Patent ID: 11857646
Assignee: LANTHEUS MEDICAL IMAGING, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 0:
1. A method for preparing a phospholipid suspension useful for preparing lipid-encapsulated gas microspheres comprising
forming a phospholipid solution that comprises (a) a DPPA, DPPC, and MPEG5000-DPPE phospholipid blend and propylene glycol, and (b) calcium and/or magnesium at a combined concentration of less than 0.7 ppm, wherein the phospholipid blend is formed in the presence of one or two but not all three of methanol, toluene and methyl t-butyl ether (MTBE), and
combining the phospholipid solution with an aqueous solution to form a phospholipid suspension.