Patent ID: 9487517
Filing Date: 2016-11-08
CPC Classification: A61P,C07D

Claim Text:
1. A compound represented by the following general formula (1): wherein: W is selected from: 1) C1-C6 alkylene optionally substituted with a fluorine atom, 2) C2-C6 alkenylene, and 3) thiophene, X is a single bond, Y is an oxygen atom, m is 1; n is 1; R R 1) —CONR 2) —OR 3) —NR 4) —N(R 5) —N(R 6) —SO 7) C1-C2 alkyl optionally substituted with a group(s) independently selected from —COR R 1) a halogen atom, 2) cyano, 3) C1-C10 alkyl optionally substituted with a group(s) independently selected from hydroxycarbonyl, C1-C10 alkoxycarbonyl and aminocarbonyl, 4) C1-C10 haloalkyl, 5) C1-C10 alkoxy, R R 1) hydrogen, 2) C1-C10 alkyl optionally substituted with a group(s) independently selected from amino and C1-C10 alkylamino, 3) C1-C10 hydroxyalkyl, 4) C1-C10 haloalkyl, 5) C1-C10 heteroalkyl, 6) C1-C10 heteroalkyl optionally substituted with a group(s) selected from a hydroxyl group, C1-C10 alkylamino and C2-C10 alkenyl, 7) aryl, 8) heteroaryl, 9) aryl C1-C10 alkyl, 10) a heterocycle optionally substituted with C1-C10 alkyl, 11) —(CH 12) C1-C10 alkoxy, 13) C2-C10 alkenyl and 14) —NR R R R 1) a halogen atom, 2) C1-C10 alkyl optionally having C1-C10 alkylamino as a substituent(s), 3) C1-C10 haloalkyl, 4) a hydroxyl group, 5) C1-C10 hydroxyalkyl, 6) C1-C10 alkoxy optionally substituted with a group(s) independently selected from a halogen atom, a hydroxyl group, amino and C1-C10 alkylamino, 7) aryl optionally substituted with a group(s) selected from a halogen atom, a hydroxyl group, amino and C1-C10 alkylamino, 8) C1-C10 heteroalkyl optionally substituted with a group(s) independently selected from a halogen atom, a hydroxyl group, amino and C1-C10 alkylamino, 9) a heterocycle optionally substituted with C1-C10 alkyl, 10) heteroaryl optionally substituted with C1-C10 alkyl, 11) heterocyclyl C1-C10 alkyl, 12) —COR 13) —NR 14) —SO 15) C1-C10 alkoxy-C1-C10 alkyl optionally having a hydroxyl group(s) as a substituent(s) and 16) C1-C10 hydroxyalkyloxy, wherein the hydrogen atom of the hydroxyl group is optionally replaced by C1-C10 hydroxyalkyl, and the heterocycle may further form a spiro ring together with a 4- to 6-membered heterocycle, and the bonded 4- to 6-membered heterocycle optionally contains O and N as ring-forming elements in addition to carbon atoms, and the carbon atom(s) may be oxidized to form carbonyl, and the 4- to 6-membered heterocycle is optionally further substituted with C1-C10 alkyl; R 1) a hydroxyl group, 2) C1-C10 alkoxy, 3) NR 4) C1-C10 alkyl optionally substituted with a substituent(s) selected from a halogen atom, a hydroxyl group, C1-C10 alkoxycarbonyl or C1-C10 alkylamino; R 1) hydrogen, 2) C1-C10 alkyl optionally substituted with a group(s) selected from aryl, amino, C1-C10 alkylamino, C1-C10 alkylcarbonylamino and a hydroxyl group, 3) heteroaryl and 4) C1-C10 alkoxy; R R R R R R 1) C1-C10 alkyl optionally substituted with aryl, 2) amino, 3) C1-C10 alkylamino and 4) aryl optionally substituted with C1-C10 alkyl; R 1) hydrogen, 2) C1-C10 alkyl optionally substituted with a group(s) independently selected from R 3) cycloalkyl optionally substituted with a halogen atom(s) or a hydroxyl group(s), 4) a heterocycle optionally substituted with a group(s) independently selected from C1-C10 alkyl, C1-C10 alkylcarbonyl, C1-C10 alkoxy, C1-C10 alkoxycarbonyl, amino and a halogen atom, 5) C1-C10 heteroalkyl optionally substituted with a group(s) independently selected from a halogen atom and a hydroxyl group, 6) heteroaryl optionally substituted with a group(s) selected from C1-C10 alkyl, C1-C10 alkylcarbonyl, C1-C10 alkoxycarbonyl and a halogen atom and 7) cycloalkenyl optionally substituted with a group(s) selected from C1-C10 alkoxy, C1-C10 alkylamino, amino, a hydroxyl group and a halogen atom, wherein the cycloalkenyl optionally contains a carbonyl group; R 1) a halogen atom, 2) a hydroxyl group, 3) a C1-C10 alkylcarbonyloxy group, 4) —COR 5) amino, 6) C1-C10 alkylamino, 7) a heterocycle optionally substituted with a group(s) selected from C1-C10 alkyl, C1-C10 alkylcarbonyl, C1-C10 alkoxycarbonyl and a halogen atom and 8) cyano; R 1) hydrogen and 2) C1-C10 alkyl optionally substituted with a group(s) selected from a halogen atom, a hydroxyl group and aryl; R R 1) a halogen atom, 2) C1-C10 alkyl optionally substituted with a group(s) independently selected from C1-C10 alkylamino and C1-C10 alkylcarbonylamino, 3) C1-C10 haloalkyl, 4) a hydroxyl group, 5) C1-C10 hydroxyalkyl, 6) C1-C10 alkoxy optionally substituted with a group(s) independently selected from a halogen atom, a hydroxyl group, amino and C1-C10 alkylamino, 7) aryl optionally substituted with a group(s) independently selected from a halogen atom, a hydroxyl group, amino and C1-C10 alkylamino, 8) C1-C10 heteroalkyl optionally substituted with 1 to 2 groups independently selected from a halogen atom, a hydroxyl group, amino and C1-C10 alkylamino, 9) —COR 10) —NR R 1) C1-C10 alkyl optionally substituted with 1 to 3 substituents independently selected from: 2) aryl or aryl C1-C10 alkyl, 3) cycloalkyl optionally substituted with a halogen atom(s), 4) a heterocycle optionally substituted with a group(s) selected from C1-C10 alkyl, 5) C1-C10 alkoxy, wherein the alkyl group is optionally substituted with a group(s) independently selected from C1-C10 alkylcarbonylamino, amino, C1-C10 alkylamino and a hydroxyl group, 6) amino, 7) C1-C10 alkylamino, wherein the alkyl group is optionally substituted with a group(s) independently selected from C1-C10 alkylcarbonylamino, amino, C1-C10 alkylamino, hydroxycarbonyl and a hydroxyl group and 8) C2-C10 alkenyl; R 1) C1-C10 alkyl, 2) amino and 3) C1-C10 alkylamino, wherein the alkyl group is optionally substituted with a group(s) independently selected from amino, C1-C10 alkylamino and a hydroxyl group; R 1) hydrogen, 2) C1-C10 alkyl, 3) C1-C10 alkylcarbonyl, wherein the alkyl is optionally substituted with a hydroxyl group(s), 4) C1-C10 alkoxycarbonyl, 5) aminocarbonyl, 6) C1-C10 alkylaminocarbonyl and 7) heterocyclic carbonyl optionally substituted with C1-C10 alkyl; R 1) hydrogen and 2) C1-C10 alkyl optionally substituted with a group(s) independently selected from a halogen atom, a hydroxyl group, amino and C1-C10 alkylamino; R R 1) C1-C10 alkyl and 2) —NR R 1) hydrogen, 2) C1-C10 alkyl optionally substituted with a group(s) independently selected from: 3) aryl optionally substituted with a group(s) independently selected from a halogen atom, a hydroxyl group, amino and C1-C10 alkylamino, 4) cycloalkyl optionally substituted with a group(s) independently selected from a halogen atom and a hydroxyl group, 5) a heterocycle optionally substituted with a group(s) independently selected from C1-C10 alkyl, a halogen atom and aryl C1-C10 alkyl, 6) heteroaryl optionally substituted with C1-C10 alkyl and 7) C1-C10 alkylcarbonyl; R 1) hydrogen and 2) C1-C10 alkyl optionally substituted with a group(s) independently selected from a halogen atom, a hydroxyl group and aryl; R R 1) C1-C10 heteroalkyl optionally substituted with a hydroxyl group(s), and 2) C1-C10 alkyl optionally substituted with a hydroxyl group(s), R 1) C1-C10 alkyl optionally substituted with a halogen atom(s), wherein the alkyl group is optionally further substituted with a substituent(s) independently selected from R 2) cycloalkyl substituted with a group(s) independently selected from: 3) cyclohexyl, and 4) aryl optionally substituted with a group(s) independently selected from R with the proviso that when W is 1) C1-C6 alkylene optionally substituted with a fluorine atom, or 2) C2-C6 alkenylene, R R 1) a halogen atom, 2) cyano, 3) C1-C10 alkyl optionally substituted with a group(s) independently selected from: 4) C1-C10 haloalkyl, 5) cycloalkyl optionally substituted with a group(s) independently selected from a halogen atom and C1-C10 haloalkyl, 6) C1-C10 alkoxy optionally substituted with a halogen atom(s) or a C2-C6 alkenyl group(s), 7) —COR 8) C1-C10 heteroalkyl optionally substituted with a halogen atom(s), 9) aryl optionally substituted with a substituent(s) independently selected from: 10) heteroaryl optionally substituted with a C1-C10 alkyl group(s), 11) —SO 12) C1-C10 alkylthio optionally substituted with a halogen atom(s), 13) —Si(R 14) —SF R 1) hydrogen, 2) aryl optionally substituted with a group(s) independently selected from C1-C10 alkyl optionally substituted with halogen, a halogen atom and C1-C10 alkoxy, 4) C1-C10 alkoxycarbonyl, 7) C1-C10 alkoxycarbonylamino, 9) a hydroxyl group and 10) oxetane, tetrahydrofuran or tetrahydropyran optionally substituted with C1-C10 alkyl; 11) C4-C7 cycloalkyl, 12) C1-C10 alkoxy; R R R R 1) hydrogen, 2) C1-C10 alkyl optionally substituted with aryl and 3) aryl; R R