Patent ID: 9408871
Filing Date: 2016-08-09
CPC Classification: A01N,A61K,G01N

Claim Text:
1. A method for inhibiting complement activation, comprising administering an effective amount of an inorganic polyphosphate to a subject in need thereof, or by applying a polyphosphate to a surface of an organ or biomaterial, wherein the polyphosphate comprises at least 10 phosphate units and wherein the polyphosphate inhibits complement activation by one or more of: binding to the C6 complement protein, C1-esterase inhibitor (C1-inh), factor H or factor B; enhancing the activity of C1-inh; interfering with C1s-mediated cleavage of C2; destabilizing the C5b-6 complement protein complex; interfering with C5b,6 interaction with C7; interfering with binding of C5b-7 to a cell membrane; interfering with integration of C5b-7 into a cell membrane; interfering with binding of C5b-8 to a cell membrane; interfering with integration of C5b-8 into a cell membrane; destabilizing the membrane attack complex (MAC); or reducing the amount of C5b-9 deposited on a cell surface.