Patent ID: 11884721
Assignee: ÉCOLE POLYTECHNIQUE FÉDÉRALE DE LAUSANNE
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A  B | IPC A  B  C

Claim 0:
1. A method for inducing antigen-specific tolerance to an antigen in a subject, the method comprising:
administering a composition to a subject in an amount effective to induce antigen-specific tolerance, the composition comprising:
i) an erythrocyte-binding moiety, wherein the erythrocyte-binding moiety has the ability to non-covalently, specifically bind an exterior erythrocyte surface in situ in blood, wherein the erythrocyte-binding moiety comprises an antibody fragment directed against glycophorin A, and
ii) an antigen to which tolerance is desired, wherein the antigen is selected from a portion of myelin basic protein, a portion of myelin oligodendrocyte glycoprotein, a portion of proteolipid protein, myelin basic protein, myelin oligodendrocyte glycoprotein, proteolipid protein, and combinations thereof;
wherein the antigen to which tolerance is desired is recombinantly fused to the erythrocyte-binding moiety, and
wherein, upon administration to a human in which tolerance to the antigen is desired, the composition binds to CD45 negative cells, but not to CD45 positive cells, and the composition reduces, fails to induce, or prevents inflammatory responses in antigen-specific T cells as compared to when the human is exposed to the antigen.