Patent ID: 11858922
Assignee: THE UNIVERSITY OF QUEENSLAND
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 6:
7. The method of claim 5, wherein the disease, disorder or condition is selected from the group consisting of;
(i) constitutive inflammation, autoinflammatory diseases, autoimmune disease respiratory diseases, central nervous system diseases, metabolic diseases, ocular diseases, kidney disease, liver disease, inflammatory reactions in skin, inflammatory reactions in the joints, viral infections, and cancers; or
(ii) cryopyrin-associated periodic syndromes (CAPS); Muckle-Wells syndrome (MWS); familial cold autoinflammatory syndrome (FCAS); neonatal-onset multisystem inflammatory disease (NOMID); familial Mediterranean fever (FMF); TNF receptor associated periodic syndrome (TRAPS); mevalonate kinase deficiency (MKD); hyperimmunoglobulinemia D and periodic fever syndrome (HIDS); deficiency of interleukin 1 receptor antagonist (DIRA); Majeed syndrome; pyogenic arthritis, pyoderma gangrenosum and acne syndrome (PAPA); haploinsufficiency of A20 (HA20); pediatric granulomatous arthritis (PGA); PLCG2-associated antibody deficiency and immune dysregulation (PLAID); autoinflammation, PLCG2-associated antibody deficiency and immune dysregulation (APLAID); sideroblastic anemia with B-cell immunodeficiency, periodic fevers, and developmental delay (SIFD); multiple sclerosis (MS); type-1 diabetes; psoriasis; rheumatoid arthritis; Behcet's disease; Sjogren's syndrome; Schnitzler syndrome; chronic obstructive pulmonary disorder (COPD); steroid-resistant asthma; asbestosis; silicosis; cystic fibrosis; Parkinson's disease; Alzheimer's disease; motor neuron disease; Huntington's diseases; cerebral malaria; brain injury from pneumococcal meningitis; Type 2 diabetes; atherosclerosis; obesity; gout; pseudo-gout; ocular diseases of the ocular epithelium; age-related macular degeneration (AMD); corneal infection; dry eye; chronic kidney disease; oxalate nephropathy; diabetic nephropathy; non-alcoholic steatohepatitis (NASH); alcoholic liver disease; contact hypersensitivity; sunburn; osteoarthritis; systemic juvenile idiopathic arthritis; adult-onset Still's disease; relapsing polychondritis; infections with alpha virus (Chikungunya, Ross River); infection with flavivirus (Dengue, Zika); flu; HIV; hidradenitis suppurativa (HS); cyst-causing skin diseases; lung cancer metastasis; pancreatic cancers; gastric cancers; myelodysplastic syndrome; leukemia; polymyositis; stroke; myocardial infarction; Graft versus Host Disease; hypertension; colitis; helminth infection; bacterial infection; abdominal aortic aneurism; wound healing; depression; psychological stress; ischaemia reperfusion injury; and diseases where an individual has been determined to carry a germline or somatic non-silent mutation in NLRP3.