Patent ID: 9458506
Filing Date: 2016-10-04
CPC Classification: C12Q

Claim Text:
1. A method for predicting blastocyst quality of a human embryo in vitro, the method comprising: analyzing expression of one or more genes associated with epigenetic regulation of gene expression wherein the genes associated with epigenetic regulation of gene expression are selected from ATF2, KAT5, MSK2, PRMT5, SETDB1, DNMT1 and AURKB; comparing the expression to a control sample; wherein altered expression levels are indicative of an greater potential for aneuploidy in the embryo, wherein an embryo or population of embryos assessed as having a low quality are cultured in medium supplemented with one or more of BDNF, IGF-I, estradiol, GDNF, leptin, FGF2, EGF, and GM-CSF.