Patent ID: 11904118
Assignee: MICELL MEDTECH INC.
Field: Medical technology (Instruments)
Classification: CPC A | IPC A

Claim 0:
1. A method comprising the steps of
providing a device comprising a balloon; and a coating on at least a portion of the balloon, wherein the coating comprises an active agent, a polymer and a cationic binding agent, wherein the active agent includes a plurality of macrolide immunosuppressive drug particles in crystalline form, some of the particles having a portion uncovered by the polymer and some of the particles being fully encapsulated in the polymer;
inflating the balloon of the device in vivo; and
transferring at least 3% of the active agent and at least a portion of the polymer to a treatment site upon expansion of the balloon in vivo,
wherein the binding agent comprises at least one of: Polyarginine, Polyarginine 9-L-pArg, DEAE-Dextran (Diethylaminoethyl cellulose-Dextran), DMAB (Didodecyldimethylammonium bromide), PEl (Polyethyleneimine), TAB (Tetradodecylammonium bromide), and DMTAB (Dimethylditetradecylammonium bromide).