Patent ID: 11884724
Assignee: MERCK PATENT GMBH
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 1:
2. The isolated anti-PD-L1 antibody or antigen binding fragment of claim 1, wherein the heavy chain variable region comprises HVR-H1, HVR-H2 and HVR-H3 sequences, wherein:
(a) the HVR-H1 sequence is X1YX2MX3 (SEQ ID NO:1);
(b) the HVR-H2 sequence is SIYPSGGX4TFYADX5VKG (SEQ ID NO:2); and
(c) the HVR-H3 sequence is IKLGTVTTVX6Y (SEQ ID NO:3); and, further wherein:
X1 is K, R, T, Q, G, A, W, M, I or S;
X2 is V, R, K, L, M or I;
X3 is H, T, N, Q, A, V, Y, W, F or M;
X4 is F or I;
X5 is S or T; and
X6 is E or D.