Patent ID: 11938180
Assignee: SECRETARY OF STATE FOR HEALTH AND SOCIAL CARE, MINISTERIAL CORRESPONDENCE AND PUBLIC ENQUIRIES, DEPARTMENT OF HEALTH AND SOCIAL CARE
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C  Y | IPC A  C

Claim 8:
9. The poliovirus-like particle (VLP) of claim 1, which is:
(a) a type 1 VLP derived from a type 1 poliovirus with (i) a P1 having an amino acid sequence of SEQ ID NO: 16 or 17; (ii) a VP1 having an amino acid sequence of SEQ ID NO: 1, a VP0 having an amino acid sequence of SEQ ID NO: 5, and a VP3 having an amino acid sequence of SEQ ID NO: 3, (iii) a VP1 having an amino acid sequence of SEQ ID NO: 1, a VP2 having an amino acid sequence of SEQ ID NO: 2, and a VP3 having an amino acid sequence of SEQ ID NO: 3 and a VP4 having an amino acid sequence of SEQ ID NO: 4; and/or (iv) a P1; VP1, VP0 and VP3; or a VP1, VP2, VP3 and VP4 having an amino acid sequence with at least 90% sequence identity to the amino acid sequences of (i) to (iii);
(b) a type 2 VLP derived from a type 2 poliovirus with (i) a P1 having an amino acid sequence of SEQ ID NO: 18 or 19; (ii) a VP1 having an amino acid sequence of SEQ ID NO: 6, a VP0 having an amino acid sequence of SEQ ID NO: 10, and a VP3 having an amino acid sequence of SEQ ID NO: 8, (iii) a VP1 having an amino acid sequence of SEQ ID NO: 6, a VP2 having an amino acid sequence of SEQ ID NO: 7, and a VP3 having an amino acid sequence of SEQ ID NO: 8 and a VP4 having an amino acid sequence of SEQ ID NO: 9; and/or (iv) a P1; VP1, VP0 and VP3; or a VP1, VP2, VP3 and VP4 having an amino acid sequence with at least 90% sequence identity to the amino acid sequences of (i) to (iii); or
(c) a type 3 VLP derived from a type 3 poliovirus with (i) a P1 having an amino acid sequence of SEQ ID NO: 20 or 21; (ii) a VP1 having an amino acid sequence of SEQ ID NO: 11, a VP0 having an amino acid sequence of SEQ ID NO: 15, and a VP3 having an amino acid sequence of SEQ ID NO: 13, (iii) a VP1 having an amino acid sequence of SEQ ID NO: 11, a VP2 having an amino acid sequence of SEQ ID NO: 12, and a VP3 having an amino acid sequence of SEQ ID NO: 13 and a VP4 having an amino acid sequence of SEQ ID NO: 14; and/or (iv) a P1; VP1, VP0 and VP3; or a VP1, VP2, VP3 and VP4 having an amino acid sequence with at least 90% sequence identity to the amino acid sequences of (i) to (iii).