Patent ID: 11873518
Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
Field: Biotechnology (Chemistry)
Classification: CPC C | IPC C

Claim 1:
2. The isolated nucleic acid of claim 1, wherein the recombinant polypeptide comprises a sequence selected from the group consisting of:
(a) about 85% or more identity to SEQ ID NO:2 and has activating mutations at positions 16, 17, 68, 95, 104, 139, 166, 183, 186, 212, 274, 292, 321 and 384;
(b) about 85% or more identity to SEQ ID NO:4 and has activating mutations at positions 29, 30, 80, 107, 116, 151, 178, 195, 198, 224, 285, 303, 332, and 395; and
(c) about 85% or more identity to SEQ ID NO:6 and has activating mutations at positions 18, 19, 69, 96, 105, 140, 167, 184, 187, 213, 274, 292, and 381.