Patent ID: 11970517
Assignee: REJUKON BIOPHARM INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 4:
5. A polynucleotide encoding a polypeptide comprising a hydrophilic segment and a hydrophobic segment, wherein the hydrophilic segment comprises a sequence selected from the group consisting of:
TEPQEESEEEVEEPEER (SEQ ID NO: 15),
TDPQDDSDDDVDDPDDR (SEQ ID NO: 16),
TKPQKKSKKKVKKPKKR (SEQ ID NO: 17),
TRPQRRSRRRVRRPRRR (SEQ ID NO: 18),
ELDEESEDEVEEEQEDR (SEQ ID NO: 19),
KEEVDEDRDVDE (SEQ ID NO: 20), and
EKSEQDLE (SEQ ID NO: 21), or a sequence having at least 90% identity thereto,
wherein the hydrophobic segment comprises a sequence selected from the group consisting of:
TFYDQTVSNDL (SEQ ID NO: 22),
ANSAYYDAHPVTNGI (SEQ ID NO: 23),
PPQTAAREATSIPGFPAEGAIPLPV (SEQ ID NO: 24), and
EGEVAEEPNSRP (SEQ ID NO: 25), or a sequence having at least 90% identity thereto,
wherein the hydrophilic segment is at the N-terminus and the hydrophobic segment is at the C-terminus,
wherein the polypeptide has a length of 20-60 amino acid residues, and
wherein the polypeptide is capable of dissolving a protein aggregate.