Patent ID: 11951161
Assignee: GLAXOSMITHKLINE BIOLOGICALS SA
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C  Y | IPC A

Claim 0:
1. A method for inducing an immune response in a human subject comprising administering to the subject:
(a) a first immunogenic composition comprising one or more antigens and a first adjuvant, and
(b) a second immunogenic composition comprising one or more antigens and a second adjuvant,, wherein:
(i) the time interval between administration of the first immunogenic composition and the second immunogenic composition is between 1 and 24 months,
(ii) the first and second immunogenic compositions have at least one antigen in common, the common antigen is a Plasmodium antigen, and the second immunogenic composition contains between 2-50 fold lower amount of said common antigen than the first composition, and
(iii) the first and second adjuvants comprise 3D-MPL and QS21 in a liposomal formulation in the same relative proportions, and the second immunogenic composition contains between 2-50 fold lower amount of said liposomal adjuvant than the first immunogenic composition.