Patent ID: 9475865
Filing Date: 2016-10-25
CPC Classification: A61K,A61P,C07K

Claim Text:
1. A method for treating mesothelioma, which comprises delivering directly to a mesothelioma tumor; A) a polynucleotide encoding REIC/Dkk-3 protein consisting of the amino acid sequence set forth in SEQ ID NO: 2, wherein said protein has apoptosis activity in mesothelioma tumor cells, or B) a polynucleotide encoding a polypeptide fragment of the amino acid sequence set forth in SEQ ID NO: 2, wherein the polypeptide fragment has apoptosis activity in mesothelioma tumor cells, and wherein the polynucleotide consists of a nucleotide sequence encoding any of the following (a), (b) and (c): (a) a polypeptide consisting of amino acid 1 to any of amino acids 39 to 78 of the sequence set forth in SEQ ID NO: 2; (b) a polypeptide consisting of the amino acid sequence set forth in SEQ ID NO: 4; or (c) a polypeptide consisting of the amino acid sequence set forth in SEQ ID NO: 6, wherein said delivering results in tumor growth suppression.