Patent ID: 9340608
Filing Date: 2016-05-17
CPC Classification: A61K,A61P,C07K,C12N,G01N

Claim Text:
1. An isolated fusion protein comprising a human monoclonal antibody or an antigen-binding fragment thereof comprising a heavy chain variable region and a light chain variable region, wherein the heavy chain variable region comprises amino acids 26-33of SEQ ID NO: 1 (CDR1), amino acids 51-58 of SEQ ID NO: 1 (CDR2), amino acids 97-103 of SEQ ID NO: 1 (CDR3) and wherein the light chain variable region comprises amino acids 27-32 of SEQ ID NO: 2 (CDR1), amino acids 50-52 of SEQ ID NO: 2 (CDR2), amino acids 89-97 of SEQ ID NO: 2 (CDR3), wherein the human monoclonal antibody or antigen binding fragment thereof specifically binds human endoplasmin, and wherein the human monoclonal antibody or antigen binding fragment thereof is linked to an effector molecule, wherein the effector molecule is a cytokine or a chemokine.