Patent ID: 11958887
Assignee: THE GENERAL HOSPITAL CORPORATION
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 0:
1. A protein, comprising a hamartin binding region and a GTPase-activating protein (GAP) region, wherein said protein comprises: (i) a hamartin binding region having at least 94% sequence identity to SEQ ID NO: 2, (ii) a GTPase-activating protein (GAP) region having at least 93% sequence identity to SEQ ID NO: 3, and iii) a spacer sequence linking the hamartin binding region to the GAP region, wherein the spacer sequence comprises SGGG (SEQ ID NO: 13), and wherein said protein lacks amino acids 451-1514 of human tuberin (SEQ ID NO: 10).