Patent ID: 11866743
Assignee: TELEDYNE FLIR DETECTION, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 13:
14. A method for treating or ameliorating one or more effects of exposure to a chemical warfare agent in a human, the method comprising administering to the human an effective amount of an organophosphorus hydrolase (OPH) protein:polymer conjugate that comprises an enzymatically-active, genetically-modified OPH protein, selected from the group consisting of OPH YT protein, OPH C23 protein, and OPH IVH3 protein conjugated to at least a first polymer, wherein the polymer has a molecular weight in a range of 175 kDa to 222 kDa and comprises a PEGMA chain; wherein an in vivo kcat/km of the protein:polymer conjugate is: ≥1×105 for at least one chemical warfare agent, fora time sufficient to treat or ameliorate the one or more effects of exposure to a chemical warfare agent in the human.