Patent ID: 11963936
Assignee: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 0:
1. A method of manufacturing a composition comprising:
mixing a biologically active agent;
a first oil;
a second oil;
a non-ionic surfactant; and
water to form an emulsion; where the first oil and the second oil are present in the composition in an amount effective to reduce the amount of biologically active agent in an aqueous phase to less than 80 wt % of the amount with just the first oil present in an otherwise identical composition at the same total oil loading;
where the composition forms average domain particle size droplets of 100 nanometers to 1 micrometer as determined by dynamic light scattering;
where the biologically active agent is present in an amount of 0.5 to 5 wt %;
where the biologically active agent is selected from propofol, sodium thiopental, or any combination thereof;
where the first oil comprises at least one triglyceride and is present in an amount of 3 to 10 wt %;
where the second oil is a simple fatty acid or simple fatty acid ester and is present in an amount of 3 to 10 wt %;
where the non-ionic surfactant is present in an amount of 1 to 5 wt %;
where the non-ionic surfactant is selected from a poloxamer, a polysorbate, polyoxyethylene glycol alkyl ether, or any combination thereof;
where the water is present in an amount of 50 to 90 wt %; and
where the wt % is based on the total weight of the composition.