Patent ID: 11939616
Assignee: THE BRIGHAM AND WOMEN'S HOSPITAL
Field: Biotechnology (Chemistry)
Classification: CPC C | IPC A  C

Claim 0:
1. A process for custom engineering a fucosylated lactosaminyl glycan comprising:
(a) determining a desired enforced glycosylation pattern for a target human cell, wherein the enforced glycosylation pattern is selected from the group consisting of:
(i) sLex (+)>>Lex(+), with Di-Fuc-sLex (+), and VIM-2 (−); and
(ii) Lex(+), sLex (−), VIM-2 (−), and Di-Fuc-sLex (−);

(b) selecting an α(1,3)-fucosyltransferase VI capable of producing the desired glycosylation pattern; and
(c) contacting the target human cell with the selected α(1,3)-fucosyltransferase VI.