Patent ID: 11883492
Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 0:
1. A method of treating a chemoresistant cancer in a subject in need thereof, said method comprising administering to said subject a therapeutically effective amount of paclitaxel or docetaxel and a therapeutically effective amount of a tyrosine kinase-like orphan receptor 1 (ROR-1) antagonist antibody, thereby treating the chemoresistant cancer in said subject, wherein the chemoresistant cancer is paclitaxel resistant or docetaxel resistant and is Her2 negative, wherein said subject is receiving or has received chemotherapy, and
wherein said antibody comprises a humanized heavy chain variable region and a humanized light chain variable region, wherein said humanized heavy chain variable region comprises the sequences set forth in SEQ ID NO:1, SEQ ID NO:2, and SEQ ID NO:3; and wherein said humanized light chain variable region comprises the sequences set forth in SEQ ID NO:4, SEQ ID NO:5, and SEQ ID NO:6.