Patent ID: 11859242
Assignee: CARNEGIE MELLON UNIVERSITY
Field: Measurement (Instruments)
Classification: CPC C  G | IPC C  G

Claim 5:
6. The genetic recognition reagent of claim 1, having the structure:, where,
each R is independently, a nucleobase of the plurality of nucleobases;
n is 1, 2, 3, 4, 5, or 6;
R1 and R2 are independently: H, a guanidine-containing group; an amino acid side chain; methyl, ethyl, linear or branched (C3-C8)alkyl, (C2-C8)alkenyl, (C2-C8)alkynyl, (C1-C8)hydroxyalkyl, (C3-C8)aryl, (C3-C8)cycloalkyl, (C3-C8)aryl(C1-C6)alkylene, or (C3-C8)cycloalkyl(C1-C6)alkylene; or a guanidine-containing group, an amino acid side chain, methyl, ethyl, linear or branched (C3-C8)alkyl, (C2-C8)alkenyl, (C2-C8)alkynyl, (C1-C8)hydroxyalkyl, (C3-C8)aryl, (C3-C8)cycloalkyl, (C3-C8)aryl(C1-C6)alkylene, (C3-C8)cycloalkyl(C1-C6)alkylene, wherein the guanidine-containing group, the amino acid side chain, methyl, ethyl, linear or branched (C3-C8)alkyl, (C2-C8)alkenyl, (C2-C8)alkynyl, (C1-C8)hydroxyalkyl, (C3-C8)aryl, (C3-C8)cycloalkyl, (C3-C8)aryl(C1-C6)alkylene, (C3-C8)cycloalkyl(C1-C6)alkylene is substituted with an ethylene glycol unit comprising from 1 to 50 ethylene glycol moieties; —(OCH2—CH2)qOP1; —(OCH2—CH2)q—NHP1; —(SCH2—CH2)q—SP1; —(OCH2—CH2)r—OH; —(OCH2—CH2)r—NH2; —(OCH2—CH2)r—NHC(NH)NH2; or —(OCH2—CH2)r—S—S[CH2CH2]sNHC(NH)NH2, where P1 is H, (C1-C8)alkyl, (C2-C8)alkenyl, (C2-C8)alkynyl, (C3-C8)aryl, (C3-C8)cycloalkyl, (C3-C8)aryl(C1-C6)alkylene or (C3-C8)cycloalkyl(C1-C6)alkylene; q is an integer from 0 to 50; r is an integer from 1 to 50, and s is an integer from 1 to 50; and
one of R4 and R5, and one of R6, R7, and R8 are -L-R3, where each R3 are, independently, two- to five-ring fused polycyclic aromatic moieties, wherein one instance of L is the linker to the first end of the nucleic acid analog backbone, and another instance of L is the linker to the second end of the nucleic acid analog backbone, and each of R4, R5, R6, R7, and R8 that is not -L-R3 are, independently: H, one or more contiguous amino acid residues, a guanidine-containing group, an amino acid side chain, methyl, ethyl, linear or branched (C3-C8)alkyl, (C2-C8)alkenyl, (C2-C8)alkynyl, (C1-C8)hydroxyalkyl, (C3-C8)aryl, (C3-C8)cycloalkyl, (C3-C8)aryl(C1-C6)alkylene, or (C3-C8)cycloalkyl(C1-C6)alkylene; or one or more contiguous amino acid residues, a guanidine-containing group, an amino acid side chain, methyl, ethyl, linear or branched (C3-C8)alkyl, (C2-C8)alkenyl, (C2-C8)alkynyl, (C1-C8)hydroxyalkyl, (C3-C8)aryl, (C3-C8)cycloalkyl, (C3-C8)aryl(C1-C6)alkylene, or (C3-C8)cycloalkyl(C1-C6)alkylene, wherein the one or more contiguous amino acid residues, the guanidine-containing group, the amino acid side chain, methyl, ethyl, linear or branched (C3-C8)alkyl, (C2-C8)alkenyl, (C2-C8)alkynyl, (C1-C8)hydroxyalkyl, (C3-C8)aryl, (C3-C8)cycloalkyl, (C3-C8)aryl(C1-C6)alkylene, or (C3-C8)cycloalkyl(C1-C6)alkylene is substituted with an ethylene glycol unit comprising from 1 to 50 ethylene glycol moieties; —(OCH2—CH2)qOP1; —(OCH2—CH2)q—NHP1; —(SCH2—CH2)q—SP1; —(OCH2—CH2)r—OH; —(OCH2—CH2)r—NH2; —(OCH2—CH2)r—NHC(NH)NH2; or —(OCH2—CH2)r—S—S[CH2CH2]sNHC(NH)NH2, where P1 is H, (C1-C8)alkyl, (C2-C8)alkenyl, (C2-C8)alkynyl, (C3-C8)aryl, (C3-C8)cycloalkyl, (C3-C8)aryl(C1-C6)alkylene or (C3-C8)cycloalkyl(C1-C6)alkylene; q is an integer from 0 to 50; r is an integer from 1 to 50, and s is an integer from 1 to 50,

or a pharmaceutically-acceptable salt thereof.