Patent ID: 9393194
Filing Date: 2016-07-19
CPC Classification: A61K

Claim Text:
1. A biocarrier for delivery of a bioactive substance near/into a target cell, comprising: a bioactive substance-loaded core with a positive charge, wherein the bioactive substance-loaded core consists of DNA and a polycation; wherein the polycation is formed by incorporation of a monomer selected from the group consisting of following: and one or more block copolymer, each block copolymer comprises a zwitterionic block and an anchoring block, wherein the anchoring block is with a negative charge, the zwitterionic block is formed by incorporation of a zwitterionic monomer, and the zwitterionic monomer is a sulfobetaine compound; wherein the anchoring block binds to the core by electrostatic attraction, and the zwitterionic block extends outwardly to increase the biocarrier stability in mammalian blood.