Patent ID: 9234168
Filing Date: 2016-01-12
CPC Classification: A61K,A61P,C12N,Y02A

Claim Text:
1. A method of producing a replication-deficient microorganism, the method comprising a) culturing, harvesting, and/or suspending a viable microorganism in an aqueous environment comprising a radiation-protective composition, the composition comprising divalent manganese, orthophosphate and the amino acids Aspartate, Glutamate, Histidine, Glycine, Threonine, Alanine, Valine, Methionine, Leucine, and Lysine, or a decapeptide thereof, b) irradiating the microorganism in the radiation-protective composition with a dose of ionizing radiation sufficient to render the microorganism replication-deficient.