Patent ID: 11905531
Assignee: BOEHRINGER INGELHEIM ANIMAL HEALTH USA INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 4:
5. A method of treating a mammalian subject suffering from osteoarthritis (OA), comprising intra-articularly administering to said mammalian subject a therapeutically effective amount of a recombinant adeno-associated virus (rAAV) comprising an rAAV vector, wherein the rAAV vector comprises a DNA genome comprising a nucleic acid encoding a canine hyaluronan synthase 2 (HAS2) polypeptide operably linked to a promoter, wherein the polypeptide is expressed in vivo in the mammalian subject in an amount effective to alleviate the symptoms of OA, wherein the rAAV comprises an AAV5 capsid, and wherein the nucleic acid encodes a HAS2 polypeptide comprising the amino acid sequence set forth in SEQ ID NO:2.