Patent ID: 9278068
Filing Date: 2016-03-08
CPC Classification: A61K,A61P

Claim Text:
1. A vesicle composition, comprising: a first liposome, comprising: a first phospholipid; cholesterol; and a phospholipid-polyethylene glycol-boronic acid derivative conjugate; a second liposome, comprising: a second phospholipid; cholesterol; and a phospholipid-polyethylene glycol-glycosyl conjugate, at least one of the first liposome or the second liposome respectively encapsulating a first therapeutic compound or a second therapeutic compound; and the phospholipid-polyethylene glycol-boronic acid derivative conjugate of the first liposome and the phospholipid-polyethylene glycol-glycosyl conjugate of the second liposome together to form at least one reversible boronic-glycosyl crosslink between the first liposome and the second liposome, provided that when: a glycosyl moiety of the phospholipid-polyethylene glycol-glycosyl conjugate comprises a glucosyl moiety, a galactosyl moiety, or a mannopyranosidyl moiety; the first liposome encapsulates the first therapeutic compound; the second liposome encapsulates the second therapeutic compound; and the first liposome is coupled to the second liposome by the at least one reversible boronic-glycosyl crosslink, the phospholipid-polyethylene glycol-boronic acid derivative conjugate is not represented by wherein n=30-60.