Patent ID: 11939336
Assignee: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION
Field: Chemical engineering (Chemistry)
Classification: CPC C  B | IPC B  C

Claim 26:
27. A method of synthesizing an aryl-triazole bicyclic macrocycle of Formula (VII):, wherein n=1 to 4, and R1 and R2 are independently selected from the group consisting of alkenyl, alkyl, alkoxy, alkyl-NH-alkyl, aryl, cycloalkyl, heteroaryl, heterocycle, haloalkyl, hydrogen, iodo, —OR3, —N(R4R5), —CO2R6, —C(O)—N(R7R8), wherein R3, R4, R5, R6, R7, and R8 are each independently selected from the group consisting of alkenyl, alkyl, aryl, arylalkyl, cycloalkyl, heteroaryl, heterocycle, haloalkyl, and hydrogen,
the method comprises:
preparing macrocycle intermediate MC1-1:, (MC1-1); and
alkylating macrocycle intermediate MC1-1 to produce the aryl-triazole bicyclic macrocycle of Formula (VII).