Patent ID: 11912754
Assignee: IMMUNOWAKE INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 9:
10. The antibody fusion protein of claim 8,
(i) wherein the immune checkpoint molecule is PD-1, and wherein the antibody comprises: heavy chain-CDR1 (HC-CDR1), HC-CDR2, and HC-CDR3 of a heavy chain comprising the amino acid sequence of SEQ ID NO: 12; and/or light chain-CDR1 (LC-CDR1), LC-CDR2, and LC-CDR3 of a light chain comprising the amino acid sequence of SEQ ID NO: 13;
(ii) wherein the immune checkpoint molecule is PD-1, and wherein the antibody comprises: HC-CDR1, HC-CDR2, and HC-CDR3 of a heavy chain comprising the amino acid sequence of SEQ ID NO: 15; and/or LC-CDR1, LC-CDR2, and LC-CDR3 of a light chain comprising the amino acid sequence of SEQ ID NO: 16;
(iii) wherein the immune checkpoint molecule is PD-L1, and wherein the antibody comprises: HC-CDR1, HC-CDR2, and HC-CDR3 of a heavy chain comprising the amino acid sequence of SEQ ID NO: 18; and/or LC-CDR1, LC-CDR2, and LC-CDR3 of a light chain comprising the amino acid sequence of SEQ ID NO: 19;
(iv) wherein the immune checkpoint molecule is PD-L1, and wherein the antibody comprises: HC-CDR1, HC-CDR2, and HC-CDR3 of a heavy chain comprising the amino acid sequence of SEQ ID NO: 21; and/or LC-CDR1, LC-CDR2, and LC-CDR3 of a light chain comprising the amino acid sequence of SEQ ID NO: 22; or
(v) wherein the immune checkpoint molecule is CTLA-4, and wherein the antibody comprises: HC-CDR1, HC-CDR2, and HC-CDR3 of a heavy chain comprising the amino acid sequence of SEQ ID NO: 9; and/or LC-CDR1, LC-CDR2, and LC-CDR3 of a light chain comprising the amino acid sequence of SEQ ID NO: 10.