Patent ID: 9365544
Filing Date: 2016-06-14
CPC Classification: C07D

Claim Text:
1. A process for preparing a hydrochloride salt of a compound of formula (IV-HCl) wherein a compound of formula (III) in free base form is reacted with hydrogen chloride in the presence of an alcohol, and then with ammonia in an aqueous medium to form an amidine hydrochloride salt of formula (IV-HCl) in the presence of water; wherein in a step prior to the formation of the hydrochloride salt of the compound of formula (IV-HCl) is reacted a diamine of formula (II)  with carboxylic acid (I)  in the presence of a coupling reagent selected from the group consisting of N,N′-dicyclohexylcarbodiimide, N,N′-carbonyldiimidazole, and carbonyl-di-(1,2,4-triazole) and a solvent selected from the group consisting of isopropyl acetate, ethyl acetate and butyl acetate; subsequent reaction in the presence of acetic acid to obtain a mixture; and the mixture is heated between 75° C. and 130° C. to prepare the compound of formula (III)