Patent ID: 9475891
Filing Date: 2016-10-25
CPC Classification: C08F

Claim Text:
1. A process for the preparation of colesevelam and/or pharmaceutically acceptable salts thereof comprising: (a) reacting a polyallylamine solution with two alkylating agents to form an alkylated polyallylamine; and (b) crosslinking the alkylated polyallylamine from step (a) with epichlorohydrin to form colesevelam, wherein one of the two alkylating agents is selected from a group consisting of n-decyl bromide, n-decyl chloride, n-decyl tosylate, n-decyl mesylate, n-decyl triflate, n-decyl iodide, n-decyl fluoride, and a combination thereof; and wherein the other of the two alkylating agents is selected from a group consisting of 6-bromohexyl trimethyl ammonium bromide, 6-chlorohexyl trimethyl ammonium chloride, and a combination thereof; wherein the alkylation step (a) and the crosslinking step (b) are conducted in water or an aqueous solvent mixture.