Patent ID: 11866469
Assignee: KLOGENIX LLC
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A method of increasing expression of a Klotho gene in a cell the method comprising administering to the cell a DNA binding protein comprising or attached to a transcriptional activation domain wherein the DNA binding protein binds to a target sequence within or near the Klotho gene and thereby increases expression of the Klotho gene, wherein the DNA binding protein is a zinc finger protein comprising:
a ZF1 zinc finger comprising the sequence set forth in SEQ ID NO 8, a ZF2 zinc finger comprising the sequence set forth in SEQ ID NO 16, a ZF3 zinc finger comprising the sequence set forth in SEQ ID NO 18, a ZF4 zinc finger comprising the sequence set forth in SEQ ID NO. 16, a ZF5 zinc finger comprising the sequence set forth in SEQ ID NO 3, a ZF6 zinc finger comprising the sequence set forth in SEQ ID NO 8 and a ZF7 zinc finger comprising the sequence set forth in SEQ ID NO 3.