Patent ID: 9266939
Filing Date: 2016-02-23
CPC Classification: A61K,A61P,C07K

Claim Text:
1. An isolated polypeptide comprising the structure X-Fc-Y-NP-Z or the structure X-NP-Y-Fc-Z, wherein NP is a natriuretic peptide that is an agonist of natriuretic peptide receptor B (NPR-B), wherein said NP comprises the structure: [N-terminal extension]-[short segment]-[ring domain]-[C-terminal extension], wherein each of said N-terminal extension, short segment, and C-terminal extension is, independently, absent or is an amino acid sequence of at least one amino acid, and wherein said NP comprises amino acids 6-22 of SEQ ID NO: 126, wherein the amino-acid at position 17 is not Met, and wherein: (i) each of X and Z is, independently, absent or is an amino acid sequence of at least one amino acid; and (ii) the amino acid sequence of Y comprises [(Gly)