Patent ID: 11939319
Assignee: UCB PHARMA GMBH
Field: Organic fine chemistry (Chemistry)
Classification: CPC C  A | IPC C

Claim 1:
2. A compound according to claim 1, wherein
X1 is N or C(R7),
R2 is hydrogen or fluoro,
R4 is hydrogen or fluoro,
R5 is hydrogen or halogen,
R6 is selected from halogen, cyano, cyclopropyl, benzyl, benzyloxy, pyridinylmethoxy, C1-2 alkoxy and C1-2 alkyl, wherein each cyclopropyl, benzyl, pyridinyl, alkyl and alkoxy can be substituted with one or more substituent selected from halogen, cyano, C1-2 alkoxy and fluoroC1-2alkoxy, or
R6 together with R7 and the C-atoms to which they are attached form a pyridyl ring, such that the pyridyl together with the bicyclic ring system to which it is annulated forms a 1H-pyrrolo[3,2-h]quinoline, wherein the pyridyl ring is substituted with one or two residues R13 or is unsubstituted,
R7, if present, is selected from hydrogen, halogen, cyclopropyl, cyclopropyloxy, C1-3alkoxy, and C1-3 alkyl, wherein each alkyl and alkoxy can be substituted with one or more substituent selected from halogen, C1-2alkoxy, fluoro(C1-2)alkoxy and cyano, or
R7 forms a ring together with R6 as described above,
R8 is selected from hydrogen, halogen, methoxy, ethoxy, fluoromethoxy and fluoroethoxy,
R10 is selected from hydrogen, cyano, halogen, C3-5 cycloalkyl, C3-5 cycloalkyloxy, C3-5 cycloalkylmethoxy, C1-4 alkoxy, and C1-4 alkyl, wherein each cycloalkyl, cycloalkyloxy, alkyl and alkoxy can be substituted with one or more substituent selected from halogen, C1-3 alkoxy, fluoro(C1-3)alkoxy and cyano,
R11 is selected from hydrogen, fluoro and methoxy,
X2 is N or C(R12),
R12 is selected from hydrogen, methoxy and halogen,
R13, in each occurrence, is independently selected from fluoro, chloro, cyano, hydroxy, methyl, methoxy, fluoromethyl and fluoromethoxy,
or a pharmaceutically acceptable salt, solvate, isotope or co-crystal thereof.