Patent ID: 9388231
Filing Date: 2016-07-12
CPC Classification: A61P,C07K

Claim Text:
1. A heteromultimer comprising: a first polypeptide construct that comprises (i) a first transporter polypeptide; and a second polypeptide construct that comprises (ii) a second transporter polypeptide; wherein each of said first and second transporter polypeptide comprises an amino acid sequence comprising a segment of an albumin polypeptide selected from native human serum albumin polypeptide and human alloalbumin polypeptide; wherein said first and second transporter polypeptides are obtained by segmentation of said albumin polypeptide at a segmentation site, such that the segmentation results in a deletion of zero to 3 amino acid residues at the segmentation site; wherein said first transporter polypeptide comprises at least one mutation selected from A194C, L198C, W214C, A217C, L331C and A335C, and said second transporter polypeptide comprises at least one mutation selected from L331C, A335C, V343C, L346C, A350C, V455C, and N458C; and wherein said transporter polypeptides self-assemble to form a quasi-native structure of the monomeric form of the albumin polypeptide.