Patent ID: 11873488
Assignee: DICERNA PHARMACEUTICALS, INC.
Field: Biotechnology (Chemistry)
Classification: CPC C | IPC C

Claim 23:
24. The double-stranded nucleic acid inhibitor molecule of claim 23, wherein the bridge that connects the 2′-carbon and the 4′-carbon of the furanosyl is selected from the group consisting of:
a) 4′-CH2—O—N(R)-2′ and 4′-CH2—N(R)—O-2′, wherein R is H, C1-C12 alkyl, or a protecting group, including, for example, 4′-CH2—NH—O-2′ (also known as BNANC) or 4′-CH2—N(CH3)—O-2′ (also known as BNANC[NMe]);
b) 4′-CH2-2; 4′-(CH2)2-2; 4′-(CH2)3-2; 4′-(CH2)—O-2′ (also known as LNA); 4′-(CH2)—S-2; 4′-(CH2)2-O-2′ (also known as ENA); 4′-CH(CH3)—O-2′ (also known as cEt); and 4′-CH(CH2OCH3)—O-2′ (also known as cMOE), and analogs thereof;
c) 4′-C(CH3)(CH3)—O-2′ and analogs thereof
d) 4′-CH2—N(OCH3)-2′ and analogs thereof;
e) 4′-CH2—O—N(CH3)-2′ and analogs thereof;
f) 4′-CH2—C(H)(CH3)-2′ and analogs thereof; and
g) 4′-CH2—C(═CH2)-2′ and analogs thereof.