Patent ID: 9428578
Filing Date: 2016-08-30
CPC Classification: A61K,C07K,C12Q

Claim Text:
1. A method of treating or reducing the risk of anaemia in a human haemodialysis patient, the method comprising administering a trap, an antibody or an antibody fragment that binds specifically to BMP6 to the human haemodialysis patient, wherein the trap, antibody or antibody fragment comprises a human kappa chain constant region comprising a Val at position 84 shown in SEQ ID NO: 93 or a Cys at position 87 shown in SEQ ID NO: 9; and wherein (i) the human comprises a TMPRSS6 nucleotide sequence comprising a SNP rs855791; rs2543519; rs2235324; or rs1421312; and (ii) the human comprises and expresses an IGKC1*01 human kappa chain constant region gene segment, or the human expresses antibodies comprising human kappa chain constant regions comprising a Val corresponding to position 84 shown in SEQ ID NO: 93 or a Cys at position 87 shown in SEQ ID NO: 93.