Patent ID: 11891435
Assignee: AMGEN INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A  G  Y | IPC A  C  G

Claim 0:
1. An isolated polynucleotide that encodes a heavy chain polypeptide and a light chain polypeptide of a monoclonal antibody that specifically binds to human pituitary adenylate cyclase-activating polypeptide type I receptor (PAC1), wherein:
(i) the heavy chain polypeptide comprises a heavy chain variable region comprising complementarity determining regions CDRH1, CDRH2, and CDRH3, wherein CDRH1 comprises the sequence of SEQ ID NO: 88, CDRH2 comprises the sequence of SEQ ID NO: 108, and CDRH3 comprises the sequence of SEQ ID NO: 171; and
(ii) the light chain polypeptide comprises a light chain variable region comprising complementarity determining regions CDRL1, CDRL2, and CDRL3, wherein CDRL1 comprises the sequence of SEQ ID NO: 7, CDRL2 comprises the sequence of SEQ ID NO: 26, and CDRL3 comprises the sequence of SEQ ID NO: 36.