Patent ID: 11952422
Assignee: CHUGAI SEIYAKU KABUSHIKI KAISHA
Field: Biotechnology (Chemistry)
Classification: CPC C | IPC C

Claim 0:
1. A tri-specific IgG antibody comprising:
a dual-binding Fab comprising a first variable region that binds to human CD3 epsilon and human CD137, but does not bind to human CD3 epsilon and human CD137 at the same time;
a second Fab comprising a second variable region that binds to a third antigen different from human CD3 epsilon and human CD137, wherein the third antigen is a cancer antigen; and
an Fc region,
wherein the first variable region comprises a heavy chain variable domain (VH) and a light chain variable domain (VL) selected from the VH and VL of (a) to (e) below:
(a) a VH comprising the amino acid sequence of SEQ ID NO: 30 and a VL comprising the amino acid sequence of SEQ ID NO: 51,
(b) a VH comprising the amino acid sequence of SEQ ID NO: 46 and a VL comprising the amino acid sequence of SEQ ID NO: 53,
(c) a VH comprising the amino acid sequence of SEQ ID NO: 40 and a VL comprising the amino acid sequence of SEQ ID NO: 56,
(d) a VH comprising the amino acid sequence of SEQ ID NO: 30 and a VL comprising the amino acid sequence of SEQ ID NO: 58, and
(e) a VH comprising the amino acid sequence of SEQ ID NO: 40 and a VL comprising the amino acid sequence of SEQ ID NO: 61.