Patent ID: 9500629
Filing Date: 2016-11-22
CPC Classification: G01N

Claim Text:
1. A chromatogram data processing method for coordinating a time axis of a reference chromatogram serving as a standard so that a time axis of a target chromatogram is aligned with the time axis of the reference chromatogram, comprising: a data receiving step for receiving target chromatogram data from a chromatograph device including a separation part for separating various components contained in a sample in the time direction and a detector for detecting a sample with separated components, a linear correction step for eliminating linear time variation from the target chromatogram using peaks detected in the reference chromatogram and the target chromatogram; a coarse searching step for searching for candidates for a correspondence relationship between the reference chromatogram and the target chromatogram in a coarse stage by selecting peaks for the respective reference chromatogram and target chromatogram, the selected peaks being selected based on intensity information for each of the respectively detected peaks in the target chromatogram and the reference chromatogram after linear correction by said linear correction step, and determining the candidates in the coarse stage by executing matching by a dynamic programming algorithm focusing on the retention times of the selected peaks, wherein peaks not selected by said selecting are eliminated from consideration during said matching; a fine searching step for searching for a correspondence relationship between the reference chromatogram and the target chromatogram in a fine stage by adding the peaks that were eliminated from consideration in said coarse searching step and then executing matching by a dynamic programming algorithm focusing on the retention times of peaks corresponding to the candidates determined in said coarse searching step and the peaks that were eliminated from consideration in said coarse searching step, to determine the correspondence relationship by verifying accuracy of the candidates determined in said coarse searching step and determining an appropriate correspondence for the peaks that were eliminated from consideration in said coarse searching step; and a correction processing step for correcting the time axis of the target chromatogram so as to align the time axis of the target chromatogram with the time axis of the reference chromatogram based on the correspondence relationship between the reference chromatogram and the target chromatogram determined in said fine searching step.