Patent ID: 11963981
Assignee: AUTOLUS LIMITED
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 5:
6. A nucleic acid construct according to claim 5, wherein the antigen binding domain of the anti-CD19 CAR comprises:
a) a heavy chain variable region (VH) having complementarity determining regions (CDRs) with the following sequences:, (SEQ ID NO: 69)

CDR1 - GYAFSSS,

 

(SEQ ID NO: 70)

CDR2 - YPGDED,

and

 

(SEQ ID NO: 71)

CDR3 - SLLYGDYLDY,, and
b) a light chain variable region (VL) having CDRs with the following sequences:, (SEQ ID NO: 72)

CDR1 - SASSSVSYMH,

 

(SEQ ID NO: 73)

CDR2 - DTSKLAS,

and

 

(SEQ ID NO: 74)

CDR3 - QQWNINPLT.