Patent ID: 11970474
Assignee: THOMAS HELLEDAYS STIFTELSE FÖR MEDICINSK FORSKNING
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 12:
13. A process for the preparation of a compound as defined in claim 1, comprising the step of:
(i) for compounds of formula I wherein X1 represents O, reacting a compound of formula II, wherein R1, R2, X2, Y1 to Y4, Z1 to Z3, and n are as defined in claim 1, with phosgene or a suitable equivalent thereof, in the presence of a suitable solvent and a suitable base;
(ii) for compounds of formula I wherein Z3 represents N, reaction of a compound of formula III, wherein R1, X1, Y1 to Y4, Z1, Z2, and n are as defined in claim 1, with a compound of formula IV, or a suitable salt thereof, wherein X2 and R2 are as defined in claim 1, in the presence of a suitable solvent and a suitable base;
(iii) reaction of a compound of formula III as defined herein with a compound of formula V, wherein R2 is as defined in claim 1, and with phosgene or a suitable equivalent thereof, in the presence of a suitable solvent and a suitable base;
(iv) where Z3 represents CH or CR1, reaction of a compound of formula VI, wherein R1, X1, Y1 to Y4, Z1, Z2, and n are as defined in claim 1, with a compound of formula V, in presence of a suitable coupling agent and in the presence of a suitable solvent and a suitable base; or
(v) for compounds of formula I wherein R3 group represents an alkyl, aryl, heteroaryl or heterocycloalkyl group, reaction of a corresponding compound of formula I but wherein the R3 group instead represents LG1, wherein LG1 represents a suitable leaving group, with a compound of formula VII, wherein R3 is as defined in claim 1 and LG2 represents a suitable leaving group, in the presence of a suitable catalyst, and in the presence of a suitable solvent and a suitable base.