Patent ID: 11919953
Assignee: AMGEN INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A  Y | IPC A  C

Claim 1:
2. The CD112R antigen-binding protein of claim 1, comprising (I) a HC variable region and LC variable region comprising the amino acid sequences selected from the group consisting of: (a) SEQ ID NOs: 11-12, respectively; (b) SEQ ID NOs: 21-22, respectively; (c) SEQ ID NOs: 31-32, respectively; (d) SEQ ID NOs: 41-42, respectively; (e) SEQ ID NOs: 51-52, respectively; (f) SEQ ID NOs: 61-62, respectively; (g) SEQ ID NOs: 71-72, respectively; (h) SEQ ID NOs: 81-82, respectively; (i) SEQ ID NOs: 91-92, respectively; (j) SEQ ID NOs:101-102, respectively; (k) SEQ ID NOs: 231-232, respectively; (l) SEQ ID NOs: 1971-1972, respectively; (m) SEQ ID NOs: 1981-1982, respectively; (n) SEQ ID NOs: 1991-1992, respectively; and (o) SEQ ID NOs: 2001-2002, respectively, or (II) (a) a HC variable region comprising an amino acid sequence having at least 90% sequence identity to SEQ ID NO: 11 and a LC variable region comprising an amino acid sequence having at least 90% sequence identity to SEQ ID NO: 12; (b) a HC variable region comprising an amino acid sequence having at least 90% sequence identity to SEQ ID NO: 21 and a LC variable region comprising an amino acid sequence having at least 90% sequence identity to SEQ ID NO: 22; (c) a HC variable region comprising an amino acid sequence having at least 90% sequence identity to SEQ ID NO: 31 and a LC variable region comprising an amino acid sequence having at least 90% sequence identity to SEQ ID NO: 32; (d) a HC variable region comprising an amino acid sequence having at least 90% sequence identity to SEQ ID NO: 41 and a LC variable region comprising an amino acid sequence having at least 90% sequence identity to SEQ ID NO: 42; (e) a HC variable region comprising an amino acid sequence having at least 90% sequence identity to SEQ ID NO: 51 and a LC variable region comprising an amino acid sequence having at least 90% sequence identity to SEQ ID NO: 52; (f) a HC variable region comprising an amino acid sequence having at least 90% sequence identity to SEQ ID NO: 61 and a LC variable region comprising an amino acid sequence having at least 90% sequence identity to SEQ ID NO: 62; (g) a HC variable region comprising an amino acid sequence having at least 90% sequence identity to SEQ ID NO: 71 and a LC variable region comprising an amino acid sequence having at least 90% sequence identity to SEQ ID NO: 72; (h) a HC variable region comprising an amino acid sequence having at least 90% sequence identity to SEQ ID NO: 81 and a LC variable region comprising an amino acid sequence having at least 90% sequence identity to SEQ ID NO: 82; (i) a HC variable region comprising an amino acid sequence having at least 90% sequence identity to SEQ ID NO: 91 and a LC variable region comprising an amino acid sequence having at least 90% sequence identity to SEQ ID NO: 92; (j) a HC variable region comprising an amino acid sequence having at least 90% sequence identity to SEQ ID NO: 101 and a LC variable region comprising an amino acid sequence having at least 90% sequence identity to SEQ ID NO: 102; (k) a HC variable region comprising an amino acid sequence having at least 90% sequence identity to SEQ ID NO: 231 and a LC variable region comprising an amino acid sequence having at least 90% sequence identity to SEQ ID NO: 232; (1) a HC variable region comprising an amino acid sequence having at least 90% sequence identity to SEQ ID NO: 1971 and a LC variable region comprising an amino acid sequence having at least 90% sequence identity to SEQ ID NO: 1972; (m) a HC variable region comprising an amino acid sequence having at least 90% sequence identity to SEQ ID NO: 1981 and a LC variable region comprising an amino acid sequence having at least 90% sequence identity to SEQ ID NO: 1982; (n) a HC variable region comprising an amino acid sequence having at least 90% sequence identity to SEQ ID NO: 1991 and a LC variable region comprising an amino acid sequence having at least 90% sequence identity to SEQ ID NO: 1992; (o) a HC variable region comprising an amino acid sequence having at least 90% sequence identity to SEQ ID NO: 2001 and a LC variable region comprising an amino acid sequence having at least 90% sequence identity to SEQ ID NO: 2002.