Patent ID: 9260454
Filing Date: 2016-02-16
CPC Classification: A61P,C07D

Claim Text:
1. A compound of the formula I, in any of its stereoisomeric forms or a mixture of stereoisomeric forms in any ratio, or a pharmaceutically acceptable salt thereof, wherein X is selected from the series consisting of ═N— and ═N(O)—; R1, R2 and R3 are independently of one another selected from the series consisting of hydrogen, halogen, (C R4 is selected from the series consisting of hydrogen, (C R5, R6 and R7 are independently of one another selected from the series consisting of hydrogen, (C R8 is selected from the series consisting of halogen, (C R10 is selected from the series consisting of hydrogen, (C R11 is selected from the series consisting of (C or the groups R10 and R11, together with the nitrogen atom carrying them, form a 4-membered to 12-membered, monocyclic or bicyclic, saturated or partially unsaturated heterocycle which, in addition to the nitrogen atom carrying R10 and R11, comprises 0, 1 or 2 further ring heteroatoms selected from the series consisting of nitrogen, oxygen and sulfur, which is optionally substituted on ring carbon atoms by one or more identical or different substituents R30, and which is optionally substituted on further ring nitrogen atoms by one or more identical or different substituents R40; R12 is selected from the series consisting of (C R13 is selected from the series consisting of hydroxy, (C R14 is selected from the series consisting of fluorine, (C R15, R16 and R18 are independently of one another selected from the series consisting of hydrogen, (C R17 is selected from the series consisting of (C R19 is selected from the series consisting of halogen, (C R20, R21 and R22 are independently of one another selected from the series consisting of hydrogen and (C R30 is selected from the series consisting of fluorine, (C R31, R32, R33, R34 and R35 are independently of one another selected from the series consisting of hydrogen and (C R36 is selected from the series consisting of fluorine, (C R40 is selected from the series consisting of (C R41 is selected from the series consisting of (C R42 is selected from the series consisting of hydroxy and R65-N(R66)-; R43 is selected from the series consisting of halogen, (C R44 is selected from the series consisting of halogen, (C R45 is selected from the series consisting of (C R46 is selected from the series consisting of hydroxy and R79-N(R80)-; R47 is selected from the series consisting of halogen, (C R48 is selected from the series consisting of halogen, (C R49 and R51 are independently of one another selected from the series consisting of hydrogen, (C R50 and R52 are independently of one another selected from the series consisting of hydrogen, (C R60, R61, R62, R63, R64, R65, R66, R67, R68, R69, R70, R71, R72, R73, R76, R78, R79, R80, R81, R82, R83 and R84 are independently of one another selected from the series consisting of hydrogen and (C R74 is selected from the series consisting of fluorine and (C R75 is selected from the series consisting of hydrogen, (C R77 is selected from the series consisting of (C Het1 is a monocyclic, 4-membered to 7-membered, saturated, partially unsaturated or aromatic heterocycle which comprises 1, 2 or 3 identical or different ring heteroatoms selected from the series consisting of nitrogen oxygen and sulfur, and which is bonded via a ring carbon atom; Het2 is a monocyclic, 4-membered to 7-membered, saturated heterocycle which comprises 1 or 2 identical or different ring heteroatoms selected from the series consisting of nitrogen, oxygen and sulfur; Het3 is a monocyclic or bicyclic, 4-membered to 12-membered, saturated, partially unsaturated or aromatic heterocycle which comprises 1, 2 or 3 identical or different ring heteroatoms selected from the series consisting of nitrogen, oxygen and sulfur; Het4 is a monocyclic, 4-membered to 7-membered, saturated heterocycle which comprises a ring nitrogen atom via which Het4 is bonded, and 0 or 1 further ring heteroatom selected from the series consisting of nitrogen, oxygen and sulfur; wherein all phenyl groups are optionally substituted by one or more identical or different substituents selected from the series consisting of halogen, (C wherein all cycloalkyl groups, independently of any other substituents which can be present on a cycloalkyl group, are optionally substituted by one or more identical or different substituents selected from the series consisting of fluorine and (C wherein all alkyl groups, independently of any other substituents which can be present on an alkyl group, are optionally substituted by one or more fluorine substituents; with the proviso that the compound of the formula I is not 3-oxo-3H-isothiazolo[5,4-b]pyridine-2-carboxylic acid diethylamide.