Patent ID: 11969253
Assignee: SETPOINT MEDICAL CORPORATION
Field: Medical technology (Instruments)
Classification: CPC A | IPC A

Claim 11:
12. An implantable microstimulator device for treating chronic inflammation, the device comprising:
a hermetically sealed capsule body;
at least two electrically conductive capsule regions, wherein each region electrically connects to an electrode, wherein the electrodes are configured for applying stimulation to a vagus nerve to modulate an inflammatory reflex and for sensing electrical activity from the vagus nerve;
a power source within the sealed capsule body; and
a controller within the sealed capsule body configured to:
sense electrical activity on the vagus nerve a patient during a baseline period from the microstimulator device implanted around the cervical portion of the vagus nerve;
sense electrical activity on the vagus nerve during a course of treatment at various levels of inflammation, including when accommodation is suspected of reducing an efficacy of the treatment;
determine a neural signature for each of a plurality of inflammatory states based on the sensed electrical activity from the baseline period and the sensed electrical activity at the various levels of inflammation to determine a sensed electrical activity relationship to a state of accommodation, wherein determining the neural signature for each of the plurality of inflammatory states includes characterizing a neural recording of the vagus nerve;
store the neural signature for each of the plurality of inflammatory states;
sense electrical activity on the vagus nerve at a first time period;
determine an inflammatory state of the patient based on a comparison of a particular sensed electrical activity to at least one of the stored neural signatures; and
deliver a therapeutic dose to the patient by stimulating the vagus nerve while controlling one or more characteristic of stimulation of the microstimulator device based on the determined inflammatory state, including the state of accommodation, wherein the one or more characteristic of stimulation is selected from the group consisting of: duration, intensity, frequency, on-time and off-time.