Patent ID: 11896671
Assignee: ASCENDIS PHARMA A/S
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A

Claim 2:
3. The compound of claim 2, wherein -L1- is of formula (a-i):, wherein
the dashed line indicates the attachment to a primary or secondary amine of -D by forming an amide bond;
—X— is —C(R4R4a)—; —N(R4)—; —O—; —C(R4R4a)—C(R5R5a)—; —C(R5R5a)—C(R4R4a)—; —C(R4R4a)—N(R6)—; —N(R6)—C(R4R4a)—; —C(R4R4a)—O—; —O—C(R4R4a)—; or —C(R7R7a)—;
>X1═ is C; or S(O);
—X2— is —C(R8R8a)— or —C(R8R8a)—C(R9R9a)—;
═X3 is ═O; ═S; or ═N—CN;
—R1, —R1a, —R2, —R2a, —R4, —R4a, —R5, —R5a, —R6, —R8, —R8a, —R9, —R9a are independently selected from the group consisting of —H and C1-6 alkyl;
—R3, —R3a are independently selected from the group consisting of —H and C1-6 alkyl, provided that in case one of —R3, —R3a or both are other than —H they are connected to N to which they are attached through a sp3-hybridized carbon atom;
—R7 is —N(R10R10a); or —NR10—(C═O)—R11;
—R7a, —R10, —R10a, —R11 are independently of each other —H; or C1-6 alkyl;
optionally, one or more of the pairs —R1a/—R4a, —R1a/—R5a, —R1a/—R7a, —R4a/—R5a, —R8a/R9a form a chemical bond;
optionally, one or more of the pairs —R/—R1a, —R2/—R2a, —R4/—R4a, —R5/—R5a, —R8/—R8a, —R9/—R9a are joined together with the atom to which they are attached to form a C3-10 cycloalkyl; or 3- to 10-membered heterocyclyl;
optionally, one or more of the pairs —R1/—R4, —R1/—R5, —R1/—R6, —R1/—R7a, —R4/—R5, —R4/—R6, —R8/—R9, —R2/—R3 are joined together with the atoms to which they are attached to form a ring A0;
optionally, R3/R3a are joined together with the nitrogen atom to which they are attached to form a 3- to 10-membered heterocycle;
A0 is selected from the group consisting of phenyl; naphthyl; indenyl; indanyl; tetralinyl; C3-10 cycloalkyl; 3- to 10-membered heterocyclyl; and 8- to 11-membered heterobicyclyl; and
wherein -L1- is substituted with 1, 2, 3, 4, 5, 6, 7 or 8 moieties of -L2-A and wherein -L1- is optionally further substituted, provided that the hydrogen marked with the asterisk in formula (a-i) is not replaced by -L2-A or a substituent.