Patent ID: 11897866
Assignee: PADLOCK THERAPEUTICS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A compound of formula I′:, or a pharmaceutically acceptable salt thereof, wherein:
Ring A is, wherein Ring A is optionally substituted with 1-4 groups selected from fluorine, —CN, —OR, or C1-6 aliphatic optionally substituted with 1-3 fluorine atoms;
Ring B is a 5 membered heteroaryl ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur;
R1 is hydrogen, —Cy, or C1-6 aliphatic optionally substituted with —Cy and optionally further substituted with 1-4 groups selected from fluorine, —CN, or —OR;
each —Cy is independently a 6-membered aryl ring containing 0-2 nitrogen atoms, or a 4-7 membered saturated monocyclic ring having 0-2 heteroatoms independently selected from nitrogen, oxygen, or sulphur, wherein —Cy is optionally substituted with 1-4 groups selected from fluorine, —CN, or —OR;
R2 is hydrogen, —CN, —OR, —Cy, or C1-10 aliphatic optionally substituted with —Cy and optionally further substituted with 1-5 groups selected from fluorine, —CN, or —OR; or:
two R2 groups on the same carbon are optionally taken together to form ═O;

n is 1, 2, or 3;
X1 is N or C(R3);
R3 is —R, halogen, or —OR;
each R is independently hydrogen or C1-6 aliphatic optionally substituted with 1-3 fluorine atoms;
L is selected from a covalent bond or a C1-6 membered straight or branched, saturated or unsaturated hydrocarbon chain wherein one methylene unit of L is optionally replaced by —S(O)2— or —C(O)N(Ry)—, wherein Ry is R or —CH2phenyl; and
R4 is halogen, R, phenyl, or a 5-6-membered heteroaryl ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, or sulphur, wherein R4 is optionally substituted with 1-4 groups independently selected from halogen, —CN, —OR, —C(O)OH, or C1-6 aliphatic optionally substituted with 1-3 fluorine atoms;
provided the following compounds are excluded:,