Patent ID: 11958896
Assignee: PROTHENA BIOSCIENCES LIMITED
Field: Biotechnology (Chemistry)
Classification: CPC C | IPC C

Claim 17:
18. A method of humanizing a mouse antibody, the method comprising:
(a) selecting one or more acceptor antibody sequences;
(b) identifying amino acid residues of the mouse antibody to be retained;
(c) synthesizing a nucleic acid encoding a humanized heavy chain comprising CDRs of the mouse antibody heavy chain and a nucleic acid encoding a humanized light chain comprising CDRs of the mouse antibody light chain; and
(d) expressing the nucleic acids in a host cell to produce a humanized antibody;
wherein the mouse antibody is characterized by a mature heavy chain variable region of SEQ ID NO: 7 and a mature light chain variable region of SEQ ID NO:8.