Patent ID: 11867693
Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Field: Measurement (Instruments)
Classification: CPC G  B | IPC B  G

Claim 1:
2. The lateral flow device of claim 1, wherein said device further comprises a third test line (T3), said third test line comprising binding moieties that bind a complex formed between beta-trace protein (βTP) and an indicator attached to a βTP binding molecule, wherein when a nasal drip sample diluted 300 fold with phosphate buffered saline is applied to said device:
said first test line (T1) said second test line (T2) and said third test line (T3) are configured so that a signal is detectable at said first test line and said second test line, but not at said third test line when βTP concentration in a sample applied to said device is greater than the βTP level indicative of no CSF leak and less than a βTP level definitive of the presence of a CSF leak; and
a signal is detectable at all three test lines T1, T2, and T3 when βTP concentration in a sample applied to said device is equal to or greater than a βTP level definitive of the presence of a CSF leak.