Patent ID: 9341619
Filing Date: 2016-05-17
CPC Classification: A61K,G01N

Claim Text:
1. A method for confirming the diagnosis of a hyposialylation disorder in a subject, comprising permethylating glycans in a biological sample from the subject; performing mass spectrometry to measure monosialylated Thomsen-Friedenreich (ST) antigen and non-sialylated Thomsen-Friedenreich antigen (T) from the biological sample, wherein Thomsen-Friedenreich antigen is N-acetylgalactosamine (GalNAc) linked to galactose (Gal); and determining the ratio of T to ST; wherein a ratio of T to ST of about 0.06 or greater confirms the diagnosis of the hyposialylation disorder, wherein the hyposialylation disorder is GNE myopathy.