Patent ID: 9304136
Filing Date: 2016-04-05
CPC Classification: G01N,H01J,Y10T

Claim Text:
1. A method for diagnosing a disorder associated with increased peroxisomal proliferation comprising: (a) selecting a male or female subject suspected to suffer from increased peroxisomal proliferation, wherein said male or female is suspected to have been in contact with a compound capable of inducing peroxisomal proliferation; (b) obtaining a blood sample that was taken from the male or female subject, wherein the blood sample contains one or more analytes; (c) removing the cellular constituents from the blood sample using centrifugation to create a test sample; (d) determining the amount of at least five of the following analytes Coenzyme Q10, 16-Methylheptadecanoic acid, 17-Methyloctadecanoic acid, Eicosatrienoic acid (C20:3), Threonine, Proline, Tyrosine, trans-4-Hydroxyproline from the test sample from the male subject, or the amount of at least five of the following analytes Pantothenic acid, Coenzyme Q9, Glycerol, Palmitic acid (C16:0), Linoleic acid (C18:cis[9,12]2), 14-Methylhexadecanoic acid, gamma-Linolenic acid (C18:cis[6,9,12]3), 16-Methylheptadecanoic acid, Threonic acid, Cytosine, Phosphatidylcholine (C18:0/C22:6) from the test sample from the female subject; (e) comparing the amounts determined in step (d) to corresponding reference results, wherein the reference results comprise (f) based on the comparison of step (e), diagnose the disorder by monitoring, confirmation, or classification of the disorder or its symptoms in the male or female subject.