Patent ID: 11931548
Assignee: ANAS EL FATHI
Field: Medical technology (Instruments)
Classification: CPC A  G | IPC A  G

Claim 10:
11. A system for determining recommended multiple daily injections (MDI) therapy values for administering to a given subject, the system comprising:
a processor;
a non-transitory computer-readable storage medium operatively connected to the processor, the computer-readable storage medium comprising instructions;
an input/output interface operatively connected to the processor;
the system being operatively connected to a continuous glucose monitor (CGM) and an infusion pump, the processor, upon executing the instructions, being configured for:
receiving data values relating to a consumed meal by the given subject, an insulin basal dose administered to the given subject, and an insulin bolus dose administered to the given subject;
receiving an initial meal ratio parameter and an initial basal insulin dose used by the given subject;
predicting, using a computer model of the glucoregulatory system of the given subject, based on data values relating to the consumed meal by the given subject, the insulin basal dose, the insulin bolus dose, and the initial meal ratio parameter, a predicted glucose concentration parameter representative of predicted blood glucose concentration of the given subject after the consumed meal and administration of the insulin bolus dose and the insulin basal dose;
receiving, from the CGM, an actual glucose concentration parameter representative of an actual blood glucose concentration measurement of the given subject;
estimating, by a run-to-run (R2R) control algorithm using the computer model of the glucoregulatory system of the given subject based on the predicted glucose concentration parameter and the actual glucose concentration parameter, a set of optimal MDI therapy parameters; and
determining, based on the set of optimal MDI therapy parameters, a set of recommended MDI therapy parameters, the set of recommended MDI therapy parameters comprising an optimal meal ratio parameter to be consumed by the given subject, and an optimal basal insulin dose to be administered to the given subject;
outputting, to the input/output interface, the set of recommended MDI therapy parameters to the subject; and
transmitting, to the artificial pancreas system, a control command to cause the infusion pump to inject the optimal basal insulin dose to the subject.