Patent ID: 9475888
Filing Date: 2016-10-25
CPC Classification: A61K,A61P,C08B

Claim Text:
1. A chemically modified glycosaminoglycan, which glycosaminoglycan is selected from the group consisting of heparin and heparan sulfate, which chemically modified glycosaminoglycan has an antifactor IIa activity and an antifactor Xa activity, with the antifactor IIa activity being less than 10 IU/mg and the antifactor Xa activity being less than 10 IU/mg, the chemically modified glycosaminoglycan having a weight average molecular weight (Mw) from about 4.6 to about 6.9 kDa, and wherein, in the chemically modified glycosaminoglycan: the polysaccharide chains have from 2 to 20 disaccharide units corresponding to molecular weights between 1.2 and 12 kDa; the polysaccharide chains are essentially free of chemically intact non-sulfated iduronic and/or glucuronic acids from pentasaccharide sequences mediating the anticoagulant effect of heparin and heparin sulfate; the predominantly occurring disaccharide is (Formula I) the distribution of molecular weights of the polysaccharides in the chemically modified glycosaminoglycan are expressed as cumulative % of weight according to the following table: