Patent ID: 11872225
Assignee: AGIOS PHARMACEUTICALS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 12:
13. The method of claim 1, wherein the compound is of Formula (V-a):, , or a pharmaceutically acceptable salt thereof, wherein:
Ra and Rb are each independently hydrogen, halogen, —CN, —NO2, —N3, optionally substituted alkyl, —ORo3, —N(Rn1)2, —C(═O)N(Rn1)2, or —C(═O)Rc2, or Ra and Rb can be taken together with the carbon atom to form optionally substituted cycloalkyl or optionally substituted heterocyclyl;
each instance of Rn1 is independently hydrogen, optionally substituted —C1-C6 alkyl, or a nitrogen protecting group;
each instance of Ro3 is independently hydrogen, optionally substituted —C1-C6 alkyl, or an oxygen protecting group;
each instance of Rc2 is independently optionally substituted —C1-C6 alkyl;
each instance of Rn is independently hydrogen, a halogen, —CN, —NO2, —N3, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted aryl, an optionally substituted heterocyclyl, an optionally substituted heteroaryl, —ORo4, —SRs1, —N(Rn2)2, —C(═O)N(Rn2)2, —N(Rn2)C(═O)Rc3, —C(═O)Rc3, —C(═O)ORo4, —OC(═O)Rc3, —S(═O)Rs1, —S(═O)2Rs1, —S(═O)ORo4, —OS(═O)Rc3, —S(═O)2ORo4, —OS(═O)2Rc3, —S(═O)N(Rn2)2, —S(═O)2N(Rn2)2, —N(Rn2)S(═O)Rs1, —N(Rn2)S(═O)2Rs1, —N(Rn2)C(═O)ORo4, —OC(═O)N(Rn2)2, —N(Rn2)C(═O)N(Rn2)2, —N(Rn2)S(═O)N(Rn2)2, —N(Rn2)S(═O)2N(Rn2)2, —N(Rn2)S(═O)ORo4, —N(Rn2)S(═O)2ORo4, —OS(═O)N(Rn2)2, or —OS(═O)2N(Rn2)2; or two instances of Rn attached to the same or adjacent carbon atoms, taken together with the carbon atoms to which they are attached to form an optionally substituted cycloalkyl or a heterocycloalkyl; wherein:
each instance of Rn2 is independently hydrogen, an optionally substituted —C1-C6 alkyl, or a nitrogen protecting group;
each instance of Ro4 is independently hydrogen, an optionally substituted —C1-C6 alkyl, or an oxygen protecting group;
each instance of Rc3 is independently an optionally substituted —C1-C6 alkyl;
each instance of Rs1 is independently an optionally substituted —C1-C6 alkyl or a sulfur protecting group;
n is 0, 1, 2, or 3, as valency permits; and, m is 0, 1, or 2.