Patent ID: 11945817
Assignee: KIND PHARMACEUTICAL
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 10:
11. A compound of Formula I, or an isotopically labeled compound thereof, or an optical isomer thereof, a geometric isomer thereof, a tautomer thereof or a mixture of various isomers, or a pharmaceutically acceptable salt thereof, or a prodrug thereof, wherein the compound is selected from the group consisting of:
(3′-cyclobutyl-6′-hydroxy-8′-oxo-8′H-spiro[cyclopentane-1,5′-indolizine]-7′-carbonyl) glycine;
(3′-cyclopropyl-6′-hydroxy-8′-oxo-8′H-spiro[cyclopentane-1,5′-indolizine]-7′-carbonyl) glycine;
(6′-hydroxy-3′-methyl-8′-oxo-8′H-spiro[cyclopentane-1,5′-indolizine]-7′-carbonyl)glycine;
(3′-(tert-butyl)-6′-hydroxy-8′-oxo-8′H-spiro[cyclopentane-1,5′-indolizine]-7′-carbonyl) glycine;
(3′-cyclopentyl-6′-hydroxy-8′-oxo-8′H-spiro[cyclopentane-1,5′-indolizine]-7′-carbonyl) glycine;
(3′-cyclohexyl-6′-hydroxy-8′-oxo-8′H-spiro[cyclopentane-1,5′-indolizine]-7′-carbonyl) glycine;
(6′-hydroxy-8′-oxo-3′-(pyridin-3-yl)-8′H-spiro[cyclopentane-1,5′-indolizine]-7′-carbonyl) glycine;
(6′-hydroxy-8′-oxo-3′-phenyl-8′H-spiro[cyclopentane-1,5′-indolizine]-7′-carbonyl)glycine;
(3′-(4-fluorophenyl)-6′-hydroxy-8′-oxo-8′H-spiro[cyclopentane-1,5′-indolizine]-7′-carbonyl) glycine;
(3′-(4-chlorophenyl)-6′-hydroxy-8′-oxo-8′H-spiro[cyclopentane-1,5′-indolizine]-7′-carbonyl) glycine;
(3′-(4-chlorophenyl)-6′-hydroxy-8′-oxo-8′H-spiro[cyclopentane-1,5′-indolizine]-7′-carbonyl)-L-alanine;
(6′-hydroxy-3′-(4-methoxyphenyI)-8′-oxo-8′H-spiro[cyclopentane-1,5′-indolizine]-7′-carbonyl glycine;
(6′-hydroxy-8′-oxo-3′-(4-methylphenyI)-8′H-spiro[cyclopentane-1,5′-indolizine]-7′-carbonyl) glycine;
(3′-cyclopropyl-6′-hydroxy-8′-oxo-8′H-spiro[cyclohexane-1,5′-indolizine]-7′-carbonyl)glycine;
(3′-tert-butyl-6′-hydroxy-8′-oxo-8′H-spiro[cyclohexane-1,5′-indolizine]-7′-carbonyl)glycine;
(6′-hydroxy-3′-methyl-8′-oxo-8′H-spiro[cyclohexane-1,5′-indolizine]-7′-carbonyl)glycine;
(3′-(4-chlorophenyl)-6′-hydroxy-8′-oxo-8′H-spiro[cyclopentane-1,5′-indolizine]-7′-carbonyl)-D-alanine;
(3′-cyclobutyl-6′-hydroxy-8′-oxo-8′H-spiro[cyclohexane-1,5′-indolizine]-7′-carbonyl) glycine;
(6′-hydroxy-8′-oxo-3′-phenyl-8′H-spiro[cyclohexane-1,5′-indolizine]-7′-carbonyl)glycine;
(3′-(4-chlorophenyl)-6′-hydroxy-8′-oxo-8′H-spiro[cyclohexane-1,5′-indolizine]-7′-carbonyl) glycine;
(3′-(4-fluorophenyl)-6′-hydroxy-8′-oxo-8′H-spiro[cyclohexane-1,5′-indolizine]-7′-carbonyl) glycine;
(6′-hydroxy-3′-(4-methoxyphenyI)-8′-oxo-8′H-spiro[cyclohexane-1,5′-indolizine]-7′-carbonyl glycine;
(6′-hydroxy-8′-oxo-3′-phenyl-8′H-spiro[cyclobutane-1,5′-indolizine]-7′-carbonyl)glycine;
(6′-hydroxy-8′-oxo-3′-phenyl-8′H-spiro[cyclopropane-1,5′-indolizine]-7′-carbonyl)glycine;
(6-hydroxy-5,5-dimethyl-8-oxo-3-phenyl-5,8-dihydroindolizin-7-carbonyl)glycine;
(6′-hydroxy-8′-oxo-3′-phenyl-8′H-spiro[cyclopentane-1,5′-indolizine]-7′-carbonyl)-L-alanine;
(6-hydroxy-8-oxo-3-phenyl-2′,3′,5′,6′-tetrahydro-8H-spiro[indolizin-5,4′-pyran]-7-carbonyl)glycine;
(6′-hydroxy-8′-oxo-3′-phenyl-8′H-spiro[cyclopentane-1,5′-indolizine]-7′-carbonyl)-D-alanine;
(3′-(4-fluorophenyl)-6′-hydroxy-8′-oxo-8′H-spiro[cyclopentane-1,5′-previous]-7′-carbonyl) glycine ethyl ester;
(6′-hydroxy-8′-oxo-3′-phenyl-8′H-spiro[cyclohexane-1,5′-indolizine]-7′-carbonyl)glycine-2,2-dideuterium;
(6′-Hydroxy-8′-oxo-3′-(phenyl-4-hydra)-8′H-spiro[cyclohexane-1,5′-indolizine]-7′-carbonyl) glycine;
(3′-(4-ChlorophenyI)-6′-hydroxy-8′-oxo-8′H-spiro[cyclopentane-1,5′-indolizine]-7′-carbonyl) glycine methyl ester;
(3′-(4-fluorophenyl)-6′-hydroxy-8′-oxo-8′H-spiro[cyclopentane-1,5′-indolizine]-7′-carbonyl) glycine methyl ester;
(6′-hydroxy-8′-oxo-T-phenyl-8′H-spiro[cyclopentane-1,5′-indolizine]-7′-carbonyhglycine-2,2-dideuterium;
(6′-hydroxy-3′-(4-hydroxyphenyl)-8′-oxo-8′H-spiro[cyclopentane-1,5′-indolizine]-7′-carbonyl)glycine;
(6′-hydroxy-3′-(2-methoxyphenyl)-8′-oxo-8′H-spiro[cyclopentane-1,5′-indolizine]-7′-carbonyl glycine; and
(6′-hydroxy-3′-(3-methoxyphenyl)-8′-oxo-8′H-spiro[cyclopentane-1,5′-indolizine]-7′-carbonyl glycine.