Patent ID: 11884655
Assignee: TREVENA, INC.
Field: Organic fine chemistry (Chemistry)
Classification: CPC C | IPC C

Claim 2:
3. The process of claim 1, wherein the process comprises the steps of:
(a) adding EDC hydrochloride and ethyl cyanohydroxyiminoacetate to a solution of a compound of, , in dimethylformamide to form a mixture and stirring the mixture for at least about 1 hour;
(b) stifling the mixture of the step (a) with a compound of, (c) heating the mixture of the step (b) to a temperature at about 95° C. and stifling the mixture under the temperature for at least about 5 hour;
(d) cooling the mixture of the step (c) to about 15-20° C. and adding water to form a slurry;
(e) stifling the slurry of the step (d) at about 15-20° C. for about 1 h;
(f) filtering the slurry of the step (e) to form a solid;
(g) washing the solid of the step (f) with water and methyl-tert-butyl ether; and
(h) drying the solid of the step (g) at about 55° C. under vacuum to form the compound of, wherein the variables are as defined in claim 1.