Patent ID: 11932691
Assignee: FRED HUTCHINSON CANCER CENTER
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A  G | IPC C  G

Claim 18:
19. A method for:
(a) identifying the presence of a receptor tyrosine kinase-like orphan receptor 1 (ROR1) protein in a tissue sample, comprising contacting a tissue sample with a binding protein, wherein the binding protein comprises an antibody or a binding fragment thereof comprising:
(1) a heavy chain comprising CDR sequences set forth as SEQ ID NOs.:21, 25, and 29 and a light chain comprising CDR sequences set forth as SEQ ID NOs.:31, 33, and 35;
(2) a heavy chain comprising CDR sequences set forth as SEQ ID NOs.:22, 26, and 29 and a light chain comprising CDR sequences set forth as SEQ ID NOs.:31, 33, and 35;
(3) a heavy chain comprising CDR sequences set forth as SEQ ID NOs.:23, 27, and 29 and a light chain comprising CDR sequences as set forth as SEQ ID NOs.:31, 33, and 35; or
(4) a heavy chain comprising CDR sequences set forth as SEQ ID NOs.:24, 28, and 30 and a light chain comprising CDR sequences set forth as SEQ ID NOs.:32, 34, and 36; and

(b) detecting specific binding of the binding protein to the tissue, thereby identifying tissue that expresses the ROR1 protein.