Patent ID: 9457056
Filing Date: 2016-10-04
CPC Classification: A61K,A61P,C07K

Claim Text:
1. A method for treatment of progression of osteoporosis or pre-osteoporotic condition comprising promoting biomineralization to treat such condition in a patient in need thereof, by direct administration involving injection or implantation of a therapeutically effective amount of a biodegradable hydrogel composition comprising a hydrogel formed by at least one amphiphilic peptide, derivative or salt thereof that forms a β-sheet structure that promotes biomineralization, wherein said biodegradable hydrogel composition is capable of attracting and sustaining calcium ions and wherein the at least one amphiphilic peptide consists of an amino acid sequence of: X-(Phe-Glu) X-(Phe-Asp) X-(Leu-Glu) X-(Leu-Asp) wherein n designates an integer of 2-9, X designates Pro, Pro-hydrophilic or represents the amino terminus of Phe or Leu, and B is Pro or represents the carboxy terminus of Glu or Asp, and wherein hydrophilic designates an amino acid residue selected from the group consisting of: Glu and Asp.