Patent ID: 11879016
Assignee: AUTOLUS LIMITED
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A method for treating cancer which comprises the step of administering a T cell to a subject,
wherein the T cell expresses a chimeric antigen receptor (CAR) comprising
a) a disialoganglioside (GD2)-binding domain and spacer, shown as amino acids 21 to 311 of SEQ ID NO: 29,
b) a hydrophobic alpha helical transmembrane domain, and
c) a CD28-CD3Zeta endodomain shown as SEQ ID NO: 17; and

wherein the cancer is a melanoma, medulloblastoma, soft-tissue sarcoma, osteosarcoma or small-cell lung cancer.