Patent ID: 11931400
Assignee: PSOMAGEN, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C  G  Y | IPC A  C  G

Claim 3:
4. A therapeutic composition for improving a Toll-like receptor (TLR)-related condition, the therapeutic composition comprising a peptide configured to modulate TLR-related functionality and derived based on reengineering of a target peptide sequence associated with a microorganism-related modulator associated with Rv1168c protein from Mycobacterium tuberculosis, wherein the peptide corresponds to a peptide sequence comprising at least one motif of a set of peptide sequence motifs comprising:
a sixth motif comprising F[X]PPAP[J] (SEQ ID NOS:35254-35269), wherein X in the sixth motif comprises at least one of (P,S), and wherein J in the sixth motif comprises at least one of (P,Y,L,A,E,G,V,I);
a seventh motif comprising DFT[X]FPP (SEQ ID NOS:35270-35271), wherein X in the seventh motif comprises at least one of (V,I);
an eighth motif comprising [X]TPA[J]F[B] (SEQ ID NOS:35272-35283), wherein X in the eight motif comprises at least one of (Y,T,H), wherein J in the eight motif comprises at least one of (H,I), and wherein B in the eight motif comprises at least one of (Y,A); and
a ninth motif comprising [B]AR[X]TP[Z]SPP (SEQ ID NOS:35284-35303), wherein B in the ninth motif comprises at least one of (P,A), wherein X in the ninth motif comprises at least one of (A,P,W,N,L), and wherein Z in the ninth motif comprises at least one of (P,F).