Patent ID: 9248190
Filing Date: 2016-02-02
CPC Classification: A61K,A61P,C07D,C07F

Claim Text:
1. A method of inhibiting a signal transduction cascade in which JAK3 kinase plays a role, comprising contacting a cell expressing a receptor involved in such a signaling cascade with a compound having formula II, or a pharmaceutically acceptable salt thereof, in an amount effective to inhibit the signal transduction cascade wherein: X is fluoro or methyl; R is selected from the group consisting of hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkyl and substituted cycloalkyl; ring A is phenyl; Y is selected from the group consisting of a bond, —NR alk is methylene, ethylene, or n-propylene; R p is 0, 1, 2 or 3; each R Z q is 1, 2 or 3; each R R W is selected from the group consisting of C