Patent ID: 11857702
Assignee: NATVI
Field: Medical technology (Instruments)
Classification: CPC A  C  B  F | IPC A  C

Claim 4:
5. A method for lubricating a hydrophobic support comprising the steps of:
a. covering the hydrophobic support with a first composition comprising
a solvent, and
a solute selected from stearylamine or stearic acid, to obtain a support covered with the first composition, the solvent being compatible with the solute and the hydrophobic surface;

b. rinsing the hydrophobic support covered with the first composition with an aqueous solution in order to obtain a hydrophobic support covered with the first rinsed composition;
c. bringing the hydrophobic support covered with the first rinsed composition into contact with free hyaluronic acid in order to obtain a surface having free hyaluronic acid;
d. crosslinking the free hyaluronic acid present on the surface obtained in the previous step by using a crosslinking agent in order to obtain a first layer of crosslinked hyaluronic acid; and
e. bringing the first layer of crosslinked hyaluronic acid into contact with a solution of free hyaluronic acid in order to obtain a lubricated hydrophobic support,, wherein the crosslinking agent is a water-soluble titanium chelate or zirconium chelate; and, wherein the crosslinking agent is a chelate of formula 1 below:, , where A is Ti, and, where R1 is a functional group containing an oxygen or nitrogen atom, R2 represents two or three carbon atoms, and R3 and R4 represent a linear or branched or cyclic C1-C4 alkyl.