Patent ID: 11926666
Assignee: AMGEN RESEARCH (MUNICH) GMBH
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A method for treating or ameliorating a tumor or cancer, the method comprising administering to a subject in need thereof a bispecific single chain antibody construct comprising:
a first human binding domain which binds to human CDH3 on the surface of a target cell; and
a second binding domain which binds to human CD3 on the surface of a T cell,
wherein the first binding domain comprises a VH region and a VL region selected from the group consisting of:
a) a VH region comprising a CDR-H1 comprising the amino acid sequence of SEQ ID NO: 169, a CDR-H2 comprising the amino acid sequence of SEQ ID NO: 170, and a CDR-H3 comprising the amino acid sequence of SEQ ID NO: 171, and a VL region comprising a CDR-L1 comprising the amino acid sequence of SEQ ID NO: 172, a CDR-L2 comprising the amino acid sequence of SEQ ID NO: 173, and a CDR-L3 comprising the amino acid sequence of SEQ ID NO: 174;
b) a VH region comprising a CDR-H1 comprising the amino acid sequence of SEQ ID NO: 279, a CDR-H2 comprising the amino acid sequence of SEQ ID NO: 280, and a CDR-H3 comprising the amino acid sequence of SEQ ID NO: 281, and a VL region comprising a CDR-L1 comprising the amino acid sequence of SEQ ID NO: 282, a CDR-L2 comprising the amino acid sequence of SEQ ID NO: 283, and a CDR-L3 comprising the amino acid sequence of SEQ ID NO: 284;
c) a VH region comprising a CDR-H1 comprising the amino acid sequence of SEQ ID NO: 289, a CDR-H2 comprising the amino acid sequence of SEQ ID NO: 290, and a CDR-H3 comprising the amino acid sequence of SEQ ID NO: 291, and a VL region comprising a CDR-L1 comprising the amino acid sequence of SEQ ID NO: 292, a CDR-L2 comprising the amino acid sequence of SEQ ID NO: 293, and a CDR-L3 comprising the amino acid sequence of SEQ ID NO: 294;
d) a VH region comprising a CDR-H1 comprising the amino acid sequence of SEQ ID NO: 299, a CDR-H2 comprising the amino acid sequence of SEQ ID NO: 300, and a CDR-H3 comprising the amino acid sequence of SEQ ID NO: 301, and a VL region comprising a CDR-L1 comprising the amino acid sequence of SEQ ID NO: 302, a CDR-L2 comprising the amino acid sequence of SEQ ID NO: 303, and a CDR-L3 comprising the amino acid sequence of SEQ ID NO: 304; and
e) a VH region comprising a CDR-H1 comprising the amino acid sequence of SEQ ID NO: 309, a CDR-H2 comprising the amino acid sequence of SEQ ID NO: 310, and a CDR-H3 comprising the amino acid sequence of SEQ ID NO: 311, and a VL region comprising a CDR-L1 comprising the amino acid sequence of SEQ ID NO: 312, a CDR-L2 comprising the amino acid sequence of SEQ ID NO: 313, and a CDR-L3 comprising the amino acid sequence of SEQ ID NO: 314.