Patent ID: 9364569
Filing Date: 2016-06-14
CPC Classification: A61K,A61P

Claim Text:
1. A method for preparing a lyophilized matrix which, upon contact with an aqueous carrier liquid and a gas, is reconstitutable into a suspension of gas-filled microbubbles stabilized predominantly by a phospholipid, said method comprising the steps of: a) preparing an aqueous-organic emulsion comprising i) an aqueous medium including water, ii) an organic solvent substantially immiscible with water; iii) an emulsifying composition of amphiphilic materials comprising more than 50% by weight of a phospholipid and iv) a lyoprotecting agent, wherein the emulsion is substantially free of a structure builder selected from the group consisting of cholesterol and cyanacrylate and the temperature of the emulsion is lower than the boiling temperature of the organic solvent; and b) lyophilizing said emulsified mixture, to obtain a lyophilized matrix comprising said phospholipid.