Patent ID: 11965023
Assignee: ALECTOR LLC
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A method of preventing, reducing risk, or treating a disease, disorder, or injury selected from the group consisting of Alzheimer's disease and cancer, comprising administering to an individual in need thereof a therapeutically effective amount of an anti-Siglec-5 antibody that decreases cellular levels of Siglec-5, inhibits interaction between Siglec-5 and one or more Siglec-5 ligands, or both;
wherein the cancer expresses Siglec-5 or one or more Siglec-5 ligands;
wherein the anti-Siglec-5 antibody comprises a light chain variable region comprising an HVR-L1, HVR-L2, and HVR-L3 and a heavy chain variable region comprising an HVR-H1, HVR-H2, and HVR-H3, and wherein:
a. the HVR-L1 comprises the amino acid sequence of SEQ ID NO: 3, the HVR-L2 comprises the amino acid sequence of SEQ ID NO: 13, the HVR-L3 comprises the amino acid sequence of SEQ ID NO: 20, the HVR-H1 comprises the amino acid sequence of SEQ ID NO: 27, the HVR-H2 comprises the amino acid sequence of SEQ ID NO: 35, and the HVR-H3 comprises the amino acid sequence of SEQ ID NO: 45;
b. the HVR-L1 comprises the amino acid sequence of SEQ ID NO: 4, the HVR-L2 comprises the amino acid sequence of SEQ ID NO: 14, the HVR-L3 comprises the amino acid sequence of SEQ ID NO: 21, the HVR-H1 comprises the amino acid sequence of SEQ ID NO: 27, the HVR-H2 comprises the amino acid sequence of SEQ ID NO: 36, and the HVR-H3 comprises the amino acid sequence of SEQ ID NO: 46;
c. the HVR-L1 comprises the amino acid sequence of SEQ ID NO: 5, the HVR-L2 comprises the amino acid sequence of SEQ ID NO: 14, the HVR-L3 comprises the amino acid sequence of SEQ ID NO: 22, the HVR-H1 comprises the amino acid sequence of SEQ ID NO: 28, the HVR-H2 comprises the amino acid sequence of SEQ ID NO: 37, and the HVR-H3 comprises the amino acid sequence of SEQ ID NO: 47;
d. the HVR-L1 comprises the amino acid sequence of SEQ ID NO: 6, the HVR-L2 comprises the amino acid sequence of SEQ ID NO: 14, the HVR-L3 comprises the amino acid sequence of SEQ ID NO: 23, the HVR-H1 comprises the amino acid sequence of SEQ ID NO: 27, the HVR-H2 comprises the amino acid sequence of SEQ ID NO: 38, and the HVR-H3 comprises the amino acid sequence of SEQ ID NO: 46;
e. the HVR-L1 comprises the amino acid sequence of SEQ ID NO: 4, the HVR-L2 comprises the amino acid sequence of SEQ ID NO: 14, the HVR-L3 comprises the amino acid sequence of SEQ ID NO: 24, the HVR-H1 comprises the amino acid sequence of SEQ ID NO: 29, the HVR-H2 comprises the amino acid sequence of SEQ ID NO: 39, and the HVR-H3 comprises the amino acid sequence of SEQ ID NO: 48;
f. the HVR-L1 comprises the amino acid sequence of SEQ ID NO: 7, the HVR-L2 comprises the amino acid sequence of SEQ ID NO: 15, the HVR-L3 comprises the amino acid sequence of SEQ ID NO: 25, the HVR-H1 comprises the amino acid sequence of SEQ ID NO: 30, the HVR-H2 comprises the amino acid sequence of SEQ ID NO: 40, and the HVR-H3 comprises the amino acid sequence of SEQ ID NO: 49;
g. the HVR-L1 comprises the amino acid sequence of SEQ ID NO: 7, the HVR-L2 comprises the amino acid sequence of SEQ ID NO: 15, the HVR-L3 comprises the amino acid sequence of SEQ ID NO: 25, the HVR-H1 comprises the amino acid sequence of SEQ ID NO: 31, the HVR-H2 comprises the amino acid sequence of SEQ ID NO: 41, and the HVR-H3 comprises the amino acid sequence of SEQ ID NO: 50;
h. the HVR-L1 comprises the amino acid sequence of SEQ ID NO: 8, the HVR-L2 comprises the amino acid sequence of SEQ ID NO: 16, the HVR-L3 comprises the amino acid sequence of SEQ ID NO: 25, the HVR-H1 comprises the amino acid sequence of SEQ ID NO: 32, the HVR-H2 comprises the amino acid sequence of SEQ ID NO: 42, and the HVR-H3 comprises the amino acid sequence of SEQ ID NO: 51;
i. the HVR-L1 comprises the amino acid sequence of SEQ ID NO: 9, the HVR-L2 comprises the amino acid sequence of SEQ ID NO: 16, the HVR-L3 comprises the amino acid sequence of SEQ ID NO: 25, the HVR-H1 comprises the amino acid sequence of SEQ ID NO: 31, the HVR-H2 comprises the amino acid sequence of SEQ ID NO: 41, and the HVR-H3 comprises the amino acid sequence of SEQ ID NO: 50;
j. the HVR-L1 comprises the amino acid sequence of SEQ ID NO: 10, the HVR-L2 comprises the amino acid sequence of SEQ ID NO: 16, the HVR-L3 comprises the amino acid sequence of SEQ ID NO: 25, the HVR-H1 comprises the amino acid sequence of SEQ ID NO: 33, the HVR-H2 comprises the amino acid sequence of SEQ ID NO: 40, and the HVR-H3 comprises the amino acid sequence of SEQ ID NO: 51;
k. the HVR-L1 comprises the amino acid sequence of SEQ ID NO: 11, the HVR-L2 comprises the amino acid sequence of SEQ ID NO: 14, the HVR-L3 comprises the amino acid sequence of SEQ ID NO: 22, the HVR-H1 comprises the amino acid sequence of SEQ ID NO: 28, the HVR-H2 comprises the amino acid sequence of SEQ ID NO: 37, and the HVR-H3 comprises the amino acid sequence of SEQ ID NO: 47;
l. the HVR-L1 comprises the amino acid sequence of SEQ ID NO: 12, the HVR-L2 comprises the amino acid sequence of SEQ ID NO: 17, the HVR-L3 comprises the amino acid sequence of SEQ ID NO: 26, the HVR-H1 comprises the amino acid sequence of SEQ ID NO: 34, the HVR-H2 comprises the amino acid sequence of SEQ ID NO: 43, and the HVR-H3 comprises the amino acid sequence of SEQ ID NO: 52;
m. the HVR-L1 comprises the amino acid sequence of SEQ ID NO: 11, the HVR-L2 comprises the amino acid sequence of SEQ ID NO: 18, the HVR-L3 comprises the amino acid sequence of SEQ ID NO: 24, the HVR-H1 comprises the amino acid sequence of SEQ ID NO: 27, the HVR-H2 comprises the amino acid sequence of SEQ ID NO: 44, and the HVR-H3 comprises the amino acid sequence of SEQ ID NO: 53; or
n. the HVR-L1 comprises the amino acid sequence of SEQ ID NO: 9, the HVR-L2 comprises the amino acid sequence of SEQ ID NO: 19, the HVR-L3 comprises the amino acid sequence of SEQ ID NO: 25, the HVR-H1 comprises the amino acid sequence of SEQ ID NO: 33, the HVR-H2 comprises the amino acid sequence of SEQ ID NO: 40, and the HVR-H3 comprises the amino acid sequence of SEQ ID NO: 54.