Patent ID: 11951240
Assignee: GAMBRO LUNDIA AB
Field: Medical technology (Instruments)
Classification: CPC A | IPC A

Claim 2:
3. A continuous renal replacement therapy (CRRT) apparatus comprising:
a filtration unit having a primary chamber and a secondary chamber separated by a semi-permeable membrane;
a blood circuit having a blood withdrawal line connected to an inlet of the primary chamber, and a blood return line connected to an outlet of the primary chamber, said blood circuit being configured for connection to a patient cardiovascular system;
a blood pump to circulate blood in the blood circuit;
a dialysis supply line connected to an inlet the secondary chamber;
a dialysate line connected to an outlet of the secondary chamber;
one or more lines to transfer a respective solution into blood;
at least one fluid source of a solution for each of said one or more lines, wherein said solution comprises at least one buffer agent in the form of bicarbonate or bicarbonate precursor;
a control unit configured to deliver a CRRT blood treatment to the patient using the CRRT apparatus, wherein, to deliver the CRRT blood treatment, the control unit is configured to:
receive a patient prescription including one or more of a blood flow rate in the blood circuit, a dialysis flow rate of dialysis fluid in the dialysis supply line, a patient fluid removal rate to be removed from the patient for setting a CRRT blood treatment,
calculate a steady state bicarbonate concentration in the blood of the patient who has to undergo the CRRT blood treatment, wherein said steady state bicarbonate concentration is calculated as a function of the concentration of said at least one buffer agent in said fluid source and as a function of one of the estimated or calculated net buffer load indicative of a steady state acid-base balance in the blood of the patient,
calculate the steady state bicarbonate concentration in the blood of the patient, and bicarbonate losses in the dialysate, further based on:
an estimation of an amount per unit of time of bicarbonate generated from metabolism of the bicarbonate precursor infused to the patient;
a bicarbonate infusion from the CRRT blood treatment to be delivered in terms of an amount per unit of time;
a predefined net buffer load chosen between 0 and 0.35 mmol/[h(kg)];
an acid infusion from citric acid contained in the fluid source in terms of an amount per unit of time;

compare the steady state bicarbonate concentration in the blood of the patient with a threshold, and
generate an alert when the steady state bicarbonate concentration in the blood of the patient exceeds the threshold.