Patent ID: 9505804
Filing Date: 2016-11-29
CPC Classification: A61K,A61P,C07K

Claim Text:
1. A peptidomimetic macrocycle comprising an amino acid sequence which is at least about 90% identical to an amino acid sequence selected from the group consisting of SEQ ID NOs: 10-457, wherein the peptidomimetic macrocycle has the formula: or a pharmaceutically acceptable salt thereof, wherein: each A, C, D, and E is independently an amino acid; each B is independently an amino acid, [NH-L 3 -CO—], [—NH-L 3 -SO 2 —], or [—NH-L 3 -]; each R each R each R each L and L′ is independently a macrocycle-forming linker of the formula -L each L each R each R each R each v is independently an integer from 1-1000; each w is independently an integer from 1-1000; u is an integer from 1-10; each x, y and z is independently an integer from 0-10; and each n is independently an integer from 1-5; wherein a first C-terminal amino acid represented by E comprises a hydrophobic side chain, or when a w>1 a first or a second C-terminal amino acid represented by E comprises a hydrophobic side chain; and wherein the peptidomimetic macrocycle or pharmaceutically acceptable salt thereof is not any of SEQ ID NOs: 728, 729, 737-740, 826, 828, 839-841, 857, 860, 864, 866, 868, 872, 881, 884, 897, 911, 914, 915, 920, 921, 923, 926-942, 960-973, 975-977, 1013-1016, 1069, 1070, 1076, 1088, 1089, 1095-1124, 1127-1132, 1136-1139, 1142, 1144, 1149-1151, 1172, 1173, 1178-1201, 1206-1210, 1214-1216, 1246-1252, 1256-1266, 1270, 1272-1278, 1284, 1288, 1289, 1295-1297, 1327, 1336-1339, 1344, 1345, 1360, 1362, 1363, 1369, 1378-1380, 1391, 1392, 1419-1421, 1430, 1431, 1434, 1436, 1438, 1451, 1453, 1473, 1478, or 1502.