Patent ID: 9512092
Filing Date: 2016-12-06
CPC Classification: C07B,C07C,C07D,G01N

Claim Text:
1. A method of selectively activating chaperone-mediated autophagy (CMA) in a subject in need thereof comprising administering to the subject a compound of formula (II), or a combination of any compounds thereof, in an amount effective to activate CMA, wherein the subject has Parkinson's Disease, Huntington's Disease, frontotemporal dementia, retinal degeneration, multiple sclerosis, diabetes, a lysosomal storage disorder, a retinal disease, a cardiovascular disease, myocardial infarction, cardiac hypertrophy or a cardiomyopathy, and wherein formula (II) is wherein R1, R2, R3, R4, R5, R6, R8 and R9 of formula (II) are independently H, hydroxyl, halogen, SH, NO 2 , CF 3 , COOH, COOR10, CHO, CN, NH 2 , NHR10, NHCONH 2 , NHCONHR10, NHCOR10, NHSO 2 R10, OCR10, COR10, CH 2 R10, CON(R10,R11), CH═N—OR10, CH═NR10, OR10, SR10, SOR10, SO 2 R10, COOR10, CH 2 N(R10,R11), N(R10,R11), or optionally substituted lower alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalky, aryl, heteroaryl, aralkyl, or heteroaralkyl; wherein the optional substituent is one or more of F, Cl, Br, I, OH, SH, NO 2 , COOH, COOR10, R10, CHO, CN, NH 2 , NHR10, NHCONH 2 , NHCONHR10, NHCOR10, NHSO 2 R10, HOCR10, COR10, CH 2 R10, CON(R10, R11), CH═N—OR10, CH═NR10, OR10, SR10, SOR10, SO 2 R10, COOR10, CH 2 N(R10, R11), N(R10, R11); R7 of formula (II) is H, hydroxyl, halogen, CF 3 , CN, OCF 3 , COOH, COOCH 3 , COOR10, COO(CH 2 ) 2 Si(CH 3 ) 3 , COOR10Si(CH 3 ) 3 , NHCOCH 3 , C≡C—CH 2 OH, C≡C—R10-OH or optionally substituted alkyl, aryl, heteroaryl, aralkyl, heteroaralkyl, cyclic or heterocyclic; wherein the optional substituent is one or more of F, Cl, Br, I, OH, SH, NO 2 , CH 3 , R10, COOH, COOR10, CHO, CN, NH 2 , NHR10, NHCONH 2 , NHCONHR10, NHCOR10, NHSO 2 R10, HOCR10, COR10, CH 2 R10, CON(R10, R11), CH═N—OR10, CH═NR10, OR10, SR10, SOR10, SO 2 R10, COOR10, CH 2 N(R10, R11), N(R10, R11); R10 and R11 are independently H or C1-C6 alkyl; and X is O; and Y is N; or a pharmaceutically acceptable salt thereof.