Patent ID: 11944837
Assignee: ASHA MEDICAL, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 0:
1. A system for treating cancer cells in a target body area of a patient by modifying a cancer microenvironment (TME) comprising:
an alternating polarity (AP) magnetic field generator;
one or more AP electromagnetic coils coupled to the AP magnetic field generator and adapted to be coupled to the target body area, wherein the one or more AP electromagnetic coils are adapted to be energized by an electrical signal from the AP magnetic field generator to generate and apply to the target body area an AP magnetic field having a first frequency of 0.1-500 kHz and a field strength of 0.2-5 mT;
a controller to control the AP magnetic field generator, the one or more AP electromagnetic coils, and at least one of the first frequency and the field strength;
wherein the AP magnetic field is adapted to modify a cancer microenvironment (TME) surrounding the cancer cells by at least one of:
increasing a number of M1 macrophages in the TME surrounding the cancer cells;
decreasing a number of M2 macrophages in the TME surrounding the cancer cells; and
decreasing one of a number or a concentration of myloid-derived suppressor cells (MDSCs) in the TME surrounding the cancer cells.