Patent ID: 9403840
Filing Date: 2016-08-02
CPC Classification: A61P,C07D

Claim Text:
1. A process for the preparation of a compound of formula (I): in which: R R3 and A together form a C or R3 represents a radical chosen from the group consisting of a hydrogen atom, a C in which a varies from 2 to 5, R4 and B together form a C or R4 represents a radical chosen from the group consisting of a hydrogen atom, a C or a pharmaceutically acceptable salt thereof, comprising the following successive stages: a) starting from podophyllotoxin of formula (VIII): b) if appropriate, preparation by demethylation of a compound of formula (V): c) reaction of the compound of formula (V) or (VIII) with chloroacetonitrile in an acidic medium and then, if appropriate, demethylation reaction, to provide a compound of formula (VI): d) reaction of the compound of formula (VI) with a compound of formula (VII):