Patent ID: 11873512
Assignee: NATIONAL UNIVERSITY OF SINGAPORE
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 9:
10. A method of producing a population of immune cells for use in treating cancer, said method comprising:
obtaining a peripheral blood sample comprising mononuclear cells;
culturing said mononuclear cells under culture conditions resulting in the expansion of natural killer (NK) and T cells; and
introducing into the NK cells and into the T cells a nucleic acid encoding a chimeric receptor comprising:
i) an extracellular receptor domain, wherein said extracellular receptor domain comprises a fragment of NKG2D that binds one or more of MICA, MICB, ULBP1, ULBP2, ULBP3, ULBP4, ULBP5, and ULBP6, and
ii) a CD3 zeta cytoplasmic domain.