Patent ID: 9493552
Filing Date: 2016-11-15
CPC Classification: A61K,A61P,C07K

Claim Text:
1. A conjugate comprising a tissue factor (TF) having an amino acid sequence at least 95% identical to SEQ ID NO:1 conjugated to an antibody, wherein the antibody comprises: a) complementarity determining regions (CDR) 1-3 of the heavy chain variable region (HCVR) comprising the amino acid sequence of SEQ ID NO:3, and CDRs 1-3 of the light chain variable region (LCVR) comprising the amino acid sequence of SEQ ID NO: 4, and wherein the antibody specifically binds to an extracellular domain epitope of a mammalian plasmalemma vesicle associated protein (PLVAP) having the sequence set forth in SEQ ID NO:25; or b) CDRs 1-3 of the HCVR comprising the amino acid sequence of SEQ ID NO:5, and CDRs 1-3 of the LCVR comprising the amino acid sequence of SEQ ID NO:6, and wherein the antibody specifically binds to an extracellular domain epitope of a mammalian PLVAP having the sequence set forth in SEQ ID NO:26.