Patent ID: 9408823
Filing Date: 2016-08-09
CPC Classification: A61K

Claim Text:
1. A modified release benzonatate solid oral composition comprising (a) a homogenous solid dispersion comprising (i) benzonatate adsorbed onto one or more of a silica, silicon dioxide or silicate to form a benzonatate adsorbate and (ii) at least one pharmaceutically acceptable modified release pH-independent, hydrophilic or hydrophobic matrix-forming substance in an amount effective to provide a modified release profile to the benzonatate, and (b) a coating over said homogenous solid dispersion, wherein there is substantially no benzonatate release from the composition in the buccal cavity, and wherein the composition provides a pharmacokinetic profile for benzonatate, based on an equivalent of about a 300 mg dose of benzonatate administered at 12 hour intervals in a 24 hour period, of one or more of: a geometric mean area under the curve (AUC)