Patent ID: 9273333
Filing Date: 2016-03-01
CPC Classification: C07C,C07D,C07F,C12P,Y02P

Claim Text:
1. A process for the preparation of compound of Formula-II comprising the steps of: a) enzymatic enantioselective amidation of compound of Formula-III in presence of suitable enzyme to get amide compound of Formula-IV wherein R 2 is C 1 -C 5 alkyl or aryl or arylalkyl group and wherein said suitable enzyme is Candida Antartica lipase; b) transesterification of compound of Formula-IV into compound of Formula-V wherein R 3 is C 1 -C 5 alkyl or aryl or arylalkyl group with proviso that R 3 is different than R 2 of Formula-IV; c) protecting the hydroxy group with suitable hydroxy protecting group to get compound of Formula-VI wherein X is a suitable protecting group; d) converting the compound of Formula-VI into compound of Formula-VII; and e) converting compound of Formula-VII into compound of Formula-II wherein R 1 is carboxyl protecting group and X is defined above.