Patent ID: 9403783
Filing Date: 2016-08-02
CPC Classification: A61P,C07C,C07D

Claim Text:
1. A method of manufacturing viloxazine or a pharmaceutically acceptable salt thereof, the method comprising: (a) reacting a compound of formula with N-benzyl-aminoethanol to form a diol compound of formula (b) contacting said diol compound in a solvent system with a base to generate a basic system; (c) contacting the basic system with a cyclization agent to produce a 2-substituted morpholine compound having the following formula: wherein Et is an ethyl group and Bn is a benzyl group; and, (d) removing the benzyl group from the 2-substituted morpholine compound to generate viloxazine, or a pharmaceutically acceptable salt thereof, with less than 2.5 ppm of an impurity selected from the group consisting of epichlorohydrin, and 1-(2-ethoxyphenoxy)-2,3-epoxypropane.