Patent ID: 9481878
Filing Date: 2016-11-01
CPC Classification: A61K,B82Y,C07K,C12N,C12Y

Claim Text:
1. A complex comprising: a) a first fusion protein comprising a toxin attached to a DDD (dimerization and docking domain) moiety from human protein kinase A (PKA) regulatory subunit RIα, RIβ, RIIα or RIIβ, wherein the toxin is selected from the group consisting of ranpirnase (Rap), saporin, diphtheria toxin, gelonin, Pseudomonas exotoxin; and b) a second fusion protein comprising an antibody or antigen binding antibody fragment attached to an AD (anchoring domain) moiety from an AKAP protein, wherein the antibody or antibody fragment is selected from the group consisting of hR1 (anti-IGF-1R), hPAM4 (anti-mucin), hA20 (anti-CD20), hLL1 (anti-CD74), hLL2 (anti-CD22), hMN-14 (anti-CEA), hMN-15 (anti-CEA) and hRS7 (anti-EGP-1); wherein two copies of the DDD moiety form a dimer that binds to the AD moiety to form the complex.