Patent ID: 9372245
Filing Date: 2016-06-21
CPC Classification: G01R

Claim Text:
1. A method of determining a novel magnetization transfer (NMT) effect associated with aliphatic protons of labile macro molecules and chemical exchange saturation transfer (CEST) contrast in an acquired magnetic resonance image of biological tissues, comprising the steps of: acquiring z-spectral data of the biological tissues at different offset frequencies of the acquired magnetic resonance image of the biological tissues; modeling conventional magnetization transfer (CMT) effect contributions to the acquired z-spectral data; removing the modeled CMT effect contributions from the z-spectral data; modeling a direct water saturation component using the z-spectral data without the modeled CMT effect contributions; removing the modeled direct water saturation component contribution from the z-spectral data with removed CMT spectrum to leave CEST and NMT contrast components at respective frequencies of interest; and providing the CEST and NMT contrast components at the respective frequencies of interest on the acquired magnetic resonance image of the biological tissues.