Patent ID: 9260509
Filing Date: 2016-02-16
CPC Classification: A61K,A61P,C07K,C12N

Claim Text:
1. A nucleic acid encoding a fusion protein comprising: (a) a Pseudomonas aeruginosa type A flagellin adjuvant or a Pseudomonas aeruginosa type B flagellin adjuvant; and (b) a Pseudomonas aeruginosa antigen, the antigen comprising a Pseudomonas aeruginosa OprF antigen and a Pseudomonas aeruginosa OprI antigen, wherein the Pseudomonas aeruginosa antigen is an N-terminal extension of the flagellin adjuvant, wherein the fusion protein is able to activate the TLR5 pathway, and wherein there is no significant difference in the half-maximal stimulation of TNF-α production between Pseudomonas aeruginosa type A flagellin, Pseudomonas aeruginosa type B flagellin, and the fusion protein.