Patent ID: 9322833
Filing Date: 2016-04-26
CPC Classification: B82Y,C07K,G01N,Y10T

Claim Text:
1. a method of analyzing a biological sample obtained from an individual, the method comprising: isolating from the sample a very high density, ultra small, lipid-depleted particle comprising: a) apolipoprotein B (apoB); and b) a cytokeratin 8 polypeptide, wherein the isolated particle has an average particle diameter in a range of from about 7.1 nm to about 22 nm, has a density >1.21 g/mL, and has substantially no cholesterol and substantially no triglyceride; and detecting a level of the isolated particle, wherein a level of the particle that is higher than a normal control level indicates that the individual has an increased risk of cardiovascular disease (CVD) and/or that the individual has an increased risk of mortality due to a CVD.