Patent ID: 11873518
Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
Field: Biotechnology (Chemistry)
Classification: CPC C | IPC C

Claim 8:
9. The isolated nucleic acid of claim 1, wherein the polypeptide comprises:
(a) an activating mutation at positions corresponding to residue 139 of SEQ ID NO:2;
(b) an activating mutation at positions corresponding to residues 139, 165, and 301 of SEQ ID NO:2;
(c) an activating mutation at positions corresponding to residues 139, and 212 of SEQ ID NO:2;
(d) an activating mutation at positions corresponding to residues 139, 183, and 212 of SEQ ID NO:2; or
(e) an activating mutation at positions corresponding to residues 139, 183, 186, and 212 of SEQ ID NO:2.