Patent ID: 11944623
Assignee: AUTIFONY THERAPEUTICS LIMITED
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 15:
16. The method according to claim 4, wherein the modulator of Kv3.1 and/or Kv3.2 and/or Kv3.3 is a compound of formula (I):, wherein:
W is group (Wa), group (Wb), group (Wc) or group (Wd):, wherein:
R1 is H, C1-4alkyl, halo, haloC1-4alkyl, CN, C1-4alkoxy, or haloC1-4alkoxy;
R2 is H, C1-4alkyl, C3-5 spiro carbocyclyl, haloC1-4alkyl or halo;
R3 is H, C1-4alkyl, haloC1-4alkyl, halo; or R3 is absent;
R13 is H, C1-4alkyl, haloC1-4alkyl, halo; or R13 is absent;
R14 is H, C1-4alkyl, haloC1-4alkyl, halo; or R14 is absent;
A is a 5 or 6 membered saturated or unsaturated heterocycle, with at least one O atom; which heterocycle is optionally fused with a cyclopropyl group, or a cyclobutyl group, or a cyclopentyl group to form a tricycle when considered together with the phenyl;
wherein R2 and R3 may be attached to the same or a different ring atom; R2 may be attached to a fused ring atom; and wherein R13 and R14 may be attached to the same or a different ring atom;, wherein:
R16 is halo, C1-4 alkyl, C1-4 alkoxy, halo-C1-4alkyl, halo-C1-4alkoxy, or CN;
R17 is H, halo, cyano, C1-4 alkyl or C1-4 alkoxy; with the proviso that when R17 is H, R16 is not in the para position;, wherein:
R22 is H, Cl, F, C1-4alkyl;
R23 is H, C1-4alkyl, Cl, CF3, O—C1-4alkyl, OCF3 or N(CH3)2;
R24 is H, Cl, F, C1-4alkyl, O—C1-4alkyl, CN, OCF3 or CF3;
R25 is H, Cl, F, O—C1-4alkyl or C1-4alkyl; and
R26 is H or C1-4alkyl;
wherein for R22 to R26, C1-4alkyl may be substituted by O-methyl;
with the provisos that:
not all of R22 to R26 may be H;
when R4 is H, then R23 is methyl or CF3 and R22, R24, R25 and R26 are all H;
when one of R22, R24, R25 or R26 is F, then at least one of R22 to R26 cannot be H or F; and
when R24 is not H, at least one of R22 or R23 is not H;

X is CH or N;
Y is CR15 or N;
R15 is H or C1-4alkyl;

when W is group (Wa), group (Wb) or group (Wc), Z is group (Za):, wherein:
R4 is C1-4 alkyl;
R5 is H or C1-4 alkyl;
or R4 and R5 can be fused to form C3-4 spiro carbocyclyl;

when W is group (Wa), group (Wb) or group (Wd), Z is group (Zb):, wherein:
R4 is H or C1-4 alkyl;

or a pharmaceutically acceptable salt and/or solvate thereof and/or derivative thereof.