Patent ID: 9328340
Filing Date: 2016-05-03
CPC Classification: A61K,A61P,C12N,C12Y

Claim Text:
1. A composition, comprising a pharmaceutically-acceptable carrier and an isolated histidyl-tRNA synthetase (HRS) polypeptide selected from (a) a polypeptide that comprises SEQ ID NO:28, (b) a fragment of (a) comprising at least 500 contiguous amino acids of SEQ ID NO:28, and (c) a variant of (a) having at least 95% identity to SEQ ID NO:28, where the HRS polypeptide is not significantly associated with in vivo substances, has an anti-inflammatory activity, reduces the migration of infiltration of immune cells, does not significantly increase the production of pro-inflammatory cytokines, and is at least about 90% pure, and where the composition is sterile and pyrogen-free.