Patent ID: 9273326
Filing Date: 2016-03-01
CPC Classification: A61K,C07K,C12N

Claim Text:
1. A replication deficient HSV-1 viral vector having a genomic DNA construct comprising: a) at least two tetR nucleotide sequences coding for the tetracycline repressor, wherein the expression of each tetR nucleotide sequence is under the control of a VP-16 responsive immediate early promoter selected from the group consisting of: the ICP-0 immediate early promoter of HSV-1; the ICP-4 immediate early promoter of HSV-1; LAP2/ICP0; and LAP2/ICP4; b) an additional promoter wherein said additional promoter includes a TATA element; c) a tetracycline operator sequence positioned between 6 and 24 nucleotides 3′ to said TATA element; and d) a structural sequence whose expression is regulated by said additional promoter and wherein