Patent ID: 9447156
Filing Date: 2016-09-20
CPC Classification: A61K,A61P,C07K,C12N,C12Y,G01N

Claim Text:
1. A method for identifying compounds that bind to an E2-binding pocket in a NEDD8 co-E3 protein, said method comprising performing a competitive binding assay using a peptide selected from the group consisting of: a peptide having the sequence set forth in SEQ ID NO: 7, 12, 13, 14, 15, or 16, wherein the nitrogen atom of the amino terminus of said peptide is covalently bound to at least one —R group, wherein said —R group is a substituted or unsubstituted alkyl, alkenyl, alkynyl, aryl, heteroaryl or has Formula (I):  wherein said —R wherein said peptide can comprise a hydrophobic staple, and wherein said peptide binds to an E2-binding pocket of Dcn1, DCUN1D1, DCUN1D2, DCUN1D3, DCUN1D4, or DCUN1D5.