Patent ID: 9458202
Filing Date: 2016-10-04
CPC Classification: A61K,A61P,C07K,G01N

Claim Text:
1. A method of screening for an improved alpha-helical polypeptide with an increased in vivo half-life comprising: a. providing a parent alpha-helical polypeptide; b. installing at least one cross-link in the parent alpha-helical polypeptide, thereby resulting in a cross-linked polypeptide of Formula (I): wherein: each R L is alkyl, alkenyl or alkynyl; c. determining an apparent affinity (K d. determining the in vivo half-life of the cross-linked polypeptide relative to the parent alpha-helical polypeptide; and e. selecting the cross-linked polypeptide as an improved alpha-helical polypeptide, if the K