Patent ID: 9510767
Filing Date: 2016-12-06
CPC Classification: A61B,A61K,B03C

Claim Text:
1. A method for conducting an in situ measurement in a subject comprising providing at least two tracer solutions in a diagnostic panel; wherein each of the tracer solutions has a non-randomly sized distribution of a plurality of nanoparticles; wherein each of the non-randomly sized distributions corresponds to at least one first statistical parameter selected from the group consisting of a statistical mean size of the nanoparticles, a standard size deviation of the nanoparticles, a statistical size range of the nanoparticles, a particle diameter dispersity value of the nanoparticles, and a combination of at least two of the aforementioned statistical parameters; wherein a size of a nanoparticle is related to one of group of nanoparticle size measurements including an intrinsic core diameter, a hydrodynamic diameter, and a combination of an intrinsic core diameter and a hydrodynamic diameter; and wherein the nanoparticles are selected from a group of nanoparticle types consisting of non-magnetic nanoparticles, partially magnetic nanoparticles, magnetic nanoparticles, superparamagnetic nanoparticles, and a combination of at least two different nanoparticle types; introducing sequentially the at least two tracer solutions into the subject according to a selected order based upon the at least one first statistical parameter for a sequential introduction into a subject according to the selected order; conducting a non-invasive detection of each of the tracer solutions in the subject to determine at least one in situ measurement in the subject; wherein the in situ measurement is selected from the group of in situ measurements consisting of a size based ingestion rate of the nanoparticles by the subject, a size based mapping of locations of the nanoparticles in the subject, a size based take up rate of the nanoparticles by the subject, a size based flow rate of the nanoparticles through the subject, a retention rate of the nanoparticles by the subject, a progression profile of a size of a physical structure in the subject, a progression profile of a size of a defect in the subject, and a combination of two or more in situ measurements.