Patent ID: 11970538
Assignee: COMPASS THERAPEUTICS LLC
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. An antibody or antigen-binding fragment thereof that binds PD-1 and comprises:
(a) a heavy chain variable region comprising (i) a CDRH1 comprising the amino acid sequence of SEQ ID NO: 70 (FTFX1X2YAX3X4, wherein X1=S, R, G, or N; X2=D, S, N, A, R, or G; X3=M or L; X4=S, L, or N); (ii) a CDRH2 comprising the amino acid sequence of SEQ ID NO: 71; and (iii) a CDRH3 comprising the amino acid sequence of SEQ ID NO: 72 (ARGLDFIVGX5TGNDY, wherein X5=A, Y, or R); and
(b) a light chain variable region comprising: (i) a CDRL1 comprising the amino acid sequence of SEQ ID NO: 9; (ii) a CDRL2 comprising the amino acid sequence of SEQ ID NO: 5; and (iii) a CDRL3 comprising the amino acid sequence of SEQ ID NO: 10.