Patent ID: 9364432
Filing Date: 2016-06-14
CPC Classification: A61K,A61P

Claim Text:
1. A method of treating a delayed complication of a brain injury that deposits blood in a subarachnoid space of the brain, wherein the brain injury is mediated by decreased cerebral perfusion, comprising: a) providing a microparticulate composition comprising (i) a microparticulate suspension comprising a therapeutic amount of at least one therapeutic agent selected from the group consisting of a calcium channel antagonist, an endothelin (ET) receptor antagonist, and a transient receptor potential (TRP) channel antagonist, wherein the microparticulate formulation comprises a plurality of microparticles of a uniform distribution of microparticle size, and wherein each microparticle comprises a matrix, (ii) and a pharmaceutical carrier comprising an agent that affects viscosity of the suspension, b) administering the composition locally into a cerebral ventricle so that the microparticulate suspension flows from the cerebrospinal fluid (CSF) in the cerebral ventricle into the cerebrospinal fluid (CSF) in the subarachnoid space before releasing the therapeutic agent in the subarachnoid space without entering systemic circulation in an amount to cause unwanted side effects.