Patent ID: 9260479
Filing Date: 2016-02-16
CPC Classification: C07D,C07F,C07K

Claim Text:
1. A process to produce a cyclic molecule comprising reacting an amino acid molecule, having an amino terminus and a carboxyl terminus, with an isocyanide and a compound having formula (Ia) and/or (Ib): wherein: R the aldehyde component thereof may optionally be in its bisulfite adduct form; and the amino acid molecule is an amino acid, a linear peptide or a salt of the foregoing, provided that if the amino acid molecule is a linear peptide, the compound having formula (Ia) and/or (Ib) comprises an aziridine chiral center proximal to the aldehyde with matching stereochemistry to the carbon atom proximal to the amino terminus of the peptide; wherein the cyclic molecule is of formula (II): wherein Z is an amino terminus of an amino acid; —C═O—C is the carboxy terminus of an amino acid; L, along with Z and —C═O— is an amino acid or peptide; and R″ is an optionally substituted amide.