Patent ID: 9365541
Filing Date: 2016-06-14
CPC Classification: A61K,C07D,Y02A

Claim Text:
1. A compound selected from the group consisting of: (S)-N-(1-(5-(6-methoxynaphthalen-2-yl)-1H-imidazol-2-yl)-7-(methylamino)-7-oxoheptyl)quinuclidine-4-carboxamide; (S)-N-(1-(5-(6-fluoronaphthalen-2-yl)-1H-imidazol-2-yl)-7-(methylamino)-7-oxoheptyl)quinuclidine-4-carboxamide; (S)-N-(1-(5-(3-(aminomethyl)phenyl)-1H-imidazol-2-yl)-7-(methylamino)-7-oxoheptyl)thiazole-5-carboxamide; (S)-N-(1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2-yl)-7-(methylamino)-7-oxoheptyl)quinuclidine-4-carboxamide; (S)-N-(1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2-yl)-7-(methylamino)-7-oxoheptyl)thiazole-5-carboxamide; (S)-7-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2-yl)-N-methyl-7-(4-cyanophenylsulfonamido)heptanamide; (S)-N-(1-(5-(4-(1H-pyrazol-5-yl)phenyl)-1H-imidazol-2-yl)-7-(methylamino)-7-oxoheptyl)thiazole-5-carboxamide; (S)-N-(7-(methylamino)-7-oxo-1-(5-(quinolin-6-yl)-1H-imidazol-2-yl)heptyl)thiazole-5-carboxamide; (S)-N-(1-(5-(1H-indol-5-yl)-1H-imidazol-2-yl)-7-(methylamino)-7-oxoheptyl)thiazole-5-carboxamide; (S)-N-(7-(methylamino)-7-oxo-1-(5-(2-oxo-1,2-dihydroquinolin-3-yl)-1H-imidazol-2-yl)heptyl)thiazole-5-carboxamide; (S)-N-(7-(methylamino)-7-oxo-1-(5-(quinolin-3-yl)-1H-imidazol-2-yl)heptyl)thiazole-5-carboxamide; (S)-N-(1-(5-(4-(1H-pyrazol-1-yl)phenyl)-1H-imidazol-2-yl)-7-(methylamino)-7-oxoheptyl)thiazole-5-carboxamide; (S)-N-(1-(5-(1H-indazol-5-yl)-1H-imidazol-2-yl)-7-(methylamino)-7-oxoheptyl)thiazole-5-carboxamide; (S)-N-(1-(5-(isoquinolin-7-yl)-1H-imidazol-2-yl)-7-(methylamino)-7-oxoheptyl)thiazole-5-carboxamide; (S)-N-(1-(5-(4-(1-methyl-1H-pyrazol-3-yl)phenyl)-1H-imidazol-2-yl)-7-(methylamino)-7-oxoheptyl)thiazole-5-carboxamide; (S)-N-(1-(5-(isoquinolin-7-yl)-1H-imidazol-2-yl)-7-(methylamino)-7-oxoheptyl)isothiazole-4-carboxamide; (S)-N-(7-(methylamino)-7-oxo-1-(5-(3-(trifluoromethyl)isoquinolin-7-yl)-1H-imidazol-2-yl)heptyl)thiazole-5-carboxamide; (S)-N-(1-(5-(3-methoxyisoquinolin-7-yl)-1H-imidazol-2-yl)-7-(methylamino)-7-oxoheptyl)thiazole-5-carboxamide; (S)-N-(1-(5-(isoquinolin-7-yl)-1H-imidazol-2-yl)-7-(methylamino)-7-oxoheptyl)isothiazole-5-carboxamide; (S)-1-isopropyl-N-(1-(5-(isoquinolin-7-yl)-1H-imidazol-2-yl)-7-(methylamino)-7-oxoheptyl)-1H-pyrazole-4-carboxamide; (S)-N-(1-(5-(isoquinolin-7-yl)-1H-imidazol-2-yl)-7-(methylamino)-7-oxoheptyl)-2-methylthiazole-5-carboxamide; (S)-N-(1-(5-(4-(1-methyl-1H-pyrazol-3-yl)phenyl)-1H-imidazol-2-yl)-7-(methylamino)-7-oxoheptyl)isothiazole-5-carboxamide; (S)-1-isopropyl-N-(1-(5-(4-(1-methyl-1H-pyrazol-3-yl)phenyl)-1H-imidazol-2-yl)-7-(methylamino)-7-oxoheptyl)-1H-pyrazole-4-carboxamide; (S)-2-methyl-N-(1-(5-(4-(1-methyl-1H-pyrazol-3-yl)phenyl)-1H-imidazol-2-yl)-7-(methylamino)-7-oxoheptyl)thiazole-5-carboxamide; (S)-N-(1-(5-(4-(1-methyl-1H-pyrazol-3-yl)phenyl)-1H-imidazol-2-yl)-7-(methylamino)-7-oxoheptyl)isothiazole-4-carboxamide; (S)-N-(1-(5-(4-(1-methyl-1H-pyrazol-3-yl)phenyl)-1H-imidazol-2-yl)-7-(methylamino)-7-oxoheptyl)-2-(pyrrolidin-1-ylmethyl)thiazole-5-carboxamide; (S)-1-methyl-N-(1-(5-(4-(1-methyl-1H-pyrazol-3-yl)phenyl)-1H-imidazol-2-yl)-7-(methylamino)-7-oxoheptyl)-1H-pyrazole-4-carboxamide; (S)-1-isopropyl-N-(1-(5-(3-methoxyisoquinolin-7-yl)-1H-imidazol-2-yl)-7-(methylamino)-7-oxoheptyl)-1H-pyrazole-4-carboxamide; (S)-N-(7-(methylamino)-7-oxo-1-(5-(4-(thiazol-2-yl)phenyl)-1H-imidazol-2-yl)heptyl)thiazole-5-carboxamide; (S)-N-(7-(methylamino)-7-oxo-1-(5-(4-(thiazol-4-yl)phenyl)-1H-imidazol-2-yl)heptyl)thiazole-5-carboxamide; and pharmaceutically acceptable salts, tautomers, stereoisomers thereof.