Patent ID: 11952574
Assignee: NOVO NORDISK A/S
Field: Biotechnology (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 7:
8. The RNAi oligonucleotide according to claim 7, wherein
the sense strand comprises 36 nucleotides and the antisense strand comprises 22 nucleotides, the nucleotides of each one of the strands being numbered 5′ to 3′;
all of positions 1-7, 12-27, and 31-36 of the sense strand and positions 1, 6, 8, 9, 11-13, and 15-22 of the antisense strand comprise a 2′-O-methyl (2′-OMe) modification; and
all of positions 8-11 of the sense strand and 2, 3, 4, 5, 7, 10 and 14 of the antisense strand comprise a 2′-fluoro (2′-F) modification.