Patent ID: 9279814
Filing Date: 2016-03-08
CPC Classification: B01L,C07H,C12Q,G01N,Y10T

Claim Text:
1. A method for structural mapping a macromolecule in an aqueous solution comprising: (a) contacting the aqueous solution containing the macromolecule with a persulfide of a persulfide-lined chamber such that hydroxyl radicals are generated; (b) incubating the aqueous solution containing the macromolecule such that the macromolecule is (i) cleaved by the hydroxyl radicals, thereby producing cleaved macromolecule fragments or (ii) oxidized by the hydroxyl radicals, thereby producing macromolecules of altered molecular weight; and (c) analyzing the cleaved macromolecule fragments or macromolecules of altered molecular weight produced in step (b) via a structural genomics method, thereby structural mapping the macromolecule.