Patent ID: 11903638
Assignee: BIOSENSE WEBSTER (ISRAEL) LTD.
Field: Medical technology (Instruments)
Classification: CPC A | IPC A

Claim 0:
1. A medical apparatus for regulating delivery of irreversible electroporation (IRE) pulses, the medical apparatus comprising:
a probe configured for insertion into a body of a patient and comprising a plurality of electrodes configured to contact tissue within the body;
an electrical signal generator configured to apply bipolar trains of pulses between at least one pair of the plurality of electrodes, each bipolar pulse having a voltage amplitude of at least 200 V and a duration less than 20 μs between at least one pair of the plurality of electrodes in contact with the tissue, thereby causing IRE of the tissue between the at least one pair of the electrodes;
one or more electrical sensors coupled to an output of the electrical signal generator and configured to measure a voltage and a current flowing between the at least one pair of the plurality of electrodes in a sequence of time intervals; and
a controller configured to:
i) measure a dissipated electrical energy between the at least one pair of the electrodes from the bipolar trains of pulses, which is to be transferred to the tissue during trains of the bipolar trains of pulses, by computing a sum of a product of the voltage and the current flowing between the at least one pair of electrodes over the sequence of the time intervals, the voltage and current being measured by the one or more electrical sensors;
ii) determine, based on IRE setup parameters, a target value of the dissipated electrical energy to be transferred to the tissue from the bipolar trains of pulses applied to the tissue in contact with the at least one pair of electrodes;
iii) cause electrical and temporal parameters of the bipolar trains of pulses to be transmitted to the electrical signal generator;
iv) determine, continuously, whether the measured dissipated electrical energy that is to be transferred to the tissue in contact with the least one pair of electrodes during IRE is equal to or exceeds the target value;
v) cause the IRE to be terminated when the measured dissipated electrical energy that is transferred to the tissue is equal to or exceeds the target value;
vi) determine, when the measured dissipated energy that is to be transferred to the tissue is less than the target value, a predicted total dissipated electrical energy to be transferred to the tissue based upon the electrical and temporal parameters;
vii) compare the predicted total dissipated electrical energy to the target value;
viii) cause the electrical and temporal parameters to be modified when the predicted total dissipated energy is less than the target value; and
ix) cause the IRE to be terminated when the measured dissipated electrical energy that is to be transferred to the tissue equals the target value.