Patent ID: 11883485
Assignee: FRED HUTCHINSON CANCER CENTER
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A

Claim 0:
1. A method of eliciting antibodies that bind full length glycosylated human immunodeficiency virus (HIV)-1 envelope protein (Env) comprising administering to a subject:
(i) a prime immunization comprising a multimerized 426c core HIV-1 Env; and
(ii) a boost immunization comprising a multimerized HxB2 core HIV-1 Env with a glycosylated N276 wherein no Env are administered to the subject between the (i) prime immunization and (ii) boost immunization
thereby eliciting antibodies that bind full length glycosylated HIV-1 Env
wherein residue numbering is based on the prototypic HIV-1 isolate HxB2.