Patent ID: 9274119
Filing Date: 2016-03-01
CPC Classification: A61K,A61P,C07K,G01N

Claim Text:
1. An isolated monoclonal antibody selected from the group consisting of (a) and (b): (a) an antibody comprising a heavy chain variable region having CDR1 having the amino acid sequence represented by SEQ ID NO: 40, CDR2 having the amino acid sequence represented by SEQ ID NO: 41, and CDR3 having the amino acid sequence represented by SEQ ID NO: 42 and comprising a light chain variable region having CDR1 having the amino acid sequence represented by SEQ ID NO: 43, CDR2 having the amino acid sequence represented by SEQ ID NO: 44, and CDR3 having the amino acid sequence represented by SEQ ID NO: 45; and (b) an antibody which blocks the binding of the antibody of (a) to CLDN6, wherein said antibody selected from the group consisting of (a) and (b) has cytotoxicity, and has 50% or less avidity for CLDN9 as set forth in SEQ ID NO: 48 compared with its avidity for CLDN6.