Patent ID: 11915605
Assignee: nan
Field: Medical technology (Instruments)
Classification: CPC G  A | IPC G

Claim 0:
1. A method of optimizing a composition of a food product based on a ketogenic diet recommended to a human subject with an elevated blood low-density lipoprotein (LDL) level of 100-150 milligrams per deciliter (mg/dL) and at least one of: an elevated blood C-reactive protein level of >3 mg/L and an elevated blood Erythrocyte Sedimentation Rate (ESR) of >20 millimeters per hour (mm/hr), comprising:
under at least one of: design and recommendation of a medical professional,
administering the ketogenic diet for a duration of time of 168±3 days to a population of investigated human subjects with elevated blood LDL levels of 100-150 mg/dL and at least one of:
elevated blood C-reactive protein levels of >3 mg/L and elevated blood ESRs of >20 mm/hr;

performing, through a processor communicatively coupled to a memory, statistical analyses of investigation data of the population of the investigated human subjects based on:
selecting a primary endpoint of the statistical analyses as increasing blood LDL levels and a secondary endpoint of the statistical analyses as concomitantly at least one of: decreasing blood C-reactive protein levels and decreasing blood ESRs for the population of the investigated human subjects;
analyzing the primary endpoint and the secondary endpoint as continuous variables in the statistical arnalyses, and analyzing changes in the primary endpoint and the secondary endpoint based on a Mixed Model for Repeated Measures (WARM) as part of the statistical analyses; and
accounting for at least one of: a subset of the population dropping out of the statistical analyses prior to completion thereof and missing data associated with regard to the primary endpoint and the secondary endpoint by utilizing one of: a Last Observation Carried Forward (LOCF) method and an Intention to Treat (ITT) analysis based on multiple imputation;

determining, through the statistical analyses, that adhering to the ketogenic diet by the population of the investigated human subjects for the duration of time of 168±3 days results in an increase in the elevated blood LDL levels thereof accompanied by at least one of: a decrease in the elevated blood C-reactive protein levels and a decrease in the elevated blood ESRs thereof;
modifying, through the processor, a composition of the ketogenic diet in accordance with the statistical analyses performed based on the determination of the increase in the elevated blood LDL levels of the population of the investigated human subjects accompanied by the at least one of: the decrease in the elevated blood. C-reactive protein levels and the decrease in the elevated blood ESRs thereof; and
modifying the composition of the food product based on the ketogenic diet recommended to the human subject in line with the modified composition of the ketogenic diet.