Patent ID: 9238032
Filing Date: 2016-01-19
CPC Classification: A61K

Claim Text:
1. A method of decreasing dextrorphan plasma levels in a human being comprising co-administering about 150 mg per day to about 560 mg per day of bupropion with dextromethorphan to the human being for at least eight consecutive days, wherein bupropion and dextromethorphan are administered once or twice a day, wherein the human being is an extensive metabolizer of dextromethorphan in need of treatment with dextromethorphan, wherein on the eighth day, the co-administration results in an AUC 0-12 of dextromethorphan that is at least about 20 times the AUC 0-12 that would be achieved by administering the same amount of dextromethorphan without bupropion for eight consecutive days, and wherein a decrease in the dextrorphan plasma level occurs on the first day that bupropion and dextromethorphan are co-administered, as compared to the same amount of dextromethorphan administered without bupropion.