Patent ID: 11964017
Assignee: THE GENERAL HOSPITAL CORPORATION
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 9:
10. The method of claim 9, wherein the biocompatible ice slurry is configured to cool the one or more peripheral nerves by tissue cooling, wherein the tissue cooling comprises a first heat exchange stage, a second heat exchange stage, and a third heat exchange stage, wherein:
(i) the first heat exchange stage comprises reaching a local equilibrium temperature by rapid equilibration between the biocompatible ice slurry and the tissue, wherein at least some of the ice of the biocompatible ice slurry melts;
(ii) the second heat exchange stage comprises maintaining the local equilibrium temperature, wherein the remaining ice of the biocompatible ice slurry melts; and
(iii) the third heat exchange stage comprises gradually warming the tissue.