Patent ID: 11872217
Assignee: CHEMOCENTRYX, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C  Y | IPC A  C

Claim 3:
4. A compound of Formula (I),, or a pharmaceutically acceptable salt, solvate, or hydrate thereof, wherein:
R3 and R3′ are each independently selected from the group consisting of —NRdRe and 4- to 9-membered monocyclic or spirocyclic non-aromatic heterocyclic rings, wherein the 4- to 9-membered monocyclic or spirocyclic non-aromatic heterocyclic rings contain from 1 to 3 N heteroatoms and are optionally substituted with from 1 to 2 substituents independently selected from the group consisting of oxo, —OH, and C1-8 alkyl;
Rd is selected from the group consisting of H and C1-8 alkyl;
Re is selected from H, —C1-8 alkyl, —X2—CONHSO2—C1-8 alkyl, C3-10 cycloalkyl, C4-8 heterocyclyl, and —X2—C4-8 heterocyclyl, wherein the alkyl or alkylene portions of Re are optionally further substituted with from 1 to 2 substituents independently selected from OH, COOH, CONH2, and COO—C1-8 alkyl, and the C4-8 heterocyclyl and C3-10 cycloalkyl portions of Re are optionally substituted with 1 substituent independently selected from OH and oxo;
X2 is a C1-6 alkylene and is optionally further substituted with OH; and
R4 and R4′ are each independently selected from the group consisting of —O-ethyl, —O—CH2-pyridyl optionally substituted with 1 —CN, and —O—CH2-phenyl optionally substituted with 2 —CN.