Patent ID: 11957735
Assignee: QUIAPEG PHARMACEUTICALS AB
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A

Claim 0:
1. A compound of Formula (I):, or a pharmaceutically acceptable salt thereof, wherein:
the aliphatic moiety is a polyethylene glycol having an average molecular weight from about 500 Da to about 40,000 Da;
D is a residue of a GLP-1 polypeptide or an analog thereof;
Z1 is selected from O, S, and N(RN);
Z3 is selected from O and N(RN), or Z3 is absent;
A is O or N, wherein when A is O then R3 is absent;
RN is selected from H and optionally substituted C1-6 alkyl;
R3 is selected from H and C1-6 alkyl, or
R3 and R1, together with A and the carbon atom to which R1 is attached, form an optionally substituted 4 to 7 membered aliphatic heterocyclic ring; or
R3 and R2, together with A, the carbon atom to which R1 is attached, and the carbon atom to which R2 is attached, form an optionally substituted 4 to 8 membered aliphatic heterocyclic ring;
MA is a self-immolative group having any one of formulae (a)-(i):, wherein x denotes a point of attachment to Z1 and y denotes a point of attachment to Z3;
R1 and R2 are independently selected from the group consisting of hydrogen, optionally substituted C1-6 alkyl, optionally substituted C6-10 aryl and optionally substituted 5- to 14-membered heteroaryl;
or R1 and R2 are joined together with the carbon atoms to which they are attached to form an optionally substituted C3-7 cycloalkyl ring, an optionally substituted 4 to 7 membered aliphatic heterocyclic ring, an optionally substituted C6-10 aryl or an optionally substituted 5-to 14-membered heteroaryl;
or R1 and R2 are joined together to form a ribose ring system;
R7 and R8 are independently selected from H and C1-6 alkyl; and
E is a cleavable moiety.