Patent ID: 9435814
Filing Date: 2016-09-06
CPC Classification: G01N

Claim Text:
1. A method for diagnosing obstructive sleep apnea in a subject, comprising: (a) providing a biological sample from the subject; (b) determining an amount in the sample of a Urocortin III peptide; and (c) comparing the amount of the Urocortin III peptide in the sample, if present, to a control level of the Urocortin III peptide, wherein the subject is diagnosed as having obstructive sleep apnea if there is a measurable increase in the amount of the Urocortin III peptide in the sample as compared to the control level, wherein determining the amount in the sample of the Urocortin III peptide comprises determining the amount in the sample using mass spectrometry (MS) analysis, immunoassay analysis, or both, wherein the mass spectrometry (MS) analysis is selected from the group consisting of liquid-chromatography mass spectrometry (LC-MS), electrospray ionization mass spectrometry (ESI-MS), matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF-MS), and surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF-MS), and wherein the immunoassay analysis is selected from the group consisting of an enzyme-linked immunosorbent assay (ELISA) and an immunoturbidimetric assay.