Patent ID: 11958835
Assignee: KING FAISAL UNIVERSITY
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A  Y | IPC A  C

Claim 10:
11. A method of making the 6-(6-bromo-2-oxo-2H-chromen-3-yl)-4-(4-chlorophenyl)-2-alkoxynicotinonitrile compound of claim 1, the method comprising:
adding a mixture of 3-acetyl-2H-1-benzopyran-2-one, 6-bromo-3-(3-(4-chlorophenyl)prop-2-enoyl)-2H-1-benzopyran-2-one, and malononitrile to a solution of a sodium alkoxide in an absolute alcohol with stirring to obtain a reaction mixture;
irradiating the reaction mixture followed by cooling to room temperature to obtain a crude product;
purifying the crude product by filtering and recrystallization using the absolute alcohol; and
obtaining the 6-(6-bromo-2-oxo-2H-chromen-3-yl)-4-(4-chlorophenyl)-2-alkoxynicotinonitrile compound.