Patent ID: 9320738
Filing Date: 2016-04-26
CPC Classification: A61K,A61P,C12Y

Claim Text:
1. An oral pharmaceutical composition comprising 5-fluorocytosine (FC), wherein the pharmaceutical composition is a monolithic solid tablet form comprising at least one hydrophilic matrix forming polymer of about 5 weight percent to about 40 weight percent, at least one diluent of about 10 weight percent to about 40 weight percent and at least one binder of about 0.5 weight percent to about 30 weight percent and wherein the pharmaceutical composition is restricted to the upper gastrointestinal tract and releases 5-FC into the upper gastrointestinal tract of a subject over a sustained period of time, wherein the composition has an in vitro 5-FC dissolution rate of less than 33% at 0.5 hours in pH 1.2.