Patent ID: 9447183
Filing Date: 2016-09-20
CPC Classification: A61K,A61P,C07K,G01N,Y02A

Claim Text:
1. A method for reducing human IL-1 activity in a human subject in need thereof, comprising administering to the human subject a binding protein, wherein the binding protein comprises first and second polypeptide chains, wherein said first polypeptide chain comprises a first VD1-(X1)n-VD2-C-(X2)n, wherein: VD1 is a first heavy chain variable domain; VD2 is a second heavy chain variable domain; C is a heavy chain constant domain; X1 is a linker with the proviso that it is not CH1; X2 is an Fc region; and n is independently 0 or 1; and wherein said second polypeptide chain comprises a second VD1-(X1)n-VD2-C-(X2)n, wherein: VD1 is a first light chain variable domain; VD2 is a second light chain variable domain; C is a light chain constant domain; X1 is a linker with the proviso that it is not CH1; X2 does not comprise an Fc region; and n is independently 0 or 1; wherein, in said first polypeptide chain, VD1 comprises the amino acid sequence of SEQ ID NO: 204; and VD2 comprises the amino acid sequence of SEQ ID NO: 213; wherein, in said second polypeptide chain, VD1 comprises the amino acid sequence of SEQ ID NO: 238; and VD2 comprises the amino acid sequence of SEQ ID NO: 216; and wherein the binding protein binds human IL-1β and human IL-la, such that the human IL-1 activity in the human subject is reduced.