Patent ID: 11971407
Assignee: ROCHE DIAGNOSTICS OPERATIONS, INC.
Field: Measurement (Instruments)
Classification: CPC G  C | IPC C  G

Claim 0:
1. An in vitro method for detecting an anti-tumor protein p53 (anti-p53) antibody in a sample having or suspected of having the anti-p53 antibody, the method comprising:
a) incubating the sample with a p53 capture antigen and a p53 detection antigen, the p53 detection antigen comprising the peptide of SEQ ID NO:1 at least twice, whereby a complex comprising the p53 capture antigen, the anti-p53 antibody, and the p53 detection antigen is formed,
b) separating the complex formed in (a) from unbound p53 detection antigen, and
c) measuring the complex separated in step (b) via the p53 detection antigen comprised therein, thereby detecting the anti-p53 antibody.