Patent ID: 11866494
Assignee: INNOVATIVE CELLULAR THERAPEUTICS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A modified cell comprising a first nucleic acid encoding a chimeric antigen receptor (CAR) and a second nucleic acid encoding an agent binding a first co-stimulatory molecule,
wherein the CAR comprises an extracellular domain, a transmembrane domain, and an intracellular domain, the extracellular domain binds an antigen, and the intracellular domain comprises an intracellular domain of a first co-stimulatory molecule and a second co-stimulatory molecule,
wherein the first co-stimulatory molecule is GITR, and the second co-stimulatory molecule is 4-1BB, and the agent binding the first co-stimulatory molecule is glucocorticoid-induced TNFR-related protein ligand (GITRL), and
wherein the modified cell comprises a nucleic acid encoding the amino acid sequences SEQ ID NOs: 1, 2, 3, 5, 4, and 8 in 5′ to 3′ order.