Patent ID: 9278065
Filing Date: 2016-03-08
CPC Classification: A61K,A61P

Claim Text:
1. A composition for delivering an active pharmaceutical ingredient comprising: i) a water insoluble active pharmaceutical ingredient comprising one or any combination of tacrolimus, sirolimus, ketoconazole, itraconazole, tioconazole and a cyclic N-methyl undecapeptide; ii) a water miscible solvent(s) comprising ethanol, propylene glycol, or a combination thereof; iii) an amphiphilic co-solvent(s) comprising diethylene glycol monoethylether, 1,3-dimethylisosorbide or a combination thereof; iv) at least one hydrophilic and one hydrophobic non-ionic surfactant comprising one polyethoxylated castor oil or a combination of polyethoxylated castor oils having a hydrophilic-lipophilic balance value higher than 12 and lower than 16 as the hydrophilic surfactant(s); and PEG-6 oleate as the hydrophobic surfactant; wherein the composition is free of triglycerides.