Patent ID: 9273099
Filing Date: 2016-03-01
CPC Classification: A61K,A61P,C07K

Claim Text:
1. A method for promoting apoptosis of a neoplastic cell in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising a cross-linked polypeptide and a pharmaceutically acceptable carrier, wherein the cross-linked polypeptide is derived from a pro-apoptotic protein involved in a cellular apoptotic pathway, wherein the cross-linked polypeptide has the Formula (I): Formula (I) wherein: each R R wherein R R R K is O, S, SO, SO R n is an integer from 1-4; x is an integer selected from 2-10; each y is independently an integer from 0-100; z is an integer from 1-10; and each Xaa is independently an amino acid; wherein the polypeptide has a substantially alpha helical secondary structure in aqueous solution.