Patent ID: 9291692
Filing Date: 2016-03-22
CPC Classification: A61B,G01R

Claim Text:
1. A method of assessing the blood-brain barrier recovery curve, comprising: providing an ultrasound contrast agent to a subject; applying an ultrasound to a brain target area of the subject to open the blood-brain barrier; applying the ultrasound to the brain target area of the subject at different time points with a dynamic contrast-enhanced MRI (DCE-MRI); using DCE-MRI for the whole brain imaging to obtain DCE-MRI image signals of brain permeability on the target and non-target area at different time points; analyzing the obtained DCE-MRI image signals and using general kinetic model (GKM) to calculate the permeability constant K calculating the permeability constant K and to obtain a blood-brain barrier recovery curve;