Patent ID: 11919863
Assignee: BRISTOL-MYERS SQUIBB COMPANY
Field: Organic fine chemistry (Chemistry)
Classification: CPC C | IPC C

Claim 9:
10. The method of claim 6, wherein the compound of formula IV is prepared by contacting a compound of formula VI-A or VI-B:, , wherein n is 1 or 2; with a compound of formula VII, , wherein Y is halo;
in the presence of a suitable C1-6alkylsilylamine base, in a suitable organic solvent, for a time and at a temperature sufficient for Y displacement to produce a compound of formula VIII-A or formula VIII-B;, , and
contacting the compound of formula VIII-A or formula VIII-B with a suitable hydroxide base, in a suitable aqueous solvent, for a time and at a temperature sufficient for hydrolysis to produce a compound of formula IX-A or formula IX-B;, , and
contacting the compound of formula IX-A or formula IX-B, with a suitable mineral acid, in a suitable aqueous solvent, for a time and at a temperature sufficient for hydrolysis and decarboxylation to produce the compound of formula IV.