Patent ID: 11919887
Assignee: VERTEX PHARMACEUTICALS INCORPORATED
Field: Organic fine chemistry (Chemistry)
Classification: CPC C  A | IPC C

Claim 4:
5. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein the compound is selected from, (2R,3R,4R,5S)-N-(3-carbamoyl-4-fluorophenyl)-3-(2-difluoromethoxy)-3,4-difluorophenyl)-4,5-dimethyl-5-(trifluorophenyl)tetrahydrofuran-2-carboxamide, (2S,3R,4R,5S)-N-(3-carbamoyl-4-fluorophenyl)-3-(2-difluoromethoxy)-3,4-difluorophenyl)-4,5-dimethyl-5-(trifluorophenyl)tetrahydrofuran-2-carboxamide, (2R,3S,4R,5S)-N-(3-carbamoyl-4-fluorophenyl)-3-(2-difluoromethoxy)-3,4-difluorophenyl)-4,5-dimethyl-5-(trifluorophenyl)tetrahydrofuran-2-carboxamide, (2R,3R,4S,5S)-N-(3-carbamoyl-4-fluorophenyl)-3-(2-difluoromethoxy)-3,4-difluorophenyl)-4,5-dimethyl-5-(trifluorophenyl)tetrahydrofuran-2-carboxamide, (2R,3R,4R,5R)-N-(3-carbamoyl-4-fluorophenyl)-3-(2-difluoromethoxy)-3,4-difluorophenyl)-4,5-dimethyl-5-(trifluorophenyl)tetrahydrofuran-2-carboxamide, (2S,3S,4R,5S)-N-(3-carbamoyl-4-fluorophenyl)-3-(2-difluoromethoxy)-3,4-difluorophenyl)-4,5-dimethyl-5-(trifluorophenyl)tetrahydrofuran-2-carboxamide, (2S,3R,4S,5S)-N-(3-carbamoyl-4-fluorophenyl)-3-(2-difluoromethoxy)-3,4-difluorophenyl)-4,5-dimethyl-5-(trifluorophenyl)tetrahydrofuran-2-carboxamide, (2S,3R,4R,5R)-N-(3-carbamoyl-4-fluorophenyl)-3-(2-difluoromethoxy)-3,4-difluorophenyl)-4,5-dimethyl-5-(trifluorophenyl)tetrahydrofuran-2-carboxamide, (2R,3S,4S,5S)-N-(3-carbamoyl-4-fluorophenyl)-3-(2-difluoromethoxy)-3,4-difluorophenyl)-4,5-dimethyl-5-(trifluorophenyl)tetrahydrofuran-2-carboxamide, (2R,3S,4R,5R)-N-(3-carbamoyl-4-fluorophenyl)-3-(2-difluoromethoxy)-3,4-difluorophenyl)-4,5-dimethyl-5-(trifluorophenyl)tetrahydrofuran-2-carboxamide, (2R,3R,4S,5R)-N-(3-carbamoyl-4-fluorophenyl)-3-(2-difluoromethoxy)-3,4-difluorophenyl)-4,5-dimethyl-5-(trifluorophenyl)tetrahydrofuran-2-carboxamide, (2S,3S,4S,5S)-N-(3-carbamoyl-4-fluorophenyl)-3-(2-difluoromethoxy)-3,4-difluorophenyl)-4,5-dimethyl-5-(trifluorophenyl)tetrahydrofuran-2-carboxamide, (2S,3S,4R,5R)-N-(3-carbamoyl-4-fluorophenyl)-3-(2-difluoromethoxy)-3,4-difluorophenyl)-4,5-dimethyl-5-(trifluorophenyl)tetrahydrofuran-2-carboxamide, (2S,3R,4S,5R)-N-(3-carbamoyl-4-fluorophenyl)-3-(2-difluoromethoxy)-3,4-difluorophenyl)-4,5-dimethyl-5-(trifluorophenyl)tetrahydrofuran-2-carboxamide, (2R,3S,4S,5R)-N-(3-carbamoyl-4-fluorophenyl)-3-(2-difluoromethoxy)-3,4-difluorophenyl)-4,5-dimethyl-5-(trifluorophenyl)tetrahydrofuran-2-carboxamide, and, (2S,3S,4S,5R)-N-(3-carbamoyl-4-fluorophenyl)-3-(2-difluoromethoxy)-3,4-difluorophenyl)-4,5-dimethyl-5-(trifluorophenyl)tetrahydrofuran-2-carboxamide.