Patent ID: 9228189
Filing Date: 2016-01-05
CPC Classification: C12N

Claim Text:
1. An oligonucleotide comprising a sequence complementary to an mRNA from a c-myc gene, wherein the nucleoside subunits of the oligonucleotide are joined by intersubunit linkages, wherein the oligonucleotide comprises two or more N3′→ P5′ thiophosphoramidate linkages independently located on both the 5′ and 3′ ends of the oligonucleotide, wherein the oligonucleotide further comprises two or more contiguous thiophosphate or phosphate linkages located in between the two or more N3′→ P5′ thiophosphoramidate linkages, wherein the oligonucleotide is about 6 to about 30 nucleotides in length, and wherein the oligonucleotide is a substrate for RNase-H-mediated degradation of the mRNA from a c-myc gene.