Patent ID: 11951141
Assignee: H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 0:
1. An adenovirus vector, wherein the adenovirus vector comprises:
a. a CMV promoter/enhancer inserted in a noncoding region upstream of the adenovirus E1 coding region;
b. a SV40 promoter/enhancer inserted in the adenovirus E3 region;
c. a deletion in part or all of the E3 coding region;
d. a E1A gene comprising a delta-24 deletion;
e. a E1B 55K deletion;
f. wherein the CMV promoter/enhancer is operably linked to a heterologous nucleic acid sequence encoding MEM40; and
g. wherein the SV40 promoter/enhancer is operably linked to a heterologous nucleic acid sequence encoding IFNβ.