Patent ID: 11912971
Assignee: SOUTHWEST RESEARCH INSTITUTE
Field: Biotechnology (Chemistry)
Classification: CPC C  B | IPC B  C

Claim 0:
1. A 3D bioreactor for growth of cells comprising
a plurality of voids having a surface area for cell expansion, said plurality of voids having a diameter D, a plurality of pore openings between said voids having a diameter d, such that D>d and wherein: (a) 90% or more of said voids have a selected void volume (V) that does not vary by more than +/−10.0%; and (b) 90% or more of said pore openings between said voids have a value of d that does not vary by more than +/−10.0%;
wherein said bioreactor comprises the polymerization product of the following monomer:, wherein X and Y comprise polymerizable groups that are polymerized by free-radical polymerization or nucleophilic addition, R2 is a bulky organic group having a bulk greater than R1 and R3, wherein R2 is adapted to provide sufficient steric hindrance to achieve a nematic state at room temperature wherein said bioreactor is coated with substituted or unsubstituted poly(p-xylylene wherein polydopamine is applied to said poly(p-xylylene) wherein said polydopamine is capable of binding additional layers for cell culturing.