Patent ID: 11858994
Assignee: REPERTOIRE GENESIS INCORPORATION
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  G  A | IPC A  C  G

Claim 5:
6. The method of claim 5, wherein if the sample TCR diversity index that is a DE50 index (i) is normalized with respect to any one number of reads set forth as normalized number of reads in the following Table 45, and (ii) is equal to or greater than a threshold value corresponding to the normalized number of reads set forth in the Table 45:, TABLE 45

Normalized number of reads

100
300
1000
3000
10000
30000
80000

% DE50
17.14
11.04
5.80
2.58
0.96
0.39
0.18

then the subject is determined to be likely to respond to the immunotherapy with the immune checkpoint inhibitor.