Patent ID: 9527900
Filing Date: 2016-12-27
CPC Classification: A61K,A61P,C07K

Claim Text:
1. A derivative of a GLP-1 analogue, which analogue comprises a first K residue at a position corresponding to position 27 of GLP-1(7-37) (SEQ ID NO: 1); a second K residue at a position corresponding to position 37 of GLP-1(7-37), and a maximum of ten amino acid changes as compared to GLP-1(7-37); wherein the first K residue is designated K27, and the second K residue is designated K37; which derivative comprises two protracting moieties attached to K27 and K37, respectively, via a linker, wherein the protracting moiety is selected from the group consisting of Chem. 2 and Chem. 1: in which x is an integer in the range of 6-16, and y is an integer in the range of 3-17; and the linker comprises Chem. 5: wherein k is an integer in the range of 1-5, and n is an integer in the range of 1-5 and wherein Chem. 5 is included m times, wherein m is an integer in the range of 1-10; or a pharmaceutically acceptable salt, amide, or ester thereof.