Patent ID: 11873291
Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
Field: Organic fine chemistry (Chemistry)
Classification: CPC C  A | IPC C

Claim 1:
2. A compound, wherein the compound is of Formula I-b-3:, or a pharmaceutically acceptable salt thereof, wherein:
Ring B1 is a 4- to 10-membered saturated or partially unsaturated monocyclic or bicyclic carbocyclic or heterocyclic ring having 1 to 3 heteroatoms independently selected from nitrogen, oxygen, phosphorus, and sulfur; or a benzotriazolyl, benzo[d]oxazol-2(3H)-one, benzo[d][1,3]dioxole, thienyl, pyrrolyl, imidazolyl, pyrazolyl, triazolyl, tetrazolyl, oxazolyl, isoxazolyl, oxadiazolyl, thiazolyl, isothiazolyl, thiadiazolyl, pyridyl, pyridazinyl, pyrimidinyl, pyrazinyl, or indolizinyl ring;
R1 is, , or an optionally substituted 5- to 6-membered heteroaryl ring having 1 to 4 heteroatoms independently selected from nitrogen, oxygen, and sulfur;
each R3 is independently halogen, —OMe, —OEt, —NR2, or —SR;
each R is independently hydrogen or an optionally substituted group selected from C1-6 aliphatic; benzyl; phenyl; a 4- to 7-membered saturated or partially unsaturated carbocyclic or heterocyclic ring having 1 to 3 heteroatoms independently selected from nitrogen, oxygen, and sulfur; and a 5- to 6-membered heteroaryl ring having 1 to 4 heteroatoms independently selected from nitrogen, oxygen, and sulfur,
R4 is hydrogen or an optionally substituted C1-6 aliphatic;
each R6 is independently halogen, —CN, ═CH2, ═O, —C(O)NHOH, —C(O)N(CH3)OH, —C(O)N(CH3)OCH3, —C(O)NHSO2CHF2, —OCONHCH2CO2Me, —OCONHCH2CO2H, —NHCOCH2CH2CO2H, —NHCOCH2CH2CO2CH3, —COR, —(CR2)0-4CO2R, —(CR2)0-4CONR2, —OR, —(CR2)1-4OR, —NR2, —(CR2)1-4NR2, —NRC(O)OR, —NRC(O)R, —NRC(O)NR2, —SR, —SO2R, —S(O)R, —(CR2)0-4SO3R, —(CR2)0-4SO2NR2, —(CR2)0-4OSO2NR2, —(CR2)0-4NRSO2R, —(CR2)0-4NRSO2OR, —(CR2)0-4OP(OR)2, —(CR2)0-4OP(O)(OR)2, —(CR2)0-4P(O)(OR)2, —(CR2)0-4OP(O)(H)OR, —B(OR)2,, , or RB;
RB is an optionally substituted group selected from C1-6 aliphatic; phenyl; a 4- to 10-membered saturated or partially unsaturated monocyclic or bicyclic carbocyclic or heterocyclic ring having 1 to 3 heteroatoms independently selected from nitrogen, oxygen, and sulfur; and a 5- to 6-membered heteroaryl ring having 1 to 4 heteroatoms independently selected from nitrogen, oxygen, and sulfur;
each Ra is independently H or C1-6alkyl;
each m is 0, 1, 2, 3, or 4; and
n is 1, 2, 3, or 4.