Patent ID: 11903923
Assignee: nan
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 0:
1. A method of prevention and treatment of a disease, comprising administration of a therapeutically effective amount of an andrographolide derivative, wherein the andrographolide derivative has a structure of formula (AL-1):, wherein, the disease is ulcerative colitis or Crohn's disease, and
wherein, for the prevention and treatment of the disease, the andrographolide derivative has functions of reduction of concentration of MPO in colon tissue, suppression of expression of inflammatory cell cytokines TNF-α, IL-6 and IL-1β, suppression of expression of COX-2 and nuclear transcription factor NF-κB, stimulation of expression of PPAR-γ, and prevention of transcription and expression of inflammation-related genes.