Patent ID: 11925695
Assignee: LANTHEUS MEDICAL IMAGING, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 12:
13. A method of ultrasound contrast imaging a subject comprising
a) controlling calcium and/or magnesium concentration of a phospholipid solution to less than 0.7 ppm, wherein the phospholipid solution comprises one or more phospholipids in propylene glycol, and combining the phospholipid solution with an aqueous solution to form a phospholipid suspension that maintains at least 90% of an individual phospholipid content upon filtration through a 0.2 micron filter,
b) activating the phospholipid suspension with a perfluorocarbon gas to form lipid-encapsulated gas microspheres,
c) administering the lipid-encapsulated microspheres to a subject, and
d) obtaining an ultrasound image of the subject.