Patent ID: 9296801
Filing Date: 2016-03-29
CPC Classification: A61K,A61P,C07K

Claim Text:
1. A fusion protein having improved bioactivity comprising a first polypeptide fusion partner and a second polypeptide fusion partner wherein the first fusion partner is linked to the second fusion partner by a mucin-domain polypeptide linker, wherein the first fusion partner is: sTNFR2, CTLA4, TACI, LFA, IL-1RI, IL-1RAcP, VEGF receptor, TPO receptor agonists, EPO receptor agonists, GLP-1, or exendin-4, and wherein the second fusion polypeptide comprises all or a portion of an immunoglobulin comprising an Fc region, and wherein the mucin domain polypeptide linker comprises at least one domain of tandem repeat comprising SEQ ID NO: 14 and wherein the improved bioactivity of the fusion protein is increased half-life, and wherein the half-life of the fusion protein is improved as compared to fusion of the first polypeptide fusion partner and the second polypeptide fusion partner in the absence of the mucin-domain polypeptide linker.