Patent ID: 11970482
Assignee: LIGAND PHARMACEUTICALS INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 0:
1. A compound having the structure of Formula I:, or a pharmaceutically acceptable salt thereof, wherein:
R1 is selected from the group consisting of optionally substituted C1-8alkyl, —COOR5, optionally substituted C2-10alkoxyalkyl, and 3-12 membered heterocyclyl optionally substituted with one or more R15, or alternatively:
(i) R1 and R2 together with the atoms to which they are attached form an optionally substituted 4-10 membered heterocyclyl, or
(ii) R1 and R3 together, with the atoms to which they are attached form an optionally substituted 6-10 membered heterocyclyl;

R2 is selected from the group consisting of H, —C(O)R6, and optionally substituted C2-10alkoxyalkyl, or alternatively:
(i) R1 and R2 together with the atoms to which they are attached form an optionally substituted 4-10 membered heterocyclyl, or
(ii) R2 and R3 together with the atoms to which they are attached form a 6-10 membered heterocyclyl, optionally substituted with one or more R7;

R3 is selected from the group consisting of H, —C(O)R8, and optionally substituted C2-10alkoxyalkyl, or alternatively:
(i) R1 and R3 together with the atoms to which they are attached form an optionally substituted 6-10 membered heterocyclyl, or
(ii) R2 and R3 together with the atoms to which they are attached form a 6-10 membered heterocyclyl, optionally substituted with one or more R7;

R4 is, R5 is selected from the group consisting of halogen, optionally substituted C2-6alkynyl, optionally substituted C6-10aryl, and optionally substituted 5-10 membered heteroaryl;
R6 is selected from the group consisting of H, halogen, optionally substituted C2-6alkenyl, optionally substituted C2-6alkynyl, optionally substituted C3-7carbocyclyl, and optionally substituted 3-10 membered heterocyclyl;
R8 is selected from the group consisting of H, optionally substituted C1-6alkyl, halogen, optionally substituted C2-6alkenyl, optionally substituted C2-6alkynyl, optionally substituted C3-7carbocyclyl, optionally substituted C6-10aryl, optionally substituted 5-10 membered heteroaryl, and optionally substituted 3-10 membered heterocyclyl; and
each R7 is independently selected from the group consisting of optionally substituted C1-8alkyl, oxo, optionally substituted C6-18aryl, and optionally substituted 5-18 membered heteroaryl;
each R15 is selected from the group consisting of C1-6alkyl, C1-6alkenyl, C1-6alkynyl, C1-6heteroalkyl, C3-7carbocyclyl, 3-10 membered heterocyclyl, C6-18aryl, C6-18aryl C1-6alkoxy, 5-10 membered heteroaryl, 5-10 membered heteroaryl C1-6alkyl, halo, cyano, hydroxyl, C1-6alkoxy, C2-10alkoxyalkyl, aryloxy, sulfhydryl, haloC1-6alkyl, haloC1-6alkoxy, C1-6alkylthio, C6-18arylthio, and nitro;
wherein when an alkyl group is substituted, it is substituted with one or more substituents selected from the group consisting of: C1-C6alkyl; C1-C6alkenyl; C1-C6alkynyl; C1-C6heteroalkyl; C3-C7carbocyclyl optionally substituted with halo, C1-C6alkyl, C1-C6alkoxy, C1-C6haloalkyl, and C1-C6haloalkoxy; C3-C7carbocyclyl-C1-C6-alkyl optionally substituted with halo, C1-C6alkyl, C1-C6alkoxy, C1-C6haloalkyl, and C1-C6haloalkoxy; 3-10 membered heterocyclyl optionally substituted with halo, C1-C6alkyl, C1-C6alkoxy, C1-C6haloalkyl, and C1-C6haloalkoxy; 3-10 membered heterocyclyl-C1-C6-alkyl optionally substituted with halo, C1-C6alkyl, C1-C6alkoxy, C1-C6haloalkyl, and C1-C6haloalkoxy; aryl optionally substituted with halo, C1-C6alkyl, C1-C6alkoxy, C1-C6haloalkyl, and C1-C6haloalkoxy; aryl(C1-C6)alkyl optionally substituted with halo, C1-C6alkyl, C1-C6alkoxy, C1-C6haloalkyl, and C1-C6haloalkoxy; 5-10 membered heteroaryl optionally substituted with halo, C1-C6alkyl, C1-C6alkoxy, C1-C6haloalkyl, and C1-C6haloalkoxy; 5-10 membered heteroaryl(C1-C6)alkyl optionally substituted with halo, C1-C6alkyl, C1-C6alkoxy, C1-C6haloalkyl, and C1-C6haloalkoxy; halo; cyano; hydroxyl; C1-C6alkoxy; C1-C6alkoxy(C1-C6 )alkyl; aryloxy; sulfhydryl; halo(C1-C6)alkyl; halo(C1-C6)alkoxy; C1-C6alkylthio; arylthio; amino; amino(C1-C6)alkyl; nitro; O-carbamyl ; N-carbamyl; O-thiocarbamyl; N-thiocarbamyl; C-amido; N-amido; S-sulfonamido; N-sulfonamido; C-carboxy; O-carboxy; acyl; cyanate; isocyanato; thiocyanato; isothiocyanato; sulfinyl; and sulfonyl;
wherein at least one of R2 and R3 is not H; and
wherein if R1 and R3 together with the atoms to which they are attached form a 6 membered heterocyclyl, then R2 is not H.