Patent ID: 11896969
Assignee: BIO-RAD LABORATORIES, INC.
Field: Chemical engineering (Chemistry)
Classification: CPC B  C | IPC B  C

Claim 0:
1. A chromatography matrix covalently linked to a ligand having the following formula:
Chromatography matrix-(X)—N(R1)—(R2-L)n-Ar
or an anionic salt thereof,
wherein:
X is a spacer;
R1 is hydrogen or C1 to C6 alkyl optionally substituted with an —OH;
R2 is C2 to C6 alkyl or C4 to C6 cycloalkyl;
L is NR4, O, or S;
n=1 or 2; and
Ar is a 6-10 membered ring and:
if Ar is aryl, the aryl is optionally substituted with up to five C1 to C3 unsubstituted alkyl, C3 to C6 branched alkyl, unsubstituted aryl, or fluorine groups; or
if Ar is heteroaryl, the heteroaryl is optionally substituted with up to four unsubstituted alkyl groups,
with the proviso that when R1 is hydrogen, R2 is C2 alkyl, L is NR4 or O, and n is 1, Ar is not phenyl.