Patent ID: 9518117
Filing Date: 2016-12-13
CPC Classification: A61K,C07K

Claim Text:
1. A method of treating ischemia or ischemia-reperfusion injury in a patient in need thereof, comprising administering to said patient an effective amount of a monoclonal antibody, or antigen-binding fragment thereof, that specifically binds CD47, wherein said monoclonal antibody, or antigen-binding fragment thereof, comprises three light chain complementarity determining regions (LCDRs 1-3) and three heavy chain complementarity determining regions (HCDRs 1-3), wherein: LCDR 1 comprises the amino acid sequence RSSQSLVHSNGNTYLH (SEQ ID NO:1) LCDR 2 comprises the amino acid sequence KVSYRFS (SEQ ID NO:2); and LCDR 3 comprises the amino acid sequence SQNTHVPRT (SEQ ID NO:3); HCDR1 comprises the amino acid sequence (SEQ ID NO:4); HCDR 2 comprises the amino acid sequence DINPVNGDTNFNEKFKN (SEQ ID NO:5); and HCDR 3 comprises the amino acid sequence GGYTMDY (SEQ ID NO:6).