Patent ID: 11960072
Assignee: INSCOPIX, INC.
Field: Computer technology (Electrical engineering)
Classification: CPC G | IPC G

Claim 26:
27. A system configured to effectuate multi-modal imaging, the system comprising:
an adapter comprising (i) a first microscope interface configured to optically couple a first microscope to an optical element that is in optical communication with an optical probe to provide functional imaging data of a sample, and (ii) a second microscope interface configured to optically couple a second microscope to the optical element to provide structural imaging data of the sample; and
a processor configured
(i) to process the functional imaging data, received from the adapter, to generate a first overlaid image,
(ii) to process the structural imaging data, received from the adapter, to generate a second overlaid image,
(iii) to co-register the first overlaid image and the second overlaid image with the use of aligning at least a portion of the first overlaid image and the second overlaid image based at least in part on a coordinate transformation,
wherein the coordinate transformation is derived based at least in part on a difference in sizes, shapes, positions, or orientations of a landmark feature present both in the first overlaid image and the second overlaid image;

(iv) to use the difference in sizes, shapes, positions, or orientations of the landmark feature in the first overlaid image and in the second overlaid image to characterize an amount of distortion or warping of the landmark feature between the first overlaid image and the second overlaid image; and
(v) to generate a third overlaid image from the first overlaid image and the second overlaid image after said co-registering.