Patent ID: 9492495
Filing Date: 2016-11-15
CPC Classification: A61K,A61P,C07K

Claim Text:
1. A method for modulating collateral blood vessel growth of collateral arteries and/or non-collateral blood vessels of pre-existing arterial networks comprising administering, to a patient at risk of cardiovascular ischemic disease a bradykinin receptor 1 (B1R) agonist in an amount effective to modulate collateral blood vessel growth of (a) collateral arteries and/or (b) non-collateral blood vessels of pre-existing arterial networks, wherein said patient: (a) shows symptoms of being at risk of developing said cardiovascular ischemic disease, wherein said symptoms are: a blood pressure and/or a cholesterol level that affords an at least 10% higher risk of developing said cardiovascular ischemic disease than an average risk of developing said cardiovascular ischemic disease throughout a population, smoking, atherosclerosis, thrombosis, embolism, and/or restenosis; (b) shows a risk marker for cardiovascular ischemic disease in ex vivo tests; and/or (c) has a genetic predisposition of developing a cardiovascular ischemic disease.