Patent ID: 9290577
Filing Date: 2016-03-22
CPC Classification: A61K,A61P,C07K

Claim Text:
1. An isolated protein comprising an immunoglobulin heavy chain variable region (V H ) and an immunoglobulin light chain variable region (V L ), wherein at least one of the variable regions comprises at least two cysteine residues substituted at positions exposed to solvent within a framework region 1 (FR1), wherein: (i) the at least two cysteine residues consist of 2, 4, or 6 cysteine residues, (ii) if at least two of the cysteine residues are not conjugated to a compound then a disulphide bond is capable of forming within the FR1 between the cysteine residues; and (iii) if the V L comprises the at least two cysteine residues, they are substituted at any of Kabat positions L7 to L19, and if the V H comprises the at least two cysteine residues, they are substituted at any of Kabat positions H7 to H20.