Patent ID: 9486512
Filing Date: 2016-11-08
CPC Classification: A61K,A61P,B82Y

Claim Text:
1. A biopsy-free method for producing a processed tumor antigen in situ comprising administering to a subject diagnosed with a cancer a porous 3-dimensional scaffold, said scaffold comprising (a) a first zone comprising a chemoattractant of cancer cells and a cytotoxicity-inducing composition, and (b) a second zone comprising an immune cell recruitment composition, wherein said second zone does not comprise a cytotoxicity-inducing composition; and maintaining said scaffold in situ for a time period sufficient to accumulate a circulating cancer cell to yield a cancer cell-containing scaffold, and contacting said cytotoxicity-inducing composition in said first zone with a cytotoxic or cytolytic element to specifically disrupt said cancer cell, thereby producing a processed tumor antigen.