Patent ID: 9333270
Filing Date: 2016-05-10
CPC Classification: A61K,A61P,C07D,G01N

Claim Text:
1. A method of optical imaging of a biological tissue that expresses a folate receptor, the method comprising: (a) contacting the biological tissue with a composition comprising a compound having the formula: or a pharmaceutically acceptable salt thereof, or isotopes thereof, wherein: X is an single amino acid or a single amino acid derivative thereof, wherein the single amino acid or single amino acid derivative contains an —OH, —NH Y is a dye that has a fluorescence excitation and emission spectra in the near infra red range, wherein Y is represented by the formula: wherein, X′ is independently selected from the group consisting of O, S, N and C, and R′ is independently selected from the group consisting of CH and the compound maintains or enhances the fluorescence of the dye, Y; (b) allowing time for the compound in the composition to distribute within the biological target; (c) illuminating the tissue with an excitation light of a wavelength absorbable by the compound; and (d) detecting the optical signal emitted by the compound.