Patent ID: 9434951
Filing Date: 2016-09-06
CPC Classification: A61K,A61P,C12N,C12Y

Claim Text:
1. A method of reducing formation of atherosclerotic plaques in a blood vessel in a mammal, the method comprising: identifying a mammal having atherosclerosis; and administering to the identified subject an oligonucleotide selected from the group consisting of an inhibitory RNA, an antisense oligonucleotide, and a ribozyme that decreases Map4k4 mRNA expression in an endothelial cell, in an amount sufficient to decrease the expression of Map4k4 in an endothelial cell that lines a lumen of a blood vessel in the identified mammal, thereby reducing extravasation of leukocytes from the lumen of the blood vessel and reducing formation of atherosclerotic plaques in the blood vessel in the identified mammal.