Patent ID: 9352025
Filing Date: 2016-05-31
CPC Classification: A61K

Claim Text:
1. A method of treating a metabolic disorder or key elements of a metabolic disorder such method comprising the step of administering to a patient having a metabolic disorder or a patient in need thereof, (a) a dopamine receptor agonist; and (b) a first-phase insulin secretagogue selected from the group consisting of glucagon like peptide-1 (GLP-1) or an analog thereof, a dipeptidyl peptidase inhibitor, gastric inhibitory polypeptide (also known as glucose-dependent insulinotropic peptide), a meglitinide, repaglinide, nataglinide and short acting insulin, wherein the dosage of each of said dopamine receptor agonist and first-phase insulin secretagogue in combination, provides a therapeutic effect greater than the additive effect of administering the same dosage of each of said dopamine receptor agonist and first-phase insulin secretagogue alone and wherein the dopamine receptor agonist is administered so as to increase central dopaminergic activity at the time of day its circadian rhythm naturally peaks in healthy subjects of the same species and said first phase insulin secretagogue is administered such that an effective amount is present daily.