Patent ID: 9365493
Filing Date: 2016-06-14
CPC Classification: A61P,C07C,C07D

Claim Text:
1. A method of synthesizing a compound of formula: or salt, isomer, or tautomer thereof; wherein: R R R R R each occurrence of R n is 0 or an integer in the range of 1 to 3, inclusive; the method comprising: reacting an anion of a toluate, wherein the toluate is of formula: wherein the anion is formed by deprotonation of a toluate under basic conditions, and wherein: R P is hydrogen, lower (C with an enone of formula: or a salt, isomer, or tautomer thereof; wherein: R each P′ is independently hydrogen or a protecting group; to provide a compound of formula: or a salt, isomer, or tautomer thereof.