Patent ID: 9459189
Filing Date: 2016-10-04
CPC Classification: B01L,G01N

Claim Text:
1. A device for isolating a fraction in a biological sample, the fraction being bound to solid phase substrate to define a fraction-bound solid phase substrate, comprising: an input zone for receiving the biological sample therein, the input zone partially defined by first and second spaced end walls and a lower surface therebetween; an isolation zone for receiving an isolation fluid therein, the biological sample and the isolation fluid having an interface with a surface tension; a passage having an input communicating with the input zone and an output communicating with the isolation zone, the input of the passage partially defined by an upper wall and a lower wall intersecting the second end wall of the input zone at an edge lying in a horizontal plane vertically spaced from the lower surface of the input zone such that a portion of the input zone lies between the horizontal plane and lower surface of the input zone; and a force generator configured to generate a force working against gravity, the force being movable by the force generator between a first position adjacent the input zone and a second position adjacent the isolation zone; wherein: the surface tension of the interface retaining the biological sample in the input zone and the isolation fluid in the isolation zone; the force captures the fraction-bound solid phase substrate and suspends the fraction-bound solid phase substrate within the input zone with the force in the first position; and the fraction-bound solid phase substrate moves from the input zone to the isolation zone in response to the force moving from the first position to the second position.