Patent ID: 9295731
Filing Date: 2016-03-29
CPC Classification: A61K,Y02A

Claim Text:
1. A compound of Formula (II): or a salt thereof, wherein: each A wherein: each X each X each R D is selected from aminopterin, folitixorin. methotrexate, pemetrexed, ralatrexate, raltitrexed, pelitrexol, talotrexin. deoxycoformycin, cladribine, clofarabine, fludarabine, thioguanine, mercaptopurine, berubicin daunorubicin, doxorubicin, epirubicin, idarubicin, amrubicin, pirarubicin, zorubicin mitoxantrone, banoxantrone, ledoxantrone, nortoixantrone, pixantrone, piroxantrone, sabarubicin, topixantrone, monomethyl, auristatin E, monomethyl, auristatin F, monomethyl, dolastatin, 10, dolastatin 15, belotecan, atiratecan, camptopthecin, exatecan, irinotecan, namitecan, rubitecan, topotecan, demecolcine, duocarmycin A, duocarmycin SA, duocarmycin B, duocarmycin B1 ,abbeymycin, anthramycin, centanamycin, chicamycin, mazethramycin, porothrarnycin A, porothramycin B, sibanomycin, sibiromycm, trabectedin, calicheamicin γ1, calicheamicin T, esperamicin Al, esperamicin C, esperamicin D, dynemicin A, dynemicin H, dynemicin M, dynemicin N, dynemicin O, dynemicin p, dynemicin Q, dynemicin S, neocarzinostatin chromophore, uncialamycin, 21-aminoepothilone B, eribulin, hemiasterlin, HTI-286, kahalatide F, elsamitrucin, lucanthone, melphalan, mitoguazone, nimustine, procarbazine, dacarbazine, amsacrine 5-amino-4-oxo-pentanoic acid. methyl 5-amino-4-oxo -pentanoate, actimomycin D, 7-aminoactinomycin D, bleomycin, mitomycin, staurosporine, desacetylvinblastine hydrazide, vinblastine, vincristine, vindesine, vinflunine, vinorelbine, afatinib, apilimbd, balamanimod, barasertib, bosutinib, ceanertinib, cevipabulin, crizotinib, dacomitinib, dasatinib, denibulin. dilmapimod, dinaciclib, dovitiriib, dutacatib, duvoglustat, edotecarin, elisidepsin, entinostat, epetirimod, erlotinib, fingolimod, fostamatinib, gefitinib, golotimod, gusperimus, imatinib, imiquimod, intedanib, ispinesib, lapatinib, lenalidomide, linifanib, litronesib, losmapimod, metesind, mocetinostat, motesanib, masitinib, myriocin, neratinib, nilotinib, odanacatib, ombrabulin, pamapimod, panobinostat, pazopanib, plerixafor, pomalidomide, razupenem, resiquimod, sabarubicin, saracatinib, seliciclib, selumetinib, sotirimod, squalamine, tacedinaline, talabostat, taltobulin, telatinib, tipifarnib, tozasertib, vandetanib, vatalanib, veliparib, voreloxin, alvespimycin, amikacin, amphotericin B, arbekacin, astromicin, bacitracin, balofloxacin, bederocin, bekanamycin, besifloxacin, brodimoprim, ciprofloxacin, clinafloxacin, colistin, daptomycin, dibekacin, enoxacin, framycetin, garenoxacin, gatifloxacin, gemifloxacin, gentamicin, gentamicin, grepafloxacin, hamycin, hexetidine, hygromycin B, ibacitabine, iclaprim, isepamicin, kanamycin, lomefloxacin, lucimycin, lymecycline, mepartricin, moxifloxacin, natamycin, nemonoxacin, neomycin B, neomycin C, netilmicin, norfloxacin, nystatin, omadacycline, oritavancin, paromomycin, pazufloxacin, perimycin A, perimycin B, perimycin C, pipemidic acid, polymyxin B, puromycin, radezolid, retaspimycin, ribostamycin, rimocidin, sisomicin, sitafloxacin, sparfloxacin, spectinomycin, streptomycin, sulfacetamide, sulfadiazine, sulfadimethoxine, sulfadimidine, sulfafurazole, sulfalene, sulfamazone, sulfamerazine, sulfamethizole, sulfamethoxazole, sulfamethoxypyridazine, sulfametomidine, sulfametoxydiazine, sulfametrole, sulfamoxole, sulfanilamide, sulfaperin, sulfaphenazole, sulfapyridine, sulfathiazole, sulfathiourea, sulfisomidine, teicoplanin, telavancin, tanespimycin, temafloxacin, tetroxoprim, tigecycline, tobramycin, tosufloxacin, trimethoprim, trimethoprim, trovafloxacin, tyrothricin, ulifloxacin, valnemulin, vancomycin, verdamicin, and zabofloxacin; and n5 is an interger selected from 1to 20.