Patent ID: 9492473
Filing Date: 2016-11-15
CPC Classification: A61K

Claim Text:
1. A method of treating a human subject having diarrhea comprising administering to the subject a pharmaceutical composition comprising a glycan therapeutic preparation in an amount effective to treat the diarrhea, wherein i) the glycan therapeutic preparation comprises branched glycans that comprise glucose, galactose, arabinose, mannose, fructose, xylose, fucose, or rhamnose glycan units, ii) the average degree of branching (DB) of the branched glycans in the glycan therapeutic preparation is between 0.01 and 0.3, iii) at least 50% of the glycans in the glycan therapeutic preparation have a degree of polymerization (DP) of at least 3 and less than 30 glycan units, iv) the average DP of the glycan therapeutic preparation is between about DP6 and about DP10, v) the ratio of alpha- to beta-glycosidic bonds present in the glycans of the glycan therapeutic preparation is between about 1:1 to about 5:1, and vi) the glycan therapeutic preparation has a final solubility limit in water of at least about 60 Brix at 23° C.