Patent ID: 11872249
Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 30:
31. The method of claim 25, wherein the second CAR that binds a B-cell antigen binds CD22 and comprises:
(i) a HCDR1, HCDR2, HCDR3, LCDR1, LCDR2, and LCDR3 comprising:
(a) SEQ ID NOs: 719, 720, 721, 730, 731, and 732, respectively;
(b) SEQ ID NOs: 722, 723, 724, 733, 734, and 735, respectively;
(c) SEQ ID NOs: 725, 726, 727, 736, 737, and 738, respectively; or
(d) SEQ ID NOs: 1036, 1037, 1038, 1039, 1040, and 1041, respectively;

(ii) a light chain variable region (VL) and a heavy chain variable region (VH), wherein:
(a) the VL comprises the amino acid sequence of SEQ ID NO: 840 or 739;
(b) the VH comprises the amino acid sequence of SEQ ID NO: 839 or 728; or
(c) the VL and VH comprise:
(a) SEQ ID NOs: 840 and 839, respectively; or
(b) SEQ ID NOs: 739 and 728, respectively;

(iii) a scFv comprising the amino acid sequence of SEQ ID NO: 742, 835, 836, or 837; or
(iv) the amino acid sequence of SEQ ID NO: 744.