Patent ID: 9346864
Filing Date: 2016-05-24
CPC Classification: B01F,C07K

Claim Text:
1. A process for amplification of aggregated conformation prion protein from native conformation prion protein, comprising: contacting the native conformation prion protein with the aggregated conformation prion protein in a liquid to form a liquid composition; and subjecting the liquid composition to at least one cycle comprising the generation of shear force for fragmenting the aggregated conformation prion protein and a resting phase, wherein the shear force is applied to each volume element of the liquid composition and consists of a uniform shear-force intensity having a value within ±10% of a given shear-force value, wherein the shear-force is generated by rotation of a rotary element arranged within a spaced coaxial wall and passing each volume element between the rotary element and the wall while the rotation is controlled to within ±10% of one rate.