Patent ID: 11931343
Assignee: ARCUS BIOSCIENCES, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 0:
1. A compound represented by formula (Ia) or (Ib):, or a pharmaceutically acceptable salt, hydrate, N-oxide, or solvate thereof, wherein,
each of A2 and A4 is independently selected from the group consisting of C, CH and N;
A3 is selected from the group consisting of C(O), CH and N;
each E1 and E2 is independently selected from the group consisting of N, C(O) and CR1;
E3 is selected from the group consisting of N, NR1 and CR1;
at least two of A2, A3, A4, E1, E2 and E3 are N or NR1;
each R1 is independently selected from the group consisting of hydrogen, halogen, CN, NH2, NH—C1-C6 alkyl, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, and C1-C6 haloalkoxy, wherein NH2, NH—C1-C6 alkyl, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, and C1-C6 haloalkoxy are each substituted with from 0 to 3 R;
Y is an optionally substituted 5-6 membered heteroaryl or an optionally substituted 4-7 membered heterocycle, wherein said 5-6 membered heteroaryl and 4-7 membered heterocycle have from 1 to 3 ring heteroatoms independently selected from N, O, S, SO, and SO2;
Q is selected from the group consisting of NH, CH2, and O;
each R is independently selected from the group consisting of H, halogen, CN, NH2, NHRa, NRaRb, Rc, OH, ORa, SRa, S(O)2Ra, —Xa—NH2, —Xa—NHRa, —Xa—NRaRb, —Xa—OH, —Xa—ORa, —Xa—Ra, —Xa—SRa, and —Xa—S(O)2Ra;
each Ra, Rb and Rc is independently selected from the group consisting of C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 hydroxyalkyl, C3-7 cycloalkyl, C2-C6 alkenyl, and C2-C6 alkynyl, or Ra and Rb attached to N form a 4- to 7-membered ring; and
each Xa is independently selected from the group consisting of C(O), C1-C4 alkylene, —O—C1-C4 alkylene, and C1-C4 alkylene-O—.