Patent ID: 11859176
Assignee: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
Field: Measurement (Instruments)
Classification: CPC C  G | IPC A  C  G

Claim 0:
1. A method for in vitro activation and/or expansion of immune cells, comprising:
a) providing magnetic particles, wherein surfaces of each of the magnetic particles are multi-protrusive and modified with at least one type of immuno-inducing substance, and wherein each of the magnetic particles comprises a copolymer core, a polymer layer, a magnetic substance layer, and a silicon-based layer from the inside to the outside;
b) providing a cell solution, wherein the cell solution comprises at least one type of immune cell; and
c) bringing the magnetic particles in contact with the cell solution such that the at least one type of immuno-inducing substance on the surface of each of the magnetic particles activates and/or expands the at least one type of immune cell in the cell solution, wherein surfaces of the copolymer core comprise a plurality of protrusions which are irregularly shaped, and the average height of the plurality of protrusions that is the average value of a vertical distance of a top side of each protrusion to a connection line between two bottom sides of each protrusion is 300 nm to 1000 nm.