Patent ID: 11971467
Assignee: CASE WESTERN RESERVE UNIVERSITY
Field: Measurement (Instruments)
Classification: CPC G  A | IPC A  G

Claim 10:
11. A system for generating quantitative maps for a region of interest in a subject, the system comprising:
a pilot tone (PT) radiofrequency (RF) signal source configured to generate a PT RF signal; and
a magnetic resonance imaging (MRI) system comprising:
a magnet system configured to generate a polarizing magnetic field about at least a portion of a subject;
a magnetic gradient system including a plurality of magnetic gradient coils configured to apply at least one magnetic gradient field to the polarizing magnetic field;
a radio frequency (RF) system configured to apply an RF field to the subject and to receive magnetic resonance signals from the subject using a coil array; and
a computer system programmed to:
acquire MRF data from a region of interest in a subject using the MRI system, wherein the MRF data is acquired using a free-breathing MRF pulse sequence;
acquire PT navigator signals based on the applied PT RF signal using the MRI system, wherein the PT navigator signals are associated with a plurality of respiratory states and wherein the PT navigator signals are encoded with the acquired MRF data
generate one or more images for each of the plurality of respiratory states based on the MRF data and the PT navigator signals;
for each respiratory state, compare the one or more images for the respiratory state to a respiratory state MRF dictionary associated with the respiratory state to determine at least one tissue property of the MRF data associated with the respiratory state; and
generate at least one quantitative parameter map for the at least one tissue property for each respiratory state.