Patent ID: 11891402
Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A  G | IPC A  C

Claim 0:
1. A human K-Ras protein having a cysteine at residue 12, wherein said cysteine is covalently bonded to a compound, wherein said compound has the formula

R1-L1-L2-L3-E,

wherein
R1 is substituted or unsubstituted fused ring aryl or substituted or unsubstituted fused ring heteroaryl;
L1 is a substituted or unsubstituted heteroarylene;
L2 is a bond;
L3 is a substituted or unsubstituted spirocyclic linker; and, prior to covalently bonding to the cysteine 12,,