Patent ID: 9364570
Filing Date: 2016-06-14
CPC Classification: A61K,C07D

Claim Text:
1. A method of attaching a moiety capable of binding to a biological entity to an amino substituted metal chelating ligand or a metal complex thereof the method comprising: (a) reacting an amino substituted metal chelating ligand or a metal complex thereof with a molecule of the formula (1): wherein L is a bond or a linking moiety and R is H or a moiety capable of binding to a biological entity or a protected form thereof or a synthon thereof; (b) isolating the compound or a metal complex thereof thus produced wherein the amino substituted metal chelating ligand has the formula: wherein Lig is a nitrogen containing macrocyclic metal ligand of the formula: V is selected from the group consisting of N and CR each R each p is independently an integer selected from the group consisting of 2, 3, and 4; R R each R