Patent ID: 9522955
Filing Date: 2016-12-20
CPC Classification: A61P,C07K,G01N

Claim Text:
1. A method of treating cancer in a host comprising administering to the host, in an amount effective to treat cancer in the host, a composition comprising a population of syngeneic T cells, wherein the cells express a chimeric antigen receptor (CAR), wherein the CAR comprises: (a) an amino acid sequence comprising SEQ ID NO: 3, 4, or 7; and (b) an amino acid sequence comprising SEQ ID NO: 5, 6, 8, or 9, wherein the cancer expresses vascular endothelial growth factor receptor-2 (VEGFR-2), and wherein (i) the host is a human and the CAR further comprises the amino acid sequence of SEQ ID NO: 1 or (ii) the host is a mouse and the CAR further comprises the amino acid sequence of SEQ ID NO: 2.