Patent ID: 9288915
Filing Date: 2016-03-15
CPC Classification: G01N,G03F,H05K

Claim Text:
1. A method of fabricating a high pressure nano-liquid chromatography system on-a-chip, the method comprising: providing a substrate having a front first side and having a back second side; wherein the substrate has a layer disposed on the front first side; etching in two places the substrate from the back second side to form two holes and two diaphragm regions in the substrate adjacent to the holes; wherein the two diaphragm regions have the layer disposed on the front first side disposed on two diaphragms; from the front first side, etching the layer disposed on the front first side above the two diaphragm regions in the substrate to remove the layer over the diaphragms; patterning a sacrificial material on the front first side of a substrate to define a column region which covers the diaphragm regions, forming an encapsulant over the front first side of the substrate and the sacrificial material; wherein forming the encapsulant comprises depositing Parylene, and prior to deposition of Parylene, a moat is etched into the substrate adjacent to the channel to receive and anchor the deposited Parylene; etching through the diaphragm regions from the back second side to open an inlet hole and an outlet hole; removing the sacrificial material defining a column region through the inlet hole and the outlet hole to form the column region, wherein the method further comprises forming a epoxy passivating layer over the encapsulant, wherein the system provides a pressure limit of 1000 psi or greater.