Patent ID: 11945797
Assignee: MISSION THERAPEUTICS LIMITED
Field: Organic fine chemistry (Chemistry)
Classification: CPC C  A | IPC C

Claim 13:
14. A compound, selected from the group consisting of:
3-(6-(3-cyanophenyl)-1H-benzo[d]imidazol-2-yl)pyrrolidine-1-carbonitrile;
4-(2-(1-cyanopyrrolidin-3-yl)-1H-benzo[d]imidazol-6-yl)benzamide;
4-(2-(1-cyanopyrrolidin-3-yl)-1H-benzo[d]imidazol-6-yl)-N-methylbenzamide;
3-(6-(2-fluoro-5-methylphenyl)-1H-benzo[d]imidazol-2-yl)pyrrolidine-1-carbonitrile;
3-(6-(6-isopropoxypyridin-3-yl)-1H-benzo[d]imidazol-2-yl)pyrrolidine-1-carbonitrile;
3-(6-(1-isobutyl-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-2-yl)pyrrolidine-1-carbonitrile;
3-(6-(pyridin-4-yl)-3H-imidazo[4,5-b]pyridin-2-yl)pyrrolidine-1-carbonitrile;
(S)-3-(6-(pyridin-4-yl)-3H-imidazo[4,5-b]pyridin-2-yl)pyrrolidine-1-carbonitrile;
(R)-3-(6-(pyridin-4-yl)-3H-imidazo[4,5-b]pyridin-2-yl)pyrrolidine-1-carbonitrile;
3-(6-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyrrolidine-1-carbonitrile;
3-(6-(4-cyanophenyl)-3H-imidazo[4,5-b]pyridin-2-yl)pyrrolidine-1-carbonitrile;
3-(6-(3-cyanophenyl)-3H-imidazo[4,5-b]pyridin-2-yl)pyrrolidine-1-carbonitrile;
3-(6-(6-methoxypyridin-3-yl)-3H-imidazo[4,5-b]pyridin-2-yl)pyrrolidine-1-carbonitrile;
3-(6-(1H-indazol-5-yl)-3H-imidazo[4,5-b]pyridin-2-yl)pyrrolidine-1-carbonitrile;
3-(6-(1H-pyrazol-4-yl)-3H-imidazo[4,5-b]pyridin-2-yl)pyrrolidine-1-carbonitrile;
3-(2-(1-cyanopyrrolidin-3-yl)-3H-imidazo[4,5-b]pyridin-6-yl)-N-methylbenzamide;
3-(6-(4-cyanophenyl)-3H-imidazo[4,5-b]pyridin-2-yl)pyrrolidine-1-carbonitrile: Enantiomer 1;
3-(6-(4-cyanophenyl)-3H-imidazo[4,5-b]pyridin-2-yl)pyrrolidine-1-carbonitrile: Enantiomer 2;
3-(2-(1-cyanopyrrolidin-3-yl)-3H-imidazo[4,5-b]pyridin-6-yl)-N-methylbenzamide: Enantiomer 1;
3-(2-(1-cyanopyrrolidin-3-yl)-3H-imidazo[4,5-b]pyridin-6-yl)-N-methylbenzamide: Enantiomer 2;
(S)-2-(6-phenyl-1H-benzo[d]imidazol-2-yl)pyrrolidine-1-carbonitrile;
3-(5-phenyl-1H-benzo[d]imidazol-2-yl)pyrrolidine-1-carbonitrile;
(S)-2-(1-methyl-5-phenyl-1H-benzo[d]imidazol-2-yl)pyrrolidine-1-carbonitrile;
3-(5-phenyl-3H-imidazo[4, 5-b]pyridin-2-yl)pyrrolidine-1-carbonitrile;
3-(7-phenyl-3H-imidazo[4, 5-b]pyridin-2-yl)pyrrolidine-1-carbonitrile;
3-(5-methyl-6-phenyl-3H-imidazo[4, 5-b]pyridin-2-yl)pyrrolidine-1-carbonitrile;
3-(7-methyl-6-phenyl-3H-imidazo[4, 5-b]pyridin-2-yl)pyrrolidine-1-carbonitrile;
3-(3-methyl-6-phenyl-3H-imidazo[4, 5-b]pyridin-2-yl)pyrrolidine-1-carbonitrile;
trans-3-methyl-4-(6-phenyl-3H-imidazo[4, 5-b] pyridin-2-yl)pyrrolidine-1-carbonitrile: Enantiomer 1;
trans-3-methyl-4-(6-phenyl-3H-imidazo [4, 5-b]pyridin-2-yl)pyrrolidine-1-carbonitrile: Enantiomer 2;
trans-3-methyl-4-(5-phenyl-1H-benzo[d]imidazol-2-yl)pyrrolidine-1-carbonitrile: Enantiomer 1;
(R)-3-(7-(4-methyl-1H-imidazol-1-yl)-1,6-di oxo-1,3,4,6-tetrahydro-2H-pyri do [1,2-a]pyrazin-2-yl)pyrrolidine-1-carbonitrile;
(S)-2-(1-cyanopyrrolidin-2-yl)-N-methyl-6-phenylbenzo[d]oxazole-4-carboxamide;
3-(7-phenylimidazo[1,2-a]pyridin-3-yl)pyrrolidine-1-carbonitrile;
3-(7-(3,5-dimethylisoxazol-4-yl)imidazo[1,2-a]pyridin-3-yl)pyrrolidine-1-carbonitrile;
(S)-2-(5-(3-cyanophenyl)benzo[d]oxazol-2-yl)pyrrolidine-1-carbonitrile;
(S)-6-(2-(1-cyanopyrrolidin-2-yl)benzo[d]oxazol-5-yl)picolinonitrile;
(S)-2-(6-(3-cyanophenyl)benzo[d]oxazol-2-yl)pyrrolidine-1-carbonitrile;
(S)-2-(5-(3-ethylphenyl)benzo[d]oxazol-2-yl)pyrrolidine-1-carbonitrile;
(S)-2-(6-(3-ethylphenyl)benzo[d]oxazol-2-yl)pyrrolidine-1-carbonitrile;
(S)-2-(1-cyanopyrrolidin-2-yl)-6-(3-ethylphenyl)-N-methylbenzo[d]oxazole-4-carboxamide;
(S)-6-(2-(1-cyanopyrrolidin-2-yl)benzo[d]oxazol-6-yl)picolinonitrile;
(S)-2-(5-(3-(trifluoromethoxy)phenyl)benzo[d]oxazol-2-yl)pyrrolidine-1-carbonitrile;
(S)-2-(5-(3-methyl-1H-indazol-6-yl)benzo[d]oxazol-2-yl)pyrrolidine-1-carbonitrile;
(S)-2-(5-(1-methyl-1H-indazol-5-yl)benzo[d]oxazol-2-yl)pyrrolidine-1-carbonitrile;
(S)-2-(5-(3-nitrophenyl)benzo[d]oxazol-2-yl)pyrrolidine-1-carbonitrile;
(S)-2-(5-(3-cyano-2-fluorophenyl)benzo[d]oxazol-2-yl)pyrrolidine-1-carbonitrile; and
(S)-2-(5-(3-cyano-5-fluorophenyl)benzo[d]oxazol-2-yl)pyrrolidine-1-carbonitrile;
a tautomer thereof, or a pharmaceutically acceptable salt of said compound or tautomer.