Patent ID: 11957123
Assignee: SPERMVITAL AS
Field: Basic materials chemistry (Chemistry)
Classification: CPC A | IPC A

Claim 22:
23. A kit for preparing a sustained release composition, the kit comprising a first container and a second container; the first container comprising an active crosslinker and either a first diffusion barrier or a second diffusion barrier; the second container comprising an ionically crosslinkable biocompatible polymer and optionally a material to be released; the first and/or second diffusion barrier allowing delayed and sustained release of the active crosslinker;
wherein
the first container and/or the second container are of a size and form which allows the ionically crosslinkable biocompatible polymer to come into contact with the active crosslinker throughout the first container and/or the second container thereby ensuring that there is crosslinked biocompatible polymer throughout the first container and/or the second container;
the ionically crosslinkable biocompatible polymer is a divalent cation crosslinkable biocompatible polymer;
the term “active crosslinker” refers to ions for crosslinking the ionically crosslinkable biocompatible polymer;
and
wherein the first container comprises the first diffusion barrier; the active crosslinker in admixture with the first diffusion barrier is coated on the inner surface of the first container;
wherein the first container comprises the first diffusion barrier; the active crosslinker and the first diffusion barrier are coated on an inner surface of the first container in separate layers thereby forming an inner surface layer and an intermediate layer, the intermediate layer comprising the active crosslinker;
wherein the first container comprises the second diffusion barrier and is made from a first polymer material; i) the active crosslinker, ii) the active crosslinker embedded or encapsulated within a second polymer material, or iii) a mixture of i) and ii) being extruded into the first polymer material during production of the first container; the second diffusion barrier being the first polymer material, the second polymer material or a combination thereof; or
wherein the first container comprises the second diffusion barrier and is made from a first polymer material; a third polymer material in admixture with i) the active crosslinker, ii) the active crosslinker embedded or encapsulated within a second polymer material, or iii) a mixture of i) and ii) being co-extruded with the first polymer material during production of the first container thereby forming an inner surface layer and an outer surface layer, the inner surface layer comprising the active crosslinker; and the second diffusion barrier being the second polymer material, the third polymer material or a combination thereof.