Patent ID: 11969506
Assignee: OREGON STATE UNIVERSITY
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 0:
1. A nanoparticle composition comprising a lipid component comprising
an ionizable lipid,
a phospholipid,
a cholesterol, and
a cholesterol derivative; wherein the cholesterol derivative is
(a) β-sitosterol or campesterol; or
(b) a compound of the formula, , or a salt thereof, wherein Ra is C1-6 alkyl optionally substituted with OH or halo; Rb is C1-6 alkyl optionally substituted with OH or halo; and D1 is H or F,, wherein the molar ratio between the cholesterol and cholesterol derivative is between about 1:100 and 100:1.