Patent ID: 11938188
Assignee: THE GENERAL HOSPITAL CORPORATION
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 0:
1. A slurry configured for injection into a target tissue comprising:
a plurality of sterile ice particles having a largest cross-sectional dimension less than about 1.5 mm, wherein the plurality of sterile ice particles are substantially uniform in shape; and
a biocompatible surfactant, wherein the biocompatible surfactant is glycerol;
the slurry having a mean temperature in the range of about 0° C. to about −15° C.;
wherein the target tissue is selected from the group consisting of adipose tissue and a myelinated nerve; and
wherein the slurry is configured to cause the target tissue to reach a temperature in the range of about −8° C. to about 0° C. such that crystallization occurs in the target tissue and the crystallization causes localized and selective damage to the target tissue.