Patent ID: 9505760
Filing Date: 2016-11-29
CPC Classification: A61P,C07D

Claim Text:
1. A process for the preparation of a compound of formula 1, wherein X=H, alkyl, aryl, or heteroaryl; Y=H, alkyl, aryl, or heteroaryl; and wherein A=, alkyl, alkoxy, halo, or CF comprising the steps of: a. reacting a substituted aromatic aldehyde of formula 2 wherein R=H, alkyl, alkoxy, halo or CF with an olefin of formula 3 Z=electron withdrawing group in the presence of a catalyst with stirring and isolating a compound of formula 4; wherein Z=electron withdrawing group; and R=H, alkyl, alkoxy, halo or dihalo; b. adding pyridine to the compound of formula 4 of step 1 in the presence of an organic solvent under inert atmosphere followed by addition of an acetyl chloride and isolating an acetylated compound of formula 5; and wherein Z=electron withdrawing group; and R=H, alkyl, alkoxy, halo or CF c. reacting the acetylated compound of formula 5 of step 2 with 2-aminodimethyluracil in an organic solvent and a base and isolating a compound of formula 1