Patent ID: 11878989
Assignee: SHANGHAI FOREFRONT PHARMA CO., LTD.
Field: Organic fine chemistry (Chemistry)
Classification: CPC C  Y | IPC C

Claim 10:
11. The method for preparing the L-erythro biopterin compound according to claim 10, wherein the compound represented by formula (IIa) and/or formula (IIb) undergoes a dihydroxylation reaction by the Sharpless asymmetric dihydroxylation reaction; wherein the steps of the Sharpless asymmetric dihydroxylation reaction are as follows:
Mix the compound represented by formula (IIa) and/or the compound represented by formula (IIb), oxidizing agent, dihydroxylation reagent, base, ligand, and solvent for reactions after the reaction is completed, quench the reaction, and separate;
among them, the dihydroxylation reagent is selected from one or more of the following reagents: OsO4, K2OsO4, OsO4 hydrate and K2OsO4 hydrate;
the oxidant is selected from one or more of the following reagents: K3[Fe(CN)6] or NMO;
the base is selected from one or more of potassium carbonate, sodium carbonate, cesium carbonate, potassium bicarbonate, sodium bicarbonate, NaOH, KOH, LiOH, NH4OH, t-BuONa, t-BuOK, t-BuOLi, cesium carbonate, triethylamine, diisopropylethylamine, DBU, pyridine and p-dimethylaminopyridine;
the ligand is selected from one or more of the following reagents: (DHQ)2PHAL, (DHQD)2PHAL, DHQ-IND and DHQD-IND.