Patent ID: 9458246
Filing Date: 2016-10-04
CPC Classification: A61K,A61P,C07K

Claim Text:
1. A bispecific protein comprising: (a) a polypeptide comprising an amino acid sequence having the following formula: A-L1-P-L2-P, wherein A is an immunoglobulin heavy chain of an IgG antibody, L1 is a first linker that is absent or is 3 to 40 amino acids long, P is a BAFF-binding peptide that is 10 to 40 amino acids long, and L2 is a peptide linker that is absent or is 5 to 50 amino acids long, and (b) an immunoglobulin light chain, wherein the immunoglobulin heavy chain of (a) and the immunoglobulin light chain of (b) can form an IgG antibody that can bind human B7RP1, wherein the protein can inhibit BAFF-mediated proliferation of human B cells and wherein the protein can inhibit B7RP1-mediated proliferation of human T cells.