Patent ID: 9249395
Filing Date: 2016-02-02
CPC Classification: A61K,A61P,C07K,C12N

Claim Text:
1. A particulate delivery vehicle comprising a single-stranded RNA pestivirus replicon lacking essential codons or all codons for one or more structural proteins required for formation of infectious virus, and carrying a foreign gene, wherein the replicon comprises an N PRO gene that is mutated or C-terminally truncated, the replicon cannot prevent type I IFN induction, and an autoproteolytic activity of the N PRO is maintained, wherein the single-stranded RNA pestivirus replicon is encapsulated inside the particulate delivery vehicle to protect the single-stranded RNA replicon against RNase degradation and wherein the particulate delivery vehicle is appropriate to deliver the single-stranded RNA replicon to the cytoplasm of cells for replication and translation of the single-stranded RNA replicon in the cytoplasm.