Patent ID: 11903963
Assignee: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C  B  Y | IPC A  C

Claim 23:
24. A synthetic heparin analogue produced by the method of claim 15, wherein the synthetic heparin analogue has anti-Xa activity ranging from about 10 ngml−1 to about 40 ngml−1 IC50 and comprises disaccharide units of a glucuronic acid (GlcA) residue linked to a glucosamine (GlcN) residue modified by sulfation and an iduronic acid (IdoA) residue linked to a GlcN) residue modified by sulfation, comprising:
a 3-O-sulfated oligosaccharide comprising six to eight saccharide units;
at least one disaccharide unit sulfated by a 3-OST-3 enzyme;
at least one IdoA2S-GlcNS3 S or at least one IdoA2S-GlcNS3 S6S disaccharide unit, and is devoid of a GlcA-GlcNS3S6S disaccharide unit; and, at least one disaccharide unit comprising a GlcNS6S residue.