Patent ID: 11920155
Assignee: ASTERIAS BIOTHERAPEUTICS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A container comprising a composition, wherein the composition comprises a population of cells comprising a plurality of oligodendrocyte progenitor cells (OPCs), wherein the OPCs express Nestin and one or more markers selected from PDGF-Rα, IGF2, Nkx2.2, Olig1, NG2, Olig2, FABP7, NEUROG2, wherein the population of cells comprises less than 15% undesirable cell types, and wherein the OPCs are the in vitro-derived progeny of expanded but undifferentiated stem cells that were treated with one or more stem cell differentiation modulating molecules selected from a Smoothened agonist or an inhibitor of ALK5, ALK2, or GSK3 prior to differentiation into OPCs.