Patent ID: 9512193
Filing Date: 2016-12-06
CPC Classification: A61K,A61P,C07K

Claim Text:
1. A recombinant or synthetic p15 protein variant comprising a p15 protein in which at least one hydrophobic amino acid residue that is externally exposed on the tertiary structure of the p15 protein in aqueous solution is substituted with a hydrophilic amino acid, wherein the hydrophobic amino acid is leucine (L), cysteine (C), valine (V), phenyl alanine (F), tryptophan (W), isoleucine (I), proline (P), methionine (M), or a combination thereof; and the hydrophilic amino acid is lysine (K), aspartic acid (D), glutamic acid (E), glutamine (Q), asparagine (N), serine (S), alanine (A), threonine (T), arginine (R), or a combination thereof.