Patent ID: 11859000
Assignee: VACCINEX, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 9:
10. The antibody or antigen-binding portion thereof of claim 6, wherein the bispecific antibody, the BiTe, the multispecific antibody, or the biparatopic antibody comprises (i) a first VH domain, comprising a first VH CDR1, a first VH CDR2, and a first VH CDR3; (ii) a first VL domain, comprising a first VL CDR1, a first VL CDR2, and a first VL CDR3; (iii) a second VH domain, comprising a second VH CDR1, a second VH CDR2, and a second VH CDR3; and (iv) a second VL domain, comprising a second VL CDR1, a second VL CDR2, and a second VL CDR3; wherein
(a) the first VH CDR1 comprises the amino acid sequence set forth in SEQ ID NOs: 45, the first VH CDR2 comprises the amino acid sequence set forth in SEQ ID NO: 46, the first VH CDR3 comprises the amino acid sequence set forth in SEQ ID NO: 47, the first VL CDR1 comprises the amino acid sequence set forth in SEQ ID NO: 48, the first VL CDR2 comprises the amino acid sequence set forth in SEQ ID NO: 49, and the first VL CDR3 comprises the amino acid sequence set forth in SEQ ID NO: 50;
(b) the first VH CDR1 comprises the amino acid sequence set forth in SEQ ID NO: 105, the first VH CDR2 comprises the amino acid sequence set forth in SEQ ID NO: 106, the first VH CDR3 comprises the amino acid sequence set forth in SEQ ID NO: 107, the first VL CDR1 comprises the amino acid sequence set forth in SEQ ID NO: 108, the first VL CDR2 comprises the amino acid sequence set forth in SEQ ID NO: 109, and the first VL CDR3 comprises the amino acid sequence set forth in SEQ ID NO: 110;
(c) the first VH CDR1 comprises the amino acid sequence set forth in SEQ ID NO: 115, the first VH CDR2 comprises the amino acid sequence set forth in SEQ ID NO: 116, the first VH CDR3 comprises the amino acid sequence set forth in SEQ ID NO: 117, the first VL CDR1 comprises the amino acid sequence set forth in SEQ ID NO: 118, the first VL CDR2 comprises the amino acid sequence set forth in SEQ ID NO: 119, and the first VL CDR3 comprises the amino acid sequence set forth in SEQ ID NO: 120;
(d) the first VH CDR1 comprises the amino acid sequence set forth in SEQ ID NO: 135, the first VH CDR2 comprises the amino acid sequence set forth in SEQ ID NO: 136, the first VH CDR3 comprises the amino acid sequence set forth in SEQ ID NO: 137, the first VL CDR1 comprises the amino acid sequence set forth in SEQ ID NO: 138, the first VL CDR2 comprises the amino acid sequence set forth in SEQ ID NO: 139, and the first VL CDR3 comprises the amino acid sequence set forth in SEQ ID NO: 140; or
(e) the first VH CDR1 comprises the amino acid sequence set forth in SEQ ID NO: 145, the first VH CDR2 comprises the amino acid sequence set forth in SEQ ID NO: 146, the first VH CDR3 comprises the amino acid sequence set forth in SEQ ID NO: 147, the first VL CDR1 comprises the amino acid sequence set forth in SEQ ID NO: 148, the first VL CDR2 comprises the amino acid sequence set forth in SEQ ID NO: 149, and the first VL CDR3 comprises the amino acid sequence set forth in SEQ ID NO: 150;, and wherein:
(f) the second VH CDR1 comprises the amino acid sequence set forth in SEQ ID NOs: 5, the second VH CDR2 comprises the amino acid sequence set forth in SEQ ID NO: 6, the second VH CDR3 comprises the amino acid sequence set forth in SEQ ID NO: 7, the second VL CDR1 comprises the amino acid sequence set forth in SEQ ID NO: 8, the second VL CDR2 comprises the amino acid sequence set forth in SEQ ID NO: 9, and the second VL CDR3 comprises the amino acid sequence set forth in SEQ ID NO: 10;
(g) the second VH CDR1 comprises the amino acid sequence set forth in SEQ ID NO: 15, the second VH CDR2 comprises the amino acid sequence set forth in SEQ ID NO: 15, the second VH CDR3 comprises the amino acid sequence set forth in SEQ ID NO: 15, the second VL CDR1 comprises the amino acid sequence set forth in SEQ ID NO: 18, the second VL CDR2 comprises the amino acid sequence set forth in SEQ ID NO: 19, and the second VL CDR3 comprises the amino acid sequence set forth in SEQ ID NO: 20;
(h) the second VH CDR1 comprises the amino acid sequence set forth in SEQ ID NO: 25, the second VH CDR2 comprises the amino acid sequence set forth in SEQ ID NO: 26, the second VH CDR3 comprises the amino acid sequence set forth in SEQ ID NO: 27, the second VL CDR1 comprises the amino acid sequence set forth in SEQ ID NO: 28, the second VL CDR2 comprises the amino acid sequence set forth in SEQ ID NO: 29, and the second VL CDR3 comprises the amino acid sequence set forth in SEQ ID NO: 30;
(i) the second VH CDR1 comprises the amino acid sequence set forth in SEQ ID NO: 35, the second VH CDR2 comprises the amino acid sequence set forth in SEQ ID NO: 36, the second VH CDR3 comprises the amino acid sequence set forth in SEQ ID NO: 37, the second VL CDR1 comprises the amino acid sequence set forth in SEQ ID NO: 38, the second VL CDR2 comprises the amino acid sequence set forth in SEQ ID NO: 39, and the second VL CDR3 comprises the amino acid sequence set forth in SEQ ID NO: 40;
(j) the second VH CDR1 comprises the amino acid sequence set forth in SEQ ID NO: 55, the second VH CDR2 comprises the amino acid sequence set forth in SEQ ID NO: 56, the second VH CDR3 comprises the amino acid sequence set forth in SEQ ID NO: 57, the second VL CDR1 comprises the amino acid sequence set forth in SEQ ID NO: 58, the second VL CDR2 comprises the amino acid sequence set forth in SEQ ID NO: 59, and the second VL CDR3 comprises the amino acid sequence set forth in SEQ ID NO: 60;
(k) the second VH CDR1 comprises the amino acid sequence set forth in SEQ ID NO: 65, the second VH CDR2 comprises the amino acid sequence set forth in SEQ ID NO: 66, the second VH CDR3 comprises the amino acid sequence set forth in SEQ ID NO: 67, the second VL CDR1 comprises the amino acid sequence set forth in SEQ ID NO: 68, the second VL CDR2 comprises the amino acid sequence set forth in SEQ ID NO: 69, and the second VL CDR3 comprises the amino acid sequence set forth in SEQ ID NO: 70;
(l) the second VH CDR1 comprises the amino acid sequence set forth in SEQ ID NO: 75, the second VH CDR2 comprises the amino acid sequence set forth in SEQ ID NO: 76, the second VH CDR3 comprises the amino acid sequence set forth in SEQ ID NO: 77, the second VL CDR1 comprises the amino acid sequence set forth in SEQ ID NO: 78, the second VL CDR2 comprises the amino acid sequence set forth in SEQ ID NO: 79, and the second VL CDR3 comprises the amino acid sequence set forth in SEQ ID NO: 80;
(m) the second VH CDR1 comprises the amino acid sequence set forth in SEQ ID NO: 85, the second VH CDR2 comprises the amino acid sequence set forth in SEQ ID NO: 86, the second VH CDR3 comprises the amino acid sequence set forth in SEQ ID NO: 87, the second VL CDR1 comprises the amino acid sequence set forth in SEQ ID NO: 88, the second VL CDR2 comprises the amino acid sequence set forth in SEQ ID NO: 89, and the second VL CDR3 comprises the amino acid sequence set forth in SEQ ID NO: 90;
(n) the second VH CDR1 comprises the amino acid sequence set forth in SEQ ID NO: 95, the second VH CDR2 comprises the amino acid sequence set forth in SEQ ID NO: 96, the second VH CDR3 comprises the amino acid sequence set forth in SEQ ID NO: 97, the second VL CDR1 comprises the amino acid sequence set forth in SEQ ID NO: 98, the second VL CDR2 comprises the amino acid sequence set forth in SEQ ID NO: 99, and the second VL CDR3 comprises the amino acid sequence set forth in SEQ ID NO: 100;
(o) the second VH CDR1 comprises the amino acid sequence set forth in SEQ ID NO: 125, the second VH CDR2 comprises the amino acid sequence set forth in SEQ ID NO: 126, the second VH CDR3 comprises the amino acid sequence set forth in SEQ ID NO: 127, the second VL CDR1 comprises the amino acid sequence set forth in SEQ ID NO: 128, the second VL CDR2 comprises the amino acid sequence set forth in SEQ ID NO: 129, and the second VL CDR3 comprises the amino acid sequence set forth in SEQ ID NO: 130;
(p) the second VH CDR1 comprises the amino acid sequence set forth in SEQ ID NO: 155, the second VH CDR2 comprises the amino acid sequence set forth in SEQ ID NO: 156, the second VH CDR3 comprises the amino acid sequence set forth in SEQ ID NO: 157, the second VL CDR1 comprises the amino acid sequence set forth in SEQ ID NO: 158, the second VL CDR2 comprises the amino acid sequence set forth in SEQ ID NO: 159, and the second VL CDR3 comprises the amino acid sequence set forth in SEQ ID NO: 160; or
(q) the second VH CDR1 comprises the amino acid sequence set forth in SEQ ID NO: 165, the second VH CDR2 comprises the amino acid sequence set forth in SEQ ID NO: 166, the second VH CDR3 comprises the amino acid sequence set forth in SEQ ID NO: 167, the second VL CDR1 comprises the amino acid sequence set forth in SEQ ID NO: 168, the second VL CDR2 comprises the amino acid sequence set forth in SEQ ID NO: 169, and the second VL CDR3 comprises the amino acid sequence set forth in SEQ ID NO: 170.