Patent ID: 11862337
Assignee: CAMBRIDGE COGNITION LIMITED
Field: Medical technology (Instruments)
Classification: CPC G  A | IPC A  G

Claim 0:
1. A method of treating an individual subjected to a non-invasive computational device-based test for latent inhibition assessment, comprising:
a. having the individual perform a latent inhibition assessment using the computational device and a graphical user interface coupled thereto, the latent inhibition assessment comprising a pre-exposure phase and a test phase,
i. wherein the pre-exposure phase comprises,
presenting the individual with a first set of directions for how to respond to each stimulus of a first group of stimuli, wherein the first set of directions include pre-exposure phase instructions which require the individual to respond to each stimulus of the first group of stimuli in a defined manner;
presenting the individual with a random order of the first group of stimuli, each stimulus being presented for a presentation time between 10 msec to 10,000 msec, wherein the first group of stimuli comprises a plurality of stimuli including at least one preexposed stimulus and one or more neutral stimuli, wherein the at least one preexposed stimulus is a pre-target stimulus;

ii. wherein the test phase comprises,
presenting the individual with a second set of directions for how to respond to each stimulus of a second group of stimuli, wherein the second set of directions include test phase instructions which require the individual to anticipate the occurrence of a target stimulus;
presenting the individual with the second group of stimuli, each stimulus being presented for the presentation time between 10 msec to 10,000 msec, wherein the second group of stimuli comprises a plurality of stimuli including the at least one preexposed stimuli, a non-preexposed stimulus, the target stimulus, and the one or more neutral stimuli, wherein the non-preexposed stimulus is a pre-target stimulus that was not shown during the pre-exposure phase;
recording and analyzing the individual's interaction with the graphical user interface following presentation of each stimulus from the second group of stimuli by measuring a response time associated with each stimulus from the plurality of stimuli to determine a target anticipated response, wherein an anticipatory response to the target stimulus of less than the sum of the presentation time and interval time according to the second set of directions is indicative that the individual anticipated the occurrence of the target stimulus, and wherein an anticipatory response to the target stimulus of equal to or more than the sum of the presentation time and interval time according to the second set of directions is indicative that the individual failed to anticipate the occurrence of the target stimulus;

b. measuring a latent inhibition response of the individual by calculating a latent inhibition score by modeling each target anticipated response in one or more statistical analyses within a computing environment in which a plurality of data processing components are executed in conjunction with at least one specifically configured processor, the one or more statistical analyses comprising
i. determining one or more reaction times associated with each target stimulus from the plurality of stimuli,
ii. determining a number of anticipatory responses indicative that the individual anticipated the occurrence of the target stimulus,
iii. determining a number of anticipatory responses indicative that the individual failed to anticipate the occurrence of the target stimulus,
iv. determining a percentage of anticipatory responses indicative that the individual anticipated the occurrence of the target stimulus,
v. determining a percentage of anticipatory responses indicative that the individual failed to anticipate the occurrence of the target stimulus, or
vi. determining an accuracy sensitivity d′,
wherein the calculated latent inhibition score is used to classify whether the individual exhibited an attenuated latent inhibition response, a normal latent inhibition response or an enhanced latent inhibition response from the latent inhibition score; and

c. treating the individual, wherein the treating comprises at least one of:
i. calculating the attenuated latent inhibition response in step (b) and wherein this is an initial assessment, the individual is not currently experiencing psychotic symptoms, the individual has no history of a psychotic disorder, and the individual has no history of resistance to anti-psychotic drug treatment, treating the individual with an anti-psychotic drug;
ii. calculating the enhanced latent inhibition response in step (b) and wherein this is an initial assessment, the individual is not currently experiencing psychotic symptoms, the individual has no history of a psychotic disorder, and the individual has no history of resistance to anti-psychotic drug treatment, treating the individual with a pro-cognitive drug;
iii. calculating the attenuated latent inhibition response in step (b) and wherein this is an initial assessment, the individual is currently experiencing psychotic symptoms, the individual has no history of psychotic disorder, and the individual has no history of resistance to anti-psychotic drug treatment, treating the individual with an anti-psychotic drug;
iv. calculating the enhanced latent inhibition response in step (b) and wherein this is an initial assessment, the individual is currently experiencing psychotic symptoms, the individual has no history of a psychotic disorder, and the individual has no history of resistance to anti-psychotic drug treatment, treating the individual with clozapine or an alternative drug for treatment-resistant psychotic symptoms and a pro-cognitive drug;
v. calculating the attenuated latent inhibition response in step (b) and wherein the individual has a history of a psychotic disorder, and the individual has no history of resistance to anti-psychotic drug treatment, treating the individual with an anti-psychotic drug and a pro-cognitive drug;
vi. calculating the enhanced latent inhibition response in step (b) and wherein the individual has a history of a psychotic disorder, and the individual has no history of resistance to anti-psychotic drug treatment, treating the individual with a pro-cognitive drug as an add on therapy;
vii. calculating the attenuated latent inhibition response in step (b) and wherein the individual is currently experiencing psychotic symptoms, the individual has a history of a psychotic disorder, and the individual has a history of resistance to an anti-psychotic drug treatment, treating the individual with an anti-psychotic drug and a pro-cognitive drug; or
viii. calculating the enhanced latent inhibition response in step (b) and wherein the individual is currently experiencing psychotic symptoms, the individual has a history of a psychotic disorder, and the individual has a history of resistant to an anti-psychotic drug treatment, treating the individual with clozapine or an alternative drug for treatment-resistant psychotic symptoms and a pro-cognitive drug.