Patent ID: 9321789
Filing Date: 2016-04-26
CPC Classification: A61K,A61P,C07B,C07D

Claim Text:
1. A method of producing a compound shown by formula (Y1) or a pharmaceutically acceptable salt thereof: (wherein R x is carbocyclyl optionally substituted by substituent E, heterocyclyl optionally substituted by substituent E, carbocyclyl lower alkyl optionally substituted by substituent E, or heterocyclyl lower alkyl optionally substituted by substituent E comprising the following steps: (Step C) reacting the compound shown by formula (X3), with a compound shown by formula (V3): to obtain a compound shown by formula (X4) (Step D) reacting the compound shown by formula (X4) wherein R R R R R Substituent E is selected from the group consisting of halogen, cyano, hydroxy, carboxy, formyl, amino, oxo, nitro, lower alkyl, halogeno lower alkyl, lower alkyloxy, carbocyclyl optionally substituted by substituent F, heterocyclyl optionally substituted by substituent F, carbocyclyl lower alkyloxy optionally substituted by substituent F, heterocyclyl lower alkyloxy optionally substituted by substituent F, carbocyclyl lower alkylthio optionally substituted by substituent F, heterocyclyl lower alkylthio substituted by substituent F, carbocyclyl lower alkylamino optionally substituted by substituent F, heterocyclyl lower alkylamino optionally substituted by substituent F, carbocyclyloxy optionally substituted by substituent F, heterocyclyloxy optionally substituted by substituent F, carbocyclylcarbonyl optionally substituted by substituent F, heterocyclylcarbonyl optionally substituted by substituent F, carbocyclylaminocarbonyl optionally substituted by substituent F, heterocyclylaminocarbonyl optionally substituted by substituent F, halogeno lower alkyloxy, lower alkyloxy lower alkyl, lower alkyloxy lower alkyloxy, lower alkylcarbonyl, lower alkyloxycarbonyl, lower alkyloxy carbonylamino, lower alkylamino, lower alkylcarbonylamino, lower alkylaminocarbonyl, lower alkylsulfonyl, and lower alkylsulfonylamino; and, Substituent F is selected from the group consisting of halogeno, hydroxy, carboxy, amino, oxo, nitro, lower alkyl, halogeno lower alkyl, and lower alkyloxy; with (R)-3-amino-butan-1-ol, to obtain a compound shown by formula (X5): (Step E) reacting the compound shown by formula (X5) with a compound shown by formula (V6): (wherein R x is as defined above) to obtain a compound shown by formula (X6): and (Step F) reacting the compound shown by formula (X6) through hydroxy deprotection when R with (CH with Pd-C/H with (CH with (CH when R with a halogenating agent selected from the group consisting of N-bromosuccinimide, N-chlorosuccinimide and sulfuryl chloride followed by addition of (CH when R to obtain the compound shown by formula (Y1) or a pharmaceutically acceptable salt thereof.