Patent ID: 11866497
Assignee: THE UNIVERSITY OF TOKYO
Field: Measurement (Instruments)
Classification: CPC C  A  G | IPC A  C  G

Claim 4:
5. The method of claim 2, further comprising administering to the subject an antibody or an antigen-binding fragment thereof that binds to secreted CHL1 protein and can neutralizes the binding of the secreted CHL1 protein to a non-immune and non-epithelial non-hemocyte cell of the lamina propria and a submucosal layer,
wherein the antibody and the fragment has a heavy chain variable region having heavy chain CDR1 having the amino acid sequence set forth in SEQ ID NO: 1, heavy chain CDR2 having the amino acid sequence set forth in SEQ ID NO: 2 and heavy chain CDR3 having the amino acid sequence set forth in SEQ ID NO: 3, and a light chain variable region having light chain CDR1 having the amino acid sequence set forth in SEQ ID NO: 5, light chain CDR2 having the amino acid sequence set forth in SEQ ID NO: 6 and light chain CDR3 having the amino acid sequence set forth in SEQ ID NO: 7.