Patent ID: 11905291
Assignee: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
Field: nan (nan)
Classification: CPC nan | IPC C

Claim 9:
10. A bivalent compound selected from the group consisting of:, 369 

N-(3′-((4-((S)-3-((2S,4R)-4-hydroxy-1- ((R)-3-methyl-2-(3-methylisoxazol-5- yl)butanoyl)pyrrolidine-2- carboxamido)-3-(4-(4-methylthiazol-5- yl)phenyl)propanoyl)piperazin-1- yl)methyl)-4-(4-methylpiperazin-1-yl)- [1,1′-biphenyl]-3-yl)-6-oxo-4- (trifluoromethyl)-1,6- dihydropyridine-3-carboxamide 

 

373 

N-(3′-((4-(5-((S)-3-((2S,4R)-4-hydroxy- 1-((R)-3-methyl-2-(3-methylisoxazol-5- yl)butanoyl)pyrrolidine-2- carboxamido)-3-(4-(4-methylthiazol-5- yl)phenyl)propanamido)pentanoyl) piperazin-1-yl)methyl)-4-(4- methylpiperazin-1-yl)-[1,1′-biphenyl]- 3-yl)-6-oxo-4-(trifluoromethyl)-1,6- dihydropyridine-3-carboxamide 

 

374 

N-(3′-((4-(6-((S)-3-((2S,4R)-4-hydroxy- 1-((R)-3-methyl-2-(3-methylisoxazol-5- yl)butanoyl)pyrrolidine-2- carboxamido)-3-(4-(4-methylthiazol-5- yl)phenyl)propanamido)hexanoyl) piperazin-1-yl)methyl)-4-(4- methylpiperazin-1-yl)-[1,1′-biphenyl]- 3-yl)-6-oxo-4-(trifluoromethyl)-1,6- dihydropyridine-3-carboxamide 

 

375 

N-(3′-((4-(7-((S)-3-((2S,4R)-4-hydroxy- 1-((R)-3-methyl-2-(3-methylisoxazol-5- yl)butanoyl)pyrrolidine-2- carboxamido)-3-(4-(4-methylthiazol-5- yl)phenyl)propanamido)heptanoyl) piperazin-1-yl)methyl)-4-(4- methylpiperazin-1-yl)-[1,1′-biphenyl]- 3-yl)-6-oxo-4-(trifluoromethyl)-1,6- dihydropyridine-3-carboxamide 

 

376 

N-(3′-((4-(8-((S)-3-((2S,4R)-4-hydroxy- 1-((R)-3-methyl-2-(3-methylisoxazol-5- yl)butanoyl)pyrrolidine-2- carboxamido)-3-(4-(4-methylthiazol-5- yl)phenyl)propanamido)octanoyl) piperazin-1-yl)methyl)-4-(4- methylpiperazin-1-yl)-[1,1′-biphenyl]- 3-yl)-6-oxo-4-(trifluoromethyl)-1,6- dihydropyridine-3-carboxamide 

 

377 

N-(3′-((4-(9-((S)-3-((2S,4R)-4-hydroxy- 1-((R)-3-methyl-2-(3-methylisoxazol-5- yl)butanoyl)pyrrolidine-2- carboxamido)-3-(4-(4-methylthiazol-5- yl)phenyl)propanamido)nonanoyl) piperazin-1-yl)methyl)-4-(4- methylpiperazin-1-yl)-[1,1′-biphenyl]- 3-yl)-6-oxo-4-(trifluoromethyl)-1,6- dihydropyridine-3-carboxamide 

 

378 

N-(3′-((4-(10-((S)-3-((2S,4R)-4- hydroxy-1-((R)-3-methyl-2-(3- methylisoxazol-5- yl)butanoyl)pyrrolidine-2- carboxamido)-3-(4-(4-methylthiazol-5- yl)phenyl)propanamido)decanoyl) piperazin-1-yl)methyl)-4-(4- methylpiperazin-1-yl)-[1,1′-biphenyl]- 3-yl)-6-oxo-4-(trifluoromethyl)-1,6- dihydropyridine-3-carboxamide 

 

379 

N-(3′-((4-(11-((S)-3-((2S,4R)-4- hydroxy-1-((R)-3-methyl-2-(3- methylisoxazol-5- yl)butanoyl)pyrrolidine-2- carboxamido)-3-(4-(4-methylthiazol-5- yl)phenyl)propanamido)undecanoyl) piperazin-1-yl)methyl)-4-(4- methylpiperazin-1-yl)-[1,1′-biphenyl]- 3-yl)-6-oxo-4-(trifluoromethyl)-1,6- dihydropyridine-3-carboxamide 

 

380 

N-(3′-((4-((S)-3-((2S,4R)-1-((S)-2-(1- fluorocyclopropane-1-carboxamido)- 3,3-dimethylbutanoyl)-4- hydroxypyrrolidine-2-carboxamido)- 3-(4-(4-methylthiazol-5- yl)phenyl)propanoyl)piperazin-1- yl)methyl)-4-(4-methylpiperazin-1-yl)- [1,1′-biphenyl]-3-yl)-6-oxo-4- (trifluoromethyl)-1,6- dihydropyridine-3-carboxamide 

 

387 

N-(3′-((4-(8-((S)-3-((2S,4R)-1-((S)-2-(1- fluorocyclopropane-1-carboxamido)- 3,3-dimethylbutanoyl)-4- hydroxypyrrolidine-2-carboxamido)- 3-(4-(4-methylthiazol-5- yl)phenyl)propanamido)octanoyl) piperazin-1-yl)methyl)-4-(4- methylpiperazin-1-yl)-[1,1′-biphenyl]- 3-yl)-6-oxo-4-(trifluoromethyl)-1,6- dihydropyridine-3-carboxamide 

 

388 

N-(3′-((4-(9-((S)-3-((2S,4R)-1-((S)-2-(1- fluorocyclopropane-1-carboxamido)- 3,3-dimethylbutanoyl)-4- hydroxypyrrolidine-2-carboxamido)- 3-(4-(4-methylthiazol-5- yl)phenyl)propanamido)nonanoyl) piperazin-1-yl)methyl)-4-(4- methylpiperazin-1-yl)-[1,1′-biphenyl]- 3-yl)-6-oxo-4-(trifluoromethyl)-1,6- dihydropyridine-3-carboxamide 

 

389 

N-(3′-((4-(10-((S)-3-((2S,4R)-1-((S)-2- (1-fluorocyclopropane-1- carboxamido)-3,3-dimethylbutanoyl)- 4-hydroxypyrrolidine-2- carboxamido)-3-(4-(4-methylthiazol-5- yl)phenyl)propanamido)decanoyl) piperazin-1-yl)methyl)-4-(4- methylpiperazin-1-yl)-[1,1′-biphenyl]- 3-yl)-6-oxo-4-(trifluoromethyl)-1,6- dihydropyridine-3-carboxamide 

 

391 

N-(3′-((4-(1′-((S)-3-((2S,4R)-4- hydroxy-1-((R)-3-methyl-2-(3- methylisoxazol-5- yl)butanoyl)pyrrolidine-2- carboxamido)-3-(4-(4-methylthiazol-5- yl)phenyl)propanoyl)-[1,4′- bipiperidine]-4-carbonyl)piperazin-1- yl)methyl)-4-(4-methylpiperazin-1-yl)- [1,1′-biphenyl]-3-yl)-6-oxo-4- (trifluoromethyl)-1,6- dihydropyridine-3-carboxamide 

 

392 

1′-((S)-3-((2S,4R)-4-hydroxy-1-((R)-3- methyl-2-(3-methylisoxazol-5- yl)butanoyl)pyrrolidine-2- carboxamido)-3-(4-(4-methylthiazol-5- yl)phenyl)propanoyl)-N-(2-(4-((4′-(4- methylpiperazin-1-yl)-3′-(6-oxo-4- (trifluoromethyl)-1,6- dihydropyridine-3-carboxamido)- [1,1′-biphenyl]-3-yl)methyl)piperazin- 1-yl)ethyl)-[1,4′-bipiperidine]-4- carboxamide 

 

396 

N-(2′-fluoro-5′-((3-((S)-3-((2S,4R)-4- hydroxy-1-((R)-3-methyl-2-(3- methylisoxazol-5- yl)butanoyl)pyrrolidine-2- carboxamido)-3-(4-(4-methylthiazol-5- yl)phenyl)propanamido)propyl) carbamoyl)-4-((3S,5R)-3,4,5- trimethylpiperazin-1-yl)-[1,1′- biphenyl]-3-yl)-6-oxo-4- (trifluoromethyl)-1,6- dihydropyridine-3-carboxamide 

 

397 

N-(2′-fluoro-5′-((4-((S)-3-((2S,4R)-4- hydroxy-1-((R)-3-methyl-2-(3- methylisoxazol-5- yl)butanoyl)pyrrolidine-2- carboxamido)-3-(4-(4-methylthiazol-5- yl)phenyl)propanamido)butyl) carbamoyl)-4-((3S,5R)-3,4,5- trimethylpiperazin-1-yl)-[1,1′- biphenyl]-3-yl)-6-oxo-4- (trifluoromethyl)-1,6- dihydropyridine-3-carboxamide 

 

398 

N-(2′-fluoro-5′-((5-((S)-3-((2S,4R)-4- hydroxy-1-((R)-3-methyl-2-(3- methylisoxazol-5- yl)butanoyl)pyrrolidine-2- carboxamido)-3-(4-(4-methylthiazol-5- yl)phenyl)propanamido)pentyl) carbamoyl)-4-((3S,5R)-3,4,5- trimethylpiperazin-1-yl)-[1,1′- biphenyl]-3-yl)-6-oxo-4- (trifluoromethyl)-1,6- dihydropyridine-3-carboxamide 

 

399 

N-(2′-fluoro-5′-((6-((S)-3-((2S,4R)-4- hydroxy-1-((R)-3-methyl-2-(3- methylisoxazol-5- yl)butanoyl)pyrrolidine-2- carboxamido)-3-(4-(4-methylthiazol-5- yl)phenyl)propanamido)hexyl) carbamoyl)-4-((3S,5R)-3,4,5- trimethylpiperazin-1-yl)-[1,1′- biphenyl]-3-yl)-6-oxo-4- (trifluoromethyl)-1,6- dihydropyridine-3-carboxamide 

 

400 

N-(2′-fluoro-5′-((7-((S)-3-((2S,4R)-4- hydroxy-1-((R)-3-methyl-2-(3- methylisoxazol-5- yl)butanoyl)pyrrolidine-2- carboxamido)-3-(4-(4-methylthiazol-5- yl)phenyl)propanamido)heptyl) carbamoyl)-4-((3S,5R)-3,4,5- trimethylpiperazin-1-yl)-[1,1′- biphenyl]-3-yl)-6-oxo-4- (trifluoromethyl)-1,6- dihydropyridine-3-carboxamide 

 

401 

N-(2′-fluoro-5′-((8-((S)-3-((2S,4R)-4- hydroxy-1-((R)-3-methyl-2-(3- methylisoxazol-5- yl)butanoyl)pyrrolidine-2- carboxamido)-3-(4-(4-methylthiazol-5- yl)phenyl)propanamido)octyl) carbamoyl)-4-((3S,5R)-3,4,5- trimethylpiperazin-1-yl)-[1,1′- biphenyl]-3-yl)-6-oxo-4- (trifluoromethyl)-1,6- dihydropyridine-3-carboxamide 

 

402 

N-(2′-fluoro-4′-((2-((S)-3-((2S,4R)-4- hydroxy-1-((R)-3-methyl-2-(3- methylisoxazol-5- yl)butanoyl)pyrrolidine-2- carboxamido)-3-(4-(4-methylthiazol-5- yl)phenyl)propanamido)ethyl) carbamoyl)-4-((3S,5R)-3,4,5- trimethylpiperazin-1-yl)-[1,1′- biphenyl]-3-yl)-6-oxo-4- (trifluoromethyl)-1,6- dihydropyridine-3-carboxamide 

 

403 

N-(2′-fluoro-4′-((3-((S)-3-((2S,4R)-4- hydroxy-1-((R)-3-methyl-2-(3- methylisoxazol-5- yl)butanoyl)pyrrolidine-2- carboxamido)-3-(4-(4-methylthiazol-5- yl)phenyl)propanamido)propyl) carbamoyl)-4-((3S,5R)-3,4,5- trimethylpiperazin-1-yl)-[1,1′- biphenyl]-3-yl)-6-oxo-4- (trifluoromethyl)-1,6- dihydropyridine-3-carboxamide 

 

404 

N-(2′-fluoro-4′-((4-((S)-3-((2S,4R)-4- hydroxy-1-((R)-3-methyl-2-(3- methylisoxazol-5- yl)butanoyl)pyrrolidine-2- carboxamido)-3-(4-(4-methylthiazol-5- yl)phenyl)propanamido)butyl) carbamoyl)-4-((3S,5R)-3,4,5- trimethylpiperazin-1-yl)-[1,1′- biphenyl]-3-yl)-6-oxo-4- (trifluoromethyl)-1,6- dihydropyridine-3-carboxamide 

 

405 

N-(2′-fluoro-4′-((5-((S)-3-((2S,4R)-4- hydroxy-1-((R)-3-methyl-2-(3- methylisoxazol-5- yl)butanoyl)pyrrolidine-2- carboxamido)-3-(4-(4-methylthiazol-5- yl)phenyl)propanamido)pentyl) carbamoyl)-4-((3S,5R)-3,4,5- trimethylpiperazin-1-yl)-[1,1′- biphenyl]-3-yl)-6-oxo-4- (trifluoromethyl)-1,6- dihydropyridine-3-carboxamide 

 

406 

N-(2′-fluoro-4′-((6-((S)-3-((2S,4R)-4- hydroxy-1-((R)-3-methyl-2-(3- methylisoxazol-5- yl)butanoyl)pyrrolidine-2- carboxamido)-3-(4-(4-methylthiazol-5- yl)phenyl)propanamido)hexyl) carbamoyl)-4-((3S,5R)-3,4,5- trimethylpiperazin-1-yl)-[1,1′- biphenyl]-3-yl)-6-oxo-4- (trifluoromethyl)-1,6- dihydropyridine-3-carboxamide 

 

407 

N-(2′-fluoro-4′-((7-((S)-3-((2S,4R)-4- hydroxy-1-((R)-3-methyl-2-(3- methylisoxazol-5- yl)butanoyl)pyrrolidine-2- carboxamido)-3-(4-(4-methylthiazol-5- yl)phenyl)propanamido)heptyl) carbamoyl)-4-((3S,5R)-3,4,5- trimethylpiperazin-1-yl)-[1,1′- biphenyl]-3-yl)-6-oxo-4- (trifluoromethyl)-1,6- dihydropyridine-3-carboxamide 

 

408 

N-(2′-fluoro-4′-((8-((S)-3-((2S,4R)-4- hydroxy-1-((R)-3-methyl-2-(3- methylisoxazol-5- yl)butanoyl)pyrrolidine-2- carboxamido)-3-(4-(4-methylthiazol-5- yl)phenyl)propanamido)octyl) carbamoyl)-4-((3S,5R)-3,4,5- trimethylpiperazin-1-yl)-[1,1′- biphenyl]-3-yl)-6-oxo-4- (trifluoromethyl)-1,6- dihydropyridine-3-carboxamide 

 

409 

N-(2′-fluoro-5′-((2-((S)-3-((2S,4R)-1- ((S)-2-(1-fluorocyclopropane-1- carboxamido)-3,3-dimethylbutanoyl)- 4-hydroxypyrrolidine-2- carboxamido)-3-(4-(4-methylthiazol-5- yl)phenyl)propanamido)ethyl) carbamoyl)-4-((3S,5R)-3,4,5- trimethylpiperazin-1-yl)-[1,1′- biphenyl]-3-yl)-6-oxo-4- (trifluoromethyl)-1,6- dihydropyridine-3-carboxamide 

 

416 

N-(2′-fluoro-4′-((2-((S)-3-((2S,4R)-1- ((S)-2-(1-fluorocyclopropane-1- carboxamido)-3,3-dimethylbutanoyl)- 4-hydroxypyrrolidine-2- carboxamido)-3-(4-(4-methylthiazol-5- yl)phenyl)propanamido)ethyl) carbamoyl)-4-((3S,5R)-3,4,5- trimethylpiperazin-1-yl)-[1,1′- biphenyl]-3-yl)-6-oxo-4- (trifluoromethyl)-1,6- dihydropyridine-3-carboxamide 

 

417 

N-(2′-fluoro-4′-((3-((S)-3-((2S,4R)-1- ((S)-2-(1-fluorocyclopropane-1- carboxamido)-3,3-dimethylbutanoyl)- 4-hydroxypyrrolidine-2- carboxamido)-3-(4-(4-methylthiazol-5- yl)phenyl)propanamido)propyl) carbamoyl)-4-((3S,5R)-3,4,5- trimethylpiperazin-1-yl)-[1,1′- biphenyl]-3-yl)-6-oxo-4- (trifluoromethyl)-1,6- dihydropyridine-3-carboxamide 

 

418 

N-(2′-fluoro-4′-((4-((S)-3-((2S,4R)-1- ((S)-2-(1-fluorocyclopropane-1- carboxamido)-3,3-dimethylbutanoyl)- 4-hydroxypyrrolidine-2- carboxamido)-3-(4-(4-methylthiazol-5- yl)phenyl)propanamido)butyl) carbamoyl)-4-((3S,5R)-3,4,5- trimethylpiperazin-1-yl)-[1,1′- biphenyl]-3-yl)-6-oxo-4- (trifluoromethyl)-1,6- dihydropyridine-3-carboxamide 

 

419 

N-(2′-fluoro-4′-((5-((S)-3-((2S,4R)-1- ((S)-2-(1-fluorocyclopropane-1- carboxamido)-3,3-dimethylbutanoyl)- 4-hydroxypyrrolidine-2- carboxamido)-3-(4-(4-methylthiazol-5- yl)phenyl)propanamido)pentyl) carbamoyl)-4-((3S,5R)-3,4,5- trimethylpiperazin-1-yl)-[1,1′- biphenyl]-3-yl)-6-oxo-4- (trifluoromethyl)-1,6- dihydropyridine-3-carboxamide 

 

420 

N-(2′-fluoro-4′-((6-((S)-3-((2S,4R)-1- ((S)-2-(1-fluorocyclopropane-1- carboxamido)-3,3-dimethylbutanoyl)- 4-hydroxypyrrolidine-2- carboxamido)-3-(4-(4-methylthiazol-5- yl)phenyl)propanamido)hexyl) carbamoyl)-4-((3S,5R)-3,4,5- trimethylpiperazin-1-yl)-[1,1′- biphenyl]-3-yl)-6-oxo-4- (trifluoromethyl)-1,6- dihydropyridine-3-carboxamide 

 

421 

N-(2′-fluoro-4′-((7-((S)-3-((2S,4R)-1- ((S)-2-(1-fluorocyclopropane-1- carboxamido)-3,3-dimethylbutanoyl)- 4-hydroxypyrrolidine-2- carboxamido)-3-(4-(4-methylthiazol-5- yl)phenyl)propanamido)heptyl) carbamoyl)-4-((3S,5R)-3,4,5- trimethylpiperazin-1-yl)-[1,1′- biphenyl]-3-yl)-6-oxo-4- (trifluoromethyl)-1,6- dihydropyridine-3-carboxamide 

 

422 

N-(2′-fluoro-4′-((8-((S)-3-((2S,4R)-1- ((S)-2-(1-fluorocyclopropane-1- carboxamido)-3,3-dimethylbutanoyl)- 4-hydroxypyrrolidine-2- carboxamido)-3-(4-(4-methylthiazol-5- yl)phenyl)propanamido)octyl) carbamoyl)-4-((3S,5R)-3,4,5- trimethylpiperazin-1-yl)-[1,1′- biphenyl]-3-yl)-6-oxo-4- (trifluoromethyl)-1,6- dihydropyridine-3-carboxamide 

 

423 

(3R,5S)-1-((S)-2-(2-(6-fluoro-3′-(6-oxo- 4-(trifluoromethyl)-1,6- dihydropyridine-3-carboxamido)-4′- ((3S,5R)-3,4,5-trimethylpiperazin-1- yl)-[1,1′-biphenyl]-3- carboxamido)acetamido)-3,3- dimethylbutanoyl)-5-((4-(4- methylthiazol-5- yl)benzyl)carbamoyl)pyrrolidin-3-yl acetate 

 

424 

(3R,5S)-1-((S)-2-(2-(6-fluoro-3′-(6-oxo- 4-(trifluoromethyl)-1,6- dihydropyridine-3-carboxamido)-4′- ((3S,5R)-3,4,5-trimethylpiperazin-1- yl)-[1,1′-biphenyl]-3- carboxamido)acetamido)-3,3- dimethylbutanoyl)-5-((4-(4- methylthiazol-5- yl)benzyl)carbamoyl)pyrrolidin-3-yl isobutyrate.