Patent ID: 11925693
Assignee: nan
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C  B | IPC A  B  C

Claim 4:
5. A method of treating melanoma or colon cancer, comprising the step of administering a therapeutically effective dose of a composition for the delivery of immunotherapeutic agents, comprising:
a polymeric nanoparticle comprising:
poly(lactic-co-glycolic)acid (PLGA);
a payload comprising an effective dose of IL-2, PAM3CSK4, and L18-MDP; and
an agonistic anti-CD28 antibody,

wherein:
the polymeric nanoparticle encapsulates the payload, the antibody is conjugated to the surface of the polymeric nanoparticle, IL-2 is present at a concentration of up to 50 lag/kg body weight and the weight:weight:weight ratio of IL-2: PAM3CSK4:L18-MDP is 1:2:2; 1:1:1; 1:2:1; 1:1:2; 1:3:3; 1:2:3; 1:3:2; 1:1:3; or 1:3:1.