Patent ID: 9382228
Filing Date: 2016-07-05
CPC Classification: A61P,C07D

Claim Text:
1. A compound of Formula I, or a pharmaceutically acceptable salt, enantiomer, stereoisomer, or tautomer thereof, wherein: A is selected from the group consisting of C1-C6 alkyl, deutero-C1-C6 alkyl wherein the alkyl chain is partially or completely deuterated, branched C3-C8alkyl, fluoroC1-C6alkyl wherein the alkyl is fully or partially fluorinated, C3-C8carbocyclyl, C6-C12 spirobicycloalkyl, adamantyl, bicyclo[2.2.1]heptanyl, and bicyclo[2.2.2]octyl, and wherein each A moiety may be further substituted with one, two, or three R3 moieties; W is a pyrrolyl, furanyl, thienyl, oxazolyl, thiazolyl, isoxazolyl, isothiazolyl, imidazolyl, pyrazolyl, oxadiazolyl, thiadiazolyl, triazolyl, tetrazolyl, pyridinyl, pyrimidinyl, pyrazinyl, pyridazinyl, triazinyl, or phenyl, and wherein each W is optionally substituted by one, two, or three R5; each X1, X2, and X3 is individually and independently hydrogen, C1-C6 alkyl, or fluoro-C1-C6 alkyl wherein the alkyl chain is partially or completely fluorinated; Z1 is CX3; Z2 is CX1; Z3 is CH; each R1 and R2 is individually and independently H, C1-C6 alkyl, fluoroC1-C6alkyl wherein the alkyl is fully or partially fluorinated, hydroxyl, C1-C6 alkoxy, fluoroC1-C6alkoxy wherein the alkyl group is fully or partially fluorinated, or cyano; each R3 is individually and independently H, halogen, C1-C6 alkyl, fluoro-C1-C6 alkyl wherein the alkyl chain is partially or completely fluorinated, branched C3-C8 alkyl, C3-C8 cycloalkyl, C1-C6 alkoxy, fluoro-C1-C6 alkoxy wherein the alkyl chain is partially or completely fluorinated, branched C3-C6 alkoxy, hydroxyl, or cyano; each R4 is individually and independently hydrogen; each R5 is individually and independently hydrogen, C1-C6 alkyl, deutero-C1-C6 alkyl wherein the alkyl chain is partially or completely deuterated, branched C3-C8 alkyl, halogen, cyano, fluoro-C1-C6 alkyl wherein the alkyl chain is partially or completely fluorinated, —(CH each R7 is independently and individually selected from the group consisting of and wherein the symbol (##) is the point of attachment to R5 moieties containing a R7 moiety; each R7 is optionally substituted with —(R10) each R8 and R9 is individually and independently H, C1-C6 alkyl, fluoro-C1-C6 alkyl wherein the alkyl chain is partially or completely fluorinated, or branched C3-C8 alkyl; each R10 is C1-C6 alkyl; each m is individually and independently 0, 1, 2, or 3; each n is individually and independently 0, 1, 2, or 3; each p is 0, 1, 2, or 3; and each q is 0, 1, 2, or 3.