Patent ID: 9255271
Filing Date: 2016-02-09
CPC Classification: A61P,C07K,C12N,C12Q,C12Y,G01N

Claim Text:
1. A method of inhibiting expression or activity of lysyl oxidase-like 2 (LOXL2) protein in a subject having pulmonary alveolar proteinosis (PAP), the method comprising administering to the subject, an effective amount of a polynucleotide that inhibits the expression or activity of lysyl oxidase-like 2 (LOXL2) protein, thereby inhibiting the expression or activity of lysyl oxidase-like 2 (LOXL2) protein in the subject, wherein the polynucleotide comprises: a first sequence comprising a nucleic acid sequence of SEQ ID NO: 20 or SEQ ID NO: 21, a second sequence comprising a region of complementarity to the nucleic acid sequence of SEQ ID NO: 20 or SEQ ID NO: 21, wherein the region of complementarity is at least 19 bases in length, and a linking sequence that joins the first sequence to the second sequence, wherein the polynucleotide forms a hairpin-loop structure having a double-stranded stem region of between 19 and 21 base pairs in length that comprises the region of complementarity, and wherein ends of the double-stranded stem region are connected by the linking sequence.