Patent ID: 11866697
Assignee: THE BROAD INSTITUTE, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A  Y | IPC A  C

Claim 11:
12. The method of claim 11, wherein said Cpf1 nickase protein
is a Francisella novicida Cpf1 nickase and recognizes a PAM sequence of TTN, wherein N is A/C/G or T, or said Cpf1 nickase protein is a Prevotella albensis Cpf1p, Lachnospiraceae bacterium Cpf1 or Acidaminococcus sp. Cpf1 nickase and recognizes a PAM sequence of TTTV, wherein V is A/C or G; or
has been modified and recognizes an altered PAM sequence.