Patent ID: 11925463
Assignee: LCM BIOSENSOR TECHNOLOGIES, INC.
Field: Medical technology (Instruments)
Classification: CPC A | IPC A

Claim 0:
1. A method for monitoring blood glucose levels, the method comprising:
applying at least one heat and waterproof applicator to a skin surface with a dosed pressure, forming a closed system in a local area of living tissue under the applicator;
exerting an external physical effect on the local area of the tissue under the applicator, including the dosed pressure;
measuring temporal dynamics of physiological parameters in the local area of the living tissue under the applicator, including at least the temporal dynamics of:
osmotic pressure of an intercellular substance and/or an amount of water in an intercellular space of the tissue under the applicator;
temperature of a dermis under the applicator via radio thermometry or heat flow through a skin area under the applicator via a heat detector; and
elastic pressure of the tissue under the applicator,

measuring values of environmental climatic parameters before beginning the measurement of the temporal dynamics of the physiological parameters, including at least:
room temperature and relative humidity in a measurement room; and
atmosphere pressure,

measuring an external environment temperature or external heat flow through an enclosing structure between the measurement room and an external environment;
calculating a value of enthalpy, H, in a layer of the tissue under the applicator accounting for an influence of the climatic parameters, according to the formula:

H=H0(Tskin, Psensor)xθ(Troom, Text, RHroom, Patm), where

Tskin is the temperature of the dermis,
Psensor is the dosed pressure of the applicator on the skin surface,
Troom is the room temperature,
Text is an ambient air temperature behind the enclosing structure,
RHroom is the relative humidity in the measurement room, and
Patm is the atmospheric pressure; and
calculating changes in blood glucose level based on a thermodynamics equation that connects the enthalpy with thermodynamic variables or variables of a thermodynamic state.