Patent ID: 11873304
Assignee: INCYTE CORPORATION
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 29:
30. The method of claim 2, wherein each R8A is independently selected from halo, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, phenyl, C3-7 cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C1-4 alkyl, C3-7 cycloalkyl-C1-4 alkyl, (5-6 membered heteroaryl)-C1-4 alkyl, (4-7 membered heterocycloalkyl)-C1-4 alkyl, CN, ORa81, SRa81, C(O)Rb81, C(O)NRc81Rd81, C(O)ORa81, OC(O)Rb81, OC(O)NRc81Rd81, NRc81Rd81, NRc81C(O)Rb81, NRc81C(O)ORa81, NRc81C(O)NRc81Rd81, NRc81S(O)NRc81Rd81, NRc81S(O)Rb81, and NRc81S(O)2Rb81, wherein the C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, phenyl, C3-7 cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C1-4 alkyl, C3-7 cycloalkyl-C1-4 alkyl, (5-6 membered heteroaryl)-C1-4 alkyl, and (4-7 membered heterocycloalkyl)-C1-4 alkyl of R8A are each optionally substituted with 1, 2, 3, or 4 independently selected R8B substituents; and
wherein each Ra81, Rb81, Rc81 and Rd81 is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, phenyl, C3-7 cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C1-4 alkyl, C3-7 cycloalkyl-C1-4 alkyl, (5-6 membered heteroaryl)-C1-4 alkyl, and (4-7 membered heterocycloalkyl)-C1-4 alkyl, wherein the C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, phenyl, C3-7 cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C1-4 alkyl, C3-7 cycloalkyl-C1-4 alkyl, (5-6 membered heteroaryl)-C1-4 alkyl, and (4-7 membered heterocycloalkyl)-C1-4 alkyl of Ra81, Rb81, Rc81, and Rd81 are each optionally substituted with 1, 2, 3, or 4 independently selected R8B substituents;
or, any Rc81 and Rd81, attached to the same N atom, together with the N atom to which they are attached, form a 4-10 membered heterocycloalkyl group, wherein the 4-10 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected R8B substituents.