Patent ID: 11951157
Assignee: UNIVERSITAT ZURICH
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 0:
1. A method of treating a patient suffering from a malignant tumor, wherein the malignant tumor is melanoma, the method comprising
a. administering into the malignant tumor, the vicinity of the malignant tumor, or the lymph node associated with the malignant tumor, an effective amount of
a recombinant IL-12 polypeptide comprising
i. a human IL-12 p35 comprising the amino acid sequence SEQ ID NO:5,
ii. a human IL-12 p40 comprising the amino acid sequence SEQ ID NO:6 and
iii. optionally, a human immunoglobulin G crystallisable fragment; and

b. systemically administering an effective amount of a non-agonist blockade of T-cell inhibitory antibody, wherein the antibody is an anti-PD-1 antibody, thereby treating the malignant tumor.