Patent ID: 11884720
Assignee: AMGEN RESEARCH (MUNICH) GMBH
Field: Biotechnology (Chemistry)
Classification: CPC C  A | IPC C

Claim 0:
1. A bispecific antibody construct comprising a first binding domain which binds to human mesothelin (MSLN) on the surface of a target cell and a second binding domain which binds to human CD3 epsilon on the surface of a T cell, wherein the first binding domain comprises a VH region comprising CDR-H1, CDR-H2 and CDR-H3 and a VL region comprising CDR-L1, CDR-L2 and CDR-L3, wherein said CDR-H1, CDR-H2, CDR-H3, CDR-L1, CDR-L2, and CDR-L3 comprise the amino acid sequences selected from the group consisting of:
a) the amino acid sequences of SEQ ID NO: 161 (CDR-H1), SEQ ID NO: 162 (CDR-H2), SEQ ID NO: 163 (CDR-H3), SEQ ID NO: 164 (CDR-L1), SEQ ID NO: 165 (CDR-L2), and SEQ ID NO: 166 (CDR-L3);
b) the amino acid sequences of SEQ ID NO: 171 (CDR-H1), SEQ ID NO: 172 (CDR-H2), SEQ ID NO: 173 (CDR-H3), SEQ ID NO: 174 (CDR-L1), SEQ ID NO: 175 (CDR-L2), and SEQ ID NO: 176 (CDR-L3);
c) the amino acid sequences of SEQ ID NO: 181 (CDR-H1), SEQ ID NO: 182 (CDR-H2), SEQ ID NO: 183 (CDR-H3), SEQ ID NO: 184 (CDR-L1), SEQ ID NO: 185 (CDR-L2), and SEQ ID NO: 186 (CDR-L3);
d) the amino acid sequences of SEQ ID NO: 191 (CDR-H1), SEQ ID NO: 192 (CDR-H2), SEQ ID NO: 193 (CDR-H3), SEQ ID NO: 194 (CDR-L1), SEQ ID NO: 195 (CDR-L2), and SEQ ID NO: 196 (CDR-L3); and
e) the amino acid sequences of SEQ ID NO: 201 (CDR-H1), SEQ ID NO: 202 (CDR-H2), SEQ ID NO: 203 (CDR-H3), SEQ ID NO: 204 (CDR-L1), SEQ ID NO: 205 (CDR-L2), and SEQ ID NO: 206 (CDR-L3), and
wherein the second binding domain comprises a heavy chain variable (VH) region and a light chain variable (VL) region.