Patent ID: 11970463
Assignee: MITSUBISHI TANABE PHARMA CORPORATION
Field: Organic fine chemistry (Chemistry)
Classification: CPC C | IPC C

Claim 14:
15. The compound of claim 1, wherein the compound is selected from:
(2S)-3-[[4-[2-hydroxy-4-(trifluoromethyl)phenyl]phthalazin-1-yl]amino]propane-1,2-diol;
(2R)-3-[[4-[2-hydroxy-4-(trifluoromethyl)phenyl]phthalazin-1-yl]amino]propane-1,2-diol;
(2S)-3-[[4-(4-chloro-3-fluoro-2-hydroxy-phenyl)phthalazin-1-yl]amino]propane-1,2-diol;
(2R)-3-[[4-(4-chloro-3-fluoro-2-hydroxy-phenyl)phthalazin-1-yl]amino]propane-1,2-diol;
(2S)-3-[[4-(4,5-difluoro-2-hydroxy-phenyl)phthalazin-1-yl]amino]propane-1,2-diol;
(2R)-3-[[4-(4,5-difluoro-2-hydroxy-phenyl)phthalazin-1-yl]amino]propane-1,2-diol;
(2S)-3-[[4-(2-fluoro-6-hydroxy-phenyl)phthalazin-1-yl]amino]propane-1,2-diol;
(2R)-3-[[4-(2-fluoro-6-hydroxy-phenyl)phthalazin-1-yl]amino]propane-1,2-diol;
(2S)-3-[[4-(4-chloro-2-hydroxy-phenyl)phthalazin-1-yl]amino]propane-1,2-diol;
(2R)-3-[[4-(4-chloro-2-hydroxy-phenyl)phthalazin-1-yl]amino]propane-1,2-diol;
(2S)-3-[[4-[2-hydroxy-4-(trifluoromethoxy)phenyl]phthalazin-1-yl]amino]propane-1,2-diol;
(2R)-3-[[4-[2-hydroxy-4-(trifluoromethoxy)phenyl]phthalazin-1-yl]amino]propane-1,2-diol;
(2S)-3-[[4-[2-fluoro-6-hydroxy-4-(trifluoromethyl)phenyl]phthalazin-1-yl]amino]propane-1,2-diol;
(2R)-3-[[4-[2-fluoro-6-hydroxy-4-(trifluoromethyl)phenyl]phthalazin-1-yl]amino]propane-1,2-diol;
(2S)-3-[[4-(2,4-difluoro-6-hydroxy-phenyl)phthalazin-1-yl]amino]propane-1,2-diol;
(2R)-3-[[4-(2,4-difluoro-6-hydroxy-phenyl)phthalazin-1-yl]amino]propane-1,2-diol;
(2S)-3-[[4-(4-chloro-2-fluoro-6-hydroxy-phenyl)phthalazin-1-yl]amino]propane-1,2-diol;
(2R)-3-[[4-(4-chloro-2-fluoro-6-hydroxy-phenyl)phthalazin-1-yl]amino]propane-1,2-diol;
(2S)-3-[[4-(2-chloro-6-hydroxy-phenyl)phthalazin-1-yl]amino]propane-1,2-diol;
(2R)-3-[[4-(2-chloro-6-hydroxy-phenyl)phthalazin-1-yl]amino]propane-1,2-diol;
(2S)-3-[[4-(2-hydroxy-4-methyl-phenyl)phthalazin-1-yl]amino]propane-1,2-diol;
(2R)-3-[[4-(2-hydroxy-4-methyl-phenyl)phthalazin-1-yl]amino]propane-1,2-diol;
(2S)-3-[[4-(2-hydroxy-5-methyl-phenyl)phthalazin-1-yl]amino]propane-1,2-diol;
(2R)-3-[[4-(2-hydroxy-5-methyl-phenyl)phthalazin-1-yl]amino]propane-1,2-diol;
(2S)-3-[[4-[2-hydroxy-4-(trifluoromethyl)phenyl]-7-methyl-phthalazin-1-yl]amino]propane-1,2-diol;
(2R)-3-[[4-[2-hydroxy-4-(trifluoromethyl)phenyl]-7-methyl-phthalazin-1-yl]amino]propane-1,2-diol;
(2S)-3-[[4-[2-hydroxy-4-(trifluoromethyl)phenyl]-6-methyl-phthalazin-1-yl]amino]propane-1,2-diol;
(2R)-3-[[4-[2-hydroxy-4-(trifluoromethyl)phenyl]-6-methyl-phthalazin-1-yl]amino]propane-1,2-diol;
2-[4-[[(1R,2S)-2-hydroxycyclohexyl]amino]phthalazin-1-yl]-5-(trifluoromethyl)phenol;
2-[4-[[(1R,2R)-2-hydroxycyclohexyl]amino]phthalazin-1-yl]-5-(trifluoromethyl)phenol;
2-[4-[[(1S,2R)-2-hydroxycyclohexyl]amino]phthalazin-1-yl]-5-(trifluoromethyl)phenol;
2-[4-[[(1S,2S)-2-hydroxycyclohexyl]amino]phthalazin-1-yl]-5-(trifluoromethyl)phenol;
4-fluoro-2-[4-[[(1R,2R)-2-hydroxycyclohexyl]amino]pyrido[3,4-d]pyridazin-1-yl]-5-(trifluoromethyl)phenol;
4-fluoro-2-[4-[[(1S,2R)-2-hydroxycyclohexyl]amino]pyrido[3,4-d]pyridazin-1-yl]-5-(trifluoromethyl)phenol;
4-fluoro-2-[4-[[(1R,2S)-2-hydroxycyclohexyl]amino]pyrido[3,4-d]pyridazin-1-yl]-5-(trifluoromethyl)phenol;
4-fluoro-2-[4-[[(1S,2S)-2-hydroxycyclohexyl]amino]pyrido[3,4-d]pyridazin-1-yl]-5-(trifluoromethyl)phenol;
3-fluoro-2-[4-[[(1R,2R)-2-hydroxycyclohexyl]amino]pyrido[3,4-d]pyridazin-1-yl]-5-(trifluoromethyl)phenol;
3-fluoro-2-[4-[[(1R,2S)-2-hydroxycyclohexyl]amino]pyrido[3,4-d]pyridazin-1-yl]-5-(trifluoromethyl)phenol;
3-fluoro-2-[4-[[(1S,2R)-2-hydroxycyclohexyl]amino]pyrido[3,4-d]pyridazin-1-yl]-5-(trifluoromethyl)phenol;
3-fluoro-2-[4-[[(1S,2S)-2-hydroxycyclohexyl]amino]pyrido[3,4-d]pyridazin-1-yl]-5-(trifluoromethyl)phenol;
2-[4-[[(1R,2R)-2-hydroxycyclohexyl]amino]pyrido[3,4-d]pyridazin-1-yl]-5-(trifluoromethoxy)phenol;
2-[4-[[(1S,2S)-2-hydroxycyclohexyl]amino]pyrido[3,4-d]pyridazin-1-yl]-5-(trifluoromethoxy)phenol;
2-[4-[[(1R,2S)-2-hydroxycyclohexyl]amino]pyrido[3,4-d]pyridazin-1-yl]-5-(trifluoromethoxy)phenol;
2-[4-[[(1S,2R)-2-hydroxycyclohexyl]amino]pyrido[3,4-d]pyridazin-1-yl]-5-(trifluoromethoxy)phenol;
5-chloro-3-fluoro-2-[4-[[(1R,2R)-2-hydroxycyclohexyl]amino]pyrido[3,4-d]pyridazin-1-yl]phenol;
5-chloro-3-fluoro-2-[4-[[(1S,2S)-2-hydroxycyclohexyl]amino]pyrido[3,4-d]pyridazin-1-yl]phenol;
5-chloro-3-fluoro-2-[4-[[(1R,2S)-2-hydroxycyclohexyl]amino]pyrido[3,4-d]pyridazin-1-yl]phenol;
5-chloro-3-fluoro-2-[4-[[(1S,2R)-2-hydroxycyclohexyl]amino]pyrido[3,4-d]pyridazin-1-yl]phenol;
5-chloro-2-[4-[[(1R,2R)-2-hydroxycyclohexyl]amino]pyrido[3,4-d]pyridazin-1-yl]phenol;
5-chloro-2-[4-[[(1S,2S)-2-hydroxycyclohexyl]amino]pyrido[3,4-d]pyridazin-1-yl]phenol;
5-chloro-2-[4-[[(1R,2S)-2-hydroxycyclohexyl]amino]pyrido[3,4-d]pyridazin-1-yl]phenol;
5-chloro-2-[4-[[(1S,2R)-2-hydroxycyclohexyl]amino]pyrido[3,4-d]pyridazin-1-yl]phenol;
5-fluoro-2-(4-(((1R,2R)-2-hydroxycyclohexyl)amino)pyrido[3,4-d]pyridazin-1-yl)phenol;
5-fluoro-2-(4-(((1S,2S)-2-hydroxycyclohexyl)amino)pyrido[3,4-d]pyridazin-1-yl)phenol;
5-fluoro-2-(4-(((1S,2R)-2-hydroxycyclohexyl)amino)pyrido[3,4-d]pyridazin-1-yl)phenol;
5-fluoro-2-(4-(((1R,2S)-2-hydroxycyclohexyl)amino)pyrido[3,4-d]pyridazin-1-yl)phenol;
3-fluoro-2-(4-(((1R,2R)-2-hydroxycyclohexyl)amino)pyrido[3,4-d]pyridazin-1-yl)phenol;
3-fluoro-2-(4-(((1S,2S)-2-hydroxycyclohexyl)amino)pyrido[3,4-d]pyridazin-1-yl)phenol;
3-fluoro-2-(4-(((1S,2R)-2-hydroxycyclohexyl)amino)pyrido[3,4-d]pyridazin-1-yl)phenol;
3-fluoro-2-(4-(((1R,2S)-2-hydroxycyclohexyl)amino)pyrido[3,4-d]pyridazin-1-yl)phenol;
3-fluoro-2-(1-(((1R,2R)-2-hydroxycyclohexyl)amino)pyrido[3,4-d]pyridazin-4-yl)phenol;
3-fluoro-2-(1-(((1S,2S)-2-hydroxycyclohexyl)amino)pyrido[3,4-d]pyridazin-4-yl)phenol;
3-fluoro-2-(1-(((1S,2R)-2-hydroxycyclohexyl)amino)pyrido[3,4-d]pyridazin-4-yl)phenol;
3-fluoro-2-(1-(((1R,2S)-2-hydroxycyclohexyl)amino)pyrido[3,4-d]pyridazin-4-yl)phenol;
5-fluoro-2-(1-(((1R,2R)-2-hydroxycyclohexyl)amino)pyrido[3,4-d]pyridazin-4-yl)phenol;
5-fluoro-2-(1-(((1S,2S)-2-hydroxycyclohexyl)amino)pyrido[3,4-d]pyridazin-4-yl)phenol;
5-fluoro-2-(1-(((1R,2S)-2-hydroxycyclohexyl)amino)pyrido[3,4-d]pyridazin-4-yl)phenol;
5-fluoro-2-(1-(((1S,2R)-2-hydroxycyclohexyl)amino)pyrido[3,4-d]pyridazin-4-yl)phenol;
2-[4-[[(1S,2R)-2-hydroxycyclohexyl]amino]pyrido[3,4-d]pyridazin-1-yl]-5-(trifluoromethyl)phenol;
2-[4-[[(1R,2S)-2-hydroxycyclohexyl]amino]pyrido[3,4-d]pyridazin-1-yl]-5-(trifluoromethyl)phenol;
2-[4-[[(1S,2S)-2-hydroxycyclohexyl]amino]pyrido[3,4-d]pyridazin-1-yl]-5-(trifluoromethyl)phenol;
2-[4-[[(1R,2R)-2-hydroxycyclohexyl]amino]pyrido[3,4-d]pyridazin-1-yl]-5-(trifluoromethyl)phenol;
(2S)-3-[[1-[2-hydroxy-4-(trifluoromethyl)phenyl]pyrido[3,4-d]pyridazin-4-yl]amino]propane-1,2-diol;
(2R)-3-[[1-[2-hydroxy-4-(trifluoromethyl)phenyl]pyrido[3,4-d]pyridazin-4-yl]amino]propane-1,2-diol;
(S)-3-((4-(2-hydroxy-4-(trifluoromethyl)phenyl)phthalazin-1-yl)amino)-2-methylpropane-1,2-diol; and
(R)-3-((4-(2-hydroxy-4-(trifluoromethyl)phenyl)phthalazin-1-yl)amino)-2-methylpropane-1,2-diol;
or a pharmaceutically acceptable salt thereof.