Patent ID: 9512181
Filing Date: 2016-12-06
CPC Classification: A61K,C07K

Claim Text:
1. An immunogenic composition comprising self-assembled granular particles of a fusion polypeptide comprising a) a Granule lattice protein (Grl) comprising a Grl moiety: i) wherein the Grl moiety is selected from the group consisting of Grl 1-9; or ii) wherein the Grl moiety has at least about 95% amino acid sequence identity to SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO:3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7, SEQ ID NO: 8, or SEQ ID NO: 9; and b) an antigen (Ag) moiety, wherein the particles self assembled into granules in a medium comprising a divalent cation, when said divalent cation was present in the medium at a concentration of at least about 0.01 mM.