Patent ID: 11918592
Assignee: SYROS PHARMACEUTICALS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 8:
9. The compound of claim 6, wherein the compound is a compound of Formula II:, , or a pharmaceutically acceptable salt, stereoisomer, or isotopic form thereof, wherein:
ring B is optionally substituted;
ring C is optionally substituted;
X is N, CH, or C(R10), wherein R10 is halo or —P(O)(CH3)2;
Y is N or CH;
R1 is —OH, —CN, —C(O)NH2, or one of the following heteroaryl groups, wherein any heteroaryl portion of R1 is optionally substituted at up to two substitutable carbon atoms with a substituent independently selected from halo, —CN, —OH, —NH2, —NH(C1-C4 alkyl), —N(C1-C4 alkyl)2, C1-C4 alkyl, —O—(C1-C4 alkyl), —(C1-C4 alkylene)-O—(C1-C4 alkyl), and —S(O)2—(C1-C4 alkyl);
R2 is fluoro, chloro, —CN, or C1-C4 alkyl optionally substituted with fluoro;
R6 is hydrogen, —C1-C4 alkyl, —C(O)—(C1-C4 alkyl), —C(O)—(C1-C4 alkylene)-N(R7)2, —(C1-C4 alkylene)-O—(C1-C4 alkyl), —C(O)-aryl, or —S(O)2-aryl;
each R7 is, independently, halo, —CN, —OH, —NH2, —NH(C1-C4 alkyl), N(C1-C4 alkyl)2, —C1-C4 alkyl, —O—(C1-C4 alkyl), —(C1-C4 alkylene)-O—(C1-C4 alkyl) or —S(O)2—(C1-C4 alkyl);
m is 0, 1, 2, 3 or 4;
n is 0, 1, 2, 3 or 4;
o is 0, 1, 2, 3 or 4;
p is 0, 1, 2, 3 or 4;
wherein m+p does not equal 2;
each saturated heterocyclyl, cycloalkyl, or aryl is optionally substituted with up to four substituents independently selected from halo, —CN, —OH, —NH2, —NH(C1-C4 alkyl), N(C1-C4 alkyl)2, —C1-C4 alkyl, —O—(C1-C4 alkyl), —(C1-C4 alkylene)-O—(C1-C4 alkyl), and an optionally substituted phenyl; and
each C1-C4 alkyl and C1-C4 alkylene is optionally substituted with up to five substituents independently selected from halo, —CN, —OH, —NH2, —NH(unsubstituted C1-C4 alkyl), N(unsubstituted C1-C4 alkyl)2, and —O-(unsubstituted C1-C4 alkyl).