Patent ID: 11866700
Assignee: EXICURE OPERATING COMPANY
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 9:
10. A method for treating a disorder, comprising:
administering to a subject having a disorder a multiplex antisense oligonucleotide spherical nucleic acid (mASO-SNA), comprising a core having an oligonucleotide shell comprised of an antisense oligonucleotide 10 to 30 linked nucleosides in length targeted to a first gene and an antisense oligonucleotide 10 to 30 linked nucleosides in length targeted to a second gene, wherein the core is a liposome core and the oligonucleotide shell is positioned on the exterior of the core in an effective amount to treat the disorder,
wherein each antisense oligonucleotide comprises at least two modified nucleosides,
wherein each antisense oligonucleotide further comprises a molecular species at the 5′ end, 3′ end, or 5′ and 3′ end of the antisense oligonucleotide,
wherein the molecular species is a lipid moiety connected to the antisense oligonucleotide by a linker, wherein the linker comprises hexaethylene glycol.