Patent ID: 11897919
Assignee: GEOVAX, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 0:
1. A method for inducing an immune response to a human immunodeficiency virus (HIV) comprising administering to a human in need thereof:
i) a prime vaccination comprising an effective amount of a DNA vector encoding Gag-Pol and Env and one or more of Tat, Rev, Nef, Vif, Vpr, or Vpu HIV-1 antigens that, when expressed, are displayed on virus-like particles (VLPs); and
ii) a boost vaccination comprising
a) an effective amount of a first modified vaccinia Ankara (MVA) vector encoding a membrane-bound HIV-1 envelope (Env) protein that, when expressed, is displayed on VLPs, and,
b) an effective amount of a second MVA vector encoding an HIV-1 gp-140 protein.