Patent ID: 11905522
Assignee: CLS THERAPEUTICS, LLC
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A  G | IPC A  C  G

Claim 1:
2. A method for inhibiting growth of a primary tumor in a subject having a cancer accompanied by accumulation of cell free DNA (cfDNA) in the hepatic porto-sinusoidal circulation of the subject, said method comprising administering to the subject an expression vector comprising a nucleic acid comprising a promoter operably linked to a sequence encoding an enzyme which has a deoxyribonuclease (DNase) activity, wherein the promoter is a liver specific promoter and/or wherein the vector comprises one or more molecules capable of targeting of the nucleic acid to liver cells, wherein the nucleic acid comprises the sequence of SEQ ID NO: 30 or SEQ ID NO: 31, and wherein the administration of the vector results in inhibiting growth of the primary tumor in the subject.