Patent ID: 11939600
Assignee: ARCTURUS THERAPEUTICS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 1:
2. The polynucleotide of claim 1, wherein the chemically-modified nucleotides are selected from 5-hydroxycytidine, 5-methylcytidine, 5-hydroxymethylcytidine, 5-carboxycytidine, 5-formylcytidine, 5-methoxycytidine, 5-propynylcytidine, 2-thiocytidine;
5-hydroxyuridine, 5-methyluridine, 5,6-dihydro-5-methyluridine, 2′-O-methyluridine, 2′-O-methyl-5-methyluridine, 2′-fluoro-2′-deoxyuridine, 2′-amino-2′-deoxyuridine, 2′-azido-2′-deoxyuridine, 4-thiouridine, 5-hydroxymethyluridine, 5-carboxyuridine, 5-carboxymethylesteruridine, 5-formyluridine, 5-methoxyuridine, 5-propynyluridine, 5-bromouridine, 5-iodouridine, 5-fluorouridine;
pseudouridine, 2′-O-methyl-pseudouridine, N1-hydroxypseudouridine, N1-methyl-pseudouridine, 2′-O-methyl-M-methylpseudouridine, N1-ethylpseudouridine, N1-hydroxymethylpseudouridine, Arauridine;
N6-methyladenosine, 2-aminoadenosine, 3-methyladenosine, 7-deazaadenosine, 8-oxoadenosine, inosine;
thienoguanosine, 7-deazaguanosine, 8-oxoguanosine, and 6-O-methylguanosine.