Patent ID: 11903965
Assignee: HDL THERAPEUTICS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  G | IPC A

Claim 7:
8. A method for preserving modified high density lipoproteins for administration to a patient, comprising:
obtaining a batch of delipidated plasma comprising the modified high density lipoproteins by connecting at least one person to a device for withdrawing blood, withdrawing blood containing blood cells from the at least one person, separating the blood cells from the blood to yield a blood plasma fraction containing high density lipoproteins and low density lipoproteins, delipidating the high density lipoproteins using a solvent, separating out the low density lipoproteins, and collecting the delipidated plasma with the modified high density lipoproteins;
testing a portion of the batch of the delipidated plasma to determine a first concentration of the modified density lipoprotein in the delipidated plasma;
preserving the batch of the delipidated plasma;
after a period of time, preparing the preserved delipidated plasma for administration to the patient, wherein the period of time ranges from one week to three years;
testing a portion of the prepared preserved delipidated plasma by acquiring a first amount of the preserved delipidated plasma, determining an amount of modified high density lipoprotein in the preserved delipidated plasma using gel testing, determining if the first concentration of the modified high density lipoprotein has decreased below an acceptable threshold level, wherein, if the first concentration has decreased below an acceptable threshold level, concluding that the prepared preserved delipidated plasma is not suitable for administration and wherein, if the first concentration is at or above the acceptable threshold level, concluding that the prepared preserved delipidated plasma is suitable for administration; and
based on concluding that the prepared preserved delipidated plasma is suitable for administration, administering the prepared preserved delipidated plasma to the patient.