Patent ID: 9474794
Filing Date: 2016-10-25
CPC Classification: A61K,A61P,C07K

Claim Text:
1. A composition comprising a mixture of at least 4 antibodies and/or fragments of said antibodies, wherein: said antibodies and/or antibody fragments bind to four proteins selected from the group consisting of adrenomedullin, calcitonin receptor like receptor (CLR), receptor activity-modifying protein 2 (RAMP2) and receptor activity-modifying protein 3 (RAMP3) each of said antibodies and/or antibody fragments bind to a different protein, said antibodies and/or antibody fragments are antagonists of adrenomedullin, CLR, RAMP2 and RAMP3, one of the at least four antibodies and/or antibody fragments binds to an extracellular domain of CLR and is obtained by immunization of an animal with a peptide sequence selected from the group consisting of SEQ ID No. 3 and SEQ ID No. 4, one of the at least four antibodies and/or antibody fragments binds to an extracellular domain of RAMP2 and is obtained by immunization of an animal with a peptide sequence selected from the group consisting of SEQ ID No. 5 and SEQ ID No. 6, and/or one of the at least four antibodies and/or antibody fragments binds to an extracellular domain of RAMP3 and is obtained by immunization of an animal with a peptide sequence selected from the group consisting of SEQ ID No. 7, SEQ ID No. 8 and SEQ ID No. 9.