Patent ID: 11897970
Assignee: THE UNIVERSITY OF LIVERPOOL
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 10:
11. A process for the preparation of a compound of formula IA as defined in claim 1, which process comprises:
(i) deprotection of a compound of formula IA in which one or more hydroxyl groups are protected with an ether protecting group; in the presence of an acid;
(ii) deprotection of a compound of formula IA in which one or more primary amide groups are protected with a trityl group; in the presence of an acid;
(iii) reaction of a compound of formula XIIIA,, wherein AA2 to AA7 and are as defined in claim 1 and are optionally protected; and Z, R8, R9a, R10a, and R11a are as defined in claim 1, in a process comprising the steps of:
a) reacting the compound of formula XIIIA with a compound of formula XIV, wherein R1 is H, C1-6 alkyl, C1-6 acyl, benzyl or benzoyl or a delivery agent fragment of formula II to X, RAA1 is the side chain of the desired AA1 amino acid (optionally in protected form), and PG1 represents an optional suitable protecting group, and a suitable peptide coupling reagent; followed by
b) removal of the protecting group PG1 if present; or

(iv) reaction of a compound of formula XVA,, wherein AA1 to AA7 are as defined in claim 1 and are optionally protected, Z, R8, R9a, R10a, and R11a are as defined in claim 1, and R1 is H, C1-6 alkyl, C1-6 acyl, benzyl or benzoyl or a delivery agent fragment of formula II to X with a suitable peptide coupling agent.