Patent ID: 9321839
Filing Date: 2016-04-26
CPC Classification: A61P,C07K

Claim Text:
1. A recombinant expression system which comprises one or more nucleotide sequences that encode a monoclonal antibody or fragment thereof which binds to HER3 not complexed to heregulin, and binds to HER3:heregulin complex with greater affinity as compared to binding uncomplexed HER3, said one or more nucleotide sequences operably linked to control sequences for expression; wherein the encoded monoclonal antibody or fragment comprises a heavy chain that comprises CDR1:GYTFTDYVIS (SEQ ID NO:4), CDR2:IYPGSGRY (SEQ ID NO:5) and CDR3:TRSLQRLRYFDV (SEQ ID NO:6); and comprises a light chain that comprises CDR1:RASQSISDYLH (SEQ ID NO:10), CDR2:YGSQSIS (SEQ ID NO:11) and CDR3:QQSNSWPLT (SEQ ID NO:12).