Patent ID: 9452210
Filing Date: 2016-09-27
CPC Classification: A61K,A61P,C07K,C12N

Claim Text:
1. A method of producing influenza virus like particles (VLPs) in a plant, the VLPs comprising protein, wherein the protein consists of influenza hemagglutinin (HA), comprising: a) introducing a nucleic acid comprising a nucleotide sequence encoding the hemagglutinin (HA) operatively linked to a regulatory region active in the plant into the plant, or portion thereof, b) incubating the plant under conditions that permit the expression of the nucleic acid, thereby producing the VLPs comprising protein, wherein the protein consists of influenza hemagglutinin (HA), c) harvesting the plant, and d) purifying the VLPs, wherein the VLPs range in size from 80-300 nm.