Patent ID: 11890380
Assignee: KING ABDULAZIZ UNIVERSITY
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 0:
1. A method of preparing a buccal tablet formulation, comprising
mixing a specified amount of solid dispersion of avanafil and PVP K-90, a specified amount of hydroxypropyl methylcellulose, a predetermined amount of sodium deoxycholate, porous silicon dioxide, and mannitol and then passing through mesh sieves to form a powder blend;
de-lumping a talc powder and magnesium stearate through a sieve and adding retrieved talc powder to the powder blend;
mixing the talc powder mixture and the powder blend to form a dry mixture; and
compressing the dry mixture to form a buccal tablet,
wherein the buccal tablet formulation comprises
100 mg of polyvinylpyrrolidone K-90 (PVP K-90);
36 mg of hydroxypropyl methylcellulose functioning in the buccal tablet formulation as a mucoadhesive polymer;
a sodium deoxycholate functioning in the buccal tablet formulation as a mucopenetration enhancer;
10 mg of porous silicon dioxide;
4 mg of mannitol; and
50 mg of avanafil,
wherein the PVP K-90 to avanafil ratio ranges from 2.3:1 to 1.7:1.