Patent ID: 11918832
Assignee: INSIGHTEC LTD.
Field: Medical technology (Instruments)
Classification: CPC A | IPC A

Claim 21:
22. A system for temporarily disrupting a patient's blood-brain barrier (BBB), the system comprising:
an ultrasound transducer; and
a controller configured to:
(a) store a first threshold value of a cumulative acoustic response dose associated with at least one of a target BBB region or its surrounding regions, the first threshold value corresponding to a maximum clinically tolerable cumulative amount of microbubble cavitation;
(b) store a second threshold value of an acoustic response value associated with the at least one of the target BBB region or its surrounding regions, the second threshold value corresponding to a maximum clinically tolerable magnitude of microbubble cavitation;
(c) during a sonication cycle, cause the transducer to transmit a plurality of ultrasound pulses;
(d) for each ultrasound pulse, acquire the acoustic response value associated with the at least one of the target BBB region or its surrounding regions, and compare the acquired acoustic response value with the second threshold value;
(e) during the sonication cycle, acquire the cumulative acoustic response dose associated with the at least one of the target BBB region or its surrounding regions, and compare the acquired cumulative acoustic response dose with the first threshold value; and
(f) suspend ultrasound sonication when the cumulative acoustic response dose acquired in step (e) exceeds the first threshold value or when the acoustic response value acquired in step (d) exceeds the second threshold value.