Patent ID: 9232776
Filing Date: 2016-01-12
CPC Classification: A01K,C07K

Claim Text:
1. A genetically modified non-human animal comprising in its germline a replacement of non-human animal IL-7 exons with a nucleic acid comprising at least human IL-7 exons 2, 3, 4, 5 and 6 to form a humanized IL-7 gene, wherein the replacement is at an endogenous non-human animal IL-7 locus and the resulting modified non-human animal IL-7 locus lacks non-human animal IL-7 exons 2, 3, 4 and 5, wherein the humanized IL-7 gene is under control of endogenous non-human animal IL-7 5′ regulatory elements, and the IL-7 protein encoded by the humanized IL-7 gene is expressed in the serum of the non-human animal, and wherein the non-human animal is a rodent selected from a rat and a mouse.