Patent ID: 9290534
Filing Date: 2016-03-22
CPC Classification: C07H

Claim Text:
1. A gapped oligomeric compound comprising a contiguous sequence of linked monomeric subunits having two external regions and an internal region including one neutral internucleoside linkage covalently attaching a 3′ or 5′-terminal bicyclic nucleoside to the gapped oligomeric compound wherein the gapped oligomeric compound comprises from 12 to 16 linked monomeric subunits and is complementary to at least a portion of a target RNA wherein said neutral internucleoside linkage is a phosphotriester, methylphosphonate, MMI (3′-CH 2 —N(CH 3 )—O-5′), amide-3 (3′-CH 2 —C(═O)—N(H)-5′), formacetal (3′-O—CH 2 —O-5′) or a thioformacetal (3′-S—CH 2 —O-5′).