Patent ID: 11884711
Assignee: BEIJING QL BIOPHARMACEUTICAL CO., LTD.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A fusion polypeptide comprising, from N terminus to C terminus, a serum albumin binding single domain antibody, a polypeptide linker and a GDF15:
wherein the single domain antibody comprises a VHH domain, wherein the VHH domain comprises a complementarity determining region 1 (CDR1) comprising the sequence of SEQ ID NO: 1, a CDR2 comprising the sequence of SEQ ID NO: 2, and a CDR3 comprising the sequence of SEQ ID NO: 3; and
wherein the polypeptide linker has a length of 40-80 amino acid residues, wherein the polypeptide linker comprises an amino acid sequence selected from the group consisting of SEQ NOs: 48-49 and 61.