Patent ID: 11925689
Assignee: SERINA THERAPEUTICS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 9:
10. A heterofunctional polyoxazoline derivative of the general structure:

R1—{[N(COX)CH2CH2]o—[N(COR2)CH2—CH2)]n—[N(COY)CH2—CH2)]m}a—S—U—W

wherein:
R1 is an initiating group;
R2 is independently selected for each repeating unit from an unsubstituted or substituted alkyl, an unsubstituted or substituted alkenyl, an unsubstituted or substituted aralkyl or an unsubstituted or substituted heterocyclylalkyl group;
X is a pendent moiety containing a first functional group and the first functional group is selected from the group consisting of: an alkyne, an amine, an oxyamine, an aldehyde, a ketone, an acetal, a ketal, an ester, a carboxylic acid, an activated carboxylic acid, an active carbonate, a chloroformate, an alcohol, an azide, a vinyl sulfone, a maleimide and orthopyridyl disulfide;
Y is a pendent moiety containing a second functional group and the second functional group is selected from the group consisting of: an alkyne, an amine, an oxyamine, an aldehyde, a ketone, an acetal, a ketal, an ester, a carboxylic acid, an activated carboxylic acid, an active carbonate, a chloroformate, an alcohol, an azide, a vinyl sulfone, a maleimide and orthopyridyl disulfide;
U is a linking group;
W is a third functional group;
a is ran which indicates a random copolymer or block which indicates a block copolymer;
o and m are each an integer independently selected from 1-50; and
n is an integer selected from 0-1000;, wherein the heterofunctional polyoxazoline derivative is linked to at least one target molecule, through at least one of the first or second functional groups.