Patent ID: 9487523
Filing Date: 2016-11-08
CPC Classification: A01N,C07D,C07F

Claim Text:
1. A process for making a compound of Formula I or a pharmaceutically acceptable salt thereof, wherein: X is selected from —C(R Y is N; R R comprising initiating the reaction of a compound of Formula F wherein E E PG is a nitrogen protecting group, in an organic phase, in the presence of a bis-quaterary cinchona alkaloid salt and an inorganic base in an aqueous phase, to form a biphasic medium comprising the aqueous phase and organic phase, to make a compound of Formula G when E deprotecting the compound of Formula H to yield the compound of Formula C optionally isolated as a salt, and coupling the compound of Formula C with a compound of Formula B optionally as a salt, under conditions for an amide bond formation between an acid and an amine to yield a compound of Formula I.