Patent ID: 11952367
Assignee: INCYTE CORPORATION
Field: Organic fine chemistry (Chemistry)
Classification: CPC C  A | IPC C

Claim 17:
18. The method of claim 1, wherein the compound of Formula IIb is selected from:
4-[1-(4-Chlorobenzyl)-1H-pyrazol-4-yl]-2-(5-phenyl-1H-imidazol-2-yl)pyridine;
4-(1-Benzyl-1H-pyrazol-4-yl)-2-(5-phenyl-1H-imidazol-2-yl)pyridine;
2-((4-(2-(5-Phenyl-1H-imidazol-2-yl)pyridin-4-yl)-1H-pyrazol-1-yl)methyl)benzonitrile;
4-(1-(2-Chlorobenzyl)-1H-pyrazol-4-yl)-2-(5-phenyl-1H-imidazol-2-yl)pyridine;
4-(1-Methyl-1H-pyrazol-4-yl)-2-(5-phenyl-1H-imidazol-2-yl)pyridine;
4-(3-Methyl-1H-pyrazol-4-yl)-2-(5-phenyl-1H-imidazol-2-yl)pyridine;
4-(1-Ethyl-1H-pyrazol-4-yl)-2-(5-phenyl-1H-imidazol-2-yl)pyridine;
4-(3,5-Dimethyl-1H-pyrazol-4-yl)-2-(5-phenyl-1H-imidazol-2-yl)pyridine;
2-(5-Phenyl-1H-imidazol-2-yl)-4-(1-propyl-1H-pyrazol-4-yl)pyridine;
4-(1-Methyl-1H-pyrazol-5-yl)-2-(5-phenyl-1H-imidazol-2-yl)pyridine;
4-(1-Methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)-2-(5-phenyl-1H-imidazol-2-yl)pyridine;
4-(1-Methyl-1H-imidazol-2-yl)-2-(5-phenyl-1H-imidazol-2-yl)pyridine;
N-(2′-(5-Phenyl-1H-imidazol-2-yl)-3,4′-bipyridin-5-yl)acetamide;
4-(2′-(5-Phenyl-1H-imidazol-2-yl)-3,4′-bipyridin-5-yl)morpholine;
5-Methoxy-2′-(5-phenyl-1H-imidazol-2-yl)-3,4′-bipyridine;
3-((4-(2-(5-Phenyl-1H-imidazol-2-yl)pyridin-4-yl)-1H-pyrazol-1-yl)methyl)benzonitrile;
4-(1-(3-Chlorobenzyl)-1H-pyrazol-4-yl)-2-(5-phenyl-1H-imidazol-2-yl)pyridine;
2-(5-Phenyl-1H-imidazol-2-yl)-4-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridine;
4-(2-(4-(2-(5-Phenyl-1H-imidazol-2-yl)pyridin-4-yl)-1H-pyrazol-1-yl)ethyl)morpholine;
Methyl 2-((4-(2-(5-phenyl-1H-imidazol-2-yl)pyridin-4-yl)-1H-pyrazol-1-yl)methyl)benzoate;
Methyl 3-((4-(2-(5-phenyl-1H-imidazol-2-yl)pyridin-4-yl)-1H-pyrazol-1-yl)methyl)benzoate;
Methyl 4-((4-(2-(5-phenyl-1H-imidazol-2-yl)pyridin-4-yl)-1H-pyrazol-1-yl)methyl)benzoate;
2-((4-(2-(5-Phenyl-1H-imidazol-2-yl)pyridin-4-yl)-1H-pyrazol-1-yl)methyl)benzoic acid;
3-((4-(2-(5-Phenyl-1H-imidazol-2-yl)pyridin-4-yl)-1H-pyrazol-1-yl)methyl)benzoic acid;
4-((4-(2-(5-Phenyl-1H-imidazol-2-yl)pyridin-4-yl)-1H-pyrazol-1-yl)methyl)benzoic acid;
5-(4-Methylpiperazin-1-yl)-2′-(5-phenyl-1H-imidazol-2-yl)-3,4′-bipyridine;
5-(Methylsulfonyl)-2′-(5-phenyl-1H-imidazol-2-yl)-3,4′-bipyridine;
4-(2′-(5-Phenyl-1H-imidazol-2-yl)-3,4′-bipyridin-6-yl)morpholine;
4-((4-(2-(5-Phenyl-1H-imidazol-2-yl)pyridin-4-yl)-1H-pyrazol-1-yl)methyl)benzonitrile;
4-(1-(Methylsulfonyl)-1H-pyrazol-4-yl)-2-(5-phenyl-1H-imidazol-2-yl)pyridine;
4-(1-(Ethylsulfonyl)-1H-pyrazol-4-yl)-2-(5-phenyl-1H-imidazol-2-yl)pyridine;
4-(1-(Cyclopropylsulfonyl)-1H-pyrazol-4-yl)-2-(5-phenyl-1H-imidazol-2-yl)pyridine;
2-(5-Phenyl-1H-imidazol-2-yl)-4-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)pyridine;
2-(4-(2-(5-Phenyl-1H-imidazol-2-yl)pyridin-4-yl)-1H-pyrazol-1-yl)acetamide;
N,N-Dimethyl-2-(4-(2-(5-phenyl-1H-imidazol-2-yl)pyridin-4-yl)-1H-pyrazol-1-yl)acetamide;
2-(4-(2-(5-Phenyl-1H-imidazol-2-yl)pyridin-4-yl)-1H-pyrazol-1-yl)-1-(pyrrolidin-1-yl)ethanone;
1-Morpholino-2-(4-(2-(5-phenyl-1H-imidazol-2-yl)pyridin-4-yl)-1H-pyrazol-1-yl)ethanone;
3-(4-(2-(5-Phenyl-1H-imidazol-2-yl)pyridin-4-yl)-1H-pyrazol-1-yl)propanenitrile;
3-(4-(2-(5-Phenyl-1H-imidazol-2-yl)pyridin-4-yl)-1H-pyrazol-1-yl)propanamide;
4-(1-(Cyclopentylsulfonyl)-1H-pyrazol-4-yl)-2-(5-phenyl-1H-imidazol-2-yl)pyridine;
Ethyl 3-(4-(2-(5-phenyl-1H-imidazol-2-yl)pyridin-4-yl)-1H-pyrazol-1-yl)propanoate;
2-(4-(2-(5-Phenyl-1H-imidazol-2-yl)pyridin-4-yl)-1H-pyrazol-1-yl)acetonitrile;
3-(4-(2-(5-Phenyl-1H-imidazol-2-yl)pyridin-4-yl)-1H-pyrazol-1-yl)propanoic acid;
N-Methyl-3-(4-(2-(5-phenyl-1H-imidazol-2-yl)pyridin-4-yl)-1H-pyrazol-1-yl)propanamide;
N-cyclopentyl-3-(4-(2-(5-phenyl-1H-imidazol-2-yl)pyridin-4-yl)-1H-pyrazol-1-yl)propanamide;
2-(5-Phenyl-1H-imidazol-2-yl)-4-(1-(tetrahydrofuran-3-yl)-1H-pyrazol-4-yl)pyridine;
5-(5-Methoxy-3,4′-bipyridin-2′-yl)-1H-imidazol-2-amine;
N-Ethyl-5-(5-methoxy-3,4′-bipyridin-2′-yl)-1H-imidazol-2-amine;
5-(5-Methoxy-3,4′-bipyridin-2′-yl)-N-pentyl-1H-imidazol-2-amine;
N-Isobutyl-5-(5-methoxy-3,4′-bipyridin-2′-yl)-1H-imidazol-2-amine;
N-(Cyclobutylmethyl)-5-(5-methoxy-3,4′-bipyridin-2′-yl)-1H-imidazol-2-amine;
N-Butyl-5-(5-methoxy-3,4′-bipyridin-2′-yl)-4H-1,2,4-triazol-3-amine;
N-Isopropyl-5-(5-methoxy-3,4′-bipyridin-2′-yl)-4H-1,2,4-triazol-3-amine;
5-(5-Methoxy-3,4′-bipyridin-2′-yl)-N-methyl-4H-1,2,4-triazol-3-amine;
5-(5-Methoxy-3,4′-bipyridin-2′-yl)-N-phenyl-4H-1,2,4-triazol-3-amine;
5-Methoxy-2′-(5-phenyl-4H-1,2,4-triazol-3-yl)-3,4′-bipyridine;
5-Methoxy-2′-(4H-1,2,4-triazol-3-yl)-3,4′-bipyridine;
5-Methoxy-2′-(5-methyl-4H-1,2,4-triazol-3-yl)-3,4′-bipyridine;
5-Methoxy-2′-(2-phenyl-1H-imidazol-5-yl)-3,4′-bipyridine;
N-[2-(5-Methoxy-3,4′-bipyridin-2′-yl)-4-methyl-1H-imidazol-5-yl]acetamide;
2′-(4,5-Dimethyl-1H-imidazol-2-yl)-5-methoxy-3,4′-bipyridine;
5-Methoxy-2′-(5-methyl-1H-imidazol-2-yl)-3,4′-bipyridine;
2-(5-Methoxy-3,4′-bipyridin-2′-yl)-1,4,5,6-tetrahydrocyclopenta[d]imidazole;
5-Methoxy-2′-(5-(trifluoromethyl)-1H-imidazol-2-yl)-3,4′-bipyridine;
Ethyl 2-(5-methoxy-3,4′-bipyridin-2′-yl)-5-(trifluoromethyl)-1H-imidazole-4-carboxylate;
2-(5-Methoxy-3,4′-bipyridin-2′-yl)-5-(trifluoromethyl)-1H-imidazole-4-carboxylic acid;
5-Methoxy-2′-(4-methyl-5-phenyl-1H-imidazol-2-yl)-3,4′-bipyridine;
4-(2-(5-Methoxy-3,4′-bipyridin-2′-yl)-1H-imidazol-5-yl)-N,N-dimethylbenzenesulfonamide;
2′-(5-Isopropyl-1H-imidazol-2-yl)-5-methoxy-3,4′-bipyridine;
2′-(5-Ethyl-1H-imidazol-2-yl)-5-methoxy-3,4′-bipyridine;
2′-(5-Cyclopropyl-1H-imidazol-2-yl)-5-methoxy-3,4′-bipyridine;
5-Methoxy-2′-(5-(pyridin-2-yl)-1H-imidazol-2-yl)-3,4′-bipyridine;
2′-(5-tert-Butyl-1H-imidazol-2-yl)-5-methoxy-3,4′-bipyridine;
2′-(5-Methyl-1H-imidazol-2-yl)-5-morpholin-4-yl-3,4′-bipyridine;
4-(2′-(4,5-Dimethyl-1H-imidazol-2-yl)-3,4′-bipyridin-5-yl)morpholine;
4-(2′-(5-(Trifluoromethyl)-1H-imidazol-2-yl)-3,4′-bipyridin-5-yl)morpholine;
4-(2′-(5-Ethyl-1H-imidazol-2-yl)-3,4′-bipyridin-5-yl)morpholine;
4-(2′-(5-Isopropyl-1H-imidazol-2-yl)-3,4′-bipyridin-5-yl)morpholine;
4-(2′-(5-Cyclopropyl-1H-imidazol-2-yl)-3,4′-bipyridin-5-yl)morpholine;
4-(2′-(5-Cyclobutyl-1H-imidazol-2-yl)-3,4′-bipyridin-5-yl)morpholine;
4-(2′-(5-Cyclopropyl-4-methyl-1H-imidazol-2-yl)-3,4′-bipyridin-5-yl)morpholine;
4-(2′-(5-Ethyl-4-methyl-1H-imidazol-2-yl)-3,4′-bipyridin-5-yl)morpholine;
2′-(5-Cyclohexyl-1H-imidazol-2-yl)-5-(methylsulfonyl)-3,4′-bipyridine;
2′-(5-Methyl-1H-imidazol-2-yl)-5-(methylsulfonyl)-3,4′-bipyridine;
2′-(4,5-Dimethyl-1H-imidazol-2-yl)-5-(methylsulfonyl)-3,4′-bipyridine;
5-(Methylsulfonyl)-2′-(5-(trifluoromethyl)-1H-imidazol-2-yl)-3,4′-bipyridine;
2′-(5-Ethyl-1H-imidazol-2-yl)-5-(methylsulfonyl)-3,4′-bipyridine;
2′-(5-Isopropyl-1H-imidazol-2-yl)-5-(methylsulfonyl)-3,4′-bipyridine;
2′-(5-Cyclopropyl-1H-imidazol-2-yl)-5-(methylsulfonyl)-3,4′-bipyridine;
2′-(5-Cyclobutyl-1H-imidazol-2-yl)-5-(methylsulfonyl)-3,4′-bipyridine;
2′-(5-Cyclopentyl-1H-imidazol-2-yl)-5-(methylsulfonyl)-3,4′-bipyridine;
2′-(5-Benzyl-1H-imidazol-2-yl)-5-(methylsulfonyl)-3,4′-bipyridine;
2′-(5-Cyclopropyl-4-methyl-1H-imidazol-2-yl)-5-(methylsulfonyl)-3,4′-bipyridine;
2′-(5-Ethyl-4-methyl-1H-imidazol-2-yl)-5-(methylsulfonyl)-3,4′-bipyridine;
5-(Methylsulfonyl)-2′-(5-(pyridin-2-yl)-1H-imidazol-2-yl)-3,4′-bipyridine;
5-Methyl-2-(5-(methylsulfonyl)-3,4′-bipyridin-2′-yl)-1H-imidazole-4-carboxylic acid;
4-Cyclohexyl-2-[5-(methylsulfonyl)-3,4′-bipyridin-2′-yl]-1H-imidazol-5-amine;
2′-[4-(Difluoromethyl)-5-methyl-1H-imidazol-2-yl]-5-(methylsulfonyl)-3,4′-bipyridine;
[5-Methyl-2-(5-morpholin-4-yl-3,4′-bipyridin-2′-yl)-1H-imidazol-4-yl]methanol;
2-[5-Methyl-2-(5-morpholin-4-yl-3,4′-bipyridin-2′-yl)-1H-imidazol-4-yl]ethanol;
1-[5-Methyl-2-(5-morpholin-4-yl-3,4′-bipyridin-2′-yl)-1H-imidazol-4-yl]ethanol;
Methyl 5-methyl-2-(5-morpholin-4-yl-3,4′-bipyridin-2′-yl)-1H-imidazole-4-carboxylate;
tert-Butyl [2′-(5-phenyl-1H-imidazol-2-yl)-3,4′-bipyridin-5-yl]carbamate;
2′-(5-Phenyl-1H-imidazol-2-yl)-3,4′-bipyridin-5-amine;
tert-Butyl [2′-(4,5-dimethyl-1H-imidazol-2-yl)-3,4′-bipyridin-5-yl]carbamate;
2′-(4,5-Dimethyl-1H-imidazol-2-yl)-3,4′-bipyridin-5-amine;
N-[2′-(5-Phenyl-1H-imidazol-2-yl)-3,4′-bipyridin-5-yl]ethanesulfonamide;
2-Methoxy-N-[2′-(5-phenyl-1H-imidazol-2-yl)-3,4′-bipyridin-5-yl]acetamide;
N-(2′-(5-Phenyl-1H-imidazol-2-yl)-3,4′-bipyridin-5-yl)benzamide;
2-Chloro-N-(2′-(5-phenyl-1H-imidazol-2-yl)-3,4′-bipyridin-5-yl)benzamide;
3-Chloro-N-(2′-(5-phenyl-1H-imidazol-2-yl)-3,4′-bipyridin-5-yl)benzamide;
4-Chloro-N-(2′-(5-phenyl-1H-imidazol-2-yl)-3,4′-bipyridin-5-yl)benzamide;
3-Cyano-N-(2′-(5-phenyl-1H-imidazol-2-yl)-3,4′-bipyridin-5-yl)benzamide;
4-Cyano-N-(2′-(5-phenyl-1H-imidazol-2-yl)-3,4′-bipyridin-5-yl)benzamide;
N-(2′-(5-Phenyl-1H-imidazol-2-yl)-3,4′-bipyridin-5-yl)cyclopentanecarboxamide;
N-Ethyl-N′-[2′-(5-phenyl-1H-imidazol-2-yl)-3,4′-bipyridin-5-yl]urea;
Ethyl 2′-(5-phenyl-1H-imidazol-2-yl)-3,4′-bipyridin-5-ylcarbamate;
2′-(5-Phenyl-1H-imidazol-2-yl)-N-(tetrahydro-2H-pyran-4-ylmethyl)-3,4′-bipyridin-5-amine;
2′-(5-Phenyl-1H-imidazol-2-yl)-N-(tetrahydro-2H-pyran-4-yl)-3,4′-bipyridin-5-amine;
N-(1-Methylpiperidin-4-yl)-2′-(5-phenyl-1H-imidazol-2-yl)-3,4′-bipyridin-5-amine;
N-((1-Methylpiperidin-4-yl)methyl)-2′-(5-phenyl-1H-imidazol-2-yl)-3,4′-bipyridin-5-amine;
2′-(4,5-Dimethyl-1H-imidazol-2-yl)-N-(tetrahydro-2H-pyran-4-ylmethyl)-3,4′-bipyridin-5-amine;
(S)-(2′-(4,5-Dimethyl-1H-imidazol-2-yl)-3,4′-bipyridin-5-yl)(3-hydroxypyrrolidin-1-yl)methanone;
(2′-(4,5-Dimethyl-1H-imidazol-2-yl)-3,4′-bipyridin-5-yl)(4-methylpiperazin-1-yl)methanone;
(2′-(4,5-Dimethyl-1H-imidazol-2-yl)-3,4′-bipyridin-5-yl)(morpholino)methanone;
2′-(4,5-Dimethyl-1H-imidazol-2-yl)-N-(3-(dimethylamino)propyl)-3,4′-bipyridine-5-carboxamide;
4-(2′-(4,5-Dimethyl-1H-imidazol-2-yl)-3,4′-bipyridine-5-carbonyl)piperazine-1-carboxamide;
(2′-(4,5-Dimethyl-1H-imidazol-2-yl)-3,4′-bipyridin-5-yl)(pyrrolidin-1-yl)methanone;
(2′-(4,5-Dimethyl-1H-imidazol-2-yl)-3,4′-bipyridin-5-yl)(3-hydroxyazetidin-1-yl)methanone;
1-(2′-(4,5-Dimethyl-1H-imidazol-2-yl)-3,4′-bipyridine-5-carbonyl)azetidine-3-carbonitrile;
(2′-(4,5-Dimethyl-1H-imidazol-2-yl)-3,4′-bipyridin-5-yl)(3-hydroxypiperidin-1-yl)methanone;
(R)-(2′-(4,5-Dimethyl-1H-imidazol-2-yl)-3,4′-bipyridin-5-yl)(3-fluoropyrrolidin-1-yl)methanone;
(2′-(4,5-Dimethyl-1H-imidazol-2-yl)-3,4′-bipyridin-5-yl)(3-oxa-9-azaspiro[5.5]undecan-9-yl)methanone;
2′-(4,5-Dimethyl-1H-imidazol-2-yl)-N-isopropyl-3,4′-bipyridine-5-carboxamide;
(2′-(4,5-Dimethyl-1H-imidazol-2-yl)-3,4′-bipyridin-5-yl)(4-(1-methylpiperidin-4-yl)piperazin-1-yl)methanone;
1-(4-(2′-(4,5-Dimethyl-1H-imidazol-2-yl)-3,4′-bipyridine-5-carbonyl)piperazin-1-yl)ethanone;
2′-(4,5-Dimethyl-1H-imidazol-2-yl)-N-(tetrahydro-2H-pyran-4-yl)-3,4′-bipyridine-5-carboxamide;
(R)-(2′-(4,5-Dimethyl-1H-imidazol-2-yl)-3,4′-bipyridin-5-yl)(3-(dimethylamino)pyrrolidin-1-yl)methanone;
2′-(4,5-Dimethyl-1H-imidazol-2-yl)-N-((tetrahydro-2H-pyran-4-yl)methyl)-3,4′-bipyridine-5-carboxamide;
(R)-(2′-(4,5-Dimethyl-1H-imidazol-2-yl)-3,4′-bipyridin-5-yl)(3-hydroxypyrrolidin-1-yl)methanone;
2′-(4,5-Dimethyl-1H-imidazol-2-yl)-N-(2-(tetrahydro-2H-pyran-4-yl)ethyl)-3,4′-bipyridine-5-carboxamide;
(2′-(4,5-Dimethyl-1H-imidazol-2-yl)-3,4′-bipyridin-5-yl)(2-oxa-7-azaspiro[3.5]nonan-7-yl)methanone;
2′-(4,5-Dimethyl-1H-imidazol-2-yl)-N-(2-methoxyethyl)-3,4′-bipyridine-5-carboxamide;
2′-(4,5-Dimethyl-1H-imidazol-2-yl)-N-((tetrahydrofuran-2-yl)methyl)-3,4′-bipyridine-5-carboxamide;
1-(2′-(4,5-Dimethyl-1H-imidazol-2-yl)-3,4′-bipyridine-5-carbonyl)pyrrolidin-3-one;
(2′-(4,5-Dimethyl-1H-imidazol-2-yl)-3,4′-bipyridin-5-yl)(3-(2-hydroxyethyl)pyrrolidin-1-yl)methanone;
(2′-(4,5-Dimethyl-1H-imidazol-2-yl)-3,4′-bipyridin-5-yl)(3-(pyridin-2-yl)pyrrolidin-1-yl)methanone;
2-(2′-(4,5-Dimethyl-1H-imidazol-2-yl)-3,4′-bipyridine-5-carbonyl)-6-methyl-2,6-diazaspiro[3.4]octan-5-one;
((3R,4R)-1-{[2′-(4,5-Dimethyl-1H-imidazol-2-yl)-3,4′-bipyridin-5-yl]carbonyl}-4-methylpyrrolidin-3-yl)methanol;
5-[(3,3-Difluoropyrrolidin-1-yl)carbonyl]-2′-(4,5-dimethyl-1H-imidazol-2-yl)-3,4′-bipyridine;
2′-(4,5-Dimethyl-1H-imidazol-2-yl)-5-[(3-methoxypyrrolidin-1-yl)carbonyl]-3,4′-bipyridine;
Methyl 1-{[2′-(4,5-dimethyl-1H-imidazol-2-yl)-3,4′-bipyridin-5-yl]carbonyl}pyrrolidine-3-carboxylate;
2′-(4,5-Dimethyl-1H-imidazol-2-yl)-N-[(3R)-tetrahydrofuran-3-yl]-3,4′-bipyridine-5-carboxamide;
1-{[2′-(4,5-Dimethyl-1H-imidazol-2-yl)-3,4′-bipyridin-5-yl]carbonyl}piperidin-4-ol;
2′-(4,5-Dimethyl-1H-imidazol-2-yl)-5-{[3-(trifluoromethyl)pyrrolidin-1-yl]carbonyl}-3,4′-bipyridine;
5-(7-Azabicyclo[2.2.1]hept-7-ylcarbonyl)-2′-(4,5-dimethyl-1H-imidazol-2-yl)-3,4′-bipyridine;
1-{[2′-(4,5-Dimethyl-1H-imidazol-2-yl)-3,4′-bipyridin-5-yl]carbonyl}-3-methylpyrrolidin-3-ol;
2′-(4,5-Dimethyl-1H-imidazol-2-yl)-5-[(3-phenylpyrrolidin-1-yl)carbonyl]-3,4′-bipyridine;
2′-(4,5-Dimethyl-1H-imidazol-2-yl)-5-[(3-pyridin-4-ylpyrrolidin-1-yl)carbonyl]-3,4′-bipyridine;
1-{[2′-(4,5-Dimethyl-1H-imidazol-2-yl)-3,4′-bipyridin-5-yl]carbonyl}pyrrolidine-3-carbonitrile;
2′-(4,5-Dimethyl-1H-imidazol-2-yl)-5-{[2-(trifluoromethyl)azetidin-1-yl]carbonyl}-3,4′-bipyridine;
5-[(3,3-Dimethylazetidin-1-yl)carbonyl]-2′-(4,5-dimethyl-1H-imidazol-2-yl)-3,4′-bipyridine;
2′-(4,5-Dimethyl-1H-imidazol-2-yl)-5-[(4-phenylpiperidin-1-yl)carbonyl]-3,4′-bipyridine;
2′-(4,5-Dimethyl-1H-imidazol-2-yl)-5-[(4aR,8aS)-octahydroisoquinolin-2(1H)-ylcarbonyl]-3,4′-bipyridine;
2′-(4,5-Dimethyl-1H-imidazol-2-yl)-5-[(3-phenylpiperidin-1-yl)carbonyl]-3,4′-bipyridine;
5-[(4-Benzylpiperidin-1-yl)carbonyl]-2′-(4,5-dimethyl-1H-imidazol-2-yl)-3,4′-bipyridine;
2′-(4,5-Dimethyl-1H-imidazol-2-yl)-5-[(2-methylpiperidin-1-yl)carbonyl]-3,4′-bipyridine;
5-(Azetidin-1-ylcarbonyl)-2′-(4,5-dimethyl-1H-imidazol-2-yl)-3,4′-bipyridine;
N-Benzyl-2′-(4,5-dimethyl-1H-imidazol-2-yl)-3,4′-bipyridine-5-carboxamide;
N-Benzyl-2′-(4,5-dimethyl-1H-imidazol-2-yl)-N-methyl-3,4′-bipyridine-5-carboxamide;
2′-(4,5-Dimethyl-1H-imidazol-2-yl)-N-methyl-N-phenyl-3,4′-bipyridine-5-carboxamide;
2′-(4,5-Dimethyl-1H-imidazol-2-yl)-N-[(1S)-1-phenylethyl]-3,4′-bipyridine-5-carboxamide;
4-Benzyl-1-{[2′-(4,5-dimethyl-1H-imidazol-2-yl)-3,4′-bipyridin-5-yl]carbonyl}piperidin-4-ol;
2′-(4,5-Dimethyl-1H-imidazol-2-yl)-5-[(3-pyrazin-2-ylpyrrolidin-1-yl)carbonyl]-3,4′-bipyridine;
2′-(4,5-Dimethyl-1H-imidazol-2-yl)-N-ethyl-N-methyl-3,4′-bipyridine-5-carboxamide;
2′-(4,5-Dimethyl-1H-imidazol-2-yl)-5-[(3-methoxyazetidin-1-yl)carbonyl]-3,4′-bipyridine;
2′-(4,5-Dimethyl-1H-imidazol-2-yl)-5-[(4-methyl-1,4-diazepan-1-yl)carbonyl]-3,4′-bipyridine;
2′-(4,5-Dimethyl-1H-imidazol-2-yl)-N-(2-hydroxyethyl)-N-methyl-3,4′-bipyridine-5-carboxamide;
N-(Cyclopropylmethyl)-2′-(4,5-dimethyl-1H-imidazol-2-yl)-3,4′-bipyridine-5-carboxamide;
N-(Cyanomethyl)-2′-(4,5-dimethyl-1H-imidazol-2-yl)-N-methyl-3,4′-bipyridine-5-carboxamide;
2′-(4,5-Dimethyl-1H-imidazol-2-yl)-N-(2-methoxyethyl)-N-methyl-3,4′-bipyridine-5-carboxamide;
2′-(4,5-Dimethyl-1H-imidazol-2-yl)-N-{[1-(hydroxymethyl)cyclopropyl]methyl}-N-methyl-3,4′-bipyridine-5-carboxamide;
N-(Cyclobutylmethyl)-2′-(4,5-dimethyl-1H-imidazol-2-yl)-3,4′-bipyridine-5-carboxamide;
N-(Cyclopentylmethyl)-2′-(4,5-dimethyl-1H-imidazol-2-yl)-3,4′-bipyridine-5-carboxamide;
N-(tert-Butyl)-2′-(4,5-dimethyl-1H-imidazol-2-yl)-3,4′-bipyridine-5-carboxamide;
2′-(4,5-Dimethyl-1H-imidazol-2-yl)-N-(3-hydroxypropyl)-N-methyl-3,4′-bipyridine-5-carboxamide;
2′-(4,5-Dimethyl-1H-imidazol-2-yl)-N-methyl-N-propyl-3,4′-bipyridine-5-carboxamide;
2′-(4,5-Dimethyl-1H-imidazol-2-yl)-5-[(3-ethylpyrrolidin-1-yl)carbonyl]-3,4′-bipyridine;
5-(5-Azaspiro[2.4]hept-5-ylcarbonyl)-2′-(4,5-dimethyl-1H-imidazol-2-yl)-3,4′-bipyridine;
2′-(4,5-Dimethyl-1H-imidazol-2-yl)-1-(phenylsulfonyl)-1,2,5,6-tetrahydro-3,4′-bipyridine;
2-(4,5-Dimethyl-1H-imidazol-2-yl)-4-[1-(phenylsulfonyl)piperidin-3-yl]pyridine;
1-(4-(2-(4,5-Dimethyl-1H-imidazol-2-yl)pyridin-4-yl)-5,6-dihydropyridin-1(2H)-yl)ethanone;
1-(3-(2-(4,5-Dimethyl-1H-imidazol-2-yl)pyridin-4-yl)-5,6-dihydropyridin-1(2H)-yl)ethanone;
2-(4,5-Dimethyl-1H-imidazol-2-yl)-4-(1-(methylsulfonyl)-1,2,5,6-tetrahydropyridin-3-yl)pyridine;
4-(1-(4-Chlorophenylsulfonyl)-1,2,5,6-tetrahydropyridin-3-yl)-2-(4,5-dimethyl-1H-imidazol-2-yl)pyridine;
(3-(2-(4,5-Dimethyl-1H-imidazol-2-yl)pyridin-4-yl)-5,6-dihydropyridin-1(2H)-yl)(phenyl)methanone;
4-(1-Benzyl-1,2,5,6-tetrahydropyridin-3-yl)-2-(4,5-dimethyl-1H-imidazol-2-yl)pyridine;
4-(1-(4-Chlorobenzyl)-1,2,5,6-tetrahydropyridin-3-yl)-2-(4,5-dimethyl-1H-imidazol-2-yl)pyridine;
2-(4,5-Dimethyl-1H-imidazol-2-yl)-4-(1-((tetrahydro-2H-pyran-4-yl)methyl)-1,2,5,6-tetrahydropyridin-3-yl)pyridine;
1-(3-(2-(4,5-Dimethyl-1H-imidazol-2-yl)pyridin-4-yl)-2,5-dihydro-1H-pyrrol-1-yl)ethanone;
2-(4,5-Dimethyl-1H-imidazol-2-yl)-4-(1-(methylsulfonyl)-2,5-dihydro-1H-pyrrol-3-yl)pyridine;
4-(1-Benzyl-2,5-dihydro-1H-pyrrol-3-yl)-2-(4,5-dimethyl-1H-imidazol-2-yl)pyridine;
4-(1-(4-Chlorobenzyl)-2,5-dihydro-1H-pyrrol-3-yl)-2-(4,5-dimethyl-1H-imidazol-2-yl)pyridine;
2-(4,5-Dimethyl-1H-imidazol-2-yl)-4-(1-((tetrahydro-2H-pyran-4-yl)methyl)-2,5-dihydro-1H-pyrrol-3-yl)pyridine;
(3R)-1-[2′-(4,5-Dimethyl-1H-imidazol-2-yl)-3,4′-bipyridin-5-yl]pyrrolidin-3-ol;
(3S)-1-[2′-(4,5-Dimethyl-1H-imidazol-2-yl)-3,4′-bipyridin-5-yl]pyrrolidin-3-ol;
2′-(4,5-Dimethyl-1H-imidazol-2-yl)-N-phenyl-3,4′-bipyridin-5-amine;
5-Chloro-2′-(4,5-dimethyl-1H-imidazol-2-yl)-3,4′-bipyridine;
tert-Butyl 3-[2′-(4,5-dimethyl-1H-imidazol-2-yl)-3,4′-bipyridin-5-yl]-2,5-dihydro-1H-pyrrole-1-carboxylate;
5-(2,5-Dihydro-1H-pyrrol-3-yl)-2′-(4,5-dimethyl-1H-imidazol-2-yl)-3,4′-bipyridine;
2′-(4,5-Dimethyl-1H-imidazol-2-yl)-5-[1-(methylsulfonyl)-2,5-dihydro-1H-pyrrol-3-yl]-3,4′-bipyridine;
1-(3-(2′-(4,5-Dimethyl-1H-imidazol-2-yl)-3,4′-bipyridin-5-yl)-2,5-dihydro-1H-pyrrol-1-yl)ethanone;
Methyl 3-(2′-(4,5-dimethyl-1H-imidazol-2-yl)-3,4′-bipyridin-5-yl)-2,5-dihydro-1H-pyrrole-1-carboxylate;
2′-(4,5-Dimethyl-1H-imidazol-2-yl)-5-[1-(methylsulfonyl)pyrrolidin-3-yl]-3,4′-bipyridine;
Ethyl 5-methyl-2-[5-(methylsulfonyl)-3,4′-bipyridin-2′-yl]-1H-imidazole-4-carboxylate;
5-Methyl-2-[5-(methylsulfonyl)-3,4′-bipyridin-2′-yl]-1H-imidazole-4-carboxylic acid;
N-Cyclopentyl-5-methyl-2-[5-(methylsulfonyl)-3,4′-bipyridin-2′-yl]-1H-imidazole-4-carboxamide;
2′-[5-Methyl-4-(morpholin-4-ylcarbonyl)-1H-imidazol-2-yl]-5-(methylsulfonyl)-3,4′-bipyridine;
(3R)-1-({5-Methyl-2-[5-(methylsulfonyl)-3,4′-bipyridin-2′-yl]-1H-imidazol-4-yl}carbonyl)pyrrolidin-3-ol;
(3S)-1-({5-Methyl-2-[5-(methylsulfonyl)-3,4′-bipyridin-2′-yl]-1H-imidazol-4-yl}carbonyl)pyrrolidin-3-ol;
1-({5-Methyl-2-[5-(methylsulfonyl)-3,4′-bipyridin-2′-yl]-1H-imidazol-4-yl}carbonyl)azetidin-3-ol;
1-({5-Methyl-2-[5-(methylsulfonyl)-3,4′-bipyridin-2′-yl]-1H-imidazol-4-yl}carbonyl)azetidine-3-carbonitrile;
5-Methyl-2-[5-(methylsulfonyl)-3,4′-bipyridin-2′-yl]-1H-imidazole-4-carboxamide;
N,5-Dimethyl-2-[5-(methylsulfonyl)-3,4′-bipyridin-2′-yl]-1H-imidazole-4-carboxamide;
N,N,5-Trimethyl-2-[5-(methylsulfonyl)-3,4′-bipyridin-2′-yl]-1H-imidazole-4-carboxamide;
N-Ethyl-5-methyl-2-[5-(methylsulfonyl)-3,4′-bipyridin-2′-yl]-1H-imidazole-4-carboxamide;
N-Isopropyl-5-methyl-2-[5-(methylsulfonyl)-3,4′-bipyridin-2′-yl]-1H-imidazole-4-carboxamide;
5-Methyl-2-[5-(methylsulfonyl)-3,4′-bipyridin-2′-yl]-N-(tetrahydro-2H-pyran-4-yl)-1H-imidazole-4-carboxamide;
5-Methyl-2-[5-(methylsulfonyl)-3,4′-bipyridin-2′-yl]-N-[(3S)-tetrahydrofuran-3-yl]-1H-imidazole-4-carboxamide;
5-Methyl-2-[5-(methylsulfonyl)-3,4′-bipyridin-2′-yl]-N-[(3R)-tetrahydrofuran-3-yl]-1H-imidazole-4-carboxamide;
5-Methyl-2-(5-morpholin-4-yl-3,4′-bipyridin-2′-yl)-1H-imidazole-4-carboxylic acid;
N-Cyclopentyl-5-methyl-2-(5-morpholin-4-yl-3,4′-bipyridin-2′-yl)-1H-imidazole-4-carboxamide;
N-Isopropyl-N,5-dimethyl-2-(5-morpholin-4-yl-3,4′-bipyridin-2′-yl)-1H-imidazole-4-carboxamide;
N-Ethyl-N,5-dimethyl-2-(5-morpholin-4-yl-3,4′-bipyridin-2′-yl)-1H-imidazole-4-carboxamide;
N,5-Dimethyl-2-(5-morpholin-4-yl-3,4′-bipyridin-2′-yl)-N-(tetrahydrofuran-3-yl)-1H-imidazole-4-carboxamide;
2′-(5-Methyl-4-{[3-(trifluoromethyl)azetidin-1-yl]carbonyl}-1H-imidazol-2-yl)-5-morpholin-4-yl-3,4′-bipyridine;
2′-{4-[(3-Methoxyazetidin-1-yl)carbonyl]-5-methyl-1H-imidazol-2-yl}-5-morpholin-4-yl-3,4′-bipyridine;
tert-Butyl (1-{[5-methyl-2-(5-morpholin-4-yl-3,4′-bipyridin-2′-yl)-1H-imidazol-4-yl]carbonyl}azetidin-3-yl)carbamate;
N-Cyclohexyl-5-methyl-2-(5-morpholin-4-yl-3,4′-bipyridin-2′-yl)-1H-imidazole-4-carboxamide;
N-(tert-Butyl)-5-methyl-2-(5-morpholin-4-yl-3,4′-bipyridin-2′-yl)-1H-imidazole-4-carboxamide;
2′-{4-[(3,3-Dimethylazetidin-1-yl)carbonyl]-5-methyl-1H-imidazol-2-yl}-5-morpholin-4-yl-3,4′-bipyridine;
N-Isopropyl-5-methyl-2-(5-morpholin-4-yl-3,4′-bipyridin-2′-yl)-1H-imidazole-4-carboxamide;
5-Methyl-2-(5-morpholin-4-yl-3,4′-bipyridin-2′-yl)-N-(tetrahydro-2H-pyran-4-yl)-1H-imidazole-4-carboxamide;
5-Methyl-2-(5-morpholin-4-yl-3,4′-bipyridin-2′-yl)-N-[(3R)-tetrahydrofuran-3-yl]-1H-imidazole-4-carboxamide;
5-Methyl-2-(5-morpholin-4-yl-3,4′-bipyridin-2′-yl)-N-[(3S)-tetrahydrofuran-3-yl]-1H-imidazole-4-carboxamide;
N-Benzyl-5-methyl-2-(5-morpholin-4-yl-3,4′-bipyridin-2′-yl)-1H-imidazole-4-carboxamide;
5-Methyl-2-(5-morpholin-4-yl-3,4′-bipyridin-2′-yl)-N-[(1S)-1-phenylethyl]-1H-imidazole-4-carboxamide;
5-Methyl-2-(5-morpholin-4-yl-3,4′-bipyridin-2′-yl)-N-[(1R)-1-phenylethyl]-1H-imidazole-4-carboxamide;
N-[(1R)-2-Methoxy-1-phenylethyl]-5-methyl-2-(5-morpholin-4-yl-3,4′-bipyridin-2′-yl)-1H-imidazole-4-carboxamide;
N-[(1S)-2-Methoxy-1-phenylethyl]-5-methyl-2-(5-morpholin-4-yl-3,4′-bipyridin-2′-yl)-1H-imidazole-4-carboxamide;
N-[1-(3-Fluorophenyl)ethyl]-5-methyl-2-(5-morpholin-4-yl-3,4′-bipyridin-2′-yl)-1H-imidazole-4-carboxamide;
N-2-Adamantyl-5-methyl-2-(5-morpholin-4-yl-3,4′-bipyridin-2′-yl)-1H-imidazole-4-carboxamide;
N-[(3S)-1-Benzylpyrrolidin-3-yl]-5-methyl-2-(5-morpholin-4-yl-3,4′-bipyridin-2′-yl)-1H-imidazole-4-carboxamide;
N-[(3R)-1-Benzylpyrrolidin-3-yl]-5-methyl-2-(5-morpholin-4-yl-3,4′-bipyridin-2′-yl)-1H-imidazole-4-carboxamide;
5-Methyl-2-(5-morpholin-4-yl-3,4′-bipyridin-2′-yl)-N-(tetrahydro-2H-thiopyran-4-yl)-1H-imidazole-4-carboxamide;
N-(2,3-Dihydro-1H-inden-2-yl)-5-methyl-2-(5-morpholin-4-yl-3,4′-bipyridin-2′-yl)-1H-imidazole-4-carboxamide;
N-{[5-Methyl-2-(5-morpholin-4-yl-3,4′-bipyridin-2′-yl)-1H-imidazol-4-yl]methyl}tetrahydro-2H-pyran-4-amine;
N-{[5-Methyl-2-(5-morpholin-4-yl-3,4′-bipyridin-2′-yl)-1H-imidazol-4-yl]methyl}cyclopentanamine;
N-{[5-Methyl-2-(5-morpholin-4-yl-3,4′-bipyridin-2′-yl)-1H-imidazol-4-yl]methyl}propan-2-amine;
(3S)-N-{[5-Methyl-2-(5-morpholin-4-yl-3,4′-bipyridin-2′-yl)-1H-imidazol-4-yl]methyl}tetrahydrofuran-3-amine;
(3R)-N-{[5-Methyl-2-(5-morpholin-4-yl-3,4′-bipyridin-2′-yl)-1H-imidazol-4-yl]methyl}tetrahydrofuran-3-amine;
N-Methyl-1-[5-methyl-2-(5-morpholin-4-yl-3,4′-bipyridin-2′-yl)-1H-imidazol-4-yl]methanamine;
N,N-Dimethyl-1-[5-methyl-2-(5-morpholin-4-yl-3,4′-bipyridin-2′-yl)-1H-imidazol-4-yl]methanamine;
2-Methoxy-N-{[5-methyl-2-(5-morpholin-4-yl-3,4′-bipyridin-2′-yl)-1H-imidazol-4-yl]methyl}ethanamine;
3-Methoxy-N-{[5-methyl-2-(5-morpholin-4-yl-3,4′-bipyridin-2′-yl)-1H-imidazol-4-yl]methyl}propan-1-amine;
2′-[5-Methyl-4-(morpholin-4-ylmethyl)-1H-imidazol-2-yl]-5-morpholin-4-yl-3,4′-bipyridine;
2′-(4,5-Dimethyl-1H-imidazol-2-yl)-3,4′-bipyridin-5-yl]methanol;
4-(1-(4-Chlorobenzyl)-1H-pyrazol-4-yl)-2-(4,5-dimethyl-1H-imidazol-2-yl)pyridine; and
(2-{4-[1-(4-Chlorobenzyl)-1H-pyrazol-4-yl]pyridin-2-yl}-5-methyl-N-[(3S)-tetrahydrofuran-3-yl]-1H-imidazole-4-carboxamide;
or a pharmaceutically acceptable salt or tautomer of any of the aforementioned.