Patent ID: 11883501
Assignee: MAINLINE BIOSCIENCES (SHANGHAI) CO., LTD.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 0:
1. A selective CXCR4 binding peptide conjugate (“PC”) of the formula:, or a pharmaceutically acceptable salt thereof,
wherein:
a is 0 or 1;
b is 1;
AA1 along with the sulfur atom that is attached thereto is 3-mercaptopropionic acid, optionally substituted cysteine, optionally substituted homocysteine, or optionally substituted penicillamine;
AA2 along with the sulfur atom that is attached thereto is cysteine or homocysteine;
Ar1 is phenylene;
X1 is Arg, Dap, Dab, Orn, Lys, Dap(iPr), Dab(iPr), Orn(iPr), or Lys(iPr);
AA3 is Lys(iPr);
AA4 is an amino acid or a derivative thereof;
Y1 is a side-chain function group of amino acid AA4;
L1a is a polyethylene glycol of about 2 to about 20 monomers;
L2 is a non-polymeric linker;
Z a medically useful compound; and
Y2 is a functional group of said medically useful compound or a functional group of L2;

and wherein one or more of AA1, AA2, X1, AA3, and AA4 are optionally isotopically labelled.