Patent ID: 11919949
Assignee: ELASMOGEN LTD
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC C

Claim 0:
1. A multi-domain specific binding molecule comprising at least two VNAR domains which bind to the same or different epitopes of at least one specific antigen, and a spacer sequence located between the at least two VNAR domains, wherein the spacer sequence has independent functionality which is exhibited in the binding molecule and wherein the spacer sequence is derived from an immunoglobulin Fc region, wherein each of the at least two VNAR domains has the structure FW1-CDR1-FW2-HV2-FW3a-HV4-FW3b-CDR3-FW4 in the N- to C-terminal direction,
wherein at least one of the VNAR domains is a TNF-alpha specific VNAR binding domain comprising the following CDRs and hyper-variable regions (HV):
CDR1: HCATSS (SEQ ID NO: 68) or NCGLSS (SEQ ID NO: 69) or NCALSS (SEQ ID NO: 70);
HV2: TNEESISKG (SEQ ID NO: 71);
HV4: SGSKS (SEQ ID NO: 72) or EGSKS (SEQ ID NO: 73);
CDR3: ECQYGLAEYDV (SEQ ID NO: 1) or SWWTQNWRCSNSDV (SEQ ID NO: 6) or YIPCIDELVYMISGGTSGPIHDV (SEQ ID NO: 11).