Patent ID: 11878989
Assignee: SHANGHAI FOREFRONT PHARMA CO., LTD.
Field: Organic fine chemistry (Chemistry)
Classification: CPC C  Y | IPC C

Claim 13:
14. The method for preparing the L-erythro biopterin compound according to claim 12, wherein the steps of the coupling reaction are as follows:
mix the compound represented by formula (VI), trans-1-propenyl boronic acid reagent, catalyst, solvent and ligand for reaction; after the reaction is completed, separate to obtain the compound represented by formula (IIb);
the trans-1-propenyl boronic acid reagent is selected from: trans-1-propenyl boronic acid pinacol ester, trans-1-propenyl boronic acid or trans-1-propenyl fluoroborate;
the catalyst is selected from one or more of the following reagents: 5% Pd/C, 10% Pd/C, Pd(OAc)2, PdCl2(PPh3)2, Pd(PPh3)4, PdCl2(dppf), PdCl2(MeCN)2 and Pd2(dba)3;
the solvent is selected from one or more of the following reagents: methanol, ethanol, isopropanol, butanol, water, tetrahydrofuran, 2-methyltetrahydrofuran, 1,4-dioxane, DME, DMF, DMSO, NMP, acetonitrile, dichloromethane, 1,2-dichloroethane, methyl acetate, ethyl acetate, isopropyl acetate, butyl acetate, ethyl ether, methyl tert-butyl ether, toluene, xylene, acetone, methyl ethyl ketone and methyl cyclopentane;
the ligands is selected from one or more of the following reagents: PPh3, BINAP, dppf, Xantphos, Xphos monophosphorus and diphosphorus ligands.