Patent ID: 11959096
Assignee: THE MEDICAL COLLEGE OF WISCONSIN, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A method of obtaining a population of stem cell-derived cell types substantially free of undifferentiated pluripotent stem cells, the method comprising
(a) inducing undifferentiated pluripotent stem cells to differentiate or partially differentiate into one or more stem cell-derived cell types;
(b) contacting an effective amount of a compound to the induced cell population, wherein the compound is a nicotinamide phosphoribosyltransferase (NAMPT) inhibitor, whereby the contacting selectively reduces or eliminates undifferentiated pluripotent stem cells from the induced cell population; and
(c) isolating the contacted cells to obtain a population of one or more stem cell-derived cell types, wherein the population is substantially free of undifferentiated pluripotent stem cells.