Patent ID: 11932676
Assignee: KLOTHO THERAPEUTICS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 12:
13. The method of claim 1, wherein the recombinant fusion protein further comprises the linker A method of treating and/or preventing acute kidney injury or chronic kidney disease in a mammalian subject, the method comprising:
administering to the mammalian subject a pharmaceutical composition comprising:
a pharmaceutically acceptable carrier or excipient; and
an effective amount of a recombinant fusion protein comprising:
a Klotho protein sequence having at least 99% amino acid sequence identity to SEQ ID NO: 109; and
an immunoglobulin Fc domain having at least 99% amino acid sequence identity to SEQ ID NO: 74; and

a linker disposed between the Klotho protein sequence and the immunoglobulin Fc domain, the linker having at least 88% amino acid sequence identity to SEQ ID NO: 73.