Patent ID: 9499613
Filing Date: 2016-11-22
CPC Classification: A61K,A61N,A61P,C07H,C07K,C12N

Claim Text:
1. A method of inhibiting activity of Notch1 in a cell, comprising contacting the cell with an effective amount of an antibody that specifically binds human Notch1, wherein the antibody comprises: (a) a heavy chain CDR1 comprising RGYWIE (SEQ ID NO:15); a heavy chain CDR2 comprising QILPGTGRTNYNEKFKG (SEQ ID NO:16); and a heavy chain CDR3 comprising FDGNYGYYAMDY (SEQ ID NO:17); and (b) a light chain CDR1 comprising RSSTGAVTTSNYAN (SEQ ID NO:18); a light chain CDR2 comprising GTNNRAP (SEQ ID NO:19); and a light chain CDR3 comprising ALWYSNHWVFGGGTKL (SEQ ID NO:20).