Patent ID: 9364554
Filing Date: 2016-06-14
CPC Classification: A61K,A61P,C07K

Claim Text:
1. A method for treating cancer, comprising administering to a human cancer patient in need of treatment for said cancer a therapeutically effective amount of an extracellular drug conjugate comprising a targeting moiety linked by a non-cleavable linker to a therapeutic agent, wherein the targeting moiety comprises an antibody that binds to human FXYD5, wherein the therapeutic agent acts on an extracellular target and is selected from the group consisting of CEN08-178 (3-O-digitoxigenin-L-riboside), CEN08-193 (3-O-isodigitoxigenin-L-xyloside), CEN08-243 ((3S)-3-N-methoxyamino-scillarenin-L-neo-4-amino-4-deoxy-xyloside), CEN08-244 ((3S)-3-N-methoxyamino-scillarenin-L-neo-4-amino-4-deoxyriboside), CEN09-106 (scillarenin-4-amino-4-deoxy-L-xylopyranoside), and CEN09-107 (scillarenin-4-amino-4-deoxy-L-ribopyranoside), and wherein the non-cleavable linker comprises polyethylene glycol (PEG).