Patent ID: 9416156
Filing Date: 2016-08-16
CPC Classification: A61P,C07K,C12N

Claim Text:
1. A method of fabricating a biologically active, proteoloytic-resistant, unnatural polypeptide, the method comprising: fabricating a synthetic polypeptide that has an amino acid sequence that corresponds to a sequence of a biologically active polypeptide or fragment thereof, wherein (i) in the synthetic polypeptide from about 14% to about 50% of the α-amino acid residues found in the biologically active polypeptide or fragment are replaced with analogous β-amino acid residues, wherein at least one of the β-amino acid residues is cyclically constrained via a ring encompassing its β (ii) in the synthetic polypeptide the β-amino acid residues and the α-amino acid residues are distributed in a pattern that repeats at least once, wherein the pattern of β-amino acid residues and α-amino acid residues is selected from the group consisting of (ααααααβ), (αααααβ), (ααααβ), (αααβ), and (ααβαβαβ).