Patent ID: 11857604
Assignee: NH THERAGUIX
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  B | IPC A  B

Claim 19:
20. A method for preparing a nanovector according to claim 1, said method comprising mixing two solutions:
a. a first solution comprising a nanoparticle, said nanoparticle being a polysiloxane-based nanoparticle having a mean diameter of less than 10 nm, wherein said nanoparticle comprises polysiloxanes with a weight ratio of silicon of at least 8% of the total weight of the nanoparticle and a chelating agent grafted onto the nanoparticle, wherein the chelating agent which is grafted onto the nanoparticle is selected from DOTA, DTPA, EDTA, EGTA, BAPTA, NOTA, DOTAGA and DTPABA or a mixture thereof, and
b. a second solution comprising an active substance chosen from organic molecules having a molecular weight of between 2% and 40% of the molecular weight of said nanoparticle, under concentration ratio, pH and temperature conditions which allow an interaction by physisorption of the active substance at the surface of said nanoparticle.