Patent ID: 9333179
Filing Date: 2016-05-10
CPC Classification: A61K,A61P,B82Y

Claim Text:
1. A nanoparticle comprising: a first covalent conjugate having the following formula: lipid—hydrophilic polymer—targeting moiety; a second covalent conjugate having the following formula: lipid—hydrophilic polymer; wherein the hydrophilic polymer of the first and second conjugates is a poly(ethylene glycol) polymer; a hydrophobic core comprising a polyester and an agent selected from the group consisting of a therapeutic agent, a diagnostic agent, and a prophylactic agent; an amphiphilic layer around the hydrophobic core, the layer comprising at least three amphiphilic components, wherein a first amphiphilic component of the layer is a phospholipid, and wherein a second amphiphilic component and a third amphiphilic component of the layer are the lipid portions of the first and second covalent conjugates; a hydrophilic outer layer comprising the hydrophilic polymer—targeting moiety portion of the first covalent conjugate and the hydrophilic polymer portion of the second covalent conjugate; wherein the weight ratio of the amphiphilic components of the amphiphilic layer to the polyester is about 0.05 to 0.34; and wherein the diameter of the nanoparticle is between about 40 and 500 nanometers.