Patent ID: 11910787
Assignee: REGENERON PHARMACEUTICALS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 15:
16. A rodent ES cell, comprising a replacement of a nucleotide sequence of an endogenous rodent Tmprss11d gene at an endogenous rodent Tmprss11d locus with a nucleotide sequence of a human TMPRSS11D gene to form a humanized Tmprss11d gene,
wherein the humanized Tmprss11d gene is under control of the promoter of the endogenous rodent Tmprss11d gene at the endogenous rodent Tmprss11d locus, and
wherein the humanized Tmprss11d gene encodes a humanized Tmprss11d protein that comprises (i) an ectodomain of the human TMPRSS11D protein encoded by the human TMPRSS11D gene, and (ii) a cytoplasmic and transmembrane portion encoded by the endogenous rodent Tmprss11d gene.