Patent ID: 11904057
Assignee: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  B | IPC A  B

Claim 8:
9. A peptide hydrogel, comprising:
nanoparticles encapsulated within the peptide hydrogel, wherein the nanoparticles comprise a nucleic acid molecule complexed with a first amphiphilic cationic β-hairpin peptide that is unfolded and not in a β-hairpin conformation, and wherein:
the peptide hydrogel is formed from a fibrillar network of a second amphiphilic cationic β-hairpin peptide that is in a β-hairpin conformation;
the first amphiphilic cationic β-hairpin peptide comprises or consists of an amino acid sequence set forth as: VKVKVKVKVDPPTKVKVKVKV-NH2; and
the second amphiphilic cationic β-hairpin peptide comprises or consists of an amino acid sequence set forth as: VLTKVKTKVDPPTKVEVKVLV-NH2.