Patent ID: 11866413
Assignee: SHANGHAI XUDONG HAIPU PHARMACEUTICAL CO., LTD
Field: Organic fine chemistry (Chemistry)
Classification: CPC C | IPC C

Claim 8:
9. The refining method according to claim 3, wherein the 5-fluorouracil is synthesized by a method I, and the method I comprises the following steps:
(1) condensation reaction: methyl fluoroacetate is used as a raw material, and condensed with ethyl formate in an organic solvent of sodium methoxide to obtain a fluoroformyl acetate enol sodium salt;
(2) cyclization reaction: the fluoroformyl acetate enol sodium salt obtained in the step (1) is cyclized with O-methylisourea sulfate to obtain 2-methoxy-5-fluorouracil; and
(3) hydrolysis reaction: the 2-methoxy-5-fluorouracil obtained in the step (2) is hydrolyzed into 5-fluorouracil in a dilute hydrochloric acid.