Patent ID: 11884707
Assignee: REGENERON PHARMACEUTICALS, INC.
Field: Measurement (Instruments)
Classification: CPC C  G  A | IPC A  C  G

Claim 12:
13. A binding agent that specifically binds IDO1, wherein the binding agent comprises a first ligand having affinity for a first epitope on IDO1, a second ligand having affinity for a second epitope on IDO1, and a linker covalently connecting the first ligand to the second ligand, wherein the first and second ligands each comprises a cyclic peptide,
wherein the cyclic peptide of the first ligand has an amino acid sequence selected from one of the groups (1), (2), or (3) and wherein the cyclic peptide of the second ligand has an amino acid sequence selected from one of the two groups from which the amino acid sequence of the cyclic peptide of the first ligand was not selected,
wherein group (1) consists of:
(a) X1rf(Me-Trp)X2, wherein X1 and X2 are independently D-Ala, D-Arg, D-Asn, D-Asp, D-Glu, Gly, D-His, D-Leu, D-Lys, D-Phe, D-Pro, D-Ser, D-Thr, D-Trp, D-Tyr, or D-Val or is not present;
(b) nsfr(Me-Trp); and
(c) wyrX3y, wherein X3 is D-Ala or is not present, wherein group (2) consists of:
(d) rys(Me-Trp)r;
(e) X4lf(Me-Trp)(F-Phe), wherein X4 is D-Ala, D-Arg, D-Asn, D-Asp, D-Glu, Gly, D-His, D-Leu, D-Lys, D-Phe, D-Pro, D-Ser, D-Thr, D-Trp, D-Tyr, or D-Val or is not present;
(f) nlw(Me-Trp)r; and
(g) sX5ww(F-Phe), wherein X5 is D-Ala, D-Arg, D-Asn, D-Asp, D-Glu, Gly, D-His, D-Leu, D-Lys, D-Phe, D-Pro, D-Ser, D-Thr, D-Trp, D-Tyr, or D-Val or is not present, and

wherein group (3) consists of:
(h) rffyl; and
(i) nsh(F-Phe)r.