### Clue: Hot with it, 101 leave lewd and unhealthy (12)
### Answer: INSALUBRIOUS 
 ### Explanation: Hot with it, 101 leave lewd and unhealthy (12)
**IN** ("hot") + **SA** (sex appeal, so "it") + **LUBRI**(ci)**OUS** ("lewd", with CI ("101") *leaving*)