Patent ID: 11964984
Assignee: CITY OF HOPE
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 7:
8. A method of treating diabetes or a cardiovascular disease, said method comprising administering to a subject in need thereof an effective amount of a compound, or a pharmaceutically acceptable salt thereof, having the formula:, , (II);
wherein
Ring A is C3-C8 cycloalkyl, 3 to 8 membered heterocycloalkyl, C6-C10 aryl, or 5 to 10 membered heteroaryl;
W1 is N or C(R4);
W2 is N or C(R5);
R4 is halogen, —CCl3, —CBr3, —CF3, —CI3, —CHCl2, —CHBr2, —CHF2, —CHI2, —CH2Cl, —CH2Br, —CH2F, —OCCl3, —OCF3, —OCBr3, —OCl3, —OCHCl2, —OCHBr2, —OCHF2, —OCH2Cl, —OCH2Br, —OCH2F, —CN, —OH, —NH2, —COOH, —CONH2, —NO2, —SH, —SeH, —SO3H, —OSO3H, —SO2NH2, —NHNH2, —ONH2, —NHC(O)NHNH2, —NHC(O)NH2, —NHSO2H, —NHC(O)H, —NHC(O)OH, —NHOH, —N3, —SF5, substituted or unsubstituted C1-C8 alkyl, unsubstituted 2 to 8 membered heteroalkyl, substituted or unsubstituted C3-C8 cycloalkyl, substituted or unsubstituted 3 to 8 membered heterocycloalkyl, substituted or unsubstituted C6-C10 aryl, or substituted or unsubstituted 5 to 10 membered heteroaryl;
R5 is hydrogen, halogen, —CCl3, —CBr3, —CF3, —CI3, —CHCl2, —CHBr2, —CHF2, —CHI2, —CH2Cl, —CH2Br, —CH2F, —CH2I, —OCCl3, —OCF3, —OCBr3, —OCI3, —OCHCl2, —OCHBr2, —OCHI2, —OCHF2, —OCH2Cl, —OCH2Br, —OCH2I, —OCH2F, —CN, —OH, —NH2, —COOH, —CONH2, —NO2, —SH, —SeH, —SO3H, —OSO3H, —SO2NH2, —NHNH2, —ONH2, —NHC(O)NHNH2, —NHC(O)NH2, —NHSO2H, —NHC(O)H, —NHC(O)OH, —NHOH, —N3, —SF5, substituted or unsubstituted C1-C8 alkyl, substituted or unsubstituted 2 to 8 membered heteroalkyl, substituted or unsubstituted C3-C8 cycloalkyl, substituted or unsubstituted 3 to 8 membered heterocycloalkyl, substituted or unsubstituted C6-C10 aryl, or substituted or unsubstituted 5 to 10 membered heteroaryl;
R6 is independently halogen, —CX63, —CHX62, —CH2X6, —OCX63, —OCHX62, —OCH2X6, —CN, —SOn6R6D, —SOv6NR6AR6B, —NR6CNR6AR6B, —ONR6AR6B, —NHC(O)NR6CNR6AR6B, —NHC(O)NR6AR6B, —N(O)m6, —NR6AR6B, —C(O)R6C, —C(O)OR6C, —C(O)NR6AR6B, —OR6D, —SR6D, —SeR6D, —NR6ASO2R6D, —NR6AC(O)R6C, —NR6AC(O)R6C, —NR6AOR6C, —SF5, —N3, substituted or unsubstituted C1-C8 alkyl, substituted or unsubstituted 2 to 8 membered heteroalkyl, substituted or unsubstituted C3-C8 cycloalkyl, substituted or unsubstituted 3 to 8 membered heterocycloalkyl, substituted or unsubstituted C6-C10 aryl, or substituted or unsubstituted 5 to 10 membered heteroaryl; two adjacent R6 substituents may optionally be joined to form a substituted or unsubstituted C3-C8 cycloalkyl, substituted or unsubstituted 3 to 8 membered heterocycloalkyl, substituted or unsubstituted C6-C10 aryl, or substituted or unsubstituted 5 to 10 membered heteroaryl;
R7 is independently halogen, oxo, —CX73, —CHX72, —CH2X7, —OCX73, —OCHX72, —OCH2X7, —CN, —SOn7R7D, —SOv7NR7AR7B, —NR7CNR7AR7B, —ONR7AR7B, —NHC(O)NR7CNR7AR7B, —NHC(O)NR7AR7B, —N(O)m7, —NR7AR7B, —C(O)R7C, —C(O)OR7C, —C(O)NR7AR7B, —OR7D, —SR7D, —SeR7D, —NR7ASO2R7D, —NR7AC(O)R7C, —NR7AC(O)OR7C, —NR7AOR7C, —SF5, —N3, substituted or unsubstituted C1-C8 alkyl, substituted or unsubstituted 2 to 8 membered heteroalkyl, substituted or unsubstituted C3-C8 cycloalkyl, substituted or unsubstituted 3 to 8 membered heterocycloalkyl, substituted or unsubstituted C6-C10 aryl, or substituted or unsubstituted 5 to 10 membered heteroaryl; two adjacent R7 substituents may optionally be joined to form a substituted or unsubstituted C3-C8 cycloalkyl, substituted or unsubstituted 3 to 8 membered heterocycloalkyl, substituted or unsubstituted C6-C10 aryl, or substituted or unsubstituted 5 to 10 membered heteroaryl; two R7 substituents bonded to the same carbon atom may optionally be joined to form a substituted or unsubstituted C3-C8 cycloalkyl, or substituted or unsubstituted 3 to 8 membered heterocycloalkyl;
R8 is independently halogen, oxo, —CX83, —CHX82, —CH2X8, —OCX83, —OCHX82, —OCH2X8, —CN, —SOn8R8D, —SOv8NR8AR8B, —NR8CNR8AR8B, —ONR8AR8B, —NHC(O)NR8CNR8AR8B, —NHC(O)NR8AR8B, —N(O)m8, —NR8AR8B, —C(O)R8C, —C(O)OR8C, —C(O)NR8AR8B, —OR8D, —SR8D, —SeR8D, —NR8ASO2R8D, —NR8AC(O)R8C, —NR8AC(O)OR8C, —NR8AOR8C, —SF5, —N3, substituted or unsubstituted C1-C8 alkyl, substituted or unsubstituted 2 to 8 membered heteroalkyl, substituted or unsubstituted C3-C8 cycloalkyl, substituted or unsubstituted 3 to 8 membered heterocycloalkyl, substituted or unsubstituted C6-C10 aryl, or substituted or unsubstituted 5 to 10 membered heteroaryl; two adjacent R8 substituents may optionally be joined to form a substituted or unsubstituted C3-C8 cycloalkyl, substituted or unsubstituted 3 to 8 membered heterocycloalkyl, substituted or unsubstituted C6-C10 aryl, or substituted or unsubstituted 5 to 10 membered heteroaryl;
R6A, R6B, R6C, R6D, R7A, R7B, R7C, R7D, R8A, R8B, R8C, and R8D are independently hydrogen, oxo, halogen, —CCl3, —CBr3, —CF3, —CI3, —CHCl2, —CHBr2, —CHF2, —CHI2, —CH2Cl, —CH2Br, —CH2F, —CH2I, —OCCl3, —OCF3, —OCBr3, —OCI3, —OCHCl2, —OCHBr2, —OCHI2, —OCHF2, —OCH2Cl, —OCH2Br, —OCH2I, —OCH2F, —CN, —OH, —NH2, —COOH, —CONH2, —NO2, —SH, —SeH, —SO3H, —OSO3H, —SO2NH2, —NHNH2, —ONH2, —NHC(O)NHNH2, —NHC(O)NH2, —NHSO2H, —NHC(O)H, —NHC(O)OH, —NHOH, —N3, —SF5, substituted or unsubstituted C1-C8 alkyl, substituted or unsubstituted 2 to 8 membered heteroalkyl, substituted or unsubstituted C3-C8 cycloalkyl, substituted or unsubstituted 3 to 8 membered heterocycloalkyl, substituted or unsubstituted C6-C10 aryl, substituted or unsubstituted 5 to 10 membered heteroaryl; R6A and R6B substituents bonded to the same nitrogen atom may optionally be joined to form a substituted or unsubstituted 3 to 8 membered heterocycloalkyl or substituted or unsubstituted 5 to 10 membered heteroaryl; R7A and R7B substituents bonded to the same nitrogen atom may optionally be joined to form a substituted or unsubstituted 3 to 8 membered heterocycloalkyl or substituted or unsubstituted 5 to 10 membered heteroaryl; R8A and R8B substituents bonded to the same nitrogen atom may optionally be joined to form a substituted or unsubstituted 3 to 8 membered heterocycloalkyl or substituted or unsubstituted 5 to 10 membered heteroaryl;
X6, X7, and X8 are independently —F, —Cl, —Br, or —I;
n6, n7, and n8 are independently an integer from 0 to 4;
m6, m7, m8, v6, v7, and v8 are independently 1 or 2;
z6 is an integer from 0 to 3;
z7 is an integer from 0 to 9; and
z8 is an integer from 0 to 7;
wherein each substituted C1-C8 alkyl, substituted 2 to 8 membered heteroalkyl, substituted C3-C8 cycloalkyl, substituted 3 to 8 membered heterocycloalkyl, substituted C6-C10 aryl, and substituted 5 to 10 membered heteroaryl is independently substituted with at least one substituent group.