Patent ID: 11933781
Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO
Field: Measurement (Instruments)
Classification: CPC G  A | IPC C  G

Claim 0:
1. A method of screening a test compound for induction of an unjammed-to-jammed transition (UJT) in fibrotic primary human bronchial epithelial cells (HBECs) isolated from a subject with a fibrotic lung disease, comprising
culturing the fibrotic primary HBECs at an air-liquid interface for a time sufficient to provide a differentiated pseudostratified epithelium;
contacting the cultured cells with the test compound; and
monitoring the motility of the cultured cells to identify the cultured cells as moving or stationary;
wherein stationary cultured cells indicate that the test compound induces the UJT.