Patent ID: 11906508
Assignee: AGILENT TECHNOLOGIES, INC.
Field: Measurement (Instruments)
Classification: CPC G | IPC G

Claim 15:
16. A system for continuously monitoring cells in real time, label free, with impedance-based analysis, the system comprising:
a) a plurality of analog-to-digital (A2D) signal converters electrically arranged in parallel to one another;
b) a well plate comprising a plurality of wells on a nonconductive substrate, wherein each well of the plurality of wells comprises one electrode array of a plurality of electrode arrays disposed on the nonconductive substrate that is connected to the plurality of A2D signal converters;
c) an impedance analyzer connected to or including the plurality of A2D signal converters, wherein the impedance analyzer measures, via digitally converted signals from the A2D signal converters, a first plurality of cell-substrate impedances at a first time and a second plurality of cell-substrate impedances at a second time, the first plurality of cell-substrate impedances and the second plurality of cell-substrate impedances being measured between a first electrode structure and a second electrode structure in each electrode array and across a cell sample attached within each well of the plurality of wells; and
d) a software program that analyzes the first plurality of cell-substrate impedances from the first time and the second plurality of cell-substrate impedances from the second time to produce a plurality of time period analyses of the plurality of cell samples, wherein individual time period analyses of the plurality of time period analyses are associated with individual wells of the plurality of wells.