Patent ID: 11918352
Assignee: ISBRG CORP.
Field: Medical technology (Instruments)
Classification: CPC A | IPC A

Claim 17:
18. A device for detecting a physiological state of interest of a subject, comprising:
a source of electromagnetic radiation (EMR) that emits a plurality of wavelengths of EMR from about 400 nm to about 2500 nm, the source of EMR being operatively coupled to a power source;
a receptor sized to register with, and fit against, a sample, the receptor comprising at least one port;
at least one input radiation guiding element in operable association with the source of EMR, at least one output radiation guiding element in operable association with a detector,
the at least one input radiation guiding element and the at least one output radiation guiding element in optical alignment with the at least one port located and defining an EMR path within the receptor when the receptor is registered with, and fit against, the sample;
the detector for measuring transmitted or reflected EMR received from the sample to obtain a spectrum, the detector operatively coupled to a processing system;
the processing system configured to use at least one algorithm for determining a concentration for at least one known analytes in the sample,
wherein the processing system is configured to use the at least one algorithm to derive a biochemical profile from the concentration of the at least one known analyte and from the spectrum corresponding to multiple ghost analytes whose identities are unknown and that are observed to change in response to the physiological state of interest, and to analyze the biochemical profile to determine the physiological state of interest of the subject from the sample, wherein, the physiological state of interest is:
i) cannabis induced intoxication, and the at least one known analyte is selected from the group consisting of: delta-9-tetrahydrocannabinol (THC), THC glucuronide (THCGlu), 11-nor-9-carboxy-THC (THC-COOH), 11-hydroxy THC (11-OH-THC), THC-COOH/11-OH-THC ratio, 11-nor-9-carboxy-THC glucuronide (THC-COOGlu), cannabidol (CBD), cannbinol (CBN), cannabigerol (CBG), delta-9-tetrahydrocannabivarin (THCV), THCV-carboxylic acid, 11-nor-9-carboxy-delta—tetrahydrocannabivarin (THCV-COOH), albumin, apolipoproteins A1 and B (apoA1 and apoB), total protein, bilirubin, prolactin, triglycerides, creatinine, cortisol, glucose, lactate, Total 4, uric acid, blood urea nitrogen (BUN), blood sugar, calcium, ionized calcium, magnesium, sodium, phosphate, and GABA;
ii) alcohol induced intoxication, and the at least one known analyte is selected from the group consisting of: alcohol, aldehyde, lactic acid; or
iii) intoxication arising from cannabis, alcohol, opiates, fentanyl, amphetamines, phencyclidine, sedatives, anxyolytics, cocaine, caffeine, and nicotine consumption, and the at least one known analyte is selected from the group consisting of: delta-9-tetrahydrocannabinol (THC), THC glucuronide (THCGlu), 11-nor-9-carboxy-THC (THC-COOH), 11-hydroxy THC (11-OH-THC), THC-COOH/11-OH-THC ratio, 11-nor-9-carboxy-THC glucuronide (THC-COOGlu), cannabidol (CBD), cannbinol (CBN), cannabigerol (CBG), delta-9-tetrahydrocannabivarin (THCV), THCV-carboxylic acid, 11-nor-9-carboxy-delta—tetrahydrocannabivarin (THCV-COOH), albumin, apolipoproteins A1 and B (apoA1 and apoB), total protein, bilirubin, prolactin, triglycerides, creatinine, cortisol, glucose, lactate, Total 4, uric acid, blood urea nitrogen (BUN), blood sugar, calcium, ionized calcium, magnesium, sodium, phosphate, GABA, alcohol, aldehyde, and lactic acid.