Patent ID: 9254319
Filing Date: 2016-02-09
CPC Classification: A61K,A61P,C07K,C12N

Claim Text:
1. A vector comprising a insert encoding one or more antigens that elicit an immune response against an HIV of a subtype or recombinant form, said insert encoding for (a) a HIV-1 Gag protein in which both zinc fingers have been inactivated by amino acid changes corresponding to HIV Clade B HXB2 C392S, C395S, C413S and C416S; (b) a HIV-1 Pol protein in which (i) the integrase activity is inhibited by the deletion of integrase, (ii) the reverse transcriptase activity is inhibited by amino acid changes corresponding to HIV Clade B HXB2 D185N, W266T and E478Q, and (iii) the protease activity is inhibited by amino acid change corresponding to HIV Clade B HXB2D25A.