Patent ID: 11926619
Assignee: EISAI R&D MANAGEMENT CO., LTD
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 5:
6. A compound of Formula III:, or a pharmaceutically acceptable salt thereof,
wherein:
n is chosen from 0, 1 and 2;
m is chosen from 1, 2, and 3;
R1 is chosen from C1-C8 alkyl groups, C3-C8 cycloalkyl groups, —NR11R12 groups,, groups,, groups,, groups,, groups,, groups,, groups,, groups,, groups, and, groups,
R11 is chosen from hydrogen, —NR16R17 groups, C1-C8 alkyl groups, alkyl)-CO2H groups, —(C1-C8 alkyl)-CO2R12 groups, —(C1-C8 alkyl)-NR16R17 groups, C3-C8 cycloalkyl groups, and heterocyclyl groups, wherein the —NR11R12 groups, C1-C8 alkyl groups, C3-C8 cycloalkyl groups and heterocyclyl groups may be unsubstituted or substituted from 1-3 times with a group independently chosen from C1-C6 alkyl groups, —(C1-C6 alkyl)-CO2H groups, hydroxy, halogen groups, and C1-C6 alkoxy groups, and wherein the heterocyclyl group is a 3-, 4-, 5-, 6-, 7-, or 8-membered ring containing at least one heteroatom independently chosen from 0, N, and S or a bicyclic heterocycle;

R12 is chosen from hydrogen and C1-C6 alkyl groups;
one of either R2 or R3 is chosen from hydrogen and C1-C6 alkyl groups, and the other is chosen from hydrogen, —OR10, —OC(O)R10, —OC(O)R1, and C1-C6 alkyl groups;
R4 is hydrogen or hydroxy;
R5 and R6 are each independently chosen from C1-C6 alkyl groups;
R7 and R8 are each independently chosen from hydrogen, hydroxy, C1-C6 alkoxy groups, and C1-C6 alkyl groups; and
R9 and R10 are each independently chosen from hydrogen, C1-C6 alkyl groups, hydroxy, and C1-C6 alkoxy groups; or, one of R9 or R10 is oxo and the other is absent;
Z is chosen from C1-C6 alkyl groups, —C(O)—C1-C6 alkyl groups, —OR13, and —NR14R15 groups,
wherein R13 is chosen from hydrogen, C1-C6 alkyl groups, and —C(O)—C1-C6 alkyl groups,
wherein R14 and R15 are each independently chosen from hydrogen, C1-C6 alkyl groups, and methoxy C1-C6 alkyl groups; or R14 and R15 may be taken together with the N to form a group chosen from, a morpholine, a piperidine, a thiazolidine, an indole, an indoline, and an isoindoline ring;
wherein Z may be unsubstituted or substituted from 1-3 times with a group independently chosen from C1-C6 alkyl groups, C3-C5 cycloalkyl groups, hydroxy C1-C6 alkyl groups, C1-C6 alkoxy groups, methoxy C1-C6 alkyl groups, —NR16R17 groups,, wherein R16 and R17 are each independently chosen from hydrogen and C1-C6 alkyl groups;
wherein if:
R9 and R10 are each independently chosen from hydrogen, hydroxy, and a C1-C6 alkyl group,
Z is a C1-C6 alkyl group,
R2 is OR10 and R10 is hydrogen,
R3 is a C1-C6 alkyl group,
R4 is hydroxy,
R5 and R6 are each a C1-C6 alkyl group, and
one of R7 and R8 is hydrogen and the other is a C1-C6 alkyl group or hydroxy,
then R1 is not a C1-C6 alkyl group.