Patent ID: 11919908
Assignee: INCYTE CORPORATION
Field: Organic fine chemistry (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 26:
27. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein:
n is 1 or 2;
each R1 is independently selected from D, C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10 aryl-C1-6 alkyl-, C3-10 cycloalkyl-C1-6 alkyl-, (5-10 membered heteroaryl)-C1-2 alkyl-, (4-10 membered heterocycloalkyl)-C1-2 alkyl-, CN, NO2, ORa1, C(O)Rb1, C(O)NRc1Rd1, C(O)ORa1, OC(O)Rb1, OC(O)NRc1Rd1, NRc1Rd1, NRc1C(O)Rb1, NRc1C(O)ORa1, NRc1C(O)NRc1Rd1, NRc1S(O)NRc1Rd1, NRc1S(O)Rb1, NRc1S(O)2Rb1, NRc1S(O)2NRc1Rd1, S(O)Rb1, S(O)NRc1Ra1, S(O)2Rc1, S(O)2NRc1Rd1, and OS(O)2Rb1, wherein the C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10 aryl-C1-6 alkyl-, C3-10 cycloalkyl-C1-6 alkyl-, (5-10 membered heteroaryl)-C1-2 alkyl-, and (4-10 membered heterocycloalkyl)-C1-2 alkyl- of R1 are each optionally substituted with 1, 2, 3, or 4 independently selected R1A substituents;
each Ra1 is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, and C2-6 alkynyl;
each Rc1 and Rd1 is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, and C2-6 alkynyl;
or, any Rc1 and Rd1 attached to the same N atom, together with the N atom to which they are attached, form a 5-6 membered heteroaryl or a 4-6 membered heterocycloalkyl group, wherein the 5-6 membered heteroaryl or 4-6 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected R1A substituents;
each Rb1 is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, and C2-6 alkynyl;
each Rz1 is independently selected from H, C2-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, and C2-6 alkynyl;
each R1A is independently selected from D, halo, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, CN, NO2, ORa11, C(O)Rb11, C(O)NRc11Rd11, C(O)ORa11, OC(O)Rb11, OC(O)NRc11Rd11, NRc11Rd11, NRc11C(O)Rb11, NRc11S(O)Rb11, NRc11S(O)NRc11Rd11, NRc11S(O)2Rb11, NRc11S(O)2NRc11Rd11, S(O)Rb11, S(O)NRc11Rd11, S(O)2Rb11, and S(O)2NRc11Rd11,
each Ra11, Rb11, Rc11, and Rd11 is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, and C2-6 alkynyl;
R2 is selected from C2-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C6-10 aryl, C3-10 cycloalkyl, 5-membered heteroaryl, 7-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10 aryl-C1-6 alkyl-, C3-10 cycloalkyl-C1-6 alkyl-, (5-10 membered heteroaryl)-C1-6 alkyl-, (4-10 membered heterocycloalkyl)-C1-6 alkyl-, ORa2, C(O)Rb2, C(O)NRc2Rd2, C(O)ORa2, OC(O)Rb2, OC(O)NRc2Rd2, NRc2Rd2, NRc2C(O)Rb2NRc2C(O)ORa2 NRc2C(O)NRc2Rd2 NRc2S(O)NRc2Rd2, NRc2S(O)Rb2, NRc2S(O)2Rb2, NRc2S(O)2NRc2Rd2, S(O)Rb2, S(O)NRc2Rd2, S(O)2Rb2, S(O)2NRc2Rd2, and OS(O)2Rb2, wherein the C2-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C6-10 aryl, C3-10 cycloalkyl, 5-membered heteroaryl, 7-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10 aryl-C1-6 alkyl-, C3-10 cycloalkyl-C1-6 alkyl-, (5-10 membered heteroaryl)-C1-6 alkyl-, and (4-10 membered heterocycloalkyl)-C1-6 alkyl- of R2 are each optionally substituted with 1, 2, 3, or 4 independently selected R2A substituents;
each Ra2, Rb2, Rc2, and Rd2 is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, and C2-6 alkynyl;
each R2A is independently selected from D, halo, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10 aryl-C1-6 alkyl-, C3-10 cycloalkyl-C1-6 alkyl-, (5-10 membered heteroaryl)-C1-6 alkyl-, (4-10 membered heterocycloalkyl)-C1-6 alkyl-, CN, NO2, ORa21, C(O)Rb21C(O)NRc21Rd21, C(O)ORa21, OC(O)Rb21, OC(O)NRc21Rd21, NRc21Rd21, NRc21C(O)Rb21, NRc21C(O)NRc21Rd21, NRc21S(O)Rb21, NRc21S(O)NRc21Rd2, NRc21S(O)2Rb21, NRc21S(O)2NRc21Rd21, S(O)Rb21, S(O)NRc21Rd21, S(O)2Rb21, and S(O)2NRc21Rd21, wherein the C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10 aryl-C1-6 alkyl-, C3-10 cycloalkyl-C1-6 alkyl-, (5-10 membered heteroaryl)-C1-6 alkyl-, and (4-10 membered heterocycloalkyl)-C1-6 alkyl- of R2A are each optionally substituted with 1, 2, 3, or 4 independently selected R2B substituents;
each Ra21, Rb21, Rc21, and Rd21 is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, and C2-6 alkynyl;
each R2B is independently selected from oxo, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, CN, NO2, ORa22, C(O)Rb22, C(O)NRc22Rd22, C(O)ORa22, OC(O)Rb22, OC(O)NRc22Rc22, NRc22Rd22, NRc22C(O)Rb22, NRc22C(O)ORa2, NRc22C(O)NRc22Rd22, NRc22S(O)Rb22 NRc22S(O)NRc22Rc22, NRc22S(O)2Rb22, NRb22S(O)2NRc22Rd22, S(O)Rb22, S(O)NRc22Ra22, S(O)2Rb22, and S(O)2NRc22Rd22, wherein the C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl of R2B are each optionally substituted with 1, 2, 3, or 4 independently selected R2C substituents; and
each Ra22, Rb22, Rc22, and Rd22 is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, and C2-6 alkynyl.