Patent ID: 9486513
Filing Date: 2016-11-08
CPC Classification: A61K,C07K,C12N,Y02A

Claim Text:
1. A genetically engineered bacterium which will a virulently replicate within a mammal infected by at least one organism selected from the group consisting of a parasitic worm, an insect, and a pathogenic amoeba, after administration of the genetically engineered bacterium thereto, comprising: a first genetically engineered construct that causes the bacterium within the mammal to produce, in a toxic form, a protein encoded by the first genetically engineered construct which is toxic to the at least one organism; and a second genetically engineered construct that causes the genetically engineered bacterium within the mammal to produce at least one heterologous protease inhibitor encoded by the second genetically engineered construct, wherein the at least one heterologous protease inhibitor is effective to reduce degradation of the protein encoded by the first genetically engineered construct which is toxic to at least one organism by a protease present in the at least one organism.