Patent ID: 9428488
Filing Date: 2016-08-30
CPC Classification: C07D

Claim Text:
1. A method for producing 4-[5-(pyridin-4-yl)-1H-1,2,4-triazol-3-yl]pyridine-2-carbonitrile of formula (1): the method comprising reacting a compound of formula (2): with isonicotinic acid hydrazide in the presence of an alkali metal alkoxide, to thereby form a compound of formula (3): cyanating the compound (3) with at least one cyanating agent selected from the group consisting of an alkali metal cyanide, zinc cyanide, and a trialkyl cyanide, to thereby form a compound of formula (4): and subjecting the compound (4) to a ring-closure reaction in the presence of at least one acid catalyst selected from the group consisting of an organic acid catalyst and an inorganic acid catalyst.