Patent ID: 9526600
Filing Date: 2016-12-27
CPC Classification: A61C,A61K,A61L

Claim Text:
1. A biodegradable stent for selectively guided tissue regeneration in treating a periodontal defect adjacent to a root of a tooth, the biodegradable stent comprising a porous coronal portion having a pore size between about 10 μm to about 200 μm and a non-porous transverse portion, the coronal portion having a first surface configured to contact at least a portion of the root of the tooth, the first surface having a zone configured to immediately release a therapeutic agent, the therapeutic agent comprising clonidine, the coronal portion having a second surface configured to contact at least a portion of the periodontal defect, the second surface having a zone configured to provide sustained release of the therapeutic agent, the transverse portion above the coronal portion and substantially perpendicular to it, the transverse portion having a first surface configured to contact a portion of the tooth and a second surface configured to extend away from the tooth and over a portion of the periodontal defect to maintain a space between gingival epithelium tissue and periodontal ligament tissue, wherein the biodegradable stent reduces ingrowth of gingival epithelium cells and permits ingrowth of periodontal ligament cells, wherein all of the first surface of the coronal portion conforms to the tooth and/or tooth root, and the stent comprises a hardening gel having a pre-dosed modulus of elasticity of about 1×10 4 to about 3×10 5 dynes/cm 2 and a post-dosed modulus of elasticity between about 1×10 4 to about 2×10 6 dynes/cm 2 and the stent comprises a plasticizer comprising mPEG, and is configured to attach to the tooth by an elastic band coated with an adhesive and comprising the therapeutic agent.