Patent ID: 11884024
Assignee: ROCHE SEQUENCING SOLUTIONS, INC.
Field: Measurement (Instruments)
Classification: CPC B  C  G  Y | IPC B  C  G

Claim 0:
1. A system for identifying a base of a nucleic acid molecule, comprising:
a sensing circuit configured to be coupled to a nanopore;
an electrical circuit configured to apply an electrical stimulus across the nanopore; and
a processor coupled to the sensing circuit, wherein the processor is programmed to:
control the sensing circuit to record a first electrical measurement indicative of a plurality of bases of the nucleic acid molecule as a strand of the nucleic acid molecule moves through the nanopore as a result of a first applied electrical stimulus;
control the electrical circuit to apply a second electrical stimulus across the nanopore that is configured to translocate the nucleic acid molecule through the nanopore;
control the sensing circuit to record a second electrical measurement indicative of the plurality of bases of the nucleic acid molecule as the strand of the nucleic acid molecule moves through the nanopore as a result of the second applied electrical stimulus, wherein the second electrical measurement is a repeat electrical measurement; and
identify the plurality of bases based on the first electrical measurement wherein the repeat measurement is used to increase confidence in the identification.