Patent ID: 9427478
Filing Date: 2016-08-30
CPC Classification: A61K,A61P,C07K

Claim Text:
1. A composition comprising a plurality of antibodies or antibody fragments, wherein the plurality of antibodies or antibody fragments share the same heavy and/or light chain amino acid sequence, and wherein at least 90% of the antibodies or antibody fragments in said composition have (m) functionalized acceptor glutamine residues (Q) per antibody or fragment, wherein m is an integer selected from 2 or 4, and wherein each of the functionalized acceptor glutamine residues has the structure of Formula IVc, or a pharmaceutically acceptable salt or solvate thereof, wherein: Q is a glutamine residue present within or appended to a constant region of the antibodies or antibody fragments; C is a substituted alkyl chain, an unsubstituted alkyl chain, a substituted heteroalkyl chain, or an unsubstituted heteroalkyl chain; X is NH, O, S, absent, or a bond; L is independently absent, a bond or a continuation of a bond, or a carbon comprising framework of 1 to 200 atoms substituted at one or more atoms; (RR′) is an addition product between a reactive moiety R and a complementary reactive moiety R′; L′ is independently absent, a bond or a continuation of a bond, or a carbon comprising framework of 1 to 200 atoms substituted at one or more atoms; V is independently absent, a bond or a continuation of a bond, a non-cleavable moiety or a conditionally-cleavable moiety; Y is independently absent, a bond or a continuation of a bond, or a spacer system which is comprised of 1 or more spacers; and Z is a pyrrolobenzodiazepine, wherein the antibodies or antibody fragments specifically bind to a tumor antigen.