Patent ID: 11898171
Assignee: LYSENTECH CO., LTD.
Field: Biotechnology (Chemistry)
Classification: CPC C | IPC C

Claim 1:
2. A method of increasing the production of a lytic bacteriophage comprising incubating a host bacterium and the lytic bacteriophage that specifically infect the host bacterium in the presence of sublethal concentration of ROS for the host bacteria, whereby the production of bacteriophage is increased by increasing burst size of the bacteriophage, wherein the host bacterium is Escherichia coli and the bacteriophage that infects E. coli is bacteriophage T4; wherein the ROS is H202, wherein the incubation is done in a liquid or a solid medium, wherein the sublethal dose of ROS is 0.2 mM for the incubation in the solid medium, and the sublethal dose of ROS is 4.5 mM for the incubation in the liquid medium.