Patent ID: 11890294
Assignee: HYPHENS PHARMA PTE. LTD.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 24:
25. A method of treating or reducing likelihood of a condition caused by a defective skin barrier or for promoting skin barrier repair, wherein the condition is selected from the group consisting of eczema, atopic eczema, dermatitis, atopic dermatitis, non-atopic eczema, non-atopic dermatitis, seborrheic eczema, irritant contact dermatitis, allergic contact dermatitis, asteatotic eczema, pruritis, acne, dry skin and sensitive skin, the method comprising topical application of a composition to an external body surface of a subject who is affected by, or is at risk of being affected by, said condition or who is in need of skin barrier repair;
wherein the composition comprises:
an aqueous-glycol phase comprising:
a polyhydroxy acid and a zinc salt of its conjugate base at 4.0-6.0% w/w, wherein the polyhydroxy acid is selected from the group consisting of lactobionic acid, gluconolactone (gluconic acid), a combination of lactobionic acid and gluconolactone (gluconic acid), and derivatives thereof;
a partition coefficient enhancer selected from the group consisting of propylene glycol, butylene glycol, pentylene glycol, hexylene glycol, 1,5 pentane diol, propylene carbonate, dipropylene glycol, diethylene glycol monoethyl ether, N-methyl pyrrolidone and a combination thereof at 18.0-22.0% w/w; and
water; and

an oil phase comprising:
a diffusion coefficient enhancer which is a C12 to C14 straight chain fatty acid or a C14 straight chain primary alcohol at 1.0-2.0% w/w;
a second agent as emollient; and
a third agent as surfactant;

wherein % w/w is based on the composition, and wherein the composition has a pH in the range consisting of 3.0 to 3.5.