Patent ID: 11926616
Assignee: INCYTE CORPORATION
Field: Organic fine chemistry (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 13:
14. The method of claim 1, wherein the compound of Formula (I) is selected from:
3-amino-6-(2-(methyl-d3)-5-(1,1, 1-tri fluoro-2,3-dihydroxypropan-2-yl)phenyl)-N-(tetrahydro-2H-pyran-4-yl)pyrazine-2-carboxamide;
3-amino-6-(5-(1, 1-difluoro-2, 3-dihydroxypropan-2-yl)-2-(methyl-d3)phenyl)-N-(4-hydroxybicyclo[2.2.1]heptan- 1-yl)pyrazine-2-carboxamide;
3-amino-6-(2-(methyl-d3)-5-(1, 1, 1-trifluoro-2,3-dihydroxybutan-2-yl)phenyl)-N-(tetrahydro-2H-pyran-4-yl)pyrazine-2-carboxamide;
3-amino-6-(2-methyl-5-(1, 1, 1-trifluoro-2, 3-dihydroxy-3-methylbutan-2-yl)phenyl)-N-(tetrahydro-2H-pyran-4-yl)pyrazine-2-carboxamide;
3-amino-N-((1 s,3R)-3-cyanocyclobutyl)-6-(2-(methyl-d3)-5((S)-1, 1, 1-trifluoro-2,3-dihydroxypropan-2-yl)phenyl)pyrazine-2-carboxamide;
3-amino-N-((1s,2S)-2-hydroxycyclohexyl)-6-(2-(methyl-d3)-5((S)-1, 1, 1-trifluoro-2, 3-dihydroxypropan-2-yl)phenyl)pyrazine-2-carboxamide;
3-amino-N-(trans)-3-hydroxytetrahydro-2H-pyran-4-yl)-6-(2-(methyl-d3)-5((S)-1, 1, 1-trifluoro-2,3-dihydroxypropan-2-yl)phenyl)pyrazine-2-carboxamide;
3-amino-N(-1s,3R)-3-hydroxy-3-(trifluoromethyl)cyclobutyl)-6-(2-(methyl-d3)-5-((S)-1,1, 1-trifluoro-2, 3-dihydroxypropan-2-yl)phenyl)pyrazine-2-carboxamide;
3-amino-N-(1s,3R)-3-hydroxy-1-methyl cyclobutyl)-6-(2-(methyl-d3)-5((S)-1, 1, 1-trifluoro-2,3-dihydroxypropan-2-yl)phenyl)pyrazine-2-carboxamide;
(S)-3-amino-N-(4-(hydroxymethyl)bicyclo [2.1.1]hexan-1-yl)-6-(2-(methyl-d3)-5-(1, 1, 1-trifluoro-2,3-dihydroxypropan-2-yl)phenyl)pyrazine-2-carboxamide;
(S)-3-amino-N-(3-(hydroxymethyl)bicyclo [1.1.1]pentan-1-yl)-6-(2-(methyl-d3)-5-(1, 1, 1-trifluoro-2,3-dihydroxypropan-2-yl)phenyl)pyrazine-2-carboxamide;
3-amino-N—((S)-1-hydroxypropan-2-yl)-6-(2-(methyl-d3)-5((S)-1, 1, 1-trifluoro-2, 3-dihydroxypropan-2-yl)phenyl)pyrazine-2-carboxamide;
(S)-3-amino-N-(2-cyano-2-methylpropyl)-6-(2-(methyl-d3)-5-(1,1, 1-trifluoro-2,3-dihydroxypropan-2-yl)phenyl)pyrazine-2-carboxamide;
(S)-3-amino-N-(4-hydroxybicyclo [2.2.1]heptan- 1-yl)-6-(2-(methyl-d3)-5-(1, 1, 1-trifluoro-2,3-dihydroxypropan-2-yl)phenyl)pyrazine-2-carboxamide;
3-amino-N—((R)-1-hydroxypropan-2-yl)-6-(2-(methyl-d3)-5((S)-1, 1, 1-trifluoro-2, 3-dihydroxypropan-2-yl)phenyl)pyrazine-2-carboxamide;
(S)-3-amino-N-(4-hydroxybicyclo[2.1.1]hexan-1-yl)-6-(2-(methyl-d3)-5-(1, 1, 1-trifluoro-2,3-dihydroxypropan-2-yl)phenyl)pyrazine-2-carboxamide;
3-amino-6-(5-((S)-1,1-difluoro-2,3-dihydroxypropan-2-yl)-2-(methyl-d3)phenyl)-N-((1S,2S)-2-hydroxycyclohexyl)pyrazine-2-carboxamide;
3-amino-6-(5-((S)-1,1-difluoro-2,3-dihydroxypropan-2-yl)-2-(methyl-d3)phenyl)-N-((1R,2R)-2-hydroxycyclohexyl)pyrazine-2-carboxamide;
(S)-3-amino-N-(4-cyanobicyclo[2.1.1]hexan-1-yl)-6-(5-(1,1-difluoro-2,3-dihydroxypropan-2-yl)-2-(methyl-d3)phenyl)pyrazine-2-carboxamide;
(S)-3-amino-6-(5-(1,1-difluoro-2,3-dihydroxypropan-2-yl)-2-(methyl-d3)phenyl)-N-(tetrahydro-2H-pyran-4-yl)pyrazine-2-carb oxamide;
(S)-3-amino-6-(5-(1,1-difluoro-2,3-dihydroxypropan-2-yl)-2-methylphenyl)-N-(tetrahydro-2H-pyran-4-yl)pyrazine-2-carb oxamide;
3-amino-6-(5-((S)-1,1-difluoro-2,3-dihydroxypropan-2-yl)-2-methylphenyl)-N—((S)-1-hydroxypropan-2-yl)pyrazine-2-carboxamide;
3-amino-6-(5-(1,1-difluoro-2,3-dihydroxypropan-2-yl)-2-methylphenyl)-N-(4-hydroxybicyclo [2.2.1]heptan-1-yl)pyrazine-2-carboxamide;
(3-amino-6-(5-((S)-1,1-difluoro-2,3-dihydroxypropan-2-yl)-2-methylphenyl)pyrazin-2-yl)((R)-2-(hydroxymethyl)pyrrolidin-1-yl)methanone;
(S)-3-amino-6-(5-(1,1-difluoro-2,3-dihydroxypropan-2-yl)-2-methylphenyl)-N-isopropylpyrazine-2-carboxamide;
3-amino-6-(5-((S)-1,1-difluoro-2,3-dihydroxypropan-2-yl)-2-methylphenyl)-N-(3-methyltetrahydrofuran-3-yl)pyrazine-2-carb oxamide; and
3-amino-N-(4-cyanobicyclo[2.1.1]hexan-1-yl)-6-(5-(1,1-difluoro-2,3-dihydroxypropan-2-yl)-2-methylphenyl)pyrazine-2-carboxamide;
or an enantiomer, diastereomer or tautomer thereof;
or a pharmaceutically acceptable salt thereof.