Patent ID: 11862297
Assignee: IQVIA INC.
Field: Computer technology (Electrical engineering)
Classification: CPC G | IPC G

Claim 20:
21. A non-transitory computer-readable storage device encoded with computer program instructions that, when executed by one or more computers, cause the one or more computers to perform operations comprising:
accessing, by the one or more computers, encrypted genomic data from a first cohort and a second cohort of patients, wherein the genomic data for each patient includes chromosome location information that is structured with a probabilistic and irreversible hash and genomic sequence information that is structured with a deterministic and reversible hash, and wherein a phenotypic trait is present in the second cohort but absent from the first cohort;
generating location bins, by the one or more computers, based on the probabilistic and irreversible hash that projects the chromosome location information from the first and second cohorts of patients into reduced dimensions, wherein genomic variants located near one another belong to a particular location bin;
identifying, by the one or more computers and based on the location bins and a comparison of the genomic data and a reference genome, one or more genomic variants in the particular location bin, wherein the one or more genomic variants represent variations from the reference genome;
comparing, by the one or more computers, a first number of genomic variants in the particular location bin for the first cohort of patients with a second number of genomic variants in the particular location bin for the second cohort of patients, wherein a difference between the first number and the second number is associated with the phenotypic trait;
determining, by the one or more computers, that the first number of genomic variants and the second number of genomic variants differ by more than a threshold value in the particular location bin; and
providing, by the one or more computers and for downstream genomic analysis, information indicative of the genomic variants in the particular location bin.