Patent ID: 11969479
Assignee: THE UNIVERSITY COURT OF THE UNIVERSITY OF GLASGOW
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 1:
2. The nucleic acid molecule of claim 1, wherein the encoded MeCP2 protein comprises:
(i) a methyl-CpG binding domain (MBD) having a sequence, (SEQ ID NO: 5)

PAVPEASASPKQRRSIIRDRGPMYDDPTLPEGWTRKLKQRKSGRSAGKYD

VYLINPQGKAFRSEVELIAYFEKVGDTSLDPNDFDFTVTGRGSPSRREQK

PP,, or a variant thereof having at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity thereto;
(ii) a NCoR/SMRT Interaction Domain (NID) having a sequence, (SEQ ID NO: 6)

PGSVVAAAAAEAKKAVKESSIRSVQETVLPIKKRKTRETV,, or a variant thereof having at least 70%%, at least 75%, at least 80%, at least 85%, at least 90%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity thereto; and
(iii) a nuclear localisation signal (NLS).