Patent ID: 11952363
Assignee: HOFFMANN-LA ROCHE, INC.
Field: Organic fine chemistry (Chemistry)
Classification: CPC C  A | IPC C

Claim 4:
5. A compound selected from:
5-[(3R,5S)-3,5-Dimethyl-4-[(4-piperazin-1-ylphenyl)methyl]piperazin-1-yl]quinoline-8-carbonitrile;
4-[(3R,5R)-3,5-Dimethyl-4-[(4-piperazin-1-ylphenyl)methyl]piperazin-1-yl]quinoline-8-carbonitrile;
5-[(3R,5S)-3,5-Dimethyl-4-[(6-piperazin-1-yl-3-pyridyl)methyl]piperazin-1-yl]quinoline-8-carbonitrile;
5-[(3S,5R)-3,5-Dimethyl-4-[(5-piperazin-1-ylpyrimidin-2-yl)methyl]piperazin-1-yl]quinoline-8-carbonitrile;
5-[(3S,5R)-3,5-Dimethyl-4-[(5-piperazin-1-yl-2-pyridyl)methyl]piperazin-1-yl]quinoline-8-carbonitrile;
5-[(3S,5R)-4-[[5-[4-[2-(Dimethylamino)acetyl]piperazin-1-yl]pyrimidin-2-yl]methyl]-3,5-dimethyl-piperazin-1-yl]quinoline-8-carbonitrile;
5-[(3S,5R)-3,5-dimethyl-4-[[5-(4-methylpiperazin-1-yl)-2-pyridyl]methyl]piperazin-1-yl]quinoline-8-carbonitrile;
5-[(3S,5R)-3,5 -Dimethyl-4-[[5-(9-oxa-3,7-diazabicyclo[3.3.1]nonan-3-yl)-2-pyridyl]methyl]piperazin-1-yl]quinoline-8-carbonitrile;
5-[(3R,5S)-3,5 -Dimethyl-4-[[5-[[(3R,4S)-4-fluoropyrrolidin-3-yl]amino]-2-pyridyl]methyl]piperazin-1-yl]quinoline-8-carbonitrile;
5-[(3R,5S)-3,5 -Dimethyl-4-[[5-[4-(pyrrolidine-2-carbonyl)piperazin-1-yl]-2-pyridyl]methyl]piperazin-1-yl]quinoline-8-carbonitrile;
5-[(3S, 5R)-4-[[5-[4-[2-(Dimethylamino)acetyl]piperazin-1-yl]-2-pyridyl]methyl]-3,5-dimethyl-piperazin-1 -yl]quinoline-8-carbonitrile;
5-[(3R, 5S)-4-[[4-[2-(Hydroxymethyl)piperazin-1-yl]phenyl]methyl]-3,5-dimethyl-piperazin-1-yl]quinoline-8-carbonitrile;
5-[(3R,5S)-3,5-Dimethyl-4-[2-oxo-2-(2-piperazin-1-yl-7,8-dihydro-5H-1,6-naphthyridin-6-yl) ethyl]piperazin-1-yl]quinoline-8-carbonitrile;
5-[(3R,5S)-3,5-Dimethyl-4-[2-oxo-2-(6-piperazin-1-yl-3,4-dihydro-1H-isoquinolin-2-yl) ethyl]piperazin-1-yl]quinoline-8-carbonitrile;
5-[(3R,5S)-3,5-dimethyl-4-[2-oxo-2-(7-piperazin-1-yl-3,4-dihydro-1H-isoquinolin-2-yl) ethyl]piperazin-1-yl]quinoline-8-carbonitrile;
5-[(3R,5S)-3,5-Dimethyl-4-[2-oxo-2-(5-piperazin-1-ylisoindolin-2-yl)ethyl]piperazin-1-yl]quinoline-8-carbonitrile;
2-[4-(8-Cyano-5-quinolyl)-2-methyl-piperazin-1-yl]-N-(4-piperazin-1-ylphenyl)acetamide;
2-[4-(8-Cyano-5-quinolyl)-2-methyl-piperazin-1-yl]-N-(1,2,3,4-tetrahydroisoquinolin-6-yl) acetamide; and
5-[3-methyl-4-[2-[4-(1-methyl-4-piperidyl)-1-piperidyl]-2-oxo-ethyl]piperazin-1-yl]quinoline-8-carbonitrile;
or a pharmaceutically acceptable salt, enantiomer or diastereomer thereof.