Patent ID: 11866468
Assignee: nan
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A mutant angiopoietin-like protein 4 (Angptl4) polypeptide having decreased LPL inhibitory activity, increased resistance to cleavage, or a combination of the foregoing, wherein the mutant Angptl4 polypeptide has at least 95% sequence identity with SEQ ID NO: 9 or SEQ ID NO: 10 and wherein positions 39 and 40 of SEQ ID NO: 9 or SEQ ID NO: 10 are selected from the group consisting of: DK, DA, KE and AE, positions 76 and 80 of SEQ ID NO: 9 or SEQ ID NO: 10 are selected from the group consisting of: C, S, and A, and positions 161-164 of SEQ ID NO: 9 or SEQ ID NO: 10 are selected from the group consisting of: GAAG (SEQ ID NO: 29), AAVV (SEQ ID NO: 69), GVVA (SEQ ID NO: 49), SGGG (SEQ ID NO: 87), and VAVA (SEQ ID NO: 90).