Patent ID: 11926628
Assignee: GILEAD SCIENCES, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 1:
2. A compound of Formula (I):, or a pharmaceutically acceptable salt thereof, wherein
Z1 is N or CR1; R1 is hydrogen;
Z2 is N or CR2; R2 is hydrogen, C1-6 alkyl, halogen, C1-6 haloalkyl, —OR2a, —N(R2a)(R2b);
R2a and R2b are each independently hydrogen or C1-6 alkyl which can be the same or different;
Z4 is N or CR4; R4 is hydrogen, C1-6 alkyl, or halogen;
Z7 is N or CR7; R7 is hydrogen or C1-6 alkyl;
Z8 is N or CR8; R8 is hydrogen or C1-6 alkyl;
Z9 is N or CR9; R9 is hydrogen or C1-6 alkyl;
R3 is hydrogen, C1-6 alkyl, or halogen;
R5 is C1-6 alkyl or C1-6 haloalkyl;
R6 is phenyl or heteroaryl, wherein the phenyl or heteroaryl is optionally substituted with 1 to 3 R6a which can be the same or different, wherein the heteroaryl is a 5 or 6 membered ring having 1 to 3 heteroatoms each independently N, O or S;
or, is, X1, X2, X3, and X4 are each independently CH, N, or C—R6a, provided that not more than two of X1, X2, X3, and X4 are N, and not more than two of X1, X2, X3, and X4 are C—R6a;
Ring A is a 5 to 8 membered heterocycloalkyl optionally having 1 to 2 additional heteroatoms each independently N, O, or S, and optionally Ring A is substituted with 1 or 2 R6g which can be the same or different;
each R6a is independently halogen, C2-8 alkynyl, phenyl, heterocycloalkyl, or heteroaryl, wherein the phenyl, heterocycloalkyl, or heteroaryl is each optionally substituted with 1 to 3 R6e, and the alkynyl is optionally substituted with 1 to 4 R6j which can be the same or different, wherein the heterocycloalkyl is a 3 to 10 membered ring having 1 to 3 heteroatoms each independently N, O or S, the heteroaryl is a 5 or 6 membered ring having 1 to 3 heteroatoms each independently N, O or S;
each R6j is independently halogen, C1-6 haloalkyl, —OR6j1, —CN, C3-10 cycloalkyl, heterocycloalkyl, or heteroaryl, wherein the cycloalkyl, heterocycloalkyl, or heteroaryl is optionally substituted with 1 to 3 R6p which can be the same or different, the heterocycloalkyl is a 3 to 10 membered ring having 1 to 3 heteroatoms each independently N, O or S, the heteroaryl is a 5 or 6 membered ring having 1 to 3 heteroatoms each independently N, O or S;
each R6j1 is independently hydrogen, C1-6 alkyl, or C1-6 haloalkyl;
each R6P is independently halogen, C1-6 alkyl or C1-s haloalkyl;
each R6e is independently C1-6 alkyl, C3-6 cycloalkyl, heterocycloalkyl, halogen, C1-6 haloalkyl, —CN, —OR6e1, or —SF5, wherein the cycloalkyl and heterocycloalkyl are optionally substituted with 1 to 3 R6h which can be the same or different, the heterocycloalkyl is a 3 to 10 membered ring having 1 to 3 heteroatoms each independently N, O or S;
R6e1 is hydrogen or C1-6 alkyl;
each R6h is independently C1-6 alkyl, C1-6 haloalkyl, ═O, or —OH; and
each R6g is independently C1-6 alkyl, halogen, or C1-6 haloalkyl;
provided that at least one of Z7, Z8 and Z9 is N, and when Z7 is CR7 and both Z8 and Z9 are N, at least one of Z1, Z2, and Z4 is N.