Patent ID: 9528113
Filing Date: 2016-12-27
CPC Classification: C07K,C12N,C12Q

Claim Text:
1. A method of non-invasively monitoring in vivo the expression of a gene of interest in a cell, comprising: a) introducing a nucleic acid molecule comprising: b) detecting the fluorescent reporter polypeptide in said cell by a non-invasive optical imaging method; c) contacting said cell with a demethylating drug; d) detecting the fluorescent reporter polypeptide in said cell by a non-invasive optical imaging method upon step c); e) comparing the level of fluorescent reporter polypeptide detected in step b) to the level of fluorescent reporter polypeptide detected in step d); f) assigning the change in the expression of said gene of interest induced by said demethylating drug based on the comparison in step e).