Patent ID: 11957713
Assignee: FONDAZIONE TELETHON ETS
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 6:
7. A method of delivering a Hematopoietic Stem Progenitor Cell (HSPC) to a subject that has or is at increased risk of developing a lysosomal storage disorder or neurodegenerative disease, the method comprising administering to the subject a Lin-Hematopoietic Stem Progenitor Cell by Intra-cerebral Ventricular Injection (ICV), wherein the subject was previously treated with a cytotoxic agent or radiation in connection with the ablation of microglia and/or their progenitors wherein the cytotoxic agent is an alkylating agent, and the administration reconstitutes microglia by HSPC engraftment in the subject.