Patent ID: 9296826
Filing Date: 2016-03-29
CPC Classification: A61K,A61P,C07K,C12N,C12Y

Claim Text:
1. An isolated antibody or antigen binding fragment thereof comprising one or more polypeptides that specifically binds to the extracellular domain of the transmembrane E3 ubiquitin ligase ZNRF3, wherein said one or more polypeptides are selected from the group consisting of: (a) one or more polypeptides having six regions, comprising: (b) one or more polypeptides having six regions, comprising: (c) one or more polypeptides having six regions, comprising: (d) one or more polypeptides having six regions, comprising: (e) one or more polypeptides having six regions, comprising: (f) one or more polypeptides having six regions, comprising: (g) one or more polypeptides having six regions, comprising: (ii) three regions from the amino terminus of the antibody or antigen binding fragment to the carboxyl terminus: a first region of having a peptide sequence of SEQ ID NO: 94; a second region having a peptide sequence of SEQ ID NO: 95; and a third region having a peptide sequence selected from the group consisting of SEQ ID NO: 96; and (h) one or more polypeptides having six regions, comprising: (ii) three regions from the amino terminus of the antibody or antigen binding fragment to the carboxyl terminus: a first region of having a peptide sequence of SEQ ID NO: 100; a second region having a peptide sequence of SEQ ID NO: 101; and a third region having a peptide sequence selected from the group consisting of SEQ ID NO: 102; and (i) one or more polypeptides having six regions, comprising: (j) one or more polypeptides having six regions, comprising: (k) one or more polypeptides having six regions, comprising: (ii) three regions from the amino terminus of the antibody or antigen binding fragment to the carboxyl terminus: a first region of having a peptide sequence of SEQ ID NO: 118; a second region having a peptide sequence of SEQ ID NO: 119; and a third region having a peptide sequence selected from the group consisting of SEQ ID NO: 120; and one or more polypeptides having six regions, comprising: (m) one or more polypeptides having six regions, comprising: (n) one or more polypeptides having six regions, comprising: (o) one or more polypeptides having six regions, comprising: (p) one or more polypeptides having six regions, comprising: (q) one or more polypeptides having six regions, comprising: (r) one or more polypeptides having six regions, comprising: