Patent ID: 9512174
Filing Date: 2016-12-06
CPC Classification: A61K,C07C,C07D,C07F,C07K,G01N

Claim Text:
1. A method of synthesizing a fluorescent functionalized naphthalene comprising: reacting a 2′-alkynyl substituted halostyrene by a dehydrogenative intramolecular dehydro Diels Alder reaction in the presence of microwave irradiation to form a halo substituted naphthalene; and reacting the halo substituted naphthalene to a cross coupling reaction to form a functionalized naphthalene having a structure where R 1 is a substituent selected from the group consisting of H, C 1 -C 20 alkyl, C 1 -C 20 alkoxy, phenyl, aryl, heteroaryl, —S(O)R 4 , —S(O) 2 R 4 , P(O)(OR 4 ) 2 , and —C(Y)R 4 where Y is O, NR 5 , or S; each R 2 is a halogen or an electron donating group selected from —N(R 6 ) 2 , —OR 6 , and —SR 6 ; each R 3 is H, C 1 -C 20 alkyl, or combined as ═O; each R 4 , R 5 and R 6 is independently selected from H, C 1 -C 20 alkyl, C 1 -C 20 alkoxy, substituted or unsubstituted phenyl, aryl, heteroaryl, benzyl, or may come together to form a cyclic structure; X is CH 2 , C(R 6 ) 2 , C(CO 2 Alkyl) 2 , O, NTs, NH, NCOR 5 or NR 5 ; n is an integer from 0 to 2; m is an integer from 1 to 4, provided that either R