Patent ID: 9475883
Filing Date: 2016-10-25
CPC Classification: A61K,A61P,C07K

Claim Text:
1. A method of treating a human patient with a B-cell malignancy comprising: a) exposing B cells from the human patient to a chimeric, humanized or human anti-CD22 antibody in vitro in the presence of PBMCs (peripheral blood mononuclear cells) or FcγR-positive cells; b) measuring the depletion of one or more antigens selected from the group consisting of CD19, CD20, CD21, CD22 and CD79b on the surface of the B cells, wherein the antigens are depleted by trogocytosis, to determine the sensitivity of the B cells to the anti-CD22 antibody; and c) administering the anti-CD22 antibody to the human patient, wherein the antibody is capable of inducing trogocytosis of the one or more antigens from the patient's B cells.