Patent ID: 11866421
Assignee: EPIGEN BIOSCIENCES, INC.
Field: Organic fine chemistry (Chemistry)
Classification: CPC C | IPC C

Claim 14:
15. The compound of claim 1 wherein the compound is selected from the group consisting of:
6-(1-Benzyl-1H-pyrazol-4-yl)-5-(p-chlorophenyl)-4-pyrimidinylamine,
5-(p-Chlorophenyl)-6-(1-methyl-1H-pyrazol-4-yl)-4-pyrimidinylamine,
5-(p-Chlorophenyl)-6-(1-{1-[m-(trifluoromethyl)phenyl]ethyl}-1H-pyrazol-4-yl)-4-pyrimidinylamine,
5-(p-Chlorophenyl)-6-(1-{[p-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)-4-pyrimidinylamine,
(R,S)-2-{4-[6-Amino-5-(p-chlorophenyl)-4-pyrimidinyl]-1H-pyrazol-1-yl}-2-phenylethanol,
(R,S)-6-[1-(2-Amino-1-phenylethyl)-1H-pyrazol-4-yl]-5-(p-chlorophenyl)-4-pyrimidinamine,
5-(p-Chlorophenyl)-6-[1-(1-phenylethenyl)-1H-pyrazol-4-yl]-4-pyrimidinylamine,
(R,S)-{4-[6-Amino-5-(p-chlorophenyl)-4-pyrimidinyl]-1H-pyrazol-1-yl}-phenylacetamide,
(R,S)—N,N-Dimethyl{4-[6-amino-5-(p-chlorophenyl)-4-pyrimidinyl]-1H-pyrazol-1-yl}phenylacetamide,
5-(p-Chlorophenyl)-6-(1-phenyl-1H-pyrazol-4-yl)-4-pyrimidinylamine,
5-(p-Chlorophenyl)-6-[1-(o-tolyl)-1H-pyrazol-4-yl]-4-pyrimidinylamine,
5-(p-Chlorophenyl)-6-[1-(m-chlorophenyl)-1H-pyrazol-4-yl]-4-pyrimidinylamine,
5-(p-Chlorophenyl)-6-{1-[m-(trifluoromethyl)phenyl]-1H-pyrazol-4-yl}-4-pyrimidinylamine,
5-(p-Chlorophenyl)-6-[1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl]-4-pyrimidinylamine,
5-(p-Chlorophenyl)-6-{1-[(m-fluorophenyl)methyl]-1H-pyrazol-4-yl}-4-pyrimidinylamine,
5-(p-Chlorophenyl)-6-{1-[(p-chlorophenyl)methyl]-1H-pyrazol-4-yl}-4-pyrimidinylamine,
5-(p-Chlorophenyl)-6-(1-{[o-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)-4-pyrimidinylamine,
5-(p-Chlorophenyl)-6-{1-[(p-fluorophenyl)methyl]-1H-pyrazol-4-yl}-4-pyrimidinylamine,
5-(p-Chlorophenyl)-6-{1-[(2,4-difluorophenyl)methyl]-1H-pyrazol-4-yl}-4-pyrimidinylamine,
5-(p-Chlorophenyl)-6-{1-[(p-trifluoromethoxyphenyl)methyl]-1H-pyrazol-4-yl}-4-pyrimidinylamine,
5-(p-Chlorophenyl)-6-{1-[(o-fluorophenyl)methyl]-1H-pyrazol-4-yl}-4-pyrimidinylamine,
{1-[6-Amino-5-(p-chlorophenyl)-4-pyrimidinyl]-1H-pyrazol-4-yl}phenylmethanone,
6-(4-Benzyl-1H-pyrazol-1-yl)-5-(p-chlorophenyl)-4-pyrimidinylamine,
5-(p-Methoxyphenyl)-6-(1-{[p-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)-4-pyrimidinylamine,
5-(p-Fluorophenyl)-6-(1-{[p-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)-4-pyrimidinylamine,
5-[p-(Methylsulfonyl)phenyl]-6-(1-{[p-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)-4-pyrimidinylamine,
5-(4-Chloro-3-fluorophenyl)-6-(1-{[p-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)-4-pyrimidinylamine,
5-(3,4-Dichlorophenyl)-6-(1-{[p-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)-4-pyrimidinylamine,
5-(4-Chloro-3-methoxyphenyl)-6-(1-{[p-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)-4-pyrimidinylamine,
5-(3-Chloro-4-methoxyphenyl)-6-(1-{[p-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)-4-pyrimidinylamine,
5-(3,4-Difluorophenyl)-6-(1-{[p-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)-4-pyrimidinylamine,
5-(3-Fluoro-4-methoxyphenyl)-6-(1-{[p-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)-4-pyrimidinylamine,
5-(4-Fluoro-3-methoxyphenyl)-6-(1-{[p-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)-4-pyrimidinylamine,
5-(p-Trifluoromethoxyphenyl)-6-(1-{[p-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)-4-pyrimidinylamine,
5-(2,2-Difluoro-2H-1,3-benzodioxol-5-yl)-6-(1-{[p-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)-4-pyrimidinylamine,
4-(1-{[p-(Trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)-2-pyridylamine,
5-Chloro-4-(1-{[p-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)-2-pyridylamine,
3-(p-Methoxyphenyl)-4-(1-{[p-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)-2-pyridylamine,
3-(p-Chlorophenyl)-4-(1-{[p-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)-2-pyridylamine,
5-(4-Chloro-3-fluorophenyl)-6-(1-{[p-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)-4-pyrimidinylamine,
5-(3-Fluoro-4-methoxyphenyl)-6-(1-{[p-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)-4-pyrimidinylamine,
5-(1H-Pyrazol-4-yl)-6-(1-{[p-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)-4-pyrimidinylamine,
N-[5-(p-Chlorophenyl)-6-(1-{[p-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)-4-pyrimidinyl]acetamide,
N-Acetyl-N-[5-(p-chlorophenyl)-6-(1-{[p-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)-4-pyrimidinyl]acetamide,
(Methylsulfonyl)[5-(p-chlorophenyl)-6-(1-{[p-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)-4-pyrimidinyl]amine,
N,N-Dimethyl[5-(p-chlorophenyl)-6-(1-{[p-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)-4-pyrimidinyl]amine,
N-Methyl[5-(p-chlorophenyl)-6-(1-{[p-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)-4-pyrimidinyl]amine,
6-(1-Benzyl-3-methyl-1H-pyrazol-4-yl)-5-(p-chlorophenyl)-4-pyrimidinylamine,
5-(p-Chlorophenyl)-6-(3-methyl-1-{[p-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)-4-pyrimidinylamine,
6-[1-(2-Amino-1-phenylethyl)-3-methyl-1H-pyrazol-4-yl]-5-(p-chlorophenyl)-4-pyrimidinamine,
6-(1-{2-Amino-1-[p-(trifluoromethyl)phenyl]ethyl}-3-methyl-1H-pyrazol-4-yl)-5-(p-chlorophenyl)-4-pyrimidinamine,
4-(1-Benzyl-3-methyl-1H-pyrazol-4-yl)-3-(p-chlorophenyl)-2-pyridylamine,
3-(p-Chlorophenyl)-4-(3-methyl-1-{[p-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)-2-pyridylamine,
4-[1-(2-Amino-1-phenylethyl)-3-methyl-H-pyrazol-4-yl]-3-(p-chlorophenyl)-2-pyridinamine,
4-(1-{2-Amino-1-[p-(trifluoromethyl)phenyl]ethyl}-3-methyl-1H-pyrazol-4-yl)-3-(p-chlorophenyl)-2-pyridinamine,
6-(1-Benzyl-3,5-dimethyl-1H-pyrazol-4-yl)-5-(p-chlorophenyl)-4-pyrimidinylamine,
5-(p-Chlorophenyl)-6-(3,5-dimethyl-1-{[p-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)-4-pyrimidinylamine,
6-[1-(2-Amino-1-phenylethyl)-3,5-dimethyl-1H-pyrazol-4-yl]-5-(p-chlorophenyl)-4-pyrimidinamine,
6-(1-{2-Amino-1-[p-(trifluoromethyl)phenyl]ethyl}-3,5-dimethyl-1H-pyrazol-4-yl)-5-(p-chlorophenyl)-4-pyrimidinamine,
4-(1-Benzyl-3,5-dimethyl-1H-pyrazol-4-yl)-3-(p-chlorophenyl)-2-pyridylamine,
3-(p-Chlorophenyl)-4-(3,5-dimethyl-1-{[p-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)-2-pyridylamine,
4-[1-(2-Amino-1-phenylethyl)-3,5-dimethyl-1H-pyrazol-4-yl]-3-(p-chlorophenyl)-2-pyridinamine,
4-(1-{2-Amino-1-[p-(trifluoromethyl)phenyl]ethyl}-3,5-dimethyl-1H-pyrazol-4-yl)-3-(p-chlorophenyl)-2-pyridinamine,
{4-[6-Amino-5-(p-chlorophenyl)-4-pyrimidinyl]-1-benzyl-1H-pyrazol-3-yl}methanol,
{4-[6-Amino-5-(p-chlorophenyl)-4-pyrimidinyl]-1-{[p-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-3-yl}methanol,
{4-[6-Amino-5-(p-chlorophenyl)-4-pyrimidinyl]-1-(2-amino-1-phenylethyl)-1H-pyrazol-3-yl}methanol,
{4-[6-Amino-5-(p-chlorophenyl)-4-pyrimidinyl]-1-{2-amino-1-[p-(trifluoromethyl)-phenyl]ethyl}-1H-pyrazol-3-yl}methanol,
{4-[2-Amino-3-(p-chlorophenyl)-4-pyridyl]-1-benzyl-1H-pyrazol-3-yl}methanol,
{4-[2-Amino-3-(p-chlorophenyl)-4-pyridyl]-1-{[p-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-3-yl}methanol,
{4-[2-Amino-3-(p-chlorophenyl)-4-pyridyl]-1-(2-amino-1-phenylethyl)-1H-pyrazol-3-yl}methanol,
{4-[2-Amino-3-(p-chlorophenyl)-4-pyridyl]-1-{2-amino-1-[p-(trifluoromethyl)phenyl]-ethyl}-1H-pyrazol-3-yl}methanol,
6-(1-Benzyl-3-fluoro-1H-pyrazol-4-yl)-5-(p-chlorophenyl)-4-pyrimidinylamine,
5-(p-Chlorophenyl)-6-(3-fluoro-1-{[p-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)-4-pyrimidinylamine,
6-[1-(2-Amino-1-phenylethyl)-3-fluoro-1H-pyrazol-4-yl]-5-(p-chlorophenyl)-4-pyrimidinamine,
6-(1-{2-Amino-1-[p-(trifluoromethyl)phenyl]ethyl}-3-fluoro-1H-pyrazol-4-yl)-5-(p-chlorophenyl)-4-pyrimidinamine,
4-(1-Benzyl-3-fluoro-1H-pyrazol-4-yl)-3-(p-chlorophenyl)-2-pyridylamine,
3-(p-Chlorophenyl)-4-(3-fluoro-1-{[p-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)-2-pyridylamine,
4-[1-(2-Amino-1-phenylethyl)-3-fluoro-1H-pyrazol-4-yl]-3-(p-chlorophenyl)-2-pyridinamine,
4-(1-{2-Amino-1-[p-(trifluoromethyl)phenyl]ethyl}-3-fluoro-1H-pyrazol-4-yl)-3-(p-chlorophenyl)-2-pyridinamine,
6-[1-Benzyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-5-(p-chlorophenyl)-4-pyrimidinylamine,
5-(p-Chlorophenyl)-6-[3-(trifluoromethyl)-1-{[p-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl]-4-pyrimidinylamine,
6-[1-(2-Amino-1-phenylethyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl]-5-(p-chlorophenyl)-4-pyrimidinamine,
6-(1-{2-Amino-1-[p-(trifluoromethyl)phenyl]ethyl}-3-(trifluoromethyl)-1H-pyrazol-4-yl)-5-(p-chlorophenyl)-4-pyrimidinamine,
4-[1-Benzyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-3-(p-chlorophenyl)-2-pyridylamine,
3-(p-Chlorophenyl)-4-[3-(trifluoromethyl)-1-{[p-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl]-2-pyridylamine,
4-[1-(2-Amino-1-phenylethyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl]-3-(p-chlorophenyl)-2-pyridinamine,
4-(1-{2-Amino-1-[p-(trifluoromethyl)phenyl]ethyl}-3-(trifluoromethyl)-1H-pyrazol-4-yl)-3-(p-chlorophenyl)-2-pyridinamine,
(2S)-2-{4-[6-Amino-5-(p-chlorophenyl)-4-pyrimidinyl]-1H-pyrazol-1-yl}-2-phenylethanol,
(2R)-2-{4-[6-Amino-5-(p-chlorophenyl)-4-pyrimidinyl]-1H-pyrazol-1-yl}-2-phenylethanol,
(2S)-2-{4-[6-Amino-5-(p-chlorophenyl)-4-pyrimidinyl]-1H-pyrazol-1-yl}-2-[p-(trifluoromethyl)phenyl]ethanol,
(2R)-2-{4-[6-Amino-5-(p-chlorophenyl)-4-pyrimidinyl]-1H-pyrazol-1-yl}-2-[p-(trifluoromethyl)phenyl]ethanol,
(2S)-2-{4-[6-Amino-5-(p-chlorophenyl)-4-pyrimidinyl]-1H-pyrazol-1-yl}-2-phenylethanamine,
(2R)-2-{4-[6-Amino-5-(p-chlorophenyl)-4-pyrimidinyl]-1H-pyrazol-1-yl}-2-phenylethanamine,
(2S)-2-{4-[6-Amino-5-(p-chlorophenyl)-4-pyrimidinyl]-1H-pyrazol-1-yl}-2-[p-(trifluoromethyl)phenyl]ethanamine,
(2R)-2-{4-[6-Amino-5-(p-chlorophenyl)-4-pyrimidinyl]-1H-pyrazol-1-yl}-2-[p-(trifluoromethyl)phenyl]ethanamine,
(2S)-2-{4-[6-Amino-5-(p-chlorophenyl)-4-pyrimidinyl]-1H-pyrazol-1-yl}-1-(dimethylamino)-2-phenylethane,
(2R)-2-{4-[6-Amino-5-(p-chlorophenyl)-4-pyrimidinyl]-1H-pyrazol-1-yl}-1-(dimethylamino)-2-phenylethane,
(2S)-2-{4-[6-Amino-5-(p-chlorophenyl)-4-pyrimidinyl]-1H-pyrazol-1-yl}-1-(dimethylamino)-2-[p-(trifluoromethyl)phenyl]ethane,
(2R)-2-{4-[6-Amino-5-(p-chlorophenyl)-4-pyrimidinyl]-1H-pyrazol-1-yl}-1-(dimethylamino)-2-[p-(trifluoromethyl)phenyl]ethane,
(2S)-2-{4-[6-Amino-5-(1H-pyrazol-4-yl)-4-pyrimidinyl]-1H-pyrazol-1-yl}-1-(dimethylamino)-2-[p-(trifluoromethyl)phenyl]ethane,
(R)-2-{4-[6-Amino-5-(1H-pyrazol-4-yl)-4-pyrimidinyl]-1H-pyrazol-1-yl}-1-(dimethylamino)-2-[p-(trifluoromethyl)phenyl]ethane,
(2S)-{4-[6-Amino-5-(p-chlorophenyl)-4-pyrimidinyl]-1H-pyrazol-1-yl}[p-(trifluoromethyl)phenyl]acetic acid,
(2R)-{4-[6-Amino-5-(p-chlorophenyl)-4-pyrimidinyl]-1H-pyrazol-1-yl}[p-(trifluoromethyl)phenyl]acetic acid,
(2S)-{4-[6-Amino-5-(p-chlorophenyl)-4-pyrimidinyl]-1H-pyrazol-1-yl}[p-(trifluoromethyl)phenyl]acetamide,
(2R)-{4-[6-Amino-5-(p-chlorophenyl)-4-pyrimidinyl]-1H-pyrazol-1-yl}[p-(trifluoromethyl)phenyl]acetamide,
3-(1H-Pyrazol-4-yl)-4-(1-{[p-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)-2-pyridylamine,
(S)-2-{4-[2-Amino-3-(p-chlorophenyl)-4-pyridyl]-1H-pyrazol-1-yl}-2-[p-(trifluoromethyl)phenyl]ethanol,
(R)-2-{4-[2-Amino-3-(p-chlorophenyl)-4-pyridyl]-1H-pyrazol-1-yl}-2-[p-(trifluoromethyl)phenyl]ethanol,
4-(1-{(S)-2-Amino-1-[p-(trifluoromethyl)phenyl]ethyl}-1H-pyrazol-4-yl)-3-(p-chlorophenyl)-2-pyridinamine,
4-(1-{(R)-2-Amino-1-[p-(trifluoromethyl)phenyl]ethyl}-1H-pyrazol-4-yl)-3-(p-chlorophenyl)-2-pyridinamine,
4-(1-{(S)-2-(Dimethylamino)-1-[p-(trifluoromethyl)phenyl]ethyl}-1H-pyrazol-4-yl)-3-(p-chlorophenyl)-2-pyridinamine,
4-(1-{(R)-2-(Dimethylamino)-1-[p-(trifluoromethyl)phenyl]ethyl}-1H-pyrazol-4-yl)-3-(p-chlorophenyl)-2-pyridinamine,
(S)-{4-[2-Amino-3-(p-chlorophenyl)-4-pyridyl]-1H-pyrazol-1-yl}[p-(trifluoromethyl)phenyl]acetic acid,
(R)-{4-[2-Amino-3-(p-chlorophenyl)-4-pyridyl]-1H-pyrazol-1-yl}[p-(trifluoromethyl)phenyl]acetic acid,
(S)-{4-[2-Amino-3-(p-chlorophenyl)-4-pyridyl]-1H-pyrazol-1-yl}[p-(trifluoromethyl)phenyl]acetamide,
(R)-{4-[2-Amino-3-(p-chlorophenyl)-4-pyridyl]-1H-pyrazol-1-yl}[p-(trifluoromethyl)phenyl]acetamide,
and salts thereof.