Patent ID: 11925463
Assignee: LCM BIOSENSOR TECHNOLOGIES, INC.
Field: Medical technology (Instruments)
Classification: CPC A | IPC A

Claim 25:
26. A device for monitoring blood glucose levels, comprising:
a heat and waterproof applicator having upper and inner surfaces and adapted to be applied on skin with a dosed pressure so as to form a closed system in a local area of living tissue under the applicator,
sensors configured to measure physiological parameters,
sensors configured to measure climatic parameters,
a device configured to calibrate on a tissue site under the applicator,
an installation platform for fixing the climatic parameters sensors, fixed over the applicator,
at least one of an amplifier and an analog-digital converter installed on the upper surface of the applicator, and
a processor,
wherein the sensors configured to measure the climatic parameters are located on the installation platform, and the sensors configured to measure the physiological parameters are placed under the applicator,
wherein the device is configured such that signals from the sensors configured to measure the physiological parameters and the sensors configured to measure the climatic parameters are sequentially applied to inputs of the at least one of the amplifier and the analog-digital converter;
wherein the processor is configured to perform operations comprising:
measuring temporal dynamics of the physiological parameters in the local area of the living tissue under the applicator, including at least the temporal dynamics of:
osmotic pressure of an intercellular substance and/or an amount of water in an intercellular space of the tissue under the applicator;
temperature of a dermis under the applicator via radio thermometry or heat flow through a skin area under the applicator via a heat detector; and
elastic pressure of the tissue under the applicator,

measuring values of environmental climatic parameters before beginning the measurement of the temporal dynamics of the physiological parameters, including at least:
room temperature and relative humidity in a measurement room; and
atmosphere pressure,

measuring an external environment temperature or external heat flow through an enclosing structure between the measurement room and an external environment;
calculating a value of enthalpy, H, in a layer of the tissue under the applicator accounting for an influence of the climatic parameters, according to the formula:

H=H0(Tskin, Psensor)xθ(Troom, Text, RHroom, Patm),

where Tskin is the temperature of the dermis,
Psensor is the dosed pressure of the applicator on a skin surface,
Troom is the room temperature,
Text is an ambient air temperature behind the enclosing structure,
RHroom is the relative humidity in the measurement room, and
Patm is the atmospheric pressure; and
calculating changes in blood glucose level based on a thermodynamics equation that connects the enthalpy with thermodynamic variables or variables of a thermodynamic state.