Patent ID: 9518284
Filing Date: 2016-12-13
CPC Classification: A61P,C12Q,G01N

Claim Text:
1. A method of screening for a compound that decreases toxicity associated with ataxin-1, ataxin-2, ataxin-3, ataxin-7, calcium channel, androgen receptor, atrophin-1, SOD1, immunoglobulin light chain, transthyretin, tau, serum amyloid A, islet amyloid polypeptide, insulin, beta2-microglobulin, cystatin-C, gelsolin, or lysozyme, the method comprising: providing a yeast cell engineered to express a protein comprising a ataxin-1, ataxin-2, ataxin-3, ataxin-7, calcium channel, androgen receptor, atrophin-1, SOD1, immunoglobulin light chain, transthyretin, tau, serum amyloid A, islet amyloid polypeptide, insulin, beta2-microglobulin, cystatin-C, gelsolin, or lysozyme polypeptide; contacting the yeast cell with a candidate compound; and evaluating the yeast cell for viability, wherein an increase in viability of the yeast cell as compared to viability of the yeast cell in the absence of the candidate compound indicates that the candidate compound decreases toxicity associated with ataxin-1, ataxin-2, ataxin-3, ataxin-7, calcium channel, androgen receptor, atrophin-1, SOD1, immunoglobulin light chain, transthyretin, tau, serum amyloid A, islet amyloid polypeptide, insulin, beta2-microglobulin, cystatin-C, gelsolin, or lysozyme.