Patent ID: 9303070
Filing Date: 2016-04-05
CPC Classification: A61K,A61P,C07K,C12N

Claim Text:
1. A method for improving a protective effect or enhancing the efficacy of seasonal or pandemic influenza vaccine comprising administering to a subject an effective amount of a synthetic or recombinant multimeric polypeptide comprising multiple copies of a plurality of influenza virus peptide epitopes, wherein the multimeric polypeptide has three repetitions of nine conserved linear epitopes arranged in the following block copolymer structure [E1E1E1-E2E2E2-E3E3E3-E4E4E4-E5E5E5-E6E6E6-E7E7E7-E8E8E8-E9E9E9], wherein E1 is HA 354-372 (SEQ ID NO: 82), E2 is HA 91-108 (SEQ ID NO: 48), E3 is M1 2-12 (SEQ ID NO: 25), E4 is HA 150-159 (SEQ ID NO: 52), E5 is HA 143-149 (SEQ ID NO: 51), E6 is NP 206-229 (SEQ ID NO: 64), E7 is HA 307-319 (SEQ ID NO: 59 or 89), E8 is NP 335-350 (SEQ ID NO: 69), and E9 is NP 380-393 (SEQ ID NO: 70), and wherein the multimeric polypeptide is administered 1-5 weeks prior to administration of a seasonal or pandemic vaccine.