Patent ID: 9393272
Filing Date: 2016-07-19
CPC Classification: A61K,C12N

Claim Text:
1. A microcapsule comprising: (a) a liquid aqueous or hydrogel core; (b) a semipermeable membrane layer surrounding said core; (c) live mammalian cells in said core, said cells are human pancreatic islet cells; (d) oxygen-generating particles in said core, said oxygen-generating particles included in said microcapsules in an amount sufficient to lengthen the duration of viability of said animal cells in said microcapsules; wherein said oxygen-generating particles comprise (i) magnesium peroxide, optionally in combination with a biodegradable polymer comprising alginate, and (ii) catalase; (e) an antioxidant, which is trolox; and (f) an auxiliary layer surrounding said semipermeable membrane layer, wherein said auxiliary layer comprises a biodegradable polymer comprised of sodium alginate, said biodegradable polymer containing an angiogenic agent in an amount effective to enhance the growth of blood vessels adjacent said microcapsule.