Patent ID: 11858925
Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A compound of formula (I):, or a pharmaceutically acceptable salt thereof, wherein:
R1 is selected from heterocyclyl, heterocyclylalkyl, heteroaryl, heteroarylalkyl, aryl, arylalkyl, cycloalkyl, cycloalkylalkyl, hydroxy, alkoxy, thioalkyl, halogen, haloalkyl, carboxy, acyl, amido, cyano, and sulfonyl;
X is —C(O)—, —C(S)—, —CH2—, or —SO2—, or is absent;
Y is —NRa—;
Ra is selected from hydrogen, alkyl, haloalkyl, heteroalkyl, cycloalkyl, hydroxyalkyl, and aminoalkyl, or Ra is taken together with the nitrogen atom to which it is attached to form a fused ring with A, or Ra and R1 together with the atoms to which they are attached together form an optionally substituted heterocyclic ring;
Z is absent or is —CRbRc—;
Rb and Rc are each independently selected from hydrogen and alkyl;
A is a five-membered heteroaryl;
Q is a four-, five-, or six-membered heterocyclyl;
R2 is selected from hydrogen, halo, alkyl, amino, and hydroxy; and
R3 is a group of formula:, wherein: B is a 5-membered monocyclic heteroaryl having 1 or 2 heteroatoms independently selected from N and S; J is absent; C is selected from aryl, heteroaryl, and heterocyclyl; m is 0 or 1; n is 0, 1, 2, or 3; Rg is C1-C6 alkyl; and each Rh is independently selected from alkyl, halo, haloalkyl, amino, aminoalkyl, amido, amidoalkyl, sulfonamido, sulfonamidoalkyl, acyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, cycloalkyl, and cycloalkylalkyl;

wherein each alkyl, alkenyl, alkynyl, aryl, arylalkyl, heteroalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, heterocyclyl, and heterocyclylalkyl is independently optionally substituted with 1, 2, 3, 4, or 5 substituents,
with the proviso that when Z is —CRbRc—, R1 is not cycloalkyl.