Patent ID: 11952469
Assignee: NATIONAL TAIWAN UNIVERSITY OF SCIENCE AND TECHNOLOGY
Field: Medical technology (Instruments)
Classification: CPC C  A | IPC A  C

Claim 11:
12. A hydrogel composition with thermos-sensitive and ionic reversible properties, comprising:
a thermos-sensitive polymer; and
an anionic polymer comprising polysaccharide having at least one carboxylic acid, wherein the thermos-sensitive polymer and the anionic polymer are mixed at a temperature over a lower critical solution temperature (LCST);
wherein the hydrogel composition is analyzed by Raman spectroscopy when the hydrogel composition is in a gel state, a Raman mapping image of the hydrogel composition presents an ordered structure, and the hydrogel composition can reversibly transfers from the gel state to a solution state;
wherein the hydrogel composition is analyzed by small-angle X-ray scattering (SAXS) when the hydrogel composition is in the gel state, the hydrogel composition comprises a scattering intensity peak,
wherein a weight ratio of the thermos-sensitive polymer and the anionic polymer is 1:0.02-0.12,
wherein when the hydrogel composition contacts a metal chelate aqueous solution having a temperature lower than the LCST of the hydrogel composition, the hydrogel composition transfers from a gel state to a solution state.