Patent ID: 9527901
Filing Date: 2016-12-27
CPC Classification: A61K,A61P,C07K

Claim Text:
1. A recombinant bi-functional fusion protein, comprising an Ig-like region of an extracellular domain of a signal-regulatory protein alpha (SIRPα), linked via a linker, to an Ig-like region of an extracellular domain of vascular endothelial growth factor (VEGF) Receptor (VEGFR), wherein the protein can bind to Cluster of Differentiation 47 (CD47) and YEW blocking the binding of CD47 to the SIRP on the cell surface of macrophages to stimulate the phagocytosis of tumor cells by macrophages, and inhibiting the growth of vascular endothelial cells induced by VEGF.