Patent ID: 11951272
Assignee: CITY UNIVERSITY OF HONG KONG
Field: Medical technology (Instruments)
Classification: CPC A  Y | IPC A

Claim 28:
29. A cryo formulation-based microneedle device for ocular delivery of bioactive therapeutic agents, comprising:
one or more microneedle patches each including an array of miniaturized needles, each miniaturized needle defining a base end and a tip; and
a substrate to which the base end of each miniaturized needle of the array of miniaturized needles is attached or integrated thereto;
wherein the one or more microneedle patches are in a cryo status;
wherein each of the one or more microneedle patches is adapted to be applied on a cornea of an eye, in which the miniaturized needles penetrate into the eye;
wherein each of the one or more microneedle patches comprises a matrix solution, wherein the matrix solution comprises glycerol, and wherein the amount of glycerol is from 1 to 5 wt. % of the matrix solution; and
wherein the miniaturized needles are further arranged to melt so as to release one or more bioactive therapeutic agents into the eye to achieve a targeted therapeutic effect; and
wherein the one or more bioactive therapeutic agents comprise predatory bacteria.