Patent ID: 9416371
Filing Date: 2016-08-16
CPC Classification: A61K,A61P,C12N,Y02A

Claim Text:
1. A method for inducing or stimulating a T cell mediated immune response to an exogenous T cell antigen in epithelial tissues of a human subject comprising administering to the epithelial tissue of the subject a live, modified, non-replicating poxvirus expressing the antigen to cause a local infection in the epithelial skin tissue in an amount sufficient to cause the infected cells to express viral proteins, the exogenous T cell antigen and inflammatory factors and stimulate a T cell immune response in the lymph nodes to the exogenous T cell antigen, wherein the live, modified, poxvirus expressing the antigen is administered to epithelial skin tissue that is disrupted to penetrate the stratum corneum without penetrating the entire epidermis.