Patent ID: 9238081
Filing Date: 2016-01-19
CPC Classification: A61K,B82Y,C07K,G01N

Claim Text:
1. A method of detecting or diagnosing pancreatic cancer comprising: a) administering to an individual an antibody construct comprising at least one anti-MUC-5ac monoclonal antibody or antigen-binding fragment that binds to the same epitope as or competes for binding to pancreatic cancer mucin with a chimeric PAM4 (cPAM4) antibody that comprises the light chain variable region CDR sequences CDR1 (SASSSVSSSYLY, (SEQ ID NO:1); CDR2 (STSNLAS, SEQ ID NO:2); and CDR3 (HQWNRYPYT, SEQ ID NO:3); and the heavy chain variable region CDR sequences CDR1 (SYVLH, SEQ ID NO:4); CDR2 (YINPYNDGTQYNEKFKG, SEQ ID NO:5) and CDR3 (GFGGSYGFAY, SEQ ID NO:6); and b) detecting the antibody construct bound to pancreatic cancer cells.