Patent ID: 9394568
Filing Date: 2016-07-19
CPC Classification: A61K,C07K,C12Q

Claim Text:
1. A method of treating or reducing the risk of anaemia in a human haemodialysis patient, the method comprising administering a trap, an antibody or an antibody fragment that binds specifically to BMP6 to the human haemodialysis patient, wherein the trap, antibody or antibody fragment comprises a constant region selected from: (a) a human gamma-4 heavy chain constant region that comprises a Leu at position 189 shown in SEQ ID NO: 73 or an Arg at position 289 shown in SEQ ID NO: 73; and (b) a human gamma-1 heavy chain constant region that comprises an Asp corresponding to position 204 of SEQ ID NO: 42 or a Leu corresponding to position 206 of SEQ ID NO: 42; and wherein the human comprises (i) a TMPRSS6 nucleotide sequence comprising a SNP rs855791; rs2543519; rs2235324; or rs1421312; and (ii) a constant region gene segment encoding said selected constant region; or said patient expresses antibodies comprising said selected constant region.