Patent ID: 11958839
Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
Field: Organic fine chemistry (Chemistry)
Classification: CPC C | IPC C

Claim 24:
25. A method of treatment of a neurodegenerative disorder chosen from Alzheimer's disease, Lewy body dementia, fronto-temporal dementia, amyotrophic lateral sclerosis, multiple sclerosis, Parkinson's disease, HIV-induced neuroinflammation, essential tremors, and Charcot-Marie-Tooth neuropathy comprising the administration of a therapeutically effective amount of a compound of the following formula (I), or a stereoisomer thereof, or a salt thereof, to a subject in need thereof, wherein:
n is an integer between 1 and 4, forming a 6-10-membered cycloalkyl;
A is chosen from phenyl and heteroaryl, optionally substituted with one or more C1-C3 alkyl substituents;
R1 is chosen from hydrogen and C1-C3 alkyl;
R2 and R3 are joined together via a group Y, wherein R2—Y—R3, together with the carbon to which R2 and R3 attach, forms C3-C6 cycloalkyl or C3-C6 heterocycloalkyl, either of which is optionally substituted with one or more substituents chosen from hydroxyl, fluorine, and methyl; or the C3-C6 cycloalkyl or C3-C6 heterocycloalkyl is fused with a phenyl ring which is optionally substituted with one or more substituents chosen from hydroxyl, halogen, and C1-C6 alkyl;
Y is chosen from C and O;
R4 is chosen from, R5 and R6 are each independently C1-C6 alkyl;
R7, R8, R9, and R10 are independently chosen from hydrogen and hydroxyl, or is independently chosen from C1-C6 alkyl and C1-C6 alkyloxy, either of which is optionally substituted with methoxy;
p is 1 or 2; and
X is chosen from C, O, or NR11 where R11 is hydrogen or C1-C3 alkyl:
with the proviso that if A is thiophene, n is 2 or 3, R1 is hydrogen, and R4 is, , then R5 and R6 are not both methyl.