Patent ID: 9248096
Filing Date: 2016-02-02
CPC Classification: A61K,A61P

Claim Text:
1. A method for preparing tablets of a sustained release composition comprising: (a) dissolving or dispersing one or more active ingredients and one or more lipids in a solvent to produce an active-containing solution or suspension, wherein said solvent is present in a sufficient amount to form said solution or said suspension; (b) mixing said active-containing solution or suspension with at least one spheronizing or bulking agent to produce a mixture; and (c) forming said mixture into tablets comprising a matrix that comprises said lipids and said spheronizing or bulking agent, wherein said active ingredients are encapsulated within said matrix; wherein said sustained release composition exhibits an in vitro dissolution rate of said active ingredients as measured by a USP Dissolution Apparatus II of about 10% to 50% after about 2 hours, about 25% to 90% after about 4 hours, more than about 60% after about 12 hours, and more than about 75% after about 16 hours, wherein said steps (a)-(c) are performed at temperatures not exceeding the melting point of said one or more lipids, wherein said sustained release composition has an in vitro dissolution rate of said active ingredients as measured by a USP Dissolution Apparatus II of no more than 10% during the first 1 to 5 minutes, wherein said sustained release composition comprises 0.5 to 15 weight percent of said lipids.