Patent ID: 11884978
Assignee: IMMUNEXPRESS PTY LTD
Field: Measurement (Instruments)
Classification: CPC C  G | IPC C  G

Claim 0:
1. A method for treating a virus-associated inflammatory response syndrome (VaSIRS) in a human subject, wherein the human subject has at least one clinical sign of SIRS, the method comprising:
(1) in a blood sample taken from the subject, measuring an expression level for a polynucleotide expression product of ISG15 and an expression level for a polynucleotide expression product of IL16;
(2) determining a derived biomarker value for the blood sample, wherein the derived biomarker value being a ratio of the expression level of the polynucleotide expression product of ISG15 to the expression level of the polynucleotide expression product of IL16;
(3) determining whether the derived biomarker value for the blood sample is greater than a reference derived biomarker value determined from expression levels for the polynucleotide expression product of ISG15 and the expression levels for the polynucleotide expression product of IL16 in samples from non-VaSIRS control subjects; and
(4) if the derived biomarker value for the blood sample is greater than the reference derived biomarker value, administering to the subject an effective amount of a VaSIRS therapeutic agent.