Patent ID: 11957647
Assignee: OREXO AB
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 19:
20. A nasal applicator device suitable and/or adapted for delivery of a pharmaceutically-acceptable composition to the nose, which composition is in the form of a spray-dried powder with a particle size distribution that comprises a D10 above about 10 μm and a D90 below about 100 μm, which composition comprises a mixture of:
(a) epinephrine (adrenaline) or a pharmaceutically-acceptable salt thereof in a dosage amount of between about 0.5 and about 2 mg when calculated as the free base;
(b) a pharmaceutically-acceptable carrier material, which carrier material comprises a combination of trehalose and maltodextrin 19DE, in a ratio of between about 3:1 and 1:3 by weight;
(c) about 0.75% to about 3% by weight of sucrose monolaurate; and
(d) less than about 5% of water; and, which nasal applicator device:
(i) comprises, or is adjunct and/or attached to, a reservoir, within which reservoir said composition is contained; and
(ii) is configured such that said device, upon actuation, is capable of depositing an effective dose of epinephrine, or salt thereof, to the nasal mucosa.