Patent ID: 11903638
Assignee: BIOSENSE WEBSTER (ISRAEL) LTD.
Field: Medical technology (Instruments)
Classification: CPC A | IPC A

Claim 14:
15. A computer-implemented method for regulating delivery of irreversible electroporation (IRE) pulses during ablation, the method comprising:
determining, based on IRE setup parameters, a target value of dissipated electrical energy to be transferred to tissue within a body of a patient from bipolar trains of pulses applied to the tissue in contact with at least one pair of electrodes of a probe, each bipolar pulse having a voltage amplitude of at least 200 V and a duration less than 20 μs between the at least one pair of electrodes;
causing electrical and temporal parameters of the bipolar trains of pulses to be transmitted to an electrical signal generator;
measuring a dissipated electrical energy between the at least one pair of the electrodes from the bipolar trains of pulses, which is to be transferred to the tissue during the bipolar trains of the pulses, by computing a sum of a product of a voltage and a current flowing between the at least one pair of electrodes over a sequence of time intervals, the voltage and current being measured by one or more electrical sensors coupled to an output of the electrical signal generator;
determining, continuously, whether the measured dissipated electrical energy that is to be transferred to the tissue in contact with the least one pair of electrodes during IRE is equal to or exceeds the target value;
causing the IRE to be terminated when the measured dissipated electrical energy that is to be transferred to the tissue is equal to or exceeds the target value;
determining, when the measured dissipated energy that is to be transferred to the tissue is less than the target value, a predicted total dissipated electrical energy to be transferred to the tissue based upon the electrical and temporal parameters;
comparing the predicted total dissipated electrical energy to the target value;
causing the electrical and temporal parameters to be modified when the predicted total dissipated energy is less than the target value; and
causing the IRE to be terminated when the measured dissipated electrical energy that is to be transferred to the tissue equals the target value.