Patent ID: 11939632
Assignee: ROCHE SEQUENCING SOLUTIONS, INC.
Field: Biotechnology (Chemistry)
Classification: CPC C | IPC C

Claim 5:
6. A system for analyzing nucleic acid molecules, the system comprising:
a transistor comprising a gate electrode in contact with a semiconductor material disposed between a source electrode and a drain electrode;
a template parent strand affixed to a particle, wherein:
the particle has a diameter or characteristic dimension in a range from 10 nm to 50 nm, and
the particle contacts a side of the semiconductor material opposite the gate electrode;

a nucleic acid polymerase configured to elongate a nascent strand hybridized to the template parent strand, wherein the nucleic acid polymerase is not the particle;
a nucleotide attached to a label compound comprising a moiety;
a power supply in electrical communication with the transistor; and
a meter device configured to measure an electrical characteristic of the transistor from the moiety after the nucleic acid polymerase incorporates the nucleotide and after the nucleic acid polymerase cleaves the nucleotide from the label compound.