Patent ID: 9296673
Filing Date: 2016-03-29
CPC Classification: C07C,C07D

Claim Text:
1. A process for the synthesis of 6-hydroxy-5-arylbicyclo[2.2.2]octan-2-one compounds, the compounds of the formula (II): wherein the compound of formula (II) is formed in a reaction mixture in diastereomerically enriched form; wherein the major diastereoisomer is (1R*,4R*,5S*,6S*)-6-hydroxy-5-arylbicyclo[2.2.2]octan-2-one: said process comprising a cyclization of a compound of formula 4: wherein Ar represents an aryl group; and —OR wherein said cyclization is performed in presence of: wherein said compound of formula (II) is isolated from the reaction mixture by solid-liquid separation.