Patent ID: 11931414
Assignee: SEAGEN INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 10:
11. The Ligand-Drug Conjugate compound of claim 10, wherein W—Y is replaced by the Glucuronide Unit of formula —Y(W′)— for which —Y(W′)-D+ has the structure of:, or a salt thereof, wherein
the wavy line indicates the site of covalent attachment to the remainder of the Ligand Drug Conjugate compound structure;
one of R8 and R9 is hydrogen or C1-C6 alkyl and the other is hydrogen;
R′ is hydrogen, —NO2, or an electron withdrawing group;
R45 is —CH2OH or —CO2H; and
V and Z3 are ═C(R24)—, wherein one of R24 is selected from the group consisting of hydrogen and an electron withdrawing group and the other is hydrogen; and
J′ is —NH—,
wherein —O′— represents the oxygen atom of the O-glycosidic bond cleavable by the glycosidase,
or
wherein W is the Peptide Cleavable Unit for which —Y-D+ has the structure of:, or a salt thereof, wherein
the wavy line indicates the site of covalent attachment to the remainder of the Ligand Drug Conjugate compound structure,
one of R8 and R9 is hydrogen or C1-C6 alkyl and the other is hydrogen;
R′ is hydrogen, —OC1-C6 alkyl, or an electron donating group; and
V, Z1 and Z2 are ═C(R24)—, wherein each of R24 is hydrogen; and
J is —NH—.