Patent ID: 9370557
Filing Date: 2016-06-21
CPC Classification: A61K

Claim Text:
1. A method of generating a mucosal immune response against a peptide antigen, comprising administering to a subject a protein comprising a single chain of amino acids forming a fusion protein of said peptide antigen and a cytolysin, wherein said cytolysin is selected from the group consisting of pneumolysin from Streptococcus pneumoniae , perfringolysin O from Clostridium perfringens , intermedilysin from Streptococcus intermedius , alveolysin from Bacillus alvei , anthrolysin from Bacillus anthracis , putative cereolysin from Bacillus cereus , ivanolysin O from Listeria ivanovii , pyolysin from Arcanobacterium pyogenes , suilysin from Streptococcus suis , tetanolysin from Clostridium tetani , thuringiolysin O from Bacillus thuringiensis , botulinolysin from Clostridium botulinum , chauveolysin from C. chauvoei , bifermentolysin from C. bifermentans , sordellilysin from C. sordellii , histolyticolysin from Clostridium histiolyticum , novylysin from Clostridium novyi and septicolysin O from Clostridium septicum , and wherein said peptide antigen is derived from an infectious organism.