Patent ID: 11952376
Assignee: PLIANT THERAPEUTICS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 135:
136. The compound of claim 125, wherein the compound is of formula (II-A-2):, , or a pharmaceutically acceptable salt, stereoisomer, or tautomer thereof,
wherein:
R2 is pyridin-2(1H)-onyl, 4,5,6,7-tetrahydro-1H-indazol-4-yl, 4,5,6,7-tetrahydro-1H-indazol-5-yl, 4,5,6,7-tetrahydro-1H-indazol-6-yl, 4,5,6,7-tetrahydro-1H-indazol-7-yl, 5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridin-5-yl, 5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridin-6-yl, 5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridin-7-yl, 5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridin-8-yl, pyrazolyl, pyridinyl, pyrimidinyl, 1Hindazol-4-yl, 1H-indazol-5-yl, 1H-indazol-6-yl, 1H-indazol-7-yl, quinolin-5-yl, quinolin-6-yl, quinolin-7-yl, quinolin-8-yl, 1H-pyrrolo[3,2-b]pyridin-5-yl, 1H-pyrrolo[3,2-b]pyridin-6-yl, 1H-pyrrolo[3,2-b]pyridin-7-yl, 1H-pyrrolo[2,3-b]pyridin-4-yl, 1H-pyrrolo[2,3-b]pyridin-5-yl, or 1H-pyrrolo[2,3-b]pyridin-6-yl:
wherein the pyridin-2(1H)-onyl, 4,5,6,7-tetrahydro-1H-indazol-4-yl, 4,5,6,7-tetrahydro-1H-indazol-5-yl, 4,5,6,7-tetrahydro-1H-indazol-6-yl, 4,5,6,7-tetrahydro-1H-indazol-7-yl, 5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridin-5-yl, 5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridin-6-yl, 5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridin-7-yl, 5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridin-8-yl is optionally substituted by 1, 2, 3, or 4 independently selected R2c substituents; and
wherein the pyrazolyl, pyridinyl, pyrimidinyl, 1H-indazol-4-yl, 1H-indazol-5-yl, 1H-indazol-6-yl, 1H-indazol-7-yl, quinolin-5-yl, quinolin-6-yl, quinolin-7-yl, quinolin-8-yl, 1H-pyrrolo[3,2-b]pyridin-5-yl, 1H-pyrrolo[3,2-b]pyridin-6-yl, 1H-pyrrolo[3,2-b]pyridin-7-yl, 1H-pyrrolo[2,3-b]pyridin-4-yl, 1H-pyrrolo[2,3-b]pyridin-5-yl, or 1H-pyrrolo[2,3-b]pyridin-6-yl is optionally substituted by 1, 2, 3, or 4 independently selected R2e substituents.