Patent ID: 11952364
Assignee: TYLIGAND BIOSCIENCE (SHANGHAI) LIMITED
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A compound of formula I:, , wherein:
R1 is C1-6 alkyl or C3-6 cycloalkyl, optionally substituted by one or more halogens, —ORa, C1-6 alkyl or amino;
R5 is H, halogen, —ORa or optionally substituted C1-6 alkyl, and the substituent is selected from one or more halogen, —ORa, C1-6 alkyl or amino;
or R1 and R5 together with the atoms to which they are attached form a cyclic structure of the following formula:, where X is —CR7R8—, ═CR7—, —CR7R8—CR7R8— or —CR7═CR8—;
R6, R7, R8 and R9 are independently selected from H, halogen, —ORa, optionally substituted C1-6 alkyl or C3-6 cycloalkyl, wherein the substituent is selected from one or more halogens, —ORa, C1-6 alkyl or amino; or
R6 and R9 or R7 and R8 attached to the same carbon atom can form ═O or ═S together, or form a C3-6 cycloalkyl group together with the carbon atom to which they are attached;
R2 is C1-6 alkyl optionally substituted by one or more halogens, C1-6 alkyl, C1-6 alkoxy or amino; C3-6 cycloalkyl or C3-6 heterocyclic group, optionally substituted by one or more halogens, —ORa, C1-6 alkyl or amino; nitro, cyano, acyl, halogen, mercapto, C1-6 alkylthio, C1-6 alkylsulfonyl, C1-6 alkyl sulfinyl or carboxy;
R3 and R4 are each independently selected from H, halogen, nitro, cyano, acyl or carboxy;
Ra is selected from H or C1-6 alkyl;
provided that R1 and R2 are not methyl at the same time,
or isomers thereof, or their pharmaceutically acceptable salts or solvates.