Patent ID: 11965039
Assignee: ZP SPV 3 K/S
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 27:
28. A compstatin analogue according to claim 1 which is:, (SEQ ID NO: 278)

Ac-IC(1)IWQDWGEHRC(1)TEG-K([15-carboxy-pentadecanoyl][γGlu])-NH2,

(Compound 92)

 

(SEQ ID NO: 279)

Ac-IC(1)IWQDWGEHRC(1)TEG-K([15-carboxy-pentadecanoyl][γGlu][Peg3][Peg3])-NH2,

(Compound 93)

 

(SEQ ID NO: 283)

Ac-IC(1)IWQDWGEHRC(1)TEGE-K([15-carboxy-pentadecanoyl][γGlu][Peg3][Peg3])-NH2,

(Compound 94)

 

(SEQ ID NO: 280)

Ac-IC(1)IWQDWGEHRC(1)TEG-K((15-carboxy-pentadecanoyl)-

[(Piperazine-1-yl)-acetyl][Peg3][Peg3])-NH2,

(Compound 95)

 

(SEQ ID NO: 281)

Ac-IC(1)IWQDWGEHRC(1)TEG-K([17-carboxy-heptadecanoyl][γGlu][Peg3][Peg3])-NH2,

(Compound 96)

 

(SEQ ID NO: 284)

Ac-IC(1)IWQDWGEHRC(1)TEGE-K([17-carboxy-heptadecanoyl][γGlu][Peg3][Peg3])-NH2,

(Compound 97)

 

(SEQ ID NO: 282)

Ac-IC(1)IWQDWGEHRC(1)TEG-K([19-carboxy-nonadecanoyl][γGlu][Peg3][Peg3])-NH2,

(Compound 98)

 

(SEQ ID NO: 318)

[15-Carboxy-pentadecanoyl]-ESSAIC(1)IWQDWGEHRC(1)TEGE-NH2,

(Compound 99)

 

(SEQ ID NO: 268)

Ac-[K([15-carboxy-pentadecanoyl]-[γGlu][Peg3][Peg3])]GSAIC(1)IWQDWGEHRC(1)TEGE-NH2,

(Compound 100)

 

(SEQ ID NO: 271)

Ac-EGSAIC(1)IWQDWGEHRC(1)TEG-K([15-carboxy-pentadecanoyl][γGlu])-NH2,

(Compound 101)

 

(SEQ ID NO: 277)

Ac-FC(1)I[1-Me-Trp]QDWGEHRC(1)TGAES-K([15-carboxy-

pentadecanoyl][γGlu][Peg3][Peg3])-NH2,

(Compound 102)

 

(SEQ ID NO: 272)

Ac-EGSAYC(1)I[1-Me-Trp]QDWGEH-K([15-carboxy-pentadecanoyl]

[γGlu][Peg3][Peg3])-C(1)[Sar]E-NH2,

(Compound 103)

 

(SEQ ID NO: 273)

Ac-EGSAYC(1)I[1-Me-Trp]QDWGEHRC(1)[Sar]EG-K([15-carboxy-

pentadecanoyl][γGlu][Peg3][Peg3])-NH2,

(Compound 104)

 

(SEQ ID NO: 285)

Ac-SAYC(1)I[1-Me-Trp]QDWGEHRC(1)[Sar]E-K([17-carboxy-

heptadecanoyl][γGlu]KG[γGlu])-NH2,

(Compound 105)

 

(SEQ ID NO: 286)

Ac-SAYC(1)I[1-Me-Trp]QDWGEHRC(1)[Sar]E-K([17-carboxy-

heptadecanoyl][γGlu]G[γGlu])-NH2,

(Compound 106)

 

(SEQ ID NO: 316)

[15-Carboxy-pentadecanoyl]-EGSEYC(1)I[1-Me-Trp]QDWGEHRC(1)[Sar]E-NH2,

(Compound 107)

 

(SEQ ID NO: 317)

[17-Carboxy-heptadecanoyl]-EGSEYC(1)I[1-Me-Trp]QDWGEHRC(1)[Sar]E-NH2,

(Compound 108)

 

(SEQ ID NO: 274)

Ac-EGSAYC(1)I[1-Me-Trp]QDWGEHRC(1)[Sar]EGE-K([17-carboxy-

heptadecanoyl]-[γGlu]G[γGlu])-NH2,

(Compound 109)

 

(SEQ ID NO: 275)

Ac-EGSAYC(1)I[1-Me-Trp]QDWGEHRC(1)[Sar]EGK-K([17-carboxy-

heptadecanoyl][γGlu]G[γGlu])-NH2,

(Compound 110)

 

(SEQ ID NO: 276)

Ac-EGSAYC(1)I[1-Me-Trp]QDWGEHRC(1)[Sar]EK[γGlu]-K([17-

carboxy-heptadecanoyl][γGlu][Peg3][Peg3])]-NH2,

(Compound 111)

 

(SEQ ID NO: 307)

Ac-SEYC(1)I[1-Me-Trp]QDWGEHRC(1)[Sar]EGA-K([17-carboxy-

heptadecanoyl][γGlu]-G[γGlu])]-NH2,

(Compound 112)

 

(SEQ ID NO: 269)

Ac-ASGEYC(1)I[1-Me-Trp]QDWGEHRC(1)[Sar]EGE-K([17-carboxy-

heptadecanoyl][γGlu)-G[γGlu])-NH2,

(Compound 113)

 

(SEQ ID NO: 310)

Ac-SEYC(1)I[1-Me-Trp]QDWGEHRC(1)[Sar]EGE-K([17-carboxy-

heptadecanoyl][γGlu]-G[γGlu])-NH2,

(Compound 114)

 

(SEQ ID NO: 311)

Ac-SEYC(1)I[1-Me-Trp]QDWGEHRC(1)[Sar]EGK-K([17-carboxy-

heptadecanoyl][γGlu]-G[γGlu])-NH2,

(Compound 115)

 

(SEQ ID NO: 312)

Ac-SEYC(1)I[1-Me-Trp]QDWGEHRC(1)[Sar]EGE-K([17-carboxy-

heptadecanoyl][γGlu]-K[γGlu])-NH2,

(Compound 116)

 

(SEQ ID NO: 308)

Ac-SEYC(1)1[1-Me-Trp]QDWGEHRC(1)[Sar]EGE[Peg3][Peg3]-

K([17-carboxy-heptadecanoyl][γGlu]G[γGlu])-NH2,

(Compound 117)

 

(SEQ ID NO: 308)

Ac-SEYC(1)I[1-Me-Trp]QDWGEHRC(1)[Sar]EGA-K([17-carboxy-

heptadecanoyl][γGlu]-G[Peg3][γGlu][Peg3])-NH2,

(Compound 118)

 

(SEQ ID NO: 287)

Ac-SEFC(1)I[1-Me-Trp]QDWGEHRC(1)[Sar]EGA-K([17-carboxy-

heptadecanoyl][γGlu]-G[Peg3][γGlu][Peg3])-NH2,

(Compound 119)

 

(SEQ ID NO: 305)

Ac-SEFC(1)I[1-Me-Trp]QEWGEHRC(1)[Sar]EGA-K([17-carboxy-

heptadecanoyl][γGlu]-G[Peg3][γGlu][Peg3])-NH2,

(Compound 120)

 

(SEQ ID NO: 313)

Ac-SEYC(1)I[1-Me-Trp]QEW[Sar]EHRC(1)[Sar]EK[γGlu]A-K([17-carboxy-

heptadecanoyl][γGlu]G[Peg3][γGlu]-[Peg3])-NH2,

(Compound 121)

 

(SEQ ID NO: 314)

Ac-SEYC(1)I[1-Me-Trp]QEWGEHRC(1)[Sar]EGA-K([17-carboxy-

heptadecanoyl][γGlu]-G-[Peg3][γGlu][Peg3])-NH2,

(Compound 122)

 

(SEQ ID NO: 288)

Ac-SEFC(1)I[1-Me-Trp]QDWGEHRC(1)[Sar]EGE[Peg3][Peg3]-

K([17-carboxy-heptadecanoyl][γGlu]G[γGlu])-NH2,

(Compound 123)

 

(SEQ ID NO: 306)

Ac-SEFC(1)I[1-Me-Trp]QEWGEHRC(1)[Sar]EGE[Peg3][Peg3]-K([17-carboxy-

heptadecanoyl][γGlu]G[γGlu])-NH2,

(Compound 124)

 

(SEQ ID NO: 315)

Ac-SEYC(1)I[1-Me-Trp]QEWGEHRC(1)[Sar]EGE[Peg3][Peg3]-

K([17-carboxy-heptadecanoyl][γGlu]G[γGlu])-NH2,

(Compound 125)

 

(SEQ ID NO: 302)

Ac-SEFC(1)I[1-Me-Trp]QDWGEHRC(1)TEGE[Peg3][Peg3]-K([17-carboxy-

heptadecanoyl][γGlu]G[γGlu])-NH2,

(Compound 126)

 

(SEQ ID NO: 292)

Ac-SEFC(1)I[1-Me-Trp]QDWGEHRC(1)[Sar]EGE[Peg3][Peg3]-[K[(15-carboxy-

pentadecanoyl)[γGlu]G[γGlu]])-NH2,

(Compound 127)

 

(SEQ ID NO: 293)

Ac-SEFC(1)I[1-Me-Trp]QDWGEHRC(1)[Sar]EGE[Peg3][Peg3]-

[K[(19-carboxy-nonadecanoyl)[γGlu]G[γGlu])-NH2,

(Compound 128)

 

(SEQ ID NO: 289)

Ac-SEFC(1)I[1-Me-Trp]QDWGEHRC(1)[Sar]EGEGGG-K([17-carboxy-

heptadecanoyl]-[γGlu]G[γGlu])-NH2,

(Compound 129)

 

(SEQ ID NO: 299)

Ac-SEFC(1)I[1-Me-Trp]QDWGEHRC(1)TEGEGGG-K([17-carboxy-

heptadecanoyl]-[γGlu]G[γGlu])-NH2,

(Compound 130)

 

(SEQ ID NO: 300)

Ac-SEFC(1)I[1-Me-Trp]QDWGEHRC(1)TEGEGGG-K([15-carboxy-

pentadecanoyl]-[γGlu]G[γGlu])-NH2,

(Compound 131)

 

(SEQ ID NO: 296)

Ac-SEFC(1)I[1-Me-Trp]QDWGEHRC(1)[Sar]EK[γGlu]GGG-K([17-

carboxy-heptadecanoyl][γGlu]G[γGlu])-NH2,

(Compound 132)

 

(SEQ ID NO: 303)

Ac-SEFC(1)I[1-Me-Trp]QDWGEHRC(1)TEK[γGlu]GGG-K([17-carboxy-

heptadecanoyl]-[γGlu]G[γGlu])-NH2,

(Compound 133)

 

(SEQ ID NO: 270)

Ac-EFC(1)1[1-Me-Trp]QDWGEHRC(1)EGE-K([17-carboxy-heptadecanoyl]

[γGlu]G[γGlu])-NH2,

(Compound 134)

 

(SEQ ID NO: 304)

Ac-SEFC(1)I[1-Me-Trp]QDWGEHRC(1)TGAES-K([15-carboxy-hexadecanoyl]

[γGlu]G[γGlu])-NH2,

(Compound 135)

 

(SEQ ID NO: 297)

Ac-SEFC(1)I[1-Me-Trp]QDWGEHRC(1)TEGE[8-aminooctanoyl]-K([17-carboxy-

heptadecanoyl][γGlu]G[γGlu])-NH2,

(Compound 136)

 

(SEQ ID NO: 298)

Ac-SEFC(1)I[1-Me-Trp]QDWGEHRC(1)TEGE[8-aminooctanoyl]E-K([17-carboxy-

heptadecanoyl][γGlu]G[γGlu])-NH2,

(Compound 137)

 

(SEQ ID NO: 290)

Ac-SEFC(1)I[1-Me-Trp]QDWGEHRC(1)[Sar]EGE[Peg3]-K([17-carboxy-

heptadecanoyl][γGlu]-G[γGlu])-NH2,

(Compound 138)

 

(SEQ ID NO: 294)

Ac-SEFC(1)I[1-Me-Trp]QDWGEHRC(1)[Sar]EGESES-K([17-carboxy-

heptadecanoyl]-[γGlu]G[γGlu])-NH2,

(Compound 139)

 

(SEQ ID NO: 291)

Ac-SEFC(1)I[1-Me-Trp]QDWGEHRC(1)[Sar]EGE[Peg3]ES-K([17-carboxy-

heptadecanoyl][γGlu]G[γGlu])-NH2,

(Compound 140)

 

(SEQ ID NO: 295)

Ac-SEFC(1)I[1-Me-Trp]QDWGEHRC(1)[Sar]EGESES-K([17-carboxy-

heptadecanoyl][γGlu])-NH2,

(Compound 141)

 

(SEQ ID NO: 301)

Ac-SEFC(1)I[1-Me-Trp]QDWGEHRC(1)TEGE[Peg3]ES-K([17-carboxy-

heptadecanoyl][γGlu])-NH2,

(Compound 142)

 

(SEQ ID NO: 319)

Ac-SEFC(1)I[1-Me-Trp]QDWGEHR[C(1)[Sar]EGE[Peg3][Peg3][Peg3]-

K([17-carboxy-heptadecanoyl][γGlu]G[γGlu])-NH2,

(Compound 143)

 

(SEQ ID NO: 320)

Ac-SEFC(1)I[1-Me-Trp]QDW[Sar]EHRC(1)[Sar]E[Peg3][Peg3]-

K([17-carboxy-heptadecanoyl][γGlu]G[γGlu])-NH2, or

(Compound 144)

 

(SEQ ID NO: 321)

Ac-EF[C(1)I[1-Me-Trp]QDWGEHRC(1)[Sar]EA[Peg3][Peg3]-

K([17-carboxy-heptadecanoyl][γGlu]G[γGlu])-NH2.

(Compound 145)