Patent ID: 11963997
Assignee: JILIN UNIVERSITY
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 0:
1. A fluorescent polymeric nanomicelle, prepared by dissolving a block copolymer RGD-PHPMA-b-Poly(MMA-alt-(Rhob-MA)) in an organic solvent to obtain a block copolymer solution and adding the block copolymer solution dropwise into an aqueous solution of an anti-tumor polypeptide Bax-BH3 having an amino acid sequence set forth in SEQ ID No. 1, to obtain a fluorescent polymeric nanomicelle, the fluorescent polymeric nanomicelle comprising an anti-tumor polypeptide Bax-BH3 and a polymer carrier,
wherein the anti-tumor polypeptide Bax-BH3 has an amino acid sequence set forth in SEQ ID No. 1, and
wherein the polymer carrier is a block copolymer, the block copolymer is arginyl glycyl aspartic acid-poly(N-(2-hydroxypropyl)methacrylamide)-block polymethacryloyl rhodamine B-polymethyl methacrylate (“RGD-PHPMA-b-Poly(MMA-alt-(Rhob-MA))”).