Patent ID: 11964986
Assignee: REJUVERON TELOMERE THERAPEUTICS AG
Field: Organic fine chemistry (Chemistry)
Classification: CPC C  A | IPC C

Claim 0:
1. A compound of formula (I), or a pharmaceutically acceptable salt, a racemic mixture, a corresponding enantiomer or, if applicable, a corresponding diastereomer thereof,
wherein
R1 is selected from the group consisting of hydrogen, a linear or branched C1 to C6 alkyl, a C3 to C5 cycloalkyl, a C1-C3-alkyl-C3-C5-cycloalkyl, and a cyclic ether comprising 4 to 5 ring atoms,
wherein said C1 to C6 linear or branched alkyl is optionally substituted with one or more substituents selected from the group consisting of fluoro, chloro, hydroxy and C1 to C3 alkoxy,
wherein said C3 to C5 cycloalkyl and said C1-C3-alkyl-C3-C5-cycloalkyl may optionally be substituted with one or more substituents selected from the group consisting of fluoro, chloro, C1 to C3 alkyl, hydroxy and C1 to C3 alkoxy, and
wherein said cyclic ether comprising 4 to 5 ring atoms is optionally substituted with one or more substituents selected from the group consisting of fluoro, chloro, C1 to C3 alkyl, hydroxy and C1 to C3 alkoxy;

R2 is selected from the group consisting of hydrogen and methyl;
R3 is selected from the group consisting of hydrogen, a linear or branched C1 to C6 alkyl, a C3 to C6 cycloalkyl, a 4-6-membered heterocycloalkyl, C1-C3-alkyl-C3-C6-cycloalkyl and a C1-C3-alkyl-4-6-membered heterocycloalkyl,
wherein said linear or branched C1 to C6 alkyl may optionally be substituted with one or more substituents selected from the group consisting of fluoro, chloro, cyano, hydroxy and C1 to C3 alkoxy, and
wherein said C3 to C6 cycloalkyl, said 4-6-membered heterocycloalkyl, said C1-C3-alkyl-C3-C6-cycloalkyl and said C1-C3-alkyl-4-6-membered heterocycloalkyl may optionally be substituted with one or more substituents selected from the group consisting of fluoro, chloro, cyano, C1 to C3 alkyl, hydroxy and C1 to C3 alkoxy; or

R2 and R3 may form together a 4 to 6 membered cycloalkyl or heterocycloalkyl, which may optionally be substituted with one or more substituents selected from the group consisting of fluoro, chloro, cyano, C1 to C3 alkyl, hydroxy and C1 to C3 alkoxy;
R4 is selected from the group consisting of a linear or branched C1 to C6 alkoxy, an alkoxyalkoxyl group having up to 6 carbon atoms, a C1-C3 alkoxy C3-C8 cycloalkyl, a 4-7-membered heterocycloalkyl, a C1-C6 alkyl 4-7 membered monocyclic heterocycloalkyl, a C2 to C8 alkenyl and a C2 to C8 alkynyl,
wherein said C1 to C6 alkoxy, said alkenyl and said alkynyl may optionally be substituted with one or more substituents selected from the group consisting of hydroxy, chloro and fluoro, a 3 to 6 membered monocyclic cycloalkyl group, a 4 to 6 membered monocyclic heterocycloalkyl group, a spirocyclic 3 to 7 membered monocyclic cycloalkyl group and a spirocyclic 3 to 7 membered monocyclic heterocycloalkyl group, and
wherein said C1-C3 alkoxy C3-C8 cycloalkyl, said 4-7-membered heterocycloalkyl, and said C1-C6 alkyl 4-7 membered monocyclic heterocycloalkyl may optionally be substituted with one or more substituents selected from the group consisting of hydroxy, chloro, fluoro, and C1 to C3 alkyl and C1 to C3 alkoxy; and

R5 is selected from the group consisting of fluoro, chloro, bromo, cyano, C1 to C5 alkoxy, C1 to C5 alkyl, alkoxyalkyl having up to 6 carbon atoms, 4 to 6 membered heterocycloalkyl, 3 to 6 membered cycloalkyl, 5-membered heteroaryl, and NR6R7,
wherein said C1 to C5 alkoxy and said alkoxyalkyl having up to 6 carbon atoms may optionally be substituted with one or more substituents selected from the group consisting of fluoro, chloro, hydroxy, C1 to C3 alkoxy,
wherein said C1 to C5 alkyl is optionally substituted with one or more substituents selected from the group consisting of fluoro, chloro, C1 to C3 alkoxy, 3 to 6 membered cycloalkyl and 4 to 6 membered heterocycloalkyl,
wherein said 4 to 6 membered heterocycloalkyl is optionally substituted with one or more substituents selected from the group consisting of fluoro, chloro, hydroxy, C1 to C3 alkoxy, and C1 to C3 alkyl,
wherein said 3 to 6 membered cycloalkyl is optionally substituted one or more substituents selected from the group consisting of with fluoro, chloro, hydroxy, C1 to C3 alkoxy, and C1 to C3alkyl,
wherein R6 and R7 are independently selected from the group consisting of hydrogen, methyl and ethyl, and
wherein said 5-membered heteroaryl is optionally substituted with one or more substituents selected from the group consisting of fluoro, chloro, hydroxy, C1 to C3 alkoxy, and C1 to C3 alkyl.