Patent ID: 9314448
Filing Date: 2016-04-19
CPC Classification: A61K,A61P,C07C,C07D

Claim Text:
1. A method of inhibiting ABCG2 in a mammal afflicted with cancer, wherein the cancer over-expresses ABCG2, which method comprises administering to the mammal an effective amount of a compound of formula (I) to inhibit ABCG2 protein: wherein R X X double bond “a” can be cis or trans and double bond “b” can be Z or E; with the proviso that the compound is not botryllamide C, wherein the method further comprises administering to the mammal an effective amount of a chemotherapeutic agent for treating tumor cells in the mammal, wherein the chemotherapeutic agent is selected from the group consisting of mitoxantrone, topotecan, irinotecan, flavopiridol, methotrexate, rhodamine, daunomycin, imatinib, doxorubicin, paclitaxel, docetaxel, and a combination thereof, and wherein the treatment of tumor cells in the mammal with the chemotherapeutic agent is enhanced.