Patent ID: 9416116
Filing Date: 2016-08-16
CPC Classification: A61P,C07D

Claim Text:
1. A method of preparation of metaxalone having the following structural formula (I): comprising reaction of triglycidyl isocyanurate (TGIC) of formula (III) with m-xylenol of formula (V): characterized in that said reaction is carried out in a solvent mixture comprising a first solvent selected from the group consisting of aprotic polar solvents with dielectric constant greater than or equal to 30 and a second solvent selected from the group consisting of apolar solvents and aprotic polar solvents with dielectric constant below 30, said solvent mixture comprising from 5 to 40 wt. % of said first solvent and from 95 to 60 wt. % of said second solvent, adding the TGIC at a temperature between 30° C. and 50° C. and after adding the TGIC raising the temperature of the reaction solution to a value between 80° C. and 180° C. in a time between 120 and 180 minutes at a rate of increase not greater than 1.25° C. per minute.