Patent ID: 11939314
Assignee: MERCK PATENT GMBH
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 6:
7. Compounds according to claim 1, selected from the group consisting of
6-fluoro-3-{1-[4-(morpholine-4-carbonyl)-phenyl]-1H-[1,2,3] triazol-4-yl}-1H-quinolin-2-one,
3- {1-[4-(morpholine-4-carbonyl)-phenyl]-1H-[1,2,3] triazol-4-yl}-1H-quinolin-2-one,
N,N-dimethyl-4-[4-(2-oxo-1,2-dihydro-[1, 8]naphthyridin-3-yl)-[1,2,3]triazol-1-yl]-benzamide,
N,N-dimethyl-4-[4-(2-oxo-1,2-dihydro-quinolin-3-yl)-[1,2,3]triazol-1-yl]-benzamide,
3-[1-(4-dimethylaminomethyl-phenyl)- 1H-[1,2,3]triazol-4-yl}-1H-[1, 8]naphthyridin-2-one,
3-(1-phenyl-1H-[1,2,3]triazol-4-yl)- 1H-[1,8]naphthyridin-2-one,
3-[1-(4-hydroxymethyl-phenyl)- 1H-[1,2,3]triazol-4-yl]-1H-[1, 8]naphthyridin-2-one,
N-(2-hydroxy-ethyl)-4-[4-(2-oxo-1,2-dihydro-[1, 8]naphthyridin-3-yl)-[1,2,3]triazol- 1-yl}-benzamide,
N-(2-methoxy-ethyl)-4-[4-(2-oxo-1,2-dihydro-[1, 8]naphthyridin-3-yl)-[1,2,3]triazol- 1-yl}-benzamide,
3-[1-(4-methoxy-phenyl)- 1H-[1,2, 3]triazol-4-yl]-1H-quinolin-2-one,
4-[4-(6-chloro-2-oxo-1,2-dihydro-[1, 8]naphthyridin-3-yl)-[1,2,3]triazol-1-yl]-N,N-dimethyl-benzamide,
3-[1-(4-fluoro-phenyl)-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
3-[1-(2-fluoro-phenyl)-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
3-{1-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one,
N-(1-methyl-piperidin-4-ylmethyl)-4-[4-(2-oxo-1,2-dihydro-quinolin-3-yl)-[1,2,3]triazol-1-yl]-benzamide,
4-[4-(6-methoxy-2-oxo-1,2-dihydro-[1, 8]naphthyridin-3-yl)-[1,2,3]triazol-1-yl]-N,N-dimethyl-benzamide,
4-[4-(2-oxo-1,2-dihydro-quinolin-3-yl)-[1,2,3]triazol-1-yl}-pyridine-2-carboxylic acid methyl ester,
4-[4-(6-fluoro-2-oxo- 1,2-dihydro-quinolin-3-yl)-[1,2, 3]triazol- 1-yl}-N,N-dimethyl-benzamide,
N-(2-hydroxy-ethyl)-4-[4-(2-oxo-1,2-dihydro-quinolin-3-yl)-[1,2,3]triazol-1-yl}-benzamide,
3-[1-(1H-indol-5-yl)-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
N-(2-morpholin-4-yl-ethyl)-4-[4-(2-oxo-1,2-dihydro-quinolin-3-yl)-[1,2,3]triazol-1-yl}-benzamide,
4-[4-(6-fluoro-2-oxo- 1,2-dihydro-quinolin-3-yl)-[1,2, 3]triazol- 1-yl}-N-(1-methyl-piperidin-4-ylmethyl)-benzamide,
3-[4-(2-oxo-1,2-dihydro-quinolin-3-yl)-[1,2, 3]triazol-1-yl]-benzoic acid methyl ester,
3-[1-(3-methoxy-phenyl)-1H-[1,2, 3]triazol-4-yl]-1H-quinolin-2-one,
3-{1-[4-(3-oxo-morpholin-4-yl)-phenyl]-1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one,
3-{1-[4-(2-morpholin-4-yl-ethoxy)-phenyl]-1H-[1,2, 3]triazol-4-yl}-1H-quinolin-2-one,
3-(1-phenyl-1H-[1,2,3]triazol-4-yl)-1H-quinolin-2-one,
3-[1-(3H-benzimidazol-5-yl)- 1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one,
3- {1-[4-(morpholine-4-carbonyl)-phenyl]-1H-[1,2,3] triazol-4-yl}-1H-[1,7]naphthyridin-2-one,
7-methyl-3- {1-[4-(morpholine-4-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-[1,8]naphthyridin-2-one,
6-fluoro-3-{1-[4-(morpholine-4-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-[1,8]naphthyridin-2-one,
3-{1-[3-fluoro-4-(3-oxo-morpholin-4-yl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6-fluoro-3-{1-[3-fluoro-4-(3-oxo-morpholin-4-yl)-phenyl]- 1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
3-{1-[6-(3-oxo-morpholin-4-yl)-pyridin-3-yl]-1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one,
3-{1-[2-methyl-4-(morpholine-4-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
3-{1-[4-(1-hydroxy-1-methyl-ethyl)-phenyl]-1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one,
3-{1-[3-fluoro-4-(morpholine-4-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
3-[1-(3,4,5-trimethoxy-phenyl)-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
2-fluoro-N-methyl-4-[4-(2-oxo-1,2-dihydro-quinolin-3-yl)-[1,2,3]triazol-1-yl]-benzamide,
3-{1-[3-methyl-4-(morpholine-4-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
3-{1-[4-(morpholine-4-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-[1,6]naphthyridin-2-one,
N,N-dimethyl-4-[4-(2-oxo-1,2-dihydro-[1,7]naphthyridin-3-yl)-[1,2,3]triazol-1-yl]-benzamide,
3-(1-phenyl-1H-pyrazol-4-yl)-1H-[1,8]naphthyridin-2-one,
3-(1-phenyl-1H-pyrazol-4-yl)-1H-[1,7]naphthyridin-2-one,
3-[1-(4-fluoro-phenyl)-1H-[1,2,3]triazol-4-yl]-1H-[1,6]naphthyridin-2-one,
3-(1-phenyl-1H-pyrazol-4-yl)-1H-[1,6]naphthyridin-2-one,
3- {1-[4-(morpholine-4-carbonyl)-phenyl]-1H-[1,2,3] triazol-4-yl}-1H-[1, 8]naphthyridin-2-one,
5-fluoro-3-{1-[4-(morpholine-4-carbonyl)-phenyl]-1H-[1,2,3] triazol-4-yl}-1H-quinolin-2-one,
3-{1-[4-(3-oxo-morpholin-4-yl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-[1,7]naphthyridin-2-one,
3-{1-[4-(piperazine- 1-carbonyl)-phenyl]-1H-[1,2,3] triazol-4-yl}-1H-quinolin-2-one,
444-(2-oxo-1,2-dihydro-[1,8]naphthyridin-3-yl)-[1,2,3]triazol-1-yl]-N-piperidin-4-yl-benzamide,
3-[1-(4-piperazin-1-yl-phenyl)-1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one,
6-fluoro-3-{1-[4-(piperazine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
3-[1-(2-piperazin-1-yl-pyrimidin-5-yl)-1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one,
3-[1-(441,41diazepan-1-yl-phenyl)-1H41,2,31triazol-4-yl}-1H-quinolin-2-one,
6-fluoro-3-{1-[4-(4-methyl-piperazine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
3-{1-[4-(4-methyl-piperazine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
N-(1-Methyl-piperidin-4-yl)-4-[4-(2-oxo-1,2-dihydro-quinolin-3-yl)-[1,2,3]triazol-1-yl]-benzamide,
N-methyl-N-(1-methyl-piperidin-4-yl)-4-[4-(2-oxo-1,2-dihydro-quinolin-3-yl)-[1,2,3]triazol-1-yl]-benzamide,
3-{1-[4-(1-methyl-piperidin-4-ylmethoxy)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
3-{1-[4-(4-dimethylamino-piperidine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
3-{1-[4-(4-methyl-piperazine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-[1,6]naphthyridin-2-one,
3-{1-[4-(4-methyl-piperazine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-[1,7]naphthyridin-2-one,
3-{1-[4-(4-methyl-piperazine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-[1,8]naphthyridin-2-one,
7-methyl-3-{1-[4-(4-methyl-piperazine-1-carbonyl)-phenyl]-1H-[,2,3]triazol-4-yl]-1H-[1,8]naphthyridin-2-one,
3-{1-[2-(4-methyl-piperazin-1-yl)-pyrimidin-5-yl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6-fluoro-3-{1-[4-(4-methyl-piperazine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-[1,8]naphthyridin-2-one,
3-{1-[4-(4-methyl-2-oxo-piperazin-1-yl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
3-{1-[4-(4-methyl-[1,4]diazepan-1-yl)-phenyl]-1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one,
6-fluoro-3-{1-[4-(4-methyl-piperazin-1-yl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6-fluoro-3-{1-[4-(4-methyl-2-oxo-piperazin-1-yl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
3-(1-{4-[2-(4-methyl-piperazin-1-yl)-ethoxy]-phenyl 1- 1H-[1,2,3]triazol-4-yl)-1H-quinolin-2-one,
3-{1-[4-(piperazine- 1-carbonyl)-phenyl]-1H-pyrazol-4-yl]-1H-quinolin-2-one,
3-{1-[4-(4-methyl-piperazine-1-carbonyl)-phenyl]-1H-pyrazol-4-yl}-1H-quinolin-2-one,
3-(1-phenyl-1H-pyrazol-4-yl)-1H-quinolin-2-one,
3- {1-[3-(morpholine-4-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
4-[4-(2-Oxo- 1,2-dihydro-[1,8]naphthyridin-3-yl)-[1,2,3]triazol-1-yl]-benzoic acid,
3- {1-[3-(piperazine- 1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
3- {1-[3-(4-methyl-piperazine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
3-[1-(4-isopropenyl-phenyl)- 1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one,
3-{1-[4-(1-methanesulfonyl-1-methyl-ethyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
7-chloro-3-{1-[4-(morpholine-4-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
7-fluoro-3-{1-[4-(morpholine-4-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
7-methyl-3- {1-[4-(morpholine-4-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
3- {1-[4-(morpholine-4-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-[1,5]naphthyridin-2-one,
6-fluoro-3-(1-{4-[4-(3-methoxy-propyl)-piperazine-1-carbonyl]-phenyl}-1H-[1,2,3]triazol-4-yl)-1H-quinolin-2-one,
5-fluoro-3-(1-{4-[4-(3-methoxy-propyl)-piperazine-1-carbonyl]-phenyl}-1H-[1,2,3]triazol-4-yl)-1H-quinolin-2-one,
6-fluoro-3-(1-{4-[4-(3-methoxy-propyl)-piperazine-1-carbonyl]-phenyl}-1H-[1,2,3]triazol-4-yl)-1H-[1, 8]naphthyridin-2-one,
3-(1-{4-[4-(3-methoxy-propyl)-piperazine-1-carbonyl]-phenyl]- 1H-[1,2,3]triazol-4-yl)-1H-[1,8]naphthyridin-2-one,
5,7-difluoro-3- {1-[4-(morpholine-4-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
7-bromo-3- {1-[4-(morpholine-4-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6-fluoro-3-{1-[4-(4-methyl-3-oxo-piperazine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
7-methoxy-3- {1-[4-(morpholine-4-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6- {1-[4-(Morpholine-4-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-8H-pyrido [2,3-d]pyrimidin-7-one,
6-fluoro-3-{1-[3-(2-morpholin-4-yl-ethoxy)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
5,7-difluoro-3-{1-[4-(4-methyl-3-oxo-piperazine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6-chloro-3-{1-[4-(4-methyl-3-oxo-piperazine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
7-chloro-3-{1-[4-(4-methyl-3-oxo-piperazine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6-fluoro-3-{1-[4-(2-oxo-oxazolidin-3-yl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
3-{1-[4-(1,1-dioxo-116-isothiazolidin-2-yl)-phenyl]-1 H-[1,2,3]triazol-4-yl]-6-fluoro- 1 H-quinolin-2-one,
3- {1-[4-([1,3[bipyrrolidinyl- 1′-carbonyl)-phenyl}- 1H-[1,2,3]triazol-4-yl]-6-fluoro-1H-quinolin-2-one,
3-(1-{4-[2-(4-acetyl-piperazin-1-yl)-ethoxy]-phenyl]- 1H-[1,2,3]triazol-4-yl)-6-fluoro-1H-quinolin-2-one,
3-(1-{4-[2-(4-acetyl-piperazin-1-yl)-ethoxy]-phenyl]- 1H-[1,2,3]triazol-4-yl)-6,7-difluoro- 1 H-quinolin-2-one,
acetic acid 1-{4-[4-(6-fluoro-2-oxo- 1,2-dihydro-quinolin-3-yl)-[1,2,3]triazol- 1-yl}-benzoyl]-piperidin-4-yl ester,
acetic acid 1-{4-[4-(6-fluoro-2-oxo- 1,2-dihydro-quinolin-3-yl)-[1,2,3]triazol- 1-yl}-benzoyl]-piperidin- 3-yl ester,
3-{1-[4-([1,3[bipyrrolidinyl-1′-carbonyl)-phenyl}- 1H-[1,2,3]triazol-4-yl]-6,7-difluoro- 1 H-quinolin-2-one,
3-{1-[4-([1,3[bipyrrolidinyl-1′-carbonyl)-phenyl}- 1H-[1,2,3]triazol-4-yl]-5,7-difluoro- 1 H-quinolin-2-one,
6-fluoro-3-{1-[4-(3-methoxymethyl-pyrrolidine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
3-{1-[3-([1,3[bipyrrolidinyl-1′-carbonyl)-phenyl}- 1H-[1,2,3]triazol-4-yl]-6-fluoro-1H-quinolin-2-one,
3-{1-[3-([1,3[bipyrrolidinyl-1′-carbonyl)-phenyl}- 1H-[1,2,3]triazol-4-yl]-6,7-difluoro- 1 H-quinolin-2-one,
6,7-difluoro-3-{1-[4-(3-methoxymethyl-pyrrolidine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6-fluoro-3-{1-[4-(4-methyl-5-oxo-[1,4]diazepane- 1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6-fluoro- 3-{1-[4-((R)- 3-methoxy-pyrrolidine-1-carbonyl)-phenyl}-1 H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6-fluoro-3-{1-[4-((S)-3-methoxy-pyrrolidine-1-carbonyl)-phenyl}-1 H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6,7-difluoro-3-{1-[4-((R)- 3-methoxy-pyrrolidine- 1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6,7-difluoro-3-{1-[4-((S)-3-methoxy-pyrrolidine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
3-{1-[4-(2-dimethylamino-ethyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-6,7-difluoro-1H-quinolin-2-one,
3-{1-[4-(2-diethylamino-ethoxy)-phenyl]-1H-[1,2,3]triazol-4-yl]-6,7-difluoro-1H-quinolin-2-one,
7-fluoro-3-{1-[4-(piperazine- 1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
7-fluoro-3-{1-[4-(4-methyl-piperazine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
5-fluoro-3-{1-[4-(piperazine- 1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
8-fluoro-3-{1-[4-(piperazine- 1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
3-{1-[4-(piperazine- 1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-[1,8]naphthyridin-2-one,
6-fluoro-3-{1-[4-(piperazine- 1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-[1,8]naphthyridin-2-one,
6-chloro-3-{1-[4-(piperazine- 1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
3-[1-(4-[1,4]diazepan- 1-yl-phenyl)- 1H-[1,2,3]triazol-4-yl}-6-fluoro-1H-[1,8]naphthyridin-2-one,
6-fluoro-3- {1-[3-(piperazine- 1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
7-chloro-3-{1-[4-(piperazine- 1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
5,6-difluoro-3-{1-[4-(piperazine- 1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6,7-difluoro-3-{1-[4-(piperazine- 1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6-fluoro-3-{1-[4-(piperazine- 1-sulfonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6,7-difluoro-3-{1-[4-(2-piperazin-1-yl-ethoxy)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6-fluoro-3-{1-[4-(3-piperazin-1-yl-propoxy)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6-fluoro-3- {1-[44piperidine-4-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6-fluoro-3-{1-[442-piperidin-4-yl-ethoxy)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6,7-difluoro-3-{1-[442-piperidin-4-yl-ethoxy)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6,7-difluoro-3-{1-[4-(3-piperazin-1-yl-propoxy)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6,7-difluoro-3- {1-[44piperidine-4-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6-methyl-3-{1-[4-(piperazine- 1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
5,7-difluoro-3- {141-(2-oxo-2-piperazin- 1-yl-ethyl)-1H-indol-5-yl}-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6,7-difluoro-3- {141-(2-oxo-2-piperazin- 1-yl-ethyl)-1H-indol-5-yl}-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6,7-difluoro-3-{1-[4-(2-oxo-2-piperazin-1-yl-ethoxy)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6-fluoro-3-{1-[4-(2-oxo-2-piperazin-1-yl-ethoxy)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
3-{1-[4-(piperazine- 1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-7-trifluoromethyl-1H-quinolin-2-one,
3-{1-[4-(4-amino-piperidine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-6,7-difluoro-1H-quinolin-2-one,
3-{1-[4-(4-amino-piperidine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-6-fluoro-1H-quinolin-2-one,
6,7-difluoro-3-{1-[4-(2-oxo-piperazin-1-yl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6,7-difluoro-3-{1-[1-(2-oxo-2-piperazin-1-yl-ethyl)-1H-indazol-5-yl]-1H41,2,31triazol-4-yl]-1H-quinolin-2-one,
6-fluoro-7-methoxy-3-{1-[4-(piperazine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6-chloro-7-fluoro-3-{1-[4-(piperazine- 1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
5-fluoro-3-{1-[4-(4-methyl-piperazine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
8-fluoro-3-{1-[4-(4-methyl-piperazine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6-chloro-3-{1-[4-(4-methyl-piperazine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
5,7-difluoro-3-{1-[4-(4-methyl-piperazine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6-Fluoro-3-{1-[3-(4-methyl-piperazine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
7-chloro-3-{1-[4-(4-methyl-piperazine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6-fluoro-3-{1-[4-(4-methyl-[1,4]diazepan- 1-yl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-[1,8]naphthyridin-2-one,
5, 6-difluoro-3-{1-[4-(4-methyl-piperazine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6,7-difluoro-3-{1-[4-(4-methyl-piperazine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6-fluoro-3-{1-[4-(4-methyl-piperazine-1-sulfonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6,7-difluoro-3-(1-{4-[2-(4-methyl-piperazin-1-yl)-ethoxy]-phenyl}-1H-[1,2,3]triazol-4-yl)-1H-quinolin-2-one,
6-fluoro-3-(1-{4-[3-(4-methyl-piperazin-1-yl)-propoxyl-phenyl}-1H-[1,2,3]triazol-4-yl)-1H-quinolin-2-one,
6-fluoro-3-{1-[4-(1-methyl-piperidine-4-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6,7-difluoro-3-(1- {4-[3-(4-methyl-piperazin-1-yl)-propoxyl-phenyl}-1H-[1,2,3]triazol-4-yl)-1H-quinolin-2-one,
6-fluoro-3-(1-{4-[2-(1-methyl-piperidin-4-yl)-ethoxy]-phenyl]- 1H-[1,2,3]triazol-4-yl)-1H-quinolin-2-one,
6,7-difluoro-3-{1-[4-(1-methyl-piperidine-4-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6-fluoro-3-(1-{4-[2-(4-methyl-piperazin-1-yl)-2-oxo-ethoxyl-phenyl}-1H-[1,2,3]triazol-4-yl)-1H-quinolin-2-one,
6,7-difluoro-3-(1-{4-[2-(1-methyl-piperidin-4-yl)-ethoxy]-phenyl 1-1H-[1,2,3]triazol-4-yl)-1H-quinolin-2-one,
6,7-difluoro-3-(1-{4-[2-(4-methyl-piperazin-1-yl)-2-oxo-ethoxyl-phenyl}-1H-[1,2,3]triazol-4-yl)-1H-quinolin-2-one,
6-methyl-3-{1-[4-(4-methyl-piperazine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6,7-difluoro-3-(1-{4-[2-(4-methyl-piperazin-1-yl)-2-oxo-ethyl]-phenyl}-1H-[1,2,3]triazol-4-yl)-1H-quinolin-2-one,
3-{1-[4-(4-methyl-piperazine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-7-trifluoromethyl-1H-quinolin-2-one,
3-{1-[4-(4-dimethylamino-piperidine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-6,7-difluoro-1H-quinolin-2-one,
3-{1-[4-(4-dimethylamino-piperidine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-6-fluoro-1H-quinolin-2-one,
6,7-difluoro-3-(1-{1-[2-(4-methyl-piperazin-1-yl)-2-oxo-ethyl]-1H-indazol-5-yl]-1H-[1,2,3]triazol-4-yl)-1H-quinolin-2-one,
6,7-difluoro-3-{1-[4-(4-methyl-2-oxo-piperazin-1-yl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6-Fluoro-3-(1-{4-[4-(2-methoxy-ethyl)-piperazine-1-carbonyl]-phenyl}-1H-[1,2,3]triazol-4-yl)-1H-[1, 8]naphthyridin-2-one,
6-fluoro-3-(1-{4-[2-(4-methyl-piperazin-1-yl)-ethoxy]-phenyl 1- 1H-[1,2,3]triazol-4-yl)-1H-quinolin-2-one,
3- {1-[4-(morpholine-4-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-2-oxo-1,2-dihydro-quinoline-7-carbonitrile,
6-fluoro-3-(1-{1-[2-(4-methyl-piperazin-1-yl)-2-oxo-ethyl]-1H-indol-5-yl}-1H-[1,2,3]triazol-4-yl)-1H-quinolin-2-one,
acetic acid (R)- 1-{4-[4-(6-fluoro-2-oxo- 1,2-dihydro-quinolin-3-yl)-[1,2,3]triazol- 1-yl}-benzoyl}-pyrrolidin-3-yl ester,
acetic acid (S)-1-{4-[4-(6-fluoro-2-oxo- 1,2-dihydro-quinolin-3-yl)-[1,2,3]triazol- 1-yl}-benzoyl}-pyrrolidin-3-yl ester,
6-fluoro-3- {1-[4-((R)-3-hydroxy-pyrrolidine-1-carbonyl)-phenyl}-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6-fluoro-3-{1-[4-((S)-3-hydroxy-pyrrolidine-1-carbonyl)-phenyl}-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6-fluoro-3-{1-[4-(4-hydroxy-piperidine-1-carbonyl)-phenyl]-1 H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6-fluoro-3-{1-[4-(3-hydroxy-piperidine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
4-methyl-3- {1-[4-(morpholine-4-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6,7-Difluoro-3-{1-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
N-(2-diethylamino-ethyl)-4-[4-(6,7-difluoro-2-oxo-1,2-dihydro-quinolin-3-yl)-[1,2,3]triazol-1-yl]-benzamide,
4-[4-(7-chloro-6-fluoro-2-oxo-1,2-dihydro-quinolin-3-yl)-[1,2,3]triazol-1-yl]-N-(2-diethylamino-ethyl)-benzamide,
3-(1-{4-[4-(2-diethylamino-ethyl)-piperazine-1-carbonyl]-phenyl}-1H-[1,2,3]triazol-4-yl)-6,7-difluoro-1H-quinolin-2-one,
6-fluoro-3-{1-[4-(4-methoxy-piperidine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6,7-difluoro-3-{1-[4-(4-methoxy-piperidine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6,7-difluoro-3- {1-[44(R)-3-methoxy-piperidine- 1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6,7-difluoro-3- {1-[44(S)-3-methoxy-piperidine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6-fluoro-3- {1-[4-((R)-3-methoxy-piperidine-1-carbonyl)-phenyl}-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6-fluoro-3-{1-[4-((S)-3-methoxy-piperidine-1-carbonyl)-phenyl}-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
N-(2-diethylamino-ethyl)-4-[4-(6-fluoro-2-oxo-1,2-dihydro-quinolin-3-yl)-[1,2,3]triazol-1-yl]-benzamide,
6-fluoro-3- {1-[4-((S)-2-hydroxymethyl-pyrrolidine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6-fluoro-3-{1-[4-((R)-2-methoxymethyl-pyrrolidine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6-fluoro-3-{1-[4-((R)-3-methoxymethyl-pyrrolidine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6,7-difluoro-3- {1-[4-((R)-3-methoxymethyl-pyrrolidine-1-carbonyl)-phenyl}- 1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6,7-difluoro-3- {1-[4-((S)-3-methoxymethyl-pyrrolidine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6-fluoro-3- {1-[4-((S)-3-methoxymethyl-pyrrolidine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
3-(1-{4-[3-(2-diethylamino-ethoxy)-pyrrolidine- 1-carbonyl]-phenyl}-1H-[1,2,3]triazol-4-yl)-6-fluoro-1H-quinolin-2-one,
6-fluoro-3-{1-[4-(2-oxa-7-aza-spiro [4.4]nonane-7-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6-fluoro-3-{1-[4-(2-oxa-6-aza-spiro[3.4]octane-6-carbonyl)-phenyl}-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6-fluoro-3-{1-[4-(3-hydroxymethyl-pyrrolidine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
3-{1-[4-(3-dimethylamino-pyrrolidine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-6-fluoro-1H-quinolin-2-one,
6-fluoro-3-(1-{4-[3-(4-hydroxy-piperidin-1-yl)-pyrrolidine-1-carbonyl]-phenyl]- 1H-[1,2,3]triazol-4-yl)-1H-quinolin-2-one,
6-fluoro-3-(1-{4-[3-(2-morpholin-4-yl-ethoxy)-pyrrolidine- 1-carbonyl]-phenyl]- 1H-[1,2,3]triazol-4-yl)-1H-quinolin-2-one,
6-fluoro-3-(1-{4-[(R)-3-(2-methoxy-ethoxymethyl)-pyrrolidine- 1-carbonyl]-phenyl]- 1H-[1,2,3]triazol-4-yl)-1H-quinolin-2-one,
4-[4-(6-fluoro-2-oxo- 1,2-dihydro-quinolin-3-yl)-[1,2,3]triazol- 1-yl}-N-(2-methoxy-ethyl)-N-methyl-benzamide,
4-[4-(6,7-difluoro-2-oxo- 1,2-dihydro-quinolin-3-yl)-[1,2,3]triazol- 1-yl]-N-(2-methoxy-ethyl)-N-methyl-benzamide,
6-fluoro-3-{1-[44(R)-3-hydroxymethyl-morpholine-4-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6-fluoro-3-{1-[4-(2-hydroxymethyl-piperidine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6-fluoro-3- {1-[4-((S)-2-methoxymethyl-pyrrolidine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6-fluoro-3- {1-[44(S)-3-hydroxymethyl-morpholine-4-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
3-{1-[44(2S,5S)-2,5-bis-methoxymethyl-pyrrolidine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-6-fluoro-1H-quinolin-2-one,
3-{1-[44(2R,5R)-2,5-bis-methoxymethyl-pyrrolidine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-6-fluoro-1H-quinolin-2-one,
3-{1-[4-((2S,5S)-2,5-bis-methoxymethyl-pyrrolidine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-6,7-difluoro-1H-quinolin-2-one,
3-{1-[44(2R,5R)-2,5-bis-methoxymethyl-pyrrolidine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-6,7-difluoro-1H-quinolin-2-one,
6,7-difluoro-3-(1-{4-[3-(2-morpholin-4-yl-ethoxy)-pyrrolidine-1-carbonyl]-phenyl]- 1H-[1,2,3]triazol-4-yl)-1H-quinolin-2-one,
6-fluoro-7-methyl-3-{1-[4-(4-methyl-piperazine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6,7-difluoro-3-(1- {4-[(R)-3-(2-methoxy-ethoxymethyl)-pyrrolidine-1-carbonyl]-phenyl}-1H-[1,2,3]triazol-4-yl)-1H-quinolin-2-one,
6-fluoro-3-(1-{4-[3-(2-pyrrolidin-1-yl-ethoxy)-pyrrolidine-1-carbonyl]-phenyl]- 1H-[1,2,3]triazol-4-yl)-1H-quinolin-2-one,
6,7-difluoro-3-(1-{4-[3-(2-pyrrolidin-1-yl-ethoxy)-pyrrolidine-1-carbonyl]-phenyl 1-1H-[1,2,3]triazol-4-yl)-1H-quinolin-2-one,
(R)- 1-{4-[4-(6-fluoro-2-oxo- 1,2-dihydro-quinolin-3-yl)-[1,2,3]triazol-1-yl]-benzoyl}-pyrrolidine-3-carboxylic acid amide,
6-fluoro-3-{1-[4-((2S ,4R)-4-hydroxy-2-hydroxymethyl-pyrrolidine-1-carbonyl)-phenyl}- 1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6-fluoro-3-{1-[4-(2-oxa-6-aza-spiro [3.5]nonane-6-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6-fluoro-3-{1-[4-(2-oxa-7-aza-spiro [3.5]nonane-7-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6-fluoro-3-{1-[4-(4-oxetan-3-yl-piperazine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
3-{1-[4-(2,5-dioxa-8-aza-spiro [3.5]nonane- 8-carbonyl)-phenyl}-1H-[1,2,3]triazol-4-yl]-6-fluoro-1H-quinolin-2-one,
4-[4-(6-fluoro-2-oxo- 1,2-dihydro-quinolin-3-yl)-[1,2,3]triazol- 1-yl}-N-oxetan-3-yl-benzamide,
6,7-difluoro-3-(1-14-[(S)-3-(2-methoxy-ethoxymethyl)-pyrrolidine-1-carbonyl]-phenyl}-1H-[1,2,3]triazol-4-yl)-1H-quinolin-2-one,
6-fluoro-3-{1-[4-(2-oxa-5-aza-spiro[3.4]octane-5-carbonyl)-phenyl}-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6-fluoro-3- 1-[4-(2-oxa-6-aza-spiro [3.3]heptane-6-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6-fluoro-3-(1- {4-[(S)-3-(2-methoxy-ethoxymethyl)-pyrrolidine-1-carbonyl]-phenyl]- 1H-[1,2,3]triazol-4-yl)-1H-quinolin-2-one,
3-{1-[4-((3R,4S)-3,4-dimethoxy-pyrrolidine-1-carbonyl)-phenyl}-1H-[1,2,3]triazol-4-yl]-6-fluoro-1H-quinolin-2-one,
4-[4-(6-fluoro-2-oxo-1,2-dihydro-quinolin-3-yl)-[1,2,3]triazol-1-yl]-N,N-bis-(2-methoxy-ethyl)-benzamide,
3-{1-[4-(3-diethylaminomethyl-pyrrolidine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-6,7-difluoro-1H-quinolin-2-one,
N-(3-acetyl-3-aza-bicyclo[3.1.0]hex-6-yl)-4-[4-(6-fluoro-2-oxo-1,2-dihydro-quinolin-3-yl)-[1,2,3]triazol-1-yl]-benzamide,
6-fluoro-3-{1-[4-((2S ,4R)-2-hydroxymethyl-4-methoxy-pyrrolidine-1-carbonyl)-phenyl}- 1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
(S)- 1-{4-[4-(6-fluoro-2-oxo- 1,2-dihydro-quinolin-3-yl)-[1,2,3]triazol-1-yl]-benzoyl}-pyrrolidine-2-carboxylic acid amide,
(S)- 1-{4-[4-(6-fluoro-2-oxo- 1,2-dihydro-quinolin-3-yl)-[1,2,3]triazol-1-yl]-benzoyl}-pyrrolidine-3-carboxylic acid amide,
6-fluoro-3-{1-[4-((2R,4R)-2-hydroxymethyl-4-methoxy-pyrrolidine-1-carbonyl)-phenyl}- 1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6-fluoro-3-{1-[4-(2-oxa-5-aza-spiro[3.5]nonane-5-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6-chloro-3-{1-[4-((S)-2-hydroxymethyl-pyrrolidine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6-chloro-3-{1-[44(2R,4R)-2-hydroxymethyl-4-methoxy-pyrrolidine-1-carbonyl)-phenyl}- 1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one,
6-chloro-3-{1-[4-((2S,4R)-2-hydroxymethyl-4-methoxy-pyrrolidine-1-carbonyl)-phenyl}- 1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6-chloro-3-(1-{4-[3-(4-hydroxy-piperidin-1-yl)-pyrrolidine- 1-carbonyl]-phenyl]-1H-[1,2,3]triazol-4-yl)-1H-quinolin-2-one,
6-chloro-3-{1-[4-(4-oxetan-3-yl-piperazine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6-fluoro-3-(1-{4-[(S)-3-(2-methoxy-ethoxy)-pyrrolidine-1-carbonyl]-phenyl]-1H-[1,2,3]triazol-4-yl)-1H-quinolin-2-one,
6-fluoro-3-(1- {4-[(R)-3-(2-methoxy-ethoxy)-pyrrolidine-1-carbonyl]-phenyl]-1H-[1,2,3]triazol-4-yl)-1H-quinolin-2-one,
6-chloro-3-{1-[4-((S)-2-methoxymethyl-pyrrolidine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6-chloro-3-{1-[4-(3-dimethylamino-pyrrolidine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6-chloro-3-{1-[4-(2-hydroxymethyl-piperidine-1-carbonyl)-phenyl}-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6-chloro-3-{1-[4-(2-oxa-7-aza-spiro [3.5]nonane-7-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6-chloro-3-{1-[4-(2-oxa-6-aza-spiro[3.4]octane-6-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6-chloro-3-{1-[4-(2-oxa-6-aza-spiro [3 0.3]heptane-6-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6-chloro-3-(1- {4-[(S)-3 42-methoxy-ethoxy)-pyrrolidine-1-carbonyl]-phenyl]- 1H-[1,2,3]triazol-4-yl)-1H-quinolin-2-one,
6-chloro-3-(1-{4-[(R)-3-(2-methoxy-ethoxy)-pyrrolidine- 1-carbonyl]-phenyl]- 1H-[1,2,3]triazol-4-yl)-1H-quinolin-2-one,
6-fluoro-3-(1- {4-[(R)-3 42-methoxy-ethoxy)-pyrrolidine-1-carbonyl]-phenyl}-1H-pyrazol-4-yl)-1H-quinolin-2-one,
(R)- 1-{4-[446-fluoro-2-oxo- 1,2-dihydro-quinolin-3-yl)-[1,2,3]triazol-1-yl]-benzoyl}-pyrrolidine-2-carboxylic acid amide,
3-{1-[4-((3R,4R)-3,4-dimethoxy-pyrrolidine-1-carbonyl)-phenyl}-1H-[1,2,3]triazol-4-yl]-6-fluoro-1H-quinolin-2-one,
3-{1-[44(3S,4S)-3,4-dimethoxy-pyrrolidine-1-carbonyl)-phenyl}-1H-[1,2,3]triazol-4-yl]-6-fluoro-1H-quinolin-2-one,
6-fluoro-3- {1-[4-((S)-3-fluoro-pyrrolidine-1-carbonyl)-phenyl}-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6-chloro-3- {1-[4-((S)-3-fluoro-pyrrolidine-1-carbonyl)-phenyl}- 1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
3-{1-[4-(3,3-difluoro-pyrrolidine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-6-fluoro-1H-quinolin-2-one,
6-chloro-3-{1-[4-(3,3-difluoro-pyrrolidine-1-carbonyl)-phenyl]-1 H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6-fluoro-3- {1-[4-((R)-3-fluoro-pyrrolidine-1-carbonyl)-phenyl}- 1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6-chloro-3- {1-[4-((R)-3-fluoro-pyrrolidine-1-carbonyl)-phenyl}-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6-chloro-3-{1-[4-((3R,4R)-3,4-dimethoxy-pyrrolidine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6-chloro-3-{1-[44(3S,4S)-3,4-dimethoxy-pyrrolidine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6-fluoro-3-{1-[4-(pyrrolidine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6-fluoro-3-{1-[44(R)-4-hydroxy-isoxazolidine-2-carbonyl)-phenyl}-1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one,
6-chloro-3-{1-[44(R)-4-hydroxy-isoxazolidine-2-carbonyl)-phenyl}-1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one,
6-fluoro-3-{1-[44(S)-4-hydroxy-isoxazolidine-2-carbonyl)-phenyl}-1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one,
6-chloro-3-{1-[44(S)-4-hydroxy-isoxazolidine-2-carbonyl)-phenyl}-1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one,
6-fluoro-3- {1-[4-((R)-2-pyrrolidin-1-ylmethyl-pyrrolidine-1-carbonyl)-phenyl}- 1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6-fluoro-3-{1-[44(S)-2-pyrrolidin-1-ylmethyl-pyrrolidine-1-carbonyl)-phenyl}- 1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
3- {1-[4-(azetidine-1-carbonyl)-phenyl}-1H-[1,2,3]triazol-4-yl]-6-fluoro-1H-quinolin-2-one,
6-fluoro-3-(1-{4-[2-(4-methyl-piperazine-1-carbonyl)-pyrrolidine-1-carbonyl]-phenyl]-1H-[1,2,3]triazol-4-yl)-1H-quinolin-2-one,
6-fluoro-3-{1-[4-((R)-3-methanesulfonyl-pyrrolidine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6-fluoro-3- {1-[4-((S)-3-methanesulfonyl-pyrrolidine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6-fluoro-3-{1-[4-(3-methanesulfonylmethyl-pyrrolidine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6-fluoro-3-(1-{4-[2-(1-methyl-1H-pyrazol-4-yl)-pyrrolidine-1-carbonyl]-phenyl]-1H-[1,2,3]triazol-4-yl)-1H-quinolin-2-one,
6-fluoro-3-{1-[4-(2-pyridin-3-yl-pyrrolidine-1-carbonyl)-phenyl}-1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one,
6-fluoro-3-(1-{4-[2-(4-methyl-piperazin-1-ylmethyl)-pyrrolidine-1-carbonyl]-phenyl]-1H-[1,2,3]triazol-4-yl)-1H-quinolin-2-one,
6-fluoro-3-{1-[4-(2-methyl-pyrrolidine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6-fluoro-3-{1-[4-(2-methyl-2,6-diaza-spiro [3.4]octane-6-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6-chloro-3-{1-[442-methyl-2,6-diaza-spiro[3.4]octane-6-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6-fluoro-3- {1-[44(3aR,6aR)-5-methyl-hexahydro-pyrrolo [3,4-b]pyrrole- 1-carbonyl)-phenyl}-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6-chloro-3-{1-[44(R)-2-methyl-pyrrolidine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
3-{1-[4-(2,2-dimethyl-pyrrolidine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-6-fluoro-1H-quinolin-2-one,
6-fluoro-3-(1-{4-[3-(4-methyl-piperazine-1-carbonyl)-pyrrolidine- 1-carbonyl]-phenyl]- 1H-[1,2,3]triazol-4-yl)-1H-quinolin-2-one,
6-fluoro-3-{1-[44(R)-2-methyl-pyrrolidine-1-carbonyl)-phenyl}- 1H-pyrazol-4-yl]-1H-quinolin-2-one,
6-fluoro-3-{1-[4-(4-methyl-piperazine-1-carbonyl)-phenyl]-1H-pyrazol-4-yl]-1H-quinolin-2-one,
6-fluoro-3-{1-[44(S)-3-methoxy-pyrrolidine-1-carbonyl)-phenyl]-1H-pyrazol-4-yl]-1H-quinolin-2-one,
6-fluoro-3- {1-[44(R)-3-methoxy-pyrrolidine-1-carbonyl)-phenyl}-1H-pyrazol-4-yl]-1H-quinolin-2-one,
6-fluoro-3-(1-{4-[(S)-342-methoxy-ethoxy)-pyrrolidine- 1-carbonyl]-phenyl}-1H-pyrazol-4-yl)-1H-quinolin-2-one,
3- {1-[44(3R,4R)-3,4-dimethoxy-pyrrolidine-1-carbonyl)-phenyl}-1H-pyrazol-4-yl]-6-fluoro-1H-quinolin-2-one,
6-fluoro-3-{1-[44(2S ,4R)-2-hydroxymethyl-4-methoxy-pyrrolidine-1-carbonyl)-phenyl}- 1H-pyrazol-4-yl]-1H-quinolin-2-one,
6-fluoro-3- {1-[44(2R,4R)-2-hydroxymethyl-4-methoxy-pyrrolidine-1-carbonyl)-phenyl}- 1H-pyrazol-4-yl]-1H-quinolin-2-one,
3- {1-[44(3S ,4S)-3,4-dimethoxy-pyrrolidine-1-carbonyl)-phenyl}-1H-pyrazol-4-yl]-6-fluoro-1H-quinolin-2-one,
6,7-difluoro-3-{1-[4-(4-methyl-piperazine-1-carbonyl)-phenyl]-1H-pyrazol-4-yl]-1H-quinolin-2-one,
6-chloro-3-{1-[444-methyl-piperazine-1-carbonyl)-phenyl]-1H-pyrazol-4-yl]-1H-quinolin-2-one,
3- {1-[44(S)-3-amino-pyrrolidine-1-carbonyl)-phenyl}- 1H-[1,2,3]triazol-4-yl]-6-fluoro-1H-quinolin-2-one,
6,7-difluoro-3- {1-[4-((cis)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carbonyl)-phenyl}- 1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6-fluoro-3-{1-[4-((cis)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carbonyl)-phenyl}- 1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
3- {1-[4-((R)-3-amino-piperidine-1-carbonyl)-phenyl}- 1H-[1,2,3]triazol-4-yl}-6,7-difluoro-1H-quinolin-2-one,
3- {1-[44(S)-3-amino-piperidine-1-carbonyl)-phenyl}-1H-[1,2,3]triazol-4-yl}-6,7-difluoro-1H-quinolin-2-one,
6-Fluoro-3- {1-[4-((R)-3-methylamino-pyrrolidine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6-fluoro-3-{1-[4-((S)-3-methylamino-pyrrolidine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
3- {1-[4-((R)-3-amino-pyrrolidine-1-carbonyl)-phenyl}-1H-[1,2,3]triazol-4-yl]-6-fluoro-1H-quinolin-2-one,
6-fluoro-3- {1-[4-((R)-3-hydroxymethyl-piperazine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6-fluoro-3-{1-[4-((S)-2-hydroxymethyl-piperazine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6-fluoro-3- {1-[4-((R)-2-hydroxymethyl-piperazine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
3-{1-[4-(6-amino-3-aza-bicyclo[3.1.0]hexane-3-carbonyl)-phenyl}-1H-[1,2,3]triazol-4-yl]-6-fluoro-1H-quinolin-2-one,
6-chloro-3- {1-[4-((S)-2-dimethylaminomethyl-pyrrolidine-1-carbonyl)-phenyl}- 1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
3- {1-[4-((S)-2-dimethylaminomethyl-pyrrolidine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-6-fluoro-1H-quinolin-2-one,
3-{1-[4-((R)-2-dimethylaminomethyl-pyrrolidine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-6,7-difluoro-1H-quinolin-2-one,
3-{1-[4-((R)-2-dimethylaminomethyl-pyrrolidine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-6-fluoro-1H-quinolin-2-one,
6-chloro-3-{1-[4-((R)-2-dimethylaminomethyl-pyrrolidine-1-carbonyl)-phenyl}- 1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
3- {1-[4-((S)-2-dimethylaminomethyl-pyrrolidine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-6,7-difluoro-1H-quinolin-2-one,
3- {1-[4-((S)-2-dimethylaminomethyl-pyrrolidine-1-carbonyl)-phenyl]-1H-pyrazol-4-yl]-6-fluoro-1H-quinolin-2-one,
3-{1-[4-((R)-2-dimethylaminomethyl-pyrrolidine-1-carbonyl)-phenyl]-1H-pyrazol-4-yl]-6-fluoro-1H-quinolin-2-one,
3- {1-[44(S)-3-dimethylaminomethyl-pyrrolidine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-6-fluoro-1H-quinolin-2-one,
6-fluoro-3- {1-[4-((cis)-5-methyl-hexahydro-pyrrolo[3,4-c]pyrrole-2-carbonyl)-phenyl}- 1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
3- {1-[4-((R)-3-dimethylamino-piperidine-1-carbonyl)-phenyl}- 1H-[1,2,3]triazol-4-yl]-6,7-difluoro-1H-quinolin-2-one,
3- {1-[44(S)-3-dimethylamino-piperidine-1-carbonyl)-phenyl}- 1H-[1,2,3]triazol-4-yl]-6,7-difluoro-1H-quinolin-2-one,
3-{1-[4-(6-dimethylamino-3-aza-bicyclo[3.1.0]hexane-3-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-6-fluoro-1H-quinolin-2-one,
3- {1-[4-((R)-3-dimethylamino-piperidine-1-carbonyl)-phenyl}- 1H-[1,2,3]triazol-4-yl]-6-fluoro-1H-quinolin-2-one,
3- {1-[44(S)-3-dimethylamino-piperidine-1-carbonyl)-phenyl}- 1H-[1,2,3]triazol-4-yl]-6-fluoro-1H-quinolin-2-one,
3- {1-[4-((R)-3-dimethylamino-piperidine-1-carbonyl)-phenyl}- 1H-[1,2,3]triazol-4-yl]-7-fluoro-1H-quinolin-2-one,
3-{1-[4-((R)-3-dimethylaminomethyl-pyrrolidine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-6-fluoro-1H-quinolin-2-one,
3-{1-[4-((R)-3-dimethylaminomethyl-pyrrolidine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-6,7-difluoro-1H-quinolin-2-one,
3- {1-[44(S)-3-dimethylamino-piperidine-1-carbonyl)-phenyl}- 1H-[1,2,3]triazol-4-yl]-7-fluoro-1H-quinolin-2-one,
3-{1-[44(S)-3-diethylamino-piperidine-1-carbonyl)-phenyl}-1H-[1,2,3]triazol-4-yl]-6-fluoro-1H-quinolin-2-one,
3- {1-[44(R)-3-diethylamino-piperidine-1-carbonyl)-phenyl}-1H-[1,2,3]triazol-4-yl]-6-fluoro-1H-quinolin-2-one,
3-{1-[4-(4-dimethylamino-3,3-difluoro-pyrrolidine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-6-fluoro-1H-quinolin-2-one,
3-{1-[44(S)-3-dimethylaminomethyl-pyrrolidine-1-carbonyl)-phenyl]-1H-pyrazol-4-yl]-6-fluoro-1H-quinolin-2-one,
3-{1-[4-((trans)-3-dimethylamino-4-fluoro-pyrrolidine-1-carbonyl)-phenyl]-1H-[1,2,3]triazol-4-yl]-6-fluoro-1H-quinolin-2-one,
6-fluoro-3-[1-(4-methylamino-phenyl)- 1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one,
(R)-tetrahydro-furan-2-carboxylic acid {4-[4-(6-fluoro-2-oxo- 1,2-dihydro-quinolin-3-yl)-[1,2,3]triazol-1-yl}-phenyl}-methyl-amide,
(S)-tetrahydro-furan-2-carboxylic acid {4-[4-(6-fluoro-2-oxo-1,2-dihydro-quinolin-3-yl)-[1,2,3]triazol-1-yl}-phenyl}-methyl-amide,
tetrahydro-pyran-4-carboxylic acid {4-[4-(6-fluoro-2-oxo-1,2-dihydro-quinolin-3-yl)-[1,2,3]triazol-1-yl}-phenyl}-methyl-amide,
(R)-N-{4-[4-(6-fluoro-2-oxo-1,2-dihydro-quinolin-3-yl)-[1,2,3]triazol-1-yl}-phenyl}-2-methoxy-N-methyl-propionamide,
(2S,4S)-4-methoxy-pyrrolidine-2-carboxylic acid {4-[4-(6-fluoro-2-oxo-1,2-dihydro-quinolin-3-yl)-[1,2,3]triazol- 1-yl]-phenyl}-methyl-amide,
(S)-N-{4-[4-(6-fluoro-2-oxo- 1,2-dihydro-quinolin-3-yl)-[1,2,3]triazol-1-yl}-phenyl}-2-methoxy-N-methyl-propionamide,
1-methyl-piperidine-4-carboxylic acid {4-[4-(6-fluoro-2-oxo- 1,2-dihydro-quinolin-3-yl)-[1,2,3]triazol-1-yl}-phenyl}-methyl-amide,
6-fluoro-3- 1-[54(S)-3-methoxy-pyrrolidine-1-carbonyl)-thiophen-3-yl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6-fluoro-3-{1-[54(R)-3-methoxy-pyrrolidine-1-carbonyl)-thiophen-3-yl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
N-{4-[4-(6,7-difluoro-2-oxo-1,2-dihydro-quinolin-3-yl)-[1,2,3]triazol-1-yl]-phenyl]-N-methyl-acetamide,
N-{4-[4-(6-fluoro-2-oxo- 1,2-dihydro-quinolin-3-yl)-[1,2,3]triazol- 1-yl]-phenyl]-N-methyl-acetamide,
6-fluoro-3-[1-(2-methyl-1-oxo-2, 3-dihydro- 1H-isoindol-5-yl)- 1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one,
6-Fluoro-3- {1-[4-((trans)-3-methoxy-cyclopentyloxy)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6-chloro-3-{1-[4-((1S ,3R)-3-methoxy-cyclopentyloxy)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6-fluoro-3-[1-(4-methoxy-phenyl)-1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one,
6-fluoro-3-{1-[4-((R)-3-methoxy-pyrrolidine-1-sulfonyl)-phenyl}-1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one,
6-chloro-3- {1-[4-((R)-3-methoxy-pyrrolidine-1-sulfonyl)-phenyl}-1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one,
6-fluoro-3- {1-[4-((S)-3-methoxy-pyrrolidine-1-sulfonyl)-phenyl}-1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one,
6-chloro-3-{1-[4-((S)-3-methoxy-pyrrolidine-1-sulfonyl)-phenyl}-1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one,
6-fluoro-3-{1-[4-((1S,2S)-2-methoxy-cyclopentyloxy)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6-chloro-3-[1-(4-cyclopentyloxy-phenyl)- 1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
3-[1-(4-cyclopentyloxy-phenyl)- 1H-[1,2,3]triazol-4-yl}-6-fluoro-1H-quinolin-2-one,
6-fluoro-3-{1-[4-(tetrahydro-furan-3-yloxy)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6-chloro-3-{1-[4-(tetrahydro-furan-3-yloxy)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6-fluoro-3-{1-[44(R)-1-methyl-pyrrolidin-3-yloxy)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6-chloro-3-{1-[44(S)-1-methyl-pyrrolidin-3-yloxy)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6-chloro-3- {1-[4-((R)- 1-methyl-pyrrolidin-3-yloxy)-phenyl]-1H-[1,2,3]triazol-4-yl]-1H-quinolin-2-one,
6-fluoro-3-{1-[44(S)-1-methyl-pyrrolidin-3-yloxy)-phenyl}- 1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one,
6-fluoro-3-{1-[4-(1-methyl-piperidin-4-ylmethyl)-phenyl]-1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one,
6,7-difluoro-3- {1-[4-((S)-1-methyl-pyrrolidin-3-yloxy)-phenyl}- 1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one,
6,7-difluoro-3- {1-[4-((R)-1-methyl-pyrrolidin-3-yloxy)-phenyl}-1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one,
6-chloro-3-{1-[4-(1-methyl-piperidin-4-ylmethyl)-phenyl]-1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one,
6-fluoro-3-{1-[4-(1-methyl-piperidin-4-yloxy)-phenyl]-1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one,
6-chloro-3-{1-[4-(1-methyl-piperidin-4-yloxy)-phenyl]-1H-[1,2,3]triazol-4-yl}-1H-quinolin-2-one,
and pharmaceutically acceptable salts, tautomers and stereoisomers thereof, including mixtures thereof in all ratios.