Patent ID: 9301972
Filing Date: 2016-04-05
CPC Classification: A61K,A61P,C08B

Claim Text:
1. A solution of a hyaluronic acid derivative in a pharmaceutically acceptable aqueous medium in an amount of 0.1% to 2% by weight based upon the total weight of the solution, the hyaluronic acid derivative comprising cross-linkable groups introduced into some functional groups of hyaluronic acid, the hyaluronic acid derivative having following characteristics: (1) the cross-linkable groups are a residue of cinnamic acid or a cinnamic acid derivative, and (2) a degree of substitution of the cross-linkable groups is from 10% to 25%, wherein at least one of the following is present: (A) the residue of cinnamic acid or a cinnamic acid derivative is attached to the functional groups of the hyaluronic acid by an amide bond, and wherein the functional groups are carboxy groups; and (B) the hyaluronic acid derivative has a spacer between the cross-linkable groups and the functional groups of the hyaluronic acid; and wherein the hyaluronic acid derivative is capable of being cross-linked into a cross-linked hyaluronate gel, the cross-linked hyaluronate gel comprising: a cross-linked hyaluronic acid derivative wherein some functional groups of hyaluronic acid are cross-linked to each other with a cross-linking group, the cross-linked hyaluronic acid derivative having following characteristics: (i) a cross-linking extent of functional groups of the hyaluronic acid is 1% to 7.5% based on a total number of constituent disaccharide units of the hyaluronic acid, (ii) the cross-linking group is a residue of cinnamic acid or a cinnamic acid derivative, (iii) a degree of substitution of a cross-linking group is from 10% to 25%, and (iv) a degree of cross-linking in the cross-linked hyaluronic acid derivative is from 10% to 30%, and a 1% solution of the cross-linked hyaluronate gel is capable of being extruded from a 23-gauge injection needle at 24° C. under a pressure of 5.0 Kg/cm