Patent ID: 9295696
Filing Date: 2016-03-29
CPC Classification: A61K,C12N

Claim Text:
1. A method of restoring or rejuvenating function of adult muscle-derived stem/progenitor cells (MDSPCs) having cell proliferation and/or differentiation defects, comprising: exposing said adult MDSPCs to an exogenous amount of isolated young allogeneic MDSPCs and an inhibitor of mTOR and/or of IKK/NF-κB pathway, wherein said isolated allogeneic MDSPCs secrete or release one or more regulatory factors comprising RBP-JK inhibitory factor, Stanniocalcin-1, Wnt3a, KLOTHO, CCL11, miRNA-489, VEGF, HGF, IGF, and Her-2/neu (ERBB2/c-erbB-2); wherein said one or more secreted or released regulatory factors restore or rejuvenate said adult MDSPCs function.