Patent ID: 9234011
Filing Date: 2016-01-12
CPC Classification: A61K,A61P,A61Q,C07K,C12Y,Y02A

Claim Text:
1. A transport protein, obtained by modification of the heavy chain of a Clostridium botulinum type A (BoNT/A), said heavy chain comprising a H N -fragment and a H C -fragment, wherein said H C -fragment includes a H CC -fragment and a H CN -fragment, said H CC -fragment corresponding to amino acids 1092 to 1296 of the Clostridium botulinum neurotoxin type A (SEQ ID NO.: 1, 14, 15 or 16), are substituted by one of the following sequences: corresponding to corresponding to corresponding to corresponding to corresponding to corresponding to wherein said transport protein binds to a nerve cell.