Patent ID: 11964941
Assignee: CITY OF HOPE
Field: Organic fine chemistry (Chemistry)
Classification: CPC C | IPC A  C

Claim 11:
12. A method of modulating activity of a FLT3-kinase, said method comprising contacting a FLT3-kinase with a compound, having formula, wherein
R50 is hydrogen, oxo, halogen, —CF2, —CN, —OH, —NH2, —COOH, —CH2COOH, —CONH2, —NO2, —SR, —OCF3, —OCHF2, or unsubstituted alkyl;
R51 is hydrogen, oxo, halogen, —CF3, —CN, —OH, —NR51AR51B, —COOH, —CH2COOH, —CONH2, —NO2, —SH, —OCF3, —OCHF2, unsubstituted alkyl, or unsubstituted heteroalkyl;
R51A and R51B are independently hydrogen or unsubstituted alkyl;
R52 is halogen, —CF3, —CN, —OH, —NH2, —COOH, —CONH2, or unsubstituted alkyl;, and
z1 and z2 are independently 0, 1, 2, 3, 4, or 5,, including pharmaceutically acceptable salts thereof; and, thereby modulating said activity of said FLT3-kinase.