Clue: Fearsome female artist seen in European port (6)
Answer: VIRAGO
Explanation: Definition: Fearsome female 
R.A. (artist) "seen in" VIGO (port in Spain, so "European port") 
*R.A. stands for Royal Academy of Arts, which is an institution set up by King George III in 1768 to promote art. In crosswordland, RA and "artist" are interchangeable terms.