Patent ID: 11912763
Assignee: L & L BIOPHARMA CO., LTD.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 19:
20. The bispecific antibody as defined in claim 7, wherein the immunoglobulin comprises a light chain amino acid sequence as shown in SEQ ID NO: 38 and a heavy chain amino acid sequence as shown in SEQ ID NO: 39; wherein
the cytokine or the fragment thereof, or the cytokine receptor or the fragment thereof is TGFβRII, and the sequence of TGFβRII is as shown in SEQ ID NO: 1, and there are two copies of TGFβRII; the two TGFβRIIs are symmetrically linked to the C-terminals of the two heavy chains of the immunoglobulin, and the C-terminal amino acid is mutated from K to A, respectively; or,
the cytokine or the fragment thereof, or the cytokine receptor or the fragment thereof is IL10, and the sequence of IL10 is as shown in SEQ ID NO: 2, and there are two copies of IL10; the two copies of IL10 are symmetrically linked to the C-terminals of the two heavy chains of the immunoglobulin, and the C-terminal amino acid is mutated from K to A, respectively.