Patent ID: 11874285
Assignee: RADIOMETER MEDICAL APS
Field: Measurement (Instruments)
Classification: CPC G  C | IPC C  G

Claim 0:
1. A method for recalibrating the sensitivity of one or more sensors in a measuring device for measuring concentration of creatinine (Crn) using one or more calibration solutions, wherein the method comprises:
providing the measuring device for determining concentration of Crn in a solution, wherein the measuring device comprises the one or more sensors having the sensitivity in need of recalibration;
providing the one or more calibration solutions comprising one or more of a creatine (Cr) calibration solution and/or one or more of a Crn calibration solution for the one or more sensors, wherein the one or more calibration solutions has been stored at at least one unknown temperature after an initial time;
receiving concentrations at the initial time of Cr and/or Crn in the one or more calibration solutions;
receiving outputs of the measuring device at an end time;
calculating concentration of Cr and/or Crn in the one or more calibration solutions at the end time using a two-temperature temperature model, rate equations for an equilibrium reaction of Cr and Crn, and the Arrhenius equation;
wherein the two-temperature temperature model indicates an estimation of temperature of the one or more calibration solutions from the initial time to the end time, and wherein the two-temperature temperature model includes a variable parameter, and
wherein the two-temperature temperature model is determined by at least calculating the variable parameter,
wherein said calculating the variable parameter comprises solving an analytic expression comprising the rate equations for the equilibrium reaction of Cr and Crn, the two-temperature temperature model, and the outputs of the measuring device;

determining the sensitivity of the one or more sensors based on a relationship between the outputs of the measuring device and the calculated concentration of Cr and/or Crn; and
recalibrating the sensitivity of the one or more sensors for subsequent determination of the concentration of Cr and/or Crn in a sample.