Patent ID: 9423406
Filing Date: 2016-08-23
CPC Classification: G01N

Claim Text:
1. A method for determining whether a subject not undergoing statin treatment who is not suffering from type 2 diabetes mellitus is at risk to develop one or more Cardiovascular Disease (CVD) complications, comprising: a) determining in a sample from said subject one or more lipid-lipid concentration ratio(s), wherein (an) increased lipid-lipid concentration ratio in said sample, when compared to a control sample is (are) indicative of said subject having an increased risk of developing one or more CVD complications, wherein the one or more lipid-lipid concentration ratio(s) whose increase(s) is (are) compared to the control is (are) selected from: Cer(d18:1/16:0)/Cer(d18:1/22:0) and Cer(d18:1/16:0)/Cer(d18:1/24:0); or b) determining in a sample from said subject one or more lipid-clinical concentration ratio(s), wherein (an) increased or decreased lipid-clinical concentration ratio(s) in said sample, when compared to a control sample is (are) indicative of said subject having an increased risk of developing one or more CVD complications, wherein the one or more lipid-clinical concentration ratio(s) whose increase(s) is (are) compared to the control is selected from: Cer(d18:1/16:0)/HDL cholesterol and Cer(d18:1/16:0)/apoliprotein B; and wherein the one or more lipid-clinical concentration ratio(s) whose decrease(s) is (are) compared to the control is (are) selected from: Cer(d18:1/24:1)/supersensitive C-reactive protein and Cer(d18:1/22:0)/supersensitive C-reactive protein, and wherein said determining comprises determining at least two lipid-lipid concentration ratios or at least two lipid-clinical concentration ratios or a combination of at least one lipid-lipid concentration ratio and at least one lipid-clinical concentration ratio.