Patent ID: 9464125
Filing Date: 2016-10-11
CPC Classification: A61K,C07K,G01N

Claim Text:
1. A composition comprising an engineered cytotoxic stapled BH3 peptide comprising a fourteen amino acid sequence having the sequence of one of Trp-Val-Ala-Gln-Trp-Leu-Arg-Arg-Trp-Gly-Asp-Glu-Phe-Asn (SEQ ID NO: 2); Trp-Tyr-Ala-Gln-Ile-Leu-Arg-Arg-Met-Gly-Asp-Glu-Phe-Asn (SEQ ID NO: 3); Trp-Leu-Ala-Gln-Leu-Leu-Arg-Arg-Tyr-Gly-Asp-Glu-Phe-Asn (SEQ ID NO: 4); Trp-Ile-Ala-Gln-Ile-Leu-Arg-Arg-Trp-Gly-Asp-Glu-Phe-Asn (SEQ ID NO: 5); Trp-Val-Ala-Gln-Thr-Leu-Arg-Arg-Trp-Gly-Asp-Glu-Phe-Asn (SEQ ID NO: 6); Trp-Ile-Ala-Gln-Leu-Leu-Arg-Arg-Ile-Gly-Asp-Glu-Val-Asn (SEQ ID NO: 7); Trp-Val-Ala-Gln-Leu-Leu-Arg-Arg-Ile-Gly-Asp-Glu-Val-Asn (SEQ ID NO: 8); Trp-Met-Ala-Gln-Ile-Leu-Arg-Arg-Ile-Gly-Asp-Glu-Val-Asn (SEQ ID NO: 9); Trp-Leu-Ala-Gln-Leu-Leu-Arg-Arg-Ile-Gly-Asp-Glu-Ile-Asn (SEQ ID NO: 10); or Trp-Leu-Ala-Gln-Glu-Leu-Arg-Arg-Ile-Gly-Asp-Glu-Val-Asn (SEQ ID NO: 11) and a crosslink, wherein the crosslink is from amino acid side chain to amino acid side chain within the fourteen amino acid sequence, from amino acid side chain to peptide backbone within the fourteen amino acid sequence, or between the Arg residue at position 8 of the fourteen amino acid sequence or a replacement thereof and the Glu residue at position 12 of the fourteen amino acid sequence or a replacement thereof.