Patent ID: 11905320
Assignee: CUE BIOPHARMA, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C  G | IPC A  C  G

Claim 0:
1. A fusion polypeptide comprising:
a) a variant IL-2 polypeptide, wherein the variant IL-2 polypeptide comprises up to five amino acid substitutions relative to the amino acid sequence set forth in SEQ ID NO:1, and wherein amino acid 16 is Glu and amino acid 42 is Ala; and
b) an antibody Fc region,
wherein the fusion polypeptide does not comprise a major histocompatibility complex (MHC) polypeptide, and
wherein the fusion polypeptide comprises from 300 to 700 amino acids.