Patent ID: 11946033
Assignee: REPLIGEN CORPORATION
Field: Chemical engineering (Chemistry)
Classification: CPC C  B | IPC B  C

Claim 0:
1. A micro alternating tangential flow perfusion device (microATF device) having dimensions suitable for an exchange volume of from 0.5-5 ml comprising
a hollow cylinder having a proximal end and a distal end, said proximal end being connected in series to a permeate chamber, followed by a retentate chamber, wherein the proximal end either (i) terminates in or at the permeate chamber, or (ii) terminates in or at the retentate chamber, wherein a portion of the proximal end is located within the permeate chamber, and in a case of (ii), possesses at least one opening allowing fluid communication between an inside of the hollow cylinder and the permeate chamber;
an inlet, positioned over the retentate chamber, for communication with a source of positive or negative pressure;
an outlet, positioned in a wall of the permeate chamber, which can be connected to a check valve, which, in turn, can be connected to a hydrophobic fluid vent filter.