Patent ID: 9498541
Filing Date: 2016-11-22
CPC Classification: A61K,A61P,C07D,C07K,Y02A

Claim Text:
1. A method of treating a cancer comprising administering to a subject in need of treatment a therapeutically effective amount of a cell-binding agent-drug conjugate of formula (II) wherein: CB represents a cell-binding agent; D represents the drug linked to the cell-binding agent by a disulfide, thioether, thioester, peptide, hydrazone, ester, ether, carbamate, or amide bond; R R l, m and n are 0 or an integer from 1 to 4; Z is absent or a polyethyleneoxy unit of formula (OCH Y represents a carbonyl, thioether, amide, disulfide, or hydrazone group; and q represents an integer from 1 to 20.