Patent ID: 11866415
Assignee: THE SCRIPPS RESEARCH INSTITUTE
Field: Organic fine chemistry (Chemistry)
Classification: CPC C | IPC C

Claim 0:
1. A method of forming a beta-lactone of formula (2):, from a carboxylic acid having a beta-carbon with a hydrogen atom disposed thereon, comprising contacting a carboxylic acid of formula (1):, wherein
R1 and R2 are each independently H or alkyl, provided at least one of R1 and R2 is alkyl, wherein the alkyl is unsubstituted or is substituted with halo, oxo, dialkylphosphono, cycloalkyl, alkoxy, aryloxy, benzyloxy, heterocyclyl, aryl, or heteroaryl;

and an effective amount of a palladium(II) catalyst in the presence of an effective amount of an N-protected aminoacid ligand, and t-butylhydroperoxide in a solvent comprising hexafluoroisopropanol (HFIP), at about 60° C., to provide the beta-lactone of formula (2).