Patent ID: 11964942
Assignee: ECCOGENE (SHANGHAI) CO., LTD.
Field: Organic fine chemistry (Chemistry)
Classification: CPC C  A | IPC C

Claim 0:
1. A compound of Formula (I), , or a pharmaceutically acceptable salt, solvate, stereoisomer, or tautomer thereof, wherein:
each X is independently Cl or F;
p is 0, 1, 2, or 3;
L is absent, —O—, (C1-C4) alkylene, substituted (C1-C4) alkylene, —O—(C1-C4) alkylene, substituted —O—(C1-C4) alkylene, (C1-C4) alkylene-O—, or substituted (C1-C4) alkylene-O—, wherein the substituted (C1-C4) alkylene, substituted —O—(C1-C4) alkylene, or substituted (C1-C4) alkylene-O— is substituted with one or more L1;
each L1 is independently (C1-C4) alkyl, F, or CF3; or two L1, together with the atom to which they are attached, form a 3- to 5-membered cycloalkyl ring;
each R1 is independently H, F, methyl, ethyl, or CF3;
R2 is (C1-C4) alkyl substituted with one or more (C1-C4) alkoxy, (C1-C4) alkoxy, NR3C(O)R4, or C(O)NR3R4; or
R2 is, , wherein R2 is optionally substituted with one or more R5;
R3 is H, methyl, or ethyl;
R4 is (C1-C4) alkyl or (C3-C10) cycloalkyl optionally substituted with one or more R8; or
R3 and R4, together with atom(s) to which they are attached, form a 3- to 6-membered ring optionally comprising one additional heteroatom selected from N and O and optionally substituted with one or more R5;
each R5 is independently (C1-C4) alkyl, (C1-C4) alkoxy, hydroxy, cyano, oxo, C(O)R7, C(O)NR7R7′, NR3C(O)R7, NR3S(O)2R4, S(O)2R4, (C1-C4) alkyl substituted with one or more hydroxy or R6, (C3-C10) cycloalkyl optionally substituted with one or more hydroxy or R6, or heterocyclyl comprising one or two 3- to 6-membering rings and 1 to 3 heteroatoms selected from N and O and optionally substituted with one or more hydroxy or R6; or two R5, together with the atom or atoms to which they are attached, form a 3- to 5-membered saturated or 5- or 6-membered aromatic ring optionally comprising 1 or 2 heteroatoms selected from N and O;
each R6 is independently NR3C(O)R7 or C(O)NR3R7;
each R7 is independently
OH, (C1-C4) alkoxy, (C1-C6) alkyl optionally substituted with one or more (C1-C4) alkoxy, CF3, F, or (C3-C10) cycloalkyl,
(C3-C10) cycloalkyl optionally substituted with one or more R8, or
phenyl optionally substituted with one or more R8;

each R7′ is independently H, methyl, or ethyl; or
R7 and R7′, together with the atom to which they are attached, form a 3- to 6-membered ring optionally comprising one additional heteroatom selected from N and O and optionally substituted with one or more R8; or
R3 and R7, together with atom(s) to which they are attached, form a 3- to 6-membered ring optionally comprising one additional heteroatom selected from N and O and optionally substituted with one or more R8; and
each R8 is independently (C1-C4) alkyl, (C1-C4) alkoxy, CF3, OH, or F.