Patent ID: 11873496
Assignee: WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH
Field: Measurement (Instruments)
Classification: CPC C  G | IPC C  G

Claim 0:
1. A method of decreasing expression of one or more genes in a cell, comprising contacting the cell with a composition for decreasing binding of Yin Yang 1 (YY1) to a YY1 binding site, wherein the composition comprises a site-specific DNA binding domain (DBD) that binds a promoter or an enhancer of the one or more genes and an effector domain having DNA methylation activity, or one or more nucleic acids encoding the site-specific DBD and/or effector domain, and wherein the YY1 binding site is in the promoter or the enhancer of the one or more genes, thereby decreasing expression of the one or more genes.