Patent ID: 9339524
Filing Date: 2016-05-17
CPC Classification: A23L,A23V,A61K,A61P,C07K

Claim Text:
1. A method of reducing the progression of atherosclerosis and lowering blood cholesterol, comprising administering to a patient affected with atherosclerosis and high blood cholesterol a hydrolysis product of a collagen containing collagen tripeptides Gly-X-Y, wherein Gly-X-Y denotes an amino acid sequence in which X and Y denote amino acid residues other than Gly, in an amount sufficient to reduce total blood cholesterol and at least one parameter selected from the group consisting of (i) migration of human aortic smooth muscle cells (AoSMC), (ii) plaque development and (iii) proliferating cell nuclear antigen (PCNA)-positive ratio in AoSMC in order to reduce the progression of atherosclerosis in the patient, wherein the collagen tripeptide hydrolysis product comprises Gly-Ala-Asp, Gly-Ala-Lys, Gly-Ala-Val, Gly-Pro-Gln, Gly-Pro-Met, Gly-Pro-Ile, Gly-Pro-Thr, Gly-Pro-Val, Gly-Ser-Hyp, Gly-Lys-Asp, Gly-Ala-Ala, Gly-Pro-Hyl, Gly-Leu-Hyp, Gly-Ala-Arg, Gly-Ala-Ser, Gly-Ala-Hyp, Gly-Gln-Glu, Gly-Glu-Gln, Gly-Pro-Ser, Gly-Pro-Lys, Gly-Pro-Ala, Gly-Pro-Pro, Gly-Pro-Arg and Gly-Pro-Hyp, and wherein the amount sufficient to reduce total blood cholesterol and the one parameter selected from the group consisting of: (i) migration of AoSMC; (ii) plaque development; and (iii) PCNA-positive ratio in AoSMC is from 10 to 1000 mg per kg of body weight.