Patent ID: 9428444
Filing Date: 2016-08-30
CPC Classification: C07C

Claim Text:
1. A process for the preparation of Levothyroxine Sodium comprising the steps of: a. Coupling reaction between 3, 5-diiodo L-Tyrosine copper complex and novel Bis (p-anisyl) iodonium iodide in the presence of Diisopropylamine or other organic bases in n-Butanol or other alcoholic solvents to obtain 2-Amino-3-(3,5-diiodo-4-(4-methoxy phenoxy)phenyl)propanoic acid; b. Demethylation of 2-Amino-3-(3,5-diiodo-4-(4-methoxyphenoxy)phenyl)propanoic acid using a mixture of Acetic acid and Hydroiodic acid to obtain 3,5-diiodothyronine; c. Iodinizing 3,5-diiodothyronine with methanolic or alcoholic monomethylamine and Iodine to obtain Levothyroxine; d. Converting Levothyroxine to Levothyroxine Sodium in the presence of sodium hydroxide and n-butanol or other alcoholic solvents.