Patent ID: 11939340
Assignee: PRELUDE THERAPEUTICS INCORPORATED
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 14:
15. The compound of claim 1 that is:
8a-(Hydroxymethyl)-2-(2-((1-(methylsulfonyl)piperidin-4-yl)amino)-5-(trifluoromethyl) pyrimidin-4-yl)-6,7,8,8a-tetrahydro-4H-thieno[2,3-a]pyrrolizin-4-one;
8a-(Fluoromethyl)-2-(2-((1-(methylsulfonyl)piperidin-4-yl)amino)-5-(trifluoromethyl) pyrimidin-4-yl)-6,7,8,8a-tetrahydro-4H-thieno[2,3-a]pyrrolizin-4-one;
8a-(2-Fluoroethyl)-2-(2-((1-(methylsulfonyl)piperidin-4-yl)amino)-5-(trifluoromethyl) pyrimidin-4-yl)-6,7,8,8a-tetrahydro-4H-thieno[2,3-a]pyrrolizin-4-one;
8a-Methyl-2-(2-((1-(methylsulfonyl)piperidin-4-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)-6,7,8,8a-tetrahydro-4H-thieno[2,3-a]pyrrolizin-4-one;
2-(2-((1-(Methylsulfonyl)piperidin-4-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)-6,7,8,8a-tetrahydro-4H-thieno[2,3-a]pyrrolizin-4-one;
8a-Cyclopropyl-2-(2-((1-(methylsulfonyl)piperidin-4-yl)amino)-5-(trifluoromethyl) pyrimidin-4-yl)-6,7,8,8a-tetrahydro-4H-thieno[2,3-a]pyrrolizin-4-one;
8a-Cyclobutyl-2-(2-((1-(methylsulfonyl)piperidin-4-yl)amino)-5-(trifluoromethyl) pyrimidin-4-yl)-6,7,8,8a-tetrahydro-4H-thieno[2,3-a]pyrrolizin-4-one;
8a-(3,3-Difluorocyclobutyl)-2-(2-((1-(methylsulfonyl)piperidin-4-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)-6,7,8,8a-tetrahydro-4H-thieno[2,3-a]pyrrolizin-4-one;
8a-(3-Hydroxycyclobutyl)-2-(2-((1-(methylsulfonyl)piperidin-4-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)-6,7,8,8a-tetrahydro-4H-thieno[2,3-a]pyrrolizin-4-one;
8a-(3-Fluorocyclobutyl)-2-(2-((1-(methylsulfonyl)piperidin-4-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)-6,7,8,8a-tetrahydro-4H-thieno[2,3-a]pyrrolizin-4-one;
2-(5-Chloro-2-((1-(methylsulfonyl)piperidin-4-yl)amino)pyrimidin-4-yl)-8a-ethyl-6,7,8,8a-tetrahydro-4H-thieno[2,3-a]pyrrolizin-4-one;
8a-Ethyl-2-(2-((1-(methylsulfonyl)piperidin-4-yl)amino)pyrimidin-4-yl)-6,7,8,8a-tetrahydro-4H-thieno[2,3-a]pyrrolizin-4-one;
7-Hydroxy-8a-isopropyl-2-(2-((1-(methylsulfonyl)piperidin-4-yl)amino)-5-(trifluoromethyl) pyrimidin-4-yl)-6,7,8,8a-tetrahydro-4H-thieno[2,3-a]pyrrolizin-4-one;
8a-Isopropyl-7-methoxy-2-(2-((1-(methylsulfonyl)piperidin-4-yl)amino)-5-(trifluoromethyl) pyrimidin-4-yl)-6,7,8,8a-tetrahydro-4H-thieno[2,3-a]pyrrolizin-4-one;
7-(Hydroxymethyl)-8a-isopropyl-2-(2-((1-(methylsulfonyl)piperidin-4-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)-6,7,8,8a-tetrahydro-4H-thieno[2,3-a]pyrrolizin-4-one;
8a-Ethyl-7,7-difluoro-2-(2-((1-(methylsulfonyl)piperidin-4-yl)amino)-5-(trifluoromethyl) pyrimidin-4-yl)-6,7,8,8a-tetrahydro-4H-thieno[2,3-a]pyrrolizin-4-one;
8a-Ethyl-7-hydroxy-2-(2-((1-(methylsulfonyl)piperidin-4-yl)amino)-5-(trifluoromethyl) pyrimidin-4-yl)-6,7,8,8a-tetrahydro-4H-thieno[2,3-a]pyrrolizin-4-one;
8a-Ethyl-7-hydroxy-7-methyl-2-(2-((1-(methylsulfonyl)piperidin-4-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)-6,7,8,8a-tetrahydro-4H-thieno[2,3-a]pyrrolizin-4-one;
8a-Ethyl-7,7-difluoro-2-(2-((1-((1-methyl-1H-pyrazol-4-yl)sulfonyl)piperidin-4-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)-6,7,8,8a-tetrahydro-4H-thieno[2,3-a]pyrrolizin-4-one;
8a-Ethyl-7-hydroxy-2-(2-((1-((1-methyl-1H-pyrazol-4-yl)sulfonyl)piperidin-4-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)-6,7,8,8a-tetrahydro-4H-thieno[2,3-a]pyrrolizin-4-one;
8a-Ethyl-2-(2-((1-((1-methyl-1H-pyrazol-4-yl)sulfonyl)piperidin-4-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)-6,7,8,8a-tetrahydro-4H-thieno[2,3-a]pyrrolizin-4-one;
8a-Ethyl-7-(methylamino)-2-(2-((1-(methylsulfonyl)piperidin-4-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)-6,7,8,8a-tetrahydro-4H-thieno[2,3-a]pyrrolizin-4-one;
7-(Dimethylamino)-8a-ethyl-2-(2-((1-(methylsulfonyl)piperidin-4-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)-6,7,8,8a-tetrahydro-4H-thieno[2,3-a]pyrrolizin-4-one;
7-Amino-8a-ethyl-2-(2-((1-(methylsulfonyl)piperidin-4-yl)amino)-5-(trifluoromethyl) pyrimidin-4-yl)-6,7,8,8a-tetrahydro-4H-thieno[2,3-a]pyrrolizin-4-one;
8a-Ethyl-7-(ethylamino)-2-(2-((1-(methylsulfonyl)piperidin-4-yl)amino)-5-(trifluoromethyl) pyrimidin-4-yl)-6,7,8,8a-tetrahydro-4H-thieno[2,3-a]pyrrolizin-4-one;
8a-Ethyl-7-((methyl-d3)amino)-2-(2-((1-(methylsulfonyl)piperidin-4-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)-6,7,8,8a-tetrahydro-4H-thieno[2,3-a]pyrrolizin-4-one;
8a-Ethyl-2-(2-(((3R,4S)-3-methyl-1-(methylsulfonyl)piperidin-4-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)-7-(methylamino)-6,7,8,8a-tetrahydro-4H-thieno[2,3-a]pyrrolizin-4-one;
8a-Ethyl-2-(2-(((3R,4S)-3-methyl-1-((1-methyl-1H-pyrazol-4-yl)sulfonyl)piperidin-4-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)-7-(methylamino)-6,7,8,8a-tetrahydro-4H-thieno[2,3-a]pyrrolizin-4-one;
7-Amino-8a-ethyl-2-(2-(((3R,4S)-3-methyl-1-(methylsulfonyl)piperidin-4-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)-6,7,8,8a-tetrahydro-4H-thieno[2,3-a]pyrrolizin-4-one;
7-Amino-8a-ethyl-2-(2-(((3R,4S)-3-methyl-1-((1-methyl-1H-pyrazol-4-yl)sulfonyl) piperidin-4-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)-6,7,8,8a-tetrahydro-4H-thieno[2,3-a]pyrrolizin-4-one;
8a-Ethyl-2-(2-(((3R,4R)-3-fluoro-1-(methylsulfonyl)piperidin-4-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)-7-(methylamino)-6,7,8,8a-tetrahydro-4H-thieno[2,3-a]pyrrolizin-4-one;
8a-Ethyl-2-(2-(((3R,4S)-3-fluoro-1-(methylsulfonyl)piperidin-4-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)-7-(methylamino)-6,7,8,8a-tetrahydro-4H-thieno[2,3-a]pyrrolizin-4-one;
8a-Ethyl-2-(2-((1-((1-methyl-1H-pyrazol-4-yl)sulfonyl)piperidin-4-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)-7-(methylamino)-6,7,8,8a-tetrahydro-4H-thieno[2,3-a]pyrrolizin-4-one;
7-(Dimethylamino)-8a-ethyl-2-(2-((1-((1-methyl-1H-pyrazol-4-yl)sulfonyl)piperidin-4-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)-6,7,8,8a-tetrahydro-4H-thieno[2,3-a]pyrrolizin-4-one;
or a pharmaceutically acceptable salt thereof.