Patent ID: 9244070
Filing Date: 2016-01-26
CPC Classification: C07K,C12N,C40B,G01N

Claim Text:
1. A method for isolating a genetic package comprising a DNA encoding a ligand-binding polypeptide comprising the steps of: a) obtaining a population of genetic packages comprising a plurality of nucleic acid sequences encoding distinct ligand-binding polypeptides and encoding a second polypeptide that binds non-covalently to such ligand-binding polypeptides, wherein individual packages of said population further comprise a ligand-binding polypeptide encoded by the nucleic acid sequence of that package in complex with the encoded second polypeptide that binds non-covalently to the ligand-binding polypeptide; b) contacting said population with a target ligand; and c) selecting at least one genetic package based on binding of a distinct ligand-binding polypeptide encoded by said nucleic acid sequence to the ligand.