Patent ID: 11883537
Assignee: AXIAL THERAPEUTICS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 0:
1. A sustained-release solid dosage form of epigallocatechin gallate (EGCG), comprising a plurality of solid particulates selected from mini-tablets, beads, granules, and pellets, or being in a form of a single solid dosage form, and wherein the solid particulates or the single solid dosage form each comprise:
a core comprising EGCG and a release rate controlling material
selected from the group consisting of hydroxypropyl methyl cellulose, acrylic ester copolymer, methacrylic ester copolymer, and alkylammonium methacrylate copolymer;
wherein the sustained-release solid dosage form releases 10-50% of the EGCG within 24 hours, 30-80% of the EGCG within 48 hours, and at least 60% of the EGCG within 72 hours of administration of said dosage form to a human subject;
wherein the sustained-release solid dosage form comprises a total amount of EGCG in the range of from about 50 mg to about 1,000 mg; and
wherein the EGCG has a purity of at least 98%.