Patent ID: 9492431
Filing Date: 2016-11-15
CPC Classification: A61K,A61P

Claim Text:
1. A method of reducing scar formation in a subject having a keratoconjunctive disorder, said method comprising administering to said subject an RARγ agonist, or an ester or salt thereof, in an amount effective to reduce scar formation, wherein said RARγ agonist is (E)-4-(2-{3-[(1H-pyrazole-1-yl)methyl]-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalene-2-yl}vinyl)benzoic acid (R667), 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalene acid (CD437), 3-fluoro-4-[2-hydroxy-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalene-2-yl)acetylamino]benzoic acid (BMS961), (2E)-3-(4-carboxyphenyl)-1-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalene-2-yl)-2-propene-1-one oxime (NRX204647), 4-[7-(1-adamantyl)-6-hydroxynaphthalene-2-yl]benzoic acid (CD1530), an ester thereof, or a salt thereof.