Patent ID: 11944680
Assignee: MYELOID THERAPEUTICS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A

Claim 6:
7. A composition comprising a recombinant polynucleic acid encapsulated by a nanoparticle delivery vehicle, wherein the recombinant polynucleic acid comprises a sequence encoding a chimeric fusion protein (CFP), the CFP comprising:
(a) an extracellular domain comprising an anti-TROP2 binding domain, and
(b) a transmembrane domain operatively linked to the extracellular domain;
wherein the CFP is expressed on the surface of myeloid cells that express endogenous FcR-gamma receptors, wherein the extracellular domain further comprises an extracellular domain from CD16a, CD64, CD68 or CD89 or fragment thereof, and wherein the extracellular domain from CD89 comprises an amino acid sequence of IHQDYTTQN (SEQ ID NO: 82).