Patent ID: 9428768
Filing Date: 2016-08-30
CPC Classification: A61K,C12N,C12Q

Claim Text:
1. A method for removing contaminants from a adenovirus-containing composition comprising obtaining an aqueous composition comprising a selected adenovirus and undesirable contaminants and subjecting the aqueous composition to size partitioning purification using a size partitioning membrane having partitioning pores that retain virus and permit the passage of contaminants there through to remove contaminants and thereby provide a purified virus composition, wherein the virus composition is subjected to at least 10-fold diafiltration, and wherein the aqueous composition is obtained by a method comprising: growing host cells in a serum-free medium; providing nutrients to said host cells; infecting said host cells with the adenovirus; and lysing said host cells to provide an aqueous composition comprising adenovirus.