Patent ID: 11918661
Assignee: PURDUE RESEARCH FOUNDATION
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 16:
17. A nano-droplet compositioon comprising a fluorocarbon core and a polymeric shell, wherein:
the fluorocarbon core and the polymeric shell form a micelle with a size range of 10-1,000 nm:
the fluorocarbon core comprises at least one fluorocarbon compound with a formula of CnF2n+2 and n is 5-10;
the polymeric shell comprises a biocompatible polymeric material, wherein the biocompatible polymeric mterial comprises bovine serum albumin, alone or in further combination with a polysaccharide, a protein, a peptide, a lipid, a nucleic acid, or any combination thereof, and is optionally modified with various ligands to turn the nano-droplet into a multi-functional agent suitable for targeted diagnostics and therapy;
the fluorocarbon compound is substantially in liquid form; and
wherein the nano-droplet composition has enhance echogenicity in the absence of a transient or complete phase change of the fluorocarbon core from being subjected to a controlled temperature modulation process.