Patent ID: 11931349
Assignee: DEUTSCHES KREBSFORSCHUNGSZENTRUM STIFTUNG DES öFFENTLICHEN RECHTS
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 6:
7. A method for inducing an irreversible proliferation arrest in hypoxic cancer cells comprising:
(a) contacting the hypoxic cancer cells with an iron chelator or prodrug thereof and, thereby,
(b) inducing an irreversible proliferation arrest in the hypoxic cancer cells,
wherein the iron chelator or prodrug thereof comprises a structure (I), wherein:
n is 0, 1, 2, 3, 4, 5, or 6;
R1 is H, optionally substituted carbonyl, optionally substituted phosphoryl, or optionally substituted sulfonyl;
R2 is selected from cyclohexyl, —H, C1-C6 alkyl, C5-C8 cycloalkyl, C1-C6 alkoxy, and halogen;
R4 is selected from methyl, —H, C1-C6 alkyl, C5-C8 cycloalkyl, C1-C6 alkoxy, and halogen; and
R3 and R5 are independently selected from —H, C1-C6 alkyl, C5-C8 cycloalkyl, C1-C6 alkoxy, and halogen.