Patent ID: 11867627
Assignee: WASHINGTON UNIVERSITY
Field: Measurement (Instruments)
Classification: CPC G  A | IPC A  G

Claim 0:
1. A compact diffuse optical tomography (DOT) system for generating a functional image of a lesion region of a subject, comprising:
a source subsystem including:
a plurality of laser diodes configured to generate near-infrared (NIR) optical waves; and
a laser diode driver board configured to drive the plurality of laser diodes;

a probe configured to emit the optical waves generated by the source subsystem toward the lesion region and configured to detect optical waves reflected by the lesion region;
a detection subsystem including:
a miniaturized detection board including a photomultiplier tube (PMT), wherein the PMT has a plurality of channels and configured to convert the optical waves detected by the probe to electrical signals, and the miniaturized detection board further includes a combined board formed as one single board and including:
a frequency mixer configured to mix the electrical signals with reference signals to derive mixed signals;
a second-stage amplifier configured to amplify the mixed signals to derive amplified signals; and
a bandpass filter configured to filter the amplified signals to derive electrical signals of a selected frequency outputted by the miniaturized detection board; and

a miniaturized data acquisition board configured to convert the electrical signals outputted by the miniaturized detection board to digital signals, and to output the digital signals from the detection subsystem; and

a computing device separate from the source subsystem, the probe, and the detection subsystem, the computing device configured to:
receive the digital signals sent from the detection subsystem, the digital signals comprising lesion functional data from the lesion region of the subject and reference functional data from a healthy tissue region of the subject;
reconstruct the functional image of the lesion region based on the digital signals by:
transforming the lesion functional data and the reference functional data to produce perturbation data;
generating a preliminary estimate of the functional image by applying a truncated pseudoinverse matrix of a weight matrix to the perturbation data; and
generating the functional image by iteratively optimizing successive estimates of the functional image regularized by the preliminary estimate of the functional image weighted by a regularization parameter; and

display the functional image.