Patent ID: 11915833
Assignee: B.G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD., AT BEN-GURION UNIVERSITY
Field: Medical technology (Instruments)
Classification: CPC G | IPC G

Claim 17:
18. A system for predicting a disease state and/or progression rate, the system comprising:
an input device operative to receive feature-based representation of a first plurality of patients, the feature-based representation including static and dynamic features;
a computing device configured to:
assign a second plurality of plurality of patients among a plurality of patient clusters, each of the plurality of second patients represented with said static and dynamic features,
train a cluster-specific classifier for each of the plurality of patient clusters, each respective cluster-specific classifier operative to predict a disease state for a portion of the second plurality of patients of a respective one of the plurality of associated patient clusters;
iteratively run a training cycle until a performance measure is achieved, the training cycle including:
predicting disease states for the portion of the second plurality of patients with each of the respective cluster-specific classifiers,
reassigning at least one of the plurality of second patients to a different one of the plurality of patient clusters, wherein the respective cluster-specific classifier of the different patient cluster predicts a disease state and/or progression rate best matching a true disease state and/or a progression rate of said at least one of the plurality of second patients, and
retraining each of the respective cluster-specific classifiers using patients associated with each of the plurality of patient clusters after the reassigning;

receive feature-based representations of a new patient;
assign the new patient to a particular one of the plurality of patient clusters based on the received feature-based representations of the new patient; and
use the retrained cluster-specific classifier of the particular patient cluster to predict a disease state and/or progression rate of the new patient; and

an output device operative to output the disease state and/or progression rate.