Patent ID: 9523695
Filing Date: 2016-12-20
CPC Classification: A61K,A61P,C07K,G01N

Claim Text:
1. A method of identifying an anti-ROR1 antibody, the method comprising: (i) contacting an antibody with a first ROR1 polypeptide comprising amino acid residues 1-147 of SEQ ID NO:36; (ii) detecting said antibody binding to said first ROR1 polypeptide; (iii) contacting said antibody with a second ROR1 polypeptide comprising amino acid residues 1-147 of SEQ ID NO:37 or amino acid residues 1-147 of SEQ ID NO:36, wherein the isoleucine at position 111 of SEQ ID NO:36 is replaced by asparagine; and (iv) detecting said antibody not binding to said second ROR1 polypeptide, thereby identifying an anti-ROR1 antibody.