Patent ID: 11945872
Assignee: REGENERON PHARMACEUTICALS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. An isolated antibody or antigen-binding fragment thereof that binds specifically to activin A receptor type 1 (ACVR1) protein and/or a mutant thereof, wherein the antibody or antigen-binding fragment thereof interacts with one or more amino acids contained within the extracellular domain of ACVR1 (amino acids 21-123 of SEQ ID NO: 341), and wherein the antibody or antigen-binding fragment thereof binds to cells expressing full-length ACVR1 protein and/or a mutant thereof,
wherein the antibody or antigen-binding fragment thereof comprises
three heavy chain complementarity determining regions (CDRs) (HCDR1, HCDR2 and HCDR3) contained within a heavy chain variable region (HCVR) comprising the amino acid sequence of SEQ ID NO: 42; and three light chain CDRs (LCDR1, LCDR2 and LCDR3) contained within a light chain variable region (LCVR) comprising the amino acid sequence of SEQ ID NO: 48; or
three heavy chain CDRs (HCDR1, HCDR2 and HCDR3) contained within a HCVR comprising the amino acid sequence of SEQ ID NO: 58; and three light chain CDRs (LCDR1, LCDR2 and LCDR3) contained within a LCVR comprising the amino acid sequence of SEQ ID NO: 62.