Patent ID: 9296753
Filing Date: 2016-03-29
CPC Classification: A61J,A61K,A61P,B65D,C07B,C07D

Claim Text:
1. A crystalline Form A of 1-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one that has (a) an X-Ray powder diffraction (XRPD) pattern as shown in FIG. 1 and optionally at least one of the following properties: (a) an X-Ray powder diffraction (XRPD) pattern as shown in (b) an X-ray powder diffraction (XRPD) pattern with characteristic peaks at 5.7±0.1° 2-Theta, 13.6±0.1° 2-Theta, 16.1±0.1° 2-Theta, 18.9±0.1° 2-Theta, 21.3±0.1° 2-Theta, and 21.6±0.1° 2-Theta; (c) the same X-ray powder diffraction (XRPD) pattern post storage at 40° C. and 75% RH for at least a week; (d) the same X-ray powder diffraction (XRPD) pattern post storage at 25° C. and 97% RH for at least a week; (e) Infrared (IR) spectrum as the one set forth in (f) Infrared (IR) spectrum weak peaks at about 1584 cm (g) a DSC thermogram as the one set forth in (h) a thermo-gravimetric analysis (TGA) thermogram as the one set forth in (i) a DSC thermogram with an endotherm having an onset at about 154° C. and a peak at about 157° C. and an exotherm at about 159° C.; (j) non-hygroscopicity; (k) an observed aqueous solubility of about 0.013 mg/mL at about pH 8; or (l) combinations thereof.