Patent ID: 11932691
Assignee: FRED HUTCHINSON CANCER CENTER
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A  G | IPC C  G

Claim 0:
1. A method of detecting a receptor tyrosine kinase-like orphan receptor 1 (ROR1) protein in a biological sample, the method comprising:
(a) contacting a biological sample with a binding protein, wherein the biological sample is from a human subject and wherein the binding protein comprises an antibody or a binding fragment thereof comprising:
(1) a heavy chain comprising CDR sequences set forth as SEQ ID NOs.:21, 25, and 29 and a light chain comprising CDR sequences set forth as SEQ ID NOs.:31, 33 and 35;
(2) a heavy chain comprising CDR sequences set forth as SEQ ID NOs.:22, 26, and 29 and a light chain comprising CDR sequences set forth as SEQ ID NOs.:31, 33, and 35;
(3) a heavy chain comprising CDR sequences set forth as SEQ ID NOs.:23, 27, and 29 and a light chain comprising CDR sequences as set forth as SEQ ID NOs.:31, 33, and 35; or
(4) a heavy chain comprising CDR sequences set forth as SEQ ID NOs.:24, 28, and 30 and a light chain comprising CDR sequences set forth as SEQ ID NOs.:32, 34, and 36; and

(b) detecting the specific binding between the binding protein and the ROR1 protein in the biological sample, or lack thereof, wherein the method detects the presence or absence of the ROR1 protein in the biological sample.