Patent ID: 11969474
Assignee: WYETH LLC
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 0:
1. A multivalent immunogenic pneumococcal conjugate composition comprising
polysaccharide-protein conjugates comprising individual Streptococcus pneumoniae capsular polysaccharide serotypes 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F, and 23F covalently linked to CRM197, wherein said serotype 19A polysaccharide is co-lyophilized with said CRM197, wherein said composition comprises less than about 25% free serotype 19A polysaccharide compared to the total amount of serotype 19A polysaccharide, and wherein between 60% and 74% of said conjugates comprising serotype 19A have a Kd below or equal to 0.3 in a CL-4B column;
an aluminum phosphate adjuvant; and
a physiologically acceptable vehicle.