Patent ID: 11903935
Assignee: DISARM THERAPEUTICS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C  Y | IPC A

Claim 0:
1. A method of inhibiting SARM1 NADase activity, comprising contacting SARM1 with a SARM1 NADase inhibitor, wherein the SARM1 NADase inhibitor is a compound of formula IA:, , or a pharmaceutically acceptable salt thereof, wherein:
XA is —S—, —SO— or —SO2—;
R1A is hydrogen, C1-4 aliphatic, alkali metal, alkaline earth metal, ammonium or N+(C1-4alkyl)4;
Ring AA is selected from a benzo fused ring and a 5-6 membered heteroaromatic fused ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, and sulfur;
Ring BA is selected from phenyl, an 8-10 membered bicyclic aromatic carbocyclic ring, a 4-8 membered saturated or partially unsaturated monocyclic heterocyclic ring having 1-2 heteroatoms independently selected from nitrogen, oxygen, or sulfur, a 5-6 membered monocyclic heteroaromatic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or an 8-10 membered bicyclic heteroaromatic ring having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur;
RXA and RYA are independently hydrogen, C1-4 aliphatic optionally substituted with 1-4 halogen, —ORA, —SRA, —N(RA)2, —N(RA)C(O)RA, —C(O)N(RA)2, —N(RA)C(O)N(RA)2, —N(RA)C(O)ORA, —OC(O)N(RA)2, —N(R)S(O)2RA, —S(O)2N(RA)2, —C(O)RA, —C(O)ORA, —OC(O)RA, —S(O)RA, —S(O)2RA, phenyl, an 8-10 membered bicyclic aromatic carbocyclic ring, a 4-8 membered saturated or partially unsaturated monocyclic heterocyclic ring having 1-2 heteroatoms independently selected from nitrogen, oxygen, or sulfur, a 5-6 membered monocyclic heteroaromatic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or an 8-10 membered bicyclic heteroaromatic ring having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur;
each RA is independently hydrogen or an optionally substituted group selected from C1-6 aliphatic, a 3-8 membered saturated or partially unsaturated monocyclic carbocyclic ring, phenyl, an 8-10 membered bicyclic aromatic carbocyclic ring, a 4-8 membered saturated or partially unsaturated monocyclic heterocyclic ring having 1-2 heteroatoms independently selected from nitrogen, oxygen, or sulfur, a 5-6 membered monocyclic heteroaromatic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or an 8-10 membered bicyclic heteroaromatic ring having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur;
mA and nA are independently 0, 1, 2, or 3.