Patent ID: 11912975
Assignee: MIRAI MEDICAL LIMITED
Field: Medical technology (Instruments)
Classification: CPC C  A | IPC A  C

Claim 21:
22. A method of operation of an electroporation apparatus comprising:
a plurality of electroporation probe terminals;
a transformer for providing stepped-up voltage,
a switching circuit with switches for linking high voltage and low voltage or ground levels to the probe terminals; and
a controller configured to control said switches according to a control scheme to deliver pulses to the probe terminals, and in which said pulses are delivered to groups of at least two probe electrode terminals for probe electrodes which are spaced apart, and
a plurality of probe electrodes connected to said probe terminals; and the probe electrodes are in a probe head comprising at least one hollow electrode needle which is hollow and has at least one opening,, the method comprising:
inserting said probe electrodes into a biological load,
the controller applying bi-polar voltage pulses into the electrodes and the load for electroporation, in which the controller applies a ramp-up (tr) duration of less than 0.5 μs to a plateau amplitude in the range of 100V to 3000V for a duration in the range of 1 μs to 5 μs, and a ramp-down (tf) duration from said voltage of less than 0.5 μs for each probe electrode terminal, and
causing flow of a substance into tissue via said needle and said opening, wherein the controller controls flow of said substance to the one or more hollow needles while driving said needle or needles with said pulses.