Patent ID: 9254339
Filing Date: 2016-02-09
CPC Classification: A61K,A61P,C07K,C08G

Claim Text:
1. A polymeric scaffold of Formula (Ia) useful to conjugate with an antibody: wherein: the scaffold comprises poly(l-hydroxymethylethylene hydroxymethyl-formal) (PHF) having a molecular weight ranging from 2 kDa to 40 kDa; each occurrence of D is independently a vinca alkaloid; L each occurrence of is independently a first linker that contains a biodegradable bond so that when the bond is broken, D is released in an active form for its intended therapeutic effect; and the in between L D1 and D denotes direct or indirect attachment of D to L D1 ; each occurrence of is independently a second linker not yet connected to an antibody, in which L P2 is a moiety containing a functional group that is yet to form a covalent bond with a functional group of the antibody, and the between L D1 and L P2 denotes direct or indirect attachment of L P2 to L D1 , and each occurrence of the second linker is distinct from each occurrence of the first linker; m is an integer from 1 to 300, m m m the sum of m, m