Patent ID: 11857571
Assignee: TRUSTEES OF DARTMOUTH COLLEGE
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 15:
16. A polynucleotide encoding an anti-major histocompatibility complex class I chain-related gene A (MICA) chimeric antigen receptor (CAR) comprising
an scFv comprising
a heavy chain variable region comprising the heavy chain complementarity determining regions 1, 2 and 3 (HCDR1, HCDR2 and HCDR3) respectively comprising the amino acid sequences of SEQ ID NO: 35; SEQ ID NO: 36; and SEQ ID NO: 22;
a flexible linker comprising the amino acid sequence set forth in SEQ ID NO: 51; and
and a light chain variable region comprising the light chain complementarity determining regions 1, 2 and 3 (LCDR1, LCDR2 and LCDR3) respectively comprising the amino acid sequences of SEQ ID NO: 26, SEQ ID NO: 28; and SEQ ID NO: 37;

a CD28 transmembrane domain;
a CD28 intracellular signaling domain; and
a CD3-zeta (CD3ζ) signaling domain.