Patent ID: 9381178
Filing Date: 2016-07-05
CPC Classification: A61K,A61P

Claim Text:
1. A compound of the formula: or a pharmaceutically acceptable salt thereof, wherein X and R 1 are connected through a Linker Unit and X is selected from the group consisting of —NH—, —NR 8 —, —S—, —O—, —CH 2 —, —CHR 8 —, —CHR 8 R 9 —, —OC(═O)—, —N(R 3 )S(═O)—, and —N(═N)—; R 1 represents an Affinity Moiety selected from the group consisting of an antibody, an antibody fragment, a receptor protein, a peptidic growth factor, an anti-angiogenic protein, a specific binding peptide, a protease cleavable peptide, a glycopeptide, a peptide, a natural peptidic toxin, a protein toxin and an oligonucleotide; R 3 , R 4 , R 5 , R 6 , and R 7 each independently represent —H, -, —OH, —OCH 3 , —OC(═O)CH 3 —CH 3 , —CH 2 —CH 3 , —CH—(CH 3 ) 2 , —C(CH 3 ) 3 , —CH 2 —CH 2 —CH 3 , —CH 2 —CH—(CH 3 ) 2 , —CH—C—(CH 3 ) 3 , —C(═O)CH 3 ,—CH 2 OH, and —(C 1 -C 4 )alkyl; R 8 , and R 9 each independently represent —CH 2 —, -, —CH 2 —CH 2 —, —CH(CH 3 )—CH 2 —, —C(CH 3 ) 2 —CH 2 —, —CH 2 —CH 2 —CH 2 —, —CH 2 —CH(CH 3 )—CH 2 —, —CH—C(CH 3 ) 2 —CH 2 —, —C(═O)CH 2 —, —CH 2 O—; where the Linker Unit is selected from the group consisting of 4-fluorosulfonyl benzoyl, 3-fluorosulfonyl benzoyl and 2-fluorosulfonyl benzoyl.