Patent ID: 11963996
Assignee: ORTHOTROPHIX, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 6:
7. A method of impacting age related shape change of bone underlying articular cartilage in a patient, comprising:
(a) obtaining and measuring a first computerized tomography or MRI image of a patella bone shape at a joint of a patient
(b) locally injecting into the joint of the patient a therapeutically effective amount of a formulation comprising a pharmaceutically acceptable, injectable carrier, and a pharmaceutically active peptide characterized by impacting age related shape change of bone at a joint underlying articular cartilage in the patient;
(c) obtaining and measuring a second computerized tomography or MRI image of the patella bone shape underlying articular cartilage after the injecting; and
(d) comparing the measurement of the patella bone shape in the first image obtained in step (a) with the measurement of the patella bone shape in the second image obtained in step (c); and
(e) determining impact of whether or not the patella bone shape significantly change changed from the injecting based on the comparing step (d); and
(f) repeating step (b) if the patella bone shape significantly changed based on the determining step (e)
wherein:
the peptide is a peptide selected from the group consisting of the peptide of SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, and SEQ ID NO: 6; and
the measuring and comparing are performed using active appearance modeling (AAM).