Patent ID: 11967090
Assignee: ABBERIOR INSTRUMENTS GMBH
Field: Optics (Instruments)
Classification: CPC G | IPC G

Claim 0:
1. A method of detecting movements of a sample with respect to an objective, the method comprising
imaging the sample onto an image sensor which comprises an array of pixels by means of the objective;
in a set-up period
registering light coming from the sample at the pixels of the image sensor;
determining temporal variations of intensities of the light coming from the sample and registered at the individual pixels of the image sensor during the set-up period in that a temporal course of the intensity of the light, which has been registered at each respective one of the individual pixels of the image sensor over the set-up period, such that each pixel of the image sensor is analyzed separately;
selecting a subset of not more than 90% of the pixels of the image sensor using the temporal variation of each of the pixels of the image sensor as a criterion;

after the set-up period
recording images of the sample by the image sensor in that light coming from the sample is registered at the pixels of the image sensor; and
comparing parts of the images that each correspond to the selected subset of the pixels of the image sensor to parts of at least one reference image that also correspond to the subset of the pixels of the image sensor to detect undesired movements of the sample with respect to the objective.