Patent ID: 9462794
Filing Date: 2016-10-11
CPC Classification: A01K,A61K,C07K,C12N,C12Y,G01N

Claim Text:
1. A rodent whose genome comprises a replacement of exons 2, 3 and 4 of a rodent SIRPα gene at an endogenous rodent SIRPα locus with exons 2, 3 and 4 of a human SIRPα gene to form a humanized SIRPα gene, wherein said humanized SIRPα gene is operably linked to a rodent SIRPα promoter at said endogenous rodent SIRPα locus, and expresses in said rodent a humanized SIRPα protein comprising an extracellular portion of the human SIRPα protein encoded by said human SIRPα gene and an intracellular portion of the rodent SIRPα protein encoded by said rodent SIRPα gene, and wherein the rodent is selected from a mouse or a rat.