Patent ID: 9284594
Filing Date: 2016-03-15
CPC Classification: C12Q,G01N

Claim Text:
1. A method for characterizing a biological sample, comprising: a) providing: b) digesting said biological sample with said one or more proteases resulting in generation of biological sample-based peptide fragments, c) combining said one or more distinct groups of labeled peptides with said generated biological sample-based peptide fragments, d) purifying said labeled peptides combined with said generated biological sample-based peptide fragments, e) conducting a multiple reaction monitoring mass-spectrometry (MRM-MS) analysis of said purified biological sample-based peptide fragments combined with said labeled peptides, and f) analyzing the results of said MRM-MS analysis, wherein said analyzing comprises detecting the presence or absence of a biological sample-based fusion protein peptide fragment having an amino acid sequence identical with the amino acid sequence for one of the distinct groups of labeled peptides specific for a particular fusion protein, wherein detected co-elution of indicates the presence of said particular fusion protein within said biological sample.