Patent ID: 9375495
Filing Date: 2016-06-28
CPC Classification: A61K,B82Y,C01G,C01P,H01F,Y10S

Claim Text:
1. An MRI contrast agent comprising zinc-containing metal oxide nanoparticles have a chemical formula of: (a) Zn wherein the dispersibility of the zinc-containing metal oxide nanoparticles to water is in the range of 1 μg/ml to 500 mg/ml, and the hydrodynamic diameter of the nanoparticles that are dispersed in water is in the range of 1 nm to 500 μm; wherein the zinc-containing metal oxide nanoparticle itself is dispersed in water, or the zinc-containing metal oxide nanoparticle is coated with water-soluble multi-functional group ligands to be dispersed in an aqueous solution; wherein the zinc-containing metal oxide nanoparticles have a saturation magnetization of 100 emu/g or more (magnetic atom), wherein the zinc-containing metal oxide nanoparticles are prepared by a method comprising synthesizing water-insoluble, zinc-containing nanoparticles in organic solvents, and wherein the zinc-containing metal oxide nanoparticles comprise zinc incorporated into a tetrahedron interstitial hole.