Patent ID: 11964973
Assignee: BRISTOL-MYERS SQUIBB COMPANY
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC C

Claim 0:
1. A compound of Formula (I):, or a salt thereof, wherein:
X is or N;
Y is CR3 or N;
L is —O—, —S—, —S(O)2—, —NR4c—, or —NR4dC(O)—;
R1 is H, F, Cl, Br, —CN, C1-3 alkyl substituted with zero to 4 R1a, C3-4 cycloalkyl substituted with zero to 4 R1a, C1-3 alkoxy substituted with zero to 4 R1a, —C(O)NRaRa, —NRaRa, —S(O)nRe, or —P(O)ReRe;
each R1a is independently F, Cl, —CN, —OH, —OCH3, or —NRaRa;
each Ra is independently H or C1-3 alkyl;
each Re is independently C3-4 cycloalkyl or C1-3 alkyl substituted with zero to 4 R1a;
R2 is H, C1-3 alkyl substituted with zero to 4 R2a, C2-3 alkenyl substituted with zero to 4 R2a, or C3-4 cycloalkyl substituted with zero to 4 R2a;
each R2a is independently F, Cl, —CN, —OH, —O(C1-2 alkyl), C3-4 cycloalkyl, C3-4 alkenyl, or C3-4 alkynyl;
R3 is H, F, Cl, Br, —CN, C1-3 alkyl, C1-2 fluoroalkyl, C3-4 cycloalkyl, C3-4 fluorocycloalkyl, —NO2, or pyridinyl substituted with zero to 2 R3a;
each R3a is halo, —CN, C1-3 alkyl, or C1-3 alkoxy;
R4 is R4a, —CH2R4a, or —CH2CH2R4a;
R4a is C3-6 cycloalkyl, C5-14 heterocyclyl, C6-10 aryl, or C5-14 heteroaryl, each substituted with zero to 4 R4b;
each R4b is independently F, Cl, Br, —CN, —OH, C1-6 alkyl, C1-3 fluoroalkyl, C1-4 hydroxyalkyl, —(CH2)1-2O(C1-3 alkyl), C1-4 alkoxy, —O(C1-4 hydroxyalkyl), C1-3 fluoroalkoxy, —OCH2CH═CH2, —OCH2C≡CH, —C(O)(C1-4 alkyl), —C(O)OH, —C(O)O(C1-4 alkyl), —C(O)NH2, —C(O)NH(C1-4 alkyl), —C(O)N(C1-4 alkyl)2, —NRcRc, —NRaS(O)2(C1-3 alkyl), —NRaC(O)(C1-3 alkyl), —NRaC(O)O(C1-4 alkyl), —P(O)(C1-3 alkyl)2, —S(O)2(C1-3 alkyl), —O(CH2)1-2(C3-6 cycloalkyl), —O(CH2)1-2(morpholinyl), C3-6 cycloalkyl, cyanocyclopropyl, methylazetidinyl, acetylazetidinyl, triazolyl, tetrahydropyranyl, morpholinyl, thiophenyl, methylpiperidinyl, or —CRcRc(phenyl);
each Rc is independently H or C1-2 alkyl;
R4c is H, C1-6 alkyl, or R4a;
R4d is H or C1-6 alkyl;
each R5 is independently F, Cl, —CN, —OH, C1-6 alkyl substituted with zero to 4 Rg, C1-3 alkoxy substituted with zero to 4 Rg, C2-4 alkenyl substituted with zero to 4 Rg, C2-4 alkynyl substituted with zero to 4 Rg, —(CH2)1-2(C3-4 cycloalkyl substituted with zero to 4 Rg), phenyl substituted with zero to 4 Rg, oxadiazolyl substituted with zero to 3 Rg, pyridinyl substituted with zero to 4 Rg, —(CH2)1-2(heterocyclyl substituted with zero to 4 Rg), —(CH2)1-2NRcC(O)(C1-4 alkyl), —(CH2)1-2NRcC(O)O(C1-4 alkyl), —O(CH2)1-2(heterocyclyl substituted with zero to 4 Rg), —(CH2)1-2NRcS(O)2(C1-4 alkyl), —C(O)(C1-4 alkyl), —C(O)OH, —C(O)O(C1-4 alkyl), —C(O)O(C3-4 cycloalkyl), —C(O)NRaRa, or —C(O)NRa(C3-4 cycloalkyl), or two R5 attached to the same carbon atom form ═O;
each Rg is independently F, Cl, —CN, —OH, C1-3 alkoxy, C1-3 fluoroalkoxy, —O(CH2)1-2O(C1-2 alkyl), C3-5 cycloalkyl, or —NRcRc;
each R6 is H, F, Cl, —CN, —CH3, —CH2F, —CHF2, —CF3, or —OCH3;
R7 is H or —CH3;
m is zero, 1, 2, or 3; and
n is zero, 1, or 2.