Patent ID: 11890261
Assignee: ADAMAS PHARMACEUTICALS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 0:
1. A method of treating a drug-induced extrapyramidal reaction in an adult patient, comprising administering to the patient a pharmaceutical composition comprising:
i) amantadine or a pharmaceutically acceptable salt thereof in an extended release form, and
ii) amantadine or a pharmaceutically acceptable salt thereof in an immediate release form,
wherein the composition comprises about 129 mg of amantadine free base equivalent and has an in vitro dissolution profile of about 35% in about 30 minutes, about 35% in about 1 hour, about 40% in about 1.5 hours, and no more than about 45% in about 2 hours, as measured in 5% (v/v) ethanol in 0.1N HCl using a USP type II (paddle) dissolution system at 50 rpm, at a temperature of 37±0.5° C., wherein the in vitro dissolution profile is such that the composition does not dose dump in ethanol solutions containing up to 40% ethanol.