Patent ID: 11905516
Assignee: ELIGO BIOSCIENCE
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A  Y | IPC A  C

Claim 7:
8. The engineered bacteriophage or packaged phagemid according to claim 7, wherein the engineered bacteriophage or phagemid does not comprise, in non-coding regions and optionally in coding regions, the restriction sites of sequences SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 4, SEQ ID NO: 3, SEQ ID NO: 36, SEQ ID NO: 37, SEQ ID NO: 34, SEQ ID NO: 80, GGTCTC, ACCACC, GAACC and CACAG when the group of bacteria of interest is E. coli; of sequences SEQ ID NO: 6, SEQ ID NO: 1, SEQ ID NO: 37, SEQ ID NO: 34 and SEQ ID NO: 79 when the group of bacteria of interest is E. coli STEC; of sequences SEQ ID NO: 81, SEQ ID NO: 82, GGCC, GGNNCC, GGTGA, GCCGGC, SEQ ID NO: 83, RGCGCY, CCGCGG, GCSGC, CCGG, CCACC, and AGAAA when the group of bacteria of interest is Neisseria gonorrhoeae, of sequences GGNNCC, GCGCGC, CCGG, RCCGGY, CCTTC, CCAGA, GACGC and ACACC when the group of bacteria of interest is Neisseria meningitides; of sequences SEQ ID NO: 84-88, GATCAG, GGWCC, CGGCCG and CAGAG when the group of bacteria of interest is Salmonella enteritidis; of sequence TCTAGA when the group of bacteria of interest is Streptococcus pneumoniae; of sequences SEQ ID NO: 89-91 when the group of bacteria of interest is Streptococcus pyogenes, of sequence SEQ ID NO: 02 when the group of bacteria of interest is Vibrio cholera; of sequences RGCGCY, CGCG, AAGCTT, GCGC, GTYRAC, and GTCGAC when the group of bacteria of interest is Haemophilus influenza; of sequences SEQ ID NO: 93-96 and CGCATC when the group of bacteria of interest is Klebsiella pneumoniae; of sequences SEQ ID NO: 97-99, GTCGAC, CTCGAG, CTGCAG and GGCGCC when the group of bacteria of interest is Pseudomonas aeruginosa; of sequences SEQ ID NO: 100-102, CCNGG, GCNGC and GGNCC when the group of bacteria of interest is Staphylococcus aureus; of sequence SEQ ID NO: 103 when the group of bacteria of interest is Vibrio cholera; of sequences CTCGAG and GACGAG when the group of bacteria of interest is Brucella suis; of sequences SEQ ID NO: 104 and CACGCAG when the group of bacteria of interest is Mycobacterium tuberculosis; of sequence GTCGAC when the group of bacteria of interest is Enterobacter cloacae; of sequences GCNGC, GCSGC, ACGGC and CACAG when the group of bacteria of interest is Bacillus cereus; of sequence GCGGAG when the group of bacteria of interest is Corynebacterium diphtheria; of sequences SEQ ID NO: 105-108 and GKAAYG when the group of bacteria of interest is Campylobacter jejuni; of sequences SEQ ID NO: 109-112, TAGRAG, GTATCC and GTCGAC when the group of bacteria of interest is Listeria monocytogenes; of sequence SEQ ID NO: 113 when the group of bacteria of interest is Campylobacter coli; of sequences GGWCC and ACGGC when the group of bacteria of interest is Bacillus thuringiensis; of sequences GGCGCC and GCGCGC when the group of bacteria of interest is Yersinia enterocolitica; of sequences CCGG, GTNNAC, GTAC, CATG, TCNNGA, TGCA, GANTC, ACNGT, ACGT, CCATC, CCTC, CTNAG, GAAGA, GTSAC, CCNNGG, GAATTC, GGCC, TCNGA, CCTTC, CTGCAG and TCAG when the group of bacteria of interest is Helicobacter pylori; of sequences SEQ ID NO: 114, CCTTC, GGNNCC, GCGCGC, CCGG, RCCGGY, CCAGA, GACGC and ACACC when the group of bacteria of interest is Neisseria meningitides; of sequences SEQ ID NO: 115-121 and TCTAGA when the group of bacteria of interest is Streptococcus pneumoniae; of sequences SEQ ID NO: 89-91 and CCNGG when the group of bacteria of interest is Streptococcus pyogenes; of sequences SEQ ID NO: 92, CTGCAG, TCCGGA, GGCGCC, CTCGAG and GGNCC when the group of bacteria of interest is Vibrio cholera; of sequences SEQ ID NO: 122-124, RGCGCY, CGCG, AAGCTT, GCGC, GTYRAC, GTCGAC, CGAG, AGAAA, ACAGC and CGAAT when the group of bacteria of interest is Haemophilus influenza; of sequences SEQ ID NO: 97-99, SEQ ID NO: 125-131, GTCGAC, CTCGAG, CTGCAG, GGCGCC, ACGACC and GCCCAG when the group of bacteria of interest is Pseudomonas aeruginosa; of sequences SEQ ID NO: 100-102, CCNGG, GCNGC, GGNCC, SEQ ID NO: 132-133 and GCTGA when the group of bacteria of interest is Staphylococcus aureus; of sequences SEQ ID NO: 134-135, CTCGAG and GACGAG when the group of bacteria of interest is Brucella suis; of sequences SEQ ID NO: 104, CACGCAG and SEQ ID NO: 136 when the group of bacteria of interest is Mycobacterium tuberculosis; of sequences SEQ ID NO: 137-140, GTCGAC and ACGAAG when the group of bacteria of interest is Enterobacter cloacae; of sequences SEQ ID NO: 141-147, GCNGC, GCSGC, GCWGC, ACGGC, CTCGAG and CACAG when the group of bacteria of interest is Bacillus cereus; of sequences SEQ ID NO: 148-152 and GCGGAG when the group of bacteria of interest is Corynebacterium diphtheria; of sequences SEQ ID NO: 105-108, CATG and GKAAYG when the group of bacteria of interest is Campylobacter jejuni; of sequences SEQ ID NO: 109-110, SEQ ID NO: 112, SEQ ID NO: 153-155, TAGRAG, GTATCC, GTCGAC and ACANNNNCATC when the group of bacteria of interest is Listeria monocytogenes; of sequences SEQ ID NO: 156, GGWCC, ACGGC, GCNGC, GGWCC, ACGGC, GCNGC and CACAG when the group of bacteria of interest is Bacillus thuringiensis; of sequences GGCGCC, GCGCGC and CCGAG when the group of bacteria of interest is Yersinia enterocolitica; of sequences SEQ ID NO: 157-164, CCGG, GTNNAC, CATG, GTAC, TCNNGA, GANTC, TGCA, ACNGT, ACGT, CCATC, CCTC, CTNAG, GAAGA, CCNNGG, GTSAC, GAATTC, GGCC, TCNGA, CCTTC, CTGCAG and TCAG when the group of bacteria of interest is Helicobacter pylori; of sequences SEQ ID NO: 165 and ATGCAT when the group of bacteria of interest is Bacteroides fragilis; of sequences SEQ ID NO: 166, GCNGC and GCTNAGC when the group of bacteria of interest is Clostridium butyricum; of sequences SEQ ID NO: 167, GGNCC, GGCC and CCGG when the group of bacteria of interest is Streptococcus agalactiae; of sequences CAA TAYG, TNAGCC, CCNGG, GCNGC and CCCGC when the group of bacteria of interest is Leuconostoc lactis; of sequences SEQ ID NO: 168-169, CTGCAG, CCNGG, GACGTC, GAATTC and GTCGAC when the group of bacteria of interest is Shigella sonnei; of sequences SEQ ID NO: 170-172 and GATATC when the group of bacteria of interest is Zymomonas mobilis; of sequence SEQ ID NO: 173 when the group of bacteria of interest is Treponema denticola; of sequences SEQ ID NO: 174-75, GGNCC, CTCTTC, GCATC, GC SGC and CGRYCG when the group of bacteria of interest is Lactobacillus plantarum; of sequences SEQ ID NO: 176-177, CCGG, CCWWGG and GCWGC when the group of bacteria of interest is Enterococcus faecium; of sequences SEQ ID NO: 178-179, ATCGAT, GCWGC, GCNGC, GCGCGC, GGATC and GGGAC when the group of bacteria of interest is Bacillus liquefaciens; of sequences SEQ ID NO: 180-182, GGTGA and CCTC when the group of bacteria of interest is Staphylococcus epidermidis; of sequences SEQ ID NO: 183-186, GCNGC, CTGCAG, CCCGGG, GCCGGC, CCGCGG and CAGAG when the group of bacteria of interest is Serratia marcescens; of sequences SEQ ID NO: 187-190 and CGATCG when the group of bacteria of interest is Citrobacter freundii; of sequences SEQ ID NO: 191, GGCC, GCGATG, GTCGAC, CCGG and GCNGC when the group of bacteria of interest is Parvimonas micra; of sequences SEQ ID NO: 192-200, GGATG and GCCGGC when the group of bacteria of interest is Prevotella intermedia; of sequences SEQ ID NO: 201-202, GCWGC, TGATCA and CACAG when the group of bacteria of interest is Brucella melitensis; of sequences SEQ ID NO: 203, CTGCAG, CRRTAAG, CCGG, GTCGAC and GCYYGAC when the group of bacteria of interest is Aeromonas caviae; of sequences SEQ ID NO: 204-209, GRCGYC, GCWGC, GCSGC, CCGG and GCNGC when the group of bacteria of interest is Clostridium botulinum; of sequences SEQ ID NO: 210-211, GCNGC, GGWCC, GTCTC, GGCC, ACGGC and VGACAT when the group of bacteria of interest is Clostridium perfringens; of sequences SEQ ID NO: 212-213, CCGG, CCWWGG and GCWGC when the group of bacteria of interest is Enterococcus faecium; of sequence SEQ ID NO: 214 when the group of bacteria of interest is Mycoplasma pneumonia; of sequences SEQ ID NO: 215-217, GATCAG, CCNGG, CCWWGG and CAGAG when the group of bacteria of interest is Salmonella typhimurium; of sequences SEQ ID NO: 218-219, GGNCC, GGATG, CWTCCAG, GCSGC, GTCGAC, GTCGAC and GCATC when the group of bacteria of interest is Salmonella paratyphi; of sequences SEQ ID NO: 220, CTGCAG and GCCGGC when the group of bacteria of interest is Shigella flexnerii; of sequences SEQ ID NO: 221, CCNGG, CTCTTC and GNAATC when the group of bacteria of interest is Vibrio parahaemolyticus; of sequences SEQ ID NO: 222, CTGCAG and CGGAAG when the group of bacteria of interest is Yersinia pseudotuberculosis; of sequences SEQ ID NO: 223-230, GAAAGC and CGAGG when the group of bacteria of interest is Actinobacter baumanii; of sequences GGCGCC, GCCGGC and CACAG when the group of bacteria of interest is Bacteroides distasonis; of sequences GGNCC and GGATG when the group of bacteria of interest is Clostridium leptum; of sequences GCWGC, GCTNAGC and CACAG when the group of bacteria of interest is Brevibacterium lactofermentum; of sequences CCGG, CCGCGG, GATATC, CGGCCG and CTCGAG when the group of bacteria of interest is Actinobacillus actinobycetemcomitans; of sequences GCCGGC, CCGCGG and GAGAG when the group of bacteria of interest is Selnomonas ruminatium; of sequences TCTAGA, GGNCC, CCTC, CCATC, GANTC, CCTTC, GCATC and TGAG when the group of bacteria of interest is Mycoplasma mycoides; of sequence GGCGCC when the group of bacteria of interest is Staphylococcus lugdunensis; of sequence GATATC when the group of bacteria of interest is Lactobacillus rhamnosus; of sequences CCGCGG, CTGCAG and GATATC when the group of bacteria of interest is Lactobacillus casei; of sequence GGCC when the group of bacteria of interest is Lactobacillus acidophilus; of sequences ATCGAT, GRCGYC, GCSGC, CTGCAG, GTCTC, GGATCC, GAGCTC, CTCGAG, CACAG, GAWTC and TAAATC when the group of bacteria of interest is Bacillus coagulans; of sequences GTAC and CCGGNAG when the group of bacteria of interest is Pyrococcus abyssi; of sequences GGCCGAG and CCGG when the group of bacteria of interest is Selenomonas nominantium; of sequence CTRYAG when the group of bacteria of interest is Streptococcus ferus; of sequences CCNGG, GCATGC, TTAA, GTAC and CTAG when the group of bacteria of interest is Streptomyces phaechromogenes; of sequence GCCGGC when the group of bacteria of interest is Streptomyces ghanaenis; of sequences YGGCCR and GGNCC when the group of bacteria of interest is Enterobacter aerogenes; of sequences GGNNCC, CGATCG, TGCA and GC SGC when the group of bacteria of interest is Morganella morganii; of sequences GGCC, AAGCTT, ATGCAT and GCGC when the group of bacteria of interest is Fusobacterium nucleatum; of sequences GCAGT, GAGTC and GATATC when the group of bacteria of interest is Porphyromonas endodontalis; of sequence GAATTC when the group of bacteria of interest is Porphyromonas gingivalis; of sequences ACGCGT, GAGCTC and CAGNNNCTG when the group of bacteria of interest is Micrococcus luteus; of sequences CTCGAG, GCYYGAC, YAAMGAG and CAGCTG when the group of bacteria of interest is AEromonas hydrophila; of sequences RTCAGG and GGWCC when the group of bacteria of interest is Bacillus anthracis; of sequence AGTACT when the group of bacteria of interest is Bartonella henselae; of sequences GGNCC, CTGCAG, GRCGYC and AGCCGCC when the group of bacteria of interest is Bordetella pertussis; of sequence CCGG when the group of bacteria of interest is Borrelia garinii; of sequences CCATC, GGCGCC, CTNAG, GGNCC and GCCGGC when the group of bacteria of interest is Brucella canis; of sequence SEQ ID NO: 37 when the group of bacteria of interest is Campylobacter fetus; of sequences CGATCG, CCCGGG and GCCGGC when the group of bacteria of interest is Clostridium tetani; of sequences GGCC and CTGCAG when the group of bacteria of interest is Francisella tularensis; of sequences CCDG and GGNCC when the group of bacteria of interest is Legionella pneumophila; of sequences GCGC and GGCC when the group of bacteria of interest is Leptospira interrogans; of sequences RGATCY, GCWGC, CCATC, GTATCC and CTAG when the group of bacteria of interest is Leptospira santarosai; of sequence GTCGAC when the group of bacteria of interest is Leptospira weilii; of sequences GGNCC, GCATC and GTCGAC when the group of bacteria of interest is Mycobacterium leprae; of sequences SEQ ID NO: 37, CCNGG, GAATTC, GGCC and GGGAC when the group of bacteria of interest is Shigella dysenteriae; of sequences GCNGC and ACGT when the group of bacteria of interest is Staphylococcus saprophyticus; of sequence GCCGGC when the group of bacteria of interest is Streptococcus viridans; of sequences GGWCC, TCGA and GMGAGC when the group of bacteria of interest is Treponema pallidum; of sequence GCNGC when the group of bacteria of interest is Ureaplasma urealyticum; and of sequences SEQ ID NO: 231-233, AGCAGY and ACCAGG when the group of bacteria of interest is Propionibacterium acnes.