Patent ID: 11912744
Assignee: ANTIBIOTIC ALTERNATIVES LLC
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A  Y | IPC A  C

Claim 15:
16. A method for treating inflammatory or hyperproliferative oral lesions in a subject comprising:
topically applying to an oral mucosal squamous epithelial cell of the inflamed or the hyperproliferative oral lesion a composition comprising: (i) at least one in vitro transcribed isolated mRNA that comprises a synthetic 5′ cap and that encodes at least one polypeptide involved in suppressing cell proliferation wherein the at least one polypeptide comprises a polypeptide selected from the group consisting of calprotectin, S100A8, and S100A9, and (ii) a pharmaceutically acceptable in vivo delivery vehicle formulated for topical application, whereby the in vitro transcribed isolated mRNA transfected in vivo expresses the polypeptide in the cell in an amount effective to treat the inflammatory or the hyperproliferative oral lesion and the composition prevents carcinogenesis of the inflammatory or the hyperproliferative oral lesion or treats the inflammatory or the hyperproliferative oral lesion that is cancerous.