Patent ID: 11969527
Assignee: BIOSAPIEN INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  B | IPC A

Claim 0:
1. A method of decreasing growth rate of a tumor having colorectal cancer cells in a subject, the method comprising implanting a biomaterial to a target site in the subject, wherein the target site comprises the tumor, wherein the tumor comprises the colorectal cancer cells, wherein the biomaterial comprises a first plurality of geometric elements and a therapeutically-effective amount of a therapeutic agent, wherein the therapeutic agent is 5-fluorouracil,
wherein, upon the implanting, the therapeutically-effective amount of the therapeutic agent is released from the biomaterial at the target site, to effect a decrease in the growth rate of the tumor; and
wherein:
a first geometric element of the first plurality of geometric elements is formed by a first porous border, wherein the first porous border comprises a polymer and the therapeutic agent;
a second geometric element of the first plurality of geometric elements is formed by a non-porous border and a first solid region comprising the polymer, wherein the therapeutic agent cannot diffuse into the second geometric element from the first porous border;
the first solid region is adjacent to and within the non-porous border; and
a portion of the first porous border is adjacent to a portion of the non-porous border.