Patent ID: 11866697
Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A  Y | IPC A  C

Claim 7:
8. The method of claim 1, wherein said adenosine deaminase protein or catalytic domain thereof
is a human, squid or Drosophila adenosine deaminase protein or catalytic domain thereof;
has been modified to increase activity against a DNA-RNA heteroduplex;
is a mutated hADAR2d comprising mutation E488Q or a mutated hADAR1d comprising mutation E1008Q;
has been modified to reduce off-target effects; or
is a mutated hADAR2d comprising mutation T375G/S, N473D, or both, or a mutated hADAR1d comprising corresponding mutations.