Patent ID: 11890339
Assignee: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 3:
4. The immunogen of claim 1, wherein:
the cysteine substitutions at NiV F positions 104 and 114 are L104C and 1114C substitutions;
the cysteine substitutions at NiV F positions 114 and 426 are 1114C and I426C substitutions;
the proline substitution at NiV F position 191 is a S191P substitution;
the phenylalanine substitution at NiV F position 172 is a L172F substitution;
the glycine substitution at NiV F position 70 is a Q70G substitution; and/or
the deletion of NiV F positions 102-113 with positions 101 and 114 linked by a glycine-serine linker having the sequence GSG.