Patent ID: 11866467
Assignee: THE UNIVERSITY COURT OF THE UNIVERSITY OF GLASGOW
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. An isolated, non-glycosylated polypeptide comprising an amino acid sequence having at least 95% sequence identity with amino acid sequences of each of domain 1, domain 2 and domain 3 of a TGM protein selected from the group consisting of
TGM (SEQ ID NO: 20);
TGM-a (SEQ ID NO: 23); and
TGM-d (SEQ ID NO: 32);, wherein said polypeptide has TGF-β receptor agonist activity, and each glycosylation site present in the sequence has been mutated, such that said mutated polypeptide is in non-glycosylated form.