Patent ID: 11884730
Assignee: CASE WESTERN RESERVE UNIVERSITY
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A method of inhibiting Interferon-y (IFN-y) induced Programmed Death-Ligand 1 (PD-L1) expression in medulloblastoma or rhabdomyosarcoma cancer cells of a subject, the method comprising:
detecting the expression level of Cdk5 in the medulloblastoma or rhabdomyosarcoma cancer cells prior to administration of the Cdk5 inhibitor;
comparing the detected expression level of Cdk5 to a threshold level; and
administering to IFN-y induced PD-L1 overexpressing cancer cells of the subject an amount of a CdK5 inhibitor effective to suppress immune checkpoint PD-L1 expression in the medulloblastoma or rhabdomyosarcoma cancer cells and to enhance an immune response to the medulloblastoma or rhabdomyosarcoma cancer cells if the detected expression level of Cdk5 exceeds the threshold level.