Patent ID: 11873328
Assignee: SUN PHARMACEUTICAL INDUSTRIES LIMITED
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A polypeptide having the amino acid sequence:, (SEQ ID NO: 15)

H-X2-X3-X4-G-T-F-T-S-D-V-S-S-Y-L-X16-G-Q-A-A-X21-

E-F-X24-A-W-L-V-R-G-R-G-X33-X34

wherein X2 is Ser, Ser(OMe), Aib, Ala, Gly, Val, Leu, Ile, (1-amino C3-8 cycloalkyl) carboxylic acid, Trp or Thr;
X3 is absent or Gin;
X4 is Gin or Glu;
X16 is Glu or Asp;
X24 is Ile or Val or Leu;
X33 Leu, Ile, Tyr or absent;
X34 is Ser, Lys, Ala or absent; and
X21 is Lys wherein the side chain amino (ε amino) group of Lys is acylated with a moiety:

{-U-W-Y-Z

wherein
U is —C(O)-M-NH—; wherein the carbonyl is attached to the Lys ε amino and M is a C5-10 alk chain interrupted with 1, 2 or 3 oxygen atoms;
W is —C(O)—N(R1)—C2-5alk-N(R1)—, —C(O)—C(CH3)2—N(R2)—; or, wherein R1, R2 and R3 are independently hydrogen or C1-3 alkyl and the carbonyl in W is attached to the N in U;

Y is —C(O)—(CH2)m—CH(COOH)NH— wherein m is an integer selected from 1 to 2 and — is point of attachment with the group Z; and
Z is —C(O)—(CH2)n—COOH or —C(O)—(CH2)n—CH3 wherein n is an integer from 10 to 20.