Patent ID: 9481735
Filing Date: 2016-11-01
CPC Classification: A61K,A61P,C07K,Y02A

Claim Text:
1. An isolated nucleic acid encoding a binding protein amino acid sequence, wherein the binding protein comprises a polypeptide chain, wherein the polypeptide chain comprises VD1-(X1)n-VD2-C-(X2)n, wherein; VD1 is a first heavy chain variable domain; VD2 is a second heavy chain variable domain; C is a heavy chain constant domain; X1 is a linker with the proviso that it is not CH1; X2 is an Fc region; and n is 0 or 1; wherein the binding protein is capable of binding human IL-17 and TNF-α; and wherein, in the polypeptide chain, said VD1 or VD2 heavy chain variable domain comprises an amino acid sequence selected from the group consisting of SEQ ID NOs: 565, 670, 720, 740, 845, and 875.