Patent ID: 11965002
Assignee: THE BD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 5:
6. A fusion protein comprising a non-receptor tyrosine kinase having inserted in the glycine-rich loop of the catalytic domain of the non-receptor tyrosine kinase a light-responsive construct comprising a first photoreceptive polypeptide domain and a second photoreceptive polypeptide domain, wherein said first and second photoreceptive polypeptide domains are the same:
(i) are operatively-linked via a flexible linker;
(ii) comprise
(a) amino acid residues 37-184 of SEQ ID NO:1,
(b) amino acid residues 40-186 of SEQ ID NO:1,
(c) a variant of (a) or (b) comprising one or more amino acid substitutions selected from the group consisting of Ile74Val, Ile85Val, Met135Ile, and Met165Ile, or
(d) a variant of amino acids 37-186 of SEQ ID NO:1 comprising one or more amino acid substitutions selected from the group consisting of Ile74Val, Ile85Val, Met135Ile, and Met165Ile; and

(iii) homodimerize with each other.