Patent ID: 11903381
Assignee: TRANSMEDICS, INC.
Field: Biotechnology (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 39:
40. A system for perfusing an ex-vivo liver, the system comprising:
a pump configured to pump a perfusion fluid through a perfusion circuit, the pump in fluid communication with a hepatic artery interface and a portal vein interface;
a controller configured to cause the system to:
provide, via the pump and the hepatic artery interface, the perfusion fluid to a hepatic artery of the ex-vivo liver at a pressure between 25-150 mmHg and a flow rate between 0.25-1 L/min; and
provide, via the pump and the portal vein interface, the perfusion fluid to a portal vein of the ex-vivo liver at a flow rate between 0.75-2 L/min;

an oxygenator;
a clamp adapted to be positioned between the pump and the portal vein interface, the clamp configured to be usable to control the pressure of the perfusion fluid provided to the hepatic artery;
a solution pump configured to provide a maintenance solution to the perfusion fluid; and
an inferior vena cava interface in fluid communication with an inferior vena cava of the ex-vivo liver.