Patent ID: 9403809
Filing Date: 2016-08-02
CPC Classification: C07D

Claim Text:
1. A process for preparation of raltegravir of formula (I) comprising; (a) reacting 2-amino-2-methylpropanenitrile with oxadiazole carbonyl chloride in presence of a base to give N-(2-cyanopropan-2-yl)-5-methyl-1,3,4-oxadiazole-2-carboxamide of formula (II), (b) treating N-(2-cyanopropan-2-yl)-5-methyl-1,3,4-oxadiazole-2-carboxamide of formula (II) with hydroxyl amine derivative of formula (III) to give compound of formula (IV), (c) treating compound of formula (IV) with dialkyl acetylene dicarboxylate and isolating compound of formula (V), wherein, R′ is methyl, (d) coupling compound of formula (V) with p-fluorobenzyl amine and isolating compound of formula (VIa) or raltegravir of formula (I), and if compound of formula (VIa) is isolated in step (d) then methylating the compound of formula (VIa) with a methylating agent to give raltegravir, formula (I).