Patent ID: 11891665
Assignee: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
Field: Measurement (Instruments)
Classification: CPC C  G | IPC C  G

Claim 0:
1. A method for treating a subject with an altered risk of Latent autoimmune diabetes (LADA) over Type 1 Diabetes (T1D), the method comprising;
a) providing a biological sample comprising nucleic acids obtained from a subject having diabetic symptoms;
b) genotyping said sample for MHC HLA haplotypes HLA-DQB1*0302, HLA-DQB1*0201, HLA-DRB1*1501, HLA-B*3906 and HLA-A*11;
c) identifying from said genotyping that the said subject lacks HLA-B*3906 and HLA-A*11 biomarkers, absence of said HLA-B*3906 and HLA-A*11 being indicative of an increased risk of LADA over T1D; and
d) after steps b) and c), treating the subject with an agent which modulates LADA symptoms.