Patent ID: 11911406
Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C  Y | IPC A  C

Claim 0:
1. A polymer-drug conjugate comprising:
a polymer comprising a plurality of masked cationic functional groups wherein the masked cationic functional groups are converted in aqueous solution to free cationic functional groups faster at a pH below 7 than a pH above 7; wherein
the cationic functional groups are masked as either an uncharged functional group or by an ion pair with a neighboring anionic functional group attached to the polymer; and

an antibiotic drug linked to the cationic polymer by a pH-sensitive linker that releases the drug faster in aqueous solution at a pH value selected from a range of 4.5 to 7 compared to a pH value above 7; and wherein
the polymer comprises one or more disulfide bonds in a backbone of the polymer;
the plurality of masked cationic functional groups comprise amide, amine, amidine, guanidine, ammonium, amidinium, and/or guanidinium functional groups; and
the pH-sensitive linker is selected from the group consisting of hydrazone, 2,3-dimethyl maleic acid ester and/or amide, imine, ketal, acetal, and phenyl boronic acid and ester.