Patent ID: 9458111
Filing Date: 2016-10-04
CPC Classification: C07D

Claim Text:
1. A process of preparing a substituted urea compound of Formula IIa: or a pharmaceutically acceptable salt or ester thereof, the process comprising the reaction of a carbamate of Formula IIa′: with a secondary amine of the formula R1R2NH, wherein: R1 is C R2 is selected from aryl, heteroaryl, heterocyclyl, and C wherein, when the optional substitution of R2 is selected from the group consisting of C R5 is selected from H, R5a, halogen, OH, OR5a, OCOR5a, SH, SR5a, SCOR5a, NH R6 is selected from aryl, heteroaryl, heterocyclyl, and C wherein, when the optional substitution of R6 is selected from the group consisting of C R8 is selected from H, R5a, halogen, OH, OR5a, OCOR5a, SH, SR5a, SCOR5a, NH J is H or a nitro group and is attached at any available position on the phenyl ring.