Patent ID: 11959906
Assignee: OXFORD NANOPORE TECHNOLOGIES PLC
Field: Measurement (Instruments)
Classification: CPC G  B  C | IPC B  C  G

Claim 24:
25. An analysis device, comprising:
a measurement system configured to make electrical measurements of a polymer during translocation of a polymer through a nanopore to generate a time-ordered series of electrical measurements, wherein the polymer is a polynucleotide comprising at least 1,000 nucleotide pairs, wherein the translocation is controlled by an enzyme molecular motor and wherein each of the electrical measurements is an electrical measurement of respective k polymer units of the polymer, where k is 3 or greater;
at least one processor configured to perform:
deriving, from the time-ordered series of electrical measurements, a feature vector of time-ordered features representing characteristics of the time-ordered series of electrical measurements, wherein the features comprise: an average of the electrical measurements, a period of the electrical measurements, a variance of the electrical measurements, asymmetry information, confidence information of the electrical measurements, and a distribution of the electrical measurements, wherein the feature vector comprises at least 1000 sets of time-ordered features;
analyzing the feature vector that comprises the at least 1000 sets of time-ordered features and at least one other feature vector indicative of a target polymer by using an alignment algorithm or a machine learning technique; and
estimating an identity of the target polymer using results of analyzing the feature vector comprising the at least 1000 sets of time-ordered features and the at least one other feature vector indicative of the target polymer.