Patent ID: 11958863
Assignee: SIEMENS HEALTHCARE DIAGNOSTICS INC.
Field: Measurement (Instruments)
Classification: CPC A  C  G | IPC C  G

Claim 4:
5. A method of determining the presence of a macrophilin-binding pharmaceutical in a sample, the method comprising the steps of:
adding to the sample a binding competitor to displace the macrophilin-binding pharmaceutical from its immunophilin complexes, wherein the binding competitor is at least one of:
(a) the compound represented by Formula IV:, (b) the compound represented by Formula V:, (c) the compound represented by Formula VI:, or
(d) the compound represented by Formula VII:, adding a macrophilin-binding pharmaceutical-specific binding partner that binds to the pharmaceutical to form a binding partner/pharmaceutical complex, and wherein the binding partner does not significantly bind to the binding competitor; and
detecting the binding partner/pharmaceutical complex and correlating the detection with an amount of pharmaceutical present in the sample.