Patent ID: 9296699
Filing Date: 2016-03-29
CPC Classification: A61P,C07D

Claim Text:
1. A process for preparing a 6-amino morphinan, the process comprising mixing dihydrosinomenine with an amine source comprising the formula R 6 NH 2 , wherein R 6 is selected from the group consisting of hydrogen, hydrocarbyl, and substituted hydrocarbyl, a hydrogen donor comprising a formate ion, a transition metal catalyst, and a proton acceptor, wherein the proton acceptor is chosen from ammonia, ammonium hydroxide, and sodium hydroxide; to produce the 6-amino morphinan, wherein at least one intermediate compound comprising a 6-imine moiety is produced during the process; and wherein the process avoids the use of hydrogen gas, and wherein the 6-amino morphinan product comprises an amount of the 6-alpha epimer less than 10%.