Patent ID: 11878975
Assignee: BRISTOL-MYERS SQUIBB COMPANY
Field: Organic fine chemistry (Chemistry)
Classification: CPC C | IPC C

Claim 0:
1. A compound of Formula (I), N-oxide, or a salt thereof, wherein:
G is:, (iv) a 9-membered heterocyclic ring selected from:, A is: —CHR12R13, wherein R12 and R13 together with the carbon atom to which they are attached and the hydrogen atom attached to the carbon atom, form a cyclic group selected from azabicyclo[4.1.1]octanyl, azetidinyl, C3-6 cycloalkyl, diazaspiro[4.5]decanonyl, morpholinyl, octahydrocyclopenta[c]pyrrolyl, or quinuclidinyl, each substituted with zero to 3 R12a;
R1 is —CH2CH3 or —CH(CH3)2;
each R2 is independently —CH3 or —OCH3;
R2a is —CH3;
each R2b is independently H or —CH3;
each R12a is independently —OH, —CH3, —CH2CH2CH3, —CH(CH3)2, —CH2CH(CH3)2, —CF3, —CH2CH2CH2CF3, —CH2CN, —CH2C(CH3)2OH, —CH2CH2OCH3, —CH2C(O)NH(CH3), —CH2C(O)N(CH3)2, —CH2C(O)NH2, —CH2CH2S(O)2CH3, —CH2CH2NHS(O)2CH3, —OCH3, —NRxRx, —N(CH3)(CH2CH3), —N(CH3)(CH(CH3)2), —NRx(CH2CHF2)—NH(CH2CF3), —N(CH3)(CH2CH2CF3), —N(CH3)(CH2CH2OCH3), —NH(CH2CN), —N(CH3)CH2N(CH3)2, —NH(CH2C(CH3)2OH), —NH(CH2C(O)NH2), —N(CH3)(OCH3), —NRxCH2CH2S(O)2CH3, —NHC(O)CH3, —NHC(O)CH2CF3, —NHC(O)CHRxNH(CH3), —NRxC(O)CH2N(CH3)2, —NHC(O)CH2N(CH3)(CH2CH3), —NHC(O)CH2N(CH2CH3)2, —NHC(O)CH2NH(CH2C(CH3)2OH), —NHCH2C(O)NRx(CH3), —NHS(O)2CH3, —C(O)C(CH3)3, —C(O)CH(CH2CH3)2, —C(O)CH2OCH3, —C(O)CH2CH2OCH3, —C(O)CH2NH(CH3), —C(O)CH2N(CH3)2, —C(O)CH(CH3)NH(CH3), —C(O)CH2N(CH3)(CH2CH3), —C(O)CH2N(CH2CH3)2, R12b, —CH2R12b, —C(O)R12b, —C(O)CH2R12b, —C(O)CH2NHR12b, —C(O)NRxR12b, —NRxC(O)CH2R12b, —NRxR12b, —NRxCH2R12b, —NHC(O)CH2NRxR12b, —NHC(O)CH2NRxCH2R12b, —NHCH2C(O)NHR12b, or —OR12b;
R12b is azetidinyl, cyclopropyl, diazabicyclo[2.2.1]heptanyl, dioxolanyl, dioxidotetrahydrothiopyranyl, dioxidothiomorpholinyl, imidazolyl, morpholinyl, octahydrocyclopenta[c]pyrrolyl, octahydropyrrolo[3,4-c]pyrrolyl, oxaazaspiro[3.3]heptanyl, oxetanyl, phenyl, piperazinyl, piperazinonyl, piperidinyl, pyridinyl, pyrrolidinyl, quinuclidinyl, tetrahydrofuranyl, tetrahydropyranyl, or triazolyl, each substituted with zero to 4 substituents independently selected from F, —OH, —CH3, —CH(CH3)2, —CH2OH, —OCH3, —CH2CH2OCH3, —NRxRx, and —C(O)NH2;
each Rx is independently H or —CH3;
n is zero; and
p is zero, 1, 2, or 3.