Patent ID: 11891661
Assignee: ROCHE SEQUENCING SOLUTIONS, INC.
Field: Measurement (Instruments)
Classification: CPC C  G | IPC C  G

Claim 8:
9. A system for detecting whether a membrane has thinned in a cell of a nanopore based sequencing chip, comprising:
a capacitor;
a working electrode electrically coupled to the capacitor;
a counter electrode;
a surface configured to support a membrane between the working electrode and the counter electrode such that the membrane is electrically coupled with the capacitor;
a voltage source configured to apply a first voltage to the counter electrode;
an analog measurement circuitry configured to periodically sample a second voltage across the capacitor; and
a processor or a circuitry configured to:
determine a change in the sampled second voltage across the capacitor in response to a change in the first voltage; and
detect whether the membrane has been thinned at least partly into the thin membrane based on the determined change in the sampled second voltage across the capacitor in response to the change in the first voltage.