Patent ID: 11939381
Assignee: ELI LILLY AND COMPANY
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 5:
6. A process for producing an antibody comprising cultivating a mammalian cell capable of expressing the antibody and recovering the antibody; wherein the antibody comprises a first and second heavy chain and a first and second light chain, wherein each chain comprises a variable region and a constant region, and wherein:
a) the first heavy chain of the antibody comprises a CDR1 having the amino acid sequence of SEQ ID NO:1, a CDR2 having the amino acid sequence of SEQ ID NO:2, and a CDR3 having the amino acid sequence of SEQ ID NO:3;
b) the first light chain of the antibody comprises a CDR1 having the amino acid sequence of SEQ ID NO:7, a CDR2 having the amino acid sequence of SEQ ID NO:8, and a CDR3 having the amino acid sequence of SEQ ID NO:9;
c) the second heavy chain of the antibody comprises a CDR1 having the amino acid sequence of SEQ ID NO:13, a CDR2 having the amino acid sequence of SEQ ID NO:14, and a CDR3 having the amino acid sequence of SEQ ID NO:15; and
d) the second light chain of the antibody comprises a CDR1 having the amino acid sequence of SEQ ID NO:19, a CDR2 having the amino acid sequence of SEQ ID NO:20, and a CDR3 having the amino acid sequence of SEQ ID NO:21; optionally, wherein the first heavy chain of the antibody forms at least one disulfide bond with the first light chain of the antibody, the second heavy chain of the antibody forms at least one disulfide bond with the second light chain of the antibody, and the first heavy chain of the antibody forms at least one disulfide bond with the second heavy chain of the antibody.