Patent ID: 9499579
Filing Date: 2016-11-22
CPC Classification: C07C,C07K

Claim Text:
1. A method of producing a peptide comprising: (1) removing an N-terminal protecting group from (i) an N-protected C-protected amino acid or (ii) a first N-protected C-protected peptide, wherein said N-protected C-protected amino acid and said first N-protected C-protected peptide have a C-terminus protected with an anchor which is a protecting group derived from a branched chain-containing aromatic compound, to obtain a C-protected amino acid or C-protected peptide; (2) condensing an N-protected amino acid or N-protected peptide with the N-terminus of said C-protected amino acid or C-protected peptide to obtain a second N-protected C-protected peptide; and (3) removing the N-terminal protecting group and the C-terminal anchor from said second N-protected C-protected peptide, to obtain said peptide, wherein said branched chain-containing aromatic compound is represented by formula (I): wherein each Q is independently a single bond, or —O—, —S—, —C(═O)O—, —C(═O)NH— or —NH—; each R k is an integer of 1 to 4; R ring A optionally further has, in addition to R X is a hydrogen atom or a phenyl group; Y is a hydroxyl group, an —NHR group (wherein R is a hydrogen atom, an alkyl group, or an aralkyl group), or a halogen atom; and Z is a hydrogen atom or a group represented by formula (a): wherein * indicates the bonding position; m is an integer of 0 to 4; each Q is as defined above; each R R ring B optionally further has, in addition to (QR wherein said organic group having at least one aliphatic hydrocarbon group having one or more branched chains, a total number of the branched chain of not less than 3 and a total carbon number of not less than 14 and not more than 300 for each R wherein * indicates the bonding position with the adjacent atom; R X provided that R