Patent ID: 9295651
Filing Date: 2016-03-29
CPC Classification: A61K,A61P

Claim Text:
1. A drug-polymer nanoconjugate composition comprising drug-polymer nanoconjugate particles having a block copolymer coating, and an albumin coating; wherein the drug-polymer nanoconjugate particles comprise one or more drugs and one or more polymers, and the one or more drugs of the drug-polymer nanoconjugate particles are individually covalently bonded to initiation points of individual polymers of the drug-polymer nanoconjugate particles through ether or thioether moieties; the one or more polymers of the drug-polymer nanoconjugate particles comprise polyester, polycarbonate, polyphosphate, polysiloxane, polyphosphazane, polypeptide, or amino acid oligomers segments, or a combination thereof; the block copolymer coating comprises PEG and lactide blocks; and the block copolymer coating is coated with an amount of albumin effective to at least substantially prevent aggregation of the drug-polymer nanoconjugate particles when in contact with other drug-polymer nanoconjugates particles, wherein the ratio of the mass of albumin coating to the total mass of the drug-polymer nanoconjugate particles is about 2:1 to about 20:1; and wherein the composition has a diameter of about 2 nm to about 300 nm and a mass of less than 2 wt. % of total drugs that are not covalently bonded to the polymer.