Patent ID: 11857623
Assignee: KING ABDULAZIZ UNIVERSITY
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A

Claim 3:
4. A method for making the protein construct of claim 1, comprising:
computer modelling of scaffold proteins of the extracellular adherence protein (EAP) domain of Staphylococcus aureus that is EAP IYN3 chain A of SEQ ID NO: 5 when modified by insertion of an IgE motif comprising an FG loop (SEQ ID NO: 2),
redesigning the portion of the scaffold containing the FG loop so that it folds in a way to present the FG loop to the immune system thereby describing structure of the protein construct;
synthesizing DNA encoding the protein construct, and expressing the DNA in a suitable host cell, thereby producing the protein construct;
wherein the construct is any one of those of SEQ ID NOS: 7-16.