Patent ID: 9243226
Filing Date: 2016-01-26
CPC Classification: A61K,C12N

Claim Text:
1. A method of modifying a mesenchymal stem cell to up-regulate expression of CRYAA, LAMA5, IVL, or ITBG1 in said mesenchymal stem cell, in vitro, said method comprising the steps of: introducing a Pax 6 or Klf4 gene sequence, or a combination thereof, into said mesenchymal stem cell to produce a modified mesenchymal stem cell; and growing said modified mesenchymal stem cell under conditions to allow expression of said gene sequence or combination thereof, wherein expression of said gene sequence up-regulates expression of CRYAA, LAMA5, IVL and ITBG1 in said modified mesenchymal stem cell, in vitro.