Patent ID: 11866764
Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A  G | IPC A  C

Claim 0:
1. A method of treating or inhibiting a disease in a subject, comprising administering to said subject a compound having a structure according to Formula (I):, wherein R1 is a substituted or unsubstituted, 5-6 membered carbocyclic or heterocyclic aromatic ring, wherein said ring is directly attached to the carbonyl substituent of the piperazine ring in Formula (I);
R2 is a substituted or unsubstituted, carbocyclic or heterocyclic, 5-6 membered aromatic ring; and
X1 is S and X2 is O, wherein said disease is associated with elevated p38 mitogen-activated protein kinase (MAPK) enzymatic activity in a cell in said subject, thereby treating or inhibiting said disease in said subject.