Patent ID: 11865108
Assignee: WOCKHARDT LIMITED
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 1:
2. The compound according to claim 1, selected from:
(2S,5R)—N-{[(2S,4R)-4-Methyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2S,4S)-4-Methyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2R,4S)-4-Methyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2R,4R)-4-Methyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2S,4R)-4-Hydroxymethyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
2S,5R)—N-{[(2S,4S)-4-Hydroxymethy-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2R,4S)-4-Hydroxymethyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2R,4R)-4-Hydroxymethy-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2S,4R)-4-Aminomethyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1, 6-diazabicyclo[3.2.1]octane-2-carboxamide trifluoroacetate salt;
(2S,5R)—N-{[(2S,4S)-4-Aminomethyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1, 6-diazabicyclo[3.2.1]octane-2-carboxamide trifluoroacetate salt;
(2S,5R)—N-{[(2R,4S)-4-Aminomethyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1, 6-diazabicyclo[3.2.1]octane-2-carboxamide trifluoroacetate salt;
(2S,5R)—N-{[(2R,4R)-4-Aminomethyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1, 6-diazabicyclo[3.2.1]octane-2-carboxamide trifluoroacetate salt;
(2S,5R)—N-{[(2S,4R)-4-Cyanomethyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
2S,5R)—N-{[(2S,4S)-4-Cyanomethy-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2R,4S)-4-Cyanomethyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2R,4R)-4-Cyanomethyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2S,4R)-4-Fluoromethyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2S,4S)-4-Fluoromethyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2R,4S)-4-Fluoromethyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2R,4R)-4-Fluoromethyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2S,4R)-4-Chloromethyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2S,4S)-4-Chloromethyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2R,4S)-4-Chloromethyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2R,4R)-4-Chloromethyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2S,4S)-4-Mercaptomethyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2S,4R)-4-Mercaptomethyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2R,4S)-4-Mercaptomethyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2R,4R)-4-Mercaptomethyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2S,4R)-4-(Aziridin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2S,4R)-4-(Aziridin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2R,4S)-4-(Aziridin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2R,4R)-4-(Aziridin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2S,4R)-4-(Azetidin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2S,4S)-4-(Azetidin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2R,4S)-4-(Azetidin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2R,4R)-4-(Azetidin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2S,4R)-4-(Pyrrolidin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2S,4S)-4-(Pyrrolidin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2R,4S)-4-(Pyrrolidin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2R,4R)-4-(Pyrrolidin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2S,4R)-4-(Piperidin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2S,4S)-4-(Piperidin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2R,4S)-4-(Piperidin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2R,4R)-4-(Piperidin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2S,4R)-4-(Azepan-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2S,4S)-4-(Azepan-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2R,4S)-4-(Azepan-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2R,4R)-4-(Azepan-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2S,4R)-4-(Piperazin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2S,4S)-4-(Piperazin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2R,4S)-4-(Piperazin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2R,4R)-4-(Piperazin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2S,4R)-4-(Morpholin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2S,4S)-4-(Morpholin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2R,4S)-4-(Morpholin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2R,4R)-4-(Morpholin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2S,4R)-4-(Thiomorpholin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2S,4S)-4-(Thiomorpholin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2R,4S)-4-(Thiomorpholin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2R,4R)-4-(Thiomorpholin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2S,4R)-4-(1H-Pyrrol-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2S,4S)-4-(1H-Pyrrol-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2R,4S)-4-(1H-Pyrrol-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2R,4R)-4-(1H-Pyrrol-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2S,4R)-4-(1H-imidazol-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2S,4S)-4-(1H-imidazol-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2R,4S)-4-(1H-imidazol-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2R,4R)-4-(1H-imidazol-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2S,4R)-4-(1H-pyrazol-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2S,4S)-4-(1H-pyrazol-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2R,4S)-4-(1H-pyrazol-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2R,4R)-4-(1H-pyrazol-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2S,4R)-4-(1H-1,2,3-triazol-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2S,4S)-4-(1H-1,2,3-triazol-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2R,4S)-4-(1H-1,2,3-triazol-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2R,4R)-4-(1H-1,2,3-triazol-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2S,4R)-4-(1H-1,2,4-triazol-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2S,4S)-4-(1H-1,2,4-triazol-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2R,4S)-4-(1H-1,2,4-triazol-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2R,4R)-4-(1H-1,2,4,triazol-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2S,4R)-4-(1H-tetrazol-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2S,4S)-4-(1H-tetrazol-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2R,4S)-4-(1H-tetrazol-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2R,4R)-4-(1H-tetrazol-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2S,4R)-4-(2H-tetrazoyl-2-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2S,4S)-4-(2H-tetrazol-2-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2R,4S)-4-(2H-tetrazol-2-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2R,4R)-4-(2H-tetrazol-2-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2S,4S)-4-Carbamimidomethyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2S,4R)-4-Carbamimidomethyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2R,4S)-4-Carbamimidomethyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
(2S,5R)—N-{[(2R,4R)-4-Carbamimidomethyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
or a stereoisomer or a pharmaceutically acceptable salt thereof.