Patent ID: 11879001
Assignee: ASCENDIS PHARMA ONCOLOGY DIVISION A/S
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 12:
13. A conjugate or pharmaceutically acceptable salt thereof comprising an IL-2 moiety of SEQ ID NO:14, to which a moiety Mmod of formula (A-1a), is conjugated to the sulfur of the cysteine at position 38, wherein the dashed line marked with the asterisk indicates attachment to the sulfur and b1 is 2, b2 is 2 or 3 and b3 is an integer wherein the molecular weight of Mmod is 5±25% kDa, the conjugation to Mmod being stable, and to which IL-2 moiety a moiety of formula (XI-a), is conjugated to the nitrogen of a primary amine of the N-terminus or a lysine side chain residue of the IL-2 moiety; wherein the dashed line indicates attachment to the nitrogen and p1, p2, p3 and p4 are independently of each other an integer ranging from 185 to 450, the conjugation to the moiety of formula (XI-a) being reversible.