Patent ID: 11884655
Assignee: TREVENA, INC.
Field: Organic fine chemistry (Chemistry)
Classification: CPC C | IPC C

Claim 1:
2. The process of claim 1, wherein the process comprises the steps of:
(a) adding a coupling reagent and optionally an additive to a solution of a compound of, , in a first organic solvent to form a mixture and stirring the mixture for at least about 5 minutes;
(b) stifling the mixture of step (a) with a compound of, (c) heating the mixture of step (b) to a temperature of at least about 40° C. and stifling the mixture under the temperature;
(d) cooling the mixture of step (c) and adding water to the mixture to form a slurry;
(e) stifling the slurry of step (d);
(f) filtering the slurry of step (e) to obtain a solid;
(g) washing the solid of the step (f) with water and/or a second organic solvent; and
(h) drying the solid of the step (g) at a temperature of at least about 30° C. under vacuum to form the compound of, Formula (IX), wherein the variables are as defined in claim 1.