Patent ID: 9334298
Filing Date: 2016-05-10
CPC Classification: A61K,A61P,C07F,Y10T

Claim Text:
1. A method for preparing a microsphere that comprises a lanthanide metal phosphate complex, the method comprising: (a) providing an organic lanthanide metal complex microsphere, wherein the lanthanide metal is present in an amount of more than 20 wt. %, based on total weight of the microspheres, and wherein the organic lanthanide metal complex comprises a lanthanide ion and organic ligands with which the lanthanide ion forms the complex; and thereafter (b) replacing at least part of the organic ligands in the organic lanthanide metal complex microsphere with phosphate in a chimie douce reaction, wherein the lanthanide metal is present in the resulting microsphere in an amount of more than 20 wt. %, based on total weight of the microsphere, wherein the lanthanide metal complex in the resulting microsphere comprises a lanthanide ion and phosphate, and wherein the diameter of the microsphere ranges from about 200 nm to about 300 μm.