Patent ID: 9376397
Filing Date: 2016-06-28
CPC Classification: A61K,A61P,C07D,C07F

Claim Text:
1. A process for preparing rosuvastatin, comprising: (a) reacting a compound of formula IX or IX′ wherein P with a compound of formula X or X′ wherein Z is selected from the group consisting of: and wherein Rx, Ry, and Rz, are the same or different and are selected from optionally substituted C (b) obtaining reaction products of a compound of formula I and a compound selected from formulas XI or XI′ wherein P (c) separating the obtained reaction products into the compound of formula I and the compound selected from formulas XI or XI′; and (d) using the obtained compound selected from formulas XI or XI′ for conversion into rosuvastatin or pharmaceutically acceptable salts thereof, wherein the compound of formula I obtained in step (c) is used in a recycling process for producing rosuvastatin comprising: (e) converting the compound of formula I into the compound of formula II by bromination wherein said bromination is performed with an N-bromoamide as a brominating agent and optionally converting the compound of formula II into the compound of formula Ill by hydrolysis (f) converting the compound of formula II or III, respectively, to the compound of formula XI or XI′; and (g) subjecting the compounds of formula XI or XI′ obtained by converting the compounds of formula II or III, respectively, to further synthesis steps to yield rosuvastatin or pharmaceutically acceptable salts thereof.