Patent ID: 9459261
Filing Date: 2016-10-04
CPC Classification: A61P,G01N

Claim Text:
1. A method for evaluating renal status in a subject, comprising: performing one or more assays configured to detect Stromelysin-1:Metalloproteinase inhibitor 2 complex, on a body fluid sample obtained from the subject to provide an assay result; correlating the assay result(s) to the renal status of the subject by introducing the body fluid sample obtained from the subject into an assay instrument which contacts all or a portion of the body fluid sample with a binding reagent which specifically binds for detection Stromelysin-1:Metalloproteinase inhibitor 2 complex, and (ii) generates an assay result indicative of binding of Stromelysin-1:Metalloproteinase inhibitor 2 complex to the binding reagent; and correlating the assay result generated by the assay instrument to the renal status of the subject by using the assay result to assign the subject to a predetermined subpopulation of individuals having a known predisposition of a future acute renal injury within 72 hours of the time at which the body fluid sample is obtained; and treating the patient based on the predetermined subpopulation of individuals to which the patient is assigned, wherein the treatment comprises one or more of initiating renal replacement therapy, withdrawing delivery of compounds that are known to be damaging to the kidney, delaying or avoiding procedures that are known to be damaging to the kidney, and modifying diuretic administration.