Patent ID: 9445996
Filing Date: 2016-09-20
CPC Classification: A01N,A61K,A61P,C01B

Claim Text:
1. An extended release generator of therapeutic nitric oxide that includes at least two separate reactant components that are not mixed and do not generate or include nitric oxide (NO) until the extended release generator of therapeutic nitric oxide is applied to a patient, the extended release generator comprising: a first reactant component including a nitrite salt in a chemically-stable form provided by microencapsulation in a polymer matrix that forms a dry environment but that is diffusible to acidic aqueous solutions; and a second reactant component including a viscous aqueous acidified gel composition comprising an acidifying agent, a reductant, and a gelling agent, characterized by having a viscosity of that provided by aqueous solutions of from 0.73 to 2.18 grams per 100 mL of an aqueous solution of hydroxy ethyl cellulose (HEC) having a mean molecular weight of 750,000, wherein the acidifying agent and reductant may be the same agent, and wherein the second reactant component has sufficient acidity and reductive capability to covert the nitrite salt to nitric oxide and slow the oxidation of nitric oxide to nitrogen dioxide.