Patent ID: 11896575
Assignee: DELIVRA INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 15:
16. The transdermal formulation of claim 1, wherein:
the transdermal formulation further comprises an oily vehicle comprising mono-, di- and triglycerides,
optionally wherein the oily vehicle is obtained by alcoholysis between glycerol and refined corn oil, followed by winterization to remove saturated mono-, di- and triglycerides;
optionally wherein the oily vehicle comprises:
i) about 25-75% (or about 32-52%) of monoglycerides of oleic and linoleic acid;
ii) about 25-75% (or about 40-55%) of diglycerides of oleic and linoleic acid; and
iii) about 1-50% (or about 5-20%) of triglycerides of oleic and linoleic acid; or the hydrophobic active agent is pre-solubilized in an oil formulation, the oil formulation comprising:
i) the hydrophobic active agent;
ii) an oily vehicle comprising mono-, di- and triglycerides;
iii) at least one polar oil, optionally argan oil, sunflower oil, olive oil, avocado oil or jojoba oil; and
iv) the penetration enhancer; or
the hydrophobic active agent is pre-solubilized in an oil formulation, the oil formulation comprising:
i) the hydrophobic active agent comprises a cannabinoid or terpene, wherein the cannabinoid is CO2 extracted, in an amount between about 5-10% (w/w), or about 6.6%;
ii) an oily vehicle comprising mono-, di- and triglycerides in an amount between about 20%-60%, or about 40.0%;
iii) a polar oil, optionally argan oil, sunflower oil, olive oil, avocado oil or jojoba oil, present in an amount between about 25%-50%, or about 33.4%; and
iv) the penetration enhancer, present in an amount between about 10%-30%, or about 20.0%.