Patent ID: 9487563
Filing Date: 2016-11-08
CPC Classification: A61K,C07K,C12N

Claim Text:
1. An alphavirus virus-like particle (VLP) comprising at least one altered viral protein selected from the group consisting of: a. an alphavirus E2 protein comprising one or more alterations, relative to the wild-type amino acid sequence, at one or more amino acid locations corresponding to one or more amino acid locations selected from the group consisting of H170, K200, K233, K234, R251 and H256 of CHKV E2 protein; and b. an alphavirus capsid protein comprising one or more alterations, relative to the wild-type amino acid sequence, at a charged amino acid residue in the Nuclear Localization Signal (NLS); wherein the at least one altered viral protein is capable of self-assembling into a VLP; and wherein the one or more alterations enhance VLP production.