Patent ID: 11970497
Assignee: NOVARTIS AG
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A compound of formula (I):, or a pharmaceutically acceptable salt thereof,
wherein:
 is a single bond or a double bond;
Z is either OH, when  is a single bond; or O,  when is a double bond;
each R1 is fluoro;
R2a and R2b are each independently;
each R3 is independently selected from the group consisting of H and D;
R4 is selected from the group consisting of aryl, a 5 to 6-membered heteroaryl comprising 1, 2, or 3, heteroatoms independently selected from N, O, and S; and a 9 to 10-membered fused bicyclic heteroaryl comprising 1, 2, or 3, heteroatoms independently selected from N and O; wherein any of the foregoing is optionally substituted with one or more R6;
R5 is selected from the group consisting of H; (C1-C6)alkyl; (C2-C6)alkenyl; (C0-C4)alkylOR8;
each R6 is independently selected from the group consisting of halo; (C1-C6)alkyl; (C1-C6)alkoxy; halo(C1-C6)alkyl; OH; aryl; 3 to 6-membered heterocycle; 5- to 6-membered heteroaryl; (C0-C4)alkylS(O)m(C1-C6)alkyl; halo(C1-C6)alkoxy; (C0-C4)alkylS(O)mN(R8)2; (C0-C4)alkyl N(R8)2; (C0-C4)alkyl(CO)OR7; N(R8)S(O)m(C1-C6)alkyl; N(R8)S(O)m(C3-C6)cycloalkyl; OP(O)(OH)2; (C0-C3)alkyl(CO)NHR11; (C0-C3)alkylOR7, and (C3-C10)cycloalkyl; wherein each R6, when not being halo, OH, or OP(O)(OH)2, is optionally substituted with one to three R9; or two neighboring R6, together with the atoms to which they attach form a 5 to 7-membered heterocycle or (C5-C8)cycloalkyl;
each R7 and R8 is independently selected from the group consisting of H or (C1-C6)alkyl, that is optionally substituted with one to three R9;
each R9 is independently selected from the group consisting of halo; —OH; amino, (C1-C4)alkylamino, di(C1-C4)alkylamino, OP(O)(OH)2;(C1-C6)alkyl; (C1-C3)alkynyl; (C1-C6)alkoxy; halo(C1-C6)alkyl; (C0-C4)alkylS(O)m(C1-C6)alkyl; halo(C1-C6)alkoxy; 3 to 6-membered heterocycle which is optionally substituted with oxo (═O); (C0-C4)alkylS(O)mN(R10)2; (C0-C4)alkyl(CO)R10; (C0-C4)alkyl(CO)OR10; (C0-C4)alkylNR10S(O)m(C1-C6)alkyl; (C0-C4)alkylOR10; (C0-C4)alkylN(R10)2; (C0-C4)alkylCN; (C0-C4)alkylN(R10)2; and (C0-C4)alkyl(CO)N(R10)2;
each R10 is independently selected from the group consisting of H, (C1-C6)alkyl; or 3 to 6-membered heterocycle, wherein the 3 to 6-membered heterocycle is optionally substituted with one or more of (C1-C6)alkyl; and oxo (═O);
each R11 is selected from the group consisting of H; 4 to 6-membered heterocycle which is optionally substituted with one to four R12; (C3-C6)cycloalkyl which is optionally substituted with one to four R12; (C0-C3)alkyl(C3-C6)cycloalkyl (C1-C3)alkyl which is optionally substituted with halo; CH2-aryl which is optionally substituted with one to three R12; (C1-C6)alkyl; (C2-C6)alkenyl; or (C2-C6)alkynyl, wherein each of the (C1-C6)alkyl; (C2-C6)alkenyl; and (C2-C6)alkynyl is optionally substituted with one or more R13;
each R12 is independently selected from the group consisting of OH, (C1-C3)alkoxy, NH2; or (C1-C3)alkyl optionally substituted with one or more OH;
each R13 is independently selected from the group consisting of halo, OH, amino, (C1-C4)alkylamino, di(C1-C4)alkylamino, (C1-C3)alkoxy; and C(O)—(C3-C8)cycloalkyl;
m is 0, 1, or 2; and
n is 1.