Patent ID: 11866446
Assignee: VERTEX PHARMACEUTICALS INCORPORATED
Field: Organic fine chemistry (Chemistry)
Classification: CPC C  A | IPC C

Claim 27:
28. The compound, tautomer, deuterated derivative, or pharmaceutically acceptable salt according to claim 1, wherein Ra, for each occurrence, is independently selected from F, Cl, Br, cyano, C1-C6 alkyl, C1-C2 alkoxy, C1-C2 haloalkyl,, C(═O)NRhRi, —NRhRi, —NRhC(═O)Rk, —ORk, —[O(CH2)q]rO(C1-C2 alkyl), —S(═O)2Rk, —S(═O)2NRhRi, cyclopropyl, cyclobutyl, 5-membered heterocyclyl, phenyl, and 6-membered heteroaryl; wherein:
the C1-C6 alkyl of Ra is optionally substituted with 1 to 3 groups independently selected from cyano, —C(═O)NRhRi, —ORk, and cyclopropyl;
the cyclopropyl, the cyclobutyl, the 5 to 6-membered heterocyclyl, the phenyl, and the 5 to 6-membered heteroaryl of Ra are each optionally substituted with 1 to 3 groups independently selected from halogen, —CH3, —OH, and —OCH3; wherein:
Rh and Ri, for each occurrence, are each independently selected from hydrogen, —CH3, and cyclopropyl; wherein:
the —CH3 of any one of Rh and Ri is optionally substituted with 1 to 3 groups independently selected from F, Cl, and —OH;

Rk, for each occurrence, is each independently selected from hydrogen and

CH3; and
q and r are each an integer selected from 1 and 2.