Patent ID: 9314486
Filing Date: 2016-04-19
CPC Classification: A61K,A61L,Y02A

Claim Text:
1. A method of treating a mammalian subject having a damaged central nervous system with a reduced function by engrafting mammalian ex vivo cells at the site of injury, the method comprising the steps of: (a) administering to the subject an effective amount of an agent that confers a growth disadvantage to at least a subset of endogenous nerve cells at the site of engraftment, wherein the agent is radiation; (b) administering to the subject an effective amount of a mitogenic stimuli for the ex vivo cells; and (c) administering the ex vivo cells to the subject, wherein the ex vivo cells engraft at the site of injury and repopulate at least a portion of the site with the ex vivo cells, wherein the repopulated ex vivo cells supplement the function and replace at least a subset of endogenous nerve cells, thereby treating the subject.