Patent ID: 11945785
Assignee: BIOMEA FUSION, INC.
Field: Organic fine chemistry (Chemistry)
Classification: CPC C | IPC C

Claim 0:
1. A compound according to Formula (P6-I):, or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof,
wherein: each A1, A2, A3, and A4 is independently —C(R7);
each L1 and L3 is independently substituted or unsubstituted C1-C4 alkylene; and the substituents on each of C1-C4 alkylene are independently selected from one or more halo, CN, C1-4 alkyl, hydroxy, and C1-4 alkoxy;
R1 is H, halo, CN, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted alkoxy, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted cycloalkyl, or substituted or unsubstituted heterocycloalkyl, having 1-2 heteroatoms independently selected from nitrogen, oxygen, and sulfur; and the substituents on each of C1-6 alkyl, alkoxy, alkenyl, alkynyl, cycloalkyl and heterocycloalkyl are selected from one or more halo, CN, C1-4 alkyl, hydroxy, and C1-4 alkoxy;
R2b is independently H or C1-C4 alkyl;
R4 is —C(O)—C(R6a)═C(R6b)(R6c);
R5 is H, cycloalkyl, heterocycloalkyl, CN, halo, C1-6 alkyl, C1-6 alkoxy, or C1-6 alkylamino;
wherein
each of cycloalkyl, heterocycloalkyl, C1-6 alkyl, C1-6 alkoxy, and C1-6 alkylamino is unsubstituted or substituted with
one or more halo, CN, C1-4 alkyl, hydroxy, amino, alkylamino, dialkylamino, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, having 1-2 heteroatoms independently selected from nitrogen, oxygen, and sulfur; substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or C1-4 alkoxy; and
and the substituents on each of cycloalkyl, heterocycloalkyl, aryl, and heteroaryl are selected from one or more halo, CN, C1-4 alkyl, hydroxy, and C1-4 alkoxy;

each R6a and R6b is independently H, halo, CN, or C1-6 alkyl; or R6a and R6b are joined together to form a bond; R6c is H, halo, CN, or C1-6 alkyl, wherein the C1-6 alkyl is unsubstituted or substituted with one or more groups selected from substituted or unsubstituted amino, hydroxy, substituted or unsubstituted C1-6 alkoxy, and substituted or unsubstituted heterocycloalkyl having 1-2 heteroatoms independently selected from nitrogen, oxygen, and sulfur; and the substituents on each of amino, C1-6 alkoxy and heterocycloalkyl are selected from one or more halo, CN, C1-4 alkyl, hydroxy, and C1-4 alkoxy;
each R7 is independently H, halo, CN, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted alkoxy, or substituted or unsubstituted heterocycloalkyl, having 1-2 heteroatoms independently selected from nitrogen, oxygen, and sulfur; and the substituents on each of C1-6 alkyl, alkoxy and heterocycloalkyl are selected from one or more halo, CN, C1-4 alkyl, hydroxy, and C1-4 alkoxy.