Patent ID: 11905563
Assignee: THOMAS JEFFERSON UNIVERSITY
Field: Measurement (Instruments)
Classification: CPC C  G | IPC C  G

Claim 0:
1. A method of treating a cancer selected from the group consisting of colon adenocarcinoma (COAD), stomach adenocarcinoma (STAD), rectum adenocarcinoma (READ), esophageal carcinoma (ESCA), pancreatic adenocarcinoma (PAAD), and ovarian carcinoma (OV), said method comprising:
isolating isomiRs or miRNAs from a sample obtained from the subject;
characterizing the isomiRs or miRNAs and their presence or absence in the sample to identify a signature;
evaluating the signature with a multi-cancer classifier, wherein the multi-cancer classifier has been trained using tumor samples from two or more cancers as examples and using qualitative, binarized profiles based on the presence or absence of expression of the isomiRs or miRNAs, wherein the “presence” of expression of the isomiR or miRNA means the isomiR or miRNA is among the top 20% most abundant isomiR or miRNA, and wherein the “absence” of expression of the isomiR or miRNA means the isomiR or miRNA is not among the top 20% most abundant isomiRs or miRNAs; and
determining whether the signature is indicative of any one cancer of COAD, STAD, READ, ESCA, PAAD, or OV, among the two or more cancers; and
administering to the subject a specific chemotherapy specifically targeting said any one cancer of COAD, STAD, READ, ESCA, PAAD, or OV being indicated.