Patent ID: 11938324
Assignee: THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
Field: Medical technology (Instruments)
Classification: CPC A | IPC A

Claim 1:
2. A vagus nerve stimulation system, comprising:
at least one interface configured to provide communication with at least one of a heart rate measuring device, a breathing rate measuring device, a electromyography measuring device, a signal generator, at least two vagus nerve electrodes, a display, a user input device, and;
a controller communicably coupled with the at least one interface, the controller configured to:
control the signal generator to generate and apply electrical signals based on a first set of parameters to the at least two vagus nerve electrodes,
receive physiological measurements from the heart rate measurement device, the breathing rate measurement device, and the electromyography measurement device, the physiological measurements including heart rate measurements, breathing interval measurements, and electromyography measurements,
receive from the user input device an indication selecting for activation one of afferent A-type fibers, efferent A-type fibers, and B-type fibers,
determine based on the received physiological measurements, a set of physiological selectivity indices (PSIs), a set of neural selectivity indices (NSIs), and a set of fiber activation magnitudes associated with a selected one of the afferent A-type fibers, the efferent A-type fibers, and the B-type fibers,
vary at least one parameter of the first set of signal parameters while controlling the signal generator to generate and apply a second set of electrical signals based on the varied set of signal parameters to the at least two vagus nerve electrodes and monitoring resulting changes in at least one of the set of PSIs, the set of NSIs, and the set of fiber activation magnitudes,
determine a preferred set of signal parameters for stimulus waveforms for activating the selected one of the afferent A-type fibers, the efferent A-type fibers, and the B-type fibers, the preferred set of signal parameters resulting in predetermined changes in the set of PSIs and the set of NSIs, and
control the signal generator to generate and apply to the at least two vagus nerve electrodes electrical signals based on the preferred set of signal parameters.