Patent ID: 9399075
Filing Date: 2016-07-26
CPC Classification: A61K,B82Y,C01G,Y10S,Y10T

Claim Text:
1. A composition comprising, a nanoparticle comprising a nanoparticulate transition metal oxide covalently functionalized with a silane-functionalized non-targeting zwitterionic moiety, wherein the nanoparticulate transition metal oxide is directly attached to the silane-functionalized non-targeting zwitterionic moiety without any intervening layer, and wherein the silane-functionalized non-targeting zwitterionic moiety comprises a reaction product of a precursor tri-alkoxy silane, wherein the precursor tri-alkoxy silane is selected from the group consisting of N-((2H-tetrazol-5-yl)methyl)-N,N-dimethyl-3-(trimethoxysilyl)propan-1-aminium, 2-(4-(3-(trimethoxysilyl)propylcarbamoyl)piperazin-1-yl)acetic acid, 3-(4-(3-(trimethoxysilyl)propylcarbamoyl)piperazin-1-yl)propanoic acid, and combinations thereof.