Patent ID: 11897887
Assignee: TISENTO THERAPEUTICS INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A  Y | IPC A  C

Claim 0:
1. A compound of Formula I, or a pharmaceutically acceptable salt thereof,, wherein:
Y is independently N or C;
ring B is a phenyl or a 5 or 6-membered heteroaryl ring, containing 1 or 2 ring heteroatoms independently selected from N, O and S;
n is an integer selected from 0 to 3; and each JB is independently halogen, —CN, a C1-6 aliphatic or —ORB;
wherein each JB that is a C1-6 aliphatic is optionally and independently substituted with up to 3 instances of R3;
each RB is independently hydrogen or a C1-6 aliphatic; said C1-6 aliphatic represented by RB is optionally and independently substituted with up to 3 instances of R3a;
each R3 and R3a is, in each instance, independently halogen, —CN, C1-4 alkyl, C1-4 haloalkyl, —O(C1-4 alkyl) or —O(C1-4 haloalkyl);
Z is selected from the group consisting of hydrogen, —P(O)(OH)2, —P(O)(OH)O−M+, —P(O)(O−)2 (M+)2, —P(O)(O−)2 D2+and —P(O)(O-Benzyl)2; wherein M+ is a pharmaceutically acceptable monovalent cation and D2+is a pharmaceutically acceptable divalent cation;
m is 0 or 1;
R1 is C1-4 alkyl, C1-4 fluoroalkyl, —C(O)NH2 or hydrogen; and
R2 is C1-4 alkyl, C1-4 fluoroalkyl or hydrogen;
both instances of R4 are simultaneously hydrogen or both instances of R4, together with the carbon atom to which they are attached form a carbonyl group;
JD is hydrogen, halogen, methoxy or —CN
p is 1 or 2; and
each JC is independently hydrogen, halogen, C1-4 aliphatic, C1-4 alkoxy or —CN; wherein each said C1-4 aliphatic and each said C1-4 alkoxy is optionally and independently substituted by up to 3 instances of C1-4 alkoxy, C1-4 haloalkoxy, —OH or halogen.