Patent ID: 11952557
Assignee: NOVOZYMES A/S
Field: Biotechnology (Chemistry)
Classification: CPC C | IPC C

Claim 17:
18. The variant of claim 1, which has an IF of at least >1.5 when compared to the parent alpha-amylase, and which comprises:, N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + K391A + G476K,

N54S + V56T + R87S + G109A + A174S + G182* + D183* + N195F + V206L + K391A + G476K,

T40G + N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + K391A + G476K,

T51K + N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + K391A + G476K,

N54S + V56T + K72R + G109A + A174S + G182* + D183* + N195F + V206L + K391A + G476K,

N54S + V56T + K72H + G109A + A174S + G182* + D183* + N195F + V206L + K391A + G476K,

A37H + N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + K391A + G476K,

A37M + N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + K391A + G476K,

A37V + N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + K391A + G476K,

A37S + N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + K391A + G476K,

A37Y + N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + K391A + G476K,

A37R + N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + K391A + G476K,

N54S + V56T + G109A + F113W + A174S + G182* + D183* + N195F + V206L + K391A + G476K,

N54S + V56T + G109A + F113S + A174S + G182* + D183* + N195F + V206L + K391A + G476K,

N54S + V56T + G109A + F113N + A174S + G182* + D183* + N195F + V206L + K391A + G476K,

N54S + V56T + G109A + F113Y + A174S + G182* + D183* + N195F + V206L + K391A + G476K,

N54S + V56T + G109A + Q118N + A174S + G182* + D183* + N195F + V206L + K391A + G476K,

N54S + V56T + G109A + R116Q + A174S + G182* + D183* + N195F + V206L + K391A + G476K,

N54S + V56T + G109A + R116V + A174S + G182* + D183* + N195F + V206L + K391A + G476K,

N54S + V56T + G109A + R116K + A174S + G182* + D183* + N195F + V206L + K391A + G476K,

N54S + V56T + G109A + R116W + A174S + G182* + D183* + N195F + V206L + K391A + G476K,

N54S + V56T + G109A + R116L + A174S + G182* + D183* + N195F + V206L + K391A + G476K,

N54S + V56T + G109A + G142T + A174S + G182* + D183* + N195F + V206L + K391A + G476K,

N54S + V56T + G109A + Q125P + A174S + G182* + D183* + N195F + V206L + K391A + G476K,

N54S + V56T + G109A + Q125K + A174S + G182* + D183* + N195F + V206L + K391A + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + S381G + K391A + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + M246T + K391A + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + V213T + K391A + G476K,

A37L + N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + K391A + G476K,

N54S + V56T + G109A + Q118K + A174S + G182* + D183* + N195F + V206L + K391A + G476K,

N54S + V56T + G109A + R116A + A174S + G182* + D183* + N195F + V206L + K391A + G476K,

N54S + V56T + G109A + R116H + A174S + G182* + D183* + N195F + V206L + K391A + G476K,

N54S + V56T + G109A + Q125A + A174S + G182* + D183* + N195F + V206L + K391A + G476K,

N54S + V56T + G109A + Q172G + A174S + G182* + D183* + N195F + V206L + K391A + G476K,

N54S + V56T + G109A + Q172R + A174S + G182* + D183* + N195F + V206L + K391A + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + D377S + K391A + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + D377G + K391A + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + D377R + K391A + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + D377A + K391A + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + I214G + K391A + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + S381A + K391A + G476K,

N54S + V56T + G109A + W167I + A174S + G182* + D183* + N195F + V206L + K391A + G476K,

N54S + V56T + G109A + W167G + A174S + G182* + D183* + N195F + V206L + K391A + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + G346S + K391A + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + G346P + K391A + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + I214H + K391A + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + I214S + K391A + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + I214T + K391A + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + K391A + A420Q + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + K391A + A420S + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + K391A + A420K + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + K391A + A420L + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + K391A + K391Y + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + K391A + K391R + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + K391A + P473R + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + K391A + P473A + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + K391A + P473G + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + K391A + P473T + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + K391A + Q395P + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + K391A + T444Q + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + K391A + T444S + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + K391A + T444D + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + K391A + T444Y + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + S280W + K391A + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + S280L + K391A + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + S280T + K391A + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + S280A + K391A + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + G255N + K391A + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + T285L + K391A + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + T285Q + K391A + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + K391A + Q449T + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + K391A + P473K + G476K,

N54S + V56T + K72S + G109A + A174S + G182* + D183* + N195F + V206L + K391A + G476K,

T40K + N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + G346T + K391A + 

G476K,

G50A + N54S + V56T + G109A ++ Q172N + A174S + G182* + D183* + N195F + V206L + K391A + 

G476K, 

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + K391A + G476K + K484A,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + K391A + G476K + K484G,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + K391A + G476K + K484P,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + K391A + G476K + K484E,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + K391A + G476K + K484Q,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + K391A + G476K + K484S,

H1*K + G50A + N54S + V56T + G109A + W167F + A174S + G182* + D183* + N195F + V206L + K391A + 

G476K,

N54S + V56T + G109A + L173V + A174S + G182* + D183* + N195F + A204T + V206L + K391A + 

G476K,

N54S + V56T + G109A + W140Y + A174S + G182* + D183* + N195F + V206L + K391A + G476K,

N54S + V56T + Q98S + G109A + A174S + G182* + D183* + N195F + V206L + R320A + K391A + 

G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + H324L + K391A + G476K,

N54S + V56T + G109A + G149Q + A174S + G182* + D183* + N195F + V206L + K391A + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + G346T + K391A + G476K + 

G477A,

N54S + V56T + G109AG255A ++ A174S + G182* + D183* + N195F + V206L + K391A + G476K,

G50A + N54S + V56T + G109A + F113L + R116L + A174S + G182* + D183* + N195F + V206L + 

K391A + G476K,

N54S + V56T + G109A + W167F + A174S + G182* + D183* + N195F + V206L + K391A + G476K,

N54S + V56T + G109A + L173V + A174S + G182* + D183* + N195F + V206L + K391A + G476K,

N54S + V56T + K72R + G109A + W167F + A174S + G182* + D183* + N195F + V206L + K391A + 

G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + K391A + G476K + G477Q,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + Q345D + K391A + G476K + 

G477Q,

G50A + N54S + V56T + G109A + Q172D + A174S + G182* + D183* + N195F + V206L + K391A + 

G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + V264I + K391A + G423H + 

G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + R320V + K391A + G476Y,

T5K + N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + K391A + G476K,

N54S + V56T + G109A + R116M + A174S + G182* + D183* + N195F + V206L + K391A + G476K,

N54S + V56T + G109A + Q172Y + A174S + G182* + D183* + N195F + V206L + K391A + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + I214L + K391A + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + L217V + K391A + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + L217H + K391A + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + P211D + K391A + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + K391A + K391Q + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + K391A + T444H + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + K391A + T444V + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + K391A + T444R + G476K,

G50A + N54S + V56T + G109A + L173V + A174S + G182* + D183* + N195F + A204V + V206L + 

K391A + G476K,

G50A + N54S + V56T + G109A + F113L + W167F + A174S + G182* + D183* + N195F + V206L + 

K391A + G476K,

G7K + N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + R320A + K391A + G476K,

N54S + V56T + G109A + Q118G + A174S + G182* + D183* + N195F + V206L + K391A + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + S280K + K391A + G476K,

N54S + V56T + G109A + Q172D + A174S + G182* + D183* + N195F + V206L + G346T + K391A + 

G476K + G477A,

N54S + V56T + G109A + Q118S + A174S + G182* + D183* + N195F + V206L + K391A + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + R320A + K391A + G476K,

N54S + V56T + G109A + T134E + A174S + G182* + D183* + N195F + V206L + K391A + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + G337H + Q385L + K391A + 

G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + Y382M + K391A + G476K,

N54S + V56T + K72R + G109A + A174S + G182* + D183* + N195F + V206L + G255A + D377H + 

K391A + G476K,

N54S + V56T + K72R + G109A + T134E + A174S + G182* + D183* + N195F + V206L + G255A + 

K391A + G476K,

N54S + V56T + K72R + M105F + G109A + A174S + G182* + D183* + N195F + V206L + G255A + 

K391A + G476K,

N54S + V56T + M105F + G109A + T134E + A174S + G182* + D183* + N195F + V206L + K391A + 

G476K,

N54S + V56T + M105F + G109A + Q118F + T134E + A174S + G182* + D183* + N195F + V206L + 

K391A + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + R320A + S323N + D377H + 

K391A + G476K,

T51E + N54S + V56T + G109A + A174H + G182* + D183* + N195F + V206L + K391A + G476K,

N54S + V56T + G109A + L173A + A174S + G182* + D183* + N195F + V206L + K391A + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + Q299V + K391A + G476K,

N54S + V56T + G109A + L173G + A174S + G182* + D183* + N195F + V206L + K391A + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + T355L + K391A + G476K,

G50A + N54S + V56T + G109A + A174S + G182* + D183* + N195F + A204T + V206L + K391A + 

G476K,

G50A + N54S + V56T + G109A + A174E + G182* + D183* + N195F + A204T + V206L + K391A + 

G476K,

N54S + V56T + K72R + G109A + A174S + G182* + D183* + N195F + V206L + R320A + S323N + 

K391A + G476K,

N54S + V56T + M105I + G109A + A174S + G182* + D183* + N195F + V206L + K391A + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + M246L + K391A + G476K,

T51G + N54S + V56T + G109A + A174N + G182* + D183* + N195F + V206L + K391A + G476K,

N54S + V56T + G109A + A174D + G182* + D183* + N195F + V206L + K391A + G476K,

T51S + N54S + V56T + G109A + A174P + G182* + D183* + N195F + V206L + K391A + G476K,

N54S + V56T + K72A + G109A + W167S + A174S + G182* + D183* + N195F + V206L + K391A + 

G476K,

N54S + V56T + K72Q + G109A + W167H + A174S + G182* + D183* + N195F + V206L + K391A + 

G476K,

N54S + V56T + G109A + Q118R + T134E + A174S + G182* + D183* + N195F + V206L + D377H + 

K391A + G476K,

Q11H + N54S + V56T + G109A + Q118R + T134E + A174S + G184T + G182* + D183* + N195F + 

V206L + D377H + K391A + G476K,

N54S + V56T + K72R + G109A + T134E + A174S + G182* + D183* + N195F + V206L + K391A + 

G476K,

N54S + V56T + K72R + G109A + T134E + A174S + G182* + D183* + N195F + V206L + D377H + 

K391A + G476K,

N54S + V56T + K72R + G109A + T134E + A174S + G182* + D183* + G184T + N195F + V206L + 

K391A + G476K,

N54S + V56T + G109A + Q118R + T134E + A174S + G182* + D183* + N195F + V206L + G255A + 

K391A + G476K,

N54S + V56T + G109A + Q118R + A174S + G182* + D183* + N195F + V206L + D377H + K391A + 

G476K,

N54S + V56T + G109A + T134E + A174S + G182* + D183* + G184T + N195F + V206L + D377H + 

K391A + G476K,

N54S + V56T + G109A + Q172D + A174Q + G182* + D183* + N195F + V206L + K391A + G476K + 

G477A,

N54S + V56T + K72R + G109A + W167L + A174S + G182* + D183* + N195F + V206L + K391A + 

G476K,

N54S + V56T + K72R + G109A + W167M + A174S + G182* + D183* + N195F + V206L + K391A + 

G476K,

N54S + V56T + K72R + G109A + A174S + G182* + D183* + G184T + N195F + V206L + G255A + 

K391A + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + G184T + N195F + V206L + D377H + K391A + 

G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + G255A + D377H + K391A + 

G476K,

N54S + V56T + M105F + G109A + A174S + G182* + D183* + G184T + N195F + V206L + K391A + 

G476K,

N54S + V56T + G109A + T134E + A174S + G182* + D183* + N195F + V206L + R320A + S323N + 

K391A + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + V291G + D377H + K391A + 

G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + V291A + F328L + D377H + 

K391A + G476K,

N54S + V56T + G109A + T134E + A174S + G182* + D183* + G184T + N195F + V206L + K391A + 

G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + V238A + D377H + K391A + 

G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + V238T + D377H + K391A + 

G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + V238G + D377H + K391A + 

G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + F328M + D377H + K391A + 

G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + F328L + D377H + K391A + 

G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + F328V + D377H + K391A + 

G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + F328I + D377H + K391A + 

G476K,

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G476K,

N54S + V56T + G109A + L173V + A174R + G182* + D183* + N195F + V206L + K391A + G476K,

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G476K,

N54S + V56T + G109A + W167Y + Q172E + L173V + A174H + G182* + D183* + N195F + V206L + 

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N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + V291A + F328L + K391A + 

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N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + M246L + K391A + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + M246S + K391A + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + L250V + K391A + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + L250F + K391A + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + L250M + K391A + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + K391A + C474V + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + A204S + V206L + K391A + G476K,

N54S + V56T + G109A + T165G + A174S + G182* + D183* + N195F + V206L + K391A + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + T334S + K391A + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + A263G + M286L + K391A + 

G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + Y267H + K391A + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + Y267L + K391A + G476K,

T51A + N54S + V56T + G109A + Q172R + A174S + G182* + D183* + N195F + V206L + K391A + 

G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + K391L + G476K,

N54S + V56T + G109A + F113Q + R116H + Q172G + A174S + G182* + D183* + N195F + V206L + 

K391A + G476K,

N54S + V56T + G109A + F113Q + Q172G + A174S + G182* + D183* + N195F + V206L + K391A + 

G476K,

N54S + V56T + G109S + F113Q + R116Q + A174S + G182* + D183* + N195F + V206L + K391A + 

G476K,

N54S + V56T + G109A + Q172D + A174S + G182* + D183* + N195F + A204G + V206L + K391A + 

P473R + G476K,

N54S + V56T + K72R + G109A + T134E + A174S + G182* + D183* + N195F + A204G + V206L + 

G255A + K391A + P473R + G476K,

N54S + V56T + K72R + G109A + W167F + A174S + G182* + D183* + N195F + A204G + V206L + 

K391A + G476K,

N54S + V56T + K72R + G109A + A174S + G182* + D183* + G184T + N195F + A204G + V206L + 

K391A + P473R + G476K,

N54S + V56T + G109A + W167F + Q172N + A174S + G182* + D183* + N195F + V206L + K391A + 

P473R + G476K,

N54S + V56T + G109A + W167F + Q172G + A174S + G182* + D183* + N195F + V206L + K391A + 

P473G + G476K,

N54S + V56T + G109A + W167F + Q172G + A174S + G182* + D183* + N195F + V206L + K391A + 

P473R + G476K,

N54S + V56T + K72R + G109A + W167F + Q172R + A174S + G182* + D183* + N195F + V206L + 

K391A + G476K,

N54S + V56T + K72R + G109A + R116H + W167F + Q172R + A174S + G182* + D183* + N195F + 

V206L + K391A + G476K,

N54S + V56T + M105F + G109A + A174S + G182* + D183* + N195F + V206L + R320A + S323N + 

K391A + C474V + G476K,

N54S + V56T + K72R + G109A + A174S + G182* + D183* + N195F + V206L + G255A + K391A + 

C474V + G476K,

N54S + V56T + G109A + T134E + A174S + G182* + D183* + N195F + V206L + K391A + C474V + 

G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + D377H + K391A + C474V + 

G476K,

N54S + V56T + K72R + G109A + A174S + G182* + D183* + N195F + V206L + K391A + C474V + 

G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + A265G + K391A + T444Q + 

G476K + G477A,

A37V + N54S + V56T + G109A + W167F + Q172G + A174S + G182* + D183* + N195F + V206L + 

K391A + G346T + G477A + G476K,

N54S + V56T + G109A + R116Q + Q172D + A174S + G182* + D183* + N195F + V206L + G346T + 

K391A + T444Q + G477A + G476K,

N54S + V56T + G109A + R116Q + W167F + Q172N + A174S + G182* + D183* + N195F + 

V206L + G346T + K391A + T444Q + G477A + G476K,

N54S + V56T + G109S + W167F + Q172R + A174S + G182* + D183* + N195F + V206L + K391A + 

G476K,

N54S + V56T + G109S + R116Q + W167F + Q172N + A174S + G182* + D183* + N195F + 

V206L + K391A + G476K,

N54S + V56T + G109S + W167F + Q172G + A174S + G182* + D183* + N195F + V206L + K391A + 

G476K,

N54S + V56T + G109A + F113Q + Q172G + A174S + G182* + D183* + N195F + V206L + K391A + 

T444Q + G476K,

N54S + V56T + G109A + F113Q + R116H + Q172G + A174S + G182* + D183* + N195F + V206L + 

K391A + T444Q + G476K,

N54S + V56T + G109A + F113Q + A174S + G182* + D183* + N195F + V206L + K391A + C474V + 

G476K,

N54S + V56T + G109A + Q172N + A174S + G182* + D183* + N195F + V206L + V264I + K391A + 

C474V + G476K,

N54S + V56T + G109A + Q172N + A174S + G182* + D183* + N195F + V206L + K391A + C474V + 

G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + S280Q + H321Y + K391A + 

C474V + G476K,

N54S + V56T + K72R + G109A + T134E + A174S + G182* + D183* + N195F + V206L + G255A + 

K391A + C474V + G476K,

N54S + V56T + G109A + F113Q + R116H + Q172G + A174S + G182* + D183* + N195F + V206L + 

K391A + T444Q + P473R + G476K,

N54S + V56T + G109A + F113Q + R116Q + Q172G + A174S + G182* + D183* + N195F + V206L + 

K391A + T444Q + G476K,

N54S + V56T + G109A + R116H + W167F + Q172N + A174S + G182* + D183* + N195F + V206L + 

K391A + G476K,

N54S + V56T + G109A + F113Q + R116H + T165G + Q172G + A174S + G182* + D183* + 

N195F + V206L + K391A + T444Q + G476K,

N54S + V56T + G109A + F113Q + R116Q + T165G + Q172G + A174S + G182* + D183* + 

N195F + V206L + K391A + T444Q + G476K,

N54S + V56T + G109A + F113Q + R116H + W167F + Q172R + A174S + G182* + D183* + 

N195F + V206L + F289I + K391A + G476K,

N54S + V56T + G109A + F113Q + Q172N + A174S + G182* + D183* + N195F + V206L + K391A + 

T444Q + G476K,

N54S + V56T + G109A + F113Q + R116H + Q172N + A174S + G182* + D183* + N195F + V206L + 

K391A + G476K,

N54S + V56T + G109A + F113Q + R116Q + Q172M + A174S + G182* + D183* + N195F + V206L + 

K391A + T444Q + G476K,

N54S + V56T + G109A + F113Q + R116H + Q172M + A174S + G182* + D183* + N195F + V206L + 

K391A + G476K,

N54S + V56T + G109A + R116H + Q172M + A174S + G182* + D183* + N195F + V206L + K391A + 

G476K,

N54S + V56T + G109A + F113Q + R116H + T165G + Q172M + A174S + G182* + D183* + 

N195F + V206L + K391A + Q395P + G476K,

N54S + V56T + G109A + F113Q + A174S + G182* + D183* + N195F + V206L + K391A + T444Q + 

P473R + G476K,

N54S + V56T + G109A + R116Q + A174S + G182* + D183* + N195F + V206L + A265G + K391A + 

T444Q + P473R + G476K,

N54S + V56T + G109A + R116Q + A174S + G182* + D183* + N195F + V206L + K391A + T444Q + 

P473R + G476K,

N54S + V56T + K72R + G109A + T134E + T165G + A174S + G182* + D183* + N195F + V206L + 

G255A + K391A + G476K,

N54S + V56T + G109A + F113Q + R116H + W167F + Q172R + A174S + G182* + D183* + 

N195F + V206L + K391A + G476K,

N54S + V56T + G109A + R116Q + W167F + Q172R + A174S + G182* + D183* + N195F + 

V206L + A265G + K391A + P473R + G476K,

N54S + V56T + G109A + F113Q + A174S + G182* + D183* + N195F + V206L + K391A + G476K,

N54S + V56T + G109A + Q172N + A174S + G182* + D183* + N195F + V206L + K391A + G476K,

T51V + N54S + V56T + G109A + Q172D + A174S + G182* + D183* + N195F + V206L + K391A + 

G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + S280Q + H321Y + K391A + 

G476K,

N54S + V56T + G109A + F113Q + R116H + Q172N + A174S + G182* + D183* + N195F + V206L + 

K391A + G476K,

N54S + V56T + G109A + F113Q + R116H + Q172G + L173V + A174S + G182* + D183* + N195F + 

V206L + K391A + T444Q + P473R + G476K,

N54S + V56T + G109A + R116Q + W167F + Q172N + L173V + A174S + G182* + D183* + 

N195F + V206L + K391A + T444Q + G476K,

N54S + V56T + G109A + G133Q + W167F + Q172N + A174S + G182* + D183* + N195F + 

V206L + Q395P + K391A + G476K,

N54S + V56T + G109A + F113Q + R116H + W167F + Q172N + L173V + A174S + G182* + 

D183* + N195F + V206L + K391A + G476K,

A37V + N54S + V56T + K72R + G109A + R116H + W167F + Q172R + A174S + G182* + D183* + 

G184T + N195F + V206L + K391A + P473R + G476K,

N54S + V56T + K72R + G109A + F113Q + R116H + W167F + Q172G + L173V + A174S + G182* + 

D183* + G184T + N195F + V206L + K391A + T444Q + P473R + G476K,

N54S + V56T + G109S + R116Q + W167F + Q172R + A174S + G182* + D183* + N195F + 

V206L + K391A + G476K,

N54S + V56T + G109S + R116Q + W167F + Q172G + A174S + G182* + D183* + N195F + 

V206L + K391A + P473R + G476K,

N54S + V56T + G109S + F113Q + W167F + Q172N + A174S + G182* + D183* + N195F + V206L + 

K391A + G476K,

A37V + N54S + V56T + G109S + F113Q + W167F + Q172R + A174S + G182* + D183* + N195F + 

V206L + K391A + G476K,

N54S + V56T + K72R + G109A + R116H + T134E + W167F + Q172G + L173V + A174S + G182* + 

D183* + N195F + V206L + G255A + K391A + G476K,

N54S + V56T + K72R + G109A + R116H + T134E + W167F + Q172G + L173V + A174S + G182* + 

D183* + N195F + V206L + G255A + K391A + Q395P + T444Q + P473R + G476K,

N54S + V56T + K72R + G109A + F113Q + R116Q + W167F + Q172G + A174S + G182* + D183* + 

G184T + N195F + V206L + K391A + P473R + G476K,

N54S + V56T + K72R + G109A + F113Q + R116Q + T134E + W167F + Q172R + A174S + G182* + 

D183* + N195F + V206L + G255A + K391A + T444Q + P473R + G476K,

N54S + V56T + K72R + G109A + F113Q + T134E + W167F + Q172R + A174S + G182* + D183* + 

N195F + V206L + G255A + K391A + Q395P + A445Q + P473R + G476K,

N54S + V56T + K72R + G109A + F113Q + R116H + T134E + W167F + Q172R + A174S + G182* + 

D183* + N195F + V206L + G255A + K391A + Q395P + G476K,

N54S + V56T + K72R + G109A + T134E + W167F + Q172N + A174S + G182* + D183* + N195F + 

V206L + G255A + A265G + K391A + T444Q + P473R + G476K,

N54S + V56T + K72R + G109A + G133Q + W167F + Q172R + A174S + G182* + D183* + N195F + 

V206L + K391A + G476K,

N54S + V56T + K72R + G109A + F113Q + R116Q + W167F + Q172G + A174S + G182* + D183* + 

N195F + A204G + V206L + K391A + G476K,

N54S + V56T + K72R + G109A + F113Q + R116Q + W167F + Q172N + L173V + A174S + G182* + 

D183* + G184T + N195F + V206L + K391A + T444Q + P473R + G476K,

A37H + N54S + V56T + G109A + F113Q + W167F + Q172N + A174S + G182* + D183* + N195F + 

V206L + K391A + G476K,

A37H + N54S + V56T + G109A + F113Q + A174S + G182* + D183* + N195F + V206L + K391A + 

G476K,

N54S + V56T + G109A + F113Q + W167F + Q172N + A174S + G182* + D183* + N195F + V206L + 

K391A + T459N + G476K,

N54S + V56T + G109A + F113Q + Q172R + L173V + A174S + G182* + D183* + N195F + V206L + 

K391A + T444Q + G476K,

N54S + V56T + G109A + F113Q + R116Q + A174S + G182* + D183* + N195F + V206L + K391A + 

P473R + G476K,

N54S + V56T + A60V + G109A + R116Q + W167F + Q172N + A174S + G182* + D183* + N195F + 

V206L + K391A + G476K,

N54S + V56T + A60V + G109A + R116H + Q172R + L173V + A174S + G182* + D183* + N195F + 

V206L + K391A + G476K,

A37V + N54S + V56T + A60V + G109A + R116Q + T165G + A174S + G182* + D183* + N195F + V206L + K3

91A + G476K,

A37H + N54S + V56T + A60V + G109A + R116Q + T165G + A174S + G182* + D183* + N195F + V206L + K3

91A + G476K,

N54S + V56T + A60V + G109A + R116Q + W167F + Q172G + L173V + A174S + G182* + D183* + 

N195F + V206L + K391A + G476K,

N54S + V56T + A60V + G109A + R116Q + A174S + G182* + D183* + N195F + V206L + K391A + 

G476K,

A37H + N54S + V56T + A60V + G109A + R116Q + W167F + Q172R + A174S + G182* + D183* + 

N195F + V206L + K391A + G476K,

A37H + N54S + V56T + A60V + G109A + R116Q + W167F + Q172N + A174S + G182* + D183* + 

N195F + V206L + K391A + G476K,

N54S + V56T + A60V + G109A + R116Q + T165G + A174S + G182* + D183* + N195F + V206L + 

K391A + T444Q + P473R + G476K,

N54S + V56T + A60V + G109A + R116Q + A174S + G182* + D183* + N195F + V206L + K391A + 

T444Q + P473R + G476K,

N54S + V56T + A60V + G109A + R116Q + W167F + Q172N + L173V + A174S + G182* + D183* + 

N195F + V206L + K391A + G476K,

N54S + V56T + A60V + G109A + R116Q + W167F + Q172R + A174S + G182* + D183* + N195F + 

V206L + K391A + G476K,

N54S + V56T + G109A + R116A + W167F + Q172R + A174S + G182* + D183* + N195F + 

A204G + V206L + K391A + P473R + G476K,

N54S + V56T + G109A + R116A + A174S + G182* + D183* + N195F + A204G + V206L + K391A + 

P473R + G476K,

N54S + V56T + G109A + R116A + T165G + A174S + G182* + D183* + N195F + V206L + K391A + 

T444Q + P473R + G476K,

G109A + A174S + G182* + D183* + N195F + V206L + K391A + G476K,

N54S + V56T + G109A + G182* + D183* + N195F + V206L + K391A + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + K391A,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + G476K,

N54S + V56T + A174S + G182* + D183* + N195F + V206L + G273R + K391A + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L,

W48G + G109A + G182* + D183* + N195F + V206L + K391A + G476K,

N54S + V56T + G109A + F113Q + Q172M + A174S + G182* + D183* + N195F + V206L + K391A + 

G476K,

N54S + V56T + G109A + R116Q + A174S + G182* + D183* + N195F + A204G + V206L + K391A + 

G476K,

N54S + V56T + K72R + G109A + F113Q + T134E + A174S + G182* + D183* + N195F + V206L + 

G255A + K391A + G476K,

N54S + V56T + K72R + G109A + F113Q + T134E + A174S + G182* + D183* + N195F + V206L + 

G255A + K391A + P473R + G476K,

N54S + V56T + K72R + G109A + R116Q + A174S + G182* + D183* + G184T + N195F + V206L + 

K391A + G476K,

A37V + N54S + V56T + G109A + R116A + T165G + A174S + G182* + D183* + N195F + V206L + 

K391A + G476K,

A37V + N54S + V56T + G109A + R116Q + T165G + A174S + G182* + D183* + N195F + V206L + 

M246F + K391A + G476K,

V56A + G109A + A174S + G182* + D183* + N195F + V206L + G476K,

N54S + V56T + K72R + G109A + F113Q + R116H + A174S + G182* + D183* + G184T + N195F + 

V206L + K391A + T444Q + G476K,

N54S + V56T + G109S + F113Q + A174S + G182* + D183* + N195F + V206L + K391A + T444Q + 

G476K,

N54S + V56T + G109A + F113Q + R116H + W167F + Q172G + L173V + A174S + G182* + 

D183* + N195F + V206L + K391A + P473R + G476K,

N54S + V56T + G109A + F113Q + R116Q + Q172N + A174S + G182* + D183* + N195F + V206L + 

A265G + K391A + P473R + G476K,

N54S + V56T + G109A + F113Q + W167F + Q172N + A174S + G182* + D183* + N195F + 

A204G + V206L + K391A + P473R + G476K,

N54S + V56T + G109A + F113Q + R116H + W167F + Q172R + A174S + G182* + D183* + 

N195F + A204G + V206L + K391A + P473R + G476K,

N54S + V56T + G109A + R116A + A174S + G182* + D183* + N195F + V206L + K391A + T444Q + 

P473R + G476K,

N54S + V56T + G109A + R116H + Q172R + A174S + G182* + D183* + N195F + A204G + V206L + 

K391A + P473R + G476K,

A37V + N54S + V56T + G109A + R116Q + T165G + A174S + G182* + D183* + N195F + V206L + 

K391A + G476K,

A37H + N54S + V56T + G109A + R116H + T165G + A174S + G182* + D183* + N195F + V206L + 

M246F + K391A + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + K391A + G476K,

N54S + V56T + G109A + G133S + A174S + G182* + D183* + N195F + K391A + G476H,

N54S + V56T + G109A + R116A + Q172N + L173V + A174S + G182* + D183* + N195F + V206L + 

K391A + G476K,

A37V + N54S + V56T + G109A + R116H + T165G + A174S + G182* + D183* + N195F + V206L + 

K391A + G476K,

P45A + N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + K391A + C474V + 

G476K,

N54S + V56T + G109A + P124A + A174S + G182* + D183* + N195F + V206L + K391A + C474V + 

G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + P364A + K391A + C474V + 

G476K,

N54S + V56T + G109A + Q118R + T134E + A174S + G182* + D183* + N195F + V206L + K391A + 

G476K,

N54S + V56T + G109A + A174S + G182* + D183* + G184T + N195F + V206L + K391A + G476K,

G50A + T51A + N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + K391A + 

G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + V264F + K391A + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + Y382L + K391A + G476K,

G7K + N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + K391A + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + G255A + Q256A + K391A + 

G476K,

N54S + V56T + G109A + W167Y + A174S + G182* + D183* + N195F + V206L + K391A + G476K,

N54S + V56T + G109A + W167H + A174S + G182* + D183* + N195F + V206L + K391A + G476K,

N54S + V56T + G109A + T165V + A174S + G182* + D183* + N195F + V206L + K391A + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + K391A + G476K,

N54S + V56T + G109A + A174N + G182* + D183* + N195F + V206L + K391A + G476K,

N54S + V56T + G109A + A174Q + G182* + D183* + N195F + V206L + K391A + G476K,

N16H + V17L + N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + Y382F + 

K391A + G476K,

Q32S + N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + Q385L + K391A + 

G476K,

N54S + V56T + R87S + G109A + R171H + A174S + G182* + D183* + N195F + V206L + K391A + 

G476K,

N54S + V56T + G109A + R116H + Q169E + Q172K + A174* + G182* + D183* + N195F + V206L + 

K391A + G476K,

N54S + V56T + G109A + A174* + G182* + D183* + N195F + V206L + K391A + G476K,

K72R + G109A + F113Q + R116Q + W167F + Q172G + A174S + G182* + D183* + G184T + 

N195F + V206L + K391A + P473R + G476K,

N54S + V56T + K72R + G109A + F113Q + R116Q + W167F + Q172G + A174S + G182* + D183* + 

G184T + N195F + V206L + P473R + G476K,

N54S + V56T + G109A + Q169E + Q172G + A174* + G182* + D183* + N195F + V206L + K391A + 

G476K,

N54S + V56T + K72R + G109A + F113Q + R116Q + W167F + Q172G + A174S + G182* + D183* + 

G184T + N195F + K391A + P473R + G476K,

N54S + V56T + G109A + R116W + Q169E + Q172K + A174* + G182* + D183* + N195F + V206L + 

K391A + G476K,

N54S + V56T + G109A + Q169E + Q172K + A174* + G182* + D183* + N195F + V206F + K391A + 

G476K,

V56T + G109A + A174S + G182* + D183* + N195F + V206L + K391A + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + N260G + K391A + G476K,

N54S + V56T + K72R + G109A + A174S + G182* + D183* + N195F + V206L + K391A + G476K,

N54S + V56T + G109A + Q169E + Q172K + A174* + G182* + D183* + G184T + N195F + V206L + 

K391A + G476K,

N54S + V56T + G109A + Q169E + Q172K + A174* + G182* + D183* + N195F + V206L + Y295N + 

K391A + G476K,

N54S + V56T + G109A + W167F + A174S + G182* + D183* + N195F + V206L + K391A + G476K,

N54S + V56T + G109A + Q169E + Q172K + A174* + G182* + D183* + A186N + N195F + V206L + 

K391A + G476K,

N54S + V56T + G109A + Q169E + Q172K + A174* + G182* + D183* + N195F + V206L + A288V + 

K391A + G476K,

N54S + V56T + G109A + Q169E + Q172K + A174* + G182* + D183* + N195F + V206L + G255A + 

K391A + G476K,

N54S + G109A + Q169E + Q172K + A174* + G182* + D183* + N195F + V206L + K391A + G476K,

W48F + N54S + V56T + G109A + Q169E + Q172K + A174* + G182* + D183* + N195F + V206L + 

K391A + G476K,

N54S + V56T + G109A + Q169E + Q172K + A174* + G182* + D183* + N195F + V206L + V291A + 

K391A + G476K,

N54S + V56T + G109A + F113Q + A174S + G182* + D183* + N195F + V206L + K391A + G476K,

N54S + V56T + G109A + Q169E + Q172K + A174* + G182* + D183* + N195F + V206L + R320A + 

S323N + K391A + G476K,

V56T + G109A + Q169E + Q172K + A174* + G182* + D183* + N195F + V206L + K391A + G476K,

N54S + V56T + K72R + G109A + F113Q + R116H + W167F + Q172G + A174S + G182* + D183* + 

G184T + N195F + V206L + K391A + P473R + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + N270T + K391A + G476K,

N54S + V56T + G109A + Q169E + Q172K + A174* + G182* + D183* + N195F + V206L + G476K,

N54S + V56T + G109A + Q169E + Q172K + A174* + G182* + D183* + N195F + V206L + N260G + 

K391A + G476K,

N54S + V56T + G109A + F113Q + R116H + A174S + G182* + D183* + N195F + V206L + K391A + 

G476K,

N54S + V56T + G109A + Q172G + A174S + G182* + D183* + N195F + V206L + K391A + G476K,

N54S + V56T + G109A + A174S + A186D + G182* + D183* + N195F + V206L + K391A + G476K,

N54S + V56T + G109A + Q169E + Q172K + A174* + G182* + D183* + N195F + V206L + A225V + 

K391A + G476K,

G109A + Q169E + Q172K + A174* + G182* + D183* + N195F + V206L + K391A + G476K,

N54S + V56T + G109A + Q169E + Q172K + A174* + G182* + D183* + N195F + V206L + G255S + 

K391A + G476K,

N54S + V56T + G109A + Q169E + Q172K + A174* + G182* + D183* + N195F + V206L + K269Q + 

K391A + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + G255S + K391A + G476K,

N54S + V56T + G109A + Q169E + Q172K + A174S + G182* + D183* + N195F + V206L + K391A + 

G476K,

N54S + V56T + G109A + Q169E + A174S + G182* + D183* + N195F + V206L + K391A + G476K,

N54S + V56T + G109A + Q169E + Q172K + A174* + G182* + D183* + N195F + V206L + W284H + 

K391A + G476K,

N54S + G109A + A174S + G182* + D183* + N195F + V206L + K391A + G476K,

N54S + V56T + G109A + Q169E + Q172K + A174* + G182* + D183* + N195F + V206L + S304R + 

K391A + G476K,

N54S + V56T + K72R + G109A + F113Q + R116Q + W167F + Q172G + A174S + G182* + D183* + 

G184T + N195F + V206L + K391A + P473R,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + M246V + K391A + G476K,

N54S + V56T + G109A + Q169E + Q172K + A174* + G182* + D183* + N195F + V206L + K391A,

N54S + V56T + G109A + Q169E + Q172K + A174* + G182* + D183* + N195F + V206L + N270G + 

K391A + G476K,

N54S + V56T + G109A + Q169E + Q172K + A174* + G182* + D183* + N195F + V206L + Y295F + 

K391A + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + R320A + K391A + G476K,

N54S + V56T + G109A + Q169E + Q172K + A174T + G182* + D183* + N195F + V206L + K391A + 

G476K,

N54S + V56T + G109A + W140Y + Q169E + Q172K + A174* + G182* + D183* + N195F + V206L + 

K391A + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + K391A,

N54S + V56T + G109A + Q169E + Q172K + A174* + G182* + D183* + N195F + V206L + F328L + 

K391A + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + A288L + K391A + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + N270G + K391A + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + K269Q + K391A + G476K,

W48F + N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + K391A + G476K,

N54S + V56T + G109A + A174T + G182* + D183* + N195F + V206L + K391A + G476K,

N54S + V56T + G109A + R116W + A174S + G182* + D183* + N195F + V206L + K391A + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + V238A + K391A + G476K,

N54S + V56T + G109A + A174S + V206L + G182* + D183* + K391A + G476K,

N54S + V56T + Q169E + Q172K + A174* + G182* + D183* + N195F + V206L + K391A + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206F + K391A + G476K,

N54S + V56T + G109A + Q172K + A174S + G182* + D183* + N195F + V206L + K391A + G476K,

N54S + V56T + G109A + Q172K + A174* + G182* + D183* + N195F + V206L + K391A + G476K,

N54S + V56T + G109A + A174N + G182* + D183* + N195F + V206L + K391A + G476K,

N54S + V56T + G109A + A174S + A186N + G182* + D183* + N195F + V206L + K391A + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + F289L + K391A + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + K391A + G476K,

G109A + A174S + G182* + D183* + N195F + V206L + K391A + G476K,

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + Y295F + K391A + G476K, or

N54S + V56T + G109A + A174S + G182* + D183* + N195F + V206L + V291A + K391A + G476K,

wherein the positions correspond to SEQ ID NO: 13.