Patent ID: 11963954
Assignee: ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 11:
12. A compound having a structure represented by a formula:, or a pharmaceutically acceptable salt thereof, wherein
R1a, R1b, and R1c are each independently hydrogen, halogen, —SF5, —NO2, —CH3, —CH2F, —CHF2, —CF3, —OCF3, —NHCH3, —N(CH3)2, —(CH2)-phenyl, —(CH2)-pyridinyl, —(CH2)-pyrimidinyl, —O-phenyl, —O-pyridinyl, or —O-pyrimidinyl, provided that at least one of R1a, R1b, and R1c is not hydrogen; or wherein R1a and R1b are optionally covalently bonded and, together with the intermediate atoms, comprise an optionally substituted 3- to 7-membered fused aryl, heteroaryl, cycloalkyl, cycloalkenyl, heterocycloalkyl, or heterocycloalkenyl; and wherein R1c is hydrogen, halogen, —OH, —SCF3, —SF5, —NO2, —CH3, —CH2F, —CHF2, —CF3, —OCF3, —NHCH3, or —N(CH3)2;
R2 is —(C1-C6 alkyl)-CF3, —(C1-C6 alkyl)-C≡CH, —(C1-C3 alkyl)-cyclopropyl, —(C1-C3 alkyl)-cyclobutyl, —(C1-C3 alkyl)-cyclopentyl, —(C1-C3 alkyl)-cyclohexyl, or —SO2—(C1-C6 alkyl); and wherein R2 is substituted with 0, 1, 2, or 3 groups independently selected from halogen, —OH, —SCF3, —SF5, —NO2, —CH3, —CH2F, —CHF2, —CF3, —OCF3, —NHCH3, and —N(CH3)2;
one of R10a, R10b, R10c, R10d, and R10e is —C(O)CH═CH2, —(CH2)C(O)CH═CH2, —NHC(O)CH═CH2, or —(CH2)NHC(O)CH═CH2, at least two of R10a, R10b, R10c, R10d, and R10e are independently hydrogen, and the remaining R10a, R10b, R10c, R10d, and R10e are each independently hydrogen, halogen, —SF5, —NO2, —CH3, —CH2F, —CHF2, —CF3, —OCF3, —NHCH3, or —N(CH3)2.