Patent ID: 11866789
Assignee: THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A  G | IPC A  C  G

Claim 0:
1. A method of treating a patient with cholangiocarcinoma cancer, the method comprising the steps of:
analyzing a sample from a patient with cholangiocarcinoma cancer for a DNA translocation in chromosome 8 band 12 p;
identifying a RBPMS-NRG1 fusion event transcribed by the DNA translocation in chromosome 8 band 12 p having a breakpoint between the 5′ end of exon 5 of the RBPMS portion and the 3′ end of exon 2 of the NRG1 portion, wherein the NRG1 portion of the RBPMS-NRG1 fusion event retains a EGF-like domain on the NRG1 portion; and
administering to the patient, having the RBPMS-NRG1 fusion event, a treatment of a therapeutic agent comprising at least one EGFR inhibitor that is targeted for the EGF-like domain of the NRG1 portion of the RBPMS-NRG1 fusion event.