Patent ID: 9453228
Filing Date: 2016-09-27
CPC Classification: A61K,A61P,C12N

Claim Text:
1. An immune regulatory oligonucleotide (IRO) compound comprising the sequence 5′-CTATCTGUYZTTCTCTGT-3′ (SEQ ID NO: 102), wherein G is 2′-OMe-G and U is 2′-OMe-U and wherein YZ is an oligonucleotide motif that is CpG, C*pG, C*pG* or CpG* wherein C is deoxycytosine, C* is 2′-deoxythymidine, 1-(2′-deoxy-β-D-ribofuranosyl)-2-oxo-7-deaza-8-methyl-purine, 2′-dideoxy-5-halocytosine, 2′-dideoxy-5-nitrocytosine, arabinocytidine, 2′-deoxy-5-hydroxycytidine, 2′-deoxy-N4-alkyl-cytidine, 2′-deoxy-4-thiouridine, or other pyrimidine nucleoside analogs; G is deoxyguanosine, and G* is 2′-deoxy-7-deazaguanosine, 2′-deoxy-6-thioguanosine, arabinoguanosine, 2′-deoxyinosine, or other purine nucleoside analogs.