Patent ID: 11896382
Assignee: RETISPEC INC.
Field: Measurement (Instruments)
Classification: CPC A  G | IPC A  G

Claim 0:
1. A non-invasive in vivo ocular light-based detection system comprising:
a fundus camera, comprising:
a spectral reflectance imaging unit that includes a broadband light source and a light sensor; and
a lens assembly configured to focus light from the broadband light source onto a fundus of an eye of a subject; and

one or more processors configured to execute instructions stored in a memory to:
control the spectral reflectance imaging unit to illuminate the fundus of the eye using the broadband light source, and detect resulting reflected and/or backscattered light from the eye using the light sensor for determining spectral reflectance information;
generate a plurality of spectral reflectance maps, wherein each of the plurality of spectral reflectance maps comprise counts of reflected and/or backscattered light at a different wavelength or a different range of wavelengths;
assign a weight to each of the plurality of spectral reflectance maps;
determine one or more region of interest (ROI) from the weighted spectral reflectance maps as being a potential Alzheimer's Disease (AD)-associated pathology based on a detection of one or more biomarkers indicative of Tauopathy; and
classify, using the spectral reflectance information, the subject as having one or more AD-associated pathologies, the one or more AD-associated pathologies associated with the one or more biomarkers indicative of Tauopathy, wherein the one or more biomarkers indicative of Tauopathy comprise Tau neurofibrillary tangles.