Patent ID: 11866514
Assignee: GENMAB A/S
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A  G | IPC A  C  G

Claim 8:
9. A heterodimeric antibody comprising:
(a) a first chimeric, humanized, or human heavy chain comprising a hinge region comprising a Cys-Pro-Pro-Cys (SEQ ID NO: 4) sequence and a first Fc region, said first Fc region comprising a first CH3 region of human IgG4,
(b) a second chimeric, humanized, or human heavy chain comprising a hinge region comprising a Cys-Pro-Pro-Cys (SEQ ID NO: 4) sequence and a second Fc region, said second Fc region comprising a second CH3 region of human IgG4 comprising amino acid substitutions to Leu at position 405 and Lys at position 409, wherein the numbering is according to the EU Index), and
(c) two full-length light chains,
wherein the heterodimeric antibody is human IgG4 isotype except for the specified substitutions and hinge region, and
wherein the sequences of the first and second CH3 regions are different.