Patent ID: 11965892
Assignee: BIONTECH US INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC G  A  C | IPC A  C  G

Claim 2:
3. The method of claim 1, wherein the plurality of parameters are based on mono-allelic training data from a set of training cells, each training cell of the set of training cells expressing a recombinant affinity acceptor peptide tagged MHC protein, the mono-allelic training data comprising:
(1) a plurality of training peptide sequences and a plurality of MHC proteins, wherein each training peptide sequence of the plurality is associated with an identity of an MHC protein of the plurality, wherein the identity of each MHC protein of the plurality is based on an identity of the MHC protein of an immunoprecipitate from a training cell of the set of training cells, wherein the immunoprecipitate comprises an anti-affinity acceptor peptide agent that binds to the affinity acceptor peptide and a recombinant affinity acceptor peptide sequence tagged MHC protein with an affinity acceptor peptide sequence that binds to the anti-affinity acceptor peptide agent, and
(2) an observation by mass spectrometry that one or more of the training peptide sequences of the plurality was presented by the recombinant affinity acceptor peptide tagged MHC protein of the immunoprecipitated.