Patent ID: 11912993
Assignee: SILENCE THERAPEUTICS GMBH
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A compound having formula (II):

[S—X1—P—X2]3-A-X3—Z  (II), wherein:
S represents a saccharide;
X1 represents C3-6 alkylene or an ethylene glycol stem (—CH2—CH2-O)m(—CH2)2−wherein m is 1, 2, or 3;
P is, , wherein Y1 and Y2 ach independently represent═O, ═S, —O−, —OH, —SH, —BH3, —OCH2CO2, —OCH2CO2Rx, —OCH2C(S)ORx, or —ORx, wherein Rx represents C1C6 alkyl and
wherein, , indicates attachment to the remainder of the compound;
X2 is C1-C8 alkylene;
A is a branching unit selected from:, X3 is selected from the group consisting of —CH2—O—C4H8, —CH2—O—C6H12— and —CH2−O—C8 H16−;
Z is a nucleic acid comprising two strands comprising nucleotides, that is able to interfere with gene expression;
and where the linkage between X3 and Z is a phosphate or thiophosphate.