Patent ID: 11965012
Assignee: TCR2 THERAPEUTICS INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 0:
1. A T cell from a human subject, wherein the T cell comprises a recombinant nucleic acid molecule encoding a T cell receptor (TCR) fusion protein (TFP) comprising:
(a) a TCR subunit comprising (i) an extracellular domain, (ii) a transmembrane domain, and (iii) a TCR intracellular domain comprising a stimulatory domain from an intracellular signaling domain; and
(b) a murine, human or humanized scFv or single domain antibody comprising an antigen binding domain;
wherein the TCR subunit and the antigen binding domain are operatively linked by a linker sequence;
wherein the extracellular domain, the transmembrane domain and the intracellular signaling domain are derived from a single subunit, wherein the single subunit is CD3 epsilon or wherein the single subunit is CD3 gamma;
wherein the extracellular domain comprises at least a portion of an extracellular domain of the single subunit;
wherein the single subunit comprises an amino acid sequence that is at least 85% identical to SEQ ID NO: 56 or SEQ ID NO: 57; and
wherein the TFP functionally interacts with an endogenous TCR subunit when expressed in the T cell.