Patent ID: 9492444
Filing Date: 2016-11-15
CPC Classification: A61K,B29C,B29K

Claim Text:
1. An oral, extended release, abuse deterrent pill comprising: (i) 4 wt % to 35 wt % of an active substance susceptible to abuse, wherein the active substance is oxycodone, hydrocodone, hydromorphone, morphine, methadone, or pharmaceutical acceptable salts thereof; (ii) 38 wt % to 42 wt % of polyethylene oxide as a matrix agent, wherein the matrix agent has an average molecular weight between 50K Daltons and 150K Daltons; (iii) 15 wt % to 45 wt % of hydroxypropyl methylcellulose as a controlled release agent; (iv) 0.2 wt % to 20 wt % polyethylene glycol as a plasticizer; wherein the active substance susceptible to abuse has an extended release profile, wherein the pill exhibits less than a 10% increase in the release of the active substance in a simulated alcoholic gastric fluid environment, wherein the pill has at least 50 wt % of particles with a particle size greater than 0.5 mm following physical or mechanical manipulation of the pill, and wherein the pill is a formed, uniform extrudate having a uniform blend of active, matrix agent, controlled release agent and plasticizer, and is directly formed from an extrusion process.