Patent ID: 11858981
Assignee: NOVARTIS AG
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. An immunobinder comprising:
(i) a light chain variable domain comprising human light chain framework sequences that are at least 85% identical to the light chain framework sequences of SEQ ID NO: 2; and
(ii) a heavy chain variable domain comprising human heavy chain framework sequences that are at least 85% identical to the heavy chain framework sequences of SEQ ID NO: 4 and comprises a threonine (T) at position 24 according to AHo numbering;, wherein the CDR1, CDR2, and CDR3 polypeptide sequences of the light chain variable domain of (i) are substituted with the light chain CDR1, CDR2, and CDR3 from a donor rabbit immunobinder and the CDR1, CDR2, and CDR3 polypeptide sequences of the heavy chain variable domain of (ii) are substituted with the heavy chain CDR1, CDR2, and CDR3 from a donor rabbit immunobinder.