Patent ID: 9469593
Filing Date: 2016-10-18
CPC Classification: C07C

Claim Text:
1. A process for preparing cinacalcet hydrochloride, comprising charging (R)-1-naphthyl ethylamine (Formula I) and 3-(trifluoromethyl) benzene compound (Formula II) at a molar ratio of 1.0:1 to 5.0:1 in a suitable organic solvent, heating and refluxing until the 3-(trifluoromethyl) benzene compound is completely consumed in presence of an inorganic base, obtaining a mixture containing cinacalcet, obtaining cinacalcet hydrochloride having a formula of from the mixture containing cinacalcet after acidification with hydrochloride and extraction, washing the mixture containing cinacalcet with water to obtain an aqueous layer and an organic layer, separating and removing the aqueous layer, and adding hydrochloric acid to the organic layer to obtain a mixture of the organic layer and the hydrochloric acid layer, heating the mixture of the organic layer and the hydrochloric acid layer to about 40-80° C. until a two-phase system is clear, and separating the two-phase system into the separated organic layer and the separated hydrochloric acid layer, allowing the separated organic layer to cool down to about 0° C.-30° C., and obtaining cinacalcet hydrochloride by crystallizing and filtering, and adjusting pH of the separated hydrochloric acid layer with a second inorganic base to 8 to 14, extracting the separated hydrochloric acid layer with a second organic solvent at 1 to 10 times w/v of the (R)-1-naphthyl ethylamine charged for 1-5 times, combining organic layers from the extraction, and concentrating the combined organic layer to recover the (R)-1-naphthyl ethylamine of formula I, wherein L in Formula II is a halogen, methanesulfonate, p-toluenesulfonate, or triflate.