Patent ID: 9394526
Filing Date: 2016-07-19
CPC Classification: A61K,A61P,C07K,C12N

Claim Text:
1. A method of treating a patient having a disease or disorder associated with hypoxia or ischemia, comprising directly administering to the patient a composition comprising a conditionally silenced vector comprising: at least one FROG element, at least one TOAD element, at least one hypoxia response element (HRE), a gene encoding at least one growth factor, and a promoter upstream of the gene that is in operable linkage with the gene, the at least one FROG element, the at least one TOAD element, and the at least one HRE, in a therapeutically effective controlled amount for inhibiting necrosis and increasing blood flow in ischemic or hypoxic tissue or organ, wherein the growth factor is not expressed in aerobic tissue but is expressed in the ischemic or hypoxic tissue, wherein the at least one FROG element consists of a nucleotide sequence selected from the group consisting of: SEQ ID NOS: 3 and 4, and the at least one TOAD element consists of a nucleotide sequence selected from the group consisting of: SEQ ID NOS: 1 and 2.