Patent ID: 9358210
Filing Date: 2016-06-07
CPC Classification: A61K

Claim Text:
1. Sustained-release pellets which contain tacrolimus as an active ingredient, the sustained-release pellets comprising: a pharmacologically active ingredient layer containing 0.5˜1.5 wt % of tacrolimus as a main ingredient and 5.0˜6.5 wt % of hydroxypropyl methylcellulose as a binder around a core; a primary pharmacologically inactive ingredient layer surrounding the pharmacologically active ingredient layer, and containing 1.5˜1.7 wt % of hydroxypropyl methylcellulose; a sustained-release layer surrounding the primary pharmacologically inactive ingredient layer, and containing 3.6˜4.8 wt % of aqueous ethylcellulose dispersion containing ammonium hydroxide, oleic acid and hypromellose (SURELEASE NG E-7-19050) and 0.3˜0.6 wt % of hydroxypropyl methylcellulose; a secondary pharmacologically inactive ingredient layer surrounding the sustained-release layer, and containing 1.5˜1.7 wt % of hydroxypropyl methylcellulose; and an initial release membrane layer surrounding the secondary pharmacologically inactive ingredient layer, and containing 0.10˜0.15 wt % of tacrolimus and 3.5˜4.0 wt % of hydroxypropyl methylcellulose.