Patent ID: 9303060
Filing Date: 2016-04-05
CPC Classification: C07J

Claim Text:
1. A method of preparing a thioic acid intermediate of fluticasone propionate, the method comprising: treating Compound 4, 17β-[(N,N-dimethylcarbamoyl)thio]carbonyl-6α,9α-difluoro-11β-hydroxy-16α-methyl-3-oxo-17α-propionyloxyandrosta-1,4-diene in a solution comprising an alcohol and an alkali metal hydroxide, an alkaline-earth metal hydroxide, or a mixture thereof to cleave an amide from Compound 4; treating the solution to separate an aqueous portion; and adding an acid to the aqueous portion to obtain the thioic acid intermediate of fluticasone propionate: