Patent ID: 11964941
Assignee: CITY OF HOPE
Field: Organic fine chemistry (Chemistry)
Classification: CPC C | IPC A  C

Claim 2:
3. A method of treating acute myeloid leukemia expressing a FLT3-kinase in a subject in need thereof, said method comprising administering an effective amount of a compound, having formula, wherein
R50 is hydrogen, oxo, halogen, —CF3, —CN, —OH, —NH2, —COOH, —CH2COOH, CONH2, NO2, —SH, —OCF3, —OCF2, or unsubstituted alkyl;
R51 is hydrogen, oxo, halogen, —CF3, —CN, —OH, —NR51AR51B, —COOH, CH2COOH, —CONH2, —NO2, —SH, —OCF3, —OCHF2, unsubstituted alkyl, or unsubstituted heteroalkyl;
R51A and R51B are independently hydrogen or unsubstituted alkyl;
R52 is halogen, —CF3, —CN, —OH, —NH2, —COOH, —CONH2, or unsubstituted alkyl; and
z1 and z2 are independently 0, 1, 2, 3, 4, or 5,, including pharmaceutically acceptable salts thereof; and, thereby treating said acute myeloid leukemia.