Patent ID: 11944424
Assignee: DUKE UNIVERSITY
Field: Measurement (Instruments)
Classification: CPC A  G | IPC A  G

Claim 27:
28. A method of generating spectroscopy parameters, comprising:
providing an inhalable hyperpolarized 129Xe gas to a subject;
obtaining, from a Magnetic Resonance Imaging (MRI) scanner, a series of 129Xe free induction decays (FIDs) of a gas exchange region of a lung or lungs of the subject during a breathing maneuver while the subject is held in a bore of a magnet of the MM scanner;
electronically fitting the FIDs with a curve fitting function modeled with one or more non-Lorentzian line shapes;
electronically generating a plurality of 129Xe spectral parameters based on the fitting, wherein the plurality of 129Xe spectral parameters include static and/or dynamic 129Xe spectral parameters using plots over time of:
(i) barrier amplitude, barrier chemical shift (ppm), and one or more barrier full width at half maximum (FWHM)(ppm) parameters; and
(ii) red blood cell (RBC) amplitude, RBC chemical shift (ppm), RBC FWHM (ppm), and RBC phase (degrees); and
electronically adjusting amplitude “ARBc” of the RBC amplitude plot by multiplying by:

(V_stroke_ref/V_stroke)*(PEV/PEV_ref),

where V stroke ref is a reference stroke volume, V stroke is a subject's actual stroke volume, PEV ref is a reference pulmonary exchange volume, and PEV is the subject's measured pulmonary exchange volume.