Patent ID: 11911447
Assignee: MEDERIS DIABETES LLC
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C  Y | IPC A  C

Claim 2:
3. The peptide of claim 1, having the structure of Formula III-B:, Formula III-B

(SEQ. ID. NO. 3)

His1-aa2-aa3-Gly4-Thr5-aa6-Thr7-Ser8-Asp9-aa10-

 

aa11-aa12-aa13-aa14-aa15-aa16-aa17-aa18-aal9-aa20-

 

aa21-aa22-aa23-aa24-aa25-aa26-aa27-aa28-aa29-aa30-

 

Z

wherein:
Z is OH or —NH-R3,
wherein R3 is selected from the group consisting of H, substituted or unsubstituted C1-C12 alkyl;

aa2 is Aib;
aa3 is Gln or Cit;
aa6 is Phe, 2FPhe, MePhe, 2FMePhe, or Nal2;
aa10 is Tyr, Nal2, Bip, or Bip2EtMeO;
aa11 is Ser, Asn, or Bip;
aa12 is Lys, Glu, or Ser;
aa13 is Tyr, Gln, or Cit;
aa14 is Leu, or Nle;
aa15 is Asp, or Glu;
aa16 is Ser, Gly, Glu, Ala, Aib, Lys, or Arg;
aa17 is Lys;
aa18 is Arg, hArg, Ala, Aib, Ac4c, or Ac5c;
aa19 is Ala, or Aib;
aa20 is Gln, Lys, Arg, Cit, Glu, or Aib;
aa21 is Asp, Glu, Leu, or Aib;
aa22 is Phe;
aa23 is Val, Ile, or Aib;
aa24 is Ala, or Gln;
aa25 is Trp;
aa26 is Leu;
aa27 is Leu;
aa28 is Gln;
aa29 is Thr, or Aib; and
aa30 is absent or is Arg;

wherein any two of aa1-aa23 are optionally cyclized through their side chains to form a lactam linkage.