Patent ID: 9493400
Filing Date: 2016-11-15
CPC Classification: C07B,C07C

Claim Text:
1. A processes for preparing a compound of formula IA: comprising the steps of: a. alkylating an imine carboxylate of formula IIA with methallyl halide to form a substituted imine of formula IIIA; b. deprotecting the substituted imine of formula IIIA with an acid to yield an amine of formula IVA; c. resolving the amine of formula IVA with a chiral protic acid selected from the group consisting of D-(+)-camphor-10-sulfonic acid, D-BOC-proline, di-p-tolyl-D-tartaric acid, N-acetyl-D-phenyl alanine and mixtures thereof, in the presence of 5-nitrosalicylaldehyde; d. fluorinating the resolved amine to yield the compound of formula IA; wherein X is H