Patent ID: 11972621
Assignee: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
Field: Computer technology (Electrical engineering)
Classification: CPC G | IPC G

Claim 7:
8. A system, comprising: one or more processors coupled to a computer readable memory having stored thereon software instructions that, when executed by the one or more processors, cause the one or more processors to perform or control performance of operations including: scanning one or more stained tissue slides to generate a plurality of tissue slide images including a first tissue slide image of a first tissue slide stained with a first stain and a second tissue slide image of the first tissue slide stained with a second stain, wherein the first stain and the second stain have a common attribute; preprocessing the plurality of tissue slide images; performing an image registration process on the plurality of tissue slide images, wherein the image registration process is performed on the plurality of tissue slide images using an image of the common attribute in each of the plurality of tissue slide images and wherein the image registration process includes: minimizing a mutual information metric between deconvolved hematoxylin channels for first images of slides stained with the first stain and second images of slides stained with the second stain, where the minimizing is performed in two stages: at a first stage, performing a coarse, low-resolution registration of hematoxylin channels using global rigid and affine transforms; and
at a second stage, performing a high-resolution registration of localized fields using affine and B-spline transforms; identifying one or more candidate regions of interest (ROIs) within the plurality of tissue slide images; and generating one or more label annotations for structures within the plurality of tissue slide images.