Patent ID: 11970533
Assignee: SPARX BIOSCIENCE LIMITED
Field: Biotechnology (Chemistry)
Classification: CPC C | IPC C

Claim 0:
1. A bispecific antibody, comprising a first antigen-binding moiety that binds human claudin 18.2, and a second antigen-binding moiety that binds human PD-L1, wherein the first antigen-binding moiety comprises:
(a) a first heavy chain variable domain (VH), which comprises the same heavy chain complementarity-determining regions (CDRs) as a reference anti-human claudin 18.2 antibody; and
(b) a first light chain variable domain (VL), which comprises the same light chain CDRs as the reference anti-human claudin 18.2 antibody; and
wherein the reference anti-human claudin 18.2 antibody has a heavy chain and a light chain comprising the following amino acid sequences, respectively:
(1) SEQ ID NOs: 15 and 16,
(2) SEQ ID NOs: 20 and 16,
(3) SEQ ID NOs: 26 and 27,
(4) SEQ ID NOs: 33 and 34,
(5) SEQ ID NOs: 37 and 38,
(6) SEQ ID NOs: 42 and 43,
(7) SEQ ID NOs: 48 and 49,
(8) SEQ ID NOs: 54 and 55,
(9) SEQ ID NOs: 58 and 16,
(10) SEQ ID NOs: 60 and 61,
(11) SEQ ID NOs: 63 and 64,
(12) SEQ ID NOs: 67 and 68,
(13) SEQ ID NOs: 70 and 71,
(14) SEQ ID NOs: 73 and 74,
(15) SEQ ID NOs: 76 and 77,
(16) SEQ ID NOs: 79 and 61,
(17) SEQ ID NOs: 81 and 64,
(18) SEQ ID NOs: 83 and 68,
(19) SEQ ID NOs: 85 and 71,
(20) SEQ ID NOs: 86 and 74,
(21) SEQ ID NOs: 87 and 77,
(22) SEQ ID NOs: 88 and 55,
(23) SEQ ID NOs: 89 and 43,
(24) SEQ ID NOs: 91 and 92,
(25) SEQ ID NOs: 94 and 95, or
(26) SEQ TD NOs: 96 and 95.