Patent ID: 11896676
Assignee: CASE WESTERN RESERVE UNIVERSITY
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 0:
1. A method of targeting cancer tissue in a subject, comprising administering to the subject a pepino mosaic virus (PepMV) carrier comprising a PepMV particle modified to carry an imaging agent or a cytotoxic compound,
wherein the PepMV carrier targets cancer tissue selected from the group consisting of triple negative breast cancer (TNBC) tissue or ovarian cancer tissue and has increased tumor homing to triple negative breast cancer (TNBC) tissue and to ovarian cancer tissue compared to a potato virus X (PVX) carrier,
wherein the PepMV carrier is administered via systemic or intraperitoneal (i.p.) administration, and
wherein the PepMV carrier has 1.5-fold increase in tumor homing in triple negative breast cancer (TNBC) tumors and 2-fold increase in tumor homing in ovarian cancer tumors compared to a potato virus X (PVX) carrier.