Patent ID: 11865158
Assignee: PURDUE RESEARCH FOUNDATION
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 0:
1. A process for preparing a pharmaceutical composition of zwitterionic chitosan (ZWC) coated-tannic acid-Fe (TZ) nanoparticles (NPs) comprising the step of:
a. adding an ethanol solution of tannic acid to an aqueous solution of FeCl3 to afford tannic acid-Fe (T) nanoparticles (NPs);
b. preparing succinylated chitosan to afford zwitterionic chitosan (ZWC);
c. adding ZWC to said T NPs to afford ZWC-coated tannic acid-Fe NPs (ZWC-T NPs, or TZ); and
d. adding one or more active pharmaceutical ingredients at an elevated pH to above prepared TZ to afford a stable form of zwitterionic chitosan-coated tannic acid-Fe nanoparticles (TZ).