Patent ID: 11931399
Assignee: TAKEDA VACCINES, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C  Y | IPC A  C

Claim 1:
2. The modified live, attenuated dengue-2 virus strain PDK-53 according to claim 1, wherein the polynucleotide molecule encoding the modified live, attenuated dengue-2 virus strain PDK-53 polypeptide molecule further comprises at least one additional mutation of:
a guanine to cytosine mutation at nucleic acid position 6481 in the numbering of SEQ ID NO: 14 encoding a proline instead of an alanine in the polypeptide molecule at amino acid position 2129 in the numbering of SEQ ID NO: 6 corresponding to NS4A-36, and
a cytosine to thymine mutation at position 7156 in the numbering of SEQ ID NO: 14 encoding a phenylalanine instead of a leucine in the polypeptide molecule at amino acid position 2354 in the numbering of SEQ ID NO: 6 corresponding to NS4B-111.