Patent ID: 9265597
Filing Date: 2016-02-23
CPC Classification: A61F,A61L,A61P

Claim Text:
1. A medical device comprising: an implantable structure; a basecoat layer affixed to the implantable structure, the basecoat layer comprising a first polymeric material; probucol, in therapeutic dosages, releasably affixed to the implantable structure for the treatment of restenosis following vascular injury, the probucol being incorporated into the basecoat; rapamycin, in therapeutic dosages, releasably affixed to the implantable structure for the treatment of restenosis following vascular injury, the rapamycin being incorporated into the basecoat; and a topcoat layer affixed to the basecoat layer to control the elution rate of the probucol and the rapamycin, the topcoat layer comprising a second polymeric material and the basecoat layer comprising the first polymeric material being immiscible and chemically incompatible polymeric materials, wherein the first polymeric material includes a fluoropolymer comprising a copolymer of polyvinylidenefluoride-co-hexafluoropropylene and the second polymeric material includes at least 150 micrograms of an acrylate comprising poly(n-butylmethacrylate) layer wherein the basecoat and the topcoat are affixed as separate and distinct layers upon each other and configured to create a chemical and physical barrier to elution of the rapamycin and the probucol, the basecoat and the topcoat do not blend.