Patent ID: 11865159
Assignee: SANOFI
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A

Claim 28:
29. A kit comprising RNA encoding an IL-12sc protein, RNA encoding an IL-15 sushi protein, RNA encoding an IFNα protein, and RNA encoding a GM-CSF protein, wherein the RNAs are not in the same container, wherein each RNA comprises a modified nucleoside in place of each uridine, wherein the modified nucleoside is pseudouridine (ψ), N1-methyl-pseudouridine (m1ψ), 5-methyl-uridine (m5U), or a combination thereof, and wherein
the IL-12sc protein comprises an amino acid sequence having at least 95% identity to the amino acid sequence of SEQ ID NO: 14;
the IL-15 sushi protein comprises an amino acid sequence having at least 95% identity to the amino acid sequence of SEQ ID NO: 24
the IFNα protein comprises an amino acid sequence having at least 95% identity to the amino acid sequence of SEQ ID NO: 19; and
the GM-CSF protein comprises an amino acid sequence having at least 95% identity to the amino acid sequence of SEQ ID NO: 27.