Patent ID: 9476050
Filing Date: 2016-10-25
CPC Classification: A61K,A61P,C12N

Claim Text:
1. A combination of at least one type of PME-1 silencing agent and a compound of Formula (I): wherein R′ is H or alkyl; R″ is H or alkoxy; R1 and R2 are H or together form oxo; R3 and R4 are independently H, OH or together form oxo: R5, R6, R6′, R7, and R8 are independently selected from the group consisting of H, alkyl, alkoxy, hydroxy, hydroxylalkyl, alkoxycarbonyl, or mono- and dialkylamino; X is CH n is 0 or 1, wherein the PME-1 silencing agent comprises a nucleic acid sequence selected from the group consisting of SEQ ID NOs: 1 to 39, for use as a medicament.