Patent ID: 11965015
Assignee: MEDIKINE, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. An IL-7Rαγc ligand, wherein the IL-7Rαγc ligand comprises an amino acid sequence of Formula (6) (SEQ ID NO: 2125), an amino acid sequence of Formula (6a) (SEQ ID NO: 2126), an amino acid sequence of Formula (6b) (SEQ ID NO: 2127), an amino acid sequence of Formula (6c) (SEQ ID NO: 2128), an amino acid sequence of Formula (6d) (SEQ ID NO: 2129), an amino acid sequence of Formula (6e) (SEQ ID NO: 2130), an amino acid sequence of Formula (6f) (SEQ ID NO: 2131), or an amino acid sequence of Formula (6g) (SEQ ID NO: 2132):, (6)

-X198-X199-X200-I-P-W-C-T-L-D-P-G-X210-L-Q-C-A-W-

 

L-X217-X218-X219-X400-VVCQDWEGVELCWQ-

 

(6a)

-X199-X200-I-P-W-C-T-L-D-P-G-X210-L-Q-C-A-W-L-X217-

 

X218-X219-X400-VVCQDWEGVELCWQ-

 

(6b)

-X200-I-P-W-C-T-L-D-P-G-X210-L-Q-C-A-W-L-X217-

 

X218-X219-X400-VVCQDWEGVELCWQ-

 

(6c)

-I-P-W-C-T-L-D-P-G-X210-L-Q-C-A-W-L-X217-X218-

 

X219-X400-VVCQDWEGVELCWQ-

 

(6d)

-X198-X199-X200-I-P-W-C-T-L-D-P-G-X210-L-Q-C-A-W-

 

L-X217-X218-X400-VVCQDWEGVELCWQ-

 

(6e)

-X198-X199-X200-I-P-W-C-T-L-D-P-G-X210-L-Q-C-A-W-

 

L-X217-X400-VVCQDWEGVELCWQ-

 

(6f)

-X198-X199-X200-I-P-W-C-T-L-D-P-G-X210-L-Q-C-

 

A-W-L-X400-VVCQDWEGVELCWQ-

 

(6g)

-X198-X199-X200-I-P-W-C-T-L-D-P-G-X210-L-Q-C-

 

A-W-L-X400-VVCQDWEGVELCWQ-

wherein,
X198 is selected from A, G, P, S, T, and V;
X199 is selected from F, H, W, and Y;
X200 is selected from A, G, H, K, P, R, S, and T;
X210 is selected form A, G, P, S, and T;
X217 is selected from A, G, H, K, P, R, S, and T;
X218 is selected from an amino acid and a single bond;
X219 is selected from an amino acid and a single bond; and
X400 is selected from (G)n (SEQ ID NO: 9390), (GS)n (SEQ ID NO: 9391), (GGS)n (SEQ ID NO: 9392), (GGGS)n (SEQ ID NO: 9393), (GGGGS)n (SEQ ID NO: 9394), and a combination of any of the foregoing, wherein n is an integer from 1 to 5.