Patent ID: 11859168
Assignee: CHRISTOPHER B. REID
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 25:
26. The method of claim 1, wherein the vector:
targets a sequence with at least 70% identity to a viral genomic nucleotide sequence or its complement; comprises synthetic oligonucleotide sequences that reduce the ability of target cells to sustain HIV replication by >70;
comprises synthetic oligonucleotide sequences that reduce HIV viral activity by >70%; and/or
comprises one or more synthetic nucleotide sequence comprising SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7, SEQ ID NO: 8, the nucleotides at positions 12-26 of SEQ ID NO: 8 SEQ ID NO: 9, SEQ ID NO: 10, SEQ ID NO: 11, SEQ ID NO: 12, SEQ ID NO: 13, SEQ ID NO: 14, SEQ ID NO: 15, SEQ ID NO: 16, and/or SEQ ID NO: 17; or
wherein the vector comprises a polycistronic expression cassette, a transcriptional promoter element, and multiple nucleic acid coding sequences operably linked to a transcriptional promoter element.