Patent ID: 11905229
Assignee: FUDAN UNIVERSITY
Field: Organic fine chemistry (Chemistry)
Classification: CPC C  B  Y | IPC B  C

Claim 4:
5. The method of claim 1, wherein in step (S3), the basic catalyst is an inorganic base or an organic base; the inorganic base is selected from the group consisting of sodium hydroxide, calcium hydroxide, sodium carbonate, sodium bicarbonate, potassium carbonate, potassium bicarbonate and sodium hydride; and the organic base is selected from the group consisting of triethylamine, pyridine, sodium methoxide, lithium diisopropylamide and 1,8-diazabicyclo[5.4.0]undec-7-ene;
a molar ratio of 2-(2,6-dichlorophenoxy)-N-phenylacetamide (III) to the basic catalyst is 1:(0.001-20);
the Smiles rearrangement is performed in an organic solvent selected from the group consisting of N,N-dimethylformamide, dimethyl sulfoxide, methanol, ethanol, toluene, acetonitrile, ethyl acetate and acetone; and
the Smiles rearrangement is performed at 0-100° C. for 0.5-10 h.