Patent ID: 11912989
Assignee: CHUGAI SEIYAKU KABUSHIKI KAISHA
Field: Biotechnology (Chemistry)
Classification: CPC C  A | IPC C

Claim 10:
11. A method of screening a library for an antigen-binding molecule comprising an antigen-binding domain whose binding to an antigen varies depending on the concentration of a small molecule compound that is not the antigen, the method comprising:
(a) providing the library of claim 1, wherein the library comprises the plurality of antigen-binding domains of (i);
(b) contacting the plurality of antigen-binding domains with the first antigen in the presence of a first concentration of the small molecule compound; and
(c) identifying an antigen-binding domain of the plurality that binds to the first antigen in the presence of the small molecule compound at the first concentration but not in the presence of the small molecule compound at a second concentration that is lower than the first concentration.