Patent ID: 9272038
Filing Date: 2016-03-01
CPC Classification: A61K,A61L,A61P

Claim Text:
1. A gel formulation for use in filling a wound cavity and delivering an active ingredient thereto, having a pH range of 6.5 to 7.5, low bioadhesive strength and cohesive integrity and being formed from poly(vinyl) alcohol (PVA) polymer, a cross-linker being a salt form of boron that produces borate ions in aqueous solution, at least one compound which has a beneficial effect as an active ingredient in the wound and at least one modulator, the modulator being a low molecular weight species that is capable of binding borate or PVA in aqueous solution through a mono-diol or di-diol formation and reduces the pH of PVA-borate hydrogels; wherein the modulator includes at least one compound chosen from the group consisting of mannitol, maltitol, dulcitol, D-sorbitol, xylitol, and meso-erythritol, and the amount of modulator is from 0.1 to 5.0% by weight based on the total weight of the formulation; and wherein the active ingredient is lidocaine hydrochloride and wherein the amount of lidocaine hydrochloride is 3% w/w or greater based on the total weight of the formulation.