Patent ID: 9272022
Filing Date: 2016-03-01
CPC Classification: A61K,A61P,C07H,C07K,C12N,C12Q,G01N

Claim Text:
1. A method of inhibiting stress granule formation in a subject comprising administering to said subject a therapeutically effective amount of one or more poly-ADP-ribose polymerase (PARP)12 inhibitor(s) and/or one or more PARP13 inhibitor(s) wherein: (a) said one or more PARP12 inhibitor(s) is (i) an antibody or an antibody fragment that selectively binds PARP12, or (ii) an RNA aptamer comprising the sequence of any one of SEQ ID NOs: 99-106; and/or (b) said one or more PARP13 inhibitor(s) is (i) an antibody or an antibody fragment that selectively binds PARP13.1 and/or PARP13.2, or (ii) an RNA aptamer comprising the sequence of any one of SEQ ID NOs: 40 and 107-113, and wherein said administering results in the inhibition of stress granule formation in said subject.