Patent ID: 9399630
Filing Date: 2016-07-26
CPC Classification: C07D

Claim Text:
1. A process for the preparation of a benzofuran-2-carboxamide derivative of formula I: or a pharmaceutically acceptable salt thereof, wherein R is H, a protecting group or an ‘IND-Q-’ radical, wherein IND is an indol-3-yl radical, a 2,3-di-hydro-1H-indol-3-yl radical, or a 2-oxo-2,3-di-hydro-1H-indol-3-yl radical, which is unsubstituted or mono- or polysubstituted by OH, OA, CN, X, COR Q is selected from —(CH A is an alkyl group having 1 to 6 carbon atoms; X is F, Cl, Br or I; R which comprises: amidation of a benzofuran-2-carboxylic acid ester derivative of formula II: or a salt thereof, wherein R is as defined in formula I, and R with ammonia in a suitable solvent to produce the benzofuran-2-carboxamide compound of formula I, and optionally converting the compound of formula I obtained into a pharmaceutically acceptable salt thereof, wherein the ammonia is used in the form of aqueous ammonia or ammonia gas or ammonia saturated in an organic solvent.