Patent ID: 9433800
Filing Date: 2016-09-06
CPC Classification: A61K,A61N,A61P,B82Y,C12N

Claim Text:
1. A method for inducing the lysis or destruction of cancer cells, in vitro, ex vivo or in vivo, comprising (i) contacting cancer cells with one or more biocompatible composite particles or nanoparticle aggregates which can generate free radicals or heat when excited by X rays applied by using a system of radiotherapy or radiography, each of said biocompatible composite particle comprising a nucleus comprising a first inorganic compound that absorbs X rays and emits UV-visible energy, and said nucleus further comprising a second, inorganic or organic compound that absorbs said UV-visible energy and then produces said free radicals on contact with water or oxygen, said composite particle optionally additionally comprising a biocompatible coating allowing the diffusion of small molecules and free radicals, during a period of time sufficient to allow the particles or aggregates to penetrate inside the cancer cells and, (ii) exposing the cells to X rays, said exposure inducing the lysis or destruction of said cancer cells.