Patent ID: 11964007
Assignee: JANSSEN VACCINES & PREVENTION B.V.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 0:
1. A method of inducing an immune response in a human subject in need thereof, the method comprising:
a. administering to the human subject a first composition comprising an immunologically effective amount of an in vitro transcribed (IVT) self-replicating RNA (repRNA) comprising a first polynucleotide encoding a first antigenic protein or an immunogenic polypeptide thereof, together with a pharmaceutically acceptable carrier, wherein the IVT repRNA is formulated into a non-virion particle, and
b. administering to the subject a second composition comprising an immunologically effective amount of a recombinant human adenovirus serotype 26 (Ad26) vector or a recombinant human adenovirus serotype 35 (Ad35) vector comprising a second polynucleotide encoding a second antigenic protein or an immunogenic polypeptide thereof, together with a pharmaceutically acceptable carrier,, to thereby obtain an induced immune response in the human subject, wherein the first or second antigenic protein is derived from an Influenza virus, and wherein the first and second antigenic proteins share at least one antigenic determinant, and one of the compositions is a priming composition and the other composition is a boosting composition.