Patent ID: 11912766
Assignee: ALLAKOS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC C

Claim 0:
1. An anti-Siglec-7 antibody that binds to Siglec-7;
wherein the anti-Siglec-7 antibody comprises a variant Fc region that comprises at least one amino acid amino acid modification that reduces effector function or increases antibody stability compared to the corresponding native Fc region, and wherein the antibody comprises:
(a) a heavy chain variable region comprising the amino acid sequence of SEQ ID NO:55 and a light chain variable region comprising the amino acid sequence of SEQ ID NO:69;
(b) a heavy chain variable region comprising the amino acid sequence of SEQ ID NO:57 and a light chain variable region comprising the amino acid sequence of SEQ ID NO:69; or
(c) a heavy chain variable region comprising the amino acid sequence of SEQ ID NO:59 and a light chain variable region comprising the amino acid sequence of SEQ ID NO:78.