Patent ID: 9493538
Filing Date: 2016-11-15
CPC Classification: C07K

Claim Text:
1. A complex consisting essentially of a human erythrocyte bound to one or more bispecific molecules, wherein each bispecific molecule comprises an antibody or antigen binding fragment thereof which binds to human complement receptor 1 (CR1) on the cell surface of the human erythrocyte linked to a soluble form of a picornavirus receptor selected from the group consisting of a coxsackie-adenovirus receptor (CAR), a poliovirus receptor (PVR) and an intracellular adhesion molecule-1 (ICAM-1) that is not naturally found on the human erythrocyte, and wherein the complex binds to a picornavirus selected from the group consisting of a coxsackie virus, a poliovirus and a rhinovirus, and inhibits viremia and penetration of the picornavirus into organs.