Patent ID: 11945794
Assignee: KARYOPHARM THERAPEUTICS INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 9:
10. A compound of structural formula III:, or a pharmaceutically acceptable salt thereof, wherein:
Rb is selected from —
C(O)OH, —C(O)NH2, —C(O)—N(R7)—N(R5)(R6), —C(O)—N(R7)—N(R7)—C(O)—R4 and —C(O)—N(R7)—N(R7)—S(O)1-2—R4; wherein:
R4 is selected from —N(H)(C3-C6 cycloalkyl), —N(C1-C4 alkyl)(C3-C6 cycloalkyl), —C1-C6 alkyl, —(C0-C4 alkylene)-carbocyclyl, —(C0-C4 alkylene)-heterocyclyl, -(C0-C4 alkylene)-aryl, and —(C0-C4 alkylene)-heteroaryl;
R5 and R6 are each independently selected from hydrogen, C1-C4 alkyl, C2-C4 alkenyl, C2-C4 alkynyl, carbocyclyl, aryl, heterocyclyl and heteroaryl; or
R5 and R6 are taken together with the nitrogen atom to which they are commonly attached to form a heterocyclyl or heteroaryl; and
each R7 is independently hydrogen or C1-C4 alkyl; and

R2 is an optionally substituted C5-C15 heteroaryl, wherein:
unless otherwise designated, each alkyl, alkenyl, alkynyl, alkylene, carbocyclyl, aryl, cycloalkyl, heterocyclyl and heteroaryl is optionally and independently substituted.