Patent ID: 11938178
Assignee: DBV TECHNOLOGIES
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A

Claim 15:
16. A method for providing a boosting vaccination against Bordetella pertussis in a primed subject in need thereof, which comprises:
(i) performing skin micro-perforation in a skin area in the subject with a laser microporator, and
(ii) epicutaneously administering a detoxified pertussis toxin (PT) at an amount from 5 μg to 200 μg on said skin area of the subject by means of a skin patch which is applied on the micro-perforated skin area during at least 12 hours
wherein:
skin micro-perforation is performed so as to form an array of micropores on the skin with a micropore depth from 10 μm to 70 μm, and a micropore density from 5% to 11%, said micropores extending from the surface of the skin through one or several epidermis layers, but without extending to the dermis and the skin micro-perforation does not alter the basal layer of the epidermis;
the skin patch in step (ii) is occlusive and comprises a backing suitable to create a hermetically closed condensation chamber on skin, and wherein the antigen is deposited on the skin facing side of said backing, in dry form, and optionally in combination with one or several pharmaceutically acceptable excipients.