Patent ID: 11890350
Assignee: DEFENCE THERAPEUTICS INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A

Claim 15:
16. A pharmaceutical composition comprising a bile acid-peptide conjugate as a cytotoxic or cytostatic agent, the conjugate being free or releasably bound to a carrier molecule and being present in the pharmaceutical composition at an effective concentration of at least 40 micromolar, wherein the bile acid comprises chenodeoxycholic acid (CDCA) and the peptide comprises an SV40 NLS (SEQ ID NO: 1 or 2), wherein the bile acid-peptide conjugate when releasably bound to the carrier molecule is bound via an enzymatically cleavable linker, a photocleavable linker, a redox-sensitive linker, or a pH-sensitive linker, and wherein the carrier molecule is not a polypeptide antigen.