Patent ID: 9527927
Filing Date: 2016-12-27
CPC Classification: C07K

Claim Text:
1. A bispecific antibody comprising: (a) an Fc region comprising a modified heavy chain, wherein the CH1 region of the modified heavy chain comprises (b) a modified corresponding light chain, wherein the CL region of the modified light chain comprises (c) a second Fc region comprising a second heavy chain; and (d) a second corresponding light chain, wherein the modified heavy chain is directly linked to the corresponding modified light chain, and on a separate target binding arm, the second heavy chain is directly linked to the second corresponding light chain, and wherein the substituted cysteine of the modified heavy chain, resulting from the substitution of the native non-cysteine amino acid to the cysteine amino acid, and the substituted cysteine of the modified corresponding light chain, resulting from the substitution of the native non-cysteine amino acid to the cysteine amino acid, can form a disulphide bond, wherein the substitutions in the modified heavy chain and modified corresponding light chain are selected from the group consisting of variants V10, V10-2a, V10-2b, V10-3, V10-4, V11, V11-2a, V11-2b, V11-3, V11-4, V12, V12-2a, V12-2b, V12-3 and V12- 4 as provided in Table 4.