Patent ID: 11944675
Assignee: GLAXOSMITHKLINE BIOLOGICALS SA
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C  Y | IPC A  C

Claim 0:
1. A bioconjugate vaccine comprising:
(i) a protein carrier, which is a modified, genetically detoxified Exotoxin of Pseudomonas aeruginosa (EPA), comprising at least two[[ ]] inserted consensus sequences, D/E-X-N-Z-S/T, wherein X and Z may be any natural amino acid except proline[[ ]]; and
(ii) at least one antigenic polysaccharide from at least one bacterium, N-linked to the protein carrier by attachment of the antigenic polysaccharide to the asparagine residue of the D/E-X-N-Z-S/T consensus sequence, wherein the at least one antigenic polysaccharide is a bacterial 0-antigen from one or more strain of Shigella, Escherichia coli (E. coli) or Pseudomonas aeruginosa; and,
optionally, an adjuvant.