Patent ID: 11958899
Assignee: nan
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC C

Claim 0:
1. A recombinant anti-C1s antibody or an antigen-binding fragment thereof that is capable of specifically binding to human C1s and inhibiting C1s, comprising a heavy chain variable region (VH) comprising three heavy chain complementarity determining regions (HC CDRs) and a light chain variable region (VL) comprising three light chain complementarity determining regions (LC CDRs), selected from:
(a) the VH comprising an HC CDR1 having the amino acid sequence GFTFSNYFMN (SEQ ID NO: 129), an HC CDR2 having the amino acid sequence EIRLKFTNYATHYA(E/D)SV(EX)G (SEQ ID NO: 130), and an HC CDR3 having the amino acid sequence DYGSRN(G/A)YFDY (SEQ ID NO: 131), and the VL comprising an LC CDR1 having the amino acid sequence RSSKSLLHSNGNTFLY (SEQ ID NO: 132), an LC CDR2 having the amino acid sequence RMSNLAS (SEQ ID NO: 133), and an LC CDR3 having the amino acid sequence MQHLEYPYT (SEQ ID NO: 134), and
(b) the VH comprising an HC CDR1 having the amino acid sequence GFNIKEYYMH (SEQ ID NO: 135), an HC CDR2 having the amino acid sequence WIDPEN(G/A)D(T/A)IY(D/A)(P/Q)KFQG (SEQ ID NO: 136), and an HC CDR3 having the amino acid sequence SRLFFAY (SEQ ID NO: 137), and the VL comprising an LC CDR1 having the amino acid sequence ASQDVRTA(V/L)D (SEQ ID NO: 138), an LC CDR2 comprising the amino acid sequence SASYRY(T/S) (SEQ ID NO: 139), and LC CDR3 comprising the amino acid sequence QQQYTTPYT (SEQ ID NO: 140).