Patent ID: 9376495
Filing Date: 2016-06-28
CPC Classification: A61P,C07K

Claim Text:
1. A polypeptide that comprises a portion of a deimmunized albumin-binding protein capable of binding to serum albumin; wherein said deimmunized albumin-binding protein portion is a variant of a wild-type albumin-binding domain (ABD) of a Streptococcal Protein G, said wild-type ABD having the amino acid sequence of SEQ ID NO: 304; wherein said variant ABD has an amino acid sequence that differs from that of SEQ ID NO: 304 in comprising: (A) a valine to alanine variation at position 31 of SEQ ID NO:304; a valine to alanine variation at position 34 of SEQ ID NO:304; or an aspartate to alanine variation at position 39 of SEQ ID NO:304; (B) a leucine to alanine variation at position 24 of SEQ ID NO:304; an isoleucine to alanine variation at, position 25 of SEQ ID NO:304; and a valine to alanine variation at position 25 of SEQ ID NO:304; or (C) an asparagine to aspartic acid variation at position 26 of SEQ ID NO:304; a threonine to serine substitution at position 30 of SEQ ID NO:304; and a valine to alanine variation at position 31 of SEQ ID NO:304; wherein said deimmunized albumin-binding protein portion extends the serum half-life of said polypeptide, relative to the serum half-life of said polypeptide if lacking said portion of said deimmunized albumin-binding protein.