Patent ID: 11891455
Assignee: GALIMEDIX THERAPEUTICS INC
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 9:
10. The method of claim 9, wherein said compound (R)-2-[2-amino-3-(indol-3-yl)propionylamino]-2-methylpropionic acid of step (a) is prepared by the steps comprising
(a) reacting compound (2), with tert-butyl2-aminoisobutyrate (3) in the presence of 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholine chloride (DMTMM) to give compound (4), (b) removing the Boc group from compound 4 with hydrogen chloride gas to give compound (5); and, (c) providing a solution of compound (5) in water and adjusting the pH of the solution to about 5.5-5.7 to give compound (R)-2-[2-amino-3-(indol-3-yl)propionylamino]-2-methylpropionic acid.