Patent ID: 9364442
Filing Date: 2016-06-14
CPC Classification: A61K,G01N

Claim Text:
1. A composition for the controlled release of at least one biologically active polypeptide having a molecular weight equal to or greater than 10,000 to a host, comprising the at least one biologically active polypeptide encapsulated in a matrix comprising at least one phase separated, thermoplastic, biodegradable multi-block copolymer, the copolymer being characterized in that: (i) it comprises at least two hydrolysable segments chosen from prepolymer (A) and prepolymer (B), prepolymer (A) having a Tg lower than 37° C. and prepolymer (B) having a Tm of 40° C.-100° C. under human body conditions; (ii) the phase separated copolymer having at least two phase transitions, each of which is related to the corresponding Tg or Tm values of the prepolymers which are comprised in the copolymer; (iii) prepolymer (A) comprising reaction products of cyclic monomers selected from glycolide, lactide, c-caprolactone, δ-valerolactone, trimethylene carbonate, tetramethylenecarbonate, 1,5-dioxepane-2-one, 1,4-dioxane-2-one (para-dioxanone) and/or cyclic anhydrides; and wherein prepolymer (A) contains a segment that is derived from a water soluble polymer derived from a diol, a diamine or a diacid; (iv) prepolymer (B) comprising poly(c-caprolactone) with an Mn of larger than 3000; (v) the segments being linked by a diiosocyanate chain-extender; (vi) the segments are randomly distributed over the polymer chain; and (vii) said copolymer contains poly(ethylene glycol), as a segment of pre polymer (A) and/or as an additional pre polymer, and wherein said poly(ethylene glycol)