Patent ID: 9506064
Filing Date: 2016-11-29
CPC Classification: C12N

Claim Text:
1. A composition comprising a molecule and a physiologically acceptable carrier, wherein the molecule comprises an aptamer linked to a Dicer substrate siRNA, wherein the aptamer is an anti-gp120 aptamer, wherein the Dicer substrate siRNA is directed against an HIV-1 target sequence, wherein the HIV-1 target sequence is tat/rev, and wherein the aptamer is selected from: (a) an anti-gp120 aptamer that comprises the nucleotide sequence set forth in SEQ ID NO: 8, (b) an anti-gp120 aptamer that comprises the nucleotide sequence set forth in SEQ ID NO: 9, and (c) an anti-gp120 aptamer of (a) or (b) which is modified to contain 2′-F substituted nucleotides.