Patent ID: 11931161
Assignee: ABBOTT LABORATORIES
Field: Measurement (Instruments)
Classification: CPC A  G  C | IPC A  C  G

Claim 9:
10. A method comprising:
a) performing at least one assay for cardiac troponin I (cTnI) and an early biomarker in at least one sample that is whole blood, serum, plasma, or cerebrospinal fluid obtained from a subject within about 24 hours after an actual or suspected injury to the head, wherein the early biomarker comprises ubiquitin carboxy-terminal hydrolase L1 (UCH-L1), glial fibrillary acidic protein (GFAP), or a combination thereof;
b) performing a head computed tomography (CT) scan on the subject when the level of cTnI in the sample is higher than a reference level of cTnI and the level of the early biomarker in the sample is higher than a reference level of the early biomarker; and
c) treating the subject for a moderate, severe or moderate to severe TBI, wherein the subject is treated (i) with one or more therapeutic agents selected from the group consisting of a diuretic, an anti-convulsant medication and a medication to sedate an individual or induce a coma, or any combination thereof; (ii) with one or more surgical procedures selected from the group consisting of removal of a hematoma, repairing a skull fracture, and a decompressive craniectomy, or any combinations thereof; (iii) with one or more therapies selected from the group consisting of physical therapy for TBI and occupational therapy for TBI, and any combinations thereof; or (iv) with any combination of (i)-(iii).