Patent ID: 9314469
Filing Date: 2016-04-19
CPC Classification: A61K,A61P

Claim Text:
1. A method of treating a cognitive impairment associated with corticosteroid treatment as a result of a condition in a human in need of such treatment, comprising administering to the human an effective amount of at least one compound of formula I wherein: A is a bridge selected from the following radicals: —(CH 2 ) m —, —CH═CH—, —(CH 2 ) p —O—, —(CH 2 ) p —S—, —(CH 2 ) p —SO 2 —, —(CH 2 ) p —NR 1 — and —SO2—NR 2 —, and wherein: m is an integer of from 1 to 3 inclusive; p is an integer selected from 1 and 2; R 1 is selected from the group consisting of hydrogen and C 1 -C 5 alkyl; and R 2 is C 1 -C 5 alkyl; X and Y are independently selected from the group consisting of hydrogen and halogen; R and R′ are independently selected from the group consisting of hydrogen and C 1 -C 5 alkyl; n is an integer from 1 to 12 inclusive; and * denotes an asymmetric carbon and the bond designated by {character pullout} indicates that the absolute conformation about the asymmetric carbon can be either (R) or (S) only when all four groups attached to the asymmetric carbon are nonequivalent, or a pharmaceutically acceptable salt thereof, and wherein said cognitive impairment is selected from the group consisting of a foggy feeling, a poor ability to concentrate, unclear thinking, being in a sedated state, and a rapidly developing mental fatigue.