Patent ID: 11925631
Assignee: GILEAD SCIENCES, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 8:
9. The method of claim 1, wherein the compound is of Formula III,, , or a pharmaceutically acceptable salt thereof,, wherein:
one of R1 and R2 is —OH or C1-3 alkyl, and the other of R1 and R2 is C1-3 alkyl, or
R1 and R2 together with the carbon to which they are attached form a 4-6 membered monocyclic heterocyclyl having 1 or 2 heteroatoms independently selected from N, O, and S, wherein the 4-6 membered monocyclic heterocyclyl is optionally substituted with one R11 and optionally substituted with 1-3 groups independently selected from —OH, halogen, oxo, C1-3 alkyl, and C1-3 alkoxy;
R11 is
i) 4-6 membered monocyclic heterocyclyl having 1 or 2 heteroatoms independently selected from N, O, and S, wherein the 4-6 membered monocyclic heterocyclyl is optionally substituted with 1-3 groups independently selected from —CN, —OH, halogen, oxo, C1-3 alkyl, and C1-3 alkoxy, or
ii) —C(O)R21;

R21 is
i) C3-7 monocyclic or bridged bicyclic cycloalkyl optionally substituted with 1-3 groups independently selected from —CN, —OH, halogen, C1-3 alkyl, and C1-3 alkoxy, wherein the C1-3 alkyl is optionally substituted with 1-3 groups independently selected from —OH, halogen, and C1-3 alkoxy,
ii) 4-6 membered monocyclic heterocyclyl having 1 or 2 heteroatoms independently selected from N, O, and S, wherein the 4-6 membered monocyclic heterocyclyl is optionally substituted with 1-3 groups independently selected from —CN, —OH, halogen, oxo, C1-3 alkyl, and C1-3 alkoxy,
iii) 5-6 membered monocyclic heteroaryl having 1-4 heteroatoms independently selected from N, O, and S, wherein the 5-6 membered monocyclic heteroaryl is optionally substituted with 1-3 groups independently selected from —CN, —OH, halogen, C1-3 alkyl, and C1-3 alkoxy, or
iv) C1-6 alkoxy optionally substituted with 1-3 groups independently selected from —OH, halogen, C1-3 alkyl, and C3-7 monocyclic cycloalkyl,
v) C1-6 alkyl optionally substituted with 1-3 groups independently selected from
a) —CN,
b) —OH,
c) halogen,
d) C1-3 alkoxy, and
e) 4-6 membered monocyclic heterocyclyl having 1 or 2 heteroatoms independently selected from N, O, and S, wherein the 4-6 membered monocyclic heterocyclyl is optionally substituted with 1-3 groups independently selected from —CN, —OH, halogen, oxo, C1-3 alkyl, and C1-3 alkoxy;

X is —NR15R16, wherein R15 and R16 are independently
i) H, or
ii) C1-6 alkyl optionally substituted with 1-6 groups independently selected from
a) —OH,
b) halogen, and
c) C1-3 alkoxy; or

X is a 4-10 membered monocyclic, fused bicyclic, bridged bicyclic, or spirocyclic heterocyclyl having 1-3 heteroatoms independently selected from N, O, and S, wherein the 4-10 membered monocyclic, fused bicyclic, bridged bicyclic, or spirocyclic heterocyclyl is optionally substituted with 1-5 R18;
each R18 is independently
i) a halogen,
ii) —OH, or
iii) C1-6 alkyl optionally substituted with 1-3 groups independently selected from —OH, halogen, C1-3 alkoxy, and C3-7 monocyclic cycloalkyl;

R7 is C1-6 alkyl optionally substituted with 1-3 groups independently selected from —OH, halogen, C1-3 alkoxy, and C3-7 monocyclic cycloalkyl;
A is a pyridinyl, pyridonyl, or isoquinolinyl, each of which is optionally substituted with 1-4 R9;
each R9 is independently
i) a halogen,
ii) C1-6 alkoxy optionally substituted with 1-3 groups independently selected from —OH, halogen, C1-3 alkyl, and C3-7 monocyclic cycloalkyl,
iii) —NH2,
iv) —NH(C1-3 alkyl), wherein the C1-3 alkyl is optionally substituted with 1-3 groups independently selected from —OH, halogen, and C1-3 alkoxy,
v) —N(C1-3 alkyl)2, wherein each C1-3 alkyl can be the same or different, and wherein each C1-3 alkyl is optionally substituted with 1-3 groups independently selected from —OH, halogen, and C1-3 alkoxy,
vi) C1-6 alkyl optionally substituted with 1-3 groups independently selected from —OH, halogen, C1-3 alkoxy, and C3-7 monocyclic cycloalkyl, or vii) —C(O)N(R19)2; and

each R19 is independently
i) H,
ii) C1-6 alkyl optionally substituted with 1-6 groups independently selected from —CN, —OH, halogen, C1-3 alkoxy, and C3-7 monocyclic cycloalkyl, or
iii) C3-7 monocyclic cycloalkyl optionally substituted with 1-6 groups independently selected from —CN, —OH, halogen, C1-3 alkyl, and C1-3 alkoxy, wherein the C1-3 alkyl is optionally substituted with 1-3 groups independently selected from —CN, —OH, halogen, and C1-3 alkoxy.