Patent ID: 11944689
Assignee: SEAGEN INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 10:
11. The Ligand Drug Conjugate compound of claim 10, wherein the compound is represented by the structure of:, in pharmaceutically acceptable salt form(s), wherein
R′ is hydrogen or —NO2; and
R45 is —CH2OH or —CO2H,, or
the compound is represented by the structure of:, in pharmaceutically acceptable salt form(s), wherein
in either compound,
Ra3 is —H, optionally substituted C1-C6 alkyl, optionally substituted —C1-C4 alkylene-(C6-C10 aryl) or —RPEG1—O—(CH2CH2O)n′—RPEG2;
RPEG1 is C1-C4 alkylene;
RPEG2 is —H or C1-C4 alkyl;
subscript n′ ranges from 1 to 36; and
wherein the basic nitrogen atom bonded to Ra3 is optionally protonated.