Patent ID: 9522899
Filing Date: 2016-12-20
CPC Classification: A61P,C07D

Claim Text:
1. A method for synthesizing the compound of Formula (I), comprising: (1) stirring the following compound of Formula (II) in a reaction system in the presence of potassium hydroxide, potassium carbonate, sodium hydroxide, sodium carbonate, cesium hydroxide, or cesium carbonate for 5 minutes to 6 hours; and adding the following compound of Formula (III) into a reaction system for stirred reaction, at a reaction temperature ranging from −20° C. to 80° C., for a reaction time ranging from 1 hour to 72 hours, to yield the corresponding compound of Formula (IV) in the reaction; and (2) ammonolyzing the compound of Formula (IV) from step (1) in an alkaline condition to yield the monoamide compound of Formula (IV′) and; then cyclizing the monoamide compound of Formula (IV′) in the presence of potassium carbonate in acetonitrile under reflux for five hours to yield the compound of Formula (I)