Patent ID: 9422527
Filing Date: 2016-08-23
CPC Classification: A61K,C07C,C07K,C12N,C12Q,G01N,G16B,G16C

Claim Text:
1. A method of identifying an inhibitor of the binding of human immunodeficiency virus (HIV) glycoprotein 120 (gp120) to a CD4-receptor or to the integrin alpha4 beta7 (a4b7), the method comprising: (a) bringing into contact a HIV gp120 or a peptidomimetic reflecting the three-dimensional structure of said gp120 and a test compound; (b) determining whether said test compound interacts with at least two amino acid residues found independently in each of three of six motifs, said three of six motifs selected from the group consisting of motif 1, motif 2 and motif 3, within the 3-dimensional structure of said gp120 or within a peptidomimetic reflecting the 3-dimensional structure of said gp120, (c) identifying those compounds which interact with at least two amino acid residues found independently in any three motifs selected from the group consisting of motif 1, motif 2 and motif 3, in said six motifs within the 3-dimensional structure of said gp120 in (b).