Patent ID: 9290567
Filing Date: 2016-03-22
CPC Classification: A61K,A61P,C07K

Claim Text:
1. An antibody, which specifically binds to Tau phosphorylated at serine 442 (Tau pS422) and to the phosphorylated Tau fragment of SEQ ID NO:9 but does not bind to either wild-type Tau or to the phosphorylated human mitotic centromere-associated kinesin (MCAK) fragment of SEQ ID NO:17, and which comprises the complementary determining regions (CDRs): CDR1H of SEQ ID NO:55, CDR2H of SEQ ID NO:56, CDR3H of SEQ ID NO:57, CDR1L of SEQ ID NO:59, CDR2L of SEQ ID NO:60, and CDR3L of SEQ ID NO:61, wherein the antibody is a variant antibody that has been humanized.