Patent ID: 11938127
Assignee: WAYNE STATE UNIVERSITY
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 19:
20. A method of synthesizing a 4-quinolone compound, comprising:
contacting a flavone with a strong acid in a ratio of molar equivalents in the range of 1:2 to 1:100 in a closed system at a temperature in the range of 0° C. to 60° C. for a time period in the range of 2 hours to 10 days, producing a precipitate containing a corresponding flavylium salt;
reacting the flavylium salt with an amine, wherein the flavylium salt and amine are present a ratio of molar equivalents in the range of 1:3 to 1:5, in an aprotic solvent for a second time period in the range of 2 hours to 2 days, producing a mixture comprising a 4-quinolone compound in the aprotic solvent; and
purifying the 4-quinolone compound from the mixture.