Patent ID: 11919900
Assignee: KING FAISAL UNIVERSITY
Field: Organic fine chemistry (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 13:
14. A method of treating tuberculosis selected from the group consisting of multi drug resistant (MDR) strains of Mycobacterium tuberculosis, extensively drug resistant (XDR) strains of Mycobacterium tuberculosis, H37Rv strains of Mycobacterium tuberculosis, and a combination thereof in a patient, comprising administering to a patient in need thereof a therapeutically effective amount of a compound selected from the group consisting of:
Dimethyl 4-bromo-1-(4-methoxybenzoyl)pyrrolo[1,2-a]quinoline-2,3-dicarboxylate (QUIN-KNV1);
Ethyl 4-bromo-1-(4-methoxybenzoyl)pyrrolo[1,2-a]quinoline-3-carboxylate (QUIN-KNV2);
Dimethyl 4-bromo-1-(4-chlorobenzoyl)pyrrolo[1,2-a]quinoline-2,3-dicarboxylate (QUIN-KNV3);
Ethyl 4-bromo-1-(4-chlorobenzoyl)pyrrolo[1,2-a]quinoline-3-carboxylate (QUIN-KNV4);
Dimethyl 4-bromo-1-(4-bromobenzoyl)pyrrolo[1,2-a]quinoline-2,3-dicarboxylate (QUIN-KNV5);
Ethyl 4-bromo-1-(4-bromobenzoyl)pyrrolo[1,2-a]quinoline-3-carboxylate (QUIN-KNV6);
Dimethyl 4-bromo-1-(4-fluorobenzoyl)pyrrolo[1,2-a]quinoline-2,3-dicarboxylate (QUIN-KNV7);
Ethyl 4-bromo-1-(4-fluorobenzoyl)pyrrolo[1,2-a]quinoline-3-carboxylate (QUIN-KNV8);
Dimethyl 4-bromo-1-(4-cyanobenzoyl)pyrrolo[1,2-a]quinoline-2,3-dicarboxylate (QUIN-KNV9);
Ethyl 4-bromo-1-(4-cyanobenzoyl)pyrrolo[1,2-a]quinoline-3-carboxylate (QUIN-KNV10);
Dimethyl 1-benzoyl-4-bromopyrrolo[1,2-a]quinoline-2,3-dicarboxylate (QUIN-KNV11);
Ethyl 4-bromo-1-(2-nitrobenzoyl)pyrrolo[1,2-a]quinoline-3-carboxylate (QUIN-KNV12);
and a pharmaceutically acceptable salt, ester, stereoisomer, or solvate thereof.