Patent ID: 9416167
Filing Date: 2016-08-16
CPC Classification: A61K,A61P,C07K

Claim Text:
1. A stable pharmaceutical formulation comprising: (a) 50-100 mg/mL of a vascular endothelial growth factor (VEGF) antagonist fusion protein dimer consisting of two identical fusion polypeptides consisting essentially of (i) the immunoglobulin-like domain 2 of the human Flt1 VEGF receptor, (ii) the immunoglobulin-like domain 3 of the human Flk1 or the human Flt4 VEGF receptor, and (iii) an immunoglobulin Fc domain; (b) 5-50 mM histidine; (c) 0.1-3.0% polyethylene glycol (PEG) 3350; (d) 0.24-3.0% glycine; and (e) 0.5-6.0% sucrose, pH 6.3-6.5.