Patent ID: 11945839
Assignee: HOFFMANN-LA ROCHE, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC C

Claim 4:
5. The method according to claim 2, wherein said multispecific CrossMab antibody is a multispecific antibody comprising
(a) a first antigen binding region specifically binding to a first antigen, wherein the first antigen binding region comprises the light chain and heavy chain of an antibody specifically binding to a first antigen, and
(b) a second antigen binding region specifically binding to a second antigen, wherein the second antigen binding region comprises the light chain and heavy chain of an antibody specifically binding to a second antigen, wherein in the second antigen binding region
(i) the constant domains CL and CH1 are replaced by each other, and/or
(ii) the constant domains VL and VH are replaced by each other.