Patent ID: 11905332
Assignee: REGENERON PHARMACEUTICALS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 16:
17. An isolated bispecific antigen-binding molecule, comprising:
(a) a first antigen-binding domain that specifically binds human CD38 and that comprises an HCDR1 amino acid sequence of SEQ ID NO: 4, an HCDR2 amino acid sequence of SEQ ID NO: 6, and an HCDR3 amino acid sequence of SEQ ID NO: 8;
(b) a second antigen binding domain that specifically binds human CD28 and that comprises an HCDR1 amino acid sequence of SEQ ID NO: 12, an HCDR2 amino acid sequence of SEQ ID NO: 14, and an HCDR3 amino acid sequence of SEQ ID NO: 16; and
(c) an LCVR comprising an LCDR1 amino acid sequence of SEQ ID NO: 20, an LCDR2 amino acid sequence of SEQ ID NO: 22, and an LCDR3 amino acid sequence of SEQ ID NO: 24.