Patent ID: 11944619
Assignee: SRX CARDIO, LLC
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 11:
12. A method for inducing hypocholesterolemia in a mammal in need thereof comprising administering to said mammal a compound of Formula I, or a pharmaceutically acceptable salt, hydrate, solvate, or tautomeric form thereof:, wherein
R3 is selected from the group consisting of H, lower alkyl, halo, haloalkyl, hydroxyalkyl, alkoxyl, and nitrile;
R4 is selected from the group consisting of H and —OH;
R5 is selected from the group consisting of alkyl, lower alkyl, branched alkyl, aryl-substituted alkyl, cycloalkyl, hydroxyalkyl, alkoxyalkyl, haloalkyl, and an amino acid, wherein the amino acid is an L- or D-isomer of the formula —CHR6—CON—R7;
wherein i) R6 is selected from the group consisting of natural and unnatural peptide side chains; ii) R7 is selected from the group consisting of alkyl, lower alkyl, branched alkyl, cycloalkyl, and heterocycle;

X1 through X5 are selected independently from CH, CR1, CR2, and N, wherein at most one of X1 to X5 is CR1 and at most one of X1 to X5 is CR2, and wherein X1 to X5 are part of an aromatic or heteroaryl ring;
R1 and R2 are independently selected from the group consisting of lower alkyl, halo, —OH, and amino; and
W is C, CH, or N, wherein when W is C then the dashed bonds are single bonds, and W and Y join together, along with the atoms to which they are attached, to form a 5 membered ring in which Y is CH2, and wherein when W is CH or N, then the dashed bonds are absent and Y is absent.