Patent ID: 11883246
Assignee: TRUSTEES OF BOSTON UNIVERSITY
Field: Medical technology (Instruments)
Classification: CPC A | IPC A

Claim 0:
1. A method comprising:
implanting into a target tissue at a target site, a tissue marker comprising a flexible polymer matrix, wherein the flexible polymer matrix comprises a sheet, wherein the sheet when in a substantially planar configuration, comprises at least two films with a first contrast agent located between the surfaces of the at least two films, the first contrast agent detectable by at least one imaging modality, such that the tissue marker is visible by one or more imaging modalities,
wherein the flexible polymer matrix is implanted into the tissue in a rolled configuration as a hollow cylinder, and the flexible polymer matrix has a density that differs by no more than 30% from the target tissue, which is a soft tissue selected from the group consisting of breast tissue, colon tissue, rectal tissue, liver tissue, ovarian tissue, prostate tissue, and lung tissue, and wherein upon the implantation at the target site, the flexible polymer matrix at least partially unrolls to form a planar shape or partially unrolled cylinder while maintaining the density of the flexible polymer matrix for a period of at least 60 seconds,
wherein the tissue marker is implanted without the use of an adhesive and wherein the density and the partially unrolled configuration of the flexible polymer matrix prevents the tissue marker from migrating more than 10 mm from the target site over a period of at least one month.