Patent ID: 9464301
Filing Date: 2016-10-11
CPC Classification: C12N,C12P,C12Y,Y02P

Claim Text:
1. A method of increasing the rate or flux of production of 3,3-dimethylallyl diphosphate (DMAPP), isopentenyl diphosphate (IPP), or a product derived from DMAPP and/or IPP comprising: culturing recombinant cells comprising (i) one or more heterologous non-modified nucleic acids encoding feedback-resistant mevalonate kinase polypeptides, and (ii) one or more nucleic acids encoding a mevalonate (MVA) pathway polypeptide, wherein the cells are cultured under suitable culture conditions for increasing the rate or flux of production of DMAPP, IPP, or a product derived from DMAPP or IPP, thereby increasing the rate or flux of production of DMAPP, IPP, or a product derived from DMAPP and/or IPP.