Patent ID: 9399623
Filing Date: 2016-07-26
CPC Classification: A61K,A61P,C07D

Claim Text:
1. A compound of formula I, or a pharmaceutically acceptable salt thereof, wherein: R each R wherein when R wherein when R Z is O, S, SO Ring A is a 3-8 membered saturated or partially unsaturated carbocyclic ring, or a 3-7 membered heterocylic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; each R each R is independently hydrogen, C two R groups on the same atom are taken together with the atom to which they are attached to form a C m is 0, 1, or 2; and n is 1, 2, 3, 4, or 5; wherein, at least one of R wherein, the following compounds are excluded: 6-chloro-N-{[(1S,3S)-1-hydroxy-3-methylcyclohexyl]methyl}-2-[(3S)-3-hydroxypyrrolidin-1-yl]quinoline-5-carboxamide; 6-chloro-N-{[(1S,3S)-1-hydroxy-3-methylcyclohexyl]methyl}-2-[(3R)-3-hydroxypyrrolidin-1-yl]quinoline-5-carboxamide; 6-chloro-N-{[(1S,3S)-1-hydroxy-3-methylcyclohexyl]methyl}-2-(4-hydroxypiperidin-1-yl]quinoline-5-carboxamide; and 6-chloro-N-{[(1S,3S)-1-hydroxy-3-methylcyclohexyl]methyl}-2-(3-hydroxy-3-methylpyrrolidin-1-yl]quinoline-5-carboxamide.