Patent ID: 11896655
Assignee: FRED HUTCHINSON CANCER CENTER
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C  Y | IPC A

Claim 13:
14. A method of stimulating an anti-malarial immune response in a subject comprising administering a therapeutically effective amount of a circumsporozoite protein (CSP) to the subject, wherein the CSP protein comprises
ii) a KKNSR (SEQ ID NO: 1) to SSNSS (SEQ ID NO: 2) mutation directly upstream of a SLGENDD (SEQ ID NO: 3) cleavage site in the N-terminal domain (NTD) of a wild-type Plasmodium falciparum CSP; or
iii) a KKNSR (SEQ ID NO: 1) to SSNSA (SEQ ID NO: 4) mutation directly upstream of a SLGENDD (SEQ ID NO: 3) cleavage site in the NTD of a wild-type Plasmodium falciparum CSP;, wherein the wild-type Plasmodium falciparum CSP comprises a sequence as set forth in SEQ ID NOs: 7, 10, or 19, thereby stimulating the anti-malarial immune response in the subject.