Patent ID: 11913898
Assignee: ASCENSIA DIABETES CARE HOLDINGS AG
Field: Measurement (Instruments)
Classification: CPC G | IPC G

Claim 19:
20. A biosensor system for determining an analyte concentration in a biological fluid sample, the biosensor system being an optical system or an electrochemical system, the biosensor system comprising:
a test sensor having a base and a sample interface, the base forming a reservoir and a channel with an opening, the opening being configured to receive a biological fluid sample and to allow the biological fluid sample to flow through the channel to fill at least in part the reservoir; and
a measurement device in electrical or optical communication with the reservoir, the measurement device having electrical circuitry communicatively coupled to a processor, a storage medium, a signal generator, and a sensor interface, the processor having instructions and data stored in the storage medium, the instructions configured such that when executed by the processor cause the system to:
measure, one or more analyte responsive output signals from a reference sample, wherein the one or more analyte responsive output signals are indicative of an effect of one or more extraneous stimuli on the reference sample,
determine a normalizing relationship based on linear or non-linear regression of the one or more analyte responsive output signals;
store the normalizing relationship in the storage medium, wherein the normalizing relationship is stored as part of calibration information used for calibrating the biosensor system to account for the one or more extraneous stimuli;
responsive to receiving a biological fluid sample, apply an electrical or optical input signal to generate an input signal from the signal generator;
generate at least one analyte responsive output signal, wherein the one or more analyte responsive output signals is an electrical output signal generated by a redox reaction or a light-generated output signal in response to a light-identifiable species;
determine an initial analyte concentration of the biological fluid sample based on the at least one analyte responsive output signal;
determine, using the normalizing relationship, at least one normalized output signal from the at least one analyte responsive output signal;
determine a pseudo-reference concentration value of the biological fluid sample,
wherein the pseudo-reference concentration value is a substitute for true relative error;
determine at least one corresponding normalized output signal by selecting at least one reference sample analyte concentration from a plurality of stored reference sample analyte concentration and a normalized reference correlation;
determine a system error for the at least one analyte responsive output signal through a comparison of the initial analyte concentration and the at least one reference sample analyte concentration,
wherein the system error contributes to inaccurate analyte concentration determinations;
responsive to determining the system error, determine at least one signal-based anchor parameter based on a comparison of the pseudo-reference concentration value and the at least one corresponding normalized output signal, wherein the at least one signal-based anchor parameter compensates for the system error;
incorporate the at least one signal-based anchor parameter into a compensation relationship, wherein the compensation relationship compensates for inaccuracies caused by the system error;
determine a final compensated analyte concentration of the biological fluid sample based at least in part on the compensation relationship and the initial analyte concentration of the biological fluid sample; and
output the final compensated analyte concentration to one or more of a display, a remote receiver, or a storage medium.