Patent ID: 11945831
Assignee: MELCHIOR MATERIAL AND LIFE SCIENCE FRANCE
Field: Organic fine chemistry (Chemistry)
Classification: CPC C | IPC C

Claim 4:
5. Preparation method for a compound brominated by bromination of a primary alcohol comprising the following steps:
1) mixing (a) 1 molar equivalent of adduct (I) according to claim 1 and (b) 1 to 3 volumes of polar solvent; then
2) adding dibromine:
2.1) cool with stirring the solution obtained in step 1) to a temperature comprised between 0° C. and 12° C., then
2.2) to the cooled solution obtained after step 2.1), add between 1.05 and 1.25 molar equivalents of dibromine while keeping the reaction medium temperature below 12° C.; then

3) adding the primary alcohol:
3.1) following step 2.2), lower the reaction medium temperature to a value comprised between 0° C. and −15° C.;
3.2) to the cooled reaction medium obtained following step 3.1), add between 0.95 and 1 molar equivalent of primary alcohol, then

4) Recovering brominated compound (A).