Patent ID: 9364549
Filing Date: 2016-06-14
CPC Classification: A61K,A61P,C07K

Claim Text:
1. A method for manufacturing a sustained release drug-delivery composition, comprising: providing at least a pharmaceutically active composition dissolved in an aqueous solution; providing a hydrophobic matrix comprising at least a hydrophobic solid component and a hydrophobic liquid component, wherein the hydrophobic matrix is formed by mechanical treatment of the hydrophobic solid component and the hydrophobic liquid component, said mechanical treatment comprising repeated pressing and folding, wherein the hydrophobic matrix is kept in a non-molten state throughout the mechanical treatment; mixing the hydrophobic matrix and the pharmaceutically active composition dissolved in an aqueous solution to form a paste-like or semi-solid drug-delivery composition, said mixing comprising repeated pressing and folding of the hydrophobic matrix and the pharmaceutically active composition to form the paste-like or semi-solid drug-delivery composition, wherein the pressing applies a pressure of not more than 10 wherein the pharmaceutically active composition dissolved in an aqueous solution comprises a pharmaceutically active compound selected from the group consisting of humanized monoclonal antibodies and human monoclonal antibodies.