Patent ID: 9505733
Filing Date: 2016-11-29
CPC Classification: C07B,C07D

Claim Text:
1. A synthesis of compound (3) comprising (a) reacting an o-cyano substituted aryl alkene of Formula I with AD-mix-β in the presence of a solvent at room temperature ranging between 25-35° C. for a period ranging between 3-7 h to form a cyclic amino ether (b) hydrolyzing the cyclic amino ether with water to form the lactone of Formula II; wherein AD-mix-β comprises potassium osmate K wherein R to form compound (21) (c) carrying out Barton-Mccombie deoxygenation of compound (21) with 1,1-thiocarbonyl diimidazole in the presence of dichloromethane as solvent at 25-35° C. for 10-14 h followed by treatment with tributyltinhydride in the presence of catalytic amount of azobisisobutyronitrile for 20-40 min to obtain compound (3).