Patent ID: 9333254
Filing Date: 2016-05-10
CPC Classification: A01K,A61K,A61P

Claim Text:
1. A method for treating an individual in need thereof comprising administering to the individual multiple administrations of an effective amount of an ISS wherein the ISS is administered at least 5 times and wherein the administration results in a long term disease modification of allergic rhinitis, wherein the long term disease modification is determined by the reduction of one or more allergic rhinitis symptoms for a period of at least 3 weeks after the last administration of the ISS, wherein the ISS is administered to the individual from about 3 days to about 4 weeks in between the dosages, and wherein the ISS comprises 5′-N x (TCG(N q )) y N w (X 1 X 2 CGX 2 ′X 1 ′(CG) p ) z (SEQ ID NO:14) wherein N are nucleosides with x =0-3, y =1-4, w =−2, −1, 0, 1 or 2, p=0 or 1, q =0, 1 or 2, and z =1-20, wherein X 1 and X 1 ′,X 2 and X 2 ′ are self-complimentary, and wherein the 5′ T of the (TCG(N g )) y (SEQ ID NO:3) sequence is 0-3 bases from the 5′ end of the polynucleotide.