Patent ID: 9528991
Filing Date: 2016-12-27
CPC Classification: A61K,A61P,C12N,C12Q,G01N

Claim Text:
1. A method for treating cancer, comprising: obtaining a specimen of cancer tissue and normal tissue from a patient; extracting total protein and RNA from the cancer tissue and normal tissue; obtaining a protein expression profile of the cancer tissue and normal tissue; identifying over-expressed proteins in the cancer tissue; comparing the protein expression profile to a gene expression profile; identifying at least one prioritized protein target; designing a RNA interference expression cassette to modulate the expression of at least one gene encoding the prioritized target protein, wherein the RNA interference expression cassette encodes one or more shRNA molecules, siRNA molecules, or shRNA molecules that direct the target RNA into both a cleavage-dependent RISC and a cleavage-independent RISC degradation pathway; incorporating the RNA interference expression cassette into a delivery vehicle; and providing a patient with an effective amount of the delivery vehicle sufficient to treat the cancer.