Patent ID: 9382322
Filing Date: 2016-07-05
CPC Classification: A61K,A61P,C07K

Claim Text:
1. A method of enhancing tissue repair and regeneration to treat emphysema comprising administering an antibody, or an antigen binding fragment thereof, which modulates function of beta 1 integrin to a subject in need thereof, wherein the antibody or an antigen binding fragment binds to a domain of beta 1 integrin comprising amino acid residues 82 to 87 comprising residues TAEKLK (SEQ ID NO: 1) of mature beta 1 integrin and wherein the functional modulation of beta 1 integrin results in (i) an inhibition of apoptotic pathway, (ii) an alteration in metalloproteinases, (iii) an increase in an anabolism of extracellular matrix and (iv) an increase in inactive-MMP9.