Patent ID: 11964024
Assignee: MERSANA THERAPEUTICS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 10:
11. The B7-H4 antibody-drug conjugate of claim 9, wherein the B7-H4 antibody-drug conjugate is, wherein:
d13 is from about 2 to about 12;
Y1, Y2, Z1 and Z2 are each independently O, S, C or N;
X1, X2, W1 and W2 are each independently C or N;
X3 and X4 are each independently S or NRf;
X6 is N or CRA1;
X7 is N or CR4;
Rc is C1-4 alkyl;
RA1, and R4 are each independently H, halogen, hydroxy, amino, amino(C1-4 alkyl)-, optionally substituted (C1-6 alkyl), or optionally substituted (C1-6 alkyl)oxy-, wherein C1-6 alkyl of said optionally substituted (C1-6 alkyl), or optionally substituted (C1-6 alkyl)oxy- is optionally substituted with 1-4 substituents each independently selected from the group comprising hydroxyl, C1-4 alkoxyl, —N(Re)(Rf), —CO2(Rf), —CON(Re)(Rf), and —COOH;
each Rd is independently H, hydroxy, or C1-4 alkyl;
Re is selected from H, (C1-4 alkyl), -CO(C1-4 alkyl), —OCO(C1-4 alkyl), and -CO2(C1-4 alkyl);
each Rf is independently H, hydroxy, or (C1-4 alkyl);
R14 and RC2 are each independently absent or C1-4 alkyl, wherein C1-4 alkyl is optionally substituted by a substituent selected from halogen, —ORc, —NRcRd, -CO2Rc, —CONRcRd, —SO2NRcRd, and —OCONRcRd;
R16 and RC1 are each independently absent, H or C1-4 alkyl; and
R15, R17, R18, or R19 are each independently absent, H, or C1-4 alkyl, wherein C1-4 alkyl is optionally substituted by a substituent selected from halogen, —ORc, —NRcRd, -CO2Rc, —CONRcRd, —SO2NRcRd, and —OCONRcRd.