Patent ID: 9382202
Filing Date: 2016-07-05
CPC Classification: A61K,C07C,C07F

Claim Text:
1. A method for manufacturing a precursor for labeling therapeutic agents of liver cancer comprising the steps of: producing L-Nε-tert-butoxycarbonyl-Nα-[2-(triphenylmethyl)thioacetyl]lysine methyl ester (hereafter called compound 1) by an amidation reaction between L-Nε-tert-butoxycarbonyllysine methyl ester and triphenylmethyl thio glycolic acid; hydrolyzing the compound 1 to produce L-Nε-tert-butoxycarbonyl-Nα-[2-(triphenylmethyl)thioacetyl]lysine (hereafter called compound 2); producing L-Nε-tert-butoxycarbonyl-Nα-[2-(triphenylmethyl)thioacetyl]-6-aza-5-oxo-9-(triphenyl methyl)thio-1,5-nonanediamine (hereafter called compound 3) by an amidation reaction between the compound 2 and 2-(triphenylmethyl)thio]ethylamine; decomposing the compound 3 by acid to produce L-Nε-[2-(triphenylmethyl)thioacetyl]-6-aza-5-oxo-9-(triphenylmethyl)thio-1,5-nonanediamine (hereafter called compound 4); and carrying out an amidation reaction between the compound 4 and oleic acid/or 6,7-diiodotetradecanoic acid to produce