Patent ID: 11946029
Assignee: ASTREGO DIAGNOSTICS AB
Field: Chemical engineering (Chemistry)
Classification: CPC B  C  G | IPC B  C

Claim 0:
1. A microfluidic device comprising:
a first fluid port;
a third fluid port;
a substrate having cell channels adapted to accommodate target cells;
a flow input channel having a first end in fluid connection with said first fluid port, wherein a respective first end of said cell channels is in fluid connection with said flow input channel; and
a flow output channel in fluid connection with said third fluid port, wherein a respective second end of said cell channels is in fluid connection with said flow output channel, wherein said cell channels comprise a respective obstruction designed to prevent said target cells from passing said respective obstruction and into said flow output channel and to capture said target cells in said cell channels;
a pre-filter comprising:
a first filter port;
a filter channel having a first end in fluid connection with said first filter port; and
pre-filter channels adapted to accommodate said target cells and capture contaminating particles, wherein a respective first end of said pre-filter channels is in fluid connection with said filter channel and a respective second end of said pre-filter channels is in fluid connection with said flow input channel; and

a flow controller in fluidic connection with the first and third fluid ports and/or the first filter port, wherein the flow controller is configured to induce a fluid flow from said flow input channel through said pre-filter channels and into said filter channel to clean contaminating particles clogging said pre-filter channels and/or blocking entrances of said pre-filter channels.