Patent ID: 11965019
Assignee: ZYMEWORKS BC INC.
Field: Biotechnology (Chemistry)
Classification: CPC A  C | IPC C

Claim 5:
6. The antibody construct according to claim 5, further comprising a second heterodimer, said second heterodimer comprising:
i) a second immunoglobulin heavy chain polypeptide construct (H2) comprising a heavy chain constant domain 1 (CH1) sequence, and a heavy chain variable domain (VH) sequence, and
ii) a second immunoglobulin light chain polypeptide construct (L2) comprising a light chain constant domain (CL) sequence and a light chain variable domain (VL) sequence,
wherein H2 and L2 form a second Fab region that binds to a second epitope, and at least one of H2 and L2 is linked with or without linkers to the scaffold.