Patent ID: 11896674
Assignee: SUZHOU RIBO LIFE SCIENCE CO., LTD.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 17:
18. The siRNA conjugate according to claim 1, wherein the siRNA is any one of the following siRNAs:
siHB1M1S
Sense strand: GmsAmsAmAmGmUmAfUfGfUmCmAmAmCmGmAmAmUmUm (SEQ ID NO: 23)
Antisense strand: AmsAfsUmUmCmGfUmUmGmAmCmAmUmAfCmUfUmUmCmsUmsUm (SEQ ID NO: 25)
siHB2M1S
Sense strand: GmsAmsAmAmGmUmAfUfGfUmCmAmAmCmGmAmAmUmUm (SEQ ID NO: 23)
Antisense strand: AmsAfsUmUmCmGfUmUmGmAmCmAmUmAfCmUfUmUmCmsCmsAm (SEQ ID NO: 26)
siHB3M1S
Sense strand: GmsAmsAmAmGmUmAfUfGfUmCmAmAmCmGmAmAmUmAm (SEQ ID NO: 24)
Antisense strand: UmsAfsUmUmCmGfUmUmGmAmCmAmUmAfCmUfUmUmCmsUmsUm (SEQ ID NO: 27)
siHB4M1S
Sense strand: GmsAmsAmAmGmUmAfUfGfUmCmAmAmCmGmAmAmUmAm (SEQ ID NO: 24)
Antisense strand: UmsAfsUmUmCmGfUmUmGmAmCmAmUmAfCmUfUmUmCmsCmsAm (SEQ ID NO: 28)
siHB1M2 S
Sense strand: GmsAmsAmAmGfUmAfUfGfUmCmAmAmCmGmAmAmUmUm (SEQ ID NO: 29)
Anti sense strand: AmsAfsUmUmCmGfUmUfGfAmCmAmUmAfCmUfUmUmCmsUmsUm (SEQ ID NO:31)
siHB2M2S
Sense strand: GmsAmsAmAmGfUmAfUfGfUmCmAmAmCmGmAmAmUmUm (SEQ ID NO: 29)
Anti sense strand: AmsAfsUmUmCmGfUmUfGfAmCmAmUmAfCmUfUmUmCmsCmsAm (SEQ ID NO: 32)
siHB3M2S
Sense strand: GmsAmsAmAmGfUmAfUfGfUmCmAmAmCmGmAmAmUmAm (SEQ ID NO:30)
Anti sense strand: UmsAfsUmUmCmGfUmUfGfAmCmAmUmAfCmUfUmUmCmsUmsUm (SEQ ID NO:33)
siHB4M2S
Sense strand: GmsAmsAmAmGfUmAfUfGfUmCmAmAmCmGmAmAmUmAm (SEQ ID NO:30)
Anti sense strand: UmsAfsUmUmCmGfUmUfGfAmCmAmUmAfCmUfUmUmCmsCmsAm (SEQ ID NO:34)
siHB1M3S
Sense strand: GmsAmsAmAmGfUmAfUfGfUmCmAmAmCmGmAmAmUmUm (SEQ ID NO:29)
Anti sense strand: AmsAfsUmUmCmGfUmUmGmAmCmAmUmAfCmUfUmUmCmsUmsUm (SEQ ID NO:25)
siHB2M3S
Sense strand: GmsAmsAmAmGfUmAfUfGfUmCmAmAmCmGmAmAmUmUm (SEQ ID NO:29)
Anti sense strand: AmsAfsUmUmCmGfUmUmGmAmCmAmUmAfCmUfUmUmCmsCmsAm (SEQ ID NO:26)
siHB3M3S
Sense strand: GmsAmsAmAmGfUmAfUfGfUmCmAmAmCmGmAmAmUmAm (SEQ ID NO:30)
Anti sense strand: UmsAfsUmUmCmGfUmUmGmAmCmAmUmAfCmUfUmUmCmsUmsUm (SEQ ID NO:27)
siHB4M3S
Sense strand: GmsAmsAmAmGfUmAfUfGfUmCmAmAmCmGmAmAmUmAm (SEQ ID NO:30)
Anti sense strand: UmsAfsUmUmCmGfUmUmGmAmCmAmUmAfCmUfUmUmCmsCmsAm (SEQ ID NO:28)
siHB5M1S
Sense strand: UmsGmsGmAmAmAmGmUmAfUfGfUmCmAmAmCmGmAmAmUmAm (SEQ ID NO:56)
Anti sense strand: UmsAfsUmUmCmGfUmUmGmAmCmAmUmAfCmUfUmUmCmCmAmUmsUm (SEQ ID NO:57)
siHB6M2S
Sense strand: UmsGmsGmAmAmAmGfUmAfUfGfUmCmAmAmCmGmAmAmUmAm (SEQ ID NO:56)
Anti sense strand: UmsAfsUmUmCmGfUmUfGfAmCmAmUmAfCmUfUmUmCmCmAmsAmsUm (SEQ ID NO:58)
siHB7M3S
Sense strand: UmsGmsGmAmAmAmGfUmAfUfGfUmCmAmAmCmGmAmAmUmUm (SEQ ID NO:59)
Antisense strand: AmsAfsUmUmCmGfUmUmGmAmCmAmUmAfCmUfUmUmCmCmAmsUmsUm (SEQ ID NO:60).