Patent ID: 9340618
Filing Date: 2016-05-17
CPC Classification: A61P,C07K,G01N

Claim Text:
1. An isolated or recombinant IL-11Rα-binding protein comprising an antigen binding domain of an antibody, wherein the antigen binding domain specifically binds to IL-11Rα and neutralizes IL-11 signaling, and the antigen binding domain binds to an epitope comprising residues within the first fibronectin III domain of IL-11Rα, wherein the first fibronectin III domain comprises amino acids 111-215 of SEQ ID NO: 1, and wherein the antigen binding domain comprises a heavy chain variable region (V H ) and a light chain variable region (V L ), the V H comprising: (i) a complementarity determining region (CDR) 1 comprising a sequence set forth between amino acids 31-35 of SEQ ID NO: 37 optionally comprising three or fewer amino acid substitutions, a CDR2 comprising a sequence set forth between amino acids 50-66 of SEQ ID NO: 37 optionally comprising four or fewer amino acid substitutions and a CDR3 comprising a sequence set forth between amino acids 99-107 of SEQ ID NO: 37 optionally comprising four or fewer amino acid substitutions; or (ii) a sequence at least about 95% identical to the sequence set forth in SEQ ID NO: 37.