Patent ID: 11873292
Assignee: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
Field: Organic fine chemistry (Chemistry)
Classification: CPC C  A  Y | IPC A  C

Claim 4:
5. The compound of claim 1, wherein the compound is selected from the following group:, No.
Name
Structure

A1
Trans-2-(1-(phenylsulfonyl)indolin-5- yl)cyclopropylamine

 

A2
trans-N-phenyl-2-(1- (phenylsulfonyl)indolin-5- yl)cyclopropylamine

 

A3
trans-N-benzyl-2-(1- (phenylsulfonyl)indolin-5- yl)cyclopropylamine

 

A4
trans-N-(1-phenylethyl)-2-(1- (phenylsulfonyl)indolin-5- yl)cyclopropylamine

 

A5
trans-N-(4-dimethylamino-benzyl)-2-(1- (phenylsulfonyl)indolin-5- yl)cyclopropylamine

 

A6
trans-N-(4-pyridine-methylene)-2-(1- (phenylsulfonyl)indolin-5- yl)cyclopropylamine

 

A7
trans-N-(5-indolylmethylene)-2-(1- (phenylsulfonyl)indolin-5- yl)cyclopropylamine

 

A8
trans-N-(3-indolylmethylene)-2-(1- (phenylsulfonyl)indolin-5- yl)cyclopropylamine

 

A9
trans-N-(2-(1-(phenylsulfonyl)indolin- 5-yl)cyclopropyl)cyclohexylamine

 

A10
trans-N-cyclohexamethylene-2-(1- (phenylsulfonyl)indolin-5- yl)cyclopropylamine

 

A11
trans-N-butyl-2-(1- (phenylsulfonyl)indolin-5- yl)cyclopropylamine

 

A12
trans-2-(1-(phenylsulfonyl)indolin-5- yl)-N-((tetrahydro-2H-pyran-4- yl)methyl)cyclopropylamine

 

A13
trans-N-(2-(1-(phenylsulfonyl)indolin- 5-yl)cyclopropyl)tetrahydro-2H-pyran- 4-amine

 

A14
trans-N-(4-piperidinylmethylene)-2-(1- (phenylsulfonyl)indolin-5- yl)cyclopropylamine

 

A15
trans-N-(4-piperidinyl)-2-(1- (phenylsulfonyl)indolin-5- yl)cyclopropylamine

 

A16
trans-N-(4-piperidinylethyl)-2-(1- (phenylsulfonyl)porphyrin-5- yl)cyclopropylamine

 

A17
trans-N-(azetidin-3-ylmethyl)-2-(1- (phenylsulfonyl)indolin-5- yl)cyclopropylamine

 

A18
trans-4-((2-(1-(phenylsulfonyl)indolin- 5-yl)cyclopropylamino)methyl) cyclohexylamine

 

A19
trans-N1-(2-(1-(phenylsulfonyl)indolin- 5-yl)cyclopropyl)cyclohexane-1,4- diamine

 

A20
trans-N-(2-(1-(phenylsulfonyl)indolin- 5-yl)cyclopropyl)-7- azaspiro[3.5]nonane-2-amine

 

A21
trans-N-((4-methylpiperidin-4- yl)methyl)-2-(1- (phenylsulfonyl)indolin-5- yl)cyclopropylamine

 

A22
trans-4-((2-(1-(phenylsulfonyl)indolin- 5-yl)cyclopropylamino)methyl) piperidine-4-carboxylic acid

 

A23
trans-N-((1-methylpiperidin-4- yl)methyl)-2-(1- (phenylsulfonyl)indolin-5- yl)cyclopropylamine

 

A24
trans-N-((1-benzylpiperidin-4- yl)methyl)-2-(1- (phenylsulfonyl)indolin-5- yl)cyclopropylamine

 

A25
Trans-tert-butyl 4-((4-((2-(1- (phenylsulfonyl))indolin-5- yl)cyclopropylamino)methyl) piperidin-1-yl)methyl)benzoate

 

A26
Trans-4-((4-((2-(1- (phenylsulfonyl))indolin-5- yl)cyclopropylamino)methyl) piperidin-1-yl)methyl)benzoic acid

 

A27
Trans-tert-butyl 4-((2-(1- (phenylsulfonyl)indolin-5- yl)cyclopropylamino)methyl) piperidine-1-carboxylate

 

A28
Trans-benzyl 4-((2-(1- (phenylsulfonyl)indolin-5- yl)cyclopropylamino)methyl) piperidine-1-carboxylate

 

A29
Trans-tert-butyl 4-(2-(1- (phenylsulfonyl)indolin-5- yl)cyclopropylcarbamoyl)piperidine-1- carboxylate

 

A30
Trans-2-(1-(phenylsulfonyl)indolin-5- yl)-N-(1-(piperidin-4- yl)ethyl)cyclopropylamine

 

A31
Trans-2-(1-(phenylsulfonyl)indolin-5- yl)-N-(2-(piperidin-4-yl)propan-2- yl)cyclopropylamine

 

A32
Trans-2-(1-(biphenyl-4- ylsulfonyl)indolin-5-yl)-N-(piperidin-4- ylmethyl)cyclopropylamine

 

A33
Trans-2-(1-(naphthalen-2- ylsulfonyl)indolin-5-yl)-N-(piperidin-4- ylmethyl)cyclopropylamine

 

A34
trans-N-(piperidin-4-ylmethyl)-2-(1-(4- (trifluoromethyl)benzenesulfonyl) indolin-5-yl)cyclopropylamine

 

A35
trans-N-(piperidin-4-ylmethyl)-2-(1-(3- (trifluoromethyl)benzenesulfonyl) indolin-5-yl)cyclopropylamine

 

A36
trans-N-(piperidin-4ylmethyl)-2-(1-(2- (trifluoromethyl)benzenesulfonyl) indolin-5-yl)cyclopropylamine

 

A37
trans-N-(piperidin-4-ylmethyl)-2-(1-(m- toluenesulfonyl)indolin-5- yl)cyclopropylamine

 

A38
trans-2-(1-(3- chlorobenzenesulfonyl)indolin-5-yl)-N- (piperidin-4- ylmethyl)cyclopropylamine

 

A39
trans-2-(1-(3- methoxybenzenesulfonyl)indolin-5-yl)- N-(piperidin-4- ylmethyl)cyclopropylamine

 

A40
Trans-2-(1-(methylsulfonyl)indolin-5- yl)-N-(piperidin-4- ylmethyl)cyclopropylamine

 

A41
trans-N-(piperidin-4-ylmethyl)-2-(1- (propylsulfonyl)indolin-5- yl)cyclopropylamine

 

A42
trans-N-(piperidin-4-ylmethyl)-2-(1- (trifluoromethanesulfonyl)indolin-5- yl)cyclopropylamine

 

A43
trans-2-(1-(cyclohexylsulfonyl)indolin- 5-yl)-N-(piperidin-4- ylmethyl)cyclopropylamine

 

A44
trans-2-(1-(tert-butylsulfonyl)indolin-5- yl)-N-(piperidin-4- ylmethyl)cyclopropylamine

 

A45
trans-phenyl (5-(2-(piperidin-4- ylmethylamino)cyclopropyl)indolin-1- yl)methanone

 

A46
Trans-naphthalen-2-yl(5-(2-(piperidin- 4-ylmethylamino)cyclopropyl)indolin- 1-yl)methanone

 

A47
Trans-biphenyl-4-yl(5-(2-(piperidin-4- ylmethylamino)cyclopropyl)indolin-1- yl)methanone

 

A48
Trans-(5-(2-(piperidin-4- ylmethylamino)cyclopropyl)indolin-1- yl)(3- (trifluoromethyl)phenyl)methanone

 

A49
Trans-2-phenyl-1-(5-(2-(piperidin-4- ylmethylamino)cyclopropyl)indolin-1- yl)ethanone

 

A50
Trans-benzyl-5-(2-(piperidin-4- ylmethylamino)cyclopropyl)indoline-1- carboxylate

 

A51
Trans-1-(5-(2-(piperidin-4- ylmethylamino)cyclopropyl)indolin-1- yl)ethanone

 

A52
Trans-2,2,2-trifluoro-1-(5-(2-(piperidin- 4-ylmethylamino)cyclopropyl)indolin- 1-yl)ethanone

 

A53
Trans-1-(5-(2-(piperidin-4- ylmethylamino)cyclopropyl)indolin-1- yl)propan-1-one

 

A54
Trans-1-(5-(2-(piperidin-4- ylmethylamino)cyclopropyl)indolin-1- yl)butan-1-one

 

A55
Trans-1-(5-(2-(piperidin-4- ylmethylamino)cyclopropyl)indolin-1- yl)pentan-1-one

 

A56
Trans-3-methoxy-1-(5-(2-(piperidin-4- ylmethylamino)cyclopropyl)indolin-1- yl)propan-1-one

 

A57
Trans-2-methyl-1-(5-(2-(piperidin-4- ylmethylamino)cyclopropyl)indolin-1- yl)propan-1-one

 

A58
Trans-2,2-dimethyl-1-(5-(2-(piperidin- 4-ylmethylamino)cyclopropyl)indolin- 1-yl)propan-1-one

 

A59
Trans-cyclohexyl (5-(2-(piperidin-4- ylmethylamino)cyclopropyl)indolin-1- yl)methanone

 

A60
Trans-cycloheptyl (5-(2-(piperidin-4- ylmethylamino)cyclopropyl)indolin-1- yl)methanone

 

A61
Trans-cyclopentyl (5-(2-(piperidin-4- ylmethylamino)cyclopropyl)indolin-1- yl)methanone

 

A62
Trans-cyclobutyl (5-(2-(piperidin-4- ylmethylamino)cyclopropyl)indolin-1- yl)methanone

 

A63
Trans-cyclopropyl (5-(2-(piperidin-4- ylmethylamino)cyclopropyl)indolin-1- yl)methanone

 

A64
trans-N-(2-(1-(phenylsulfonyl)-1,2,3,4- tetrahydroquinolin-6- yl)cyclopropyl)aniline

 

A65
trans-N-benzyl-2-(1-(phenylsulfonyl)- 1,2,3,4-tetrahydroquinolin-6- yl)cyclopropylamine

 

A66
trans-N-(2-(1-(phenylsulfonyl)-1,2,3,4- tetrahydroquinolin-6- yl)cyclopropyl)piperidin-4-amine

 

A67
Trans-2-(1-(phenylsulfonyl)-1,2,3,4- tetrahydroquinolin-6-yl)-N-(piperidin- 4-ylmethyl)cyclopropylamine

 

A68
trans-N-(piperidin-4-ylmethyl)-2-(1- (propylsulfonyl)-1,2,3,4- tetrahydroquinolin-6- yl)cyclopropylamine

 

A69
trans-2-(1-(cyclohexylsulfonyl)-1,2,3,4- tetrahydroquinolin-6-yl)-N-(piperidin- 4-ylmethyl)cyclopropylamine

 

A70
trans-phenyl(6-(2-(piperidin-4- ylmethylamino)cyclopropyl)-3,4- dihydroquinolin-1(2H)-yl)methanone

 

A71
trans-1-(6-(2-(piperidin-4- ylmethylamino)cyclopropyl)-3,4- dihydroquinolin-1(2H)-yl)butan-1-one

 

A72
trans-cyclohexyl (6-(2-(piperidin-4- ylmethylamino)cyclopropyl)-3,4- dihydroquinolin-1(2H)-yl)methanone