Patent ID: 9475851
Filing Date: 2016-10-25
CPC Classification: A61P,C07K,C12N,C12Q,G01N

Claim Text:
1. Polypeptide, of at most 350 amino acids, comprising a cytoplasmic domain, wherein said cytoplasmic domain ends with a MAST-2 binding domain, wherein the size of said MAST-2 binding domain is from 11 to 13 amino acid residues, the first two residues of said MAST-2 binding domain are S and W, and the last four residues of said MAST-2 binding domain are Q, T, R and L, said MAST-2 binding domain being selected from the group consisting of: (A) a sequence, whose size is 11 residues, consisting of SWX (B) a sequence, whose size is 11 residues, selected from the group consisting of: SWX (C) a sequence, whose size is 12 residues, consisting of SWX (D) a sequence, whose size is 12 residues, selected from the group consisting of: SWX (E) a sequence, whose size is 13 residues, consisting of SWX wherein said polypeptide presents a binding affinity for the PDZ domain of the human MAST2 protein which is higher than the binding affinity of rabies virus G protein comprising the SWESHKSGGQTRL (SEQ ID NO:1) sequence for the PDZ domain of the MAST2 protein.