Patent ID: 11912999
Assignee: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. An aptamer-N-heterocyclic-carbene metal complex conjugate (aptamer-NHCM conjugate), comprising:
a N-heterocyclic-carbene metal complex (NHCM) comprising two or more N-heterocylic carbenes (mono-NHCs) or a bis-N-heterocyclic carbene (bis-NHC) complexed to a single metal, and at least two N-heterocyclic carbenes (as a combination of two different mono-NHCs, a single NHC of the bis-NHC and a mono-NHC, or each NHC of the bis-NHC) are modified carbenes,
wherein each modified carbene independently comprises the N-heterocyclic carbene bound via a coupling unit to an aptamer, and the coupling unit comprises a hydrolytically stable bond.