Patent ID: 9528110
Filing Date: 2016-12-27
CPC Classification: A61K,A61P,C12N

Claim Text:
1. A synthetic, modified oligonucleotide of 15 to 30 nucleotides in length comprising at least one modification wherein the at least one modification is selected from: at least one modified sugar moiety; at least one modified intemucleotide linkage; at least one modified nucleotide, and combinations thereof; wherein said oligonucleotide is an antisense compound which specifically hybridizes and is at least 95% complementary to a natural antisense polynucleotide of an IQ motif containing GTPase activating protein (IQGAP) having sequence identity to SEQ ID NO: 2 and upregulates the function and/or expression of an ‘IQ motif containing GTPase activating protein’ (IQGAP) gene in vivo or in vitro as compared to a normal control.