Patent ID: 9284548
Filing Date: 2016-03-15
CPC Classification: C07K,C12N,C40B

Claim Text:
1. A method for identifying a high affinity adaptor molecule capable of redirecting the specificity of a circulating antibody, the method comprising: (a) providing a randomized library encoding a population of non-naturally occurring candidate targeting peptides, wherein each targeting peptide comprises one or more D-amino acids; (b) selecting a non-naturally occurring targeting peptide from the library which binds with high affinity and/or selectivity to a cytokine or growth factor target molecule; (c) linking the non-naturally occurring targeting peptide to a ligand moiety via a linking moiety to form a candidate adaptor molecule, wherein the ligand moiety comprises a glycan moiety or a peptidomimetic thereof; and (d) evaluating the ability of the candidate adaptor molecule to redirect the specificity of the circulating antibody to the cytokine or growth factor target molecule; thereby identifying the adaptor molecule.