Patent ID: 9296788
Filing Date: 2016-03-29
CPC Classification: A61K,A61P,C07K,C12N

Claim Text:
1. A method for inhibiting growth of cancer cells in an individual, wherein the cancer cells have constitutively active Abl tyrosine kinase activity, the method comprising administering to the individual a modified protein kinase C (PKC) bII, wherein the modified PCKbII comprises an Abl tyrosine kinase target motif, wherein the Abl tyrosine target motif is the eight amino acid sequence beginning at position 21 in SEQ ID NO:10, through amino acid position 28 in SEQ ID NO:10, wherein the modified PKC bII is phosphorylated by a Bcr-Abl protein expressed by the cancer cells, and wherein the growth of the cancer cells is inhibited subsequent to phosphorylation of the modified PKC bII by the Bcr-Abl protein.