Patent ID: 11896349
Assignee: CASE WESTERN RESERVE UNIVERSITY
Field: Medical technology (Instruments)
Classification: CPC A  G | IPC A  G

Claim 10:
11. A non-transitory computer-readable medium storing computer-executable instructions that, when executed, cause a processor to perform operations, comprising:
accessing a training set comprising a plurality of routine clinical medical imaging scans, wherein each routine clinical medical imaging scan of the training set is associated with a three-dimensional segmentation including a three-dimensionally segmented associated tumor and a three-dimensionally segmented set of tumor-associated vasculature (TAV) associated with the associated tumor, wherein the associated tumor of that routine clinical medical imaging scan is associated with at least one of a known response to a treatment or a known prognosis; and
for each routine clinical medical imaging scan of the training set, extracting associated values for a set of features from the associated TAV for the associated tumor of that routine clinical medical imaging scan, the set of features including one or more of at least one TAV spatial orientation feature or a statistic of the at least one TAV spatial orientation feature and at least one TAV morphology feature or a statistic of the at least one TAV morphology feature, said extracting using one or both of at least a portion of the three-dimensional segmentation or a projection onto a plane of at least a portion of the three-dimensional segmentation, such that the set of features represent spatial orientation and morphology of at least a portion of the associated TAV in three dimensions; and
training a machine learning model based on the associated values extracted from the associated TAV for the associated tumor of that routine clinical medical imaging scan and on the at least one of the known response to the treatment or the known prognosis.