Patent ID: 9290756
Filing Date: 2016-03-22
CPC Classification: B32B,C12M,C12N,G01N,Y10T

Claim Text:
1. An electrophysiology culture plate, comprising: a substrate having an upper surface and a lower surface comprising printed circuit board (PCB), the substrate defining a plurality of open ports in the PCB, each port extending from the upper surface to the lower surface of the substrate; a plurality of light transmissive optical plates, each optical plate being coupled to the substrate in registration with a respective port to define a substantially transparent region for the respective port; a plurality of microelectrodes, wherein each microelectrode is mounted on a top surface of a respective optical plate in the substantially transparent region; a plurality of conductive traces, each conductive trace extending from a respective microelectrode mounted on the top surface of the optical plate to an electrical contact exposed on the lower surface of the substrate, wherein the electrical contact is configured to interface with external electronics, and wherein the substrate defines a plurality of vias to operatively receive the plurality of conductive traces; a plurality of culture wells, wherein each culture well defines an interior cavity and an at least partially open bottom surface, and wherein each culture well is mounted thereto the top surface of a respective optical plate, wherein at least one respective microelectrode of the plurality of microelectrodes underlies the at least partially open bottom surface of a respective culture well and is in communication with the interior cavity of the respective culture well of the plurality of culture wells.