Patent ID: 9320829
Filing Date: 2016-04-26
CPC Classification: A61F,A61L

Claim Text:
1. An implantable medical device having a lumen, a luminal surface, a tissue-contacting surface, and a coating; said coating comprising: (i) one or more luminal surface layers of a biocompatible matrix comprising a natural or synthetic polymer or combinations thereof, and a therapeutically effective amount of a ligand covalently bound to said matrix, said bound ligand selected from an antibody, an antibody fragment and combinations thereof, configured specifically to bind to a cell surface antigen or cell membrane molecule comprising CD133, CD34, CD31, CDw90, CD117, VEGFR-1, VEGFR-2, Muc-18 (CD146), CD130, stem cell antigen (Sca-1), stem cell factor 1 (SCF/c-Kit ligand), HLA-DR, HAD-DR, VEGFR-3, Tie-1, Thy-1, Thy-2, CD30, VE-cadherin, P1H12, TEK, Ang-1, Ang-2, Tie-2, or combinations thereof of circulating endothelial progenitor cells or endothelial cells in peripheral blood for capture and proliferation of said endothelial progenitor cells or endothelial cells to form an endothelial layer on said luminal surface of the implantable medical device; and (ii) at least one layer of tissue-contacting biodegradable and biocompatible synt-hee polymer matrix, comprising one or more therapeutically effective amounts of one or more pharmaceutical substances that inhibit smooth muscle cell proliferation and/or migration.