Patent ID: 11940510
Assignee: NVISION IMAGING TECHNOLOGIES GMBH
Field: Pharmaceuticals (Chemistry)
Classification: CPC G  A  C | IPC A  C  G

Claim 0:
1. A system for increasing nuclear spin polarization, comprising:
a chamber configurable to contain at least 1 milliliter (mL) of a solution comprising a precursor at a concentration of between 10 and 1000 millimolar (mM);
a radiofrequency (RF) coil disposed around the chamber, the RF coil comprising a proton (1H) channel and a carbon-13 (13C) channel;
a magnetic field source configured to generate a magnetic field, the magnetic field having, within the chamber, a mean magnetic field strength between 1 and 6000 millitesla (mT) and a magnetic field inhomogeneity between 1 and 250 microtesla (μT);
a flow manifold coupled to a gas-liquid exchange mechanism configurable to mix parahydrogen gas with the solution to generate a parahydrogenated precursor; and
a waveform generator configurable to generate a polarized precursor by providing RF stimulation to the RF coil, a nuclear spin polarization of the polarized precursor at least 10%, the RF stimulation comprising:
(i) a first pulse sequence, provided to the 1H channel, comprising at least one 1H excitation pulse and a first set of at least ten 1H dynamic decoupling pulses; and
(ii) a second pulse sequence, provided to the 13C channel, comprising at least one 13C excitation pulse, and a second set of at least ten 13C dynamic decoupling pulses.