Patent ID: 9492375
Filing Date: 2016-11-15
CPC Classification: A61K,A61L

Claim Text:
1. An osteogenic composition for implantation at or near a target tissue site, the osteogenic composition having no demineralized bone particles and comprising: polymeric beads comprising immediate release beads and sustained release beads for delivering an isolated osteoinductive agent comprising a sterile growth factor at or near the target tissue site, the polymeric beads being biodegradable and synthetic; the polymeric beads comprising the growth factor, mPEG as an excipient in an amount of from about 0.05 wt. % to about 85 wt. %, a viscosity enhancing agent, degradation/release modifiers and sterile preservative free material; and a porous foam comprising layers for confining the polymeric beads at or near the target tissue site, wherein the immediate release beads and sustained release beads are disposed throughout the layers of the foam, the porous foam being biodegradable and containing a plurality of pores having a size between about 100 micrometers and about 350 micrometers at their widest points; and wherein the growth factor comprises bone morphogenic protein; wherein the amount of bone morphogenic protein is from 1 to 2 mg per cubic centimeter of said osteogenic composition; wherein the foam has a density of between about 0.2 g/cm wherein the porous foam comprises seeded hone cells or tissue.