Patent ID: 11957790
Assignee: nan
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  F | IPC A  F

Claim 12:
13. A method of using a single syringe to both lyophilize a liquid preparation into a lyophilized product and subsequently rehydrate and dispense the lyophilized product in rehydrated form, said method comprising the steps of:
a. introducing said liquid preparation into a hollow interior bore of a lyophilization syringe comprising an elongate central barrel characterized by an exterior surface, an interior surface, and a hollow interior bore configured to retain said liquid preparation and said lyophilized product, an open distal tip configured to engage a hypodermic needle assembly; and an open proximal end configured to removably receive a stopper; and
b. affixing a distal cap to said open distal tip;
c. partially inserting a stopper into the open proximal end of said elongate central barrel to a first axial position so as to form a passage whereby gas may flow out from the central barrel and through a member, wherein said stopper comprises (i) at least one vent channel disposed along a lateral surface that serves as said passage whereby gas may flow out from the central barrel and through said member, (ii) at least one sealing rib circumferentially disposed about said lateral surface at a position that is proximal to a distal end of said at least one vent channel; and (iii) optionally a threaded socket formed in a proximal surface of the stopper;
d. lyophilizing said liquid preparation into said lyophilized product in situ;
e. axially sliding the stopper along the barrel in a distal direction to a second axial position wherein said at least one vent channel is closed and said lyophilized product is sealed within said central barrel.