Patent ID: 9359648
Filing Date: 2016-06-07
CPC Classification: A61P,C07F,C12N,C12Q

Claim Text:
1. A method to distinguish between normal, pre-cancer or cancer cells comprising: a) contacting a sample comprising mammalian cells with two or more independently detectable compounds of 10 to 50 nucleobases in length complimentary to the antisense mitochondrial chimeric RNA of SEQ ID NO 4, SEQ ID NO 5, or SEQ ID NO 6 and/or the sense mitochondrial chimeric RNA of SEQ ID NO 1, SEQ ID NO 2, or SEQ ID NO 3, such that at least one detectable compound hybridizes to the target mitochondrial chimeric RNA sequences; b) detecting, identifying or quantitating the hybridization of the detectable compounds to the target sequences; and c) correlating and comparing the results obtained to the pattern of differential expression of the sense and antisense mitochondrial chimeric RNA in normal, pre-cancer and cancer cells.