Patent ID: 9346875
Filing Date: 2016-05-24
CPC Classification: A61K,C07K

Claim Text:
1. An isolated humanized anti-filovirus glycoprotein pre-fusion core antibody comprising a framework region having a sequence of 95% or greater identity to a human antibody framework region, and comprising (a) a heavy chain CDR1 comprising GFAFNYYDM/I/LH (SEQ ID NO:1); a heavy chain CDR2 comprising YINPGGGNTYYADSV (SEQ ID NO:2); and a heavy chain CDR3 comprising QLYGNSFMDY (SEQ ID NO:3), and (b) a light chain sequence, comprising a light chain CDR1, CDR2 and CDR3, wherein the light chain comprises DIQMTQSPSSLSASVGDRVTITCK/R/QASQDVTTAVAWYQQKPGKAPKL (SEQ ID NO:12) and LIYAASRLHNGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQ (SEQ ID NO:14) and wherein the CDR3 comprises HYSTPLT (SEQ ID NO:5).