Patent ID: 11881311
Assignee: BIOAGE LABS, INC.
Field: Measurement (Instruments)
Classification: CPC G | IPC G

Claim 0:
1. A method for determining a survival metric for a subject, comprising:
obtaining a dataset associated with a sample from the subject comprising metabolite values for each of at least n survival, each metabolite value representing a presence of metabolites corresponding to the survival biomarker, the dataset generated for the sample using at least one survival biomarker detection assay;
accessing a default state representing a subject having normalized metabolite values for each of the n survival biomarkers, each normalized metabolite value determined based on a distribution of metabolites for the corresponding survival biomarker within a set of samples from a population of subjects;
for each of the n survival biomarkers, comparing the metabolite value in the obtained dataset associated with the sample from the subject to a corresponding normalized metabolite value in the default state to determine a relative metabolite value, wherein each relative metabolite value represents an abundance or lack of metabolites for the corresponding survival biomarker in the sample from the subject compared to the default state;
encoding the determined relative metabolite values into a vector representation;
inputting the vector representation into a survival predictor model comprising coefficients for the n survival biomarkers to generate a survival metric value representing a relative survival risk of the subject compared to the default state, wherein the survival predictor model is a machine-learning model iteratively trained using a training dataset including a set of survival biomarkers labeled to determine the coefficients of the survival predictor model, the set of survival biomarkers comprising the at least n survival biomarkers of the obtained dataset; and
providing the survival metric value.