Patent ID: 9447167
Filing Date: 2016-09-20
CPC Classification: A01K,C07K

Claim Text:
1. A transgenic silkworm whose genome comprises cDNAs of human fibrinogen subunits Aα, Bβ and γ, wherein each of said cDNAs comprises a 5′-UTR sequence and is functionally linked to a promoter of a sericin gene, and a region encoding an original signal peptide in each of said cDNAs is replaced with a region encoding human calreticulin signal peptide, and cDNA of the subunit Aα lacks a region encoding 15 amino acids at a C-terminus; and wherein said cDNAs encode said human fibrinogen subunits in middle silk glands of the transgenic silkworm, and said transgenic silkworm produces human fibrinogen in a sericin layer of the cocoon filament, said human fibrinogen having coagulation activity.