Patent ID: 11939636
Assignee: GUARDANT HEALTH, INC.
Field: Biotechnology (Chemistry)
Classification: CPC C | IPC C

Claim 3:
4. The method of claim 1, wherein the analyzing comprises:
i. mapping the set of sequencing reads to a reference sequence;
ii. determining a plurality of epigenetic rates for the plurality of genomic regions of the first sample;
iii. determining a likelihood of a tumor fraction for one or more of the plurality of genomic regions in the second sample based on a predetermined set of epigenetic rates of the plurality of genomic regions of the second sample, a set of epigenetic characteristics for a set of cell-free polynucleotides in the second sample mapped to the plurality of genomic regions, and the epigenetic rates of the plurality of genomic regions of the first sample;
iv. combining the plurality of likelihoods for the one or more of the plurality of genomic regions to determine an overall posterior probability for the presence of the cancer in the subject; and
v. comparing the overall posterior probability for the presence of the cancer in the subject with a predetermined threshold to detect the presence or absence of the cancer.