Patent ID: 11945836
Assignee: SAGE THERAPEUTICS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 1:
2. A method of inducing sedation and/or anesthesia in a subject in need thereof, comprising administering to the subject an effective amount of a compound of Formula (I):, or a pharmaceutically acceptable salt thereof;
wherein:
Ring A is substituted or unsubstituted aryl or heteroaryl, wherein A is linked through a carbon atom;
R1 is hydrogen, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C2-6 alkenyl, or substituted or unsubstituted C3-6 carbocyclyl;
R2 is hydrogen, halogen, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C2-6 alkenyl, substituted or unsubstituted C2-6 alkynyl, substituted or unsubstituted C3-6 carbocyclyl, —N(RA)(RB), or —ORA2, wherein each of RA and RB is independently hydrogen, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C2-6 alkenyl, substituted or unsubstituted C2-6 alkynyl, substituted or unsubstituted C3-6 carbocyclyl, or substituted or unsubstituted heterocyclyl, or RA and RB, together with the nitrogen atom to which they are attached form a ring; RA2 is hydrogen or substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C2-6 alkenyl, substituted or unsubstituted C2-6 alkynyl, or substituted or unsubstituted C3-6 carbocyclyl;
R3a is hydrogen, —N(RA)(RB), or —ORA3, wherein RA3 is hydrogen, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C2-6 alkenyl, substituted or unsubstituted C2-6 alkynyl, or substituted or unsubstituted C3-6 carbocyclyl, and R3b is hydrogen or —N(RA)C(O)RA3; or
R3a and R3b are joined to form an oxo (═O) group;
R4 is hydrogen or halogen;
R5 is hydrogen, unsubstituted C1-6 alkyl, or —CH2ORA5, wherein RA5 is hydrogen, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C2-6 alkenyl, substituted or unsubstituted C2-6 alkynyl, or substituted or unsubstituted C3-6 carbocyclyl;
R6 is absent or hydrogen; and
 represents a single or double bond, wherein
when one of  is a double bond, the other  is a single bond; and
when one of the  is a double bond, R6 is absent.