Patent ID: 11884644
Assignee: SHANDONG JINCHENG PHARMACEUTICAL CHEMICAL CO., LTD.
Field: Organic fine chemistry (Chemistry)
Classification: CPC C  Y | IPC C

Claim 19:
20. A method for synthesizing (S)-nicotine, comprising: preparing (S)-4-amino-4-(3-pyridyl)-1-butanol by the method according to claim 1; performing an N-methylation reaction on (S)-4-amino-4-(3-pyridyl)-1-butanol with a methylating agent to obtain (S)-4-(methylamino)-4-(3-pyridyl)-1-butanol, and making the obtained intermediate (S)-4-(methylamino)-4-(3-pyridyl)-1-butanol react with an acylating agent or a halogenating agent to convert an alcoholic hydroxyl group thereof into a sulfonate group or a halogen; and directly performing a ring closure reaction on a product without separation to obtain a final product (S)-nicotine with the reaction controlled in an alkaline condition.