Patent ID: 11860129
Assignee: ZOMEDICA BIOTECHNOLOGIES LLC
Field: Measurement (Instruments)
Classification: CPC G | IPC G

Claim 0:
1. A system for detecting an analyte in a sample, comprising:
a first bulk acoustic wave (BAW) resonator sensor comprising a surface to which a first recognition component is immobilized,
the first recognition component being configured to selectively bind: (a) the analyte, (b) an analyte molecule to which a tag is linked, (c) a tag, or (d) any combination thereof, to which an amplification element-linked recognition component is bound;

a second BAW resonator sensor comprising a surface to which a second recognition component is immobilized,
the second recognition component being configured to selectively bind: (a) the analyte, (b) an analyte molecule to which a tag is linked, (c) a tag, or (d) any combination thereof, to which an amplification element-linked recognition component is bound;

wherein the first recognition component has an affinity, capacity, or combination thereof for binding: (a) the analyte, (b) the analyte molecule to which the tag is linked, (c) the tag, or (d) any combination thereof, that is different from the affinity, capacity, or any combination thereof for binding: (a) the analyte, (b) the analyte molecule to which the tag is linked, (c) the tag, or (d) any combination thereof, of the second recognition component;
one or more containers housing an amplification element, a recognition component of the amplification element-linked recognition component, the tag, the analyte, or any combination thereof;
a fluid path from the one or more containers to the surface of both the first and second BAW resonator sensors to which the first and second recognition components are bound;
actuation circuitry configured to drive the first and second BAW resonator sensors in an oscillating motion;
measurement circuitry arranged to be coupled to both the first and second BAW resonator sensors and configured to measure one or more resonator output signals representing resonance characteristics of the oscillating motion of the low and high BAW resonator sensors; and
a controller operatively coupled with the actuation circuitry and the measurement circuitry.