Patent ID: 11945873
Assignee: GENSUN BIOPHARMA INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A bispecific antibody comprising two heavy chains and two light chains, wherein each heavy chain comprises, from N-terminus to C-terminus, a VH domain, a CHI domain, a CH2 domain, a CH3 domain, a peptide linker and a TGF-ß1 RII extracellular domain (ECD), wherein each light chain comprises, from N-terminus to C-terminus, a VL domain and a CL domain, wherein the VH domain comprises the amino acid sequence of SEQ ID NO:90 or 96, wherein the VL domain comprises the amino acid sequence of SEQ ID NO:91, wherein the bispecific antibody binds specifically to (1) human VEGF-A through the VH and VL domains and (2) human TGFß1 through the TGF-ß1 RII extracellular domain (ECD), wherein the TGF-ß1 R11 ECD comprises the amino acid sequence of SEQ ID NO:89.