Patent ID: 11884656
Assignee: SENTINEL ONCOLOGY LIMITED
Field: Organic fine chemistry (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 13:
14. A method according to claim 1 wherein the compound is selected from
3-[5-(4-bromophenyl)-1-[2-(trifluoromethyl)phenyl]pyrrol-2-yl]benzoic acid;
3-[5-(4-bromophenyl)-1-[2-(trifluoromethyl)phenyl]pyrrol-2-yl]-N-[2-(dimethylamino) ethyl]benzamide;
N-[2-(dimethylamino)ethyl]-3-[5-phenyl-1-[2-(trifluoromethyl) phenyl]pyrrol-2-yl]benzamide;
3-[5-(4-bromophenyl)-1-[4-chloro-2-(trifluoromethyl)phenyl] pyrrol-2-yl]-N-[2-(dimethylamino) ethyl]benzamide;
N-[2-(dimethylamino)ethyl]-3-[5-(4-fluorophenyl)-1-[2-(trifluoromethyl) phenyl]pyrrol-2-yl]benzamide;
3-[5-(4-bromophenyl)-1-[4-(trifluoromethyl)-3-pyridyl]pyrrol-2-yl]-N-[2-(dimethylamino)ethyl]benzamide;
1-[3-[5-(4-bromophenyl)-1-[2-(trifluoromethyl)phenyl]pyrrol-2-yl]phenyl]-N,N-dimethyl-methanamine;
4-[5-(4-bromophenyl)-1-[2-(trifluoromethyl)phenyl]pyrrol-2-yl]-N-[2-(dimethylamino)ethyl] benzamide;
3-[5-(4-bromophenyl)-1-[2-(trifluoromethyl)phenyl]pyrrol-2-yl]-N-[(1-methyl-4-piperidyl)methyl] benzamide;
3-[5-(4-bromophenyl)-1-[2-(trifluoromethyl)phenyl]pyrrol-2-yl]-N-(1-methyl-4-piperidyl)benzamide;
3-[5-(4-bromophenyl)-1-[2-(trifluoromethyl)phenyl]pyrrol-2-yl]-N-[2-(dimethylamino)ethyl]-N-methyl-benzamide;
3-[5-(4-bromophenyl)-1-[2-(trifluoromethyl)phenyl]pyrrol-2-yl]-N-[(3R)-1-methylpyrrolidin-3-yl]benzamide;
3-[5-(4-bromophenyl)-1-[2-(trifluoromethyl)phenyl]pyrrol-2-yl]-N-[(3 S)-1-methylpyrrolidin-3-yl]benzamide;
3-[5-(4-bromophenyl)-1-[2-(trifluoromethyl)phenyl]pyrrol-2-yl]-4-chloro-N-[2-(dimethylamino)-ethyl]benzamide;
N-[3-[5-(4-bromophenyl)-1-[2-(trifluoromethyl)phenyl]pyrrol-2-yl]phenyl]-N′,N′-dimethyl-propane-1,3-diamine;
3-[3-[5-(4-bromophenyl)-1-[2-(trifluoromethyl)phenyl]pyrrol-2-yl]phenoxy]-N,N-dimethyl-propan-1-amine;
N-[[3-[5-(4-bromophenyl)-1-[2-(trifluoromethyl)phenyl]pyrrol-2-yl]phenyl]methyl]-N′,N′-dimethyl-ethane-1,2-diamine;
N-[[3-[5-(4-bromophenyl)-1-[2-(trifluoromethyl)phenyl]pyrrol-2-yl]phenyl]methyl]-2-(dimethylamino)acetamide;
N-[2-(dimethylamino)ethyl]-3-[5-(4-isopropylphenyl)-1-[2-(trifluoromethyl)phenyl]pyrrol-2-yl]benzamide;
3-[5-(4-bromophenyl)-1-[2-(trifluoromethyl)phenyl]pyrrol-2-yl]-N-[2-(methylamino)ethyl] benzamide;
3-[5-(4-bromophenyl)-1-[2-(trifluoromethyl)phenyl]pyrrol-2-yl]-N-[3-(dimethylamino)propyl] benzamide;
3-[5-(4-bromophenyl)-1-(2-hydroxyphenyl)pyrrol-2-yl]-N-[2-(dimethyl amino)ethyl]benzamide;
N-[2-(dimethylamino)ethyl]-4-[5-phenyl-1-[2-(trifluoromethyl) phenyl]pyrrol-2-yl]benzamide;
4-[5-(4-bromophenyl)-1-[2-(trifluoromethyl)phenyl]pyrrol-2-yl]benzoic acid
5-[5-(4-bromophenyl)-1-[2-(trifluoromethyl)phenyl]pyrrol-2-yl]-N-[2-(dimethylamino)ethyl] pyridine-2-carboxamide;
6-[5-(4-bromophenyl)-1-[2-(trifluoromethyl)phenyl]pyrrol-2-yl]-N-[2-(dimethylamino)ethyl] pyridine-3-carboxamide;
6-[5-(4-bromophenyl)-1-[2-(trifluoromethyl)phenyl]pyrrol-2-yl]pyridine-3-carboxylic acid;
4-[5-(4-bromophenyl)-1-[2-(trifluoromethyl)phenyl]pyrrol-2-yl]-N-[3-(dimethylamino)propyl]-2-methoxy-benzamide;
4-[5-(4-bromophenyl)-1-[2-(trifluoromethyl)phenyl]pyrrol-2-yl]-N-[2-(dimethylamino)ethyl]-3-methoxy-benzamide;
4-[5-(4-chlorophenyl)-1-[2-(trifluoromethyl)phenyl]pyrrol-2-yl]-N-[2-(dimethylamino)ethyl] benzamide;
4-[5-(4-bromophenyl)-1-[2-(trifluoromethyl)phenyl]pyrrol-2-yl]-N-[3-(dimethylamino)propyl] benzamide;
3-[4-[5-(4-bromophenyl)-1-[2-(trifluoromethyl)phenyl]pyrrol-2-yl]phenoxy]-N,N-dimethyl-propan-1-amine;
4-[5-(4-bromophenyl)-1-[2-(trifluoromethyl)phenyl]pyrrol-2-yl]-3-chloro-N-[2-(dimethylamino) ethyl]benzamide;
3-chloro-N-[2-(dimethyl amino) ethyl]-4-[5-phenyl-1-[2-(trifluoromethyl)phenyl]pyrrol-2-yl]benzamide;
4-[5-(4-bromophenyl)-1-[2-(trifluoromethyl)phenyl]pyrrol-2-yl]-2-chloro-N-[2-(dimethylamino)ethyl]benzamide;
2-chloro-N-[2-(dimethyl amino) ethyl]-4-[5-phenyl-1-[2-(trifluoromethyl)phenyl]pyrrol-2-yl]benzamide;
4-[5-(4-bromophenyl)-1-[4-(trifluoromethyl)-3-pyridyl]pyrrol-2-yl]-N-[2-(dimethylamino)ethyl] benzamide;
N-[2-(dimethylamino)ethyl]-4-[5-(6-fluoro-3-pyridyl)-1-[2-(trifluoromethyl)phenyl]pyrrol-2-yl]benzamide;
4-[5-(2,4-difluorophenyl)-1-[2-(trifluoromethyl)phenyl]pyrrol-2-yl]-N-[2-(dimethylamino)ethyl] benzamide;
4-[5-(4-bromophenyl)-1-[2-(trifluoromethyl)phenyl]pyrrol-2-yl]-N-[2-(dimethylamino)ethyl]-benzenesulfonamide;
2-[[4-[5-(4-bromophenyl)-1-[2-(trifluoromethyl)phenyl]pyrrol-2-yl]phenyl]methoxy]-N,N-dimethyl-ethanamine;
N-[5-[5-(4-bromophenyl)-1-[2-(trifluoromethyl)phenyl]pyrrol-2-yl]phenyl]-3-(dimethylamino) propanamide;
2-[4-[5-(4-bromophenyl)-1-[2-(trifluoromethyl)phenyl]pyrrol-2-yl]phenyl]acetic acid;
1-[[4-[5-(4-bromophenyl)-1-[2-(trifluoromethyl)phenyl]pyrrol-2-yl]phenyl]methyl]-4-methyl-piperazine;
4-[5-(4-chlorophenyl)-1-[4-(trifluoromethyl)-3-pyridyl]pyrrol-2-yl]-N-[2-(dimethylamino)ethyl]-benzamide;
4-[5-(4-bromophenyl)-1-[2-(methoxymethyl)phenyl]pyrrol-2-yl]-N-[2-(dimethylamino)ethyl] benzamide;
4-[5-(4-chlorophenyl)-1-[4-(trifluoromethyl)-3-pyridyl]pyrrol-2-yl]-N-[3-(dimethylamino)-propyl]benzamide;
3-[5-(4-bromophenyl)-1-[2-(trifluoromethyl)phenyl]pyrrol-2-yl]-N-[2-(dimethylamino)ethyl]-4-methoxy-benzamide;
5-[5-(4-bromophenyl)-1-[2-(trifluoromethyl)phenyl]pyrrol-2-yl]-N-[2-(dimethylamino)ethyl]-2-methoxy-benzamide;
[3-[5-(4-bromophenyl)-1-[2-(trifluoromethyl)phenyl]pyrrol-2-yl]phenyl]-[(3R)-3-(dimethylamino) pyrrolidin-1-yl]methanone;
[3-[5-(4-bromophenyl)-1-[2-(trifluoromethyl)phenyl]pyrrol-2-yl]phenyl]-[(3S)-3-(dimethylamino) pyrrolidin-1-yl]methanone;
4-[5-(4-cyanophenyl)-1-[2-(trifluoromethyl)phenyl]pyrrol-2-yl]-N-[2-(dimethylamino)ethyl] benzamide;
4-[5-(4-chlorophenyl)-1-[2-(trifluoromethyl)phenyl]pyrrol-2-yl]-N-[3-(dimethylamino)propyl] benzamide;
N-[2-(dimethylamino)ethyl]-4-[5-(4-fluorophenyl)-1-[2-(trifluoromethyl) phenyl]pyrrol-2-yl]benzamide;
N-[3-(dimethylamino)propyl]-4-[5-(4-fluorophenyl)-1-[2-(trifluoromethyl)phenyl]pyrrol-2-yl]benzamide;
6-[5-(4-chlorophenyl)-1-[2-(trifluoromethyl)phenyl]pyrrol-2-yl]-N-[2-(dimethylamino)ethyl]pyridine-3-carboxamide;
6-[5-(4-chlorophenyl)-1-[2-(trifluoromethyl)phenyl]pyrrol-2-yl]-N-[3-(dimethylamino)propyl]-pyridine-3-carboxamide;
4-[5-(4-chlorophenyl)-1-[5-isobutyl-2-(trifluoromethyl)phenyl]pyrrol-2-yl]-N-[2-(dimethylamino)ethyl]-benzamide;
4-[5-(4-chlorophenyl)-1-isobutyl-2-(trifluoromethyl)phenyl]pyrrol-2-yl]-N-[3-(dimethylamino)propyl]-benzamide;
4-[5-(4-bromophenyl)-1-[2-(trifluoromethyl)phenyl]pyrrol-2-yl]benzenesulfonamide;
4-[5-(6-cyano-3-pyridyl)-1-[2-(trifluoromethyl)phenyl]pyrrol-2-yl]-N-[2-(dimethylamino)ethyl]-benzamide;
3-chloro-N-[2-(dimethylamino)-ethyl]-4-[5-phenyl-1-[4-(trifluoromethyl)-3-pyridyl]pyrrol-2-yl]benzamide;
3-chloro-N-[3-(dimethylamino)-propyl]-4-[5-phenyl-1-[4-(trifluoromethyl)-3-pyridyl]pyrrol-2-yl]benzamide;
6-[5-(4-chlorophenyl)-1-[4-(trifluoromethyl)-3-pyridyl]pyrrol-2-yl]-N-[2-(dimethylamino)ethyl]-pyridine-3-carboxamide;
4-[5-(4-chlorophenyl)-1-[2-(trifluoromethyl)phenyl]pyrrol-2-yl]-N-[(3R)-1-methylpyrrolidin-3-yl]benzamide;
4-[5-(4-chlorophenyl)-1-[2-(trifluoromethyl)phenyl]pyrrol-2-yl]-N-[(3S)-1-methylpyrrolidin-3-yl]benzamide;
4-[5-(3-chlorophenyl)-1-[2-(trifluoromethyl)phenyl]pyrrol-2-yl]-N-[2-(dimethylamino)ethyl]-benzamide;
4-[5-(4-chlorophenyl)-1-[4-(trifluoromethyl)-3-pyridyl]pyrrol-2-yl]-N-[2-(dimethylamino)ethyl]-3-methoxy-benzamide;
4-[5-(4-chlorophenyl)-1-[4-(trifluoromethyl)-3-pyridyl]pyrrol-2-yl]-N-[3-(dimethylamino)propyl]-3-methoxy-benzamide;
4-[5-(5-chloro-2-pyridyl)-1-[2-(trifluoromethyl)phenyl]pyrrol-2-yl]-N-[2-(dimethylamino)ethyl]-benzamide;
4-[5-(5-chloro-2-pyridyl)-1-[2-(trifluoromethyl)phenyl]pyrrol-2-yl]-N-[3-(dimethylamino)propyl]-benzamide;
4-[5-(4-chlorophenyl)-1-[3-(trifluoromethyl)phenyl]pyrrol-2-yl]-N-[2-(dimethylamino)ethyl]-benzamide;
4-[5-(4-chlorophenyl)-1-[3-(trifluoromethyl)phenyl]pyrrol-2-yl]-N-[3-(dimethylamino)propyl]-benzamide;
4-[5-(4-chlorophenyl)-1-(trifluoromethyl)-2-pyridyl]pyrrol-2-yl]-N-[2-(dimethylamino)ethyl]-benzamide;
4-[5-(4-chlorophenyl)-1-[3(trifluoromethyl)-2-pyridyl]pyrrol-2-yl]-N-[3-(dimethylamino)propyl]-benzamide;
4-[5-(4-chlorophenyl)-1-[4-(trifluoromethyl)-3-pyridyl]pyrrol-2-yl]-N-(2-morpholinoethyl)-benzamide;
4-[4-(4-(4-chlorophenyl)-5-[2-(trifluoromethyl)phenyl]pyrazol-1-yl]-N-[2-(dimethylamino)ethyl]-benzamide;
4-[5-(4-chlorophenyl)-1-[2-(trifluoromethyl)phenyl]pyrrol-2-yl]-N-[2-(dimethylamino)ethyl]-N-methyl-benzamide;
[4-[5-(4-chlorophenyl)-1-[2-(trifluoromethyl)phenyl]pyrrol-2-yl]phenyl]-piperazin-1-yl-methanone;
[4-[5-(4-chlorophenyl)-1-[2-(trifluoromethyl)phenyl]pyrrol-2-yl]phenyl]-(4-methylpiperazin-1-yl)methanone;
4-[5-(4-chlorophenyl)-1-[2-(trifluoromethyl)phenyl]pyrrol-2-yl]-N-(2-methoxyethyl)benzamide;
4-[5-(4-chlorophenyl)-1-[2-(trifluoromethyl)phenyl]pyrrol-2-yl]-N-(2-piperazin-1-ylethyl)benzamide;
4-[5-(4-chlorophenyl)-1-[2-(trifluoromethyl)phenyl]pyrrol-2-yl]-N-[2-(4-methylpiperazin-1-yl)ethyl]benzamide;
4-[5-(4-chlorophenyl)-1-[4-(trifluoromethyl)-3-pyridyl]pyrrol-2-yl]-N-[2-(dimethylamino)ethyl]-3-fluoro-benzamide;
1-[4-[5-(4-chlorophenyl)-1-[2-(trifluoromethyl)phenyl]pyrrol-2-yl]phenyl]-3-[2-(dimethylamino)-ethyl]urea;
2-[4-[5-(4-chlorophenyl)-1-[2-(trifluoromethyl)phenyl]pyrrol-2-yl]phenyl]-N-[2-(dimethylamino)-ethyl]acetamide;
4-[3-(4-chlorophenyl)-4-[2-(trifluoromethyl)phenyl]isoxazol-5-yl]-N-[2-(dimethylamino)ethyl]-benzamide;
4-[3-(4-chlorophenyl)-4-[2-(trifluoromethyl)phenyl]-1H-pyrazol-5-yl]-N-[2-(dimethylamino)ethyl] benzamide;
N-(2-aminoethyl)-4-[5-(4-chlorophenyl)-1-[2-(trifluoromethyl)-phenyl]pyrrol-2-yl]benzamide;
4-[5-(4-chlorophenyl)-1-[2-(trifluoromethyl)phenyl]pyrrol-2-yl]-N-(2-morpholinoethyl)benzamide;
4-[5-(4-chlorophenyl)-1-[4-fluoro-2-(trifluoromethyl)phenyl]pyrrol-2-yl]-N-[2-(dimethylamino)ethyl]-benzamide;
4-[5-(4-chlorophenyl)-1-[4-chloro-2-(trifluoromethyl)phenyl]pyrrol-2-yl]-N-[2-(dimethylamino)ethyl]-benzamide;
5-[5-(4-chlorophenyl)-1-[2-(trifluoromethyl)phenyl]pyrrol-2-yl]-N-[2-(dimethylamino)ethyl]-thiophene-2-carboxamide;
2-[4-[5-(4-chlorophenyl)-1-[2-(trifluoromethyl)phenyl]pyrrol-2-yl]phenyl]-N-(2-morpholinoethyl)-acetamide;
2-[4-[5-(4-chlorophenyl)-1-[2-(trifluoromethyl)phenyl]pyrrol-2-yl]phenyl]-N-(2-piperazin-1-ylethyl)acetamide;
[3-[5-(4-bromophenyl)-1-[2-(trifluoromethyl)phenyl]pyrrol-2-yl]phenyl]-[4-(3-pyridylmethyl)-1-piperidyl]methanone;
4-[4-(4-chlorophenyl)-5-[2-(trifluoromethyl)phenyl]pyrazol-1-yl]-N-(2-morpholinoethyl)-benzamide;
4-[4-(4-chlorophenyl)-5-[2-(trifluoromethyl)phenyl]pyrazol-1-yl]-N-[3-(dimethylamino)propyl]-benzamide;
N-[2-(dimethylamino)ethyl]-4-[4-(4-fluorophenyl)-5-[2-(trifluoromethyl)phenyl]pyrazol-1-yl]benzamide;
2-[4-[5-(4-chlorophenyl)-1-[2-(trifluoromethyl)phenyl]pyrrol-2-yl]phenyl]-N-[2-(dimethylamino)ethyl]-2-methyl-propanamide;
4-[5-(4-chlorophenyl)-1-(4-trifluoromethyl-3-pyridyl)pyrrol-2-yl]-N-[2-[[(3S)-tetrahydrofuran-3-yl]amino]ethyl]-benzamide;
4-[5-(4-chlorophenyl)-1-[2-(trifluoromethyl)phenyl]pyrrol-2-yl]-N-[(2S)-2-(dimethylamino)propyl]benzamide,
or a pharmaceutically acceptable salt or tautomer thereof.