Patent ID: 11940427
Assignee: ROCHE DIAGNOSTICS OPERATIONS, INC.
Field: Measurement (Instruments)
Classification: CPC G | IPC G

Claim 16:
17. A method for chemical analysis in a liquid chromatography-mass spectrometry (LC-MS) apparatus, the method comprising:
alternately connecting multiple fluidic streams from a liquid chromatography (LC) system to an ionization source coupled to the LC system, thereby assigning a detection time window to each fluidic stream from the multiple fluidic streams when connected to the ionization source;
monitoring an ionization current of the ionization source for the multiple fluidic streams;
identifying differences in flow conditions between the multiple fluidic streams based on the monitored ionization current;
adjusting detection conditions of one or more of the multiple fluidic streams responsive to the identified differences, thereby enabling eluates of interest from each fluidic stream to be detected by a mass spectrometer coupled to the ionization source in the respective detection time window.