Patent ID: 11920131
Assignee: TORAY INDUSTRIES, INC.
Field: Biotechnology (Chemistry)
Classification: CPC C | IPC C

Claim 10:
11. The method according to claim 1, wherein the first single-stranded oligoRNA molecule and the second single-stranded oligoRNA molecule are any of (1) to (21):
(1) a combination of the first single-stranded oligoRNA molecule consisting of the nucleotide sequence set forth in SEQ ID NO: 7 in which ribonucleotide residues at positions 24 and 25 are connected via the first linker and the second single-stranded oligoRNA molecule consisting of the nucleotide sequence set forth in SEQ ID NO: 6 in which ribonucleotide residues at positions 10 and 11 are connected via the second linker;
(2) a combination of the first single-stranded oligoRNA molecule consisting of a nucleotide sequence set forth in SEQ ID NO: 19 in which ribonucleotide residues at positions 24 and 25 are connected via the first linker and the second single-stranded oligoRNA molecule consisting of the nucleotide sequence set forth in SEQ ID NO: 18 in which ribonucleotide residues at positions 16 and 17 are connected via the second linker;
(3) a combination of the first single-stranded oligoRNA molecule consisting of the nucleotide sequence set forth in SEQ ID NO: 27 in which ribonucleotide residues at positions 24 and 25 are connected via the first linker and the second single-stranded oligoRNA molecule consisting of the nucleotide sequence set forth in SEQ ID NO: 26 in which ribonucleotide residues at positions 20 and 21 are connected via the second linker;
(4) a combination of the first single-stranded oligoRNA molecule consisting of a nucleotide sequence set forth in SEQ ID NO: 29 in which ribonucleotide residues at positions 24 and 25 are connected via the first linker and the second single-stranded oligoRNA molecule consisting of the nucleotide sequence set forth in SEQ ID NO: 28 in which ribonucleotide residues at positions 21 and 22 are connected via the second linker;
(5) a combination of the first single-stranded oligoRNA molecule consisting of a nucleotide sequence set forth in SEQ ID NO: 31 in which ribonucleotide residues at positions 24 and 25 are connected via the first linker and the second single-stranded oligoRNA molecule consisting of the nucleotide sequence set forth in SEQ ID NO: 30 in which ribonucleotide residues at positions 22 and 23 are connected via the second linker;
(6) a combination of the first single-stranded oligoRNA molecule consisting of a nucleotide sequence set forth in SEQ ID NO: 33 in which ribonucleotide residues at positions 24 and 25 are connected via the first linker and the second single-stranded oligoRNA molecule consisting of the nucleotide sequence set forth in SEQ ID NO: 32 in which ribonucleotide residues at positions 23 and 24 are connected via the second linker;
(7) a combination of the first single-stranded oligoRNA molecule consisting of the nucleotide sequence set forth in SEQ ID NO: 5 in which ribonucleotide residues at positions 24 and 25 are connected via the first linker and the second single-stranded oligoRNA molecule consisting of the nucleotide sequence set forth in SEQ ID NO: 4 in which ribonucleotide residues at positions 9 and 10 are connected via the second linker;
(8) a combination of the first single-stranded oligoRNA molecule consisting of the nucleotide sequence set forth in SEQ ID NO: 9 in which ribonucleotide residues at positions 24 and 25 are connected via the first linker and the second single-stranded oligoRNA molecule consisting of the nucleotide sequence set forth in SEQ ID NO: 8 in which ribonucleotide residues at positions 11 and 12 are connected via the second linker;
(9) a combination of the first single-stranded oligoRNA molecule consisting of the nucleotide sequence set forth in SEQ ID NO: 11 in which ribonucleotide residues at positions 24 and 25 are connected via the first linker and the second single-stranded oligoRNA molecule consisting of the nucleotide sequence set forth in SEQ ID NO: 10 in which ribonucleotide residues at positions 12 and 13 are connected via the second linker;
(10) a combination of the first single-stranded oligoRNA molecule consisting of the nucleotide sequence set forth in SEQ ID NO: 13 in which ribonucleotide residues at positions 24 and 25 are connected via the first linker and the second single-stranded oligoRNA molecule consisting of the nucleotide sequence set forth in SEQ ID NO: 12 in which ribonucleotide residues at positions 13 and 14 are connected via the second linker;
(11) a combination of the first single-stranded oligoRNA molecule consisting of the nucleotide sequence set forth in SEQ ID NO: 15 in which ribonucleotide residues at positions 24 and 25 are connected via the first linker and the second single-stranded oligoRNA molecule consisting of the nucleotide sequence set forth in SEQ ID NO: 14 in which ribonucleotide residues at positions 14 and 15 are connected via the second linker;
(12) a combination of the first single-stranded oligoRNA molecule consisting of the nucleotide sequence set forth in SEQ ID NO: 17 in which ribonucleotide residues at positions 24 and 25 are connected via the first linker and the second single-stranded oligoRNA molecule consisting of the nucleotide sequence set forth in SEQ ID NO: 16 in which ribonucleotide residues at positions 15 and 16 are connected via the second linker;
(13) a combination of the first single-stranded oligoRNA molecule consisting of the nucleotide sequence set forth in SEQ ID NO: 21 in which ribonucleotide residues at positions 24 and 25 are connected via the first linker and the second single-stranded oligoRNA molecule consisting of the nucleotide sequence set forth in SEQ ID NO: 20 in which ribonucleotide residues at positions 17 and 18 are connected via the second linker;
(14) a combination of the first single-stranded oligoRNA molecule consisting of the nucleotide sequence set forth in SEQ ID NO: 23 in which ribonucleotide residues at positions 24 and 25 are connected via the first linker and the second single-stranded oligoRNA molecule consisting of the nucleotide sequence set forth in SEQ ID NO: 22 in which ribonucleotide residues at positions 18 and 19 are connected via the second linker;
(15) a combination of the first single-stranded oligoRNA molecule consisting of the nucleotide sequence set forth in SEQ ID NO: 25 in which ribonucleotide residues at positions 24 and 25 are connected via the first linker and the second single-stranded oligoRNA molecule consisting of the nucleotide sequence set forth in SEQ ID NO: 24 in which ribonucleotide residues at positions 19 and 20 are connected via the second linker;
(16) a combination of the first single-stranded oligoRNA molecule consisting of the nucleotide sequence set forth in SEQ ID NO: 35 in which ribonucleotide residues at positions 24 and 25 are connected via the first linker and the second single-stranded oligoRNA molecule consisting of the nucleotide sequence set forth in SEQ ID NO: 34 in which ribonucleotide residues at positions 20 and 21 are connected via the second linker;
(17) a combination of the first single-stranded oligoRNA molecule consisting of a nucleotide sequence set forth in SEQ ID NO: 37 in which ribonucleotide residues at positions 22 and 23 are connected via the first linker and the second single-stranded oligoRNA molecule consisting of the nucleotide sequence set forth in SEQ ID NO: 36 in which ribonucleotide residues at positions 20 and 21 are connected via the second linker;
(18) a combination of the first single-stranded oligoRNA molecule consisting of the nucleotide sequence set forth in SEQ ID NO: 39 in which ribonucleotide residues at positions 24 and 25 are connected via the first linker and the second single-stranded oligoRNA molecule consisting of the nucleotide sequence set forth in SEQ ID NO: 38 in which ribonucleotide residues at positions 16 and 17 are connected via the second linker;
(19) a combination of the first single-stranded oligoRNA molecule consisting of the nucleotide sequence set forth in SEQ ID NO: 41 in which ribonucleotide residues at positions 24 and 25 are connected via the first linker and the second single-stranded oligoRNA molecule consisting of the nucleotide sequence set forth in SEQ ID NO: 40 in which ribonucleotide residues at positions 22 and 23 are connected via the second linker;
(20) a combination of the first single-stranded oligoRNA molecule consisting of the nucleotide sequence set forth in SEQ ID NO: 47 in which ribonucleotide residues at positions 24 and 25 are connected via the first linker and the second single-stranded oligoRNA molecule consisting of the nucleotide sequence set forth in SEQ ID NO: 46 in which ribonucleotide residues at positions 21 and 22 are connected via the second linker; and
(21) a combination of the first single-stranded oligoRNA molecule consisting of the nucleotide sequence set forth in SEQ ID NO: 49 in which ribonucleotide residues at positions 24 and 25 are connected via the first linker and the second single-stranded oligoRNA molecule consisting of the nucleotide sequence set forth in SEQ ID NO: 48 in which ribonucleotide residues at positions 23 and 24 are connected via the second linker.