Patent ID: 11939340
Assignee: PRELUDE THERAPEUTICS INCORPORATED
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 13:
14. The compound of claim 1 that is:
9a-isopropyl-2-(2-((1-(methylsulfonyl)piperidin-4-yl)amino)-5-(trifluoromethyl) pyrimidin-4-yl)-7,8,9,9a-tetrahydrothieno[2,3-a]indolizin-4(6H)-one;
(9aS)-9a-isopropyl-2-(2-((1-(methylsulfonyl)piperidin-4-yl)amino)-5-(trifluoro-methyl) pyrimidin-4-yl)-7,8,9,9a-tetrahydrothieno[2,3-a]indolizin-4(6H)-one;
(9aR) 9a-Isopropyl-2-(2-((1-(methylsulfonyl)piperidin-4-yl)amino)-5-(trifluoro-methyl) pyrimidin-4-yl)-7,8,9,9a-tetrahydrothieno[2,3-a]indolizin-4(6H)-one;
9a-(3-hydroxypropyl)-2-(2-((1-(methylsulfonyl)piperidin-4-yl)amino)-5-(trifluoro-methyl) pyrimidin-4-yl)-7,8,9,9a-tetrahydrothieno[2,3-a]indolizin-4(6H)-one;
9a-(2-hydroxyethyl)-2-(2-((1-(methylsulfonyl)piperidin-4-yl)amino)-5-(trifluoro-methyl) pyrimidin-4-yl)-7,8,9,9a-tetrahydrothieno[2,3-a]indolizin-4(6H)-one;
2-(5-fluoro-2-((1-(methylsulfonyl)piperidin-4-yl)amino)pyrimidin-4-yl)-9a-methyl-7,8,9,9a-tetrahydrothieno[2,3-a]indolizin-4(6H)-one;
(9aS)-2-(5-Fluoro-2-((1-(methylsulfonyl)piperidin-4-yl)amino)pyrimidin-4-yl)-9a-methyl-7,8,9,9a-tetrahydrothieno[2,3-a]indolizin-4(6H)-one;
(9aR)-2-(5-Fluoro-2-((1-(methylsulfonyl)piperidin-4-yl)amino)pyrimidin-4-yl)-9a-methyl-7,8,9,9a-tetrahydrothieno[2,3-a]indolizin-4(6H)-one;
2-(5-Fluoro-2-((1-(methylsulfonyl)piperidin-4-yl)amino)pyrimidin-4-yl)-9a-isopropyl-7,8,9,9a-tetrahydrothieno[2,3-a]indolizin-4(6H)-one;
10a-Isopropyl-2-(2-((1-(methylsulfonyl)piperidin-4-yl)amino)-5-(trifluoromethyl) pyrimidin-4-yl)-6,7,10,10a-tetrahydrothieno[2′,3′:3,4]pyrrolo[1,2-d][1,4]oxazepin-4(9H)-one;
8a-Isopropyl-2-(2-((1-(methylsulfonyl)piperidin-4-yl)amino)-5-(trifluoromethyl) pyrimidin-4-yl)-6,7,8,8a-tetrahydro-4H-thieno[2,3-a]pyrrolizin-4-one;
(8aS)-8a-Isopropyl-2-(2-((1-(methylsulfonyl)piperidin-4-yl)amino)-5-(trifluoro-methyl) pyrimidin-4-yl)-6,7,8,8a-tetrahydro-4H-thieno[2,3-a]pyrrolizin-4-one;
(8aR)-8a-Isopropyl-2-(2-((1-(methylsulfonyl)piperidin-4-yl)amino)-5-(trifluoro-methyl) pyrimidin-4-yl)-6,7,8,8a-tetrahydro-4H-thieno[2,3-a]pyrrolizin-4-one;
8a-Ethyl-2-[2-[(1-methylsulfonylpiperidin-4-yl)amino]-5-(trifluoromethyl) pyrimidin-4-yl]-7,8-dihydro-6H-thieno[2,3-a]pyrrolizin-4-one;
8a-Ethyl-2-[5-fluoro-2-[(1-methylsulfonylpiperidin-4-yl)amino]pyrimidin-4-yl]-7,8-dihydro-6H-thieno[2,3-a]pyrrolizin-4-one;
8a-Ethyl-2-[5-methyl-2-[(1-methylsulfonylpiperidin-4-yl)amino]pyrimidin-4-yl]-7,8-dihydro-6H-thieno[2,3-a]pyrrolizin-4-one;
or a pharmaceutically acceptable salt thereof.