Patent ID: 11952413
Assignee: 2SEVENTY BIO, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A fusion polypeptide comprising:
(a) a first polypeptide comprising, in the following order:
(i) a first extracellular multimerization domain;
(ii) a first transmembrane domain; and
(iii) an IL-18R1 immune receptor intracellular signaling domain;

(b) a polypeptide cleavage signal; and
(c) a second polypeptide comprising, in the following order:
(i) a second extracellular multimerization domain;
(ii) a second transmembrane domain; and
(iii) an IL-18RAP immune receptor intracellular signaling domain;

wherein the first extracellular multimerization domain comprises an FKBP12-rapamycin binding (FRB) polypeptide and the second extracellular multimerization domain comprises an FK506 binding protein (FKBP12) polypeptide; or
wherein the first extracellular multimerization domain comprises an FKBP12 polypeptide and the second extracellular multimerization domain comprises an FRB polypeptide; and
wherein the fusion polypeptide has a sequence having at least 95% identity to SEQ ID NO: 5.