Patent ID: 11970493
Assignee: ILDONG PHARMACEUTICAL CO., LTD.
Field: Organic fine chemistry (Chemistry)
Classification: CPC C | IPC C

Claim 36:
37. A compound of formula (III):, , or a pharmaceutically acceptable salt or isomer thereof,, wherein:
X1, X2, and X3 are independently selected from C—R1 and N;
Z1, Z2, and Z3 are independently selected from C—R1 and N;
each R1 is independently selected from —H, -halogen, optionally substituted —(C1-C6)alkyl and optionally substituted —(C1-C6)alkoxy;
Y is selected from S, O, and N—R2, wherein R2 is selected from —H, and optionally substituted —(C1-C6)alkyl;
R3a is selected from optionally substituted R4—C(O)—(C1-C3)alkyl-, R4C(O)—, halogen, optionally substituted monocyclic or bicyclic carbocycle, optionally substituted monocyclic or bicyclic heterocycle, R5R6HC—, and R5R6N—;
R4 is selected from H2N—, HO—, R5R6N—, optionally substituted (C1-C10)alkyl-, optionally substituted (C1-C10)alkoxy-, optionally substituted monocyclic or bicyclic carbocycle, optionally substituted monocyclic or bicyclic heterocycle, optionally substituted cycloalkyl-(C1-C6)alkylene-, and optionally substituted heterocycle-(C1-C6)alkylene-;
R5 and R6 are independently selected from H—, H2N—, HO—, optionally substituted (C1-C10)alkyl-, optionally substituted monocyclic or bicyclic carbocycle, optionally substituted monocyclic or bicyclic heterocycle, optionally substituted R4C(O)—(C1-C10)alkyl-, R4C(O)—, R4-, and substituted amino;
or R5 and R6 together with the nitrogen or carbon atom to which they are attached are cyclically linked to form an optionally substituted carbocycle or an optionally substituted heterocycle;
R7 is selected from H—, and optionally substituted (C1-C6)alkyl-;
R8 is selected from —H, -halogen, and optionally substituted —(C1-C6)alkyl;
R9 and each R10 are independently selected from —H, -halogen, —CN, —OH, optionally substituted —(C1-C6)alkoxy, —NH2, substituted amino, optionally substituted —(C1-C6)alkyl-NH2 and optionally substituted —(C1-C6)alkyl; and
n is 0, 1, 2, 3, 4, or 5;, with the proviso that:
a) when i) X1, X2, and X3 are C—H, or X1 and X2 are C—H and X3 is C—CH3 or N, ii) R3 is R4- C(O)—(C1-C3)alkyl-, and iii) R4 is R5R6N—:
R5 and R6 are independently selected from H—, H2N—, HO—, optionally substituted (C1-C10)alkyl-, optionally substituted monocyclic or bicyclic carbocycle, optionally substituted monocyclic or bicyclic heterocycle, optionally substituted R4C(O)—(C1-C10)alkyl-, R4C(O)—, R4-, and substituted amino; or
R5 and R6 together with the nitrogen atom to which they are attached are cyclically linked to form an unsubstituted heterocycle;

b) when i) X1 is C—F and X2 and X3 are C—H, ii) R3 is R4-C(O)-(C1-C3)alkyl- or R4-C(O)—, and R4 is R5R6N—:
R5 and R6 are independently selected from H—, H2N—, HO—, optionally substituted (C1-C10)alkyl-, optionally substituted monocyclic or bicyclic carbocycle, optionally substituted monocyclic or bicyclic heterocycle, optionally substituted R4C(O)-(C1-C10)alkyl-, R4C(O)—, R4-,and substituted amino; or
R5 and R6 together with the nitrogen atom to which they are attached are cyclically linked to form an unsubstituted heterocycle; and

c) when i) X1 and X3 are C—H and X2 is N and, ii) R3 is R4-C(O)-(C1-C3)alkyl-, R4-C(O)—, or R5R6N—, wherein iii) R4 is R5R6N—:
R5 and R6 are independently selected from H—, H2N—, HO—, optionally substituted (C1-C10)alkyl-, optionally substituted monocyclic or bicyclic carbocycle, optionally substituted monocyclic or bicyclic heterocycle, optionally substituted R4C(O)-(C1-C10)alkyl-, R4C(O)—, R4-, and substituted amino; or
R5 and R6 together with the nitrogen atom to which they are attached are cyclically linked to form an unsubstituted heterocycle;
wherein:
when one of R5 and R6 is H—:
the other one of R5 and R6 is independently selected from H2N—, HO—, unsubstituted (C1-C10)alkyl-, optionally substituted monocyclic or bicyclic carbocycle, optionally substituted monocyclic heterocycle, optionally substituted R4C(O)-(C1-C10)alkyl-, R4C(O)—, R4-, and substituted amino.