Patent ID: 9358307
Filing Date: 2016-06-07
CPC Classification: A61K,A61P,C07K

Claim Text:
1. Microparticles or nanoparticles for treatment of tumors comprising: a microparticulate or nanoparticulate core and, non-covalently or covalently attached to the surface thereof, the following components— (i) a targeting agent to the tumor or the tumor environment, optionally biotinylated, selected from the group consisting of: (a) an antibody to a tumor-associated antigen or to a peptide of such an antigen found on the surface of tumor cells; (b) an antibody to a receptor found on the surface of tumor cells; (c) an antibody to an antigen in the tumor environment; and (d) a ligand to a receptor found on the surface of tumor cells, wherein said antibody of (a), (b) or (c) is a chimeric, human or humanized mAb; and (ii) two or more inducers optionally biotinylated, that stimulates an innate immune response in the tumor environment, leading to tumor apoptosis, selected from the group consisting of mannose, mannan, lipopolysaccharide (LPS), a Toll-like Receptor (TLR) ligand, N-formyl-methionyl-leucyl-phenylalanine (fMLF or fMLP), Complement 3a (C3a), Complement 5a (C5a), and a C, CC, CXC or CX