Patent ID: 11905327
Assignee: NANJING LEGEND BIOTECH CO., LTD.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A  Y | IPC A  C

Claim 14:
15. The anti-TIGIT construct of claim 10, wherein the full-length antibody specifically recognizes PD-L1, and:
(a) wherein the full-length antibody comprises a heavy chain comprising the amino acid sequence of SEQ ID NO: 329, and a light chain comprising the amino acid sequence of SEQ ID NO: 330, wherein at least one of the heavy chains of the full-length antibody is fused to the sdAb moiety specifically recognizing TIGIT, and wherein the heavy chain fusion polypeptide comprises the amino acid sequence of SEQ ID NO: 402 or 341;
(b) wherein the full-length antibody comprises a heavy chain comprising the amino acid sequence of SEQ ID NO: 323, and a light chain comprising the amino acid sequence of SEQ ID NO: 328, wherein at least one of the heavy chains of the full-length antibody is fused to the sdAb moiety specifically recognizing TIGIT, and wherein the heavy chain fusion polypeptide comprises the amino acid sequence of SEQ ID NO: 357 or 359;
(c) wherein the full-length antibody comprises a heavy chain comprising the amino acid sequence of SEQ ID NO: 390, and a light chain comprising the amino acid sequence of SEQ ID NO: 391, wherein at least one of the heavy chains of the full-length antibody is fused to the sdAb moiety specifically recognizing TIGIT, and wherein the heavy chain fusion polypeptide comprises the amino acid sequence of SEQ ID NO: 394 or 396;
(d) wherein the full-length antibody comprises a heavy chain comprising the amino acid sequence of SEQ ID NO: 390, and a light chain comprising the amino acid sequence of SEQ ID NO: 391, wherein at least one of the light chains of the full-length antibody is fused to the sdAb moiety specifically recognizing TIGIT, and wherein the light chain fusion polypeptide comprises the amino acid sequence of SEQ ID NO: 399 or 401;
(e) wherein the full-length antibody comprises a heavy chain comprising the amino acid sequence of SEQ ID NO: 329, and a light chain comprising the amino acid sequence of SEQ ID NO: 330, wherein at least one of the light chains of the full-length antibody is fused to the sdAb moiety specifically recognizing TIGIT, and wherein the light chain fusion polypeptide comprises the amino acid sequence of SEQ ID NO: 405;
(f) wherein the full-length antibody comprises a heavy chain comprising the amino acid sequence of SEQ ID NO: 327, and a light chain comprising the amino acid sequence of SEQ ID NO: 328, wherein at least one of the heavy chains of the full-length antibody is fused to the sdAb moiety specifically recognizing TIGIT, and wherein the heavy chain fusion polypeptide comprises the amino acid sequence of SEQ ID NO: 343;
(g) wherein the full-length antibody comprises a heavy chain comprising the amino acid sequence of SEQ ID NO: 333, and a light chain comprising the amino acid sequence of SEQ ID NO: 334, wherein at least one of the heavy chains of the full-length antibody is fused to the sdAb moiety specifically recognizing TIGIT, and wherein the heavy chain fusion polypeptide comprises the amino acid sequence of SEQ ID NO: 345;
(h) wherein the full-length antibody comprises a heavy chain comprising the amino acid sequence of SEQ ID NO: 331, and a light chain comprising the amino acid sequence of SEQ ID NO: 332, wherein at least one of the heavy chains of the full-length antibody is fused to the sdAb moiety specifically recognizing TIGIT, and wherein the heavy chain fusion polypeptide comprises the amino acid sequence of SEQ ID NO: 347; or
(i) wherein the full-length antibody comprises a heavy chain comprising the amino acid sequence of SEQ ID NO: 323, and a light chain comprising the amino acid sequence of SEQ ID NO: 328, wherein at least one of the light chains of the full-length antibody is fused to the sdAb moiety specifically recognizing TIGIT, and wherein the light chain fusion polypeptide comprises the amino acid sequence of SEQ ID NO: 362 or 364.