Patent ID: 11878989
Assignee: SHANGHAI FOREFRONT PHARMA CO., LTD.
Field: Organic fine chemistry (Chemistry)
Classification: CPC C  Y | IPC C

Claim 4:
5. The method for preparing the L-erythro biopterin compound according to claim 1, wherein when the alkene in the compound represented by formula (II) is of a cis structure and its structural formula is represented by formula (IIa), the steps for preparing L-erythro biopterin compound represented by formula (I) from the compound represented by formula (IIa) are as follows:
the compound represented by formula (IIa) undergoes a dihydroxylation reaction to obtain the compound to be separated which is composed of the compounds represented by formula (IVa) and formula (IVa′);
the compound to be separated is separated by chiral separation reagent set to obtain the compound represented by formula (IVa-1);
the compound represented by formula (IVa-1) undergoes a cyclization reaction with, and/or the salt of, followed by a hydrolysis reaction to obtain the L-erythro biopterin compound represented by formula (I);
among them, the chiral separation reagent set includes the first reagent and the second reagent, the first reagent is boric acid ester or boric acid;
the second reagent is chiral amino alcohol;, , W, Z, Y, R1, R2, R3, R4, R5 and R6 are as defined in claim 1;
E is halogen, C1-4 alkoxy, C1-4 alkyl sulphanyl or —NH2;,