Patent ID: 9353109
Filing Date: 2016-05-31
CPC Classification: A61P,C07D

Claim Text:
1. A method for chemically synthesizing an analog of dimethylisoborreverine, comprising the steps of: adding an alkylating agent to tryptamine derivatized independently at one or more of C4, C5, C6, and C7 with hydroxy, methoxy, acetoxy, benzyloxy, sulfomethyl, amino, acetate, methyl, ethyl, iso-propyl, t-butyl, trifluoromethyl, cyano, methylformate, nitrate, or halide; adding an acylating agent in the presence of a base to form a substituted piperidinyl-N-carbamate intermediate; adding a strong reducing agent to the intermediate to produce a borrerine derivative; methylating the borrerine derivative with a methylating agent; dimerizing the methylated borrerine derivative in the presence of trifluoroacetic acid to yield the dimethylisoborreverine analog.