Patent ID: 9523671
Filing Date: 2016-12-20
CPC Classification: A61K,C12Q,G01N

Claim Text:
1. A method for predicting and/or quantifying the response of a subject to prebiotics in the prevention of diet induced weight gain, comprising: a) determining a level of indoxyl sulfate in a urine sample obtained from a subject that has consumed prebiotics using b) comparing the subject's indoxyl sulfate level to a predetermined reference value by mapping or graphing the urinary excretion of indoxyl sulfate, wherein a decreased indoxyl sulfate level, or an absence of change in the indoxyl sulfate level, in the urine sample compared to the predetermined reference value indicates that the administration of prebiotics is effective in the prevention of diet induced weight gain in the subject, and wherein the predetermined reference value is based on an average indoxyl sulfate level in a control population of subjects consuming a high fat diet and the change of indoxyl sulfate level is determined relative to a cut-off value.