Patent ID: 11879020
Assignee: BROWN UNIVERSITY
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A method of treating a neurological disorder in a subject afflicted with the neurological disorder comprising administering a composition comprising (a) a therapeutically-effective amount of dR7-2097 and (b) at least one pharmaceutically-acceptable carrier,
wherein the dR7-2097 comprises RRRRRRRC (SEQ ID NO: 2 or PolyArg) in the following dR7-2097 structure:, wherein the PolyArg consists of all the R enantiomer, (R)-Arg or (“R”)-arginine, and all the S enantiomer, (“S”)-cysteine amino acids in the RRRRRRRC (SEQ ID NO: 2);
wherein in dR7-2097 there is a disulfide linkage from the (S)-Cys or (“S”)-cysteine to one (R)-Cys or (“R”)-cysteine;
wherein the PolyArg is operative to transport the dR7-2097 across the blood-brain barrier (BBB) in the subject, and the dR7-2097 is at least four times more efficacious than CN2097 in treating the neurological disorder; and wherein the neurogical disorder is major depressive disorder.