Patent ID: 9297814
Filing Date: 2016-03-29
CPC Classification: G01N

Claim Text:
1. A preoperative method of determining a greater likelihood that an adnexal mass in a female subject is malignant or benign, comprising providing a blood sample collected from the subject; isolating serum or plasma from the blood sample to obtain a serum or plasma sample; determining a total calcium level and an albumin level in the serum or plasma sample; comparing the total calcium level and the albumin level of the serum or plasma sample to a multivariable generalized additive predictive model that includes total serum or plasma calcium and albumin for a population including patients with malignant ovarian masses and patients with benign ovarian masses, and the age and body mass of the population as covariates, wherein a model output is scaled as a range; and providing a predictive score for the female subject based upon the comparison; and determining that the adnexal mass in the female subject is likely to be malignant or likely to be benign based on the predictive score for the female subject.