Patent ID: 11926631
Assignee: HEIDELBERG PHARMA RESEARCH GMBH
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A  Y | IPC A  C

Claim 1:
2. A method of treating cancer in a patient, the method comprising administering to the patient a pharmaceutical composition comprising a conjugate comprising:
(a) an amanitin derivative comprising a 6′-amino-substituted tryptophan moiety, which is selected from (i)S-desoxy-6′-amino-amanin, 6′-amino-amanin, (ii)S-desoxy-6′-amino-amanin-amide, 6′-amino-amaninamide, and (iii) a derivative of the amanitin derivative according to (i), wherein the free carboxylic acid moiety of amino acid 1 is converted to an carboxylic ester —C(═O)OR4 or to a moiety —C(═O)NH—OR4,
(b) a target-binding moiety, and
(c) optionally a linker linking said amanitin derivative and said target-binding moiety,
wherein the cancer is selected from the group consisting of breast cancer, pancreatic cancer, cholangiocarcinoma, colorectal cancer, prostate cancer, leukemia, and malignant lymphoma, and
wherein the cancer is responsive to inhibition of mammalian RNA polymerase II.