Patent ID: 9468613
Filing Date: 2016-10-18
CPC Classification: A61K,A61P,C07C

Claim Text:
1. A method comprising: administering to a subject an amount of a doxorubicin toxicity-reducing adjuvant effective to reduce toxicity of a doxorubicin active agent, wherein said doxorubicin toxicity-reducing adjuvant is a nitrone compound of formula (II): or a pharmaceutically acceptable salt thereof, or a spatial isomer thereof: wherein: R is hydrogen or a disulfide conjugate; L is —[C(R X′ is selected from the group consisting of no atom, NR Cy is selected from the group consisting of substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted cycloheteroalkyl, bicycloalkenyl, bicycloheteroalkenyl, bicycloaryl, or bicycloheteroaryl ring; R R R R one of R