Patent ID: 9475752
Filing Date: 2016-10-25
CPC Classification: C07C

Claim Text:
1. A method for manufacturing 3,4,5-tricaffeoylquinic acid, the method comprising at least Step (1) of allowing a compound represented by Formula (1) or a compound represented by Formula (2) to react with a compound represented by Formula (4); and Step (2) of deprotecting the product obtained in Step (1), and producing 3,4,5-tricaffeoylquinic acid represented by Formula (6): where in Formula (1), R 1 represents a hydrogen atom or a hydroxyl protective group; R 2 represents a hydrogen atom or a carboxyl protective group; at least one of R 1 and R 2 is not a hydrogen atom or R 1 and R 2 are joined together to form a protective group represented by —B(R a )—; R a represents a C 1-6 alkyl group which may be substituted, an aryl group which may be substituted, or a C 1-6 alkoxy group which may be substituted; and R 3 , R 4 and R 5 , which are identical or different, each represent a hydrogen atom or a group represented by Formula (3), in Formula (2), Y represents * when M is a boron atom, m represents 2, and A represents a monovalent cation; when M is a silicon atom, m represents 2, and A does not exist; when M is a divalent metal ion, m represents 2, and A does not exist; and when M is a trivalent metal ion, m represents 3, and A does not exist, and at least one of R where in Formula (3), R 6 and R 7 , which are identical or different, each represent a phenolic hydroxyl protective group; or R 6 and R 7 are joined together to form a protective group selected from the group consisting of a carbonyl group (—CO—) and a methylene group which may be substituted; and * represents the position of bonding to an oxygen atom of the compound represented by Formula (1), and where in Formula (4), X 1 represents a hydroxyl group or a leaving group; and R 6 and R 7 have the same meanings as described above, wherein a compound represented by Formula (1a) is used in the Step (1), and the method comprises, before the Step (1), Step (3) of allowing a compound represented by Formula (A3) to react with a compound represented by Formula (A5), and thereby obtaining the compound represented by Formula (1a): where in Formula (1a) and Formula (A3), R1 represents a hydrogen atom or a hydroxyl protective group; and in Formula (1a) and Formula (A5), R2 represents a hydrogen atom or a carboxyl protective group, provided that at least one of R1 and R2 is not a hydrogen atom.