Patent ID: 11944641
Assignee: LPOXY THERAPEUTICS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C  Y | IPC A  C

Claim 13:
14. A method for the treatment of inflammation of the gastrointestinal tract, the method comprising:
oxygenating the gastrointestinal tract of a subject by administering to the gastrointestinal tract a formulation comprising:
an agent, a catalyst, a first controlled release coating encasing the agent, a second controlled release coating encasing the catalyst and the encased agent, a porous cellulose membrane that encapsulates the catalyst and the encased agent, and an enteric coating surrounding the oral formulation,
wherein the agent comprises sodium percarbonate or carbamide peroxide,
wherein the catalyst comprises catalase,
wherein the catalase controls the rate of conversion of the agent to oxygen,
wherein the porous cellulose membrane comprises two or more layers of cellulose having a functional pore size smaller than an actual pore size, wherein the actual pore size restricts diffusion of molecules greater than 10 kilodaltons, which thereby prevents a majority of the catalase from diffusing across the membrane,
wherein the pore size is sufficient to allow water to diffuse across any portion of the membrane to contact the agent and to allow oxygen to diffuse across any portion of the membrane into an intestine of the subject,
wherein when within the gastrointestinal tract of the subject, the catalase acts on the agent to generate a concentration of 2-5% oxygen in at least a portion of the gastrointestinal tract for 24 hours or more and thereby alleviate inflammation of the gastrointestinal tract, and
wherein the formulation is in a solid form as a pill or a capsule.