Patent ID: 11884677
Assignee: KING FAISAL UNIVERSITY
Field: Organic fine chemistry (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 9:
10. A method of preparing a compound having the formula 4:, , the method comprising:
mixing equimolar amounts of a substituted aromatic aldehyde having the formula 1, a substituted barbituric acid derivative having the formula 2, and a guanidine hydrochloride having the formula 3 to obtain a first mixture;
adding a mixture of water and ethanol along with a catalytic amount of Ceric Ammonium Nitrate to the first mixture to obtain a reaction mixture;
stirring the reaction mixture until reaction completion; and
filtering, washing with aqueous ethanol, and purifying the compound of formula 4, wherein the reaction occurs according to the following formula:, , wherein:
R1 is selected from the group consisting of hydrogen, hydroxy, and benzyloxy;
R2 is selected from the group consisting of hydrogen, a C1-C6 straight or branched chain alkoxy, and benzyloxy;
R3 is selected from the group consisting of hydrogen and a C1-C6 straight or branched chain alkyl;
R4 is selected from the group consisting of hydrogen and a C1-C6 straight or branched chain alkyl; and
Y is oxygen.