Patent ID: 11883496
Assignee: ADOCIA
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 1:
2. The composition according to claim 1,
wherein in formula XXXa′ of the co-polyamino acid bearing carboxylate charges and hydrophobic radicals:
D represents, independently, either a —CH2— group (aspartic unit) or a —CH2—CH2— group (glutamic unit),
R1 is a radical chosen from the group consisting of an H, a linear acyl group comprising from 2 to 10 carbon atoms, a branched acyl group comprising from 4 to 10 carbon atoms, a benzyl, a terminal amino acid unit and a pyroglutamate,
R2 is a hydrophobic radical -Hy or a —NR′R″ radical, R′ and R″, either identical or different, being chosen from the group consisting of H, the linear or branched or cyclic alkyls comprising from 2 to 10 carbon atoms and benzyl, and said R′ and R″ alkyls may form together one or more saturated, unsaturated and/or aromatic cycle(s), and/or may comprise heteroatoms, chosen from the group consisting of O, N and S,
X represents a cationic entity chosen from the group consisting of Na+ and K+, and
n+m represents the degree of polymerization DP of the co-polyamino acid, namely, the average number of monomeric units per co-polyamino acid chain and 5≤n+m≤250; and

wherein in formula X of the hydrophobic radicals -Hy:
r=1 and GpR is a radical according to formula VII:, GpG and GpH are each a radical according to formula XI:, GpC is a radical according to formula IX:, the * indicates the attachment sites of the different groups bonded by an amide function;
a is 0;
a′ is an integer equal to 1;
b is an integer equal to 0 or to 1;
c is an integer equal to 0 or to 1, and if c is equal to 0, then d is equal to 1 or to 2; and
d is an integer equal to 0, to 1, or to 2;
e is an integer equal to 0 or to 1;
g is an integer equal to 0, to 1, to 2, to 3, to 4, to 5 or to 6;
h is an integer equal to 0, to 1, to 2, to 3, to 4, to 5 or to 6;
l is 0 and l′ is 1; and
if e is different from 0, then at least one of g or h is different from 0; and
B is a linear or branched alkyl radical comprising 1 to 9 carbon atoms, optionally comprising an aromatic nucleus, or an unsubstituted ether or polyether radical comprising from 4 to 14 carbon atoms and from 1 to 5 oxygen atoms;
Cx is a linear or branched monovalent alkyl radical, optionally comprising a cyclic part, in which x indicates the number of carbon atoms and wherein 9≤x≤25;
G is a linear or branched alkyl radical of 1 to 8 carbon atoms, with said alkyl radical bearing one or more free carboxylic acid functions;
R is a radical chosen from the group consisting of a divalent alkyl radical, linear or branched, comprising 1 to 12 carbon atoms, a divalent alkyl radical, linear or branched, comprising 1 to 12 carbon atoms bearing at least one —CONH2 functions, and a unsubstituted ether or polyether radical comprising from 4 to 14 carbon atoms and 1 to 5 oxygen atoms;
the hydrophobic radical(s) -Hy according to formula X being bonded to the co-polyamino acid:
via a covalent bond between a nitrogen atom of the hydrophobic radical -Hy and a carbonyl borne by the co-polyamino acid, thus forming an amide function derived from the reaction of an amine function of the precursor -Hy′ of the hydrophobic -Hy radical and an acid function borne by the co-polyamino acid.