Patent ID: 9248200
Filing Date: 2016-02-02
CPC Classification: A61K,A61P,B82Y,C08B,C08G,C08L

Claim Text:
1. A micellar nanocomplex comprising: trastuzumab; and a conjugate of: the micellar nanocomplex having the polethylene glycol conjugated at the C6 and/or the C8 position of the A ring of the flavonoid by attachment of the polyethylene glycol via reaction of the free aldehyde group with the C6 and/or C8 position of the A ring of the flavonoid, and exhibiting an anti-cancer effect on a cell as a result of a synergistic effect between the anti-cancer effect of the trastuzumab and the anti-cancer effect of the flavonoid, wherein when the flavonoid is monomeric (−)-epigallocatechin gallate, the micellar nanocomplex further comprises non-conjugated oligomeric (−)-epigallocatechin gallate in an inner core of the micellar nanocomplex, wherein the trastuzumab is complexed with either the conjugated or non-conjugated oligomeric (−)-epigallocatechin gallate, whichever is present.