Patent ID: 11872225
Assignee: AGIOS PHARMACEUTICALS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 16:
17. The method of claim 1, wherein the compound is of Formula (II′):, , or a pharmaceutically acceptable salt thereof, wherein:
Ra and Rb are each independently hydrogen, halogen, —CN, —NO2, —N3, optionally substituted alkyl, —ORo3, —N(Rn1)2, —C(═O)N(Rn1)2, or —C(═O)Rc2, or Ra and Rb can be taken together with the carbon atom to form optionally substituted cycloalkyl or optionally substituted heterocyclyl;
each instance of Rn1 is independently hydrogen, optionally substituted —C1-C6 alkyl, or a nitrogen protecting group;
each instance of Ro3 is independently hydrogen, optionally substituted —C1-C6 alkyl, or an oxygen protecting group:, each instance of Rc2 is independently optionally substituted —C1-C6 alkyl:
each instance of Rj and Rk is independently selected from H, halogen, —CN, —ORo7, —N(Rn5)2, —N(Rn5)C(═O)Rc5, —C(═O)N(Rn5)2, —C(═O)Rc5, —C(═O)ORo7, —SRjs, —S(═O)2Rjs, or —S(═O)Rjs, optionally substituted —C1-C6 alkyl; or Rj and Rk can be taken together with the carbon atom to form C═O, C═NRjn, an optionally substituted C3-C6 monocyclic cycloalkyl ring or an optionally substituted C3-C6 monocyclic heterocyclyl ring;
each of Rn5 and Rjn is independently hydrogen, optionally substituted —C1-C6 alkyl, —ORo8, or a nitrogen protecting group;
each instance of Ro7 is independently hydrogen, optionally substituted —C1-C6 alkyl, or an oxygen protecting group;
each instance of Rc5 is independently optionally substituted —C1-C6 alkyl;
each instance of Rjs is independently optionally substituted —C1-C6 alkyl, optionally substituted C6-12 aryl, optionally substituted heteroaryl, or a sulfur protecting group;
each instance of RP is independently selected from hydrogen, halogen, —CN, —NO2, —N3, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted heterocyclyl, optionally substituted heteroaryl, —ORo6, —SRs2, —N(Rn3)2, —C(═O)N(Rn3)2, —N(Rn3)C(═O)Rc4, —C(═O)R4, —C(═O)ORo6, —OC(═O)Ro4, —S(═O)Rs2, —S(═O)2Rs2, —S(═O)ORo6, —OS(═O)Ro4, —S(═O)2ORo6, —OS(═O)2Ro4, —S(═O)N(Rn3)2, —S(═O)2N(Rn3)2, —N(Rn3)S(═O)Rs2, —N(Rn3)S(═O)2Rs2, —N(Rn3)C(═O)ORo6, —OC(═O)N(Rn3)2, —N(Rn3)C(═O)N(Rn3)2, —N(Rn3)S(═O)N(Rn3)2, —N(Rn3)S(═O)2N(Rn3)2, —N(Rn3)S(═O)ORo6, —N(Rn3)S(═O)2ORo6, —OS(═O)N(Rn3)2, —OS(═O)2N(Rn3)2, or two instances of RP attached to the same or adjacent carbon atoms, taken together with the atoms to which they are attached form an optionally substituted cycloalkyl or a heterocycloalkyl;
each instance of Rn3, Rnc, and Rnd is independently hydrogen, optionally substituted —C1-C6 alkyl, or a nitrogen protecting group;
each instance of Ro6 is independently hydrogen, optionally substituted —C1-C6 alkyl, or an oxygen protecting group;
each instance of Rc4 is independently optionally substituted —C1-C6 alkyl;
each instance of Rs2 is independently optionally substituted —C1-C6 alkyl, or a sulfur protecting group; and
q is 0, 1, 2, or 3.