Patent ID: 9448223
Filing Date: 2016-09-20
CPC Classification: B01L,C12M,G01N

Claim Text:
1. A digital microfluidic device comprising: a first plate comprising: a second plate comprising: wherein said second plate is provided in a spaced relationship relative to said first plate, such that a droplet contacting said first plate and said second plate is transportable among locations associated with said discrete electrodes under application of a suitable bias between said discrete electrodes and said reference electrode; wherein at least one of said first plate and said second plate comprises a locally hydrophilic surface region that is proximal to a pre-selected discrete electrode of said array of discrete electrodes, wherein said locally hydrophilic surface region is configured for attachment of adherent cells; and wherein at least one of said first plate and said second plate further comprises a dedicated sensing electrode that is proximal to said locally hydrophilic surface region; wherein a droplet is transportable to said locally hydrophilic surface region based on the application of a voltage between said array of discrete electrodes and said reference electrode in the absence of actuation of said dedicated sensing electrode, and wherein an electrical signal associated with an impedance of adherent cells attached to said locally hydrophilic surface region is measurable based on another voltage applied between said dedicated sensing electrode and one of said pre-selected discrete electrode and said reference electrode.