Patent ID: 11939331
Assignee: INCYTE CORPORATION
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 34:
35. The compound of claim 1, wherein the compound is selected from:
2-(2,6-Dichlorophenyl)-9-(1-(2-hydroxyethyl)-1H-pyrazol-4-yl)imidazo [2,1-f][1,6]naphthyridine-3-carboxamide;
2-(2,6-Dichlorophenyl)-9-(1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl)imidazo[2,1-f][1,6]naphthyridine-3-carboxamide;
9-(1-(1-Amino-2-methyl-1-oxopropan-2-yl)-1H-pyrazol-4-yl)-2-(2,6-dichlorophenyl)imidazo[2,1-f][1,6]naphthyridine-3-carboxamide;
2-(2,6-Dichlorophenyl)-9-(4-(morpholine-4-carbonyl)phenyl)imidazo[2,1-f][1,6]naphthyridine-3-carboxamide;
2-(2,6-Dichlorophenyl)-9-(1H-pyrazol-4-yl)imidazo[2,1-f][1,6]naphthyridine-3-carboxamide;
9-(1-(1-Cyanopropan-2-yl)-1H-pyrazol-4-yl)-2-(2,6-dichlorophenyl)imidazo[2,1-f][1,6]naphthyridine-3-carboxamide;
2-(2,6-Dichlorophenyl)-9-(1-(2-hydroxybutyl)-1H-pyrazol-4-yl)imidazo[2,1-f][1,6]naphthyridine-3-carboxamide;
2-(2,6-Dichlorophenyl)-9-(1-((4-fluorotetrahydro-2H-pyran-4-yl)methyl)-1H-pyrazol-4-yl)imidazo[2,1-f][1,6]naphthyridine-3-carboxamide;
9-(1-((5-Cyanopyridin-3-yl)methyl)-1H-pyrazol-4-yl)-2-(2,6-dichlorophenyl)imidazo[2,1-f][1,6]naphthyridine-3-carboxamide;
9-(1-((2-Cyanopyridin-4-yl)methyl)-1H-pyrazol-4-yl)-2-(2,6-dichlorophenyl)imidazo[2,1-f][1,6]naphthyridine-3-carboxamide;
2-(2,6-Dichlorophenyl)-9-(1-(pyrimidin-4-ylmethyl)-1H-pyrazol-4-yl)imidazo[2,1-f][1,6]naphthyridine-3-carboxamide;
9-(1-(1-(2-Cyanopyridin-4-yl)ethyl)-1H-pyrazol-4-yl)-2-(2,6-dichlorophenyl)imidazo[2,1-f][1,6]naphthyridine-3-carboxamide;
2-(2,6-Dichlorophenyl)-9-(4-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)phenyl)imidazo[2,1-f][1,6]naphthyridine-3-carboxamide;
2-(2,6-Dichlorophenyl)-9-(4-(1,1-dioxidothiomorpholino)phenyl)imidazo[2,1-f][1,6]naphthyridine-3-carboxamide;
2-(2,6-Dichlorophenyl)-9-(1-(pyrimidin-2-ylmethyl)-1H-pyrazol-4-yl)imidazo[2,1-f][1,6]naphthyridine-3-carboxamide;
9-(1-((6-Cyanopyridin-2-yl)methyl)-1H-pyrazol-4-yl)-2-(2,6-dichlorophenyl)imidazo[2,1-f][1,6]naphthyridine-3-carboxamide;
9-(4-(4-Acetylpiperazin-1-yl)phenyl)-2-(2,6-dichlorophenyl)imidazo[2,1-f][1,6]naphthyridine-3-carboxamide;
2-(2,6-Dichlorophenyl)-9-(4-(4-(2-hydroxyacetyl)piperazin-1-yl)phenyl)imidazo[2,1-f][1,6]naphthyridine-3-carboxamide;
9-(4-((4-Acetylpiperazin-1-yl)methyl)phenyl)-2-(2,6-dichlorophenyl)imidazo[2,1-f][1,6]naphthyridine-3-carboxamide;
2-(2,6-Dichlorophenyl)-9-(4-((4-(2-hydroxyacetyl)piperazin-1-yl)methyl)phenyl)imidazo[2,1-f][1,6]naphthyridine-3-carboxamide;
2-(2,6-Dichlorophenyl)-9-(4-(4-methylpiperazin-1-yl)phenyl)imidazo[2,1-f][1,6]naphthyridine-3-carboxamide;
9-(4-((1S,4S)-2-Oxa-5-azabicyclo[2.2.1]heptane-5-carbonyl)phenyl)-2-(2,6-dichlorophenyl)imidazo[2,1-f][1,6]naphthyridine-3-carboxamide;
9-(1-(Cyanomethyl)-1H-pyrazol-4-yl)-2-(2,6-dichlorophenyl)imidazo[2,1-f][1,6]naphthyridine-3-carboxamide;
2-(2,6-Dichlorophenyl)-9-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)imidazo[2,1-f][1,6]naphthyridine-3-carboxamide;
9-(1-Benzyl-1H-pyrazol-4-yl)-2-(2,6-dichlorophenyl)imidazo[2,1-f][1,6]naphthyridine-3-carboxamide;
2-(2,6-Dichlorophenyl)-9-(1-(2-(methylsulfonyl)ethyl)-1H-pyrazol-4-yl)imidazo[2,1-f][1,6]naphthyridine-3-carboxamide;
9-(1-(1-Cyanoethyl)-1H-pyrazol-4-yl)-2-(2,6-dichlorophenyl)imidazo[2,1-f][1,6]naphthyridine-3-carboxamide;
2-(2,6-Dichlorophenyl)-9-(1-(2,2-difluoroethyl)-1H-pyrazol-4-yl)imidazo[2,1-f][1,6]naphthyridine-3-carboxamide;
2-(2,6-Dichlorophenyl)-9-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)imidazo[2,1-f][1,6]naphthyridine-3-carboxamide;
2-(2,6-Dichlorophenyl)-9-(1-(1-hydroxy-2-methylpropan-2-yl)-1H-pyrazol-4-yl)imidazo[2,1-f][1,6]naphthyridine-3-carboxamide;
9-(1-(2-Cyanopropan-2-yl)-1H-pyrazol-4-yl)-2-(2,6-dichlorophenyl)imidazo[2,1-f][1,6]naphthyridine-3-carboxamide;
9-(1-Cyclopropyl-1H-pyrazol-4-yl)-2-(2,6-dichlorophenyl)imidazo[2,1-f][1,6]naphthyridine-3-carboxamide;
2-(2,6-Dichlorophenyl)-9-(1-(2,2,2-trifluoroethyl)-1H-pyrazol-4-yl)imidazo[2,1-f][1,6]naphthyridine-3-carboxamide;
2-(2,6-Dichlorophenyl)-9-(1-(2-(dimethylamino)ethyl)-1H-pyrazol-4-yl)imidazo[2,1-f][1,6]naphthyridine-3-carboxamide;
2-(2,6-Dichlorophenyl)-9-(1-(1-methoxy-2-methylpropan-2-yl)-1H-pyrazol-4-yl)imidazo[2,1-f][1,6]naphthyridine-3-carboxamide;
2-(2,6-Dichlorophenyl)-9-(1-(2-hydroxypropyl)-1H-pyrazol-4-yl)imidazo[2,1-f][1,6]naphthyridine-3-carboxamide;
2-(2,6-Dichlorophenyl)-9-(1-(3-(dimethylamino)propyl)-1H-pyrazol-4-yl)imidazo[2,1-f][1,6]naphthyridine-3-carboxamide;
2-(2,6-Dichlorophenyl)-9-(1-methyl-1H-imidazol-4-yl)imidazo[2,1-f][1,6]naphthyridine-3-carboxamide;
2-(2,6-Dichlorophenyl)-9-(6-oxo-1,6-dihydropyridin-3-yl)imidazo[2,1-f][1,6]naphthyridine-3-carboxamide;
2-(2,6-Dichlorophenyl)-9-(5-isopropyl-1H-pyrazol-4-yl)imidazo[2,1-f][1,6]naphthyridine-3-carboxamide;
2-(2,6-Dichlorophenyl)-9-(5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)imidazo[2,1-f][1,6]naphthyridine-3-carboxamide;
2-(2,6-Dichlorophenyl)-9-(5-(2-hydroxypropan-2-yl)pyridin-3-yl)imidazo[2,1-f][1,6]naphthyridine-3-carboxamide;
2-(2,6-Dichlorophenyl)-9-(2-(methylamino)pyrimidin-5-yl)imidazo[2,1-f][1,6]naphthyridine-3-carboxamide;
2-(2,6-Dichlorophenyl)-9-(1-(tetrahydrofuran-3-yl)-1H-pyrazol-4-yl)imidazo[2,1-f][1,6]naphthyridine-3-carboxamide;
2-(2,6-Dichlorophenyl)-9-(1-(2-morpholinoethyl)-1H-pyrazol-4-yl)imidazo[2,1-f][1,6]naphthyridine-3-carboxamide;
2-(2,6-Dichlorophenyl)-9-(1-(2-(4-methylpiperazin-1-yl)ethyl)-1H-pyrazol-4-yl)imidazo[2,1-f][1,6]naphthyridine-3-carboxamide;
2-(2,6-Dichlorophenyl)-9-(1-(3-hydroxypropyl)-1H-pyrazol-4-yl)imidazo[2,1-f][1,6]naphthyridine-3-carboxamide;
9-(1-(2-Cyanoethyl)-1H-pyrazol-4-yl)-2-(2,6-dichlorophenyl)imidazo[2,1-f][1,6]naphthyridine-3-carboxamide;
9-(1-(2-Amino-2-oxoethyl)-1H-pyrazol-4-yl)-2-(2,6-dichlorophenyl)imidazo[2,1-f][1,6]naphthyridine-3-carboxamide;
2-(2,6-Dichlorophenyl)-9-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)imidazo[2,1-f][1,6]naphthyridine-3-carboxamide;
2-(2,6-Dichlorophenyl)-9-(6-(2,2,2-trifluoroethyl)pyridin-3-yl)imidazo[2,1-f][1,6]naphthyridine-3-carboxamide;
2-(2,6-Dichlorophenyl)-9-(6-(methylcarbamoyl)pyridin-3-yl)imidazo[2,1-f][1,6]naphthyridine-3-carboxamide;
2-(2,6-Dichlorophenyl)-9-(4-hydroxycyclohex-1-en-1-yl)imidazo[2,1-f][1,6]naphthyridine-3-carboxamide;
2-(2,6-Dichlorophenyl)-9-(5-hydroxypent-1-yn-1-yl)imidazo [2,1-f][1,6]naphthyridine-3-carboxamide;
2-(2,6-Dichlorophenyl)-9-(2-hydroxypropan-2-yl)imidazo[2,1-f][1,6]naphthyridine-3-carboxamide;
2-(2,6-Dichlorophenyl)imidazo[2,1-f][1,6]naphthyridine-3-carboxamide;
2-Methyl-9-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)imidazo[2,1-f][1,6]naphthyridine-3-carboxamide; and
9-(1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)imidazo [2,1-f][1,6]naphthyridine-3-carboxamide,
or a pharmaceutically acceptable salt of any of the aforementioned.