Patent ID: 11964996
Assignee: JIYUE ZHENG
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC C

Claim 4:
5. The 2-alkynylmannose derivative, a pharmaceutically acceptable salt, or an isotope thereof according to claim 1, having a structure shown as formula Ia:, where,
R4 is selected from a hydrogen atom, a deuterium atom, a halogen, cyano, C1-8 alkyl, C3-8 cycloalkyl, and C1-8 alkoxy, and the alkyl, the cycloalkyl, and the alkoxy are unsubstituted or substituted with 1 to 3 substituent groups selected from a deuterium atom, a halogen, hydroxyl, cyano, C1-3 alkyl, C3-5 cycloalkyl, and C1-3 alkoxy;
U is a hydrogen atom, a deuterium atom, C1-10 alkyl, C3-10 cycloalkyl, a six- to ten-membered aromatic ring, a five- to ten-membered heteroaromatic ring that contains 1 to 4 heteroatoms selected from N, O, and S, or a five- to seven-membered heterocyclic ring that contains 1 or 2 heteroatoms selected from N, O, and S, and the alkyl, the cycloalkyl, the aromatic ring, the heteroaromatic ring, and the heterocyclic ring are unsubstituted or substituted with 1 to 5 R1 groups; and
Z is selected from a hydrogen atom, a deuterium atom, a halogen, cyano, C1-10 alkyl, C3-10 cycloalkyl, C1-10 alkoxy, C2-8 alkenyl, C2-8 alkynyl, —C(O)OR5, —C(O)NR5R6, —N(R5)C(O)R6, —S(O)2R5, —S(O)2NR5R6, —P(O)R5R6, a six- to ten-membered aromatic ring, a five- to fourteen-membered heteroaromatic ring that contains 1 to 4 heteroatoms selected from N, O, and S, or a five- to ten-membered heterocyclic ring that contains 1 or 2 heteroatoms selected from N, O, and S, and the alkyl, the cycloalkyl, the alkenyl, the alkynyl, the aromatic ring, the heteroaromatic ring, and the heterocyclic ring are unsubstituted or substituted with 1 to 5 R7 groups.