Patent ID: 11939633
Assignee: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
Field: Measurement (Instruments)
Classification: CPC C  G | IPC C  G

Claim 0:
1. A method for treating a blood-related disease in a subject in need thereof, the method comprising administering to the subject an effective amount of an inhibitor of expression of COTL1 protein,
wherein the blood-related disease is a leukemia caused by an increase in abnormal proliferation of hematopoietic stem cells, and the treating comprises a decrease in a number of hematopoietic stem cells compared to prior to the administering,
wherein the administering reduces a number of hematopoietic stem cells, and
wherein the inhibitor is any one selected from the group consisting of an antisense nucleotide, a small interfering RNA (siRNA), and a short hairpin RNA (shRNA), which each bind complementarily to the mRNA of the COTL1 gene, and a combination thereof,
wherein the inhibitor is a morpholino oligonucleotide comprising the sequence of SEQ ID: 5.