Patent ID: 11969567
Assignee: THE SPECTRANETICS CORPORATION
Field: Medical technology (Instruments)
Classification: CPC A | IPC A

Claim 0:
1. A method for treating a target vascular portion of a subject with an angioplasty balloon system including an angioplasty balloon, wherein a surface of the angioplasty balloon carries both:
an amphiphilic polymer and paclitaxel directly on a portion of a surface of the angioplasty balloon, and
pro-resolving mediators directly on the portion of the surface of the angioplasty balloon, wherein the pro-resolving mediators are at least partially encapsulated by a polymeric nanoparticle, the method comprising:
positioning the angioplasty balloon proximate the target vascular portion;
expanding the angioplasty balloon to engage the target vascular portion with the portion of the surface of the angioplasty balloon carrying the paclitaxel and the pro-resolving mediators contacting the target vascular portion, thereby simultaneously delivering both the paclitaxel and the pro-resolving mediators to the target vascular portion upon contact of the portion of the surface of the angioplasty balloon with the target vascular portion, wherein the paclitaxel is taken up into a medial layer of vascular tissue at the target vascular portion, while the pro-resolving mediators remain in contact with an intimal surface of the vascular tissue;
subsequently deflating the angioplasty balloon; and
subsequent to the deflating, withdrawing the angioplasty balloon system from the subject.