Patent ID: 9326950
Filing Date: 2016-05-03
CPC Classification: A61K,A61P

Claim Text:
1. A method of preparing nanoparticles, which method comprises: (a) combining (i) an aqueous solution and (ii) an isolated peptide consisting of about 20 to about 25 amino acids of a transmembrane domain of CXCR4, wherein the carboxyl terminus of the peptide has 2 or 3 consecutive negatively charged residues, (b) adding a hydrophilic oligomer to the terminus of the peptide that contains 2 or 3 negatively charged residues, and (c) allowing the peptide to self-assemble into nanoparticles having a uniform shape and diameter, and wherein the hydrophilic oligomer is polyethylene glycol (PEG) having 11 to 27 monomeric units.