Patent ID: 11897880
Assignee: JANSSEN PHARMACEUTICA NV
Field: Organic fine chemistry (Chemistry)
Classification: CPC C | IPC C

Claim 9:
10. The compound of claim 5, selected from the group consisting of
(R*)-12-(5-(1H-benzo[d]imidazol-5-yl)-1H-imidazol-2-yl)-7-chloro-8-fluoro-13,14-dihydro-2H-spiro[benzo[5,6]azocino[4,3-g]indolizine-3,1′-cyclopropane]-1,10(4H,12H)-dione,
(S*)-12-(5-(1H-indol-5-yl)-1H-imidazol-2-yl)-7-chloro-8-fluoro-13,14-dihydro-2H-spiro[benzo[5,6]azocino[4,3-g]indolizine-3,1′-cyclopropane]-1,10(4H,12H)-dione;
(S)-12-(5-(6-amino-2-fluoropyridin-3-yl)-1H-imidazol-2-yl)-7-chloro-8-fluoro-13,14-dihydro-2H-spiro[benzo[5,6]azocino[4,3-g]indolizine-3,1′-cyclopropane]-1,10(4H,12H)-dione;
(S*)-12-(5-(6-amino-2-chloropyridin-3-yl)-1H-imidazol-2-yl)-7-chloro-8-fluoro-13,14-dihydro-2H-spiro[benzo[5,6]azocino[4,3-g]indolizine-3,1′-cyclopropane]-1,10(4H,12H)-dione;
(R*)-12-(5-(6-amino-2-chloropyridin-3-yl)-1H-imidazol-2-yl)-7-chloro-8-fluoro-3,4,13,14-tetrahydrobenzo[5,6]azocino[4,3-g]indolizine-1,10(2H,12H)-dione;
(S*)-12-(5-(6-amino-2-fluoropyridin-3-yl)-1H-imidazol-2-yl)-7-chloro-8-fluoro-3,3-dimethyl-3,4,13,14-tetrahydrobenzo[5,6]azocino[4,3-g]indolizine-1,10(2H,12H)-dione;
(S*)-12-(5-(6-amino-2-fluoropyridin-3-yl)-1H-imidazol-2-yl)-7-chloro-8-fluoro-13,14-dihydro-2H-spiro[benzo[5,6]azocino[4,3-g]indolizine-3,1′-cyclobutane]-1,10(4H,12H)-dione;
(S*)-12-(5-(6-amino-2-fluoropyridin-3-yl)-1H-imidazol-2-yl)-7-chloro-8-fluoro-13,14-dihydro-2H-spiro[benzo[5,6]azocino[4,3-g]indolizine-3,1′-cyclopentane]-1,10(4H,12H)-dione;
(S*)-12-(5-(6-amino-2-fluoropyridin-3-yl)-1H-imidazol-2-yl)-7-chloro-8-fluoro-2-methyl-13,14-dihydro-2H-spiro[benzo[5,6]azocino[4,3-g]indolizine-3,1′-cyclopropane]-1,10(4H,12H)-dione;
methyl (S*)-(4-(2-(1-(11-chloro-12-fluoro-2,5-dioxo-2,5,6,8-tetrahydro-3H-spiro[benzo[e]pyrido[3,4-c]azocine-7,1′-cyclopropan]-3-yl)-2-cyclopropylethyl)-1H-imidazol-5-yl)phenyl)carbamate;
and pharmaceutically acceptable salt thereof.