Patent ID: 9458508
Filing Date: 2016-10-04
CPC Classification: A61P,C07K,C12N,C12Q,G01N

Claim Text:
1. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of: a) the nucleotide sequence set forth in SEQ ID NO: 25; b) a nucleotide sequence encoding the amino acid sequence set forth in SEQ ID NO: 26; or c) a nucleotide sequence having at least 95% sequence identity to SEQ ID NO:25 or a nucleotide sequence encoding an amino acid sequence having at least 95% sequence identity to SEQ ID NO:26, wherein the nucleotide sequence encodes a polypeptide having an arginine residue at the position corresponding to amino acid residue position 87 of SEQ ID NO:26, and wherein the nucleotide sequence encodes a polypeptide having kinase activity that is resistant to at least one ALK small-molecule kinase inhibitor.