Patent ID: 9365651
Filing Date: 2016-06-14
CPC Classification: A61K,A61P,C07K

Claim Text:
1. A method of treating a metabolic disorder in a subject, comprising administering an anti-ActRIIB antibody to a subject in need thereof, wherein the anti-ActRIIB antibody increases brown adipose tissue in the subject without increasing red blood cell levels in said subject, wherein the anti-ActRIIB antibody comprises a heavy chain variable region (V H ) CDR1 comprising the amino acid sequence set forth as SEQ ID NO:9; a V H CDR2 comprising the amino acid sequence set forth as SEQ ID NO:23; a V H CDR3 comprising the amino acid sequence set forth as SEQ ID NO:37; a light chain variable region (V L ) CDR1 comprising the amino acid sequence set forth as SEQ ID NO:51; a V L CDR2 comprising the amino acid sequence set forth as SEQ ID NO:65; and a V L CDR3 comprising the amino acid sequence set forth as SEQ ID NO:79.