Patent ID: 9486493
Filing Date: 2016-11-08
CPC Classification: A61K,A61P

Claim Text:
1. A method for reducing pain in a patient with a weakened blood-brain barrier, comprising peripherally administering to the patient with a weakened blood-brain barrier a peptide with the formula where R1 is an amino acid residue of D-alanine, D-serine, D-threonine, D-methionine, D-leucine, D-asparagine or D-glutamine, whereas R2 is an amino acid residue of phenylalanine or tryptophan thereby reducing pain in the patient with a weakened blood-brain barrier, wherein the peptide is peripherally administered in a sub-threshold dose, wherein the sub-threshold dose is a dose which produces no analgesic effect in a patient without a weakened blood-brain barrier, and wherein the pain is occurring during disease states accompanied by inflammation.