Patent ID: 9289464
Filing Date: 2016-03-22
CPC Classification: A61K,G01N

Claim Text:
1. A method for diagnosing NIS gene-expressing carcinomas, metastases of carcinomas or both by stimulating or enhancing NIS gene expression in cells of the carcinomas or the metastases thereby increasing NIS-symporter function, comprising: administering to a patient in need thereof at least one PPAR-γ ligand that is a thiazolidinedione, at least one ligand selected from the group consisting of RAR ligand and RXR ligand, and a radioactive affinity containing substance actively transported by the NIS symporter into cells of the carcinomas or the metastases; and stimulating or enhancing uptake of the radioactive affinity containing substance actively transported by the NIS symporter by induction of NIS gene expression in the cells.