Patent ID: 11911487
Assignee: THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 0:
1. A method to treat a mammalian subject having an acute kidney injury, the method comprising:
occluding the renal vein to the kidney having the acute injury;
administering a retrograde hydrodynamic injection of a therapeutically effective amount of a fluid consisting of an isotonic saline solution into the occluded renal vein of the subject at a site between the occlusion and the kidney such that the renal venous pressure is increased during the injection;
waiting, after the retrograde hydrodynamic injection, for a decrease in the renal venous pressure before unoccluding the renal vein;
unoccluding the renal vein; and,
measuring the serum creatinine level from a biological sample from the mammalian subject where the biological sample is obtained from the mammalian subject after the retrograde hydrodynamic injection is administered and where the serum creatinine level of the mammalian subject is reduced to the normal, baseline level after the injection is administered.