Patent ID: 11952601
Assignee: MERZ PHARMA GMBH & CO. KGAA
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C  Y | IPC A  C

Claim 15:
16. The recombinant botulinum neurotoxin of claim 1, wherein the botulinum neurotoxin comprises a first domain inserted at a position of the N-terminus of the functionally active botulinum neurotoxin light chain, and a second domain inserted at a position of the C-terminus of the functionally active botulinum neurotoxin heavy chain,
wherein both the first and second domain consist of 100-500 amino acid residues consisting of a plurality of amino acid repeats consisting of proline, alanine, serine, threonine, glycine and glutamate residues, wherein no more than six consecutive amino acid residues are identical, and wherein the first and second domain comprise the amino acid sequence of SEQ ID NO: 1.