Patent ID: 9359421
Filing Date: 2016-06-07
CPC Classification: A61K,C07K

Claim Text:
1. A composition comprising an IFN-γ suppressor, wherein the IFN-γ suppressor has preserved affinity to an IFN-γ receptor, and wherein the IFN-γ suppressor has the amino acid sequence of SEQ ID NO: 5, wherein positions 86, 87 and 88 have been substituted with: His Val Cys (Construct No. 6), Thr Phe Trp (Construct No. 12), Leu Pro Phe (Construct No. 14), Ser Thr Phe (Construct No. 19), Ser Ser Leu (Construct No. 22), Ser Val Ser (Construct No. 26), Glu Met Pro (Construct No. 27), Leu Cys Pro (Construct No. 36), Thr Leu Leu (Construct No. 46-1), His Pro Leu (Construct No. 61), Phe Thr Arg (Construct No. 62), Arg Leu Arg (Construct No. 63), Ser Phe Phe (Construct No. 97), Phe Leu Val (Construct No. 108), Ser Leu Phe (Construct No. 123), Pro Pro Ser (Construct No. 133), Thr Asn Gly (Construct No. 134), Val Ser Pro (Construct No. 135), Cys Ala Pro (Construct No. 144), or Lys Lys Gln (Construct Lys/Gln88), or the IFN-γ suppressor has the amino acid sequence of SEQ ID NO:5 with positions 86-88 substituted with Lys Lys Gln and wherein the C-terminus is deleted (construct Lys/Gln88/T7).