Patent ID: 11873307
Assignee: NOVARTIS AG
Field: Organic fine chemistry (Chemistry)
Classification: CPC C  A  Y | IPC C

Claim 12:
13. The method of claim 2, wherein the compound of formula IV is a compound of formula XIII:, , wherein R1 is a secondary amino protecting group and R2 is a protected amino group;
wherein the compound of formula XIII is obtained by reducing a compound of formula X:, , wherein R1 is a secondary amino protecting group and R2 is a protected amino group, to yield a compound of formula XI:, , wherein R1 is a secondary amino protecting group and R2 is a protected amino group;
reacting the compound of formula XI with a leaving group forming agent of the formula LG*-X wherein LG* is an electrophilic radical capable of forming, with a hydroxy to which it is bound, a leaving group LG2, and X is halogen, to yield a compound of formula XII:, , wherein R1 is a secondary amino protecting group, R2 is a protected amino group, and LG2 is a leaving group; and
cyclizing the compound of formula XII under basic conditions to yield the compound of formula XIII.