Patent ID: 9365562
Filing Date: 2016-06-14
CPC Classification: A61P,C07D

Claim Text:
1. A compound of the formula I: wherein: X 1 , X 2 and X 3 independently are CH, or N R is selected from the group consisting of H, and C 1-6 alkyl; R 2 is selected from the group consisting of H, O—C 1-6 alkyl, C 1-6 alkyl, C 1-3 haloalkyl, (CH 2 ) n C 3-10 cycloalkyl, CN; (CH 2 ) n C 5-10 heterocycle, said alkyl, cycloalkyl, and heterocycle, optionally substituted with 1 to 3 groups of R a ; R 3 is selected from the group consisting of NRC(O)R 6 , C(O)OR 6 , and (CH 2 ) n C 5-10 heterocycle, said heterocycle, optionally substituted with 1 to 3 groups of R a ; R 5 is (CH 2 ) n C 6-10 aryl, (CH 2 ) n C 5-10 heterocycle, (CH 2 ) n C 3-10 cycloalkyl, said cycloalkyl, heterocycle, and aryl optionally substituted with 1 to 3 groups of R a ; R 6 is selected from the groups consisting of H, C 1-6 alkyl, OR, (CH 2 ) n C 3-10 cycloalkyl, —NH(CH 2 ) n OR, (CH 2 ) n C 6-10 aryl, —N(R) 2 , (CH 2 ) n C 6-10 heterocyle, said alkyl, cycloalkyl, heterocycle, and aryl optionally substituted with 1 to 3 groups of R a ; R a is selected from the group consisting of: (1) halogen, (2) hydroxyl, (3) C (4) —O—C (5) (CH (6) —O—(CH (7) —(CH (8) —O—(CH (9) —(CH (10) —O—(CH (11) —(CH (12) —NH—C (13) —O—(CH (14) —(CH (15) —CN, (16) —NO (17) —O) (18) C (19) C (20) C(O)R, (21) NH(CH R b is selected from the group consisting of: (1) halogen, (2) hydroxyl, (3) C (4) —O—C (5) (CH (6) (CH (7) C n represents 0-4; or a pharmaceutically acceptable salt thereof.