Patent ID: 11891454
Assignee: ICHNOS SCIENCES SA
Field: Biotechnology (Chemistry)
Classification: CPC C | IPC C

Claim 8:
9. The hetero-dimeric immunoglobulin or fragment thereof of claim 1, wherein the heavy chain variable region comprises an amino acid substitution selected from the group consisting of: W100eF and W100eY, according to Kabat numbering and the light chain variable region comprises an amino acid substitution selected from the group consisting of: A2I, S25A, T27A, G27aA, V27cA, T28A, T29A, S30A, N31A, Y32A, E38Q, F44P, G46L, T51A N52A, K53A, R54A, P56A, L66G, D69T, F87Y, Q89A, W91F, Y92A, S93A, N94A, and Q100G, according to Kabat numbering; or wherein the heavy chain variable region comprises the amino acid substitutions W100eY, according to Kabat numbering and the light chain variable region comprises the amino acid substitutions A2I, T29A, S30A, T51A, F87Y, Q89A, and W91F, according to Kabat numbering or light chain variable region comprises the amino acid substitutions A2I, E38Q, F87Y, and Q89A.