Patent ID: 9518127
Filing Date: 2016-12-13
CPC Classification: A61K,A61P,C07K,C12Y

Claim Text:
1. An anti-Factor XII/XIIa monoclonal antibody or antigen-binding fragment thereof comprising an immunoglobulin heavy chain variable (vH) region and an immunoglobulin light chain variable (vL) region, wherein the vH region comprises: a heavy chain CDR1 consisting of the sequence of SEQ ID NO: 6; a heavy chain CDR2 consisting of the sequence of GIX a heavy chain CDR3 consisting of the sequence of ALPRSGYLX wherein the vL region comprises: a light chain CDR1 consisting of the sequence set forth in any one of SEQ ID NOs: 11 and 44-51; a light chain CDR2 consisting of the sequence of SEQ ID NO: 12; and a light chain CDR3 consisting of the sequence of AX