Patent ID: 11970521
Assignee: UNIVERSITY OF HAWAII
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 8:
9. A modified, neuroprotective β-amyloid peptide analogue of DAEFRHDSGYEVHHQ (SEQ ID NO. 2) for use in treating Alzheimer's Disease, wherein the peptide analogue comprises a sequence according to the following:, (SEQ ID NO. 3)

X1X2X3X4X5X6X7X8X9YX11X12HHX15, wherein Y and HH are preserved, wherein the X1-X9 residues are optionally present in the peptide analogue, wherein the X1-X9, X11-X12, and XD15 residues are each independently selected from natural and unnatural amino acids, wherein a backbone amide of at least one of the residues in the peptide analogue is N-methylated, wherein the peptide analogue ends at the X15 residue.