Patent ID: 11939408
Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 11:
12. A method for making the compound of Formula (I) according to claim 1, or a pharmaceutically or cosmetically acceptable salt thereof, wherein the group comprising a hydrophobic moiety is of Formula (II):, wherein L is, m is 2-12;
each R2 is independently a fatty acid residue of the formula —C(O)R3, and
each R3 is C8-35 aliphatic;
the method comprising:
a) Providing a solution of unmodified hyaluronic acid (HA) of Formula (Ia):, or a salt thereof, wherein n is an integer from 1-20,000;

b) Contacting the solution with a diaminoalkyl compound under suitable conditions to obtain amine-functionalized HA, or a salt thereof;
c) Reacting the amine-functionalized HA or salt thereof with the compound of Formula (II) comprising —C(O)R3, to obtain the compound of Formula (I), or pharmaceutically or cosmetically acceptable salt thereof.