Patent ID: 9522190
Filing Date: 2016-12-20
CPC Classification: A61K

Claim Text:
1. A method for storing a pharmaceutical composition in a stable condition for 6 months or more in an aqueous solution form for use as final product, comprising: storing the pharmaceutical composition comprising a polymeric drug carrier, a bioactive agent entrapped inside the drug carrier, an aqueous solvent, a pH adjusting agent, and an isotonic agent under refrigeration at 0 to 10° C., wherein the polymeric drug carrier comprises (a) an non-ionic amphiphilic block copolymer containing a hydrophilic block and a hydrophobic block, and (b) a polylactic acid derivative including a di- or tri-valent metal ion substituted for a monovalent metal ion which is bound to the terminal carboxyl group of a D,L-polylactic acid, wherein the polymeric drug carrier is prepared without lyophilization, wherein the hydrophilic block is selected from the group consisting of monomethoxypolyethylene glycol and polyethylene glycol, and the hydrophobic block is polylactide; and wherein the bioactive agent is selected from the group consisting of paclitaxel, docetaxel, sirolimus, temsirolimus, and everolimus.