Patent ID: 9227948
Filing Date: 2016-01-05
CPC Classification: C07C,C07D,C07F,Y02P

Claim Text:
1. A process for the preparation of 2-substituted-2-(6-(substituted)-7-methylbenzo[d][1,3]dioxol-4-yl)acetic acid derivatives of formula-I, wherein R said process comprising: (i) reacting 2,4-dihydroxy-3-methylbenzaldehyde with an etherification reagent in the presence of a base (or acid in case of tetrahydropyran-2-yl protection) and a solvent at 0-100° C. to produce a mono-protected derivative of formula-XII, wherein R (ii) oxidizing said mono-protected derivative of formula-XII with an oxidizing agent in the presence of a base and a solvent at pH 7-14 to obtain a dihydroxy compound of formula-XIII, (iii) reacting said dihydroxy compound of formula-XIII with a base and an aldehyde compound of formula-XIV, wherein Y and R wherein R (iv) reacting said compound of formula-XV with a dihalomethane in the presence of a base and a solvent at 15-120° C. to produce a methylenedioxy derivative of formula-XVI wherein R (v) converting the hydroxyl group of said methylenedioxy derivative of formula-XVI to X wherein X is as defined above using a suitable reagent in the presence of a base at −78 to 40° C. to obtain said 2-substituted-2-(6-(substituted)-7-methylbenzo[d][1,3]dioxol-4-yl)acetic acid derivative of formula-I