Patent ID: 9458460
Filing Date: 2016-10-04
CPC Classification: A61K,A61P,C12N,C12Q

Claim Text:
1. A pharmaceutical composition comprising an anti-cancer drug and an inhibitor of bone morphogenetic protein 4 (BMP4) gene expression and/or an inhibitor of bone morphogenetic protein 4 (BMP4), wherein the anti-cancer drug excludes oxaliplatin and derivatives thereof, wherein the inhibitor of BMP4 gene expression is an interfering ribonucleic acid, wherein the interfering ribonucleic acid is a shRNA comprising the sequence selected from the group consisting of 5′-TGAGGTGACTCACCTCCATCAGACTCGGA-3′ (SEQ ID NO: 23) and 5′-GCCACTCGCTCTATGTGGACTTCAGCGAT-3′ (SEQ ID NO: 24), or functional variants thereof.