Patent ID: 11879011
Assignee: BIOATLA, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C  G | IPC A  C

Claim 0:
1. A human or humanized antibody or antibody fragment that specifically binds to ROR2 protein, said antibody or antibody fragment comprising
a heavy chain variable region including three complementarity determining regions having H1, H2, and H3 sequences, wherein:, (a) the H1 sequence is

(SEQ ID NO: 1)

GYTX1TEX2X3X4H;

 

(b) the H2 sequence is

(SEQ ID NO: 2)

X5X6X7X8NNGGTGYNQKFKG;

and

 

(c) the H3 sequence is

(SEQ ID NO: 3)

X9X10X11SX12YX13YX14X15SYFX16X17X18;, wherein X1 is F or E,, X2 is Y or D,, X3 is T or C,, X4 is M or D or E or Y,, X5 is G or S,, X6 is I or E,, X7 is N or C or L or V,, X8 is T or D or E,, X9 is A or I or M or S or T,, X10 is R or Q or H,, X1 is G,, X12 is L,, X13 is S,, X14 is G,, X15 is N or E,, X16 is D or L,, X17 is Y or T, and, X18 is W or L, and
a light chain variable region including three complementarity determining regions having L1, L2, and L3 sequences, wherein:, (a) the L1 sequence is

(SEQ ID NO: 7)

SATSSX19X20X21MX22;

 

(b) L2 sequence is

(SEQ ID NO: 8)

X23TSNLAS;

and

 

(c) L3 sequence is

(SEQ ID NO: 9)

QX24X25SX26YPFX27X28;, Wherein X19 is V or E,, X20 is S or D,, X21 is Y or C or D,, X22 is H or G or L,, X23 is G or C or H or P,, X24 is Q or E,, X25 is R or H,, X26 is S or G or I or Q,, X27 is T or D, and, X28 is F or D or E; and, wherein the antibody or antibody fragment has only one single point mutation in one of the heavy and light chain complementarity determining regions H1, H2, H3, L1, L2 and L3, said one single point mutation being determined in comparison with the parent polypeptide in which X1 to X28 are F, Y, T, M, G, I, N, T, A, R, G, L, S, G, N, D, Y, W, V, S, Y, H, G, Q, R, S, T, and F, respectively.