Patent ID: 11942223
Assignee: IMMUNEERING CORPORATION
Field: Computer technology (Electrical engineering)
Classification: CPC G  A | IPC G

Claim 23:
24. A method for identifying a candidate therapy for treatment of a disease, the method comprising:
(a) identifying, by a processor of a computing device, a first gene set comprising differentially expressed genes of cells indicative of the disease as compared to cells not indicative of the disease, wherein the first gene set is represented as a first numeric vector comprising weighted values corresponding to gene expression data of the differentially expressed genes of the first gene set;
(b) for each of a plurality of candidate therapies causing changes in gene expression of cells:
(i) identifying, by the processor, a second gene set corresponding to said candidate therapy, wherein the second gene set is represented as a second numeric vector comprising weighted values corresponding to gene expression data of differentially expressed genes of cells treated with said candidate therapy as compared to cells not treated with said candidate therapy; and
(ii) determining, by the processor, a measure of similarity between the first gene set and the second gene set using the first numeric vector and the second numeric vector, wherein the measure of similarity is a function of an angle between the first numeric vector and the second numeric vector; and

(c) identifying, by the processor, one or more members of the plurality of candidate therapies as candidates for treatment of the disease using the measures of similarity.