Patent ID: 9404109
Filing Date: 2016-08-02
CPC Classification: A61K,A61P,C12N

Claim Text:
1. A method for treatment of a cancer characterized by elevated expression of hsp27 as compared to non-cancerous tissue of the same type in an individual suffering from the cancer, comprising the step of administering to the individual a therapeutic composition effective to reduce the amount of active hsp27 in the cancer cells, wherein said therapeutic composition comprises an antisense oligonucleotide, said antisense oligonucleotide having a length of 12 to 35 bases; said antisense oligonucleotide comprises at least 10 bases that are complementary to a subsequence of at least 10 contiguous bases within SEQ ID No: 91, and said subsequence of contiguous bases comprises at least 10 contiguous bases selected from the group consisting of (a) bases 551-580 of SEQ ID NO: 91; (b) bases 661-681 of SEQ ID NO: 91; (c) bases 744-764 of SEQ ID NO: 91; (d) bases 131-161 of SEQ ID NO: 91; (e) bases 241-261 of SEQ ID NO: 91; and (f) bases 361-371 of SEQ ID NO: 91.