Patent ID: 11866730
Assignee: SEASTAR MEDICAL, INC.
Field: Chemical engineering (Chemistry)
Classification: CPC B  A  C | IPC A  B  C

Claim 4:
5. A method for treating a subject having or at risk of developing an inflammatory condition, the method comprising:
(a) providing a cartridge comprising
(i) a rigid housing defining an inner volume (IV), a fluid inlet port and a fluid outlet port, wherein the inner volume is in fluid flow communication with the fluid inlet port and the fluid outlet port; and
(ii) a solid support disposed within the housing and defining a fluid contacting surface with a surface area (SA) capable of sequestering an activated leukocyte, if present in a body fluid entering the housing via the fluid inlet port, wherein the cartridge has an SA/IV ratio ranging from greater than 150 cm−1 to 800 cm−1; and

(b) introducing a body fluid from a subject into the housing via the fluid inlet port under conditions that permit sequestration of an activated leukocyte and/or an activated platelet on the fluid contacting surface of the solid support; and
(c) treating the leukocyte and/or platelet sequestered in step (b) to reduce the risk of developing inflammation associated with the inflammatory condition or to alleviate inflammation associated with the inflammatory condition.