Patent ID: 9446055
Filing Date: 2016-09-20
CPC Classification: A61K,A61P

Claim Text:
1. A disintegrating particle composition, which is prepared by a process comprising dispersing in an aqueous solvent at least one inorganic excipient, at least one disintegrant, carmellose, mannitol and xylitol to obtain a dispersion, and then spray-drying the dispersion to obtain complex particles, wherein (a) the mannitol is in the amount of 70 to 85 parts by weight; (b) the xylitol is in the amount of 1 to 5 parts by weight; (c) the inorganic excipient(s) are in the amount of 2 to 9 parts by weight and are selected from the group consisting of magnesium aluminometasilicate, magnesium aluminosilicate, aluminum silicate, calcium silicate, magnesium silicate, anhydrous silicic acid and silicon dioxide; (d) the disintegrant(s) are in the amount of 2 to 9 parts by weight and are selected from the group consisting of low-substituted hydroxypropylcellulose, crystalline cellulose, croscarmellose sodium, carmellose sodium and crospovidone; (e) the carmellose is in the amount of 1 to 15 parts by weight, and the total amount of the ingredients (a) to (e) is 100 parts by weight.