Patent ID: 9322893
Filing Date: 2016-04-26
CPC Classification: G01N,G01R,Y10T

Claim Text:
1. A method of distinguishing between glutamine formed by cataplerosis and glutamine formed by proteolysis in a subject, the method comprising: assaying a bodily sample from the subject for deuterated and non-deuterated glutamine by conducting determining a proportion of deuterated glutamine to total glutamine in the bodily sample and a proportion of non-deuterated glutamine to total glutamine in the bodily sample; and distinguishing between glutamine formed by cataplerosis and glutamine formed by proteolysis, wherein the proportion of deuterated glutamine to total glutamine is indicative of a proportion of glutamine formed from cataplerosis to total glutamine in the bodily sample and further wherein the proportion of non-deuterated glutamine to total glutamine is indicative of a proportion of glutamine formed from proteolysis to total glutamine.