Patent ID: 11932701
Assignee: IMMUNOGEN, INC.
Field: Measurement (Instruments)
Classification: CPC C  A  G | IPC A  C  G

Claim 0:
1. A method for increasing the efficacy of cancer therapy with an active agent comprising an anti-FOLR1 immunoconjugate comprising an anti-FOLR1 antibody or antigen-binding fragment thereof, said method comprising administering the active agent to a subject having cancer, wherein increased expression of FOLR1 has been detected in a cancerous sample from said subject in an immunohistochemistry (IHC) assay using a detection antibody or antigen-binding fragment thereof
wherein the detection antibody or antigen-binding fragment thereof is an anti-FOLR1 antibody or antigen-binding fragment thereof that specifically binds to an epitope of FOLR1 comprising an N-glycosylated amino acid wherein said detection antibody or antigen-binding fragment thereof competitively inhibits binding to FOLR1 of an antibody comprising a heavy chain variable region (VH) comprising the amino acid sequence of SEO ID NO:27 and a light chain variable region (VL) comprising the amino acid sequence of SEO ID NO:28.