Patent ID: 11913955
Assignee: TOSOH CORPORATION
Field: Measurement (Instruments)
Classification: CPC G  C | IPC G

Claim 1:
2. A method of detecting a level of a fragment of intact growth and differentiation factor 15 (GDF15) propeptide (GDF15 propeptide fragment) in a sample of a subject having cancer, the method comprising:
measuring the GDF15 propeptide fragment level in the sample, and
comparing the GDF15 propeptide fragment level obtained by the measurement with a reference value calculated from a control,
wherein the intact GDF15 propeptide consists of the amino acid sequence from the leucine at the 30th residue to the arginine at the 194th residue in the GDF15 amino acid sequence of SEQ ID NO:2,
wherein the GDF15 propeptide fragment is selected from the group consisting of the following GDF15 propeptide fragment (A) and the following GDF15 propeptide fragment (B):
(A) a GDF15 propeptide fragment having the following properties:
contains an amino acid sequence from the lysine at the 58th residue to at least the aspartic acid at the 167th residue in the GDF15 amino acid sequence of SEQ ID NO:2;
(B) a GDF15 propeptide fragment having the following properties:
contains an amino acid sequence from the glutamic acid at the 74th residue to at least the aspartic acid at the 167th residue in the GDF15 amino acid sequence of SEQ ID NO:2, and
wherein the cancer is one or more selected from the group consisting of stomach cancer, pancreatic cancer, colorectal cancer, lung cancer, breast cancer, esophageal cancer, non-small cell lung cancer, and small cell lung cancer.