Patent ID: 11940508
Assignee: BEIJING UNIVERSITY OF AERONAUTICS AND ASTRONAUTICS
Field: Measurement (Instruments)
Classification: CPC G  A | IPC A  G

Claim 5:
6. An MPI and FMT-fused multimodal imaging method for a small animal, based on the MPI and FMT-fused multimodal imaging system for the small animal according to claim 1, and comprising:
S100: fixing the target object to the object table, and injecting a magnetic-nano and optical-fused probe into a body of the target object;
S200: applying currents to the gradient coil to generate the static FFL;
S300: applying a high-frequency excitation current to the driving coil, changing a current ratio between the gradient coil and the driving coil, and controlling translation and rotation of the FFL in the space, thereby scan-imaging the target object on the object table;
S400: decoding and reconstructing the nonlinear response signal acquired by the reception coil to generate an MPI cross-sectional image comprising particle concentration information at different depth positions;
S500: performing, by the fluorescence camera, grayscale subtraction between an acquired original fluorescence signal and a previously acquired background signal to generate a fluorescence image of a surface of the target object; and preprocessing the fluorescence image of the surface of the target object through enhancement and denoising to generate a preprocessed fluorescence image;
S600: extracting a position of magnetic particles in the MPI cross-sectional image and concentration information of the magnetic particles at the position; registering, based on a fixed registration reference point, the MPI cross-sectional image into a three-dimensional (3D) grid space of computed tomography (CT) as a prior region for FMT reconstruction; and performing, in the prior region for FMT reconstruction, FMT reconstruction on the preprocessed fluorescence image to acquire a 3D structural fluorescence distribution of a lesion region in the body of the target object; and
S700: assigning the concentration information of the magnetic particles at the position in the MPI cross-sectional image to a grid node of the 3D structural fluorescence distribution, thereby acquiring an image fusion result comprising the 3D fluorescence distribution, the concentration information of the magnetic particles, and a 3D structure.