Patent ID: 11883820
Assignee: APPLIED CELLS INC.
Field: Measurement (Instruments)
Classification: CPC B  A  C  G | IPC A  B  C  G

Claim 0:
1. A device for separating biological entities from a sample fluid, the device comprising:
a substrate including:
a linear channel having a wide section with a first constant width, a narrow section with a second constant width, and a tapered transition section connecting a downstream end of said wide section to an upstream end of said narrow section;
a first inlet connected to an upstream end of said wide section for introducing a buffer fluid into said linear channel;
a first outlet connected to a downstream end of said narrow section;
a second inlet for introducing said sample fluid into said wide section;
a first pair of side channels connecting said second inlet to said upstream end of said wide section;
a second outlet; and
a second pair of side channels connecting said second outlet to said downstream end of said narrow section; and

a means for generating ultrasound in a form of a standing wave in said sample and buffer fluids in said wide and narrow sections to separate said biological entities by size,
wherein said first constant width is a first integer multiple of one-half wavelength of said standing wave, and said second constant width is a second integer multiple of one-half wavelength of said standing wave.