Patent ID: 11951148
Assignee: FLEURIR ABX, LLC
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  Y | IPC A

Claim 0:
1. A composition for utilization in a subject in need thereof having or suspected of having an aerobic bacteria susceptible to the composition, the composition comprising:
an effective amount of an inhibitor of lipid A deacetylase, the inhibitor being one that inhibits lipid A deacetylase in the aerobic bacteria, and the effective amount of the inhibitor causing permeabilization of an outer membrane of the aerobic bacteria thereby compromising integrity of the aerobic bacteria,
wherein the composition comprising the effective amount of the inhibitor is a pharmaceutically acceptable form of the composition and in a form suitable for administration of the composition to the subject in need thereof, the composition optionally including one or more pharmaceutically acceptable excipients for administration of the composition,
wherein the composition, when causing permeabilization of the outer membrane of the aerobic bacteria, inhibits or prevents formation of the outer membrane of the aerobic bacteria,
wherein the aerobic bacteria is one or more aerobic bacteria causing or suspected of causing an infection in the subject in need thereof,
wherein the aerobic bacteria is Gram-negative and is targeted by the composition,
wherein the composition is in the form of at least one of Formula I, Formula II, and Formula III, or a stereoisomer thereof, or pharmaceutically acceptable salt thereof, in which Formula I is:, and Formula II is:, and Formula III is:, wherein R1 is any one of:, wherein R2 is any one of:, and wherein R3 is any one or more of:,