Patent ID: 9399669
Filing Date: 2016-07-26
CPC Classification: A61K,A61P,C07K

Claim Text:
1. A variant ActRIIB protein comprising an amino acid sequence that is at least 95% identical to the sequence of amino acids 29-109 of SEQ ID NO:2, wherein the protein comprises at least one N-X-S/T sequence at a position other than an endogenous N-X-S/T sequence of ActRIIB, wherein the at least one N-X-S/T sequence is at a position outside of the ligand-binding pocket, wherein the protein comprises a N at the position corresponding to position 24 of SEQ ID NO: 2 and a S or T at the position corresponding to position 26 of SEQ ID NO: 2 and wherein the variant ActRIIB protein inhibits signaling by myostatin and/or GDF11 in a cell-based assay.