Patent ID: 11891402
Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A  G | IPC A  C

Claim 6:
7. The human K-Ras protein of claim 3, wherein L1 is a substituted or unsubstituted pyrazolylene, wherein the substituents are independently selected from halogen, —CXc3, —CN, —SO2Cl, —SOn3R10c, —SOv3NR7cR8c, —NHNH2, —ONR7CR8c, —NHC═(O)NHNH2, —NHC═(O)NR7cR8c, —N(O)m3, —NR7cR8c, —C(O)R9c, —C(O) OR9c, —C(O)NR7cR8c, —OR10c, —NR7cSO2R10c, —NR7cC═(O)R9c, —NR7cC(O) OR9c, —NR7cOR9c, —OCXc3, OCHXc2, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
two adjacent substituents may optionally be joined to form a substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
R7c, R8c, R9c and R10c are independently hydrogen, halogen, —CF3, —CN, —OH, —NH2, —COH, —CONH2, —NO2, —SH, —SO2Cl, —SO3H, —SO4H, —SO2NH2, —NHNH2, —ONH2, —NHC═(O)NHNH2, —NHC═(O)NH2, —NHSO2H, —NHC═(O)H, —NHC(O)—OH, —NHOH, —OCF3, —OCHF2, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
R7c and R8c substituents bonded to the same nitrogen atom may optionally be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl;
m3 and v3 are independently an integer from 1 to 2;
n3 is an integer from 0 to 4;
and Xc is independently —Cl, —Br, —I, or —F.