Patent ID: 11926666
Assignee: AMGEN RESEARCH (MUNICH) GMBH
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 17:
18. The method of claim 1, wherein the second binding domain comprises a VH region and a VL region selected from the group consisting of:
a) a VH region comprising a CDR-H1 comprising the amino acid sequence of SEQ ID NO: 448, a CDR-H2 comprising the amino acid sequence of SEQ ID NO: 449, and a CDR-H3 comprising the amino acid sequence of SEQ ID NO: 450, and a VL region comprising a CDR-L1 comprising the amino acid sequence of SEQ ID NO: 445, a CDR-L2 comprising the amino acid sequence of SEQ ID NO: 446, and a CDR-L3 comprising the amino acid sequence of SEQ ID NO: 447;
b) a VH region comprising a CDR-H1 comprising the amino acid sequence of SEQ ID NO: 457, a CDR-H2 comprising the amino acid sequence of SEQ ID NO: 458, and a CDR-H3 comprising the amino acid sequence of SEQ ID NO: 459, and a VL region comprising a CDR-L1 comprising the amino acid sequence of SEQ ID NO: 454, a CDR-L2 comprising the amino acid sequence of SEQ ID NO: 455, and a CDR-L3 comprising the amino acid sequence of SEQ ID NO: 456;
c) a VH region comprising a CDR-H1 comprising the amino acid sequence of SEQ ID NO: 466, a CDR-H2 comprising the amino acid sequence of SEQ ID NO: 467, and a CDR-H3 comprising the amino acid sequence of SEQ ID NO: 468, and a VL region comprising a CDR-L1 comprising the amino acid sequence of SEQ ID NO: 463, a CDR-L2 comprising the amino acid sequence of SEQ ID NO: 464, and a CDR-L3 comprising the amino acid sequence of SEQ ID NO: 465;
d) a VH region comprising a CDR-H1 comprising the amino acid sequence of SEQ ID NO: 475, a CDR-H2 comprising the amino acid sequence of SEQ ID NO: 476, and a CDR-H3 comprising the amino acid sequence of SEQ ID NO: 477, and a VL region comprising a CDR-L1 comprising the amino acid sequence of SEQ ID NO: 472, a CDR-L2 comprising the amino acid sequence of SEQ ID NO: 473, and a CDR-L3 comprising the amino acid sequence of SEQ ID NO: 474;
e) a VH region comprising a CDR-H1 comprising the amino acid sequence of SEQ ID NO: 484, a CDR-H2 comprising the amino acid sequence of SEQ ID NO: 485, and a CDR-H3 comprising the amino acid sequence of SEQ ID NO: 486, and a VL region comprising a CDR-L1 comprising the amino acid sequence of SEQ ID NO: 481, a CDR-L2 comprising the amino acid sequence of SEQ ID NO: 482, and a CDR-L3 comprising the amino acid sequence of SEQ ID NO: 483;
f) a VH region comprising a CDR-H1 comprising the amino acid sequence of SEQ ID NO: 493, a CDR-H2 comprising the amino acid sequence of SEQ ID NO: 494, and a CDR-H3 comprising the amino acid sequence of SEQ ID NO: 495, and a VL region comprising a CDR-L1 comprising the amino acid sequence of SEQ ID NO: 490, a CDR-L2 comprising the amino acid sequence of SEQ ID NO: 491, and a CDR-L3 comprising the amino acid sequence of SEQ ID NO: 492;
g) a VH region comprising a CDR-H1 comprising the amino acid sequence of SEQ ID NO: 502, a CDR-H2 comprising the amino acid sequence of SEQ ID NO: 503, and a CDR-H3 comprising the amino acid sequence of SEQ ID NO: 504, and a VL region comprising a CDR-L1 comprising the amino acid sequence of SEQ ID NO: 499, a CDR-L2 comprising the amino acid sequence of SEQ ID NO: 500, and a CDR-L3 comprising the amino acid sequence of SEQ ID NO: 501;
h) a VH region comprising a CDR-H1 comprising the amino acid sequence of SEQ ID NO: 511, a CDR-H2 comprising the amino acid sequence of SEQ ID NO: 512, and a CDR-H3 comprising the amino acid sequence of SEQ ID NO: 513, and a VL region comprising a CDR-L1 comprising the amino acid sequence of SEQ ID NO: 508, a CDR-L2 comprising the amino acid sequence of SEQ ID NO: 509, and a CDR-L3 comprising the amino acid sequence of SEQ ID NO: 510;
i) a VH region comprising a CDR-H1 comprising the amino acid sequence of SEQ ID NO: 520, a CDR-H2 comprising the amino acid sequence of SEQ ID NO: 521, and a CDR-H3 comprising the amino acid sequence of SEQ ID NO: 522, and a VL region comprising a CDR-L1 comprising the amino acid sequence of SEQ ID NO: 517, a CDR-L2 comprising the amino acid sequence of SEQ ID NO: 518, and a CDR-L3 comprising the amino acid sequence of SEQ ID NO: 519; and
j) a VH region comprising a CDR-H1 comprising the amino acid sequence of SEQ ID NO: 529, a CDR-H2 comprising the amino acid sequence of SEQ ID NO: 530, and a CDR-H3 comprising the amino acid sequence of SEQ ID NO: 531, and a VL region comprising a CDR-L1 comprising the amino acid sequence of SEQ ID NO: 526, a CDR-L2 comprising the amino acid sequence of SEQ ID NO: 527, and a CDR-L3 comprising the amino acid sequence of SEQ ID NO: 528.