Clue: Cryptically, how she runs home (9)
Answer: HOUSEWIFE
Explanation: Definition: she runs home
Not sure about this: I think the idea is that HOUSEWIFE is providing a cryptic indication of "how", but the best I can get is that it's HO and then you USE W[IFE]. I feel I must be missing something. (In Ximemes' book "The Art of the Crossword" he describes clueing HOUSEWIFE as an &lit: "I have plenty of time to stitch, then I iron" – HOU[R] + SEW + I FE – which is very clever, if rather showing its age.)*Thanks to Shirl: it's just that HOUSEWIFE = HOUSE + WIFE = HO + W = HOW.