Patent ID: 9366684
Filing Date: 2016-06-14
CPC Classification: A61K,C07K,C12Y,G01N

Claim Text:
1. A method of treating at least one condition associated with increased coagulation activity in a subject in need thereof, the method comprising the steps of: determining increased heparanase procoagulant activity in the subject, comprising administering to the subject a pharmaceutical composition comprising an inhibitor selected from the group consisting of anti-Xa derivatives, unfractionated heparin, low molecular weight heparins, fondaparinux, rivaroxaban, enoxaparin, tissue factor pathway inhibitor 1 and derivatives thereof, a tissue factor pathway inhibitor 2 and derivatives thereof, a peptide of SEQ ID: 1, a peptide of SEQ ID: 2, a peptide of SEQ ID: 3, a peptide of SEQ ID: 4, a peptide of SEQ ID: 5, a peptide of SEQ ID: 6, and a peptide of SEQ ID: 7, wherein said subject is suffering from a pathologic condition associated with increased coagulation activity, selected from the group consisting of a pathologic condition associated with contraceptive treatments, proliferative disorders, inflammatory diseases, orthopedic surgery, diabetic foot, endometriosis, pregnancy vascular complications, cardiovascular complications, hyperplasia, and avascular necrosis of hip.