Patent ID: 11891455
Assignee: GALIMEDIX THERAPEUTICS INC
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 4:
5. A process for preparing Form II of (R)-2-[2-amino-3-(indol-3-yl)propionylamino]-2-methylpropionic acid of claim 1, comprising
(a) mixing Form I of (R)-2-[2-amino-3-(indol-3-yl)propionylamino]-2-methylpropionic acid with an aqueous HCl to provide a solution of the compound;
(b) cooling the solution to about 0-5° C., followed by adjusting the pH of the solution to about 5.6 with a base;
(c) stirring the solution at about 0-5° C. until precipitation is complete; and
(d) isolating the resulting precipitate to give the Form II of compound (R)-2-[2-amino-3-(indol-3-yl)propionylamino]-2-methylpropionic acid;
(e) optionally drying the isolated precipitate at 0-5° C. by a drying agent.