Patent ID: 11919923
Assignee: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
Field: Organic fine chemistry (Chemistry)
Classification: CPC C  A  Y | IPC A  C

Claim 9:
10. A method for (a) inhibiting replication of a virus, or (b) treating or preventing, or alleviating a disease caused by a virus infection, wherein the method comprises
administrating a safe and effective amount of an active ingredient, or a formulation containing the active ingredient, or a pharmaceutical composition comprising the active ingredient and pharmaceutically acceptable carriers;
wherein: the active ingredient is a compound of formula (I) or a pharmaceutically acceptable salts thereof,, wherein:
R1 is cyano;
R2 is OR3 or C1-6alkoxy;
R3 is selected from the group consisting of hydrogen, C1-20alkanoyl, and aminoC1-20alkanoyl,
R4 is hydrogen;
R5 is C1-20alkanoyl, or aminoC1-20alkanoyl;
R6 is amino;
R7 is hydrogen;
R8 is selected from the group consisting of hydrogen, deuterium, and halogen; and
X is CH2— or CD2-;
and
the virus is selected from the group consisting of:
(1) coronavirus infecting human;
(2) human respiratory syncytial virus (RSV);
(3) flaviviridae virus that is selected from dengue virus (DENV), Zika virus (Zika); and
(4) coronavirus infecting porcine that is porcine epidemic diarrhea virus (PEDV).