Patent ID: 11883378
Assignee: PYKUS THERAPEUTICS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A

Claim 0:
1. An injectable, ocular formulation for forming a hydrogel in an eye of a subject, the formulation comprising:
a. a nucleo-functional polymer that is a biocompatible polymer comprising poly(vinyl alcohol) containing a plurality of thio-functional groups —R1—SH , wherein —R1—SH is —OC(O)—(C1-C6 alkylene)—SH;
b. an electro-functional polymer that is a biocompatible polymer comprising poly(ethylene glycol) containing at least one thiol-reactive group; and
c. a liquid pharmaceutically acceptable carrier comprising 5×phosphate buffered saline (PBS) that is suitable for administration of the ocular formulation to the eye of the subject;
wherein the ocular formulation has a pH in the range of about 7.1 to about 7.7, an osmolality in the range of about 280 mOsm/kg to about 320 mOsm/kg and the formulation forms a hydrogel in the eye of the subject.