Patent ID: 11958861
Assignee: INCYTE CORPORATION
Field: Organic fine chemistry (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 49:
50. The compound of claim 1, which is selected from:
6-methyl-2-(4-((4-(methylsulfonyl)piperidin-1-yl)methyl)phenyl)-1-phenyl-2′,3,3′,5′,6,6′-hexahydro-7H-spiro[dipyrrolo[2,3-b:3′,2′-d]pyridine-8,4′-pyran]-7-one;
6-methyl-2-(4-((4-(methylsulfonyl)piperidin-1-yl)methyl)phenyl)-1-phenyl-3,4′,5′,6-tetrahydro-2′H,7H-spiro[dipyrrolo[2,3-b:3′,2′-d]pyridine-8,3′-furan]-7-one;
1-(1-acetylpiperidin-4-yl)-6′-methyl-2′-(4-((4-(methylsulfonyl)piperidin-1-yl)methyl)phenyl)-1′-phenyl-3′,6′-dihydro-7′H-spiro[azetidine-3,8′-dipyrrolo[2,3-b:3′,2′-d]pyridin]-7′-one;
3-(6-methyl-2-(4-((4-(methylsulfonyl)piperidin-1-yl)methyl)phenyl)-7-oxo-1-phenyl-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3′,2′-d]pyridine-8,4′-piperidin]-1′-yl)propanenitrile;
3-(6-methyl-1-(1-methyl-1H-indazol-5-yl)-2-(4-((4-(methylsulfonyl)piperidin-1-yl)methyl)phenyl)-7-oxo-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3′,2′-d]pyridine-8,4′-piperidin]-1′-yl)propanenitrile;
2-(4-(4-(6-methyl-2-(1-methyl-1H-pyrazol-4-yl)-7-oxo-1-phenyl-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3′,2′-d]pyridine-8,4′-piperidin]-1′-yl)-1H-pyrazol-1-yl)tetrahydro-2H-pyran-4-yl)acetonitrile;
3-(6-methyl-1-(1-methyl-1H-indazol-5-yl)-2-(1-(methyl-d3)-1H-pyrazol-4-yl)-7-oxo-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3′,2′-d]pyridine-8,4′-piperidin]-1′-yl)propanenitrile;
6′-methyl-1′-(1-methyl-1H-indazol-5-yl)-2′-(1-(pyridin-4-ylmethyl)-1H-pyrazol-4-yl)-3′,6′-dihydro-7′H-spiro[cyclopentane-1,8′-dipyrrolo[2,3-b:3′,2′-d]pyridin]-7′-one;
2′-cyclopropyl-6′-methyl-1′-(1-methyl-1H-indazol-5-yl)-3′,6′-dihydro-7′H-spiro[cyclopentane-1,8′-dipyrrolo[2,3-b:3′,2′-d]pyridin]-7′-one;
6′-methyl-2′-(4-((4-(methylsulfonyl)piperidin-1-yl)methyl)phenyl)-1′-phenyl-3′,6′-dihydro-7′H-spiro[cyclobutane-1,8′-dipyrrolo[2,3-b:3′,2′-d]pyridin]-7′-one;
6′-methyl-2′-(4-((4-(methylsulfonyl)piperidin-1-yl)methyl)phenyl)-1′-phenyl-3′,6′-dihydro-7′H-spiro[cyclohexane-1,8′-dipyrrolo[2,3-b:3′,2′-d]pyridin]-7′-one;
6-methyl-2-(4-((4-(methylsulfonyl)piperidin-1-yl)methyl)phenyl)-1-phenyl-1′-(2-(tetrahydro-2H-pyran-4-yl)acetyl)-3,6-dihydro-7H-spiro[dipyrrolo[2,3-b:3′,2′-d]pyridine-8,3′-pyrrolidin]-7-one;
8-acetyl-6′-methyl-2′-(4-((4-(methylsulfonyl)piperidin-1-yl)methyl)phenyl)-1′-phenyl-3′,6′-dihydro-7′H-8-azaspiro[bicyclo[3.2.1]octane-3,8′-dipyrrolo[2,3-b:3′,2′-d]pyridin]-7′-one; and
3-(4-(4-(6′-methyl-2′-(1-methyl-1H-pyrazol-4-yl)-7′-oxo-6′,7′-dihydro-3′H-spiro[cyclopentane-1,8′-dipyrrolo[2,3-b:3′,2′-d]pyridin]-1′-yl)phenyl)-1H-pyrazol-1-yl)butanenitrile;
or a pharmaceutically acceptable salt thereof.