Patent ID: 11869630
Assignee: CONGENICA LTD.
Field: Computer technology (Electrical engineering)
Classification: CPC G | IPC G

Claim 16:
17. A method of using a screening system that:
processes in operation a biological sample comprising one or more maternal blood samples from a pregnant mother in a wet-laboratory arrangement configured to determine a presence of cell-free DNA fragments therein by enriching cell free fetal DNA fragments present in cell-free DNA derived from plasma of the one or more maternal blood samples that start within a nucleosome and have a shorter nucleic acid base count than an average length nucleic acid base count of cell-free DNA in the one or more maternal blood samples to sequence the DNA fragments; and
uses in operation a data processing arrangement configured to compare information representative of the sequenced DNA fragments against information stored in a genomic database arrangement to provide an assessment score in respect of the biological sample,
wherein the method includes operating the screening system to apply a modification to one or more stochastic ratings associated with the information representative of the sequenced DNA fragments using secondary information provided to the screening system to reduce a stochastic and/or systemic uncertainty present in the assessment score.