Patent ID: 9446056
Filing Date: 2016-09-20
CPC Classification: A61K,A61P

Claim Text:
1. A method of treating pain in a patient in need thereof comprising: parenterally administering over a period of about 15 to about 45 minutes to a patient in need thereof an emulsified celecoxib composition, the composition comprising between about 50 mg to about 800 mg of celecoxib, a discontinuous phase comprising an oil, a lecithin, and an aqueous continuous phase; wherein the celecoxib is present in an amount of about 0.6% w/w of the emulsion, or less; the weight ratio of celecoxib to lecithin is about 0.1:1 or less; the total amount of oil being in the composition is about 6% w/w or less; the combined amount of oil and lecithin being in the composition is about 12% w/w or less; and the emulsion has a viscosity of about from about 1 cps to about 1000 cps, or is filterable through a 0.2 micron filter wherein the celecoxib composition provides at least one of the following pharmacokinetic parameters: a mean peak plasma concentration (Cmax) from about 750 ng/ml to about 20,300 ng/ml; an AUC(0-12) from about 1400 hr*ng/mL to about 55,300 hr*ng/mL; a AUC last from about 1300 hr*ng/mL to about 55,300 hr*ng/mL; or an AUC(0-inf) from about 14000 hr*ng/mL to about 55,300 hr*ng/mL; a total apparent volume of distribution (Vss) from about 100 L to about 180 L; or a total apparent volume of distribution (Vss) of said administration of nanoemulsion composition is less than 50 percent compared to total apparent volume of distribution (Vss) of CELEBREX® 200 MG or CELEBREX® 400 MG.