Patent ID: 9486494
Filing Date: 2016-11-08
CPC Classification: A61K,A61P,C07K

Claim Text:
1. A composition comprising a guanylate cyclase receptor agonist (GCRA) peptide consisting essentially of the sequence of any one of 1-44, 56-90, 99-107, 109-173, 175-207, 209-249, 251-291, 302-311, 313-346, 371, and 372 and 5-aminosalicyclic acid (5-ASA) or a derivative or a pharmaceutically acceptable salt thereof, wherein said 5-ASA or derivative or pharmaceutically acceptable salt thereof is covalently linked to the N terminus and/or the C terminus of said peptide, wherein said composition comprises a glycosidic bond between the peptide and sugar residues of the 5-ASA molecule, and wherein when said glycosidic bond is cleaved, the peptide and 5-ASA molecule are released to produce a colon-specific effect.