Patent ID: 11945858
Assignee: NATIONAL RESEARCH COUNCIL OF CANADA
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 12:
13. A VHH camelid single domain antibody that binds specifically to loop 3 of a domain I (DI) of a Nav 1.7 polypeptide, and which inhibits the flux of Na+ through an hNAv 1.7 channel,
wherein said VHH antibody comprises three variable domain complementarity determining regions (CDR)(CDR 1, 2 and 3), comprising the amino acid sequences:
CDR 1: GFAFSSAP (SEQ ID NO:39),
CDR 2: IESDQDHTI (SEQ ID NO:40), and
CDR 3: QKRGEKKT (SEQ ID NO:41), respectively.