Patent ID: 9249404
Filing Date: 2016-02-02
CPC Classification: A61P,C12N,C12Y

Claim Text:
1. A modified biologically active recombinant factor X variant comprising a factor X polypeptide, wherein the factor X polypeptide comprises the factor X heavy chain sequence of SEQ ID NO: 2, with the addition of one or more cleavage sites for a protease inserted into the factor X heavy chain sequence between at least one set of amino acids selected from the group consisting of amino acids Ile235 and Val236, amino acids Val236 and Gly237 and amino acids Gly237 and Gly238, wherein the modified factor X variant is activated upon cleavage of the one or more inserted cleavage sites by the protease, and wherein the modified factor X variant has factor X clotting activity.