Patent ID: 11890377
Assignee: TRANSLATE BIO, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 0:
1. A method of delivery of messenger RNA (mRNA) in vivo, comprising administering to a subject in need of delivery a composition comprising an mRNA that encodes Factor IX (FIX), wherein said mRNA is encapsulated within a liposome such that the administering of the composition results in the expression of the protein encoded by the mRNA in vivo; and
wherein the liposome comprises a cationic lipid of formula I-g:, or a pharmaceutically acceptable salt thereof,
wherein:
RL is C1-50 alkyl, C2-50 alkenyl, or C2-50 alkynyl, and
wherein the mRNA has a length of or greater than about 0.5 kb.