Patent ID: 9284372
Filing Date: 2016-03-15
CPC Classification: A61K,A61P,C07K

Claim Text:
1. An isolated antibody or antigen binding fragment thereof comprising a. a light chain variable domain comprising: i. a light chain CDR1 sequence comprising the amino acid sequence of SEQ ID NO:13; ii. a light chain CDR2 sequence comprising the amino acid sequence of SEQ ID NO:60; and iii. a light chain CDR3 sequence comprising the amino acid sequence of SEQ ID NO:105; and b. a heavy chain variable domain comprising: i. a heavy chain CDR1 sequence comprising the amino acid sequence of SEQ ID NO:145; ii. a heavy chain CDR2 sequence comprising the amino acid sequence of SEQ ID NO:173, and iii. a heavy chain CDR3 sequence comprising the amino acid sequence of SEQ ID NO:212; wherein the antibody or antigen binding fragment thereof binds a wild-type TSLP polypeptide consisting of amino acids 29-159 as set forth in SEQ ID NO: 2 with a greater affinity than the antibody or antigen binding fragment thereof binds to a mutated TSLP polypeptide consisting of amino acids 29-159 as set forth in SEQ ID NO: 2 but comprising a serine to arginine mutation at position 40 (S40R).