Patent ID: 9289389
Filing Date: 2016-03-22
CPC Classification: A61K,A61P

Claim Text:
1. A method for producing a matrix-type pharmaceutical solid preparation comprising the following steps of: (a) wet-kneading a mixture comprising a methacrylic acid-based enteric polymer, a sugar and/or a sugar alcohol, and tolvaptan; and (b) extruding the wet-kneaded mixture obtained in step (a) toward a screen to produce cylindrical fibers; wherein the pharmaceutical solid preparation is free from a plasticizer, the tolvaptan is amorphous and in powder form, and the sugar and/or the sugar alcohol is at least one selected from the group consisting of erythritol, xylitol, lactitol, sorbitol, trehalose, maltose, dextrose, fructose and maltitol.