Patent ID: 11957123
Assignee: SPERMVITAL AS
Field: Basic materials chemistry (Chemistry)
Classification: CPC A | IPC A

Claim 11:
12. A kit for preparing a sustained release composition, the kit comprising a first container and a second container; the first container comprising an inactive crosslinker and either a first diffusion barrier or a second diffusion barrier; the second container comprising an ionically crosslinkable biocompatible polymer, an activator composition and optionally a material to be released; the first and/or second diffusion barrier allowing the activator composition and the inactive crosslinker to come in contact with each other at a delayed rate thereby ensuring delayed and sustained release of an active crosslinker;
wherein
the first container and/or the second container are of a size and form which allows the ionically crosslinkable biocompatible polymer to come into contact with the active crosslinker throughout the first container and/or the second container thereby ensuring that there is crosslinked biocompatible polymer throughout the first container and/or the second container;
the ionically crosslinkable biocompatible polymer is a divalent cation crosslinkable biocompatible polymer;
the term “active crosslinker” refers to ions for crosslinking the ionically crosslinkable biocompatible polymer;
the term “inactive crosslinker” refers to a compound that requires activation by the activator composition in order to be able to release ions for crosslinking the ionically crosslinkable biocompatible polymer;
and
wherein the first container comprises the first diffusion barrier; the inactive crosslinker in admixture with the first diffusion barrier is coated on inner surface of the first container;
wherein the first container comprises the first diffusion barrier; the inactive crosslinker and the first diffusion barrier are coated on the inner surface of the first container in separate layers thereby forming an inner surface layer and an intermediate layer, the intermediate layer comprising the inactive crosslinker;
wherein the first container comprises the second diffusion barrier and is made from a first polymer material; i) the inactive crosslinker, ii) the inactive crosslinker embedded or encapsulated within a second polymer material, or iii) a mixture of i) and ii) being extruded into the first polymer material during production of the first container; the second diffusion barrier being the first polymer material, the second polymer material or a combination thereof; or
wherein the first container comprises the second diffusion barrier and is made from a first polymer material; a third polymer material in admixture with i) the inactive crosslinker, ii) the inactive crosslinker embedded or encapsulated within a second polymer material, or iii) a mixture of i) and ii) being co-extruded with the first polymer material during production of the first container thereby forming an inner surface layer and an outer surface layer, the inner surface layer comprising the inactive crosslinker; and the second diffusion barrier being the second polymer material, the third polymer material or a combination thereof.