Patent ID: 9375481
Filing Date: 2016-06-28
CPC Classification: A61J,A61K,A61P,B82Y,C07C,Y10S

Claim Text:
1. A method of preparing a plurality of therapeutic nanoparticles, comprising: combining a therapeutic agent, a first polymer bound to a ligand, and a second polymer, with an organic solvent to form a first organic phase having about 5 to about 50% solids; combining the first organic phase with a first aqueous solution to form a second phase; emulsifying the second phase to form an emulsion phase; quenching the emulsion phase to form a quenched phase; adding a drug solubilizer to the quenched phase to form a solubilized phase of unencapsulated therapeutic agent; filtering the solubilized phase using a tangential flow filtration system; and sterile filtering the solubilized phase to recover the therapeutic nanoparticles, thereby forming a slurry of therapeutic nanoparticles having a diameter of about 80 nm to about 150 nm.