Patent ID: 11945861
Assignee: IMMUNOQURE AG
Field: Measurement (Instruments)
Classification: CPC C  A  G | IPC A  C  G

Claim 8:
9. The cDNA molecule of claim 6, wherein the monoclonal antibody or IFN-α binding fragment thereof is selected from the group consisting of a single chain Fv fragment (scFv), an F(ab′) fragment, an F(ab) fragment, and an F(ab′)2 fragment wherein the antibody or IFN-α binding fragment thereof comprises in its variable regions the complementarity determining regions (CDRs)
VH CDRs: amino acids 31-35 of SEQ ID NO:84 and amino acids 50-66 of SEQ ID NO:84 and amino acids 99-112 of SEQ ID NO:84; and
VL CDRs: amino acids 24-34 of SEQ ID NO:86 and amino acids 50-56 of SEQ ID NO:86 and amino acids 89-98 of SEQ ID NO:86 and
wherein the antibody has the following properties
(i) binds to human IFN-α subtypes IFNα1/13 (IFNα1b), IFNα2, IFNα4, IFNα5, IFNα6, IFNα7, IFNα8, IFNα10, IFNα14, IFNα16, IFNα17 and IFNα21; and
(ii) does not bind to IFN-ω.