Patent ID: 11945878
Assignee: ABCLON INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC C

Claim 0:
1. A switch molecule for activating a chimeric antigen receptor-effector cell, the molecule comprising:
a targeting moiety binding to a cell surface molecule on a target cell; and
an affibody specifically binding to an extracellular domain of the chimeric antigen receptor (CAR) on the effector cell, wherein
the switch molecule comprises an amino acid sequence selected from the group consisting of:
i) the amino acid sequence of SEQ ID NO: 10;
ii) the amino acid sequence of SEQ ID NO: 10, wherein amino acids 74 to 131 of SEQ ID NO: 10 are replaced with amino acids 1 to 58 of SEQ ID NO: 4;
iii) the amino acid sequence of SEQ ID NO: 12;
iv) the amino acid sequence of SEQ ID NO: 12, wherein amino acids 259 to 316 are replaced with amino acids 1 to 58 of SEQ ID NO: 4;
v) the amino acid sequence of SEQ ID NO: 14;
vi) the amino acid sequence of SEQ ID NO: 14, wherein amino acids 466 to 523 are replaced with amino acids 1 to 58 of SEQ ID NO: 4;
vii) the amino acid sequence of SEQ ID NO: 18;
viii) the amino acid sequence of SEQ ID NO: 20;
ix) the amino acid sequence of SEQ ID NO: 22; and
x) the amino acid sequence of SEQ ID NO: 24.