Patent ID: 9445975
Filing Date: 2016-09-20
CPC Classification: A61K,A61Q,B82Y

Claim Text:
1. A method for preparing a stable translucent to transparent unilamellar liposomal suspension comprising: a. preparing an oil-soluble composition comprising b. preparing a water-soluble composition; c. combining with agitation the water-soluble composition and the oil-soluble composition to form a multilamellar and multivesicular liposome preparation, wherein the water soluble composition is present in an amount from about 67% to about 95% by weight of the liposome preparation and the oil soluble composition is present in an amount from about 5% to about 33% by weight of the liposome preparation; d. converting the multilamellar and multivesicular liposome preparation to a unilamellar liposome preparation by one of high pressure microfluidization, extrusion, high speed shearing, milling, sonication, selective microchannel filtration or homogenization, wherein the unilamellar liposome preparation comprises a plurality of unilamellar liposomal particles having a unimodal size distribution with a mean particle size between about 50 to about 290 nm; and e. adding the unilamellar liposome preparation to an external phase composition that includes a viscosity promoting agent selected from thickening agents to provide the unilamellar liposomal suspension, wherein the external phase composition has a density within a range of about 1.05 g/cc to about 1.25 g/cc and a viscosity between about 2.5 cP and about 40,000 cP at a shear rate of 10 sec wherein the liposomal suspension is translucent to transparent, has a refractive index between 1.30 and 1.45 and retains its stability in neat form at temperatures between about 4° C. to about 50° C. for a period of at least 30 days, or at 21° C. for a period of at least 180 days.