Patent ID: 9301995
Filing Date: 2016-04-05
CPC Classification: A61K,A61P,C12N,C12Y

Claim Text:
1. A method for reducing the likelihood of a beta-lactam antibiotic-induced adverse effect in a subject in need thereof, comprising administering an effective amount of a beta-lactamase to the subject, wherein: the subject is receiving a beta-lactam antibiotic, the beta-lactam antibiotic being a substrate of the beta-lactamase, the beta-lactamase comprises an amino acid sequence having at 90% sequence identity with SEQ ID NO: 1 and an asparagine (N) or arginine (R) residue at a position corresponding to position 276 according to Ambler classification, and the beta-lactamase hydrolyzes ceftriaxone substantially more efficiently than a beta-lactamase of SEQ ID NO: 1 that has an aspartic acid (D) at a position corresponding to position 276 according to Ambler classification.