Patent ID: 11872225
Assignee: AGIOS PHARMACEUTICALS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 6:
7. The method of claim 1, wherein Q is of one of the following formulae:, , wherein each instance of Rn is independently selected from hydrogen, halogen, —CN, —NO2, —N3, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted heterocyclyl, optionally substituted heteroaryl, —ORo4, —SRs1, —N(Rn2)2, —C(═O)N(Rn2)2, —N(Rn2)C(═O)Rc3, —C(═O)Rc3, —C(═O)ORo4, —OC(═O)Rc3, —S(═O)Rs1, —S(═O)2Rs1, —S(═O)ORo4, —OS(═O)Rc3, —S(═O)2ORo4, —OS(═O)2Rc3, —S(═O)N(Rn2)2, —S(═O)2N(Rn2)2, —N(Rn2)S(═O)Rs1, —N(Rn2)S(═O)2Rs1, —N(Rn2)C(═O)ORo4, —OC(═O)N(Rn2)2, —N(Rn2)C(═O)N(Rn2)2, —N(Rn2)S(═O)N(Rn2)2, —N(Rn2)S(═O)2N(Rn2)2, —N(Rn2)S(═O)ORo4, —N(Rn2)S(═O)2ORo4, —OS(═O)N(Rn2)2, —OS(═O)2N(Rn2)2, or two instances of Rn attached to the same or adjacent carbon atoms, taken together with the atoms to which they are attached form an optionally substituted cycloalkyl or a heterocycloalkyl;
each instance of Rna and Rnb is independently hydrogen, optionally substituted —C1-C6alkyl, or a nitrogen protecting group;
each instance of Rn2 is independently hydrogen, optionally substituted —C1-C6 alkyl, or a nitrogen protecting group;
each instance of Ro4 is independently hydrogen, optionally substituted —C1-C6 alkyl, or an oxygen protecting group;
each instance of Rc3 is independently optionally substituted —C1-C6 alkyl;
each instance of Rs1 is independently optionally substituted —C1-C6 alkyl, or a sulfur protecting group; and
n is 0, 1, 2, or 3, as valency permits.