Patent ID: 9422561
Filing Date: 2016-08-23
CPC Classification: A61K,C12N,C12Y

Claim Text:
1. A method for treating an age-related disease comprising administering to a human subject above the age of 50 in need thereof an effective amount of an agent which increases the activity of sirtuin-6 (SIRT6) by increasing the expression of the SIRT6 gene, wherein the agent inhibits binding of a SIRT6 expression inhibitor to a 3′UTR region of human mRNA encoding SIRT6, wherein the expression inhibitor binds to nucleotides 479-486, of SEQ. ID NO. 2, and wherein the age-related disease is selected from the group consisting of: neurodegenerative disease, cancer, type 2 diabetes, hypertension, ocular disorders, cataracts, glaucoma, osteoporosis, blood clotting disorders, arthritis, hearing loss, stroke and Alzheimer's disease.