Patent ID: 9243071
Filing Date: 2016-01-26
CPC Classification: A61K,A61P,C07K

Claim Text:
1. A fusion protein, comprising (a) protein (X), wherein protein (X) is isoform 1 or isoform 2 of human nAChRα1 subunit, or a ligand-binding portion thereof, (b) protein (A), wherein protein (A) is a human antibody heavy chain constant region, or a portion thereof having cytotoxic activity, and (c) a linker peptide (L) consisting of an amino acid sequence represented by the formula (Gly-Gly-Gly-Gly-Ser)n (SEQ ID NO: 22) (in the formula, n is an integer of 1 to 4), or the formula Pro-(Gly-Gly-Gly-Gly-Ser)n (SEQ ID NO: 23) (in the formula, n is an integer of 1 to 4), wherein protein (X), the linker peptide (L) and protein (A) are connected in this order by means of a peptide bond from N terminal to C terminal.