Patent ID: 11932845
Assignee: GENOMATICA, INC.
Field: Biotechnology (Chemistry)
Classification: CPC C  Y | IPC C

Claim 5:
6. The microbial organism of claim 2, wherein:
(I) the microbial organism of part (A), (B) or (C) has decreased production of ethanol, acetate, pyruvate or alanine, or a combination thereof, relative to the microbial organism in the absence of said genetic modification;
(J) the microbial organism of part (B) has decreased production of glutamate relative to the microbial organism in the absence of said genetic modification;
(K) the microbial organism of part (C) has a genetic modification comprising increased expression of a permease, glucokinase, or a glucose facilitator, or a combination thereof relative to the microbial organism in the absence of said genetic modification;
(L) the microbial organism of part (D) has increased production of 4-hydroxybutyrate relative to the microbial organism in the absence of said genetic modification;
(M) the microbial organism of part (E) has decreased production of gamma-butyrolactone relative to the microbial organism in the absence of said genetic modification;
(N) the microbial organism of part (E) has a genetic modification comprising at least two genetic modifications that decrease expression of at least two acyl coenzyme A thioesterases relative to the microbial organism in the absence of said genetic modification;
(O) the microbial organism of part (F) has suppressed depletion of the NADH pool or increased energy efficiency in the microbial organism, or a combination thereof, relative to the microbial organism in the absence of said genetic modification;
(P) the microbial organism of part (G) has increased energy efficiency relative to the microbial organism in the absence of said genetic modification; or
(Q) the microbial organism of part (G) has increased tolerance to a range of oxygen concentrations relative to the microbial organism in the absence of said genetic modification.