Patent ID: 11926656
Assignee: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A protein comprising:
a polypeptide sequence at least 85% identical to the amino acid sequence of the complement receptor 2 (CR2)-binding region of Epstein-Barr virus (EBV) gp350 set forth as amino acid residues 2-425 of SEQ ID NO: 124, wherein the amino acid residue corresponding to amino acid D296 of SEQ ID NO: 124 is substituted with arginine,
wherein the protein can bind an anti-gp350 antibody, or a B-cell expressing an anti-gp350 B-cell receptor (BCR), wherein binding of the B-cell is through the BCR, and wherein binding of the protein to CR2 is substantially reduced compared binding of wild-type gp350 to CR2.