Patent ID: 9226939
Filing Date: 2016-01-05
CPC Classification: A61K,A61P

Claim Text:
1. A method of treating sepsis by inhibiting the cytotoxic activity of extracellular histones in a subject having sepsis, said method comprising administering an effective amount of a polyanion to said subject, wherein the polyanion does not have substantial anticoagulant activity; and wherein the polyanion is a polyanionic oligosaccharide having the general structure (I): wherein the polyanion does not have substantial anticoagulant activity if the polyanion increases prothrombin time (PT), partial thromboplastin time (PTT), activated partial thromboplastin time (APTT), thrombin clotting time (TCT), or activated clotting time (ACT) by 0 to 10% of the normal range.