Patent ID: 11884920
Assignee: ARROWHEAD PHARMACEUTICALS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A  G | IPC A  C  G

Claim 10:
11. The RNAi agent of claim 10, wherein the sense strand comprises the sequence (5′→3′) agcguuuaGfGfCfauguuuaaca (SEQ ID NO: 1279), wherein:
a, c, g, and u are 2′-O-methyl adenosine, 2′-O-methyl cytidine, 2′-O-methyl guanosine, and 2′-O-methyl uridine, respectively;
Af, Cf, Gf, and Uf are 2′-fluoro adenosine, 2′-fluoro cytidine, 2′-fluoro guanosine, and 2′-fluoro uridine, respectively; and
s is a phosphorothioate linkage;
wherein optionally present on the sense strand is one or two inverted abasic deoxyribose residues (invAb) and/or one, two, three, or four phosphorothioate internucleoside linkages; and
wherein optionally linked to the 5′ terminal end of the sense strand is a targeting ligand that comprises N-acetyl-galactosamine.