Clue: Drug satisfied husband in the morning, dear, keeping hard with a source of supply (15)
Answer: METHAMPHETAMINE
Explanation: Drug satisfied husband in the morning, dear, keeping hard with a source of supply (15)
**MET** ("satisfied") + **H** (husband) +**AM** ("in the morning") + **PET** ("dear) *keeping* **H** (hard) *with* **A MINE** ("source of supply")