Patent ID: 11858968
Assignee: NEW YORK UNIVERSITY
Field: Biotechnology (Chemistry)
Classification: CPC C | IPC C

Claim 0:
1. A modified yeast comprising: i) a mutated yeast DAD1 gene, the mutated yeast DAD1 gene encoding an E50D mutation in yeast DAD1 protein, and/or ii) one or more modified yeast chromosomes that are modified such that yeast histone H2A is replaced by human histone H2A, wherein the human H2A comprises a deletion of at least one of R, Q and R in positions 3, 5 and 12, respectively, of human H2A histone sequence, and a replacement of human H2A amino acids that are human Q112 with H, human A113 with Q, and human V114 with N.