Patent ID: 11898005
Assignee: TISSIUM SA
Field: Medical technology (Instruments)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A composition comprising activated pre-polymers having a moiety derived from a polyol and a moiety derived from a polyacid as depicted in formula (I):, wherein:
each n individually represent an integer equal to or greater than 1 and each p represent an integer from 4-10;
R6 in each individual unit is independent and can be:
(i) a polymer chain;
(ii) —C(═O)—CR3═CR4R5, where R3, R4, R5 are, independently from one another, selected from H, alkyl, aryl, substituted alkyl, substituted aryl, carboxylic acid, ester, amide, amine, urethane, ether, and carbonyl; or
(iii) —H, alkyl, acyl, aryl, heterocycles, cycloalkyl, aromatic heterocycles, multicycloalkyl, ester, ether, halide, carboxylic acid, amino, alkylamino, dialkylamino, trialkylamino, amido, carbamoyl, thioether, thiol, alkoxy, or ureido groups;
provided that for at least one individual unit in said activated prepolymers, R6 is —C(═O)—CR3═CR4R5;

R7 is selected from the group consisting of alkyl, aryl, substituted alkyl, substituted aryl, amine, urethane, thiol, or thioester;
wherein at least one of said activated pre-polymers of said composition comprises a terminal carboxyl group that is protected by a group selected from alkyl, aryl, substituted alkyl, substituted aryl, amine, urethane, thiol, or thioester;
wherein when said composition comprises activated prepolymers with grafted anhydride, said composition has a molar ratio of grafted anhydride to the polyacid of less than 0.05 mol/mol; and
wherein the activated prepolymers are formed by activating prepolymers having a weight average molecular weight of from about 3000 to about 5000 Daltons and a polydispersity of less than 3.