Patent ID: 11959842
Assignee: WATERS TECHNOLOGIES CORPORATION
Field: Measurement (Instruments)
Classification: CPC G | IPC G

Claim 0:
1. A method of separating a sample comprising:
providing a chromatographic system having a metallic flow path with an alkylsilyl coating on fluid exposed surfaces, the metallic flow path with the alkylsilyl coating preventing the sample from binding to underlying metal surfaces;
injecting the sample into the chromatographic system, wherein the sample comprises gentisic acid and/or 4-hydroxybenzoic acid;
flowing the sample through the chromatographic system; and
separating the sample, wherein coating the metallic flow path of the chromatographic system increases a chromatographic peak area of the gentisic acid and/or 4-hydroxybenzoic acid in the sample in comparison to an uncoated chromatographic system having metallic surfaces exposed to fluid by 1.3 × or greater.