Patent ID: 9404126
Filing Date: 2016-08-02
CPC Classification: A61K,A61P,C07H,C12N

Claim Text:
1. A process for producing a composition comprising (i) a virus-like particle, wherein said virus-like particle is a virus-like particle of an RNA bacteriophage, and (ii) aggregated oligonucleotides, wherein said oligonucleotides comprise at their 5′ end at least 3 and at most 15 guanosine entities and at their 3′ end at least 3 and at most 15 guanosine entities, and wherein said oligonucleotides comprise 20-40 nucleotides, and wherein said oligonucleotides are packaged into said virus-like particle, said process comprising the steps of: (a) providing coat protein of said RNA bacteriophage; (b) providing a nucleotide composition comprising said aggregated oligonucleotides, wherein said nucleotide composition is obtainable by a process for producing said nucleotide composition, said process comprising the steps of: (c) generating a mixture, wherein said mixture comprises: (d) removing said agent from said mixture; and (e) allowing said coat protein to self assemble into a virus-like particle.