Patent ID: 9518976
Filing Date: 2016-12-13
CPC Classification: A61K,A61P,G01N

Claim Text:
1. A method for identifying an agent that reduces osteocalcin carboxylation comprising: (a) determining a first level of carboxylated osteocalcin in a first cell that expresses osteocalcin, (b) contacting a second cell that expresses osteocalcin with the agent and determining a second level of carboxylated osteocalcin in the second cell, and (c) comparing the first level of carboxylated osteocalcin with the second level of carboxylated osteocalcin, wherein the first cell and the second cell have been genetically engineered to overexpress osteocalcin, and wherein the agent is identified as an agent that reduces osteocalcin carboxylation if the first level of carboxylated osteocalcin is higher than the second level.