Patent ID: 9320809
Filing Date: 2016-04-26
CPC Classification: A61K,A61P,Y10S

Claim Text:
1. A nanoparticle comprising a hydrophobic drug conjugated to a cationic biocompatible polymer and a hydrophilic drug conjugated to an anionic biocompatible polymer, and forming a self-assembly by a balance between a cation and an anion, wherein the anionic biocompatible polymer is hyaluronic acid, wherein the cationic biocompatible polymer is one or more selected from the group consisting of polylysine, polyhistidine, and polyarginine, wherein the hydrophobic drug is one or more selected from the group consisting of vinblastine, etoposide, alkeran, cytoxan, daunorubicin, hydrea, mithramycin, mitomycin, mitoxantrone, nitrogen mustard, velban, vincristine, carboplatinum, idarubicin, irinotecan, leustatin, navelbine, taxotere, topotecan, adriamycin, daunomycin, and paclitaxel, and wherein the hydrophilic drug is one or more selected from the group consisting of busulfan, chlorambucil, cyclophosphamide, melphalan, cisplatin, ifosfamide, cytarabine, 5-fluorouracil (5-FU), methotrexate (MTX), actinomycin D, bleomycin, and gemcitabine wherein conjugation between the hydrophobic drug and the cationic biocompatible polymer occurs through an ester, imine, hydrazone, acetal, or cyclic acetal linkage, and wherein conjugation between the hydrophilic drug and the anionic biocompatible polymer occurs through an ester, imine, hydrazone, acetal, or cyclic acetal linkage.