Patent ID: 9499603
Filing Date: 2016-11-22
CPC Classification: A61P,C07K

Claim Text:
1. A humanised agonistic antibody which binds human PD-1comprising a heavy chain wherein the variable domain of the heavy chain comprises the sequence given in SEQ ID NO:1 for CDR-H1, the sequence given in SEQ ID NO:2 for CDR-H2 and the sequence given in SEQ ID NO:3 for CDR-H3; and the heavy chain framework region is derived from human sub-group sequence VH 1-3 1-46+JH4 (SEQ ID NO: 52), wherein a residue at at least one of positions 25, 37, 41, 48, 71, 73 and 76 of the variable domain of the heavy chain is a donor residue; or derived from human sub-group sequence VH 1-2 1-e +JH-4 (SEQ ID NO: 54) wherein the residue at, at least one of, positions 25, 37, 41, 48, 71, 76 and 78 of the variable domain of the heavy chain is a donor residue; and a light chain wherein the variable domain of the light chain comprises the sequence given in SEQ ID NO:4 for CDR-L1, the sequence given in SEQ ID NO:5 for CDR-L2 and the sequence given in SEQ ID NO:6 for CDR-L3; and the light chain framework region is derived from human sub-group sequence VK1 2-1(1) L23+JK4 (SEQ ID NO: 48), and the residue at, at least one of, positions 1, 2, 3, 4, 47, 60 and 70 of the variable domain of the light chain is a donor residue; or human sub-group sequence VK3 6-1(1) A27+JK4(SEQ ID NO: 50), and the residue at, at least one of, positions 2, 47, 58, 70, 71 and 85 of the variable domain of the light chain is a donor residue.