Patent ID: 11872324
Assignee: THE UNIVERSITY COURT OF THE UNIVERSITY OF GLASGOW
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 0:
1. An implantable construct comprising:
(a) a biocompatible substrate having a first surface, wherein the biocompatible substrate is selected from a synthetic polymer, a ceramic, a metal, an alloy and composites thereof;
(b) a material surface comprising an alkyl acrylate polymer deposited on said first surface, wherein the alkyl acrylate polymer is capable of supporting the formation of a physiological fibrillar network of FN adsorbed on its surface;
(c) fibronectin (FN) adsorbed on said material surface, wherein the FN forms a physiological fibrillar network of FN presenting colocalized growth factor binding domains and integrin binding domains; and
(d) a growth factor (GF) adsorbed on said FN, wherein said growth factor is capable of binding FNIII12-14.