Patent ID: 11883223
Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Field: Medical technology (Instruments)
Classification: CPC A  G | IPC A  G

Claim 10:
11. A system comprising an image reconstruction device comprising:
a processor; and
a non-transitory computer readable medium coupled to the processor, the non-transitory computer readable medium comprising code executable by the processor for determining a plurality of kinetic parameters associated with a kinetic model of an imaging agent in a liver, performed by an image reconstruction device, wherein the code, when executed by the processor, causes the processor to:
receive a plurality of imaging agent activities based on tracer transport kinetic imaging of the imaging agent in the liver during a predetermined time period;
generate a liver time activity curve and a circulatory input function based on the plurality of imaging agent activities;
jointly determine, based on the liver time activity curve and the circulatory input function, the plurality of kinetic parameters associated with the kinetic model of the imaging agent in the liver, wherein the plurality of kinetic parameters comprise at least two of a fractional blood volume, a blood to hepatic tissue rate, a hepatic tissue to blood rate, a phosphorylation rate, a dephosphorylation rate, a portal vein rate, and a hepatic artery fraction; and
generate an output characterizing liver inflammation in the liver at least based on the plurality of kinetic parameters.