Patent ID: 9273315
Filing Date: 2016-03-01
CPC Classification: A61P,C12N

Claim Text:
1. A single-stranded modified oligonucleotide consisting of 20 linked nucleosides and having: a gap segment consisting of ten linked deoxynucleosides; a 5′ wing segment consisting of five linked nucleosides; and a 3′ wing segment consisting of five linked nucleosides; wherein the gap segment is positioned between the 5′ wing segment and the 3′ wing segment; wherein each nucleoside of each wing segment comprises a 2′O-methoxyethyl sugar; wherein the internucleoside linkages within the gap segment, the linkages connecting the gap segment to the 5′ and 3′ wing segments, and the linkages for the 5′-most and 3′-most nucleosides of each wing segment are all phosphorothioate linkages; and the internucleoside linkages connecting the rest of the nucleosides of both the 5′ and 3′ wing segments are phosphodiester linkages; and wherein the nucleobase sequence of the oligonucleotide consists of the sequence recited in SEQ ID NO: 22, or a pharmaceutically acceptable salt thereof.