Patent ID: 11872268
Assignee: THERIVA BIOLOGICS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C  Y | IPC A

Claim 0:
1. A method of protecting a human patient's gastrointestinal microbiome, comprising administering an effective amount of a pharmaceutical composition comprising a beta-lactamase to a patient in need thereof, wherein:
the patient is undergoing treatment or has recently undergone treatment with a beta-lactam antibiotic, wherein the beta-lactam antibiotic is a penicillin or a cephalosporin;
the patient is undergoing treatment with a proton pump inhibitor, wherein the proton pump inhibitor is esomeprazole, omeprazole, lansoprazole, rabeprazole, pantoprazole, or dexlansoprazole; and
the beta-lactamase comprises an amino acid sequence having at least 98% identity with SEQ ID NO: 1.