Patent ID: 11932679
Assignee: NAGOYA INSTITUTE OF TECHNOLOGY
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A method for treating or preventing a retinal disease in a subject in need therefor or at risk, comprising the step of administering to said subject an effective amount of a nucleic acid molecule comprising a nucleic acid sequence, wherein the nucleic acid sequence encodes a chimeric protein comprising an amino acid sequence of an ion transport receptor rhodopsin derived from a microorganism of the Gloeobacter genus and an amino acid sequence of a bovine or human derived G protein-coupled receptor rhodopsin, wherein the chimeric protein comprises an amino acid sequence wherein at least a portion of at least one of a second loop on the cytoplasm side and a third loop on the cytoplasm side of the amino acid sequence of the microorganism derived ion transport receptor rhodopsin is substituted with an amino acid sequence of at least a portion of at least one of a second loop on the cytoplasm side and a third loop on the cytoplasm side of the G protein-coupled receptor rhodopsin, wherein the nucleic acid sequence encodes the amino acid sequence of any one of SEQ ID NOs: 1 to 3.