Clue: Target of 6 22, M&M and Eminem by the sound of it? (5,7)
Answer: SWEET WRAPPER
Explanation: Definition: Target of 6 22
A charade of SWEET (candy, 'M&M', for example) plus WRAPPER, sounding like ('by the sound of it') RAPPER ('Eminem', again an example, again justified by the question mark).