Patent ID: 9408455
Filing Date: 2016-08-09
CPC Classification: A45D,B65D

Claim Text:
1. A method comprising: (a) filling with a substance a sterile assembly including a variable-volume storage chamber, and a one-way valve coupled in fluid communication with the variable-volume storage chamber and including an elastic valve member forming a normally closed valve opening, wherein the valve member is movable between a normally closed position, and an open position with at least a segment of the valve member spaced away from the closed position to allow the passage of substance from the variable-volume storage chamber through the valve opening, and configured such that one or more of (a) the energy required to open respective segments of the valve member progressively decreases in a direction from an upstream end toward a downstream end of the valve opening or (b) a segment of the valve member is not spaced away from the closed position substantially throughout any period of dispensing to maintain a hermetic seal between the valve opening and ambient atmosphere; wherein the filling step comprises: