Patent ID: 11912757
Assignee: HUMABS BIOMED SA
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A  G  Y | IPC A  C  G

Claim 30:
31. An antibody, or an antigen binding fragment thereof, that specifically binds to a Zika virus EDIII epitope, wherein the antibody or antigen binding fragment thereof comprises:
(a) a heavy chain variable region (VH) amino acid sequence SEQ ID NO: 26;
(b) a light chain variable region (VL) amino acid sequence SEQ ID NO: 27; and
(c) an Fc moiety comprising a mutation at at least one of E233-G236, P238, D265, N297, A327, P329, D270, Q295, A327, R292, S239, E269, E293, Y296, V303, A327, P331, K338 and D376, and K414, wherein the mutation reduces binding of the antibody or antigen binding fragment to an FcγRI, an FcγRIIa, an FcγRIIIa, or any combination thereof.