Patent ID: 11938322
Assignee: SRI INTERNATIONAL
Field: Medical technology (Instruments)
Classification: CPC A | IPC A

Claim 16:
17. An apparatus including:
sensor circuitry having at least two bio-sensors configured and arranged to obtain a plurality of bio-signals, which include peripheral nervous system (PNS) bio-signals and signals indicative of sleep stages, from a user and to provide output signals indicative of the plurality of bio-signals to processing circuitry, wherein each of the PNS bio-signals are selected from the group consisting of: blood pressure, heart rate, breathing, a pulse wave, and a combination thereof;
the processing circuitry configured and arranged to:
classify a plurality of sleep stages using the signals indicative of the sleep stages using the plurality of bio-signals;
calculate a power spectral density (PSD) for each of the PNS bio-signals, the PSD for each of the PNS bio-signals being indicative of oscillations in the PNS bio-signals;
determine peaks in the PSD for each of the PNS bio-signals;
determine dominant oscillations associated with each of the PNS bio-signals based on the peaks in the PSD for each of the PNS bio-signals as a function of the sleep stages and time, wherein each of the dominant oscillations is a rhythm of the respective PNS bio-signal that occurs at a respective dominant frequency, and the respective dominant frequency includes a frequency of the PSD at the respective peak;
characterize properties of the dominant oscillations including an amplitude, phase, and frequency of the dominant oscillations by:
decomposing each of the PNS bio-signals in the respective dominant frequency as functions of time using filters to filter out frequency content other than the respective dominant frequency for each of the PNS bio-signals and identifying the properties from the decomposed PNS bio-signals; and

determine optimal windows based on timings of the properties as characterized from the decomposed PNS bio-signals, the properties including at least the phase of the dominant oscillations, for maximizing SWA generation via stimulation, wherein the optimal windows are determined based on data indicating stimulation provided to the user improves electroencephalogram (EEG) SWA within the user during the optimal windows, the data comprising past observed responses to prior stimulation including measures of EEG and the PNS signals;

stimulation circuitry configured and arranged to deliver the stimulation to the user within an optimal window of the optimal windows for maximizing EEG SWA generation; and
feedback circuitry configured and arranged to provide a feedback signal to the processing circuitry, the feedback signal being indicative of a user response to the stimulation based on an EEG signal of the user and the processing circuitry is further configured and arranged to adjust the optimized windows based on the user response to the stimulation and as indicated in the feedback signal.