Patent ID: 11857638
Assignee: PROMEGA CORPORATION
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C  G | IPC A  C  G

Claim 0:
1. A conjugate of formula (I), or a salt thereof,

Cb-(G)p   (I)

wherein
Cb is a cell binding moiety;
p is a number from 1 to 20;
G is formula (II), (III), or (IV), R9 and R10 are each independently selected from C1-4alkyl;
R11, R12, and R13 are each independently selected from the group consisting of H, C1-4alkyl, C1-4alkoxy, bromo, chloro, and amino, or R11 and R12 in formula (II) or (IV), together with the atoms to which they are attached form a fused phenyl ring;
L1 is a first linker moiety;
L2 is a second linker moiety;
G1 is -A2,, G2 is, X1 and X2 are each an antibody-linking moiety;
Y is O or NR15;
R14 and R5 are each independently H, C1-30alkyl optionally substituted with 1-8 halogens, —C1-30alkylene-OH, —C1-30alkylene-C1-4alkoxy, —C1-30alkylene-COOH, or —C1-30alkylene-amido;
R16, at each occurrence, is independently H, halogen, CH3, OCH3, or NO2;
R17, at each occurrence, is independently H or C1-4alkyl or both R17 together with the carbon to which they are attached form a cycloalkyl ring having from 3-7 carbons;
m is an integer from 0-2;
n is an integer from 0-2;
A1 is a payload moiety bonded through a substitutable oxygen or sulfur atom; and
A2 is a payload moiety bonded through a substitutable oxygen, sulfur, or nitrogen atom.