Patent ID: 9476027
Filing Date: 2016-10-25
CPC Classification: A01K,A61K,A61P,C07H,C07K,C09K,C12N

Claim Text:
1. A transgenic rabbit whose genome comprises: (a) a transgene construct encoding a full-length, human Igα subunit of SEQ ID NO: 1, under the control of a B-cell specific promoter/enhancer of CD79a; (b) a transgene construct encoding a full-length, human Igβ subunit of SEQ ID NO: 7, under the control of a B-cell specific promoter/enhancer of CD79b; and (c) a transgene construct encoding an unrearranged human immunoglobulin heavy chain locus; wherein the resultant transgene products, as a result of the simultaneous expression of the transgene constructs (a)-(c), combine to form a human B-cell receptor complex, such that human CD79a, human CD79b and human IgM are simultaneously present on the surface of B cells of said transgenic rabbit.