Patent ID: 11858987
Assignee: CHUGAI SEIYAKU KABUSHIKI KAISHA
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A  G  Y | IPC A  C  G

Claim 0:
1. A method for detecting a cancer stem cell (CSC) in a sample, comprising:
contacting the sample with at least one antibody that binds an ectodysplasin A receptor (EDAR) protein of SEQ ID NO: 1, a CD70 protein of SEQ ID NO: 2, an epiregulin (EREG) protein of SEQ ID NO: 3, a protein C receptor, endothelial (PROCR) protein of SEQ ID NO: 5, a prominin 2 (PROM2) protein of SEQ ID NO: 6, a tumor necrosis factor (ligand) superfamily, member 9 (TNFSF9) protein of SEQ ID NO: 7, a poliovirus receptor-related 4 (PVRL4) protein of SEQ ID NO: 8, or a TNF receptor superfamily, member 6 (FAS) protein of SEQ ID NO: 9; and
detecting binding of the at least one antibody to the sample, thereby detecting the CSC,
wherein the sample is from a patient with cancer, and the cancer is an Lgr5-negative cancer.