Patent ID: 11918650
Assignee: AMGEN INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 1:
2. The method of claim 1, wherein the bispecific antibody construct is present at a concentration in a range selected from the group consisting of:
(a) 0.5 to 200 μg/ml at a pH of 6.5 to 7.5,
(b) 0.5 to 1000 μg/ml at a pH of 4.0 to 6.0,
(c) 0.5 μg to 2 mg in the presence of a CD3 binding domain stabilizing agent, and
(d) 0.5 μg to 20 mg, at a pH of 4.0 to 7.5,
wherein the bispecific antibody comprises a third binding domain which comprises two polypeptide monomers, each comprising a hinge, a CH2 and a CH3 domain, wherein said two polypeptide monomers are fused to each other via a peptide linker, and wherein said third binding domain comprises in an amino to carboxyl order:
hinge-CH2-CH3-linker-hinge-CH2-CH3.