Patent ID: 11945946
Assignee: ENCAPSYS, LLC
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C  B  F | IPC A  B  C

Claim 17:
18. A method of producing the PU/PBAE microcapsule of claim 1, comprising:
providing a first aqueous solution comprising an emulsifier and water;
providing a second aqueous solution comprising a multifunctional amine, a multifunctional acrylate having an α,β-unsaturated carbonyl, and water, and mixing the second aqueous solution at a first temperature for a first period of time to form a PBAE prepolymer, wherein the PBAE prepolymer is a reaction product of the multifunctional amine and the multifunctional acrylate having the α,β-unsaturated carbonyl, wherein the multifunctional amine adds by aza-Michael addition to a β-carbon atom of the α,β-unsaturated carbonyl;
adding the first aqueous solution into the second aqueous solution under mixing to obtain a mixture of the first aqueous solution and the second aqueous solution;
providing an oil phase comprising the core material and a polyisocyanate;
adding the oil phase into the mixture of the first aqueous solution and the second aqueous solution, applying high shear agitation at a second temperature until a target particle size is reached to obtain an emulsion; and
increasing a temperature to a third temperature in a second period of time and holding the temperature at the third temperature for a third period of time under mixing.