Patent ID: 11911453
Assignee: MODERNATX, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A

Claim 0:
1. A respiratory syncytial virus (RSV) messenger ribonucleic acid (mRNA) vaccine composition, comprising:
an mRNA that comprises an open reading frame (ORF) encoding an RSV F protein comprising an amino acid sequence having at least 95% identity to the amino acid sequence of SEQ ID NO: 5, wherein identity defines the percentage of amino acid residues in the RSV F protein that are identical to residues of SEQ ID NO: 5 after introducing any necessary gaps to align the two full-length sequences; and
a lipid nanoparticle comprising 20-60 mol % ionizable cationic lipid, 5-25 mol % neutral lipid, 25-55 mol % sterol, and 0.5-15 mol % PEG-modified lipid.