Patent ID: 11908549
Assignee: KONINKLIJKE PHILIPS N.V.
Field: Computer technology (Electrical engineering)
Classification: CPC G | IPC G

Claim 16:
17. A method for inferring activity of a cellular signaling pathway using probabilistic modelling of target gene expressions, wherein the method comprises:
inferring the activity of the cellular signaling pathway in a medical subject based at least on expression levels of one or more target genes of the cellular signaling pathway measured in an extracted sample of the medical subject, wherein the inferring comprises:
determining an activity level of a transcription factor element in the extracted sample of the medical subject, the transcription factor element controlling transcription of the one or more target genes of the cellular signaling pathway, the determining being based at least in part on evaluating a Bayesian network according to the method of claim 1 relating expression levels of the one or more target genes of the cellular signaling pathway to the activity level of the transcription factor element; and
inferring the activity of the cellular signaling pathway in the medical subject based on the determined activity level of the transcription factor element in the extracted sample of the medical subject.