Patent ID: 11913043
Assignee: RESEARCH DEVELOPMENT FOUNDATION
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A cell-targeted cytotoxic construct comprising:
(a) a targeting moiety that is an R-spondin targeting ligand that comprises two-tandem furin-like cysteine-rich (Fu-CRD) R-spondin domains, wherein the R-spondin targeting polypeptide ligand binds to a cell surface human LGR 4, LGR 5 and/or LGR 6 receptors;
(b) a linking polypeptide that comprises a sortase recognition site, the linking polypeptide being positioned between the targeting moiety and the cytotoxic moiety; and
(c) a cytotoxic moiety that comprises a toxin or chemotherapeutic, wherein the linking polypeptide is positioned between the targeting moiety and the cytotoxic moiety, and wherein the linking polypeptide comprises LPETG (SEQ ID NO: 66).