Patent ID: 9415011
Filing Date: 2016-08-16
CPC Classification: A61K,A61P

Claim Text:
1. A method for treatment of liver cancer and inhibition of metastasis of liver cancer, comprising administrating to a subject in need a therapeutically effective amount of a pharmaceutical composition comprising a CXC-chemokine-receptor 4(CXCR4)-targeted nanoparticle, the nanoparticle comprises: a core comprising an anti-angiogenesis drug or a nucleotide having an anti-angiogenic effect; a lipid carrier encapsulating the core; and a CXCR4-targeted molecule attached to the surface of the lipid carrier, wherein the CXCR4-targeted molecule specifically delivers the nanoparticle to a hepatocellular carcinoma and sensitizes the hepatocellular carcinoma to the anti-angiogenesis drug or nucleotide having an anti-angiogenic effect to provide a synergistic effect of the anti-angiogenesis drug or the nucleotide having the anti-angiogenic effect to the hepatocellular carcinoma.