Patent ID: 11905297
Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 17:
18. The compound of claim 1, wherein the compound has the structure of formula (I):, or a pharmaceutically acceptable salt thereof, wherein:
Y1 and Y2 are each independently N or CR6;
Ar1 and Ar2 are each independently C5-C10 aryl or 5- to 10-membered heteroaryl comprising one, two, or three heteroatoms selected from N, O, and S, each of which are optionally substituted with one or more R10;
R1 is —OH, —C1-C4 alkoxy, —C1-C4 haloalkoxy, —NRaRb, —NRaCOR9, —NRaCO(optionally substituted heterocyclyl), —CONRaRb, —CONRcRd, SO2R12, —O—(C1-C3 alkylene)-O—(C1-C4 alkyl) or —O—(C1-C3 alkylene)-O—(C1-C4 haloalkyl);
R2 is O, NH, or NR11,
R3 is H or methyl;
R4 is H, —CN, —NO2, —CORg, —C1-C4 alkyl, —C1-C4 haloalkyl, or —C3-C4 cycloalkyl;
R5 is H;
R6 is H, halogen, —CN, —NO2, —SCH3, —CORg, —C1-C4 alkyl, —C1-C4 haloalkyl, —C3-C4 cycloalkyl, —C1-C4 alkoxy, or —C1-C4 haloalkoxy;
Ra and Rb are each independently H, —C1-C4 alkyl, —C1-C4 haloalkyl, —CHO, —CO(C1-C3 alkyl), —CO(C1-C6 alkylene)-OH, —CONReRf, —CO(C1-C3 alkylene)-NReRf, —CO(C1-C3 alkylene)-NReSRf, —CO(C1-C3 alkylene)-NReSORg, —CO(C1-C3 alkylene)-NReSO2Rf, —CO(C2-C3 alkenyl), —CO(C1-C3 haloalkyl), —CO(CH2)n(cycloalkyl), —CO(CH2)n(optionally substituted aryl), —CO(CH2)n(optionally substituted heterocyclyl), or —CO(CH2)n(optionally substituted heteroaryl);
Rc and Rd together with the nitrogen atom to which it is attached to form an optionally substituted ring, which can be monocyclic, fused bicyclic, or spiral bicyclic, wherein the ring can contain up to 3 heteroatoms selected from N, O, and S;
Re and Rf are each independently H, —C1-C6 alkyl, —C1-C6 haloalkyl, or —C1-C6 alkylene-OH;
Rg is H, —C1-C6 alkyl, —C3-C6 cycloalkyl, —C1-C6 haloalkyl, phenyl, or benzyl;
R9 is —C1-C3 alkylene-OH, —C1-C3 alkylene-CN, —C1-C3 alkylene-(C1-C3 alkoxy), or —C1-C3 alkylene-NRaRb, —C1-C4 alkyl or —C1-C4 fluoroalkyl;
R10 is halogen, —CN, oxo, —C1-C6 alkyl, —C1-C6 haloalkyl, —C1-C6 alkoxy, —C1-C6 haloalkoxy, —S—S—(C1-C6 alkyl), or optionally substituted phenyl;
R11 is —C1-C4 alkyl, —C1-C4 fluoroalkyl, —C1-C4 alkoxy, or COO(C1-C4 alkyl);
R12 is —OH, —C1-C6 alkyl, —C3-C6 cycloalkyl, —C1-C6 haloalkyl, —C1-C6 alkoxy, phenyl, benzyl, —NRaRb, —CONRaRb, or —NRaCORg;
n is 0, 1, or 2; and
m is 0, 1, or 2.