Patent ID: 11952411
Assignee: JANSSEN BIOTECH, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 11:
12. A method of making an engineered TL1A ligand comprising (i) a step for performing the function of introducing at least one amino acid alteration of the amino acid sequence of SEQ ID NO:94 selected from the group consisting of: K111A, L123K, M158Y, Q167A, S187L, E190F, and N207F; and (ii) a step for performing the function of producing a population of engineered TL1A ligand, wherein optionally the method further comprises the step of fusing the engineered TL1A ligand to a heterologous polypeptide, wherein optionally the heterologous polypeptide comprises a protein stabilizing region, and wherein optionally the protein stabilizing region comprises an Fc region, or a HSA region.