Patent ID: 11897955
Assignee: ACROIMMUNE BIOTECH CO., LTD.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A  Y | IPC A  C

Claim 1:
2. The monoclonal antibody or the derivative thereof according to claim 1, wherein the monoclonal antibody or the derivative thereof has one or more of the following characteristics:
a) comprising the antibody light chain variable region and the antibody heavy chain variable region, an amino acid sequence of the antibody light chain variable region is at least 90% identical to an amino acid sequence shown in SEQ ID NO: 17; and an amino acid sequence of the antibody heavy chain variable region is at least 90% identical to an amino acid sequence shown in SEQ ID NO: 19;
b) a constant value of a binding affinity with a human TIGIT antigen is equal to or less than 10 nM;
c) antagonistically inhibiting a binding of the TIGIT antigen to its ligand, CD155 (PVR).