Patent ID: 11899025
Assignee: KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
Field: Measurement (Instruments)
Classification: CPC G  A  C | IPC A  G

Claim 0:
1. A method of screening an agent for treating Alzheimer's disease, the method comprising the following steps of:
(a) treating cells expressing SphK1 (sphingosine kinase 1) mRNA or protein with a test substance;
(b) measuring the expression level of the SphK1 mRNA or protein in the cells treated with the test substance and cells not treated with the test substance;
(c) selecting a substance that has increased the expression level of the SphK1 mRNA or protein compared to the cells not treated with the test substance;
(d) treating cells expressing COX2 (cyclooxygenase-2) protein with the test substance selected in the step (c);
(e) measuring the degree of acetylation of the COX2 in the cells treated with the test substance and the cells not treated with the test substance; and
(f) selecting a substance having an increased degree of acetylation of the COX2 protein as compared to cells not treated with the test substance as an agent for treating Alzheimer's disease.