Patent ID: 11952433
Assignee: INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  G  A | IPC A  C  G

Claim 0:
1. A method for analyzing an NMR spectrum of a biomolecule, comprising:
(a) a step of mixing a peptide complex in a mixture solvent;
(b) a step of adding a biomolecule to be measured in the mixture solution; and
(c) a step of conducting NMR measurement for the mixture of the biomolecule and the peptide complex, wherein the peptide complex comprises a peptide represented by General Formula 1 or 2, comprising a heterochiral peptide; and a compound represented by Chemical Formula 1, covalently bound to N-terminal of the peptide:

[Y1]a-{-[X1]b-[Y2]c}d-[X2]e  [General Formula 1]

[X1]r{-[Y1]g-[X2]h}i-[Y2]j  [General Formula 2]

wherein
each of X1 and X2, which are identical to or different from each other, is independently an amino acid selected from D-Trp, D-Phe, D-Tyr, D-Val, D-Leu and D-Ile,
each of Y1 and Y2, which are identical to or different from each other, is independently an amino acid selected from L-Trp, L-Phe, L-Tyr, L-Val, L-Leu and L-Ile, and
each of a, f, e and j is independently an integer selected from 0 to 2, each of b, c, g and h is independently an integer selected from 1 to 5, each of d and i is independently an integer selected from 1 to 10,, wherein each of n and m is independently an integer selected from 1 to 12,
wherein the peptide represented by General Formula 1 or General Formula II comprises at least five amino acid residues,
wherein the amino acid in position 3, relative to the N-terminal of the peptide, is selected from the group consisting of D-Trp, D-Phe, D-Tyr, D-Val, D-Leu, D-Ile, L-Trp, L-Tyr, L-Val, L-Leu and L-Ile.