Patent ID: 11858884
Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 29:
30. A method for delivering a nucleic acid to a cell of a subject, the method comprising administering to said subject said nucleic acid, wherein said nucleic acid is formulated with a nanoparticle comprising a compound having the structure of Formula (I):

Core-Repeating Unit-Terminating Group  (I),

wherein the core is linked to four or five repeating units and each repeating unit is linked to a nitrogen of the core, wherein the core has the following structure:, wherein the repeating unit is a degradable diacyl, having the formula:, wherein in Formula (VII),
A1 and A2 are each —O—;
Y3 is —CH2CH2—;
R9 is —CH3; and
the terminating group is selected from the group consisting of:, wherein a protein expressed by said nucleic acid is detected in a cell of the subject following said administration of said nucleic acid formulated with said nanoparticle.