Patent ID: 11897880
Assignee: JANSSEN PHARMACEUTICA NV
Field: Organic fine chemistry (Chemistry)
Classification: CPC C | IPC C

Claim 8:
9. The compound of claim 1, selected from the group consisting of
(R*)-12-(5-(1H-benzo[d]imidazol-5-yl)-1H-imidazol-2-yl)-7-chloro-8-fluoro-13,14-dihydro-2H-spiro[benzo[5,6]azocino[4,3-g]indolizine-3,1′-cyclopropane]-1,10(4H,12H)-dione;
(S*)-12-(5-(1H-indol-5-yl)-1H-imidazol-2-yl)-7-chloro-8-fluoro-13,14-dihydro-2H-spiro[benzo[5,6]azocino[4,3-g]indolizine-3,1′-cyclopropane]-1,10(4H,12H)-dione;
(S)-12-(5-(6-amino-2-fluoropyridin-3-yl)-1H-imidazol-2-yl)-7-chloro-8-fluoro-13,14-dihydro-2H-spiro[benzo[5,6]azocino[4,3-g]indolizine-3,1′-cyclopropane]-1,10(4H,12H)-dione;
(S*)-12-(5-(6-amino-2-chloropyridin-3-yl)-1H-imidazol-2-yl)-7-chloro-8-fluoro-13,14-dihydro-2H-spiro[benzo[5,6]azocino[4,3-g]indolizine-3,1′-cyclopropane]-1,10(4H,12H)-dione;
(R*)-12-(5-(6-amino-2-chloropyridin-3-yl)-1H-imidazol-2-yl)-7-chloro-8-fluoro-3,4,13,14-tetrahydrobenzo[5,6]azocino[4,3-g]indolizine-1,10(2H,12H)-dione;
(S*)-12-(5-(6-amino-2-fluoropyridin-3-yl)-1H-imidazol-2-yl)-7-chloro-8-fluoro-3,3-dimethyl-3,4,13,14-tetrahydrobenzo[5,6]azocino[4,3-g]indolizine-1,10(2H,12H)-dione;
(S*)-12-(5-(6-amino-2-fluoropyridin-3-yl)-1H-imidazol-2-yl)-7-chloro-8-fluoro-13,14-dihydro-2H-spiro[benzo[5,6]azocino[4,3-g]indolizine-3,1′-cyclobutane]-1,10(4H,12H)-dione;
(S*)-12-(5-(6-amino-2-fluoropyridin-3-yl)-1H-imidazol-2-yl)-7-chloro-8-fluoro-13,14-dihydro-2H-spiro[benzo[5,6]azocino[4,3-g]indolizine-3,1′-cyclopentane]-1,10(4H,12H)-dione;
(S*)-12-(5-(6-amino-2-fluoropyridin-3-yl)-1H-imidazol-2-yl)-7-chloro-8-fluoro-2-methyl-13,14-dihydro-2H-spiro[benzo[5,6]azocino[4,3-g]indolizine-3,1′-cyclopropane]-1,10(4H,12H)-dione;
and pharmaceutically acceptable salt thereof.