Patent ID: 9278067
Filing Date: 2016-03-08
CPC Classification: A61K,A61P,C12N

Claim Text:
1. A method for producing micelles with negatively charged entrapped therapeutic agents, comprising: a) combining an effective amount of a negatively charged therapeutic agent with a buffer solution containing about 20% to about 80% ethanol and an effective amount of a cationic lipid in a ratio where about 30% to about 90% the negatively charged atoms on the therapeutic agents are neutralized by positive charges on the cationic lipids to form an electrostatic micelle complex; and b) combining the electrostatic micelle complex of step a) with an effective amount of a fusogenic-karyophilic peptide conjugate in a ratio wherein the negatively charged therapeutic agents are almost completely neutralized by a majority of the cationic lipids and fusogenic-karyophilic peptide conjugates, thereby producing micelles with entrapped therapeutic agents.