Patent ID: 11872074
Assignee: nan
Field: Medical technology (Instruments)
Classification: CPC A | IPC A

Claim 19:
20. A system for non-invasive monitoring of an intracranial reserve space (ICRS) parameter of a mammalian subject, comprising:
a multi-frequency ultrasound probe configured, beginning at a start time, to emit and receive ultrasound waves into and from a head of the subject and to produce a signal of brain tissue pulsation;
an instrument configured to non-invasively apply a pressure to a neck of the subject to effectuate a partial occlusion of a cross-section of an internal jugular vein of the subject, the partial occlusion starting at the start time, the instrument including a second ultrasound probe configured to produce a second signal for imaging a cross-section of the internal jugular vein, the second ultrasound probe having a Doppler ultrasound output for measuring a linear velocity of venous blood at the internal jugular vein, the instrument including a pressure applying component having at least one surface configured to contact the neck and including a manometer; and
a computer system configured to receive the signal and an output of the start time of the partial occlusion of the internal jugular vein of the subject, the computer system also configured to receive the second signal and to derive from the second signal an image of the cross-section of the internal jugular vein and to determine the linear velocity of venous blood at the internal jugular vein, the computer system also configured, using one or more processors, to derive from the signal an intracranial brain tissue pulsation waveform, and to determine an ICRS capacity from (i) a length of time (T) from the start time to a subsequent time at which the waveform is compressed so as to exhibit a predefined decline in variability, the predefined variability being an amount that is 5% or more, and from (ii) a volume velocity (V) of blocked venous blood output occluded at the IJV, wherein the volume velocity is determined by the computer system from the linear velocity of the internal jugular vein derived from the Doppler ultrasound output and from the image of the cross-section of the internal jugular vein.