Patent ID: 11866509
Assignee: FAMEWAVE LTD.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C  G | IPC A  C  G

Claim 0:
1. A pharmaceutical composition comprising a humanized monoclonal antibody (mAb) or a fragment thereof, which specifically recognizes human Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), wherein the mAb or fragment thereof comprises:
(i) a heavy-chain variable region amino-acid sequence comprising the three CDR sequences set forth in SEQ ID NO:1, SEQ ID NO:2 and SEQ ID NO:3 and the four framework sequences set forth in: (a) SEQ ID NO:7 or SEQ ID NO:15; (b) SEQ ID NO:16 or SEQ ID NO:17; (c) SEQ ID NO:18, SEQ ID NO:19, SEQ ID NO:20, SEQ ID NO:21 or SEQ ID NO:22; and (d) SEQ ID NO:10 or SEQ ID NO:23;
and
(ii) a light-chain variable region amino-acid sequence comprising the three CDR sequences set forth in SEQ ID NO:4, SEQ ID NO:5 and SEQ ID NO:6, and the four framework sequences set forth in: (a) SEQ ID NO:11; (b) SEQ ID NO:24; (c) SEQ ID NO:25, SEQ ID NO:26 or SEQ ID NO:27; and (d) SEQ ID NO:14;, and a pharmaceutically acceptable carrier, diluent or excipient.