Patent ID: 11964949
Assignee: THE GLOBAL ALLIANCE FOR TB DRUG DEVELOPMENT, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A compound of Formula I, or a pharmaceutically acceptable salt, hydrate, or solvate of:, wherein:
R is independently OR1, OC(O)R2, OC(O)NHR2, OS(O2)R2, NHS(O)2R2, NR3R4, NHC(O)R5;
R′ and R″ are independently H, F, Cl or OMe;
each R1 is independently C1-C6 alkyl, C3-C8 cycloalkyl, wherein said alkyl, cycloalkyl are optionally substituted with 1 to 4 groups selected from halo, hydroxy, C1-C6 alkyl, C1-C6 alkyloxy;
each R2 is independently C3-C8 cycloalkyl, heterocyclyl, heteroaryl or aryl, wherein said cycloalkyl, heterocyclyl, heteroaryl, or aryl are optionally substituted with 1 to 4 groups selected from halo, hydroxyl, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 acyloxy, CF3, NO2, CN and NH2;
each R3 and R4 is independently H, C1-C6 alkyl, C3-C8 cycloalkyl, heterocyclyl heteroaryl, aryl, wherein R3 and R4 are not both H; or R3 and R4 taken together with the nitrogen to which they are attached, form a 4- to 8-membered heterocyclyl or heteroaryl with 1 to 3 additional heteroatoms selected from O, S, or N, wherein said alkyl, cycloalkyl, heterocyclyl, heteroaryl, or aryl are optionally substituted with 1 to 4 groups selected from halo, C1-C6 alkyl, C1-C6 alkoxy, CF3, NO2, CN;
each R5 is independently C3-C8 cycloalkyl, heteroaryl, aryl, wherein said cycloalkyl, heterocyclyl, heteroaryl, or aryl are optionally substituted with 1 to 4 groups selected from halo, hydroxyl, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 acyloxy, CF3, NO2, CN and NH2;
Ring A is selected from:, wherein,
each R6 and R7 is independently H, F, CH3, CH2CH3, CF3, phenyl;
X=O, S, SO, SO2;
m is 1, or 2;
R8 in independently H, C1-C4 alkyl, C3-C6 cycloalkyl, COCH3, and p-toluenesulfonyl, wherein
said alkyl, cycloalkyl are optionally substituted with 1 to 4 groups selected from halo, hydroxyl, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 acyloxy, CF3, NO2, CN and NH2,
and wherein R is not triazole.