Patent ID: 9523124
Filing Date: 2016-12-20
CPC Classification: B01J,B01L,C12Q

Claim Text:
1. A reaction device for nucleic acid analysis, comprising: a substrate, a sample-immobilizing layer on the substrate, a nucleic acid sample or a carrier having a nucleic acid sample on its surface, which is immobilized on the sample-immobilizing layer through phosphate group or phosphoester bond of the nucleic acid, and a blocking layer that covers an area other than an area where the nucleic acid sample or the carrier is bound to the sample-immobilizing layer, wherein the sample-immobilizing layer is formed of an inorganic oxide, the blocking layer is selected from the group consisting of a carboxylic compound, a sulfuric acid compound, a salt thereof, and a mixture of at least 2 types of these compounds, the compound used for the formation of the blocking layer has a hydrophobic site, the hydrophobic site is long chain alkyl group, a carboxylic acid group and/or sulfate group within the compound binds to the inorganic oxide, and the inorganic oxide is selected from the group consisting of titania, zirconia, alumina, zeolite, vanadium pentoxide, silica, sapphire, tungsten oxide, tantalum pentoxide, and a mixture of at least 2 types thereof.