Patent ID: 9394366
Filing Date: 2016-07-19
CPC Classification: A61K,A61P,C07K

Claim Text:
1. A method of inhibiting BCR activation of at least one B cell comprising contacting the B cell with an anti-CD19 antibody comprising: an Fc region that binds FcγRIIb on the cell surface with enhanced affinity as compared to a parent antibody comprising the amino acid sequence of SEQ ID NO:4; a light chain comprising an amino acid sequence of SEQ ID NO: 7; a heavy chain comprising an amino acid sequence of SEQ ID NO: 2; and at least one amino acid substitution in the Fc region selected from: L235Y, L235R, G236D, S267D, S267E, and L328F as compared to SEQ ID NO: 4, wherein the numbering is according to the EU index, as in Kabat.