Patent ID: 11952428
Assignee: NOVARTIS AG
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 14:
15. A chimeric antigen receptor (CAR) that binds to BCMA, comprising, from N-terminus to C-terminus:
(i) leader sequence of SEQ ID NO: 1;
(ii) a HC CDR1 of SEQ ID NO: 86;
(iii) a HC CDR2 of SEQ ID NO: 87;
(iv) a HC CDR3 of SEQ ID NO: 88;
(v) a LC CDR1 of SEQ ID NO: 95;
(vi) a LC CDR2 of SEQ ID NO: 96;
(vii) a LC CDR3 of SEQ ID NO: 97;
(viii) a CD8 transmembrane domain and hinge of SEQ ID NO: 202;
(ix) a functional signaling domain of 4-1BB of SEQ ID NO: 7; and
(x) a functional signaling domain of CD3 zeta of SEQ ID NO: 10.