Patent ID: 9354223
Filing Date: 2016-05-31
CPC Classification: A61P,G01N

Claim Text:
1. A method for determining the likelihood of a living patient having Alzheimer's disease pathology (AD pathology) comprising the steps of a) determining the amount of one or more of a protein-protein complex i) α7nAChR/FLNA, ii) TLR4/FLNA and iii) α7nAChR/Aβ present in a first portion of a lymphocyte preparation from said living patient; b) determining the amount of said one or more of i) α7nAChR /FLNA, ii) TLR4/FLNA and iii) α7nAChR/Aβ present as a protein-protein complex in a second portion of said lymphocyte preparation, said second portion of said lymphocyte portion further containing admixed therein a FLNA binding-effective amount of a compound that binds to a pentapeptide of filamin A (FLNA) of SEQ ID NO: 1, or a pharmaceutically acceptable salt said compound; and c) comparing the values so determined, whereby a determined amount of said one or more of i) α7nAChR /FLNA, ii) TLR4/FLNA and iii) α7nAChR/Aβ present as a protein-protein complex in a second portion of said lymphocyte preparation that is significantly decreased in the presence of said compound or said pharmaceutically acceptable salt of said compound indicates that the patient had AD pathology at the time the body sample was taken, whereas no significant difference between the two determined values indicates that the patient was free of AD pathology at the time the body sample was taken; wherein said compound is a compound of Series C-2 that corresponds in structure to the Formula A below: wherein Q is CHR each of m and n is zero or one and the sum of m+n is 1 or 2; each of G, P and W is selected from the group consisting of NR each of d, e, f and k is either zero or one and the sum of (d+e+f+k)=2; D and F are the same or different and are CH or CD; E and K are the same or different and are CH X is SO circle A is an aromatic or heteroaromatic ring system that contains a single ring or two fused rings; R wherein the amido nitrogen in either amide group has the formula NR MAr, where M is —CH 2 —, —O— or —N═N—and Ar is a single-ringed aryl or heteroaryl group and NR 5 R 6 wherein R R R