Patent ID: 11914034
Assignee: WASHINGTON UNIVERSITY
Field: Medical technology (Instruments)
Classification: CPC A  G | IPC A  G

Claim 0:
1. A diffuse optical tomography (DOT) system for generating a functional image of a lesion region of a subject, comprising:
a source subsystem configured to generate optical waves;
a probe coupled to the source subsystem and configured to emit the optical waves generated by the source subsystem toward the lesion region and to detect optical waves reflected by the lesion region;
a detection subsystem configured to convert the optical waves detected by the probe to digital signals; and
a computing device including a processor and a memory, the memory including instructions that program the processor to:
receive the digital signals sent from the detection subsystem; and
generate a 3D target shape from a plurality of co-registered ultrasound images using a semi-automated interactive convolutional neural network (CNN);
generate a regularization matrix from the 3D target shape; and
perform reconstruction for the digital signals using a depth-regularized reconstruction algorithm for depth-dependent reconstruction of absorption distribution in which reconstruction is constrained by the regularization matrix.