Patent ID: 11965025
Assignee: MARENGO THERAPEUTICS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 25:
26. The method of claim 25, wherein
(i) the first Fc region or the second Fc region has:
(a) an Ala at position 180 of SEQ ID NO: 42 (corresponding to an Ala at position 297 in a heavy chain constant region according to EU Numbering)
(b) a Cys at position 232 of SEQ ID NO: 42 (corresponding to a Cys at position 349 in a heavy chain constant region according to EU Numbering),
(c) a Ser at the position 249 of SEQ ID NO: 42 (corresponding to a Ser at position 366 in a heavy chain constant region according to EU Numbering),
(d) an Ala at position 251 of SEQ ID NO: 42 (corresponding to an Ala at position 368 in a heavy chain constant region according to EU Numbering), and
(e) a Val at position 290 of SEQ ID NO: 42 (corresponding to a Val at position 407 in a heavy chain constant region according to EU Numbering); and

(ii) the second Fc region or the first Fc region has:
(a) an Ala at position 97 of SEQ ID NO: 3280 (corresponding to an Ala at position 297 in a heavy chain constant region according to EU Numbering),
(b) a Cys at position 154 of SEQ ID NO: 3280 (corresponding to a Cys at position 354 in a heavy chain constant region according to EU Numbering), and
(c) a Trp at position 166 of SEQ ID NO: 3280 (corresponding to a Trp at position 366 in a heavy chain constant region according to EU Numbering).