Patent ID: 11891605
Assignee: UNIVERSITY OF SOUTHAMPTON
Field: Biotechnology (Chemistry)
Classification: CPC A  C | IPC C

Claim 0:
1. A method of making a polynucleic acid for inducing processing of a partially processed mRNA transcript to facilitate removal of a retained intron to produce a fully processed mRNA transcript that encodes a functional form of a protein, the method comprising:
synthesizing the polynucleic acid, wherein the polynucleic acid is from about 10 to about 50 nucleotides in length and comprises a sequence that is complementary to at least 10 contiguous bases of a wild-type target sequence of the partially processed mRNA transcript, wherein the partially processed mRNA transcript is capable of encoding the functional form of a protein and comprises at least one retained intron, wherein the polynucleic acid induces splicing out of the retained intron from the partially processed mRNA transcript.