Patent ID: 11872225
Assignee: AGIOS PHARMACEUTICALS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 4:
5. The method of claim 1, wherein L1 is C1-6 alkylene substituted with Rj and Rk;
wherein each instance of Rj and Rk is independently selected from H, halogen, —CN, —ORo7, —N(Rn5)2, —N(Rn5)C(═O)Rc5, —C(═O)N(Rn5)2, —C(═O)Rc5, —C(═O)ORo7, —SRjs, —S(═O)2Rjs, or —S(═O)Rjs, optionally substituted —C1-C6 alkyl; or Rj and Rk can be taken together with the carbon atom to form C═O, C═NRjn, an optionally substituted C3-C6 monocyclic cycloalkyl ring or an optionally substituted C3-C6 monocyclic heterocyclyl ring;
each of Rn5 and Rjn is independently hydrogen, optionally substituted —C1-C6 alkyl, —ORo8, or a nitrogen protecting group;
each instance of Ro7 is independently hydrogen, optionally substituted —C1-C6 alkyl, or an oxygen protecting group;
each instance of Rc5 is independently optionally substituted —C1-C6 alkyl; and
each instance of Rjs is independently optionally substituted —C1-C6 alkyl, optionally substituted C6-12 aryl, optionally substituted heteroaryl, or a sulfur protecting group.