Patent ID: 9481651
Filing Date: 2016-11-01
CPC Classification: C07D

Claim Text:
1. A biphasic process for the preparation of the compound of Formula A comprising the steps of: a) creating a first mixture by combining together a 2-phase water-organic solvent system, an ammonia source, a cyanide source and a furan-2-aldehyde of Formula B b) separating a second mixture from the first mixture which includes the compound of Formula C as a solution in the organic solvent; c) adding an aqueous solution of a mineral acid to the second mixture to form a third mixture; d) separating a fourth mixture from the third mixture which is an aqueous mixture that includes the compound of formula D; wherein X is Br, HSO 4 , NO 3 or H 2 PO 4 ; e) adding a brominating agent to the fourth mixture to form a fifth mixture; and f) isolating the compound of Formula A from the fifth mixture.