Patent ID: 11957667
Assignee: NATIONAL HEALTH RESEARCH INSTITUTES
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  Y | IPC A

Claim 0:
1. A method for inhibiting a positive strand RNA virus, the method comprising:
identify a subject infected with the positive strand RNA virus, and
administering to the subject an effective amount of a compound of Formula II:, wherein
each of R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10, independently, is H, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, halo, nitro, cyano, —ORa, —OC(O)Ra, —C(O)ORa, —NRaRb, —NRaC(O)Rb, or —C(O)NRaRb, each of Ra and Rb, independently, being H, alkyl, aryl, heteroaryl, cycloalkyl, or heterocycloalkyl;
XY, together, is C(R′)(R″)—N or CR′═N+, in which R′ is H, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, halo, nitro, or cyano, and R″ is H, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, halo, nitro, cyano, —ORc, or —OC(O)Rc, Rc being H, alkyl, aryl, heteroaryl, cycloalkyl, or heterocycloalkyl;
A is H, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl;
 is a single bond or a double bond; and
the positive strand RNA virus is a Zika virus or a Dengue virus.