Patent ID: 11911479
Assignee: nan
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 6:
7. A method for making a crosslinked composition, the method comprising:
forming a mixture comprising:
an anionic polysaccharide comprising a plurality of thiol groups and having a thiol modification of about 0.1 to about 0.4 μmol thiol per mg of polysaccharide, and
a molecule comprising poly(ethylene glycol) and having at least two thiol-reactive sites, wherein the molar ratio of the thiol groups to the thiol-reactive sites is at least 2:1; and

crosslinking the anionic polysaccharide and the poly(ethylene glycol) at a pH between about 3.2 and about 5.0,
wherein the crosslinked composition comprises about 0.05 to about 0.2 μmol uncrosslinked thiol groups per mg of the anionic polysaccharide.