Patent ID: 9388469
Filing Date: 2016-07-12
CPC Classification: A61K,C07K,C12Q,G01N

Claim Text:
1. A method of identifying the presence and type of lymphoma cells in an individual and treating the individual for lymphoma, the method comprising: (a) providing a sample of cells from the individual; (b) contacting the sample of cells with an antibody or antigen-binding fragment capable of selectively binding to Sox11 protein, or a nucleic acid molecule capable of selectively binding to a nucleic acid molecule encoding Sox11 protein; (c) determining the amount of Sox11 protein and/or mRNA in the sample of cells; and (d) determining the presence and type of lymphoma cells in the individual based on the amount of Sox11 protein and/or mRNA in the sample of cells, wherein nuclear expression of Sox11 protein and/or mRNA is indicative of the individual having lymphoma cells, wherein the lymphoma is a mantle cell lymphoma (MCL); and (e) initiating anti-MCL therapy based on the determination in step (d).