Patent ID: 11879019
Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A  G | IPC A  C

Claim 0:
1. An enzyme-responsive peptide, wherein the enzyme-responsive peptide has a general structure of:, , wherein X is selected from O, NH or S; R1 is an enzyme substrate, wherein R1 is a protease substrate selected from the group consisting of a chymotrypsin substrate, a papain substrate, a caspase 8 substrate and a caspase 3 substrate; R2 comprises a reporter molecule or an active ingredient; and R3 is selected from a protecting group, a H, an amino acid or a peptide, wherein the enzyme-responsive peptide requires digestion by two separate enzymes to cleave a bond between the α-carboxylic acid and X—R2 to release R2, wherein the enzyme-responsive peptide requires digestion by a first enzyme selected from the group consisting of chymotrypsin, a papain, caspase 8 and caspase 3 and by a second enzyme, wherein the second enzyme is trypsin.