Patent ID: 11951167
Assignee: GEORGETOWN UNIVERSITY
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 0:
1. A method of treating a brain cancer in a patient, comprising:
administering via intravenous administration to the patient a targeted temozolomide cationic liposome complex, wherein the targeted temozolomide cationic liposome complex comprises:
(a) a cationic liposome comprising 1,2-dioleoyl-3-trimethylammonium propane (DOTAP) and 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE);
(b) temozolomide; and
(c) an anti-transferrin receptor single chain Fv (TfRscFv) directly complexed with, but not chemically conjugated to, the cationic liposome;

delivering the targeted temozolomide cationic liposome complex across the blood-brain barrier of the patient;
delivering the temozolomide to the brain cancer; and
inducing growth inhibition and/or regression of the brain cancer.