Patent ID: 11944674
Assignee: OXFORD UNIVERSITY INNOVATION LIMITED
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  Y | IPC A

Claim 0:
1. A fusion polypeptide or a particle comprising the fusion polypeptide, wherein the fusion polypeptide comprises:
(i) 8-12 repeat units derived from the repeating region of a Type I circumsporozoite protein (CSP) of Plasmodium vivax, 
wherein the repeat units have amino acid sequences independently selected from the group consisting of:, (SEQ ID NO: 3)

GDRAAGQPA

 

(SEQ ID NO: 4)

GDRADGQPA

and

 

(SEQ ID NO: 5)

GNGAGGQAA;

(ii) 8-12 repeat units derived from the repeating region of a Type II circumsporozoite protein (CSP) of Plasmodium vivax, 
wherein the repeat units have amino acid sequences independently selected from the group consisting of:, (SEQ ID NO: 6)

ANGAGNQPG

 

(SEQ ID NO: 7)

ANGAGGQAA

 

(SEQ ID NO: 8)

ANGAGDQPG

 

(SEQ ID NO: 9)

ANGADDQPG

and

 

(SEQ ID NO: 10)

EDGAGNQPG;, and
(iii) an amino acid sequence derived from the C-terminal fragment of CSP of Plasmodium vivax; and optionally
(iv) an amino acid sequence derived from the Hepatitis B virus surface antigen.