Patent ID: 11918822
Assignee: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
Field: Medical technology (Instruments)
Classification: CPC A  C | IPC A  C

Claim 0:
1. A method of enhancing a cell response to a high frequency, low magnitude physical stimulus, the method comprising:
providing an ex vivo cell;
providing a device configured to deliver the high frequency, low magnitude physical stimulus toward the ex vivo cell;
exposing the ex vivo cell to the physical stimulus, wherein the physical stimulus is applied to the ex vivo cell for a first session comprising about one second to about one hour;
providing for a refractory period wherein the same ex vivo cell is free of the physical stimulus for about the next 1-3 hours; and
exposing the same ex vivo cell to the physical stimulus for a second session comprising about one second to about one hour immediately after the about 1-3 hours of being free of the physical stimulus, wherein the response is enhanced relative to an ex vivo cell receiving the same stimulus without the refractory period, wherein a response by the ex vivo cell to the physical stimulus is an increase in cellular proliferation.