Patent ID: 11872277
Assignee: THE SCRIPPS RESEARCH INSTITUTE
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 27:
28. The polynucleotide of claim 26, wherein the fusion polypeptide comprises from N terminus to C terminus (a) the engineered Ebolavirus GP protein, linker sequence G4S (SEQ ID NO:43), nanoparticle sequence ferritin, (b) the engineered Ebolavirus GP protein, linker sequence G4S (SEQ ID NO:43), nanoparticle sequence E2p, or (c) the engineered Ebolavirus GP protein, linker sequence (G4S)2 (SEQ ID NO:42), nanoparticle sequence I3-01v9; wherein the engineered Ebolavirus GP protein comprises W615L substitution, proline substitution T577P, and HR2 extension from residue 632 to residue 637 in MPER.