Patent ID: 11955241
Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Field: Measurement (Instruments)
Classification: CPC G  Y | IPC G

Claim 3:
4. The method of claim 1, further comprising:
treating the subject with one or more treatments for vascular anomalies or malformations wherein the subject has a vascular anomaly or malformation selected from the group consisting of AVM, VM, PWS, SWS, KTWS, hemangioma, cavernoma, capillary telangiectasia, Dural AV fistula, and angiokeratoma;
obtaining a second skin tissue biopsy sample(s) and/or EV serum sample(s) from the subject after treatment, where the skin tissue biopsy sample(s) and/or EV serum sample(s) are from the same general area as the sample(s) obtained prior to treatment;
measuring a second expression profile of the set of pathogenic associated biomarkers and/or serum EV biomarkers from the subject's skin tissue biopsy sample(s) and/or EV serum sample(s) obtained after treatment;
comparing the expression profile of the set of pathogenic associated biomarkers and/or serum EV biomarkers prior to treatment with the second expression profile of the set pathogenic associated biomarkers and/or serum EV biomarkers after treatment, wherein the same set of pathogenic associated biomarkers and/or serum EV biomarkers are compared between the expression profiles; and
identifying whether the treatment for the vascular anomalies or malformations was effective based upon an improvement in the second expression profile for the biomarkers after treatment in comparison with the expression profile of the biomarkers prior to treatment.