Patent ID: 11891726
Assignee: DSM IP ASSETS B.V.
Field: Pharmaceuticals (Chemistry)
Classification: CPC D  A  C | IPC A  C  D

Claim 0:
1. A method for treating a condition associated with the eye of a patient comprising the step of implanting a fiber into the eye of the patient, wherein the step of implanting comprises intravitreal or subconjunctival implantation of a fiber having an average diameter between 50 and 500 micrometers, the fiber comprising a bioactive agent dispersed in a biodegradable poly(esteramide) copolymer (PEA) according to structural Formula (IV),, , wherein
m+p is from 0.9 to 0.1 and q is from 0.1 to 0.9;
m+p+q=1, whereby m and p are each greater than 0;
n is about 5 to about 300;
a is at least 0.05, b is at least 0.05, a+b=1, qa=q*a, and qb=q*b; wherein units of m, units of p, units of qa, and units of qb are all randomly distributed throughout the copolymer;
R1 is (C2-C20) alkylene;
R3 and R4 are independently selected from hydrogen, (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, (C6-C10)aryl, —CH2SH, —(CH2)2S(CH3), —CH2OH, —CH(OH)CH3, —(CH2)4NH3+, —(CH2)3NHC(═NH2+)NH2, —CH2COOH, —CH2—CO—NH2, —CH2CH2—CO—NH2, —CH2CH2COOH, CH3—CH2—CH(CH3)—, (CH3)2CH—CH2—, H2N—(CH2)4—, Ph-CH2—, CH═C—CH2—, (CH3)2CH—, or Ph-NH—;
R5 is (C2-C20)alkylene;
R6 is according to structural formula (III);, R7 is (C6-C10)aryl(C1-C6)alkyl; and
R8 is —(CH2)4—.