Patent ID: 11951172
Assignee: CRESCENDO BIOLOGICS LIMITED
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 21:
22. An isolated human heavy chain variable domain (VH) single domain antibody that binds to human LAG-3 The single domain antibody according to claim 1 comprising a sequence a shown in SEQ ID NO: 4 comprising a S23A substitution or a sequence a shown in SEQ ID NO: 4 comprising S23A, N57S, and S58T substitutions or a sequence a shown in SEQ ID NO: 4 comprising S23A and N54I substitutions or a sequence a shown in SEQ ID NO: 4 comprising S23A, D30N, Y32F, and S58T substitutions or a sequence a shown in SEQ ID NO: 4 comprising S23A, Y32F, G55S, G56D, N57I, S58T, and G59A substitutions or a sequence a shown in SEQ ID NO: 4 comprising S23A, Y32F, S58T, S106V, and S108A substitutions or a sequence a shown in SEQ ID NO: 4 comprising S23A, D30N, and A107T substitutions or a sequence a shown in SEQ ID NO: 4 comprising S23A, Y95H, G56D, N57S, and S58T substitutions or a sequence a shown in SEQ ID NO: 8.