Patent ID: 11970555
Assignee: BICYCLETX LIMITED
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A peptide ligand specific for transferrin receptor 1 (TfR1) comprising a polypeptide comprising at least three reactive groups, separated by at least two loop sequences, and a molecular scaffold which forms covalent bonds with the reactive groups of the polypeptide such that at least two polypeptide loops are formed on the molecular scaffold, wherein said polypeptide comprises an amino acid sequence selected from:, (SEQ ID NO: 1)

CiALCiiNDWTLPWHHCiii;

 

(SEQ ID NO: 2)

CiREFFDTCiiGLAFIECiii;

 

(SEQ ID NO: 3)

CiLEACiiYDGVYWYSCiii;

 

(SEQ ID NO: 4)

CiSADDWLGCiiISWCiii;

 

(SEQ ID NO: 5)

CiSSDAYLGCiiISWCiii;

 

(SEQ ID NO: 6)

CiPPDAHLGCiiISWCiii;

 

(SEQ ID NO: 7)

CiPQDAYLGCiiISWCiii;

 

(SEQ ID NO: 8)

CiPPDSWQGCiiISYCiii;

 

(SEQ ID NO: 9)

CiSPDAHLGCiiISYCiii;

 

(SEQ ID NO: 10)

CiPGDAHLGCiiISYCiii;

 

(SEQ ID NO: 11)

CiPPDSHLGCiiISYCiii;

 

(SEQ ID NO: 12)

CiSADDWLGCiiISYCiii;

 

(SEQ ID NO: 13)

CiP[HyP]DAYLGCii[tBuGly]SYCiii;

 

(SEQ ID NO: 14)

CiP[HyP]DAYLGCiiISYCiii;

 

(SEQ ID NO: 15)

CiS[HyP]DAHLGCiiISYCiii;

 

(SEQ ID NO: 16)

CiP[Aib]DAHLGCii[tBuGly]SYCiii;

 

(SEQ ID NO: 17)

CiPPDAHLGCiiISYCiii;

 

(SEQ ID NO: 18)

CiP[Aib]DAYLGCii[tBuGly]SYCiii;

 

(SEQ ID NO: 19)

CiSADAHLGCiiISYCiii;

 

(SEQ ID NO: 20)

CiS[Aib]DAHLGCii[tBuGly]SYCiii;

 

(SEQ ID NO: 21)

CiSPDAHLGCii[EPA]SYCiii;

 

(SEQ ID NO: 22)

CiPPDAYLGCii[tBuGly]SYCiii;

 

(SEQ ID NO: 23)

CiS[Aib]DAYLGCii[tBuGly]SYCiii;

 

(SEQ ID NO: 24)

CiAPDAHLGCiiISYCiii;

 

(SEQ ID NO: 25)

CiP[Aib]DAHLGCiiISYCiii;

 

(SEQ ID NO: 26)

CiSPDAYLGCii[tBuGly]SYCiii;

 

(SEQ ID NO: 27)

CiSPDAHLGCii[tBuGly]SYCiii;

 

(SEQ ID NO: 28)

CiPNDAHLGCiiISYCiii;

 

(SEQ ID NO: 29)

CiPIDAHLGCiiISYCiii;

 

(SEQ ID NO: 30)

CiSPDAYLGCiiISYCiii;

 

(SEQ ID NO: 31)

CiPPDAYLGCiiISYCiii;

 

(SEQ ID NO: 32)

CiS[Aib]DAHLGCiiISYCiii;

 

(SEQ ID NO: 33)

CiSPDAHLGCii[Chg]SYCiii;

 

(SEQ ID NO: 34)

CiAPDAHLGCiiISYCiii;

 

(SEQ ID NO: 35)

CiYLPDW[tBuAla]CiiGDEYCiii;

 

(SEQ ID NO: 36)

CiSPDAHLGCiiIS[2Nal]Ciii;

 

(SEQ ID NO: 37)

CiSPDAHLGCiiIS[3tBuTyr]Ciii;

 

(SEQ ID NO: 38)

CiSPD[Aib]HLGCiiISYCiii;

 

(SEQ ID NO: 39)

CiSPDAHLGCiiIS[1Nal]Ciii;

 

(SEQ ID NO: 40)

CiSPDAH[tBuAla]GCiiISYCiii;

 

(SEQ ID NO: 41)

CiSPDAH[Cba]GCiiISYCiii;

 

(SEQ ID NO: 42)

CiSPDAHLGCiiISWCiii;

 

(SEQ ID NO: 43)

CiSPD[Abu]HLGCiiISYCiii;

 

(SEQ ID NO: 44)

CiS[Aze]DAHLGCiiISYCiii;

 

(SEQ ID NO: 45)

CiSPDDHLGCiiISYCiii;

 

(SEQ ID NO: 46)

CiSPDSHLGCiiISYCiii;

 

(SEQ ID NO: 47)

CiSPDAH[Abu]GCiiISYCiii;

 

(SEQ ID NO: 48)

CiSPDAHLGCiiIS[4Pal]Ciii;

 

(SEQ ID NO: 49)

CiP[dA]DAHLGCiiISYCiii;

 

(SEQ ID NO: 50)

CiSPDAYLGCii[tBuAla]SYCiii;

 

(SEQ ID NO: 51)

CiSPDAHLGCii[C5g]SYCiii;

 

(SEQ ID NO: 52)

CiSPDAHLGCii[Cbg]SYCiii;

 

(SEQ ID NO: 53)

CiSPDAHL[dA]CiiISYCiii;

 

(SEQ ID NO: 54)

CiSPDAH[Aib]GCiiISYCiii;

 

(SEQ ID NO: 55)

CiSPDAHLGCii[Cpg]SYCiii;

 

(SEQ ID NO: 56)

CiSPDAHLGCii[B-Melle]SYCiii;

 

(SEQ ID NO: 57)

CiSADAHLGCiiISYCiii;

 

(SEQ ID NO: 58)

CiSPAAHLGCiiISYCiii;

 

(SEQ ID NO: 59)

CiSPDAALGCiiISYCiii;

 

(SEQ ID NO: 60)

CiSPDAHAGCiiISYCiii;

 

(SEQ ID NO: 61)

CiSPDAHLACiiISYCiii;

 

(SEQ ID NO: 62)

CiSPDAHLGCiiASYCiii;

 

(SEQ ID NO: 63)

CiSPDAHLGCiiIAYCiii;

 

(SEQ ID NO: 64)

CiSPDAHLGCiiISACiii;

 

(SEQ ID NO: 65)

Ci[K(N3)]PDAHLGCiiISYCiii;

 

(SEQ ID NO: 66)

CiS[K(N3)]DAHLGCiiISYCiii;

and

 

(SEQ ID NO: 67)

CiSPD[K(N3)]HLGCiiISYCiii;

wherein Abu represents aminobutyric acid, Aib represents aminoisobutyric acid, Aze represents azetidine, B-MeIle represents beta-methyl isoleucine, C5g represents cyclopentyl glycine, Cba represents β-cyclobutylalanine, Cbg represents cyclobutyl glycine, Chg represents cyclohexyl glycine, Cpg represents cyclopropryl glycine, EPA represents 2-amino-3-ethyl-pentanoic acid, HyP represents trans-4-hydroxy-L-proline, [K(N3)] represents 6-azido lysine, 1Nal represents 1-naphthylalanine, 2Nal represents 2-naphthylalanine, 4Pal represents 4-pyridylalanine, tBuAla represents t-butyl-alanine, tBuGly represents t-butyl-glycine, 3tBuTyr represents 3-t-Butyl-tyrosine, and Ci, Cii, and Ciii, represent first, second, and third cysteine residues, respectively; or a modified derivative thereof, or a pharmaceutically acceptable salt thereof.