Patent ID: 9329245
Filing Date: 2016-05-03
CPC Classification: G01R

Claim Text:
1. A method of producing hyperpolarized sample material that is utilized with magnetic resonance investigations, the method comprising the steps of: a) disposing a target material within a sample container, the target material containing high γ nuclei having a gyromagnetic ratio γ b) placing the sample container with the target material in a magnet, thereby exposing the target material to a static magnetic field B c) placing and keeping the sample container within a cryostat having liquid or gaseous helium, thereby maintaining the target material at a cryogenic temperature Tcr such that the target material is solid before performing step d); d) irradiating the polarizing agent in the solid target material with microwave radiation generated by a microwave source, thereby polarizing the high γ nuclei by DNP, wherein an EPR line of the polarizing agent has a width w e) subjecting the solid target material to RF radiation generated by at least one RF coil with two Larmor frequencies, thereby transferring polarization from the high γ nuclei to the low γ nuclei by Cross Polarization, wherein the solid target material is thereby disposed within the at least one RF coil; and f) dissolving the solid target material with a dissolution device having solvents, thereby preparing a dissolved sample material from the solid target material, wherein the sample material contains hyperpolarized low γ nuclei.