Patent ID: 11918571
Assignee: PRAXIS PRECISION MEDICINES, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A

Claim 0:
1. A method of treating a neurological disorder, wherein the neurological disorder is epilepsy or an epilepsy syndrome, wherein the method comprises administering to a subject in need thereof a compound of Formula (I):, or a pharmaceutically acceptable salt thereof, wherein:
each of X, Y, and Z is CR′;
A is phenyl or pyridyl, wherein the phenyl and the pyridyl are substituted with one or more R3;
R′ is hydrogen or C1-6 alkyl;
R1 is selected from the group consisting of hydrogen, deuterium and C1-6 alkyl, wherein the C1-6 alkyl is optionally substituted with one or more R4;
each R3 is independently selected from the group consisting of C1-6 alkyl, C3-8 carbocyclyl, fluoro, chloro and —ORc, wherein the C1-6 alkyl and C3-8 carbocyclyl are optionally substituted with one or more R5;
each of R4 is independently selected from the group consisting of deuterium, fluoro, oxo, cyano, nitro and —ORc;
each of R5 is independently selected from the group consisting of C1-6 alkyl, deuterium, halogen, oxo, cyano, nitro, and —ORc, wherein the C1-6 alkyl is optionally substituted with one or more R7;
each Rc is independently selected from the group consisting of hydrogen, deuterium, C1-6 alkyl and C3-8 carbocyclyl wherein the C1-6 alkyl and C3-8 carbocyclyl are optionally substituted with one or more R6;
each R6 is independently selected from the group consisting of C1-6 alkyl, deuterium, C1-6 haloalkyl, C3-8 carbocyclyl, halogen, cyano, nitro, and —OH; and
and each R7 is independently selected from the group consisting of C1-6 alkyl, halogen and oxo.