Patent ID: 11926616
Assignee: INCYTE CORPORATION
Field: Organic fine chemistry (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 11:
12. The method of claim 1, wherein:
X1 is N or CH;
R2 is C(O)NRc1Rd1;
each Rc1 and Rd1 is independently selected from H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, 4-10 membered heterocycloalkyl, C6-10 aryl-C1-6 alkyl-, C3-10 cycloalkyl-C1-6 alkyl-, (5-10 membered heteroaryl)-C1-6 alkyl-, and (4-10 membered heterocycloalkyl)-C1-6 alkyl-, wherein the C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, 4-10 membered heterocycloalkyl, C6-10 aryl-C1-6 alkyl-, C3-10 cycloalkyl-C1-6 alkyl-, (5-10 membered heteroaryl)-C1-6 alkyl-, and (4-10 membered heterocycloalkyl)-C1-6 alkyl- of Rc1 and Rd1 are each optionally substituted with 1, 2, 3, or 4 independently selected RA substituents;
or, any Rc1 and Rd1, attached to the same N atom, together with the N atom to which they are attached, form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group, wherein the 4-, 5-, 6-, or 7-membered heterocycloalkyl group is optionally substituted with 1 or 2 independently selected RA substituents;
each RA is independently selected from D, halo, oxo, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, CN, NO2 and ORa4, wherein the C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl of RA is optionally substituted with 1 or 2 independently selected RD substituents;
each Ra4 is independently selected from H and C1-6 alkyl, wherein the C1-6 alkyl is optionally substituted CN, NO2 or OH;
each RD is OH;
each R3, R4, and R5 is independently selected from H, D, halo, CN, OH, Ci-3 alkyl, and Ci-3 haloalkyl, wherein the Ci-3 alkyl is optionally substituted by 1, 2, 3, 4, 5, or 6 D; and
each R6, R7, and R8 is independently selected from H, D, C1-6 alkyl and C1-6 haloalkyl.