Patent ID: 9428587
Filing Date: 2016-08-30
CPC Classification: A61K,A61P,C07K,G01N

Claim Text:
1. An antigen binding site for binding to a P2X 7 receptor, the antigen binding site being defined by a general formula comprising: wherein: FR1, FR2, FR3, FR4, FR1a, FR2a, FR3a and FR4a are each framework regions; CDR1, CDR2, CDR3, CDR1a, CDR2a, CDR3a are each complementarity determining regions; wherein: CDR1 has an amino acid sequence of KASQNVGTNVA (SEQ ID NO: 5) CDR2 has an amino acid sequence of SASFRYS (SEQ ID NO: 6) CDR3 has an amino acid sequence of QQYNSYPFT (SEQ ID NO: 33) CDR1a has an amino acid sequence of SYYMS (SEQ ID NO: 23) CDR2a has an amino acid sequence of AINSNGGSTYYPDTVKG (SEQ ID NO: 24) CDR3a has an amino acid sequence selected from the group consisting of HYSSRFFDV (SEQ ID NO: 34), NFKLMYYNV (SEQ ID NO: 13), NYRGDYYET (SEQ ID NO: 8), NFLESYFEA (SEQ ID NO: 7), NYLPMYYEV (SEQ ID NO: 12), HYIKVYYEA (SEQ ID NO: 15), HYSSRFFEV (SEQ ID NO: 16), NFRVMFFKA (SEQ ID NO: 17), HFQRGYYNI (SEQ ID NO: 10), YHVIQYLGP (SEQ ID NO: 19), HYSKEYYNI (SEQ ID NO: 9), YFPLVYYDV (SEQ ID NO: 11), DFTVPFYNA (SEQ ID NO: 20), NYDKKYFDV (SEQ ID NO: 21).