Patent ID: 11931330
Assignee: KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 0:
1. A method for inhibiting muscle aging, comprising:
administering a composition comprising an effective amount of an azelaic acid or a pharmaceutically acceptable salt thereof as an active ingredient to a muscle cell of a subject orally, or by intrarectal, intravenous, intramuscular, subcutaneous, intrauterine dura mater or intracerebroventricular injection,
wherein the inhibition of muscle aging is accomplished by promoting mitochondrial biogenesis in the muscle cell,
wherein the method increases an expression of a peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α) in the muscle cell,
wherein the azelaic acid or the pharmaceutically acceptable salt thereof functions as a ligand of Olfr544 in muscle cells, and
wherein the azelaic acid is administered at a concentration of 50 μM.