Patent ID: 11859250
Assignee: CHILDREN'S HOSPITAL MEDICAL CENTER
Field: Biotechnology (Chemistry)
Classification: CPC C | IPC C

Claim 10:
11. A method for treating eosinophilic esophagitis (EoE) in a subject in need thereof, the method comprising
subjecting a biological sample from the subject to a method for gene expression analysis,
determining the expression of a panel of genes in the biological sample, the panel comprising ACTG2, CCR3, FFAR3, IL4, RGS9BP, and TSLP,
determining the subject's EoE endotype is intermediate based on the expression of the panel of genes, wherein an increase in expression of one or more of ACTG2, CCR3, FFAR3, IL4, RGS9BP, and TSLP by at least 2-fold compared to a reference indicates the subject's EoE endotype is intermediate,
and
treating the patient with an EoE therapy comprising one or more of anti-cytokine therapy and anti-TSLP therapy, but not glucocorticoid therapy.