Patent ID: 11939331
Assignee: INCYTE CORPORATION
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 33:
34. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein:
R1 is selected from H, C1-6 alkyl, C2-6 alkynyl, C3-10 cycloalkyl, 4-10 membered heterocycloalkyl, C6-10 aryl, and 5-10 membered heteroaryl; wherein said C1-6 alkyl, C2-6 alkynyl, C3-10 cycloalkyl, 4-10 membered heterocycloalkyl, C6-10 aryl, and 5-10 membered heteroaryl are each optionally substituted with 1, 2, 3, or 4 substituents independently selected from R10;
R2 is H;
R3 is H;
R4 is H;
R5 is selected from H, C1-6 alkyl, and C6-10 aryl; wherein said C1-6 alkyl and C6-10 aryl are each optionally substituted with 1, 2, 3, or 4 substituents independently selected from R50;
Z is CR6;
R6 is H;
each R10 is independently selected from C1-6 alkyl, C1-6 haloalkyl, C3-10 cycloalkyl, 4-10 membered heterocycloalkyl, ORa10, C(O)NRc10Rd10, and NRc10Rd10; wherein said C1-6 alkyl, C3-10 cycloalkyl, and 4-10 membered heterocycloalkyl are each optionally substituted with 1, 2, 3, or 4 substituents independently selected from R11;
each R11 is independently selected from C1-6 alkyl, 4-10 membered heterocycloalkyl, C6-10 aryl, 5-10 membered heteroaryl, CN, ORa11, C(O)Rb11, C(O)NRc11Rd11, NRc11Rd11 and S(O)2Rb11; wherein said C1-6 alkyl, 4-10 membered heterocycloalkyl, C6-10 aryl, and 5-10 membered heteroaryl are each optionally substituted with 1, 2, 3, or 4 substituents independently selected from R12;
each R12 is independently selected from C1-6 alkyl, halo, CN, ORa12, and C(O)Rb12; wherein said C1-6 alkyl is optionally substituted with 1 or 2 substituents independently selected from Rg;
each R50 is independently selected from halo;
each Ra10, Rc10 and Rd10 is independently selected from H and C1-6 alkyl; wherein said 6 alkyl is optionally substituted with 1, 2, 3, or 4 substituents independently selected from R11;
or any Rc10 and Rd10 attached to the same N atom, together with the N atom to which they are attached, form a 6- or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from R11;
each Ra11, Rb11, Rc11 and Rd11 is independently selected from H and C1-6 alkyl; wherein said C1-6 alkyl is optionally substituted with 1, 2, 3, or 4 substituents independently selected from R12;
each Ra12 and Rb12 is independently selected from H and C1-6 alkyl; wherein said C1-6 alkyl is optionally substituted with Rg; and
Rg is OH.