Patent ID: 11939575
Assignee: CITY OF HOPE
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 8:
9. The method of claim 8, wherein:
(a) said RNA-guided DNA endonuclease enzyme is Cas9 or Cpf1 or a Class II CRISPR endonuclease or a variant thereof;
(b) said RNA-guided DNA endonuclease enzyme is a modified Cas endonuclease;
(c) said RNA-guided DNA endonuclease enzyme is deactivated Cas9 (dCas9) or mutated Cas9 nickase (D10A);
(d) said RNA-guided DNA endonuclease enzyme is a conjugate comprising a Cas 9 endonuclease and a transcription regulating factor; or
(e) said RNA-guided DNA endonuclease enzyme comprises a dCas-APOBEC3A fusion protein, a dCas-VPR fusion protein or a dCas-KRAB fusion protein.