Patent ID: 11919908
Assignee: INCYTE CORPORATION
Field: Organic fine chemistry (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 27:
28. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein:
n is 1 or 2;
each R1 is independently selected from phenyl-C1-6 alkyl-, C3-6 cycloalkyl-C1-6 alkyl-, (5-6 membered heteroaryl)-C1-2 alkyl-, (4-6 membered heterocycloalkyl)-C1-2 alkyl-, C(O)Rb1, C(O)NRc1Rd1, C(O)ORa1, S(O)Rb1, S(O)NRc1Rd1, S(O)2Rz1, and S(O)2NRc1Rd1, wherein the phenyl-C1-6 alkyl-, C3-6 cycloalkyl-C1-6 alkyl-, (5-6 membered heteroaryl)-C1-2 alkyl-, and (4-6 membered heterocycloalkyl)-C1-2 alkyl- of R1 are each optionally substituted with 1, 2, 3, or 4 independently selected R1A substituents;
each Rc1 and Rd1 is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, and C2-6 alkynyl;
or, any Rc1 and Rd1 attached to the same N atom, together with the N atom to which they are attached, form a 5-6 membered heteroaryl or a 4-6 membered heterocycloalkyl group, wherein the 5-6 membered heteroaryl or 4-6 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected R1A substituents;
each Rb1 is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, and C2-6 alkynyl;
each Rz1 is independently selected from H, C2-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, and C2-6 alkynyl;
each R1A is independently selected from S(O)Rb11, S(O)NRc11Rd11, S(O)2Rb11, and S(O)2NRc11Rd11;
each Rb11, Rc11, and Rd11 is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, and C2-6 alkynyl;
R2 is selected from C2-6 alkyl, C6-10 aryl, C3-10 cycloalkyl, 5-membered heteroaryl, 7-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10 aryl-C1-6 alkyl-, C3-10 cycloalkyl-C1-6 alkyl-, (5-10 membered heteroaryl)-C1-6 alkyl-, and (4-10 membered heterocycloalkyl)-C1-6 alkyl-, wherein the C2-6 alkyl, C6-10 aryl, C3-10 cycloalkyl, 5-membered heteroaryl, 7-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10 aryl-C1-6 alkyl-, C3-10 cycloalkyl-C1-6 alkyl-, (5-10 membered heteroaryl)-C1-6 alkyl-, and (4-10 membered heterocycloalkyl)-C1-6 alkyl- of R2 are each optionally substituted with 1, 2, 3, or 4 independently selected R2A substituents;
each R2A is independently selected from halo, C1-6 alkyl, C1-6 haloalkyl, C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10 aryl-C1-6 alkyl-, C3-10 cycloalkyl-C1-6 alkyl-, (5-10 membered heteroaryl)-C1-6 alkyl-, (4-10 membered heterocycloalkyl)-C1-6 alkyl-, CN, ORa21, C(O)NRc21Rd21, C(O)ORa21, S(O)Rb21, S(O)NRc21Rd21, S(O)2Rb21, and S(O)2NRc21Rd21, wherein the C1-6 alkyl, C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10 aryl-C1-6 alkyl-, C3-10 cycloalkyl-C1-6 alkyl-, (5-10 membered heteroaryl)-C1-6 alkyl-, and (4-10 membered heterocycloalkyl)-C1-6 alkyl- of R2A are each optionally substituted with 1, 2, 3, or 4 independently selected R2B substituents;
each Ra21, Rb21, Rc21, and Rd21 is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, and C2-6 alkynyl;
each R2B is independently selected from oxo, C1-6 alkyl, CN, ORa22, C(O)ORa22, and NRc22Rd22; and
each Ra22, Rc22, and Rd22 is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, and C2-6 alkynyl.