Patent ID: 11951476
Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
Field: Measurement (Instruments)
Classification: CPC B  G  H | IPC B  C  G  H

Claim 1:
2. A method, comprising:
applying a sample to a device,
wherein the device comprises:
a substrate;
at least two electrodes;
a microfluidic channel comprising at least one inlet and an outlet; and
at least one magnet;
wherein the at least two electrodes are disposed on the substrate,
wherein the microfluidic channel is disposed in proximity to the at least two electrodes on the substrate,
wherein the at least two electrodes are configured to generate an electric field, and
wherein the at least one magnet is configured to provide a magnetic field in at least a portion of the microfluidic channel,

wherein the sample comprises at least one cell;

incorporating at least one magnetic particle to the sample;
applying an input voltage of at least a single frequency to the at least two electrodes, generating an electric field;
passing the sample from the at least one inlet to the outlet of the microfluidic channel through the electric field;
measuring a current signal from each of the at least two electrodes, producing a pulse; and
detecting the pulse,
wherein a pulse of the at least one cell of the sample with the at least one magnetic particle comprises an amplitude, a pulse width, a rise time, a fall time, a NWDF, or combinations thereof less than that in a pulse of a cell without at least one magnetic particle.