Patent ID: 9400276
Filing Date: 2016-07-26
CPC Classification: G01N

Claim Text:
1. A method for detecting the presence of a nucleosome containing a histone variant or histone isoform associated with a cell free nucleosome in a body fluid sample which comprises the steps of: (i) contacting the body fluid sample with a first binding agent which binds to nucleosomes; (ii) contacting the nucleosomes or body fluid sample with a second binding agent which binds to the histone variant or histone isoform; (iii) detecting or quantifying the binding of said second binding agent to histone variant or histone isoform in the body fluid sample; and (iv) using the presence or degree of such binding as a measure of the presence of nucleosomes containing the histone variant or histone isoform in the body fluid sample.