Patent ID: 9440963
Filing Date: 2016-09-13
CPC Classification: A61K,A61P,C07D,C07K

Claim Text:
1. A method of treating an ocular condition in a subject in need thereof, the method comprising administering to the subject a therapeutically-effective amount of a compound that activates Tie-2, wherein the compound is of the formula: wherein: Aryl  wherein: or a pharmaceutically-acceptable salt, tautomer, or zwitterion thereof, and an agent that increases aqueous solubility of the compound that activates Tie-2, or the pharmaceutically-acceptable salt, tautomer, or zwitterion thereof as compared to solubility of the compound that activates Tie-2 or the pharmaceutically-acceptable salt, tautomer, or zwitterion thereof in absence of the agent, wherein the agent that increases solubility of the compound that activates Tie-2 or the pharmaceutically-acceptable salt, tautomer, or zwitterion thereof increases aqueous solubility of the compound that activates Tie-2 or the pharmaceutically-acceptable salt, tautomer, or zwitterion thereof by at least 10% at each of 5° C., ambient temperature, and 50° C., wherein the agent is a cyclodextrin.