Patent ID: 9260396
Filing Date: 2016-02-16
CPC Classification: A01N,C07D

Claim Text:
1. A process comprising:  (a) halogenating and reducing 4-nitropyrazole with concentrated hydrochloric acid at a temperature between about 10° C. and about 20° C. with between about 1 and about 4 equivalents of triethylsilane and about 1 to 10 weight percent palladium on alumina to yield 3-chloro-1H-pyrazol-4-amine hydrochloride (1a)  (b) reacting (1a) with activated carbonyl thioether X  (c) heteroarylation of (3a) with a halopyridine in the presence of a copper salt, an amine, and a base to yield thioether (3b)  (d) alkylating a thioether (3b) with R wherein R wherein X