Patent ID: 11905511
Assignee: FRED HUTCHINSON CANCER CENTER
Field: Biotechnology (Chemistry)
Classification: CPC C  G | IPC C  G

Claim 0:
1. A method of providing diagnostic assessment of immunocompetence in a solid organ transplant recipient undergoing immune suppressive therapy, comprising:
(a) identifying a T cell repertoire in the recipient in vitro;
(b) determining the diversity of said T cell repertoire identified in step
(a) in a pre-transplant sample from the recipient;

(c) determining the diversity of said T cell repertoire identified in step
(a) in a post-transplant sample from the recipient;

(d) comparing the diversities of said T cell repertoire in said pre- and post-transplant samples;
(e) determining that immune reconstitution is not occurring based on the comparison of the diversities of said T cell repertoire in the post-transplant sample and the pre-transplant sample; and
(f) actively modifying treatment to withdraw immunosuppressive therapy to the recipient.