Patent ID: 11884712
Assignee: HCW BIOLOGICS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A  Y | IPC C

Claim 0:
1. A multi-chain chimeric polypeptide comprising:
(a) a first chimeric polypeptide comprising:
(i) a first target-binding domain;
(ii) a soluble tissue factor domain comprising a sequence that is at least 80% identical to SEQ ID NO: 1; and
(iii) a first domain of a pair of affinity domains comprising a sequence that is at least 80% identical to SEQ ID NO: 14; and

(b) a second chimeric polypeptide comprising:
(i) a second domain of a pair of affinity domains comprising a sequence that is at least 80% identical to SEQ ID NO: 28; and
(ii) a second target-binding domain,

wherein the first chimeric polypeptide and the second chimeric polypeptide associate through the binding of the first domain and the second domain of the pair of affinity domains; and
wherein (A) the first target-binding domain comprises a sequence that is at least 80% identical to SEQ ID NO: 11 and the second target-binding domain comprises a sequence that is at least 80% identical to SEQ ID NO: 78, or (B) the first target-binding domain comprises a sequence that is at least 80% identical to SEQ ID NO: 78 and the second target-binding domain comprises a sequence that is at least 80% identical to SEQ ID NO: 11.