Patent ID: 11866489
Assignee: ACADEMIA SINICA
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A monoclonal anti-signal peptide-complement protein Clr/Cls, Uegf, and Bmp1 (CUB)-epidermal growth factor (EGF) domain-containing protein 2 (SCUBE2) antibody or a binding fragment thereof, comprising an antigen binding region specifically targeting the first cysteine-rich repeat motif, the first cysteine-rich motif ranging from amino acid position 668 to 725 of SCUBE2 (SEQ ID NO: 66), the antigen binding region comprising a heavy chain variable domain (VH) and a light chain variable domain (VL), wherein:
(a) the VH comprises a CDR1 comprising the amino acid sequence of SEQ ID NO: 51, a CDR2 comprising the amino acid sequence of SEQ ID NO: 52, and a CDR3 comprising the amino acid sequence of SEQ ID NO: 53; and
(b) the VL comprises a CDR1 comprising the amino acid sequence of SEQ ID NO: 54, a CDR2 comprising the amino acid sequence of SEQ ID NO: 55, and a CDR3 comprising the amino acid sequence of SEQ ID NO: 56.