Patent ID: 9496124
Filing Date: 2016-11-15
CPC Classification: G01N,H01J

Claim Text:
1. A method of imaging a biological sample comprising a plurality of cells, the method comprising steps of: (i) labelling at least one of a plurality of different target molecules in the biological sample with at least one of a plurality of different lanthanide labelling atoms, wherein each different labelling atom is attached to a different specific labelling construct, to provide a labelled biological sample; (ii) subjecting multiple cells of the labelled biological sample to laser ablation with a resolution at a cellular level or better at multiple known locations, to form a plurality of plumes; and (iii) subjecting plumes to inductively coupled plasma mass spectrometry; (iv) detecting the at least one labelling atoms in the plumes at the multiple known locations; and (v) constructing a cellular or subcellular level resolution image of the biological sample based the detection of the at least one labelling atoms in the plumes.