Patent ID: 9229003
Filing Date: 2016-01-05
CPC Classification: A61P,C12Q,G01N

Claim Text:
1. A method for detecting an increased risk of anaplastic thyroid carcinoma in a human, which comprises: a) detecting mRNA of an itchy homolog E3 ubiquitin protein ligase (ITCH) gene in a thyroid biopsy sample from the human by performing an RT-PCR method using primers consisting of SEQ ID NO: 17 and 18 and determining an increased level of mRNA in the sample as compared with a non-anaplastic thyroid carcinoma sample from a human; b) detecting protein expression of an ITCH gene in the sample by performing an immunohistochemical method; and c) determining an increase risk of anaplastic thyroid carcinoma in the human when an increased level of mRNA and protein expression is detected.