Patent ID: 11890351
Assignee: THE TRUSTEES OF BOSTON COLLEGE
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 10:
11. A chemoselectively labeled antibody conjugate, or antibody fragment conjugate, wherein the antibody, or antibody fragment comprises naturally-occurring amino acids and one, or more, non-naturally-occurring amino acids comprising a surface-exposed 5-hydroxytryptophan or a 5-aminotryptophan moiety incorporated into the antibody, wherein the non-naturally-occurring amino acid comprising 5-hydroxytryptophan or the 5-aminotryptophan is chemoselectively modified over the naturally-occurring amino acids of the biomolecule, wherein 5-hydroxytryptophan or the 5-aminotryptophan is covalently coupled to a detectably-labeled aryl-diazonium compound selected from the group consisting of: 4-nitrobenzenediazonium (4NDz); 4-carboxybenzenediazonium (4NCDz) or 4-methoxybenzenediazonium (4MCDz).