Patent ID: 9457062
Filing Date: 2016-10-04
CPC Classification: A61K,A61P,C07K

Claim Text:
1. A method for modulating Toll-like receptor signaling in a subject, or in at least one cell, tissue or organ thereof, wherein said method consists of administering to the subject an effective amount of human chaperonin 10 selected from the group consisting of SEQ ID NO: 1, SEQ ID NO: 2, and SEQ ID NO:3, wherein Toll-like receptor signaling involves association of the chaperonin 10 with a Toll-like receptor and a Toll-like receptor agonist in an activation cluster, and wherein the Toll-like receptor signaling involves at least one Toll-like receptor agonist present in the subject, or in at least one cell, tissue, or organ thereof, wherein the activation cluster comprises chaperonin 10, TLR2 and lipoteichoic acid (LTA).