Patent ID: 9435870
Filing Date: 2016-09-06
CPC Classification: G01N,G01R,G16B,G16H

Claim Text:
1. A method of determining a subject's risk of having and/or developing coronary heart disease, comprising: conducting Nuclear Magnetic Resonance to obtain concentration measurements of small and large High Density Lipoprotein subclass particles from a single in vitro blood plasma or serum sample of a subject; and programmatically numerically adjusting at least one of the obtained small and large High Density Lipoprotein subclass particle concentration measurements of the single in vitro blood plasma and/or serum sample based on a predetermined mathematical model with at least one weighting factor that is multiplied to increase or decrease the small and/or large High Density Lipoprotein subclass particle concentration measurements, wherein the at least one weighting factor reflects predicted CHD risk for the weighted High Density Lipoprotein subclass, to yield a High Density Lipoprotein risk number that can be greater than a summation of an actual, unadjusted total High Density Lipoprotein particle concentration measurement, to thereby determine the subject's High Density Lipoprotein based risk of coronary heart disease.