Patent ID: 11872225
Assignee: AGIOS PHARMACEUTICALS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 5:
6. The method of claim 1, wherein Q is of one of the following formulae:, , wherein:
each instance of Rn is independently hydrogen, a halogen, —CN, —NO2, —N3, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted aryl, an optionally substituted heterocyclyl, an optionally substituted heteroaryl, —ORo4, —SRs1, —N(Rn2)2, —C(═O)N(Rn2)2, —N(Rn2)C(═O)Rc3, —C(═O)Rc3, —C(═O)ORo4, —OC(═O)Rc3, —S(═O)Rs1, —S(═O)2Rs1, —S(═O)ORo4, —OS(═O)Rc3, —S(═O)2ORo4, —OS(═O)2Rc3, —S(═O)N(Rn2)2, —S(═O)2N(Rn2)2, —N(Rn2)S(═O)Rs1, —N(Rn2)S(═O)2Rs1, —N(Rn2)C(═O)ORo4, —OC(═O)N(Rn2)2, —N(Rn2)C(═)N(Rn2)2, —N(Rn2)S(═O)N(Rn2)2, —N(Rn2)S(═O)2N(Rn2)2, —N(Rn2)S(═O)ORo4, —N(Rn2)S(═O)2ORo4, —OS(═O)N(Rn2)2, or —OS(═O)2N(Rn2)2; or two instances of Rn attached to the same or adjacent carbon atoms, taken together with the carbon atoms to which they are attached to form an optionally substituted cycloalkyl or a heterocycloalkyl; wherein:
each instance of Rn2 is independently hydrogen, an optionally substituted —C1-C6 alkyl, or a nitrogen protecting group;
each instance of Ro4 is independently hydrogen, an optionally substituted —C1-C6 alkyl, or an oxygen protecting group;
each instance of Rec3 is independently an optionally substituted —C1-C6 alkyl;
each instance of Rsl is independently an optionally substituted —C1-C6 alkyl or a sulfur protecting group;
n is 0, 1, 2, or 3, as valency permits; and
each of Rna, Rnb, and Rnd is independently hydrogen, an optionally substituted —C1-C6 alkyl, or a nitrogen protecting group.