Patent ID: 9347945
Filing Date: 2016-05-24
CPC Classification: C07K,G01N

Claim Text:
1. A method of aiding in a diagnosis of a subject suspected of lung cancer, the method comprising the steps of: (a) quantifying in a test sample obtained from a subject the amount of biomarkers: anti-p53, anti-NY-ESO-1, proGRP, CEA, cytokeratin 19, CA125, and human amyloid protein A; (b) comparing the amount of each quantified biomarker to a number of predetermined cutoffs for said biomarker and assigning one of a number of predetermined weighted scores for each biomarker based on said comparison, wherein the assigned weighted score for each biomarker is calculated based on a specificity of the predetermined cutoff nearest to and less than the quantified amount of said biomarker, wherein the specificities of the number of predetermined cutoffs are 0.9, 0.75 and 0.5, and wherein the weighted score is zero if the amount of the biomarker is less than the lowest predetermined cutoff for the biomarker; (c) combining the assigned weighted score for each biomarker quantified in step a to obtain a total score for said subject; (d) comparing the total score determined in step c with a predetermined total score; and (e) determining whether said subject has lung cancer based on the comparison of the total score in step d; wherein the Distance from Ideal (DFI) of the biomarkers relative to lung cancer is less than about 0.4.