Patent ID: 11964012
Assignee: CUREVAC SE
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A

Claim 0:
1. A purified mRNA comprising, from 5′ to 3′:
(a) a 5′ cap;
(b) a 5′ untranslated region (UTR);
(c) a coding sequence encoding a SARS-CoV-2 spike protein at least 95% identical to the amino acid sequence of SEQ ID NO: 10 that is a pre-fusion stabilized spike protein comprising K986P and V987P stabilizing substitutions relative to SEQ ID NO: 10, wherein the coding sequence is at least 95% identical to the RNA sequence of SEQ ID NO: 146;
(d) a 3′ UTR; and
(e) at least one poly(A) sequence comprising 30 to 200 adenosine nucleotides,
wherein the mRNA optionally comprises a 1-methylpseudouridine or a pseudouridine substitution nucleotide substitution at one or more uracil position(s).