Patent ID: 11890351
Assignee: THE TRUSTEES OF BOSTON COLLEGE
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 0:
1. A chemoselectively modified biomolecular conjugate comprising a protein, polypeptide or a peptide comprising naturally-occurring amino acids and one, or more, non-naturally-occurring amino acids comprising a surface-exposed 5-hydroxytryptophan or a 5-aminotryptophan moiety incorporated into the protein, polypeptide or peptide, wherein the non-naturally-occurring amino acid comprising the 5-hydroxytryptophan or the 5-aminotryptophan is chemoselectively modified over the naturally-occurring amino acids of the biomolecule, wherein the 5-hydroxytryptophan or the 5-aminotroptophan is covalently coupled to an aryl-diazonium compound selected from the group consisting of: 4-nitorbenzenediazonium (4NDz); 4-carboxybenzenediazonium (4NCDz) or 4-methoxvhenzenediazonium (4MCDz).