Patent ID: 11910788
Assignee: REGENERON PHARMACEUTICALS, INC.
Field: Measurement (Instruments)
Classification: CPC A  C  G | IPC A  C  G

Claim 10:
11. The isolated tissue of claim 10, wherein the genome of the cells in the tissue and the genome of the mouse further comprise a replacement of a genomic fragment comprising exons 2, 3 and 4 of a mouse SIRPα gene at an endogenous mouse SIRPα locus with a genomic fragment comprising exons 2, 3 and 4 of a human SIRPα gene to form a humanized SIRPα gene, wherein the humanized SIRPα gene is operably linked to the endogenous mouse SIRPα promoter at the endogenous mouse SIRPα locus, and wherein the humanized SIRPα gene encodes a humanized SIRPα protein comprising an extracellular portion of the human SIRPα protein encoded by the human SIRPα gene and an intracellular portion of the mouse SIRPα protein encoded by the mouse SIRPα gene.