Patent ID: 9321774
Filing Date: 2016-04-26
CPC Classification: A61P,C07D

Claim Text:
1. A compound of formula I: or a pharmaceutically acceptable salt thereof, wherein: the dotted double bond indicates the presence of a single or double bond between C2 and C3; R R where R and R′ are independently selected from optionally substituted C —F, —Cl, —Br, —I, —OH, —OR 24 , —CH(OR 21 )(OR 21 ), —CH(OH)(OR 21 ), —CR(OR 21 )(OR 21 ), ═O, ═S, ═NR 22 , —C(═O)R 21 , —C(═O)OH, —C(═S)SH, —C(═O)SH, —C(═S)OH, —C(═NH)OH, —C(═NOH)OH, —C(═O)OR 21 , —OC(═O)R 21 , —OC(═O)OR 21 , —NR 23 R 23 , —C(═O)NR 23 R 23′ , —C(═S)NR 23 R 23′ , —NR 22 C(═O)R 21 , —OC(═O)NR 23 R 23′ , —N(R 22 )CONR 23 R 23′ , —NH—C(═NH)NH 2 , ═NR 22 , —C(═NR 22 )N(R 22 ) 2 , —NO 2 , —NO, —N 3 , —CN, —NC, —OCN, —NCO, —SCN, —NCS, —SH, —SR 21 , —SS—R 21 , —S(═O)R 21 , —S(═O)R 21 , —S(═O)OH, —S(═O) 2 OH, —S(═O)OR 21 , —S(═O) 2 OR 21 , —OS(═O)R 21 , —OS(═O)R 21 , —OS(═O) 2 OR 21 , —S(═O)NR 23 R 23′ , —S(═O) 2 NR 23 R 23′ , —NR 22 S(═O) 2 OH, —NR 22 S(═O) 2 R 21 , —NR 22 S(═O)R 21 , —PR 22 2 , —P(═O) 2 , —P(═O)(R 21 ) 2 , —P(═O)(OH) 2 , —P(═O)(OR 22 ) 2 , —OP(═O)(OH) 2 , —OP(═O)(OR 22 ) 2 , —OP(OH) 2 , —OP(OR 22 ) 2 , —OP(OR 22 )—N(R 22 ) 2 ; and —OP(═O)(OR 22 )—N(R 22 ) 2 wherein each R 21 is independently selected from C 1-7 alkyl, a C 3-20 heterocyclyl, or a C 5-20 aryl; each R 22 is independently selected from hydrogen C 1-7 alkyl, a C 3-20 heterocyclyl or a C 5-20 aryl; each R 23 is independently selected from hydrogen C 1-7 alkyl a C 3-20 heterocyclyl a C 5-20 or, in the case of a “cyclic” amino group, R 23 and R 23′ , taken together with the nitrogen atom to which they are attached, form a heterocyclic ring having from 4 to 8 ring atoms; each R 24 is independently alkyl; and each R 25 is independently selected from optionally substituted C 1-7 alkyl a C 3-20 heterocyclyl, or a C 5-20 aryl; R A is selected from A1, A2, A3, A4 or A5: Where X X N and S; N and O; and CH and O, respectively; Z Z F is selected from a single bond and -(E-F each E is independently selected from a single bond, and —C(═O)—NH—; each F m is 1, 2 or 3; G is selected from hydrogen, C each n is 0-4; wherein C wherein C provided that A2 is not A2: where X provided that A3 is not A3′: where X B is either a single bond or: where X and Y of B1 are selected from: CH and NMe; COH and NMe; CH and S; N and NMe; N and S, respectively; and R