Patent ID: 11866483
Assignee: KANONCURE, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A method of producing a composition having high fibrosis inhibitory effect comprising the steps of:
i) culturing bone marrow mononuclear cells or mesenchymal stem cells in a culture medium containing IC-2 or an analogous compound thereof for at least 9 days, characterized in that the concentration of IC-2 or the analogous compound thereof is maintained throughout the cultivation;
ii) collecting cultured cells, secreted products of the cells or both from the culture obtained in the step i); and
iii) recovering proteins from the cultured cells, the secreted products of the cells or the both collected in the step ii)
wherein said composition comprises MMP-1, MMP-14, MMP-2, MMP-13, and thioredoxin (TRX).