Patent ID: 11931411
Assignee: ASSISTANCE PUBLIQUE HOPITAUX DE PARIS
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 0:
1. A method for epicutaneous desensitization of a subject allergic to an allergen, the method comprising:
a) epicutaneously exposing the subject to the allergen and generating an immune reaction in the subject by applying a dose of the allergen, without an adjuvant, onto an intact region of skin of the subject; and
b) repeatedly applying the allergen, without an adjuvant, to an intact region of the skin of the subject, at a dose, frequency or for an application time adapted to sustain the immune reaction, the exposure and sustained reaction leading to desensitization of the subject;
wherein the allergen is applied by a cutaneous occlusive device configured to ensure contact between the allergen and the region of skin, and wherein said dose of allergen is comprised between 0.1 and 1,000 μg/cm2 of a surface area of the device.