Patent ID: 11971405
Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
Field: Measurement (Instruments)
Classification: CPC G  B | IPC B  G

Claim 12:
13. A method of sensing comprising:
providing a test sample comprising complexed and/or non-complexed biomolecules;
contacting the test sample with the first layer of the sensor of claim 1;
irradiating the dual nanohole structure of the first layer of the sensor with a beam of electromagnetic radiation;
optically trapping the biomolecules in the dual nanohole structure and/or the gap of the first layer of the sensor and measuring a surface plasmon resonance of the dual nanohole structure;
applying an electric field across the nanopore of the second layer of the sensor; and
measuring change in current across the nanopore during one or more translocation events of the biomolecules.