Patent ID: 11958914
Assignee: H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 2:
3. The polypeptide of claim 1, wherein the polypeptide is a chimeric antigen receptor (CAR) polypeptide defined by the formula:

SP—GBP—HG—TM—CSR—ISD; or

SP—GBP—HG—TM—ISD—CSR

wherein “SP” represents a signal peptide,
wherein “GBP” represents a GSC-binding peptide,
wherein “HG” represents and optional hinge domain,
wherein “TM” represents a transmembrane domain,
wherein “CSR” represents a co-stimulatory signaling region,
wherein “ISD” represents an intracellular signaling domain, and
wherein “—” represents a bivalent linker.