Patent ID: 11919893
Assignee: KING FAISAL UNIVERSITY
Field: Organic fine chemistry (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 3:
4. A method of making the 7-(4-((5-(2-bromobenzylideneamino)-2-thioxo-1,3,4-thiadiazol-3(2H)-yl)methyl)piperazin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid compound of claim 1, the method comprising:
adding a solution of 5-(2-bromobenzylideneamino)-1,3,4-thiadiazole-2(3H)-thione and formaldehyde to ethanol to obtain a first reaction mixture;
stirring the first reaction mixture;
adding ciprofloxacin HCl and triethylamine to the first reaction mixture to obtain a second reaction mixture;
stirring the second reaction mixture with reflux;
purifying the crude product by recrystallization using ethanol; and
obtaining the 7-(4-((5-(2-bromobenzylidene amino)-2-thioxo-1,3,4-thiadiazol-3(2H)-yl)methyl)piperazin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid.