Patent ID: 9439448
Filing Date: 2016-09-13
CPC Classification: A23L,A23V,A61P

Claim Text:
1. A method for promoting oral tolerance to food protein antigens in an infant, comprising administering to the infant a nutritional composition comprising a. a lipid or fat; b. a protein source; c. about 5 to about 100 mg/100 kcal of a source of long chain polyunsaturated fatty acids which comprises docosahexanoic acid; d. about 1.0 to about 10.0 g/L of a prebiotic composition, wherein the prebiotic composition comprises at least 20% of an oligosaccharide which has a fermentation rate which is demonstrably slower than that of galacto-oligosaccharide; and e. about 2500 pg to about 10,000 pg TGF-B per mL of composition, wherein the ratio of TGF-β1: TGF-β2 is about 1:1 to about 1:20, and wherein the combination of TGF-β and the prebiotic contributes to the induction of oral tolerance to antigens in an infant, wherein the infant had established oral tolerance to the antigens but oral tolerance has since failed.