Patent ID: 11925617
Assignee: NORTHROP GRUMMAN SYSTEMS CORPORATION
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 0:
1. A method for treating cancer in a patient, the method comprising:
administering to a patient in need of such treatment a therapeutically effective amount of a compound of structural Formula (I):, or a salt thereof,
wherein:
R1, R2, R3 and R4 are each independently hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroaryl, substituted heteroaryl, heteroalkyl, substituted heteroalkyl, heteroarylalkyl, substituted heteroarylalkyl, halo, hydroxyl, or nitro;
each of R5 and R6 are independently hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroaryl, substituted heteroaryl, heteroalkyl, substituted heteroalkyl, heteroarylalkyl, substituted heteroarylalkyl, halo, hydroxy or nitro;
o is 0, 1, 2, 3 or 4;
R7 is a substituted acyl selected from the group consisting of: —C(O)-cycloalkyl, —C(O)-aryl, —C(O)-arylalkyl, —C(O)-heteroaryl, —C(O)-heteroarylalkyl, and —C(O)-alkyl, each of which is substituted by one or more substituents independently selected from the group consisting of halogen, —OR60, —CF3, —OP(O)(OR60)(OR61), and —OP(O)(OH)2;
R60 represents independently for each occurrence alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, heteroaryl, or substituted heteroaryl;
R61 represents independently for each occurrence hydrogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, heteroaryl, or substituted heteroaryl;
provided that at least two of R1, R2, R3, R4, R5 and R6 are nitro; and
the cancer is selected from the group consisting of: stomach cancer, laryngeal cancer, esophageal cancer, parotid cancer, biliary tract cancer, cervical cancer, endometrial cancer, thyroid cancer, squamous cell carcinoma, adenocarcinoma, melanoma, angiosarcoma, chondrosarcoma, small cell carcinoma, glioblastoma multiforme, and neuroendocrine cancer.