Patent ID: 9505747
Filing Date: 2016-11-29
CPC Classification: C07C,C07D,C07F,C07K

Claim Text:
1. A process for preparing a compound of the formula or a salt or solvate thereof; wherein Ar Ar L is selected from the group consisting of where p is an integer from about 1 to about 3, m is an integer from about 1 to about 4, and * indicates the points of attachment; R R Y is acyloxy or R R R R R R n is 1, 2, 3, or 4; wherein the process comprises the step of treating a compound of formula A with triethylsilyl chloride and imidazole in an aprotic solvent, where R or the step of treating a compound of formula B with a base and a compound of the formula ClCH or the steps of a) preparing a compound of formula (E1) from a compound of formula (E), where X and b) treating a compound of formula C under reducing conditions in the presence of the compound of formula E1, where R where R 2 is selected from the group consisting of optionally substituted alkyl and optionally substituted cycloalkyl; or the step of treating a compound of formula D with a hydrolase enzyme or with a trialkyltin hydroxide, where R where R 2 is selected from the group consisting of optionally substituted alkyl and optionally substituted cycloalkyl; or the step of treating a compound of formula F1 with a non-basic fluoride reagent or the step of treating a compound of formula G1 with an acylating agent of formula R or the steps of c) forming an active ester intermediate from a compound of formula H1 and d) reacting the active ester intermediate with a compound of the formula I or a combination thereof.