Patent ID: 11883495
Assignee: LEPU BIOPHARMA CO., LTD.
Field: Measurement (Instruments)
Classification: CPC A  C  G | IPC A  C  G

Claim 0:
1. A method of treating cancer in a human patient having the cancer, comprising administering to the patient an effective amount of a monoclonal antibody or fragment thereof, wherein the antibody or fragment thereof has specificity to a human CD47 (Cluster of Differentiation 47) protein, and the antibody or the fragment comprises:
(a) a VH CDR1 comprising the amino acid sequence of SEQ ID NO: 1;
(b) a VH CDR2 comprising the amino acid sequence of SEQ ID NO: 7;
(c) a VH CDR3 comprising the amino acid sequence of SEQ ID NO: 8;
(d) a VL CDR1 comprising the amino acid sequence of SEQ ID NO: 9;
(e) a VL CDR2 comprising the amino acid sequence of SEQ ID NO: 5; and
(f) a VL CDR3 comprising the amino acid sequence of SEQ ID NO: 10, and wherein the fragment is selected from the group consisting of F(ab′)2, Fab′, Fab, Fv, and scFv, wherein the cancer comprises cancer cells that express the human CD47 protein in the human patient.