Patent ID: 9314441
Filing Date: 2016-04-19
CPC Classification: A61K,A61P

Claim Text:
1. A pharmaceutical composition for oral administration comprising: a semi-solid hydrogel having a water content of at least 20% by weight, based on the total weight of the hydrogel, said hydrogel is a viscoelastic gel having an elastic modulus which is measured at 20° C. of 0.05 kPa to 500 kPa and which is prepared by heating an aqueous suspension of a hydratable polymeric material to induce formation of a liquid sol, followed by cooling the sol to induce gelling, a plurality of coated active ingredient containing particles dispersed in said hydrogel, wherein less than 0.1 wt % of the active ingredient is detectable in the hydrogel one month after the preparation of the composition, at least one coating of said particles is triggered to disintegrate or dissolve by exposure to a particular pH range as a result of which the active ingredient is released, the hydrogel having a pH sufficiently different from the pH that triggers disintegration or dissolution of the at least one coating of the particles so as to prevent the release of the active ingredient from the particles into the hydrogel, wherein the hydrogel comprises a buffer system, and the at least one coating consists of: a) an ionic polymer; or b) non-ionic material selected from the group consisting of lipids, waxes, fats, fatty acids, mono-, di- and triglycerides, acetylated mono- and diglycerides, beeswax, and carnauba wax; and optionally c) at least one selected from the group consisting of pH modifiers, rheological modifiers, solvents, cross-linking agents, glidants, anti-tackifying agents, pigments, dyes, emulsifiers, stabilizers, flavours, sweeteners, and permeability enhancers.