Patent ID: 9408815
Filing Date: 2016-08-09
CPC Classification: A61K

Claim Text:
1. A method of inhibiting metabolism of dextromethorphan in a human being comprising co-administering: 1) an oral dosage form containing bupropion, with 2) about 35 mg per day to about 500 mg per day of dextromethorphan to the human being once or twice a day for at least eight consecutive days, wherein the human being is an extensive metabolizer of dextromethorphan in need of treatment with dextromethorphan, and wherein on the eighth day that bupropion and dextromethorphan are co-administered, the co-administration results in an AUC 0-12 of dextromethorphan that is at least about 20 times the AUC 0-12 that would be achieved by administering the same amount of dextromethorphan without bupropion for eight consecutive days.