Patent ID: 11945839
Assignee: HOFFMANN-LA ROCHE, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC C

Claim 9:
10. The method according to claim 7, wherein the antibody comprises
a) two light chains and two heavy chains of an antibody, which specifically binds to a first antigen and comprises two Fab regions;
b) two additional Fab regions of an antibody which specifically binds to a second antigen, wherein said additional Fab regions are fused both via a peptide connector either at the C- or N-termini of the heavy chains of a); wherein in the Fab regions the following modifications are performed:
i) in both Fab regions of a), or in both Fab regions of b), the variable domains VL and VH are replaced by each other, and/or the constant domains CL and CH1 are replaced by each other,
ii) in both Fab regions of a) the variable domains VL and VH are replaced by each other, and the constant domains CL and CH1 are replaced by each other, and in both Fab regions of b) the variable domains VL and VH are replaced by each other, or the constant domains CL and CH1 are replaced by each other,
iii) in both Fab regions of a) the variable domains VL and VH are replaced by each other, or the constant domains CL and CH1 are replaced by each other, and in both Fab regions of b) the variable domains VL and VH are replaced by each other, and the constant domains CL and CH1 are replaced by each other,
iv) in both Fab regions of a) the variable domains VL and VH are replaced by each other, and in both Fab regions of b) the constant domains CL and CH1 are replaced by each other, or
v) in both Fab regions of a) the constant domains CL and CH1 are replaced by each other, and in both Fab regions of b) the variable domains VL and VH are replaced by each other.