Patent ID: 9410214
Filing Date: 2016-08-09
CPC Classification: C12N,C12P,C12Y,Y02P

Claim Text:
1. A genetically modified yeast host cell capable of producing an isoprenoid, acetyl-CoA or an acetyl-CoA derived compound, the genetically modified yeast host cell comprising: (a) a heterologous nucleic acid encoding a phosphoketolase (PK; EC 4.1.2.9); (b) a heterologous nucleic acid encoding a phosphotransacetylase (PTA; EC 2.3.1.8); and (c) a functional disruption of an endogenous glycerol-1-phosphatase enzyme (EC 3.1.3.21) that converts acetyl phosphate to acetate, wherein the genetically modified yeast host cell produces an increased amount of an isoprenoid, acetyl-CoA or an acetyl-CoA derived compound compared to yeast cells which are not geneically modified in the same way.