Patent ID: 11944848
Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
Field: nan (nan)
Classification: CPC nan | IPC A

Claim 0:
1. An ultrasound pressure-based method comprising:
delivering a gas vesicle (GV) to a target site, the GV having a GV type collapse threshold pressure; setting an ultrasound generation system to produce ultrasound pulses having a positive pressure set above the GV type collapse threshold pressure, a negative pressure and at least one of: a duty cycle above 0.2% or a mechanical index above 2.8; and applying the ultrasound pulses to the target site, thus: collapsing the GV by the positive pressure of the ultrasound pulses, thereby forming gas bubbles; and
driving a cavitation of the gas bubbles by the negative pressure wherein the gas vesicle comprises a variant GvpC engineered to comprise binding tags presented on the GV and configured to bind to a target molecule on a cavitation target.