Patent ID: 11931373
Assignee: UNIVERSITY OF SOUTH FLORIDA
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 0:
1. A composition comprising an Aha1 inhibitor for treatment of a tauopathy in a subject in need thereof,
wherein the Aha1 inhibitor comprises at least one of 3-(3′,6-dimethoxy-[1,1′-biphenyl]-3-carboxamido)-8-methoxy-2-oxo-2H-chromen-7-yl acetate (KU-177), N-(7-(((2S,3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-8-methoxy-2-oxo-2H-chromen-3-yl)-3′,6 dimethoxy-[1,1′-biphenyl]-3-carboxamide (KU-174), N-(7-hydroxy-8-methoxy-2-oxo-2H-chromen-3-yl)-3′,6-dimethoxy-[1,1′-biphenyl]-3-carboxamide (KU-308), or any combination thereof; and
one or more pharmaceutically acceptable carriers;
wherein the Aha1 inhibitor is in a form suitable for systemic administration, parenteral administration, or oral administration;
wherein the Aha1 inhibitor that is in the form suitable for systemic administration comprises about 0.01% to about 50% of the Aha1 inhibitor and about 50% to about 99.99% of the one or more pharmaceutically acceptable carriers;
wherein the Aha1 inhibitor that is in the form suitable for parenteral administration comprises about 0.1% to 10% of the Aha1 inhibitor and about 90% to about 99.9% of the one or more pharmaceutically acceptable carriers; and
wherein the Aha1 inhibitor that is in the form suitable for oral administration comprises about 5% to about 50% of the Aha1 inhibitor and about 50% to about 95% of the one or more pharmaceutically acceptable carriers.