Patent ID: 11866504
Assignee: PETER MACCALLUM CANCER INSTITUTE
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A method of treating a solid tumor in a subject, the method comprising:
administering to a subject in need thereof:
(i) an immune cell expressing a chimeric antigen receptor (CAR) that binds to an antigen on the tumor; and
(ii) a bispecific polypeptide comprising a 1st binding domain and a 2nd binding domain, wherein the 1st binding domain specifically binds to an antigen expressed on an endogenous professional antigen presenting cell (APC) of the subject, wherein the endogenous professional APC is not a tumor cell; and wherein the 2nd binding domain specifically binds to an affinity tag on the CAR of the immune cell,

thereby treating the solid tumor in the subject,
wherein the antigen expressed on said endogenous professional antigen presenting cell is:
(i) not an antigen on the tumor;
(ii) not an antigen that is a tumor-associated antigen on the tumor; or
(iii) not differentially expressed by the tumor compared to a non-tumor cell of the same tissue type.