Patent ID: 11911373
Assignee: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 0:
1. A method comprising the steps of:
(i) diagnosing or selecting a subject in need of a stimulant attention deficit hyperactivity disorder (ADHD) drug;
(ii) conducting an auditory sustained attention (ASAT) analysis on said subject;
(iii) administering said stimulant ADHD drug to said subject having lower baseline ASAT performance compared to a control value,.
wherein conducting the ASAT analysis comprises:
providing an acoustic background noise;
providing a first acoustic startle stimulus at an intensity higher than the background noise;
providing second acoustic startle stimuli comprising a pre-plus acoustic stimulus and an acoustic startle stimulus; and
calculating a Pre-Plus Inhibition (PPI) as a percentage of response inhibition between the first acoustic startle stimulus and the second acoustic startle stimuli; and
determining ASAT performance based on the calculated PPI.