Patent ID: 9457033
Filing Date: 2016-10-04
CPC Classification: A01N,A61K,A61L,A61P,C07J,G01N

Claim Text:
1. A method of preventing or treating an infection caused by a bacterial pathogen of the Firmicutes phylum in a subject, said method comprising administering to said subject a therapeutically effective amount of a compound or a composition comprising the compound and a pharmaceutically acceptable carrier, in combination with an aminoglycoside antibiotic, the compound being; (i) a compound of formula: wherein, (1) R1 is H, OH, NH (2) R2 is H, OH, NH (3) R1 and R2 together form ═O or ═NR12; R3 is α-H, β-H, α-alkyl, β-alkyl, α-OH or β-OH, or is absent when the double bond is present either in C4=C5, or in C5=C6; - - - - - is an optional double bond; R4-R6 are identical or different and are H, alkyl, OH, OR18, NHR18 or N(R18)(R18′); R7 is H, α-OH or β-OH; R8 is α-H, α-OH or β-OH; X and Y are identical or different and are O, NR19, or CH R12 and R12′ are identical or different and are H, alkyl, aryl, COalkyl, COaryl, CO R14, R22 and R22′ are identical or different and are H, alkyl, aryl, COalkyl, CO R18 and R18′ are identical or different and are H, alkyl, aryl, COalkyl, COaryl, CONHalkyl, CONHaryl, SO R19 is H, alkyl, aryl, COH, COalkyl, COaryl, CO R20, R20′ and R20″ are identical or different and correspond to the side chain of any L- and D- amino acid; R21, R21′ and R21″ are identical or different and are H, alkyl, OH, Oalkyl, Oaryl, NHalkyl, NHaryl, N(alkyl) n, n′, n″ and n′ are identical or different and are 0-5; m, m′ and m″ are identical or different and are 1-5; and p, p′, p″ and p′″ are identical or different and are 1-2; or a salt, stereoisomer or any mixture of stereoisomers of the compound of formula 1.0, whereby said bacterial infection is prevented or treated.