Patent ID: 9446405
Filing Date: 2016-09-20
CPC Classification: B01L,G01N

Claim Text:
1. A microfluidic device for use in a system comprising an intravenous delivery apparatus in fluid communication with the microfluidic device for providing an injectable test solution containing a test analyte to the microfluidic device, one or more intravenous lines with one or more ports to deliver the injectable test solution to the microfluidic device for analysis, a pump or pressure source to circulate the injectable test solution from one or more intravenous lines, and a reference solution, a valve in each of the intravenous lines for regulating flow of the injectable solution, and one or more controllers for operating the valves, the microfluidic device comprising: one or more test channels, each having a lumen; one or more reference solution channels in fluid communication with the one or more test channels; one or more sample channels in fluid communication with the one or more test channels with each sample channel also in fluid communication with the injectable test solution; a detector coupled to a plurality of sensors that are at least partially exposed within the lumen of the one or more test channels, the detector measuring at least one property of the test analyte; one or more ionic reference solution reservoirs in fluid communication with the one or more reference solution channels; and a processor that generates a response profile for the test analyte from said at least one measurement of a property, compares the generated profile to a known response profile for a specified analyte, estimates a likelihood that the generated profile and known response profile match within an acceptable range and generates an error signal when the likelihood of a match falls outside the acceptable range; wherein the response profile is generated by applying voltage pulses as the stimulus to the test analyte at one or more locations along the test channels, and wherein measuring the response to the stimulus received by the detector comprises measuring current resulting from the voltage pulses.