Patent ID: 9526698
Filing Date: 2016-12-27
CPC Classification: A61K,A61M,A61P

Claim Text:
1. A method to administer a combination of antibiotics during mechanical ventilation of a patient to alleviate ventilator associated pneumonia (VAP) or ventilator associated tracheal bronchitis (VAT) comprising: establishing a positive pressure in the airway of a mechanical ventilator to provide assisted breathing to the patient, wherein the mechanical ventilator has means for introducing humidified air to the airway; connecting an inline nebulizer having an outlet into the airway, activating the nebulizer such that the nebulizer introduces an aerosol mist in the airway, wherein the mist is created from a solution stored in a reservoir therein wherein the aerosol mist formed in the nebulizer is comprised of a distribution of particles having a mean particle size less than 5 microns, wherein the solution is a combination of a bactericidal combination of amikacin and fosfomycin at a ratio of amikacin to fosfomycin greater than 1.0:1.0 and in a hypertonic solution having at least 30 mEq/L permeant ion and an osmolality less than 1000 mOsmoi/L; combining the aerosol mist with the humidified air such that a mean particle size of the aerosol mist increases by at least 10% and the osmolality decreases by at least 25%; and maintaining activation of the nebulizer until a dosage of amikacin and fosfomycin is delivered to achieve a MIC 90 for an organism selected from a Gram-positive organism and a Gram-negative organism and combinations thereof.