Patent ID: 11887302
Assignee: AMGEN INC.
Field: Computer technology (Electrical engineering)
Classification: CPC G | IPC G

Claim 0:
1. A method for detecting cytopathic effect (CPE) in a well sample, the method comprising:
generating, by an imaging unit, a well image depicting a well containing cells and a medium;
pre-processing, by one or more processors, the well image, wherein pre-processing the well image includes partitioning the well image into a plurality of sub-images each corresponding to a different portion of the well;
for each of some or all of the plurality of sub-images, determining, by the one or more processors analyzing the sub-image using a convolutional neural network, a respective score indicative of a likelihood that any cells in the portion of the well corresponding to the sub-image exhibit CPE;
determining, by the one or more processors and based on the respective scores for the plurality of sub-images, a CPE status of the cells contained in the well;
generating, by the one or more processors, output data indicating the CPE status; and
wherein, if the respective score indicative of the likelihood that any cells in the portion of the well corresponding to the sub-image exhibit CPE exceeds a specified threshold, the one or more processors cease the analysis, and the CPE status is determined based on the respective score exceeding the specified threshold.