Patent ID: 9371348
Filing Date: 2016-06-21
CPC Classification: A61P,C07H,C12N

Claim Text:
1. A photoactive oligonucleotide conjugate having the structure: wherein the X component is an antisense oligonucleotide of between 15 and 50 nucleotides in length; the Z component is a sense oligonucleotide that includes a sequence complementary to a first portion of at least 10 consecutive nucleotides of said antisense oligonucleotide; and the Y component is a photocleavable linker covalently attached therebetween, wherein the antisense oligonucleotide has a second portion of at least 5 consecutive nucleotides that is not complementary to the sense oligonucleotide and/or the antisense oligonucleotide is at least 5 nucleotides longer than the sense oligonucleotide, and wherein cleavage of said photocleavable linker results in a lower melting temperature (T m ) of the antisense oligonucleotide to the sense oligonucleotide of between about 20 to 50° C. of the cleaved conjugate relative to the uncleaved conjugate.