Patent ID: 9526702
Filing Date: 2016-12-27
CPC Classification: A61K,A61P,Y02A

Claim Text:
1. Nanoparticles having a geometric diameter of between greater than 60 nm and less than 250 nm, and formed of one or more polymers selected from the group consisting of polyesters, polyhydroxacids, poly(orthoesters); polyanhydrides, polyalkylene oxides, and copolymers thereof, wherein the nanoparticles selectively target the subcapsular macrophages and dendritic cells in the draining lymph nodes, and wherein the nanoparticles comprise a dendritic cell immunomodulatory agent selected from the group consisting of toll-like receptor agonists, CD40 agonists, and agents which promote dendritic cell maturation; and a T cell peptide antigen for processing by dendritic cells and presentation with major histocompatibility complex (MHC) to T cells.