Patent ID: 11939367
Assignee: PFIZER INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A  Y | IPC A  C

Claim 8:
9. A method of increasing BTLA signaling in cells expressing BTLA wherein BTLA, agonizing BTLA in cells expressing BTLA, inhibiting T cell signaling, inhibiting B cell signaling, reducing ERK1/2 phosphorylation in cells expressing BTLA, reducing ZAP70/Syk phosphorylation in cells expressing BTLA, inducing total cellular phosphorylation in cells expressing BTLA, or inducing phosphorylation of SHP2 in cells expressing BTLA, comprising administering a fusion protein to a subject in need thereof,
wherein the fusion protein comprises a herpesvirus entry mediator (HVEM) protein and an Fc protein, wherein the HVEM protein comprises amino acids 39-184 of SEQ ID NO: 2, and
wherein amino acids 39-184 of SEQ ID NO: 2 contain mutations comprising S58R, G68T, L70W, and L90A with reference to SEQ ID NO: 2.