Patent ID: 9339487
Filing Date: 2016-05-17
CPC Classification: A61K,A61P,Y10T

Claim Text:
1. A dry powder pharmaceutical composition for inhalation comprising a mixture of (a) a medicinal component which is a mixture of (i) a compound of the following formula (I): a pharmaceutically acceptable salt thereof, or a hydrate thereof, and (ii) a compound of the following formula (II): a pharmacologically acceptable salt thereof, or a hydrate thereof, and (b) a diluting agent comprising a mixture of a first lactose hydrate and a second lactose hydrate which have different particle size distributions, wherein the medicinal component has a 50% by weight particle size of 3.2 μm or less and a 90% by weight particle size of 8.0 μm or less as measured by a particle size analysis-laser diffraction method, and having 15% to 25% by weight on an anhydrous basis of the medicinal component, wherein the first lactose hydrate has a particle size distribution satisfying the following condition: the particle size distribution of the first lactose hydrate measured by a particle size analysis-laser diffraction method has a 10% by weight particle size of 19 μm to 43 μm, a 50% by weight particle size of 53 μm to 66 μm, and a 90% by weight particle size of 75 μm to 106 μm, and the second lactose hydrate satisfying the following condition: the particle size distribution of the second lactose hydrate measured by a particle size analysis-laser diffraction method has a 10% by weight particle size of 1 μm to 3 μm, a 50% by weight particle size of 11 μm to 20 μm, and a 90% by weight particle size of 37 μm to 54 μm.