Patent ID: 11897970
Assignee: THE UNIVERSITY OF LIVERPOOL
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A compound of formula IA,, or a pharmaceutically-acceptable salt, solvate or clathrate thereof, wherein:
R1 represents H, C1-6 alkyl, C1-6 acyl, benzyl or benzoyl;
AA1, AA2 and AA5 to AA7 each independently represents a proteinogenic or non-proteinogenic amino acid;
AA3 and AA4 each independently represents a proteinogenic or non-proteinogenic amino acid, diaminopropanoic acid, diaminobutanoic acid, or ornithine;
R8 represents hydrogen or C1-4 alkyl;
R9a, represents a proteinogenic or non-proteinogenic amino acid side chain, —CH2—NH2, —(CH2)2—NH2 or —(CH2)3—NH2;
R10a represents a side chain of an amino acid selected from the group consisting of valine, isoleucine, leucine, methionine, phenylalanine, tyrosine and tryptophan, a hydrophobic non-proteinogenic amino acid side chain, hydrogen, or R10a is linked to the adjacent nitrogen atom to form a proline ring;
R11a represents a proteinogenic or non-proteinogenic amino acid side chain;
Z is —O— or —NH—;
optionally wherein the compound of formula IA is covalently bonded to a delivery agent, which is either capable of covalently bonding to one or more structures on a bacterial cell membrane or comprises a hydrophilic portion capable of otherwise binding to one or more structures on a bacterial cell membrane.