Patent ID: 11896715
Assignee: KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 12:
13. A method for preparing an in-vivo bulking agent formulated as an injectable composition, the method comprising:
mixing polydimethylsiloxane particles and a zwitterionic polymer to prepare a first composition in which the zwitterionic polymer is surrounded on a surface of the polydimethylsiloxane particles; and
dispersing the first composition in a second composition having a viscosity of 100 to 1500 cps at room temperature;, wherein the first composition includes 0.1 to 5 parts by weight of the zwitterionic polymer based on 100 parts by weight of the polydimethylsiloxane particles and the zwitterionic polymer is a random copolymer including a first monomer having a zwitterion ion and a second monomer containing an acrylic acid ester, wherein the first monomer is one or more selected from the group consisting of methacryloyloxyethyl phosphorylcholine (MPC), carboxybetaine methacrylate (CBMA), and sulfobetaine methacrylate (SBMA).