Patent ID: 11920128
Assignee: KYMAB LIMITED
Field: Biotechnology (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 15:
16. The method of claim 1, wherein when the incoming nucleic acid is injected into the non-human mammal zygote, the insert nucleic acid
(a) replaces a target sequence in whole or in part at the endogenous location of the target gene at the genomic locus of interest, wherein the insert nucleic acid comprises all or part of one or more human antibody gene segments or encodes all or part of a human protein, a human protein subunit or domain, a human antibody variable region, or a human antibody constant region; and/or
(b) replaces an orthologous or homologous sequence in the genome, wherein the insert nucleic acid comprises all or part of one or more human antibody gene segments or encodes all or part of a human protein, a human protein subunit or domain, a human antibody variable region, or a human antibody constant region.