Patent ID: 11965892
Assignee: BIONTECH US INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC G  A  C | IPC A  C  G

Claim 17:
18. The method of claim 1, wherein the presentation PPV determination method comprises processing amino acid information of a plurality of test peptide sequences to generate a plurality of test presentation predictions, each test presentation prediction indicative of a presentation likelihood that a test peptide sequence of the plurality of test peptide sequences is presented by an MHC protein expressed in cells,
wherein the plurality of test peptide sequences comprises at least 5,000 test peptide sequences comprising:
(i) at least one hit peptide sequence identified by mass spectrometry to be presented by an MHC protein expressed in cells, and
(ii) at least 4,999 decoy peptide sequences contained within a protein encoded by a genome of a human,
wherein the plurality of test peptide sequences comprises a ratio of 1:4,999 of the at least one hit peptide sequence to the at least 4,999 decoy peptide sequences, and wherein a top 0.2% of the plurality of test peptide sequences are predicted to be presented by the MHC protein expressed in cells by the trained machine learning immunoprecipitated HLA-peptide presentation prediction model.