Patent ID: 9476045
Filing Date: 2016-10-25
CPC Classification: C12N

Claim Text:
1. A bio-cleavable oligonucleotide-ligand conjugate represented by the following formula: wherein: NA is a chemically modified or unmodified oligonucleotide; L is a ligand selected from the group consisting of a multivalent galactose and a multivalent N-acetyl-galactosamine;  represents a tether comprising one or more linking groups having a cleavable disulfide group (—SS—), wherein each  linking group is either present or absent;  is a cyclic carrier selected from the group consisting of hydroxyproline, piperidine, morpholine, piperazine, and decalin or acyclic carrier moiety containing a serinol backbone or a diethanolamine backbone; X is a chemical linkage between the ligand L and the tether; Y is a chemical linkage between the tether and the  and Z is a chemical linkage between the  and the oligonucleotide NA.