Patent ID: 11964968
Assignee: ELI LILLY AND COMPANY
Field: Organic fine chemistry (Chemistry)
Classification: CPC C  A | IPC C

Claim 0:
1. A compound of the formula:, wherein
A is a five- or six-member aryl or heteroaryl;
each R1 is independently hydrogen, halogen, C1-C6 alkyl, C1-C6 heteroalkyl, —(C0-C4 alkyl)(C5-C6 heteroalkyl), —(C0-C4 alkyl)(C3-C7 cycloalkyl), —(C0-C4 heteroalkyl)(C3-C7 cycloalkyl), —(C0-C4 alkyl)(C4-C7 cycloheteroalkyl), —(C0-C4 heteroalkyl)(C3-C7 cycloheteroalkyl), —(C0-C4 alkyl)(C4-C10 bicyclic), —(C0-C4 alkyl)(C5-C6 aryl), —(C0-C4 alkyl)(C5-C6 heteroaryl), C4 alkyl)(C4-C10 heterobicyclic), C5-C12 spirane, C5-C12 heterospirane, adamantane, difluoromethylsulfane, or pentafluorosulfane, wherein each R1 is optionally substituted with one or more groups that are independently halogen, cyano, hydroxyl, oxo, methyl, methoxy, hydroxymethyl, ethyl, ethoxy, hydroxyethyl, methylamine, N,N-dimethylmethylamine, or mono-, di-, or tri-halomethyl, and wherein two R1 groups can fuse to form a ring structure that includes a portion of A and is optionally aromatic, and n is 1, 2, or 3;
X1, X2, X3, and X4 are each independently N, CH, C—CH3, C—CH2—OH, C—OCH3, C—CH2—OCH3, or C-halogen, wherein one of X1, X2, X3, and X4 is N; and
R2 is C1-C4 alkyl, —(C0-C4 alkyl)(C3-C7 cycloalkyl), —(C0-C4 alkyl)(C4-C7 heterocycloalkyl), or —(C0-C4 alkyl)(C4-C10 bicyclic) each optionally substituted with one or more groups that are independently deuterium, halogen, cyano, hydroxyl, oxo, methyl, methoxy, hydroxymethyl, ethyl, ethoxy, hydroxyethyl, cyclopropyl, or mono-, di-, or tri-halomethyl;
or a pharmaceutically acceptable salt thereof.