Patent ID: 9453001
Filing Date: 2016-09-27
CPC Classification: C07D

Claim Text:
1. A method for preparing avanafil, with the chemical name (S)-4-[(3-chloro-4-methoxybenzyl) amino]-2-[2-(hydroxymethyl)-1-pyrrolidinyl]-N-(2-pyrimidyl methyl)-5-pyrimidinecarboxamide (I), Wherein said preparation method comprises the following steps: using cytosine as raw material, the cytosine and 3-chlorine-4-methoxybenzyl halogen (III) have a substitution reaction, to produce N-(3-chloro-4-methoxybenzyl) cytosine (V) which then has an addition reaction with side chain N-(2-methylpyrimidine) methanamide (IV) after halogenation reaction to produce 6-(3-chloro-4-methoxy-benzylamino)-1,2-dihydro-pyrimidin-2-one-5-(N-2-methyl-pyrimidinyl) formamide (VII), and then the said 6-(3-chloro-4-methoxy-benzylamino)-1,2-dihydro-pyrimidin-2-one-5-(N-2-methyl-pyrimidinyl) formamide (VII) and S-hydroxymethyl pyrrolidine (II) have a condensation reaction to produce avanafil (I).