Patent ID: 9296992
Filing Date: 2016-03-29
CPC Classification: A61P,C12N,C12P,C12Y

Claim Text:
1. An engineered polynucleotide encoding an engineered polypeptide having ketoreductase activity, wherein said engineered polypeptide comprises an amino acid sequence at least 90% identical to SEQ ID NO: 2 and comprises one or more amino acid substitutions relative to SEQ ID NO: 2, wherein the substitutions are selected from the group consisting of: P2L; V28A; A34S; A47V; E50K; D81N; S90V; I91L; I91W; I91R; I91K; K94R; D112Y; G117D; S143R; V144T; G145A; R148H; A150G; F152L; N153G; N153V; N153H; T158S; G190A; S198N; I199M; I199L; I199N; M200I; A217T; I225V; P231F; A232V; E233Q; D244G; F260Y; and S26N.