Patent ID: 11918682
Assignee: LABORATORIOS FARMACÉUTICOS ROVI, S.A.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 14:
15. An injectable composition consisting of
about 25% wt of drug, which is letrozole, wherein the drug has a particle size distribution selected from any of the following <10% of the particles are less than 20 microns, <10% of the particles are greater than 350 microns, and a d0.5 between 70-200 microns; or d0.1 of 38.21 microns, d0.5 of 141.35 microns, and d0.9 of 312.13 microns; and
the remaining balance of said injectable composition consisting of polymeric solution consisting of 57-60% wt of DMSO; and 40-43% wt of biodegradable poly(lactic acid) polymer (PLA), wherein
the polymeric solution has a viscosity in the range of 0.8-1.5 Pas, as measured at 25° C.;
the drug is suspended in the polymeric solution;
the PLA has been irradiated with beta-radiation; and
the PLA is end-capped with an ester group.