Patent ID: 11884933
Assignee: IMBA—INSTITUT FÜR MOLEKULARE BIOTECHNOLOGIE GMBH
Field: Measurement (Instruments)
Classification: CPC C  G | IPC C  G

Claim 19:
20. The elongated multicellular aggregation of claim 19 obtainable by the method of generating multicellular aggregation of neural lineage with neuronal differentiated cells comprising the steps of:
a) providing a plurality of pluripotent or non-human totipotent cells (i) that are located in an oblong or longish arrangement adhered to a support, said support has a length of 20 μm to 20 mm and a diameter of 1 μm to 60 μm, wherein said support is a biocompatible polymer that is not a biopolymer or wherein said support is a protein, or (ii) that are arranged on a fibrous structured support, and said support has a length of 20 μm to 20 mm and a diameter of 1 μm to 60 μm, wherein said fibrous structured support is a biocompatible polymer that is not a biopolymer or wherein said fibrous structured support is a protein; and
b) letting said cells grow and differentiate in said arrangement, wherein said cells form intercellular bonds and adhere to each other;
wherein said cells are stimulated to differentiate by a contacting the cells with a neuronal growth or differentiation factor; and
wherein in said method said support is dissolved or bio-resorbed after step b).