Patent ID: 11866426
Assignee: INCYTE CORPORATION
Field: Organic fine chemistry (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 33:
34. The method of claim 1, wherein:
A is N;
CyB is selected from C6-10 aryl optionally substituted with 1, 2, 3 or 4 substituents independently selected from R7;
R1 is selected from Cy1 and NRc1Rd1;
R2 is C1-6 alkyl optionally substituted with 1, 2, 3, or 4 substituents independently selected from R13;
R3 and R4 are each independently selected from H, D, C1-6 alkyl, C1-6 haloalkyl, halo, and CN; wherein said C1-6 alkyl is optionally substituted with 1, 2, 3, 4 substituents independently selected from Rg;
R5 is selected from H, D, C1-6 alkyl, C1-6 haloalkyl, halo, and CN;
R6 is selected from H, D, C1-6 alkyl, C1-6 haloalkyl, and CN;
each R7 is independently selected from C1-6 alkyl, C1-6 haloalkyl, 5-10 membered heteroaryl, halo, D, CN, ORa7, SRa7, C(O)NRc7Rd7, NRc7Rd7, and NRc7C(O)Rb7; wherein said C1-6 alkyl and 5-10 membered heteroaryl are each optionally substituted with 1, 2, 3, or 4 substituents independently selected from R8;
each R8 is independently selected from C1-6 alkyl, C1-6 haloalkyl, halo, D, CN, ORa8, and NRc8Rd8;
Cy1 is selected from 4-12 membered heterocycloalkyl, and 5-10 membered heteroaryl; wherein the 4-12 membered heterocycloalkyl and 5-10 membered heteroaryl each has at least one ring-forming carbon atom and 1, 2, 3, or 4 ring-forming heteroatoms independently selected from N, O, and S; wherein the N and S are optionally oxidized; wherein a ring-forming carbon atom of 5-10 membered heteroaryl and 4-12 membered heterocycloalkyl is optionally substituted by oxo to form a carbonyl group; and wherein the 4-12 membered heterocycloalkyl, and 5-10 membered heteroaryl are each optionally substituted with 1, 2, 3, or 4 substituents independently selected from R10;
each R10 is independently selected from C1-6 alkyl, C1-6 haloalkyl, C3-10 cycloalkyl, 4-10 membered heterocycloalkyl, C6-10 aryl, 5-10 membered heteroaryl, halo, D, CN, ORa10, SRa10, C(O)NRc10Rd10 NRc10Rd10, NRc10C(O)Rb10, and NRc10S(O)2Rb10; wherein said C1-6 alkyl, C3-10 cycloalkyl, 4-10 membered heterocycloalkyl, and C6-10 aryl, 5-10 membered heteroaryl are each optionally substituted with 1, 2, 3, or 4 substituents independently selected from R11;
each R11 is independently selected from C1-6 alkyl, C1-6 haloalkyl, halo, D, CN, ORa11 and NRc11Rd11;
each R13 is independently selected from halo, D, CN, ORa13, and NRc13Rd13;
each Rc1 and Rd1 is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C3-10 cycloalkyl and 4-10 membered heterocycloalkyl; wherein said C1-6 alkyl, C3-10 cycloalkyl and 4-10 membered heterocycloalkyl, are each optionally substituted with 1, 2, 3, or 4 substituents independently selected from R10;
or any Rc1 and Rd1 attached to the same N atom, together with the N atom to which they are attached, form a 4-10 membered heterocycloalkyl group optionally substituted with 1, 2, 3 or 4 substituents independently selected from R10;
each Ra7, Rc7 and Rd7 is independently selected from H and C1-6 alkyl; wherein said C1-6 alkyl, is optionally substituted with 1, 2, 3, or 4 substituents independently selected from R8;
each Ra8, Rc8 and Rd8 is independently selected from H and C1-6 alkyl;
each Ra10, Rc10, and Rd10 is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C3-10 cycloalkyl, 4-10 membered heterocycloalkyl; wherein said C1-6 alkyl, C3-10 cycloalkyl, and 4-10 membered heterocycloalkyl, are each optionally substituted with 1, 2, 3, or 4 substituents independently selected from R11;
or any Rc10 and Rd10 attached to the same N atom, together with the N atom to which they are attached, form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from R11;
each Rb10 is independently selected from C1-6 alkyl;
each Ra11, Rc11, and Rd11 is independently selected from H and C1-6 alkyl;
each Ra13, Rc13, and Rd13 is independently selected from H and C1-6 alkyl; and
each Rg is independently selected from OH, CN, halo, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, amino, C1-6 alkylamino, and di(C1-6 alkyl)amino.