Patent ID: 11926667
Assignee: JANSSEN BIOTECH, INC.
Field: Biotechnology (Chemistry)
Classification: CPC C | IPC C

Claim 7:
8. The antibody of claim 1, wherein
(i) the antibody that binds to CD8
(a) binds to CD8α,
wherein optionally the antibody binds a CD8α antigen or a CD8α epitope,
wherein optionally the VH CDR1, VH CDR2, VH CDR3, VL CDR1, VL CDR2 and VL CDR3 form a binding site for an antigen of the CD8α or an epitope of the CD8a;
(b) binds to CD8β,
wherein optionally the antibody binds a CD8β antigen or a CD8β epitope,
wherein optionally the VH CDR1, VH CDR2, VH CDR3, VL CDR1, VL CDR2 and VL CDR3 form a binding site for an antigen of the CD8β or an epitope of the CD8β; or
(c) binds at the interface of CD8α and CD8β,
wherein optionally the antibody binds an antigen or an epitope at the interface of the CD8α and CD8β,
wherein optionally the VH CDR1, VH CDR2, VH CDR3, VL CDR1, VL CDR2 and VL CDR3 form a binding site for an antigen at the interface of the CD8α and CD8β or form a binding site for an epitope at the interface of the CD8α and CD8β;
(ii) the first binding domain of the multispecific antibody
(a) binds to CD8α,
wherein optionally the first binding domain binds a CD8α antigen or a CD8α epitope,
wherein optionally the VH CDR1, VH CDR2, VH CDR3, VL CDR1, VL CDR2 and VL CDR3 of the first binding domain form a binding site for an antigen of the CD8α or an epitope of the CD8α;
(b) binds to CD8β,
wherein optionally the first binding domain binds a CD8β antigen or a CD8β epitope,
wherein optionally the VH CDR1, VH CDR2, VH CDR3, VL CDR1, VL CDR2 and VL CDR3 of the first binding domain form a binding site for an antigen of the CD8β or an epitope of the CD8β; or
(c) binds at the interface of CD8α and CD8β,
wherein optionally the first binding domain binds an antigen or an epitope at the interface of the CD8α and CD8β,
wherein optionally the VH CDR1, VH CDR2, VH CDR3, VL CDR1, VL CDR2 and VL CDR3 form a binding site for an antigen at the interface of the CD8α and CD8β or form a binding site for an epitope at the interface of the CD8α and CD8β.