Patent ID: 9526800
Filing Date: 2016-12-27
CPC Classification: A61K,A61P,C07K,C12N,G01N

Claim Text:
1. A method of delivering an active agent to a tumor for treating or developing treatments, comprising administering to a colon cancer subject having a tumor binding reagents each of which interact specifically with an extracellular matrix (ECM) protein of a set of proteins characteristic of an ECM protein signature, wherein the binding reagents are conjugated to active agents in an effective amount to deliver the active agents to the tumor, wherein the signature ECM proteins includes at least 3 of the proteins selected from an ECM protein signature defined as being characteristic of metastatic primary colon carcinoma (group 4) but not including MMP9, MMP2, SPARC and/or TGFβ1, colon carcinoma metastases (group 5) but not including SPP1, metastatic colon carcinoma (primary & secondary) (group 6) but not including CTSB and/or S100A8, or a signature whose expression is associated with colon cancer or metastatic colon cancer (group 7) but not including MMP9, MMP2, SPARC, TGFβ1, SPPI, LOXL2, CTSB and/or S100A8.