Patent ID: 9518064
Filing Date: 2016-12-13
CPC Classification: A61K,A61P,C07D

Claim Text:
1. A compound of Formula I: or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate or prodrug thereof, wherein: W is O or S; R Y is S or —CR R R R provided that at least one of R 1a , R 8 and R 9 is other than H; R X X R R is phenyl or a 6-membered heteroaryl ring, at least one ring member of which is a nitrogen, which ring is substituted with 0 to 2 R a groups; B is selected from the group consisting of a C R R R alternatively, R 6 and R 7 , when attached to the same nitrogen, combine to form a 4- to 8-membered heterocyclic ring containing carbon atoms substituted by 0 to 3 groups independently selected from the group consisting of halo, CF 3 , CHF 2 , OCF 3 , OCHF 2 , OCH 2 F, 5- or 6-membered heteroaryl, OH, oxo, hydroxy-C 1 -C 4 -alkyl, C 1 -C 4 alkyl and C 1 -C 4 alkoxy, and 0 to 2 additional heteroatoms selected from N, NR 13 , O and S(O) p ; R R R n p, at each occurrence, is selected from 0, 1 and 2.