Patent ID: 11896671
Assignee: ASCENDIS PHARMA A/S
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A

Claim 12:
13. The compound of claim 10, wherein —X0 is of formula (III), wherein
the dashed line indicates attachment to -L2- or -L2′-, respectively;
—X1, —X2 and —X3 are independently of each other selected from the group consisting of —F, —OR, —N+R3, —N+R2OR, —N+R2SR and —N+R2NR2;
each —R is independently selected from the group consisting of —H, -T0, C1-50 alkyl, C2-50 alkenyl, and C2-50 alkynyl; wherein -T0, C1-50 alkyl, C2-50 alkenyl, and C2-50 alkynyl are optionally substituted with one or more —Rx1, which are the same or different and
wherein C1-50 alkyl, C2-50 alkenyl, and C2-50 alkynyl are optionally interrupted by one or more groups selected from the group consisting of -T0-, —C(O)O—, —O—, —C(O)—, —C(O)N(Rx2)—, —S(O)2N(Rx2)—, S(O)N(Rx2), —S(O)2—, —S(O)—, —N(Rx2)S(O)2N(Rx2a)—, —S—, —N(Rx2)—, —OC(ORx2)(Rx2a), —N(Rx2)C(O)N(Rx2a)—, and —OC(O)N(Rx2)—;
each T0 is independently selected from the group consisting of phenyl, naphthyl, indenyl, indanyl, tetralinyl, C3-10 cycloalkyl, 3- to 10-membered heterocyclyl, and 8- to 30-membered heteropolycyclyl; wherein each T0 is independently optionally substituted with one or more —Rx1, which are the same or different;
each —Rx1 is independently selected from the group consisting of halogen, -T0, —CN, oxo (═O), —COORx3, —ORx3, —C(O)Rx3, —C(O)N(Rx3Rx3a), —S(O)2N(Rx3Rx3a), —S(O)N(Rx3Rx3a), —S(O)2Rx3, —S(O)Rx3, —N(Rx3)S(O)2N(Rx3aRx3b), —SRx3, —N(Rx3Rx3a), —NO2, —OC(O)Rx3, —N(Rx3)C(O)Rx3a, —N(Rx3)S(O)2Rx3a, —N(Rx3)S(O)Rx3a, —N(Rx3)C(O)ORx3a, —N(Rx3)C(O)N(Rx3aRx3b), —OC(O)N(Rx3Rx3a), and C1-6 alkyl; wherein C1-6 alkyl is optionally substituted with one or more halogen, which are the same or different;
each —Rx2, —Rx2a, —Rx3, —Rx3a, Rx3b is independently selected from the group consisting of —H and C1-6 alkyl; wherein C1-6 alkyl is optionally substituted with one or more halogen, which are the same or different;
optionally, two or three of —X1, —X2 and —X3 are joined together with the atom to which they are attached to form a ring A0;
A0 is selected from the group consisting of 3- to 10-membered heterocyclyl and 8- to 30-membered heteropolycyclyl.