Patent ID: 9265781
Filing Date: 2016-02-23
CPC Classification: A61K,A61P,C07H,C12P,C12Y

Claim Text:
1. A process for producing a particulate composition comprising anhydrous crystalline 2-O-α-D-glucosyl-L-ascorbic acid, said process comprising the following steps (a) to (e): (a) incubating an aqueous solution comprising cyclomaltodextrin glucanotransferase, ascorbic acid, and either liquefied starch or dextrin to obtain a reaction mixture and then further incubating the reaction mixture along with glucoamylase to obtain a resulting solution with a 2-O-α-D-glucosyl-L-ascorbic acid content of at least 27% but less than 35% by weight, on a dry solid basis; (b) purifying the resulting solution comprising 2-O-α-D-glucosyl-L-ascorbic acid to give a purified solution with a 2-O-α-D-glucosyl-L-ascorbic acid content of over 86% by weight, on a dry solid basis; (c) crystallizing 2-O-α-D-glucosyl-L-ascorbic acid from the purified solution in the presence of seed crystals in the amount of 0.1% to 5% (w/v) by a controlled cooling method or pseudo-controlled cooling method; (d) collecting the crystallized anhydrous 2-O-α-D glucosyl-L-ascorbic acid; and (e) ageing and drying the crystals to obtain the particulate composition which contains over 98.0% but below 99.9% by weight of 2-O-α-D-glucosyl-L-ascorbic has a degree of crystallinity of at least 90%, when calculated based on the powder X-ray diffraction profile of the particulate composition, and has a reducing power of the whole particulate composition of less than 1% by weight; wherein, in step (c), said controlled cooling method is defined by the equation T=T