Patent ID: 9249146
Filing Date: 2016-02-02
CPC Classification: A61K,A61P,C07D

Claim Text:
1. A method of decreasing the enzymatic activity of Bruton's tyrosine kinase comprising contacting Bruton's tyrosine kinase with an effective amount of a compound formula I: wherein: X X p is 0-5; y is 0, 1, or 2; z is 0, 1, or 2, wherein z is 0 or 1 when y is 2, and z is 1 or 2 when y is 0; each R each R is independently hydrogen or an optionally substituted group selected from C each of R each of R Ring A  and is optionally substituted, Ring A L is a covalent bond or an optionally substituted, bivalent C each Cy is independently an optionally substituted bivalent ring selected from phenylene, a 3-7 membered saturated or partially unsaturated carbocyclylene, a 3-7 membered saturated or partially unsaturated monocyclic heterocyclylene having 1-2 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or a 5-6 membered heteroarylene having 1-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur; or a pharmaceutically acceptable salt thereof.