Patent ID: 11873484
Assignee: MICROSOFT TECHNOLOGY LICENSING, LLC
Field: Biotechnology (Chemistry)
Classification: CPC C  B  G | IPC B  C  G

Claim 0:
1. A method of selectively assembling an oligonucleotide on a microelectrode array coated with a plurality of anchor sequences, the method comprising:
introducing a first oligonucleotide complex encoding a first arbitrary value into a reaction chamber containing the microelectrode array;
activating a first subset of electrodes in the microelectrode array to attract the first oligonucleotide complex to the first subset of electrodes having attached thereto a first subset of anchor sequences;
introducing a second oligonucleotide complex encoding a second arbitrary value into the reaction chamber;
activating a second subset of electrodes in the microelectrode array to attract the second oligonucleotide complex to the second subset of electrodes having attached thereto a second subset of anchor sequences; and
closing nicks in assembled double-stranded oligonucleotides attached to the microelectrode array, the assembled double-stranded oligonucleotides formed at least in part by hybridization of the first oligonucleotide complex to the first subset of anchor sequences or by hybridization of the second oligonucleotide complex to the second subset of anchor sequences.