Patent ID: 11944681
Assignee: UNIVERSITY OF MARYLAND
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 0:
1. A recombinant antibody or fragment thereof comprising: a heavy chain variable region comprising a heavy chain complementarity determining region (HCDR)1, a HCDR2, and a HCDR3 comprising amino acids at positions 26-33, 51-60 and 99-121 of SEQ ID NO: 230, SEQ ID NO: 240 or SEQ ID NO: 241, respectively and wherein the amino acid sequence of the heavy chain variable region outside of HCDR1, HCDR2, and HCDR3 has an overall sequence identity of at least 90% to SEQ ID NO: 230, SEQ ID NO: 240, or SEQ ID NO: 241; and a light chain variable region comprising a light chain complementarity determining region (LCDR)1, a LCDR2, and a LCDR3, comprising amino acids at positions 27-32, 50-52 and 89-99 of SEQ ID NO: 253, SEQ ID NO: 255 or SEQ ID NO: 261 respectively, and wherein the amino acid sequence of the light chain variable region outside of LCDR1, LCDR2, and LCDR3 has an overall sequence identity of at least 90% to SEQ ID NO: 253, SEQ ID NO: 255, or SEQ ID NO: 261, and wherein the antibody or fragment thereof binds gp41 MPER of HIV-1 envelope.