Patent ID: 9412006
Filing Date: 2016-08-09
CPC Classification: G01N,G06K,G06T

Claim Text:
1. A method for the assessment of biomarker expressions in tissue analysis, comprising: detecting a plurality of cells within a digital image of a tissue section using a computerized system programmed for digital analysis of microscopy images; detecting one or more features for each cell of the plurality of cells, said features including staining associated with a cell membrane; classifying each of said detected cells into one of a plurality of cell classifications based on said detected features; counting an amount of detected cells for each of said cell classifications; calculating the percentage of the plurality of cells for each cell classification; determining a discrete score for the digital image, wherein said discrete score is based on the percentage of the plurality of cells for each cell classification and a threshold value associated with each of the cell classifications; the method further comprising: applying an algorithm configured to calculate a continuous score; wherein said continuous score comprises a combination of the discrete score for the digital image and one of: a distance to a next highest discrete score, a confidence of the discrete score, or a combination thereof; and representing the continuous score corresponding to the digital image.