Patent ID: 9359385
Filing Date: 2016-06-07
CPC Classification: C07C,C07D,C07F

Claim Text:
1. A process for the preparation of an intermediate of formula I, wherein the stereogenic center marked with an * is either in (R)- or (S)-configuration at marked center, or it is in racemic form, and wherein R (i) hydrogen; (ii) alkyl residues optionally chiral, having from 1 to 12 carbon atoms, wherein the alkyl residues are optionally aryl and/or aryloxy substituted; (iii) alkyloxy residues optionally chiral, having from 1 to 12 carbon atoms, wherein the alkyloxy residues are optionally aryl substituted; (iv) aryl residues optionally chiral, having from 6 to 24 carbon atoms, wherein the aryl residues are optionally alkyl and/or alkyloxy substituted; (v) aryloxy residues optionally chiral, having from 6 to 24 carbon atoms, wherein the aryloxy residues are optionally alkyl substituted; (vi) benzyl; (vii) alkaloyl residues optionally chiral, having from 2 to 13 carbon atoms, wherein the alkaloyl residues are optionally aryl substituted; (viii) aroyl residues optionally chiral, having from 7 to 25 carbon atoms, wherein the aryloxy residues are optionally alkyl substituted; (ix) alkoxycarbonyl residues optionally chiral, having from 2 to 13 carbon atoms; (x) aryloxycarbonyl residues optionally chiral, having from 7 to 25 carbon atoms; (xi) tosyl; (xii) silyl residues optionally chiral, having from 3 to 15 carbon atoms; and (xiii) silyloxy residues optionally chiral, having from 3 to 15 carbon atoms; wherein R the process comprising the steps of: (a) providing an intermediate of formula II, (b) reacting the intermediate of formula II with an amine of formula Ill, wherein R wherein the catalyst is selected from Brønsted acids, amino acids, thioureas, and Cinchona alkaloids, and the promoter is selected from fluorinated alcohols and surfactants, to obtain an intermediate of formula I.