Patent ID: 9519650
Filing Date: 2016-12-13
CPC Classification: G06F,G16B

Claim Text:
1. A computer-implemented method of compressing, for a plurality of subjects, genetic data corresponding to at least one bi-allelic marker having at least one minor allele frequency associated therewith, the method utilizing at least two compression algorithms and comprising: for each of the at least one bi-allelic marker, using the computer processor, analyzing the compressed genetic data without decompression, wherein the at least two compression algorithms are selected from (i) a binary-encoding algorithm, (ii) an algorithm wherein total numbers and unique indices of (a) all subjects having a rare homozygous genotype for a marker, (b) all subjects having a heterozygous genotype for the marker, and (c) all subjects having an unknown genotype for the marker are expressed in binary numbers, and (iii) an algorithm wherein the total numbers and unique indices of (a) all subjects having a rare homozygous genotype for a marker and (b) all subjects having an unknown genotype for the marker are expressed in binary numbers, and the unique indices of all subjects having a heterozygous genotype for the marker are expressed in a single n-digit number, where n is the number of subjects.