Patent ID: 11972858
Assignee: UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
Field: Computer technology (Electrical engineering)
Classification: CPC G | IPC G

Claim 14:
15. A computerized system for characterizing cellular phenotypes, comprising:
a processing apparatus, wherein the processing apparatus includes a cellular phenotype characterizing component configured for:
receiving segmented multi-parameter cellular and sub-cellular imaging data, wherein the segmented multi-parameter cellular and sub-cellular imaging data is generated by performing cellular segmentation on the multi-parameter cellular and sub-cellular imaging data; and
performing recursive decomposition on the segmented multi-parameter cellular and subcellular imaging data to identify a plurality of computational phenotypes, wherein the recursive decomposition includes a plurality of levels of decomposition with each level of decomposition including soft/probabilistic clustering and spatial regularization, and wherein each cell in the segmented multi-parameter cellular and subcellular imaging data is probabilistically assigned to one or more of the plurality of computational phenotypes.