Patent ID: 11912794
Assignee: BICYCLERD LIMITED
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A peptide ligand specific for human kallikrein comprising a polypeptide comprising at least three cysteine residues, separated by at least two loop sequences, and a molecular scaffold which forms covalent bonds with the cysteine residues of the polypeptide such that at least two polypeptide loops are formed on the molecular scaffold, wherein the loops of the peptide ligand comprise five amino acids and a first loop comprises the motif GrxW/FPXK/RGr(SEQ ID NO: 209), a second loop comprises the motif GrxHXDLGr (SEQ ID NO: 210) and wherein the first Gr of the second loop is the second Gr of the first loop, wherein Gr represents cysteine and x represents any amino acid, and wherein R may optionally be replaced with N-methyl arginine, homoarginine or guanidylphenylalanine, and/or P may optionally be replaced with azetidine carboxylic acid.