Patent ID: 9504586
Filing Date: 2016-11-29
CPC Classification: A61F,A61K,A61L,A61M,B05D,C23C,Y10T

Claim Text:
1. A method of using a pressure-actuated substance delivery system, wherein the pressure-actuated substance delivery system includes a substrate, a substance within a pressurized cavity of the substrate, a frangible layer disposed over a surface of the substrate, including over an opening to the cavity, and a substantially non-frangible layer of an implant-environment-dissipative material disposed over the frangible layer, wherein the frangible layer has a rupture threshold within a range of approximately 200 millimeters of mercury (mmHg) to 1200 mmHg, and a rupture time of at least 15 seconds and wherein the pressurized cavity is pressurized to a pressure that exceeds the rupture threshold by a rupture pressure within a range of approximately 20 mmHg to 50 mmHg relative to one atmosphere to cause the frangible layer to rupture when implant environment pressure falls below and remains below the rupture pressure for at least 15 seconds, the method comprising: introducing the pressure-actuated substance delivery system within an implant environment such that the substantially non-frangible layer contacts an implant environment fluid, wherein the substantially non-frangible layer is dissipated within the implant environment in response to contacting the implant environment fluid, and the frangible layer is exposed to the implant environment such that the frangible layer is exposed to the implant environment pressure in response to the substantially non-frangible layer being dissipated, wherein the frangible layer ruptures within the implant environment in response to a difference in pressure between the implant environment and the cavity that exceeds a rupture threshold of the frangible layer; and wherein the substance is released from the cavity into the implant environment through the opening in response to rupturing of the frangible layer.