Patent ID: 11911406
Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C  Y | IPC A  C

Claim 21:
22. A polymer-drug conjugate comprising:
a polymer comprising a plurality of cationic functional groups selected from ammonium, amidinium, and/or guanidinium functional groups; and
an antibiotic drug linked to the cationic polymer by a pH-sensitive linker that releases the drug faster in aqueous solution at a pH value selected from a range of 4.5 to 7 compared to a pH value above 7;
wherein
the polymer comprises one or more disulfide bonds in a backbone of the polymer; and
the pH-sensitive linker is selected from the group consisting of hydrazone, 2,3-dimethyl maleic acid ester and/or amide, imine, ketal, acetal, and phenyl boronic acid and ester.