Patent ID: 9387251
Filing Date: 2016-07-12
CPC Classification: A61K,C12N

Claim Text:
1. A method for formulating nucleic acid compositions with sugars and sugar alcohols into stable complexes for both in-vitro and in-vivo delivery into mammalian cells, comprising: (a) providing at least a nucleic acid composition with at least a negative charge; (b) preparing at least one sugar or sugar alcohol composition modified by glycylation to form a glycylated sugar or sugar alcohol composition; wherein said glycylation is a chemical reaction that replaces the hydroxyl (HO—) groups of a sugar alcohol or sugar with glycyl (NH wherein the sugar alcohol has a formula of H(HCHO) (c) mixing the nucleic acid composition from (a) and the glycylated sugar or sugar alcohol composition from (b) together under a condition below pH 8.0 to form at least a delivery complex.