Patent ID: 11939307
Assignee: INSTITUTE OF MEDICINAL BIOTECHNOLOGY, CHINESE ACADEMY OF MEDICAL SCIENCES
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC C

Claim 1:
2. The compound as claimed in claim 1 or a pharmaceutically acceptable salt thereof having the structure shown in the formula II:, wherein R1 is alkyl containing 1 to 4 carbons or H;
R2 is H, alkyl, cycloalkyl, aryl, heteroaryl, or, aryl or heteroaryl substituted with 1, 2 or 3 substituents, wherein, the substituent is selected from the group consisting of alkyl, cycloalkyl, alkoxy, phenoxy, alkylthio, phenylthio, halogen, cyano, and haloalkyl; when being alkyl or cycloalkyl, R2 is alkyl containing 1 to 6 carbon atoms, or cycloalkyl containing 3 to 6 carbon atoms, or optionally substituted with halogen;
R3 is cyano or trifluoromethyl;
X is N or CH;
Y is CH;
Z1, Z2, Z3 are the same or different, Z1, Z2, Z3 are each C(R6) or N, respectively, R6 is H, alkyl, cycloalkyl, alkyloxy, phenoxy or substituted phenoxy, alkylthio, phenylthio or substituted phenylthio, haloalkyl, cyano, or halogen;
R4 is, , wherein, n=1-3, R7, R8 are each H, alkyl, or substituted alkyl, respectively, or R7 and R8, together with the nitrogen atom to which they are bonded, form a cyclic group or a substituted cyclic group substituted with 1, 2 or 3 substituents selected from the group consisting of alkyl, alkylamino, dialkylamino, and heterocyclyl, the cyclic group is a three-, four-, five-, six-, or seven-membered saturated or unsaturated cyclic group containing 1 or 2 nitrogen atoms;
or R4 is, wherein R12 is alkyl containing 1-4 carbon atoms;
R11, the nitrogen to which R11 is bound, the carbon to which R10 is bound, the carbon to which R9 is bound, and R9 together form a saturated five-, six-, or seven-membered heterocyclic ring or a saturated five-, six-, or seven-membered heterocyclic ring substituted by 1 or 2 substituents selected from the group consisting of alkyl containing 1 to 4 carbon atoms, alkylamino, and dialkylamino, and akyl in the alkylamino and dialkylamino contains 1 to 4 carbon atoms, R10 is H;
or R11 with the nitrogen to which it is bound, the carbon to which R10 is bound, and R10 together form a saturated five-, six-, or seven-membered heterocyclic ring or a saturated five-, six-, or seven-membered heterocyclic ring substituted by 1 or 2 substituents selected from the group consisting of alkyl containing 1 to 4 carbon atoms, C1-C4 alkylamino, and di-C1-C4 alkylamino, R9 is H;
alternatively, R4 is alkyl which contains 1-4 carbons and is substituted by amino, alkylamino, dialkylamino, or four-, five-, or six membered saturated heterocycles containing one or two nitrogens;
alternatively, R5, R4 and the nitrogen atom to which they are bonded together form a saturated heterocycle or a saturated heterocycle substituted by a substituent, and the heterocycle is a five-, six- or seven-membered heterocycle containing one or two nitrogen atoms, the substituents are selected from the group consisting of alkyl containing 1 to 6 carbon atoms, C1-C4 alkylamino groups, di-C1-C4 alkylamino groups, cycloalkyl groups containing 3 to 5 carbon atoms or saturated heterocyclic groups containing one nitrogen.