Patent ID: 11951158
Assignee: LINDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A

Claim 0:
1. A method of preventing or treating surfactant deficiency or dysfunction in a patient in need thereof, comprising aerosol administration of composition comprising:
a PPAR (peroxisome proliferator-activated receptor) gamma agonist;
one or more surfactant peptides; and
one or more phospholipids,
wherein the patient is an infant wherein at least one of the one or more surfactant peptides comprises:
(i) a first fragment comprising the amino acid sequence of XWLXRALIKRIQAZI (SEQ ID NO: 1) or a first amino acid sequence having at least 90% sequence identity to SEQ ID NO: 1 and
(ii) a second fragment comprising the amino acid sequence of RZLPQLVXRLVLRXS (SEQ ID NO: 2) or a second amino acid sequence having at least 90% sequence identity to SEQ ID NO: 2,
wherein (a) X is any amino acid but at least one amino acid at the X positions is tyrosine, and (b) Z is any amino acid but not methionine.