Patent ID: 11952423
Assignee: DAIICHI SANKYO COMPANY, LIMITED
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC C

Claim 26:
27. A molecule which comprises;
(I) a first polypeptide comprising an antibody or a binding fragment thereof that binds specifically to human HLA/NY-ESO, wherein the antibody or the binding fragment thereof that binds specifically to human HLA/NY-ESO is an scFv, an scFv that binds specifically to CD3, and an Fc region (i) in that order from the N terminus toward the C terminus; and a second polypeptide comprising an Fc region (ii), wherein the first polypeptide is associated with the second polypeptide in the Fc region (i) and the Fc region (ii);
wherein the first polypeptide comprises an amino acid sequence consisting of amino acids 20 to 745 of the amino acid sequence as shown in SEQ ID NO: 96, an amino acid sequence consisting of amino acids 20 to 750 of SEQ ID NO: 156, or an amino acid sequence consisting of amino acids 20 to 750 of SEQ ID NO: 157;
wherein the second polypeptide comprises an amino acid sequence of amino acids 20 to 246 of SEQ ID NO: 84;
or
(II) a first polypeptide comprising the antibody or the binding fragment thereof that binds specifically to human HLA/NY-ESO, wherein the antibody or the binding fragment thereof that binds specifically to human HLA/NY-ESO is an scFv, an scFv that binds specifically to CD3, and an Fc region (i) in that order from the N terminus toward the C terminus; and a second polypeptide comprising an Fc region (ii), wherein the first polypeptide is associated with the second polypeptide in the Fc region (i) and the Fc region (ii);
wherein the first polypeptide comprises an amino acid sequence consisting of amino acids 20 to 745 of the amino acid sequence as shown in SEQ ID NO: 96, an amino acid sequence consisting of amino acids 20 to 750 of SEQ ID NO: 156, or an amino acid sequence consisting of amino acids 20 to 750 of SEQ ID NO: 157;
wherein the second polypeptide comprises an amino acid sequence of amino acids 20 to 246 of SEQ ID NO: 84;
wherein 1 or 2 amino acids are deleted from the carboxyl terminus of the amino acid sequence of at least one polypeptide comprised in the molecule.