Patent ID: 9271944
Filing Date: 2016-03-01
CPC Classification: A61K,A61P

Claim Text:
1. A water-based patch comprising an adhesive paste comprising a ketoprofen, an amine as a solubilizing agent for the ketoprofen, polyethylene glycol as an esterification inhibitor for the ketoprofen, cross-linking agent, and polyacrylic acid and/or salt thereof, wherein the amount of ketoprofen in the adhesive paste is 0.1 to 5% by weight, the amount of the amine in the adhesive paste is 0.5 to 10% by weight, the amount of the polyethylene glycol in the adhesive paste is 5 to 30% by weight, the amount of the cross-linking agent in the adhesive paste is 0.01 to 5% by weight, and the amount of polyacrylic acid and/or salt thereof in the adhesive paste is 1 to wherein the adhesive paste is prepared by the steps of: (1) solubilizing the ketoprofen in the amine to form a solubilized ketoprofen, (2) preparing a hydrated gel comprising the polyethylene glycol, cross-linking agent and polyacrylic acid and/or salt thereof in water, and (3) mixing the solubilized ketoprofen into the hydrated gel uniformly to generate a paste.