Patent ID: 11970547
Assignee: GC CELL CORPORATION
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A chimeric antigen receptor targeting human HER2, the chimeric antigen receptor comprising an amino acid sequence comprising, from N- to C-terminus:
an extracellular antigen binding domain comprising a heavy chain variable region comprising the amino acid sequences of SEQ ID NO: 7, SEQ ID NO: 8, and SEQ ID NO: 9, and a light chain variable region comprising the amino acid sequences of SEQ ID NO: 10, SEQ ID NO: 11, and SEQ ID NO: 12;
a CD8a hinge domain;
a CD28 transmembrane domain; and
an intracellular signaling domain comprising:
(i) a CD28 intracellular signaling domain,
(ii) a OX4OL intracellular signaling domain, and
(iii) a CD3z intracellular signaling domain.