Patent ID: 9250244
Filing Date: 2016-02-02
CPC Classification: C07K,C12Q,G01N

Claim Text:
1. A method comprising: a) obtaining antibody heavy chain sequences and antibody light chain sequences from a population of B cells of an animal, wherein said population of B cells comprises B cells that produce antibodies that specifically bind to a target antigen; b) grouping the antibodies based on their lineage to provide a plurality of groups of antibodies, wherein the antibodies in each group have heavy chain CDR3 regions that have up to 5 amino acid substitutions relative to one another and light chain CDR3 regions that have up to 5 amino acid substitutions relative to one another; c) testing a single antibody from each group of a plurality of the groups of b) in a first assay to identify a first antibody that has an activity; and, after said first antibody has been identified: d) testing a further antibody that is in the same group as the first antibody in a second assay, thereby identifying a second antibody that has said activity.