Patent ID: 11939323
Assignee: GLOBAL BLOOD THERAPEUTICS, INC.
Field: Organic fine chemistry (Chemistry)
Classification: CPC C | IPC C

Claim 0:
1. A process for preparing a compound of formula I:, comprising:
(i) contacting a compound of formula 1:, wherein X1 is halo;

with a metalating reagent and carbon dioxide, wherein the metalating agent is a compound of formula X-M-R, and wherein M is a metal, R is an alkyl or aryl, and X is a halide or alkali metal, to form a compound of formula 2a:, (ii) contacting a compound of formula 2a with a compound of formula:

PG-X2 

wherein PG is a hydroxy protecting group and X2 is halo;

to form a compound of formula 3:, (iii) contacting a compound of formula 3 with a compound of formula 4:, to form a compound of formula 5:, (iv) contacting a compound of formula 5 with a compound of formula 6:, to form a compound of formula 7:, , and
(v) deprotecting a compound of formula 7 to form a compound of formula I.