Patent ID: 11960072
Assignee: INSCOPIX, INC.
Field: Computer technology (Electrical engineering)
Classification: CPC G | IPC G

Claim 0:
1. A method for providing multi-modal imaging using a plurality of microscopes, said method comprising:
a) receiving functional imaging data and structural imaging data from an adapter, the adapter comprising (i) a first microscope interface configured to optically couple a first microscope to an optical element that is in optical communication with an optical probe to provide the functional imaging data of a sample, and (ii) a second microscope interface configured to optically couple a second microscope to the optical element to provide the structural imaging data of the sample;
b) processing the functional imaging data, received from the adapter, to generate a first overlaid image;
c) processing the structural imaging data, received from the adapter, to generate a second overlaid image; d) co-registering the first overlaid image and the second overlaid image,
wherein said co-registering comprises aligning at least a portion of the first overlaid image and the second overlaid image based at least in part on a coordinate transformation,
wherein the coordinate transformation is derived based at least in part on a difference in sizes, shapes, positions, or orientations of a landmark feature present both in the first overlaid image and the second overlaid image;

e) using the difference in sizes, shapes, positions, or orientations the landmark feature in the first overlaid image and that in the second overlaid image to characterize an amount of distortion or warping of the landmark feature between the first overlaid image and the second overlaid image; and
f) generating a third overlay overlaid image from the first overlaid image and the second overlaid image after said co-registering.