Patent ID: 9347051
Filing Date: 2016-05-24
CPC Classification: A61K,A61P,C12N,C12Y

Claim Text:
1. A biologically active factor X variant, comprising a full-length factor X polypeptide sequence with a modified factor X activation peptide, wherein the modified activation peptide has a formula of —R 1 —P—R 2 —wherein P is a polypeptide sequence cleavable by a serine protease, R 1 is a chemical bond or one or more amino acids, and R 2 is a chemical bond or one or more amino acids, wherein the modified activation peptide of —R 1 —P—R 2 —consists of a polypeptide sequence having a total length of 3-9 amino acids and the P is not present within an activation peptide of a wild type factor X (amino acid positions Ser183 through Arg234 of SEQ ID NO:2) and replaces the activation peptide of the wild type Factor X, wherein cleavage at the P by the serine protease activates the factor X variant, wherein the serine protease is factor IIa, factor IXa, factor Xa, factor XIa, factor XIIa, activated protein C, elastase, or kallikrein, and is not furin4 and wherein the factor X variant has factor X coagulant activity.