Patent ID: 11867627
Assignee: WASHINGTON UNIVERSITY
Field: Measurement (Instruments)
Classification: CPC G  A | IPC A  G

Claim 15:
16. A compact diffuse optical tomography (DOT) system for generating a functional image of a lesion region of a subject, comprising:
a source subsystem including:
a plurality of laser diodes configured to generate near-infrared (NIR) optical waves; and
a laser diode driver board configured to drive the plurality of laser diodes, wherein the laser diode driver board includes one or more optical switches configured to multiplex the optical waves generated by the plurality of laser diodes;

a probe configured to emit the optical waves generated by the source subsystem toward the lesion region and configured to detect optical waves reflected by the lesion region;
a detection subsystem including:
a miniaturized detection board including a photomultiplier tube (PMT) having a plurality of channels and configured to convert the optical waves detected by the probe to electrical signals; and
a miniaturized data acquisition board configured to convert electrical signals outputted by the miniaturized detection board to digital signals, and to output the digital signals from the detection subsystem; and

a computing device separate from the source subsystem, the probe, and the detection subsystem, the computing device configured to:
receive the digital signals sent from the detection subsystem, the digital signals comprising lesion functional data from the lesion region of the subject and reference functional data from a healthy tissue region of the subject;
reconstruct the functional image of the lesion region based on the digital signals by:
transforming the lesion functional data and the reference functional data to produce perturbation data;
generating a preliminary estimate of the functional image by applying a truncated pseudoinverse matrix of a weight matrix to the perturbation data; and
generating the functional image by iteratively optimizing successive estimates of the functional image regularized by the preliminary estimate of the functional image weighted by a regularization parameter; and

display the functional image.