Patent ID: 11964051
Assignee: TRANSLATE BIO, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 9:
10. A cationic lipid having a structure according to Formula (I′),, , wherein
RX is independently —H;
each of L2 and L3 is independently a covalent bond, —C(O)—, or —C(O)O—;
L4A is independently —C(O)—, —C(O)O—, or —C(O)NRL;
L4B is independently unsubstituted C2-C20 alkylene; unsubstituted C2-C20 alkenylene; or unsubstituted C2-C20 alkynylene;
B is NR4R5, a 5- to 10-membered nitrogen-containing heterocyclyl, or a 5- to 10-membered nitrogen-containing heteroaryl;
each R2 and R3 is independently C6-C30 alkyl, C6-C30 alkenyl, or C6-C30 alkynyl;
each R4 and R5 is independently hydrogen, C1-C10 alkyl; C2-C10 alkenyl; or C2-C10 alkynyl; or R4 and R5 combine to form a 5- to 10-membered heterocyclyl or a 5- to 10-membered heteroaryl;
each RL is independently hydrogen, C1-C20 alkyl, C2-C20 alkenyl, or C2-C20 alkynyl.