Patent ID: 9360471
Filing Date: 2016-06-07
CPC Classification: A61K,A61P,A61Q,C12Q,G01N,Y02A

Claim Text:
1. A method of identifying or detecting an agent as a drug candidate for preventing or treating an age-related disease or disorder, the method comprising screening one or more compounds or compositions for their anti-aging activity using a mutant yeast comprising a dysfunctional telomere as senescence model system, said screening comprising the steps of: (i) incubating said one or more compounds or compositions with yeast cells for a period of time under conditions where a cell cycle is arrested by telomere dysfunction; (ii) removing the conditions under which the cell cycle is arrested and measuring the number of survived yeast cells; and (iii) comparing the number of survived yeast cells obtained in step (ii) with the number of survived yeast cells obtained in a control experiment under the same conditions as in step (i) but in the absence of said one or more compounds or compositions, whereby the ability to increase the number of survived yeast cells obtained in step (ii), as compared with the corresponding control experiment, would indicate that the tested compound or composition is capable of maintaining or extending G0 phase in a cell of the senescence model system and possesses anti-aging activity, and such tested compound or composition would be a useful agent as a drug candidate for preventing or treating an age-related disease or disorder.