Patent ID: 11933771
Assignee: SHIMADZU CORPORATION
Field: Measurement (Instruments)
Classification: CPC G | IPC G

Claim 2:
3. An analysis control device that that controls a liquid chromatograph including a first liquid sender, a second liquid sender, a sample introducer, an analysis column, a junction and a fluorescence detector, comprising
a first liquid sending controller that controls the first liquid sender such that a mobile phase is supplied to the fluorescence detector through the analysis column and the unction during an analysis of a sample;
a second liquid sending controller that controls the second liquid sender such that a fluorescent reaction liquid is supplied to the fluorescence detector through the junction during the analysis of the sample;
a sample introduction controller that controls the sample introducer such that the sample is introduced into the mobile phase by the sample introducer at a position farther upstream than the analysis column during the analysis of the sample;
a generator that generates a chromatogram based on an output signal of the fluorescence detector during the analysis of the sample; and
a supply period determiner that determines a period from a point in time at which the second liquid sender starts supplying the fluorescent reaction liquid to a point in time at which the second liquid sender ends supplying the fluorescent reaction liquid as a supply period during determination of an analysis condition,
wherein the second liquid sending controller causes the second liquid sender to start supplying the fluorescent reaction liquid such that the fluorescent reaction liquid arrives at the junction later than a point in time at which supply of the mobile phase starts and before the sample introduced into the mobile phase arrives at the junction, and causes the second liquid sender to stop supplying the fluorescent reaction liquid after the sample passes through the junction,
the second liquid sending controller causes the second liquid sender to start supplying the fluorescent reaction liquid at the start point in time of the determined supply period and causes the second liquid sender to stop supplying the fluorescent reaction liquid at the end point in time of the supply period during the analysis of the sample,
the first and second liquid sending controllers control the first liquid sender such that the mobile phase is supplied to the fluorescence detector through the analysis column and the junction, and controls the first and second liquid senders such that the fluorescence reaction liquid is supplied to the fluorescence detector through the junction, during the determination of the analysis condition,
the sample introduction controller controls the sample introducer such that the sample is introduced into the mobile phase by the sample introducer at a position farther upstream than the analysis column during the determination of the analysis condition, and
the supply period determiner includes:
a peak period detector that detects a period in which a peak of a component in the sample appears with respect to a point in time at which the sample is introduced into the mobile phase as a peak appearance period based on the chromatogram generated by the generator during the determination of the analysis condition,
a time calculator that calculates a moving time in which the sample moves from the junction to the fluorescence detector based on a total flow rate of the mobile phase, the sample and the fluorescent reaction liquid that are supplied from the junction to the fluorescence detector and a volume of a flow path from the junction to the fluorescence detector during the determination of the analysis condition, and
a period calculator that calculates a period including a period starting earlier than the peak appearance period detected by the peak period detector the moving time calculated by the time calculator as the supply period during the determination of the analysis condition.