Patent ID: 11965206
Assignee: nan
Field: Medical technology (Instruments)
Classification: CPC C  G | IPC C  G

Claim 10:
11. A computer-based method of treating a patient with multiple drugs, wherein the multiple drugs are inducers and/or inhibitors of CYP450 enzymes and the patient has various disease states and is in need of treatment thereof with the multiple drugs, comprising:
1) obtaining, by one or more users, tissue or fluid from a patient, analyzing the tissue or fluid, and obtaining CYP450 enzyme genotypes of the patient;
2) entering, by one or more users through one or more users' computer systems into a computer system of a service provider over a network, names of the multiple drugs and the CYP450 enzyme genotypes of the patient, wherein a dose per drug label of each of the multiple drugs is known by the one or more users;
3) converting, by the computer system of a service provider, the CYP450 enzyme genotypes of the patient to standard baseline phenotypes using a table of standard baseline phenotypes provided in the computer system of the service provider;
4) providing, by the computer system of the service provider, a numerical score for each of the standard baseline phenotypes using a table of standard phenotype scores for baseline phenotypes programmed in one or more users' computer systems;
5) searching by the computer system of the service provider one or more drug databases and identifying by the computer system of the service provider each of said multiple drugs that is an inducer or inhibitor of each of the CYP450 enzymes;
6) for each of the multiple drugs that is an inducer, adjusting by the computer system of the service provider the standard baseline phenotype scores for the CYP450 enzymes which are induced using an inducer factor obtained from an inducer factor table programmed in the computer system of the service provider, and for each of the multiple drugs that is an inhibitor, adjusting, by the computer system of the service provider, the standard baseline phenotype scores for the CYP450 enzymes which are inhibited using an inhibitor factor obtained from an inhibitor factor table programmed in the computer system of the service provider, thereby obtaining an adjusted phenotype score for each of the CYP450 enzymes which are induced or inhibited;
7) converting, by the computer system of the service provider, the adjusted phenotype scores to adjusted phenotypes for each CYP450 enzyme which is induced or inhibited, using an adjusted phenotype look up table provided in the computer system of the service provider;
8 displaying to the one or more users, by the one or more users' computer systems, adjusted phenotypes for each CYP450 enzyme which is induced or inhibited;
9) determining by the one or more users the risk of occurrence of adverse events with the use of each of these multiple drugs based upon the displayed adjusted phenotype of each CYP450 enzyme for which each of the these multiple drugs is a substrate, adjusting, by the one or more users, the dose per drug label of each of the multiple drugs based upon the determination of risk of occurrence of adverse events with the use of each of the multiple drugs, and providing the adjusted dose of the dose per drug label of each of the multiple drugs; and
10) receiving by the patient for each of the multiple drugs the adjusted dose of the dose per drug label, thereby minimizing the side effects of the multiple drug dosing in the patient.