Patent ID: 11872324
Assignee: THE UNIVERSITY COURT OF THE UNIVERSITY OF GLASGOW
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 15:
16. A kit for preparing an implantable construct according to claim 1 comprising:
(a) a biocompatible substrate having a first surface and a material surface comprising an alkyl acrylate polymer deposited on said first surface, wherein the biocompatible substrate is selected from a synthetic polymer, a ceramic, a metal, an alloy and composites thereof and further wherein the alkyl acrylate polymer is capable of supporting the formation of a physiological fibrillar network of FN adsorbed on its surface; and
(b) fibronectin (FN) and a growth factor (GF) capable of forming a biologically active matrix when applied to said material surface, wherein said growth factor is capable of binding FNIII12-14; and
(c) instructions for adsorbing the fibronectin (FN) and a growth factor (GF) onto the material surface to form a biologically active matrix wherein the FN forms a physiological fibrillar network of FN presenting colocalized growth factor binding domains and integrin binding domains, thus forming an implantable construct.