Patent ID: 11873330
Assignee: GENENTECH, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 1:
2. An isolated cysteine engineered antibody comprising a free cysteine amino acid, wherein the cysteine engineered antibody comprises a sequence in the heavy chain selected from
HC-T200C with the sequence SLGTQCYICNV (SEQ ID NO: 92) and
HC-T212C with the sequence HKPSNCKVDKK (SEQ ID NO: 95);, or a sequence in the light chain selected from
LC-Q155C with the sequence VDNALCSGNSQ (SEQ ID NO: 135) and
LC-T206C with the sequence LSSPVCKSFNR (SEQ ID NO: 146);, wherein the free cysteine amino acid is in the center of the sequence.