Patent ID: 11919885
Assignee: KING FAISAL UNIVERSITY
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 4:
5. A method of making the 4-(4-bromophenyl)-2-alkyloxy-6-(2-oxo-2H-1-benzopyran-3-yl)pyridine-3-carbonitrile compound of claim 1, the method comprising:
adding a mixture of 3-acetyl-2H-1-benzopyran-2-one and 4-bromobenzaldehyde to a solution of a sodium alkoxide in an absolute alcohol with stirring to obtain a first reaction mixture;
adding malononitrile to the first reaction mixture to obtain a second reaction mixture;
irradiating the second reaction mixture followed by cooling to room temperature to obtain a solid precipitate;
purifying the solid precipitate by filtering and recrystallization using the absolute alcohol; and
obtaining the 4-(4-bromophenyl)-2-alkyloxy-6-(2-oxo-2H-1-benzopyran-3-yl)pyridine-3-carbonitrile compound.