Patent ID: 11939334
Assignee: UPPTHERA, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 5:
6. The compound according to claim 1, or a pharmaceutically acceptable salt or stereoisomer thereof, wherein:
LU is a bond, —(CH2)x—, —(CH2)xO—, —C(O)—, or phenylene;
L1 is a bond or 4- to 12-membered heterocycloalkylene;
wherein the 4- to 12-membered heterocycloalkylene is monocyclic, bridged bicyclic, or spirocyclic;
wherein the 4- to 12-membered heterocycloalkylene contains at least one nitrogen ring heteroatom;
wherein the 4- to 12-membered heterocycloalkylene is bonded to LU or ring U via the nitrogen ring heteroatom; and
wherein the 4- to 12-membered heterocycloalkylene is optionally substituted with one or more substituents independently selected from halo, C1-4 alkyl, OH, or ═O;

L2 is —(CH2)y1—, —(CH2)y2—C(O)—(CH2)y3—, —(CH2)y2—NH—(CH2)y3—, or —(CH2)y2—N(C1-4 alkyl)-(CH2)y3—;
L3 is a bond, 4- to 6-membered cycloalkylene or 4- to 12-membered heterocycloalkylene;
wherein the 4- to 12-membered heterocycloalkylene is monocyclic, bridged bicyclic, or spirocyclic;
wherein the 4- to 12-membered heterocycloalkylene contains at least one nitrogen ring heteroatom; and
wherein the 4- to 6-membered cycloalkylene or 4- to 12-membered heterocycloalkylene is optionally substituted with one or more independently selected halo substituents;

LP is —(CH2)p—NH—C(O)— or —(CH2)p—O—C(O)—, wherein the —C(O)— of LP is bonded to the ring bearing R6;
p is 0 or 1;
x is 0 or 1;
y1 is 0, 1, 2, or 3;
y2 is 0, 1, 2, or 3; and
y3 is 0, 1, 2, or 3.