Patent ID: 11912744
Assignee: ANTIBIOTIC ALTERNATIVES LLC
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A  Y | IPC A  C

Claim 23:
24. A method for treating a pathogen infection in a subject comprising:
introducing into a mucosal squamous epithelial cell of the subject a composition comprising (i) at least one in vitro transcribed isolated mRNA that comprises a synthetic 5′ cap and that encodes at least two polypeptides, wherein the polypeptides comprise CAMP and calprotectin, and (ii) a pharmaceutically acceptable in vivo delivery vehicle, wherein introducing comprises topically applying the composition to the mucosal squamous epithelial cell,
whereby the introduction of the composition provides transfection in vivo of the isolated mRNA to express the polypeptides in the cell in an amount effective to treat the pathogen infection in the transfected mucosal squamous epithelial cell.