Patent ID: 11883369
Assignee: YALE UNIVERSITY
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 0:
1. A method of treating or ameliorating a disease or disorder in a subject in need thereof, the method comprising:
administering to the subject a composition comprising a therapeutically effective amount of a mitochondrial uncoupling agent and at least one pharmaceutically acceptable carrier,
wherein the composition comprises an extended release coating comprising:
i) at least one water soluble polymer;
ii) at least one water insoluble polymer; and,

wherein the disease or disorder is at least one selected from the group consisting of non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), hepatic steatosis, type 2 diabetes (T2D), acquired lipodystrophy, (inherited) lipodystrophy, partial lipodystrophy, hypertriglyceridemia, obesity, metabolic syndrome, Rett's syndrome, metabolic syndrome associated with aging, metabolic diseases associated with increased reactive oxygen species (ROS), Friedreich's ataxia, insulin resistance, hepatic fibrosis, liver cirrhosis, and hepatocellular carcinoma,
whereby the disease or disorder is treated or ameliorated in the subject.