Patent ID: 11918589
Assignee: NIPPON CHEMIPHAR CO., LTD
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 3:
4. A method of therapeutic treatment of multiple sclerosis, the method comprising administering a medicament which contains a compound having P2X4 receptor antagonist activity, or a shift thereof, or a hydrate or solvate thereof as an active ingredient, wherein the compound is a compound represented by the following the general formula (IG):, , wherein, in the formula, R1G, R2G, and R3G may be the same or different, and represent hydrogen atom, an alkyl group having 1 to 8 carbon atoms, a cycloalkyl group having 3 to 8 carbon atoms, an alkenyl group having 2 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms and substituted with 1 to 3 halogen atoms, an alkoxy group having 1 to 8 carbon atoms and substituted with 1 to 3 halogen atoms, a halogen atom, hydroxyl group, nitro group, cyano group, amino group, an alkylamino group having 1 to 8 carbon atoms, or a dialkylamino group having 2 to 8 carbon atoms,
XG represents C or N,
YG represents N or C(═O),
provided that when XG is C, YG represents N, and
when XG is N, YG represents C(═O),
the double line consisting of the solid line and the broken line represents a single bond or a double bond,
nG represents an integer of 0 to 6,
ZG represents O, S, or an atomic bond, and
AG represents benzene ring, pyridine ring, piperazine ring, piperidine ring, or morpholine ring which can have 1 to 5 of the same or different substituents selected from an alkyl group having 1 to 8 carbon atoms, a cycloalkyl group having 3 to 8 carbon atoms, an alkenyl group having 2 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms and substituted with 1 to 3 halogen atoms, an alkoxy group having 1 to 8 carbon atoms and substituted with 1 to 3 halogen atoms, a halogen atom, hydroxyl group, nitro group, cyano group, amino group, an alkylamino group having 1 to 8 carbon atoms, and N(R4G)(R5G), wherein R4G and R5G represent the same or different alkyl groups having 1 to 8 carbon atoms, or R4G, R5G and the nitrogen atom to which R4G and R5G bind together to represent a 5- to 7-membered ring which may further contain oxygen atom or sulfur atom as a ring-forming heteroatom.