Patent ID: 11926616
Assignee: INCYTE CORPORATION
Field: Organic fine chemistry (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 12:
13. The method of claim 1, wherein:
X1 is N;
R2 is C(O)NRc1Rd1;
Rc1 is H;
Rd1 is selected from ethyl, propyl, isopropyl, butyl, tert-butyl, cyclobutyl, cyclohexyl, bicyclo[1.1.1]pentanyl, bicyclo[2.1.1]hexanyl, bicyclo[2.2.1]heptanyl, methyl-cyclopropyl, methyl-cyclobutyl, methyl-phenyl, ethyl-phenyl, oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, pyrrolidinyl, and thianyl, wherein the ethyl, propyl, isopropyl, tert-butyl, cyclobutyl, cyclohexyl, bicyclo[1.1.1]pentanyl, bicyclo[2.1.1]hexanyl, bicyclo[2.2.1]heptanyl, methyl-cyclopropyl, methyl-cyclobutyl, methyl-phenyl, ethyl-phenyl, oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, pyrrolidinyl, and thianyl of Rd1 is optionally substituted with 1 or 2 independently selected RA substituents;
or, any Rc1 and Rd1, attached to the same N atom, together with the N atom to which they are attached, form an azetidinyl or pyrrolidinyl, wherein the azetidinyl or pyrrolidinyl is optionally substituted with 1 or 2 independently selected RA substituents;
each RA is independently selected from oxo, methyl, CH2F, CHF2, CF3, —OCH3, —CH2OH, CN, and OH;
R3 is selected from H, methyl, and CD3;
R4 and R5 are each H;
R6 is selected from CH2F, CHF2 and CF3; and
R7 and R8 are each H.