Patent ID: 11884941
Assignee: SYRACUSE UNIVERSITY
Field: Biotechnology (Chemistry)
Classification: CPC C | IPC C

Claim 0:
1. A method of synthesizing a non-naturally occurring lipoprotein, comprising the steps of:
modifying a host organism to express a Saccharomyces cerevisiae N-myristoyl transferase;
modifying the host organism to express an intrisincally disordered peptide polymer fused to a peptide substrate of the N-myristoyl transferase; and
coexpressing the N-myristoyl transferase and the intrinsically disordered peptide polymer from the host organism in the presence of an expression media having a non-natural fatty acid having the formula R—COOH, where R contains a linear chain of no more than 15 atoms of C, N, O or S, so that the intrinsically disordered peptide polymer fused to the peptide substrate is subjected to post-translational modification by the host organism to form a non-naturally occurring lipoprotein.