Patent ID: 9381231
Filing Date: 2016-07-05
CPC Classification: A61K

Claim Text:
1. A method for improving cardiovascular adaptations in a subject attempting to conceive via an assisted reproductive technology (ART) and for improving cardiovascular adaptations to pregnancy in the subject during gestation, wherein improving cardiovascular adaptations is any one or combination of: cardiac output, systemic vascular resistance (SVR), mean arterial pressure, or glomerular filtration rate, wherein said method comprises administering to the subject an amount of relaxin, relaxin agonist that is effective in promoting cardiovascular adaptations of pregnancy, and monitoring thereafter improvements in cardiovascular adaptations in the subject; wherein the relaxin, relaxin agonist is administered to the subject in late luteal phase and continued through at least the first trimester, and wherein monitoring thereafter improvements in cardiovascular adaptations in the subject consists of any one or combination of: measuring cardiac output, calculating SVR, measuring mean arterial pressure, or measuring glomerular filtration rate.