Patent ID: 11945806
Assignee: nan
Field: Organic fine chemistry (Chemistry)
Classification: CPC C  A | IPC C

Claim 0:
1. A method of stabilizing an immunoglobulin light chain dimer in a native conformation thereof, comprising contacting the dimer and an effective amount of a compound of Formula Ia, or a pharmaceutically acceptable salt thereof:, wherein
A is, X1 is O or NR0;
X2 is selected from the group consisting of a bond, NR12, O, C(O), C(O)NR11, and CR12R11;
X3 is O or NR13;
W is, m is an integer selected from 1, 2, 3, 4, 5, and 6;
n is an integer selected from 0, 1, 2, 3, 4, 5, and 6;
p is an integer selected from 0, 1, 2, 3, 4, 5, and 6;
r is an integer selected from 0, 1, 2, and 3;
Z1 is selected from the group consisting of
H,
C1-C6-alkyl,
C3-C8-cycloalkyl,
3- to 6-membered heterocycloalkyl wherein 1-4 ring members are independently selected from N, O, and S,
C2-C6-alkenyl,
C3-C8-cycloalkenyl,
3- to 6-membered heterocycloalkenyl wherein 1-4 ring members are independently selected from N, O, and S,
C6-C10-aryl,
5- to 10-membered heteroaryl wherein 1-4 heteroaryl members are independently selected from N, O, and S,
—(C1-C6-alkyl)(C6-C10-aryl),
—(C1-C6-alkyl)(5- to 10-membered heteroaryl) wherein 1-4 heteroaryl members are independently selected from N, O, and S,
halogen,
NR16NR17,
COOR18;
OR18,
NR16SO2R18,
NR16COR18,
X4(CR21R22)aCONR16R17,
X4(CR21R22)aCOOR18,
X4(CR21R22)aCOR18,
X4(CR21R22)aNR16R17,
X4(CR21R22)aOR18,
SO2NR16R17,
X4(CR21R22)aNR16COR18,
C(N═R23)NR24OH, and, wherein
X4 is a bond, O, or NR0; and
a is an integer selected from 0, 1, 2, 3, 4, 5, and 6;

Z2 is selected from the group consisting of
H,
C1-C6-alkyl,
C3-C8-cycloalkyl,
3- to 6-membered heterocycloalkyl wherein 1-4 ring members are independently selected from N, O, and S,
C2-C6-alkenyl,
C2-C6-alkynyl,
C3-C8-cycloalkenyl,
3- to 6-membered heterocycloalkenyl wherein 1-4 ring members are independently selected from N, O, and S,
C6-C10-aryl,
5- to 10-membered heteroaryl wherein 1-4 heteroaryl members are independently selected from N, O, and S,
—(C1-C6-alkyl)(C6-C10-aryl),
—(C1-C6-alkyl)(5- to 10-membered heteroaryl) wherein 1-4 heteroaryl members are independently selected from N, O, and S,
CN,
OR18 and
NR19R20;

Ar1 is a divalent moiety selected from
C6-C10-arylene and
5- to 10-membered heteroarylene wherein 1-4 heteroaryl members are independently selected from N, O, and S;

R1 is selected from the group consisting of
H,
C1-C6-alkyl,
C3-C8-cycloalkyl,
3- to 6-membered heterocycloalkyl wherein 1-4 ring members are independently selected from N, O, and S,
C2-C6-alkenyl,
C3-C8-cycloalkenyl,
3- to 6-membered heterocycloalkenyl wherein 1-4 ring members are independently selected from N, O, and S,
C6-C10-aryl,
5- to 10-membered heteroaryl wherein 1-4 heteroaryl members are independently selected from N, O, and S,
—(C1-C6-alkyl)(C6-C10-aryl),
—(C1-C6-alkyl)(5- to 10-membered heteroaryl) wherein 1-4 heteroaryl members are independently selected from N, O, and S,
OH,
(CR21R22)bOR18 where b is an integer selected from 0, 1, 2, 3, 4, 5, and 6,
halogen, and
(C1-C6)haloalkyl;

R2, R3, and R4 are independently selected from the group consisting of
H,
C1-C6-alkyl,
—(C1-C6-alkyl)(C6-C10-aryl),
OH,
(CR21R22)bOR18,
halogen,
C3-C8-cycloalkyl,
3- to 6-membered heterocycloalkyl wherein 1-4 ring members are independently selected from N, O, and S,
C2-C6-alkenyl,
C3-C8-cycloalkenyl,
3- to 6-membered heterocycloalkenyl wherein 1-4 ring members are independently selected from N, O, and S,
C6-C10-aryl,
5- to 10-membered heteroaryl wherein 1-4 heteroaryl members are independently selected from N, O, and S,
—(C1-C6-alkyl)(C6-C10-aryl), and
—(C1-C6-alkyl)(5- to 10-membered heteroaryl) wherein 1-4 heteroaryl members are independently selected from N, O, and S;

R0, R5-R13 and R18-R22 are independently selected from the group consisting of H,
C1-C6-alkyl,
C1-C6-haloalkyl,
C3-C8-cycloalkyl,
3- to 6-membered heterocycloalkyl wherein 1-4 ring members are independently selected from N, O, and S,
C2-C6-alkenyl,
C2-C6-alkynyl,
C3-C8-cycloalkenyl,
3- to 6-membered heterocycloalkenyl wherein 1-4 ring members are independently selected from N, O, and S,
C6-C10-aryl,
5- to 10-membered heteroaryl wherein 1-4 heteroaryl members are independently selected from N, O, and S,
—(C1-C6-alkyl)(C6-C10-aryl), and
—(C1-C6-alkyl)(5- to 10-membered heteroaryl) wherein 1-4 heteroaryl members are independently selected from N, O, and S;

R16 and R17 are independently selected from the group consisting of H,
C1-C6-alkyl,
C3-C8-cycloalkyl,
3- to 6-membered heterocycloalkyl wherein 1-4 ring members are independently selected from N, O, and S,
C2-C6-alkenyl,
C3-C8-cycloalkenyl,
3- to 6-membered heterocycloalkenyl wherein 1-4 ring members are independently selected from N, O, and S,
C6-C10-aryl,
5- to 10-membered heteroaryl 4 wherein 1-4 heteroaryl members are independently selected from N, O, and S,
—(C1-C6-alkyl)(C6-C10-aryl),
—(C1-C6-alkyl)(5- to 10-membered heteroaryl) wherein 1-4 heteroaryl members are independently selected from N, O, and S,
C(O)OR18,
C(O)R18, and
SO2R18;

R16 and R17, together with the atoms to which they are bound, optionally are a 3- to 8-membered ring wherein ring members are selected from C, O and N;
R19 and R20, together with the atoms to which they are bound, optionally are a 3- to 8-membered ring;
R21 and R22, together with the atoms to which they are bound, optionally are a 3- to 8-membered ring.