Patent ID: 11945856
Assignee: 35PHARMA INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 26:
27. A transforming growth factor beta (TGFβ) superfamily ligand binding agent comprising a first polypeptide and a second polypeptide, wherein each of the first and second polypeptide comprises:
(a) an Activin receptor type IIB (ActRIIB) ectodomain (ECD) variant comprising the amino acid sequence that is at least 85% identical to the amino acid sequence of SEQ ID NO: 2, wherein the ActRIIB-ECD variant comprises F58Q substitution relative to the human wild type ActRIIB-ECD of SEQ ID NO: 2;
(b) a peptide linker comprising at least 10 amino acids; and
(c) an immunoglobulin (Ig) Fc domain monomer,
wherein the first and second polypeptides are linked by at least one disulfide bond between the Ig Fc domain monomer of the first polypeptide and the Ig Fc domain monomer of the second polypeptide.