Patent ID: 9322020
Filing Date: 2016-04-26
CPC Classification: A61P,C07H,C12N,C12Y

Claim Text:
1. A double-stranded short interfering nucleic acid (siNA) molecule that inhibits the expression of mutant isocitrate dehydrogenase 1 (IDH1), comprising formula (A) having a sense strand and an antisense strand: wherein, the upper strand is the sense strand and the lower strand is the antisense strand of the double-stranded nucleic acid molecule; wherein the antisense strand comprises at least 15 contiguous nucleotides of a nucleotide sequence selected from the group consisting of SEQ ID NO: 477, SEQ ID NO: 478, SEQ ID NO: 479, SEQ ID NO: 480, SEQ ID NO: 498, and SEQ ID NO: 502; and the sense strand comprises a nucleotide sequence having complementarity to the antisense nucleotide sequence; each N is independently either a nucleotide that is unmodified or chemically modified, or a non-nucleotide; each B is a terminal cap; (N) (N) X3 is an integer from 18 to 24; X4 is an integer from 15 to 21; and, [N1]-[N2]-[N3] are modified nucleotides or ribonucleotides.