Patent ID: 11925680
Assignee: KORANEX CAPITAL
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 7:
8. A vaccine composition comprising a synthetic neoglycoconjugate and an adjuvant, wherein the synthetic neoglycoconjugate comprises one or more carbohydrate antigens (CA) conjugated to one or more amine groups of an amino acid of a carrier protein or peptide (CP-NH) via a linker, the synthetic neoglycoconjugate having the structure:, wherein p is an integer corresponding to the total number of carbohydrate antigens conjugated to the carrier protein or peptide at said one or more amine groups and p is 1 to 50,
wherein the one or more carbohydrate antigens comprises unsialylated TF antigen, and
wherein the carrier protein or peptide is, is from, or comprises Tetanus Toxoid, cross-reacting material 197, or an immunogenic fragment thereof; and
wherein administration of said vaccine composition triggers the production of antibodies against unsialylated TF antigen.