Patent ID: 11931362
Assignee: CIPLA LIMITED
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 0:
1. A long term storage multi-dose ready-to-dilute or ready-to-use pharmaceutical liquid formulation comprising: a) pemetrexed or a pharmaceutically acceptable salt thereof, b) an antioxidant; c) a preservative; d) a buffering agent, which is present in an amount in the range of about 0.5 mg/mL to 30 mg/mL; and e) a pharmaceutically acceptable fluid, wherein the formulation when stored for six months in a sealed, sterile vial at 25° C./60% RH and 40° C./75% RH contains no more than 1.0% total impurity as measured by HPLC, wherein the antioxidant is selected from the group consisting of: monothioglycerol, L-cysteine and thioglycolic acid, acetyl cysteine, butylated hydroxy toluene, butylated hydroxy anisole, DL-tocopherol, sodium metabisulfite, sodium formaldehyde sulfoxylate, EDTA and its derivatives, ascorbic acid, citric acid and its pharmaceutically acceptable salts, sodium sulfite and its derivative, and combinations thereof.