Patent ID: 11920184
Assignee: ROCHE SEQUENCING SOLUTIONS, INC.
Field: Measurement (Instruments)
Classification: CPC C  G | IPC C  G

Claim 0:
1. A method for concentrating a target molecule for nanopore sensing, comprising: capturing the target molecule on a surface, wherein the surface comprises a nanopore and a hydrophobic domain, wherein the target molecule comprises a target portion, a hydrophobic capture element and a leader for interaction with the nanopore, wherein the target portion is an Xpandomer, wherein the Xpandomer is a measurable polymer comprising high signal-to-noise reporters that are separated by approximately 10 nm, wherein the hydrophobic capture element is an aliphatic hydrocarbon, wherein the aliphatic hydrocarbon comprises 5 repeats of a 12 carbon monomer, and wherein the leader is a hydrophobic polymer, wherein the hydrophobic polymer comprises 25 repeats of an ethyl phosphodiester, wherein the hydrophobic capture element is associated with, and capable of movement along, the hydrophobic domain of the surface to bring the leader in proximity with the nanopore; and sensing at least the target portion upon interaction with the nanopore.