Patent ID: 11944680
Assignee: MYELOID THERAPEUTICS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A

Claim 7:
8. A composition comprising a recombinant polynucleic acid encapsulated by a nanoparticle delivery vehicle, wherein the recombinant polynucleic acid comprises a sequence encoding a chimeric fusion protein (CFP), the CFP comprising:
(a) an extracellular domain comprising an anti-TROP2 binding domain, and
(b) a transmembrane domain operatively linked to the extracellular domain;
wherein the CFP is expressed on the surface of myeloid cells that express endogenous FcR-gamma receptors, wherein the transmembrane domain is a transmembrane domain from CD16a, CD64, CD68 or CD89, and wherein the transmembrane domain from CD89 comprises an amino acid sequence of LIRMAVAGLVLVALLAILV (SEQ ID NO: 83).