Patent ID: 11951240
Assignee: GAMBRO LUNDIA AB
Field: Medical technology (Instruments)
Classification: CPC A | IPC A

Claim 32:
33. The CRRT apparatus of claim 2, wherein the control unit is configured to calculate the steady state acid-base balance parameter in the blood of the patient according to any one of the following definitions:, nNBL
  =
  
   
    
     J
     
      buffer
      ⁢
      _
      ⁢
      load
     
    
    BW
   
   =
   
    
     
      J
      
       met
       ⁢
          
       cit
      
     
     +
     
      J
      
       HCO
       ⁢
       3
       ⁢
          
       bal
      
     
    
    BW
   
  
 

 or

 
  NBL
  =
  
   
    J
    
     buffer
     ⁢
     _
     ⁢
     load
    
   
   =
   
    
     J
     
      met
      ⁢
      _
      ⁢
      cit
     
    
    +
    
     J
     
      HCO
      ⁢
      3
      ⁢
      
       _
       ⁢
       bal, when acid infusion is considered, the control unit is configured to calculate the steady state acid-base balance parameter in the blood of the patient as follows:, nNBL
  =
  
   
    
     J
     
      buffer
      ⁢
      _
      ⁢
      load
     
    
    BW
   
   =
   
    
     
      J
      
       met
       ⁢
       _
       ⁢
       cit
      
     
     +
     
      J
      
       HCO
       ⁢
       3
       ⁢
       
        _
        ⁢
        bal
       
      
     
     -
     
      J
      
       H
       +
      
     
    
    BW
   
  
 

 or

 
  NBL
  =
  
   
    J
    
     buffer
     ⁢
     _
     ⁢
     load
    
   
   =
   
    
     J
     
      met
      ⁢
      _
      ⁢
      cit
     
    
    +
    
     J
     
      HCO
      ⁢
      3
      ⁢
      
       _
       ⁢
       bal
      
     
    
    -
    
     J
     
      H
      +, when also lactate balance is considered, the control unit is configured to determine the steady state acid-base balance parameter in the blood of the patient as follows:, nNBL
  =
  
   
    
     J
     
      buffer
      ⁢
      _
      ⁢
      load
     
    
    BW
   
   =
   
    
     
      J
      
       met
       ⁢
       _
       ⁢
       cit
      
     
     +
     
      J
      
       HCO
       ⁢
       3
       ⁢
       
        _
        ⁢
        bal
       
      
     
     -
     
      J
      
       met
       ⁢
       _
       ⁢
       lact
      
     
     -
     
      J
      
       H
       +
      
     
    
    BW
   
  
 

 or

 
  nNBL
  =
  
   
    J
    
     buffer
     ⁢
     _
     ⁢
     load
    
   
   =
   
    
     J
     
      met
      ⁢
      _
      ⁢
      cit
     
    
    +
    
     J
     
      HCO
      ⁢
      3
      ⁢
      
       _
       ⁢
       bal
      
     
    
    +
    
     J
     
      HCO
      ⁢
      3
      ⁢
      
       _
       ⁢
       lact
      
     
    
    -
    
     J
     
      H
      +, wherein:
nNBL is the steady state acid-base balance parameter,
Jbuffer_load is a mass transfer rate of a net buffer during extracorporeal therapy,
Jmet_cit is a mass transfer rate of bicarbonate generated from the metabolism of citrate infused to the patient,
JHCO3bal is a mass transfer rate of bicarbonate balance during extracorporeal therapy,
Jmet_lact is a mass transfer rate of lactate infused to the patient,
JH+ is a mass transfer rate of acid infusion, and
BW is a body weight of the patient.