Patent ID: 9434785
Filing Date: 2016-09-06
CPC Classification: A61K,C07K,G01N

Claim Text:
1. A method of treating or preventing graft versus host disease (GvHD) in a human subject in need thereof, comprising: administering an anti-OX40L antibody or fragment thereof that antagonizes specific binding of OX40 to OX40L to a subject determined to have a ratio of CD45RA+CCR7+CD95+OX40+ T stem cell memory (Tscm) cells to CD45RA+CCR7+CD95− T-naive (Tn) cells greater than 50:50 wherein the antibody or fragment thereof is administered in an amount effective to reduce the ratio of said Tscm cells in said human, wherein a blood sample obtained from the human subject has been subjected to an assay to measure the ratio of CD45RA+CCR7+CD95+OX40+ Tscm:CD45RA+CCR7+CD95− Tn cells in the sample.