Patent ID: 11972871
Assignee: DASSAULT SYSTEMES
Field: Medical technology (Instruments)
Classification: CPC G | IPC G

Claim 13:
14. A system comprising:
a processor; and
a memory, the memory having recorded thereon a computer program, including instructions for assisting determining a treatment to be administered to a patient having a tumor configured so that when executed by the processor, the program causes the processor to be configured to:
obtain a plurality of treatment types, the plurality of treatment types comprising one or more targeted treatments, one or more general treatments and/or one or more combinations of targeted treatments and/or general treatments;
for each treatment type of the plurality:
simulate, taking into account the type of treatment, evolution of the tumor associated with an oncogene, the processor being further configured to simulate the evolution by being further configured to:
obtain a plurality of pieces of data each corresponding to a given cell of the tumor, each piece of data including a degree of activation of an oncogene in the given cell, and obtain a model configured to take as an input one of the pieces of data and to output information related to proliferation of the respective given cell corresponding to the input one of the pieces of data, the information on proliferation depending on the degree of activation of the oncogene in the respective given cell and on the treatment type,
wherein the model is decision-based and includes, relative to the respective given cell:
a decision on death or survival,
a decision on absence or presence of division, and
a decision on acquisition of one or more new alterations during a division, and

wherein the model is further configured to take into account the treatment type when determining if a cell corresponding to a piece of data taken as input survives,
run the model on one or more pieces of data of the plurality of pieces of data, and
update the plurality of pieces of data based on the result of the running, and

compute a percentage of tumor evolution based on the evolution simulated for the treatment type, and

output information on the evolution of the tumor simulated for each treatment type including the computed percentage of tumor evolution.