Patent ID: 11944424
Assignee: DUKE UNIVERSITY
Field: Measurement (Instruments)
Classification: CPC A  G | IPC A  G

Claim 28:
29. A computer system for electronic medical evaluation of lungs of a plurality of different subjects, the computer system comprising at least one processor configured to:
obtain a series of 129Xe free induction decays (FIDs) of a gas exchange region of a lung or lungs of a respective subject during a breathing maneuver;
fit the FIDs with a curve fitting function modeled with one or more non-Lorentzian line shapes;
electronically generate a plurality of 129Xe spectral parameters based on the curve fitting, wherein the plurality of 129Xe spectral parameters include static and/or dynamic 129Xe spectral parameters using plots over time of:
(i) barrier amplitude, barrier chemical shift (ppm), and one or more barrier full width at half maximum (FWHM)(ppm) parameters; and
(ii) red blood cell (RBC) spectral parameters comprising RBC amplitude, RBC chemical shift (ppm), RBC FWHM (ppm), and RBC phase (degrees);
high-pass filter each of the RBC amplitude, RBC chemical shift, RBC phase and RBC FWHM with a 0.5 Hz cutoff frequency to thereby remove residual baseline variation and provide filtered parameter plots of the RBC spectral parameters; and
provide the filtered parameter plots of the RBC spectral parameters to an image processing circuit configured to analyze the filtered parameter plots of the RBC spectral parameters to determine if the respective subject has one or more cardiopulmonary conditions and/or a lung impairment or disease.