Patent ID: 11969476
Assignee: VISTERRA, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C  Y | IPC A  C

Claim 0:
1. An antibody molecule-drug conjugate (ADC) comprising an antibody molecule and a covalently coupled peptide,
wherein the antibody molecule is capable of binding to lipopolysaccharide (LPS) on Pseudomonas aeruginosa and comprises a heavy chain variable region (VH), wherein the VH comprises three heavy chain complementarity determining regions (HCDR1, HCDR2, and HCDR3), and wherein the VH comprises:
(a) an HCDR1 comprising the amino acid sequence of SEQ ID NO: 105; an HCDR2 comprising the amino acid sequence of SEQ ID NO: 106; and an HCDR3 comprising the amino acid sequence of SEQ ID NO: 107, or
(b) an HCDR1 comprising the amino acid sequence of SEQ ID NO: 108; an HCDR2 comprising the amino acid sequence of SEQ ID NO: 146; and an HCDR3 comprising the amino acid sequence of SEQ ID NO: 107; and
wherein the antibody molecule comprises a light chain variable region (VL), wherein the VL comprises three light chain complementarity determining regions (LCDR1, LCDR2, and LCDR3), and wherein the VL comprises an LCDR1 comprising the amino acid sequence of SEQ ID NO: 138; an LCDR2 comprising the amino acid sequence of SEQ ID NO: 142; and an LCDR3 comprising the amino acid sequence of SEQ ID NO: 112; and
wherein the peptide comprises the amino acid sequence of SEQ ID NO: 257.