Patent ID: 9486534
Filing Date: 2016-11-08
CPC Classification: A61K,A61P,C07D

Claim Text:
1. A method for treating a metabolic disorder in a subject in need thereof, the method comprising: administering to the subject an effective amount of a composition comprising a mixture of a niacin-EPA conjugate and a niacin-DHA conjugate wherein either DHA or EPA is linked to a moiety of formula I: wherein, each a, b, c, and d is independently —H, -D, —CH m is 0, 1, 2, or 3; each n, o, p, and q is independently 0 or 1; R each L is independently —O—, —S—, —S(O)—, —S(O) each g is independently 2, 3 or 4; each h is independently 1, 2, 3 or 4; each R each R each e is independently H or any one of the side chains of a naturally occurring amino acid; each R is independently —H, —C(O)—C R wherein the metabolic disorder is selected from the group consisting of atherosclerosis, dyslipidemia, hypertriglyceridemia, hypertension, heart failure, cardiac arrhythmias, coronary heart disease, acute myocardial infarction, secondary prevention of myocardial infarction, type 2 diabetes, insulin resistance, impaired glucose tolerance, hypercholesterolemia, stroke, hyperlipidemia, hyperlipoproteinemia, chronic kidney disease, intermittent claudication, hyperphosphatemia, carotid atherosclerosis, peripheral arterial disease, diabetic nephropathy, hypercholesterolemia in HIV infection, acute coronary syndrome (ACS), non-alcoholic fatty liver disease, cerebral arteriosclerosis, myocardial ischemia, and diabetic autonomic neuropathy.