Patent ID: 11872092
Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 0:
1. A method of imaging a tissue implantation device in a biological environment comprising:
disposing two or more tissue implantation devices in a biological environment, the tissue implantation devices each comprising a capsule and a population of ultrasound-switchable fluorophores incorporated in the capsule, the population of ultrasound-switchable fluorophores having a switching threshold in the biological environment;
exposing the biological environment to an ultrasound beam to form an activation region within the biological environment;
switching the ultrasound-switchable fluorophores in the activation region from an off state to an on state;
exciting the ultrasound-switchable fluorophores in the activation region with a beam of electromagnetic radiation;
detecting light emitted by the ultrasound-switchable fluorophores;
correlating a size, shape, position, orientation, or any combination thereof, of the two or more tissue implantation devices in the biological environment based on the detected light emitted by the ultrasound-switchable fluorophores; and
resolving the two or more tissue implantation devices based on the detected light emitted by the ultrasound-switchable fluorophores,
wherein the two or more tissue implantation devices are spatially resolved from each other in at least an xy plane.