Patent ID: 9469728
Filing Date: 2016-10-18
CPC Classification: A61K,A61P,C08G,C08L

Claim Text:
1. A pH- and temperature-sensitive B-A-B block copolymer with excellent safety obtained by copolymerization of: (a) polyethylene glycol-based compound (A); and (b) poly (β-amino ester)-based oligomer (B), wherein the block copolymer is represented by the following formula: wherein k is a natural number ranging from 4 to 10, n is a natural number ranging from 11 to 45, and m is a natural number ranging from 10 to 100, wherein a molecular weight of the polyethylene glycol-based compound (A) is 500 to 8,000, wherein a molecular weight of the poly (β-amino ester)-based oligomer (B) is 1,000 to 5,000, wherein a molecular weight of the block copolymer is 3,000 to 32,000, wherein a molecular weight ratio of the polyethylene glycol-based compound (A) and the poly (β-amino ester)-based oligomer (B) is 1:1-4 wherein the block copolymer forms a hydrogel at pH 7.0 to 7.4 and a sol-state at pH 3.0 to under 7.0.