Patent ID: 9402888
Filing Date: 2016-08-02
CPC Classification: A61K,C12Y

Claim Text:
1. An immunogenic composition comprising: (a) an adenoviral vector comprising a first expression cassette comprising a first nucleic acid sequence encoding a tumor-specific antigen fused within or to a protein that inhibits an immunoinhibitory pathway operatively linked to an expression control sequence that directs the expression of the fused antigen in a mammalian host cell; and (b) an adenoviral vector comprising a second expression cassette comprising a second nucleic acid sequence encoding fibroblast activation protein (FAP) operatively linked to an expression control sequence directing the expression of FAP in a mammalian host cell, said vectors in a pharmaceutically acceptable carrier suitable for administration to a mammal, and wherein the inhibiting protein is HSV gD, or an antibody or fragment of antibody to PD-1, PD-L1, LAG-1 CTLA-4, BTLA, or CD160.