Patent ID: 11911407
Assignee: UNIVERSITY COLLEGE, DUBLIN, NATIONAL UNIVERSITY OF IRELEAND, DUBLIN
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C  G | IPC A  C  G

Claim 10:
11. A method of treating or preventing the development of cardiac hypertrophy or myocardial fibrosis or treating cardiac hypertrophy or myocardial fibrosis comprising the step of administering to a patient in need thereof an agent capable of reducing the expression of, silencing or degrading hypoxia-inducible factor (HIF) protein or HIF mRNA, or an agent capable of preventing HIF protein from binding to hypoxia responsive elements within the promoter regions of DNA methyltransferase genes, wherein the agent is an oligonucleotide of sequence SEQ ID 31 or a pharmaceutically acceptable salt thereof.