Patent ID: 9233119
Filing Date: 2016-01-12
CPC Classification: A61K,C12N

Claim Text:
1. An sDNA aptamer for suppressing the carcinogenic activity of High Mobility Group A (HMGA) proteins in human cells having a nucleotide sequence comprising a segment selected from the group consisting of: 5′-G*G*G*A*A*A*A*A*A*T*T*T*T*T*T*A*A*A*A*A*A*-C*C*C-3′ (SEQ ID NO: 1); 5′-C*C*C*A*A*A*A*A*A*A*A*A*A*A*A*A*A*A*C*C*C-3′ (SEQ ID NO: 2); 5′-G*G*G*T*T*T*T*T*T*T*T*T*T*T*T*T*T*T*G*G*G-3′ (SEQ ID NO: 3); 5′-GGGT*T*T*T*T*T*T*T*T*T*CGCGGCGGCCCCGCG-3′ (SEQ ID NO: 5); 5′-CC*CA*AA*AA*AA*AA*AA*AA*AA*CC*C-5′ (SEQ ID NO: 10), and 5′-G*GG*TT*TT*TT*TT*TT*TT*TT*TG*GG-3′ (SEQ ID NO: 11); wherein are phosphorothioate linkages.