Patent ID: 9259390
Filing Date: 2016-02-16
CPC Classification: A61K,A61P

Claim Text:
1. A drug delivery composition, comprising: a) a benzimidazole derivative having the formula: wherein R 3 is selected from the group consisting of H, carboxyl (—CO 2 H), hydroxyl, amino, chloro, difluormethoxy, benzoyl, phenyl-thio, pyridinyl, propyl-thio, diphenyl, 5-methoxy, fluorophenylmethyl-2-chloro, propenyl, chloropropyl or esters (—CO 2 R 4 ) wherein R 4 is selected from the group consisting of alkoxy, haloalkyl, alkenyl, and cycloalkyl, wherein the alkyl groups have from 1-8 carbons, or CH 3 CH 2 (OCH 2 CH 2 )n-, or CH 3 CH 2 CH 2 (OCH 2 CH 2 CH 2 )n-, or (CH 3 ) 2 CH(OCH(CH 3 )CH 2 )n-, wherein n is from 1-3 wherein R 1 is OH, Cl, SH, carbamate or piperidin-4-yl, and R 2 is hydrogen, α-methylvinyl, 3-chloropropyl or piperidin-4-yl, or the pharmaceutically effective organic or inorganic salts thereof, or mixtures thereof; b) an oil; c) a surfactant; d) a cosurfactant; and e) a dipolar aprotic solvent, wherein said delivery composition forms as a parenterally-deliverable microemulsion having a droplet diameter of about 478 nm to less than 500 nm.