Patent ID: 9334497
Filing Date: 2016-05-10
CPC Classification: A61P,C12N,C12Q

Claim Text:
1. A method for inhibiting RNA silencing of a gene, comprising, contacting a cell or organism containing an siRNA or a mature miRNA that directs RNA silencing of the gene, with a single-stranded, nuclease resistant RNA oligonucleotide RISC inactivator, wherein the RISC inactivator comprises a nucleotide sequence sufficiently complementary to a guide strand sequence of the siRNA or the nucleotide sequence of the miRNA, to inhibit RNA silencing of the gene by the siRNA or the miRNA, and wherein the RISC inactivator is a stoichiometric, irreversible inhibitor of RISC function, such that RNA silencing of the gene is inhibited.