Patent ID: 9474463
Filing Date: 2016-10-25
CPC Classification: A61B,G16H

Claim Text:
1. A method to evaluate a human subject for the presence or absence of thoracic outlet syndrome (TOS) which method comprises: obtaining a first set of magnetic resonance imaging(MRI) slices in each of three planes, in the absence of a contrast agent, with the subject in a supine position with both arms in a neutral position by the side of the body, wherein the obtaining the first set comprises: obtaining a second set of MRI slices in one or more planes, in the absence of the contrast agent, with the subject in a supine position with both arms placed in abduction and external rotation, by imaging the upper chest and neck, and the supraclavicular fossa region on the affected side(s), wherein the obtaining the second set comprises obtaining a gradient echo T1, spin echo T1, or fast spin echo T2-weighted sequence that comprises sagittal slices that cover the scalene triangle costoclavicular space and retropectoralis space on the affected side(s); administering a diluted contrast agent comprising 50% gadolinium into a vein on a first side of the subject such that the contrast agent enters arteries on both sides of the subject and veins on both sides of the subject; obtaining a contrast-enhanced magnetic resonance angiogram (MRA) and a magnetic resonance venogram (MRV), each of which image, in the subject, the contrast agent delivered by the administering, the MRA comprising slices imaging the subclavian and axillary arteries on both sides of the subject, the MRV comprising slices imaging the subclavian, axillary, and brachiocephalic veins on both sides of the subject; creating a first three-dimensional model of the brachial plexus on the affected side(s) based on the first set of MRI slices; creating a second three-dimensional model of the arteries on the affected side(s) based on the slices from the MRA; and creating a third three-dimensional model of the veins on the affected side(s) based on the slices from the MRV; wherein the MRI slices are configured to be analyzed for determining the presence or absence of stenosis, wherein the MRA is configured to be analyzed for determining the presence or degree of stenosis, external compression, or aneurysm, if any, in each of the subclavian and the axillary arteries, and the MRV is configured to be analyzed for determining the presence or degree of stenosis or external compression in each of the subclavian, axillary, and brachiocephalic veins on both sides of the subject by assessing vascular contrast enhancement, on both sides of the subject, produced by the contrast agent delivered by the administering of the contrast agent into the vein on the first side; and wherein the MRI slices, the MRA and the MRV are configured for determining the presence or absence of TOS based on an evaluation of the first three-dimensional model, the second three-dimensional model, and the third three-dimensional model.