Patent ID: 11905531
Assignee: GENZYME CORPORATION
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 6:
7. A method of increasing the production of hyaluronic acid in chondrocytes and/or synoviocytes of a canine, comprising the steps of administering a rAAV to the canine, wherein the rAAV comprises a rAAV vector, wherein the rAAV vector comprises a DNA genome comprising nucleic acid encoding an HAS2 polypeptide operably linked to a promoter, wherein the rAAV comprises an AAV5 capsid, and wherein following administration the HAS2 polypeptide is expressed and catalyzes the production of additional hyaluronic acid, thereby increasing the level of hyaluronic acid (HA) in the canine, wherein the HAS2 polypeptide comprises the amino acid sequence set forth in SEQ ID NO:2.