Patent ID: 11859023
Assignee: NAVIDEA BIOPHARMACEUTICALS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 15:
16. A method for synthesizing an amine dextran comprising:
a. reacting a chelator with an aminated dextran backbone, wherein the chelator comprises a plurality of carboxylic acid groups, each conjugated to a protecting group with the exception of only one carboxylic acid derivatized as a single activated mono-N-hydroxysuccinimide (NHS) ester, to form a chelator-dextran complex;
b. removing the protecting groups from each of the plurality of carboxylic acid groups; and
c. adding a plurality of mannose moieties to the chelator dextran complex through amidate linkage to the dextran backbone.