Patent ID: 11931456
Assignee: MEGAPRO BIOMEDICAL CO. LTD.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 0:
1. A method of preparing a pharmaceutical composition comprising a mixed polymeric micelle having a size of 1 to 1000 nm and a drug enclosed in said micelle, the method comprising:
providing starting materials including an amphiphilic block copolymer, a lipopolymer, and a drug;
mixing the starting materials in a solvent;
removing the solvent to afford a dry film or a dry cake;
adding water to solubilize the dry film or the dry cake to form a solution containing a mixed polymeric micelle; and
filtering the solution to provide a pharmaceutical composition,, wherein the amphiphilic block copolymer is methoxypolyethylene glycol-polycaprolactone (mPEG-PCL), the lipopolymer is 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-methoxy poly(ethylene glycol) (PEG-DSPE), the lipopolymer is not conjugated with a ligand, and the drug is cabazitaxel.