Patent ID: 9453064
Filing Date: 2016-09-27
CPC Classification: A61K,A61P,C07K

Claim Text:
1. A GLP-2 analogue represented by the general Formula I: or a pharmaceutically acceptable salt thereof, wherein: R X2 is Gly, Ala or Aib; X3 is Glu, Gln or Asp; X5 is Ser or Thr; X7 is Ser or Thr; X8 is Asp, Glu or Ser; X9 is Glu or Asp; X10 is Met, Val, Leu or Tyr; X11 is Asn, Ser or Ala; X12 is Thr, Ser or Lys; X13 is Ile, Leu, Val, Tyr, Phe or Gln; X14 is Leu or Met; X15 is Asp or Glu; X16 is Asn, Gln, Gly, Ser, Ala, Glu or Lys; X17 is Gln, Lys, Arg, His or Glu; X19 is Ala or Val; X20 is Arg, Lys or His; X21 is Asp, Glu or Leu; X24 is Asn, Ala, Glu or Lys; X27 is Ile, Leu, Val, Glu or Lys; X28 is Gln, Asn, Lys, Ser, Gly, Y1 or absent; X29 is Thr, Ala, Y1 or absent; X30 is Lys, Y1 or absent X31 is Ile, Pro, Y1 or absent; X32 is Thr, Y1 or absent; X33 is Asp, Asn, Y1 or absent; X34 is Y1 or absent; Y1 is Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser, or Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser; and R the GLP-2 analogue contains no more than one Y1; if any of X28 to X33 is Y1, those positions X29 to X34 downstream of that Y1 are absent; if any of X28 to X33 is absent, those positions X29 to X33 downstream of that position are also absent; and with the proviso that the GLP-2 analogue of Formula I is not