Patent ID: 11896644
Assignee: UNIVERSITY OF SOUTH FLORIDA
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A

Claim 0:
1. A method of treating a tauopathy in a subject, the method comprising administering to the human subject a therapeutically effective amount of a β-arrestin oligomerization inhibitor, wherein the inhibitor is a compound having a structure or a pharmaceutically-acceptable salt thereof selected from the group consisting of:, wherein R1 is hydrogen or an alkyl group;
wherein Ar is an aryl group; and
wherein when R1 is an alkyl group, the stereochemistry at Ca is racemic, substantially R, or substantially S;, wherein Ar is an aryl group;, wherein R2 and R3 are, independently, hydrogen or an alkyl group; and Ar is an aryl group;, wherein Ar1 and Ar2 are, independently, an aryl group; and
wherein X is CH2 or C═O;, wherein Ar1 and Ar2 are, independently, an aryl group; and,