Patent ID: 11945876
Assignee: INSTIL BIO, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A chimeric costimulatory antigen receptor (CoStAR) which comprises:
an extracellular binding domain that binds to carcinoembryonic antigen (CEA);
operatively linked to ICOS, wherein ICOS comprises the amino acid sequence of SEQ ID NO: 515; and
a CD40 signaling domain, wherein the CD40 signaling domain comprises the amino acid sequence of SEQ ID NO: 32,
wherein ICOS is linked to the CD40 signaling domain, and wherein the extracellular binding domain comprises:
a HCDR1 that is an HCDR1 in SEQ ID NO: 12;
a HCDR2 that is an HCDR2 in SEQ ID NO: 12;
a HCDR3 that is an HCDR3 in SEQ ID NO: 12;
a LCDR1 that is an LCDR1 in SEQ ID NO: 12;
a LCDR2 that is an LCDR2 in SEQ ID NO: 12; and
a LCDR3 that is an HCDR3 in SEQ ID NO: 12.