Patent ID: 9415099
Filing Date: 2016-08-16
CPC Classification: A61K,A61N,C07K,C12N

Claim Text:
1. A method of inducing an immune response in a subject, the method comprising: (a) administering a first Gag conserved element nucleic acid that encodes a first Gag conserved element polypeptide that comprises six conserved elements from Gag to the subject, wherein the conserved elements are from different regions of Gag, and further, wherein each conserved element is at least 12 amino acids in length, but less than 30 amino acids in length and the conserved elements are not contiguous; (b) administering a second Gag conserved element nucleic acid that encodes a second Gag conserved element polypeptide that comprises at least one variant of a conserved element polypeptide differs from the variant in the first polypeptide by 1, 2, or 3 amino acids; and (c) administering a nucleic acid encoding a full-length Gag protein; wherein the region of the nucleic acid encoding the full-length Gag protein encodes only the full-length Gag protein.