Patent ID: 11957825
Assignee: IMMUNICOM INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  B  C  G | IPC A  B  C  G

Claim 0:
1. A column for removal of a soluble tumor necrosis factor receptor 2 (sTNF-R2) from a body fluid, the column comprising:
a compartment;
an inlet coupled to the compartment and configured to receive the body fluid;
a substrate disposed within the compartment; and
a capture ligand coupled to the substrate and comprising a modified sequence comprising an amino acid substitution in a reference sequence that comprises a portion of a natural tumor necrosis factor (TNF) sequence;
wherein the reference sequence is SEQ1 (SEQ ID NO: 1), and the modified sequence comprises an amino acid substituted at a site selected from a group consisting of sites 105, 221, 222, and 223 of SEQ1 (SEQ ID NO:1) and has an affinity for the sTNF-R2 that is greater than an affinity of the reference sequence for the sTNF-R2.