Patent ID: 11926648
Assignee: IMPERIAL COLLEGE INNOVATIONS LIMITED
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A  G  Y | IPC A  C  G

Claim 4:
5. The composition of claim 1 wherein the EDE comprises a region centred in a valley lined by the h strand on the domain II side, and the “150 loop” on the domain I side (across from the dimer interface), wherein the 150 loop spans residues 148-159, connecting b-strands E0 and F0 of domain 1, and carries the N153 glycan, which covers the fusion loop of the partner subunit in the dimer, optionally wherein the region comprises the h strand (residues 67-74 which bear the N67 glycan), the fusion loop and residues immediately upstream (residues 97-106) and the ij loop (residues 246-249) of the reference subunit, wherein the reference subunit is the subunit which contributes the fusion loop,
optionally wherein the EDE further comprises the 150 loop and the N153 glycan chain of the second subunit,
optionally wherein one or both regions is in a similar spatial configuration as the native region;
or wherein the EDE comprises the Zika PF13 beta strand b of domain IL bed beta-sheet edge, fusion loop main chain, fusion loop R99 side chain, Q77 side chain, disulphide bond between C74 and C105; beta strand E, K373, charged residues in domain I, kl loop of domain II, or regions corresponding thereto.