Patent ID: 11969476
Assignee: VISTERRA, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C  Y | IPC A  C

Claim 6:
7. An ADC comprising an antibody molecule comprising two VHs and two VLs,
wherein the VH is covalently coupled with a peptide comprising the amino acid sequence of SEQ ID NO: 257; and
wherein:
(i) the VH comprises an HCDR1 comprising the amino acid sequence of SEQ ID NO: 105; an HCDR2 comprising the amino acid sequence of SEQ ID NO: 106; and an HCDR3 comprising the amino acid sequence of SEQ ID NO: 107; and the VL comprises an LCDR1 comprising the amino acid sequence of SEQ ID NO: 138; an LCDR2 comprising the amino acid sequence of SEQ ID NO: 142; and an LCDR3 comprising the amino acid sequence of SEQ ID NO: 112; or
(ii) the VH comprises an HCDR1 comprising the amino acid sequence of SEQ ID NO: 108; an HCDR2 comprising the amino acid sequence of SEQ ID NO: 146; and an HCDR3 comprising the amino acid sequence of SEQ ID NO: 107; and the VL comprises an LCDR1 comprising the amino acid sequence of SEQ ID NO: 138; an LCDR2 comprising the amino acid sequence of SEQ ID NO: 142; and an LCDR3 comprising the amino acid sequence of SEQ ID NO: 112 wherein the peptide is coupled to the C-terminus of the VH via a (Gly-Ser)n linker, where n=2 to 20 (SEQ ID NO: 262).