Patent ID: 11883367
Assignee: JANSSEN PHARMACEUTICA NV
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 3:
4. The compound according to claim 1, wherein
R1 represents hydrogen;
R2 represents hydrogen;
Y represents —O— or —CH2—;
Z represents —X—CR5aR5b— or —CR5eR5g—CR5fR5h—;
and when Y represents —CH2—, then Z can also represent —CR5aR5b—X—;
R5a, R5b, R5e, R5f, R5g, and R5h represent hydrogen;
X represents —O—;
Ar represents, wherein Ar is optionally substituted in the position indicated by a with a substituent selected from the group consisting of —NH2, —NH—C1-4alkyl, and —NHR10d; and
wherein Ar is optionally substituted in the position indicated by β with a substituent selected from the group consisting of halo and CF3;
provided however that Ar is substituted in at least one of the positions indicated by α or β;
R10d represents C3-6cycloalkyl; C1-4alkyl substituted with one, two or three halo substituents; or C1-4alkyl substituted with one C3-6cycloalkyl substituent;
Het represents a bicyclic aromatic heterocyclic ring system selected from the group consisting of (a-1) and (a-4);
R3a and R3d each independently represent hydrogen, halo, —NR7aR7b, C1-4alkyl, or —O—C1-4alkyl;
R7a represents hydrogen;
R7b represents hydrogen or C1-4alkyl;
R4a, R4d and R4f each independently represent hydrogen or halo;
Q1 represents CR6a;
Q2 represents CR6b;
Q8 represents CR6g;
Q9 represents CR6h;
Q5 represents CR3d; Q6 represents N; and Q7 represents CR4f;
R6a, R6b, R6g, and R6h represent hydrogen.