Patent ID: 9441262
Filing Date: 2016-09-13
CPC Classification: A61K,C07K,C12Q

Claim Text:
1. A method of identifying an inhibitor of MASP-2 that is capable of inhibiting MASP-2 activity comprising assessing MASP-2 activity in the presence of a candidate inhibitor wherein said inhibitor of MASP-2 activity is (1) an antibody which specifically binds to MASP-2 or an antibody fragment which specifically binds to MASP-2, (2) a serine protease inhibitor, or (3) a polypeptide fragment of MASP-2, wherein said method comprises (a) isolating free MASP-2 not associated with MBL, (b) incubating said free MASP-2 in the presence of said candidate inhibitor, (c) adding MBL and measuring MASP-2 mediated MBLectin complement pathway activation in an in vitro assay where MASP-2 is present as part of an MBL/MASP complex.