Patent ID: 9371361
Filing Date: 2016-06-21
CPC Classification: A61P,C07K,C12P

Claim Text:
1. A method of producing type A crystalline form of FR901228: comprising: culturing a producing strain for FR901228 in a medium to which at least one amino acid selected from the group consisting of L-arginine, an acid addition salt of L-arginine, L-histidine, an acid addition salt of L-histidine, L-cystine, an acid addition salt of L-cystine, L-cysteine, and an acid addition salt of L-cysteine, has been added; isolating and purifying FR901228 from the medium; and crystallizing to obtain the type A crystalline form of FR901228 from a solution of FR901228 comprising ethanol and water, or acetone and water.