Patent ID: 11890289
Assignee: CORCEPT THERAPEUTICS INCORPORATED
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 7:
8. The method of claim 1, wherein the cyclohexyl pyrimidine has the following formula:, wherein
the dashed line is absent or a bond;
X is selected from the group consisting of O and S;
R1 is selected from the group consisting of cycloalkyl, heterocycloalkyl, aryl and heteroaryl, optionally substituted with from 1 to 3 R1a groups;
each R1a is independently selected from the group consisting of H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 alkoxy, C1-6 alkyl OR1b, halogen, C1-6 haloalkyl, C1-6 haloaloxy, OR1b, NR1bR1c, C(O)R1b, C(O)OR1b, OC(O)R1b, C(O)NR1bR1c, NR1bC(O)R1c, SO2R1b, SO2NR1bR1c, cycloalkyl, heterocycloalkyl, aryl and heteroaryl;
R1b and R1c are each independently selected from the group consisting of H and C1-6 alkyl;
R2 is selected from the group consisting of H, C1-6 alkyl, C1-6 alkyl-OR1b, C1-6 alkyl NR1bR1c and C1-6 alkylene heterocycloalkyl;
R3 is selected from the group consisting of H and C1-6 alkyl;
Ar is aryl, optionally substituted with 1-4 R4 groups;
each R4 is independently selected from the group consisting of H, C1-6 alkyl, C1-6 alkoxy, halogen, C1-6 haloalkyl and C1-6 haloalkoxy;
L1 is a bond or C1-6 alkylene; and
subscript n is an integer from 0 to 3,
or salts and isomers thereof.