Patent ID: 11905323
Assignee: BRACCO SUISSE
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A  G | IPC A  C

Claim 0:
1. A conjugate compound comprising:
a dimeric protein comprising two recombinant chimeric P-Selectin Glycoprotein Ligand-1 (PSGL-1) proteins, wherein the monomeric recombinant chimeric PSGL-1 protein comprises at least: a selectin Binding domain able to specifically bind a selectin protein and comprising at least aa 5-16 of SEQ ID NO:11 (mature PSGL-1 sequence), a leucine zipper domain able to form a right-handed a helix thus promoting dimerization through protein-protein interaction and comprising an amino acid sequence at least 90% homologous or identical to aa 187-208 of SEQ ID NO:12 (Neural Retina-specific Leucine Zipper) and a disulfide bonds promoting region comprising at least one cysteine available to form a disulfide bond with another cysteine in a monomeric chimeric protein counterpart, so that the two chimeric protein monomers are covalently linked to each other by at least a disulfide bond; and
a diagnostic or therapeutic moiety.