Patent ID: 11884655
Assignee: TREVENA, INC.
Field: Organic fine chemistry (Chemistry)
Classification: CPC C | IPC C

Claim 13:
14. The process of claim 13, wherein the compound of, , contacts the coupling reagent, with or without the additive, to form an intermediate having the formula of, , wherein
R2, R3, R4, and R5, are each independently selected from the group consisting of H, optionally substituted C1-C6 alkyl, optionally substituted C1-C6 hydroxyalkyl, optionally substituted C1-C6 alkoxy, optionally substituted cycloalkyl, and optionally substituted cycloheteroalkyl; or R2 and R3 are together optionally substituted cycloalkyl, or optionally substituted cycloheteroalkyl; or R4 and R5 are together optionally substituted cycloalkyl, or optionally substituted cycloheteroalkyl;
R8 is optionally substituted C1-C6 alkyl; and
X, Y, A, B, and E are defined in claim 1,, wherein the optional substituent of the C1-C6 alkyl, C1-C6 hydroxyalkyl, C1-C6 alkoxy, cycloalkyl, and cycloheteroalkyl at R2, R3, R4, and R5, and C1-C6 alkyl at R8 is each independently selected from the group consisting of C1-C6 alkyl, C1-C6 alkenyl, C1-C6 alkynyl, C5-C6 aryl, C1-C6 alkoxy, C3-C5 heteroaryl, C3-C6 cycloalkyl, C5-C6 aryloxy, —CN, —OH, oxo, halo, haloalkyl, —NO2, —CO2H, —NH2, —NH(C1-C8 alkyl), —N(C1-C8 alkyl)2, —NH(C6 aryl), —N(C5-C6 aryl)2, —CHO, —CO(C1-C6 alkyl), —CO((C5-C6) aryl), —CO2((C1-C6) alkyl), and —CO2((C5-C6) aryl).