Patent ID: 11896737
Assignee: GALDERMA HOLDING SA
Field: Medical technology (Instruments)
Classification: CPC A  C | IPC A  C

Claim 0:
1. A method of producing an injectable gel product, comprising:
(a) cross-linking a first glycosaminoglycan (GAG) with a first crosslinking agent at a first charging ratio of crosslinking agent to disaccharide unit below 0.15 to produce a gel;
(b) preparing particles of the gel;
(c) mixing the GAG gel particles with a second GAG to provide a mixture;
(d) cross-linking the second GAG with a second crosslinking agent to obtain a gel having a first, inner phase of the cross-linked GAG gel particles embedded in a second, outer phase comprising the second GAG, and
(e) preparing injectable particles of the gel from (d), each such particle containing a plurality of the cross-linked GAG gel particles of the first, inner phase;
wherein the inner phase, the outer phase, or both the inner phase and the outer phase are crosslinked via one or more polyfunctional cross-linking agent selected from 1,4-butanediol diglycidyl ether (BDDE), 1,2-ethanediol diglycidyl ether (EDDE) and diepoxyoctane.