Patent ID: 9304132
Filing Date: 2016-04-05
CPC Classification: C12N,C12Q,G01N

Claim Text:
1. A system comprising: a substrate having a surface; a plurality of nanowires attached to the surface; a plurality of cells of a first cell type or a second cell type penetrated by at least one nanowire of the plurality of nanowires; and a plurality of molecules to be delivered to the plurality of cells, wherein at least one of the nanowires further comprises a surface layer of a silicon-containing material, a first silane linker covalently bound thereto, and a first molecule of the plurality of molecules electrostatically bound to the first silane linker, wherein at least one cell of the plurality of cells penetrated by the at least one nanowire of the plurality of nanowires further contains at least some of the first molecule within the cytoplasm and not electrostatically bound to the first silane linker, wherein the plurality of nanowires has a diameter of less than 200 nm, a length of 2.5-5 μm, and a density of 0.5-5 nanowires/μm wherein the first cell type is different from the second cell type, and wherein a second molecule of the plurality of molecules is attached to a second silane linker, the second molecule being different from the first molecule, wherein the first molecule and the second molecule are connected to the same nanowire via the respective silane linkers.