Patent ID: 11951173
Assignee: BLISS BIOPHARMACEUTICAL (HANGZHOU) CO., LTD.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 0:
1. An antibody-drug conjugate (ADC) or a pharmaceutically acceptable salt thereof, comprising:
a tetravalent monoclonal antibody conjugated to a cytotoxic drug by a chemical linker,
wherein the monoclonal antibody comprises:
two long chains and four short chains, wherein each of the long chains comprises a first segment and a second segment, the first segment located proximal to the N-terminus of the long chain, and the second segment located proximal to the C-terminus of the long chain, each of the first segment and second segment paring with one of the short chains to form an antigen-binding fragment domain, therefore forming four antigen-binding fragment domains having specificity toward a same antigen;

and wherein:
(a) each of the long chains comprises the sequence of SEQ ID NO:1 and each of the short chains comprises the sequence of SEQ ID NO:2; or
(b) each of the long chains comprises the sequence of SEQ ID NO:13 and each of the short chains comprises the sequence of SEQ ID NO:14; or
(c) each of the long chains comprises the sequence of SEQ ID NO:15 and each of the short chains comprises the sequence of SEQ ID NO:16; or
(d) each of the long chains comprises the sequence of SEQ ID NO:17 and each of the short chains comprises the sequence of SEQ ID NO:18; or
(e) each of the long chains comprises the sequence of SEQ ID NO:21 and each of the short chains comprises the sequence of SEQ ID NO:22; or
(f) each of the long chains comprises the sequence of SEQ ID NO:23 and each of the short chains comprises the sequence of SEQ ID NO:24.