Patent ID: 9452138
Filing Date: 2016-09-27
CPC Classification: A61K,A61P,C07K

Claim Text:
1. A formulation comprising: (a) a biologic therapeutic; and (b) a plurality of hydrophilic polymer strands comprising a functional group capable of inter-polymer cross-linking; wherein the plurality of hydrophilic polymer strands comprises PEG-acrylate and PEG-thiol; wherein the weight ratio of the biologic therapeutic to the plurality of hydrophilic polymer strands is between 1:1 and 1:125; wherein said formulation, when cross-linked, forms a hydrogel that exhibits reversible precipitation of the biologic therapeutic into precipitates having a size of about 50 nm to about 10 μm in diameter, and exhibits a triphasic release profile of the biologic therapeutic.