Patent ID: 9249427
Filing Date: 2016-02-02
CPC Classification: A61K,A61P,C07K,C12N,Y02A

Claim Text:
1. A recombinant viral vector comprising a nucleic acid sequence encoding a human cytomegalovirus (HCMV) backbone vector and at least one human immunodeficiency virus (HIV)-derived antigen, wherein the recombinant viral vector: (a) comprises a deletion in gene UL82 that eliminates expression of a functional pp71 protein, (b) is deficient in host to host spread, (c) infects a HCMV seropositive host upon administration of said recombinant viral vector, and (d) induces and maintains a long-term effector memory T cell response to the at least one HIV-derived antigen in said seropositive host.