Patent ID: 9278952
Filing Date: 2016-03-08
CPC Classification: A61P,C07B,C07C,C07D,C30B

Claim Text:
1. A method of obtaining a purified pharmaceutically acceptable salt of a [5-(4,6-dimethyl-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl-piperidin-4-yl)-propyl]-amine, comprising: forming a hemitartrate salt of the compound of formula (2): in a low-alkyl alcohol solvent to yield a hemitartrate salt alcohol mixture; a first crystallizing out of said mixture the solid hemitartrate of formula 2.1: dissolving said solid hemitartrate in a low-alkyl alcohol-containing medium to yield a low-alkyl alcohol-containing hemitartrate solution; a second crystallizing out of said hemitartrate solution a re-crystallized hemitartrate of formula 2.1; dissolving said hemitartrate in water to yield an aqueous hemitartrate solution; seeding said aqueous solution with crystal seeds of the tetrahydrate of said hemitartrate; and a third crystallizing said aqueous hemitartrate solution to form the solid tetrahydrate hemitartrate of formula (3):