Patent ID: 11920131
Assignee: TORAY INDUSTRIES, INC.
Field: Biotechnology (Chemistry)
Classification: CPC C | IPC C

Claim 1:
2. The method according to claim 1, wherein the first single-stranded oligoRNA molecule is represented by formula (I) and the second single-stranded oligoRNA molecule is represented by formula (II):

5′-Xs-Lx1-Xa-3′  (I)

5′-Ya1-Ya2-Ya3-Lx2-Ys-3′  (II)

wherein Xs, Xa, Ya1, Ya2, Ya3, and Ys each represent one or more ribonucleotide residues,
Lx1 and Lx2 represent the first linker and the second linker, respectively,
Ya3 is complementary to Ys,
Xa-Ya1, which is generated by the ligation step, is complementary to Xs, and
Xa-Ya1-Ya2-Ya3, which is generated by the ligation step, comprises a gene expression-inhibiting sequence for the target gene.