Patent ID: 11951102
Assignee: ALKAHEST, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A

Claim 0:
1. A method of improving visual acuity in a subject diagnosed with a retina-associated disease, the method comprising orally administering to the subject a therapeutically effective amount of a compound of Formula 2:, wherein:
A is CH2, O or N—C1-6-alkyl;
R1 is C1-6-alkyl, C1-6-haloalkyl, O—C1-6-haloalkyl, halogen;
m is 1, 2 or 3;
R2a and R2b are each independently selected from H, C1-6-alkyl, C2-6-alkenyl, C2-6-alkynyl, C3-6-cycloalkyl, COO—C1-6-alkyl, O—C1-6-alkyl, CONR2b.1 R2b.2, or halogen;
R2b.1 is H, C1-6-alkyl, C0-4-alkyl-C3-6-cycloalkyl, or C1-6-haloalkyl;
R2b.2 is H, or C1-6-alkyl;
or R2b.1 and R2b.2 are together a C3-6-alkylene group forming with the nitrogen atom a heterocyclic ring, wherein optionally one carbon atom of the ring is replaced by an oxygen atom
R3 is H, or C1-6-alkyl;
X is an anion selected from the group consisting of chloride, bromide, iodide, sulphate, phosphate, methanesulphonate, nitrate, maleate, acetate, benzoate, citrate, salicylate, fumarate, tartrate, dibenzoyltartrate, oxalate, succinate, benzoate and p-toluenesulphonate; and
j is 0, 0.5, 1, 1.5 or 2.