Patent ID: 9512155
Filing Date: 2016-12-06
CPC Classification: C07B,C07C,C07D,C07F

Claim Text:
1. A method of asymmetrically synthesizing an α-aryl compound of Formula I: or a pharmaceutically acceptable salt thereof, the method comprising the step of reacting a compound of Formula II with a compound of Formula III in the presence of a palladium catalyst, an activator, a compound of Formula IV, and optionally a solvent, to produce the asymmetric α-aryl compound of Formula I: wherein: * is an asymmetric carbon atom; the compound of Formula III is the (E)- or (Z)—OSiR the palladium catalyst is selected from PdMe the solvent is an aromatic solvent; Ar is a substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl group, which is optionally independently substituted with 1, 2 or 3 R R R each R R R R each R R R