Patent ID: 9475856
Filing Date: 2016-10-25
CPC Classification: A61K,A61P,C07K,G01N

Claim Text:
1. An isolated chimeric protein comprising: an N-terminus coupled to a C-terminus, wherein the N-terminus comprises an N-terminal portion of fibroblast growth factor (FGF) 21, and the C-terminus comprises a C-terminal portion of FGF19, wherein the N-terminal portion of FGF21 comprises an amino acid sequence beginning at residue 29 and ending at any one of residues 167-197 of SEQ ID NO:152, wherein the C-terminal portion of FGF21 beginning at any one of residues 167-197 and ending at residue 209 of SEQ ID NO: 152 is progressively replaced with a C-terminal portion of FGF19 beginning at any one of residues 169-204 and ending at residue 216 of SEQ ID NO:1.