Patent ID: 11944688
Assignee: SUTURA THERAPEUTICS LTD
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 10:
11. The method of claim 1, wherein the BFL comprises:, , a residue of succinimidyl 4-(N-maleimidomethyl) cyclohexane-1-carboxylate, where Z is, , and Y is a covalent bond to the N-terminus of the StaP or the StiP, or Y is, , where n is 1 to 10;, , a residue of N-α-maleimidoacet-oxysuccinimide ester, where Z is, , and Y is a covalent bond to the N-terminus of the StaP or the StiP, or Y is, , where n is 1 to 10;, , a residue of N-β-maleimidopropyl-oxysuccinimide ester, where Z is, , and Y is a covalent bond to the N-terminus of the StaP or the StiP, or Y is, , where n is 1 to 10;, , a residue of N-γ-aleimidobutyryl-oxysuccinimide ester, where Z is, , and Y is a covalent bond to the N-terminus of the StaP or the StiP, or Y is, , where n is 1 to 10;, , a residue of N-δ-maleimidovaleryl-oxysuccinimide ester, where Z is, , and Y is a covalent bond to the N-terminus of the StaP or the StiP, or Y is, , where n is 1 to 10;, , a residue of N-ε-malemidocaproyl-oxysuccinimide ester, where Z is, , and Y is a covalent bond to the N-terminus of the StaP or the StiP, or Y is, , where n is 1 to 10, , a residue of succinimidyl 4-(N-maleimidomethyl) cyclohexane-1-carboxy-(6-amidocaproate),, where Z is, , and Y is a covalent bond to the N-terminus of the StaP or the StiP, or Y is, , where n is 1 to 10;, , a residue of succinimidyl 4-(N-maleimidomethyl) cyclohexane-1-carboxylate (polyethylene glycol)n, wherein n equals 1 to 10, Z is, , and, Y is either present or not present, and when Y is present, Y is, , where n is 1 to 10, and when Y is not present, Y is a covalent bond to the N-terminus of the StaP or the StiP;, , a residue of disuccinimidyl gluterate, where Z is not present, and instead there is a covalent bond to the N-terminus of the StaP or the StiP, or to the N of, , wherein n is 1 to 10;, or,, , a residue of disuccinimidyl-cyclohexl-1,4-diester, where Z is not present, and instead there is a covalent bond to the N-terminus of the StaP or the StiP, or to the N of, , wherein n is 1 to 10.