Patent ID: 11896639
Assignee: YALE UNIVERSITY
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 0:
1. A method of treating a subject with cancer, the method comprising evaluating the quality and potential in vivo efficacy of a test batch of an herbal composition by subjecting the test batch of the herbal composition to one or more biological analysis methods selected from:
(a) a signaling transduction activity response assay; and
(b) a gene expression assay;
comparing the results of the biological analysis method(s) with results derived from a known batch of the herbal composition which has a known level of in vivo activity;
wherein if the test batch results have a correlation coefficient of between 0.90 and 1.0 with the known batch results, then the test batch is determined to have sufficiently similar quality as the known batch and potential in vivo activity,
wherein if the test batch of the herbal composition is determined to have sufficiently similar quality as the known batch, administering a therapeutically effective amount of the test batch of the herbal composition to the subject; and
wherein the herbal composition comprises one or more compositions selected from the group consisting of herbal extracts of Scutellaria baicalensis (S), Glycyrrhiza uralensis (G), Paeonia lactiflora (P), and Ziziphus jujuba (Z), and any fractions thereof.