Patent ID: 11873484
Assignee: MICROSOFT TECHNOLOGY LICENSING, LLC
Field: Biotechnology (Chemistry)
Classification: CPC C  B  G | IPC B  C  G

Claim 14:
15. A system for selectively assembling an oligonucleotide, the system comprising:
a microelectrode array coated with a plurality of anchor sequences;
a reaction chamber containing the microelectrode array;
a first fluid delivery pathway configured to introduce a first oligonucleotide complex encoding a first arbitrary value into the reaction chamber;
control circuitry configured to selectively activate a first subset of electrodes in the microelectrode array to attract the first oligonucleotide complex to the first subset of electrodes having attached thereto a first subset of anchor sequences;
a second fluid delivery pathway configured to introduce a second oligonucleotide complex encoding a second arbitrary value into the reaction chamber;
the control circuitry further configured to selectively activate a second subset of electrodes in the microelectrode array to attract the second oligonucleotide complex to the second subset of electrodes having attached thereto a second subset of anchor sequences; and
a third fluid delivery pathway configured to introduce a reagent to close nicks in assembled double-stranded oligonucleotides attached to the microelectrode array, the assembled double-stranded oligonucleotides formed at least in part by hybridization of the first oligonucleotide complex to the first subset of anchor sequences or by hybridization of the second oligonucleotide complex to the second subset of anchor sequences.