Patent ID: 11859006
Assignee: DAIICHI SANKYO COMPANY, LIMITED
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A  G | IPC A  C

Claim 14:
15. The method of claim 1, wherein the disease is selected from ectopic ossification, fibrodysplasia ossificans progressiva (FOP), and diffuse intrinsic pontine glioma (DIPG); the active mutation in ALK2 comprises at least one mutation selected from L196P, delP197_F198insL, R202I, R206H, Q207E, R258S, R258G, G325A, G328E, G328R, G328W, G356D, and R375P; and wherein the antibody or the antigen-binding fragment thereof comprises a heavy chain variable region comprising a CDRH1, a CDRH2, and a CDRH3, which comprise the amino acid sequences of:
SEQ ID NO: 5, SEQ ID NO: 6, and SEQ ID NO: 7, respectively,
SEQ ID NO: 11, SEQ ID NO: 12, and SEQ ID NO: 13, respectively,
SEQ ID NO: 18, SEQ ID NO: 19, and SEQ ID NO: 20, respectively, or
SEQ ID NO: 24, SEQ ID NO: 25, and SEQ ID NO: 26, respectively; and
a light chain variable region comprising a CDRL1, a CDRL2, and a CDRL3, which comprise the amino acid sequences of:
SEQ ID NO: 8, SEQ ID NO: 9, and SEQ ID NO: 10, respectively,
SEQ ID NO: 8, SEQ ID NO: 17, and SEQ ID NO: 10, respectively,
SEQ ID NO: 14, SEQ ID NO: 15, and SEQ ID NO: 16, respectively,
SEQ ID NO: 21, SEQ ID NO: 22, and SEQ ID NO: 23, respectively, or
SEQ ID NO: 27, SEQ ID NO: 28, and SEQ ID NO: 29, respectively.