Patent ID: 9289409
Filing Date: 2016-03-22
CPC Classification: A61K,A61P

Claim Text:
1. An implantable drug depot for reducing or treating pain and/or inflammation in a patient in need of such treatment, the implantable drug depot comprising sulindac or a pharmaceutically acceptable salt thereof in an amount from about 20 wt. % to about 40 wt. % based on the weight of the drug depot, and at least one biodegradable polymer comprising poly (lactic-co-glycolic acid) capable of releasing the sulindac or a pharmaceutically acceptable salt thereof for at least 3 days, wherein the at least one biodegradable polymer has an inherent viscosity of from 0.45 dL/g to 0.8 dL/g and the drug depot has a surface that releases a burst dose of sulindac or a pharmaceutically acceptable salt thereof in an amount of 10% to 20% by weight based on the total weight of the sulindac or pharmaceutically acceptable salt thereof in the drug depot within 72 hours and the drug depot comprises an adherent gel that stiffens after delivery to a target site having a pre-dosed modulus of elasticity of about 5×10 4 dynes/cm 2 to about 1×10 5 dynes/cm 2 and a post-dosed modulus of elasticity in the range of about 2×10 5 dynes/cm 2 to about 5×10 5 dynes/cm 2 and the drug depot comprises magnesium carbonate, and the drug depot further comprises a plasticizer comprising mPEG in an amount of from about 0.05 wt. % to about 20 wt. %.