Patent ID: 11959924
Assignee: ADURO BIOTECH HOLDINGS, EUROPE B.V.
Field: Measurement (Instruments)
Classification: CPC G  C | IPC C  G

Claim 0:
1. A method for performing an ex vivo diagnostic test for the presence of A Proliferation-Inducing Ligand (APRIL) in a sample, comprising:
a) contacting the sample with an APRIL-binding antibody comprising:
i) a VH domain comprising an amino acid sequence having complementarity determining region (CDR) sequences set forth in SEQ ID NOs: 25-27, and a VL domain comprising an amino acid sequence comprising CDR sequences set forth in SEQ ID NOs: 28-30,
ii) a VH domain comprising an amino acid sequence having complementarity determining region (CDR) sequences set forth in SEQ ID NOs: 5-7 and a VL domain comprising an amino acid sequence comprising CDR sequences set forth in SEQ ID NOs: 8-10,
iii) a VH domain comprising an amino acid sequence having complementarity determining region (CDR) sequences set forth in SEQ ID NOs: 15-17 and a VL domain comprising an amino acid sequence comprising CDR sequences set forth in SEQ ID NOs: 18-20,
iv) a VH domain comprising an amino acid sequence having complementarity determining region (CDR) sequences set forth in SEQ ID NOs: 35-37 and a VL domain comprising an amino acid sequence comprising CDR sequences set forth in SEQ ID NOs: 38-40, or
v) a VH domain comprising an amino acid sequence having complementarity determining region (CDR) sequences set forth in SEQ ID NOs: 45-47 and a VL domain comprising an amino acid sequence comprising CDR sequences set forth in SEQ ID NOs: 48-50; and

b) detecting binding between APRIL in the human sample and the APRIL-binding antibody.