Patent ID: 11932702
Assignee: SANOFI
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A polypeptide that comprises at least three immunoglobulin single variable domains (ISVDs), wherein each of said ISVDs comprises three complementarity determining regions (CDRs), CDR1 to CDR3, respectively, and wherein:
a) a first ISVD specifically binds to the constant domain of a T cell receptor (TCR) on a T cell and comprises:
i. a CDR1 comprising the amino acid sequence of SEQ ID NO: 6;
ii. a CDR2 comprising the amino acid sequence of SEQ ID NO: 10; and
iii. a CDR3 comprising the amino acid sequence of SEQ ID NO: 14;

b) a second ISVD specifically binds to Glypican-3 (GPC3) and comprises:
iv. a CDR1 comprising the amino acid sequence of SEQ ID NO: 7;
v. a CDR2 comprising the amino acid sequence of SEQ ID NO: 11; and
vi. a CDR3 comprising the amino acid sequence of SEQ ID NO: 15; and

c) a third ISVD specifically binds to GPC3 and comprises:
vii. a CDR1 comprising the amino acid sequence of SEQ ID NO: 8;
viii. a CDR2 comprising the amino acid sequence of SEQ ID NO: 12; and
ix. a CDR3 comprising the amino acid sequence of SEQ ID NO: 16,

wherein the order of the ISVDs indicates their relative position to each other considered from the N-terminus to the C-terminus of said polypeptide.