Patent ID: 11965039
Assignee: ZP SPV 3 K/S
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 6:
7. A compstatin analogue according to claim 1, represented by the formula:

Y1-R1-X1-C-I-X4-Q-X6-W-G-E-H-R-C-X13-R2-Y2  (Formula V) (SEQ ID NO: 331)

wherein:
Y1 is hydrogen or acetyl;
X1 is Y or F;
X4 is W, Y, 1-Me-Trp;
X6 is E or D;
X13 is T, E or Sar;
Y2 is NH2 or OH;
R1 is absent or is a sequence of 1 to 6 amino acid residues selected from A, E, G, L, K, F, P, S, T, W, Y, R, V, Sar, εLys, γGlu, βAsp, or βAla, or a corresponding D form thereof, or Peg3, Peg4, or 8-aminooctanoyl, or derivatives thereof; and
R2 is absent or is a sequence of 1 to 6 amino acid residues selected from A, E, G, L, K, F, P, S, T, W, Y, R, V, Sar, εLys, γGlu, βAsp, or βAla, or a corresponding D form thereof; or Peg3 or Peg4, or 8-aminooctanoyl, or derivatives thereof;
wherein the compstatin analogue has a disulphide bond between the cysteine residues at positions 2 and 12 relative to a 13-mer portion of the compstatin analogue from the X1 residue to the X13 residue;
or a pharmaceutically acceptable salt thereof.