Patent ID: 9464291
Filing Date: 2016-10-11
CPC Classification: A61K,A61P,C12N

Claim Text:
1. A method of increasing the level of a platinum-based chemotherapeutic compound in a cell comprising reducing the level of a nucleic acid encoding GLI1 or reducing the level of GLI1 protein in the cell, wherein the level of a nucleic acid encoding GLI1 or the level of GLI1 protein is reduced by contacting the cell with an isolated nucleic acid selected from a small hairpin RNA (shRNA), a small interfering RNA (siRNA), a micro RNA (miRNA), an antisense polynucleotide, and a ribozyme, wherein the level of the platinum-based chemotherapeutic compound in the cell in which the level of a nucleic acid encoding GLI1 has been reduced or in which the level of GLI1 protein has been reduced is increased compared to the level of the platinum-based chemotherapeutic compound in a cell in which the level of a nucleic acid encoding GLI1 has not been reduced or in which the level of GLI1 protein has not been reduced.