Patent ID: 9233171
Filing Date: 2016-01-12
CPC Classification: A61K,A61P,C07K

Claim Text:
1. A method of treating cancer in a human patient comprising administering an amount of an epidermal growth factor receptor (EGFR) antibody immunoconjugate to a human patient with a tumor comprising tumor cells that are resistant or refractory to an EGFR antibody therapy, effective to inhibit growth of the tumor; wherein the immunoconjugate has the formula (A)-(L)-(C), wherein: (A) is an antibody or antigen binding fragment thereof that specifically binds EGFR and comprises the heavy chain variable region of SEQ ID NO:1 and the light chain variable region of SEQ ID NO:2 or SEQ ID NO:3; (L) is a linker; and (C) is a maytansinoid or maytansinoid analog; and wherein said linker (L) links (A) to (C).