Patent ID: 11913884
Assignee: WILLIAM MARSH RICE UNIVERSITY
Field: Measurement (Instruments)
Classification: CPC G  C  A  B | IPC A  B  C  G

Claim 1:
2. The photoactivatable fluorophore of claim 1, wherein the photoactivatable fluorophore is further defined as:, , wherein:
X1 is —O—, —S—, —C(O)—, —C(S)—, or —NRa—, wherein:
Ra is hydrogen, alkyl(C≤8), substituted alkyl(C≤8), acyl(C≤8), or substituted acyl(C≤8);

X2 is —N=, —C(Rb)═, or —C(Rc)(Rd)— wherein:
Rb is hydrogen; or
alkyl(C≤8), substituted alkyl(C≤8), aryl(C≤12), or substituted aryl(C≤12);

Rc and Rd are taken together to form a group of the formula:, wherein:
n is 0, 1, 2, 3, or 4;
Re at each instance is independently hydrogen, halo, hydroxy, or amino; or
alkyl(C≤8), alkoxy(C≤8), alkylamino(C≤8), dialkylamino(C≤8), or a substituted version of any of these groups; or

Xa is —O— or —NRf—, wherein:
Rf is hydrogen; or
 alkyl(C≤8), substituted alkyl(C≤8), acyl(C≤8), or substituted acyl(C≤8); or
 -C(S)NHRg, wherein:
 Rg is alkyl(C≤8), substituted alkyl(C≤8), alkenyl(C≤8), or substituted alkenyl(C≤8);

R1 is hydrogen, halo, hydroxy, amino, nitro, or cyano; or
alkyl(C≤8), alkoxy(C≤8), alkylamino(C≤8), dialkylamino(C≤8), amido(C≤8), or a substituted version of any of these groups; or
—C(O)Rh, wherein;
Rh is hydroxy or amino; or
alkyl(C≤8), alkoxy(C≤8), alkylamino(C≤8), dialkylamino(C≤8), or a substituted version of any of these groups; and

R2, R3, R4, R5, R6, and R7 are each independently hydrogen, halo, hydroxy, amino, nitro, or cyano; or
alkyl(C≤8), alkoxy(C≤8), alkylamino(C≤8), dialkylamino(C≤8), amido(C≤8), or a substituted version of any of these groups; or
—C(O)Ri, wherein;
Ri is hydroxy or amino; or
alkyl(C≤8), alkoxy(C≤8), alkylamino(C≤8), dialkylamino(C≤8), or a substituted version of any of these groups; or

R2 and R3, R4 and R5, R5 and R6, or R6 and R7 are taken together to form an arene(C≤12), a substituted arene(C≤12), a heteroarene(C≤12), or a substituted heteroarene(C≤12);, or a pharmaceutically acceptable salt or tautomer thereof.