Clue: Quixote's foe's child replacing male and female player – it makes you shiver! (4,5,6)
Answer: WIND CHILL FACTOR
Explanation: Quixote's foe's child replacing male and female player – it makes you shiver! (4,5,6)

**WIND**(m>**CH**)**ILL** ("Quixote's foe", with CH (child) replacing M (male))+ **F** (female) + **ACTOR** ("player")