Patent ID: 9339450
Filing Date: 2016-05-17
CPC Classification: A61K,A61L,A61P,A61Q

Claim Text:
1. A composition for subcutaneous or intradermal injection consisting of: a mechanical filling agent, wherein non-chemically cross-linked hyaluronic acid, or one of its salts, is the mechanical filling agent; and a fibroblast growth medium free of fetal calf serum (FCS), wherein the fibroblast growth medium comprises; sodium chloride in a final concentration ranging from 5000 to 8000 mg/l; L-glutamine or L-alanyl-glutamine in a final concentration ranging from 100 to 3000 mg/l; sodium bicarbonate in a final concentration ranging from 0 to 2000 mg/l; D-glucose in a final concentration ranging from 2000 to 5000 mg/l; L-arginine HCl in a final concentration ranging from 300 to 500 mg/l; sodium acetate in a final concentration ranging from 200 to 450 mg/l; disodium phosphate (Na L-leucine in a final concentration ranging from 50 to 200 mg/L; L-serine in a final concentration ranging from 50 to 200 mg/L; magnesium chloride (MgCl potassium chloride in a final concentration ranging from 50 to 200 mg/L; L-valine in a final concentration ranging from 20 to 150 mg/L; sodium pyruvate in a final concentration ranging from 10 to 75 mg/L; L-lysine HCl in a final concentration ranging from 10 to 75 mg/L; L-histidine HCl H L-cysteine HCl H adenine HCl in a final concentration ranging from 5 to 50 mg/L; L-threonine in a final concentration ranging from 5 to 50 mg/L; calcium chloride (CaCl myo-inositol in a final concentration ranging from 5 to 50 mg/L; L-glutamic acid in a final concentration ranging from 15 to 75 mg/L; L-asparagine H L-methionine in a final concentration ranging from 10 to 50 mg/L; L-tyrosine 2Na L-phenylalanine in a final concentration ranging from 2 to 20 mg/L; L-tryptophan in a final concentration ranging from 2 to 20 mg/L; L-alanine in a final concentration ranging from 5 to 30 mg/L; glycine in a final concentration ranging from 5 to 30 mg/L; L-isoleucine in a final concentration ranging from 5 to 30 mg/L; L-aspartic acid in a final concentration ranging from 10 to 50 mg/l; sodium sulphate in a final concentration ranging from 1 to 10 mg/l; ferrous sulphate (FeSO folic acid in a final concentration ranging from 1 to 5 mg/l; thymidine in a final concentration ranging from 0.1 to 3 mg/l; cyanocobalamine in a final concentration ranging from 0.1 to 3 mg/l; d-calcium pantothenate in a final concentration ranging from 1 to 5 mg/l; thiamine HCl in a final concentration ranging from 1 to 5 mg/L; thioctic acid in a final concentration ranging from 0.1 to 1 mg/L; zinc sulphate (ZnSO sodium silicate (NA Pyridoxine HCl in a final concentration ranging from 0.5 to 3 mg/L; niacinamide (nicotinamide) in a final concentration ranging from 0.5 to 3 mg/L; riboflavin in a final concentration ranging from 0.05 to 0.5 mg/L; d-biotin in a final concentration ranging from 0.01 to 0.05 mg/L; copper sulphate (CuSO ammonium molybdate (NH ammonium vanadate (NH manganese chloride (MnCl sodium hyaluronate in a final concentration ranging from 100 to 1000 mg/L; L-proline in a final concentration ranging from 10 to 100 mg/l; hydroxyproline in a final concentration ranging from 10 to 100 mg/l; ascorbic acid in a final concentration ranging from 0.1 to 10 mg/l; adenosine in a final concentration ranging from 0.01 to 1 mg/l; guanine in a final concentration ranging from 0.01 to 1 mg/l; deoxyribose in a final concentration ranging from 0.01 to 1 mg/l; ribose in a final concentration ranging from 0.01 to 1 mq/l; choline chloride in a final concentration ranging from 0 to 3 mq/l; milk peptide complex in a final concentration ranging from 0 to 5000 mg/l; and water q.s. 1 liter, wherein the hyaluronic acid or one of its salts forms more than 0.07% of the total mass of the composition.