Patent ID: 11919972
Assignee: REGENERON PHARMACEUTICALS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  G  A | IPC A  C  G

Claim 0:
1. A cyclic peptide having the following structure (I):, , or a salt, tautomer, prodrug or stereoisomer thereof, wherein:
L1 and L2 are each individually optionally substituted linker moieties, each linker moiety optionally comprising a linkage to a solid support, a linkage to a reporter moiety, a linkage to a peptide ligand, a linkage to an azide or alkyne moiety, or combinations thereof;
G is a triazole;
M is absent or methionine;
R is H, -L3-A or —C(═O)-L3-A, where L3 is a linker moiety and A is an alkyne, azide, or a bond to a peptide ligand;
R1 is H or C1-C6 alkyl;
y1 and y2 are each individually 0 or 1; and
SEQ is an amino acid sequence comprising from 2 to 20 amino acids selected from the group consisting of: L-alanine, L-glycine, L-leucine, L-isoleucine, L-valine, L-phenylalanine, L-tryptophan, L-arginine, L-histidine, L-lysine, L-aspartic acid, L-glutamic acid, L-asparagine, L-glutamine, L-serine, L-threonine, L-tyrosine, L-proline, D-alanine, D-glycine, D-leucine, D-isoleucine, D-valine, D-phenylalanine, D-tryptophan, D-arginine, D-histidine, D-lysine, D-aspartic acid, D-glutamic acid, D-asparagine, D-glutamine, D-serine, D-threonine, D-tyrosine, D-proline, Cyclopropyl Alanine (CyA), Methyl Leucine (MeL), Methyl Valine (MeV), Allylglycine, Methyl Tryptophan (MT), Thiazolyl Alanine (Thz), 2-Naphthyl Alanine (Nap), O-Methyl Tyrosine (OMY), 4-Fluorophenyl Alanine (FP), 4-Cyano Phenylalanine (CN—F), 4-Phenyl Phenylalanine (PhF), 4-Bromo Phenylalanine (Br—F), 4-Pyridyl Alanine (PyrA), 4-Methyl Phenylalanine (Me-F), O-Phenyl Tyrosine (OPhY), β-Phenylalanine (BPhA), Dimethyl Lysine (DMK), 2-Methoxy Pyridylalanine (MeOPyr), Piperazinecarboxylic acid, N-Methyl d-valine (N-Me-v), N-Methyl d-alanine (N-Me-a), Aminocyclobutyl carboxylic acid (ACBC), Aminocyclohexyl carboxylic (ACHC), α-Methyl Alanine (AMA), Morpholinecarboxylic acid, Tetrazoyl Alanine (Ttz), β-Alanine (BAla), and Azetidine carboxylic acid, and
wherein at least one amino acid in SEQ is CyA, MeL, MeV, Allylglycine, MT, Thz, Nap, OMY, FP, CN—F, PhF, Br—F, PyrA, Me-F, OPhY, BPhA, DMK, MeOPyr, Piperazinecarboxylic acid, N-Me-v, N-Me-a, ACBC, ACHC, AMA, Morpholinecarboxylic acid, Ttz, BAla, or Azetidine carboxylic acid.