Patent ID: 9510569
Filing Date: 2016-12-06
CPC Classification: A01K,C07K,C12N

Claim Text:
1. A genetically modified mouse whose genome comprises a modified mouse Activin A receptor type 1 (Acvr1) gene comprising: i) a human exon 5 of the Acvr1 gene encoding glutamic acid at the first codon instead of aspartic acid in sense orientation flanked upstream and downstream by first pair of recombination recognition sites; and ii) a mutant exon 5 of a mouse Acvr1 gene comprising an R206H mutation in antisense orientation flanked upstream and downstream by second pair of recombination recognition sites that are different than the first pair of recombination recognition sites; wherein the first and second recombination recognition sites are oriented so that a recombinase can invert the mutant exon 5 into sense orientation, delete the human exon 5, and allow a mutant Acvr1 comprising the mutant exon 5 to be expressed resulting in ectopic bone formation.