Patent ID: 9320750
Filing Date: 2016-04-26
CPC Classification: A61K,C07H

Claim Text:
1. A method for treating a cancer in a subject in need thereof, wherein the cancer is resistant to a DNA-damaging chemotherapeutic agent, the method comprising: administering to the patient an effective amount of a pharmaceutical composition comprising a liposome in a pharmaceutically effective excipient, wherein the liposome includes an aqueous interior layer and a lipophilic exterior layer, the lipophilic exterior layer including a hydrophobic inhibitor of an EGFR pathway, and the aqueous interior layer including a hydrophilic DNA-damaging chemotherapeutic agent, wherein the pharmaceutical composition further comprises a controlled release excipient, and wherein a therapeutically effective amount of the EGFR inhibitor is released at the time of administration, and a therapeutically effective amount of the DNA damaging agent is released at least four hours later.