Patent ID: 9347950
Filing Date: 2016-05-24
CPC Classification: C07K,G01N

Claim Text:
1. A method for aiding in diagnosis of immune thrombocytopenia comprising: (i) contacting a sample from a subject suspected of having immune thrombocytopenia with a first peptide comprising a moesin fragment consisting of amino acid residues 471-577 of human moesin protein; (ii) detecting the level of anti-moesin autoantibody binding to said first peptide; (iii) contacting the sample with a second peptide comprising a moesin fragment consisting of amino acid residues 1-297 of human moesin protein; (iv) detecting the level of anti-moesin autoantibody binding to said second peptide; (v) comparing the level of anti-moesin autoantibody obtained from step (ii) and the level of anti-moesin autoantibody obtained from step (iv) to a level of anti-moesin autoantibody obtained from a normal reference sample, respectively; and (vi) indicating the subject has immune thrombocytopenia when the subject sample has a higher level of binding to each the first and second peptides compared to the level of binding to the first and second peptides in the normal reference sample.