Patent ID: 9453241
Filing Date: 2016-09-27
CPC Classification: A61K,A61P,C07K,C12N

Claim Text:
1. A nucleic acid molecule encoding a rhodopsin for differential expression in subcellular regions of a retinal ganglion cell (RGC), which molecule comprises: (a) a first nucleotide sequence encoding a light-gated channel rhodopsin or a light-driven ion pump rhodopsin; (b) linked in frame to (a), a second nucleotide sequence encoding a polypeptide sorting motif, wherein the sorting motif targets the center of said neuron's receptive field and wherein the nucleotide sequence encoding the sorting motif is: (c) operatively linked to (a) and (b), a transcriptional regulatory sequence; and (d) a polyadenylation sequence.