Patent ID: 11859177
Assignee: WILLIAM MARSH RICE UNIVERSITY
Field: Measurement (Instruments)
Classification: CPC A  C  G  Y | IPC A  C  G

Claim 0:
1. A system comprising:
a tunable pulsed laser;
an optical fiber probe configured to deliver a laser pulse from the tunable pulsed laser, wherein the optical fiber probe is further configured to receive optical scattering signals, wherein the laser pulse comprises a pulse duration of 70 picoseconds to about 14 nanoseconds, a wavelength of from about 400 nanometers to about 1200 nanometers, and a pulse fluence from about 20 mJ/cm2 to about 250 mJ/cm2;
an optical detector for detecting said optical scattering signals;
a computer operatively connected to the optical detector to process the optical signals received therefrom, wherein the computer is further operatively connected to the tunable pulsed laser; and
wherein the computer is configured to control pulse duration, wavelength, and pulse fluence of the tunable pulsed laser; and
wherein the computer is configured to determine the presence of at least one hemozoin nanocrystal based on the optical signals received from the optical detector following a laser pulse from the tunable pulsed laser by generating a time-resolved optical scattering image, wherein the at least one hemozoin nanocrystal is present if the time-resolved optical scattering image depicts a change in photodetector signal of at least 0.10 V for at least 10 ns.