Patent ID: 11912978
Assignee: NOVARTIS AG
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C  B | IPC A  B  C

Claim 0:
1. A cell processing system comprising:
a flow-through magnetic separation/deb eading module, comprising:
a flow chamber defined by a plurality of walls,
an inlet arranged at a first end of the flow chamber for flowing a cell suspension comprising paramagnetic particle-bound cells and unbound cells into the flow chamber,
an outlet arranged at a second end of the flow chamber opposite the first end of the flow chamber,
a magnet assembly adjacent or proximate a wall of the flow chamber and configured to assert a magnetic force within the flow chamber,
a plurality of fluid injection ports arranged along a wall of the plurality of walls of the flow chamber, the plurality of fluid injection ports being positioned between the first end and the second end of the flow chamber, and
a membrane located above the plurality of fluid injection ports, wherein the membrane is configured to allow a fluid introduced through the plurality of injection ports to supply a force to any cells of the cell suspension stuck to the membrane sufficient to dislodge the cells from the membrane;

wherein the magnetic separation/debeading module is configured to establish the magnetic force within the flow chamber and the flow of the cell suspension through the flow chamber to both separate the paramagnetic particle-bound cells from the unbound cells and to debead a portion of the paramagnetic particle-bound cells.