Patent ID: 9480701
Filing Date: 2016-11-01
CPC Classification: A61K,A61P,C08B,Y02A

Claim Text:
1. Chemically modified heparin having an antifactor IIa activity and an antifactor Xa activity, wherein the antifactor IIa activity is up to 10 IU/mg and the antifactor Xa activity of up to 10 IU/mg, wherein the chemically modified heparin has a weight average molecular weight from about 6.5 to about 9.5 kDa, wherein the polysaccharide chains: (i) retain at least 90% of the sulfate groups of the corresponding native heparin; (ii) have a reduction in chemically intact pentasaccharide sequences providing an antithrombin mediated anticoagulant effect, when compared to the polysaccharide chains of native heparin; (iii) have a reduction in unsulfated iduronic and/or glucuronic acid units when compared to native heparin; and wherein the predominant disaccharide of the polysaccharide has the chemical structure: wherein R′ is a threonate residue and n is an integer of from 2 to 25, such that it comprises from 2 to 25 disaccharide units corresponding to molecular weights from 1.2 to 15 kDa.