Patent ID: 11952427
Assignee: BRISTOL-MYERS SQUIBB COMPANY
Field: Biotechnology (Chemistry)
Classification: CPC C  A | IPC C

Claim 2:
3. A nucleic acid molecule, encoding a heavy chain variable region (VH) and a light chain variable region (VL) of an antibody, or antigen binding portion thereof, that specifically binds to human CD40, wherein the VH comprises a CDR1, CDR2, and CDR3 and the VL comprises a CDR1, CDR2, and CDR3, and wherein:
(a) the CDR1 of the VH comprises the amino acid sequence GYNMN (SEQ ID NO: 55), the CDR2 of the VH comprises the amino acid sequence NIDPYYGNTNYNQKFKG (SEQ ID NO: 56), and the CDR3 of the VH comprises the amino acid sequence LGLQLYALDY (SEQ ID NO: 58); and
(b) the CDR1 of the VL comprises the amino acid sequence RASQSLVHSNANTYLH (SEQ ID NO: 63), the CDR2 of the VL comprises the amino acid sequence KLTNRFF (SEQ ID NO: 64), and the CDR3 of the VL comprises the amino acid sequence QQSIHVPWT (SEQ ID NO: 66).