Patent ID: 9447410
Filing Date: 2016-09-20
CPC Classification: A61K,A61P,C07K,C12N,C40B

Claim Text:
1. A phage particle displaying on its surface a dimeric T-cell receptor (dTCR) polypeptide pair, wherein the dTCR polypeptide pair comprises a first polypeptide wherein a TCR α or δ chain variable domain sequence is fused to N terminus of a TCR αchain constant domain extracellular sequence, and a second polypeptide wherein a TCR β or γ chain variable domain sequence is fused to N terminus of a TCR β chain constant domain extracellular sequence, wherein the first and second polypeptides are linked by a disulfide bond which corresponds to a native inter-chain disulfide bond present in native dimeric αβ TCRs.