Patent ID: 9233078
Filing Date: 2016-01-12
CPC Classification: A61K

Claim Text:
1. A pharmaceutical composition comprising nanoparticles, said nanoparticles consisting of: (a) a poorly water soluble drug having a solubility in water of less than 5 mg/mL over the pH range of 6.5 to 7.5 at 25° C., at least 90 wt % of said drug in said nanoparticles being non-crystalline; (b) a poorly aqueous soluble non-ionizable polymer selected from the group consisting of ethylcellulose, cellulose acetate, cellulose propionate, cellulose butyrate, and cellulose acetate butyrate; and (c) an amine-functionalized methacrylate copolymer; wherein said nanoparticles comprise a core and said core comprises said drug and said non-ionizable polymer; wherein said nanoparticles have an average diameter of less than 500 nm; and said drug, said non-ionizable polymer, and said amine-functionalized methacrylate copolymer collectively constitute at least 80 wt % of said nanoparticles.