Patent ID: 11926652
Assignee: THOMAS JEFFERSON UNIVERSITY AND HEALTH SYSTEM, INNOVATION PILLAR
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A recombinant CTLA-4 binding protein comprising:
(i) a CTLA-4 binding domain;
(ii) a CTLA-4 binding domain masking peptide; and
(iii) a cleavable peptide linker connecting said CTLA-4 binding domain masking peptide to said CTLA-4 binding domain;
wherein said CTLA-4 binding domain comprises a CTLA-4 binding lipocalin 2 (LCN2) comprising the amino acid sequence of SEQ ID NO: 34; and
wherein said CTLA-4 binding domain masking peptide comprises a sequence at least 90% identical to the sequence of SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12, SEQ ID NO:13 or SEQ ID NO:14.