Patent ID: 11919961
Assignee: CELLECTIS
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 12:
13. The method of claim 1, wherein expression of at least one gene encoding an immune checkpoint protein is reduced or suppressed in the T cell, wherein the checkpoint protein is selected from the group consisting of: CTLA4, PPP2CA, PPP2CB, PTPN6, PTPN22, PDCD1, LAG3, HAVCR2, BTLA, CD160, TIGIT, CD96, CRTAM, LAIR1, SIGLEC7, SIGLEC9, CD244, TNFRSF1OB, TNFRSF1OA, CASP8, CASP10, CASP3, CASP6, CASP7, FADD, FAS, TGFBRII, TGFBRI, SMAD2, SMAD3, SMAD4, SMAD10, SKI, SKIL, TGIF1, IL1ORA, IL1ORB, HMOX2, IL6R, IL6ST, CSK, PAG1, SIT1, FOXP3, PRDM1_(or blimp1), BATF, GUCY1A2, GUCY1A3, GUCY1B2, and GUCY1B3.