Patent ID: 11891413
Assignee: IDORSIA PHARMACEUTICALS LTD
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A  G | IPC A  C  G

Claim 14:
15. A conjugate of general formula (IV)

[T*-((—Ux+4—Ux+3—Ux+2—Ux+1—Ux)m—(Vx+2—Vx+1—Vx)1-m)n-T-O-L-E1-W]c-CP  (IV)

wherein
m is an integer selected from 0 and 1;
x is 1;
n is an integer selected from 2, 3, 4, 5, 6, 7, and 8;, T*- represents H—;
-L- represents -La-, -La-Le-, -La-Lb-Le-, or -La-Ld-Le-;
-La- represents —(CH2)o—, —(CH2—CH2—O)o—C2H4—, or —(CH2—CH2—O)o—CH2;
-Lb- represents —O—, —NH—CO—NH—, —NH—CO—CH2—NH—, —NH—CO—;
-Ld- represents —(CH2)q—, —(CH(OH))q—, —(CF2)q—, —(CH2—CH2—O)q—C2H4—, or —(CH2—CH2—O)q—CH2—;
-Le- represents —(CH2)p1—, —(CF2)p1—, —C2H4—(O—CH2—CH2)p1—, —CH2—(O—CH2—CH2)p1— or —(CH2)p1—O—(CH2)p2—; and
o, q, p1 and p2 are independently of each other an integer selected from 1, 2, 3, 4, 5, and 6;
T represents a bond;
c is comprised between 2 and 18;
-E1- represents a covalent bond, —NH—, —O—NH—, —O—, —S—, —CO—, —CH═CH—, —CONH—, —CO—NHNH—,, —W— is selected from:, a represents an integer selected from 1, 2, 3, 4, 5, 6, 7, 8, 9 and 10,
b represents an integer selected from 1, 2, 3 and 4; and
CP is a carrier protein selected from the group consisting of: a diphtheria toxoid, a mutated diphtheria toxoid, a modified diphtheria toxoid, a mutated and modified diphtheria toxoid, a tetanus toxoid, a modified tetanus toxoid, a mutated tetanus toxoid, non-lipidated cell-surface liporotein (protein D) of non-typeable Haemophilus influenzae, outer membrane protein (OMP) complex of Neisseria meningitidis, bovine serum albumin (BSA), keyhole limpet hemocyanine (KLH), recombinant non-toxic form of Pseudomonas aeruginosa exotoxin A (rEPA) or cholera toxoid (CT).