Patent ID: 11970474
Assignee: THOMAS HELLEDAYS STIFTELSE FÖR MEDICINSK FORSKNING
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A compound of formula I, or a pharmaceutically acceptable salt thereof, wherein:
X1 and X2 each independently represent O or S;
each of Y1, Y2, and Y3 is CH, and Y4 is CR3;
both Z1 and Z2 represent methylene;
Z3 represents CH, CR1 or N;
each R1 independently represents fluoro, methyl or hydroxyl;
n represents 0 or 1;
R2 represents
(i) phenyl optionally substituted by one or more groups independently selected from A4,
(ii) 5- or 6-membered monocyclic heteroaryl optionally substituted by one or more groups selected from oxy and A5, or
(iii) phenyl substituted with two adjacent groups which, together with the ring to which they are attached, form a bicyclic heteroaryl optionally substituted by one or more groups selected from oxy and A6;

R3 independently represents
(i) halo, —NO2, —CN, —R2a, —OR2b, —S(O)qR2c, —S(O)rN(R2d)(R2e), —N(R2f)SOsR2g, —N(R2h)(R2i), —C(O)OR2j, or —C(O)NR2kR2l,
(ii) phenyl optionally substituted by one or more groups independently selected from A7,
(iii) heteroaryl optionally substituted by one or more groups selected from A8, or
(iv) heterocyclyl optionally substituted by one or more groups independently selected from A9;

R2a independently represents
(i) C1-6 alkyl, C2-6 alkenyl or C2-6 alkynyl, wherein each such alkyl, alkenyl or alkynyl group is substituted by one or more groups independently selected from oxy and B1;
(ii) phenyl optionally substituted by one or more groups independently selected from oxy and B2,
(iii) heteroaryl optionally substituted by one or more groups selected from oxy and B3, or
(iv) heterocyclyl optionally substituted by one or more groups independently selected from oxy and B4;

each R2b to R2l independently represents H or
(i) C1-6 alkyl, C2-6 alkenyl or C2-6 alkynyl, wherein each such alkyl, alkenyl or alkynyl group is optionally substituted by one or more groups independently selected from oxy and B1;
(ii) phenyl optionally substituted by one or more groups independently selected from oxy and B2,
(iii) heteroaryl optionally substituted by one or more groups selected from oxy and B3, or
(iv) heterocyclyl optionally substituted by one or more groups independently selected from oxy and B4;

each A4 to A9 independently represents
(i) halo, NO2, —CN, —R3a, —OR3b, —S(O)qR3c, —S(O)rN(R3d)(R3e), —N(R3f)SOsR3g, —N(R3h)(R3i), —C(O)OR3j, or —C(O)NR3kR3l;

each B1 independently represents
(i) halo, NO2, —CN, —OR4b, —S(O)qR4c, —S(O)rN(R4d)(R4e), —N(R4f)SOsR4g, —N(R4h)(R4i), —C(O)OR4j, or —C(O)NR4kR4l,
(ii) phenyl optionally substituted by one or more groups independently selected from D4,
(iii) heteroaryl optionally substituted by one or more groups selected from D5, or
(iv) heterocyclyl optionally substituted by one or more groups independently selected from D6;

each B2 to B4 independently represents
(i) halo, NO2, —CN, —R4a, —OR4b, —S(O)qR4c, —S(O)rN(R4d)(R4e), —N(R4f)SOsR4g, —N(R4h)(R4i), —C(O)OR4j, or —C(O)NR4kR4l;

each R3a and R4a represents
(i) C1-6 alkyl, C2-6 alkenyl or C2-6 alkynyl, wherein each such alkyl, alkenyl or alkynyl group is optionally substituted by one or more groups independently selected from oxy and E1;

each R3b to R3l, and R4b to R4l independently represents H or
(i) C1-6 alkyl, C2-6 alkenyl or C2-6 alkynyl, wherein each such alkyl, alkenyl or alkynyl group is optionally substituted by one or more groups independently selected from oxy and E1;

each D4 to D6 independently represents
(i) halo, NO2, —CN, —R5a, —OR5b, —S(O)qR5c, —S(O)rN(R5d)(R5e), —N(R5f)SOsR5g, —N(R5h)(R5i), —C(O)OR5j, or —C(O)NR5kR5l;

each E1 independently represents
(i) halo, NO2, —CN, —OR6b, —S(O)qR6c, —S(O)rN(R6d)(R6e), —N(R6f)SOsR6g, —N(R6h)(R6i), —C(O)OR6j, or —C(O)NR6kR6l;

each R5a represents
(i) C1-6 alkyl, C2-6 alkenyl or C2-6 alkynyl, wherein each such alkyl, alkenyl or alkynyl group is optionally substituted by one or more groups independently selected from oxy and J1;

each R5b to R5l, and R6b to R6l independently represents H or
(i) C1-6 alkyl, C2-6 alkenyl or C2-6 alkynyl, wherein each such alkyl, alkenyl or alkynyl group is optionally substituted by one or more groups independently selected from oxy and J1;

each J1 independently represents
(i) halo, NO2, —CN, —OR8b, —S(O)qR8c, —S(O)rN(R8d)(R8e), —N(R8f)SOsR8g, —N(R8h)(R8i), —C(O)OR8j, or —C(O)NR8kR8l,
(ii) aryl optionally substituted by one or more groups independently selected from L1,
(iii) heteroaryl optionally substituted by one or more groups selected from L2, or
(iv) heterocyclyl optionally substituted by one or more groups independently selected from L3;

each R8b to R8l independently represents H or C1-3 alkyl optionally substituted with one or more fluoro;
each L1 to L3 independently represents halo, NO2, —CN, —R9a, —OR9b, —S(O)qR9c, —S(O)rN(R9d)(R9e), —N(R9f)SOsR9g, —N(R9h)(R9i), —C(O)OR9j, or —C(O)NR9kR9l,
each R9a independently represents C1-3 alkyl optionally substituted with one or more fluoro;
each R9b to R9l independently represents H or C1-3 alkyl optionally substituted with one or more fluoro; and
each q, r and s independently represents 0, 1 or 2.