Patent ID: 9447052
Filing Date: 2016-09-20
CPC Classification: A61P,C07C,C07D

Claim Text:
1. A process for making a compound of formula (I): wherein: R R R R R R R the process comprising: (a) treating a C (b) cyclising a compound of said formula (A) to form the hexahydro-1H-cyclopenta[d]pyrimidin-1-yl)acetic acid of formula (B) by treating a compound of said formula (A) with either: (i) a thiocyanate salt and a) a haloalkylsilane and a proton source, with heating, or b) an anhydrous acid, with heating; or (ii) trimethylsilylisothiocyanate, with heating; (c) forming a thio-4-oxo-4,5,6,7-tetrahydro-1H-cyclopenta [d]pyrimidin-1-yl)acetic acid of formula (C) where n is 0 to 3, by treating a compound of said formula (B) with a thio-alkylating reagent which is a benzyl derivative of formula (D) where n is 0 to 3 and X is a leaving group, in the presence of an alkali metal base and/or an alkali metal carbonate; and (d) forming a compound of formula (I) by treating a compound of said formula (C) with carbonyldiimidazole and the secondary amine of formula (F) and heating the mixture.