Patent ID: 11944602
Assignee: NOVARTIS AG
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 28:
29. A method of treating an autoimmune disease in a patient receiving a chronic beta-blocker treatment and having a resting heart rate of ≤50 bpm under said chronic beta-blocker treatment comprising
a) interrupting said chronic beta-blocker treatment in said patient until the baseline heart-rate is >50 bpm;
b) initiating in said patient a siponimod treatment by
b1) administering to said patient an initial titration regimen of siponimod; and
b2) administering to said patient 1-15 mg siponimod daily as a maintenance regimen; and
c) re-initiating in said patient a beta-blocker treatment the earliest at the first day when said patient is receiving the dosage of the maintenance regimen;
wherein said initial titration regimen comprises administering siponimod at a dosage lower than the dosage of the maintenance regimen and then increasing the dosage stepwise up to the dosage of the maintenance regimen.