Patent ID: 9326971
Filing Date: 2016-05-03
CPC Classification: A61K,A61P

Claim Text:
1. A method for ameliorating a symptom of ethanol intolerance in a subject with reduced or absent aldehyde dehydrogenase subtype 2 (ALDH2) activity comprising orally administering to the subject about 0.1 mg to about 1.0 mg 4-methylpyrazole (4-MP) or a physiologically acceptable salt thereof per kilogram of the subject's body mass, wherein the subject is homozygous for alcohol dehydrogenase subtype 2*1 (ADH2*1/ADH2*1) or is heterozygous for alcohol dehydrogenase subtypes 2*1 and 2*2 (ADH2*1/ADH2*2).