Patent ID: 9358219
Filing Date: 2016-06-07
CPC Classification: A61K,A61P

Claim Text:
1. A pharmaceutical composition comprising an active ingredient dissolved in an essentially non-aqueous carrier system comprising volatile and non-volatile components, in which the volatile component comprises a volatile non-solvent for the active ingredient and a volatile solvation additive for the non-solvent and the non-volatile component comprises a non-volatile non-solvent and optionally a non-volatile solvent for the active ingredient, the volatile and non-volatile non-solvents comprising silicone fluids of respectively different viscosity, wherein the pharmaceutical composition contains, in percentages by weight, from 0.1 to 15% of local anaesthetic as the active ingredient; from 2 to 15% of the volatile solvation additive; from 65 to 90% of a silicone volatile non-solvent; from 1.0 to 20% of the non-volatile non-solvent and optionally up to 10% of the non-volatile solvent, wherein the volatile solvation additive comprises a lower alcohol containing up to five carbon atoms, the volatile non-solvent comprises a linear and/or cyclic silicone, and the non-volatile non-solvent comprises a silicone oil, wherein the active ingredient has a concentration close to the saturation level whereby, in use on application to the body and as the volatile components evaporate, the residual phase becomes super-saturated to provide a continuing driving force for absorption of an effective amount of active ingredient through the skin as the volatile components continue to evaporate, wherein the non-volatile solvent and non-volatile non-solvent are totally miscible, including in the residual phase, when the non-volatile solvent is present in the composition, and wherein the composition is single-phase, including in the residual phase.