Patent ID: 9512412
Filing Date: 2016-12-06
CPC Classification: A61K,A61P,C07K,C12N,C12P,C12Y

Claim Text:
1. A nucleic acid molecule coding for a mutant polypeptide which comprises a mutated HBV polymerase domain with an internal deletion that functionally disrupts the polymerase activity, wherein said internal deletion is of at least 4 amino acid residues and at most 30 amino acid residues, said mutated polymerase domain comprising: the amino acid sequence shown in SEQ ID NO:1 but lacking at least the Tyr residue in position 203, the Met residue in position 204, the Asp residue in position 205, the Asp residue in position 206, the Val residue in position 207, the Val residue in position 208, and the Leu residue in position 209.