Patent ID: 11879126
Assignee: NUTCRACKER THERAPEUTICS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC B  C  A  Y | IPC A  C

Claim 0:
1. A therapeutic mRNA composition comprising:
a first mRNA scaffold comprising a first mRNA coding region encoding HPV16 E6 E7;
a second mRNA scaffold comprising a second mRNA coding region encoding interleukin-12, wherein the second mRNA coding region has at least about 80% nucleic acid sequence identity to SEQ ID NO:5; and
a third mRNA scaffold comprising a third mRNA coding region encoding tumor necrosis factor superfamily member 14 (TNFSF14) wherein the third mRNA coding region has at least about 80% nucleic acid sequence identity to SEQ ID NO:11, and
wherein the first mRNA scaffold, the second mRNA scaffold and, the third mRNA scaffold are encapsulated in a delivery vehicle, wherein the delivery vehicle is selected from the group consisting of lipid nanoparticles, polymer-based nanoparticles, cationic lipids, ionizable lipids, amino-lipidated peptoids, amphipathic molecules/nanoparticles, and tertiary amino lipidated cationic peptoids.