Patent ID: 11950903
Assignee: SENSEONICS, INCORPORATED
Field: Medical technology (Instruments)
Classification: CPC A  G | IPC A  G

Claim 14:
15. An analyte monitoring method comprising:
using an analyte monitoring sensor of an analyte monitoring system to measure glucose levels of a patient, wherein using the analyte monitoring sensor of the analyte monitoring system to measure the glucose levels of the patient comprises using a fluorometer of the analyte monitoring sensor to measure the glucose levels of the patient, using the fluorometer of the analyte monitoring sensor to measure the glucose levels of the patient comprises using the fluorometer to measure parameters of fluorescence after and/or during excitation by a spectrum of light, and the measured parameters include an intensity and/or a wavelength distribution of emission spectrum of the fluorescence;
using the analyte monitoring sensor to communicate over a wireless communication link;
using an analyte monitoring device of the analyte monitoring system to obtain a first glucose measurement indicative of a first glucose level of the patient;
using the analyte monitoring device to obtain a second glucose measurement indicative of a second glucose level of the patient;
using the analyte monitoring device to add the first and the second glucose measurements to a glucose measurement data set;
using a processor of the analyte monitoring device to calculate an estimated HbA1c level using the glucose measurement data set and the following formula:, [
     
      H
      ⁢
      b
      ⁢
      
       A
       
        1
        ⁢
        c
       
      
     
     ]
    
    
     [
     
      H
      ⁢
      b
     
     ]
    
   
   ⁢
   
    (
    
     mmol
     mol
    
    )
   
  
  =
  
   
    [
    
     G
     ⁢
     L
     ⁢
     U
    
    ]
   
   ⁢
   
    (
    t
    )
   
   *
   
    (
    
     
      
       
        k
        1
       
       ⁢
       
        k
        2
       
      
      
       
        k
        
         -
         1
        
       
       +
       
        k
        2
       
      
     
     ⁢
     
      (
      
       
        e
        
         
          -
          
           k
           3
          
         
         ⁢
         t
        
       
       -
       
        e
        
         
          -
          
           (
           
            
             k
             3
            
            +
            
             k
             
              -
              1
             
            
            +
            
             k
             2
            
           
           )
          
         
         ⁢
         t
        
       
      
      )
     
    
    )
   
  
 

where k1 is an association constant that represents a binding constant when a glucose attaches to a hemoglobin to form a pre-A1c, k−1 is an association constant that represents a dissociation constant when the glucose detaches from the hemoglobin, k2 is an association constant that represents a conversion of the pre-A1c to an HbA1c and k3 is an association constant that represents a life span of the pre-A1c and the HbA1c;
using the processor of the analyte monitoring device to calculate a standard deviation of the estimated HbA1c level using the glucose measurement data set;
using the processor of the analyte monitoring device to combine the estimated HbA1c level with the standard deviation of the estimated HbA1c level to acquire a range of the estimated HbA1c level; and
using a display of the analyte monitoring device to display the range of the estimated HbA1c level.