Patent ID: 11905539
Assignee: CJ CHEILJEDANG CORPORATION
Field: Biotechnology (Chemistry)
Classification: CPC C | IPC C

Claim 0:
1. A modified microorganism belonging to the genus of Corynebacterium for producing L-leucine, comprising a modified polypeptide having an isopropylmalate synthase activity,
wherein glycine at position 561 from a N-terminus of a polypeptide consisting of the amino acid sequence of SEQ ID NO: 1 is substituted with aspartic acid in the modified polypeptide, and
wherein the modified microorganism has a resistance to norleucine or L-leucine, and
wherein a native promoter of a polynucleotide encoding the modified polypeptide in the microorganism is substituted with a promoter which enhances an expression of the polynucleotide compared to the native promoter.