Patent ID: 9353078
Filing Date: 2016-05-31
CPC Classification: A61K,A61P,C07D

Claim Text:
1. A method for treating or ameliorating in a mammal a disease or condition that is causally related to RAGE activity in vivo, which comprises administering to the mammal an effective disease-treating or condition-treating amount of a compound according to formula B-I′: wherein each A Z is substituted amino, substituted hydroxyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; X is CR R R R each R R and each of the subscript m and n is independently 1, 2, or 3; or a pharmaceutically acceptable salt, solvate or prodrug thereof; or stereoisomers, isotopic variants and tautomers thereof; wherein the disease or condition is selected from diabetes and its complications, atherosclerosis, peripheral vascular disease and associated complications, cardiovascular disease nephropathy,retinopathy, cardio- and cerebrovascular ischemia/reperfusion injury, heart attack, myocardial infarction, ischemic cardiomyopathy, cancer, tumor invasion and metastases, acute and chronic inflammation, arthritis,allergy asthma, obesity, pollution-associated tissue or organ damage, infection, sepsis, pneumonia, liver injury/damage, amyloidoses, skin disorders, colitis, lupus, and impaired wound healing.