Patent ID: 11857807
Assignee: INSIGHTEC LTD.
Field: Medical technology (Instruments)
Classification: CPC A | IPC A

Claim 0:
1. A system for treating a target blood-brain barrier (BBB) region within a tissue region of interest, the system comprising:
an ultrasound transducer;
a processor; and
memory storing (i) a sonication parameter for applying at least one sequence of sonications to the target BBB region using the ultrasound transducer, (ii) a microbubble characteristic for microbubbles selected to be administered into the target BBB region, and (iii) instructions which, when executed by the processor, cause the processor to:
(a) electronically simulate treatment in accordance with the sonication parameter and the microbubble characteristic at least in part by computationally executing the at least one sequence of sonications and computationally administering the microbubbles having the microbubble characteristic;
(b) computationally predict a degree of tissue disruption of the target BBB region resulting from the treatment based on the simulation thereof;
(c) computationally generate a treatment protocol specifying the sonication parameter and the microbubble characteristic based at least in part on the predicted degree of tissue disruption; and
(d) activate the ultrasound transducer in accordance with the treatment protocol.