Patent ID: 11944665
Assignee: UNIVERSITY OF VIRGINIA PATENT FOUNDATION
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 0:
1. A method of increasing flow of fluid in the central nervous system (CNS) of a subject, wherein the subject has a disease or disorder selected the group consisting of Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS), meningitis, and autism, the method comprising:
administering an effective amount of a Vascular Endothelial Growth Factor Receptor 3 (VEGFR3) agonist to a meningeal space of the subject, wherein the VEGFR3 agonist is VEGF-c156S, wherein said administration is effective to increase fluid flow in the central nervous system of the subject as compared to pre-administration of the VEGFR3 agonist.