Patent ID: 11905327
Assignee: NANJING LEGEND BIOTECH CO., LTD.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A  Y | IPC A  C

Claim 11:
12. The anti-TIGIT construct of claim 10, wherein the anti-TIGIT construct comprises a configuration selected from the group consisting of:
(a) the N-terminus of the sdAb moiety specifically recognizing TIGIT is fused to the C-terminus of at least one of the heavy chains of the full-length antibody;
(b) the C-terminus of the sdAb moiety specifically recognizing TIGIT is fused to the N-terminus of at least one of the heavy chains of the full-length antibody;
(c) the N-terminus of the sdAb moiety specifically recognizing TIGIT is fused to the C-terminus of at least one of the light chains of the full-length antibody; and
(d) the C-terminus of the sdAb moiety specifically recognizing TIGIT is fused to the N-terminus of at least one of the light chains of the full-length antibody.