Patent ID: 9404113
Filing Date: 2016-08-02
CPC Classification: A61K,A61P,C12N,C12Y

Claim Text:
1. A method of treating obesity in a subject comprising administering to the subject a compound or pharmaceutically acceptable salt thereof consisting of a single-stranded modified oligonucleotide targeted to PTP1B consisting of 20 linked nucleosides having a nucleobase sequence of SEQ ID NO: 26, wherein the modified oligonucleotide comprises: A gap segment consisting of ten linked deoxynucleosides; A 5′ wing segment consisting of five linked nucleosides; And a 3′ wing segment consisting of five linked nucleosides; wherein the gap segment is positioned between the 5′ wing segment and the 3′ wing segment; each nucleoside of each wing segment comprises a 2′-O-methoxyethyl sugar; each internucleoside linkage is a phosphorothioate linkage; and each cytosine of the modified oligonucleotide is a 5-methylcytosine; and wherein the administration of the compound or pharmaceutically acceptable salt thereof thereby treating obesity in the subject.