Patent ID: 11890294
Assignee: HYPHENS PHARMA PTE. LTD.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 0:
1. A method of treating or reducing likelihood of a condition caused by a defective skin barrier or for promoting skin barrier repair, wherein the condition is selected from the group consisting of eczema, atopic eczema, dermatitis, atopic dermatitis, non-atopic eczema, non-atopic dermatitis, seborrheic eczema, irritant contact dermatitis, allergic contact dermatitis, asteatotic eczema, pruritis, acne, dry skin and sensitive skin, the method comprising topical application of a composition to an external body surface of a subject who is affected by, or is at risk of being affected by, said condition or who is in need of skin barrier repair;
wherein the composition comprises:
a polyhdroxy acid and a zinc salt of its conjugate base, wherein the polyhydroxy acid is selected from the group consisting of lactobionic acid, gluconolactone, a combination of lactobionic acid and gluconolactone, and derivatives thereof;
a partition coefficient enhancer selected from the group consisting of propylene glycol, butylene glycol, pentylene glycol, hexylene glycol, 1,5 pentane diol, and combinations thereof, wherein the partition coefficient enhancer is at 15-30% w/w of the composition; and
a diffusion coefficient enhancer which is selected from a C12 to C14 straight chain fatty acid or a C14 straight chain primary alcohol, wherein the diffusion coefficient enhancer is at 1.0-2.0% w/w of the composition; and

wherein the composition has a pH in the range consisting of 2.7 to 5.0.