Patent ID: 9267937
Filing Date: 2016-02-23
CPC Classification: A61K,B82Y,C40B,G01N

Claim Text:
1. A high throughput, iterative, combinatorial screening method of identifying targeting agents or particle properties providing enhanced uptake of particles into targeted cells in tissue, the method comprising the steps of providing a plurality of synthetic polymeric particle populations, wherein the particles of each population have substantially the same composition, size, density, surface chemistry, targeting agent or density of targeting agent bound thereto, wherein the particles of a given particle population differ from the particles of another given particle population by at least one particle characteristic, and wherein each particle of a given population has at least one detectable label which is different from the detectable label of the particles of another given particle population and is different from the targeting agent; administering the plurality of particle populations to an animal under conditions in which the particles are taken up by cells of a targeted tissue; and enriching the uptaken particles by repeating the process with different populations of particles, each population having at least one different particle characteristic, thereby determining the particle characteristics which enhance uptake of the particles by the cells of the targeted tissue.