Patent ID: 11905523
Assignee: GINKGO BIOWORKS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. An adeno-associated virus (AAV) vector comprising:
(i) a protein capsid comprising a capsid protein subunit comprising the sequence of SEQ ID NO: 180; and
(ii) a nucleic acid encapsidated by the protein capsid;
wherein the nucleic acid comprises a transfer cassette;
wherein the transfer cassette comprises, from 5′ to 3′:
a 5′ inverted terminal repeat (ITR);
a promoter;
a transgene that encodes a Niemann-Pick intracellular cholesterol transporter 1 (NPC1) protein;
a polyadenylation signal; and
a 3′ ITR.