Clue: Unwell, a guy is uncomfortable (3,2,4)
Answer: ILL AT EASE
Explanation: Unwell, a guy is uncomfortable (3,2,4)
**ILL** ("unwell") + **A** + **TEASE** ("guy") 
*Hadn't come across "guy" equal to "tease" before, but Chambers includes "joke" or "lark" as archaic meanings of "guy"