Patent ID: 9242011
Filing Date: 2016-01-26
CPC Classification: A61K,A61P,C07K

Claim Text:
1. A compound of wherein Ins represents insulin or a human insulin analogue; M′ represents the thiol reactive group designated M after reaction with a thiol group of Alb (albumin); M represents a Michael acceptor represented by a malimido group, a vinylsulfone or the like, a thiol reactive group represented by iodide, pyridyldisulfide, methoxy- or ethoxycarbonyldisulfide and o-nitrophenyldisulphide; wherein M and M′ are bound, via the linker Z Z is a covalent bond or is selected from —NH—(CH p is 0 or an integer in the range from 1 to 24; q is 0 or an integer in the range from 1 to 24; r is 0 or an integer in the range from 1 to 24; and —C Y is a covalent bond or is selected from —NH—(CH p is 0 or an integer in the range from 1 to 24; q is 0 or an integer in the range from 1 to 24; r is 0 or an integer in the range from 1 to 24; and —C n represents an integer in the range from 1 to 10 o is an integer in the range from 0 to 10; and Alb is selected from the group consisting of ALBAGEN™and human serum albumin.