Patent ID: 11959083
Assignee: SECARNA PHARMACEUTICALS GMBH & CO. KG
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 1:
2. The oligonucleotide of claim 1, wherein the oligonucleotide is selected from the group consisting of, (A04053H, SEQ ID NO: 89)

+T*+A*+C*G*T*T*C*A*C*T*A*C*C*T*+T*C*+T,

 

(A04052H, SEQ ID NO: 89)

+T*+A*+C*G*T*T*C*A*C*T*A*C*C*T*+T*+C*+T,

 

(A04055H, SEQ ID NO: 91)

+T*+A*+G*T*A*A*G*C*C*C*T*G*+A*+T*+G,

 

(A04040H, SEQ ID NO: 3)

+G*+T*+T*T*G*T*G*T*G*A*G*A*G*C*+T*+T,

 

(A04045H, SEQ ID NO: 4)

+C*+A*+C*T*T*A*C*G*T*T*C*A*C*T*+A*+C*+C,

 

(A04062H, SEQ ID NO: 97)

+G*G*+T*T*T*G*T*G*T*G*A*G*+A*G*+C,

 

(A04059H, SEQ ID NO: 94)

+G*+G*+T*T*T*G*T*G*T*G*A*G*A*G*C*+T*+T,

 

(A04060H, SEQ ID NO: 95)

+G*+G*+T*T*T*G*T*G*T*G*A*G*A*G*C*+T,

 

(A04019H, SEQ ID NO: 23)

+G*+T*+A*A*G*C*C*C*T*G*A*T*+G*+T*+T,

 

(A04003H, SEQ ID NO: 7)

+T*+T*+G*A*A*C*A*C*T*G*C*+G*+A*+T,

 

(A04004H, SEQ ID NO: 8)

+G*+C*C*A*T*A*G*G*C*A*C*C*+T*+T*+C,

 

(A04005H, SEQ ID NO: 9)

+C*+T*+A*T*G*C*T*G*A*A*C*C*+A*+C*+C,

 

(A04006H, SEQ ID NO: 10)

+T*G*+T*A*G*A*G*G*C*T*C*C*C*+C*+C,

 

(A04007H, SEQ ID NO: 11)

+T*+T*+G*C*A*G*A*G*C*A*T*T*+A*+T*+C,

 

(A04008H, SEQ ID NO: 12)

+A*+G*+G*C*G*A*A*A*T*T*G*C*+A*+G*+A,

 

(A04009H, SEQ ID NO: 13)

+T*+A*G*A*C*A*T*T*G*T*A*G*+T*+C*+C,

 

(A04010H, SEQ ID NO: 14)

+G*+A*G*T*G*C*C*T*G*A*T*C*C*+T*+T,

 

(A04011H, SEQ ID NO: 15)

+A*+A*+T*C*C*C*C*C*T*G*G*A*+G*+T*+G,

 

(A04012H, SEQ ID NO: 16)

+A*+G*+C*G*T*A*A*G*A*T*G*T*+T*+T*+T,

 

(A04013H, SEQ ID NO: 17)

+A*+C*+T*C*C*A*G*C*G*T*A*A*+G*+A*+T,

 

(A04014H, SEQ ID NO: 18)

+T*+G*+A*T*A*G*C*C*T*T*G*C*+A*+G*+A,

 

(A04015H, SEQ ID NO: 19)

+A*+G*T*C*C*A*G*C*C*G*G*C*G*T*+C,

 

(A04016H, SEQ ID NO: 20)

+G*G*+A*C*A*A*T*G*G*T*T*G*+C*+T*+C,

 

(A04017H, SEQ ID NO: 21)

+C*+T*+T*G*A*A*C*A*C*T*G*C*+G*+A*+T,

 

(A04018H, SEQ ID NO: 22)

+G*+A*G*T*A*C*A*A*C*T*G*A*+A*+C*+C,

 

(A04020H, SEQ ID NO: 24)

+T*+A*+T*G*G*T*A*C*A*G*T*+T*G*+G*+T,

 

(A04021HM, SEQ ID NO: 25)

+C*+T*+G*A*C*T*G*A*A*T*T*T*G*+C*+C*+C,

 

(A04022HM, SEQ ID NO: 26)

+A*+C*+T*A*T*G*C*T*G*A*A*C*C*A*+C*+C,

 

(A04023HM, SEQ ID NO: 27)

+G*+A*C*T*A*T*G*C*T*G*A*A*C*+C*+A*+C,

 

(A04024HM, SEQ ID NO: 28)

+G*+A*+G*G*C*G*A*A*A*T*T*G*C*A*+G*+A,

 

(A04025H, SEQ ID NO: 29)

+A*+G*A*G*T*G*C*C*T*G*A*T*C*C*+T*+T,

 

(A04026H, SEQ ID NO: 30)

+G*+A*+T*A*G*T*T*T*C*C*A*A*T*+A*+C*+C,

 

(A04027H, SEQ ID NO: 31)

+T*+A*+C*T*C*C*A*G*C*G*T*A*A*+G*+A*+T,

 

(A04028H, SEQ ID NO: 32)

+A*+T*+G*T*A*G*C*C*C*A*A*A*G*T*+C*+C,

 

(A04029H, SEQ ID NO: 33)

+C*+A*+T*G*T*A*G*C*C*C*A*A*A*+G*+T*+C,

 

(A04030H, SEQ ID NO: 34)

+G*+G*+A*C*A*A*T*G*G*T*T*G*C*+T*C*+A,

 

(A04031H, SEQ ID NO: 35)

+A*+G*+C*C*T*A*T*G*A*T*G*G*C*C*+A*+C,

 

(A04032H, SEQ ID NO: 36)

+G*+C*+C*T*T*G*A*A*C*A*C*T*G*C*+G*+A,

 

(A04033H, SEQ ID NO: 37)

+A*+C*C*C*T*G*A*G*T*T*G*T*A*A*C*+T,

 

(A04034H, SEQ ID NO: 38)

+A*+G*G*A*T*A*G*T*C*T*T*G*T*C*+T*+C,

 

(A04035H, SEQ ID NO: 39)

+C*C*T*A*C*C*C*A*G*G*A*T*A*G*+T*+C,

 

(A04036H, SEQ ID NO: 40)

+C*+C*+C*T*C*T*C*A*C*T*A*A*A*+T*+T*+A,

 

(A04037H, SEQ ID NO: 41)

+A*+C*+T*C*C*A*C*A*C*T*A*A*T*+G*+C*+T,

 

(A04038H, SEQ ID NO: 42)

+G*T*+C*A*A*T*C*C*T*G*C*T*C*A*+A*+C,

 

(A04039H, SEQ ID NO: 43)

+C*+A*+G*T*C*A*A*T*C*C*T*G*C*+T*+C*+A,

 

(A04041HM, SEQ ID NO: 44)

+C*T*+T*G*C*C*A*T*A*G*A*G*G*C*+G*A*+A,

 

(A04042H, SEQ ID NO: 45)

+T*+G*+C*C*A*G*A*G*T*G*C*C*T*G*+A*+T*+C,

 

(A04043H, SEQ ID NO: 46)

+A*+C*+G*T*T*C*A*C*T*A*C*C*T*T*+C*+T*+T,

 

(A04044H, SEQ ID NO: 47)

+T*+T*+A*C*G*T*T*C*A*C*T*A*C*C*+T*+T*+C,

 

(A04046H, SEQ ID NO: 48)

+A*+A*+G*G*T*C*A*C*T*T*A*C*G*T*+T*+C*+A,

 

(A04047H, SEQ ID NO: 49)

+G*+C*+C*C*C*A*A*A*A*T*C*C*C*C*+C*+T*+G,

 

(A04048H, SEQ ID NO: 50)

+G*+A*+G*A*G*A*A*T*G*T*A*G*G*T*+A*C*+C,

 

(A04049H, SEQ ID NO: 51)

+C*+C*C*T*G*G*A*T*C*T*T*G*C*C*+A*+A*+T,

 

(A04050H, SEQ ID NO: 52)

+A*+A*+A*G*T*C*C*A*G*C*C*G*G*C*G*+T*+C,

 

(A04051H, SEQ ID NO: 88)

+A*+G*+A*G*T*G*C*C*T*G*A*T*C*+C*+T*+T,

 

(A04054H, SEQ ID NO: 90)

+G*+C*+C*C*T*G*A*T*G*T*T*T*G*+A*+A*+T,

 

(A04056H, SEQ ID NO: 92)

+G*+T*+T*T*G*T*G*T*G*A*G*A*G*C*+T*+T*+T,

 

(A04058H, SEQ ID NO: 93)

+T*+T*+T*G*T*G*T*G*A*G*A*G*+C*+T*+T,

 

(A04061H, SEQ ID NO: 96)

+G*+T*+T*T*G*T*G*T*G*A*G*A*G*C*+T,, and combinations thereof, wherein + indicates an LNA nucleotide and * indicates a phosphorothioate (PTO) linkage between the nucleotides.