Patent ID: 11925547
Assignee: SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION
Field: Medical technology (Instruments)
Classification: CPC A  B  C | IPC A  B  C

Claim 0:
1. An in-vivo implantable prosthesis coated with a crosslinked polymeric surface by crosslinking a coating composition comprising a photoinitiator, a crosslinking agent, and a phosphorylcholine monomer having an acrylate group,
wherein the photoinitiator is selected from the group consisting of benzophenone, benzoyl peroxide, and 2,2-dimethoxy-2-phenylacetophenone;
wherein the coating composition comprises the photoinitiator in an amount ranging from 0.01 to 0.2 mol % and the crosslinking agent in an amount ranging from 0.01 to 2.0 mol %, with respect to the phosphorylcholine monomer;
wherein crosslinked polyphosphorylcholine formed by crosslinking the coating composition is covalently bonded with an external surface of the in-vivo implantable prosthesis; and
wherein the external surface material of the in-vivo implantable prosthesis comprises polydimethylsiloxane having functional groups which provide radicals that react with a terminal C═C bond of the acrylate group of phosphorylcholine via the photoinitiator to form covalent bonds.