Patent ID: 9265862
Filing Date: 2016-02-23
CPC Classification: A61L

Claim Text:
1. A method for ex vivo production of a three-dimensional bone implant adapted for implantation to a patient, the method comprising: disposing differentiated osteoblasts on a matrix support, wherein the matrix support comprises at least one material selected from the group consisting of collagen, calcium phosphate, tricalcium phosphate, and calcium sulfate; contacting said differentiated osteoblasts on said matrix support, to medium comprising autologous blood serum from the patient, wherein the autologous blood serum comprises at least one of a growth factor or a cytokine; disposing and incubating said differentiated osteoblasts on said matrix support and said medium within an ex vivo bioreactor, whereby a bone implant comprising bone tissue is produced within said ex vivo bioreactor; and shaping the bone implant prior to implantation to the patient to form the three dimensional bone tissue implant.