Patent ID: 9346821
Filing Date: 2016-05-24
CPC Classification: A61K,A61P,C07D

Claim Text:
1. A compound represented by formula (I), or a pharmaceutically acceptable salt thereof: wherein D is a benzene ring, a naphthalene ring or a pyridine ring; Het is a hetero ring represented by formula (III-1) wherein Z1 and Z2 may be the same or different and is each independently CRa and Z3 is an oxygen atom, wherein Ra is independently a hydrogen atom, a nitro group, a halogen atom, a cyano group, a hydroxyl group, a thiol group, an amino group, a guanidino group, a formyl group, a lower alkyl group, a lower alkenyl group, a lower alkynyl group, a lower acyl group, a carboxyl group, a sulfo group, a phosphono group, a lower alkoxyl group, a lower alkylthio group, a lower alkylamino group, a lower acyloxy group, a lower acylamino group, a lower alkoxycarbonyl group, a carbamoyl group, a lower alkylcarbamoyl group, a lower alkylsulfonylamino group or a sulfamoyl group; R1 is a hydrogen atom, a nitro group, a halogen atom, a cyano group, a hydroxyl group, a thiol group, an amino group, a guanidino group, a formyl group, a lower alkyl group, a lower alkenyl group, a lower alkynyl group, a lower acyl group, a carboxyl group, a sulfo group, a phosphono group, a lower alkoxyl group, a lower alkylthio group, a lower alkylamino group, a lower acyloxy group, a lower acylamino group, a lower alkoxycarbonyl group, a carbamoyl group, a lower alkylcarbamoyl group, a lower alkylsulfonylamino group, or a sulfamoyl group; n is an integer of 0 to 3; each R2 is independently a nitro group, a halogen atom, a cyano group, a hydroxyl group, a thiol group, an amino group, a guanidino group, a formyl group, a lower alkyl group, a lower alkenyl group, a lower alkynyl group, a lower acyl group, a carboxyl group, a sulfo group, a phosphono group, a lower alkoxyl group, a lower alkylthio group, a lower alkylamino group, a lower acyloxy group, a lower acylamino group, a lower alkoxycarbonyl group, a carbamoyl group, a lower alkylcarbamoyl group, a lower alkylsulfonylamino group, or a sulfamoyl group; X is a lower alkylene group optionally having one or more substituents selected from the group consisting of a halogen atom, a hydroxyl group, an amino group, a lower alkoxyl group, a lower acyl group, and an oxo group, provided when said lower alkylene group has one or more substituents and A is CO Z is —N(R3)- wherein R3 is a hydrogen atom, a lower alkyl group optionally having substituent(s) selected from the group consisting of a a carboxyl group and —CONH—CH Y is a single bond or —(CH A is —CO wherein R5 is a hydrogen atom, a lower alkyl group optionally having substituent(s) selected from the group consisting of a nitro group, a halogen atom, a cyano group, a hydroxyl group, a thiol group, an amino group, a guanidino group, a formyl group, a phenyl group, a lower alkyl group, a lower alkenyl group, a lower alkynyl group, a lower acyl group, a carboxyl group, a sulfo group, a phosphono group, a lower alkoxyl group, a lower alkylthio group, a lower alkylamino group, a lower alkoxycarbonyl group, a carbamoyl group, a lower alkylcarbamoyl group, a lower alkylsulfonylamino group, a sulfamoyl group, and —CONH—CH Q is a lower alkylene group optionally having one or more substituents selected from the group consisting of a nitro group, a halogen atom, a cyano group, a hydroxyl group, a thiol group, an amino group, a guanidino group, a formyl group, a lower acyl group, a carboxyl group, a sulfo group, a phosphono group, a lower alkoxyl group, a lower alkylthio group, a lower alkylamino group, a lower acyloxy group, a lower acylamino group, a lower alkoxycarbonyl group, a carbamoyl group, a lower alkylcarbamoyl group, a lower alkylsulfonylamino group, an arylsulfonylamino group optionally having substituent(s) selected from the group consisting of a nitro group, a halogen atom, a cyano group, a hydroxyl group, a thiol group, an amino group, a guanidino group, a formyl group, a lower alkyl group, a lower alkenyl group, a lower alkynyl group, a lower acyl group, a carboxyl group, a sulfo group, a phosphono group, a lower alkoxyl group, a lower alkylthio group, a lower alkylamino group, a lower alkoxycarbonyl group, a carbamoyl group, a lower alkylcarbamoyl group, a lower alkylsulfonylamino group, a sulfamoyl group, and —CONH—CH R7 is a hydrogen atom, or R2 and R3 are optionally bonded together to form tetrahydropyridine; R3 and R4a are optionally bonded together to form a hetero ring selected from the group consisting of pyrrolidine, piperidine, thiazolidine, and tetrahydroisoquinoline; R3 and R4a and R4b are optionally bonded together to form pyrrole; and R4a and R4b are optionally bonded together to form lower cycloalkane.