Patent ID: 11883485
Assignee: FRED HUTCHINSON CANCER CENTER
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A

Claim 2:
3. The method of claim 2, wherein the N-terminal truncation is before residue 49, 48, 47, 46, 45, 44, 43, 42, 41, 40 or 39, the flexible linker has a sequence as set forth in one of SEQ ID NOs: 57-68, the 426c core HIV-1 Env further comprises a C-terminal truncation after residue 499, 498, 497, 496, 495, 494, 493, 492, 491, 490 or 389 and wherein residue numbering is based on the prototypic HIV-1 isolate HxB2.