Patent ID: 9399059
Filing Date: 2016-07-26
CPC Classification: A61K,A61P,C07K,C12N

Claim Text:
1. A non-infectious, replication incompetent, recombinant virus-like particle (VLP) comprising, in operable combination: a) Newcastle disease virus (NDV) matrix (M) protein, b) NDV nucleocapsid (NP) protein, c) a first chimeric protein comprising NDV haemagglutinin-neuraminidase (HN) protein transmembrane domain (TM) protein flanked by Newcastle Disease Virus (NDV) HN protein cytoplasmic domain (CT) protein and by a first protein sequence that comprises a first copy of a heterologous protein of interest, and d) a second chimeric protein comprising NDV fusion (F) protein transmembrane domain (TM) protein flanked by NDV F protein cytoplasmic domain (CT) protein and by a second protein sequence that comprises a second copy of said heterologous protein of interest, wherein said VLP lacks NDV RNA.