Patent ID: 11926644
Assignee: CORNELL UNIVERSITY
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 10:
11. A method for increasing cell NAD+production or for improving mitochondrial densities in a cell comprising administering to a cell a compound of formula (I):, , wherein R1, R2, and R3 are independently selected from hydrogen, formyl, optionally substituted C1-C12 alkylcarbonyl, and optionally substituted C6-C10 arylcarbonyl,
X is NHR4, NR4R5, or OR6,
R4 and R5 are independently optionally substituted C1-C12 alkyl or optionally substituted C6-C10 aryl, and
R6 is hydrogen, optionally substituted C1-C12 alkyl, or optionally substituted C6-C10 aryl,
wherein the alkyl or aryl portion of R4-R6 is optionally substituted with one or more substituents selected from halo, amino, alkyl, alkoxy, aryloxy, hydroxyalkyl, and any combination thereof,
wherein the compound of formula (I) has an octanol-water partition coefficient (cLogP) of at least 0.11,
with the provisos that, when X is OR6 and R6 is hydrogen, R1, R2, and R3 are not all hydrogen or all acetyl,
when X is OR6 and R6 is hydrogen, R1 is not benzoyl and R2 and R3 are not hydrogen, and
when X is OR6 and R6 is methyl, ethyl, or propyl, R1, R2, and R3 are not all acetyl,
or a salt thereof,
wherein the method increases cell NAD+production or improves mitochondrial densities in the cell.