Clue: Misery of O'Connor and Lynam collaboration? (7)
Answer: DESPAIR
Explanation: Definition: Misery

DES O'Connor and DES Lynam could be considered a pair of Des's or a **DES-PAIR**
 

 
*Des O'Connor was an English comedian and presenter who died in 2020 and Des Lynam is a sports presenter and former host of *Countdown*.