Patent ID: 9394378
Filing Date: 2016-07-19
CPC Classification: C08B

Claim Text:
1. Process for the production of chondroitin sulphate, wherein N-acetyl-galactosamine residues sulphated at 4- or 6-positions are present on the same polysaccharide chain, said process comprising: a) preparing 4,6-benzylidene derivative on residues of chondroitin N-acetyl-galactosamine in acid form; b) acylating hydroxyls in position 2 and 3 of glucuronic acid residues; c) oxidative opening the benzylidene cycle; d) sulphating hydroxyls in position 4 or 6 of the N-acetyl-galactosamine residues; e) eliminating the benzoyl protective group from the 4- or 6-positions of the N-acetyl-galactosamine residues, and of the acyl protective groups on the 2 and 3 hydroxyls of the glucuronic acid residues; f) purifying the chondroitin 4 or 6 sulphate thus obtained wherein said chondroitin sulphate has a molecular weight of between 5 and 50 KDa and the N-acetyl-galactosamine residues on each polysaccharide chain are sulphated at the 4- or 6-positions in a percentage ranging between 20 and 95%.