Patent ID: 9315475
Filing Date: 2016-04-19
CPC Classification: A61K,A61P,C07D,C07F

Claim Text:
1. A compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein: V is CH Y each X is independently selected from H and NR Z is selected from the group consisting of L is a linker selected from wherein ** shows the point of attachment to the morpholine and when Z is  then L is not a bond; R is selected from H, halo, hydroxy, C each k is independently 0, 1 or 2; each r and t are independently 1, 2, 3 or 4; Z wherein said C each R or Z each R  wherein the asterisk (*) denotes the point of attachment to the rest of the compound and U each R alternatively, R each X T is O, S, S(O), or SO m is an integer equal to 0, 1, 2, or 3; n is an integer equal to 0, 1, 2, or 3; R R R each AryA is an aryl which is independently phenyl or naphthyl, wherein the phenyl or naphthyl is optionally substituted with from 1 to 3 Y each HetA is a heteroaryl which is independently (i) a 5- or 6-membered monocyclic heteroaromatic ring containing from 1 to 3 heteroatoms independently selected from N, O and S, or (ii) is a 9-, 10- or 11-membered bicyclic heteroaromatic ring containing from 1 to 4 heteroatoms independently selected from N, O and S; wherein the monocylcic ring (i) or the bicyclic ring (ii) is optionally substituted with from 1 to 3 Y each HetB is independently a 4- to 7-membered, saturated or unsaturated, non-aromatic heterocyclic ring containing at least one carbon atom and from 1 to 4 heteroatoms independently selected from N, O and S, where each S is optionally oxidized to S(O) or S(O)