Patent ID: 9269144
Filing Date: 2016-02-23
CPC Classification: A61B,G06T

Claim Text:
1. A computer-implemented method of correcting a data set representing an object for the object's motion relative to an optical coherence tomography (OCT) imaging instrument, comprising: acquiring at least a first three-dimensional data set and a second three-dimensional data set representing overlapping regions of an object with the OCT imaging instrument, wherein the first three-dimensional data set and the second three-dimensional data set are obtained in an instrument coordinate system; optionally, computing at least one of a first derivative three-dimensional data set corresponding to the first three-dimensional data set, a second derivative three-dimensional data set corresponding to the second three-dimensional data set, a first preprocessed three-dimensional data set corresponding to the first three-dimensional dataset, or a second preprocessed three-dimensional data set corresponding to the second three-dimensional dataset; determining sample positions in an object coordinate system; for at least the first and the second three-dimensional data sets, computing a first three-dimensional transform and a second three-dimensional transform respectively, wherein every transform associates a three-dimensional displacement vector with each sample position in the object coordinate system, and wherein computing the first and the second three-dimensional transforms includes: a. for each of the first and the second three-dimensional transform, computing a first three-dimensional displacement vector for each sample position in the object coordinate system; b. for each of the first and the second three-dimensional transform, computing, based on the first three-dimensional displacement vectors, positions in the instrument coordinate system; c. for each of the first and the second three-dimensional transform, interpolating data of the respective three-dimensional data set or preprocessed three-dimensional data set at the positions in the instrument coordinate system, thereby producing a first set of interpolated values and a second set of interpolated values; d. evaluating an objective function by calculating similarity between the first and the second sets of interpolated values and estimating motion of the object relative to the OCT imaging instrument; and e. based on the value of the objective function, for each of the first and the second three-dimensional transform, computing a second three-dimensional displacement vector for each sample position in the object coordinate system; and applying at least one three-dimensional transform to at least one of the first or the second three-dimensional data sets, or the first or the second derivative three-dimensional data sets to obtain at least one motion-corrected data set representing the object.