Patent ID: 9493838
Filing Date: 2016-11-15
CPC Classification: A61P,C12N,C12Q

Claim Text:
1. A method for predicting a response to a cardiac therapy in a patient suffering from a cardiac disease, comprising: i) reverse transcribing one or more biomarkers having at least 85% sequence identity to one or more sequences of SEQ ID NOs: 1, 27, and/or 33 to one or more DNA products by contacting a sample from the patient comprising the one or more biomarkers having at least 85% sequence identity to one or more sequences of SEQ ID NOs: 1, 27, and/or 33 with at least one primer having a sequence that is complementary to one or more sequences of SEQ ID NOs: 1, 27, and/or 33; ii) amplifying the one or more DNA products from i) by quantitative polymerase chain reaction (qPCR) to detect the level of expression of the one or more biomarkers in the patient sample; and iii) comparing the level of expression of the one or more biomarkers in the patient sample to a control sample to predict the response to the cardiac therapy in the patient, wherein an increase in the level of expression of the one or more biomarkers in the patient sample relative to the control sample is a prediction of a positive response to the cardiac therapy in the patient.