Patent ID: 11896674
Assignee: SUZHOU RIBO LIFE SCIENCE CO., LTD.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 16:
17. The siRNA conjugate according to claim 1, wherein in the siRNA, at least one phosphate group is a phosphorothioate group, and at least one linkage selected from the group consisting of the following inter-nucleotide linkages is a phosphorothioate linkage:
the linkage between the first and second nucleotides at 5′ terminal of the sense strand;
the linkage between the second and third nucleotides at 5′ terminal of the sense strand;
the linkage between the first and second nucleotides at 3′ terminal of the sense strand;
the linkage between the second and third nucleotides at 3′ terminal of the sense strand;
the linkage between the first and second nucleotides at 5′ terminal of the antisense strand;
the linkage between the second and third nucleotides at 5′ terminal of the antisense strand;
the linkage between the first and second nucleotides at 3′ terminal of the antisense strand; and
the linkage between the second and third nucleotides at 3′ terminal of the antisense strand.