Patent ID: 9497945
Filing Date: 2016-11-22
CPC Classification: A01K,A61P,C12N,C12Q,C12Y,G01N

Claim Text:
1. A rodent, comprising a humanization of an endogenous rodent Dpp4 gene, wherein the humanization comprises a replacement at the endogenous rodent Dpp4 locus of a rodent gene encoding an exon of an Dpp4 gene with a nucleic acid sequence encoding at least one exon of a human DPP4 gene to form a modified DPP4 gene, wherein expression of the modified DPP4 gene is under control of rodent regulatory elements at the endogenous rodent Dpp4 locus, wherein the rodent is a mouse or a rat, and wherein the rodent exhibits one or more symptoms when infected with Middle East respiratory syndrome coronavirus (MERS-CoV).