Patent ID: 11872371
Assignee: THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
Field: Medical technology (Instruments)
Classification: CPC A | IPC A

Claim 6:
7. A method for diagnosing or treating or monitoring symptoms in a subject with a cytokine-mediated disease or disorder based on the subject's vagus nerve activity, comprising a calibration phase and a real-time diagnostic, treatment or monitoring phase, wherein the calibration phase precedes the real-time diagnostic, treatment or monitoring phase, and wherein
the calibration phase comprises correlating a plurality of vagus nerve activity measurements from a chronically implanted recording electrode in the subject with a plurality of concurrent measurements of levels of one or more cytokines in the blood of the subject to obtain a functional relationship between blood cytokine levels and vagus nerve activity recorded from the chronically implanted recording electrode in the subject, wherein the blood cytokine measurements during the calibration phase consist of one or more of blood cytokine levels that fluctuate naturally in the subject and blood cytokine levels that occur in response to administration of one or more of a cytokine and a cytokine antagonist or inhibitor to the subject; and
the real-time diagnostic, treatment or monitoring phase comprises analyzing the subject's real-time vagus nerve activity in accordance with the previously obtained functional relationship between blood cytokine levels and vagus nerve activity to initiate a treatment method, wherein the treatment method consists of one or more of administering a cytokine antagonist or inhibitor to the subject and applying acoustic energy stimulus to the subject;
wherein the disease or disorder is one or more of type 1 diabetes, type 2 diabetes, obesity, trauma, hemorrhagic shock, ischemia-reperfusion injury, colitis, sepsis, pancreatitis, myasthenia gravis, multiple sclerosis, systemic lupus erythematosus, autoimmune thyroiditis (Hashimoto's thyroiditis), Graves' disease, autoimmune uveoretinitis, polymyositis, fever, and swelling.