Patent ID: 11881286
Assignee: GENENTECH, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC G  A  C | IPC A  C  G

Claim 13:
14. A method comprising:
receiving a result of processing of a sample from a subject to characterize immunoactivity, wherein the result comprises gene expression level data corresponding to the subject for a predefined set of genes, wherein for each gene in the predefined set of genes, an expression level of the gene had been identified as being informative of a quantity or a spatial distribution of CD8+ T cells, and wherein the result further comprises either the quantity of CD8+ T cells in the sample or a portion thereof determined based on the gene expression level data or the spatial distribution of CD8+ T cells in the sample of a portion thereof characterized based on the gene expression level data;
detecting, based on the result, an immunosuppressive tumor microenvironment within the sample or the portion thereof; and
prompting treatment of the subject with an inhibitor of TGFβ.