Patent ID: 11906519
Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
Field: Measurement (Instruments)
Classification: CPC C  G  A | IPC G

Claim 0:
1. A method of identifying a modulator of Leukocyte Immunoglobulin-Like Receptor B4 (LILRB4) activation comprising:
(a) contacting a reporter cell with Apolipoprotein E (ApoE) and a candidate substance, wherein the reporter cell expresses a reporter gene that encodes a detectable reporter operably linked to a promoter regulated by activation of LILRB4; and
(b) detecting a level of LILRB4 activation in the reporter cell, wherein an increase or decrease in the level of LILRB4 activation as compared to a reference level measured from a reporter cell not treated with said candidate substance indicates that the candidate substance is a modulator of LILRB4 activation in the reporter cell.