Patent ID: 9260518
Filing Date: 2016-02-16
CPC Classification: A61K,A61P,C07K

Claim Text:
1. A monoclonal antibody that specifically binds the C-terminal of TFPI, wherein said C-terminal is amino acids 186-276 of TFPI (SEQ ID NO: 1), wherein said antibody comprises a heavy chain comprising a CDR1 sequence of amino acids 31 to 35 (SYYMY) of SEQ ID NO: 5; a CDR2 sequence of amino acids 50-66 (EINPSNGDTNLNEKFKS) of SEQ ID NO: 5; and a CDR3 sequence of amino acids 99-107 (WDRFDGFVY) of SEQ ID NO: 5; and a light chain comprising a CDR1 sequence of amino acids 24-34 (IISTNIDDDIN) of SEQ ID NO: 7; a CDR2 sequence of amino acids 50-56 (EGNTLRP) of SEQ ID NO: 7; and a CDR3 sequence of amino acids 89-97 (LQSDDLPYT) of SEQ ID NO: 7, or said antibody comprises a heavy chain comprising a CDR1 sequence of amino acids 31-35 (GYPMN) of SEQ ID NO: 9; a CDR2 sequence of amino acids 50-66 (LINPYNGDTTFNQKFKG) of SEQ ID NO: 9; and a CDR3 sequence of amino acids 99-106 (GTYEYVDY) of SEQ ID NO: 9; and a light chain comprising: a CDR1 sequence of amino acids 24-33 (SASSSVFYMH) of SEQ ID NO: 11; a CDR2 sequence of amino acids 49-55 (DTSILSS) of SEQ ID NO: 11; and a CDR3 sequence of amino acids 88-96 (QQWSSYPLT) of SEQ ID NO: 11, or said antibody comprises a heavy chain comprising a CDR1 sequence of amino acids 31-35 (TYWIH) of SEQ ID NO: 13; a CDR2 sequence of amino acids 50-66 (AIDPGNSDATYSQKFKD) of SEQ ID NO: 13; and a CDR3 sequence of amino acids 99-111 (EVYYGYDGDYFDY) of SEQ ID NO: 13; and a light chain comprising a CDR1 sequence of amino acids 24-38 (RASESVSVHGTHLMH) of SEQ ID NO: 15; a CDR2 sequence of amino acids 54-60 (AASKLES) of SEQ ID NO: 15; and a CDR3 sequence of amino acids 93-101 (QQSIGDPWT) of SEQ ID NO: 15.