Patent ID: 11898055
Assignee: UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
Field: Medical technology (Instruments)
Classification: CPC C  A  B | IPC A  B  C

Claim 0:
1. A coated medical implant device, comprising:
a substrate selected from the group comprising magnesium metal, magnesium alloy, iron metal, iron alloy, ferrous metal and ferrous alloy;
a pretreatment agent selected from the group consisting of alkali metal hydroxide, hydrogen fluoride, alkali metal carbonates, and mixtures thereof, applied to a surface of the substrate to form a charged substrate having a positive charge or a negative charge;
a polyelectrolyte multilayer coating deposited on the charged substrate, comprising:
a plurality of interfacing, individual polymer layers, comprising:
at least one polymer layer comprising a first polymer and having a positive charge; and
at least one polymer layer comprising a second polymer and having a negative charge;

wherein an initial polymer layer of the plurality of interfacing, individual polymer layers is deposited on the charged substrate and has a charge opposite the charged substrate, and
wherein an outer polymer layer of the plurality of interfacing, individual polymer layers forms an exterior surface of the charged substrate;
fibronectin immobilized on the exterior surface; and
an active substance, in addition to the fibronectin, deposited on the exterior surface of the charged substrate.