Patent ID: 11946044
Assignee: GUARDANT HEALTH, INC.
Field: Biotechnology (Chemistry)
Classification: CPC C | IPC C

Claim 0:
1. A method of isolating DNA from a sample, the method comprising:
partitioning the DNA of the sample into a plurality of partitions, the plurality of partitions comprising at least a hypermethylated partition and a hypomethylated partition;
preparing a first pool comprising at least a first portion of the DNA from the hypomethylated partition;
preparing a second pool comprising at least a first portion of the DNA from the hypermethylated partition;
capturing at least a first set of target regions from the first pool; and
capturing at least a second set of target regions from the second pool,
wherein the first set of target regions and the second set of target regions are not identical, and further wherein:
(a) the first pool comprises only a portion of the DNA of the hypermethylated partition;
and/or
(b) the plurality of partitions further comprises an intermediately methylated partition and the second pool comprises only a portion of the DNA of the intermediately methylated partition.