Patent ID: 11884725
Assignee: AMPSOURCE BIOPHARMA SHANGHAI INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 5:
6. The antibody or the antigen-binding fragment thereof according to claim 1, comprising:
(a) a heavy chain variable region (VH), comprising an amino acid sequence selected from:
(i) a sequence as shown by any one of SEQ ID NOs: 1, 3, 5, 7, 9 and 11;
(ii) a sequence with one or more substitutions, deletions or additions relative to the sequence as shown by any one of SEQ ID NOs: 1, 3, 5, 7, 9 and 11; or
(iii) a sequence with at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity relative to the sequence as shown by any one of SEQ ID NOs: 1, 3, 5, 7, 9 and 11; and/or
(b) a light chain variable region (VL), comprising an amino acid sequence selected from:
(iv) a sequence as shown by any one of SEQ ID NOs: 2, 4, 6, 8, 10 and 12;
(v) a sequence with one or more substitutions, deletions or additions relative to the sequence as shown by any one of SEQ ID NOs: 2, 4, 6, 8, 10 and 12; or
(vi) a sequence with at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% sequence identity relative to the sequence as shown by any one of SEQ ID NOs: 2, 4, 6, 8, 10 and 12;
wherein, the substitutions in (ii) or (v) are conservative substitutions.