Patent ID: 9402845
Filing Date: 2016-08-02
CPC Classification: A61K,A61M,A61P

Claim Text:
1. A method for treating or providing prophylaxis against a pulmonary infection in a patient in need thereof, comprising: administering to the lungs of the patient via an inhalation delivery device, a pharmaceutical formulation comprising a mixture of free quinolone antibiotic agent, a quinolone antibiotic agent encapsulated in a plurality of liposomes, and a pharmaceutical excipient, wherein the formulation is a solution or a suspension, the ratio by weight of free quinolone antibiotic agent to the encapsulated quinolone antibiotic agent is between about 1:10 and about 10:1 and the lipid component of the plurality of liposomes consists of electrically neutral lipids, wherein the pharmaceutical formulation is administered as an aerosolized pharmaceutical formulation, and the aerosolized pharmaceutical formulation comprises free quinolone antibiotic agent in an amount effective to provide immediate bactericidal activity against the pulmonary infection and liposomal encapsulated quinolone antibiotic agent in an amount effective to provide sustained bactericidal activity against the pulmonary infection.