Patent ID: 9301996
Filing Date: 2016-04-05
CPC Classification: A61K,A61P,C12N,C12Y

Claim Text:
1. A method for degrading an antibiotic in a patient's gastrointestinal (GI) tract, comprising administering an effective amount of a beta-lactamase to the patient, wherein: the antibiotic is a beta-lactam antibiotic selected from a penicillin and a cephalosporin, the beta-lactamase comprises an amino acid sequence having at least 90% sequence identity with SEQ ID NO: 1 and an asparagine (N) or arginine (R) at a position corresponding to position the beta-lactamase hydrolyzes ceftriaxone substantially more efficiently than a beta-lactamase of SEQ ID NO: 1 that has an aspartic acid (D) at a position corresponding to position