Patent ID: 9228014
Filing Date: 2016-01-05
CPC Classification: A61K,A61P,C07K

Claim Text:
1. An isolated antibody, or antigen-binding fragment thereof, that specifically binds human CD48 (SEQ ID NO:384) and blocks the interaction between human CD48 and a CD48 receptor with an IC 50 of less than about 400 pM in a CD48/CD48 receptor binding assay and comprises the complementarity determining regions (CDRs) of a heavy chain variable region (HCVR) having the amino acid sequence of SEQ ID NO:368 and the CDRs of a light chain variable region (LCVR) having the amino acid sequence of SEQ ID NO:370, wherein the CD48 receptor is human CD2 (SEQ ID NO:392) or human 2B4 (SEQ ID NO:390), and wherein the antibody or antigen-binding fragment binds an epitope within Ig domain 1 of human CD48 (amino acids 29 to 127 of SEQ ID NO:384).