Patent ID: 11857275
Assignee: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
Field: Medical technology (Instruments)
Classification: CPC A  G | IPC A  G

Claim 11:
12. A targeted neuromodulation method, comprising:
obtaining patient brain data, where the patient brain data comprises a structural magnetic resonance imaging (sMRI) scan and at least one functional magnetic resonance imaging (fMRI) scan of a patient's brain;
assigning a plurality of pairs of voxels in the fMRI scan a large-scale brain network from a plurality of large-scale brain networks;
calculating a functional connectivity score for each pair of the plurality of pairs of voxels;
for each given voxel in the plurality of voxels:
calculating a first average functional connectivity score for as the average of functional connectivity scores from given pairs of voxels in the plurality of pairs of voxels where the given voxel is in the given pair of voxels and where each voxel in the given pair of voxels is within the same large-scale brain network;
calculating a second average functional connectivity score as the average of functional connectivity scores from given pairs of voxels in the plurality of pairs of voxels where the given voxel is in the given pair of voxels and where each voxel in the given pair of voxels is from a different large-scale brain network; and
calculating a network fit for the given voxel by subtracting the second average functional connectivity score from the first functional connectivity score;

calculating a network quality control metric as an average of all the network fits;
identifying the fMRI scan as passing a quality control test when the average network when the network quality control metric is above a threshold, and as failing the quality control test when the network quality control metric is below the threshold; and
when the quality control test is passed:
mapping a reference region of interest (ROI) and at least one search ROI to the patient's brain using the sMRI scan and at least one fMRI scan:
where the reference ROI describes a region to be indirectly impacted via a brain stimulation therapy; and
where the at least one search ROI describes at least one region to be directly targeted by the brain stimulation therapy;
deriving an individualized map of ROI parcellation, where the individualized map of ROI parcellation describes the reference ROI as a plurality of reference parcels, and describes the at least one search ROI as a plurality of candidate parcels;
extracting relationships between the plurality of candidate parcels and the plurality of reference parcels;
calculating a target score for candidate parcels in the plurality of candidate parcels based on the extracted relationships;
selecting a target parcel from the plurality of candidate parcels based on the target score; and
providing the target parcel; and

discarding the fMRI scan when the quality control test is failed.