Patent ID: 11958042
Assignee: UMICORE AG & CO. KG
Field: Organic fine chemistry (Chemistry)
Classification: CPC B  C | IPC B  C

Claim 0:
1. A method for synthesizing a musk macrocycle, represented by Formula (K), the method comprising:
a) contacting an olefin represented by Formula (G), with at least one metathesis reaction partner represented by Formula (H), in the presence of at least one Group 8 metal olefin metathesis catalyst under conditions sufficient to form a metathesis product, wherein the at least one metathesis catalyst is represented by the structure of Formula (4):, wherein:
R1m is H or methyl;
OR2m is a protected hydroxyl group;
R3m is branched or straight C1-C5 alkyl;
x is 2, 3, 4 or 5;
y is 5, 6, 7, or 8;
M is a Group 8 transition metal;
L2 is a neutral electron donor ligand;
n is 0 or 1;
Ra is hydrogen, unsubstituted hydrocarbyl, substituted hydrocarbyl, unsubstituted heteroatom-containing hydrocarbyl, or substituted heteroatom-containing hydrocarbyl;
Rb is hydrogen, unsubstituted hydrocarbyl, substituted hydrocarbyl, unsubstituted heteroatom-containing hydrocarbyl, or substituted heteroatom-containing hydrocarbyl; or Ra and Rb are linked together to form a five or a six-heterocyclic membered ring with the sulfoxide group;
X1 and X2 are independently anionic ligands;

R1 and R2 are independently hydrogen, unsubstituted hydrocarbyl, substituted hydrocarbyl, unsubstituted heteroatom-containing hydrocarbyl, or substituted heteroatom-containing hydrocarbyl; or R1 and R2 are linked together to form an optionally substituted indenylidene;
X5 and Y5 are independently C, CR3A or N; and only one of X5 or Y5 can be C or CR3A;
R3A is hydrogen, unsubstituted hydrocarbyl, substituted hydrocarbyl, unsubstituted heteroatom-containing hydrocarbyl, or substituted heteroatom-containing hydrocarbyl;
Q is a two-atom linkage having the structure or —[CR11R12]s—[CR13R14]t— or —[CR11═CR13]—;
R11, R12, R13 and R14 are independently hydrogen, unsubstituted hydrocarbyl, substituted hydrocarbyl, unsubstituted heteroatom-containing hydrocarbyl, or substituted heteroatom-containing hydrocarbyl;
“s” and “t” are independently 1 or 2;
R3 is unsubstituted hydrocarbyl, substituted hydrocarbyl, unsubstituted heteroatom-containing hydrocarbyl, or substituted heteroatom-containing hydrocarbyl; and
R4 is unsubstituted hydrocarbyl, substituted hydrocarbyl, unsubstituted heteroatom-containing hydrocarbyl, or substituted heteroatom-containing hydrocarbyl.