Patent ID: 11913944
Assignee: PROMEGA CORPORATION
Field: Measurement (Instruments)
Classification: CPC G | IPC G

Claim 0:
1. A composition comprising a PRG/HA probe comprising: a bioactive agent, a photoreactive group (PRG), a linker, and a haloalkane covalently connected in a single compound of the general structure:, wherein the bioactive agent is a small molecule,
wherein R is a covalent linkage,
wherein A is (CH2)n and n=4-10, wherein X is a halogen, wherein -A-X is a substrate for a dehalogenase,
wherein the Linker comprises a cleavable moiety flanked on one or both sides by alkylene or heteroalkylene chains, wherein the cleavable moiety is selected from the group consisting of a disulfide, tert-butyl carbamate, silyl ether, diazobenzene, 1,2-diol, and —C(O)OCH2CH═CHCH2OC(O)—, and wherein the alkylene or heteroalkylene chains comprise any suitable combination of functional groups selected from the group consisting of C1-6-alkylene, —O—, —(CH2)2O—, and —OC(O)NH— groups,
wherein the PRG is selected from the group consisting of:, and wherein Q is CH or N.