Patent ID: 9523778
Filing Date: 2016-12-20
CPC Classification: C07B,G01T,G16B

Claim Text:
1. A method of performing radiosynthesis with an automated radiosynthesizer, the radiosynthesizer having a plurality of individual activity detectors operably associated therewith, comprising the steps of: Providing a calibration standard comprising a source of gamma radiation having both a known activity and a known time decay correlation factor in the vicinity of each activity detector of the radiosynthesizer at defined time intervals; Measuring activity data with each activity detector as said calibration standard is in the vicinity thereof; Determining the correlation factor C where x is the known activity of said calibration standard, y is the activity data measured at the each individual activity detector, and z is a defined decay by time decay correlation factor for said calibration standard; Normalizing each individual activity detector prior to the radiosynthesis; and Synthesizing a tracer with the radiosynthesizer, wherein the synthesizing step further comprises the step of: detecting activity readings by each individual activity detector as the tracer is synthesized, and monitoring the radiosynthesis by applying the correlation factor C