Patent ID: 11859169
Assignee: KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 0:
1. A method of promoting cell adhesion and regeneration of macrophages, the method comprising:
manufacturing a nano-ligand presenting substrate by putting a substrate, of which a surface is positively charged, in a solution including a nano-ligand for promoting cell adhesion and regeneration of macrophages, the nano-ligand for promoting cell adhesion and regeneration of macrophages comprising a core including magnetic nano-particles; and a coating layer provided to surround the core and including an integrin-specific ligand peptide, wherein the integrin-specific ligand peptide is negatively charged, the magnetic nano-particles comprise an iron oxide having a surface coupled with silica and have magnetic properties, and in the coating layer, the integrin-specific ligand peptide that specifically binds to an integrin of the macrophages is provided to surround an external surface of the core to coat the core; and
controlling cell adhesion and regenerative polarization of macrophages by treating the nano-ligand presenting substrate with a culture medium and then applying an external magnetic field.