Patent ID: 11952408
Assignee: JUNO THERAPEUTICS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A polynucleotide, comprising:
(a) a nucleic acid sequence encoding a T cell receptor (TCR) or an antigen-binding portion thereof that binds to or recognizes a peptide epitope of human papillomavirus (HPV) 16 in the context of an MHC molecule, and
(b) two or more homology arm(s) linked to the nucleic acid sequence, wherein: the two or more homology arms comprise a sequence homologous to one or more region(s) of an open reading frame of a T cell receptor alpha constant (TRAC) locus;
wherein the two or more homology arm(s) comprises a 5′ homology arm and a 3′ homology arm,
wherein the 5′ homology arm comprises the sequence set forth in SEQ ID NO: 1343, and
wherein the 3′ homology arm comprises a sequence comprising at least 150 contiguous nucleotides of the sequence set forth in SEQ ID NO: 1344.