Patent ID: 9526782
Filing Date: 2016-12-27
CPC Classification: A61K,A61P,C07K,C12N,C12Q,G01N

Claim Text:
1. A method for treating a joint disease, comprising: administering to a subject in need thereof an inhibitor of the expression of the metal-regulatory transcription factor-1 (MTF1) gene of SEQ ID NO:3 or the activity of the MTF1 protein of SEQ ID NO:4, wherein the joint disease is osteoarthritis, and wherein the inhibitor of the expression of the MTF1 gene is selected from the group consisting of siRNA (small interference RNA), shRNA (short hairpin RNA), miRNA (microRNA), and an antisense oligonucleotide, and wherein the inhibitor of the activity of the MTF1 protein is an antibody.