Patent ID: 9399779
Filing Date: 2016-07-26
CPC Classification: C07K,C12N

Claim Text:
1. An alternative splicing construct comprising a promoter operably linked to, in 5′ to 3′ order, (i) a CD44 exon 5 or 5′ fragment thereof, wherein the 5′ fragment comprises the 5′ splice recognition site of CD44 exon 5, wherein the CD44 exon 5 consists of SEQ ID NO: 1, (ii) an intervening nucleic acid sequence containing one or more stop codons, (iii) a variable CD44 exon or 3′ fragment thereof, wherein the 3′ fragment comprises the 3′ splice recognition site of the variable CD44 exon, and (iv) a nucleic acid sequence encoding a toxin protein or an indicator protein.