Patent ID: 9364440
Filing Date: 2016-06-14
CPC Classification: A61K,A61P

Claim Text:
1. A delayed release drug formulation for oral administration to deliver a drug to the colon of a subject, said formulation comprising: a core and a coating for the core, the core comprising a drug and the coating comprising an outer layer and at least one layer between the core and the outer layer selected from the group consisting of an isolation layer and an inner layer, said outer layer comprising a mixture of a first polymeric material which is susceptible to attack by colonic bacteria and a second polymeric material which has a pH threshold at about pH 5 or above, said inner layer comprising a third polymeric material which is soluble in intestinal fluid or gastrointestinal fluid, said third polymeric material being selected from the group consisting of a polycarboxylic acid polymer that is at least partially neutralized, and a non-ionic polymer, provided that, where said third polymeric material is a non-ionic polymer, said inner layer comprises at least one additive selected from a buffer agent and a base, said isolation layer comprising a non-ionic polymer which is soluble in intestinal fluid or gastrointestinal fluid, wherein the outer layer is applied directly to the inner layer or the isolation layer using a coating preparation formed by combining said first polymeric material in an aqueous medium with said second polymeric material in an organic medium.