Patent ID: 11919904
Assignee: INCYTE CORPORATION
Field: Measurement (Instruments)
Classification: CPC C  A  G | IPC A  C  G

Claim 29:
30. A method of treating a human subject having a disease or disorder associated with cyclin-dependent kinase 2 (CDK2), comprising:
(i) identifying, in a biological sample obtained from the human subject:
(a) a nucleotide sequence encoding a p16 protein comprising the amino acid sequence of SEQ ID NO:1; and/or
(b) a cyclin dependent kinase inhibitor 2A (CDKN2A) gene lacking one or more inactivating nucleic acid substitutions and/or deletions;

(ii) identifying, in a biological sample obtained from the human subject:
(a) an amplification of the cyclin E1 (CCNE1) gene; and/or
(b) an expression level of CCNE1 that is higher than a control expression level of CCNE1; and

(iii) administering a compound of claim 1, or a pharmaceutically acceptable salt thereof, to the human subject.