Patent ID: 11963968
Assignee: MASSACHUSETTS EYE & EAR INFIRMARY
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 4:
5. A composition comprising an effective amount of least one mechanistic target of rapamycin (mTOR) activator, wherein the mTOR activator comprises mhy1485, 3-benzyl-5-((2-nitrophenoxy) methyl)-dihydrofuran-2(3H)-one (3BDO), salidroside, or polynucleotides encoding mTOR; and one or more phosphatase and tensin homolog (PTEN) inhibitors or one or more Atonal Homolog 1 (Atoh1) activators, wherein the Atoh1 activators comprise β-catenin or Atoh1 polynucleotides.