Patent ID: 11873495
Assignee: IONIS PHARMACEUTICALS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 3:
4. An oligomeric compound comprising a modified oligonucleotide according to the following chemical notation (5′ to 3′):, (SEQ ID NO: 852)

mCes Geo mCes Aes mCes Tds Tds Ads Ads mCds Ads

 

Ads Tds Ads Tds mCes Aeo Tes Aes Te;

wherein,
A=an adenine nucleobase,
mC=a 5-methyl cytosine nucleobase,
G=a guanine nucleobase,
T=a thymine nucleobase,
e=a 2′-MOE modified sugar,
d=a 2′-deoxyribose sugar,
s=a phosphorothioate internucleoside linkage, and
o=a phosphodiester internucleoside linkage.