Patent ID: 9261506
Filing Date: 2016-02-16
CPC Classification: G01N

Claim Text:
1. A method for measuring the level of the KRT5, KRT7, TTF1, and TP63 proteins in a human biological sample of formalin-fixed tissue for diagnosis, evaluation, and/or treatment of lung cancer, comprising detecting and quantifying the amount of a KRT5 fragment peptide, a KRT7 fragment peptide, a TTF1 fragment peptide, and a TP63 fragment peptide in a protein digest prepared from said biological sample using mass spectrometry; and calculating the level of KRT5, KRT7, TTF1, and TP63 protein in said sample; wherein the KRT5 fragment peptide is the peptide of SEQ ID NO:2, the KRT7 peptide is the peptide of SEQ ID NO:3, the TTF1 peptide is the peptide of SEQ ID NO:8 and the TP63 peptide is the peptide of SEQ ID NO: 11, and wherein said amount is a relative amount or an absolute amount.