Patent ID: 9393220
Filing Date: 2016-07-19
CPC Classification: A61K,A61P,C07B,C07C,C07D

Claim Text:
1. A co-crystal comprising tramadol either as a free base or as a physiologically acceptable salt and at least one NSAID, wherein the NSAID is naproxen, its enantiomers or salts thereof, wherein the molecular ratio between the tramadol and naproxen is 1:2, and comprising (−)-tramadol either as a free base or as a physiologically acceptable salt and (S)-naproxen or comprising (+)-tramadol either as a free base or as a physiologically acceptable salt and (R)-naproxen, or mixture of enantiomers of these co-crystals, characterized in that it has a monoclinic unit cell with the following dimensions: a=9.512(2) Å b=40.5736(11) Å c=10.323(4) Å α=90° β=96.29(1)° γ=90°.