Patent ID: 11972867
Assignee: UNIVERSITEIT MAASTRICHT
Field: Medical technology (Instruments)
Classification: CPC G | IPC G

Claim 3:
4. The method according to claim 3, wherein determining the hypoxia fraction comprises the steps of:
determining an average standard uptake value of the hypoxia staining marker in at least a region of the neoplasm;
determining, for each voxel of a plurality of voxels within the region, a standard uptake value of the respective voxel;
flagging the respective voxel as a hypoxic voxel if the standard uptake value of the voxel is greater than or equal to 1.4 times the average standard uptake value of the region; and
flagging the respective voxel as a non-hypoxic voxel if the standard uptake value of the voxel is smaller than 1.4 times the average standard uptake value of the region;

counting a total number of voxels and a total number of hypoxic voxels, and calculating the hypoxic fraction by dividing the total number of hypoxic voxels by the total number of voxels.