Patent ID: 9339562
Filing Date: 2016-05-17
CPC Classification: A61K,B22F,B82Y,C22C

Claim Text:
1. A method of imaging a subject comprising: administering to a subject an effective amount of a contrast agent, scanning the subject with a magnetic resonance device and an X-ray computed tomography device, and generating a magnetic resonance image and a computed tomography image of the subject from the scanning, wherein the contrast agent contains (i) nanoparticles, each of which includes a metal alloy core and a plurality of hydrophilic molecules covalently bound to the metal alloy of the metal alloy core, the metal alloy core having an average diameter of 1-25 nm and composed of a metal alloy containing a first metal and a second metal, in which the first metal has an X-ray absorption coefficient of 6-11 cm 2 /g at 50 kiloelectron volt and the second metal is paramagnetic, and (ii) an aqueous solvent in which the nanoparticles are dispersed, wherein the nanoparticles are prepared by sonicating a mixture of the metal alloy core and the plurality of hydrophilic molecules.