Patent ID: 9394263
Filing Date: 2016-07-19
CPC Classification: A61P,C07D

Claim Text:
1. A compound of the formula 1 wherein: W and X are the same or different and are independently selected from H, C X and W together with the nitrogen to which they are bound can form a C Y is C R1 is selected from H, halo, C R2 is selected from H, halo, C R3 is selected from H, halo, C R4 is H or C R5 and R6 are the same or different and are independently selected from H, C R5 and R6 together with the carbon to which they are bound can form a C V is S, O or SO2 Z is selected from C aryl, optionally substituted by C heteroaryl, optionally substituted by cyano, C polycyclic aromatics, polycyclic heteroaromatics, optionally substituted by halo, SO mixed aryl and non-aryl polycycles and mixed aryl and non-aryl polyheterocycles; optionally substituted by SO R7 is C R8 and R9 are the same or different and independently selected from H, C R8′ is selected from H and C R9′ is selected from HOOC—C or R8′ and R9′ form together with the nitrogen to which they are attached a heterocyclyl, substituted by hydroxy-C R10 is C or a pharmaceutically acceptable salt thereof; and wherein acyl is —C(O)R11 where R11 is selected from H, alkyl, aryl, arylalkyl, and heterocyclyl; heterocycle is selected from pyrrolidin-2-yl, pyrrolidin-3-yl, piperidinyl, and morpholin -4-yl; and heteroaryl is selected from thienyl, furyl, indolyl, pyrrolyl, pyridinyl, pyrazinyl, oxazolyl, thiaxolyl, quinolinyl, pyrimidinyl, imidazole, triazolyl and tetrazolyl.