Patent ID: 11878970
Assignee: PETRA PHARMA CORPORATION
Field: Organic fine chemistry (Chemistry)
Classification: CPC C  A | IPC C

Claim 60:
61. The compound of claim 1, or pharmaceutically acceptable salt thereof, wherein R is —H or C1-C3alkyl;
R1is a group of the formula:, R2 is an optionally substituted bicyclic ring selected from 1,3-benzodioxole, 2,3-dihydro-1,4-benzodioxine, isoindolin-1-one, or benzo[d]oxazol-2(3H)-one, or an optionally substituted bicyclic heteroaryl wherein a phenyl, pyridine, pyrazine, pyrimidine, or pyridazine ring is fused to a pyrrole, furan, thiophene, pyrazole, isoxazole, imidazole, oxazole, thiazole, triazole, pyridine, pyrazine, pyrimidine, or pyridazine ring; wherein the optionally substituted bicyclic ring is optionally substituted with one to three substituents each independently selected from C1-C6 alkyl; the optionally substituted bicyclic heteroaryl is optionally substituted with one to three substituents each independently selected from 13 CN, halogen, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, 13 S021110, 13 CONRioRio, 13 NRioRio, 13 NRI0CO2R10, an optionally substituted C1-C6 alkyl, an optionally substituted C3-05 cycloalkyl, an optionally substituted heterocycle selected from pyrrolidine, pyrrolidinone, piperidine or morpholine, an optionally substituted phenyl, or an optionally substituted heteroaryl selected from pyrazole, isoxazole, isothiazole, imidazole, oxazole, or thiazole; wherein the optionally substituted C1-C6 alkyl is optionally substituted with a 13 CN, 13 OH, or C1-C3alkoxy; the optionally substituted C3-05 cycloalkyl, phenyl, heterocycle or heteroaryl is each optionally substituted with one to three substituents each independently selected from halogen, C1-C3 alkyl, C1-C3haloalkyl, C1-C3 alkoxy, C1-C3 haloalkoxy, 13 NRioRio, 13 OH or 13 CN;
R3 is 13 H, 13 CN, C1-C6 alkyl or C1-C6 haloalkyl;
each of R4, R5 and R6 is independently 13 H, halogen, C1-C6 alkyl or C1-C6 haloalkyl;
R7 is 13 CN, C1-C6 alkyl or C1-C6 haloalkyl;
R8 is 13 H or C1-C6 alkyl;
each R9 is independently 13 H, halogen, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, or C3-C5 cycloalkyl; and
each R10 is independently 13 H or C1-C3 alkyl.