Patent ID: 11939386
Assignee: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
Field: Pharmaceuticals (Chemistry)
Classification: CPC G  A  C | IPC A  C

Claim 2:
3. A CAR construct, wherein the scFv segment of the monoclonal antibody antigen binding region of the CAR construct is a binding region that specifically binds to AXL, and the scFv has a heavy chain variable region comprising the following three complementarity determining regions or CDRs:
CDR1 as shown in SEQ ID NO. 1,
CDR2 as shown in SEQ ID NO. 2, and
CDR3 as shown in SEQ ID NO. 3;
and a light chain variable region comprising the following three complementarity determining regions or CDRs:
CDR1′ as shown in SEQ ID NO. 4,
CDR2′ as shown in SEQ ID NO. 5, and
CDR3′ as shown in SEQ ID NO. 6;
or,
the scFv has a heavy chain variable region comprising the following three complementarity determining regions or CDRs:
CDR1 as shown in SEQ ID NO. 9,
CDR2 as shown in SEQ ID NO. 10, and
CDR3 as shown in SEQ ID NO. 11; and
a light chain variable region comprising the following three complementarity determining regions or CDRs:
CDR1′ as shown in SEQ ID NO. 12,
CDR2′ as shown in SEQ ID NO. 13, and
CDR3′ as shown in SEQ ID NO. 14;
or,
the scFv has a heavy chain variable region comprising the following three complementarity determining regions or CDRs:
CDR1 as shown in SEQ ID NO. 17,
CDR2 as shown in SEQ ID NO. 18, and
CDR3 as shown in SEQ ID NO. 19; and
a light chain variable region comprising the following three complementarity determining regions or CDRs:
CDR1′ as shown in SEQ ID NO. 20,
CDR2′ as shown in SEQ ID NO. 21, and
CDR3′ as shown in SEQ ID NO. 22.