Patent ID: 9434737
Filing Date: 2016-09-06
CPC Classification: C07B,C07C,C07D,C12P

Claim Text:
1. A process for producing compound A, or a salt thereof, said process comprises: (A) reacting an ester derivative represented by formula (IV):  or a salt thereof, (B) reacting said optically active carboxylic acid derivative represented by formula (V) or said salt thereof with (i) an ammonia source in the presence of a condensing agent, or (ii) an activating reagent to produce a resultant intermediate, and reacting said resultant intermediate with an ammonia source for conversion of said intermediate into an optically active amide derivative represented by formula (VI):  or a salt thereof, (C1) when R  or a salt thereof, (C2) when R  or a salt thereof, (D) reacting said optically active succinimide derivative of formula (I) with 2,5-dimethoxytetrahydrofuran with an acid to produce a first product; (E) reacting said first product of step (D) with a trichloroacetylating reagent to produce a second product; (F) reacting said second product of step (E) with 4-bromo-2-fluorobenzylamine to produce said compound A or said salt thereof; and (G) isolating said compound A or said salt thereof.