Patent ID: 11873295
Assignee: PETRA PHARMA CORPORATION
Field: Organic fine chemistry (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 121:
122. A compound of the Formula:, or pharmaceutically acceptable salt thereof, wherein:
R is —H or C1-C3 alkyl;
R1 is a group of the formula:, R2 is a group of the formula:, R3 is halogen, —CN, —N(H)(C1-C3 alkyl), —N(C1-C3 alkyl)2, —N(H)(CH2CH2CO2H), —C(O) C1-C3 alkyl, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 hydroxyalkyl, C3-C5 cycloalkyl, an optionally substituted heterocycle of 3 to 5 ring atoms containing 1, 2, or 3 ring heteroatoms independently selected from N, O, or S, or an optionally substituted heteroaryl of 5 or 6 ring atoms containing 1, 2, or 3 ring heteroatoms independently selected from N, O, or S; wherein the optionally substituted heterocycle or heteroaryl is each optionally substituted with one to three substituents each independently selected from halogen, C1-C3 alkyl, or C1-C3 haloalkyl;
each of R4, R5 and R6 is independently —H, halogen, C1-C6 alkyl or C1-C6 haloalkyl;
R7 is —CN, C1-C6 alkyl or C1-C6 haloalkyl;
R8 is —H or C1-C6 alkyl;
each R9 is independently —H, halogen, —CN, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, or C3-C5 cycloalkyl;
each R10 is independently —H, —CN, halogen, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, —SO2R11, —C(O)OC1-C3 alkyl, —CONR11R11, —NR11R11, —NR11—CO2R11, —OH, an optionally substituted C1-C6 alkyl, an optionally substituted C2-C6 alkenyl, an optionally substituted C2-C6 alkynyl, an optionally substituted C3-C5 cycloalkyl, an optionally substituted heterocycle selected from pyrrolidine, pyrrolidinone, piperidine or morpholine, an optionally substituted phenyl, an optionally substituted 1,3-benzodioxole, an optionally substituted 2,3-dihydro-1,4-benzodioxine, or an optionally substituted heteroaryl selected from pyrazole, isoxazole, isothiazole, imidazole, oxazole, or thiazole; wherein the optionally substituted C1-C6 alkyl, C2-C6 alkenyl, or C2-C6 alkynyl is each optionally substituted with a —CN, —OH, oxetanyl, C1-C3 alkoxy, or —CONR11R11; the optionally substituted C3-C5 cycloalkyl, phenyl, 1,3-benzodioxole, 2,3-dihydro-1,4-benzodioxine, heterocycle or heteroaryl is each optionally substituted with one to three substituents each independently selected from halogen, C1-C3 alkyl, C1-C3 haloalkyl, C1-C3 alkoxy, C1-C3 haloalkoxy, —SO2R11, —NR11R11, —OH or —CN; and
each R11 is independently —H or C1-C3 alkyl.