Patent ID: 11884741
Assignee: SYSMEX CORPORATION
Field: Biotechnology (Chemistry)
Classification: CPC C | IPC C

Claim 9:
10. A method for producing a modified antibody, comprising:
in a heavy chain of the antibody, changing at least one amino acid residue selected from the group consisting of 8th to 11th amino acid residues based on Kabat method to a cysteine residue, and changing at least one amino acid residue selected from the group consisting of 109th and 110th amino acid residues based on IMGT method to a cysteine residue;
wherein a disulfide bond is formed between the cysteine residue at any position of 8 to 11 based on the Kabat method and the cysteine residue at any position of 109 and 110 based on the IMGT method;
wherein the modified antibody is Fab, Fab′, F(ab′)2, reduced IgG, IgG, IgA, IgM, IgD or IgE, and
recovering the modified antibody.