Patent ID: 11865160
Assignee: THE SCRIPPS RESEARCH INSTITUTE
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 0:
1. A composition comprising a peptide, a staple, and a half-life extending molecule comprising i) a lipid, ii) a polyglycol unit, or iii) a lipid and a polyglycol unit; wherein the peptide comprises a glucagon-like protein-1 receptor (GLP1R) agonist, a glucagon receptor (GCGR) agonist, a glucagon-like protein-2 receptor (GLP2) agonist, a glucose-dependent insulinotropic peptide receptor (GIPR) agonist, a GLP1R and GIPR dual agonist, a GLP1R and GCGR dual agonist, or a GLP1R, GCGR and GIPR tri-agonist; wherein a first amino acid and a second amino acid of the GLP1R agonist, the GCGR agonist, the GLP2 agonist, the GIPR agonist, the GLP1R and GIPR dual agonist, the GLP1R and GCGR dual agonist, or the GLPR1R, GCGR and GIPR tri-agonist, are connected via covalent attachment to the staple; and wherein the half-life extending molecule is covalently attached to the staple.