Patent ID: 9434982
Filing Date: 2016-09-06
CPC Classification: C12Q,G01N

Claim Text:
1. A method of detecting a target polynucleotide, comprising: a) contacting a coded molecule with a target polynucleotide, wherein the coded molecule comprises b) modifying the coded molecule by modifying the target probe with a modifying agent following hybridizing of the target probe with the target polynucleotide, wherein the modified target probe is indicative of the target polynucleotide hybridized to the target probe; c) translocating the modified coded molecule through a nanopore and detecting a signal pattern associated with the modified coded molecule; and d) comparing the detected signal pattern to a signal pattern of an unmodified coded molecule, wherein a difference in the detected signal pattern of the modified coded molecule compared to the signal pattern of the unmodified coded molecule indicates the presence of the target polynucleotide.