Patent ID: 11890353
Assignee: NORTHWESTERN UNIVERSITY
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 10:
11. A method of making an in vivo model for detecting anti-poly(ethylene glycol) (PEG) antibodies and an immune response to PEG-containing compounds recognized by the anti-PEG antibodies, the method comprising:
(a) administering subcutaneously to an animal model a composition comprising at least one commercially available antibody against one or more poly(ethylene glycol) chains with a molecular weight of at least 550 Da, wherein the at least one commercially available antibody is selected from antibody clone 1D9-6, antibody clone 5E10E9, antibody clone 5D6-3, and antibody clone 09F02;
(b) administering one or more booster injections subcutaneously at least 14 days after step (a); and
(c) detecting anti-PEG antibodies within the animal model at a level of at least 44 ng/ml.