Patent ID: 9464136
Filing Date: 2016-10-11
CPC Classification: A61P,C07K

Claim Text:
1. A bispecific antibody that specifically binds a first epitope on EGFR recognized by cetuximab and specifically binds a second, non-overlapping epitope on EGFR recognized by monoclonal antibody 806 (mAb 806), wherein the bispecific antibody comprises, an IgG and a scFv, wherein the IgG comprises a heavy chain comprising the three heavy chain complementarity determining regions (CDRs) of cetuximab and a light chain comprising the three light chain CDRs of cetuximab, wherein the scFv comprises the three heavy and three light chain CDRs of mAb 806, and wherein (i) the scFv is fused, directly or indirectly, to the carboxy terminus of the IgG heavy chain; or (ii) the scFv is fused, directly or indirectly, to the carboxy terminus of the IgG light chain.