Patent ID: 11955209
Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
Field: Medical technology (Instruments)
Classification: CPC G | IPC G

Claim 12:
13. A system comprising:
a hardware processor, a computer readable memory, and a computer readable storage medium associated with a computing device;
program instructions to assign each of a plurality of entities to one of a plurality of treatment groups, wherein the plurality of entities are participants in a clinical trial; and
program instructions to, for each of the plurality of treatment groups:
for each of the entities in a group of the plurality of treatment groups, determine environmental features of an entity in real time during the clinical trial utilizing a deep learning environmental model outputting classified aspects of the entity's environment;
for each of the entities in the group of the plurality of treatment groups, obtain physiological measurements of the entity directly from a monitoring device of the entity during the clinical trial;
for each of the entities in the group of the plurality of treatment groups, determine an indication of how the entity is feeling in response to an active signal applied to the entity by analyzing digital images of the entity using a convoluted neural network;
for each of the entities in the group of the plurality of treatment groups, determine variables associated with the clinical trial;
for each of the entities in the group of the plurality of treatment groups, encode determined information about the entity during the clinical trial including the classified aspects of the entity's environment, the physiological measurements of the entity, the indication of how the entity is feeling, and the determined variables associated with the clinical trial, into a computer data structure as chromosomes using a genetic algorithm;
for each of the entities in the group of the plurality of treatment groups, iteratively update the chromosomes based on new determined information about the entity obtained during the clinical trial;
automatically determine one or more outlier chromosomes of the chromosomes;
automatically remove one or more outlier entities in the group of the plurality of treatment groups based on the determined outlier chromosomes;
determine a ranking of each of the entities in the group of the plurality of treatment groups based on a magnitude of values of the chromosomes corresponding to each of entity in the group;
for each group in the plurality of treatment groups, cross over portions of the encoded information of pairs of entities occupying adjacent positions in the ranking that describe aspects of the clinical trial to create new trial variables regarding aspects of the clinical trial, including dosage amounts of a medication; and
measure fitness of each of the entities in the group of the plurality of treatment groups based on their respective chromosomes,
wherein the program instructions are stored on the computer readable storage medium for execution by the hardware processor via the computer readable memory.