Patent ID: 9335331
Filing Date: 2016-05-10
CPC Classification: G01N

Claim Text:
1. A method comprising: providing one or more cerebrospinal fluid test samples from a subject comprising at least 8 proteins selected from albumin, alpha-1-antitrypsin, apolipoprotein E, apolipoprotein J, complement component 3, contactin, fibrin beta, Ig heavy chain, Ig light chain, neuronal pentraxin receptor, plasminogen, proSAAS, retinol-binding protein, transthyretin, and vitamin D binding protein; contacting the one or more cerebrospinal fluid test samples with reagents selected from the group consisting of antibodies, aptamers, and combinations thereof specific to each of the at least 8 proteins to form at least 8 different protein-reagent complexes; detecting the at least 8 different protein-reagent complexes; and quantifying the relative levels of each of the at least 8 proteins in the test sample(s) based on detection of the at least 8 different protein-reagent complexes.