Patent ID: 9278076
Filing Date: 2016-03-08
CPC Classification: A61K,A61P

Claim Text:
1. A delayed release oral solid dosage form comprising: a tablet core comprising a mixture of a therapeutically effective amount of a drug and a pharmaceutically acceptable surfactant selected from the group consisting of (i) an anionic surfactant selected from the group consisting of monovalent alkyl carboxylates, acyl lactylates, alkyl ether carboxylates, N-acyl sarcosinates, polyvalent alkyl carbonates, N-acyl glutamates, fatty acid-polypeptide condensates, sulfuric acid esters, alkyl sulfates, ethoxylated alkyl sulfates, ester linked sulfonates, alpha olefin sulfonates, phosphated ethoxylated alcohols and mixtures thereof; (ii) a cationic surfactant selected from the group consisting of monoalkyl quaternary ammonium salts, dialkyl quaternary ammonium compounds, amidoamines, and aminimides, and mixtures thereof; (iii) an amphoteric surfactant selected from the group consisting of N-substituted alkyl amides, N-alkyl betaines, sulfobetaines, N-alkyl 6-aminoproprionates, and mixtures thereof; (iv) a polyethylene glycol, a polyethyleneglycol ester, a polyethyleneglycol ether, and mixtures thereof; and (v) a mixture of any of (i)-(iv); the surfactant comprising about 2.8 or from about 5 to about 50% of the core, by weight; and a delayed release material compression coated onto said core, said delayed release material comprising one or more natural or synthetic gums, said compression coating delaying the release of said drug from said dosage form until after a period of time from about 2 to about 18 hours after exposure of the dosage form to an aqueous solution; wherein the surfactant is included in an amount sufficient to facilitate the complete release of the drug from the dosage form in less than about 4 hours after initial release of the drug from the delayed release oral solid dosage form.