Patent ID: 9498489
Filing Date: 2016-11-22
CPC Classification: A61K,A61P,C07H

Claim Text:
1. A method of treating cancer in a subject comprising: administering to the subject a therapeutically effective amount of 5-aza-2′-deoxycytidine that induces formation of AP sites in cancer cells of the subjects and an amount AP endonuclease inhibitor effective to potentiate the cytotoxicity of the 5-aza-2′-deoxycytidine to the cancer cells, the AP endonuclease inhibitor being a small molecule with a primary amine group that forms a covalent linkage with an aldehyde group of an AP site induced by 5-aza-2′-deoxycytidine, wherein the amount of the AP endonuclease inhibitor is an amount sufficient to sensitize the cancer cells without causing undue sensitization of normal cells.