Patent ID: 9511134
Filing Date: 2016-12-06
CPC Classification: A61K,A61P,C07K,C12N

Claim Text:
1. An isolated immunogenic polynucleotide comprising: (a) a nucleic acid encoding one to ten influenza HTL epitopes selected from the group of epitopes as set forth in Table 4; (b) a nucleic acid encoding a pan-DR binding epitope; (c) a nucleic acid encoding an influenza matrix protein 2 external (M2e) sequence selected from the sequences set forth in Table 6; (d) a nucleic acid sequence encoding a polypeptide at least 90% identical to an influenza hemagglutinin (HA) sequence, or fragment thereof; and (e) wherein the nucleic acid of (b) is located 5′ to the nucleic acid of (d); and wherein the polynucleotide enhances an immune response to influenza virus infection.