Patent ID: 11866726
Assignee: EDITAS MEDICINE, INC.
Field: Biotechnology (Chemistry)
Classification: CPC C | IPC C

Claim 1:
2. The isolated nucleic acid of claim 1, wherein:
(i) the first stuffer has a sequence having less than 50% sequence identity to any nucleic acid sequence within 500 base pairs of the cleavage site, and wherein the second stuffer has a sequence having less than 50% sequence identity to any nucleic acid sequence within 500 base pairs of the cleavage site;
(ii) the first stuffer has a sequence comprising at least 10 consecutive nucleotides of a sequence selected from the group consisting of SEQ ID NOs: 1-101, and wherein the second stuffer has a sequence comprising at least 10 consecutive nucleotides of a sequence selected from the group consisting of SEQ ID NOs: 1-101; or
(iii) the first stuffer has a sequence that is not the same as the sequence of the second stuff.