Patent ID: 9238011
Filing Date: 2016-01-19
CPC Classification: A61K,A61L,C08L

Claim Text:
1. A wet spun microfiber composition comprising at least one polymer wherein the composition comprises: a porous polymeric microstructure obtained by solvent induced crystallization (SINC), wherein the polymer is at least one selected from: poly-1-lactic acid (PLLA), poly-lactic-co-glycolide (PLGA), polyvinylpyrrolidone (PVP); and further comprises at least one encapsulated therapeutic agent, the polymer is dissolved in an organic solvent and the therapeutic agent is dispersed with the polymer in the organic solvent to produce a polymer-therapeutic agent solution, and the polymer-therapeutic agent solution is wet spun by extrusion in a non-solvent bath, provided that the non-solvent bath is not water, to obtain the wet spun microstructure; wherein the therapeutic agent is located in the microstructure and is controllably releasable from the composition, and wherein following evaporation of the solvent and the non-solvent the microfiber composition has a degree of crystallinity at least 10% greater than that of control polymer prior to wet spinning.