Patent ID: 11938247
Assignee: CATHOLIC UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
Field: Medical technology (Instruments)
Classification: CPC A  B | IPC A

Claim 0:
1. A method for fabricating a human nasal turbinate-derived mesenchymal stem cell-based 3D bioprinted stem cell construct, the method comprising the steps of:
(a) isolating mesenchymal stem cells from a nasal turbinate tissue collected during the process of surgically removing the human nasal turbinate;
(b) fabricating a bio-ink by encapsulating the isolated mesenchymal stem cells in a hydrogel; and
(c) fabricating a 3D bioprinted stem cell construct by micro-extruding the bio-ink together with polycaprolactone (PCL) using a multihead dispenser,
wherein the human nasal turbinate-derived mesenchymal stem cell-based 3D bioprinted stem cell construct obtained has bone defect regeneration ability, and
wherein the human nasal turbinate-derived mesenchymal stem cell is differentiated into osteocytes.