Patent ID: 11884678
Assignee: DAIICHI SANKYO COMPANY, LIMITED
Field: Chemical engineering (Chemistry)
Classification: CPC C  B  Y | IPC B  C

Claim 1:
2. A method for producing a compound having formula (XXII):, , or a salt thereof, the method comprising:
reacting a compound of formula (XVI):, a compound of formula (XVII):, , and
a compound of formula (XVIII):, in a solvent in the presence of a Lewis acid which is Cu(OAc) or Cu(OAc)2 and a chiral ligand selected from:, to stereoselectively produce a compound represented by formula (XIX) or a salt thereof,, , hydrolyzing the compound of formula (XIX) to produce a compound of formula (XXI):, , and
condensing the compound of formula (XXI) with (1R,4R)-4-aminocyclohexane-1-carboxamide:, , to produce the compound of formula (XXII); wherein
M is N;
L is C(CH3)2; and
R53 is C1-C6 alkyl.