Patent ID: 11945869
Assignee: INHIBRX, INC.
Field: Biotechnology (Chemistry)
Classification: CPC C | IPC C

Claim 0:
1. A method of stimulating or inducing an immune response in a subject, the method comprising administering, to a subject in need thereof, a PD-1-binding polypeptide construct, comprising at least one heavy chain only variable domain (PD-1 VHH domain) that specifically binds PD-1, wherein the at least one PD-1 VHH domain comprises a CDR1, CDR2 and CDR3 comprising:
the amino acid sequences set forth in SEQ ID NOS: 268, 278, and 283, respectively;
the amino acid sequences set forth in SEQ ID NOS: 272, 278, and 283, respectively; or
the amino acid sequences set forth in SEQ ID NOS: 273, 278, and 283, respectively.