Clue: Head of science institute loaned old Scot original English work featuring 1, 8 or the 28? (6,7)
Answer: SILENT PICTURE
Explanation: Definition: work featuring 1, 8 or the 28?
[*head of*] **S**(cience) + **I** (institute) +** LENT** ("loaned") + **PICT** ("old Scot") + **UR** (prefix meaning "original") + **E** (English)