Patent ID: 11938109
Assignee: EMP LEVO US B.V.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 10:
11. A method for the preparation of an oral levothyroxine solution of claim 1, comprising the steps of:
a) combining:
i) levothyroxine or a salt thereof,
ii) 20-80 w/w % of a water-miscible organic solvent or a sugar alcohol or a combination thereof,
iii) water,

b) adjusting the pH to at least 8 providing a basic aqueous medium,
c) dissolving the levothyroxine in the basic aqueous medium to yield a levothyroxine solution, and
d) lowering the pH of the levothyroxine solution to between 3.5-4.9,
e) adding a preservative and allowing the preservative to dissolve.