Patent ID: 9402905
Filing Date: 2016-08-02
CPC Classification: A61K,A61P,C07K

Claim Text:
1. A composition comprising an isolated antibody or antibody fragment that immunospecifically binds to human MHC class I polypeptide-related sequence A (MICA), wherein the antibody or antibody fragment comprises a heavy chain variable region (V H ) and a light chain variable region (V L ), wherein the V H complementarity determining region (CDR) 1 comprises the amino acid sequence set forth in SEQ ID NO: 153, the V H CDR2 comprises the amino acid sequence set forth in SEQ ID NO: 156, the V H CDR3 comprises the amino acid sequence set forth in SEQ ID NO:158, the V L CDR1 comprises the amino acid sequence set forth in SEQ ID NO: 160, the V L CDR2 comprises the amino acid sequence set forth in SEQ ID NO: 162 and the V L CDR3 comprises the amino acid sequence set forth in SEQ ID NO:164.