Patent ID: 11879123
Assignee: SYNLOGIC OPERATING COMPANY, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 17:
18. The bacterium of claim 17, wherein:
the promoter operably linked to the three copies of the gene encoding PAL derived from Photorhabdus luminescens is inducible under anaerobic or low-oxygen conditions;
the promoter operably linked to the two additional copies of the gene encoding PAL derived from Photorhabdus luminescens is an IPTG-inducible promoter;
the promoter operably linked to the two copies of the non-native gene encoding the phenylalanine transporter derived from Escherichia coli is inducible under anaerobic or low-oxygen conditions;
the promoter operably linked to the one copy of the gene encoding LAAD derived from Proteus mirabilis is an arabinose-inducible promoter; and
the mutation in one or more of ThyA or DapA is a mutation in the DapA gene.