Patent ID: 9388148
Filing Date: 2016-07-12
CPC Classification: A61K,A61P,C07D

Claim Text:
1. A compound, selected from the group consisting of Trans-N-[4-[2-[(3S)-4-(2-tert-butyl-6-isopropyl-pyrimidin-4-yl)-3-methyl-piperazin-1-yl]ethyl]cyclohexyl]-trans-4-hydroxy-cyclohexanecarboxamide; N-[3-[2-[(3S)-4-(2-tert-butyl-6-isopropyl-pyrimidin-4-yl)-3-methyl-piperazin-1-yl]ethyl]cyclobutyl]-trans-4-hydroxy-cyclohexanecarboxamide; Cis-N-[4-[2-[4-(2-tert-butyl-6-isopropyl-pyrimidin-4-yl)piperazin-1-yl]ethyl]cyclohexyl]-trans-4-hydroxy-cyclohexanecarb oxamide; Cis-N-[4-[2-[(3S)-4-[2-tert-butyl-6-(difluoromethyl)pyrimidin-4-yl]-3-methyl-piperazin-1-yl]ethyl]cyclohexyl]-trans-4-hydroxy-cyclohexanecarboxamide; trans-N-[(1S)-3-[2-[(3S)-4-(2-tert-butyl-6-isopropyl-pyrimidin-4-yl)-3-methyl-piperazin-1-yl]ethyl]cyclopentyl]-4-hydroxy-cyclohexanecarboxamide; trans-N-[4-[2-[(3S)-4-(2-tert-butyl-6-isopropyl-pyrimidin-4-yl)-3-methyl-piperazin-1-yl]ethyl]cyclohexyl]-4-hydroxy-cyclohexanecarboxamide; trans-N-[4-[2-[(3S)-4-(2-tert-butyl-6-isopropyl-pyrimidin-4-yl)-3-methyl-piperazin-1-yl]ethyl]cyclohexyl]-3-methoxy-cyclobutanecarboxamide; trans-N-[4-[2-[(3S)-4-(2-tert-butyl-6-isopropyl-pyrimidin-4-yl)-3-methyl-piperazin-1-yl]ethyl]cyclohexyl]-3-hydroxy-cyclobutanecarboxamide; trans-N-[4-[2-[4-(2-tert-butyl-6-isopropyl-pyrimidin-4-yl)-piperazin-1-yl]ethyl]cyclohexyl]-3-methoxy-cyclobutanecarboxamide; and trans-N-[4-[2-[4-(2-tert-butyl-6-isopropyl-pyrimidin-4-yl)-piperazin-1-yl]ethyl]cyclohexyl]-3-hydroxy-cyclobutanecarboxamide; or an N-oxide, or a pharmaceutically acceptable salt thereof.