Patent ID: 11865196
Assignee: XIAMEN UNIVERSITY
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 0:
1. A method for preparing an engineered radioactive polymeric microsphere, comprising:
adding 10 g of a styrene monomer and 1 g of sodium dodecyl sulfate (SDS) to 20 mL of deionized water, followed by stirring at room temperature in a nitrogen atmosphere for 2 h to obtain a first reaction mixture;
heating the first reaction mixture to 50° C. and adding 2 g of dibenzoyl peroxide to the first reaction mixture, followed by reaction under stirring at a constant temperature for 6 h to obtain a second reaction mixture; and
subjecting the second reaction mixture to washing with ethanol and 60° C. water, and vacuum drying to obtain a crude polymeric microsphere;
weighing 3 g of the crude polymeric microsphere followed by irradiation in the exposure to a cobalt source at room temperature under an air atmosphere to obtain an irradiated polymeric microsphere, wherein a radiation absorbed dose is 100 kGy; adding 60 mL of deionized water and 10 mL of vinylphosphonic acid to a conical flask followed by stirring for 1 h to obtain a vinylphosphonic acid solution; adding 3 g of the irradiated polymeric microsphere to the vinylphosphonic acid solution followed by nitrogen feeding for 20 min to remove oxygen and sealing to obtain a third reaction mixture; subjecting the third reaction mixture to reaction in a 55° C. water bath for 3 h and vacuum filtration to obtain a grafted polymeric microsphere; and subjecting the grafted polymeric microsphere to washing with deionized water and drying in a vacuum oven for 24 h to obtain a phosphate-based polymeric microsphere; and
mixing 0.5 g of the phosphate-based polymeric microsphere with 1 mL of a 0.5 mCi/μL 177LuCl3 solution at room temperature under ultrasonic oscillation for 30 min to obtain an engineered phosphate-based 177Lu polymeric microsphere with a diameter of 40 μm.