Patent ID: 11965164
Assignee: DUKE UNIVERSITY
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 3:
4. A method of treating a disease or disorder in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of the composition comprising an assembly of amphiphilic polynucleotides, each amphiphilic polynucleotide being single-stranded and comprising, in a 5′ to 3′ direction,
an aptamer portion;
a first nucleotide portion comprising a nucleotide sequence of (FdUTP)m (SEQ ID NO:9), wherein m is 100 to 2,000; and
a second nucleotide portion comprising a nucleotide sequence of (Y1)n (SEQ ID NO:11), wherein Y1 is a non-natural hydrophobic nucleotide including a base having a Log P≥1.95, and n is 2 to 10.