Patent ID: 11957763
Assignee: SYNAFFIX B.V.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 0:
1. A compound comprising a target molecule D covalently connected to a reactive group Q′ via a linker represented by the following formula:, wherein:
BM is a branching moiety;
E is a capping group;
SG is a sulfamide group according to formula (1);
b is independently 0 or 1;
c is 0 or 1;
d is 0 or 1;
e is 0 or 1;
f is an integer in the range of 1 to 10;
g is 0 or 1;
i is 0 or 1;
k is 0 or 1;
1 is 0 or 1;
Sp1 is a spacer moiety;
Sp2 is a spacer moiety;
Sp3 is a spacer moiety;
Sp4 is a spacer moiety;
Sp5 is a spacer moiety;
Sp6 is a spacer moiety;
Z1 is a connecting group;
Z2 is a connecting group,

wherein one of the bonds labelled with * is connected to reactive group Q1 and one of the bonds labelled with * is connected to target molecule D, and wherein the sulfamide group SG is represented by formula (1):, wherein
a is 0 or 1; and
R1 is selected from the group consisting of hydrogen, C1-C24 alkyl groups, C3-C24 cycloalkyl groups, C2-C24 (hetero) aryl groups, C3-C24 alkyl (hetero) aryl groups and C3-C24 (hetero) arylalkyl groups, wherein the C1-C24 alkyl groups, C3-C24 cycloalkyl groups, C2-C24 (hetero) aryl groups, C3-C24 alkyl (hetero) aryl groups and C3-C24 (hetero) arylalkyl groups are optionally substituted and optionally interrupted by one or more heteroatoms selected from O, S and NR3 wherein R3 is independently selected from the group consisting of hydrogen and C1-C4 alkyl groups, or R1 is a further target molecule D, wherein the target molecule is optionally connected to N via a spacer moiety, and

wherein one of the bonds labelled with * is connected to the branching moiety, optionally via spacer Sp5, and the other bond labelled with * to a capping group E, optionally via spacer Sp6, and
wherein the target molecule D is selected from the group consisting of active substances, reporter molecules, polymers, solid surfaces, hydrogels, nanoparticles, microparticles and biomolecules; and the reactive group Q1 is selected from the group consisting of, optionally substituted, N-maleimidyl groups, halogenated N-alkylamido groups, sulfonyloxy N-alkylamido groups, ester groups, carbonate groups, sulfonyl halide groups, thiol groups or derivatives thereof, alkenyl groups, alkynyl groups, (hetero)cycloalkynyl groups, bicyclo[6.1.0]non-4-yn-9-yl groups, cycloalkenyl groups, tetrazinyl groups, azido groups, phosphine groups, nitrile oxide groups, nitrone groups, nitrile imine groups, diazo groups, ketone groups, (O-alkyl) hydroxylamino groups, hydrazine groups, halogenated N-maleimidyl groups, 1,1-bis(sulfonylmethyl)methyl-carbonyl groups or elimination derivatives thereof, carbonyl halide groups, allenamide groups, 1,2-quinone groups, and triazine groups.