Patent ID: 9409874
Filing Date: 2016-08-09
CPC Classification: A61P,C07B,C07D

Claim Text:
1. A method for producing a compound of the following formula [c]: wherein Ms is a methanesulfonyl group, which comprises the following steps of: (step a) reacting a compound of the following formula [a]: with methanesulfonyl halide in the presence of a base to produce a compound of the following formula [b]: wherein the symbol is the same as defined above, and (step b) reacting said compound [b] with a boronic acid compound of the following formula [d]: wherein R and R′ are the same or different and each of them is a hydrogen atom or an alkyl group, or both of them combine together to form an alkylene group, or an equivalent thereof, in the presence of a copper catalyst, in the presence or absence of a base, and in the presence or absence of a ligand selected from the group consisting of a pyridine, an imidazole, 1,4-diazabicyclo[2.2.2]octane, pyrazine, and mixtures thereof.