Patent ID: 11939307
Assignee: INSTITUTE OF MEDICINAL BIOTECHNOLOGY, CHINESE ACADEMY OF MEDICAL SCIENCES
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC C

Claim 10:
11. The compound or the pharmaceutically acceptable salt thereof as claimed in claim 1, which is:
1-(3-((4-(1-(4-bromophenyl)ethyl)piperazin-1-yl)methyl)-4-(trifluoromethyl)phenyl)-4-methyl-1,4-diazepane
1-(3-((4-(4-chlorobenzyl)piperazin-1-yl)methyl)-4-(trifluoromethyl)phenyl)-4-methyl-1,4-diazepane
1-(3-((4-(1-(3-chloro-4-fluorophenyl)ethyl)piperazin-1-yl)methyl)-4-(trifluoromethyl)phenyl)-4-methyl-1,4-diazepane
1-(3-((4-(4-chloro-3-methylbenzyl)piperazin-1-yl)methyl)-4-(trifluoromethyl)phenyl)-4-methyl-1,4-diazepane
1-(3-((4-(1-(4-methoxyphenyl)butyl)piperazin-1-yl)methyl)-4-(trifluoromethyl)phenyl)-4-methyl-1,4-diazepane
1-(3,4-dichlorobenzyl)-4-(5-(4-methylpiperazin-1-yl)-2-(trifluoromethyl)benzyl)piperazine
1-(3-((4-(4-chlorobenzyl)piperidin-1-yl)methyl)-4-(trifluoromethyl)phenyl)-4-methyl-1,4-diazepane
N1-(3-((4-(1-(4-bromophenyl)propyl)piperazin-1-yl)methyl)-4-(trifluoromethyl)phenyl)-N1,N2,N2-trimethylethan-1,2-diamine
N1-(3-((4-(1-(4-chlorophenyl)ethyl)piperazin-1-yl)methyl)-4-(trifluoromethyl)phenyl)-N1,N2,N2-trimethylethan-1,2-diamine
N1,N1,N2-trimethyl-N2-(3-((4-(4-methylbenzyl)piperazin-1-yl)methyl)-4-(trifluoromethyl)phenyl)ethan-1,2-diamine
2-((4-(4-chloro-3-methylbenzyl)piperazin-1-yl)methyl)-4-(4-ethylpiperazin-1-yl)benzonitrile
2-((4-(4-chlorobenzyl)piperazin-1-yl)methyl)-4-(4-cyclopropylpiperazin-1-yl)benzonitrile
2-((4-(1-(4-chlorophenyl)ethyl)piperazin-1-yl)methyl)-4-((2-(ethyl(methyl)amino)ethyl)(methyl)amino)benzonitrile
4-(3-(dimethylamino)piperidin-1-yl)-2-((4-(1-phenylethyl)piperazin-1-yl)methyl)benzonitrile
4-((2-(dimethylamino)ethyl)(methyl)amino)-2-((4-(1-(4-(trifluoromethyl)phenyl)ethyl)piperazin-1-yl)methyl)benzonitrile
2-((4-(1-(4-chlorophenyl)-2-methylpropyl)piperazin-1-yl)methyl)-4-(methyl(2-(pyrrolidin-1-yl)ethyl)amino)benzonitrile
2-((4-(3-chloro-4-fluorobenzyl)piperazin-1-yl)methyl)-4-((2-(diethylamino)ethyl)(methyl)amino)benzonitrile
4-((3-(1H-pyrrol-1-yl)propyl)amino)-2-((4-(3,4-dichlorobenzyl)piperazin-1-yl)methyl)benzonitrile
1-(3-((4-(bis(4-methylphenyl)methyl)piperazin-1-yl)methyl)-4-(trifluoromethyl) phenyl)-4methyl-1,4-diazepane
1-(3-((4-(bis(4-methylphenyl)methyl)piperazin-1-yl)methyl)-4-(trifluoromethyl) phenyl)-4-methyl-1,4-diazepane
1-(3-((4-(bis(4-chlorophenyl)methyl)piperazin-1-yl)methyl)-4-(trifluoromethyl)phenyl)-4-methyl-1,4-diazepane
1-(3-((4-(bis(4-bromophenyl)methyl)piperazin-1-yl)methyl)-4-(trifluoromethyl)phenyl)-4-methyl-1,4-diazepane
1-(3-((4-(bis(4-isopropylphenyl)methyl)piperazin-1-yl)methyl)-4-(trifluoromethyl)phenyl)-4-methyl-1,4-diazepane
N1-(3-((4-(bis(4-cyclopropylphenyl)methyl)piperazin-1-yl)methyl)-4-(trifluoromethyl)phenyl)-N1,N2, N2-trimethylethan-1,2-diamine
N-(2-(azetidin-1-yl)ethyl)-3-((4-(bis(4-chlorophenyl)methyl)piperazin-1-yl)methyl)-N-methyl-4-(trifluoromethyl)aniline
1-(3-((4-((4-fluorophenyl)(phenyl)methyl)piperazin-1-yl)methyl)-4-(trifluoromethyl)phenyl)-4-methyl-1,4-diazepane
N1-(3-((4-(bis(4-chlorophenyl)methyl)piperazin-1-yl)methyl)-4-(trifluoromethyl)phenyl)-N1,N2, N2-trimethylethan-1,2-diamine
N1-(3-((4-(bis(4-(trifluoromethyl)phenyl)methyl)piperazin-1-yl)methyl)-4-(trifluoromethyl)phenyl)-N1,N2, N2-trimethylethan-1,2-diamine
N1-(3-((4-((4-chlorophenyl)(phenyl)methyl)piperazin-1-yl)methyl)-4-(trifluoromethyl)phenyl)-N1,N2, N2-trimethylethan-1,2-diamine
1-(bis(4-chlorophenyl)methyl)-4-(5-(4-methylpiperazin-1-yl)-2-(trifluoromethyl)benzyl)piperazine
1-(3-((4-((4-chlorophenyl)(pyridin-2-yl)methyl)piperazin-1-yl)methyl)-4-(trifluoromethyl)phenyl)-4-methyl-1,4-diazepane
1-methyl-4-(3-((4-(phenyl(pyridin-2-yl)methyl)piperazin-1-yl)methyl)-4-(trifluoromethyl)phenyl)-1,4-diazepane
N1-(3-((4-(bis(4-methoxyphenyl)methyl)piperazin-1-yl)methyl)-4-(trifluoromethyl)phenyl)-N1,N2, N2-trimethylethan-1,2-diamine
N1-(3-((4-(bis(4-chlorophenyl)methyl)piperazin-1-yl)methyl)-4-(trifluoromethyl)phenyl)-N2,N2-dimethyl-N1-propylethan-1,2-diamine
1-(3-((4-(bis(4-fluorophenyl)methyl)-2-methylpiperazin-1-yl)methyl)-4-(trifluoromethyl)phenyl)-4-methyl-1,4-diazepane
1-(3-((4-(bis(4-chlorophenyl)methyl)-2-methylpiperazin-1-yl)methyl)-4-(trifluoromethyl)phenyl)-4-methyl-1,4-diazepane
3-((4-(bis(4-chlorophenyl)methyl)piperazin-1-yl)methyl)-N-methyl-N-((1-methylpyrrolidin-2-yl)methyl)-4-(trifluoromethyl)aniline
3-((4-(bis(4-chlorophenyl)methyl)piperazin-1-yl)methyl)-N-methyl-N-(2-(pyrrolidin-1-yl)ethyl)-4-(trifluoromethyl)aniline
N-(2-(aziridin-1-yl)ethyl)-3-((4-(bis(4-chlorophenyl)methyl)piperazin-1-yl)methyl)-N-methyl-4-(trifluoromethyl)aniline
1-(3-((4-(di(pyridin-2-yl)methyl)piperazin-1-yl)methyl)-4-(trifluoromethyl)phenyl)-4-ethyl-1,4-diazepane
N1-(3-((4-(bis(4-fluorophenyl)methyl)piperazin-1-yl)methyl)-4-(trifluoromethyl)phenyl)-N1,N2, N2-trimethylethan-1,2-diamine
1-(3-((4-(bis(4-chlorophenyl)methyl)piperazin-1-yl)methyl)-4-(trifluoromethyl)phenyl)-N, N-dimethylpiperidin-3-amine
1-(bis(4-bromophenyl)methyl)-4-(5-(4-methylpiperazin-1-yl)-2-(trifluoromethyl)benzyl)piperazine
1-(3-((4-(bis(4-fluorophenyl)methyl)piperazin-1-yl)methyl)-4-(trifluoromethyl)phenyl)-N, N-dimethylpiperidin-4-amine
N1-(3-((4-(bis(4-chlorophenyl)methyl)piperazin-1-yl)methyl)-4-(trifluoromethyl)phenyl)-N1,N2-dimethyl-N2-propylethan-1,2-diamine
N1-(3-((4-(bis(4-fluorophenyl)methyl)piperazin-1-yl)methyl)-4-(trifluoromethyl)phenyl)-N2-(2-(dimethylamino)ethyl)-N1,N2-dimethylethan-1,2-diamine
N1-(3-((4-(bis(4-chlorophenyl)methyl)piperidin-1-yl)methyl)-4-(trifluoromethyl)phenyl)-N1,N2, N2-trimethylethan-1,2-diamine
N1-(3-((4-(bis(4-bromophenyl)methyl)piperidin-1-yl)methyl)-4-(trifluoromethyl)phenyl)-N1,N2, N2-trimethylethan-1,2-diamine
2-((4-(bis(4-chlorophenyl)methyl)piperazin-1-yl)methyl)-4-((2-(dimethylamino)ethyl)(methyl)amino)benzonitrile
2-((4-(bis(4-methoxyphenyl)methyl)piperazin-1-yl)methyl)-4-(4-methyl-1,4-diazepan-1-yl)benzonitrile
2-((4-(bis(4-fluorophenyl)methyl)piperazin-1-yl)methyl)-4-(4-methyl-1,4-diazepan-1-yl)benzonitrile
2-((4-(bis(4-chlorophenyl)methyl)piperazin-1-yl)methyl)-4-(4-methyl-1,4-diazepan-1-yl)benzonitrile
4-((2-(1H-imidazol-1-yl)ethyl)(methyl)amino)-2-((4-(bis(4-chlorophenyl)methyl)piperazin-1-yl)methyl)benzonitrile
2-((4-(di(pyridin-4-yl)methyl)piperazin-1-yl)methyl)-4-((2-(dimethylamino)ethyl)(methyl)amino)benzonitrile
2-((4-(bis(4-chlorophenyl)methyl)piperazin-1-yl)methyl)-4-(4-methylpiperazin-1-yl)benzonitrile
2-((4-(bis(4-isopropylphenyl)methyl)piperazin-1-yl)methyl)-4-((2-(dimethylamino)ethyl)(methyl)amino)benzonitrile
2-((4-(bis(4-tert-butylphenyl)methyl)piperazin-1-yl)methyl)-4-((2-(dimethylamino)ethyl)(methyl)amino)benzonitrile
2-((4-(bis(4-bromophenyl)methyl)piperazin-1-yl)methyl)-4-((2-(dimethylamino)ethyl)(methyl)amino)benzonitrile
2-((4-(bis(4-cyclopropylphenyl)methyl)piperazin-1-yl)methyl)-4-((2-(dimethylamino)ethyl)(methyl)amino)benzonitrile
2-((4-(bis(4-chlorophenyl)methyl)piperazin-1-yl)methyl)-4-(3-(dimethylamino)pyrrolidin-1-yl)benzonitrile
2-((4-(bis(4-chlorophenyl)methyl)piperazin-1-yl)methyl)-4-(methyl(2-(pyrrolidin-1-yl)ethyl)amino)benzonitrile
4-((2-(aziridin-1-yl)ethyl)(methyl)amino)-2-((4-(bis(4-chlorophenyl)methyl)piperazin-1-yl)methyl)benzonitrile
2-((4-((4-chlorophenyl)(phenyl)methyl)piperazin-1-yl)methyl)-4-(4-methyl-1,4-diazepan-1-yl)benzonitrile
2-((4-((4-chlorophenyl)(pyridin-4-yl)methyl)piperazin-1-yl)methyl)-4-(4-methyl-1,4-diazepan-1-yl)benzonitrile
2-((4-(bis(4-chlorophenyl)methyl)piperidin-1-yl)methyl)-4-((2-(dimethylamino)ethyl)(methyl)amino)benzonitrile
2-((4-(bis(4-fluorophenyl)methyl)piperidin-1-yl)methyl)-4-(4-methyl-1,4-diazepan-1-yl)benzonitrile
N-{3-[4-(4-chlorophenyl)piperazin-1-yl]methyl)-4-(trifluoromethyl)phenyl}-N,1-dimethylpyrrolidin-3-amine
4-[{2-[ethyl(methyl)amino]ethyl}(methyl)amino)-2-({4-[1-(pyrazin-2-yl)ethyl]piperazin-1-yl}methyl)benzonitrile
N1-(3-[{4-[bis(3,4-dichlorophenyl)methyl]piperazin-1-yl}methyl]-4-(trifluoromethyl)phenyl)-N2,N2-diethyl-N1-methylethan-1,2-diamine
2-({4-[bis(4-chloro-3-methylphenyl)methyl]piperazin-1-yl}methyl)-4-{[2-(dimethylamino)ethyl](methyl)amino}benzonitrile
1-[3-({4-[cyclohexyl(3,4-dichlorophenyl)methyl]piperazin-1-yl}methyl)-4-(trifluoromethyl)phenyl]-4-methyl-1,4-diazepane
2-({4-[(4-chlorophenyl)(cyclobutyl)methyl]piperazin-1-yl}methyl)-4-(4-methyl-1,4-diazepan-1-yl)benzonitrile
2-[(4-chlorophenyl){4-(5-(4-methylpiperazin-1-yl)-2-(trifluoromethyl)benzyl]piperazin-1-yl}methyl]pyrazine
4-(4-methylpiperazin-1-yl)-2-[(4-{(pyrazin-2-yl)[(4-(trifluoromethyl)phenyl]methyl}piperazin-1-yl)methyl]benzonitrile
1-methyl-4-[3-({4-[(4-phenoxyphenyl)(pyridin-2-yl)methyl]piperazin-1-yl}methyl)-4-(trifluoromethyl)phenyl]-1,4-diazepane
N-{3-([4-{bis[4-(phenylthio)phenyl]methyl}piperazin-1-yl]methyl)-4-(trifluoromethyl)phenyl}-1-ethyl-N-methylpyrrolidin-3-amine
2-({4-(bis(4-(methylthio)phenyl]methyl}piperazin-1-yl)methyl)-4-{[2-(dimethylamino)ethyl](methyl)amino}benzonitrile
3-([4-{bis[4-(trifluoromethyl)phenyl]methyl}piperazin-1-yl]methyl)-N-methyl-N-[2-(pyrrolidin-1-yl)ethyl]-4-(trifluoromethyl)aniline
2-({4-[(4-cyanophenyl)(cyclopentyl)methyl]piperazin-1-yl}methyl)-4-{[2-(dimethylamino)ethyl](methyl)amino}benzonitrile
4-{1-(4-[5-{[2-(dimethylamino)ethyl](methyl)amino}-2-(trifluoromethyl)benzyl]piperazin-1-yl)ethyl}benzonitrile
4-([3-(1H-imidazol-1-yl)propyl]amino)-2-({4-[bis(4-chlorophenyl)methyl]piperazin-1-yl}methyl)benzonitrile.