Patent ID: 11858912
Assignee: HOFFMANN-LA ROCHE, INC.
Field: Organic fine chemistry (Chemistry)
Classification: CPC C  A  Y | IPC A  C

Claim 11:
12. The compound of formula (I) according to claim 1, or a pharmaceutically acceptable salt thereof, wherein:
X is C—R5;
R1 and R2, taken together with the nitrogen atom to which they are attached, form, R3 is chloro;
R4 is fluoro or chloro;
R5 and RE are fluoro;
R6 is selected from the group consisting of hydrogen, methyl, and, R7 is selected from the group consisting of hydrogen, 2-methoxyethyl, and, R8 is selected from the group consisting of hydrogen, chloro, methyl, and difluoromethyl;
R9, R10, RA4, RA5, and RB2 are hydrogen;
RA1 is (RA6)3N+—(CH2)3—C(O)— or, RA1 is selected from the group consisting of hydroxy, methyl, 2-amino-2-oxo-ethyl, and, RA2 is selected from the group consisting of methyl, carboxymethyl, and 2-amino-2-oxo-ethyl;
RA3 is hydrogen or methyl;
each RA6 is independently aminopropyl or carboxymethyl;
RA3 is hydrogen or fluoro;
LA is carbonyl;
LB is —CH2— or —NH—C(O)—CH2—;
LE is a covalent bond;
A1 is selected from the group consisting of pyrrolidinyl, piperazinyl, piperidinyl, and 3-azabicyclo[3.1.0]hexan-6-yl;
A2 is azetidinyl;
B is pyridyl or pyridazinyl;
D is pyrazolyl; and
E is phenyl.