Patent ID: 9352036
Filing Date: 2016-05-31
CPC Classification: A61K,C07K,Y02A

Claim Text:
1. A method of delivering a therapeutic agent to a human subject comprising: a) administering to the human subject a bispecific antibody construct comprising a first antibody or antigen-binding fragment thereof that binds to a target antigen and a second antibody or antigen-binding fragment thereof that binds to a hapten; and b) administering to the human subject a peptide targetable construct comprising (i) one or more copies of the hapten, (ii) a dendron conjugated to the peptide, and (iii) two or more copies of the therapeutic agent conjugated to the dendron, wherein the first antibody is selected from the group consisting of hR1 (anti-IGF-IR), hPAM4 (anti-mucin), hA20 (anti-CD20), hA19 (anti-CD19), hIMMU31 (anti-AFP), hLL1 (anti-CD74), hLL2 (anti-CD22), hMu-9 (anti-CSAp), hL243 (anti-HLA-DR), hMN-14 (anti-CEACAM5), hMN-15 (anti-CEACAM6), hRS7 (anti-EGP-1), hMN-3 (anti-CEACAM6), Ab124 (anti-CXCR4) and Ab125 (anti-CXCR4); wherein the hapten is histidine-succinyl-glycine (HSG) or Indium diethylene triamine pentaacetic acid (In-DTPA); and wherein the human subject has cancer expressing the target antigen.