Patent ID: 11858912
Assignee: HOFFMANN-LA ROCHE, INC.
Field: Organic fine chemistry (Chemistry)
Classification: CPC C  A  Y | IPC A  C

Claim 10:
11. The compound of formula (I) according to claim 1, or a pharmaceutically acceptable salt thereof, wherein:
X is C—R5;
R1 and R2, taken together with the nitrogen atom to which they are attached, form, R3, R4, R5 and RE are each independently halogen;
R6 is selected from the group consisting of hydrogen, C1-C6-alkyl, and, R7 is selected from the group consisting of hydrogen, C1-C6-alkoxy-C1-C6-alkyl-, and, R8 is selected from the group consisting of hydrogen, halogen, C1-C6-alkyl, and halo-C1-C6-alkyl;
R9, R10, RA4, RA5, and RB2 are hydrogen;
RA1 is (RA6)3N+—C1-C6-alkyl-C(O)— or, RA1 is selected from the group consisting of hydroxy, C1-C6-alkyl, carbamoyl-C1-C6-alkyl, and, RA2 is selected from the group consisting of C1-C6-alkyl, carboxy-C1-C6-alkyl, and carbamoyl-C1-C6-alkyl;
RA3 is hydrogen or C1-C6-alkyl;
each RA6 is independently amino-C1-C6-alkyl or carboxy-C1-C6-alkyl;
RB1 is hydrogen or halogen;
LA is carbonyl;
LB is —C1-C6-alkyldiyl- or —NH—C(O)—C1-C6-alkyldiyl-;
LE is a covalent bond;
A, A1 and A2 are each independently a 3- to 14-membered heterocyclyl;
B and D are each independently a 5- to 14-membered heteroaryl; and
E is C6-C10-aryl.