Patent ID: 11911719
Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
Field: Chemical engineering (Chemistry)
Classification: CPC B  A | IPC A  B

Claim 11:
12. A method of processing a cake comprising an active pharmaceutical ingredient, the method comprising:
rotating an edge comprising a plurality of protrusions extending toward a filtration medium such that the edge sweeps at least a portion of the filtration medium in a clockwise direction; and
rotating the edge such that the edge sweeps at least a portion of the filtration medium in a counterclockwise direction;
wherein the rotating in the clockwise direction and/or the counterclockwise direction breaks up agglomerates and/or lumps formed from the cake comprising the active pharmaceutical ingredient, the agglomerates and/or lumps having maximum cross-sectional dimensions of greater than or equal to 100 micrometers and less than or equal to 10 millimeters, forming powder from the cake;
wherein at least 90%, by mass, of the powder has a particle size of less than 500 micrometers;
wherein the edge comprises at least 20 protrusions having a protruding dimension of greater than or equal to 1 mm and less than or equal to 2 cm; and
wherein the at least 20 protrusions have an average spacing of greater than or equal to 1 mm and less than or equal to 1 cm.