Patent ID: 11944644
Assignee: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 13:
14. A DNA construct encoding an amino acid sequence selected from the group consisting of:
(A) from 5′ to 3′, (i) a leader peptide, (ii) anti-CD138 scFv, (iii) a transmembrane domain I, (iv) a costimulatory domain or; an activation domain, (v) a self-cleaving peptide, (vi) a leader peptide, (vii) anti-CD38 scFv domain, (viii) a transmembrane domain II, and (ix) a costimulatory domain or an activation domain;
(B) from 5′ to 3′, (i) a leader peptide, (ii) anti-CD38 scFv domain, (iii) a transmembrane domain II, (iv) an activation domain or a costimulatory domain, (v) a self-cleaving peptide, (vi) a leader peptide, (vii) anti-CD138 scFv, (viii) a transmembrane domain I, and (ix) a costimulatory domain or an activation domain;
(C) from 5′ to 3′, (i) a leader peptide, (ii) anti-CD138 scFv, (iii) a transmembrane domain I, (iv) a costimulatory domain, (v) a self-cleaving peptide, (vi) a leader peptide, (vii) anti-CD38 scFv domain, (viii) a transmembrane domain II, and (ix) an activation domain; and
(D) from 5′ to 3′, (i) a leader peptide, (ii) anti-CD38 scFv, (iii) a transmembrane domain II (iv) an activation domain, (v) a self-cleaving peptide, (vi) a leader peptide, (vii) anti-CD138 scFv domain, (viii) a transmembrane domain I, and (ix) a costimulatory domain.