Patent ID: 9402875
Filing Date: 2016-08-02
CPC Classification: A61K,A61P

Claim Text:
1. A method for treating a condition associated with a deficiency in mitochondrial complex I enzyme activity in a subject comprising administering to a subject in need thereof a pharmaceutically effective amount of a composition comprising (a) a purified Amidated Dopamine Neuron Stimulating peptide (ADNS peptide) comprising the amino acid sequence ERNRQAAAANPENSRGK-amide (SEQ ID NO: 2); (b) a purified ADNS peptide comprising the amino acid sequence FPLPA-amide (SEQ ID NO: 3); or (c) a purified ADNS peptide comprising the amino acid sequence PPEAPAEDRSL-amide (SEQ ID NO: 4), or mixtures thereof, and at least one of a pharmaceutically acceptable vehicle, excipient, and diluent, wherein the composition is administered nasally, wherein the subject in need thereof has a traumatic brain injury, and wherein the composition is administered in an amount that restores mitochondrial activity as evidenced by an increase in levels of at least one of dopamine and a dopamine metabolite in the subject.