Patent ID: 11896603
Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 10:
11. A method to restore or compensate for the loss α1-2-fucosylated glycans on the surface of a subject's intestinal epithelial cells caused by excessive and/or chronic alcohol consumption, comprising:
administering to the subject an effective amount of an oligosaccharide of Formula I, or a composition comprising an effective amount of an oligosaccharide of Formula I:, or a pharmaceutically acceptable salt, polymorph, solvate, or prodrug thereof, wherein:
R1-R20 are independently selected from the group consisting of H, D, halo, azide, nitro, amine, aldehyde, alkoxy, ketone, ester, carboxylic acid, hydroxyl, substituted or non-substituted (C1-C6)alkyl, substituted or non-substituted (C1-C6)heteroalkyl, substituted or non-substituted (C2-C6)alkenyl, substituted or non-substituted (C2-C6)heteroalkenyl, substituted or non-substituted (C2-C6)alkynyl, substituted or non-substituted (C2-C6)heteroalkynyl, and heterocycle; and wherein the effective amount is obtained to inhibit fecal Enterococcus faecalis and/or cytolysin in the presence of alcohol.