Patent ID: 11890273
Assignee: SCIENTURE, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 19:
20. An oral pharmaceutical composition comprising:
i.) about 1 mg/mL to about 10 mg/mL of losartan or a pharmaceutically acceptable salt thereof,
ii.) about 0.5 mg/mL to about 1.5 mg/mL of a suspending agent selected from the group consisting of hydroxyethylcellulose, methylcellulose, hydroxymethylcellulose, hydroxypropylmethylcellulose, microcrystalline cellulose, sodium carboxymethylcellulose, xanthan gum, acacia, an alginate, and guar gum, or a combination thereof,
iii.) a pH modifying agent, and
iv.) about 0.1 mg/mL to about 3 mg/mL of a preservative,
wherein the pharmaceutical composition is a suspension,
wherein the suspension has a pH of about 7, and
wherein the suspension has the following characteristics after storage at room temperature and 60% relative humidity:
after 12 months of storage, the suspension comprises less than about 0.5 wt/wt % losartan impurity D and losartan impurity E, relative to the weight of losartan in the suspension, and
after 12 months of storage, the suspension comprises at least about 95% of the losartan that was in the suspension prior to storage.