Patent ID: 9347079
Filing Date: 2016-05-24
CPC Classification: C12N,C12P,C12R

Claim Text:
1. A process for the manufacture of sodium hyaluronate with defined molecular weight ranging from 60 to 2400 kDa and a polydispersity of 1.4 M w /M n which comprises: a) a fermentation step of b) an ultrafiltration step of the cell-free filtered solution with membranes of polyethersulfone or polypropylene with a cut-off of 10-100 kDa, concentrating and diafiltering the solution in differential pressure conditions (ΔP) from 1.0 to 5.0 bar(g) and at transmembrane pressure (TMP) from 0.5 to 4.5 bar(g); and c) a heat treatment step in a temperature range of between 50° C. to 65° C.