Patent ID: 9446169
Filing Date: 2016-09-20
CPC Classification: A61L,C12M,C12N

Claim Text:
1. A device for creating perfusable vessels in vitro comprising: a device body including a silicone layer sandwiched between a first layer and a second layer; a plurality of fluid ports embedded in the silicone layer; a plurality of port connecting channels embedded in the silicone layer; at least one cell reservoir port embedded in the silicone layer, the cell reservoir port being connected by a first port connecting channel to an inlet port and connected by a second port connecting channel to an outlet port; a matrix chamber containing collagen embedded in the silicone layer, the matrix chamber having one or more perfusion channels formed in the collagen; a plurality of non-permeable capillary tubes each coupled at one end to one or more of the plurality of fluid ports and having a second end; wherein only the second end of each non-permeable capillary tube reaches into the matrix chamber; and wherein the first end of each non-permeable capillary tube is located to be pulled back into the at least one cell reservoir port.