Patent ID: 11945946
Assignee: ENCAPSYS, LLC
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C  B  F | IPC A  B  C

Claim 23:
24. A method of producing the PU/PBAE microcapsule of claim 1, comprising:
providing a first aqueous solution comprising an emulsifier and water;
providing a second aqueous solution comprising a multifunctional amine and water;
providing an oil phase comprising the core material and a polyisocyanate;
adding the oil phase into the first aqueous solution, applying high shear agitation at a first temperature until a target particle size is reached to obtain a first emulsion;
adding the second aqueous solution into the first emulsion under mixing to obtain a second emulsion;
providing a third aqueous solution comprising a multifunctional acrylate having an α,β-unsaturated carbonyl, and adding the third aqueous solution into the second emulsion under mixing, wherein the multifunctional amine reacts with the multifunctional acrylate having the α,β-unsaturated carbonyl to form PBAE, in which the multifunctional amine adds by aza-Michael addition to a β-carbon atom of the α,β-unsaturated carbonyl; and
increasing a temperature to a second temperature in a first period of time and hold the temperature at the second temperature for a second period of time under mixing.