Patent ID: 9480756
Filing Date: 2016-11-01
CPC Classification: A61K,A61N,A61P,C07D,C07K,Y02A

Claim Text:
1. An immunoconjugate having a structural formula MAb-linker-SN-38, wherein the linker-SN-38 has a structure represented by: wherein n is between 1 and 30; AA is an L-amino acid residue selected from the group consisting of alanine, arginine, asparagine, aspartic acid, cysteine, glutamine, glutamic acid, glycine, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, proline, serine, threonine, tryptophan, tyrosine, and valine; and MAb is an IgG antibody or antigen-binding antibody fragment.