Patent ID: 11883541
Assignee: THE JOHNS HOPKINS UNIVERSITY
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  B | IPC A  B

Claim 0:
1. A method for treating a disease or condition of the eye, the method comprising non-virally transfecting one or more cells in a suprachoroidal space by administering to a suprachoroidal space of an eye of a subject a composition comprising a nanoparticle or a microparticle comprising a poly(beta-amino ester) (PBAE) and a therapeutic agent, wherein the therapeutic agent is selected from an expression construct, a therapeutic transgene, a therapeutic protein, a viral vector, a plasmid, a gene, a nucleic acid, DNA, RNA, and mRNA, and wherein the PBAE is, wherein:
n is an integer from 1 to 10,000;
R1, R2, R3, R4, R5, R6, R7, R8, and R9 are each hydrogen;
R1 is absent and when present the compound of formula (I) further comprises a counter ion selected from the group consisting of chloride, fluoride, bromide, iodide, sulfate, nitrate, fumarate, acetate, carbonate, stearate, laurate, and oleate; and,