Patent ID: 11931349
Assignee: DEUTSCHES KREBSFORSCHUNGSZENTRUM STIFTUNG DES öFFENTLICHEN RECHTS
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 0:
1. A method for treating cancer in a subject comprising contacting hypoxic cancer cells in the subject with a pharmaceutically compatible iron chelator or a prodrug thereof, wherein the subject is suspected or known to comprise hypoxic cancer cells, wherein the pharmaceutically compatible iron chelator or prodrug thereof comprises a structure (I), wherein:
n is 0, 1, 2, 3, 4, 5, or 6;
R1 is H, optionally substituted carbonyl, optionally substituted phosphoryl, or optionally substituted sulfonyl;
R2 is selected from cyclohexyl, —H, C1-C6 alkyl, C5-C8 cycloalkyl, C1-C6 alkoxy, and halogen;
R4 is selected from methyl, —H, C1-C6 alkyl, C5-C8 cycloalkyl, C1-C6 alkoxy, and halogen; and
R3 and R5 are independently selected from —H, C1-C6 alkyl, C5-C8 cycloalkyl, C1-C6 alkoxy, and halogen.