Patent ID: 11952419
Assignee: UNIVERSITY OF CONNECTICUT
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 9:
10. A method for treating colon cancer or a melanoma, comprising administering to a subject in need thereof an antibody that selectively binds to an extracellular domain (ECD) of human CD300c, in an amount effective to treat the colon cancer or melanoma, wherein the antibody comprises each of the following complementarity determining regions (CDRs):
Heavy chain CDR1 (H-CDR1) comprising the amino acid sequence IYGMN (SEQ ID NO: 10);
Heavy chain CDR2 (H-CDR2) comprising the amino acid sequence WINTYT (SEQ ID NO: 11);
Heavy chain CDR3 (H-CDR3) comprising the amino acid sequence ARSRFAY (SEQ ID NO: 12);
Light chain CDR1 (L-CDR1) comprising the amino acid sequence KASQNVGTNVA (SEQ ID NO: 13);
Light chain CDR2 (L-CDR2) comprising the amino acid sequence SASYRYS (SEQ ID NO:14); and
Light chain CDR3 (L-CDR3) comprising the amino acid sequence QQYNSYPLT (SEQ ID NO:15).