Patent ID: 11952681
Assignee: ADAGENE, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 32:
33. An activatable antibody comprising:
a first polypeptide comprising, from N-terminus to C-terminus, a masking moiety (MM), a cleavable moiety (CM), and an antibody light chain variable region (VL), and
a second polypeptide comprising an antibody heavy chain variable region (VH);
wherein the MM comprises an amino acid sequence selected from the group consisting of SEQ ID NOS: 79-85;
wherein the CM comprises at least a first cleavage site and a first flexible linker (L1);
wherein:
(i) the VH comprises an HVR-H1 comprising the amino acid sequence of SEQ ID NO: 65, an HVR-H2 comprising the amino acid sequence of SEQ ID NO: 66, and an HVR-H3 comprising the amino acid sequence of SEQ ID NO: 67; and
(ii) the VL comprises an HVR-L1 comprising the amino acid sequence of SEQ ID NO: 68, an HVR-L2 comprising the amino acid sequence of SEQ ID NO: 69, and an HVR-L3 comprising the amino acid sequence of SEQ ID NO: 70; and

wherein the activatable antibody binds to human CD137 via the VH and the VL when the CM is cleaved.