Patent ID: 9334329
Filing Date: 2016-05-10
CPC Classification: A61P,C07K

Claim Text:
1. A polynucleotide comprising a nucleic acid sequence encoding an antibody comprising a heavy chain and a light chain, wherein (a) the heavy chain comprises a heavy chain variable region comprising three complementary determining regions (CDRs) from the amino acid sequence of SEQ ID NO:1 and a heavy chain constant region comprising the amino acid sequence of SEQ ID NO:9, wherein the hinge region of the heavy chain constant region comprises at least one amino acid insertion, deletion or substitution; and (b) the light chain comprises a light chain variable region comprising three complementary determining regions from the amino acid sequence of SEQ ID NO:2 and a light chain constant region comprising the amino acid sequence of SEQ ID NO:10 or a light chain constant region comprising the amino acid sequence of SEQ ID NO:10 and further comprising at least one amino acid insertion, wherein the antibody specifically binds to a carbohydrate epitope on a CD43 or a carcinoembryonic antigen (CEA) expressed by the nonhematopoietic cancer cells.