Patent ID: 9387239
Filing Date: 2016-07-12
CPC Classification: A61K,A61P,C12N

Claim Text:
1. A vaccine composition comprising native outer membrane vesicles (NOMVs) isolated from at least two genetically modified meningococcal strains, wherein the NOMVs include different sets of antigens comprising different meningococcal Porin A (PorA) proteins, meningococcal lipooligosaccharides, and at least one conserved meningococcal outer membrane protein, wherein the genetically modified meningococcal strains are modified to comprise inactivation of its lpxL1, synX, and IgtA genes, wherein at least one of the at least two meningococcal strains is genetically modified to express at least two different meningococcal PorA subtype proteins or at least two different meningococcal PorA subtype epitopes, wherein the genetic modification includes insertion of a second porA gene in place of the opaD gene of the at least one meningococcal strain.