Patent ID: 11971404
Assignee: THE BRIGHAM AND WOMEN'S HOSPITAL
Field: nan (nan)
Classification: CPC nan | IPC B  C  G

Claim 0:
1. A method of distinguishing states of a complex biological sample of a subject using a plurality of particles having surfaces with different physicochemical properties, wherein the method comprises:
exposing the complex biological sample to the plurality of particles to permit binding of proteins of the complex biological sample to the plurality of particles to allow a plurality of biomolecule coronas to form on the plurality of particles, wherein a pattern of binding of proteins amongst the plurality of particles differs based on the different physicochemical properties of the surfaces of the plurality of particles;
analyzing the pattern of binding of proteins to define a biomolecule fingerprint representative of proteins that bind to the plurality of particles; and
associating the biomolecule fingerprint with a biological state of the subject.