Patent ID: 9474731
Filing Date: 2016-10-25
CPC Classification: A61K

Claim Text:
1. A method of increasing the metabolic lifetime of dextromethorphan, comprising co-administering dextromethorphan with bupropion, hydroxybupropion, erythrohydroxybupropion, or threohydroxybupropion, to a human being who is an extensive metabolizer of dextromethorphan in need of treatment with dextromethorphan, once or twice a day for at least eight consecutive days, wherein bupropion, hydroxybupropion, erythrohydroxybupropion, or threohydroxybupropion is administered in an amount that results in a C min of dextromethorphan in the human being, on the eighth day, that is at least about 20 ng/mL and is at least 20 times the C min that would have been achieved by administering the same amount of dextromethorphan without bupropion, hydroxybupropion, erythrohydroxybupropion, or threohydroxybupropion for eight consecutive days, and wherein dextromethorphan is present in the body of the human being at the same time as bupropion, hydroxybupropion, erythrohydroxybupropion, or threohydroxybupropion.