Patent ID: 9511051
Filing Date: 2016-12-06
CPC Classification: A61K,A61M,A61P

Claim Text:
1. A method for producing a patch, comprising: mixing asenapine or a pharmaceutically acceptable salt thereof with sodium acetate whose particle diameter D50 at a cumulative volume of 50% in a particle diameter distribution is in a range of 40 μm to 1000 μm, such that sodium diacetate having a particle diameter D50 of 10 μm or smaller is generated from the sodium acetate, thereby obtaining a mixture comprising the sodium diacetate and the asenapine or pharmaceutically acceptable salt; obtaining an adhesive agent layer composition by mixing the mixture and a pressure-sensitive adhesive base agent, wherein acetic acid is not added; and forming an adhesive agent layer comprising the sodium diacetate, the asenapine or pharmaceutically acceptable salt thereof, and the pressure-sensitive adhesive base agent, by applying the adhesive agent layer composition to a support layer, wherein the adhesive agent layer measured by X-ray diffraction has a peak intensity from the sodium diacetate which is higher than a peak intensity from the sodium acetate.