Patent ID: 11957748
Assignee: 21C BIO
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 1:
2. The method for preventing according to claim 1, wherein the interferon-alpha blocking agent is selected from the group of: an agent neutralizing circulating alpha interferon, an agent blocking interferon-alpha signaling, an agent depleting IFN-α producing cells, and/or an agent blocking IFN-α production, wherein the agent neutralizing circulating alpha interferon is selected from the group comprising active anti-IFN-α vaccine including antiferon or passive anti-IFN-α vaccine including anti-IFN-α antibodies or anti-IFN-α hyper-immune serum, wherein the blocking agent of interferon-alpha signaling is selected from the group of anti-type I interferon R1 or R2 antibodies or from interferon-alpha endogenous regulators including SOSC1 or aryl hydrocarbon receptors, wherein the agent depleting IFN-α producing cells is an agent depleting plasmacytoid dendritic cells (pDCs), and wherein the agent blocking IFN-α production is an agent blocking the production of IFN-α by pDCs.