Patent ID: 11891482
Assignee: TYNDALL FORMULATION SERVICES, LLC
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 11:
12. A method of preparing a composition comprising a multiblock copolymer of Formula I:, wherein:
R1a is H or an optionally substituted aliphatic group;
R1b is H or an optionally substituted aliphatic group;
R2 is H, an optionally substituted aliphatic group or an optionally substituted CO—(C1-C6)aliphatic group;
each Ry is independently the side chain of γ-benzyl-D-glutamate, D-leucine, D-tyrosine, D-phenylalanine, D-alanine, D-valine, D-isoleucine, D-norleucine, O-acetyl-D-tyrosine, O-benzyl-D-tyrosine, or ε-benzyl-D-lysine;
each Rz is independently the side chain of γ-benzyl-L-glutamate, L-leucine, L-tyrosine, L-phenylalanine, L-alanine, L-valine, L-isoleucine, L-norleucine, O-acetyl-L-tyrosine, O-benzyl-L-tyrosine, or ε-benzyl-L-lysine;
x is 125-350;
y is 5-35; and
z is 5-35,, the method comprising:
a. dissolving a hydrophobic molecule in an organic solvent, to produce a hydrophobic molecule solution;
b. dissolving a copolymer of Formula I and, optionally, a cryoprotectant, in an aqueous solution, to produce a copolymer solution; and
c. mixing the hydrophobic molecule solution and the copolymer solution to produce a mixed solution, and optionally lyophilizing the mixed solution.