Patent ID: 11958847
Assignee: KING FAISAL UNIVERSITY
Field: Organic fine chemistry (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 1:
2. A method of treating a PPAR-mediated disease or condition in a patient, comprising administering to a patient in need thereof a therapeutically effective amount of a compound selected from the group consisting of:
N-(6-chlorobenzo[d]thiazol-2-yl)-2-(4-((3,5-dioxopyrazolidin-4-ylidene)methyl) phenoxy)acetamide (1);
2-(4-((3,5-dioxopyrazolidin-4-ylidene)methyl)phenoxy)-N-(6-(trifluoromethyl) benzo[d]thiazol-2-yl)acetamide (2);
2-(4-((3,5-dioxopyrazolidin-4-ylidene)methyl)phenoxy)-N-(6-(trifluoromethoxy) benzo[d]thiazol-2-yl)acetamide (3);
N-(6-chloro-5-methylbenzo[d]thiazol-2-yl)-2-(4-((3,5-dioxopyrazolidin-4-ylidene) methyl)phenoxy)acetamide (4);
N-(6-chloro-5-ethylbenzo[d]thiazol-2-yl)-2-(4-((3,5-dioxopyrazolidin-4-ylidene) methyl)phenoxy)acetamide (5);
N-(6-chloro-7-methylbenzo[d]thiazol-2-yl)-2-(4-((3,5-dioxopyrazolidin-4-ylidene) methyl)phenoxy)acetamide (6);
N-(4-chloro-6-fluorobenzo[d]thiazol-2-yl)-2-(4-((3,5-dioxopyrazolidin-4-ylidene) methyl)phenoxy)acetamide (7);
N-(6-chlorobenzo[d]thiazol-2-yl)-3-(4-((3,5-dioxopyrazolidin-4-ylidene) methyl)phenoxy)propanamide (8);
3-(4-((3,5-dioxopyrazolidin-4-ylidene)methyl)phenoxy)-N-(6-(trifluoromethyl) benzo[d]thiazol-2-yl)propanamide (9);
3-(4-((3,5-dioxopyrazolidin-4-ylidene)methyl)phenoxy)-N-(6-(trifluoromethoxy) benzo[d]thiazol-2-yl)propanamide (10);
N-(6-chloro-5-methylbenzo[d]thiazol-2-yl)-3-(4-((3,5-dioxopyrazolidin-4-ylidene) methyl)phenoxy)propanamide (11);
N-(6-chloro-5-ethylbenzo[d]thiazol-2-yl)-3-(4-((3,5-dioxopyrazolidin-4-ylidene) methyl)phenoxy)propanamide (12);
N-(6-chloro-7-methylbenzo[d]thiazol-2-yl)-3-(4-((3,5-dioxopyrazolidin-4-ylidene) methyl)phenoxy)propanamide (13);
N-(4-chloro-6-fluorobenzo[d]thiazol-2-yl)-3-(4-((3,5-dioxopyrazolidin-4-ylidene) methyl)phenoxy)propanamide (14);
and a pharmaceutically acceptable salt, ester, stereoisomer, or solvate thereof;
wherein the PPAR-mediated disease or condition is selected from the group consisting of diabetes, obesity, hyperglycemia, metabolic syndrome, atherosclerosis, and hyperlipidemia.