Patent ID: 9393244
Filing Date: 2016-07-19
CPC Classification: A61K

Claim Text:
1. A method of promoting parkin activity in a subject that has a neurodegenerative disease of the central nervous system, a myodegenerative disease or a prion disease, comprising: a) selecting a subject with a disorder associated with decreased parkin activity, wherein the disorder is a neurodegenerative disease of the central nervous system, a myodegenerative disease or a prion disease, wherein the neurodegenerative disease is selected from the group consisting of Amyotrophic Lateral Sclerosis, Alzheimer's Disease, Parkinson's Disease, Huntington's Disease, and Mild Cognitive Impairment, an α-Synucleinopathy and a Tauopathy; and b) administering to the subject an effective amount of a composition that increases parkin activity, wherein the composition is an inhibitor of a deubiquitinating enzyme.