Patent ID: 9504686
Filing Date: 2016-11-29
CPC Classification: A61K,A61P,C07D,C07F

Claim Text:
1. A method of inhibiting one or both of ERK1 and ERK2, or a mutant thereof, comprising the step of contacting the one or both of ERK1 and ERK2, or a mutant thereof, with a compound of formula VIII: or a pharmaceutically acceptable salt thereof, wherein: Ring A is an optionally substituted group selected from phenyl, a 3-8 membered saturated or partially unsaturated monocyclic carbocyclic ring, a 4-7 membered monocyclic heterocyclic ring having 1-2 heteroatoms independently selected from nitrogen, oxygen, or sulfur, a 5-6 membered monocyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or Ring A is selected from R L is a covalent bond, —C(O)—, —N(R)C(O)—, or a bivalent C each R each R each R each R is independently hydrogen or an optionally substituted group selected from C two R groups on the same nitrogen are taken together with the nitrogen atom to which they are attached to form a 4-7 membered heterocyclic ring having 0-2 additional heteroatoms independently selected from nitrogen, oxygen, or sulfur, or a 4-7 membered heteroaryl ring having 0-4 additional heteroatoms independently selected from nitrogen, oxygen, or sulfur; Cy is an optionally substituted 5-6 membered monocyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or an optionally substituted 4-7 membered saturated or partially unsaturated heterocyclic ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur; R each R′ is independently hydrogen or an optionally substituted C R″ is hydrogen or —OR; and m and p are each independently 0-4.