Clue: Enjoying a good relationship? First Lady's reticent at first — I wasn't expecting that … (4,1,5)
Answer: WELL I NEVER
Explanation: Enjoying a good relationship? First Lady's reticent at first — I wasn't expecting that … (4,1,5)
**WELL IN** ("enjoying a good relationship") + **EVE** ("first lady") + **R**(eticent) [*at first*]