Patent ID: 9345739
Filing Date: 2016-05-24
CPC Classification: A61K,A61P,C07K,G01N

Claim Text:
1. A method of reducing proteinuria in a subject having proteinuria associated with podocytes exhibiting increased uPAR-induced αvβ3 integrin activation, the method comprising: detecting, using an antibody-based assay, increased podocyte αvβ3 integrin activation in a subject having proteinuria, wherein the antibody based assay comprises contacting a kidney sample comprising podocytes from the subject having proteinuria with an antibody that binds to activated αvβ3 integrin; administering to the subject an antibody that specifically binds β3 integrin and inhibits the interaction of uPAR with αvβ3 integrin on the surface of podocytes in an amount effective to reduce the proteinuria; and measuring the subject's urinary protein prior to and after the administration of the antibody, wherein a reduction in the amount of urinary protein indicates that the proteinuria is reduced.