Patent ID: 11879143
Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
Field: Biotechnology (Chemistry)
Classification: CPC C | IPC C

Claim 0:
1. A method for producing a β-methyl-tryptophan or analog thereof, the method comprising:
(a) providing L-threonine, an indole or indole analog, and a polypeptide consisting of SEQ ID NOs: 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, or 38; and
(b) admixing the components of (a) in a reaction for a time and under conditions to produce a β-methyl-tryptophan or analog thereof,
wherein the indole analog is a compound according to Formula I:, , wherein
X1, X2, and X3 are independently carbon or nitrogen;
X4-X7 are carbon or nitrogen; and
R1-R7 are each independently selected from the group consisting of (i) H, —OH, an alkyl, an aryl, an alkoxy, an alkene, an alkyne, and substitutions of the foregoing, (ii) a sulfur-containing group, (iii) a nitrogen-containing group, (iv) an oxygen-containing group, and (v) a halogen.