Patent ID: 9527889
Filing Date: 2016-12-27
CPC Classification: A61K,A61P,C07K,C12Q,G01N

Claim Text:
1. An isolated peptide comprising the amino acid sequence of SEQ ID NO: 2 having (i) one or more amino acid substitutions at amino acid positions 1-11 of SEQ ID NO: 2 and/or (ii) an N-terminal truncation of no more than eight amino acids of SEQ ID NO: 2, wherein said peptide comprises an amino acid at position 9 of SEQ ID NO: 2 that is P or a modified version thereof; an amino acid at position 10 of SEQ ID NO: 2 that is L or Q or a modified version thereof; wherein the amino acid at position 5 of SEQ ID NO: 2, when present, is F or a modified version thereof; the amino acid at position 7 of SEQ ID NO: 2, when present, is N or a modified version thereof; wherein the amino acid at position 11 is not R; wherein said peptide comprises a modified amino acid at one or more amino acid positions 1-11 of SEQ ID NO: 2, said modified amino acid being a D-amino acid, or a chemical compound used as an alternative to an amino acid in synthesis of peptidomimetic compounds, an amino acid derivative, a synthetic amino acid, or a non-native amino acid, and said peptide modulates cardiac function in a vertebrate; or a salt, amide or ester thereof.