Patent ID: 9283301
Filing Date: 2016-03-15
CPC Classification: A61F,A61L

Claim Text:
1. A method for forming a hydrogel biomaterial comprising: combining collagen, soluble elastin, and at least one glycosaminoglycan to form a mixture; heating the mixture to form a gel; crosslinking the gel with a first crosslinking agent, the first crosslinking agent forming crosslinks between the collagen and the at least one glycosaminoglycan; crosslinking the gel with a second crosslinking agent, the second crosslinking agent stabilizing the soluble elastin; and degrading only a portion of the gel following crosslinking with the first and second crosslinking agents with one or more enzymes that target the at least one glycosaminoglycan to form the hydrogel biomaterial, the formed hydrogel, biomaterial exhibiting an equilibrium modulus of from about 3 kilopascals to about 10 kilopascals.