Patent ID: 9260492
Filing Date: 2016-02-16
CPC Classification: A61K,A61P,C07K,C12N

Claim Text:
1. A mutein of human Lipocalin 2 (hNGAL) comprising amino acid substitutions at nine or more of any of the sequence positions corresponding to sequence positions 36, 40, 41, 49, 52, 68, 70, 72, 73, 77, 79, 81, 96, 100, 103, 106, 125, 127, 132, and 134 of the linear polypeptide sequence of hNGAL (SEQ ID NO: 27), wherein the mutein is capable of binding glypican-3 (GPC3) with an affinity by a K D of about 10 nM or lower.