Patent ID: 11918600
Assignee: SUZHOU RIBO LIFE SCIENCE CO., LTD.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 21:
22. A siRNA conjugate having a structure as shown by Formula (401):, wherein,
n1 is an integer of 1-3, and n3 is an integer of 0-4;
m1, m2, and m3 independently of one another are an integer of 2-10;
R10, R11, R12, R13, R14 and R15 independently of one another are one of H, methyl or ethyl;
R3 is a group having a structure as shown by Formula (A59):, wherein,
E1 is OH, SH or BH2; Nu is the siRNA according to claim 1;
R2 is any group capable of linking to the N atom on the nitrogenous backbone and linking to A59;
each L1 is independently selected from the linkage combinations of one or more of Formulae A1-A26:, wherein j1 is an integer of 1-20; j2 is an integer of 1-20;
R′ is a C1-C10 alkyl;
Ra is selected from one of Formulae A27-A45:, Rb is a C1-C10 alkyl; and
 represents the site where a group is covalently linked;
each M1 is independently selected from one of the ligands that have affinity to the asialoglycoprotein receptors (ASGP-R) on the surface of mammalian hepatocytes.