Patent ID: 9346798
Filing Date: 2016-05-24
CPC Classification: A61P,C07D

Claim Text:
1. A compound of Formula I, or a pharmaceutically acceptable salt thereof, wherein: R X is O; Each of W, Y and Z are independently CR U is absent; V is absent, —C(R R R R A is a five to six membered aryl group, a five to six membered heteroaryl group, a three to six membered cycloalkyl group or a three to six membered heterocycloalkyl group, wherein the heteroaryl or heterocycloalkyl group has from one to three heteroatoms independently selected from O, N or S, and where the aryl, heteroaryl cycloalkyl or heterocycloalkyl group may be unsubstituted or substituted with from 1 to 4 substituents independently selected from halo, —CF B is a five to six membered aryl group, a five to six membered heteroaryl group, a three to six membered cycloalkyl group or a three to six membered heterocycloalkyl group, wherein the heteroaryl or heterocycloalkyl group has from one to three heteroatoms independently selected from O, N or S, and where the aryl, heteroaryl cycloalkyl or heterocycloalkyl group may be unsubstituted or substituted with from 1 to 4 substituents independently selected from halo, —CF each R each R each R each R each R each n is independently 0 to 3; each m is independently 1 to 3, and each p is independently 0 to 3, provided that the compound of Formula I is not N-(5-chloro-1,3-thiazol-2yl)-4-(2-chloro-4-(trifluoromethyl)phenyl)-3,4-dihydro-2H-1,4-benzoxazine-7-sulfonamide; 4-(2-chloro-4-(trifluoromethyl)phenyl)-N-(3-methyl-1,2,4-oxadiazol-5-yl)-3,4-dihydro-2H-1,4-benzoxazine-7-sulfonamide; 4-(2-chloro-4-(trifluoromethyl)phenyl)-N-(3-cyano-1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-1,4-benzoxazine-7-sulfonamide; 4-(2-chloro-4-(trifluoromethyl)phenyl)-N-(5-methyl-1,2,4-oxadiazol-3-yl)-3,4-dihydro-2H-1,4-benzoxazine-7-sulfonamide; 4-(2-chloro-4-(trifluoromethyl)phenyl)-N-(5-methyl-4-(trifluoromethyl)-1,3-thiazol-2-yl)-3,4-dihydro-2H-1,4-benzoxazine-7-sulfonamide; 4-(2-chloro-4-(trifluoromethyl)phenyl)-N-1,3-thiazol-5-yl-3,4-dihydro-2H-1,4-benzoxazine-7-sulfonamide; 4-(2-chloro-4-(trifluoromethyl)phenyl)-N-(5-methyl-3-isoxazolyl)-3,4-dihydro-2H-1,4-benzoxazine-7-sulfonamide; 4-(2-chloro-4-(trifluoromethyl)phenyl)-N-(1-methyl-1H-imidazol-4-yl)-3,4-dihydro-2H-1,4-benzoxazine-7-sulfonamide; 4-(2-chloro-4-(trifluoromethyl)phenyl)-N-(5-methyl-1,3,4-oxadiazol-2-yl)-3,4-dihydro-2H-1,4-benzoxazine-7-sulfonamide; 4-(2-chloro-4-(trifluoromethyl)phenyl)-N-(2,4-difluorophenyl)-3,4-dihydro-2H-1,4-benzoxazine-7-sulfonamide; 4-(2-chloro-4-(trifluoromethyl)phenyl)-N-4-isoxazolyl-3,4-dihydro-2H-1,4-benzoxazine-7-sulfonamide; 4-(2-chloro-4-(trifluoromethyl)phenyl)-N-1,3,4-oxadiazol-2-yl-3,4-dihydro-2H-1,4-benzoxazine-7-sulfonamide; 4-(2-bromo-4-(trifluoromethyl)phenyl)-N-1,3-thiazol-5-yl-3,4-dihydro-2H-1,4-benzoxazine-7-sulfonamide; or 4-(2-(1,2,3,6-tetrahydro-4-pyridinyl)-4-(trifluoromethyl)phenyl)-N-1,3-thiazol-5-yl-3,4-dihydro-2H-1,4-benzoxazine-7-sulfonamide.