Patent ID: 9463985
Filing Date: 2016-10-11
CPC Classification: A61K,A61Q,C01F,C01P,C02F

Claim Text:
1. A composition comprising an aluminum chlorohydrate salt, the aluminum chlorohydrate salt having at least 50 mole % Al 30 polyhydroxyoxoaluminum cation of all polyhydroxyoxoaluminum cations detectable by quantitative 27 Al NMR within the aluminum chlorohydrate salt, and a buffer, wherein the 27 Al NMR spectrum has a species distribution including at most 5 mole % Al 13 polyhydroxyoxoaluminum cation of all polyhydroxyoxoaluminum cations detectable by quantitative 27 Al NMR in the aluminum chlorohydrate salt, and wherein the aluminum chlorohydrate salt having at least 50 mole % Al 30 polyhydroxyoxoaluminum cation is obtained by: I) heating an aqueous solution containing a first aluminum salt and a buffer, wherein the first aluminum salt is present in a molar concentration of at least 0.75M, wherein the buffer is an amino acid or betaine and a molar ratio of buffer to aluminum is at least 0.1:1, at a temperature of 50° C. to 100° C. for a period of time of 1 hour to 6 hours to obtain a first aluminum salt solution; II) adding to the first aluminum salt solution an aqueous solution of an inorganic base to obtain a first aluminum chlorohydrate salt solution having an OH:Al molar ratio of at most 2.6:1, or optionally 2:1 to 2.6:1, and a pH of 2 to 5; and III) heating the first aluminum chlorohydrate salt solution at a temperature of 50° C. to 100° C. for a period of time of at least 8 hours to obtain a second aluminum chlorohydrate salt solution containing an aluminum chlorohydrate salt having at least 50 mole % Al