Patent ID: 11969507
Assignee: EVONIK OPERATIONS GMBH
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  B | IPC A  B

Claim 13:
14. The process as claimed in claim 13,
wherein the apparatus further comprises a third reservoir vessel for accommodating a third liquid phase and a third feed by which the third reservoir vessel is in fluid communication with the active element,
wherein the active element is adapted for providing an at least triphasic mixture by mixing the first liquid phase with the second liquid phase and the third liquid phase, and wherein the first feed inside the vertical section is formed from a first linear pipeline, the second feed inside the vertical section is formed from a second linear pipeline, and the third feed inside the vertical section is formed from a third linear pipeline,
wherein
the third feed is vertically oriented at least on the vertical section;
on the vertical section the third feed is arranged inside the first feed; and
the third feed is axially displaceable on the vertical section such that an axial position of the third feed relative to the first feed is adjustable;
the process comprising:
a) providing the first liquid phase in the first reservoir vessel, wherein the first liquid phase contains the first liquid dispersion medium and wherein the pH of the first liquid phase is between 6 and 8;
b) providing the second liquid phase in the second reservoir vessel, wherein the second liquid phase contains the second liquid dispersion medium and at least one precursor to a nanocarrier and/or to an active ingredient, and wherein a pH of the second liquid phase is between 3 and 5;
c) providing the third liquid phase in the third reservoir vessel, wherein the third liquid phase comprises a third liquid dispersion medium and at least one further component, wherein the further component is selected from the group consisting of a precursor to a nanocarrier, an active ingredient, and a precursor to an active ingredient;
d) propelling the pump to establish a liquid flow from the first reservoir vessel via the first feed into the active element and via the discharge into the collection vessel; and
e) mixing the first liquid phase and the second liquid phase and the third liquid phase by metering the third liquid phase via the third feed into the active element, wherein a volume flow of the third liquid phase in the third feed is smaller than the volume flow of the liquid flow in the first feed.