Patent ID: 11918572
Assignee: REBEL MEDICINE INC
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 3:
4. A method of manufacturing the pharmaceutical composition of claim 1, the method comprising:
a) mixing the bupivacaine, medium-chain triglyceride oil, castor oil and tristearin, anesthetic agent under stirring and heating at a temperature above 25° C. and up to 150° C. to form a mixture;
b) placing the mixture in a sealed syringe and cooling the mixture to form the pharmaceutical composition; and
c) sterilizing the pharmaceutical composition, wherein sterilization occurs after the pharmaceutical composition placed in the sealed syringe, wherein sterilization comprises gamma irradiation, electron beam irradiation, x-ray irradiation, heat sterilization, steam sterilization, or a combination thereof.