Patent ID: 9347090
Filing Date: 2016-05-24
CPC Classification: C12Q,G01N

Claim Text:
1. A method comprising the follow steps: (i) obtaining a biological sample from a patient who does not have severe periodontal disease; (ii) isolating a nucleic acid sample from said biological sample; (iii) contacting said nucleic acid sample with oligonucleotide primers that hybridize 5′ and 3′ to each of the following single nucleotide polymorphisms (SNPs) in the IL1B gene: rs16944 C/T; rs1143623 G/C; and rs4848306 C/T; (iv) amplifying nucleic acid in said nucleic acid sample with said oligonucleotide primers to produce one or more amplified fragments, wherein each of said SNPs is included in at least one of said one or more amplified fragments; (v) detecting the number of copies of allele 1 and allele 2 of each of said SNPs in said one or more amplified fragments, wherein as a result of said detecting, the presence of one of the following composite genotypes is detected in said patient: (vi) treating the patient of step (v), in whom one of the composite genotypes a)-e) has been detected, with a treatment regimen to slow down the progression of periodontal disease.