Patent ID: 11970687
Assignee: EMD MILLIPORE CORPORATION
Field: Biotechnology (Chemistry)
Classification: CPC C  A | IPC C

Claim 13:
14. A process for treating biological liquid by viral inactivation, using the installation according to claim 1, the process comprising the steps of:
at least partial filling the first main treatment tank with biological liquid to treat of from the first treatment line of the installation via the main supply valve of the installation;
adjusting the pH of the biological liquid by introducing a determined volume of acid and a determined volume of base into the first main treatment tank;
incubating the biological liquid in the first treatment line for a predetermined time and adjusting the pH of the biological liquid in the first treatment line by introducing a determined volume of acid and a determined volume of base into the first treatment line to approach a target pH;
transferring the treated biological liquid into the third main treatment tank of the installation disposed at the second end of the first treatment line;
pre-polishing the biological liquid in the third main treatment tank by introducing a determined volume of acid and a determined volume of base into the third main treatment tank to obtain a final treated biological liquid at the target pH;
whereas at the same time as the above steps of pre-polishing and/or transfer and/or incubation and/or adjustments of pH implemented in the first treatment line, at least partial filling the second treatment tank with biological liquid to treat via the main supply valve, the second treatment line being in parallel with the first treatment line;
adjusting the pH of the biological liquid in the second main treatment tank by introducing a determined volume of acid and a determined volume of base into the second main treatment tank;
incubating the biological liquid in the second treatment line for a predetermined time and adjusting the pH of the biological liquid by introducing a determined volume of acid and a determined volume of base into the second treatment line to approach a target pH;
transferring the treated biological liquid into the third main treatment tank also disposed at the fourth end of the second treatment line, and pre-polishing the treated biological fluid by introducing a determined volume of acid and a determined volume of base into the third main treatment tank to obtain a final treated biological liquid at the target pH; and
draining the third main treatment tank by regulating a draining rate of flow so as to provide a continuous rate of flow of treated biological liquid at the outlet from the installation at the same time as pre-polishing and/or of transferring and/or incubating and/or adjusting pH implemented in the second treatment line.