Patent ID: 9375429
Filing Date: 2016-06-28
CPC Classification: A61K

Claim Text:
1. A method of increasing dextromethorphan plasma levels in a human being that is an extensive metabolizer of dextromethorphan in need of treatment with dextromethorphan, comprising co-administering a) erythrohydroxybupropion or bupropion with b) dextromethorphan to the human being once or twice a day for at least eight consecutive days, wherein the daily dose of dextromethorphan is about 40 mg to about 600 mg, and co-administering erythrohydroxybupropion or bupropion with dextromethorphan results in an AUC 0-12 of dextromethorphan that, on the eighth day, is at least about 20 times the AUC 0-12 that would be achieved by administering the same amount of dextromethorphan without erythrohydroxybupropion or bupropion for eight consecutive days.