Patent ID: 11931423
Assignee: UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 0:
1. A bioconjugate comprising:
(a) a superparamagnetic iron oxide nanoparticle functionalized with a first bioorthogonal ligation moiety selected from the group consisting of tetrazine, an azide, a tetrazole, and combinations thereof, wherein the nanoparticle has a diameter of about 4 nm to about 8 nm; and
(b) a glucose oxidase conjugated to the superparamagnetic iron oxide nanoparticle, wherein the glucose oxidase is functionalized with a second bioorthogonal ligation moiety selected from the group consisting of trans-cyclooctene, cyclooctyne, an alkyne, an alkene, photo-DIBO, cyclopropenone, and combinations thereof.