Patent ID: 9492526
Filing Date: 2016-11-15
CPC Classification: A61K,A61P,C07K,C12N

Claim Text:
1. An isolated polynucleotide comprising at least one nucleotide sequence encoding at least two antigenic polypeptides, wherein said at least two antigenic polypeptides: (a) comprise (i) a first antigenic polypeptide comprising an amino acid sequence having at least 85% sequence identity over its length to the amino acid sequence of SEQ ID NO:2 and having a point mutation compared to SEQ ID NO:2 at each of L50, E148, T149, Q150, and L151; and (b) are capable of initiating an immune response to the oncogenic viral polypeptide in an immune-competent host; and (c) are non-oncogenic in the immune-competent host.