Patent ID: 9315569
Filing Date: 2016-04-19
CPC Classification: A61K,A61P,C07K,G01N,Y10S

Claim Text:
1. A method of treating a neurodegenerative disorder with α-synuclein pathology in an individual, or delaying onset of a neurodegenerative disorder with α-synuclein pathology in an individual at risk of developing the disorder, wherein the disorder with α-synuclein pathology is selected from the group consisting of Parkinson's disease (PD), dementia with Lewy bodies (DLB), the Lewy body variant of Alzheimer's disease, and multiple system atrophy (MSA), comprising administering to the individual an antibody which is produced from a stabilized soluble α-synuclein oligomer and capable of binding a stabilized soluble α-synuclein oligomer, the stabilized soluble α-synuclein oligomer comprising a soluble α-synuclein oligomer modified with 4-hydroxy-2-nonenal, 4-oxo-2-nonenal, or a combination thereof and having a lower formation rate to a non-soluble aggregated form than a non-stabilized soluble oligomer of the α-synuclein, and the α-synuclein oligomer comprising wild type α-synuclein of SEQ ID NO: 1, wherein the antibody is capable of binding wild type soluble α-synuclein oligomers.