Patent ID: 11891389
Assignee: MYOFORTE THERAPEUTICS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC C

Claim 0:
1. A method of treating muscle disorder, muscle injury or muscle atrophy in a patient in need thereof, the method comprising administering to the patient a compound having the structure of Formula IIq:, or a pharmaceutically acceptable salt thereof, wherein:
R1 is selected from C6-10aryl and 5- to 10-membered heteroaryl; wherein said aryl or heteroaryl is optionally substituted with 1 to 3 substituents each independently selected from halo, —NR6R7, —OR8, —C(O)R8, —C(O)OR8, —C(O)NR6R7, —SOR9, —SO2R9, —SO2NR6R7, —NR10C(O)R8, —NR10C(O)NR6R7, —NR10SO2R8, —NR10SO2NR6R7, C1-6alkyl, C1-6haloalkyl, C3-10cycloalkyl, and 5- to 10-membered heteroaryl;
R2 is H and R3 is —CF3; or
R2 and R3 are taken together to form oxo;
each R4 is independently selected from halo, —NR6R7, —OR8, —C(O)R8, —C(O)OR8, —C(O)NR6R7, —SOR9, —SO2R9, —SO2NR6R7, —NR10C(O)R8, —NR10C(O)NR6R7, —NR10SO2R8, —NR10SO2NR6R7, C1-6alkyl, C1-6haloalkyl, C3-10cycloalkyl, C6-10aryl, and 5- to 10-membered heteroaryl; or
two R4's are taken together with the carbon atoms to which they are attached and any intervening atoms to form a C3-10cycloalkyl, and any remaining R4's are independently selected from halo, —NR6R7, —OR8, —C(O)R8, —C(O)OR8, —C(O)NR6R7, —SOR9, —SO2R9, —SO2NR6R7, —NR10C(O)R8, —NR10C(O)NR6R7, —NR10SO2R8, —NR10SO2NR6R7, C1-6alkyl, C1-6haloalkyl, C3-10cycloalkyl, C6-10aryl, and 5- to 10-membered heteroaryl;
each R5 is selected from halo, —NR6R7, —OR8, —C(O)R8, —C(O)OR8, —C(O)NR6R7, —SOR9, —SO2R9, —SO2NR6R7, —NR10C(O)R8, —NR10SO2R8, C1-6alkyl, and C1-6haloalkyl;
R6 and R7 are independently selected at each occurrence from H, C1-6alkyl, C1-6haloalkyl, and C3-10cycloalkyl;
each R8 is independently selected from H, C1-6alkyl, C1-6haloalkyl, C3-10cycloalkyl, C6-10aryl, and 5- to 10-membered heteroaryl;
each R9 is independently selected from C1-6alkyl, C1-6haloalkyl, C3-10cycloalkyl, C6-10aryl, and 5- to 10-membered heteroaryl;
each R10 is independently selected from H, C1-6alkyl, C1-6haloalkyl, and C3-10cycloalkyl;
n is 1, 2, 3, or 4;
m is 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10; and
p is 0, 1, 2, or 3.