Patent ID: 9340617
Filing Date: 2016-05-17
CPC Classification: A61K,A61P,C07K,C12N,G01N

Claim Text:
1. A chimeric fusion protein comprising a targeting moiety to target a cancer cell and an immunomodulating moiety that counteracts immune tolerance, wherein the targeting moiety and the immunomodulating moiety are linked by an amino acid spacer selected from SEQ ID NO: 3 or SEQ ID NO: 11, wherein the immunomodulating moiety is TGF-βRII SEQ ID NO: 4, wherein the targeting moiety is Anti-HER2/neu having heavy chain SEQ ID NO: 1 and light chain SEQ ID NO: 2; wherein SEQ ID NO: 4 is attached via the amino acid spacer to the C-terminus of SEQ ID NO: 1 or SEQ ID NO: 2.