Patent ID: 9409992
Filing Date: 2016-08-09
CPC Classification: A61K,C07K,G01N

Claim Text:
1. An isolated monoclonal antibody that binds mesothelin, wherein: (i) the variable heavy (VH) domain of the antibody comprises a complementarity determining region (CDR) (ii) the VH domain of the antibody comprises a CDR1 set forth as amino acid residues 27-34 of SEQ ID NO: 9, a CDR2 set forth as amino acid residues 52-59 of SEQ ID NO: 9 and a CDR3 set forth as amino acid residues 98-111 of SEQ ID NO: 9; and the VL domain of the antibody comprises a CDR1 set forth as amino acid residues 27-32 of SEQ ID NO: 11, a CDR2 set forth as amino acid residues 50-52 of SEQ ID NO: 11 and a CDR3 set forth as amino acid residues 89-100 of SEQ ID NO: 11; (iii) the VH domain of the antibody comprises a CDR1 set forth as amino acid residues 26-33 of SEQ ID NO: 17, a CDR2 set forth as amino acid residues 51-58 of SEQ ID NO: 17 and a CDR3 set forth as amino acid residues 97-108 of SEQ ID NO: 17; and the VL domain of the antibody comprises a CDR1 set forth as amino acid residues 27-32 of SEQ ID NO: 19, a CDR2 set forth as amino acid residues 50-52 of SEQ ID NO: 19 and a CDR3 set forth as amino acid residues 89-100 of SEQ ID NO: 19; (iv) the VH domain of the antibody comprises a CDR1 set forth as amino acid residues 25-33 of SEQ ID NO: 21, a CDR2 set forth as amino acid residues 51-57 of SEQ ID NO: 21 and a CDR3 set forth as amino acid residues 96-113 of SEQ ID NO: 21, or comprises a CDR1 set forth as amino acid residues 26-34 of SEQ ID NO: 29, a CDR2 set forth as amino acid residues 52-60 of SEQ ID NO: 29 and a CDR3 set forth as amino acid residues 98-112 of SEQ ID NO: 29; and the VL domain of the antibody comprises a CDR1 set forth as amino acid residues 27-32 of SEQ ID NO: 23, a CDR2 set forth as amino acid residues 50-52 of SEQ ID NO: 23 and a CDR3 set forth as amino add residues 89-100 of SEQ ID NO: 23; or (v) the VH domain of the antibody comprises a CDR1 set forth as amino acid residues 25-33 of SEQ ID NO: 25, a CDR2 set forth as amino acid residues 51-59 of SEQ ID NO: 25 and a CDR3 set forth as amino acid residues 97-109 of SEQ ID NO: 25; and the VL domain of the antibody comprises a CDR1 set forth as amino acid residues 27-32 of SEQ ID NO: 27, a CDR2 set forth as amino acid residues 50-52 of SEQ ID NO: 27 and a CDR3 set forth as amino acid residues 89-102 of SEQ ID NO: 27.