Patent ID: 11939632
Assignee: ROCHE SEQUENCING SOLUTIONS, INC.
Field: Biotechnology (Chemistry)
Classification: CPC C | IPC C

Claim 0:
1. A system for analyzing nucleic acid molecules, the system comprising:
a transistor comprising a gate electrode in contact with a semiconductor material disposed between a source electrode and a drain electrode;
a nucleic acid polymerase attached to a tether compound, the nucleic acid polymerase configured to elongate a nascent strand, wherein:
the tether compound comprises a polymer,
the polymer is affixed to the transistor,
the polymer contacts a side of the semiconductor material opposite the gate electrode, and
the tether compound comprises a nucleic acid strand attached to the polymer, a nucleotide attached to a label compound comprising a moiety;

a power supply in electrical communication with the transistor; and
a meter device configured to measure an electrical characteristic of the transistor from the moiety after the nucleic acid polymerase incorporates the nucleotide and after the nucleic acid polymerase cleaves the nucleotide from the label compound.