Patent ID: 11884732
Assignee: DRAGONFLY THERAPEUTICS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 10:
11. The protein according to claim 9, wherein the first and second antibody Fc domains each comprise an amino acid sequence at least 90% identical to the Fc domain of human IgG1, and the amino acid mutations to promote heterodimerization comprise one or more mutations at Q347, Y349, T350, L351, S354, E356, E357, K360, Q362, S364, T366, L368, K370, N390, K392, T394, D399, S400, D401, F405, Y407, K409, T411, and/or K439, numbered according to the EU index as in Kabat.