Patent ID: 9506116
Filing Date: 2016-11-29
CPC Classification: C12Q

Claim Text:
1. A method for characterizing a biological sample comprising: (a) measuring a methylation level of a CpG site for two or more genes selected from ADCY1, c13orf18, CD1D, CLEC11A, ELMO1, IKZF1, PRKCB, RSPO3, ST8SIA1, and TWIST1 in a biological sample of a human individual through treating genomic DNA in the biological sample with bisulfite; (b) comparing the methylation level to a methylation level of a corresponding set of genes in control samples without neoplasm; and (c) determining that the individual has neoplasm when the methylation level measured in the two or more genes is lower than the methylation level measured in the respective control samples.