Patent ID: 9481911
Filing Date: 2016-11-01
CPC Classification: A61K,A61P,C07K,C12Q,G01N

Claim Text:
1. A method for detecting a fusion gene consisting of a portion of a fibroblast growth factor receptor 3 (FGFR3) gene and a portion of a transforming acidic coiled-coil containing protein 3 (TACC3) gene in a sample obtained from a test subject, comprising: (a) detecting in said sample a polynucleotide encoding a polypeptide that has tumorigenicity and comprises an amino acid sequence having 90% or greater identity to the amino acid sequence represented by amino acid numbers 461 to 947 of SEQ ID NO: 2, amino acid numbers 461 to 982 of SEQ ID NO: 4, amino acid numbers 461 to 996 of SEQ ID NO: 6, amino acid numbers 461 to 1043 of SEQ ID NO: 26, or amino acid numbers 461 to 1040 of SEQ ID NO: 28, wherein detecting the polynucleotide comprises nucleic acid amplification, nucleic acid hybridization, or fluorescence in situ hybridization; or (b) detecting in said sample the polypeptide encoded thereof by an immunoassay, an enzymatic assay, or a proximity ligation assay.