Patent ID: 9345498
Filing Date: 2016-05-24
CPC Classification: A61B,A61K,A61N,A61P,B82Y,C12Y,H01F,Y10S

Claim Text:
1. A method of increasing fluid flow within vasculature of a subject through external magnetomotive manipulation of magnetic nanoparticles introduced within the vasculature, the method comprising: introducing a therapeutic agent within vasculature of a subject, the therapeutic agent configured to have a therapeutic effect on a therapeutic target within the vasculature; administering a plurality of magnetic nanoparticles within the vasculature; causing a magnet external to the vasculature and having a magnetic field and a directed magnetic gradient to be positioned and to rotate in a manner sufficient to cause the magnetic nanoparticles to collectively form a plurality of agglomerates within the vasculature and to travel within the vasculature toward a therapeutic target in response to the rotating magnetic field and the directed magnetic gradient of the magnet; and causing the agglomerates to generate a circulating fluid motion proximal to the therapeutic target by setting a rotational frequency of the rotating magnetic field, a plane of the rotating magnetic field with respect to the therapeutic target, and a distance of the rotating magnetic field with respect to the therapeutic target, wherein the circulating fluid motion facilitates contact of the therapeutic agent with the therapeutic target by enhancing delivery of the therapeutic agent to the therapeutic target, thereby providing more effective interaction of the therapeutic agent with the therapeutic target.