Patent ID: 9452107
Filing Date: 2016-09-27
CPC Classification: A61J,A61K,B05D,B82Y

Claim Text:
1. A method for fabricating a formulation comprising: providing active agent particles in an aqueous suspension; introducing the aqueous suspension of active agent particles to a wet media mill having a milling chamber; pumping the aqueous suspension of active agent particles through the wet media mill; operating the wet media mill at a pre-determined rpm setting; periodically and gradually introducing superdisintegrant (SDI) particles to the aqueous suspension of active agent particles in the operating wet media mill to form an aqueous suspension of SDI particles and active agent particles in the operating wet media mill; co-wet-milling the aqueous suspension of SDI particles and the active agent particles in the operating wet media mill to form a co-wet-milled suspension of co-wet-milled SDI particles and active agent particles, the co-wet-milled suspension including colloidal and ultrafine SDI particles and colloidal particles and nanoparticles of active agents; drying the co-wet-milled suspension of SDI particles and active agent particles to form a composite of SDI particles and active agent particles; wherein the co-wet-milled SDI particles have a particle size of less than about 5 microns; wherein the SDI particles and active agent particles are co-wet-milled in the wet media mill with milling media.