Patent ID: 9359332
Filing Date: 2016-06-07
CPC Classification: A61K,A61P,C07D

Claim Text:
1. A process for preparing a compound of the formula 8, or a salt thereof, wherein: E wherein the process comprises (a) O-alkylating a compound of formula 7, in the presence of a solvent and a base, wherein R is an N-protecting group that is tert-butoxycarbonyl, carbobenzyloxy, allyloxycarbonyl, acetyl, trifluoroacetyl, benzyl or p-toluenesulfonyl, and R′ is H or an O-protecting group that is p-toluenesulfonyl, methanesulfonyl, trifluoromethanesulfonyl or 2-mesitylsulfonyl, to provide wherein R is the N-protecting group that is tert-butoxycarbonyl, carbobenzyloxy, allyloxycarbonyl, acetyl, trifluoroacetyl, benzyl or p-toluenesulfonyl; (b) deprotecting the compound formed in (a) to provide (c) N-methylating the compound formed in (b) to provide the compound of formula 8,  and (d) optionally converting the compound of formula 8 into the salt of the compound of formula 8.