Patent ID: 11932645
Assignee: BIAL—R&D INVESTMENTS, S.A.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A pharmaceutical composition, comprising a pharmaceutically acceptable carrier and a compound of Formula III:, or a pharmaceutically acceptable salt thereof, wherein:
R1 and R2 each represent independently for each occurrence hydrogen, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxyl, —(C1-4 alkylene)-(2-6 membered heteroalkyl), cyclopropyl, cyano, chloro, or fluoro;
R3 represents independently for each occurrence hydrogen or C1-4 alkyl;
X1 is one of the following:
(a) a carbonyl-containing linker selected from —C(O)N(H)-ψ and —C(O)N(H)(C1-6 alkylene)-ψ; where ψ is a bond to A1; or
(b) an amine-containing linker selected from —(C1-4 alkylene)-N(H)-ψ and —(C1-4 alkylene)-N(H)—(C1-4 alkylene)-ψ;

A1 is phenyl substituted by (a) 0, 1, 2, or 3 occurrences of Y2 and (b) one of the following:
(i) a 5-membered heteroaryl substituted by 0, 1, 2, or 3 occurrences of Y2; or
(ii) —(C1-6 alkylene)-CO2R3;

Y2 represents, independently for each occurrence, C1-6 alkyl, C3-6 cycloalkyl, halogen, C1-6 haloalkyl, C1-6 hydroxyalkyl, hydroxyl, C1-6 alkoxyl, cyano, azido, —N(R3)2, —(C1-6 alkylene)-(5-6 membered heterocyclyl), —(C1-6 alkylene)-CO2R3, or C1-6 haloalkyl-substituted C3-6 cycloalkyl; and
n is 1, 2, or 3.