Patent ID: 9272077
Filing Date: 2016-03-01
CPC Classification: A61F,A61L,A61P,C23C,G03F

Claim Text:
1. A method for making an implantable, biocompatible material, comprising the steps of: a. providing an implantable, biocompatible material having at least one surface intended to contact tissue and body fluids in vivo; b. providing a mask having a defined pattern of openings corresponding in size and spacing to a predetermined distribution of endothelial cell binding domains to be imparted to the at least one surface; c. treating the at least one surface of the biocompatible material through the mask by at least one of: i. vacuum depositing a layer of material onto the at least one surface, wherein the vacuum deposited layer is different from the at least one surface immediately therebeneath in a material property selected from the group of material properties consisting of: grain size, grain phase, grain material composition, surface topography, and transition temperature, and removing the mask to yield a plurality of binding domains defined on the at least one surface of the implantable, biocompatible material; and ii. vacuum depositing a layer of sacrificial material onto the at least one surface, removing the mask from the at least one surface, vacuum depositing a second layer of material onto the at least one surface, wherein the second vacuum deposited layer is different from the at least one surface immediately therebeneath in a material property selected from the group of material properties consisting of: grain size, grain phase, grain material composition, surface topography, and transition temperature, and removing the sacrificial material to yield a plurality of binding domains defined on the at least one surface of the implantable, biocompatible material.