Patent ID: 9351941
Filing Date: 2016-05-31
CPC Classification: A61K

Claim Text:
1. A magnetic nanoparticle for tumor therapy, comprising: a magnetic core; a shell fully encapsulating a surface of the magnetic core, wherein the shell is made of a polymer with carboxylic groups; a poly-nucleotide chain connected to a surface of the shell, wherein the poly-nucleotide chain is a poly-adenine chain with an aminated end, and the poly-adenine chain connects to the surface of the shell via the aminated end of the poly-adenine chain; an anti-tumor drug connected to the poly-nucleotide chain, wherein the anti-tumor drug comprises at least one functional group, and each of the functional group is independently a pyrimidine group or a purine group; and an antibody connected to the shell through a hydrophilic polymer chain, wherein the antibody identifies a target tumor, and the hydrophilic polymer chain contains amines on its two ends, wherein the amine on one end connects the carboxylic groups of the shell, and the amine on the other end connects the antibody; wherein the anti-tumor drug is employed to perform tumor growth inhibition or modulation of tumor microenvironment, and wherein a local radio frequency is provided for inducing hyperthermia during the treatment of the magnetic nanoparticle for tumor therapy, and wherein the induced hyperthermia will synchronize the triggered release of anti-tumor modalities and thereby enhance the therapeutic efficacy through synergistic activity.