Patent ID: 9516868
Filing Date: 2016-12-13
CPC Classification: A01K,C07K,C12N

Claim Text:
1. A mouse whose germline genome comprises a modified endogenous mouse immunoglobulin heavy chain locus comprising a replacement of all functional endogenous mouse immunoglobulin heavy chain variable (V H ) gene segments, all functional endogenous mouse immunoglobulin heavy chain diversity (D H ) gene segments and all functional endogenous mouse immunoglobulin heavy chain joining (J H ) gene segments at the endogenous mouse immunoglobulin heavy chain locus with a nucleotide sequence that comprises a plurality of contiguous unrearranged functional human immunoglobulin light chain variable V κ (hV κ ) gene segments and all five unrearranged functional human immunoglobulin light chain joining gene segments (hJ κ 1-hJ κ 5), wherein the plurality of unrearranged functional hV wherein the plurality of unrearranged functional hV wherein the mouse comprises a CD19