Patent ID: 9381171
Filing Date: 2016-07-05
CPC Classification: A61K

Claim Text:
1. A method of treating a side effect of a glucocorticoid in a subject, the method comprising: selecting a subject for administration of dapsone to reduce the side effect of a glucocorticoid treatment, wherein selecting the subject comprises measuring the level of Akt activity, FOXO1 activity, Atrogin-1 activity, MuRF-1 activity, or a combination thereof in a subject or biological sample from a subject, and selecting the subject for dapsone administration if Akt activity is decreased, FOXO1 activity is increased, Atrogin-1 activity is increased, or MuRF-1 activity is increased as compared to the activity levels of the same proteins in a subject not undergoing steroid treatment; and administering dapsone, a pharmaceutically acceptable salt, a solvate, or a combination thereof to the subject treated with a glucocorticoid and exhibiting a side effect of a glucocorticoid, wherein the dapsone, a pharmaceutically acceptable salt, a solvate, or a combination thereof treats the side effect.