule; and C is a coupling group attached to the biomolecule, wherein said synergistic biomolecule-polymer conjugate is cleaved in human blood plasma so that biologically active cleavage products are released.