Patent ID: 11938226
Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 0:
1. A method of inhibiting angiogenesis in a subject comprising administering to the subject a therapeutically effective amount of a composition comprising a pharmaceutically acceptable carrier and an abiotic, synthetic cross-linked polymer having affinity to vascular endothelial growth factor (VEGF), comprising:
N-isopropylacrylamide (NIPAm);
N-tert-butylacrylamide (TBAm);
N,N′-methylenebisacrylamide (Bis); and
a sulfated N-acetylglucosamine (GlcNAc), wherein the polymer comprises between 1% and 3% sulfated GlcNAc.