Patent ID: 11939365
Assignee: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A  G | IPC A  C  G

Claim 17:
18. The protein of claim 15, wherein the protein comprises:
(1) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 35 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 36;
(2) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 45 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 46;
(3) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 55 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 56;
(4) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 65 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 66;
(5) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 75 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 76;
(6) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 85 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 86;
(7) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 95 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 96;
(8) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 105 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 106;
(9) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 115 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 116;
(10) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 125 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 126;
(11) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 135 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 136;
(12) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 145 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 146;
(13) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 155 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 156;
(14) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 165 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 166;
(15) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 175 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 176;
(16) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 185 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 186;
(17) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 195 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 196;
(18) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 205 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 206;
(19) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 215 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 216;
(20) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 225 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 226;
(21) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 235 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 236;
(22) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 245 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 246;
(23) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 255 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 256;
(24) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 265 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 266;
(25) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 275 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 276;
(26) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 285 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 286;
(27) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 295 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 296;
(28) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 305 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 306;
(29) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 315 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 316;
(30) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 325 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 326;
(31) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 335 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 336;
(32) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 345 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 346;
(33) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 355 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 356;
(34) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 365 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 366;
(35) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 375 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 376;
(36) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 385 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 386;
(37) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 395 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 396;
(38) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 405 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 406;
(39) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 415 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 416;
(40) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 425 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 426;
(41) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 435 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 436;
(42) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 445 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 446;
(43) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 455 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 456;
(44) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 465 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 466;
(45) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 485 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 486;
(46) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 495 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 496;
(47) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 21-267 of SEQ ID NO: 35 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-304 of SEQ ID NO: 36;
(48) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-272 of SEQ ID NO: 45 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 20-305 of SEQ ID NO: 46;
(49) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 19-264 of SEQ ID NO: 55 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 24-307 of SEQ ID NO: 56;
(50) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 21-268 of SEQ ID NO: 65 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-305 of SEQ ID NO: 66;
(51) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 21-268 of SEQ ID NO: 75 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-307 of SEQ ID NO: 76;
(52) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-274 of SEQ ID NO: 85 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-306 of SEQ ID NO: 86;
(53) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-268 of SEQ ID NO: 95 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-307 of SEQ ID NO: 96;
(54) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 21-270 of SEQ ID NO: 105 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-302 of SEQ ID NO: 106;
(55) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 19-263 of SEQ ID NO: 115 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-307 of SEQ ID NO: 116;
(56) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 19-265 of SEQ ID NO: 125 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-307 of SEQ ID NO: 126;
(57) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 19-265 of SEQ ID NO: 135 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-307 of SEQ ID NO: 136;
(58) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 21-267 of SEQ ID NO: 145 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-304 of SEQ ID NO: 146;
(59) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 20-265 of SEQ ID NO: 155 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-305 of SEQ ID NO: 156;
(60) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 21-272 of SEQ ID NO: 165 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-305 of SEQ ID NO: 166;
(61) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 21-270 of SEQ ID NO: 175 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 27-304 of SEQ ID NO: 176;
(62) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 19-266 of SEQ ID NO: 185 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 27-305 of SEQ ID NO: 186;
(63) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-271 of SEQ ID NO: 195 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 20-304 of SEQ ID NO: 196;
(64) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 21-272 of SEQ ID NO: 205 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-307 of SEQ ID NO: 206;
(65) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-273 of SEQ ID NO: 215 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-307 of SEQ ID NO: 216;
(66) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-273 of SEQ ID NO: 225 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-307 of SEQ ID NO: 226;
(67) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-271 of SEQ ID NO: 235 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-313 of SEQ ID NO: 236;
(68) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-271 of SEQ ID NO: 245 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 17-303 of SEQ ID NO: 246;
(69) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 20-262 of SEQ ID NO: 255 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 27-307 of SEQ ID NO: 256;
(70) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 21-272 of SEQ ID NO: 265 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-311 of SEQ ID NO: 266;
(71) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-311 of SEQ ID NO: 275 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-314 of SEQ ID NO: 276;
(72) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 23-273 of SEQ ID NO: 285 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 17-304 of SEQ ID NO: 286;
(73) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-272 of SEQ ID NO: 295 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-307 of SEQ ID NO: 296;
(74) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-271 of SEQ ID NO: 305 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-306 of SEQ ID NO: 306;
(75) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 23-271 of SEQ ID NO: 315 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-307 of SEQ ID NO: 316;
(76) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-273 of SEQ ID NO: 325 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-308 of SEQ ID NO: 326;
(77) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 19-262 of SEQ ID NO: 335 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-306 of SEQ ID NO: 336;
(78) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-267 of SEQ ID NO: 345 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-305 of SEQ ID NO: 346;
(79) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-267 of SEQ ID NO: 355 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-307 of SEQ ID NO: 356;
(80) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-267 of SEQ ID NO: 365 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-307 of SEQ ID NO: 366;
(81) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 21-270 of SEQ ID NO: 375 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-298 of SEQ ID NO: 376;
(82) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 20-265 of SEQ ID NO: 385 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 25-305 of SEQ ID NO: 386;
(83) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-268 of SEQ ID NO: 395 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-307 of SEQ ID NO: 396;
(84) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 21-271 of SEQ ID NO: 405 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-307 of SEQ ID NO: 406;
(85) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 21-271 of SEQ ID NO: 415 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-307 of SEQ ID NO: 416;
(86) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 21-271 of SEQ ID NO: 425 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-307 of SEQ ID NO: 426;
(87) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 21-271 of SEQ ID NO: 435 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-307 of SEQ ID NO: 436;
(88) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 21-270 of SEQ ID NO: 445 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-303 of SEQ ID NO: 446;
(89) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 21-270 of SEQ ID NO: 455 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-303 of SEQ ID NO: 456;
(90) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 21-268 of SEQ ID NO: 465 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-313 of SEQ ID NO: 466;
(91) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 21-270 of SEQ ID NO: 485 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-306 of SEQ ID NO: 486; or
(92) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 23-271 of SEQ ID NO: 495 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-305 of SEQ ID NO: 496.