Patent ID: 9375489
Filing Date: 2016-06-28
CPC Classification: A61K,A61N,A61P,B01D,C07K

Claim Text:
1. A method of delivering SN-38 to a target cell comprising: a) producing a compound, CL2A-SN-38, of the structure,  by a reaction scheme as shown:  wherein the reaction scheme further comprises reacting SN-38 with tert-butyldimethylsilyl chloride (TBDMS-Cl) to produce 10-O-TBDMS-SN-38 (intermediate 4), wherein the reaction is carried out in dichloromethane solvent; b) attaching an antibody or antigen-binding antibody fragment to the CL2A-SN-38 to produce a mAb-CL2A-SN-38; and c) administering the mAb-CL2A-SN-38 to a subject.