Patent ID: 9370531
Filing Date: 2016-06-21
CPC Classification: A61K,A61P,C12N,G01N,Y02A

Claim Text:
1. A method of treating Alzheimer's Disease pathology, which method comprises: selecting a subject who has Alzheimer's Disease pathology; and administering twice per week, to the selected subject an oligonucleotide or modified oligonucleotide containing at least one unmethylated B-class CpG dinucleotide motif at a dosage in a range of 0.2 mg to 20 mg per kilogram body weight of the selected subject, wherein said administering is effective to stimulate production of endogenously primed autoantibodies without co-administration of exogenous immunogens, said autoantibodies having binding specificity for one or more pathological neo-epitopes of amyloid beta or a beta-amyloid-associated protein, without stimulating production of autoantibodies having binding specificity for non-pathological epitopes of amyloid beta or a beta-amyloid-associated protein in the subject, thereby treating Alzheimer's Disease pathology.