Patent ID: 11913064
Assignee: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
Field: Measurement (Instruments)
Classification: CPC C  G  B | IPC C  G

Claim 0:
1. An optical gene biosensor comprising:
a substrate;
a molecular beacon anchored to the substrate, wherein the molecular beacon includes an oligonucleotide and a first compound, wherein the oligonucleotide is capable of specifically binding to a target nucleic acid, and wherein the first compound is bound to a first terminal of the oligonucleotide;
an optical marker configured to retro-reflect irradiated light;
a light source for irradiating the optical marker with light; and
a light-receiver for receiving light retro-reflected from the optical marker;
wherein the optical marker includes:
a second compound specifically binding to the first compound, wherein the second compound is coupled to a to-be-modified layer;
a transparent core particle;
a total-reflection inducing layer to cover a portion of a surface of the core particle, wherein the total-reflection inducing layer is made of a material having a refractive index lower than a refractive index of the core particle in a visible light wavelength range of 360 nm to 820 nm;
the to-be-modified layer formed on the total-reflection inducing layer; and
a magnetic layer made of magnetic material, wherein the magnetic layer is placed between the total-reflection inducing layer and the to-be-modified layer.