Patent ID: 9527907
Filing Date: 2016-12-27
CPC Classification: A61K,A61P,C07K

Claim Text:
1. A method of treating endometriosis in a patient, the method comprising administering to a patient a therapeutically effective amount of a medicament comprising a specific binding member which binds the ED-A isoform of fibronectin operably linked to IL-10, wherein said specific binding member is an anti-EDA antibody comprising: (i) a VH domain comprising comprising a framework and a set of complementarity determining regions HCDR1, HCDR2 and HCDR3, wherein HCDR1 comprises amino acid sequence SEQ ID NO: 42, HCDR2 comprises amino acid sequence SEQ ID NO: 56, HCDR3 Comprises amino acid sequence SEQ ID NO: 60; and (ii) a VL domain comprising a set of complementarity determining regions LCDR1, LCDR2 and LCDR3 and a framework, wherein LCDR1 has amino acid sequence SEQ ID NO: 102, LCDR2 has amino acid sequence SEQ ID NO: 114, and LCDR3 has amino acid sequence SEQ ID NO: 118.