Patent ID: 11891416
Assignee: INTERNATIONAL AIDS VACCINE INITIATIVE, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A  G | IPC A  C  G

Claim 0:
1. A recombinant vesicular stomatitis virus (VSV) vector comprising a gene encoding an N-terminally truncated form of a VSV surface glycoprotein G (VSV G) (G/Stem), wherein the gene comprises a polynucleotide encoding a polypeptide comprising:
a transmembrane domain of the VSV G;
a cytoplasmic tail of the VSV G; and
an ectodomain comprising a stem region of the VSV G,
wherein the ectodomain, and not the transmembrane domain, comprises one or more human immunodeficiency virus (HIV) epitope.