Patent ID: 11883470
Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 0:
1. A recombinant viral vector which comprises an expression cassette comprising:
(a) a nucleic acid sequence comprising SEQ ID NO: 26, SEQ ID NO: 63, or a sequence at least 95% identical to SEQ ID NO: 26 or 63 which encodes a functional human lecithin cholesterol acyltransferase (LCAT) variant comprising: an M amino acid substitution at amino acid residue position 114 based on the residue numbering of WT normal LCAT (V114M); and
(b) regulatory sequences which direct expression of the LCAT V114M in a host cell, said regulatory sequences being operably linked to the LCAT V114M sequence.