Patent ID: 11858958
Assignee: SHANGHAI GINSOME PHARMATECH CO., LTD.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 18:
19. A process for preparing the blank liposome of claim 1, comprising:
step (1): mixing the lipid and the ginsenoside of Formula I together in an organic solvent to obtain a clear solution, optionally, with one or more agents selected from a cholesterol, a long-circulating material, a hydrophobic antioxidant, a soybean oil, a sodium oleate, a hydrophobic surfactant, a hydrophobic heat-sensitive excipient, a hydrophobic pH sensitive material and a hydrophobic ionic additive; wherein the organic solvent is one or more solvents selected from alcohols, halogenated hydrocarbon solvents, and nitrile solvents; wherein the ginsenoside of Formula I is micronized into ultrafine powder with an average particle size no more than 50 μm; or no more than 20 μm, or no more than 10 μm; and
step (2): removing the organic solvent from the clear solution obtained from step (1) to form a film, mixing the film with an aqueous solution comprising a cryoprotectant, optionally, with one or more agents selected from a hydrophilic antioxidant, a hydrophilic surfactant, a hydrophilic heat-sensitive excipient, a hydrophilic pH sensitive material, and a hydrophilic ionic additive to give a mixture; performing an operation of sonication or high pressure homogenization, filtering the mixture to obtain an aqueous solution containing the blank liposome, drying the aqueous solution to obtain the blank liposome of claim 1;
wherein the lipid and the ginsenoside of Formula I are the same as those in claim 1.