Patent ID: 9376494
Filing Date: 2016-06-28
CPC Classification: A61K,A61P,C07H,C07K,C12N

Claim Text:
1. An isolated monoclonal antibody or antigen binding fragment thereof that specifically binds to Kallidin or des-Arg 10 -Kallidin but not to Bradykinin or des-Arg 9 -Bradykinin, wherein the antibody or antigen binding fragment comprises: i) a heavy chain variable domain comprising a heavy chain complementarity determining region 3 (HCDR3) amino acid sequence selected from the group consisting of: a) SEQ ID NO: 7 [X b) SEQ ID NO: 63 [X c) SEQ ID NO: 13; d) SEQ ID NO: 32; e) SEQ ID NO: 40; f) SEQ ID NO: 47; and g) SEQ ID NO: 55; ii) a heavy chain variable domain comprising a heavy chain complementarity determining region 2 (HCDR2) amino acid sequence selected from the group consisting of: h) SEQ ID NO: 8 [YFX i) SEQ ID NO: 64 [WX j) SEQ ID NO: 14 k) SEQ ID NO: 33; l) SEQ ID NO: 41; m) SEQ ID NO: 48; and n) SEQ ID NO: 56; iii) a heavy chain variable domain comprising a heavy chain complementarity determining region 1 (HCDR1) amino acid sequence selected from the group consisting of: o) SEQ ID NO: 9 [GYSFTDYX p) SEQ ID NO: 65 [GFNIKDYYX q) SEQ ID NO: 15; r) SEQ ID NO: 34; s) SEQ ID NO: 42; t) SEQ ID NO: 49; and u) SEQ ID NO: 57; iv) a light chain variable domain comprising a light chain complementarity determining region 3 (LCDR3) amino acid sequence selected from the group consisting of: v) SEQ ID NO: 10 [QQ X w) SEQ ID NO: 66 [QX x) SEQ ID NO: 69 [X z) SEQ ID NO: 16; aa) SEQ ID NO: 35; bb) SEQ ID NO: 43; cc) SEQ ID NO: 50; and dd) SEQ ID NO: 58; v) a light chain variable domain comprising a light chain complementarity determining region 2 (LCDR21 amino acid sequence selected from the group consisting of: ee) SEQ ID NO: 11 [WASTRX ff) SEQ ID NO: 67 [X gg) SEQ ID NO: 17; hh) SEQ ID NO: 36; ii) SEQ ID NO: 51; and jj) SEQ ID NO: 59; and vi) a light chain variable domain comprising a light chain complementarity determining region 1 (LCDR11 amino acid sequence selected from the group consisting of: kk) SEQ ID NO: 12 [KSSQSLL X ll) SEQ ID NO: 68 [KSSQSLLX mm) SEQ ID NO: 70 [KSSQSLLYSNGX1TYLN], wherein X1 is K or E; nn) SEQ ID NO: 18; oo) SEQ ID NO: 37; pp) SEQ ID NO: 44; qq) SEQ ID NO: 52; and rr) SEQ ID NO: 60.