Patent ID: 9284559
Filing Date: 2016-03-15
CPC Classification: A61K,A61P,C12N,Y02A

Claim Text:
1. A method of introducing a nucleic acid of interest into a cell of interest, comprising contacting a composition to said cell under conditions in which said nucleic acid of interest is internalized into said cell; said composition comprising a pair of compounds, at least one member of said pair of compounds comprising said nucleic acid of interest, and each member of said pair having a second nucleic acid that is complementary to and hybridized to the second nucleic acid of the other member of said pair; each of said compounds independently having the formula A-B-C, wherein: A is a first nucleic acid that specifically binds to an extracellular surface protein expressed by a cell of interest, B is an alkyl linker; and C is said second nucleic acid; wherein said first and/or second nucleic acid of at least one of said compounds comprises poly-FdUMP; and wherein said second nucleic acid of each of said compounds is DNA.