Patent ID: 11905297
Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 21:
22. The compound of claim 1, wherein the compound has the structure of formula (C):, or a pharmaceutically acceptable salt thereof, wherein
Y1 and Y2 are each independently N or CR6;
W1 and W2 are each independently 5- to 10-membered aryl, heterocyclyl, or heteroaryl, which are each optionally substituted with one or more R10;
R2 is O or NH;
R6 is hydrogen, halogen, —CN, —C1-C3 alkyl, —C3-C6 cycloalkyl, C1-C3 haloalkyl, C1-C3 alkoxy, or —C1-C3 haloalkoxy;
R7 is —C1-C3 alkylene-OH, —C1-C3 alkylene-CN, —C1-C3 alkylene-(C1-C6 alkoxy), —C1-C3 alkylene-NRaRb, —C1-C3 alkylene-OCO(optionally substituted heterocyclyl), —C1-C3 alkylene-OCOR9, —C1-C3 alkylene-NRaCOR9, —C1-C3 alkylene-NRaCO(optionally substituted heterocyclyl), —C1-C3 alkylene-NRaCONRaRb, —CONRcRd, —(C1-C3 alkylene)-O—(C1-C3 alkylene)-OH, —(C1-C3 alkylene)-O—(C1-C3 alkylene)-CN, —(C3 alkylene)-O—(C1-C3 alkylene)-O—(C1-C3 alkyl), —C1-C3 alkylene-S(C1-C6 alkyl), —C1-C3 alkylene-SO(C1-C6 alkyl), or —C1-C3 alkylene-SO2(C1-C6 alkyl);
R8 is —OH, —CN, oxo, —C1-C6 alkyl, C1-C6 alkylene-OH, —C1-C6 haloalkyl, or —C3-C6 cycloalkyl;
Ra and Rb are each independently H, —C1-C6 alkyl, —C1-C6 haloalkyl, —CHO, —CO(C1-C3 alkyl), —CO(C1-C6 alkylene)-OH, —CONReRf, —CO(C1-C3 alkylene)-NReRf, —CO(C1-C3 alkylene)-NReSRf, —CO(C1-C3 alkylene)-NReSORg, —CO(C1-C3 alkylene)-NReSO2Rf, —CO(C2-C3 alkenyl), —CO(C1-C3 haloalkyl), —CO(CH2)n(cycloalkyl), —CO(CH2)n(optionally substituted aryl), —CO(CH2)n(optionally substituted heterocyclyl), or —CO(CH2)n(optionally substituted heteroaryl);
Rc and Rd together with the nitrogen atom to which it is attached to form an optionally substituted ring, which can be monocyclic, fused bicyclic, or spiral bicyclic, wherein the ring can contain up to 3 heteroatoms selected from N, O, and S;
Re and Rf are each independently H, —C1-C6 alkyl, —C1-C6 haloalkyl, or —C1-C6 alkylene-OH;
Rg is H, —C1-C6 alkyl, —C3-C6 cycloalkyl, —C1-C6 haloalkyl, phenyl, or benzyl;
R9 is —C1-C3 alkylene-OH, —C1-C3 alkylene-CN, —C1-C3 alkylene-(C1-C3 alkoxy), or —C1-C3 alkylene-NRaRb;
R10 is halogen, —CN, oxo, —C1-C6 alkyl, —C1-C6 haloalkyl, —C1-C6 alkoxy, —C1-C6 haloalkoxy, —S—S—(C1-C6 alkyl), or optionally substituted phenyl;
and
n is 0, 1, or 2.