Patent ID: 11858927
Assignee: HEPAREGENIX GMBH
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC C

Claim 0:
1. A compound having formula (Ic) or a pharmaceutically acceptable salt, solvate, or optical isomer thereof,, , wherein the variables in formula (Ic) have the meanings as follows:
R1 is H, alkyl or heterocycloalkyl having 4 to 5 ring carbon atoms and 1 or 2 heteroatoms independently selected from 0, NH or N-alkyl;
Rw is —NR10SO2R12 or —N═S(═O)R10NR10R10;
Rx is F;
Ry is F;
R4 is
H,
halogen, or
alkyl;

R5 is a heteroaromatic 5- or 6-membered monocyclic or heteroaromatic 9- or 10-membered bicyclic group having 1, 2 or 3 heteroatoms independently selected from O, N and S which group is optionally substituted with 1 or 2 groups independently selected from alkyl,
haloalkyl,
alkoxy,
—NR10R10,
halogen,
—NR10-cycloalkyl,
tetrazolyl,
—O-alkylene-NR10R10,

—NR10-alkylene-Oalkyl,
—CN,
—CONR10R10,
—COOR10)
alkylSO(═NR10)—,
—CONR10—O-alkylene-OH,
—CONR10—O-alkylene-O-alkyl,
morpholinyl,
piperazinyl,
oxadiazolyl and
phenylcarbonyl;

R6 is H, or alkyl;
R10 at each occurrence independently is H, alkyl, phenyl which is optionally substituted with hydroxyl or alkoxy or is phenylalkyl wherein the phenyl group is optionally substituted with halogen; and
R12 is H, alkyl, phenylalkyl, or —NR10R10.