Patent ID: 11873309
Assignee: INCYTE CORPORATION
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC C

Claim 12:
13. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein:
(i) G1 is NR6 and G2 is CR7R7; or
(ii) G1 is CR6R6 and G2 is NR7;
X1 is N or CR1;
X2 is N or CR2;
X3 is N or CR3;
R1 is H, R2 is H or halo, and R3 is H;
R4 is H or C1-6 alkyl;
each R5 is H;
R6, R7 and R8 are each independently selected from H, halo, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C1-6 haloalkoxy, CN, NO2, ORa, and C(O)ORa, wherein the C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl of R6, R7 and R8 are each optionally substituted with 1 or 2 Rb substituents;
or two adjacent R8 substituents on the Cy ring, taken together with the atoms to which they are attached, form a fused 5-, 6- or 7-membered heterocycloalkyl ring, or a fused 5- or 6-membered heteroaryl ring, wherein the fused 5-, 6- or 7-membered heterocycloalkyl ring and fused 5- or 6-membered heteroaryl ring each have 1-4 heteroatoms as ring members selected from N, O and S and wherein the fused 5-, 6- or 7-membered heterocycloalkyl ring and fused 5- or 6-membered heteroaryl ring are each optionally substituted with 1 or 2 independently selected Rb substituents;
R9 is halo, C1-6 alkyl, or CN;
each Ra is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, and C2-6 alkynyl;
each Rb substituent is independently selected from halo, C1-6 alkyl, C1-6 haloalkyl, C1-6 haloalkoxy, CN, OH, NH2, ORc, C(O)Rc, C(O)NRcRc, and C(O)ORc;
each Rc is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, and C2-6 alkynyl; and
the subscript n is an integer of 1 or 2.