Patent ID: 9283188
Filing Date: 2016-03-15
CPC Classification: A61K,A61P,B01J

Claim Text:
1. A process of delivering functional compounds to a substrate, the process comprising: energizing an adsorbent with ultrasonic energy using an ultrasonic treatment system comprising an inlet end, an outlet end, and an ultrasonic waveguide assembly, wherein the ultrasonic waveguide assembly is a horn assembly comprising a horn member comprising two or more agitating members connected to the horn member and extending at least in part transversely outward from the outer surface of the horn member in longitudinally spaced relationship with each other, the agitating members and the horn member being constructed and arranged for dynamic motion of the agitating members relative to the horn member upon ultrasonic vibration of the horn member such to create a nodal region of the horn member; wherein the adsorbent is selected from the group consisting of alumina, silica, activated carbon, zeolites and combinations thereof; wherein the ultrasonic energy is produced by the ultrasonic waveguide assembly that is ultrasonically excited at a frequency of from about 15,000 Hz to about 100,000 Hz; introducing a fluid comprising at least one functional compound through the inlet end at a flow rate of from about 100 ml/min to about 20 L/min; wherein the at least one functional compound is selected from the group consisting of pharmaceuticals, xenobiotics, therapeutic agents, nutritional agents, anti-viral agents, anti-microbial agents, UV absorbers, signal agents, and combinations thereof; wherein the fluid is at a temperature of from about 20° C. to about 90° C. and has a pH of from about 2.0 to about 10.0; adsorbing the at least one functional compound to the surface of the energized adsorbent to form a carrier component of a delivery system, wherein the adsorbing step is conducted for a period of from about 10 seconds to about 10 minutes; removing the carrier component through the outlet end; wherein the pressure within the ultrasonic treatment system is from about 1 psi to about 10 psi; and contacting the carrier component with a substrate; wherein the substrate is selected from the group consisting of a product comprising a polyolefin polymer, the skin of a human or animal, and tissue inside a body of a human or animal.