Patent ID: 9402868
Filing Date: 2016-08-02
CPC Classification: A61K,A61L,A61P

Claim Text:
1. A method for preparing a nerve graft for implantation into a mammal, the method comprising the steps of: a) providing a nerve graft capable of supporting axonal ingress after implantation and comprising a structurally complete nerve segment containing an intact basal lamina tube; b) rendering the nerve graft acellular by chemical extraction with a detergent; c) degrading chondroitin sulfate proteoglycan of the nerve graft by applying, in vitro, at least one chondroitin sulfate proteoglycan-degrading enzyme to the nerve graft so as to condition the nerve graft for enhanced post-implantation axonal ingress from a truncated adult peripheral nerve of the mammal into the nerve graft at a site of coaptation wherein the post-implantation axonal ingress is enhanced relative to a nerve graft to which the at least one chondroitin sulfate proteoglycan-degrading enzyme has not been applied.