Patent ID: 11878975
Assignee: BRISTOL-MYERS SQUIBB COMPANY
Field: Organic fine chemistry (Chemistry)
Classification: CPC C | IPC C

Claim 11:
12. A compound according to claim 11 or a salt thereof, wherein said compound is:
2-(3-isopropyl-2-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl) morpholine (281);
2-(3-isopropyl-2-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl) morpholine (282-283);
2-(3-isopropyl-2-(8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl) morpholine (284-285);
2-(2-(7,8-dimethyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-3-isopropyl-1H-indol-5-yl) morpholine (286-288);
2-(3-isopropyl-2-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl)-4-(oxetan-3-yl)morpholine (289);
2-(3-isopropyl-2-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl)-4-(oxetan-3-yl)morpholine (290);
2-(3-isopropyl-2-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl)-4-((3-methyloxetan-3-yl)methyl)morpholine (291-292);
2-(3-isopropyl-2-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl)-4-methylmorpholine (293, 296-297);
4-isopropyl-2-(3-isopropyl-2-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl)morpholine (294-295, 298);
2-(3-isopropyl-2-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl)-4-methylmorpholine (297);
2-(3-isopropyl-2-(8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl)-4-methylmorpholine (299, 301);
4-isopropyl-2-(3-isopropyl-2-(8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl)morpholine (300, 302);
2-(2-(2,6-dimethylpyridin-4-yl)-3-isopropyl-1H-indol-5-yl)-4-isopropylmorpholine (303, 305);
2-(2-(2,6-dimethylpyridin-4-yl)-3-isopropyl-1H-indol-5-yl)-4-(oxetan-3-yl) morpholine (304);
2-(2-(3-isopropyl-2-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl) morpholino)-N,N-dimethylacetamide (306);
2-(2-(3-isopropyl-2-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl) morpholino)-N-methylacetamide (307, 317);
2-(2-(3-isopropyl-2-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl) morpholino)-N,N-dimethylacetamide (308, 316);
2-(2-(3-isopropyl-2-(8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl) morpholino)-N,N-dimethylacetamide (309, 314);
2-(2-(3-isopropyl-2-(8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl) morpholino)-N-methylacetamide (310, 315);
2-(2-(2-(7,8-dimethyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-3-isopropyl-1H-indol-5-yl) morpholino)-N-methylacetamide (311, 313);
2-(2-(2-(7,8-dimethyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-3-isopropyl-1H-indol-5-yl) morpholino)-N,N-dimethylacetamide (312, 321);
2-(2-(3-isopropyl-2-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl) morpholino)acetamide (318);
2-(2-(2-(7,8-dimethyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-3-isopropyl-1H-indol-5-yl) morpholino)acetamide (319-320);
2-(2-(2-(2,6-dimethylpyridin-4-yl)-3-isopropyl-1H-indol-5-yl)morpholino)-N,N-dimethylacetamide (322, 326);
2-(2-(2-(2,6-dimethylpyridin-4-yl)-3-isopropyl-1H-indol-5-yl)morpholino)-N-methylacetamide (323,325);
2-(2-(2-(2,6-dimethylpyridin-4-yl)-3-isopropyl-1H-indol-5-yl)morpholino)acetamide (324, 327);
2-(dimethylamino)-1-(2-(3-isopropyl-2-(8-methyl-[1,2,4]triazolo[1,5-a] pyridin-6-yl)-1H-indol-5-yl)morpholino)ethanone (328);
1-(2-(2-(7,8-dimethyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-3-isopropyl-1H-indol-5-yl) morpholino)-2-(dimethylamino)ethan-1-one (329-330);
2-(dimethylamino)-1-(2-(3-isopropyl-2-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl)morpholino)ethan-1-one (331);
2-(dimethylamino)-1-(2-(3-isopropyl-2-(8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl)morpholino)ethan-1-one (332, 334);
2-(diethylamino)-1-(2-(3-isopropyl-2-(8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl)morpholino)ethan-1-one (333);
2-(dimethylamino)-1-(2-(2-(2,6-dimethylpyridin-4-yl)-3-isopropyl-1H-indol-5-yl) morpholino)ethan-1-one (335-336);
1-(2-(3-isopropyl-2-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl) morpholino)-2-(methylamino)ethanone (337);
1-(2-(3-isopropyl-2-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl) morpholino)-2-(methylamino)ethan-1-one (338);
1-(2-(3-isopropyl-2-(8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl) morpholino)-2-(methylamino)ethan-1-one (339, 342);
1-(2-(2-(7,8-dimethyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-3-isopropyl-1H-indol-5-yl) morpholino)-2-(methylamino)ethan-1-one (340-341);
2-(3-isopropyl-2-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl)-4-(2-(methylsulfonyl)ethyl)morpholine (343);
2-(3-isopropyl-2-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl)-4-(2-(methylsulfonyl)ethyl)morpholine (344);
2-(3-isopropyl-2-(8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl)-4-(2-methoxyethyl)morpholine (345);
2-(2-(7,8-dimethyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-3-isopropyl-1H-indol-5-yl)-4-(2-(methylsulfonyl)ethyl)morpholine (346-347);
2-(3-isopropyl-2-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl)-4-(2-methoxyethyl)morpholine (348-350);
2-(2-(2,6-dimethylpyridin-4-yl)-3-isopropyl-1H-indol-5-yl)-4-(2-(methylsulfonyl) ethyl)morpholine (351, 353);
2-(2-(2,6-dimethylpyridin-4-yl)-3-isopropyl-1H-indol-5-yl)-4-(2-methoxyethyl) morpholine (352);
1-(2-(3-isopropyl-2-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl) morpholino)-2-methylpropan-2-ol (355);
1-(2-(3-isopropyl-2-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl) morpholino)-2-methylpropan-2-ol (356);
1-(2-(2-(2,6-dimethylpyridin-4-yl)-3-isopropyl-1H-indol-5-yl)morpholino)-2-methylpropan-2-ol (357-358);
2-(ethyl(methyl)amino)-1-(2-(3-isopropyl-2-(8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl)morpholino)ethanone (359);
2-(1,1-dioxidothiomorpholino)-1-(2-(3-isopropyl-2-(8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl)morpholino)ethan-1-one (360);
1-(2-(3-isopropyl-2-(8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl) morpholino)-2-((3-methyloxetan-3-yl)amino)ethan-1-one (361);
2-(3-isopropyl-2-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl)-5,5-dimethylmorpholine (367);
2-(3-isopropyl-2-(8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl)-5,5-dimethylmorpholine (368-369);
2-(2-(7,8-dimethyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-3-isopropyl-1H-indol-5-yl)-5,5-dimethylmorpholine (370-371);
2-(dimethylamino)-1-(2-(3-isopropyl-2-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl)-5,5-dimethylmorpholino)ethanone (372-373);
2-(dimethylamino)-1-(2-(3-isopropyl-2-(8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl)-5,5-dimethylmorpholino)ethan-1-one (374);
2-(3-isopropyl-2-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl)-4,5,5-trimethylmorpholine (375-376);
2-(3-isopropyl-2-(8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl)-4,5,5-trimethylmorpholine (377);
2-(3-isopropyl-2-(8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl)-5,5-dimethyl-4-(oxetan-3-yl)morpholine (378);
2-(2-(3-isopropyl-2-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl)-5,5-dimethylmorpholino)-N,N-dimethylacetamide (379-380);
2-(3-isopropyl-2-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl)-5,5-dimethyl-4-(2-(methylsulfonyl)ethyl)morpholine (381, 384);
2-(3-isopropyl-2-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl)-4-(2-methoxyethyl)-5,5-dimethylmorpholine (382-383);
1-(2-(3-isopropyl-2-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl)-5,5-dimethylmorpholino)-2-methylpropan-2-ol (385);
2-(2-(2-(7,8-dimethyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-3-isopropyl-1H-indol-5-yl)-5,5-dimethylmorpholino)-N,N-dimethylacetamide (386-387); or
2-(2-(2-(7,8-dimethyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-3-isopropyl-1H-indol-5-yl)-5,5-dimethylmorpholino)-N-methylacetamide (388-389).