Patent ID: 11905332
Assignee: REGENERON PHARMACEUTICALS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 22:
23. An isolated recombinant antibody or antigen-binding fragment thereof that specifically binds to human CD38, wherein the antibody or antigen-binding fragment thereof comprises sequences selected from the group consisting of:
(i) three heavy chain complementarity determining regions (CDRs) (HCDR1, HCDR2, and HCDR3) contained within a heavy chain variable region (HCVR) amino acid sequence of SEQ ID NOs: 2 or 32; and three light chain CDRs (LCDR1, LCDR2, and LCDR3) contained within a light chain variable region (LCVR) amino acid sequence of SEQ ID NO: 18 or 48;
(ii) three HCDRs contained within an HCVR amino acid sequence of SEQ ID NO: 2 and three LCDRs contained within an LCVR amino acid sequence of SEQ ID NO: 18;
(iii) three HCDRs contained within an HCVR amino acid sequence of SEQ ID NO: 32 and three LCDRs contained within an LCVR amino acid sequence of SEQ ID NO: 48;
(iv) an HCDR/LCDR amino acid sequence combination of SEQ ID NOs: 4-6-8-20-22-24;
(v) an HCDR/LCDR amino acid sequence combination of SEQ ID NOs: 34-36-38-50-52-54;
(vi) an HCVR amino acid sequence comprising SEQ ID NO: 2 or 32; and an LCVR amino acid sequence comprising SEQ ID NO: 18 or 48;
(vii) an HCVR amino acid sequence comprising SEQ ID NO: 2 and an LCVR amino acid sequence comprising SEQ ID NO: 18; and
(viii) an HCVR amino acid sequence comprising SEQ ID NO: 32 and an LCVR amino acid sequence comprising SEQ ID NO: 48.