Patent ID: 9315554
Filing Date: 2016-04-19
CPC Classification: A61K,A61P,C07K

Claim Text:
1. A recombinant nucleic acid molecule comprising a nucleic acid sequence encoding a Staphylococcus aureus Protein A (SpA) D domain segment having (a) at least one amino acid substitution that disrupts Fc binding and (b) at least one amino acid substitution that disrupts VH3 binding and (c) an amino acid sequence that is at least 70% identical to the amino acid sequence of SEQ ID NO: 2, wherein the amino acid substitutions correspond to amino acids at position 9, 10, 36 and/or 37 of SEQ ID NO: 2; and wherein the substitutions at amino acids corresponding to positions 9 and 10 are with a glycine residue and the substitutions at amino acids corresponding to positions 36 and 37 are with a serine residue; or wherein the substitutions at amino acids corresponding to positions 9 and 10 are with a lysine residue and the substitutions at amino acids corresponding to positions 36 and 37 are with an alanine residue.