Patent ID: 11919908
Assignee: INCYTE CORPORATION
Field: Organic fine chemistry (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 29:
30. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein:
n is 1 or 2;
each R1 is independently selected from piperidinylmethyl, dimethylaminocarbonyl, N-morpholinylcarbonyl, and dimethylaminosulfonyl, wherein the piperidinylmethyl is optionally substituted by methylsulfonyl;
R2 is selected from C2-6 alkyl, C6-10 aryl, C3-10 cycloalkyl, 5-membered heteroaryl, 7-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10 aryl-C1-6 alkyl-, C3-10 cycloalkyl-C1-6 alkyl-, (5-10 membered heteroaryl)-C1-6 alkyl-, and (4-10 membered heterocycloalkyl)-C1-6 alkyl-, wherein the C2-6 alkyl, C6-10 aryl, C3-10 cycloalkyl, 5-membered heteroaryl, 7-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10 aryl-C1-6 alkyl-, C3-10 cycloalkyl-C1-6 alkyl-, (5-10 membered heteroaryl)-C1-6 alkyl-, and (4-10 membered heterocycloalkyl)-C1-6 alkyl- of R2 are each optionally substituted with 1, 2, 3, or 4 independently selected R2A substituents;
each R2A is independently selected from halo, C1-6 alkyl, C1-6 haloalkyl, 4-10 membered heterocycloalkyl, C6-10 aryl-C1-6 alkyl-, (4-10 membered heterocycloalkyl)-C1-6 alkyl-, CN, ORa21, C(O)NRc21Rd21, C(O)ORa21, and S(O)2Rb21, wherein the C1-6 alkyl, 4-10 membered heterocycloalkyl, C6-10 aryl-C1-6 alkyl-, and (4-10 membered heterocycloalkyl)-C1-6 alkyl- of R2A are each optionally substituted with 1, 2, 3, or 4 independently selected R2B substituents;
each Ra21, Rb21, Rc21, and Rd21 is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, and C2-6 alkynyl;
each R2B is independently selected from oxo, C1-6 alkyl, CN, ORa22, C(O)ORc22, and NRc22Rd22; and
each Ra22, Rc22, and Rd22 is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, and C2-6 alkynyl.