Patent ID: 11912654
Assignee: SYNERGIA LIFE SCIENCES PVT. LTD.
Field: Organic fine chemistry (Chemistry)
Classification: CPC C | IPC C

Claim 0:
1. A process for the synthesis of Vitamin K2 of Formula I,, , wherein n is 3 or 4, and the process comprises:
(a) adding menadione/cyclopentadiene adduct to t-butanol:toluene mixture that is in the range of 10:90 to 20:80 v/v, at a temperature ranging from 20° C. to 40° C.;
(b) dissolving potassium t-butoxide in reaction mixture of (a);
(c) adding prenyl chloride to the reaction mixture of (b) and stirring the mixture for an hour;
(d) quenching the reaction mixture of (c) in distilled water;
(e) adjusting the pH of the reaction mixture of (d) to 5-6 and isolating the non-aqueous layer;
(f) washing the non-aqueous layer of (e) with water and brine, and drying the washed non-aqueous layer over sodium sulfate;
(g) recovering the product Vitamin K2-3 from the non-aqueous layer of (f) by reflux and distilling off the solvent under vacuum, wherein Vitamin K2-3 has the chemical structure:, (h) converting the Vitamin K2-3 obtained in (g) into its dibenzyl ether having the chemical structure:, , wherein Ph is a phenyl group;
(i) converting the dibenzyl ether of Vitamin K2-3 obtained in (h) into its bromohydrin derivative in the presence of N-bromo succinamide and tetrahydrofuran, wherein the bromohydrin derivative of dibenzyl ether of vitamin K2-3 has the chemical structure:, (j) converting the bromohydrin derivative of dibenzyl ether of vitamin K2-3 obtain in (i) to its epoxide in the presence of potassium carbonate and methanol, wherein the epoxide derivative of dibenzyl ether of vitamin K2-3 has the chemical structure:, (k) converting the epoxide derivative of dibenzyl ether of vitamin K2-3 obtained in (j) into Vitamin K2-3 alcohol in the presence of aluminium isopropoxide in toluene, wherein the Vitamin K2-3 alcohol has the chemical structure:, (l) reacting the Vitamin K2-3 alcohol obtained in (k) with thionyl chloride in hexane to form Vitamin K2-3 chloride having the chemical structure:, (m) reacting the Vitamin K2-3 chloride obtained in (l) with a prenyl phenyl sulphonate to obtain a compound, wherein the prenyl phenyl sulphonate is selected from:, (n) desulphonating, deprotecting, and oxidizing the compound obtained in (m) to obtain Vitamin K2 of Formula I.