Patent ID: 11952416
Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC C

Claim 0:
1. An antibody which binds annexin A1, or an annexin A1-binding fragment thereof, or an annexin A1-binding fusion protein, comprising: a) a heavy chain comprising: CDR1 comprising the amino acid sequence in SEQ ID NO:2; CDR2 comprising the amino acid sequence in SEQ ID NO:4; CDR3 comprising the amino acid sequence in SEQ ID NO:6; and a light chain comprising: comprising the amino acid sequence in SEQ ID NO:8; CDR2 comprising the amino acid sequence SAS, SEQ ID NO:10; CDR3 comprising the amino acid sequence in SEQ ID NO:12; or
b) a heavy chain comprising: CDR1 comprising the amino acid sequence in SEQ ID NO:14; CDR2 comprising the amino acid sequence in SEQ ID NO:16; CDR3 comprising the amino acid sequence in SEQ ID NO:18; and a light chain comprising: CDR1 comprising the amino acid sequence in SEQ ID NO:20; CDR2 comprising the amino acid sequence DTS, SEQ ID NO:22; CDR3 comprising the amino acid sequence in SEQ ID NO:24; or
c) a heavy chain comprising: CDR1 comprising the amino acid sequence in SEQ ID NO:26; CDR2 comprising the amino acid sequence in SEQ ID NO:28; CDR3 comprising the amino acid sequence in SEQ ID NO:30; and a light chain comprising: CDR1 comprising the amino acid sequence in SEQ ID NO:32; CDR2 comprising the amino acid sequence GAT, SEQ ID NO:34; CDR3 comprising the amino acid sequence in SEQ ID NO:36.