Patent ID: 9242934
Filing Date: 2016-01-26
CPC Classification: C07C,C07D

Claim Text:
1. A process for the preparation of compounds of formulae (7) and (8): in which R1=C1-C6 alkyl, substituted alkyl, aryl or substituted aryl, R2=H, C1-C6 alkyl or substituted alkyl; R4=F, Cl, Br, I, CF where X=OR1, SR1, NR2R2′, where R2′ is defined like R2 above and may be identical to or different from R2, n=1-4, R5=H, C1-C6 alkyl or substituted alkyl; R6=C1-C6 alkyl or substituted alkyl or OH; where compounds of formula (4): with the aforementioned definitions of the radicals R1, R2, R4, n and R5 and where R3 is an electron-withdrawing or activating group are prepared by a process comprises reacting a mixture of an aniline (compound of formula Q): in which the radicals R4, n and R5 are as defined in formula (4), with a thioether (compound of formula W): in which the radicals R1, R2 and R3 are as defined in formula (4), in the presence of a chlorinating agent and an organic solvent at a reaction temperature in the range between −60 and −10° C.; wherein the addition of an additional tertiary amine is dispensed with to give the compound of formula (4) and wherein the prepared compounds of formula (4) are reacted without isolation of the compounds of formula (4), optionally in the presence of an acid catalyst, to give the indole of formula (7) or the oxindole of formula (8).