Patent ID: 11958900
Assignee: SIWA CORPORATION
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A method of treating a neurodegenerative disorder, comprising killing or inducing apoptosis in senescent glial cells by administering to a patient in need thereof, a composition comprising an advanced glycation end-product (AGE) antibody,
wherein the AGE antibody is cytotoxic,
the AGE antibody binds a carboxymethyllysine-modified protein,
the neurodegenerative disorder is Alzheimer's disease (AD) or Parkinson's disease (PD),
the AGE antibody comprises
a heavy chain, and
a light chain,
the heavy chain comprises a sequence selected from the group consisting of SEQ ID NO: 29, SEQ ID NO: 31, and SEQ ID NO: 33, and
the light chain comprises a sequence selected from the group consisting of SEQ ID NO: 35, SEQ ID NO: 37, and SEQ ID NO: 39.