Patent ID: 9365607
Filing Date: 2016-06-14
CPC Classification: C07B,C07H,C12N

Claim Text:
1. A modified ribo-oligonucleotide having the formula comprising: wherein D is deuterium; B is a nucleobase; n is a number greater than 1 and represents the number of nucleosides in the oligonucleotide; W is oxygen or sulfur; Y is oxygen, C1-C18 alkoxy, C1-18 alkyl; NHR3 with R3 being C1-C18 alkyl or C1-C4 alkoxy-C1-C6-alkyl; NR3R4 in which R3 is C1-C18 alkyl or C1-C4 alkoxy-C1-C6-alkyl and R4 is C1-C18 alkyl, or in which R3 is C1-C18 alkyl or C1-C4 alkoxy-C1-C6-alkyl and R4 is C1-C18-alkyl, or in which R3 and R4 form together with the nitrogen atom carrying them, a 5-6 membered heterocyclic ring which can additionally contain another hetero atom from the series O, S and N; said modified ribo-oligonucleotide having at least one phosphate group having a 5 prime to 5 prime linkage, wherein at least one phosphate group links the 5 prime carbon of one nucleoside to the 5 prime carbon of a second, independent nucleoside.