Patent ID: 9284333
Filing Date: 2016-03-15
CPC Classification: A61P,C07D

Claim Text:
1. A compound of the formula I, in any of its stereoisomeric forms or a mixture of stereoisomeric forms in any ratio, or a pharmaceutically acceptable salt thereof, wherein n is selected from the series consisting of 0 and 1; m is selected from the series consisting of 0, 1 and 2, with the proviso that m and n cannot simultaneously be 0; X is selected from the series consisting of oxygen, sulfur and (R10)(R11)C; one of the groups R1 and R2 is the group R20-NH— and the other of the groups R1 and R2 is the group (R30)(R31)N—; R3 is selected from the series consisting of hydrogen, halogen and (C R4, R5, R6, R7, R8, R9, R10 and R11 are independently of one another selected from the series consisting of hydrogen, fluorine and (C R20 is selected from the series consisting of (C R21 is selected from the series consisting of phenyl and Het1, which are all unsubstituted or substituted by one or more identical or different substituents R24; R22 is selected from the series consisting of hydrogen, (C R23 is selected from the series consisting of hydrogen and (C R24 is selected from the series consisting of halogen, (C R25 is selected from the series consisting of (C R30 is selected from the series consisting of hydrogen, (C R31 is selected from the series consisting of (C or the groups R30 and R31, together with the nitrogen atom carrying them, form a 4-membered to 10-membered, monocyclic or bicyclic, saturated or partially unsaturated heterocycle which, in addition to the nitrogen atom carrying R30 and R31, comprises 0 or 1 further ring heteroatom selected from the series consisting of nitrogen, oxygen and sulfur, and which is unsubstituted or substituted by one or more identical or different substituents R36; R32 is selected from the series consisting of hydrogen and (C R33 is selected from the series consisting of hydrogen, (C or R32 and R33, together with the carbon atom carrying them, form a (C R34 is selected from the series consisting of hydrogen, (C R35 is selected from the series consisting of halogen, (C R36 is selected from the series consisting of fluorine, (C R37 is selected from the series consisting of (C R38 is selected from the series consisting of phenyl, HO— and (C R39, R40, R42, R47, R49, R50 and R51 are independently of one another selected from the series consisting of hydrogen and (C R41 is selected from the series consisting of (C R43, R44, R45 and R46 are independently of one another selected from the series consisting of hydrogen, (C R48 is selected from the series consisting of (C p is selected from the series consisting of 0, 1 and 2, wherein all numbers p are independent of one another; Het1 is a 5-membered or 6-membered, monocyclic, aromatic heterocycle comprising 1 or 2 identical or different ring heteroatoms selected from the series consisting of nitrogen, oxygen and sulfur, which is bonded via a ring carbon atom and which is unsubstituted or substituted by one or more identical or different substituents selected from the series consisting of halogen, (C Het2 is a 4-membered to 10-membered, monocyclic or bicyclic, saturated, partially unsaturated or aromatic heterocycle comprising 1, 2, 3 or 4 identical or different ring heteroatoms selected from the series consisting of nitrogen, oxygen and sulfur, which is bonded via a ring carbon atom and which is unsubstituted or substituted by one or more identical or different substituents selected from the series consisting of halogen, (C Het3 is a 4-membered to 7-membered, monocyclic, saturated, partially unsaturated or aromatic heterocycle comprising 1, 2 or 3 identical or different ring heteroatoms selected from the series consisting of nitrogen, oxygen and sulfur, which is unsubstituted or substituted by one or more identical or different substituents selected from the series consisting of halogen, (C wherein all phenyl groups are unsubstituted or substituted by one or more identical or different substituents selected from the series consisting of halogen, (C wherein all cycloalkyl groups, independently of any other substituents which can be present on a cycloalkyl group, can be substituted by one or more identical or different substituents selected from the series consisting of fluorine and (C wherein all alkyl groups, alkanediyl groups, alkenyl groups and alkynyl groups, independently of any other substituents which can be present on an alkyl group, can be substituted by one or more fluorine substituents.