Patent ID: 11952376
Assignee: PLIANT THERAPEUTICS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 158:
159. A method for treating an individual having one or more tissues in need of therapy, wherein the method comprises administering to the individual in need thereof a therapeutically effective amount of a compound of claim 1, or a pharmaceutically acceptable salt, stereoisomer, or tautomer thereof;
wherein when compared to a healthy state of the one or more tissues, the one or more tissues have at least one elevated level of:
(a) transforming growth factor beta (TGFβ) activation; or
(b) transforming growth factor beta (TGFβ) expression; or
(c) both transforming growth factor beta (TGFβ) activation and transforming growth factor beta (TGFβ) expression; or
(d) αvβ1 integrin activity; or
(e) αvβ1 integrin expression; or
(f) both αvβ1 integrin activity and αvβ1 integrin expression; or
(g) αvβ6 integrin activity; or
(h) αvβ6 integrin expression; or
(i) both αvβ6 integrin activity and αvβ6 integrin expression.