Patent ID: 11890471
Assignee: SETPOINT MEDICAL CORPORATION
Field: Measurement (Instruments)
Classification: CPC A  G | IPC A  G

Claim 0:
1. An in vitro method for screening a patient for responsiveness to vagus nerve stimulation to treat an inflammatory disorder, the method comprising:
obtaining a sample of blood taken from the patient prior to stimulation of the patient's vagus nerve;
challenging the sample of blood with a first concentration of toxin;
obtaining a second sample of blood taken from the patient prior to stimulation of the patient's vagus nerve;
challenging a second sample of blood with a second concentration of toxin that is at least 2 times the first concentration;
determining an amount of inflammatory cytokine released in response to the second concentration of toxin compared to the inflammatory cytokine released in response to the first concentration of toxin; and
outputting an indication that the patient is a responder or a non-responder for vagus nerve stimulation based on the amount of inflammatory cytokine released.