Patent ID: 11910787
Assignee: REGENERON PHARMACEUTICALS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 0:
1. A rodent ES cell, comprising a replacement of a nucleotide sequence of an endogenous rodent Tmprss4 gene at an endogenous rodent Tmprss4 locus with a nucleotide sequence of a human TMPRSS4 gene to form a humanized Tmprss4 gene,
wherein the humanized Tmprss4 gene is under control of the promoter of the endogenous rodent Tmprss4 gene at the endogenous rodent Tmprss4 locus, and
wherein the humanized Tmprss4 gene encodes a humanized Tmprss4 protein that comprises (i) an ectodomain of the human TMPRSS4 protein encoded by the human TMPRSS4 gene, and (ii) a cytoplasmic and transmembrane portion encoded by the endogenous rodent Tmprss4 gene.