Patent ID: 9296825
Filing Date: 2016-03-29
CPC Classification: A61K,A61P,C07K

Claim Text:
1. A monoclonal antibody or a fragment thereof, selected from the group consisting of: 1) a monoclonal antibody or a fragment thereof, having a heavy chain variable region including three CDRs comprising the amino acid sequence of SEQ ID NO: 7, the amino acid sequence of SEQ ID NO: 8 and the amino acid sequence of SEQ ID NO: 9, and a light chain variable region including three CDRs comprising the amino acid sequence of SEQ ID NO: 11, the amino acid sequence of SEQ ID NO: 12 and the amino acid sequence of SEQ ID NO: 13; 2) a monoclonal antibody or a fragment thereof, having a heavy chain variable region including three CDRs comprising the amino acid sequence of SEQ ID NO: 19, the amino acid sequence of SEQ ID NO: 20 and the amino acid sequence of SEQ ID NO: 21, and a light chain variable region including three CDRs comprising the amino acid sequence of SEQ ID NO: 23, the amino acid sequence of SEQ ID NO: 24 and the amino acid sequence of SEQ ID NO: 25; 3) a monoclonal antibody or a fragment thereof, having a heavy chain variable region including three CDRs comprising the amino acid sequence of SEQ ID NO: 27, the amino acid sequence of SEQ ID NO: 28 and the amino acid sequence of SEQ ID NO: 29, and a light chain variable region including three CDRs comprising the amino acid sequence of SEQ ID NO: 31, the amino acid sequence of SEQ ID NO: 32 and the amino acid sequence of SEQ ID NO: 33; 4) a monoclonal antibody or a fragment thereof, having a heavy chain variable region including three CDRs comprising the amino acid sequence of SEQ ID NO: 35, the amino acid sequence of SEQ ID NO: 36 and the amino acid sequence of SEQ ID NO: 37, and a light chain variable region including three CDRs comprising the amino acid sequence of SEQ ID NO: 39, the amino acid sequence of SEQ ID NO: 40 and the amino acid sequence of SEQ ID NO: 41; 5) a monoclonal antibody or a fragment thereof, having a heavy chain variable region including three CDRs comprising the amino acid sequence of SEQ ID NO: 43, the amino acid sequence of SEQ ID NO: 44 and the amino acid sequence of SEQ ID NO: 45, and a light chain variable region including three CDRs comprising the amino acid sequence of SEQ ID NO: 47, the amino acid sequence of SEQ ID NO: 48 and the amino acid sequence of SEQ ID NO: 49; 6) a monoclonal antibody or a fragment thereof, having a heavy chain variable region including three CDRs comprising the amino acid sequence of SEQ ID NO: 51, the amino acid sequence of SEQ ID NO: 52 and the amino acid sequence of SEQ ID NO: 53, and a light chain variable region including three CDRs comprising the amino acid sequence of SEQ ID NO: 55, the amino acid sequence of SEQ ID NO: 56 and the amino acid sequence of SEQ ID NO: 57; and 7) a monoclonal antibody or a fragment thereof, having a heavy chain variable region including three CDRs comprising the amino acid sequence of SEQ ID NO: 59, the amino acid sequence of SEQ ID NO: 60 and the amino acid sequence of SEQ ID NO: 61, and a light chain variable region including three CDRs comprising the amino acid sequence of SEQ ID NO: 63, the amino acid sequence of SEQ ID NO: 64 and the amino acid sequence of SEQ ID NO: 65.