Patent ID: 11873484
Assignee: MICROSOFT TECHNOLOGY LICENSING, LLC
Field: Biotechnology (Chemistry)
Classification: CPC C  B  G | IPC B  C  G

Claim 8:
9. A system for selectively assembling an oligonucleotide, the system comprising:
a microelectrode array coated with a plurality of anchor sequences;
a reaction chamber containing the microelectrode array;
means for introducing a first oligonucleotide complex encoding a first arbitrary value into the reaction chamber;
means for activating a first subset of electrodes in the microelectrode array to attract the first oligonucleotide complex to the first subset of electrodes having attached thereto a first subset of anchor sequences;
means for introducing a second oligonucleotide complex encoding a second arbitrary value into the reaction chamber;
means for activating a second subset of electrodes in the microelectrode array to attract the second oligonucleotide complex to the second subset of electrodes having attached thereto a second subset of anchor sequences; and
means for closing nicks in assembled double-stranded oligonucleotides attached to the microelectrode array, the assembled double-stranded oligonucleotides formed at least in part by hybridization of the first oligonucleotide complex to the first subset of anchor sequences or by hybridization of the second oligonucleotide complex to the second subset of anchor sequences.