Patent ID: 9364449
Filing Date: 2016-06-14
CPC Classification: A61K,A61P,C07K

Claim Text:
1. A synthetic oligomer (i) wherein the synthetic oligomer is and wherein at least one and up to 35 amino acid residues are replaced with monomers independently selected from Nap, Nab, Nah, Ngb, Npm, Nnm, Ndp, Nip, Nib, Nmg, and Nchm; or (ii) wherein the synthetic oligomer is X-Gly-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Y (SEQ ID NO: 32); or a salt thereof, and stereoisomers, isotopic variants and tautomers thereof; and wherein at least one and up to 5 amino acid residues are replaced with monomers independently selected from Nap, Nab, Nah, Ngb, Npm, Nnm, Ndp, Nip, Nib, Nmg, and Nchm; or (iii) wherein the synthetic oligomer is X-Gly-Lys-Leu-Val-Phe-Phe-Ala-Glu-Y (SEQ ID NO: 33); or a salt thereof, and stereoisomers, isotopic variants and tautomers thereof; and wherein at least one and up to 4 amino acid residues are replaced with monomers independently selected from Nap, Nab, Nah, Ngb, Npm, Nnm, Ndp, Nip, Nib, Nmg, and Nchm; or (iv) wherein the synthetic oligomer is X-Gly-Lys-Leu-Val-Phe-Phe-Y (SEQ ID NO: 34); or a salt thereof, and stereoisomers, isotopic variants and tautomers thereof; and wherein at least one and up to 4 amino acid residues are replaced with monomers independently selected from Nap, Nab, Nah, Ngb, Npm, Nnm, Ndp, Nip, Nib, Nmg, and Nchm; and Phe is phenylalanine or cyclohexylalanine; and provided that a) the monomer or monomers adjacent to Nmg are other than Gly, Nmg, Ser, Ile, or Tyr; and b) none of -Gly-residues is replaced with Nmg.