Patent ID: 11866700
Assignee: EXICURE OPERATING COMPANY
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 0:
1. A multiplex antisense oligonucleotide spherical nucleic acid (mASO-SNA), comprising
a core having an oligonucleotide shell comprised of an antisense oligonucleotide 10 to 30 linked nucleosides in length targeted to a first gene and an antisense oligonucleotide 10 to 30 linked nucleosides in length targeted to a second gene, wherein the core is a liposome core and the oligonucleotide shell is positioned on the exterior of the core,
wherein each antisense oligonucleotide comprises at least two modified nucleosides,
wherein each antisense oligonucleotide further comprises a molecular species at the 5′ end, 3′ end, or 5′ and 3′ end of the antisense oligonucleotide,
wherein the molecular species is a lipid moiety connected to the antisense oligonucleotide by a linker, wherein the linker comprises hexaethylene glycol.