Patent ID: 11899022
Assignee: THE GENERAL HOSPITAL CORPORATION
Field: Measurement (Instruments)
Classification: CPC G  H | IPC G  H

Claim 18:
19. The method of claim 11, wherein performing mass spectral analysis of each of the biological samples comprises:
ionizing peptides derived from the biological samples to generate peptide ions;
fragmenting a first portion of the peptide ions by collision-induced dissociation to generate a first population of peptide ion fragments;
fragmenting a second portion of the peptide ions by high-energy collision dissociation in an orbital trap to generate a second population of peptide ion fragments;
analyzing the first population of peptide ion fragments by trapping the first population of peptide ion fragments in a linear ion trap to identify a first population of peptides corresponding to the first population of peptide ion fragments;
analyzing the second population of peptide ion fragments in an orbital trap to identify a second population of peptides corresponding to the second population of peptide ion fragments; and
identifying a set of proteins expressed in the biological sample based on the first and second populations of peptides.