Patent ID: 11944690
Assignee: BAYER AKTIENGESELLSCHAFT
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 11:
12. The process according to claim 11, further comprising:
dissolving an amount of the Ca-BT-DO3A (Calcobutrol) in the range of 0.002% to 5% mol/mol (inclusive) with reference to the total concentration of the Gd3+ in the formulation in the pharmaceutically acceptable solvent to form a first solution; and
dissolving the DO3A-derived tetra-chelate of formula (I) in the first solution in sufficient amount to produce a final solution having a liquid pharmaceutical formulation having a concentration of the DO3A-derived tetra-chelate of formula (I) in a range of 1 mmol paramagnetic metal ion/L to 1000 mmol Gd3+/L (inclusive).