Patent ID: 9381292
Filing Date: 2016-07-05
CPC Classification: A61K,A61M,C12N

Claim Text:
1. A device for producing a supply of insulin and glucagon, implanted on or in a human in need of treatment for type 1 diabetes, comprising: (a) a blood separator component comprising a blood inlet to receive incoming blood from a bloodstream of the human, a microfluidic chip to maintain a density gradient for a blood flow inside the blood separator, the microfluidic chip comprising a main channel with a microsieve to separate the blood flow into a leukocyte-rich blood fraction and a leukocyte-depleted blood fraction and to divide the main channel into first and second bifurcated channels, the microsieve comprising a plurality of round pores of 5-20 micron in diameter length, wherein the leukocyte-depleted blood fraction is transported by the first bifurcated channel into an islet compartment and the leukocyte-rich blood fraction is transported by the second bifurcated channel into an exiting channel and through a blood outlet to return to the bloodstream; (b) an islet compartment comprising multiple beta and alpha cells from at least one compatible donor pancreas; wherein the beta and alpha cells are encapsulated within a semi-permeable, biocompatible protecting coating, wherein the blood glucose level in the leukocyte-depleted blood is continuously monitored by the beta and alpha cells in real time, wherein the beta cells produce an elevated level of insulin during hyperglycemia and the alpha cells produce an elevated level of glucagon during hypoglycemia; and (c) an exiting channel comprising a blood outlet to transport the leukocyte-depleted blood fraction, insulin and/or glucagon secreted by the beta and/or alpha cells of the islet compartment and leukocyte-rich blood fraction out of the device back into the blood stream of the human.