Patent ID: 11872278
Assignee: MODERNATX, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C  Y | IPC A  C

Claim 9:
10. A messenger ribonucleic acid (mRNA) vaccine, comprising:
(a) an mRNA comprising an open reading frame encoding a human metapneumovirus (hMPV) F protein;
(b) an mRNA comprising an open reading frame encoding a respiratory syncytial virus (RSV) F protein; and
(c) a lipid nanoparticle comprising 20-60 mol % ionizable cationic lipid, 5-25 mol % distearoylphosphatidylcholine (DSPC), 25-55 mol % cholesterol, and 0.5-15 mol % polyethylene glycol (PEG)-modified lipid,
wherein 100% of the uracil in the open reading frame of the mRNA of (a) comprises a 1-methylpseudouridine, and 100% of the uracil in the open reading frame of the mRNA of (b) comprises a 1-methylpseudouridine.