Patent ID: 9353186
Filing Date: 2016-05-31
CPC Classification: A61K,A61P,C07K

Claim Text:
1. Antibody Mat3 or an antigen-binding fragment thereof which antagonizes prolactin receptor (PRLR)-mediated signaling, wherein the variable heavy chain comprises the sequences of CDR1, CDR2, and CDR3 corresponding to SEQ ID NOS: 5, 6, and 7, respectively, and the variable light chain comprises the sequences of CDR1, CDR2, and CDR3 corresponding to SEQ ID NOS: 8, 9, and 10, respectively, and wherein the antibody or antigen-binding fragment thereof comprises an antigen-binding region that binds specifically to one or more regions of the extracellular domain of human PRLR, said human PRLR is depicted by the amino acid sequence from position 1 to 210 of SEQ ID NO: 12.