Patent ID: 11885811
Assignee: REGENERON PHARMACEUTICALS, INC.
Field: Measurement (Instruments)
Classification: CPC G  B  H | IPC G  H

Claim 0:
1. A method for determining glycosylation profiles for at least one peptide or protein in a sample, comprising:
contacting the sample to a solid surface, wherein the solid surface comprises a hydrophobic group and the solid surface is included in a chromatography column;
washing the solid surface using a mobile phase to produce at least one eluent, wherein the eluent comprises the at least one peptide or protein;
determining the glycosylation profile of the at least one peptide or protein using a mass spectrometer; and
determining the O-glycosylation variants in the sample;
wherein the mass spectrometer is coupled online to the chromatography column.