Patent ID: 9494603
Filing Date: 2016-11-15
CPC Classification: G01N

Claim Text:
1. A method for monitoring a treatment against a hemoglobin disorder with an imbalance in the synthesis of hemoglobin chain in a subject in need thereof, said method comprising: contacting blood samples obtained from said subject, before and after administration of said treatment to said subject, with Alpha-Hemoglobin Stabilizing Protein (AHSP) to bind free monomeric alpha hemoglobin (α-Hb), detecting and/or quantifying the presence of AHSP-bound free monomeric α-Hb in said blood samples, and correlating said amount of the AHSP-bound free monomeric α-Hb with monitoring of a treatment against said hemoglobin disorder in said subject, wherein said treatment is determined to be effective for use as treatment of said hemoglobin disorder in said subject when the amount of the AHSP-bound free monomeric α-Hb detected and/or quantified in said subject after administration of said treatment is decreased as compared to the amount of the AHSP-bound free monomeric α-Hb detected and/or quantified in said subject before administration of said treatment and wherein said treatment is determined to be ineffective for use as treatment of said hemoglobin disorder in said subject when the amount of the AHSP-bound free monomeric α-Hb detected and/or quantified in said subject after administration of said treatment is the same or increased as compared to the amount of the AHSP-bound free monomeric α-Hb detected and/or quantified in said subject before administration of said treatment.