Patent ID: 9278080
Filing Date: 2016-03-08
CPC Classification: A61K,A61P

Claim Text:
1. A pharmaceutical composition comprising active ingredients in a solid dosage form suitable for oral administration, wherein the active ingredients of said composition consist of a pharmaceutically effective amount of: (i) a parietal cell activator, wherein the parietal cell activator is one or more small carboxylic acid molecules or any salts thereof which activate parietal cells without activating the gastrin-histamine pathway, wherein the small carboxylic acid molecules or any salts thereof are saturated or non-saturated monocarboxylic, dicarboxylic or tricarboxylic acid molecules or any salts thereof involved in the mitochondrial respiration circle (Krebs cycle) having between three to six carbon atoms selected from the group consisting of pyruvate, alpha-ketoglutarate, succinyl-CoA, and any salts thereof; and (ii) an irreversible gastric H + /K + -ATPase proton pump inhibitor (PPI), wherein the PPI is formulated as particles that are enteric coated, wherein the solid dosage form is suitable for administration to a human patient, wherein the solid dosage form disintegrates in the stomach, wherein the PPI is formulated for absorption in the small intestine and the carboxylic acid molecules or any salts thereof is in a form for release in the stomach in an amount sufficient to activate parietal cells located in the gastric lumen of the human patient, wherein the one or more small carboxylic acid molecules or salts thereof are formulated as particles that are in a delayed release formulation to synchronize activation of parietal cells in the gastric lumen with the absorption of the PPI in the small intestine to increase the effectiveness of the PPI, wherein the amount of the small carboxylic acid molecules or any salts thereof is between 50 and 2500 mg and the amount of PPI is between 1 and 400 mg, wherein the weight ratio between the one or more small carboxylic acid molecules or any salts thereof and the PPI is about 20:1 to about 1:5, wherein the carboxylic acid molecules or any salts thereof in conjunction with the PPI reduces gastric acid secretion in the stomach, and wherein the active ingredients are formulated in a single unit oral dosage form selected from the group consisting of multi-layered tablets, powders, pellets, granules, capsules, press-coat tablets, capsules comprising multiple beads, multi-particulate capsules, and suspension tablets.