Clue: Destroy vessel crossing river with unlimited brio (8)
Answer: VAPORISE
Explanation: Definition: Destroy
 VASE(a vessel/jar used for holding cut flowers or as an ornament) **containing**(crossing) [ PO(river in Italy) **plus**(with) "brio" **minus its 1st and last letters**(unlimited …) ].
Defn: To … something by turning it into gas through extreme heat.