Patent ID: 11866430
Assignee: BRISTOL-MYERS SQUIBB COMPANY
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 1:
2. The compound according to claim 1 or a salt thereof,
R1 is H, Cl, Br, —CN, C1-3 alkyl, C2-3 alkenyl, C1-2 alkoxy, —C(O)OH, —C(O)O(C1-2 alkyl), —C(O)NRaRa, —NRaRa, or —NRaC(O)O(C1-4 alkyl);
R2 is C1-4 alkyl, C1-3 cyanoalkyl, C1-3 fluoroalkyl, C2-3 alkenyl, —CH2CH2CH═CF2, C3-4 alkynyl, —(CH2)1-3OCH3, —(CH2)1-3O(CH2)1-2OCH3, —(CH2)1-3C(O)CH3, —(CH2)1-3C(O)O(C1-2 alkyl), —(CH2)1-2Rb, —(CH2)1-3ORb, or —(CH2)1-3OCH2Rb;
Rb is C3-6 cycloalkyl or dioxanyl, each substituted with zero to 1 substituent selected from F, —CN, —CH3, and —OCH3;
R3 is H, F, Cl, Br, —CN, C1-2 alkyl, C1-2 fluoroalkyl, —NO2, —C(O)O(C1-2 alkyl), or —C(O)(C1-2 fluoroalkyl);
R4 is:
(a) 2,3-dihydro-1H-indenyl substituted with zero to 2 substituents independently selected from F, Cl, —OH, —CH3, —CF3, —OCH3, and —OCH2CH═CH2; or
(b) —CH2Ry, —C(CH3)2Ry, —CHRxRy, —CH2CH(OH)Rx, —CH(CH3)(CH2CH2OCH3), or cyclopropyl substituted with fluorophenyl;
Rx is C1-5 alkyl, C1-2 hydroxyalkyl, C1-2 aminoalkyl, C3-6 cycloalkyl, or phenyl substituted with zero to 2 substituents independently selected from F, Cl, —OH, C1-2 alkyl, —CHF2, —OCH3, —OCH2CH═CH2, and —OCH2C≡CH; and
Ry is 1,3-benzodiazolyl, indazolyl, indolyl, indolinyl, naphthalenyl, oxoindolinyl, pyridinyl, pyrimidinyl, or phenyl, each substituted with zero to 3 substituents independently selected from F, Cl, Br, —OH, —CN, C1-4 alkyl, C1-2 fluoroalkyl, C1-2 alkoxy, C1-2 fluoroalkoxy, —OCH2CH═CH2, —OCH2C≡CH, —OCH2(cyanopyridinyl), —NRcRc, —NHS(O)2CH3, —NHC(O)(C1-2 alkyl), —NHC(O)O(C1-4 alkyl), —NHC(O)(phenyl), —NHC(O)NH(phenyl), and phenyl.