Patent ID: 9527895
Filing Date: 2016-12-27
CPC Classification: A61K,A61P,C07K

Claim Text:
1. A method of inducing cell death in a breast cancer cell, a leukemia cell, or a premalignant breast cell having a mutation in a deoxyribonucleic acid (DNA) repair protein, the method comprising administering a therapeutically effective amount of a composition comprising a cancer-specific proliferating cell nuclear antigen (caPCNA) peptide molecule, wherein the caPCNA peptide molecule consists of the amino acid sequence LGIPEAEY (SEQ ID NO:5), wherein the composition further comprises one or more agent selected from the group consisting of a cell penetrating factor, a cell surface targeting factor and a nuclear localization sequence, and wherein the caPCNA peptide molecule is optionally attached to said one or more agent selected from the group consisting of a cell penetrating factor, a cell surface targeting factor and a nuclear localization sequence.