Patent ID: 9446029
Filing Date: 2016-09-20
CPC Classification: A61K,A61P

Claim Text:
1. A method of improving visceral analgesia during a visceral surgery in an anesthetized canine subject in need thereof, the method comprising: administering to the subject an amount of an inhalational general anesthetic selected from the group consisting of isoflurane, enflurane, halothane, sevoflurane, or desflurane; parenterally or orally administering to the subject 0.1 mg/kg to 50 mg/kg of the subject's body weight of a composition comprising (7R,8S)-N-[(5-tert-Butyl-2-methoxyphenyl)methyl]-7-[di(phenyl)methyl]-1-azabicyclo[2.2.2]octan-8-amine or a pharmaceutically acceptable salt thereof, before or during administration of the inhalational general anesthetic to the subject; and conducting the visceral surgery, wherein administering the inhalational general anesthetic comprises administering a reduced amount of the general anesthetic relative to a subject not administered the NK-1 receptor antagonist composition, the reduced amount determined by a reduction of at least about 24% in the minimum alveolar concentration (MAC) of the inhalational anesthetic sufficient for the subject to achieve a surgical plane of anesthesia.