Patent ID: 11957673
Assignee: AUGUSTA UNIVERSITY RESEARCH INSTITUTE, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 2:
3. A compound according to Formula III:, , or a pharmaceutically acceptable enantiomer, or salt thereof, wherein:
R1 is (C1-C30)-alkyl, —(C3-C12)-cycloalkyl, —(C3-C12)-heterocycloalkyl, —(C6-C20)-aryl, or —(C3-C20)-heteroaryl groups optionally substituted by one or more substituents selected from —(C1-C12)-alkyl, —(C3-C12)-cycloalkyl, —(C3-C12)-heterocycloalkyl, —O—(C1-C12)-alkyl, —O—(C3-C12)-cycloalkyl, —S—(C1-C12)-alkyl, —S—(C3-C12)-cycloalkyl, —COO—(C1-C12)-alkyl, —COO—(C3-C12)-cycloalkyl, —CONH—(C1-C12)-alkyl, —CONH—(C3-C12)-cycloalkyl, —CO—(C1-C12)-alkyl, —CO—(C3-C12)-cycloalkyl, —N—[(C1-C12)-alkyl]2, —COOH, —OH, —SH, —SO3H, —CN, —NH2, or a halogen;
X, Y, and Z are independently —O, —NH, —S, or —N—(C1-C30)-alkyl;
R2 is ═O, —OH, —SO2, —SO, or —SOCH3; and
R4 is selected from —(C1-C12)-alkyl, —(C3-C12)-cycloalkyl, —(C3-C12)-heterocycloalkyl, —O—(C1-C12)-alkyl, —O—(C3-C12)-cycloalkyl, —S—(C1-C12)-alkyl, —S —(C3-C12)-cycloalkyl, —COO—(C1-C12)-alkyl, —COO—(C3-C12)-cycloalkyl, —CONH—(C1-C12)-alkyl, —CONH—(C3-C12)-cycloalkyl, —CO—(C1-C12)-alkyl, —CO—(C3-C12)-cycloalkyl, —N—[(C1-C12)-alkyl]2, —(C6-C20)-aryl, —(C6-C20)-aryl-(C1-C12)-alkyl, —(C3-C20)-heteroaryl, —(C3-C20)-heteroaryl-(C1-C12)-alkyl, —COOH, —OH, —SH, —SO3H, —CN, —NH2, or a halogen,
with the proviso that:
when R1 is unsubstituted pyridine, N-substituted pyridine by —(C1-C3)-alkyl, or pyrimidine substituted by —(C1)-alkyl and —NH2, X, Y, Z are —NH, R2 is ═O, then R4 is not halogen, not —(C1)-alkyl, not —O—(C1)-alkyl, not —NH2, not —CN, not —COOH, and not —N—[(C1)-alkyl]2.