Patent ID: 11897914
Assignee: HONGENE BIOTECH CORPORATION
Field: Organic fine chemistry (Chemistry)
Classification: CPC C | IPC C

Claim 21:
22. A method of deprotecting an oligonucleotide or polynucleotide comprising at least one 2′ protected nucleotide residue comprising the structure of Formula (II):, , wherein
X is O or S;
R4 is H, unsubstituted C1-C6 alkyl or substituted C1-C6 alkyl;
B is a natural nucleobase, a modified natural nucleobase, or an unnatural nucleobase; and
RHet is optionally substituted 5-10 membered heteroaryl or optionally substituted 5-10 membered heterocyclyl;
the method comprising:
contacting the oligonucleotide or polynucleotide with a composition comprising an amine or ammonia to deprotect the 2′ protected nucleotide residue.