Patent ID: 9309288
Filing Date: 2016-04-12
CPC Classification: A61K,A61P,C07K

Claim Text:
1. An antagonist compound of α v β 3 integrin, displaying a selective affinit for α v β 3 integrin, containing a cyclic RGD motif and two echistatin C-terminal moieties covalently linked by a spacer sequence having the following formula (I): wherein: AA1 is an alpha amino acid selected in the group of Cys, Asp, Glu, Lys, Orn, Pen, Dab or Dap; AA2 is an alpha amino acid selected in the group of Cys, Asp, Glu, Lys, Orn, Pen, Dab or Dap; L is a linker sequence consisting of a number of amino acid residues comprised between 0 and 2, such as the sequence PG; (Xaa)n is an amino acid sequence in which n ranges from 1 to 3, which sequence is substantially homologue to that of sequence 28-30 of Echistatin: MDD (Yaa)m is an amino acid sequence in which m ranges from 2 to 9, which sequence is substantially homologue to that of C-terminus (41-49) of Echistatin: RNPHKGPAT(SEQ ID NO:3).