Patent ID: 11912703
Assignee: BRISTOL-MYERS SQUIBB COMPANY
Field: Organic fine chemistry (Chemistry)
Classification: CPC C  A | IPC C

Claim 1:
2. The compound according to claim 1, N-oxide, or a salt thereof, wherein:
A is:
(i) —NR7R8 wherein R7 and R8 together with the nitrogen atom to which they are attached form a heterocyclic ring selected from piperazinyl, piperidinyl, or diazaspiro[3.3]heptanyl, wherein said heterocyclic ring is substituted with zero to 1 R7b and zero to 1 R7c; or
(ii) —CHR12R13, wherein R12 and R13 together with the carbon atom to which they are attached form a cyclic group selected from cyclopentyl, cyclohexyl, morpholinyl, or piperidinyl, each substituted with zero to 1 R12a;
R1 is —CH3 or —CH(CH3)2;
each R2 is independently —CH3 or —OCH3;
R5 is F, Cl, or —CH3;
R7b is:
(i) —CH3, —CH2CH3, —CH2CH2CH3, —CH(CH3)2, —CH2CH(CH3)2, —CH2CF3, —CH2CN, —CH2C(CH3)2OH, —CH2CH2OCH3, —CH2CH2S(O)2CH3, —(CH2)1-2NRxRx, —CH2C(O)NRxRx, —NRxRy, —NRx(C1-4 hydroxyalkyl), —NH(CH2CRxRxOCH3), —NRy(C1-2 cyanoalkyl), —NRx(C1-2 fluoroalkyl), —NRx(C2-5 hydroxyfluoroalkyl), —NRx(CH2)1-2C(O)NRxRx, —NRx(CH2)1-3NRxRx, —NRxCH2CH2N(CH3)2, —NRxC(O)(CH2)1-2NRxRx, —C(O)CH3, —C(O)CH2NRxRx, —S(O)2CH3, —(CH2)1-2R7d, —CH2C(O)R7d, —C(O)CH2R7d, —NHR7d, —NH(CH2)1-2R7d, or —OR7d; or
(ii) azetidinyl, cyclobutyl, dioxothiomorpholinyl, morpholinyl, oxaazaspiro[3.3]heptanyl, oxetanyl, piperazinonyl, piperazinyl, piperidinyl, tetrahydrofuranyl, or tetrahydropyranyl, each substituted with zero to 1 R8a;

R7c is —CH3;
R8a is —CH3, —CH(CH3)2, or —S(O)2CH3;
R12a is —CH(CH3)2, —CH2CF3, —CH2C(CH3)2OH, —CH2CH2OCH3, —CH2C(O)NH(CH3), —CH2C(O)N(CH3)2, —CH2C(O)NH2, —CH2CH2S(O)2CH3, —CH2CH2NH(CH3), —NRxRy, —NRx(C2-4 fluoroalkyl), —NH(CH2C(CH3)2OH), —NH(CH2CHFC(CH3)2OH), —NH(CH2CH2OCH3), —NH(CH2C(CH3)2OCH3), —NRx(CH2C(O)NRxRx), —C(O)CH2NH(CH3), —C(O)CH2N(CH3)2, R12b, —CH2R12b, —NRxR12b, —N(CH2CN)R12b, or —NRxCH2R12b;
R12b is azetidinyl, bicyclo[1.1.1]pentanyl, oxaazaspiro[3.3]heptanyl, oxetanyl, piperidinyl, tetrahydrofuranyl, or tetrahydropyranyl, each substituted with zero to 4 substituents independently selected from —CH3, —CH(CH3)2, —CH2OH, or —OCH3; and
n is zero or 1.