Patent ID: 11878986
Assignee: NATIONAL HEALTH RESEARCH INSTITUTES
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A compound of Formula (I):, in which
each of A1, A2, A3, A4, A5, and A6, independently, is a C1-C6 bivalent aliphatic radical;

B1 is a bond, C1-C6 bivalent aliphatic radical, a C1-C6 bivalent heteroaliphatic radical, or CHC(O)R1, in which R1 is a C1-C6 monovalent aliphatic radical, a C1-C6 monovalent heteroaliphatic radical, a monovalent aryl radical, a monovalent heteroaryl radical, a C1-C14 monovalent aralkyl radical, or a C1-C14 monovalent heteroaralkyl radical;, B2 is a bond, ethylene, phenylene, L1 is a bond, NR3, NR3C(O), or NR3CR4R5, each of R3, R4, and R5, independently, being H, a C1-C6 monovalent aliphatic radical, a C1-C6 monovalent heteroaliphatic radical, a monovalent aryl radical, a monovalent heteroaryl radical, a C1-C14 monovalent aralkyl radical, a C1-C14 monovalent heteroaralkyl radical, or C(O)R′, in which R′ is a C1-C6 monovalent aliphatic radical, a C1-C6 monovalent heteroaliphatic radical, a monovalent aryl radical, a monovalent heteroaryl radical, a C1-C14 monovalent aralkyl radical, or a C1-C14 monovalent heteroaralkyl radical;
L2 is, each of W1, W2, W3, and W4, independently, is N or CR5′, R5′ being H, NHC(O)R9, or NHC(O)NHR9, in which R9 is a C1-C6 monovalent aliphatic radical, a C1-C6 monovalent heteroaliphatic radical, a monovalent aryl radical, a monovalent heteroaryl radical, a C1-C14 monovalent aralkyl radical, or a C1-C14 monovalent heteroaralkyl radical;
X is a bond or O;
Y is a phenyl ring;
each of V1 and V2, independently, is an aryl ring or a heteroaryl ring; and
Z is an anticancer therapeutic moiety;
wherein each of the aliphatic radical, the heteroaliphatic radical, the aralkyl radical, and the heteroaralkyl radical is unsubstituted or substituted with halo, cyano, amino, hydroxyl, nitro, sulfhydryl, C1-C6 alkoxy, C1-C6 alkylamino, C1-C12 dialkylamino, or C1-C6 haloalkyl; and each of the phenyl ring, the aryl radical, and the heteroaryl radical is unsubstituted or substituted with halo, cyano, amino, hydroxyl, nitro, sulfhydryl, a C1-C6 aliphatic radical, a C1-C6 heteroaliphatic radical, or a haloaliphatic radical.