Patent ID: 9382330
Filing Date: 2016-07-05
CPC Classification: A61K,A61P,C07K,G01N

Claim Text:
1. A method for inhibiting growth, proliferation and/or inducing death of protein disulfide isomerase a4 (Pdia4)-overexpressed cancer cells, comprising (a) detecting the presence of the Pdia4-oveprxpressed cancer cells in a subject with cancer; and (b) administering to the subject with the detected presence of the Pdia4-overexpressed cancer cells a Pdia4 inhibitor in a therapeutically effective amount for inhibiting the growth, proliferation and/or inducing the death of the Pdia4-overexpressed cancer cells in the subject with the cancer, wherein the Pdia4 inhibitor is selected from the group consisting of cytopiloyne, cytopiloyne aglycone, biotinylated cytopiloyne, an Pdia4 anti-sense small interfering RNA (siRNA), and an anti-Pdia4 short hairpin RNA (shRNA).