Patent ID: 9359601
Filing Date: 2016-06-07
CPC Classification: C07H,C12N,C40B

Claim Text:
1. A method of tagging DNA-encoded chemical libraries, said method comprising: (a) binding a first functional group of a bifunctional linker to a component of said chemical library, wherein said component comprises a functional moiety, (b) binding a second functional group of a bifunctional linker to an initiator oligonucleotide at the 5′ end of said initiator oligonucleotide, and (c) binding an identifier region at the 3′ end of said initiator oligonucleotide, wherein said initiator oligonucleotide is modified to increase solubility of a member of said DNA-encoded chemical library in organic conditions, wherein said modified initiator oligonucleotide comprises a nucleotide having a hydrophobic moiety, and said hydrophobic moiety is an aliphatic chain at the C5 position.