Patent ID: 9447456
Filing Date: 2016-09-20
CPC Classification: C12Q,G01N

Claim Text:
1. A method of quantifying a target material in solution comprising: providing a plurality of nucleic acid fragments in a solution; exposing the solution comprising the plurality of nucleic acid fragments to a plurality of oligonucleotide tags such that at least one of the nucleic acid fragments may hybridize with at least one of the oligonucleotide tags; measuring the size of particles in the solution, including measuring at least one of the size of the plurality of nucleic acid fragments or the hybridized nucleic acid fragments and oligonucleotide tags, after a sufficient time for hybridization; determining a size distribution of the measured size of particles in the solution; and at least one of detecting or quantifying nucleic acid material by comparing the determined size distribution of the measured size of the particles in solution to a standard distribution of non-hybridized nucleic acid fragments to determine whether at least a subset of the nucleic acid fragments have hybridized with the oligonucleotide tags wherein no bead(s) is/are used in the quantification of said target material.