Patent ID: 9434680
Filing Date: 2016-09-06
CPC Classification: A61P,C07C

Claim Text:
1. A method for the synthesis of a 9-aminomethyl minocycline compound of the following structural formula: the method comprising: a) contacting minocycline with a N-hydroxymethyl pthalimide compound (Pht) in the presence of a water scavenger and an acid under a reaction temperature of 20-35° C. to form a first 9-aminomethyl minocycline intermediate of the following structural formula: b) reacting said first 9-aminomethyl minocycline intermediate formed in step a) with methylamine in the presence of ether and alkyl alcohol to form a second 9-aminomethyl minocycline intermediate of the following structural formula:  and c) treating said second 9-aminomethyl minocycline intermediate formed in step b) through hydrogenation to form said 9-aminomethyl minocycline compound.