Patent ID: 11858976
Assignee: TRUSTEES OF DARTMOUTH COLLEGE
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A nucleic acid construct which provides for the expression of a chimeric receptor which comprises:
a first nucleic acid sequence encoding a promoter operably linked to a second nucleic acid sequence encoding a chimeric receptor comprising a C-type lectin-like natural killer cell receptor, fused to a nucleic acid encoding an immune signaling receptor containing an immunoreceptor tyrosine-based activation motif of SEQ ID NO: 1,
wherein the C-type lectin-like NK cell type II receptor is Dectin-1, Mast cell function-associated antigen, HNKR-P1A, LLT1, CD69, CD69 homolog, CD72, CD94, KLRF1, CLEC-1, CLEC-2, NKG2D, NKG2C, NKG2A, or NKG2E.