Patent ID: 11867627
Assignee: UNIVERSITY OF CONNECTICUT
Field: Measurement (Instruments)
Classification: CPC G  A | IPC A  G

Claim 7:
8. A compact diffuse optical tomography (DOT) system for generating a functional image of a lesion region of a subject, comprising:
a source subsystem including:
a plurality of laser diodes configured to generate near-infrared (NIR) optical waves; and
a laser diode driver board configured to drive the plurality of laser diodes;

a probe configured to emit the optical waves generated by the source subsystem toward the lesion region and configured to detect optical waves reflected by the lesion region;
a detection subsystem including:
a miniaturized detection board including a photomultiplier tube (PMT) having a plurality of channels and configured to convert the optical waves detected by the probe to electrical signals; and
a miniaturized data acquisition board configured to convert electrical signals outputted by the miniaturized detection board to digital signals, and to output the digital signals from the detection subsystem; and
a computing device separate from the source subsystem, the probe, and the detection subsystem, the computing device configured to:
receive the digital signals sent from the detection subsystem, the digital signals comprising lesion functional data from the lesion region of the subject and reference functional data from a healthy tissue region of the subject;
reconstruct the functional image of the lesion region based on the digital signals by:
transforming the lesion functional data and the reference functional data to produce perturbation data;
generating a preliminary estimate of the functional image by applying a truncated pseudoinverse matrix of a weight matrix to the perturbation data; and
generating the functional image by iteratively optimizing successive estimates of the functional image regularized by the preliminary estimate of the functional image weighted by a regularization parameter; and

display the functional image.