Patent ID: 11866393
Assignee: ZHEJIANG UNIVERSITY
Field: Organic fine chemistry (Chemistry)
Classification: CPC C | IPC C

Claim 2:
3. A method for preparing the compound represented by formula I according to claim 1, comprising using a racemic or optically active 3,3,3′,3′-tetramethyl-1,1′-spirobiindane-6,6′-diol represented by formula 1 as a raw material, and the following steps:
under the condition that R2 is selected from C1-C10 alkyl or perfluoroalkyl and C3-C6 cycloalkyl, subjecting a compound represented by formula 1 to a halogenation reaction to obtain a compound 2, subjecting the compound 2 to an esterification reaction with trifluoromethanesulfonic anhydride to obtain a compound 3, and then subjecting the compound 3 to a palladium-catalyzed coupling reaction or a reduction reaction to obtain the compound represented by formula I;, , or
under the condition that R2 is hydrogen, subjecting the compound represented by formula 1 to a tert-butylation reaction to obtain a compound A2, subjecting the compound A1 to a halogenation reaction to obtain a compound 4, subjecting the compound 4 to a tert-butyl elimination reaction to obtain a compound 5, subjecting the compound 5 to an esterification reaction with trifluoromethanesulfonic anhydride to obtain a compound 6, and then subjecting the compound 6 to a palladium-catalyzed coupling reaction or a reduction reaction to obtain the compound represented by formula I;, wherein X is halogen, and R1 is as defined in claim 1.