Patent ID: 9339523
Filing Date: 2016-05-17
CPC Classification: A61K,A61P

Claim Text:
1. A composition that modulates the expression of a gene under control of an estrogen response element, wherein the composition consists of: (a) at least one member of the group consisting of pharmaceutically acceptable solvents, diluents, flavorings, and sweeteners; (b) an extract obtained from a plant or a part thereof, wherein the plant is a member of the taxonomic species Asparagus cochinchinensis (Lour.) Merr of the Liliaceae family, the extract includes one or more compounds dissolved in a solvent selected from the group consisting of: ethyl acetate, acetonitrile, hexanes, alcohol, methanol, ethanol, i-propanol, n-propanol, n-butanol, t-butanol, s-butanol, i-butanol, chloroform, acetone, cyclohexane, cycloheptane, and petroleum ether, wherein the one or more compounds are capable of binding at least one of estrogen receptors ERα and ERβ in cells growing in vitro or in vivo; and (c) and at least one active pharmaceutical ingredient that exhibits synergistic activity in combination with the extract and selectively modulates estrogen receptors, the at least one active pharmaceutical ingredient comprising raloxifene or tamoxifen.