Patent ID: 11939317
Assignee: RIGEL PHARMACEUTICALS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC C

Claim 14:
15. The compound of claim 12, wherein R4 is Br,, , where y is 0, 1 or 2, and each Rp independently is Ra, Rb, Ra substituted with Rb, or Ra substituted with Rc;
Ra is independently for each occurrence H, D, C1-6 alkyl, C3-6 cycloalkyl, C5-10aromatic, or C3-6heterocycloaliphatic;
Rb is independently for each occurrence —OH, —CF3, —CN, —ORc, —SO2Rc, —NRdRd, —N(H)SO2Rc, —C(O)OH, —N(H)C(O)Rc, —C(O)ORc, —C(O)NRdRd, ═O, or halogen;
Rc is independently for each occurrence C1-6 alkyl, C3-6 cycloalkyl, C3-6 heteroalicyclyl, aralkyl, C1-6alkyl substituted with 1, 2 or 3 Re, C5-10aromatic, C5-10aromatic substituted with 1, 2 or 3 Re;
Rd is independently for each occurrence H, C1-6alkyl optionally substituted with 1, 2 or 3 Re, C3-6cycloalkyl optionally substituted with 1, 2 or 3 Re, C3-6 heteroalicyclyl optionally substituted with 1, 2 or 3 Re, C5-10aromatic optionally substituted with 1, 2 or 3 Ra or Rb, or two Rd groups together with the nitrogen bound thereto form a C3-6 heteroalicyclyl moiety optionally substituted with C1-6 alkyl and optionally interrupted with one or two —O— or —N(Rg) wherein Rg is H, C1-10aliphatic, heteroaliphatic, or cycloaliphatic; and
Re is independently for each occurrence halogen, C1-6 alkyl, C3-6 cycloalkyl, or —ORa.