Patent ID: 9433636
Filing Date: 2016-09-06
CPC Classification: A61K,A61L,A61P

Claim Text:
1. An article of manufacture comprising a crosslinked hydrogel layer reacted from a fluid mixture containing chitosan and oxidized polysaccharide in amounts sufficient to form a protective gel layer in situ, the crosslinked hydrogel layer being in contact with and coating and conforming to the shape of cilia on a ciliated mucosal tissue in an ear, nasal cavity, sinus cavity or throat, the chitosan having a number average molecular weight before sterilization of at least about 50 kDa, and wherein the crosslinked hydrogel layer provides a protective gel layer that remains exposed to air or other nearby gases, reduces adhesions to anatomy, is biodegradable or bioresorbable without shedding large solid chunks and resists detachment or other disruption from such tissue until natural degradation or resorption of the protective gel layer takes place.