Patent ID: 9492402
Filing Date: 2016-11-15
CPC Classification: A61K

Claim Text:
1. A composition for enhanced bioavailability of curcumin, demethoxycurcumin and bisdemethoxycurcumin; the composition comprising a formulation containing i) curcumin, demethoxvcurcumin and bisdemethoxvcurcumin at a weight ratio range from about 0.8:1:1 to about 1:1.1:1.2 and ii) an essential oil of turmeric comprising 45% ar-turmerone; wherein the formulation is made by the following method: a) drying a rhizome of turmeric to form a dried turmeric rhizome, b) powdering the dried turmeric rhizome to form a dried turmeric rhizome powder, c) adding ethyl acetate to the dried turmeric rhizome powder of part (b) to obtain solution and a residue, d) separating the residue from the solution, e) removing ethyl acetate solvent from the solution of part (d) to form an ethyl acetate extract, f) cooling the ethyl acetate extract to obtain crystals of curcuminoid and a liquid comprising a combination of an essential oil of turmeric and curcuminoids that did not crystallize; g) steam distilling the liquid of part (f) to obtain essential oil of turmeric and a waste residue, h) loading the waste residue onto a silica column; i) washing the loaded silica column with methanol and collecting, from the total volume of methanol added to the column, three successive fractions of eluate, wherein the three fractions are the first, second and third fractions and combining the second and third fractions obtain a combined eluate; j) concentrating the combined eluate of part (i) under heat and vacuum to obtain a concentrated, combined eluate, k) drying the concentrated, combined eluate to obtain a dried methanol extract, l) powdering the dried methanol extract to obtain a curcuminoid mixture powder, m) suspending the curcuminoid mixture powder in water to form a suspension and adding the distilled, essential oil of turmeric of part (g) to the suspension to obtain a mixture, n) homogenizing the mixture of part (m) to obtain a slurry, and o) drying the slurry of part (n) under heat and vacuum to form a uniform blend; wherein the uniform blend of part (o) is the formulation.