Patent ID: 11946064
Assignee: THE BRIGHAM AND WOMEN'S HOSPITAL
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 22:
23. The composition of claim 1, wherein the microRNA cluster comprises:
(a) a miR-128 5′ flanking sequence, a miR-128 hairpin domain, a first miR-17-92 spacer sequence, a miR-124 hairpin domain, a second miR-17-92 spacer sequence, a miR-137 hairpin domain, and a miR-128 3′ flanking sequence;
(b) a 5′ flanking sequence comprising a microRNA sponge sequence that is fully or partially antisense to a miR-21 target sequence, a miR-128 hairpin domain, a first spacer sequence encoding an aptamer that binds to a p50 protein, a miR-124 hairpin domain, a second spacer sequence comprising a miR-17-92 spacer sequence, a miR-137 hairpin domain, and a miR-128 3′ flanking sequence; or
(c) a miR-128 5′ flanking sequence, a miR-128 hairpin domain, a first miR-17-92 spacer sequence, a miR-124 hairpin domain, a second miR-17-92 spacer sequence, a miR-137 hairpin domain, a third miR-17-92 spacer sequence, a miR-7 hairpin domain, a fourth miR-17-92 spacer sequence, a miR-218 domain, a fifth miR-17-92 spacer sequence, a miR-34 hairpin domain, and a miR-128 3′ flanking sequence.