Patent ID: 11903381
Assignee: TRANSMEDICS, INC.
Field: Biotechnology (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 26:
27. A system for perfusing an ex-vivo liver, the system comprising:
a pump configured to pump a perfusion fluid through a perfusion circuit, the pump in fluid communication with a hepatic artery interface and a portal vein interface;
a controller configured to cause the system to:
provide, via the pump and the hepatic artery interface, the perfusion fluid to a hepatic artery of the ex-vivo liver at a flow rate between 0.25-1 L/min; and
provide, via the pump and the portal vein interface, the perfusion fluid to a portal vein of the ex-vivo liver at a flow rate between 0.75-2 L/min;

an oxygenator;
a clamp adapted to be positioned between the pump and the portal vein interface, the clamp configured to be usable to control the pressure of the perfusion fluid provided to the hepatic artery;
a heater configured to maintain a temperature of the perfusion fluid at between about 34°-37° Celsius;
an inferior vena cava interface in fluid communication with an inferior vena cava of the ex-vivo liver; and
a bile container configured to collect bile produced by the ex-vivo liver.