Patent ID: 9387166
Filing Date: 2016-07-12
CPC Classification: A61K,A61P

Claim Text:
1. A multi-particulate controlled-release oral dosage form for use in the treatment of chronic pain by administration of oxycodone once a day, comprising a plurality of substrates comprising oxycodone or a pharmaceutically acceptable salt or solvate thereof, each substrate comprising a release-control substance for controlling the release of oxycodone of the salt or solvate thereof, wherein each substrate comprises an oxycodone-containing core and a release-control layer containing the release-control substance for controlling the release of oxycodone from the substrate, wherein at steady state the oral dosage form provides a mean C wherein the core comprises a layer comprising oxycodone coated on an inert core and/or wherein the release control substance is a polymer selected from the group consisting of cellulose acetate phthalate, polyvinyl pyrrolidone, polyvinyl alcohol, polyvinyl acetate, polyvinyl chloride, nylon, polyamide, polyethylene oxide, polylactide-co-glycolide and mixtures thereof, and ethyl cellulose; and wherein the plurality of substrates is contained in an external phase of at least one pharmaceutically acceptable excipient, wherein the release-control layer comprises 40 to 80 wt. % release control substance, 1 to 25 wt. % pore builder 1 to 25 wt. % plasticiser, and optionally 5 to 30 wt. % glidant based on the total weight of the release-control layer.