Patent ID: 11865226
Assignee: CORMATRIX CARDIOVASCULAR, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 0:
1. A cardiovascular prosthesis, consisting of:
an Extracellular Matrix (ECM)-mimicking composition consisting of a plurality of particulate structures, each of said plurality of particulate structures consisting of poly(glycerol sebacate) (PGS), cerivastatin and everolimus, said cerivastatin is present in an amount of 0.01 wt. % to 0.1 wt. % of said ECM-mimicking composition, said everolimus is present in an amount of 0.001 wt. % to 0.01 wt. % of said ECM-mimicking composition,
wherein said plurality of particulate structures are adapted to modulate inflammation of damaged cardiovascular tissue in vivo by increasing expression of Kruppel like factor 2 (KLF-2), whereby localized expression of monocyte chemoattractant protein 1 (MCP-1) and C-C chemokine receptor type 2 (CCR2) is inhibited at transcriptional and translational levels as a function of said increased expression of said KLF-2.