Patent ID: 9433700
Filing Date: 2016-09-06
CPC Classification: A61L

Claim Text:
1. A tissue sealant comprising: an adhesive material that is activated to form a seal when contacted with a biological tissue; and an optical dye noncovalently associated with the adhesive material; wherein the optical dye exhibits a first optical condition prior to activation of the adhesive material and exhibits a second optical condition that is distinguishable from the first optical condition after activation of the adhesive material, wherein the first optical condition of the optical dye is a first fluorescence quantum yield prior to activation of the adhesive material and the second optical condition of the optical dye is a second fluorescence quantum yield after activation of the adhesive material, wherein the second fluorescence quantum yield is different from the first fluorescence quantum yield; wherein the first fluorescence quantum yield is substantially equal to 0 and the second fluorescence quantum yield is greater than or equal to 0.01, or wherein the second fluorescence quantum yield is greater than the first fluorescence quantum yield by at least a factor of 1.5 or is less than the first fluorescence quantum yield by at least a factor of 1.5, wherein activation of the adhesive material incorporates the optical dye into the tissue seal, fibrin network, or clot; immobilizes the optical dye in the tissue seal, fibrin network, or clot, or rigidifies the optical dye, thereby providing a change from the first optical condition to the second optical condition; and wherein activation of the adhesive material initiates a coagulation cascade in a subject.