Patent ID: 9238693
Filing Date: 2016-01-19
CPC Classification: A61K,A61P,C07H,C07K,C12N

Claim Text:
1. A method of treating asthma or asthma exacerbation comprising administering a therapeutically effective amount of an isolated monoclonal antibody or fragment thereof that binds human toll-like receptor 3 (TLR3) to a patient in need thereof for a time sufficient to treat asthma or asthma exacerbation, wherein the isolated antibody a. comprises a heavy chain complementarity determining region (CDR) 1 (HCDR1), 2 (HCDR2) and 3 (HCDR3) having the amino acid sequences as shown in SEQ ID NOs: 82, 86 and 84, respectively, and a light chain CDR 1 (LCDR1), 2 (LCDR2) and 3 (LCDR3) having the amino acid sequences as shown in SEQ ID NOs: 79, 80 and 87, respectively; b. comprises the VH of SEQ ID NO: 216 and the VL of SEQ ID NO: 41; c. comprises a HCDR1, HCDR2 and HCDR3 having the amino acid sequences as shown in SEQ ID NOs: 70, 77 and 72, respectively, and a LCDR1, LCDR2 and LCDR3 having the amino acid sequences as shown in SEQ ID NOs: 67, 68 and 78, respectively; or d. comprises the VH of SEQ ID NO: 214 and the VL of SEQ ID NO: 211.