Patent ID: 9290509
Filing Date: 2016-03-22
CPC Classification: C07D

Claim Text:
1. A process for making a bisglycidyl ether of an isohexide, comprising the steps of forming a diallyl isohexide intermediate, by first forming a conjugate base of an isohexide stereoisomer through reacting the isohexide stereoisomer with a Brønsted base whose conjugate acid has an acid dissociation constant pKa greater than 16 in a nonaqueous solvent system and at a temperature of 25 degrees Celsius or less, then reacting the conjugate base of the isohexide stereoisomer with allyl bromide added gradually at a rate of not more than 13.3 percent per minute to form the diallyl isohexide intermediate; and reacting the diallyl isohexide intermediate with at least two mole equivalents of meta-chloroperbenzoic acid, wherein the diallyl isohexide intermediate is added to the meta-chloroperbenzoic acid in a controlled manner over a period of time.