Patent ID: 9371448
Filing Date: 2016-06-21
CPC Classification: C07D,C09B,G01N

Claim Text:
1. A method of detecting a proton in a sample, the method comprising: contacting the sample with a proton sensor to form a mixture; exposing the mixture to radiation to obtain an irradiated mixture; monitoring the florescence emission of the irradiated mixture, the proton sensor comprising a compound with an imidazo[1,5-α]pyridinium ion core of the structure of formula (I): wherein R R R H, alkyl, alkoxy, alkenyl alkenyloxy, alkynyl, alkynoxy, amide, amidino, amine, aryl, arylalkyl, azido, azo, carbamate, carbamide, carbonyl, carboxamido, carboxy, cycloalkyl, cycloalkoxy, ether, thioether, halogen, haloalkyl, heteroaryl, heterocyclyl, hydrazine, imino, nitro, phosphate, sulfate, sulfonamide, sulfonyl, sulfide, or thiocarbonyl, and when R 3 is alkenyl, alkenoxy, alkynyl, alkynoxy, aryl, heteroaryl, heterocyclyl or cycloalkyl, R 3 optionally is substituted with at least one R 4 , each R X − is a counter ion, and n is an integer from 1 to 4, wherein at least one of R a) a heteroaryl comprising a heteroatom comprising at least one pair of electrons conjugated to the imidazo[1.5-α]pyridinium ion core, the heteroatom being selected from the group consisting of nitrogen, oxygen, sulfur, and phosphorus, b) an aryl comprising a substituent comprising a heteroatom comprising at least one pair or electrons conjugated to the aryl, the heteroatom being selected from the group consisting of nitrogen, oxygen, sulfur, and phosphorous, or c) a combination of a) and b).