Patent ID: 9441261
Filing Date: 2016-09-13
CPC Classification: A61K,C09B,C12Q,G01N

Claim Text:
1. An assay method for determining drug susceptibility of a tuberculosis-causing Mycobacterium in a subject infected by said Mycobacterium , comprising: a) obtaining a biological sample from the subject; b) contacting said biological sample with a drug effective against the the tuberculosis-causing c) contacting said biological sample with a fluorogenic substrate CNIR800, CNIR800.2, CNIR800-3, XHX2-81, XHX2-91, XHX3-1, XHX3-26, or XHX3-32 for a beta-lactamase of the tuberculosis-causing d) delivering an excitation wavelength to the biological sample; and e) measuring a fluorescent signal intensity at an emission wavelength produced by the product of the beta-lactamase action on the substrate in the biological sample at intervals over a period of time; wherein no increase or a decrease in signal intensity over the time period correlates to susceptibility of the tuberculosis-causing