Patent ID: 11925705
Assignee: THE CURATORS OF THE UNIVERSITY OF MISSOURI
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 0:
1. A method of forming a loaded nanogel, the method comprising micromixing a polymer, a crosslinker, a target, and a solvent system in a multi-inlet vortex mixer until the loaded nanogel is formed, wherein:
said polymer is chosen from polyamidoamine dendrimers, metal-decorated polyamidoamine dendrimers, polyethylenimine, chitosan, chitosan derivatives, amine-functionalized multi-armed polyethylene glycol, N-hydroxysuccinimide functionalized hyaluronic acid, sulfo-N-hydroxysuccinimide functionalized hyaluronic acid, N-hydroxysuccinimide functionalized multi-armed polyethylene glycol, sulfo-N-hydroxysuccinimide functionalized multi-armed polyethylene glycol, N-hydroxysuccinimide functionalized polyacrylic acid, sulfo-N-hydroxysuccinimide functionalized polyacrylic acid, or combinations thereof;
said crosslinker is chosen from bis-(N-hydroxysuccinimide) functionalized polyethylene glycols, bis-amine functionalized polyethylene glycols, bis-(N-hydroxysuccinimide) functionalized thioketal, disulfide (N-hydroxysuccinimide), cysteamine, 3,3′-dithiodipropionic acid di(N-hydroxysuccinimide ester), cis-aconitic anhydride functionalized polyethylene glycol, or combinations thereof; and
said target is chosen from drugs, genes, proteins, plasmids, targeting ligands, or combinations thereof.