Patent ID: 9295758
Filing Date: 2016-03-29
CPC Classification: A61K,A61L

Claim Text:
1. An injectable graft composition for myocardial tissue regeneration, said composition comprising extracellular matrix (ECM) from a mammalian tissue source comprising acellular small intestine submucosa, said ECM comprising endogenous proteoglycans, transforming growth factor beta (TGF-β) and fibroblast growth factor-2 (FGF-2), said ECM further comprising an exogenously added vascular endothelial growth factor (VEGF) and cytokine, said VEGF component comprising greater than 0.1% by weight of said composition, said VEGF component being linked to a molecule in said ECM, wherein said VEGF component interacts with said proteoglycans to control matrix formation and remodeling, wherein, when said ECM composition is administered to damaged or diseased cardiovascular tissue, said ECM composition induces stem cell proliferation, differentiation of stem cells into cardiomyocytes and, thereby, angiogenesis.