Patent ID: 9474717
Filing Date: 2016-10-25
CPC Classification: A61K,A61P,Y02A

Claim Text:
1. Nanoparticles formed of linear, branched, or dendrimeric polymer selected from the group consisting of polyanhydrides, polyhydroxyacids, polyesters and copolymers thereof, having a mean diameter of between 60 nm and 400 nm, the nanoparticles comprising: T cell antigen selected from the group consisting of infectious disease antigens, cancer antigens, atopic disease antigens, alloantigens, and hapten, and an immunostimmulatory agent effective to enhance the immune response to the T cell antigen, wherein the immunostimulatory agent is selected from the group consisting of toll-like receptor (TLR) agonists, cytokine receptor agonists, CD40 agonists, Fc receptor agonists, CpG-containing nucleic acids, complement receptor agonists, wherein the T cell antigen is encapsulated within, and/or covalently bound to the polymer forming the nanoparticles and wherein the immunostimulatory agent is covalently bound to the nanoparticles or to a polymer from which the nanoparticles are formed.