Patent ID: 9334274
Filing Date: 2016-05-10
CPC Classification: A61P,C07D

Claim Text:
1. A method of treating a disease selected from myelofibrosis, primary myelofibrosis (PMF), polycythemia vera (PV), essential thrombocythemia (ET), post polycythemia vera myelofibrosis (Post-PV MF), post essential thrombocythemia myelofibrosis (Post-ET MF), multiple myeloma, pancreatic cancer, breast cancer, lung cancer, colorectal cancer, rheumatoid arthritis, a skin disorder, lymphoma, leukemia, acute myelogenous leukemia, acute lymphoblastic leukemia, chronic myelogenous leukemia (CML), chronic myelomonocytic leukemia (CMML), graft versus host disease, cachexia, and Castleman's disease in a patient in need thereof, comprising administering to said patient a therapeutically effective amount of a compound of Formula I: or a pharmaceutically acceptable salt or N-oxide thereof; wherein: X is cyano or halogen; Y is CH or N; Z is hydrogen, C Ar is C each R each R each R each R or any R or any R each R each R provided that the valency of each atom in the optionally substituted moieties is not exceeded.