Patent ID: 11873292
Assignee: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
Field: Organic fine chemistry (Chemistry)
Classification: CPC C  A  Y | IPC A  C

Claim 0:
1. A compound of the following formula I, or a enantiomer, diastereomer, racemate or mixture thereof, or a pharmaceutically acceptable salt, crystalline hydrate, or solvate thereof:, wherein:
n=1 or 2;
X is none or —(CH2)1-4, —CH(Ra)(CH2)0-3, —C(Ra)2(CH2)0-3, C3-C6 cycloalkane, carbonyl, or carbonyl-oxo, wherein each Ra of X is independently C1-C4 alkyl;
Y is sulfonyl, carbonyl or carbonyl-oxo;
R1 is selected from —H, substituted or unsubstituted C1-C12 alkyl, substituted or unsubstituted C3-C12 cycloalkyl, substituted or unsubstituted 3-12 membered heterocyclic group (which comprises monocyclic, cyclo, spiro or bridged ring), substituted or unsubstituted C6-C10 aryl, substituted or unsubstituted 5-12 membered aromatic heterocyclic group, wherein R1 has 0, 1, 2, or 3 substituents selected from the group consisting of halogen, aryl, heteroaryl, C1-C6 alkyl, —SO2Ra, —NC(O)Ra, —CH2C(O)ORa, —C(O)ORa, —C(O)Ra, —C(O)NRaRb, substituted amino, amino, carbamido, amide, sulfonamide, aralkyl and heteroarylalkyl, wherein said heterocyclic group comprises 1-3 heteroatoms selected from the group consisting of N, O and S, wherein
each Ra of R1 is independently hydrogen, phenyl, phenylmethyl, 3,5-dimethylisoxazol-4-yl, 1,2-dimethyl-1H-imidazol-4-yl, C3-C7 cycloalkyl, C1-C6 alkyl, C1-C4 alkoxy, C1-C3 alkylamino or —NHPh,
Rb is hydrogen or C1-C3 alkyl, or when Ra and Rb are attached to the same atom, Ra and Rb together form 5- or 6-membered heterocycloalkyl ring;
R2 is selected from substituted or unsubstituted C1-C8 alkyl, substituted or unsubstituted C3-C12 cycloalkyl, substituted or unsubstituted C6-C10 aromatic ring or substituted or unsubstituted 3-12 membered aromatic heterocyclic ring containing 1-4 hetero atoms selected from oxygen, sulfur or nitrogen;
wherein the substituents is/are selected from the group consisting of deuterium, tritium, halogen, C1-C12 alkyl which is unsubstituted or substituted by 1-3 halogen, C1-C12 alkoxy which is unsubstituted or substituted by 1-3 halogens or phenyls, C2-C12 alkenyl which is unsubstituted or substituted by 1-3 halogens, C3-C6 cycloalkyl which is unsubstituted or substituted by 1-3 halogens, C1-C6 alkyl which is substituted by C1-C6 alkoxy, C1-C6 alkyl substituted by C3-C6 cycloalkyl, hydroxy, cyano, nitro, C1-C6 straight or branched hydroxyalkyl, amino group which is unsubstituted or substituted by 1 or 2 C1-C6 alkyls, carboxyl, hydrosulfuryl, or benzyl group which is unsubstituted or substituted by one or more substituents selected from the group consisting of carboxyl, C2-C6 ester group; or any two substituents on the substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted benzene ring or substituted aromatic heterocyclic ring may be bonded together with the adjacent carbon or hetero atom to form a 5-7 membered heterocyclic ring comprising 1 to 3 heteroatoms selected from the group consisting of N, O and S, and the 5-7 membered heterocyclic ring is optionally substituted with a substituent selected from the group consisting of hydrogen, hydrogen isotopes, halogen, trifluoromethyl, methoxy, C1-C6 straight or branched alkyl which is unsubstituted or substituted with 1-3 halogen, C1-C6 straight or branched alkoxy which is unsubstituted or substituted with 1-3 halogen, or hydroxy,
wherein the halogen is F, Cl, Br or I.