Patent ID: 9358302
Filing Date: 2016-06-07
CPC Classification: A61K,A61P,C07K

Claim Text:
1. A method of preparing a glycated peptide conjugate, the method comprising: obtaining a population of polysaccharides; treating the population of polysaccharides to create a treated population of polysaccharides having an average molecular weight of 10-20 kDa; contacting the treated population of polysaccharides with polypeptides comprising a plurality of repeating peptide units linked together by cleavable moieties, wherein each peptide unit consists of: (i) an MHC-II binding sequence of 20 amino acids or fewer, wherein none of the amino acids are lysine; (ii) one lysine residue at the C terminal end; and (iii) one or more amino acids linking the MHC-II binding sequence to the lysine residue, wherein none of the amino acids are lysine; under conditions sufficient to link the treated polysaccharides directly to the lysine residues, thereby preparing the glycated peptide conjugate.