Patent ID: 9278132
Filing Date: 2016-03-08
CPC Classification: A61K,A61P

Claim Text:
1. An ophthalmic pharmaceutical composition comprising an oil-in-water emulsion that comprises: (a) a first polymer comprising a polymer or copolymer of carboxyvinyl monomers; the first polymer being present at a concentration in the range from about 0.01 to about 1 percent by weight of the composition; (b) a second polymer comprising a polyanionic polysaccharide selected from the group consisting of alginic acid, hyaluronic acid, salts of alginic acid or hyaluronic acid, and glucuronoxylomannan extracted from Tremella fuciformis mushroom; the second polymer being present at a concentration in the range from about 0.01 to about 1 percent by weight of the composition; (c) a caprylic acid/capric acid medium-chain triglyceride present at a concentration in the range from about 0.01 to about 1 percent by weight of the composition; (d) a non-ionic surfactant present at a concentration in the range from about 0.01 to about 1 percent by weight of the composition; and (e) water; wherein the emulsion is stable on storage but breaks up into separate aqueous and oil phases when diluted with simulated tear or subjected to shear stress; and wherein the composition has a viscosity in the range from about 2 to about 1000 cP.