Patent ID: 11939397
Assignee: NOVARTIS AG
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 14:
15. The method of claim 12, wherein the at least one additional therapeutic agent is an A2AR antagonist, wherein the A2AR antagonist is selected from:
i. an anti-CD73 antibody molecule, or antigen-binding fragment thereof, optionally wherein the anti-CD73 antibody is selected from:
a. an anti-CD73 antibody molecule comprising a heavy chain variable region comprising the amino acid sequence of SEQ ID NO: 295 and a light chain variable region comprising the amino acid sequence of SEQ ID NO: 296, or an amino acid sequence at least 85%, 90%, 95% identical or higher to SEQ ID NO: 295 or 296;
b. an anti-CD73 antibody molecule comprising a heavy chain variable region comprising the amino acid sequence of SEQ ID NO: 299 and a light chain variable region comprising the amino acid sequence of SEQ ID NO: 300, or an amino acid sequence at least 85%, 90%, 95% identical or higher to SEQ ID NO: 299 or 300;
c. an anti-CD73 antibody molecule comprising a heavy chain variable region comprising the amino acid sequence of SEQ ID NO: 302 and a light chain variable region comprising the amino acid sequence of SEQ ID NO: 303, or an amino acid sequence at least 85%, 90%, 95% identical or higher to SEQ ID NO: 302 or 303;
d. an anti-CD73 antibody molecule comprising a heavy chain variable region comprising the amino acid sequence of SEQ ID NO: 304 and a light chain variable region comprising the amino acid sequence of SEQ ID NO: 305, or an amino acid sequence at least 85%, 90%, 95% identical or higher to SEQ ID NO: 304 or 305;
e. an anti-CD73 antibody molecule comprising a heavy chain variable region comprising the amino acid sequence of SEQ ID NO: 306 and a light chain variable region comprising the amino acid sequence of SEQ ID NO: 307, or an amino acid sequence at least 85%, 90%, 95% identical or higher to SEQ ID NO: 306 or 307; or
f. an anti-CD73 antibody molecule comprising a heavy chain variable region comprising the amino acid sequence of SEQ ID NO: 308 and a light chain variable region comprising the amino acid sequence of SEQ ID NO: 309, or an amino acid sequence at least 85%, 90%, 95% identical or higher to SEQ ID NO: 308 or 309; or
ii. PBF509/NIR178, CPI444/V81444, AZD4635/HTL-1071, Vipadenant, GBV-2034, AB928, Theophylline, Istradefylline, Tozadenant/SYN-115, KW-6356, ST-4206, and Preladenant/SCH 420814; or
iii. 5-bromo-2,6-di-(1H-pyrazol-1-yl)pyrimidine-4-amine, or a pharmaceutically acceptable salt thereof; (S)-7-(5-methylfuran-2-yl)-34(6-(((tetrahydrofuran-3-yl)oxy)methyl)pyridin-2-yl)methyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-amine, or a pharmaceutically acceptable salt thereof; (R)-7-(5-methylfuran-2-yl)-3-((6-(((tetrahydrofuran-3-yl)oxy)methyl)pyridin-2-yl)methyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-amine, or racemate thereof, or a pharmaceutically acceptable salt thereof; 7-(5-methylfuran-2-yl)-3-((6-(((tetrahydrofuran-3-yl)oxy)methyl)pyridin-2-yl)methyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-amine, or a pharmaceutically acceptable salt thereof; and 6-(2-chloro-6-methylpyridin-4-yl)-5-(4-fluorophenyl)-1,2,4-triazin-3-amine, or a pharmaceutically acceptable salt thereof.