Patent ID: 11884741
Assignee: SYSMEX CORPORATION
Field: Biotechnology (Chemistry)
Classification: CPC C | IPC C

Claim 0:
1. A method for improving thermal stability of an antibody, comprising:
in a heavy chain of the antibody, changing at least one amino acid residue selected from the group consisting of 8th to 11th amino acid residues based on Kabat method to a cysteine residue, and changing at least one amino acid residue selected from the group consisting of 109th and 110th amino acid residues based on IMGT method to a cysteine residue,
wherein the modified antibody has improved thermal stability as compared to the unmodified antibody; and
wherein the modified antibody is Fab, Fab′, F(ab′)2, reduced IgG, IgG, IgA, IgM, IgD or IgE.