Patent ID: 9446115
Filing Date: 2016-09-20
CPC Classification: A61K,A61P,C07K,C12N,Y02A

Claim Text:
1. A method of stimulating an immune response in a subject, comprising the step of administering to the subject a composition that includes a fusion protein comprising a portion of at least one flagellin and at least a portion of at least one Dengue viral envelope protein selected from the group consisting of a Den1 viral envelope protein, a Den2 viral envelope protein, a Den3 viral envelope protein and a Den4 viral envelope protein, wherein the portion of the flagellin is a Toll-like Receptor 5 agonist, the portion of the Dengue viral envelope protein is an antigen, and wherein the fusion protein activates Toll-like Receptor 5 and induces antibodies that neutralize a Dengue virus.