Patent ID: 11872324
Assignee: THE UNIVERSITY COURT OF THE UNIVERSITY OF GLASGOW
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 16:
17. A method of sustaining growth of stem cells or maintaining stem cells (maintaining stemness) comprising contacting a construct comprising:
a biocompatible substrate having a first surface, wherein the biocompatible substrate is selected from a synthetic polymer, a ceramic, a metal, an alloy and composites thereof, a material surface comprising an alkyl acrylate polymer deposited on said first surface, wherein the alkyl acrylate polymer is capable of supporting the formation of a physiological fibrillar network of FN adsorbed on its surface, fibronectin (FN) adsorbed on said material surface, wherein the FN forms a physiological fibrillar network of FN presenting colocalized growth factor binding domains and integrin binding domains, and a growth factor (GF) adsorbed on said FN, wherein said growth factor is capable of binding FNIII12-14,
with a stem cell under conditions capable of supporting stem cell viability or growth.