Patent ID: 9394341
Filing Date: 2016-07-19
CPC Classification: C07K

Claim Text:
1. A method of preparing eptifibatide, comprising the steps of: preparation of eptifibatide resin by a solid phase polypeptide synthesis reaction, acidolysis of the eptifibatide resin to obtain crude linear peptide eptifibatide, oxidation of the crude linear peptide eptifibatide to obtain crude eptifibatide, and purification and salt exchange of the crude eptifibatide to obtain finished eptifibatide, wherein the step for preparing the eptifibatide resin by the solid phase polypeptide synthesis reaction comprises successively coupling a protected amino acid or fragment corresponding to the following sequence on amino resin through a solid phase coupling synthesis method to obtain the eptifibatide resin: where,