Patent ID: 11878014
Assignee: WEST VIRGINIA UNIVERSITY
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 5:
6. A pharmaceutically acceptable composition comprising:
an effective amount of ketamine or dextromethorphan, or both ketamine and dextromethorphan, wherein said ketamine or said dextromethorphan, or both are distributed within a pharmaceutically acceptable vehicle, wherein said vehicle is capable of being placed in contact with a mucosal membrane of a patient, and wherein said pharmaceutically acceptable vehicle is a device having a mucoadhesive layer containing said ketamine buffered to a pH of between about 4.0 and 7.0, and a non-adhesive backing layer buffered to a pH of between 4.0 and 6.0 wherein the pH of said mucoadhesive layer and said pH of said non-adhesive backing layer are different, wherein said mucoadhesive layer and said non-adhesive backing layer comprise different combinations of polymers but each of said mucoadhesive layer and said non-adhesive backing layer comprise at least one water-erodible polymer wherein said water-erodible polymer is at least one selected from the group consisting of a sodium carboxymethylcellulose, a hydroxyethyl cellulose, a hydroxyethylmethyl cellulose, a hydroxyethyl cellulose, a hydroxypropyl cellulose, a polyvinyl alcohol, a polyethylene glycol, a polyethylene oxide, and an ethylene oxide-propylene oxide co-polymer.