Patent ID: 9340792
Filing Date: 2016-05-17
CPC Classification: A61K,A61P,C12N,C12R,C12Y

Claim Text:
1. A recombinant or isolated bacterium having been genetically modified to decrease the display of lipoteichoic acid (LTA) on the surface of said bacterium, wherein the genetic modification comprises deletion or substitution of at least one base pair such that the expression of at least one polynucleotide encoding a phosphoglycerol transferase is decreased, wherein said polynucleotide encoding a phosphoglycerol transferase comprises a nucleotide sequence having at least 85% sequence identity to the nucleic acid sequence as set forth in SEQ ID NO:1; and wherein decreasing the expression of the at least one polynucleotide encoding a phosphoglycerol transferase decreases the display of LTA on the surface of the bacterium.