Patent ID: 11931418
Assignee: ASHVATTHA THERAPEUTICS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 24:
25. A method for treating one or more symptoms of severe inflammation in an organ of a subject in need thereof, the method comprising:
administering to the subject a composition comprising dendrimers complexed, covalently conjugated, or intra-molecularly dispersed or encapsulated with N-acetyl cysteine, in an amount effective to treat one or more symptoms of severe inflammation,
wherein the severe inflammation is hyperinflammation associated with elevated levels of CRP,
wherein the composition is administered in an amount effective to reduce vascular leakage or vascular permeability in the lung, increase alveolar cell integrity or endothelial cell integrity in the lung, increase the ratio of arterial oxygen to the fraction of inspired oxygen (PaO2/FiO2), increase pulse oximetry-based peripheral blood oxygen saturation (SpO2/FiO2) ratios, and/or reduce bronchoalveolar lavage (BAL) protein levels or bronchoalveolar lavage cell count.