Patent ID: 11970563
Assignee: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A  B | IPC A  B  C

Claim 12:
13. A method of forming a nanoparticulate composition according to claim 1 using polymerisation induced self-assembly, the method comprising the step of forming a block copolymer by reacting a monomeric material with a macroinitiator compound in the presence of an initiator compound, a catalyst and a solvent, wherein:
if the monomeric material polymerises to provide a hydrophobic polymer block, then the macroinitiator compound is a hydrophilic polymer or oligomer or if the monomeric material polymerises to provide a hydrophilic polymer block, then the macroinitiator compound is a hydrophobic polymer or oligomer;
the macroinitiator compound is terminated with a halogen atom;
the monomeric material, the macroinitiator compound, the initiator compound, the catalyst and the solvent are all substantially free of compounds comprising sulfur; and
the monomeric material, the macroinitiator compound, the initiator compound, the catalyst and the solvent are all substantially free of a heavy metal.