Patent ID: 11872298
Assignee: L'OREAL
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 0:
1. A cosmetic composition comprising as an active ingredient a mixture of arthrofactins comprising
(i) arthrofactin A of the following formula (I):

R1-D-Leu1-D-Asp2-D-allo-Thr3-D-Leu4-D-Leu5-D-Ser6-L-Leu7-D-Ser8-L-Ile9-L-Ile10-L-Asp11  (I),

wherein
the hydroxyl group of the D-allo-Thr3 amino acid residue forms an ester bond with the C-terminal carboxyl group of the L-Asp11 amino acid residue, and
R1 represents the group of the following formula (I′):, wherein R1′ is a saturated alkyl chain with 5 to 8 carbon atoms, and
(ii) at least one derivative of arthrofactin A, said derivative is selected from the group consisting of arthrofactin B, arthrofactin C, arthrofactin D and mixtures thereof,
(a) arthrofactin B being of the following formula (III):

R1-D-Leu1-D-Asp2-D-allo-Thr3-D-Leu4-D-Leu5-D-Ser6-L-Leu7-D-Ser8-L-Ile9-L-Ile10-L-Glu11  (III),

wherein
the hydroxyl group of the D-allo-Thr3 amino acid residue forms an ester bond with the C-terminal carboxyl group of the L-Glu11 amino acid residue, and

R1 represents the group of the following formula (I′):, wherein R1′ is a saturated alkyl chain with 5 to 8 carbon atoms;

(b) arthrofactin C being of the following (IV):

R2-D-Leu1-D-Asp2-D-allo-Thr3-D-Leu4-D-Leu5-D-Ser6-L-Leu7-D-Ser8-L-Ile9-L-Ile10-L-Asp11  (IV),

wherein
the hydroxyl group of the D-allo-Thr3 amino acid residue forms an ester bond with the carboxyl C-terminal group of the L-Asp11 amino acid residue, and

R2 represents the group of the following formula (IV′):, wherein R2′ is an alkyl chain with 9 carbon atoms, comprising exactly one unsaturation;

(c) arthrofactin D being of the following formula (V):

R3-D-Leu1-D-Asp2-D-allo-Thr3-D-Leu4-D-Leu5-D-Ser6-L-Leu7-D-Ser8-L-Ile9-L-Ile10-L-Asp11  (V),

wherein
the hydroxyl group of the D-allo-Thr3 amino acid residue forms an ester bond with the C-terminal carboxyl group of the L-Asp11 amino acid residue, and
R3 represents the group of the following formula (V′):, wherein R3′ is a saturated alkyl chain with 9 carbon atoms;, the composition further comprising a physiologically acceptable medium; wherein the amount of the mixture of arthrofactins is between 0.01 and 10% by weight based upon the weight of the composition and the composition is in the form of an emulsion, a cream, an ointment, a milk, a lotion, a serum, a paste, a gel, a foam or a stick.