Patent ID: 11944689
Assignee: SEAGEN INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 13:
14. The Ligand Drug Conjugate compound of claim 12 wherein the compound is represented by the structure of:, in pharmaceutically acceptable salt form(s), wherein
subscript a is 1, so that A is present, wherein A is an alpha-amino, beta-amino or another amine-containing acid residue;
Ra3 is —H or C1-C4 alkyl;
R2A is C(═O)CH3, —CH2CH3, —CH2CH═CH2 or —CH2C(═CH2)CH3;
R34 is isopropyl;
R35 is methyl or —(CH2)3NH(C═O)NH2; and
wherein the basic nitrogen atom bonded to Ra3 is optionally protonated,, or
wherein the compound is represented by the structure of:, in pharmaceutically acceptable salt form(s), wherein
subscript a is 1, so that A is present, wherein A is an alpha-amino, beta-amino or another amine-containing acid residue;
Ra3 is —H or C1-C4 alkyl;
R2A is —C(═O)CH3, —CH2CH3, —CH2CH═CH2 or —CH2C(═CH2)CH3; and
wherein the basic nitrogen atom bonded to Ra3 is optionally protonated.