Patent ID: 11865185
Assignee: NANTES UNIVERSITE
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 10:
11. A method for chemically coupling an Adeno-Associated Virus (AAV) vector particle with at least one ligand L, said method comprising at least the steps of:
having an Adeno-Associated Virus (AAV) particle having at least one primary amino group contained in the capsid proteins, and
contacting said AAV particle with a reagent of formula (II)

B—N═C═S  (II), wherein B is a radical (L)m(X)Ar—
with
L being as defined in claim 5,
m representing an integer from 1 to 1000,
Ar representing an arylene or heteroarylene radical, and
X representing a bond or a spacer between said ligand(s) L and Ar, in conditions suitable for reacting the primary amino group with the —N═C═S moiety of the reagent of formula (II).