Patent ID: 9402898
Filing Date: 2016-08-02
CPC Classification: A61J,A61K,B65D,C07K

Claim Text:
1. A stable pharmaceutical formulation comprising: (i) an antibody at a concentration of from 20±3 mg/ml to 60±9 mg/ml that binds specifically to human angiopoietin 2 (human Ang-2), wherein the antibody comprises a heavy chain variable domain (HCVD) having the amino acid sequence of SEQ ID NO:18 and a light chain variable domain (LCVD) having the amino acid sequence of SEQ ID NO:20; (ii) histidine at a concentration of 10±1.5 mM; (iii) polysorbate 20 in an amount of 0.2% w/v±0.03% w/v; and (iv) sucrose in an amount of 10% w/v±1.5% w/v, wherein the formulation has a pH of 6±0.3, and at least 92% of the antibody has native conformation when the formulation is kept at about 45° C. for up to about 28 days.