Patent ID: 11869186
Assignee: ELUCID BIOIMAGING INC.
Field: Medical technology (Instruments)
Classification: CPC A  G | IPC A  G

Claim 22:
23. A method of screening a potential subject for enrollment in a clinical trial testing safety or efficacy, or both, of a candidate combination therapy of any two or more of a lipid-lowering therapy, an anti-inflammatory therapy, and an anti-diabetic therapy for a patient diagnosed with atherosclerotic cardiovascular disease, the method comprising:
receiving non-invasively obtained data related to a plaque from the potential subject;
accessing a systems biology model of atherosclerotic cardiovascular disease;
updating the systems biology model using personalized molecule levels derived from the non-invasively obtained data from the potential subject to generate a subject-specific systems biology model;
updating the subject-specific systems biology model with predicted molecular levels derived from information relating to an effect on low density lipoprotein (LDL) levels by a lipid lowering agent, inflammation levels by an anti-inflammatory agent, and glucose levels by an anti-diabetic agent based on known mechanisms of action of each of the agents;
simulating a therapeutic response by the potential subject to a combination of any two or more of the lipid lowering agent, the anti-inflammatory agent, and the anti-diabetic agent in the updated patient-specific systems biology model to obtain simulated therapeutic effects for two or more combinations;
comparing the updated subject-specific systems biology model with and without the simulated therapeutic effects for each of the two or more combinations; and
providing a report indicating whether the potential subject's atherosclerotic cardiovascular disease would likely be improved or unaffected by the combination of any two or more of the lipid lowering agent, the anti-inflammatory agent, and the anti-diabetic agent for the patient, and/or whether the potential subject would suffer an adverse effect from any of combinations of two or more of the lipid lowering agent, the anti-inflammatory agent, and the anti-diabetic agent.