Patent ID: 11957664
Assignee: UNIVERSITY OF VIRGINIA PATENT FOUNDATION
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C  G | IPC A  C  G

Claim 0:
1. A method of treating an addictive disease or disorder, comprising:
administering to a patient in need thereof a therapeutically effective amount of ondansetron, wherein the patient's HTR3A gene, HTR3B gene, and/or serotonin transporter gene SLC6A4 is known to have a genotype selected from sets (a)-(f):
a. the TT genotype of rs1042173 of gene SLC6A4 and the AG genotype of rs1150226 of gene HTR3A;
b. the TT genotype of rs1042173 of gene SLC6A4 and the AC genotype of rs17614942 of gene HTR3B;
c. the TT genotype of rs1042173 of gene SLC6A4, the AG genotype of rs1150226 of gene HTR3A, and the AC genotype of rs17614942 of gene HTR3B;
d. the TT genotype of rs1042173 of gene SLC6A4 and the GG genotype of rs1176713 of gene HTR3A;
e. the TT genotype of rs1042173 of gene SLC6A4, the GG genotype of rs1176713 of gene HTR3A, and the AG genotype of rs1150226 of gene HTR3A; and,
f. the TT genotype of rs1042173 of gene SLC6A4, the GG genotype of rs1176713 of gene HTR3A, and the AC genotype of rs17614942 of gene HTR3B];
wherein the addictive disease or disorder is selected from the group consisting of: alcohol-related diseases and disorders and opioid-related disorders.