Patent ID: 11873307
Assignee: NOVARTIS AG
Field: Organic fine chemistry (Chemistry)
Classification: CPC C  A  Y | IPC C

Claim 7:
8. The method of claim 2, wherein the compound of formula IV is a compound of formula XIII*:, , wherein R1 is a secondary amino protecting group and *R2 is an acylated amino group;
wherein the compound of formula XIII* is obtained by hydrogenating a compound of formula VIII*:, , wherein R1 is a secondary amino protecting group and *R2 is an acylated amino group; in the presence of a chiral hydrogenation catalyst to yield a compound of formula X*:, , wherein R1 is a secondary amino protecting group and *R2 is an acylated amino group;
reducing the compound of formula X* to yield a compound of formula XI*:, , wherein R1 is a secondary amino protecting group and *R2 is an acylated amino group;
reacting the compound of formula XI* with a leaving group forming agent of the formula LG*-X wherein LG* is an electrophilic radical capable of forming, with a hydroxy to which it is bound, a leaving group LG2, and X is halogen, to yield a compound of formula XII*:, , wherein R1 is a secondary amino protecting group, *R2 is an acylated amino group, and LG2 is a leaving group; and
cyclizing the compound of formula XII* under basic conditions to yield the compound of formula XIII*.