Patent ID: 11878055
Assignee: BIONTECH SE
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 8:
9. A composition comprising an RNA molecule having a nucleotide sequence as set forth in SEQ ID NO: 161, wherein the RNA molecule comprises:
(i) N1-methyl-pseudouridine in place of each uridine; and
(ii) a 5′ cap that comprises m27,3′-OGppp(m12′-O)ApG;
wherein the RNA molecule is encapsulated in a lipid nanoparticle (LNP); and
wherein the LNP comprises molar ratios of 20-60% ionizable cationic lipid, 5-25% neutral lipid, 25-55% sterol, and 0.5-15% PEG-modified lipid.