Patent ID: 9248144
Filing Date: 2016-02-02
CPC Classification: A61K,A61P,C12N,C12Q

Claim Text:
1. A method of treating heart failure and arterial obstructive disease in a subject comprising administering to the subject a composition comprising: a pharmaceutically acceptable carrier and at least one of: an agent that down regulates activity or expression of miR-142-5p in an amount sufficient to promote cardiac cell survival and enhance cardiac function in the subject, and an agent that upregulates miR-374 activity or expression in an amount sufficient to prevent myocyte hypertrophy in the subject, wherein the agent that downregulates activity or expression of miR-142-5p is an antisense molecule having complementarity to the precursor or mature sequence of miR-142-5p, and the agent that upregulates miR-374 activity or expression is a nucleic acid encoding a precursor or mature sequence of miR-374.