Patent ID: 11920200
Assignee: GENEDATA AG
Field: Medical technology (Instruments)
Classification: CPC C  G | IPC C  G

Claim 0:
1. A method of determining the presence of a cancer in a human individual, said method comprising:
providing a serum or plasma sample from said human individual, said sample comprising cell-free DNA;
determining, in at least one molecule of said cell-free DNA, the methylation status at 16 CpGs located at positions 28, 31, 33, 45, 52, 58, 60, 62, 69, 104, 107, 110, 116, 121, 124 and 126 within the nucleotide sequence of SEQ ID NO: 2 or a 100% complementary sequence to said nucleotide sequence;
determining the presence of cancer in said human individual when at least one molecule of said cell-free DNA is methylated at each of said 16 CpGs; and
treating the cancer in said human individual by (i) administering a chemotherapeutic agent selected from the group consisting of paclitaxel, docetaxel, cisplatin, liposomal doxorubicin, gemcitabine, trabectedin, etoposide, cyclophosphamide, an angiogenesis inhibitor and a PARP inhibitor, or (ii) by performing tumor de-baulking surgery;
wherein (a) when the human individual is a woman the cancer is selected from the group consisting of: breast cancer, lung squamous cell carcinoma, colon cancer, pancreatic cancer, uterine (endometrial) cancer, and ovarian cancer; or (b) when the human individual is a man the cancer is selected from the group consisting of: lung squamous cell carcinoma, colon cancer, pancreatic cancer and prostate cancer.