Patent ID: 11912763
Assignee: L & L BIOPHARMA CO., LTD.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 3:
4. A bispecific antibody, comprising a first protein functional region and a second protein functional region, wherein the first protein functional region is the antibody targeting CLDN18.2 as defined in claim 1; and the second protein functional region is an antibody targeting a non-CLDN18.2 antigen, or, the second protein functional region is a cytokine or a cytokine receptor, or a fragment thereof;
the non-CLDN18.2 antigen is an immune checkpoint antigen or a tumor therapeutic target, the immune checkpoint antigen includes PD-1, PD-L1, Tim3, LAG3 and CD47, and the tumor therapeutic target-includes SIRPα; the second protein functional region is an anti-PD-1 antibody, an anti-PD-L1 antibody, an anti-Tim3 antibody, an anti-LAG3 antibody, an anti-CD47 antibody, an anti-CD3 antibody and an anti-CSF-1R antibody.