Patent ID: 11931465
Assignee: CHILDREN'S NATIONAL MEDICAL CENTER
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A

Claim 0:
1. A combined immunotherapeutic and photothermal method for treating a subject having a neoplasm, tumor, or cancer comprising:
treating the subject with an immunotherapy that comprises administering a checkpoint inhibitor which is an anti-CTLA-4 checkpoint inhibitor and/or an anti-PD-1/PD-L1 checkpoint inhibitor and wherein the checkpoint inhibitor is selected from the group consisting of ipilimumab, nivolumab, pembrolizumab and atezolizumab,
administering intratumorally Prussian blue nanoparticles comprising Prussian blue nanoparticles coated with first and second polymer coatings having opposite charges to each other; and
photothermally treating the subject; wherein the neoplasm, tumor or cancer is neuroblastoma; and wherein the first and second polymer coatings comprise polyallylamine hydrochloride and poly(acrylic acid).