Patent ID: 11918695
Assignee: YALE UNIVERSITY
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 0:
1. A formulation for application to tissue, comprising particles comprising
(i) a hydrophobic core,
(ii) a shell, coating or corona comprising a hyperbranched polyglycerol not crosslinked with itself post-formation, wherein the hyperbranched polyglycerol is functionalized with an effective amount of one or more reactive functional groups exposed on the surface of the particles to adhere the particles to the tissue,
wherein the hyperbranched polyglycerol is covalently bound to the hydrophobic core or polymers forming the core,
wherein the one or more reactive functional groups are selected from the group consisting of aldehydes, amines, oximes, and O-substituted oximes, and
(iii) one or more agents for application to the tissue, wherein the one or more agents are Janus kinase (JAK) inhibitors and/or signal transducer and activator of transcription (STAT) inhibitors,
wherein the particles adhere to the tissue and/or release an effective amount of the one or more agents into the tissue for at least one day.