Patent ID: 9470771
Filing Date: 2016-10-18
CPC Classification: A61B,G01N,G01R,G16H

Claim Text:
1. A method of measuring GlycA, an NMR biomarker derived from a measure of composite NMR signal from carbohydrate portions of acute phase reactant glycoproteins containing N-acetylglucosamine and/or N-acetylgalactosamine moieties, comprising: obtaining a composite NMR spectrum of a fitting region of a blood plasma or serum sample of a subject; deconvolving the composite NMR spectrum using a defined deconvolution model with a plurality of subclasses of high density lipoprotein (HDL) components, low density lipoprotein (LDL) components, VLDL (very low density lipoprotein)/chylomicron components, and a plurality of curve fit functions associated with at least a GlycA peak region; and generating a measure of GlycA using the curve fit functions, wherein the GlycA NMR biomarker is derived from NMR signal of the protons of N-acetylglucosamine and N-acetylgalactosamine methyl groups, and wherein the GlycA peak region is centered at 2.00 ppm and the fitting region extends from 1.845 ppm to 2.080 ppm if the sample is at 47+/−0.2 degrees C. in an NMR spectrometer.