Patent ID: 9341630
Filing Date: 2016-05-17
CPC Classification: A61K,C07D,C09B,G01N

Claim Text:
1. A fluorogenic compound comprising at least two acceptor-containing moieties and a donor-containing moiety arranged such that: (i) said at least two acceptor-containing moieties and said donor-containing moiety form a conjugated π-electron system devoid of resonating electrons, such that the compound is incapable of emitting NIR infrared light; and (ii) upon a chemical event, said donor-containing moiety rearranges so as to transfer π-electrons to one of said acceptor-containing moieties and, as a result, said acceptor-containing moiety becomes a donor-containing moiety to at least one another acceptor-containing moiety, to thereby enable emission of near infrared light, the fluorogenic compound having the general Formula I: wherein: Q wherein R is hydrogen, alkyl and cycloalkyl, at least one of said Q 1 and Q 2 being an ammonium form of an indolenine or ammonium form of a pyridine; Z and Y form said donor-containing moiety, said donor-containing moiety comprising an aryl substituted by at least one electron-donating group, and is such that upon said chemical event, it rearranges by undergoing a 1,4-quinonemethidine-like rearrangement; and; L wherein said donor-containing moiety forms a part of, or is attached to, said carbomethine-containing chain and wherein each of L