Patent ID: 11958861
Assignee: INCYTE CORPORATION
Field: Organic fine chemistry (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 41:
42. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein:
W is CH2;
Y is CH2;
Ring A is selected from C3-7 cycloalkyl, monocyclic 4-6 membered heterocycloalkyl, and bicyclic 8-10 membered heterocycloalkyl, wherein the C3-7 cycloalkyl, monocyclic 4-6 membered heterocycloalkyl, and bicyclic 8-10 membered heterocycloalkyl of Ring A are each optionally substituted by 1, 2, 3, or 4 independently selected R6 substituents;
R2 is selected from phenyl and indazolyl, wherein the phenyl and indazolyl of R2 are each optionally substituted with 1, 2, 3, or 4 independently selected R2A substituents;
each R2A is independently selected from C1-6 alkyl, and 5-10 membered heteroaryl, wherein the C1-6 alkyl and 5-10 membered heteroaryl of R2A are each optionally substituted with 1 or 2 independently selected R2B substituents;
each R2B is independently selected from H and C1-6 alkyl, wherein the C1-6 alkyl of R2B is optionally substituted by CN;
R3 is selected from phenyl, cyclopropyl, and pyrazolyl, wherein the phenyl, cyclopropyl, and pyrazolyl of R3 are each optionally substituted with 1, 2, 3, or 4 independently selected R3A substituents;
each R3A is independently selected from C1-6 alkyl, (5-10 membered heteroaryl)-C1-6 alkyl-, and (4-10 membered heterocycloalkyl)-C1-6 alkyl-, wherein the C1-6 alkyl, (5-10 membered heteroaryl)-C1-6 alkyl-, and (4-10 membered heterocycloalkyl)-C1-6 alkyl- of R3A are each optionally substituted with 1, 2, 3, or 4 independently selected R3B substituents;
each R3B is independently selected from S(O)2Rb32;
each Rb32 is independently selected from H and C1-6 alkyl;
R4 is selected from H and C1-3 alkyl;
R5 is H;
each R6 is independently selected from C1-6 alkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, and C(O)Rb6, wherein the C1-6 alkyl, 5-10 membered heteroaryl, and 4-10 membered heterocycloalkyl of R6 are each optionally substituted with 1, 2, 3, or 4 independently selected R6A substituents;
each Rb6 is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, wherein the C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl of Rb6 are each optionally substituted by 1, 2, 3, or 4 independently selected R6A substituents;
each R6A is independently selected from 4-10 membered heterocycloalkyl, CN, and C(O)Rb61, wherein the 4-10 membered heterocycloalkyl of R6A are each optionally substituted with 1, 2, 3, or 4 independently selected R6B substituents;
each Rb61 is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, wherein the C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl of Rb61 are each optionally substituted by 1 or 2 independently selected R6B substituents;
each R6B is independently selected from C1-6 alkyl, wherein the C1-6 alkyl of R6B is optionally substituted by CN.