### Clue: Establishing distance from two directions before time rambling (10)
### Answer: ESTRANGING 
 ### Explanation: Definition: Establishing distance from
 E,S(abbrev. for two directions, east and south respectively) **plus**(before) T(abbrev. "time") + RANGING(rambling/spreading in different directions).
Defn: …/causing to be no longer be friendly terms/to be distant.