Patent ID: 9321994
Filing Date: 2016-04-26
CPC Classification: A61K,A61P,C12N

Claim Text:
1. An induction medium for creating an immunologically polarized mesenchymal stem cell population from an unstimulated mesenchymal stem cell population, the induction medium comprising: a. a Toll-like receptor 4 (TLR4) ligand, at a concentration from about 1 nanogram per milliliter to about 100 micrograms per milliliter, b. erythropoietin, and c. 0.5-2.0% oxygen or a hypoxia mimetic, wherein the induction media creates the immunologically polarized mesenchymal stem cell population upon exposure of the induction media to the unstimulated mesenchymal stem cell population; and wherein the immunologically polarized mesenchymal stem cell population possesses pro-inflammatory characteristics marked by expression of pro-inflammatory mediators.