Patent ID: 9346888
Filing Date: 2016-05-24
CPC Classification: A61P,C07K

Claim Text:
1. A method for treating a patient having a cancer associated with FN14 expression, comprising administering to the patient a composition comprising a therapeutically effective amount of an antibody, or antigen-binding fragment thereof, that binds to human FN14, wherein the antibody or fragment thereof comprises: (a) a heavy chain variable region comprising the VHCDR1 amino acid sequence set forth in SEQ ID NO:79, the VHCDR2 amino acid sequence set forth in SEQ ID NO:92 wherein Xaa at position 4 is Asp or Tyr, and the VHCDR3 amino acid sequence set forth in SEQ ID NO:93, wherein Xaa at position 2 is Ala or Gly, Xaa at position 4 is Ser or Thr, and Xaa at position 5 is Ser or Gly; and (b) a light chain variable region comprising the VLCDR1 amino acid sequence set forth in SEQ ID NO:86, the VLCDR2 amino acid sequence set forth in SEQ ID NO:39 and the VLCDR3 amino acid sequence set forth in SEQ ID NO:94, wherein Xaa at position 3 is Ala or Ile; and wherein the antibody or antigen-binding fragment thereof is at least one of (i) conjugated to a therapeutic agent, or (ii) wherein the antibody comprises an IgG Fe domain which is modified such that the antibody has enhanced ADCC activity as compared to the antibody having the unmodified IgG Fc domain; thereby treating the cancer associated with FN14 expression.