Patent ID: 9255070
Filing Date: 2016-02-09
CPC Classification: C07B,C07C,C07D

Claim Text:
1. A method for deuteration of a compound having a substituted benzene ring, comprising reacting the compound having the substituted benzene ring with a heavy hydrogen source in the presence of an activated mixed catalyst consisting of a palladium catalyst and a platinum catalyst under sealed reflux condition, wherein the compound comprises at least one substituent bound to a benzene ring in the compound, and the substituent comprises at least one carbon atom and at least one hydrogen atom, the at least one hydrogen atom being bound to the at least one carbon atom in the substituent, and wherein all hydrogen atoms that are bound to carbon atoms and are located in both the at least one substituent and the benzene ring of the compound are deuterated at a weight average deuteration ratio in a range of 74.5% or higher.