Patent ID: 9274097
Filing Date: 2016-03-01
CPC Classification: B82Y,C12Q,G01N,Y10S

Claim Text:
1. A method for controlling translocation of an electrically charged molecule through a nanopore comprising: applying a molecular translocation voltage across a nanopore between a molecular inlet entrance at the nanopore and a molecular outlet exit at the nanopore; applying to at least one electrically conducting probe disposed at the nanopore a first voltage bias with respect to the translocation voltage, while the translocation voltage is applied across the nanopore, to slow progression of a molecule through the nanopore between the molecular inlet and the molecular outlet; electrically detecting the molecule at the nanopore while the first voltage bias is applied; and applying to at least one electrically conducting probe disposed at the nanopore a second voltage bias will respect to the translocation voltage, while the translocation voltage is applied across the nanopore, to cause the molecule to proceed through the nanopore between the molecular inlet entrance and the molecular outlet exit at the nanopore.