Patent ID: 9304137
Filing Date: 2016-04-05
CPC Classification: G01N,G16B

Claim Text:
1. A method of determining the likelihood that a pulmonary nodule in a subject is not lung cancer, comprising: (a) measuring an abundance of a plurality of transitions in a blood sample obtained from the subject, wherein each transition consists of a precursor ion m/z and a fragment ion m/z thereof, wherein said plurality of transitions comprise at least 3 transitions comprising a transition of ALQASALK (SEQ ID NO: 7) comprising m/z 401.25 and m/z 617.40, a transition of LGGPEAGLGEYLFER (SEQ ID NO: 24) comprising m/z 804.40 and m/z 913.40, and a transition of VEIFYR (SEQ ID NO: 25) comprising m/z 413.73 and m/z 598.30, and wherein said measuring is performed by selected reaction monitoring mass spectrometry; (b) calculating a probability of lung cancer score based on the abundance of a plurality transitions of step (a); and (c) ruling out lung cancer for the subject if the score in step (b) is lower than a pre-determined score.