Patent ID: 9357780
Filing Date: 2016-06-07
CPC Classification: A01N,C07D

Claim Text:
1. A process comprising; in step a, treating a compound of Formula XVIIb (where R4 is H) with BOC-anhydride in the presence of a base in a polar aprotic solvent to yield a compound of Formula XXV (where R4 is H), and then in step b, reacting a compound of Formula XXV with a boronic acid of Formula XIXc under Suzuki coupling conditions to provide a compound of Formula XXVI (where R4 is H), and then in step c, treating a compound of Formula XXVI with an electrophilic source of halogen to yield a compound of Formula XXVII (where R4 is F, Cl, Br, or I), wherein: X is N or CR8; R1 is H; R2 is H; R3 is H; R8 is H, or F; and n is 0, 1, or 2.