Patent ID: 11939307
Assignee: INSTITUTE OF MEDICINAL BIOTECHNOLOGY, CHINESE ACADEMY OF MEDICAL SCIENCES
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC C

Claim 5:
6. The compound as claimed in claim 1 having the structure shown in the formula III or a pharmaceutically acceptable salt thereof:, 1Aryl is the same as or different from 2Aryl, 1Aryl and 2Aryl are each a benzene ring or aza aromatic ring, or a substituted benzene ring or aza aromatic ring, the aza aromatic ring is a heteroaromatic ring containing 1 to 2 nitrogen atoms, rings, the substitution is that 1 to 2 substituents are at any position on the ring, and the substituents are selected from the group consisting of hydrogen, alkyl, cycloalkyl, alkoxy, phenoxy or substituted phenoxy, alkylthio, phenylthio, phenylthio or substituted phenylthio, haloalkyl, cyano and halogen;
R1 is alkyl containing 1 to 4 carbons or H;
R3 is cyano or trifluoromethyl;
X is N or CH;
R4 is substituted alkyl or substituted heterocycloalkyl, and when R4 is substituted alkyl, the substituent is selected from the group consisting of alkylamino, dialkylamino, and saturated or unsaturated heterocyclyl containing one nitrogen or two nitrogens; when R4 is a substituted heterocycloalkyl, the heterocycloalkyl contains at least one nitrogen atom, and the substituent is selected from the group consisting of alkyl, alkylamino and dialkylamino;
R5 is hydrogen or an alkyl containing 1-4 carbons;
or, R5, R4 and the nitrogen atom to which they are bonded together form a saturated heterocycle or a saturated heterocycle substituted by a substituent, and the heterocycle is a five-, six- or seven-membered heterocycle containing one or two nitrogen atoms, the substituents are selected from the group consisting of alkyl containing 1 to 6 carbon atoms, alkylamino, di-C1-C4 alkylamino, cycloalkyl containing 3 to 5 carbon atoms or saturated heterocyclic groups containing one nitrogen.