Patent ID: 11884732
Assignee: DRAGONFLY THERAPEUTICS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A protein comprising:
(a) a first antigen-binding site that binds NKG2D;
(b) a second antigen-binding site that binds HER2; and
(c) a first antibody Fc domain of human IgG1 or a portion thereof and a second antibody Fc domain of human IgG1 or a portion thereof that together are sufficient to bind CD16, wherein the first antibody Fc domain or the portion thereof and the second antibody Fc domain or the portion thereof comprise different amino acid mutations to promote heterodimerization,
wherein the first antigen-binding site comprises a heavy chain variable domain comprising the amino acid sequence of SEQ ID NO:1 and a light chain variable domain comprising the amino acid sequence of SEQ ID NO:2.