Patent ID: 11872307
Assignee: PATHEON SOFTGELS INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 0:
1. An oral pharmaceutical composition suitable for chewing, sucking, or buccal dissolution comprising a soft shell encapsulating a liquid matrix, the shell consists of:
(a) about 20% to about 50% by weight of the shell of one or more of gelatin, partially hydrolyzed gelatin, or hydrolyzed gelatin;
(b) about 30% to about 50% by weight of the shell of glycerol, maltitol, mannitol, xylitol, lycasin, or combinations thereof;
(c) about 0.25% to about 1% by weight of the shell of citric acid, acetic acid, lactic acid, malic acid, tartaric acid, or combinations thereof;
(d) about 0.1% to about 5% by weight of the shell of sucralose, aspartame, stevia, acesulfame potassium, xylitol, or combinations thereof; and
(e) about 10% to about 40% water by weight of the shell; and, the liquid matrix consists of:
(f) about 20% to about 90% by weight of the matrix of polypropylene glycol, polyethylene glycol 400, polyvinylpyrrolidone, gylcerol, sorbitol, maltitol, xylitol, maltitol, or combinations thereof;
(g) about 0.1% to about 10% by weight of the matrix of thaumatin, glycyrrhizic acid salts, acesulfame potassium, acesulfame salts, sucralose, aspartame, stevia, or combinations thereof;
(h) about 0.01% to about 5% by weight of the matrix of citric acid, lactic acid, sodium citrate, orange flavor, cherry flavor, eucalyptol, peppermint oil, methyl salicylate, glycine, or combinations thereof;
(i) about 1% to about 15% water by weight of the matrix; and
(j) about 0.25% to about 50% by weight of the matrix of one or more active pharmaceutical ingredients.