Patent ID: 9249413
Filing Date: 2016-02-02
CPC Classification: A61K,A61P,C12N

Claim Text:
1. A pharmaceutical composition for topical application in the form of either (i) a water-in-oil-in-water emulsion or (ii) a water-in-oil emulsion, each of said emulsions comprising a dispersed, discontinuous, internal aqeous phase, the composition comprising: (a) at least one lipophilic emulsifier selected from the group consisting of a sorbitan fatty acid ester and a glycerol derivative; (b) at least one consistency agent; (c) at least one synthetic oil, natural oil, wax, or saturated hydrocarbon selected from the group consisting of a paraffin and a polysiloxane; (d) at least one additive comprising a salt or an ionic liquid, wherein the cation component of the salt or of the ionic liquid comprises an element selected from the group consisting of Na, Mg, K, Li, Ca, Fe, Cu, Ag and a combination of these elements; and, (e) at least one antisense oligonucleotide held by the internal aqueous phase, wherein the at least one antisense oligonucleotide is a DNAzyme directed against the mRNA coding for GATA-3 protein, the DNAzyme selected from a group consisting of DNAzymes of SEQ ID NO 1 to SEQ ID NO 70.