Patent ID: 9481665
Filing Date: 2016-11-01
CPC Classification: C07D

Claim Text:
1. A method for preparing buparlisib of formula 1, comprising: (1) contacting a compound of formula 2 with a compound of formula 3 to obtain a compound of formula 4; and (2) contacting a compound of formula 6 with a compound of formula 5 and the compound of formula 4 to obtain the buparlisib of formula 1, (2-1) dissolving the compound of formula 6, the compound of formula 5, KOAc and PdCl2(PPh3)2 in DMSO; (2-2) keeping a resulting mixture of step (2-1) under a temperature ranging from about 5° C. to about 15° C. for about 3 hours to about 7 hours; and (2-3) adding the compound of formula 4 into a mixture of step (2-2), and keeping the resulting mixture under a temperature ranging from about 5° C. to about 15° C. for about 12 hours to about 18 hours.