Patent ID: 9409252
Filing Date: 2016-08-09
CPC Classification: B01L,B23B,B23H,B23K,C23C,C23F,G01N,H01J

Claim Text:
1. A microfluidic device for separating a sample by chromatography, the microfluidic device comprising: diffusion bonded metallic sheets, each metallic sheet having a substantially similar composition, the diffusion bonded metallic sheets joined to create a hermetically sealed interface between each adjacent metallic sheet without the introduction of a secondary material and to enclose a separation channel within the diffusion bonded metallic sheets accessible by at least one of an inlet or an outlet to the separation channel; wetted surfaces of the separation channel coated with an organic material at least one monolayer thick, a deposited layer of inorganic-oxide positioned between the wetted surfaces of the separation channel and the organic material, and the coated separation channel packed with micrometer-sized particles serving as a stationary phase in a chromatographic separation.