Patent ID: 9365889
Filing Date: 2016-06-14
CPC Classification: C12Q,G01N

Claim Text:
1. A method for assessing a risk of progression of heart failure status in a test subject comprising: obtaining a whole blood sample from the test subject; allowing the whole blood sample to clot; centrifuging the whole blood sample in a tube that is free of anti-coagulant; removing the fluid from the tube thereby obtaining a serum sample; measuring a level of paraoxonase 1 (PON1) activity in the serum sample from the test subject by ultraviolet spectrophotometry; and comparing the level of PON1 activity in the test subject's serum sample with a control or baseline value based on levels of PON1 activity in serum samples from a population of control subjects; assigning a risk value to the test subject based on the level of PON1 activity in the test subject's serum sample; prescribing either an aggressive therapy or a normal therapy for heart failure based on the risk value; wherein a test subject whose level of PON1 activity is less than the control or baseline value is at risk of progression of heart failure status; and wherein the test subject's heart failure is selected from the group consisting of: systolic heart failure, diastolic heart failure, and left ventricular dysfunction.