Patent ID: 11945812
Assignee: VANDERBILT UNIVERSITY
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 28:
29. The compound or salt according to claim 1, wherein
E is, Q1 is selected from the group consisting of —CH2—, —C(═O)—, —C(═O)N(RG1)—, —C(═O)O—, —S(═O)2—, —S(═O)2N(RG1)— and —C(═NRH1)—;
each RG1 is independently selected from the group consisting of hydrogen, C1-6alkyl, C1-6haloalkyl and hydroxy-C1-6alkyl;
each RH1 is independently selected from the group consisting of hydrogen, —OH, C1-6alkoxy, —CN and C1-6alkyl;
RD is selected from the group consisting of hydrogen, C3-7cycloalkyl, phenyl, halogen, —CN, C1-6alkoxy, —C(═O)O—C1-6alkyl and C1-6alkyl optionally substituted with one or more, identical or different substituent(s) selected from the group consisting of phenyl, 3-11 membered heterocyclyl, C1-6alkoxy, halogen, —OH, —N(C1-6alkyl)2, —C(═O)OH, —C(═O)O—C1-6alkyl, —C(═O)NH(C1-6alkyl), —NHC(═O)—C1-6alkyl, —OC(═O)—C1-6alkyl and phenyl-C1-6alkoxy;
RE and RF is each independently selected from the group consisting of Ra2 and Rb2;
Ra2 is selected from the group consisting of hydrogen, C1-6alkyl, C1-6haloalkyl, C3-10cycloalkyl, 3-11 membered heterocyclyl, C6-10aryl and 5-10 membered heteroaryl, wherein the C1-6alkyl, C1-6haloalkyl, C3-10cycloalkyl, 3-11 membered heterocyclyl, C6-10aryl and 5-10 membered heteroaryl are all optionally substituted with one or more, identical or different Rb2 and/or Rc2;
each Rb2 is independently selected from the group consisting of —ORc2, —NRc2Rc2, halogen, —CN, —C(═O)ORc2, —C(═O)NRc2Rc2, —NHC(═O)Rc2, —N(C1-4alkyl)C(═O)Rc2, —NHC(═O)ORc2 and —N(C1-4alkyl)C(═O)ORc2;
each Rc2 is independently selected from the group consisting of hydrogen, C1-6alkyl, C1-6haloalkyl, 3-11 membered heterocyclyl, C6-10aryl and 5-10 membered heteroaryl, to wherein the C1-6alkyl, C1-6haloalkyl, 3-11 membered heterocyclyl, C6-10aryl and 5-10 membered heteroaryl are all optionally substituted with one or more, identical or different substituent(s) selected from the group consisting of C1-6alkyl, C1-6alkoxy, halogen, —OH, —C(═O)OH, —C(═O)O—C1-6alkyl, —C(═O)C1-6alkyl, —C(═O)NH2, —C(═O)NH(C1-6alkyl), —C(═O)N(C1-6alkyl)2, and the bivalent substituent ═O.