Patent ID: 11866772
Assignee: ROCHE MOLECULAR SYSTEMS, INC.
Field: Computer technology (Electrical engineering)
Classification: CPC C  G | IPC C  G

Claim 6:
7. The computer product of claim 1, wherein calculating the minimal input number of control chromosome molecules for the dPCR experiment is determined by:, μ
      ^
     
     pc
    
    =
    
     
      
       (
       
        
         
          
           z
           
            1
            -
            β
           
          
          ⁢
          
           
            1
            +
            
             g
             ⁡
             (
             h
             )
            
           
          
         
         +
         
          
           z
           
            1
            -
            α
           
          
          ⁢
          
           
            1
            +
            
             g
             ⁡
             (
             1
             )
            
           
          
         
        
        
         2
         ⁢
         
          (
          
           
            
             g
             ⁡
             (
             h
             )
            
           
           -
           
            
             g
             ⁡
             (
             1
             )
            
           
          
          )
         
        
       
       )
      
      2
     
     -
     
      3
      8
     
    
   
   ,
   where
  
  ⁢
  

  
   
    
     g
     ⁡
     (
     h
     )
    
    =
    
     
      1
      R
     
     ⁢
     
      
       (
       
        hf
        +
        1
        -
        f
       
       )
      
      .
     
    
   
   ,, where ƒ is the fetal DNA fraction, h is the degree of aneuploidy, R corresponds to a ratio of PCR efficiencies at loci of the control chromosome and the test chromosome, g(1) is the value of g(h) when h=1, α is the false positive rate and β is the false negative rate, z1-α is the 100(1−α)% th quantile of the standard Normal distribution, z1-β is the 100(1−β)% th quantile of the standard Normal distribution.