Patent ID: 9248313
Filing Date: 2016-02-02
CPC Classification: A61N,G16H

Claim Text:
1. A method for generating a patient specific therapy plan for a patient, comprising: (a) with a processor, generating an initial therapy plan for administering an initial therapy to the patient, wherein the initial therapy plan is generated using at least one of an initial normal tissue complication probability (NTCP) model and an initial tumor control probability (TCP) model of a target region, and wherein the at least one of the NTCP model and the TCP model is adapted to the patient based on a first value of at least one biomarker of the patient; (b) administering therapy to the patient using the initial therapy plan with a therapy delivery system; (c) with the processor, generating a revised therapy plan for administering a revised therapy to the patient, wherein the revised therapy plan is generated using at least one of an updated NTCP model and an updated TCP model of the target region of the patient, wherein the at least one of the initial NTCP model and the initial TCP model is adapted to the patient based on a second value of the at least one biomarker of the patient; (d) administering therapy to the patient based on the revised therapy plan with the therapy delivery system; and wherein the at least one biomarker of the patient is Hb, CRP, PSA, TNF-α, ferritin, transferrin, LDH, IL-6, hepcidin, creatinine, glucose, HbA1c, DNA end binding complexes (DNA-EBCs), HIF-1α, Galectin-1, CAP43, NDRG1, or telomere length; wherein at least one patient biomarker is an additional biomarker chosen from in vitro test values, mass spectrometric protein signatures, tumor type, tumor grade, tumor stage, primary tumor site, Gleason score, cologenic assays, previous treatment, previous abdominal surgery, hormonal medication, anticoagulantia medication, age, diabetes, and tumor growth related measures; wherein the NTCP model includes an EUD model expressed as: where EUD is an equivalent uniform dose, D the TCP model includes an EUD model expressed as: where EUD is an equivalent uniform dose, D