Patent ID: 9453053
Filing Date: 2016-09-27
CPC Classification: A61K,A61P,C07K

Claim Text:
1. A positive inotropic peptide comprising or consisting of a hydrophilic domain and a S100A1 protein derived domain, wherein said S100A1 protein derived domain consists of 4 to 9 consecutive amino acids of the inotropic motif: and comprises at least the core motif Φ 4 -X 5 -ψ 6 -L 7 , wherein Φ and ψ are in each instance independently selected from the group consisting of alanine, methionine, isoleucine, leucine, and valine, and X is any amino acid, wherein said peptide has a total length of minimally 10 amino acids and maximally 30 amino acids, and the peptide exhibits a positive inotropic action, and wherein said hydrophilic domain comprises or consists of the hydrophilic amino acid motif: Λ 4 -Θ 2 , wherein Λ is in each instance independently selected from aspartate, glutamate, lysine, and arginine and Θ is an α-helix interrupter is in each instance independently selected from proline or glycine.