Patent ID: 11919896
Assignee: ZHUHAI UNITED LABORATORIES CO., LTD.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A compound of formula (I), isomers thereof or pharmaceutically acceptable salts thereof,, wherein,
E1 and E2 are independently selected from single bond, —CH2— or —(CH2)2—;
L1 is selected from single bond, —(CH2)g—, —C(═O)— or —C(═O)—(CH2)h—;
m is 1 or 2;
n is 1 or 2;
g is 1, 2 or 3;
h is 1, 2 or 3;
R1 is selected from H, CN, C1-6 alkyl group or 3˜6-membered cycloalkyl group, wherein the above C1-6 alkyl group and 3˜6-membered cycloalkyl group are optionally substituted by 1, 2 or 3 Ra;
R2 is selected from H, F, Cl, Br, I or C1-3 alkyl groups, wherein the above C1-3 alkyl group is optionally substituted by 1, 2 or 3 Rb;
R3, R4 and R5 are independently selected from H, F, Cl, Br, I or C1-3 alkyl group, wherein the above C1-3 alkyl group is optionally substituted by 1, 2 or 3 Rc;
R6, R7 and R8 are independently selected from H, F, Cl, Br, I or C1-3 alkyl group, wherein the above C1-3 alkyl group is optionally substituted by 1, 2 or 3 Rd;
Each Ra is independently selected from H, F, Cl, Br, I, CN or C1-3 alkyl group, wherein the above C1-3 alkyl group is optionally substituted by 1, 2 or 3 R;
Each Rb is independently selected from F, Cl, Br or I;
Each Rc is independently selected from F, Cl, Br or I;
Each Rd is independently selected from F, Cl, Br or I;
Each R is independently selected from F, Cl, Br or I; and
wherein the isomers are selected from geometrical isomers, stereoisomers or tautomers.