Patent ID: 11931480
Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 0:
1. A method of delivering a microgel system to a subject, the method comprising:
(a) delivering to the subject a plurality of microgel particles, wherein at least one microgel particle of the microgel particles comprises
(i) a core comprising one or more hydrogel polymer components; and
(ii) one or more annealing components in a presence of an annealing agent, wherein the one or more annealing components comprises a vinyl unsaturated double bond, a K-peptide, a Q-peptide, or any combination thereof; and

(b) exposing the plurality of microgel particles to the annealing agent, thereby coupling adjacent microgel particles of the plurality of microgel particles together, to form a covalently-stabilized scaffold of microgel particles comprising pores between the adjacent microgel particles, wherein the pores are on the 10 micrometer scale and are substantially devoid of the hydrogel polymer.