Patent ID: 11911536
Assignee: SOUTHEAST UNIVERSITY
Field: Other special machines (Mechanical engineering)
Classification: CPC A  B | IPC A  B

Claim 0:
1. A method for molding a self-supporting silk fibroin catheter stent, comprising: preparing the self-supporting silk fibroin catheter stent by a mold casting and freeze-drying molding process using silk fibroin as a raw material, wherein the specific preparation steps are as follows:
a. design of mold structure, wherein the mold has a structure including a sleeve, an inner core and caps, in which the sleeve is a polyethylene straw having a diameter of 4-6 mm, by which adhesion of a silk fibroin solution is effectively prevented; the inner core is a fiber rod FRP with a diameter of 2-3 mm; and the caps are made of stainless steel, the cap at one end is closed and the cap at the other end is open, and the diameter is consistent with the diameter of the sleeve; and the overall shape and size of the mold are designed according to requirements;
b. preparation of casting solution, wherein natural mulberry silk is firstly degummed by treatment with a sodium carbonate solution, then dissolved in a ternary solution of CaCl2-EtOH—H2O, dialyzed, and concentrated, for later use; and
c. freeze-drying molding, wherein the solution is casted, and then frozen for 6-24 hrs in a freezer at −20° C.; the freeze dryer is started and set at −40° C. to −35° C. in advance; the mold casted with the solution is positioned on a pre-cooled plate; and the stent is freeze dried according to a predetermined freeze-drying procedure.