Patent ID: 9322035
Filing Date: 2016-04-26
CPC Classification: A01K,C07K,C12N

Claim Text:
1. An isolated monovalent IgG4 antibody that binds to a selected antigen, which monovalent antibody comprises a heavy chain, which heavy chain comprises (i) a human VH region, and (ii) a human CH region comprising a hinge region and a CH3 region, wherein the CH region has been modified such that the region corresponding to the hinge region does not comprise any amino acid residues which are capable of forming disulfide bonds with an identical CH region, and wherein the CH3 region has the sequence as set forth in SEQ ID NO: 16, but wherein the CH3 region has been modified so that one of the following amino acid substitutions has been made: Phe (F) in position 273 has been replaced by Ala (A); Phe (F) in position 273 has been replaced by Leu (L); Phe (F) in position 273 has been replaced by Asp (D); Phe (F) in position 273 has been replaced by Thr (T), and a light chain, which light chain comprises (i) a human VL region, and (ii) a human CL region.