Patent ID: 11891454
Assignee: ICHNOS SCIENCES SA
Field: Biotechnology (Chemistry)
Classification: CPC C | IPC C

Claim 7:
8. The hetero-dimeric immunoglobulin or fragment thereof of claim 1 comprising a heavy chain variable framework region and a light chain variable framework region, wherein the heavy chain variable framework region comprises an amino acid substitution selected from the group consisting of: I34M, V48I, A49G, R58N/Y, I69L, A71T and T73K, according to Kabat numbering and the light chain variable framework region comprises an amino acid substitution selected from the group consisting of: M4L, V33M, A34N, L46R, L47W, R66G, F71Y and P96F, according to Kabat numbering; or wherein the heavy chain variable framework region comprises the amino acid substitutions I34M, A49G and A71T, according to Kabat numbering and the light chain variable framework region comprises the amino acid substitutions M4L, L46R, L47W and F71Y, according to Kabat numbering.