Patent ID: 11883246
Assignee: BOSTON MEDICAL CENTER CORPORATION
Field: Medical technology (Instruments)
Classification: CPC A | IPC A

Claim 20:
21. A method comprising:
Implanting, without the use of adhesives, into a target tissue at a target site a tissue marker having a flexible polymer matrix, the flexible polymer matrix comprises a sheet, wherein the sheet when in a substantially planar configuration comprises at least two films with one or more contrast agents located between the surfaces of the at least two films, such that the tissue marker is visible by one or more imaging modalities, wherein the flexible polymer matrix is implanted into the tissue in a rolled configuration as a hollow cylinder, wherein the target tissue is a soft tissue selected from the group consisting of breast tissue, colon tissue, rectal tissue, liver tissue, ovarian tissue, prostate tissue, and lung tissue, and wherein the flexible polymer matrix comprises macropores and wherein a density of the flexible polymer matrix and the target tissue differs by no more than 30%, and wherein upon the implantation at the target site, the flexible polymer matrix at least partially unrolls to form a planar shape or partially unrolled cylinder while maintaining the density for a period of at least 60 seconds thereby preventing the tissue marker from migrating more than 10 mm from the target site over a period of at least one month, and
growing a plurality of cells into the macropores.