Patent ID: 11897876
Assignee: GENZYME CORPORATION
Field: Organic fine chemistry (Chemistry)
Classification: CPC C  A | IPC C

Claim 5:
6. A compound of the formula I according to claim 1, wherein the compound of formula I is selected from
3-fluoro-5-[(3S)-2-[1-[6-(2-methylimidazol-1-yl)pyrimidin-4-yl]piperidine-4-carbonyl]isoxazolidin-3-yl]benzonitrile;
3-fluoro-2-methyl-5-[(3S)-2-[1-[6-(2-methylimidazol-1-yl)pyrimidin-4-yl]piperidine-4-carbonyl]isoxazolidin-3-yl]benzonitrile;
3-fluoro-5-[(3S)-2-[1-[6-(2-methylpyrazol-3-yl)pyrimidin-4-yl]piperidine-4-carbonyl]isoxazolidin-3-yl]benzonitrile;
[(3S)-3-(3,5-difluorophenyl)isoxazolidin-2-yl]-[1-[6-(2-methylpyrazol-3-yl)pyrimidin-4-yl]-4-piperidyl]methanone;
[(3S)-3-(3-chloro-5-fluoro-phenyl)isoxazolidin-2-yl]-[1-[6-(2-methylpyrazol-3-yl)pyrimidin-4-yl]-4-piperidyl]methanone;
3-fluoro-5-[(3S)-2-[1-[6-(3-methyl-1H-pyrazol-4-yl)pyrimidin-4-yl]piperidine-4-carbonyl]isoxazolidin-3-yl]benzonitrile;
3-[(3S)-2-[1-[6-(4-cyclopropyl-2-methyl-imidazol-1-yl)pyrimidin-4-yl]piperidine-4-carbonyl]isoxazolidin-3-yl]-5-fluoro-benzonitrile;
5-[(3S)-2-[1-[6-(4-cyclopropyl-2-methyl-imidazol-1-yl)pyrimidin-4-yl]piperidine-4-carbonyl]isoxazolidin-3-yl]-3-fluoro-2-methyl-benzonitrile;
3-[(3S)-2-[1-[6-(2,5-dimethylpyrazol-3-yl)pyrimidin-4-yl]piperidine-4-carbonyl]isoxazolidin-3-yl]-5-fluoro-benzonitrile;
3-fluoro-5-[(3S)-2-[1-[6-(3-methyl-1,2,4-triazol-1-yl)pyrimidin-4-yl]piperidine-4-carbonyl]isoxazolidin-3-yl]benzonitrile;
3-fluoro-5-[(3S)-2-[1-[6-(5-methyl-1,2,4-triazol-1-yl)pyrimidin-4-yl]piperidine-4-carbonyl]isoxazolidin-3-yl]benzonitrile;
3-fluoro-5-[(3S)-2-[1-[6-(3-methyltriazol-4-yl)pyrimidin-4-yl]piperidine-4-carbonyl]isoxazolidin-3-yl]benzonitrile;
3-fluoro-5-[(3S)-2-[1-[5-fluoro-6-(2-methylimidazol-1-yl)pyrimidin-4-yl]piperidine-4-carbonyl]isoxazolidin-3-yl]benzonitrile;
3-fluoro-5-[(3S)-2-[1-[5-fluoro-6-(4-methylpyrazol-1-yl)pyrimidin-4-yl]piperidine-4-carbonyl]isoxazolidin-3-yl]-2-methyl-benzonitrile; and
[(3S)-3-(3,5-difluorophenyl)isoxazolidin-2-yl]-[1-[5-fluoro-6-(2-methylpyrazol-3-yl)pyrimidin-4-yl]-4-piperidyl]methanone;
or a pharmaceutically acceptable salt, solvate, or stereoisomer thereof.