Patent ID: 9226925
Filing Date: 2016-01-05
CPC Classification: A61K,A61P

Claim Text:
1. A pharmaceutical composition comprising: a first drug substance consisting essentially of a first pharmaceutically acceptable organic acid addition salt of a first amine containing pharmaceutically active compound; and a second drug substance consisting essentially of a mixed salt of A-B-C wherein A and C are ionically bonded to B wherein A is a second amine containing pharmaceutically active compound selected from the group consisting of: peyote, amphetamine, mebutamate, phentermine, acetaminophen, bufotenine, diethyltryptamine, ibogaine, lysergic acid diethylamide, 3,4-methylenedioxyamphetamine, 3,4-methylenedioxymethamphetamine, psilocybin, psilocin, glutethimide, methamphetamine, methylphenidate, benzphetamine, ketamine, chlorodiazepoxide, clorazepate, fenfluramine, pemoline, thebenine, caffeine, acetorphine, acetylmethadol, allylprodine, alphacetylmethadol, dextromoramide, etorphine, heroin, ketobemidone, mescaline, methaqualone, N-ethyl-1-phenylcyclohexylamine, 1-(1-phenylcyclohexyl)pyrrolidine, 1-{1-(2-thienyl)-cyclohexyl}-piperidine, alphaprodine, anileridine, cocaine, dextropropoxyphene, diphenoxylate, ethylmorphine, hydrocodone, hydromorphone, levo-alpha-acetylmethadol, levorphanol, meperidine, methadone, morphine, oxycodone, oxymorphone, thebaine, phencyclidine, codeine, alprazolam, diethylpropion, flurazepam, halazepam, lorazepam, mazindol, midazolam, oxazepam, pentazocine, prazepam, quazepam, temazepam, triazolam, zolpidem, buprenorphine, imipramine, apomorphine, dihydrocodeine, codeinone, morphothebaine, metathebainone, phenyldihydrothebaine, thebainhydroquinone, flavothebanone, alpha-codeimethine, 14-hydroxycodeinone, sinomenine, hasubanonine, nalbuphine, nalmefene, naloxone, naltrexone, noscapine and oripavine, methylmorphenol and dihydrosinomenine, C is an amine selected from the group consisting of: methyl amine; ethyl amine; propyl amine; butyl amine; pentyl amine; hexyl amine; octyl amine; nonyl amine; decyl amine; undecyl amine; octadecyl amine; hexadecyl amine; di-dodecyl amine; dimethyl amine, diethyl amine; dipropyl amine; dibutyl amine; dipentyl amine; dihexyl amine; dicyclohexyl amine; diheptyl amine; dioctyl amine; didecyl amine; dioctadecyl amine; didodecyl amine; cyclohexyl amine; 2,3-dimethyl-1-cyclohexylamine; piperidine; morpholine; pyrrolidine; aniline; anisidine; rosin amine, dehydroabietyl amine; dihydroabietyl amine; hydroabietyl amine; adamantyl amine; isonipecotamide; polyoxyalkylenemonoamine wherein each oxyalkylene independently comprise 1-5 carbons; polyoxyalkylenediamine wherein each oxyalkylene independently comprise 1-5 carbons; polyoxyalkylenetriamine wherein each oxyalkylene independently comprise 1-5 carbons; 3,3′-diamino-N-methyl-dipropylamine; polyethylene imine; ethylene diamine; hexamethylene diamine; cyclohexyldiamines; 1,3-pentadiamine; 1,12-dodecanediamine; 3-dimethylaminopropylamine; 4,7,10-trioxa-1,13-tridecanediamine; diethylene triamine; 3,3-diamino-N-methyldipropylamine; tris(2-aminoethyl)amine; tridecylamine; pentadecylamine; hexadecylamine; heptadecylamine; octadecylamine; monodecylamine; eicosylamine; heneicosylamine; docosylamine; tricosylamine; tetracosylamine; pentacosylamine; hexacosylamine; laurylamine; myristylamine; palmitylamine; stearoamine; arachidylamine; behenylamine; lignocerylamine; lauroleylamine; myristoleylamine; palmitoleyamine; gadoleylamine; erucylamine; ricinoleylamine; linoleylamine; linolenylamine; eleostearoamine; arachidonylamine; clupanodylamine; di-dodecylamine; di-tridecylamine; di-pentadecylamine; di-hexadecylamine; di-heptadecylamine; di-octadecylamine; di-monodecylamine; di-eicosylamine; di-heneicosaneamine; di-docosylamine; di-tricosylamine; di-tetracosylamine; di-pentacosylamine; di-hexacosylamine; di-laurylamine; di-myristylamine; di-palmitylamine; di-stearoamine; di-arachidylamine; di-behenylamine; di-lignocerylamine; di-lauroleylamine; di-myristoleylamine; di-palmitoleyamine; di-gadoleylamine; di-erucylamine; di-ricinoleylamine; di-linoleylamine; di-linolenylamine; di-eleostearoamine; di-arachidonylamine; and di-clupanodylamine; tri-methyl amine, tri-ethyl amine, tri-proply amine, tri-butyl amine, tri-pentyl amine, tri-hexyl amine, tri-heptyl amine, tri-dodecylamine; tri-tridecylamine; tri-pentadecylamine; tri-hexadecylamine; tri-heptadecylamine; tri-octadecylamine; tri-monodecylamine; tri-eicosylamine; tri-heneicosylamine; tri-docosylamine; tri-tricosylamine; tri-tetracosylamine; tri-pentacosylamine; tri-hexacosylamine; tri-laurylamine; tri-myristylamine; tri-palmitylamine; tri-stearylamine; tri-arachidylamine; tri-behenylamine; tri-lignocerylamine; tri-lauroleylamine; tri-myristoleylamine; tri-palmitoleyamine; tri-gadoleylamine; tri-erucylamine; tri-ricinoleylamine; tri-linoleylamine; tri-linolenylamine; tri-eleostearylamine; tri-arachidonylamine; tri-clupanodylamine; meglumine and amino-glucose or said amine is defined by the formula: wherein at least one of R 23 , R 24 or R 25 is not hydrogen and R 23 , R 24 and R 25 are independently selected hydrogen, alkyl of 1-60 carbons; cyclic alkyl of 3-60 carbons; polyoxyalkylene with 1-5 carbons per oxyalkylene monomeric unit or polyoxyarylene with 8-60 carbons per oxyarylene monomeric unit; and B is wherein Y R G G R R R