Patent ID: 11878080
Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  B | IPC A  B

Claim 14:
15. A method of preparing the population of capsules of claim 1, the method comprising the steps of:
(i) contacting a flow of a first phase and a flow of a second phase in a channel, thereby generating in the channel a dispersion of discrete regions of the second phase in the first phase, wherein one of the first or second phase is an aqueous phase and the other phase is a water immiscible phase, and the one of the first and second phase comprises one or more proteins suitable for self-assembly, wherein the one or more proteins is provided in monomeric form and is soluble;
(ii) permitting the one or more proteins to self-assemble at the boundary layer of the discrete regions between the first and second phases under denaturing conditions; and
(iii) optionally collecting the outflow from the channel, thereby obtaining a droplet, which contains a capsule.