Patent ID: 11866754
Assignee: MODERNATX, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A cap analog of formula (I):, or a stereoisomer, tautomer or salt thereof, wherein, is, ring B1 is, in which
R1 is C1 alkyl;
each of Ra and Rb is H; and
Rc is H;
ring B2 and ring B3 are each independently selected from, wherein
X1 is N or N+(R5);
R5 is C1-C6 alkyl, C2-C6 alkenyl, or C2-C6 alkynyl, each of which is optionally substituted with one or more substituents selected from the group consisting of C6-C10 aryl, C6-C10 aryloxyl, 5- to 10-membered heteroaryl, and 5- to 10-membered heteroaryloxyl, each being optionally substituted with one or more of halo and cyano;
each of Rd and Re independently is H, C1-C6 alkyl, or an amine protecting group, or Rd and Re, together with the nitrogen atom to which they attach, form a 4 to 12-membered heterocycloalkyl, —N═CH—Ru, or —N═N—Ru, wherein RB is phenyl and each of the 4 to 12-membered heterocycloalkyl and RB is optionally substituted with one or more substituents selected from OH, halo, oxo, C1-C6 alkyl, COOH, C(O)O—C1-C6 alkyl, cyano, C1-C6 alkoxyl, amino, mono-C1-C6 alkylamino, and di-C1-C6 alkylamino;
Rf is H, NH2, or C1-C6 alkyl; or Rf and one of Rd and Re, together with the two nitrogen atoms to which they attach and the carbon atom connecting the two nitrogen atoms form a 5- or 6-membered heterocycle which is optionally substituted with one or more of OH, halo, C1-C6 alkyl, C2-C6 alkenyl, and C2-C6 alkynyl;
Rg is H or methyl;
Rh is H or methyl;
X2 is O;
Y2 is (OP(O)R4)m in which m is 1;
R2 is locked nucleic acid (LNA);
R2′ is OR3;
R3 is H;
each of R4 and R4′ is OH;
each of R20, R21, R22, and R23 is —Q3-T3, in which Q3 is a bond, and T3 is H;
each of R27 and R28 is OR29; and
each R29 is H.