Patent ID: 11946077
Assignee: EMENDOBIO INC.
Field: Biotechnology (Chemistry)
Classification: CPC C | IPC C

Claim 3:
4. The composition of claim 3, wherein the CRISPR nuclease comprises a sequence having at least 90% identity to the amino acid sequence set forth in SEQ ID NO: 5 and
i) at least one RNA molecule is a CRISPR RNA (crRNA) molecule comprising a guide sequence portion and a sequence selected from the group consisting of SEQ ID NOs: 63, 64, 71-73, and 81-83; and further comprising a transactivating CRISPR RNA (tracrRNA) molecule comprising a sequence set forth in the group consisting of SEQ ID NOs: 65-69, 74-79, and 84-89; or
ii) at least one RNA molecule is a single-guide RNA (sgRNA) molecule comprising a guide sequence portion and a sequence selected from the group consisting of SEQ ID NOs: 63-90.