Patent ID: 11878046
Assignee: OHIO STATE INNOVATION FOUNDATION
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 0:
1. A bicyclic peptide comprising a first cyclic peptide and a second cyclic peptide, the bicyclic peptide having one of the following structures:, or a pharmaceutically acceptable salt thereof,
wherein:
the first cyclic peptide comprises AA1, AA2, AA3, AA4, AA5, AA6, AA7, AA8, and AA9, each independently an amino acid, wherein at least two amino acids are arginine and at least two amino acids independently comprise a hydrophobic side chain;
each m, n, p, and q is independently selected from 0 and 1;
each d is independently 1 or 2;
the second cyclic peptide comprises a peptidyl ligand (Xn);
R1 is OH, OR2, NHR2; and
R2 is alkyl, aryl, heteroaryl, amino acid, peptide sequence of 2 to 20 amino acids, detectable moiety, or solid support.