Patent ID: 11918569
Assignee: POXEL SA
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 0:
1. A method of treating a disorder selected from the group consisting of adrenoleukodystrophy (ALD), nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH), the method comprising administering to a patient in need thereof a therapeutically effective amount of a deuterium-enriched compound of formula IIa or IIb or a pharmaceutically acceptable salt form thereof:, , wherein:
R2, R3, R4, R5, R6, R7, R8, R9, R12, R13, and R14 are H;
R1 is H or D, provided that the abundance of deuterium in R1 is at least 90%;
Z is H or D, provided that the abundance of deuterium in Z is at least 30%;
R10 is H and R11 is OH or OD; or
R10 and R11 are taken together with the carbon to which they are attached to form a carbonyl;
RA is ethyl;
wherein the compound has an enantiomeric excess, with respect to the C—Z carbon, of at least 5%.