Patent ID: 11971374
Assignee: UNIVERSITY OF MARYLAND, BALTIMORE
Field: Measurement (Instruments)
Classification: CPC G | IPC G

Claim 0:
1. A method of detecting a filling error of an alum-containing product in real-time and in-line during a fill-finish unit operation, said method comprising:
introducing the alum-containing product into a filling conduit, wherein the filling conduit directs the alum-containing product into a vial, and wherein the filling conduit is arranged to pass through a magnet of a nuclear magnetic resonance (NMR) spectrometer prior to reaching the vial;
measuring a transverse relaxation time of water T2,m in the alum-containing product passing through the filling conduit; and
comparing the measured T2,m to a reference transverse relaxation time of water T2,r, wherein T2,r, is a range which is considered an acceptable flow rate or concentration of aluminum particles in the alum-containing product,
wherein when the measured T2,m is within the range of the reference T2,r, there is no filling error.