Clue: Someone having tooth extracted that likely heads for small town in Eastern Europe? (6)
Answer: SHTETL
Explanation: Definition: small town in Eastern Europe?
*Heads* of **S**(oneone) **H**(aving) **T**(ooth) **E**(xtracted) **T**(hat) **L**(ikely) 
*A shtetl is a small Jewish community in Eastern Europe