Patent ID: 9365900
Filing Date: 2016-06-14
CPC Classification: C12Q

Claim Text:
1. A method for detecting CpG methylation of SIM2-single-minded homolog 2(Drosophila) gene - for bladder carcinoma or bladder cell proliferative disorder diagnosis in a human subject, the method comprising determining hypermethylation of the CpG of the SIM2 gene in genomic DNA isolated from a clinical sample by contacting the sample with primer(s) comprising a DNA sequence selected from the group consisting of SEQ ID NO: 19, 20, 41 and 42 to amplify a methylated CpG of the SIM2 gene, wherein a bladder carcinoma or bladder cell proliferative disorder is detected in the human subject based on increased CpG methylation of the SIM2 gene relative to that of a control.