Patent ID: 9234196
Filing Date: 2016-01-12
CPC Classification: A61K,A61P,C07F,C07H,C12N

Claim Text:
1. A composition comprising a double-stranded ribonucleic acid (dsRNA) for inhibiting expression of transthyretin (TTR) and a lipid formulation, wherein the dsRNA comprises a sense strand and an antisense strand comprising a region complementary to an mRNA encoding transthyretin (TTR), wherein the region of complementarity comprises SEQ ID NO:170 and each strand is 19, 20, 21, 22, 23, or 24 nucleotides in length, the lipid formulation comprising the lipid (6Z,9Z,28Z,31Z)-heptatriaconta-6,9,28,31-tetraen-19-yl 4-(dimethylamino)butanoate (MC3).