Patent ID: 11878047
Assignee: SILENCE THERAPEUTICS GMBH
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 3:
4. A cell-penetrating ATF5 peptide comprising a variant of the amino acid sequence RQIKIWFQNRRMKWKKLEGECQGLEARNRELKERAESV (SEQ ID NO: 3), wherein the variant is modified at positions of SEQ ID NO: 3 selected from the group consisting of:, (i)

(SEQ ID NO: 4)

C21G;

 

(ii)

(SEQ ID NO: 5)

 

C21A;

 

(iii)

(SEQ ID NO: 8)

Q22A;

 

(iv)

(SEQ ID NO: 9)

E20R, E25R, R27E, and K32E;

 

(v)

(SEQ ID NO: 7)

N28L;

 

(vi)

(SEQ ID NO: 6)

S37A;

 

(vii)

(SEQ ID NO: 10)

E20R, E25R, R27E, N28L, K32E, and S37A;

and

 

(viii)

(SEQ ID NO: 11)

E20R, C21A, E25R, R27E, N28L, K32E, and S37A.