Patent ID: 9370514
Filing Date: 2016-06-21
CPC Classification: A61K

Claim Text:
1. A process for preparing micronized particles comprising a poorly water soluble bioactive agent, the process comprising (a) heating an aqueous suspension comprising the poorly water soluble bioactive agent to a temperature of from about 100° C. to about 280° C. at a pressure of from greater than standard pressure to about 1,000 psi to form a superheated continuous phase comprising molten droplets of the poorly water soluble bioactive agent dispersed in superheated water; (b) reducing the size of the molten droplets while maintaining the superheated continuous phase at a temperature of from about 100° C. to about 280° C. and a pressure of from greater than standard pressure to about 1,000 psi, wherein reducing the size of the molten droplets comprises a low energy process; and c) cooling the molten droplets to form micronized particles comprising the poorly water soluble bioactive agent.