Patent ID: 9428736
Filing Date: 2016-08-30
CPC Classification: A61K,A61P,C07K,C12N

Claim Text:
1. A vesicular stomatitis virus comprising an RNA molecule, wherein said RNA molecule comprises, in a 3′ to 5′ direction, a nucleic acid sequence that is a template for a positive sense transcript encoding a VSV N polypeptide, a nucleic acid sequence that is a template for a positive sense transcript encoding a VSV P polypeptide, a nucleic acid sequence that is a template for a positive sense transcript encoding a VSV M polypeptide, a nucleic acid sequence that is a template for a positive sense transcript encoding an interferon (IFN) polypeptide, a nucleic acid sequence that is a template for a positive sense transcript encoding a VSV G polypeptide, a nucleic acid sequence that is a template for a positive sense transcript encoding a Sodium Iodide Symporter (NIS) polypeptide, and a nucleic acid sequence that is a template for a positive sense transcript encoding a VSV L polypeptide, wherein said positive sense transcript encoding said IFN polypeptide comprises CUAACAG followed by a sequence encoding said IFN polypeptide followed by UAUGAAAAAAA (RNA of SEQ ID NO:1), and wherein said positive sense transcript encoding said NIS polypeptide comprises CUAACAG followed by a sequence encoding said NIS polypeptide followed by UAUGAAAAAAA (RNA of SEQ ID NO:1).