Patent ID: 9365626
Filing Date: 2016-06-14
CPC Classification: A61K,A61P,C07K

Claim Text:
1. A method of inhibiting Factor Xa and inhibiting elastase and/or cathepsin G in a subject, the method comprising administering to the subject a composition comprising a polypeptide comprising a Kunitz domain and one or more pharmaceutically acceptable carriers, wherein the polypeptide comprising a Kunitz domain consists of an isolated simukunin polypeptide comprising an amino acid sequence at least 95% identical to SEQ ID NO:3 or a fragment thereof, wherein a fragment thereof comprises a Kunitz domain comprising disulfide bonds between cysteine residues C5 to C55, C14 to C38, and C30 to C51 of SEQ ID NO:3 and the reaction site loop (RSL) amino acid residues 12 to 17 of SEQ ID NO:3.