Patent ID: 9498439
Filing Date: 2016-11-22
CPC Classification: A61K,A61P,Y10S

Claim Text:
1. A composition for in vivo delivery of a compound to a target cell, the composition comprising a non-liposomal particle and at least one prodrug, wherein (a) the particle has an outer surface that is a membrane comprised of the at least one prodrug, and is further comprised of about 100 mol % to about 60 mol % phospholipid, and (b) the prodrug comprises fumagillol or a derivative of fumagillol in which the spiro epoxide at C4 is ring opened to afford a tertiary alcohol and a ClCH and the phosphoglyceride is attached at the amine, and wherein the fumagillol may be released from the phosphoglyceride backbone via enzyme cleavage.