Patent ID: 11884718
Assignee: THE GOVERNMENT OF THE UNITED STATES, AS REPRESENTED BY THE SECRETARY OF THE ARMY
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A  G  Y | IPC A  C  G

Claim 3:
4. The antibody or fragment thereof of claim 1,
(a) wherein said antibody or antibody fragment inhibits or prevents Zika virus infection, Dengue virus infection, infection by Dengue virus serotype 2, infection by Dengue virus serotype 3, Zika virus transmission from a pregnant female to a fetus, sexual transmission of Zika virus, or infection of human testes by Zika virus;
(b) wherein said antibody or antibody fragment has an ED50 for neutralizing Zika infection of less than 10 mg/kg;
(c) wherein 100 μg/ml of said antibody or antibody fragment does not neutralize infection by a flavivirus selected from the group of Dengue virus, Japanese Encephalitis virus, West Nile virus, or Yellow Fever virus;
(d) wherein said antibody or antibody fragment has an IC50 for neutralizing Zika infection of less than 10 μM; and/or
(e) wherein said antibody or antibody fragment has an equilibrium dissociation constant (KD) in the range from 10−7 to 10−9 molar, or less than 10−7 molar.