Patent ID: 9370558
Filing Date: 2016-06-21
CPC Classification: A61K

Claim Text:
1. A method for eliciting an anti-tumor immune response, comprising contacting or implanting into a subject a device comprising a polymeric structure composition, a tumor antigen, and a TLR3 agonist, wherein the TLR3 agonist comprises condensed polyinosine-polycytidylic acid (poly I:C) cationic nanoparticles, wherein said anti-tumor immune response comprises activation of a CD8+ dendritic cell, a plasmacytoid dendritic cell, or a CD141+ dendritic cell, and wherein said tumor comprises a solid tumor, said condensed poly I:C cationic nanoparticles being formed by mixing said poly I:C with a polycation comprising positively charged amine groups at a charge ratio resulting in positively charged condensates and an average particle size of 98-545 nm.