Patent ID: 9403892
Filing Date: 2016-08-02
CPC Classification: A61K,A61P,C07K,C12N,C12P

Claim Text:
1. A chimeric protein comprising from N-terminal to C-terminal direction: a human leucine zipper domain; a crosslinking region; and a full length human tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) domain, human TRAIL extracellular domain, or a fragment thereof, wherein the crosslinking region consists of CC or GS, the full length human TRAIL domain comprises the amino acid sequence according to SEQ ID NO:6, the human TRAIL extracellular domain comprises the amino acid sequence according to SEQ ID NO:7, and the fragment of the human TRAIL extracellular domain comprises the amino acid sequence according to SEQ ID NO:2.