Patent ID: 9381247
Filing Date: 2016-07-05
CPC Classification: A61K,A61P

Claim Text:
1. An injectable insulin consisting of insulin monomers forming a hexamer in the presence of zinc, and a pharmaceutically acceptable excipient comprising zinc, an effective amount of a zinc chelator selected from the group consisting of ethylenediaminetetraacetic acid (EDTA), EGTA, alginic acid, alpha lipoic acid, dimercaptosuccinic acid (DMSA), CDTA (1,2-diaminocyclohexanetetraacetic acid), and trisodium citrate (TSC) to chelate the zinc to keep the insulin monomers and dimers dissociated; and an effective amount of a dissolution/stabilizing diacid or polyacid which stabilizes the dissociated insulin monomers and dimers; the improvement comprising an effective amount of one or more magnesium salts from about 0.1 to about 10 mg/nil to decrease injection site discomfort as compared to the injection site discomfort with the formulation in the absence of the one or more magnesium compounds.