Patent ID: 11919917
Assignee: ONO PHARMACEUTICAL CO., LTD.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC C

Claim 0:
1. A compound of the following formula (I-1):, wherein,
X and Y are each independently C—H or a nitrogen atom, provided that both X and Y are not simultaneously C—H,
Z is an oxygen atom or sulfur atom,
T is a carbon atom or nitrogen atom,
Ring A is a 5 to 7-membered monocycle,
Ring B is a 5 to 7-membered monocycle or 8 to 10-membered bicycle,
L1 is a bond, —O—, —CONH—, —CO—, —CO2—, —S—, —SO2— or —SO—,
L2 is a bond, C1-3 alkylene group, C3-7 cycloalkylene group or phenylene group,
R1 is a hydrogen atom, halogen atom, hydroxyl group, cyano group, N(R1a)2, C1-4 alkyl group, carboxy group, C1-4 alkoxycarbonyl group, C1-4 haloalkyl group, methyl-d3 group, C3-7 cycloalkyl group, phenyl group, or 3 to 7-membered monocyclic non-aromatic heterocycle,
wherein (R1a)s are each independently a hydrogen atom or C1-4 alkyl group,
R2c is a hydrogen atom, hydroxyl group, halogen atom, oxo group, nitro group, cyano group, C1-4 alkoxy group, —CH2NR2dR2e, or NR2dR2e,
wherein R2d is a hydrogen atom, C1-4 alkyl group, or RFR, and
R2e is a hydrogen atom,
m is an integer of 0 or 1,
R3 is a hydrogen atom, halogen atom, hydroxyl group, C1-4 alkyl group, C1-4 alkoxy group, C1-4 haloalkyl group, C1-4 haloalkoxy group, or amino group,
n is an integer of 1 to 16, wherein when n is 2 or more, a plurality of R3 may be the same or different,
R4a is a hydrogen atom, C1-4 alkyl group, carboxy group, or RFR,
R5 is a C1-4 alkyl group, p represents an integer of 0 to 5, wherein when p is 2 or more, a plurality of R5 may be the same or different,
R6a is a hydrogen atom, C1-4 alkyl group, or RFR,
R7 is a hydrogen atom,
b is the bonding position of Ring B,
RFR represents —(CRFb2)qOP(═O)(ORFa)2,
wherein (RFa)s are independently a hydrogen atom, C1-4 alkyl group, C3-6 cycloalkyl group, —(CH2)2OH, or —CH2OCO2CH(CH3)2,
(RFb)s are independently a hydrogen atom or methyl group, and
q is an integer of 1 or 2, wherein a plurality of RFb may be the same or different,
with proviso that two or more of R2d, R4a, and R6a are not simultaneously RFR,
or a pharmaceutically acceptable salt thereof or a solvate thereof.