Patent ID: 9499604
Filing Date: 2016-11-22
CPC Classification: A61K,A61P,C07K,C12N

Claim Text:
1. A TRAIL Mutant Membrane-Penetrating Peptide-alike, wherein the mutant is a protein comprising a Membrane-Penetrating Peptide-alike structure formed by selectively changing an amino acid coding sequence at positions 114-121 of an extracellular fragment of a TRAIL wild-type protein as shown in SEQ ID NO: 5 to a TRAIL mutant protein as shown in SEQ ID NO: 2, namely mutating valine at position 114 into arginine, glutamate at position 116 into arginine, glycine at position 118 into arginine, proline at position 119 into arginine and glutamine at position 120 into arginine, so as to allow the N-terminal of the mutant protein to form an 8-consecutive arginine coding sequence.