Patent ID: 9497908
Filing Date: 2016-11-22
CPC Classification: A01H,C07K,C12N

Claim Text:
1. An isolated artificially modified solanaceous Class II defensin polypeptide comprising the amino acid sequence of NaD1 set forth in SEQ ID NO: 2, or an amino acid sequence having at least 70% identity to SEQ ID NO: 2 and at least 70% identity to the C-terminal end of NaD1 set forth in SEQ ID NO: 52, wherein the Loop 1B amino acid sequence at positions 8-13 of SEQ ID NO: 2, or the Loop 1B amino acid sequence at positions equivalent to 8-13 of an amino acid sequence having at least 70% identity to SEQ ID NO: 2 and at least 70% identity SEQ ID NO: 52 after optimal alignment to SEQ ID NO: 2 is replaced by an exogenous Loop 1B amino acid sequence selected from the group consisting of SEQ ID NOs: 29 through 38, and 67 through 79, and wherein the artificially modified solanaceous Class II defensin polypeptide has antifungal activity.