Patent ID: 11955209
Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
Field: Medical technology (Instruments)
Classification: CPC G | IPC G

Claim 0:
1. A method comprising:
assigning, by a computing device, each of a plurality of entities to one of a plurality of treatment groups, resulting in groups of entities, wherein the plurality of entities are participants in a clinical trial; and
for each of the plurality of treatment groups:
for each of the entities in a group of the plurality of treatment groups, determining, by the computing device, environmental features of an entity in real time during the clinical trial utilizing a deep learning environmental model outputting classified aspects of the entity's environment;
for each of the entities in the group of the plurality of treatment groups, obtaining, by the computing device, physiological measurements of the entity directly from a monitoring device of the entity during the clinical trial;
for each of the entities in the group of the plurality of treatment groups, determining, by the computing device, an indication of how the entity is feeling in response to an active signal applied to the entity by analyzing digital images of the entity using a convoluted neural network;
for each of the entities in the group of the plurality of treatment groups, determining, by the computing device, variables associated with the clinical trial;
for each of the entities in the group of the plurality of treatment groups, encoding, by the computing device, determined information about the entity during the clinical trial including the classified aspects of the entity's environment, the physiological measurements of the entity, the indication of how the entity is feeling, and the determined variables associated with the clinical trial, into a computer data structure as chromosomes using a genetic algorithm;
for each of the entities in the group of the plurality of treatment groups, iteratively updating, by the computing device, the chromosomes based on new determined information about the entity obtained during the clinical trial;
automatically determining, by the computing device, one or more outlier chromosomes of the chromosomes;
automatically removing, by the computing device, one or more outlier entities in the group of the plurality of treatment groups based on the determined outlier chromosomes;
determining a ranking, by the computing device, of each of the entities in the group of the plurality of treatment groups based on a magnitude of values of the chromosomes corresponding to each entity in the group, wherein the ranking indicates how each entity in the group responds to a therapy in the clinical trial;

for each group in the plurality of treatment groups, crossing over, by the computing device, portions of the encoded information of pairs of entities occupying adjacent positions in the ranking that describe aspects of the clinical trial to create new trial variables regarding aspects of the clinical trial, including dosage amounts of a medication;
sending, by the computing device, the new trial variables to a user; and
measuring, by the computing device, fitness of each of the entities in the group of the plurality of treatment groups based on their respective chromosomes.