Patent ID: 9441227
Filing Date: 2016-09-13
CPC Classification: A61P,C12N

Claim Text:
1. A nucleic acid molecule capable of reducing the expression of a target gene comprising: a first oligonucleotide strand that is 25-30 nucleotides in length and contains 1-3 DNA bases on the 3′ end of the first oligonucleotide strand; and a second oligonucleotide strand that is 25-30 nucleotides in length comprising an overhang of unmodified and/or modified nucleotides and a domain that hybridizes to the first oligonucleotide strand comprising unmodified and modified nucleotides, wherein said second oligonucleotide strand is sufficiently complementary to a target mRNA encoded by said target gene to reduce target gene expression when said nucleic acid molecule is introduced into a subject or a cell derived from said subject.