Patent ID: 9228970
Filing Date: 2016-01-05
CPC Classification: B01L,C12Q,G01N,G05B,Y10T

Claim Text:
1. A bio-sensing device suitable for the detection and/or characterization of target DNA and/or RNA bioparticles, the bio-sensing device comprising a heating element configured to heat using a power, the heating element being suitable for providing thermal denaturation of target DNA and/or RNA bioparticles, a sample holder adapted for receiving a biocompatible substrate having a functionalized surface that is coated with probe DNA and/or RNA to which target DNA and/or RNA duplexes can be attached, the sample holder further being adapted for exposing the biocompatible substrate at one side to the heating element, a first temperature sensor configured to sense a temperature at the side where the biocompatible substrate can be exposed to the heating element and a second temperature sensor configured to sense a temperature at the side opposite thereto with respect to the biocompatible substrate, and a processing means programmed for calculating at least one heat transfer resistivity value based on temperature values obtained with the first temperature sensor and the second temperature sensor and the power for the heating element, the heat transfer resistivity value being defined as ΔT/P, in which P is the power of the heating element and ΔT is the difference between the temperature value of the first temperature sensor and the temperature value of the second temperature sensor, for deriving a characteristic of the target DNA and/or RNA bioparticles from said heat transfer resistivity value.