Patent ID: 9278131
Filing Date: 2016-03-08
CPC Classification: A61K,C07K

Claim Text:
1. A process of lowering the viscosity of an initial solution of at least one protein comprising at least one antibody fragment whose concentration is between 50 and 350 mg/mL and whose pH is between 5 and 8, comprising introducing to the initial solution a compound of formula I at a concentration in the final formulation of between 10 and 250 mM: in which: G is a C6 to C10 phenyl or alkylphenyl group, the phenyl group optionally being substituted with one or more hydroxyl groups, L is either a bond or a function chosen from the group consisting of the ether function, the carbamate function and the amide function, m and n are identical or different integers between 0 and 2 such that 0<m+n≦3, R R X the asymmetric carbon atoms have an R or S configuration, the compound having a solubility in water of ≧20 mM at a pH of between 5 and 8, wherein the process lowers the viscosity of the initial solution by a value of at least 15% relative to the viscosity of a solution of at least one protein comprising at least one antibody fragment of the same concentration and of the same pH not containing the compound.