Patent ID: 9522144
Filing Date: 2016-12-20
CPC Classification: A61K,A61P

Claim Text:
1. A method of inhibiting development of diabetes, comprising: identifying a subject in need of enhanced levels of adiponectin, wherein the subject does not have diabetes; and administering to the subject an amount of nitroxide antioxidant effective to increase proliferation of pancreatic beta cells, ameliorate insulin resistance, increase intracellular levels of adiponectin or to increase expression of an adiponectin gene in the subject, thereby inhibiting development of diabetes, wherein the nitroxide antioxidant is selected from the following formulas: wherein X is selected from O— and OH, and R is selected from COOH, CONH 2 , CN, and CH 2 NH 2 ; wherein X is selected from O— and OH, and R 1 is CH 3 , R 2 is C 2 H 5 , or R 1 and R 2 taken together are spirocyclohexyl; wherein X is selected from O— and OH and R is selected from CONH 2 ; and wherein X is selected from O— and OH and R is selected from H, OH, and NH