Patent ID: 11872225
Assignee: AGIOS PHARMACEUTICALS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 8:
9. The method according to claim 1, wherein R2 is of one of the following formulae:, wherein each instance of Rp is independently selected from hydrogen, halogen, —CN, —NO2, —N3, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted heterocyclyl, optionally substituted heteroaryl, —ORo6, —SRs2, —N(Rn3)2, —C(═O)N(Rn3)2, —N(Rn3)C(═O)Rc4, —C(═O)Rc4, —C(═O)ORo6, —OC(═O)Rc4, —S(═O)Rs2, —S(═O)2Rs2, —S(═O)ORo6, —OS(═O)Rc4, —S(═O)2ORo6, —OS(═O)2Rc4, —S(═O)N(Rn3)2, —S(═O)2N(Rn3)2, —N(Rn3)S(═O)Rs2, —N(Rn3)S(═O)2Rs2, —N(Rn3)C(═O)ORo6, —OC(═O)N(Rn3)2, —N(Rn3)C(═O)N(Rn3)2, —N(Rn3)S(═O)N(Rn3)2, —N(Rn3)S(═O)2N(Rn3)2, —N(Rn3)S(═O)ORo6, —N(Rn3)S(═O)2ORo6, —OS(═O)N(Rn3)2, —OS(═O)2N(Rn3)2, or two instances of RP attached to the same or adjacent carbon atoms, taken together with the atoms to which they are attached form an optionally substituted cycloalkyl or a heterocycloalkyl;
each instance of Rn3, Rnc, and Rnd is independently hydrogen, optionally substituted —C1-C6 alkyl, or a nitrogen protecting group;
each instance of Ro6 is independently hydrogen, optionally substituted —C1-C6 alkyl, or an oxygen protecting group;
each instance of Rc4 is independently optionally substituted —C1-C6 alkyl;
each instance of Rs2 is independently optionally substituted —C1-C6 alkyl, or a sulfur protecting group; and
p is 0, 1, 2, or 3, as valency permits.