Patent ID: 9234184
Filing Date: 2016-01-12
CPC Classification: A61K,A61P,C07K,C12N,C12Q

Claim Text:
1. A nucleic acid comprising the nucleotide sequence shown in SEQ ID NO: 1, provided that when the nucleic acid is RNA, thymine (T) in the nucleotide sequence shown in SEQ ID NO: 1 shall be read as uracil (U), and comprising mutation(s) in the nucleotide sequence shown in SEQ ID NO: 1, wherein the mutation(s) cause substitution(s) of any of the following (i) to (iv) as defined on the basis of the amino acid sequence shown in SEQ ID NO: 14 (the amino acid sequence encoded by the sequence of nucleotide numbers from 342 to 9374 shown in SEQ ID NO: 1): (i) substitution of serine at position 2197 with tyrosine, (ii) substitution of serine at position 2204 with glycine, (iii) substitution of serine at position 2197 with tyrosine and substitution of glutamic acid at position 1202 with glycine, and (iv) substitution of serine at position 2204 with glycine and substitution of glutamic acid at position 1202 with glycine.