Patent ID: 9415086
Filing Date: 2016-08-16
CPC Classification: A61K,A61P,G01N

Claim Text:
1. A method of inhibiting proliferation of cancer cells that overexpress EphA2 receptor proteins comprising: administering to the cancer cells of an individual an amount of an agonist of EphA2 receptor protein effective to inhibit the cancer cells' growth, migration, and/or proliferation, the agonist comprising a small molecule, the small molecule having a general formula A-L-B, wherein A and B are independently selected from aryl, and L is selected from C 1-12 alkyl and —C 1-6 alkyl-amino-C 1-6 alkyl- and a molecular weight of about 50 daltons to about 2500 daltons, and stimulating phosphorylation of tyrosine of EphA2 in an in vitro assay, wherein the cancer cells comprise lung cancer cells.