Patent ID: 9492418
Filing Date: 2016-11-15
CPC Classification: A61K,A61P

Claim Text:
1. A method of inhibiting an isozyme of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB) in a mammal; wherein the mammal has a cancer in which a PFKFB isozyme is overexpressed; said method comprising administering to the mammal an effective amount of a compound having the formula: wherein: X3 is —OH, and X4 is —OH; Y is —S— or R1 and R2 are independently selected from the group consisting of —H, and —CH R3 is —CH the configuration at the carbon-carbon double bond that is depicted in the formula between R1 and R2 is either E or Z.