Patent ID: 11906454
Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Field: Measurement (Instruments)
Classification: CPC G  B | IPC B  G

Claim 0:
1. A device for quantitatively measuring the metabolic rate of a single cell comprising:
a highly sensitive thermopile-based microcalorimetric sensor further comprising a plurality of individual sensor elements, wherein each individual sensor element comprises a membrane and a combination of at least one heating element and at least one thermopile disposed on the same membrane,
wherein the thermopile is fabricated of a material selected from a combination of a first alloy of Copper and Nickel and a second alloy of Nickel and Chrome, or a combination of the first alloy and a third alloy of Nickel and Chrome, the thermopile-based microcalorimetric sensor provides sub nano-Watt resolution, and the sub nano-Watt resolution measures energy production and consumption in the single cell in real time.