Patent ID: 9504672
Filing Date: 2016-11-29
CPC Classification: A61K,A61P,C07D

Claim Text:
1. A composition comprising at least one polymorph of MDT-637 selected from the group consisting of: P-2 hydrate crystal form having characteristic powder X-ray diffraction peaks at 2θ values of 4.83°, 8.42°, 9.61°, 11.83°, 14.60°, 16.94°, 19.25°, 20.46°, 24.09°, 24.85°, 27.76° and 28.56°; P-3 monohydrate crystal form having characteristic powder X-ray diffraction peaks at 2θ values of 8.25°, 9.55°, 11.66°, 14.30°, 18.03°, 19.70°, 20.29°, 24.55°, 25.29°, 26.31° and 27.26°; P-3 dihydrate crystal form having characteristic powder X-ray diffraction peaks at 2θ values of 7.03°, 8.16°, double peak at 9.47° and 9.75°, 11.60°, 14.24°, 17.95°, 19.64°, 20.26°, 24.52°, 26.24° and 27.25°; P-3 ethanolate crystal form having characteristic powder X-ray diffraction peaks at 2θ values of 8.25, 9.54, 9.85, 11.69, 14.32, 15.99, 18.06, 19.73, 20.33, 24.54, and 26.27; P-3 anhydrous crystal form having characteristic powder X-ray diffraction peaks at 2θ values of 8.27°, 9.54°, 11.68°, 14.29°, 18.07°, 19.79°, 20.30°, 24.54°, 25.27°, 26.36°, and 27.25°; P-2 anhydrous crystal form having characteristic powder X-ray diffraction peaks at 2θ values of 8.58°, 10.64°, 12.58°, 14.51°, 15.89°, 17.20°, 21.06°, 21.41°, 22.37°, 25.43° and 27.62°; P-4 crystal form having characteristic powder X-ray diffraction peaks at 2θ values of 4.31°, 7.99°, 9.37°, 11.02°, 13.04°, 13.43°, 14.18°, 16.13°, 16.70°, 17.08°, 17.42° and 17.92°; P-6 crystal form having characteristic powder X-ray diffraction peaks at 2θ values of double peak at 3.43° and 3.89°, 6.89°, double peak at 7.87° and 8.25°, 10.88°, 13.06°, 13.81°, 16.12°, 17.38° and 18.51°; P-7 crystal form having characteristic powder X-ray diffraction peaks at 2θ values of 5.18°, 6.59°, 7.70°, double peak at 10.02° and 10.62°, double peak at 12.18° and 12.50°, 15.16°, double peak at 15.88° and 16.4°, double peak at 17.20° and 17.42°, and double peak at 18.07° and 18.25°; P-8 crystal form having characteristic powder X-ray diffraction peaks at 2θ values of 4.15°, 7.85°, 9.33°, 14.29°, triple peak at 15.84°, 16.68° and 17.14°, 18.53°, 20.27°, 23.90°, 24.80° and 27.39°; and combinations thereof; wherein the powder X-ray diffraction peaks are measured using CuK