Patent ID: 11931400
Assignee: PSOMAGEN, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C  G  Y | IPC A  C  G

Claim 9:
10. A therapeutic composition for improving a Toll-like receptor (TLR)-related condition, the therapeutic composition comprising a peptide configured to modulate TLR-related functionality and derived based on reengineering of a target peptide sequence associated with a microorganism-related modulator associated of a TLR, wherein the peptide corresponds to a peptide sequence comprising a combination of at least three motifs from a set of peptide sequence motifs, wherein the peptide corresponds to the peptide sequence comprising nXX[MOTIF1]nX[MOTIF2]nX[MOTIF3]XXn (SEQ ID NOS:35984-37711),
wherein X comprises any amino acid type or no amino acid,
wherein n comprises any number and type of amino acid, and
wherein the set of peptide sequence motifs comprising:
a first motif comprising XXGFXLKXX (SEQ ID NO: 1), wherein X in the first motif comprises any amino acid type or no amino acid;
a second motif comprising XXTPA[Z][B]XXX (SEQ ID NOS:2-5), wherein X in the second motif comprises any amino acid type or no amino acid, wherein Z in the second motif comprises at least one of (N,D), and wherein B in the second motif comprises at least one of (N,E);
a third motif comprising [X][Z][B]APW (SEQ ID NOS:6-245), wherein X in the third motif comprises at least one of (I,F,W,Y,A), wherein Z in the third motif comprises at least one of (D,A,Q,E,G,H,I,L,F,P,T,Y), and wherein B in the third motif comprises at least one of (Q,L,W,Y);
a fourth motif comprising PP[X][Z][B][O]P (SEQ ID NOS:246-693), wherein X in the fourth motif comprises at least one of (Y,P), wherein Z in the fourth motif comprises at least one of (W,Y,F,A,V,C,T,L,S,H,Q,E,G,I), wherein B in the fourth motif comprises at least one of (W,I,F,P,D,G,C,A), and wherein O in the fourth motif comprises at least one of (G,N);
a fifth motif comprising [X][Z][i][O][B][J][f] (SEQ ID NOS: 694-35253), wherein X in the fifth motif comprises at least one of (G,Y,W), wherein Z in the fifth motif comprises at least one of (W,V,I,F,R,M,S,L), wherein i in the fifth motif comprises at least one of (I,G), wherein O in the fifth motif comprises at least one of (Y,P,H,L,F), wherein B in the fifth motif comprises at least one of (I,D,Y,F,V,T,G,A,Q), wherein J in the fifth motif comprises at least one of (F,R,C,L,A,Q,D,V), and wherein fin the fifth motif comprises at least one of (F,Y);
a sixth motif comprising F[X]PPAP[J] (SEQ ID NOS:35254-35269), wherein X in the sixth motif comprises at least one of (P,S), and wherein J in the sixth motif comprises at least one of (P,Y,L,A,E,G,V,I);
a seventh motif comprising DFT[X]FPP (SEQ ID NOS:35270-35271), wherein X in the seventh motif comprises at least one of (V,I);
an eighth motif comprising [X]TPA[J]F[B] (SEQ ID NOS:35272-35283), wherein X in the eight motif comprises at least one of (Y,T,H), wherein J in the eight motif comprises at least one of (H,I), and wherein B in the eight motif comprises at least one of (Y,A);
a ninth motif comprising [B]AR[X]TP[Z]SPP (SEQ ID NOS:35284-35303), wherein B in the ninth motif comprises at least one of (P,A), wherein X in the ninth motif comprises at least one of (A,P,W,N,L), and wherein Z in the ninth motif comprises at least one of (P,F);
a tenth motif comprising [X][J]TAYKP[B] (SEQ ID NOS:35304-35323), wherein X in the tenth motif comprises at least one of (W,L), wherein J in the tenth motif comprises at least one of (A,N,S,W,E), and wherein B in the tenth motif comprises at least one of (S,F);
an eleventh motif comprising [X]A[J][B]AP[Z]I[O][U] (SEQ ID NOS:35324-35803), wherein X in the eleventh motif comprises at least one of (N,W,A), wherein J in the eleventh motif comprises at least one of (F,N,Y,P), wherein B in the eleventh motif comprises at least one of (P,H,Y,W,A), wherein Z in the eleventh motif comprises at least one of (Y,A), wherein O in the eleventh motif comprises at least one of (W,Q), and wherein U in the eleventh motif comprises at least one of (R, Q); and
a twelfth motif comprising H[X][J]QP[B]AQEP (SEQ ID NOS:35804-35839), wherein X in the twelfth motif comprises at least one of (E,G,W,F), wherein J in the twelfth motif comprises at least one of (G,A,N), and wherein B in the twelfth motif comprises at least one of (H,W,K).