Patent ID: 11919972
Assignee: REGENERON PHARMACEUTICALS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  G  A | IPC A  C  G

Claim 24:
25. A method of imaging in vivo expression of a target, the method comprising:
(a) providing a cyclic peptide of claim 1, wherein SEQ is a peptide sequence having affinity for the target, and modifying the cyclic peptide to include a small-molecule single-photon-emission-computed-tomography ligand (SPECT ligand);
(b) administering the cyclic peptide of step (a) to the subject;
(c) measuring the photon emission from the SPECT ligand at a first time;
(d) measuring the photon emission from the SPECT ligand at a second time; and
(e) comparing the photon emission from the SPECT ligand at the first and second times wherein the SPECT ligand comprises a moiety selected from 111In DOTA, 90Y DOTA, 111In, 90Y, and 99mTc.