Patent ID: 11896636
Assignee: GLAXOSMITHKLINE BIOLOGICALS SA
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A

Claim 0:
1. An immunogenic composition comprising:
(i) a first polypeptide antigen derived from the group consisting of a viral pathogen and a bacterial pathogen, and
(ii) a self-replicating RNA molecule encapsulated within a liposome, wherein said self-replicating RNA molecule cannot induce production of infectious viral particles, encodes a second polypeptide antigen from a viral pathogen, and can promote T cell-mediated immunity as well as humoral immunity to both first and second antigens,
wherein said first and second antigens are antigens from different pathogens,
wherein the self-replicating RNA molecule is not encapsulated in a virus-like particle; and
wherein the liposome encapsulating the self-replicating RNA molecule does not include capsid protein or envelope glycoproteins.