Patent ID: 9314524
Filing Date: 2016-04-19
CPC Classification: A61K

Claim Text:
1. A topical composition for exterior treatment of vulvovaginal candidiasis comprised of flucytosine, a carrier, and poly(lactic acid), wherein the flucytosine is selected from the group consisting of flucytosine, a flucytosine salt or a mixture thereof and is capable of forming ionized flucytosine; wherein the poly(lactic acid) reduces permeation of flucytosine across skin and mucosal membrane; wherein the carrier comprises a pH modulator suitable to establish a pH of the composition of between about 1 to about 5 to control the ratio of ionized flucytosine to unionized flucytosine within the composition and wherein the topical composition is configured to minimize systemic absorption of the ionized flucytosine in the treatment environment.