Patent ID: 11865178
Assignee: NORTH CAROLINA STATE UNIVERSITY
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 0:
1. A photo-responsive dermal applicator for use in photoimmunotherapy, the dermal applicator comprising:
a transdermal microneedle array comprising a plurality of microneedles, each microneedle comprising a base portion and a tip portion, wherein the tip portion is distal to the base portion;
an immunogenic composition comprising at least one tumor antigen;
an immunostimulant; and
a photo-sensitive biological pigment comprising melanin;
wherein the immunogenic composition, the immunostimulant, and the photo-sensitive biological pigment are encapsulated within the transdermal microneedle array using a polymeric matrix comprising hyaluronic acid, wherein the immunogenic composition and the photo-sensitive biological pigment are encapsulated within the base portion of the plurality of microneedles, and wherein the immunostimulant is encapsulated within the tip portion of the plurality of microneedles.