Patent ID: 9255176
Filing Date: 2016-02-09
CPC Classification: A61K,A61P,C08G,C08J

Claim Text:
1. A method of modifying a surface on a polymeric substrate selected from the group consisting of solid synthetic polymers, solid natural polymers, and hydrogels, comprising the steps of: fabricating an article from a polymeric body composed of polymeric molecules having first reactive endgroups tethered to surface active spacers as part of polymer chain ends, which surface active spacers comprise endgroups on said polymeric molecules and forming a surface of said first reactive endgroups linked to surface active spacers on said polymeric body, said polymeric body bearing said first reactive endgroup being an isocyanate-terminated polyurethane; contacting the surface of said polymeric body with a compound containing at least one third reactive endgroup and at least one fourth reactive endgroup to react said at least one third reactive endgroup with a first reactive endgroup and thereby link said at least one fourth reactive endgroup to the polymeric molecules by a covalent or ionic bond; and contacting the resulting surface of said polymeric body with a compound containing at least one second reactive group and at least one surface modifying moiety, selected from the group consisting of sugars, peptides, and proteins, to react said at least one second reactive endgroup with said at least one fourth reactive endgroup and thereby link said at least one surface modifying moiety to one of said polymeric molecules by a covalent, coordination, or ionic bond, wherein said first and third reactive endgroups and said second and fourth reactive endgroups are respectively selected to be a pair of reactive groups selected from the group consisting of a hydroxyl group and an isocyanate group and a alkyne group and an azido group, and wherein said first reactive endgroups are spontaneously brought to the surface of said article during the fabrication thereof by a fabrication method that comprises thermal forming or solvent-based processing, the polymeric substrate with a modified surface having the formula wherein R is a sugar, peptide, or protein moiety and Polymer is a polyurethane.