Patent ID: 9241996
Filing Date: 2016-01-26
CPC Classification: A61K,A61P

Claim Text:
1. A method for enhancing the activity of tyrosine kinase inhibitors in target cells, said method comprising: (a) contacting a cell with a photosensitizing agent, (b) irradiating said cell with light of a wavelength effective to activate the photosensitizing agent, and (c) contacting said cell with a tyrosine kinase inhibitor before, after, or during, or a combination thereof, said irradiating, wherein the photosensitizing agent is not a substrate for the ATP-binding cassette protein ABCG2, wherein the photosensitizing agent is a di- or tetra-sulfonated aluminium pthalocyanine, sulfonated tetraphenylporphine, sulfonated meso tetraphenyl chlorin or sulfonated tetraphenyl bacteriochlorin, and wherein said tyrosine kinase inhibitor is lapatinib, sunitinib, imatinib, gefitinib, dasatinib, nilotinib, erlotinib, tyrphostin (AG 1478), sorafenib or bosutinib or a pharmaceutically acceptable salt thereof.