Patent ID: 11964026
Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 16:
17. The particle of claim 1, wherein
the first lipid covalently bonded to the affinity ligand is 1,2-dioleoyl-sn-glycero-3-[(N-(5-amino-1-carboxypentyl)iminodiacetic acid)succinyl];
the particle further comprises a metal ion selected from the group consisting of Fe(III), Co(II), Ni(II), Cu(II), and Zn(II);
the metal ion is coordinated with the affinity ligand, thereby forming a metal-coordinated ligand;
the metal-coordinated ligand is non-covalently associated with the tag;
the tag is a peptide tag;
the peptide tag is at least two amino acid monomers in length;
the peptide tag comprises a histidine monomer;
the cytokine is a single-chain variant of IL-12; and
the polycation is selected from the group consisting of polyarginine and polylysine.