Patent ID: 9399678
Filing Date: 2016-07-26
CPC Classification: A61K,A61P,C07K

Claim Text:
1. A polypeptide comprising a first antibody single domain that binds TNF-alpha, said first domain comprising a first light chain variable domain (VL), wherein said first light chain variable domain comprises the amino acid sequence of SEQ ID NO:1 (VL18), or a TNF-alpha-binding fragment or a de-immunized derivative thereof, said de-immunized derivative formed by elimination of at least one T a second antibody single domain—that binds TNF-alpha, said second domain comprising a second light chain variable domain or a TNF-alpha-binding fragment or a de-immunized derivative thereof, said de-immunized derivative formed by elimination of at least one T wherein said first and said second single domains together form a dimer.