Patent ID: 11897898
Assignee: BIOGEN MA INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 11:
12. The compound of claim 1, wherein:
R1 in each occurrence is independently selected from C1-6 alkyl; C2-6 alkenyl; C2-6 alkynyl; C3-6 cycloalkyl selected from cyclopropyl, cyclobutyl, cyclopentyl, and cyclohexyl; 4- to 7-membered monocyclic heterocyclyl selected from azetidinyl, pyrrolidinyl, tetrahydrofuranyl, thiolanyl, imidazolidinyl, pyrazolidinyl, oxazolidinyl, isoxazolidinyl, thiazolidinyl, oxetanyl, isothiazolidinyl, dioxolanyl, dithiolanyl, oxathiolanyl, piperidinyl, tetrahydropyranyl, thianyl, piperazinyl, morpholinyl, thiomorpholinyl, dioxanyl, dithianyl, trioxanyl, trithianyl, azepanyl, oxepanyl, thiepanyl, dihydrofuranyl, imidazolinyl, dihydropyranyl, pyrrolyl, furanyl, thienyl, imidazolyl, pyrazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, furazanyl, oxadiazolyl, thiadiazolyl, dithiazolyl, triazolyl, tetrazolyl, pyridinyl, tetrahydropyridinyl, pyranyl, thiopyranyl, pyrazinyl, pyrimidinyl, pyridazinyl, oxazinyl, thiazinyl, dioxinyl, dithiinyl, oxathianyl, triazinyl, tetrazinyl, azepinyl, oxepinyl, thiepinyl, diazepinyl, and thiazepinyl; 6- to 8-membered spiro or bridged bicyclic heterocyclyl selected from 3-azabicyclo[3.1.0]hexanyl, 3-azabicyclo[3.1.1]heptanyl, 2-azaspiro[3.3]heptanyl, 2-oxa-6-azaspiro[3.3]heptanyl, 3-oxa-8-azabicyclo[3.2.1]octanyl, 6-oxa-3-azabicyclo[3.1.1]heptanyl, 8-oxa-3-azabicyclo[3.2.1]octanyl, 3-oxa-6-azabicyclo[3.1.1]heptanyl, 5-azaspiro[2.3]hexanyl, and 4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazinyl; halo; —CN; —OR1a; —NHR1a; —C(O)R1a; and —S(O)2R1a; wherein said C1-6 alkyl, C2-6alkenyl, C2-6 alkynyl, C3-6 cycloalkyl, 4- to 7-membered monocyclic heterocyclyl, and 6- to 8-membered spiro or bridged bicyclic heterocyclyl are optionally substituted with one to four R10;
R1a in each occurrence is H, C1-6 alkyl or 4- to 7-membered monocyclic heterocyclyl selected from azetidinyl, pyrrolidinyl, imidazolidinyl, pyrazolidinyl, oxazolidinyl, isoxazolidinyl, thiazolidinyl, isothiazolidinyl, piperidinyl, piperazinyl, morpholinyl, and azepinyl, wherein said C1-6 alkyl or 4- to 7-membered monocyclic heterocyclyl is independently optionally substituted with one to three R10; and
R10 in each occurrence is independently selected from C1-6 alkyl, C3-6 cycloalkyl selected from cyclopropyl, cyclobutyl, cyclopentyl, and cyclohexyl, oxetanyl, —OR10a, —N(R10a)2, —C(O)OR10a, and halo, wherein C1-6 alkyl and C3-6 cycloalkyl are optionally substituted with one to three substituents independently selected from halo and —N(R10a)2; and
R10a is H or C1-4 alkyl.