Patent ID: 11970708
Assignee: ARTICURE INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A split-dual replicating-retrovirus vector system with minimized recombination occurrence, comprising:
1) a first recombinant retroviral expression vector containing a Gag-Pol gene, a sEF1α (short elongation factor 1α) promoter or a first MCMV (murine cytomegalovirus) promoter, and operably linked to a first therapeutic gene, wherein the first MCMV promoter is a minimized promoter consisting of a sequence selected from SEQ ID NO: 4, NO: 5, NO: 6 and NO: 7; and
2) a second recombinant retroviral expression vector containing an Env gene of a virus, and a second MCMV promoter, and operably linked to a second therapeutic gene, wherein the second MCMV promoter is a minimized promoter consisting of a sequence selected from SEQ ID NO: 4, NO: 5, NO: 6 and NO: 7.