Patent ID: 11919206
Assignee: FRAUNHOFER GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
Field: Other special machines (Mechanical engineering)
Classification: CPC B  C | IPC B  C

Claim 0:
1. A method for producing a matrix for cultivating biological cells and differentiating the biological cells into neuronal cells or neuronal tissue, the matrix comprising a base body made of biocompatible or biological polymer having a structured surface, a first periodic microstructure made of parallel microdimensioned grooves, and a second periodic nanostructure, the second periodic nanostructure made of parallel nanodimensioned grooves, and the second periodic nanostructure extending parallel to the first periodic microstructure and embedded into the parallel microdimensioned grooves of the first periodic microstructure, the method comprising:
forming a structured surface on a tool by machining, wherein the machining is performed with a machining tool having a cutting edge made of monocrystalline diamond with a tip radius of 10 μm or less and the first periodic microstructure and the second periodic nanostructure embedded therein are formed as a negative mold, and
producing the structured surface on the base body made of biocompatible or biological polymer by:
casting the polymer of the base body onto the tool, or,
embossing of the polymer of the base body with the tool, and

drying the polymer of the base body on the tool and separating the dry base body from the tool,
wherein the matrix is obtained as the base body having a structured surface.