Patent ID: 9248107
Filing Date: 2016-02-02
CPC Classification: A01N,A61K,A61P,C12N,Y02A

Claim Text:
1. A formulation capable of enhancing thermostability and shelf-life of a biological product, the formulation comprising: trimethylamine-N-oxide, mannitol, glutamic acid, magnesium chloride, (MgCl 2 ), a physiologically acceptable buffer, a pharmaceutically acceptable carrier, and optionally, sodium chloride; wherein the concentration of trimethylamine-N-oxide is from about 1.5 millimolar to about 800 millimolar; the concentration of magnesium chloride is from about 0.8 millimolar to about 80 millimolar; the concentration of glutamic acid is from about 5 millimolar to about 500 millimolar; the concentration of mannitol, (C 6 H 8 (OH) 6 ), is from about 0.01 percent (w/v) to about 5 percent (w/v); wherein when sodium chloride is present, the concentration of sodium chloride is from about 100 millimolar to about 500 millimolar; wherein the biological product is a vaccine comprising an inactivated or an attenuated Yellow Fever virus.