Patent ID: 9439863
Filing Date: 2016-09-13
CPC Classification: A61K

Claim Text:
1. A method of treating a sexually transmitted infection/disease and/or a method of prophylaxis against a sexually transmitted infection/disease comprising intravaginal administration of a pharmaceutical dosage form comprising a pharmaceutical compound and a microsphere comprising a pectin (PEC) framework providing rigidity to the microsphere, porcine gastric mucin (MUC) substantially encapsulated and/or embedded in the pectin (PEC) framework, and polyethylene glycol (PEG), to a person in need thereof, wherein, in use, the PEG provides a neutral charge facilitating passage of the microspheres across vaginal mucus lining the target site, the target site located on the vaginal wall, and wherein the PEC and MUC modulate release of the pharmaceutical compound at the target site in a pH-dependent manner, wherein an increase in pH facilitates an increase in the release rate of the pharmaceutical compound from the microsphere and wherein a decrease in pH facilitates a decrease in the release rate of the pharmaceutical compound from the microsphere.