Patent ID: 11918661
Assignee: PURDUE RESEARCH FOUNDATION
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 8:
9. A method of using a nano-droplet composition as an ultrasound contrast agent, wherein the method comprises:
providing a nano-droplet composition comprising a core and a polymeric shell, wherein the fluorocarbon core and a polymeric shell forms a micelle with a size range of 10-1000 nm, wherein the polymeric shell comprises a biocompatible polymeric material, wherein the biocompatible polymeric material comprises bovine serum albumin, alone or in further combination with a synthetic polymer, a polysaccharide, a protein, a peptide, a lipid, a nucleic acid, or any combination thereof; and wherein the core is substantial in liquid form;
subjecting the nano-droplet composition to a temperature modulation process to modulated or enhance the ultrasound signal exhibited by the nano-droplet composition, wherein the temperature modulation process is applied outside a human, animal or biological cell or tissue for an ultrasound imaging process and can be controlled;
administering the nano-droplet composition that exhibits enhanced ultrasound contrast to the human, animal or biological cell or tissue subject; and
performing an ultrasound imaging on the human, animal or biological cell or tissue.