Patent ID: 11879133
Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 11:
12. A method of treating optic neuropathy in a subject in need thereof, the method comprising delivery of a recombinant AAV to an eye of the subject, the recombinant AAV comprising an AAV capsid, and a vector genome packaged therein, the vector genome comprising:
(a) an AAV5′ ITR sequence;
(b) a promoter sequence;
(c) a sequence encoding human SIRT1; and
(d) an AAV3′ ITR sequence,
wherein the sequence encoding human SIRT1 comprises SEQ ID NO: 12 and is operably linked to the promoter sequence, and
wherein delivery of the recombinant AAV results in transduction and preservation of retinal ganglions cells in the eye to treat optic neuropathy.