Patent ID: 11898055
Assignee: UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
Field: Medical technology (Instruments)
Classification: CPC C  A  B | IPC A  B  C

Claim 9:
10. A coated medical implant device, comprising:
a substrate selected from the group comprising magnesium metal, magnesium alloy, iron metal, iron alloy, ferrous metal and ferrous alloy;
a pretreatment agent selected from the group consisting of alkali metal hydroxide, hydrogen fluoride, alkali metal carbonates, and mixtures thereof, applied to a surface of the substrate to form a charged substrate having a positive charge or a negative charge;
a polyelectrolyte multilayer coating deposited on the charged substrate, comprising:
a plurality of interfacing, individual polymer layers, comprising:
one or more polymer layers having a positive charge; and
one or more polymer layers having a negative charge,

wherein an initial layer of the plurality of interfacing, individual polymer layers is deposited on the charged substrate and has a charge opposite the charged substrate, and
wherein the plurality of interfacing, individual polymer layers has alternating layers of the one or more polymer layers having a positive charge and the one or more polymer layers having a negative charge;
a chemical cross-linking agent deposited on an outer polymer layer forming a modified outer surface;
fibronectin immobilized on the modified outer surface; and
an active substance, in addition to the fibronectin, deposited on the modified outer surface.