Patent ID: 11887734
Assignee: ELUCID BIOIMAGING INC.
Field: Medical technology (Instruments)
Classification: CPC G  A  Y | IPC A  G

Claim 0:
1. A computer-implemented method for clinical decision support, the method comprising:
receiving non-invasively obtained data related to a plaque from a patient;
inputting the non-invasively obtained data from the patient to a neural network;
generating, as an output of the neural network, virtual 'omics data that include predicted pathway activation or molecule levels, or both, of the patient by applying the neural network to the non-invasively obtained data from the patient;
updating an in silico systems biology model using the generated virtual 'omics data to generate an in silico patient-specific systems biology model, wherein
(i) the in silico systems biology model comprises a set of networks, wherein each network comprises a plurality of nodes, each node representing a baseline level of a molecule, and a plurality of edges between pairs of nodes, each edge representing a molecule-molecule interaction,
(ii) at least two of the nodes represent molecules whose levels are affected by atherosclerotic cardiovascular disease, and
(iii) at least one of the set of networks includes a disease-associated pathway activation or molecule level, or both, for each of the nodes in the network;

perturbing the in silico patient-specific systems biology model to simulate a therapeutic effect of a lipid-lowering agent for the patient; and
providing an output indicating a level of improvement in the atherosclerotic cardiovascular disease by the lipid-lowering agent for the patient and a recommendation supporting a clinical decision as to whether the lipid-lowering agent would benefit the patient.