Patent ID: 11965016
Assignee: MINTECH-V, LLC
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A hybrid organic-inorganic system comprising:
hierarchically-ordered fluorapatite crystalline structures,
wherein the hierarchically-ordered fluorapatite crystalline structures comprise prism-shaped microstructures, and
a protein scaffold membrane capable of growing the hierarchically-ordered fluorapatite crystalline structures thereon or therein,
wherein the protein scaffold membrane comprises a polypeptide comprising an amino acid sequence of MESLLP-[(((VPGIG)2VPGKG(VPGIG)2)2-DDDEEKFLRRIGRFG-(VPGIG)2VPGKG(VPGIG)2)2]3-V,
wherein the protein scaffold membrane comprises an elastin-like polypeptide membrane having an aggregated macromolecular arrangement comprising random coil conformations and one or more of β-sheet or β-spiral conformations, wherein the aggregated macromolecular arrangement controls a formation of the hierarchically-ordered fluorapatite crystalline structures, and wherein at least a portion of the hierarchically-ordered fluorapatite crystalline structures comprise two or more of nanostructures, microstructures, or macrostructures assembled in a hierarchical order across multiple length-scales and exhibit a spherulitic radial geometry.