Patent ID: 11866465
Assignee: JUNO THERAPEUTICS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A multimerized oligomeric particle reagent that is in soluble form and comprises (i) an oligomer of between 1,500 and 7,500 tetramers of a streptavidin molecule or a streptavidin mutein molecule and (ii) a receptor-binding agent that binds to a receptor expressed on the surface of a target cell, wherein:
the receptor-binding agent comprises a streptavidin-binding peptide that is reversibly bound to one or more binding sites of the streptavidin or streptavidin mutein molecules of the oligomer; and
the receptor-binding agent is a stimulatory agent, wherein binding of the receptor-binding agent to the receptor induces a stimulatory signal in the target cell.