Patent ID: 11859185
Assignee: ALNYLAM PHARMACEUTICALS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A double stranded ribonucleic acid (RNAi) agent for inhibiting expression of a glucokinase (GCK) gene,
wherein said double stranded RNAi agent comprises a sense strand and an antisense strand forming a double stranded region,
wherein said antisense strand comprises at least 20 contiguous nucleotides differing by no more than 3 nucleotides from the complement of nucleotides 1466-1492 of the nucleotide sequence of SEQ ID NO:1,
wherein all of the nucleotides of said sense strand and all of the nucleotides of said antisense strand comprise a nucleotide modification, and
wherein said sense strand is conjugated to a ligand attached at the 3′-terminus.