Patent ID: 11946867
Assignee: MEMORIAL SLOAN KETTERING CANCER CENTER
Field: Measurement (Instruments)
Classification: CPC G | IPC G

Claim 24:
25. A method for 3D imaging by modulation interferometry, comprising,
directing, via one or more phase modulation devices, a first excitation beam to a first optical objective, wherein at least one of the one or more phase modulating devices is initially located at a first position;
directing, via a first set of reflective mirrors, a second excitation beam to a second optical objective;
collecting, at the first optical objective, a first portion of light provided by a sample;
collecting, at the second optical objective, a second portion of light provided by the sample;
combining the first portion of the provided light and the second portion of the provided light to form a first interference signal;
detecting, by one or more detectors, the first interference signal;
modulating an optical path length via the at least one of the one or more phase modulation devices from a first state to a second state to provide a second interference signal;
detecting, by the one or more detectors, the second interference signal;
modulating the optical path length via the one or more phase modulation devices to a third state to provide a third interference signal;
detecting, by the at least one of the one or more detectors, the third interference signal; and
processing, by a processor of a computing device, data corresponding to the first interference signal, the second interference signal, and the third interference signal to determine an axial position of one or more features of the sample.