Patent ID: 11951168
Assignee: PERSEUS PROTEOMICS INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 1:
2. A method of producing a radioactive metal-labeled chelated targeting agent, the method comprising:
adding a radioactive metal selected from the group consisting of 90Y, 153Sm, 165Dy, 165Er, 166Ho, and 177Lu to a mixture of a chelated targeting agent selected from the group consisting of a low-molecular-weight compound, a peptide, a protein, an antibody, an antibody fragment, and a nucleic acid chelated with at least one member selected from the group consisting of:, and at least one compound selected from the group consisting of benzoic acid, maleic acid, a conjugate base of benzoic acid, a conjugate base of maleic acid, a mixture of benzoic acid and a conjugate base of benzoic acid, and a mixture of maleic acid and a conjugate base of maleic acid, to form a complex between the radioactive metal and the chelated targeting agent,
wherein a pH of a reaction liquid at the time of labelling of the chelated targeting agent with the radioactive metal is adjusted to fall within a range of the pKa value of the compound plus or minus 1.5.