Patent ID: 11970497
Assignee: NOVARTIS AG
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 17:
18. A compound selected from:
6′-fluoro-N-((5-methylfuran-2-yl)methyl)-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′-fluoro-1′-methyl-N-((5-methylfuran-2-yl)methyl)-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′,8′-difluoro-N-((2-methylfuran-3-yl)methyl)-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
N-((5-chlorofuran-2-yl)methyl)-6′-fluoro-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
N-((2,4-dimethylfuran-3-yl)methyl)-6′-fluoro-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
N-((1H-pyrazol-4-yl)methyl)-6′-fluoro-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
N-((4-carbamoylfuran-2-yl)methyl)-6′,8′-difluoro-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′,8′-difluoro-N-(furan-3-ylmethyl)-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
N-((1H-pyrazol-3-yl)methyl)-6′-fluoro-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′-fluoro-N-((2-methylfuran-3-yl)methyl)-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′,8′-difluoro-N-((3-hydroxypyridin-2-yl)methyl)-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
N-((6-(dimethylamino)pyridin-2-yl)methyl)-6′,8′-difluoro-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′-fluoro-N-((5-methyl-1H-pyrazol-3-yl)methyl)-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
N-((4-chloro-1-methyl-1H-pyrazol-5-yl)methyl)-6′-fluoro-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′-fluoro-4′-oxo-N-((2-(trifluoromethyl)furan-3-yl)methyl)-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
N-((3-ethyl-5-methylisoxazol-4-yl)methyl)-6′-fluoro-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′-fluoro-N-(isoxazol-4-ylmethyl)-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
N-((2,5-dimethylfuran-3-yl)methyl)-6′-fluoro-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′,8′-difluoro-N-((2-methoxypyridin-4-yl)methyl)-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′-fluoro-N-(isoxazol-3-ylmethyl)-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
N-((1H-indol-6-yl)methyl)-6′-fluoro-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′,8′-difluoro-N-((5-methylthiophen-2-yl)methyl)-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′-fluoro-N-(isoxazol-5-ylmethyl)-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′,8′-difluoro-N-((6-fluoropyridin-3-yl)methyl)-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′-fluoro-N-((5-methyl-2-(trifluoromethyl)furan-3-yl)methyl)-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′-fluoro-N-((3-methyl-1,2,4-oxadiazol-5-yl)methyl)-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
N-((6-aminopyridin-3-yl)methyl)-6′-fluoro-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′-fluoro-N-(oxazol-4-ylmethyl)-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
N-(benzo[c][1,2,5]oxadiazol-4-ylmethyl)-6′-fluoro-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide; and
6′-fluoro-N-((1-methyl-1H-pyrazol-4-yl)methyl)-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
or a pharmaceutically acceptable salt thereof.