Patent ID: 9523844
Filing Date: 2016-12-20
CPC Classification: G01N,G02B,G06K,G06T,H04N

Claim Text:
1. A system for creating a contiguous digital image of a portion of a fluorescence microscope sample, the system comprising: a motorized stage configured to support a fluorescence microscope sample and move the fluorescence microscope sample at a substantially constant velocity; an illumination source configured to apply oblique illumination to the fluorescence microscope sample on the motorized stage, wherein the illumination source comprises a light source configured to provide excitation light to a portion of the fluorescence microscope sample via an illumination path while the fluorescence microscope sample on the motorized stage is moving at substantially constant velocity; a macro camera configured to capture an image of the fluorescence microscope sample on the motorized stage during oblique illumination; an excitation filter in the illumination path; a time delay integration (TDI) line scan camera comprising a plurality of linear sensor arrays configured to generate a digital image stripe of a portion of the fluorescence microscope sample on the motorized stage while the sample is moving at substantially constant velocity; an objective lens positioned in an optical path between the fluorescence microscope sample on the motorized stage and the TDI line scan camera; an emission filter in the optical path; and at least one processor configured to assemble a plurality of digital image stripes, corresponding to a plurality of stripe regions of the fluorescence microscope sample, generated by the TDI line scan camera, into a contiguous digital image of at least a portion of the fluorescence microscope sample, wherein the plurality of digital image stripes are generated by