Patent ID: 11931429
Assignee: RAMOT AT TEL-AVIV UNIVERSITY LTD.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C  Y | IPC A  C

Claim 1:
2. The conjugate of claim 1, wherein:
(i) R1 is a linear or branched (C1-C8)alkyl; or
(ii) R2 and R3 together with the carbon atom to which they are attached form a fused, spiro or bridged polycyclic ring; or
(iii) said R4 caging group is selected from the group consisting of:, 2,4-dinitrobenzene
3,4,6-trimethyl-

TBDMS
sulfonate
2,5-dioxobenzyl

 

 

2-(3-carboxy-4-nitro-

4,4,5,5-

phenyl) disulfanylethyloxy
4-azidobenzyloxy
tetramethyl-1,3,2-

carbonyl
carbonyl
dioxaborolanyl

 

4-[4,4,5,5-tetramethyl-

1,3,2-dioxaborolanyl]benzyl
—B(OH)2
phosphonate

 

 

galactosyl
glucosyl
glucuronyl

 

 

wherein Pep is a peptide consisting of at least two amino acid residues and linked via a carboxylic group thereof; or

(iv) at least one of R7, R8 and R9 is H, and the other of R7, R8 and R9 each independently is an electron acceptor group selected from the group consisting of halogen, —NO2 and —CN; or
(v) X1 is (C1-C18)alkylene, (C6-C14)arylene-diyl, or (C1-C18)alkylene-(C6-C14)arylene-diyl, optionally substituted by one or more groups each independently selected from the group consisting of halogen, —COH, —COOH, —OCOOH, —OCONH2, —CN, —NO2, —SH, —OH, —NH2, —CONH2, —SO2H, —SO3H, —S(═O)H, (C6-C10)aryl, (C1-C4)alkylene-(C6-C10)aryl, heteroaryl, and (C1-C4)alkylene-heteroaryl, and said (C1-C18)alkylene being further optionally interrupted by one or more identical or different heteroatoms selected from the group consisting of S, O and N, and/or at least one group each independently selected from the group consisting of —NH—CO—, —CO—NH—, —N(C1-C8alkyl)-, —N(C6-C10)aryl)-, (C6-C10)arylene-diyl, and heteroarylenediyl; and X2 is —C(O)—; or
(vi) Z is selected from the group consisting of Z1, Z2, Z3, Z4, Z5, and Z6:, Z1

 

 

Z2

 

 

Z3

 

 

Z4

 

 

Z5

 

 

Z6