Patent ID: 11872250
Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 1:
2. A method of inducing an immune response comprising administering to a subject in need thereof an effective amount of a population of isolated trained mesenchymal stem cells prepared by a process comprising the steps of:
(i) obtaining multipotent progenitor cells;
(ii) culturing said multipotent progenitor cells in a medium;
(iii) separating mesenchymal stem cells from differentiated cells in said medium; and
(iv) activating at least a subset of said separated mesenchymal stem cells by exposing it to isolated IFNγ and an effective amount of at least one cytokine for inducing an immune response, the at least one cytokine selected from the group consisting of IL-1 α, IL-1 β, IFN-I α, IFN-I β, TNF α, TGF β, and FGF for a sufficient period of time such that the activated mesenchymal stem cells are immunomodulatory.