Patent ID: 11891667
Assignee: UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
Field: Measurement (Instruments)
Classification: CPC C  G  A | IPC C

Claim 0:
1. A method of detecting a thyroid adenoma associated (THADA) gene fusion thyroid cancer in a human patient, comprising the steps of:
obtaining a tissue sample from a thyroid tumor in the human patient; extracting chromosomal DNA, mRNA, or combinations thereof from the tissue sample; assaying the chromosomal DNA and/or mRNA for the presence of a genetic fusion event, between THADA exons 28, 29, 30, or 36 and a breakpoint located upstream of the Insulin-like growth factor 2 binding protein 3 (IGF2BP3) gene at LOC389473 including chromosome 7 position 23,521,997; wherein the presence of the THADA-LOC389473 fusion event indicates that the human patient has a THADA gene fusion cancer; wherein the chromosome 7 position 23,521,997 is with respect to genome build 37 UCSC/genome browser version 19; and
subsequently surgically removing the THADA gene fusion thyroid cancer.