Patent ID: 11866481
Assignee: NATIONAL RESEARCH COUNCIL OF CANADA
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A polypeptide useful to inhibit an effect of a Transforming Growth Factor Beta (TGF-β) isotype, the polypeptide comprising from N-terminus to C-terminus:
a first region comprising a first TGF-β receptor ectodomain (TβR-ECD) linked to a second TβR-ECD, wherein the C-terminus of the first TβR-ECD is linked to the N-terminus of the second TβR-ECD by a first linker; and
a second region comprising the second constant domain (CH2) and/or third constant domain (CH3) of an antibody heavy chain, wherein the second region comprises an amino acid sequence selected from the group consisting of SEQ ID NO:12, SEQ ID NO:15, SEQ ID NO:18, and SEQ ID NO:24;
wherein the N-terminus of the second region is linked to the C-terminus of the first region by a second linker having the amino acid sequence of SEQ ID NO: 8.