Patent ID: 9289473
Filing Date: 2016-03-22
CPC Classification: A61K,A61P,C12N,C12Y

Claim Text:
1. A polypeptide comprising an amino acid sequence at least 85% identical to the amino acid sequence of SEQ ID NO:35 residues 1-378, wherein (a) the polypeptide degrades a PQPQLP (SEQ ID NO:34) peptide at pH 4; (b) residue 278 is Ser, residue 78 is Glu, and residue 82 is Asp; and (c) the polypeptide comprises an amino acid change from SEQ ID NO: 67 residues 1-378 at one or more residues selected from the group consisting of amino acid residues 73, 102, 103, 104, 130, 165, 168, 169, 172, and 179, wherein if the amino acid change is at residue 73, the residue 73 amino acid is changed to either K or G.