Patent ID: 11911415
Assignee: EDITAS MEDICINE, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C  G | IPC A  C  G

Claim 2:
3. The method of claim 2, wherein the second gRNA molecule targets a gene selected from the group consisting of HBB, BCL11a, HBA1, HBA2, ATRX, RPS19, FANCA, FANCB, FANCC, FANCD1, FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ, FANCL, FANCM, FANCN, FANCP, RAD51C, PKLR, IFNG, SEC23B, ANK1, SPTB, SPTA, SLC4A1, EPB42, EPO, CSF2, CSF3, VWF, F7, F8, F9, F2, F5, F7, F10, F11, F12, F13A1, F13B, PROC, PROS1, SERPINC1, FGA, FGB, FGG, PROZ, PLG, PLAT, PLAU, F3, TFPI, PAI, HCF2, IDUA, IDS, GALNS, ARSB, SGSH, NAGLU, HGSNAT, GALNS, IL2RG, ADA, IL7R, CD247, RAG1, RAG2, DCLRE1C, PTPRC, JAK3, RMRP, FOXP3, STAT1, ICOS, TNFRSF13B, CD19, TNFRSF13C, CD20, CD81, CCR5, CXCR4, RFX5, RFX5, RFXAP, MHC2TA, RFXB, TAP1, TAP2, TAPBP, VPS45, HAX1, ELANE, NCF1, CYBB, CYBA, NCF2, NCF4, PRF1, HPLH, WAS, LYST, AK2, BTK, TNFSF5, AICDA, CD40, UNG, GBA, MPL, MAN2B1, LIPA, GYS2, G6PC, G6PT1/SLC37A4, GAA, AGL, GBE1, PYGM, PYGL, PFKM, PHKA2, PHKB, PGAM2, GH1, TG, INS, GCG, FXN, LCAT, APOA1, IGF1, AGA, UOX, IDUA, IDS, GALNS, ARSB, SGSH, NAGLU, ARSA, ABCD1, GLA, HPRT, ADA, GALC, ASAH1, PPT1, TPP1, NPC1, NPC2, SMPD1, SMPD1, JAK2, TET2, EPOR, EPOR, PIGA, C5, C3, IL6, IL1A, IL1B, IL2, IL3, IL7, IL9, IL12, IL17, IL18, IL4, IL10, IL11, IL35, IL26, IL13, IL23, IL27, IFNG, CXCL1, CXCL2, CXCL3, CXCL4, CXCL5, CXCL6, CXCL7, CXCL8, CXCL9, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL15, CXCL16, CCL1, CCL2, CCL3, CCL4, CCL5, CCL6, CCL7, CCL8, CCL9, CCL10, CCL11, CCL12, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, XCL1, XCL2, CX3CL1, CXCR1, CXCR2, CXCR3, CXCR4, CXCR5, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCR10, CCR11, CX3CR1, DARC, C1INH, EGF, VEGF, IFNA1, IFNA2, IFNB1, TNF, ABL1, BCL2, BCL11A, BCL11B, BCR, BMI1, BRD2, CCND1, CCND2, CDX2, ETV6, JAK2, JUND, KLF6, LCK, LMO1, LMO2, LYL1, MLL, MLLT10, MTCP1, MYC, NFKB2, NOTCH1, NUP98, OLIG2, PBX1, PICALM, RAP1GDS1, RUNX1, STIL, TAL1, TAL2, NKAIN2, TCF3, TCL1A, TLX1, TLX3, FAS, BID, CD152, PCDCD1, CBLB, PTPN6, CD19, PARP1, CD223, CD272, CD200R1, TIGIT, LAIR1, PTGER2, PTGER4, CD16, PDCD1, HAVCR2, CD40, WAS, WT1, and CHK1.