Patent ID: 11897880
Assignee: JANSSEN PHARMACEUTICA NV
Field: Organic fine chemistry (Chemistry)
Classification: CPC C | IPC C

Claim 0:
1. A compound of formula (I), wherein
R1 is selected from the group consisting of hydrogen, C1-2alkyl, —(C1-2alkylene)-OH and —(C1-2alkylene)-O-(C1-2alkyl);
R2 is hydrogen and R3 is cyclopropyl-methyl-;
alternatively, R2 and R3 are taken together with the carbon atoms to which they are bound to form, R4 is selected from the group consisting of hydrogen and halogen;
R5 is selected from the group consisting of phenyl, heteroaryl and pyridin-4-yl-1-oxide;
wherein the phenyl or heteroaryl is optionally substituted with one or more substituents independently selected from the group consisting of halogen, hydroxy, oxo, C1-4alkyl, hydroxy substituted C1-4alkyl, NRARB and —NH—C(O)-(C1-4alkyl); wherein RA and RB are each independently selected from the group consisting of hydrogen and C1-2alkyl;
a is an integer from 0 to 3;
each R6 is independently selected from the group consisting of chloro, fluoro and methyl;
R7 is hydrogen, and R8 and R9 are each independently selected from the group consisting of hydrogen, C1-4alkyl, and C1-4alkoxy;
alternatively, R7 is hydrogen, and R8 and R9 are taken together with the carbon atom to which they are bound to form a ring structure selected from the group consisting of cycloprop-1,1-diyl, cyclobut-1,1-diyl, cyclopent-1,1-diyl, and cyclohex-1,1-yl;
alternatively, R9 is hydrogen, and R7 and R8 are taken together with the carbon atoms to which they are bound to form a ring structure selected from the group consisting of phen-1,2-diyl and pyridin-3,4-diyl;
or a stereoisomer, isotopologue, isotopomer, or pharmaceutically acceptable salt or solvate thereof.