Patent ID: 9404108
Filing Date: 2016-08-02
CPC Classification: A61K,A61P,C07F,C12N

Claim Text:
1. A microRNA inhibitor comprising two or more sequences complementary to a sequence of a microRNA to be the target of inhibition, wherein said two or more complementary sequences are linked via linker residue(s), wherein the linker residue is bonded to each terminal portion of said complementary sequences present at both termini of the microRNA inhibitor, and wherein the linker residue is selected from the group consisting of (a) an atomic group represented by the following chemical formula (G1): wherein Gly in the chemical formula (G1) is an atomic group represented by the following chemical formula (Gly): —HN—CH 2 —CO—, wherein the terminal carbonyl carbon in the chemical formula (Gly) is bonded to the N atom in the chemical formula (G1), and wherein the terminal nitrogen atom in the chemical formula (Gly) is bonded to the carbonyl carbon in the chemical formula (G1), (b) an atomic group represented by the following chemical formula (G2): wherein GlyGly in the chemical formula (G2) is an atomic group represented by the following chemical formula (GlyGly): —HN—CH 2 —CO—HN—CH 2 —CO—, wherein the terminal carbonyl carbon in the chemical formula (GlyGly) is bonded to the N atom in the chemical formula (G2), and wherein the terminal nitrogen atom in the chemical formula (GlyGly) is bonded to the carbonyl carbon in the chemical formula (G2), and (c) an atomic group represented by the following chemical formula (TPA): provided that when the linker residue is present at the terminal portion of the complementary sequence of the aforementioned microRNA present at the terminus, a terminal of the linker residue is H, a protecting group, or a phosphate-protecting group.