Patent ID: 11939319
Assignee: UCB PHARMA GMBH
Field: Organic fine chemistry (Chemistry)
Classification: CPC C  A | IPC C

Claim 21:
22. A compound selected from
6-chloro-N-[6-(2,2-difluoroethoxy)-2,5-difluoropyridin-3-yl]-1H-indole-3-sulfonamide;
N-[6-(difluoromethoxy)-5-fluoro-2-methoxypyridin-3-yl]-1H-pyrrolo[3,2-h]quinoline-3-sulfonamide;
N-[6-(2,2-difluoroethoxy)-5-fluoro-2-methoxypyridin-3-yl]-1H-pyrrolo[3,2-h]quinoline-3-sulfonamide;
5-bromo-6-chloro-N-[6-(2,2-difluoroethoxy)-5-fluoro-2-methoxypyridin-3-yl]-1H-pyrrolo[2,3-b]pyridine-3-sulfonamide;
6-chloro-N-[6-(2,2-difluoroethoxy)-5-fluoro-2-methoxypyridin-3-yl]-7-fluoro-1H-indole-3-sulfonamide;
6-cyano-N-[6-(2,2-difluoroethoxy)-5-fluoro-2-methoxypyridin-3-yl]-1H-indole-3-sulfonamide;
N-[6-(2,2-difluoroethoxy)-5-fluoro-2-methoxypyridin-3-yl]-6-(difluoromethoxy)-1H-indole-3-sulfonamide;
N-[6-[2-(difluoromethoxy)ethoxy]-5-fluoro-2-methoxypyridin-3-yl]-6-(difluoromethyl)-1H-pyrrolo[2,3-b]pyridine-3-sulfonamide;
6-chloro-N-[6-[2-(difluoromethoxy)ethoxy]-5-fluoro-2-methoxypyridin-3-yl]-1H-pyrrolo[2,3-b]pyridine-3-sulfonamide;
N-[6-(2,2-difluoroethoxy)-5-fluoro-2-methoxypyridin-3-yl]-6-(difluoromethyl)-1H-indole-3-sulfonamide;
6-chloro-N-(6-cyclopropyl-5-fluoro-2-methoxypyridin-3-yl)-1H-indole-3-sulfonamide;
6-chloro-N-(5-fluoro-2-methoxypyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine-3-sulfonamide;
N-[6-(difluoromethoxy)-5-fluoro-2-methoxypyridin-3-yl]-6-methoxy-1H-indole-3-sulfonamide;
N-[6-(2,2-difluoroethoxy)-5-fluoro-2-methoxypyridin-3-yl]-6-methoxy-1H-indole-3-sulfonamide;
6-chloro-N-[6-[2-(difluoromethoxy)ethoxy]-5-fluoro-2-methoxypyridin-3-yl]-1H-indole-3-sulfonamide;
N-[6-(difluoromethoxy)-5-fluoro-2-methoxypyridin-3-yl]-6-methyl-1H-indole-3-sulfonamide;
6-cyano-N-[6-(difluoromethoxy)-5-fluoro-2-methoxypyridin-3-yl]-1H-indole-3-sulfonamide;
6-(difluoromethyl)-N-(2,5-difluoro-6-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine-3-sulfonamide;
6-(difluoromethyl)-N-(5-fluoro-2,6-dimethoxypyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine-3-sulfonamide;
6-(difluoromethyl)-N-[5-fluoro-6-(2-fluoroethoxy)-2-methoxypyridin-3-yl]-1H-pyrrolo[2,3-b]pyridine-3-sulfonamide;
6-chloro-N-(6-cyclopropyl-2,5-difluoropyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine-3-sulfonamide;
6-chloro-N-[6-(2,2-difluoroethoxy)-5-fluoro-2-methoxypyridin-3-yl]-1H-indole-3-sulfonamide;
6-chloro-N-(6-cyclopropyl-2,5-difluoropyridin-3-yl)-1H-indole-3-sulfonamide;
N-[6-(2,2-difluoroethoxy)-5-fluoro-2-methoxypyridin-3-yl]-6-(difluoromethyl)-1H-pyrrolo[2,3-b]pyridine-3-sulfonamide;
6-chloro-N-[6-(2,2-difluoroethoxy)-5-fluoro-2-methoxypyridin-3-yl]-1H-pyrrolo[2,3-b]pyridine-3-sulfonamide;
N-[6-(2,2-difluoroethoxy)-2-methoxypyridin-3-yl]-6-(difluoromethyl)-1H-pyrrolo[2,3-b]pyridine-3-sulfonamide;
6-chloro-N-[6-(2,2-difluoroethoxy)-2-methoxypyridin-3-yl]-1H-pyrrolo[2,3-b]pyridine-3-sulfonamide;
N-[6-(2,2-difluoroethoxy)-2,5-difluoropyridin-3-yl]-6-(difluoromethyl)-1H-indole-3-sulfonamide;
6-chloro-N-[6-(difluoromethoxy)-4-methoxypyridin-3-yl]-1H-indole-3-sulfonamide;
6-chloro-N-[6-(2,2-difluoroethoxy)-2-methoxypyridin-3-yl]-1H-indole-3-sulfonamide;
6-chloro-N-[2-(2,2-difluoroethoxy)-6-methoxypyridin-3-yl]-1H-indole-3-sulfonamide;
N-[6-(difluoromethoxy)-5-fluoro-2-methoxypyridin-3-yl]-6-(difluoromethyl)-1H-pyrrolo[2,3-b]pyridine-3-sulfonamide;
6-chloro-N-[6-(difluoromethoxy)-2-methoxy-3-pyridyl]-1H-pyrrolo[2,3-b]pyridine-3-sulfonamide;
N-(6-chloro-5-fluoro-2-methoxypyridin-3-yl)-6-(difluoromethyl)-1H-pyrrolo[2,3-b]pyridine-3-sulfonamide;
6-chloro-N-[6-(2-fluoroethoxy)-2-methoxypyridin-3-yl]-1H-indole-3-sulfonamide;
6-chloro-N-[5-fluoro-6-(2-fluoroethoxy)-2-methoxypyridin-3-yl]-1H-pyrrolo[2,3-b]pyridine-3-sulfonamide;
6-chloro-N-[5-fluoro-6-(2-fluoroethoxy)-2-methoxypyridin-3-yl]-1H-indole-3-sulfonamide;
N-[6-(difluoromethoxy)-5-fluoro-2-methoxypyridin-3-yl]-6-(difluoromethyl)-1H-indole-3-sulfonamide;
6-chloro-N-[6-(difluoromethoxy)-5-fluoro-2-methoxypyridin-3-yl]-1H-pyrrolo[2,3-b]pyridine-3-sulfonamide;
6-chloro-N-(5-chloro-3-methoxypyrazin-2-yl)-1H-indole-3-sulfonamide;
6-chloro-N-[6-(difluoromethoxy)-5-fluoro-2-methoxypyridin-3-yl]-1H-indole-3-sulfonamide;
N-(5-bromo-3-methoxypyrazin-2-yl)-6-chloro-1H-indole-3-sulfonamide;
6-chloro-N-(2,5-difluoro-6-methylpyridin-3-yl)-1H-indole-3-sulfonamide;
6-chloro-N-(5-fluoro-2,6-dimethoxypyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine-3-sulfonamide;
6-chloro-N-(6-chloro-5-fluoro-2-methoxypyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine-3-sulfonamide;
6-chloro-N-(5-fluoro-2,6-dimethoxypyridin-3-yl)-1H-indole-3-sulfonamide;
6-chloro-N-(2,5-difluoro-6-methoxypyridin-3-yl)-1H-indole-3-sulfonamide;
6-chloro-N-(6-chloro-5-fluoro-2-methoxypyridin-3-yl)-1H-indole-3-sulfonamide;
6-chloro-N-(6-chloro-2,5-difluoropyridin-3-yl)-1H-indole-3-sulfonamide;
6-chloro-N-(6-iodopyridin-3-yl)-1H-indole-3-sulfonamide;
6-chloro-N-(6-chloro-4-fluoropyridin-3-yl)-1H-indole-3-sulfonamide;
and pharmaceutically acceptable salts, solvates, isotopes and co-crystals thereof.