Patent ID: 9364486
Filing Date: 2016-06-14
CPC Classification: A61K,A61P

Claim Text:
1. A method of treating demyelination and/or enhancing remyelination of an axon of a nerve cell that is need of remyelination comprising contacting one or more progenitor cells with an effective amount of a 6-substituted estradiol derivative of the formula: initiating transcription of RNA encoding genes involved in signaling pathways for differentiation of the one or more progenitor cells to one or more cells that form myelin; differentiating the one or more progenitor cells to the one or more cells that form myelin; and enhancing remyelination of the axon of the nerve cell from the one or more cells that form myelin, wherein the “a” ring is selected from the group consisting of R R X is selected from the group consisting of C Y is selected from the group consisting of H, ═O, —OCO(C Z is selected from the group consisting of H and methyl; m is an integer between 0-20; n is an integer between 0-8; each the