Patent ID: 11858991
Assignee: MACROGENICS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 15:
16. The method of claim 15, wherein said Fc Region is a variant Fc Region that comprises:
(a) one or more amino acid modifications that reduce(s) the affinity of said variant Fc Region for an FcγR, wherein said modifications comprise the substitutions:
(1) L234A;
(2) L235A; or
(3) L234A and L235A; and/or

(b) one or more amino acid modifications that enhance(s) the serum half-life of said variant Fc Region, wherein said modifications comprise the substitutions:
(1) M252Y and S254T;
(2) M252Y and T256E;
(3) M252Y, S254T and T256E; or
(4) K288D and H435K;

wherein said numbering is that of the EU index according to Kabat.