Patent ID: 11858880
Assignee: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 1:
2. A method of inhibiting fungal sphingolipid synthesis in a fungus comprising contacting the fungus with an effective amount of the compound having the structure:, wherein
R1 is —H, alkyl, alkenyl, or alkynyl;
R2 is —H, alkyl, alkenyl, or alkynyl;
R3, R4, R5, and R6 are each independently —H, halogen, C1-C6 alkyl, —OH, —O—(C1-C6 alkyl), —CHF2, —CF3, —OCHF2 or —OCF3, or
R3 and R4 are each independently —H, halogen, C1-C6 alkyl, —OH, —O—(C1-C6 alkyl), —CHF2, —CF3, —OCHF2 or —OCF3, and R5 and R6 combine to form a fused aryl or fused heteroaryl, which are each unsubstituted or substituted, or
R3 and R6 are each independently —H, halogen, C1-C6 alkyl, —OH, —O—(C1-C6 alkyl), —CHF2, —CF3, —OCHF2 or —OCF3, and R4 and R5 combine to form a fused aryl or fused heteroaryl, which are each unsubstituted or substitute, or
R5 and R6 are each independently —H, halogen, C1-C6 alkyl, —OH, —O—(C4-C6 alkyl), —CHF2, —CF3, —OCHF2 or —OCF3, and R3 and R4 combine to form a fused aryl or fused heteroaryl, which are each unsubstituted or substituted; and
A is an aryl or heteroaryl, which are each unsubstituted or substituted,
wherein when R3, R4, and R6 are each —H and R5 is —OH or —OCH3, or R3, R5, and R6 are each —H and R4 is —Br, then A is other than ortho-tolyl or meta-bromophenyl, or a pharmaceutically acceptable salt or ester thereof, so as to thereby inhibit sphingolipid synthesis in the fungus.