Clue: Che Guevara perhaps in US city, revolutionary air around me in target of 6 22? (5-8)
Answer: LATIN-AMERICAN
Explanation: Definition: Che Guevara perhaps
A charade of LA (Los Angeles, 'US city') plus TINAMERICAN, a double envelope ('around' and 'in') of 'me' in ARI, an anagram ('revolutionary') of 'air' in TIN CAN ('target of 6 22?').