Patent ID: 9527863
Filing Date: 2016-12-27
CPC Classification: A61K,A61P,C07D,C07K

Claim Text:
1. A compound of formula (II) wherein R1 and R2 taken together form a group (D) or (G): wherein R5 is hydrogen, linear or branched C R3 and R4 are, each independently, hydrogen or a group selected from an optionally substituted linear or branched C R6 is a leaving group; T is null or N; BM of formula (V): wherein: X is null, linear or branched C Y is an optionally substituted aryl or heteroaryl selected from the group consisting of Y′ is an optionally substituted aryl or heteroaryl selected from wherein R15, R16 and R20 are independently hydrogen, halogen, hydroxy, NO U is a moiety of formula (VI) or (VII): wherein R3 is as defined above; q is an integer from 0 to 4; L1 is hydrogen or L, wherein L is null or a moiety selected from NHCO—R9 (Xa); —NHCONH—R9 (Xb); —NHCOO—R9 (Xc); —NH—R9 (Xd); wherein R9 and R10 are, each independently, hydrogen, hydroxy or an optionally substituted group selected from linear or branched C R9 and R10 are null when at least one of W1 and Z1 is not null, n is an integer from 0 to 2 and n1 is an integer from 0 to 4; W1 is null or a system comprising one or more groups independently selected from wherein one of R9 and R10 is null and the other is as defined above, R11 and R12 are, each independently, hydrogen, halogen, methyl, ethyl or linear or branched C m is an integer from 0 to 3, and A Z1 is null or a peptidic linker (Z Z Z wherein one of R9 and R10 is null and the other is as defined above and p is an integer from 1 to 20; and Z wherein Z provided that a compound of formula (II) wherein L1 is hydrogen is excluded when 1) both T and X are null, q is 0 and Y′ is an heterocyclyl moiety of formula (VIII), (VIII)′ or (VIII)″: or 2) both T and X are null, q is 1, U is a group of formula (VII), Y is an heterocyclyl moiety of formula (IX) and Y′ is an heterocyclyl moiety of formula (VIII)′″ wherein Q is —NH— or O, and R21 is hydrogen or a group selected from —N(C with the proviso that in a compound of formula (II) when L1 is L, at least one among L, W1 and Z1 is not null; or the pharmaceutically acceptable salts thereof.