Patent ID: 11866428
Assignee: ASTEX THERAPEUTICS LIMITED
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 13:
14. The protected form of formula (I) as defined in claim 1, wherein the compound of formula (I) is the free base of a compound selected from:
1-(6-Bromo-2,3-dihydro-indol-1-yl)-2-((R)-3-methyl-piperazin-1-yl)-ethanone;
1-[6-(Methyl-phenyl-amino)-2,3-dihydro-indol-1-yl]-2-((R)-3-methyl-piperazin-1-yl)-ethanone Trifluoroacetate salt;
2-((R)-3-Methyl-piperazin-1-yl)-1-(6-phenylamino-2,3-dihydro-indol-1-yl)-ethanone Trifluoroacetate salt;
1-(6-Chloro-2,3-dihydro-indol-1-yl)-2-((R)-3-methyl-piperazin-1-yl)-ethanone;
1-(6-Methoxy-2,3-dihydro-indol-1-yl)-2-((R)-3-methyl-piperazin-1-yl)-ethanone;
1-(6-Methyl-2,3-dihydro-indol-1-yl)-2-((R)-3-methyl-piperazin-1-yl)-ethanone;
1-(6-Amino-2,3-dihydro-indol-1-yl)-2-((R)-3-methyl-piperazin-1-yl)-ethanone;
N-{1-[2-((R)-3-Methyl-piperazin-1-yl)-acetyl]-2,3-dihydro-1H-indol-6-yl}-methanesulfonamide;
1-(5-Fluoro-2,3-dihydro-indol-1-yl)-2-((R)-3-methyl-piperazin-1-yl)-ethanone;
1-(6-Fluoro-2,3-dihydro-indol-1-yl)-2-((R)-3-methyl-piperazin-1-yl)-ethanone;
1-(5-Bromo-2,3-dihydro-indol-1-yl)-2-((R)-3-methyl-piperazin-1-yl)-ethanone;
1-(6-Bromo-2,3-dihydro-indol-1-yl)-2-((2S,5R)-2-isopropyl-5-methyl-piperazin-1-yl)-ethanone;
1-(6-Isopropyl-2,3-dihydro-indol-1-yl)-2-((R)-3-methyl-piperazin-1-yl)-ethanone;
1-(2,3-Dihydro-pyrrolo[3,2-c]pyridin-1-yl)-2-((R)-3-methyl-piperazin-1-yl)-ethanone;
1-[2-((R)-3-Methyl-piperazin-1-yl)-acetyl]-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester;
1-[2-((R)-3-Methyl-piperazin-1-yl)-acetyl]-2,3-dihydro-1H-indole-6-carboxylic acid methylamide;
1-[2-((R)-3-Methyl-piperazin-1-yl)-acetyl]-2,3-dihydro-1H-indole-6-carboxylic acid dimethylamide;
2-((R)-3-Methyl-piperazin-1-yl)-1-[6-(pyrrolidine-1-carbonyl)-2,3-dihydro-indol-1-yl]-ethanone;
1-(4-Chloro-3,3-dimethyl-2,3-dihydro-indol-1-yl)-2-((R)-3-methyl-piperazin-1-yl)-ethanone;
1-(6-Chloro-3,3-dimethyl-2,3-dihydro-indol-1-yl)-2-((R)-3-methyl-piperazin-1-yl)-ethanone;
1-(3,3-Dimethyl-2,3-dihydro-indol-1-yl)-2-((R)-3-methyl-piperazin-1-yl)-ethanone;
2-((R)-3-Methyl-piperazin-1-yl)-1-(6-trifluoromethyl-2,3-dihydro-indol-1-yl)-ethanone;
Benzyl 6-chloro-1-{2-[(3R)-3-methylpiperazin-1-yl]acetyl}-1,2-dihydrospiro[indole-3,4′-piperidine]-1′-carboxylate hydrochloride salt;
1-(5-Fluoro-6-phenyl-2,3-dihydro-indol-1-yl)-2-((R)-3-methyl-piperazin-1-yl)-ethanone hydrochloride salt;
5-Bromo-1-[2-((R)-3-methyl-piperazin-1-yl)-acetyl]-2,3-dihydro-1H-indole-6-sulfonic acid methylamide hydrochloride salt;
5-Bromo-1-[2-((R)-3-methyl-piperazin-1-yl)-acetyl]-2,3-dihydro-1H-indole-6-sulfonic acid dimethylamide hydrochloride salt;
1-[2-((R)-3-Methyl-piperazin-1-yl)-acetyl]-2,3-dihydro-1H-indole-6-sulfonic acid methylamide;
2-((R)-3-Methyl-piperazin-1-yl)-1-(6-trifluoromethoxy-2,3-dihydro-indol-1-yl)-ethanone hydrochloride salt;
1-(6-Benzyl-2,3-dihydro-indol-1-yl)-2-((R)-3-methyl-piperazin-1-yl)-ethanone hydrochloride salt;
1-(6-Methanesulfonyl-2,3-dihydro-indol-1-yl)-2-((R)-3-methyl-piperazin-1-yl)-ethanone hydrochloride salt;
1-{1′-Acetyl-6-chloro-1,2-dihydrospiro[indole-3,4′-piperidine]-1-yl}-2-[(3R)-3-methylpiperazin-1-yl]ethan-1-one hydrochloride salt;
1-[2-((R)-3-Methyl-piperazin-1-yl)-acetyl]-2,3-dihydro-1H-indole-6-sulfonic acid dimethylamide;
1-(6-Benzenesulfonyl-2,3-dihydro-indol-1-yl)-2-((R)-3-methyl-piperazin-1-yl)-ethanone hydrochloride salt;
1-(6-Chloro-2,3-dihydro-pyrrolo[3,2-c]pyridin-1-yl)-2-((R)-3-methyl-piperazin-1-yl)-ethanone hydrochloride salt;
1-(6-Benzyl-2,3-dihydro-pyrrolo[3,2-c]pyridin-1-yl)-2-((R)-3-methyl-piperazin-1-yl)-ethanone hydrochloride salt;
1-(2,3-Dihydro-pyrrolo[2,3-b]pyridin-1-yl)-2-((R)-3-methyl-piperazin-1-yl)-ethanone dihydrochloride salt;
2-((R)-3-Methyl-piperazin-1-yl)-1-[6-(pyrrolidine-1-sulfonyl)-2,3-dihydro-indol-1-yl]-ethanone hydrochloride salt;
1-[6-(5-Chloro-2-fluoro-phenyl)-2,3-dihydro-pyrrolo[3,2-c]pyridin-1-yl]-2-((R)-3-methyl-piperazin-1-yl)-ethanone hydrochloride salt;
6-Benzyl-1-[2-((R)-3-methyl-piperazin-1-yl)-acetyl]-1,2,3,6-tetrahydro-pyrrolo[2,3-c]pyridin-5-one hydrochloride salt;
1-(6-Chloro-3,3-dimethyl-2,3-dihydro-indol-1-yl)-2-((2R,5R)-2-hydroxymethyl-5-methyl-piperazin-1-yl)-ethanone hydrochloride salt;
1-(6-Benzenesulfonyl-5-fluoro-2,3-dihydro-indol-1-yl)-2-((R)-3-methyl-piperazin-1-yl)-ethanone;
1-(6-Benzyl-3,3-dimethyl-2,3-dihydro-indol-1-yl)-2-((2R,5R)-2-hydroxymethyl-5-methyl-piperazin-1-yl)-ethanone trifluoroacetate salt;
1-(6-Benzenesulfonyl-3,3-dimethyl-2,3-dihydro-indol-1-yl)-2-((R)-3-methyl-piperazin-1-yl)-ethanone hydrochloride salt;
1-(6-Chloro-3,3-dimethyl-2,3-dihydro-indol-1-yl)-2-((2R,5R)-2-methoxymethyl-5-methyl-piperazin-1-yl)-ethanone hydrochloride salt;
N-{(2R,5R)-1-[2-(6-Chloro-3,3-dimethyl-2,3-dihydro-indol-1-yl)-2-oxo-ethyl]-5-methyl-piperazin-2-ylmethyl}-acetamide hydrochloride salt;
1-(4,6-Dichloro-3,3-dimethyl-2,3-dihydro-indol-1-yl)-2-((R)-3-methyl-piperazin-1-yl)-ethanone hydrochloride salt;
1-(6-Benzenesulfonyl-5-fluoro-3,3-dimethyl-2,3-dihydro-indol-1-yl)-2-((R)-3-methyl-piperazin-1-yl)-ethanone dihydrochloride salt;
1-(6-Benzenesulfonyl-5-fluoro-3,3-dimethyl-2,3-dihydro-indol-1-yl)-2-((2S,5R)-2-ethyl-5-methyl-piperazin-1-yl)-ethanone dihydrochloride salt;
1-[5-Fluoro-3,3-dimethyl-6-(pyrrolidine-1-sulfonyl)-2,3-dihydro-indol-1-yl]-2-((R)-3-methyl-piperazin-1-yl)-ethanone dihydrochloride salt;
1-{6′-Chloro-1′,2′-dihydrospiro[cyclopentane-1,3′-indole]-1′-yl}-2-[(3R)-3-methylpiperazin-1-yl]ethan-1-one hydrochloride salt;
1-(6-Ethanesulfonyl-5-fluoro-3,3-dimethyl-2,3-dihydro-indol-1-yl)-2-((R)-3-methyl-piperazin-1-yl)-ethanone dihydrochloride salt;
1-[5-Fluoro-3,3-dimethyl-6-(propane-2-sulfonyl)-2,3-dihydro-indol-1-yl]-2-((R)-3-methyl-piperazin-1-yl)-ethanone dihydrochloride salt;
1-{6′-Chloro-1′,2′-dihydrospiro[cyclopropane-1,3′-indole]-1′-yl}-2-[(3R)-3-methylpiperazin-1-yl]ethan-1-one hydrochloride salt;
(2R,5R)-1-[2-(6-Chloro-3,3-dimethyl-2,3-dihydro-indol-1-yl)-2-oxo-ethyl]-5-methyl-piperazine-2-carboxylic acid methylamide hydrochloride salt;
1-{6′-Chloro-1′,2′-dihydrospiro[cyclobutane-1,3′-indole]-1′-yl}-2-[(3R)-3-methylpiperazin-1-yl]ethan-1-one hydrochloride salt;
(2R,5R)-1-[2-(6-Benzenesulfonyl-5-fluoro-3,3-dimethyl-2,3-dihydro-indol-1-yl)-2-oxo-ethyl]-5-methyl-piperazine-2-carboxylic acid methylamide hydrochloride salt;
1-(6-Cyclopropanesulfonyl-5-fluoro-3,3-dimethyl-2,3-dihydro-indol-1-yl)-2-((R)-3-methyl-piperazin-1-yl)-ethanone dihydrochloride salt;
1-(6-Benzenesulfonyl-5-fluoro-3,3-dimethyl-2,3-dihydro-indol-1-yl)-2-((2R,5R)-2-methoxymethyl-5-methyl-piperazin-1-yl)-ethanone hydrochloride salt;
1-(6-Ethanesulfonyl-3,3-dimethyl-2,3-dihydro-indol-1-yl)-2-((2R,5R)-2-methoxymethyl-5-methyl-piperazin-1-yl)-ethanone dihydrochloride salt;
1-[5-Fluoro-6-(4-methoxy-benzenesulfonyl)-3,3-dimethyl-2,3-dihydro-indol-1-yl]-2-((2R,5R)-2-methoxymethyl-5-methyl-piperazin-1-yl)-ethanone dihydrochloride salt;
1-[2-((2R,5R)-2-Methoxymethyl-5-methyl-piperazin-1-yl)-acetyl]-3,3-dimethyl-2,3-dihydro-1H-indole-6-sulfonic acid methylamide dihydrochloride salt;
1-(6-Chloro-3,3-dimethyl-2,3-dihydro-pyrrolo[3,2-c]pyridin-1-yl)-2-((2R,5R)-2-methoxymethyl-5-methyl-piperazin-1-yl)-ethanone hydrochloride salt;
1-(6-Benzyl-3,3-dimethyl-2,3-dihydro-pyrrolo[3,2-c]pyridin-1-yl)-2-((2R,5R)-2-methoxymethyl-5-methyl-piperazin-1-yl)-ethanone hydrochloride salt;
1-[3,3-Dimethyl-6-(2-methyl-propane-1-sulfonyl)-2,3-dihydro-indol-1-yl]-2-((2R,5R)-2-methoxymethyl-5-methyl-piperazin-1-yl)-ethanone dihydrochloride salt;
1-(5-Methoxy-3,3-dimethyl-2,3-dihydro-pyrrolo[2,3-c]pyridin-1-yl)-2-((2R,5R)-2-methoxymethyl-5-methyl-piperazin-1-yl)-ethanone hydrochloride salt;
1-[2-((2R,5R)-2-Methoxymethyl-5-methyl-piperazin-1-yl)-acetyl]-3,3,6-trimethyl-1,2,3,6-tetrahydro-pyrrolo[2,3-c]pyridin-5-one hydrochloride salt;
6-Benzyl-1-[2-((2R,5R)-2-methoxymethyl-5-methyl-piperazin-1-yl)-acetyl]-3,3-dimethyl-1,2,3,6-tetrahydro-pyrrolo[2,3-c]pyridin-5-one hydrochloride salt;
1-[2-((2R,5R)-2-Methoxymethyl-5-methyl-piperazin-1-yl)-acetyl]-3,3-dimethyl-2,3-dihydro-1H-indole-6-sulfonic acid dimethylamide dihydrochloride salt;
1-[2-((2R,5R)-2-Methoxymethyl-5-methyl-piperazin-1-yl)-acetyl]-3,3-dimethyl-2,3-dihydro-1H-indole-6-sulfonic acid isopropylamide dihydrochloride salt;
1-(3,3-Dimethyl-6-phenylmethanesulfonyl-2,3-dihydro-indol-1-yl)-2-((2R,5R)-2-methoxymethyl-5-methyl-piperazin-1-yl)-ethanone dihydrochloride salt;
1-{1-Acetyl-6′-chloro-1′,2′-dihydrospiro[azetidine-3,3′-indole]-1′-yl}-2-[(2R,5R)-2-(methoxymethyl)-5-methylpiperazin-1-yl]ethan-1-one hydrochloride salt;
1-(6-Isobutyl-3,3-dimethyl-2,3-dihydro-pyrrolo[3,2-c]pyridin-1-yl)-2-((2R,5R)-2-methoxymethyl-5-methyl-piperazin-1-yl)-ethanone;
6-Isobutyl-1-[2-((2R,5R)-2-methoxymethyl-5-methyl-piperazin-1-yl)-acetyl]-3,3-dimethyl-1,2,3,6-tetrahydro-pyrrolo[2,3-c]pyridin-5-one hydrochloride salt;
1-(3,3-Dimethyl-6-phenoxy-2,3-dihydro-pyrrolo[3,2-c]pyridin-1-yl)-2-((2R,5R)-2-methoxymethyl-5-methyl-piperazin-1-yl)-ethanone hydrochloride salt;
1-[3,3-Dimethyl-6-(3-methyl-butyl)-2,3-dihydro-pyrrolo[3,2-c]pyridin-1-yl]-2-((2R,5R)-2-methoxymethyl-5-methyl-piperazin-1-yl)-ethanone;
1-{1-Acetyl-6′-benzyl-1′,2′-dihydrospiro[azetidine-3,3′-indole]-1′-yl}-2-[(2R,5R)-2-(methoxymethyl)-5-methylpiperazin-1-yl]ethan-1-one hydrochloride salt;
1-{6-[(2-Fluorophenyl)methyl]-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl}-2-[(2R,5R)-2-(methoxymethyl)-5-methylpiperazin-1-yl]ethan-1-one;
1-{6-[(2-Chlorophenyl)methyl]-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl}-2-[(2R,5R)-2-(methoxymethyl)-5-methylpiperazin-1-yl]ethan-1-one hydrochloride salt;
1-[6-(Cyclohexylmethyl)-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl]-2-[(2R,5R)-2-(methoxymethyl)-5-methylpiperazin-1-yl]ethan-1-one;
3-[(1-{2-[(2R,5R)-2-(Methoxymethyl)-5-methylpiperazin-1-yl]acetyl}-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-6-yl)methyl]benzonitrile hydrochloride salt;
1-(3,3-Dimethyl-6-phenylamino-2,3-dihydro-pyrrolo[3,2-c]pyridin-1-yl)-2-((2R,5R)-2-methoxymethyl-5-methyl-piperazin-1-yl)-ethanone hydrochloride salt;
1-[6-(4-Chloro-benzyl)-3,3-dimethyl-2,3-dihydro-pyrrolo[3,2-c]pyridin-1-yl]-2-((2R,5R)-2-methoxymethyl-5-methyl-piperazin-1-yl)-ethanone;
1-(3,3-Dimethyl-6-o-tolyloxy-2,3-dihydro-pyrrolo[3,2-c]pyridin-1-yl)-2-((2R,5R)-2-methoxymethyl-5-methyl-piperazin-1-yl)-ethanone hydrochloride salt;
1-[3,3-Dimethyl-6-(methyl-phenyl-amino)-2,3-dihydro-pyrrolo[3,2-c]pyridin-1-yl]-2-((2R,5R)-2-methoxymethyl-5-methyl-piperazin-1-yl)-ethanone hydrochloride salt;
1-(2,3-Dihydro-1H-indol-1-yl)-2-[(3R)-3-methylpiperazin-1-yl]ethan-1-one, hydrochloride salt;
1-{6-[(3-Chlorophenyl)methyl]-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl}-2-[(2R,5R)-2-(methoxymethyl)-5-methylpiperazin-1-yl]ethan-1-one, hydrochloride salt;
1-[3,3-Dimethyl-6-(1-phenylethyl)-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl]-2-[(2R,5R)-2-(methoxymethyl)-5-methylpiperazin-1-yl]ethan-1-one, hydrochloride salt;
1-{6-[(4-Fluorophenyl)methyl]-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl}-2-[(2R,5R)-2-(methoxymethyl)-5-methylpiperazin-1-yl]ethan-1-one, hydrochloride salt;
2-[(2R,5R)-2-(Methoxymethyl)-5-methylpiperazin-1-yl]-1-{6-[(3-methoxyphenyl)methyl]-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl}ethan-1-one, hydrochloride salt;
1-[6-(Cyclopent-1-en-1-yl)-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl]-2-[(2R,5R)-2-(methoxymethyl)-5-methylpiperazin-1-yl]ethan-1-one, hydrochloride salt;
1-{6-Benzyl-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl}-2-[(2S,5R)-2-ethyl-5-methylpiperazin-1-yl]ethan-1-one, hydrochloride salt;
1-{6-Cyclopentyl-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl}-2-[(2R,5R)-2-(methoxymethyl)-5-methylpiperazin-1-yl]ethan-1-one, hydrochloride salt;
1-[3,3-Dimethyl-6-(1-phenylethenyl)-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl]-2-[(2R,5R)-2-(methoxymethyl)-5-methylpiperazin-1-yl]ethan-1-one, hydrochloride salt;
1-(6-Benzyl-3,3-dimethyl-2,3-dihydro-1H-indol-1-yl)-2-[(2R,5R)-2-(methoxymethyl)-5-methylpiperazin-1-yl]ethan-1-one, hydrochloride salt;
1-[3,3-Dimethyl-6-(1H-pyrazol-1-ylmethyl)-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl]-2-[(2S,5R)-2-ethyl-5-methylpiperazin-1-yl]ethan-1-one;
1-{6-Benzoyl-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl}-2-[(2R,5R)-2-(methoxymethyl)-5-methylpiperazin-1-yl]ethan-1-one, dihydrochloride salt;
1-{6-[(3-Fluorophenyl)methyl]-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl}-2-[(2R,5R)-2-(methoxymethyl)-5-methylpiperazin-1-yl]ethan-1-one, hydrochloride salt;
2-[(2R,5R)-2-(Methoxymethyl)-5-methylpiperazin-1-yl]-1-{6-[(4-methoxyphenyl)methyl]-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl}ethan-1-one, hydrochloride salt;
(2R,5R)-1-(2-{6-Benzyl-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl}-2-oxoethyl)-N,N,5-trimethylpiperazine-2-carboxamide, hydrochloride salt;
2-[(2R,5R)-2-[(Azetidin-1-yl)carbonyl]-5-methylpiperazin-1-yl]-1-{6-benzyl-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl}ethan-1-one, hydrochloride salt;
1-{6-Benzyl-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl}-2-[(2R,5R)-5-methyl-2-[(morpholin-4-yl)carbonyl]piperazin-1-yl]ethan-1-one, hydrochloride salt;
1-(1-{2-[(2R,5R)-2-(Methoxymethyl)-5-methylpiperazin-1-yl]acetyl}-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-6-yl)pyrrolidin-2-one, hydrochloride salt;
1-{2-[(2R,5R)-2-(Methoxymethyl)-5-methylpiperazin-1-yl]acetyl}-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridine-6-carbonitrile;
(2R,5R)-1-(2-{6-Benzyl-3-[(benzyloxy)methyl]-3-methyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl}-2-oxoethyl)-N,N,5-trimethylpiperazine-2-carboxamide, hydrochloride salt;
1-{6-[(2,4-Difluorophenyl)methyl]-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl}-2-[(2R,5R)-2-(methoxymethyl)-5-methylpiperazin-1-yl]ethan-1-one, hydrochloride salt;
1-[6-(Cyclohex-1-en-1-yl)-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl]-2-[(2R,5R)-2-(methoxymethyl)-5-methylpiperazin-1-yl]ethan-1-one, hydrochloride salt;
1-(3-Benzyl-6-chloro-3-methyl-2,3-dihydro-1H-indol-1-yl)-2-[(2R,5R)-2-(methoxymethyl)-5-methylpiperazin-1-yl]ethan-1-one, hydrochloride salt;
1-(6-Chloro-3,3-dimethyl-2,3-dihydro-indol-1-yl)-2-[(2R,5R)-5-methyl-2-(morpholine-4-carbonyl)-piperazin-1-yl]-ethanone, hydrochloride salt;
1′-{2-[(2R,5R)-5-Methyl-2-[(morpholin-4-yl) carbonyl]piperazin-1-yl]acetyl}-1,1′,2′,3-tetrahydrospiro[indene-2,3′-indole]-6′-carbonitrile, hydrochloride salt;
1-[6-(2-Chloro-phenoxy)-3,3-dimethyl-2,3-dihydro-pyrrolo[3,2-c]pyridin-1-yl]-2-((2R,5R)-2-methoxymethyl-5-methyl-piperazin-1-yl)-ethanone, hydrochloride salt;
1-(6-Benzyl-3,3-dimethyl-2,3-dihydro-indol-1-yl)-2-[(2R,5R)-5-methyl-2-(morpholine-4-carbonyl)-piperazin-1-yl]-ethanone, hydrochloride salt;
1-(6-Benzyl-3,3-dimethyl-2,3-dihydro-pyrrolo[3,2-c]pyridin-1-yl)-2-((2R,5R)-5-methyl-2-pyrazol-1-ylmethyl-piperazin-1-yl)-ethanone;
1-{6-Benzyl-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl}-2-[3-(trifluoromethyl)piperazin-1-yl]ethan-1-one;
1-{6-Benzyl-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl}-2-[3-(fluoromethyl)piperazin-1-yl]ethan-1-one;
1-{6-Benzyl-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl}-2-[(3S)-3-(fluoromethyl)piperazin-1-yl]ethan-1-one;
1-{6-Benzyl-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl}-2-[(3R)-3-(fluoromethyl)piperazin-1-yl]ethan-1-one;
1-{2-[(2R,5R)-2-(Methoxymethyl)-5-methylpiperazin-1-yl]acetyl}-3,3-dimethyl-2,3-dihydro-1H-indole-6-carbonitrile hydrochloride;
1-{6-Cyclohexyl-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl}-2-[(2R,5R)-2-(methoxymethyl)-5-methylpiperazin-1-yl]ethan-1-one dihydrochloride;
1-[6-(2,6-Dimethylphenoxy)-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl]-2-[(2R,5R)-2-(methoxymethyl)-5-methylpiperazin-1-yl]ethan-1-one hydrochloride;
1-{6′-Chloro-1,1′,2′,3-tetrahydrospiro[indene-2,3′-indole]-1′-yl}-2-[(2R,5R)-2-(methoxymethyl)-5-methylpiperazin-1-yl]ethan-1-one;
1-{6-Benzyl-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl}-2-[(2R,5R)-2-(fluoromethyl)-5-methylpiperazin-1-yl]ethan-1-one hydrochloride;
1-{6-Benzyl-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl}-2-[(2R,5R)-2-(difluoromethyl)-5-methylpiperazin-1-yl]ethan-1-one hydrochloride;
1-(6-Chloro-3-ethyl-3-methyl-2,3-dihydro-1H-indol-1-yl)-2-[(2R,5R)-2-(methoxymethyl)-5-methylpiperazin-1-yl]ethan-1-one hydrochloride;
1-[3,3-Dimethyl-6-(1-methyl-1H-pyrazol-4-yl)-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl]-2-[(2R,5R)-2-(methoxymethyl)-5-methylpiperazin-1-yl]ethan-1-one dihydrochloride;
1-[(1-{2-[(2R,5R)-2-(Methoxymethyl)-5-methylpiperazin-1-yl]acetyl}-3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)methyl]pyrrolidin-2-one hydrochloride;
1-[3,3-Dimethyl-6-(thiophen-3-yl)-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl]-2-[(2R,5R)-2-(methoxymethyl)-5-methylpiperazin-1-yl]ethan-1-one dihydrochloride;
1-[6-Bromo-3-(methoxymethyl)-3-methyl-2,3-dihydro-1H-indol-1-yl]-2-[(2R,5R)-2-(methoxymethyl)-5-methylpiperazin-1-yl]ethan-1-one hydrochloride;
1-[6-(2,6-Difluorophenoxy)-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl]-2-[(2R,5R)-2-(methoxymethyl)-5-methylpiperazin-1-yl]ethan-1-one hydrochloride;
Methyl 6-bromo-1-{2-[(2R,5R)-2-(methoxymethyl)-5-methylpiperazin-1-yl]acetyl}-3-methyl-2,3-dihydro-1H-indole-3-carboxylate hydrochloride;
1-[6-(2-Chloro-6-methylphenoxy)-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl]-2-[(2R,5R)-2-(methoxymethyl)-5-methylpiperazin-1-yl]ethan-1-one hydrochloride;
1-{6-Benzyl-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl}-2-[(2R,5R)-5-methyl-2-[(pyrrolidin-1-yl)carbonyl]piperazin-1-yl]ethan-1-one dihydrochloride;
1-{6-[Methoxy(phenyl)methyl]-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl}-2-[(2R,5R)-2-(methoxymethyl)-5-methylpiperazin-1-yl]ethan-1-one dihydrochloride;
1-{6-Benzyl-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl}-2-[(2R,5R)-5-methyl-2-[(piperidin-1-yl)carbonyl]piperazin-1-yl]ethan-1-one dihydrochloride;
1-{2-[(2R,5R)-2-(Methoxymethyl)-5-methylpiperazin-1-yl]acetyl}-3,3,5-trimethyl-2,3-dihydro-1H-indole-6-carbonitrile;
1-(6-Chloro-3,3-diethyl-2,3-dihydro-1H-indol-1-yl)-2-[(2R,5R)-5-methyl-2-[(morpholin-4-yl)carbonyl]piperazin-1-yl]ethan-1-one hydrochloride;
1-{2-[(2R,5R)-2-(Methoxymethyl)-5-methylpiperazin-1-yl]acetyl}-3-methyl-3-phenyl-2,3-dihydro-1H-indole-6-carbonitrile;
1-{6-Benzyl-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-b]pyridin-1-yl}-2-[(2R,5R)-2-(methoxymethyl)-5-methylpiperazin-1-yl]ethan-1-one hydrochloride;
1-(6-Chloro-3,3-dimethyl-2,3-dihydro-1H-indol-1-yl)-2-[(2R,5R)-5-methyl-2-(1H-pyrazol-1-ylmethyl)piperazin-1-yl]ethan-1-one hydrochloride;
(3S)-1-{2-[(2R,5R)-2-(Methoxymethyl)-5-methylpiperazin-1-yl]acetyl}-3-methyl-3-phenyl-2,3-dihydro-1H-indole-6-carbonitrile;
(3R)-1-{2-[(2R,5R)-2-(Methoxymethyl)-5-methylpiperazin-1-yl]acetyl}-3-methyl-3-phenyl-2,3-dihydro-1H-indole-6-carbonitrile;
1-[6-Chloro-3,3-dimethyl-5-(3-methyl-1,2,4-oxadiazol-5-yl)-2,3-dihydro-1H-indol-1-yl]-2-[(2R,5R)-2-(methoxymethyl)-5-methylpiperazin-1-yl]ethan-1-one;
1-{6′-Chloro-1,1′,2′,3-tetrahydrospiro[indene-2,3′-indole]-1′-yl}-2-[(2R,5R)-5-methyl-2-(1H-pyrazol-1-ylmethyl)piperazin-1-yl]ethan-1-one hydrochloride;
3-Methyl-1-{2-[(2R,5R)-5-methyl-2-(1H-pyrazol-1-ylmethyl)piperazin-1-yl]acetyl}-3-phenyl-2,3-dihydro-1H-indole-6-carbonitrile hydrochloride;
1-[6-Benzyl-3-methyl-3-(pyridin-2-yl)-2,3-dihydro-1H-indol-1-yl]-2-[(2R,5R)-2-(methoxymethyl)-5-methylpiperazin-1-yl]ethan-1-one hydrochloride;
1-[6-(Furan-3-yl)-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl]-2-[(2R,5R)-2-(methoxymethyl)-5-methylpiperazin-1-yl]ethan-1-one dihydrochloride;
1-{6-[Difluoro(phenyl)methyl]-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl}-2-[(2R,5R)-2-(methoxymethyl)-5-methylpiperazin-1-yl]ethan-1-one hydrochloride;
1-{6-Benzyl-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl}-2-[(2R,5R)-5-methyl-2-[(4-methyl-1H-pyrazol-1-yl)methyl]piperazin-1-yl]ethan-1-one hydrochloride;
1-[3,3-Dimethyl-6-(5-methylthiophen-2-yl)-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl]-2-[(2R,5R)-2-(methoxymethyl)-5-methylpiperazin-1-yl]ethan-i-one dihydrochloride;
3-Methyl-1-{2-[(2R,5R)-5-methyl-2-[(morpholin-4-yl)carbonyl]piperazin-1-yl]acetyl}-3-phenyl-2,3-dihydro-1H-indole-6-carbonitrile hydrochloride;
1-[6-(1-Benzofuran-2-yl)-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl]-2-[(2R,5R)-2-(methoxymethyl)-5-methylpiperazin-1-yl]ethan-i-one dihydrochloride;
(2R,5R)-1-{2-[6-(2-Chlorophenoxy)-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl]-2-oxoethyl}-N,N,5-trimethylpiperazine-2-carboxamide dihydrochloride;
(3S)-3-Methyl-I-{2-[(2R,5R)-5-methyl-2-[(morpholin-4-yl)carbonyl]piperazin-1-yl]acetyl}-3-phenyl-2,3-dihydro-1H-indole-6-carbonitrile;
(3R)-3-Methyl-1-{2-[(2R,5R)-5-methyl-2-[(morpholin-4-yl)carbonyl]piperazin-1-yl]acetyl}-3-phenyl-2,3-dihydro-1H-indole-6-carbonitrile;
(3S)-3-Methyl-1-{2-[(2R,5R)-5-methyl-2-(1H-pyrazol-1-ylmethyl)piperazin-1-yl]acetyl}-3-phenyl-2,3-dihydro-1H-indole-6-carbonitrile;
(3R)-3-Methyl-1-{2-[(2R,5R)-5-methyl-2-(1H-pyrazol-1-ylmethyl)piperazin-1-yl]acetyl}-3-phenyl-2,3-dihydro-1H-indole-6-carbonitrile;
1-{2-[(2R,5R)-2-(Methoxymethyl)-5-methylpiperazin-1-yl]acetyl}-3-methyl-3-(pyridin-2-yl)-2,3-dihydro-1H-indole-6-carbonitrile hydrochloride;
1-{6-Benzyl-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl}-2-[(2R,5R)-2-[(4-fluoro-1H-pyrazol-1-yl)methyl]-5-methylpiperazin-1-yl]ethan-1-one hydrochloride;
(2R,5R)-1-(2-{6-[Difluoro(phenyl)methyl]-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl}-2-oxoethyl)-N,N,5-trimethylpiperazine-2-carboxamide dihydrochloride;
1-{6-[Difluoro(phenyl)methyl]-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl}-2-[(2R,5R)-5-methyl-2-[(4-methyl-1H-pyrazol-1-yl)methyl]piperazin-1-yl]ethan-1-one dihydrochloride;
1-{6-Benzyl-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-b]pyridin-1-yl}-2-[(2R,5R)-5-methyl-2-[(morpholin-4-yl)carbonyl]piperazin-1-yl]ethan-i-one dihydrochloride;
1′-{2-[(2R,5R)-5-Methyl-2-[(4-methyl-1H-pyrazol-1-yl)methyl]piperazin-1-yl]acetyl}-1,1′,2′,3-tetrahydrospiro[indene-2,3′-indole]-6′-carbonitrile;
3,3-Dimethyl-1-{2-[(3R)-3-methylpiperazin-1-yl]acetyl}-2,3-dihydro-1H-indole-6-carbonitrile;
1-[6-Benzyl-3-methyl-3-(pyridin-3-yl)-2,3-dihydro-1H-indol-1-yl]-2-[(2R,5R)-2-(methoxymethyl)-5-methylpiperazin-1-yl]ethan-i-one hydrochloride;
(2R,5R)-1-(2-{6-[(2,4-Difluorophenyl)methyl]-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl}-2-oxoethyl)-N,N,5-trimethylpiperazine-2-carboxamide dihydrochloride;
1-[6-(2-Chlorophenoxy)-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl]-2-[(2R,5R)-5-methyl-2-[(morpholin-4-yl)carbonyl]piperazin-1-yl]ethan-i-one dihydrochloride;
6-[(2,4-Difluorophenyl)methyl]-1-{2-[(2R,5R)-2-(methoxymethyl)-5-methylpiperazin-1-yl]acetyl}-3,3-dimethyl-1H,2H,3H-1,5λ5-pyrrolo[3,2-c][1λ5]pyridin-5-one hydrochloride;
(2R,5R)-1-(2-{6-[(2,4-Difluorophenyl)methyl]-3,3-dimethyl-5-oxo-1H,2H,3H-1,55-pyrrolo[3,2-c][125]pyridin-1-yl}-2-oxoethyl)-N,N,5-trimethylpiperazine-2-carboxamide hydrochloride;
1-[(3R)-6-Bromo-3-(methoxymethyl)-3-methyl-2,3-dihydro-1H-indol-1-yl]-2-[(2R,5R)-2-(methoxymethyl)-5-methylpiperazin-1-yl]ethan-1-one hydrochloride;
1-[(3S)-6-Bromo-3-(methoxymethyl)-3-methyl-2,3-dihydro-1H-indol-1-yl]-2-[(2R,5R)-2-(methoxymethyl)-5-methylpiperazin-1-yl]ethan-1-one hydrochloride;
(2R,5R)-1-(2-{6-Benzyl-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-b]pyridin-1-yl}-2-oxoethyl)-N,N,5-trimethylpiperazine-2-carboxamide dihydrochloride;
1-{6-Benzyl-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-b]pyridin-1-yl}-2-[(2R,5R)-2-[(4-fluoro-1H-pyrazol-1-yl)methyl]-5-methylpiperazin-1-yl]ethan-1-one dihydrochloride;
1-{[(2R,5R)-1-(2-{6-Benzyl-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl}-2-oxoethyl)-5-methylpiperazin-2-yl]methyl}pyrrolidin-2-one dihydrochloride;
1-{[(2R,5R)-1-(2-{6-[Difluoro(phenyl)methyl]-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl}-2-oxoethyl)-5-methylpiperazin-2-yl]methyl}pyrrolidin-2-one dihydrochloride;
1-[(3R)-6-Benzyl-3-methyl-3-(3-methyl-1,2-oxazol-5-yl)-2,3-dihydro-1H-indol-1-yl]-2-[(2R,5R)-2-(methoxymethyl)-5-methylpiperazin-1-yl]ethan-1-one hydrochloride;
1-[(3S)-6-Benzyl-3-methyl-3-(3-methyl-1,2-oxazol-5-yl)-2,3-dihydro-1H-indol-1-yl]-2-[(2R,5R)-2-(methoxymethyl)-5-methylpiperazin-1-yl]ethan-1-one hydrochloride;
1-{6-[Difluoro(phenyl)methyl]-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl}-2-[(2R,5R)-2-[(4-fluoro-1H-pyrazol-1-yl)methyl]-5-methylpiperazin-1-yl]ethan-1-one hydrochloride;
1-[6-(2-Chlorophenoxy)-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl]-2-[(2R,5R)-2-[(4-fluoro-1H-pyrazol-1-yl)methyl]-5-methylpiperazin-1-yl]ethan-1-one hydrochloride;
1-{6-[Difluoro(phenyl)methyl]-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl}-2-[(2R,5R)-5-methyl-2-[(morpholin-4-yl)carbonyl]piperazin-1-yl]ethan-1-one dihydrochloride;
1-{[(2R,5R)-1-(2-{6-[(2,4-Difluorophenyl)methyl]-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl}-2-oxoethyl)-5-methylpiperazin-2-yl]methyl}pyrrolidin-2-one hydrochloride;
1-{[(2R,5R)-1-(2-{6-Benzyl-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-b]pyridin-1-yl}-2-oxoethyl)-5-methylpiperazin-2-yl]methyl}pyrrolidin-2-one dihydrochloride;
1-[6-(1,1-Difluoroethyl)-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl]-2-[(2R,5R)-2-(methoxymethyl)-5-methylpiperazin-1-yl]ethan-1-one dihydrochloride;
1-{[(2R,5R)-1-{2-[6-(2-Chlorophenoxy)-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl]-2-oxoethyl}-5-methylpiperazin-2-yl]methyl}pyrrolidin-2-one hydrochloride;
1-{3-Chloro-7,7-dimethyl-5H,6H,7H-pyrrolo[3,2-c]pyridazin-5-yl}-2-[(2R,5R)-2-(methoxymethyl)-5-methylpiperazin-1-yl]ethan-1-one hydrochloride;
1-{[(2R,5R)-1-{2-[6-(1,1-Difluoroethyl)-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl]-2-oxoethyl}-5-methylpiperazin-2-yl]methyl}pyrrolidin-2-one dihydrochloride;
1-{[(2R,5R)-1-(2-{6-[(2,4-Difluorophenyl)methyl]-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl}-2-oxoethyl)-5-methylpiperazin-2-yl]methyl}-1,2-dihydropyrimidin-2-one dihydrochloride;
1-[6-(1,1-Difluoropropyl)-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-b]pyridin-1-yl]-2-[(2R,5R)-5-methyl-2-{[(3R)-3-methylmorpholin-4-yl]methyl}piperazin-1-yl]ethan-1-one hydrochloride;
1-{[(2R,5R)-1-(2-{6-Benzoyl-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-b]pyridin-1-yl}-2-oxoethyl)-5-methylpiperazin-2-yl]methyl}pyrrolidin-2-one dihydrochloride;
1-{[(2R,5R)-1-{2-[6-(1,1-Difluoroethyl)-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-b]pyridin-1-yl]-2-oxoethyl}-5-methylpiperazin-2-yl]methyl}pyrrolidin-2-one dihydrochloride;
3-{[(2R,5R)-1-{2-[6-(2-Chlorophenoxy)-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl]-2-oxoethyl}-5-methylpiperazin-2-yl]methyl}-1,3-oxazolidin-2-one hydrochloride;
1-{[(2R,5R)-1-{2-[6-(1,1-Difluoropropyl)-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-b]pyridin-1-yl]-2-oxoethyl}-5-methylpiperazin-2-yl]methyl}pyrrolidin-2-one hydrochloride;
4-{[(2R,5R)-1-(2-{6-[(2,4-Difluorophenyl)methyl]-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl}-2-oxoethyl)-5-methylpiperazin-2-yl]methyl}morpholin-3-one hydrochloride;
1-{[(2R,5R)-1-(2-{6-[(2,4-Difluorophenyl)methyl]-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl}-2-oxoethyl)-5-methylpiperazin-2-yl]methyl}piperidin-2-one hydrochloride;
1-{[(2R,5R)-1-(2-{6-[(2,4-Difluorophenyl)methyl]-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl}-2-oxoethyl)-5-methylpiperazin-2-yl]methyl}-1,2-dihydropyridin-2-one dihydrochloride;
2-{[(2R,5R)-1-(2-{6-[(2,4-Difluorophenyl)methyl]-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl}-2-oxoethyl)-5-methylpiperazin-2-yl]methyl}-2,3-dihydropyridazin-3-one dihydrochloride;
1-{[(2R,5R)-1-(2-{6-[(2,4-Difluorophenyl)methyl]-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl}-2-oxoethyl)-5-methylpiperazin-2-yl]methyl}-1,2-dihydropyrazin-2-one dihydrochloride;
3,3-Dimethyl-1-[(2S)-2-[(3R)-3-methylpiperazin-1-yl]propanoyl]-2,3-dihydro-1H-indole-6-carbonitrile hydrochloride;
1-{[(2R,5R)-1-(2-{6-[Difluoro(phenyl)methyl]-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl}-2-oxoethyl)-5-methylpiperazin-2-yl]methyl}-3-methylimidazolidin-2-one hydrochloride;
1-{[(2R,5R)-1-{2-[6-(1,1-Difluoropropyl)-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl]-2-oxoethyl}-5-methylpiperazin-2-yl]methyl}pyrrolidin-2-one;
1-{[(2R,5R)-1-(2-{6-[(2,4-Difluorophenyl)methyl]-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-b]pyridin-1-yl}-2-oxoethyl)-5-methylpiperazin-2-yl]methyl}pyrrolidin-2-one dihydrochloride;
3-{[(2R,5R)-1-(2-{6-[(2,4-Difluorophenyl)methyl]-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-b]pyridin-1-yl}-2-oxoethyl)-5-methylpiperazin-2-yl]methyl}-1,3-oxazolidin-2-one dihydrochloride;
1-{[(2R,5R)-1-(2-{3-[(2,4-Difluorophenyl)methyl]-7,7-dimethyl-5H,6H,7H-pyrrolo[3,2-c]pyridazin-5-yl}-2-oxoethyl)-5-methylpiperazin-2-yl]methyl}pyrrolidin-2-one hydrochloride;
1-{6-[(2,4-Difluorophenyl)methyl]-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl}-2-[(2R,5R)-2-{[(3S)-3-fluoropyrrolidin-1-yl]methyl}-5-methylpiperazin-1-yl]ethan-1-one dihydrochloride;
1-{6-[(2,4-Difluorophenyl)methyl]-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl}-2-[(2R,5R)-2-{[(3R)-3-fluoropyrrolidin-1-yl]methyl}-5-methylpiperazin-1-yl]ethan-1-one dihydrochloride;
1-{6-[(2,4-Difluorophenyl)methyl]-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-b]pyridin-1-yl}-2-[(2R,5R)-2-{[(3S)-3-fluoropyrrolidin-1-yl]methyl}-5-methylpiperazin-1-yl]ethan-1-one dihydrochloride;
1-{6-[(2,4-Difluorophenyl)methyl]-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-b]pyridin-1-yl}-2-[(2R,5R)-2-{[(3R)-3-fluoropyrrolidin-1-yl]methyl}-5-methylpiperazin-1-yl]ethan-1-one hydrochloride;
1-{6-[(2,4-Difluorophenyl)methyl]-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl}-2-[(2R,5R)-2-[(dimethyl-1H-1,2,4-triazol-1-yl)methyl]-5-methylpiperazin-1-yl]ethan-1-one hydrochloride;
1-{[(2R,5R)-1-(2-{6-[(2,4-Difluorophenyl)methyl]-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl}-2-oxoethyl)-5-methylpiperazin-2-yl]methyl}pyrrolidin-3-one dihydrochloride;
1-{6-[(2,4-Difluorophenyl)methyl]-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl}-2-[(2R,5R)-2-[(3,3-difluoropyrrolidin-1-yl)methyl]-5-methylpiperazin-1-yl]ethan-1-one dihydrochloride;
3-{[(2R,5R)-1-(2-{6-[(2,4-Difluorophenyl)methyl]-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl}-2-oxoethyl)-5-methylpiperazin-2-yl]methyl}-1,3-oxazolidin-2-one dihydrochloride;
1-{[(2R,5R)-1-(2-{6-[Difluoro(phenyl)methyl]-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-b]pyridin-1-yl}-2-oxoethyl)-5-methylpiperazin-2-yl]methyl}pyrrolidin-2-one hydrochloride;
1-{[(2R,5R)-1-{2-[6-(1,1-Difluoro-2-methylpropyl)-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl]-2-oxoethyl}-5-methylpiperazin-2-yl]methyl}pyrrolidin-2-one hydrochloride;
1-{[(2R,5R)-1-{2-[6-(Cyclopropyldifluoromethyl)-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl]-2-oxoethyl}-5-methylpiperazin-2-yl]methyl}pyrrolidin-2-one hydrochloride;
1-{6-[Difluoro(phenyl)methyl]-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl}-2-[(2R,5R)-2-{[(3R)-3-fluoropyrrolidin-1-yl]methyl}-5-methylpiperazin-1-yl]ethan-1-one dihydrochloride;
1-[6-(1,1-Difluoropropyl)-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl]-2-[(2R,5R)-2-{[(3R)-3-fluoropyrrolidin-1-yl]methyl}-5-methylpiperazin-1-yl]ethan-1-one hydrochloride;
1-{[(2R,5R)-1-(2-{6-[(4-Fluorophenyl)methyl]-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-b]pyridin-1-yl}-2-oxoethyl)-5-methylpiperazin-2-yl]methyl}pyrrolidin-2-one dihydrochloride;
1-{[(2R,5R)-1-{2-[6-(1,1-Difluoro-3-methylbutyl)-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-b]pyridin-1-yl]-2-oxoethyl}-5-methylpiperazin-2-yl]methyl}pyrrolidin-2-one dihydrochloride;
1-{[(2R,5R)-1-{2-[6-(1,1-Difluorobutyl)-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-b]pyridin-1-yl]-2-oxoethyl}-5-methylpiperazin-2-yl]methyl}pyrrolidin-2-one hydrochloride;
1-{[(2R,5R)-1-(2-{6-[Difluoro(phenyl)methyl]-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl}-2-oxoethyl)-5-methylpiperazin-2-yl]methyl}pyrrolidine-2,5-dione dihydrochloride;
1-{6-[(2,4-Difluorophenyl)methyl]-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl}-2-[(2R,5R)-5-methyl-2-(morpholin-4-ylmethyl)piperazin-1-yl]ethan-1-one dihydrochloride;
1-{6-[(2,4-Difluorophenyl)methyl]-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl}-2-[(2R,5R)-5-methyl-2-(pyrrolidin-1-ylmethyl)piperazin-1-yl]ethan-1-one dihydrochloride;
1-{6-[Difluoro(phenyl)methyl]-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-b]pyridin-1-yl}-2-[(2R,5R)-2-{[(3R)-3-fluoropyrrolidin-1-yl]methyl}-5-methylpiperazin-1-yl]ethan-1-one dihydrochloride;
1-[6-(1,1-Difluoroethyl)-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-b]pyridin-1-yl]-2-[(2R,5R)-5-methyl-2-{1H,2H,3H-pyrrolo[2,3-b]pyridin-1-ylmethyl}piperazin-1-yl]ethan-1-one dihydrochloride;
1-[6-(1,1-Difluorobutyl)-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-b]pyridin-1-yl]-2-[(2R,5R)-2-{[(3R)-3-fluoropyrrolidin-1-yl]methyl}-5-methylpiperazin-1-yl]ethan-1-one hydrochloride;
1-{6-[Difluoro(phenyl)methyl]-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl}-2-[(2R,5R)-5-methyl-2-(morpholin-4-ylmethyl)piperazin-1-yl]ethan-1-one dihydrochloride;
1-{[(2R,5R)-1-{2-[6-(1,1-Difluoro-3-methylbutyl)-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl]-2-oxoethyl}-5-methylpiperazin-2-yl]methyl}pyrrolidin-2-one hydrochloride;
1-{[(2R,5R)-1-{2-[6-(Cyclobutyldifluoromethyl)-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-b]pyridin-1-yl]-2-oxoethyl}-5-methylpiperazin-2-yl]methyl}pyrrolidin-2-one dihydrochloride;
1-{[(2R,5R)-1-{2-[6-(1,1-Difluorobutyl)-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl]-2-oxoethyl}-5-methylpiperazin-2-yl]methyl}pyrrolidin-2-one hydrochloride;
4-{[(2R,5R)-1-{2-[6-(1,1-Difluoroethyl)-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-b]pyridin-1-yl]-2-oxoethyl}-5-methylpiperazin-2-yl]methyl}-1-methylpiperazin-2-one dihydrochloride;
1-[6-(1,1-Difluoro-3-methylbutyl)-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl]-2-[(2R,5R)-5-methyl-2-(morpholin-4-ylmethyl)piperazin-1-yl]ethan-1-one hydrochloride;
1-{[(2R,5R)-1-{2-[6-(2-Cyclopropyl-1,1-difluoroethyl)-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-b]pyridin-1-yl]-2-oxoethyl}-5-methylpiperazin-2-yl]methyl}pyrrolidin-2-one formate;
1-[6-(2-Cyclopropyl-1,1-difluoroethyl)-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-b]pyridin-1-yl]-2-[(2R,5R)-5-methyl-2-(morpholin-4-ylmethyl)piperazin-1-yl]ethan-1-one dihydrochloride;
1-{6-[Difluoro(phenyl)methyl]-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-b]pyridin-1-yl}-2-[(2R,5R)-5-methyl-2-(morpholin-4-ylmethyl)piperazin-1-yl]ethan-1-one dihydrochloride;
1-[6-(1,1-Difluorobutyl)-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl]-2-[(2S,5R)-5-methyl-2-(1,3-thiazol-2-ylmethyl)piperazin-1-yl]ethan-1-one hydrochloride;
1-{6-[(4-Fluorophenyl)methyl]-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-b]pyridin-1-yl}-2-[(2R,5R)-5-methyl-2-(morpholin-4-ylmethyl)piperazin-1-yl]ethan-1-one dihydrochloride;
1-[6-(1,1-Difluoro-3-methylbutyl)-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-b]pyridin-1-yl]-2-[(2R,5R)-5-methyl-2-(morpholin-4-ylmethyl)piperazin-1-yl]ethan-1-one;
1-{6-[(2,4-Difluorophenyl)methyl]-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-b]pyridin-1-yl}-2-[(2R,5R)-5-methyl-2-(morpholin-4-ylmethyl)piperazin-1-yl]ethan-1-one dihydrochloride;
1-{6-[(4-Fluorophenyl)methyl]-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl}-2-[(2R,5R)-5-methyl-2-(morpholin-4-ylmethyl)piperazin-1-yl]ethan-1-one hydrochloride;
1-[6-(1,1-Difluorobutyl)-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-b]pyridin-1-yl]-2-[(2R,5R)-5-methyl-2-(morpholin-4-ylmethyl)piperazin-1-yl]ethan-1-one hydrochloride;
1-[6-(1,1-Difluorobutyl)-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl]-2-[(2R,5R)-5-methyl-2-(morpholin-4-ylmethyl)piperazin-1-yl]ethan-1-one hydrochloride;
1-{6-[(4-Fluorophenyl)methyl]-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-b]pyridin-1-yl}-2-[(2R,5R)-5-methyl-2-{[(3S)-3-methylmorpholin-4-yl]methyl}piperazin-1-yl]ethan-1-one dihydrochloride;
1-{6-[(4-Fluorophenyl)methyl]-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-b]pyridin-1-yl}-2-[(2R,5R)-2-{[(3R)-3-fluoropyrrolidin-1-yl]methyl}-5-methylpiperazin-1-yl]ethan-1-one dihydrochloride;
1-{[(2R,5R)-1-(2-{6-[(2-Fluorophenyl)methyl]-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl}-2-oxoethyl)-5-methylpiperazin-2-yl]methyl}pyrrolidin-2-one hydrochloride;
2-[(2R,5R)-2-{[(2R,6S)-2,6-Dimethylmorpholin-4-yl]methyl}-5-methylpiperazin-1-yl]-1-{6-[(4-fluorophenyl)methyl]-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-b]pyridin-1-yl}ethan-1-one dihydrochloride;
1-{6-[(2-Fluorophenyl)methyl]-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl}-2-[(2R,5R)-5-methyl-2-{[(3R)-3-methylmorpholin-4-yl]methyl}piperazin-1-yl]ethan-1-one hydrochloride;
1-{6-[(2-Fluorophenyl)methyl]-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl}-2-[(2R,5R)-5-methyl-2-(morpholin-4-ylmethyl)piperazin-1-yl]ethan-1-one hydrochloride;
1-[6-(1,1-Difluorobutyl)-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-b]pyridin-1-yl]-2-[(2R,5R)-2-{[(2R,6S)-2,6-dimethylmorpholin-4-yl]methyl}-5-methylpiperazin-1-yl]ethan-1-one dihydrochloride;
1-{6-[(2-Fluorophenyl)methyl]-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-b]pyridin-1-yl}-2-[(2R,5R)-5-methyl-2-(morpholin-4-ylmethyl)piperazin-1-yl]ethan-1-one dihydrochloride;
1-[6-(1,1-Difluorobutyl)-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-b]pyridin-1-yl]-2-[(2R,5R)-2-{[(3R)-3-ethylmorpholin-4-yl]methyl}-5-methylpiperazin-1-yl]ethan-1-one dihydrochloride;
1-{[(2R,5R)-1-(2-{6-[(2-Fluorophenyl)methyl]-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-b]pyridin-1-yl}-2-oxoethyl)-5-methylpiperazin-2-yl]methyl}pyrrolidin-2-one hydrochloride;
1-{6-[(2-Fluorophenyl)methyl]-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-b]pyridin-1-yl}-2-[(2R,5R)-2-{[(3R)-3-fluoropyrrolidin-1-yl]methyl}-5-methylpiperazin-1-yl]ethan-1-one dihydrochloride;
1-{6-[(4-Fluorophenyl)methyl]-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl}-2-[(2R,5R)-5-methyl-2-{[(3R)-3-methylmorpholin-4-yl]methyl}piperazin-1-yl]ethan-1-one dihydrochloride;
1-[6-(1,1-Difluorobutyl)-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-1-yl]-2-[(2R,5R)-5-methyl-2-{[(3R)-3-methylmorpholin-4-yl]methyl}piperazin-1-yl]ethan-1-one dihydrochloride;
1-[6-(1,1-Difluoroethyl)-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-b]pyridin-1-yl]-2-[(2R,5R)-2-{[(3R)-3-ethylmorpholin-4-yl]methyl}-5-methylpiperazin-1-yl]ethan-1-one dihydrochloride;
2-[(2R,5R)-2-{[(3R)-3-Ethylmorpholin-4-yl]methyl}-5-methylpiperazin-1-yl]-1-{6-[(4-fluorophenyl)methyl]-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-b]pyridin-1-yl}ethan-1-one dihydrochloride;
1-[6-(1,1-Difluoropropyl)-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-b]pyridin-1-yl]-2-[(2R,5R)-2-{[(3R)-3-ethylmorpholin-4-yl]methyl}-5-methylpiperazin-1-yl]ethan-1-one dihydrochloride;
1-[6-(1,1-Difluoropropyl)-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-b]pyridin-1-yl]-2-[(2R,5R)-2-{[(3R)-3-(methoxymethyl)morpholin-4-yl]methyl}-5-methylpiperazin-1-yl]ethan-1-one dihydrochloride;
1-(6-Benzyl-3,3-dimethyl-2,3-dihydro-pyrrolo[2,3-b]pyridin-1-yl)-2-((2R,5R)-2-methoxymethyl-5-methyl-piperazin-1-yl)-ethanone hydrochloride;
1-[3,3-Dimethyl-6-(1H-tetrazol-5-yl)-2,3-dihydro-indol-1-yl]-2-((2R,5R)-2-methoxymethyl-5-methyl-piperazin-1-yl)-ethanone hydrochloride;
1-[6-(4-Fluoro-benzyl)-3,3-dimethyl-2,3-dihydro-pyrrolo[3,2-b]pyridin-1-yl]-2-[(2R,5R)-5-methyl-2-((R)-3-methyl-morpholin-4-ylmethyl)-piperazin-1-yl]-ethanone dihydrochloride;
1-[6-(1,1-Difluoro-butyl)-3,3-dimethyl-2,3-dihydro-pyrrolo[3,2-b]pyridin-1-yl]-2-[(2R,5R)-5-methyl-2-((R)-3-methyl-morpholin-4-ylmethyl)-piperazin-1-yl]-ethanone dihydrochloride;
1-[6-(2-Fluoro-benzyl)-3,3-dimethyl-2,3-dihydro-pyrrolo[3,2-b]pyridin-1-yl]-2-[(2R,5R)-5-methyl-2-((R)-3-methyl-morpholin-4-ylmethyl)-piperazin-1-yl]-ethanone dihydrochloride;
1-[6-(4-Fluoro-benzyl)-3,3-dimethyl-2,3-dihydro-pyrrolo[3,2-b]pyridin-1-yl]-2-[(2R,5R)-5-methyl-2-((R)-3-methyl-morpholin-4-ylmethyl)-piperazin-1-yl]-ethanone;
1-[6-(4-Fluoro-benzyl)-3,3-dimethyl-2,3-dihydro-pyrrolo[3,2-b]pyridin-1-yl]-2-[(2R,5R)-5-methyl-2-((R)-3-methyl-morpholin-4-ylmethyl)-piperazin-1-yl]-ethanone hydrochloride;
1-[6-(2,4-Difluoro-benzyl)-3,3-dimethyl-2,3-dihydro-pyrrolo[3,2-b]pyridin-1-yl]-2-[(2R,5R)-5-methyl-2-((R)-3-methyl-morpholin-4-ylmethyl)-piperazin-1-yl]-ethanone, dihydrochloride;
1-[6-(4-Fluoro-benzyl)-3,3-dimethyl-2,3-dihydro-pyrrolo[3,2-b]pyridin-1-yl]-2-((R)-3-methyl-piperazin-1-yl)-ethanone; and
3,3-Dimethyl-1-[(2S)-2-[(3R)-3-methylpiperazin-1-yl]butanoyl]-2,3-dihydro-1H-indole-6-carbonitrile, hydrochloride salt;
or a tautomeric or stereochemically isomeric form, N-oxide, pharmaceutically acceptable salt or the solvate thereof.