Patent ID: 11897954
Assignee: ASTELLAS PHARMA INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A bispecific antibody that binds to TSPAN8 and CD3, comprising:
(a) a Fab region of an anti-TSPAN8 antibody consisting of: a heavy chain fragment comprising a heavy chain variable region of the anti-TSPAN8 antibody; and a light chain comprising a light chain variable region of the anti-TSPAN8 antibody;
(b) an anti-CD3-scFv region comprising a heavy chain variable region and a light chain variable region of an anti-CD3 antibody; and
(c) a Fc region consisting of a first Fc polypeptide linked to the heavy chain fragment of the Fab region (a) and a second Fc polypeptide linked to the anti-CD3-scFv region (b),
wherein
the heavy chain variable region of the anti-TSPAN8 antibody comprises a CDR1 consisting amino acids 31 to 35 of SEQ ID NO: 6, a CDR2 consisting of amino acids 50 to 66 of SEQ ID NO: 6, and a CDR3 consisting of amino acids 99 to 110 of SEQ ID NO: 6, and the light chain variable region of the anti-TSPAN8 antibody comprises a CDR1 consisting of amino acids 24 to 34 of SEQ ID NO: 8, a CDR2 consisting of amino acids 50 to 56 of SEQ ID NO: 8, and a CDR3 consisting of amino acids 89 to 96 of SEQ ID NO: 8; or
the heavy chain variable region of the anti-TSPAN8 antibody comprises a CDR1 consisting of amino acids 31 to 35 of SEQ ID NO: 10, a CDR2 consisting of amino acids 50 to 66 of SEQ ID NO: 10, and a CDR3 consisting of amino acids 99 to 110 of SEQ ID NO: 10, and the light chain variable region of the anti-TSPAN8 antibody comprises a CDR1 consisting of amino acids 24 to 34 of SEQ ID NO: 12, a CDR2 consisting of amino acids 50 to 56 of SEQ ID NO: 12, and a CDR3 consisting of amino acids 89 to 96 of SEQ ID NO: 12.