Patent ID: 9290526
Filing Date: 2016-03-22
CPC Classification: C07F

Claim Text:
1. A method for treating osteoporosis, tumor-induced hypercalcemia, Paget's disease, osteolytic metastases; regulating the proliferation, invasive properties, and pro-angiogenic activity in human cancers; stimulating the immune system; reducing neuronal damage and the progression of Alzheimer's disease (AD) or lowering of cholesterol; comprising administering to a patient in need thereof, a compound of formula I: or a pharmaceutically acceptable salt thereof, wherein A is an optionally substituted 3-11 membered heterocycle or an optionally substituted C6-10 aryl; W is CH or N; X is each independently CR10R11 or NR10; and wherein X is connected to a carbon atom of the ring; R1 is H, OH, or F; R2 is hydrogen, or one or more substituent each independently selected from halogen, amino, amidino, amido, azido, cyano, guanido, hydroxyl, nitro, nitroso, urea, —OS(O) R10 and R11 are each independently H or C1-6 alkyl; R20 is each independently C1-6 alkyl, C6-10 aryl or 3-10 membered heterocycle; R21 is each independently H, C1-6 alkyl, C6-10 aryl or 3-10 membered heterocycle; R22 and R23 are each independently H or C1-6 alkyl; R24 and R27 are each independently H, C1-6 alkyl, C6-10 aryl, C6-10aryl-C1-6alkyl or 3-10 membered heterocycle; R25 is H or C1-6 alkyl; and R26 is each independently H, C1-6 alkyl, C6-10 aryl, C6-10aryl-C1-6alkyl or 3-10 membered heterocycle; or R25 and R26 are taken together with the atoms to which they are attached to form a 3 to 10 membered heterocycle.