Patent ID: 11926862
Assignee: EUROPEAN MOLECULAR BIOLOGY LABORATORY
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A  Y | IPC A  C

Claim 0:
1. A method for selecting at least two drugs having a synergistic antibacterial effect on a bacterium in a human, the method comprising:
a) providing said bacterium to be tested for said antibacterial effect;
b) providing at least two drugs, wherein a first drug is known to have an antibacterial effect on said bacterium of a) in a human, and wherein a second drug is selected from:
(i) an antibiotic, or a pharmaceutically acceptable salt thereof, wherein said antibiotic is known to belong to the same class selected from the group consisting of an aminoglycoside, a macrolide, a penicillin, a tetracycline, a lincosamide, a quinolone, a fluoroquinolone, a beta-lactam, a polymixin, a monobactam, a glycylcycline, an ansamycin, a sulphonamide, an oxazolidinone, a carbacefem, a carbapenem, a cephalosporine, a strepotogramin, a glycopeptide, a polypeptide, an arsphenamine, chloramphenicol, clindamycin, lincomycin, daptomycin, trimethoprim, novobiocin, ethambutol, fosfomycine, fusidic acid, furazolidone, isoniazid, linezolide, metronidazole, mupirocin, nitrofurantoin, platensimycine, pyrazinamide, quinupristine, dalfopristine, rifampine, a rifamycin, tinidazole, viomycin, and capreomycin, or a pharmaceutically acceptable salt thereof, and/or to target the same bacterial cellular process as the first drug; or
(ii) other human-targeted drug, other food additive, or a pharmaceutically acceptable salt thereof;

c) identifying said at least two drugs after detecting a synergistic antibacterial effect of the at least two drugs as provided in step b) in said bacterium by a Bliss independent model, wherein said identified at least two drugs are selected from Table 1; and
d) selecting said at least two drugs as identified in step c) for combining, as having a synergistic antibacterial effect on the bacterium in the human.