Patent ID: 9277737
Filing Date: 2016-03-08
CPC Classification: A01K,C12N

Claim Text:
1. A mouse or rat comprising cells containing a DNA QPCTL gene carrying a knock-out mutation, wherein (A) the mouse or rat carries at least one QPCTL allele where the QPCTL gene carries a Thymidine to Adenosine (T→A) nucleotide substitution at nucleotide position 442 of SEQ ID NO. 1, leading to the introduction of a stop codon into the QPCTL open reading frame; or (B) the QPCTL gene carries at least one mutation, results in the mutation of at least one amino residue that is responsible for complexation of the catalytic active zinc ion; and wherein the mutation in the QPCTL gene comprising SEQ ID NO: 2 or SEQ ID NO: 5 results in the mutation of at least one amino acid residue selected from the group consisting of Asp187, Glu227, and His352.