Patent ID: 11859006
Assignee: DAIICHI SANKYO COMPANY, LIMITED
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A  G | IPC A  C

Claim 11:
12. The method of claim 2, wherein the anti-ALK2 antibody or the antigen-binding fragment thereof comprises a heavy chain variable region comprising:
a1) an amino acid sequence consisting of amino acid residues from position 20 to position 142 of the amino acid sequence of SEQ ID NO: 31,
a2) an amino acid sequence consisting of amino acid residues from position 20 to position 142 of the amino acid sequence of SEQ ID NO: 33,
a3) an amino acid sequence consisting of amino acid residues from position 20 to position 140 of the amino acid sequence of SEQ ID NO: 34,
a4) an amino acid sequence consisting of amino acid residues from position 20 to position 140 of the amino acid sequence of SEQ ID NO: 36,
a5) an amino acid sequence consisting of amino acid residues from position 20 to position 140 of the amino acid sequence of SEQ ID NO: 38,
a6) an amino acid sequence consisting of amino acid residues from position 20 to position 140 of the amino acid sequence of SEQ ID NO: 39,
a7) an amino acid sequence having at least 95% identity to any one amino acid sequence selected from the amino acid sequences a1) to a6),
a8) an amino acid sequence having at least 99% identity to any one amino acid sequence selected from the amino acid sequences a1) to a6), or
a9) an amino acid sequence comprising a substitution(s), a deletion(s), or an addition(s) of one or several amino acid residues in any one amino acid sequence selected from the amino acid sequences a1) to a6); and
the anti-ALK2 antibody or the antigen-binding fragment thereof comprises a light chain variable region comprising:
b1) an amino acid sequence consisting of amino acid residues from position 21 to position 133 of the amino acid sequence of SEQ ID NO: 32,
b2) an amino acid sequence consisting of amino acid residues from position 21 to position 129 of the amino acid sequence of SEQ ID NO: 35,
b3) an amino acid sequence consisting of amino acid residues from position 21 to position 129 of the amino acid sequence of SEQ ID NO: 37,
b4) an amino acid sequence having at least 95% identity to any one amino acid sequence selected from the amino acid sequences b1) to b3),
b5) an amino acid sequence having at least 99% identity to any one amino acid sequence selected from the amino acid sequences b1) to b3), or
b6) an amino acid sequence comprising a substitution(s), a deletion(s), or an addition(s) of one or several amino acid residues in any one amino acid sequence selected from the amino acid sequences b1) to b3).