Patent ID: 11932871
Assignee: THE MEDICAL RESEARCH, INFRASTRUCTURE AND HEALTH SERVICES FUND OF THE TEL AVIV MEDICAL CENTER
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A method of culturing T cells, the method comprising culturing T cells in a culture vessel in the presence of a T cell stimulator, an exogenous CCL21 and an exogenous ICAM1, thereby culturing the T cells, wherein each of said CCL21 and ICAM1 are immobilized to a solid support, wherein said T cell stimulator is an antigen-specific stimulator comprising a dendritic cell loaded with an antigen, wherein said immobilized CCL21 and ICAM1 are attached to said culture vessel, and wherein said T cells comprise engineered T cells transduced with a nucleic acid encoding a T cell receptor (TCR) or a chimeric antigen receptor (CAR).