Patent ID: 11878005
Assignee: AUSTINPX, LLC
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 0:
1. A method of making a pharmaceutical composition comprising:
(a) providing crystalline deferasirox (DFX) and one or more pharmaceutically acceptable excipients;
(b) compounding the materials of step (a) in a thermokinetic mixer at about 100° C. to 200° C. for 5 to about 300 seconds,
wherein the thermokinetic compounding of DFX and the one or more pharmaceutically acceptable excipients forms a melt blended pharmaceutical composite, and wherein said melt blended composite is an amorphous solid dispersion that comprises about 30%-60% DFX and remains amorphous per x-ray diffraction analysis following storage in an open container at about 40° C., relative humidity of about 75%, at five weeks.