Patent ID: 9421255
Filing Date: 2016-08-23
CPC Classification: A61K,A61P

Claim Text:
1. An immune-stimulating composition, comprising: a) an adjuvant component comprising of at least one immunostimulatory nucleic acid sequence, complexed with a complexing agent; b) a nucleic acid sequence encoding an antigen; and c) a carrier molecule for combined packaging the adjuvant component and the nucleic acid encoding the antigen, the carrier molecule having a formula (I): P1 and P3 are different or identical to each other and represent a linear or branched hydrophilic polyethylene glycol (PEG) polymer chain, wherein the hydrophilic PEG polymer chain exhibits a molecular weight of 1 kDa to 100 kDa; P2 is a cationic or polycationic polypeptide, having a length of 3 to 100 amino acids, and comprising at least 2 cysteine residues; —S—S— is a (reversible) disulfide bond, wherein one of the sulfur positions of each of the disulfide bonds is provided by the at least 2 cysteine residues of the polypeptide of P2; L is an optional ligand and may be selected independent from the other from RGD, Transferrin, Folate, a signal peptide or signal sequence, a localization signal or sequence, a nuclear localization signal or sequence (NLS), an antibody, a cell penetrating peptide, TAT, a ligand of a receptor, cytokines, hormones, growth factors, small molecules, carbohydrates, mannose, galactose, synthetic ligands, small molecule agonists, inhibitors or antagonists of receptors, or RGD peptidomimetic analogues; and n is an integer, selected from a range of 1 to 50.