Patent ID: 11897960
Assignee: BEIJING WISDOMAB BIOTECHNOLOGY CO., LTD
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. An antibody that binds to human IL-4R comprising a heavy chain variable region comprising HCDR1, HCDR2 and HCDR3 and a light chain variable region comprising LCDR1, LCDR2 and LCDR, wherein
the HCDR1 has the sequence of GFTFSSYAMS (SEQ ID NO: 33), the HCDR2 has the sequence of SITGGGGGIYYADSVKG (SEQ ID NO: 34), the HCDR3 has the sequence of DRISITIRPRYFGLDF (SEQ ID NO: 35), the LCDR1 has the sequence of RSSQSLLYSIGYNYLD (SEQ ID NO: 36), the LCDR2 has the sequence of LGSNRAS (SEQ ID NO: 37), and the LCDR3 has the sequence of MQSFKAPYT (SEQ ID NO: 38); or
the HCDR1 has the sequence of GFTFSSYAMS (SEQ ID NO: 33), the HCDR2 has the sequence of SITGGGGGIYYADSVKG (SEQ ID NO: 34), the HCDR3 has the sequence of DRISITIRPRYFGLDF (SEQ ID NO: 35), the LCDR1 has the sequence of RSSRNVIYGNGYNYLD (SEQ ID NO: 39), the LCDR2 has the sequence of LGNNVAA (SEQ ID NO: 40), and the LCDR3 has the sequence of MQSLQAPYT (SEQ ID NO: 41); or
the HCDR1 has the sequence of GFTFSSYAMS (SEQ ID NO: 33), the HCDR2 has the sequence of SITGGGGGIYYADSVKG (SEQ ID NO: 34), the HCDR3 has the sequence of DRISITIRPRYFGLDF (SEQ ID NO: 35), the LCDR1 has the sequence of RSSQNVYGNGYNYLD (SEQ ID NO: 42), the LCDR2 has the sequence of LGTNVAA (SEQ ID NO: 43), and the LCDR3 has the sequence of MQSLQAPYT (SEQ ID NO: 41); or
the HCDR1 has the sequence of GFTFSSYAMS (SEQ ID NO: 33), the HCDR2 has the sequence of SITGGGGGIYYADSVKG (SEQ ID NO: 34), the HCDR3 has the sequence of DRISITIRPRYFGLDF (SEQ ID NO: 35), the LCDR1 has the sequence of RSSQNVYGNGYNYLD (SEQ ID NO: 42), the LCDR2 has the sequence of LGNNVAA (SEQ ID NO: 40), and the LCDR3 has the sequence of MQSLKAPYT (SEQ ID NO: 44); or
the HCDR1 has the sequence of GFTFSSYAMS (SEQ ID NO: 33), the HCDR2 has the sequence of SITGGGGGIYYADSVKG (SEQ ID NO: 34), the HCDR3 has the sequence of DRISITIRPRYFGLDF (SEQ ID NO: 35), the LCDR1 has the sequence of RSSHNLLYSNGYNYLD (SEQ ID NO: 45), the LCDR2 has the sequence of LGSNRAY (SEQ ID NO: 46), and the LCDR3 has the sequence of MQALQSPYT (SEQ ID NO: 47);
the HCDR1 has the sequence of GFTFSSYAMS (SEQ ID NO: 33), the HCDR2 has the sequence of SITGGGGGIYYADSVKG (SEQ ID NO: 34), the HCDR3 has the sequence of DRISITIRPRYFGLDF (SEQ ID NO: 35), the LCDR1 has the sequence of RSSQSLLYSNGYNYLD (SEQ ID NO: 48), the LCDR2 has the sequence of LGSNRAS (SEQ ID NO: 37), and the LCDR3 has the sequence of MQALETPYA (SEQ ID NO: 49);
wherein the HCDR and LCDR are defined according to Kabat.