Patent ID: 11932637
Assignee: MERCK SHARP & DOHME LLC
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A compound of Formula I, or a pharmaceutically acceptable salt thereof, wherein:
T is CH, or N, provided that no more than two of T, U and V are N;
U is CH, or N;
V is CH or N;
X is selected from:
1) O, and
2) CH2;

Y is selected from:
1) O,
2) NR8,
3) S, and
4) CH2,

provided that when Y is O, NR8 or S then X is not O;
Z is
1) O,
2) S,
3) CH2, or
4) NH,

provided that when Z is O, S or NH, then X is not O;
W is selected from:
1) bond, and
2) O;

Q is selected from:
1) N, and
2) CR8;

R1 is selected from:
1) —C3-12cycloalkyl,
2) —C3-12cycloalkenyl,
3) —C2-11cycloheteroalkyl,
4) —C2-11cycloheteroalkenyl,
5) aryl, and
6) heteroaryl,

wherein alkyl, cycloalkyl, cycloalkenyl, cycloheteroalkyl, cycloheteroalkenyl, aryl and heteroaryl are unsubstituted or substituted with one to five substituents selected from Ra;
R2 is selected from:
1) hydrogen,
2) —C1-6alkyl,
3) —C1-6alkyl-OR4, and
4) —C1-6alkyl-NHR4,

wherein alkyl is unsubstituted or substituted with one to three halogens;
R3 is selected from:
1) hydrogen, and
2) OH;

R4 is selected from:
1) hydrogen,
2) C1-3alkyl, and
3) C3cycloalkyl,

wherein alkyl and cycloalkyl are unsubstituted or substituted with one to three halogens or OC1-3alkyl;
R5 is selected from:
1) —CO2H, and
2) tetrazole;

R6 and R7 are selected from:
1) hydrogen, and
2) C1-6alkyl,

wherein alkyl is unsubstituted or substituted with one to three halogens, provided that at least one of R6 and R7 is hydrogen;
each R8 is independently selected from:
1) hydrogen,
2) C1-4alkyl,
3) halogen, and
4) C3-7cycloalkyl,

wherein alkyl and cycloalkyl are unsubstituted or substituted with one to three substituents selected from: —OH, halogen, NH2, and —OC1-3alkyl;
R9 and R10 are selected from:
1) hydrogen, and
2) C1-6alkyl,

wherein alkyl is unsubstituted or substituted with one to three substituents selected from:
halogen, OH, —OC1-3alkyl, —NHC(O)C1-3alkyl, —C(O)NHC1-3alkyl, NHC1-3alkyl, and SC1-3alkyl, provided that one or both of R9 and R10 are C1-6alkyl,
or alternatively R9 and R10 together with the carbon to which they are attached form a monocyclic C3-5cycloalkyl or a monocyclic C2-5cycloheteroalkyl, wherein cycloalkyl and cycloheteroalkyl are unsubstituted or substituted with one to three substituents independently selected from halogen, —OH and —OC1-3alkyl;
each Ra is independently selected from:
1)halogen,
2) —C1-6alkyl,
3) —C0-6alkyl-O—C1-6alkyl,
4) —C0-6alkyl-OH,
5) —C0-6alkyl S(O)rRj,
6) —C0-6alkyl S(O)rNRkRl,
7) —C0-6alkyl C(O)Ri,
8) —C0-6alkyl OC(O)Ri,
9) —C0-6alkyl C(O)ORi,
10) —C0-6alkyl CN,
11) —C0-6alkyl C(O)NRkRl,
12) —C0-6alkyl C(NH)NRkRl,
13) —C0-6alkylNRkRl,
14) —C0-6alkyl N(Rk)(C(O)Ri),
15) —C0-6alkyl N(Rk)(C(O)ORh),
16) —C0-6alkyl N(Rk)(C(O)NRfRg), and
17) —C0-6alkyl N(Rk)(S(O)vRj),

wherein alkyl is unsubstituted or substituted with one to three substituents selected from: halogen, OH, —OC1-3alkyl, —C1-3alkyl, —CO2C1-3alkyl, —C(O)NH2, —C0-6alkylNH2, and —C0-6alkylNH(C1-3alkyl);
each Rb is independently selected from:
1) hydrogen,
2) —C1-6alkyl,
3) —C0-6alkyl-O—C1-6alkyl,
4) —C0-6alkyl-OH,
5) —C0-6alkyl-S(O)uRd,
6) —C1-6alkyl-C(O—N(Re)2,
7) —C1-6alkylN(Re)C(O)Re,
8) —C0-6alkyl-N(Re)2, and
9) halogen,

wherein alkyl is unsubstituted or substituted with one to three halogens,
or optionally, two Rb substituents, together with the atoms to which they are attached, can cyclize to form a monocyclic C3-6cycloalkyl or a monocyclic C2-6cycloheteroalkyl ring;
each Rc is independently selected from:
1) hydrogen,
2) —C1-6alkyl,
3) —C0-6alkyl-O—C1-6alkyl,
4) —C0-6alkyl-OH,
5) —C0-6alkyl-S(O)vRf,
6) —C0-6alkyl-S(O)vN(Rg)2,
7) —C1-6alkyl C(O)—N(Rg)2,
8) —C1-6alkylN(Rg)C(O)Rg,
9) —C0-6alkyl-N(Rg)2, and
10) halogen,

wherein alkyl is unsubstituted or substituted with one to three halogens;
each Rd is independently selected from:
1) hydrogen, and
2) —C1-6 alkyl,

wherein each alkyl is unsubstituted or substituted with one to three halogens;
each Re is independently selected from:
1) hydrogen, and
2) —C1-6 alkyl,

wherein each alkyl is unsubstituted or substituted with one to three halogens;
each Rf is independently selected from:
1) hydrogen, and
2) —C1-6alkyl,

wherein each alkyl is unsubstituted or substituted with one to three halogens;
each Rg is independently selected from:
1) hydrogen, and
2) —C1-6 alkyl,

wherein each alkyl is unsubstituted or substituted with one to three halogens;
each Rh is independently selected from:
1) hydrogen, and
2) —C1-6 alkyl,

wherein each alkyl is unsubstituted or substituted with one to three halogens;
each Ri is —C1-6 alkyl, wherein each alkyl is unsubstituted or substituted with one to three halogens;
each Rj is independently selected from:
1) hydrogen,
2) OH, and
3) —C1-6 alkyl,

wherein each alkyl is unsubstituted or substituted with one to three halogens;
each Rk is independently selected from:
1) hydrogen, and
2) —C1-6 alkyl,

wherein each alkyl is unsubstituted or substituted with one to three halogens;
each Rl is independently selected from:
1) hydrogen, and
2) —C1-6 alkyl,

wherein each alkyl is unsubstituted or substituted with one to three halogens;
each r is independently 0, 1 or 2;
each s is independently 0, 1, 2, 3, 4 or 5;
each t is independently 0, 1, 2 or 3;
each u is independently selected from 0, 1 or 2; and
each v is independently selected from 0, 1 or 2.