Patent ID: 11945867
Assignee: AUTOLUS LIMITED
Field: Measurement (Instruments)
Classification: CPC C  G | IPC C  G

Claim 4:
5. A method for treating a T-cell malignancy in a subject, which comprises the following steps:
a) investigating the clonality of the T-cell malignancy comprising detecting the expression of TRBC2 by malignant T cells from said subject using a polyclonal antibody which binds the T-cell receptor constant region 2 (TRBC2) intracellular portion having the sequence VKRKDSRG (SEQ ID NO: 1) and which does not cross-react with T-cell receptor constant region 1 (TRBC1), to establish whether malignant T cells from the subject express TRBC2; and
b) administering a TRBC2-specific therapeutic agent to a subject having a TRBC2-expressing T-cell malignancy, wherein the TRBC2-specific therapeutic agent is a therapeutic antibody, an antibody-drug conjugate, a bispecific T-cell engager, or a chimeric antigen receptor (CAR)-T cell composition.