Patent ID: 11896671
Assignee: ASCENDIS PHARMA A/S
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A

Claim 0:
1. A compound of formula (I)

D-(L1-L2-A)a  (I),

wherein
-D is drug moiety;
each -L1- is independently a reversible prodrug linker, which is covalently conjugated to -D through a reversible linkage that is cleavable in the absence of enzymes in aqueous buffer at pH 7.4 and 37° C.;
each -L2- is independently a chemical bond or a spacer;
each -A is —X0 or —Y0;
a is selected from the group consisting of 1, 2, 3, 4, 5, 6, 7 and 8;
—X0 is a substituted acyl borate; and
—Y0 is a substituted hydroxylamine.