Patent ID: 9260759
Filing Date: 2016-02-16
CPC Classification: A61K,A61P,C12Q

Claim Text:
1. A method of decreasing the dose of a chemotherapeutic agent for the treatment of cancer expressing Mullerian Inhibiting Substance Receptor II (MISRII), the method comprising administering to the subject a therapeutically effective amount of a pyrazoloanthrone compound and at least one or a combination of chemotherapeutic agents selected from the group consisting of: paclitaxel, cisplatin, doxorubicin, rapamycin, Mullerian Inhibiting Substance (MIS) or recombinant human MIS (rhMIS), wherein the therapeutically effective dose of the chemotherapeutic agent for an apoptotic effect on a cancer cell expressing MISRII in the presence of the pyrazoloanthrone compound is lower as compared to the therapeutically effective dose of the chemotherapeutic agent for the same apoptotic effect on a cancer cell expressing MISRII in the absence of the pyrazoloanthrone compound.