Patent ID: 9333222
Filing Date: 2016-05-10
CPC Classification: A61K,A61P

Claim Text:
1. A method of increasing a level of NPC1 protein in a cell, comprising: selecting a cell having a mutant NPC1 gene or expressing a mutant NPC1protein; and contacting the cell with an effective amount of a class I-specific histone deacetylase inhibitor, thereby increasing the level of NPC1 protein in the cell; wherein the class I-specific histone deacetylase inhibitor has a Ki of less than 1 μM for at least one class I histone deacetylase; and wherein the class I-specific histone deacetylase inhibitor is selected from the group consisting of trichostatin A, LBH-589(Panobinostat), and SAHA (Vorinostat).