Patent ID: 9255273
Filing Date: 2016-02-09
CPC Classification: A61K,A61P,C07C,C07D,C12N,C12P,Y02A

Claim Text:
1. A method of modulating the expression of a target gene in a host cell, wherein the host cell comprises recombinant DNA encoding: (i) a transactivation domain; (ii) a DNA-binding domain; and (iii) a and a gene expression cassette comprising: (i) a response element capable of binding to said DNA binding domain; (ii) a promoter that is activated by the transactivation domain; and (iii) said target gene; the method comprising contacting said host cell with a compound selected from the group consisting of: 3,5-Dimethyl-benzoic acid N′-(2-ethyl-3-methoxy-benzoyl)-N-(2-hydroxyimino-1,1-dimethyl-ethyl)-hydrazide; Acetic acid 2-[N-(3,5-dimethyl-benzoyl)-N′-(2-ethyl-3-methoxy-benzoyl)-hydrazino]-2-methyl-propyl ester; 2-Ethyl-3-methoxy-benzoic acid N′-tert-butyl-N′-(1-methyl-1H-indole-2-carbonyl)-hydrazide; 3-(H 3-(H 2-Methoxy-6-trifluoromethyl-nicotinic acid N-tert-butyl-N′-(3-methoxy-2-methyl-benzoyl)-hydrazide; 3-Methoxy-2-methy-benzoic acid N′-tert-butyl-N′-(1-methyl-2-oxo-6-trifluoromethyl-1,2-dihydro-pyridine-3-carbonyl)-hydrazide; 1H-Benzoimidazole-5-carboxylic acid, N-tert-butyl-N′-(2-ethyl-3-methoxy-benzoyl)-hydrazide; 1-Trityl-1H-benzoimidazole-5-carboxylic acid N-tert-butyl-N′-(2-ethyl-3-methoxy-benzoyl)-hydrazide; 3-Trityl-1H-benzoimidazole-5-carboxylic acid N-tert-butyl-N′-(2-ethyl-3-methoxy-benzoyl)-hydrazide; 1H-Indazole-3-carboxylic acid N-tert-butyl-N′-(2-ethyl-3-methoxy-benzoyl)-hydrazide; 1-Trityl-1H-indazole-3-carboxylic acid N-tert-butyl-N′-(2-ethyl-3-methoxy-benzoyl)-hydrazide; 3,5-Dimethyl-benzoic acid N-[2-(tert-butyl-dimethyl-silanyloxy)-1,1-dimethyl-ethyl]-N′-(2-ethyl-3-methoxy-benzoyl)-hydrazide; 3,5-Dimethyl-benzoic acid N′-(2-ethyl-3-methoxy-benzoyl)-N-[2-(2-hydroxy-ethylimino)-1,1-dimethyl-ethyl]-hydrazide; 3,5-Dimethyl-benzoic acid N-[(H 3,5-Dimethyl-benzoic acid N-[(H