Patent ID: 11932698
Assignee: NANJING LEGEND BIOTECH CO., LTD.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 21:
22. A polynucleotide comprising a nucleotide sequence encoding a chimeric antigen receptor (CAR), wherein the CAR comprises:
(a) an extracellular domain comprising a first polypeptide that binds specifically to a follicle-stimulating hormone receptor (FSHR) and an antigen binding fragment comprising:
a single domain antibody (sdAb) comprising a complementarity determining region 1 (CDR1), a CDR2 and a CDR3 having the polypeptide sequences of:
(i). SEQ ID NOs: 66, 134, and 202, respectively;
(ii). SEQ ID NOs: 34, 102, and 170, respectively; or
(iii). SEQ ID NOs: 67, 135, and 203, respectively;
(b) a transmembrane domain; and
(c) an intracellular signaling domain.