Patent ID: 9314712
Filing Date: 2016-04-19
CPC Classification: B01D,B01J

Claim Text:
1. A multimodal chromatography medium with anion exchange and cation exchange chromatographic capacity, said medium comprising: a porous solid support having an exterior surface and interior walls defining interior pores extending to openings in said exterior surface; organic ligands covalently bound to said interior walls, said ligands comprising first ion-exchange groups having a first charge, positive or negative; and micro-particles comprising second ion-exchange groups having a second charge, wherein said second charge is opposite to said first charge, said micro-particles being bound, directly or indirectly, to said exterior surface of said support, wherein said micro-particles have a first average diameter and said interior pores have a second average diameter, said first average diameter of said micro-particles being larger than said second average diameter of said interior pores, essentially preventing said micro-particles from penetrating into said interior pores, such that said medium has anion exchange and cation exchange chromatographic capacity, said medium having anion exchange, cation exchange and reverse phase chromatographic capacity wherein said ligands comprise an alkyl chain having at least 8 carbon atoms in sequence, such that said alkyl chain provides said medium with reverse phase chromatographic capacity, said interior pores having a volume average diameter of at least about 70 angstroms.