Patent ID: 9492446
Filing Date: 2016-11-15
CPC Classification: A61K,A61P

Claim Text:
1. A method for improving the dissolution rate of an itraconazole-containing solid dispersion, said method comprising: dissolving itraconazole, polymer and lactic acid into a solvent to thereby prepare a solution; and drying the solution, thereby preparing said itraconazole-containing solid dispersion, wherein the itraconazole is present in the solid dispersion in an amorphous form, and wherein the polymer is at least one selected from the group consisting of hydroxyalkylcellulose, polyalkene oxide, polyethylene-polypropylene copolymer, polyoxyethylene-polyoxypropylene copolymer, polyvinylalcohol, polyvinylpyrrolidone, diethylaminoacetate, and aminoalkylmethacrylate copolymer, and wherein the polymer is used in the range of 0.4-3 parts by weight based on the 1 part by weight of itraconazole, wherein the lactic acid is used in the range of 0.2-5 parts by weight based on the 1 part by weight of itraconazole, wherein the solution is prepared with both water and at least one solvent selected from the group consisting of, dichloromethane, ethanol, methanol, chloroform, and acetone, wherein the water is used at a weight of between 1 and 20 (w/w) % by the weight of the total solvent, wherein the method does not use phosphoric acid.