Patent ID: 9439851
Filing Date: 2016-09-13
CPC Classification: A61F,A61K,A61P

Claim Text:
1. A gastric retention system which is a coated tablet comprising: (a) a core which is a tablet comprising an agent capable of generating internal pressure on the coat, wherein the agent capable of generating internal pressure is selected from the group consisting of gas generating agents and superdisintegrants, wherein the gas generating agent is selected from the group consisting of carbonates, bicarbonates, sulfites, ammonium cations, sodium azide and mixtures thereof and wherein the superdisintegrants are selected from the group consisting of crosslinked sodium carboxymethyl cellulose, crosslinked polyvinylpyrrolidone, sodium starch glycolate, ion exchange resins and mixtures thereof, and (b) an expandable coating formed by applying a coating composition comprising a film-forming polymer present in the range of 20 to 70% by weight of the expandable coating and one or more expandable components present in the range of 10 to 35% by weight of the expandable coating on the tablet core to form a film capable of expanding and maintaining its physical integrity in the gastric milieu, wherein the expandable component is selected from the group consisting of gas generating agents highly swellable polymers, superdisintegrants and mixtures thereof, wherein the gas generating agent is selected from the group consisting of carbonates, bicarbonates, sulfites, ammonium cations, sodium azide and mixtures thereof and wherein the superdisintegrants are selected from the group consisting of crosslinked sodium carboxymethyl cellulose, crosslinked polyvinylpyrrolidone, sodium starch glycolate, ion exchange resins and mixtures thereof and the highly swellable polymers are selected from alginates, carrageenan, hydroxypropyl guar, cross-linked polymer of acrylic acid or mixture thereof, and wherein said coated tablet is gastric retentive.