Patent ID: 11938348
Assignee: GENERAL ELECTRIC COMPANY
Field: Medical technology (Instruments)
Classification: CPC A | IPC A

Claim 16:
17. A modulation system comprising:
an energy application device comprising an ultrasound probe and configured to apply energy to a region of interest of a pancreas in a subject, the region of interest being a subregion of the pancreas comprising synapses between neuronal cells and respective non-neuronal cells; and
a controller configured to:
spatially select the region of interest of the pancreas;
focus the energy on the region of interest;
adjustably control application of the energy via the energy application device to the region of interest of the pancreas to induce activation at the synapses between neuronal cells and non-neuronal cells in the region of interest to selectively modulate or cause a change in concentration of one or more molecules of interest;
cause the ultrasound probe to operate in an imaging mode configured to acquire reference image data of the pancreas before the application of the energy and post-treatment image data of the pancreas after the application of the energy;
determine a displacement measurement of the pancreas based on a comparison of the reference image data and the post-treatment image data; and
modify a modulation parameter of the energy based on the displacement measurement being below a threshold displacement associated with the change in concentration of the one or more molecules.