Patent ID: 11884644
Assignee: SHANDONG JINCHENG PHARMACEUTICAL CHEMICAL CO., LTD.
Field: Organic fine chemistry (Chemistry)
Classification: CPC C  Y | IPC C

Claim 0:
1. A method for synthesizing a chiral intermediate (S)-4-amino-4-(3-pyridyl)-1-butanol for preparing (S)-nicotine, comprising:
performing a transamination reaction between 4-hydroxy-1-(3-pyridyl)-1-butanone and an amino donor to generate (S)-4-amino-4-(3-pyridyl)-1-butanol in catalysis of transaminase and coenzyme pyridoxal phosphate, the transaminase being one of transaminases with NCBI accession numbers being XP_007730450, 5FR9_A, WP_040602310 and XP_748821.