Patent ID: 9345789
Filing Date: 2016-05-24
CPC Classification: A61K,C07K

Claim Text:
1. A compound, having a formula according to either Formula I or Formula II below wherein, (a) R1 is either (i) linker-label, wherein linker is lower alkyl, lower alkyl-aryl, or aryl; and label is a radiolabel or an optical label, said linker optionally comprising a cell penetrating peptide; or (ii) lower alkyl, lower alkyl-aryl, or aryl without a label; (b) P3 is a side chain of leucine or a non-natural amino-acid selected from the group consisting of (2-furyl)alanine, (2-thienyl)alanine, 4-pyridylAla, 1-amino-1-cyclohexane carboxylic acid, 1-amino-1-cyclopentane carboxylic acid, 2-Abz, 3-Abz-, 2-Abu, 3-amino-3-phenyl propionic acid, dehydroAbu, ACPC, Aib, AllylGly, Amb, Amc, Bip, Bpa, Cba, Cha, deltaLeu, deltaVal, Hyp, Igl, Inp, 1-Nal, 2-Nal, Nva, 4-nitroPhe, 4-MethylPhe, 4-Methyl-D Phe, Phe(pI), Phe-4-NH(Boc), hPhe, Phg, pip, Dpip, propargylglycine, Thz, Tic, Tle, 3-NitroTyr, Fmoc-L-neopentylglycine, Fmoc-pCl-L-Phe-OH, Fmoc-pBr-L-Phe-OH, Fmoc-4-amino-tetrahydropyran-4-carboxylic acid, Fmoc-L-Hol, Fmoc-Pip(Boc)-OH, Fmoc-L-styrylalanine, Fmoc-L-homoCha, Fmoc-L-Dab(Boc)-OH, Fmoc-L-Dapa(Boc)-OH, Fmoc-4-[2-(Boc-amino)ethoxy]-L-phenylalanine, and Fmoc-4-(tert-butoxycarbonylmethoxy)-L-phenylalanine; (c) P2 is selected from the group consisting of (i) proline such that the compound of Formula I is (ii) a side chain of leucine, and (iii) a side chain of a non-natural amino acid as defined for P3; (d) W has the formula of a C double bonded to its adjacent CH group or an epoxide group wherein W is C and an epoxide oxygen is bonded to it and an adjacent carbon; and (e) R2 is selected from the group consisting of lower alkyl, aryl, and lower alkyl-aryl.