Patent ID: 11867693
Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Field: Measurement (Instruments)
Classification: CPC G  B | IPC B  G

Claim 14:
15. A method of determining the presence of a cerebrospinal fluid (CSF) leak in a subject, said method comprising:
applying a nasal drip sample obtained from said subject to the sample application zone of a device of claim 5, wherein said nasal drip sample is diluted 300-fold in a buffer;
operating said device in a lateral-flow assay format and detecting a signal if present at test lines T1 and T2 in a device comprising two test lines and at test lines T1, T2, and T3 in a device comprising three test lines; and
where there is no detectable signal at any test line or a detectable signal at only at test line T1, identifying the subject as a subject having no CSF leak;
where the device comprises two test lines and there is a detectable signal at both test lines T1 and T2 identifying the subject as having a CSF leak;
where the device comprises three test lines and there is a detectable signal at all three test lines T1, T2, and T3, identifying the subject as having a CSF leak; and

where the device comprises three test lines and there is a detectable signal only two test lines T1 and T2, identify the subject as possibly, but not definitely, having a CSF leak and requiring further follow up.