Patent ID: 11932873
Assignee: INNOVATIVE CELLULAR THERAPEUTICS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A modified cell that comprises a modified programmed cell death protein 1 (PD-1), wherein:
the modified PD-1 comprises an extracellular domain of PD-1 and a cytoplasmic domain of the PD-1 polypeptide that is truncated, or
the modified cell comprises a partial deletion of the PD-1 gene and a reduced amount of PD-1 as compared to the corresponding wild-type cell, or comprises a non-functional PD-1 gene, and
wherein the modified PD-1 comprises an extracellular domain and
(i) one of SEQ ID NOs: 12-14; or
(ii) does not comprise SEQ ID NO: 15 or 16.