Patent ID: 11857813
Assignee: UNIVERSITY OF WASHINGTON
Field: Medical technology (Instruments)
Classification: CPC A | IPC A

Claim 0:
1. A system comprising:
an ultrasound source having a focal region and configured to deliver high intensity focused ultrasound to a target site in a tissue; and
a controller operably coupled to the ultrasound source, wherein the controller causes the ultrasound source to deliver the high intensity focused ultrasound in pulses having a pulse length in a range of about 1 millisecond (ms) to about 10 ms and a duty cycle in a range of about 1% to about 5%, thereby lysing cells in the target site and substantially preserving an extracellular matrix in the target site,
wherein vessels in the tissue are perfused with a decellularization detergent when the high intensity focused ultrasound is delivered to the target site in the tissue.