Patent ID: 11965162
Assignee: THE JOHNS HOPKINS UNIVERSITY
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A method of treating pancreatic ductal adenocarcinoma (PDA) in a subject comprising:
diagnosing the subject as being at a pre-malignant stage or early stages of developing PDA, comprising detecting one or more microRNAs (miRNAs) as having a dysregulated expression as compared to a normal control, the miRNAs selected from one or more of miR-21, miR-16 or miR-28;
administering to the subject a composition comprising a therapeutically effective amount of a microRNA-21 (miR-21) inhibitor, wherein the miR-21 inhibitor is an antagomir or antisense oligonucleotide; thereby treating pancreatic ductal adenocarcinoma.