Patent ID: 9334219
Filing Date: 2016-05-10
CPC Classification: C07B,C07C

Claim Text:
1. A process for the preparation of a stable polymorph III of Atovaquone which comprises: a) providing a sample of Atovaquone particles; b) heating the sample of Atovaquone particles of step (a) at a temperature of at least about 160° C. for a time sufficient of at least about one hour to obtain a stable polymorphic form of Atovaquone, having characteristic peaks (expressed in degrees 2θ±0.2° θ) at approximately one or more of the positions: about 6.9, 9.6, 14.1, 14.7, 17.0, 18.5, 19.1, 19.9, 20.3, 22.0, 22.6, 23.2, 24.2, 26.8, and 28.5; and c) cooling the sample of step (b); wherein the process is carried out in the absence of a solvent.