Patent ID: 11890337
Assignee: CHILDREN'S HOSPITAL MEDICAL CENTER
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 0:
1. A method for protecting an individual in need thereof against an Ebola virus species selected from Zaire (EBOV), Sudan (SUDV), Bundibugyo (BDBV), Tai Forest (TAFV), and combinations thereof, comprising administering a virus-like particle (VLP)-based bivalent vaccine composition comprising a spherical retroviral Group-specific Antigen (“Gag”) protein core and at least two species of Ebola glycoproteins; wherein said at least two species of Ebola glycoproteins are incorporated into a surface of a spherical Gag core;
wherein said VLP-based bivalent vaccine presents at least two species of Ebola glycoprotein antigens; and
wherein said spherical Gag protein core has a diameter of from about 100 to about 300 nanometers.