Patent ID: 9345785
Filing Date: 2016-05-24
CPC Classification: A61K,A61P,C07K

Claim Text:
1. A method for the treatment of a CD70-expressing renal cell carcinoma in a human subject, the method comprising: administering to the subject, in an amount effective for the treatment thereof, an antibody-drug conjugate comprising an antibody that specifically binds to CD70, wherein the antibody is a mouse antibody comprising a heavy chain variable region having the amino acid sequence set forth in residues 20 to 137 of SEQ ID NO:2, and a light chain variable region having the amino acid sequence set forth in residues 21 to 132 of SEQ ID NO:12, or a chimeric or humanized form of the mouse antibody, and wherein: (i) the drug is a cytotoxic agent that is a DNA minor groove binding agent, an alkylating agent, or an anti-tubulin agent, and (ii) the antibody-drug conjugate is internalized into cells, where it exerts a cytotoxic effect.