Patent ID: 11932640
Assignee: KING FAISAL UNIVERSITY
Field: Organic fine chemistry (Chemistry)
Classification: CPC C  A  Y | IPC A  C

Claim 3:
4. A method of treating a bacterial infection in a patient, comprising administering to a patient in need thereof a therapeutically effective amount of a compound, wherein the compound is selected from the group consisting of:
4-(7-fluoro-5-(methylamino)-1,3-dioxo-1,3-dihydro-2H-pyrrolo[3,4-b]quinolin-2-yl)benzoic acid (1),
3-((cyclohexyl(methyl)amino)methyl)-4-(7-fluoro-5-(methylamino)-1,3-dioxo-1,3-dihydro-2H-pyrrolo[3,4-b]quinolin-2-yl)benzoic acid (2),
4-(7-fluoro-5-(methylamino)-1,3-dioxo-1,3-dihydro-2H-pyrrolo[3,4-b]quinolin-2-yl)-3-((methyl(pentyl)amino)methyl)benzoic (3),
4-(9-((2-(dimethylamino)ethyl)amino)-7-fluoro-5-(methylamino)-1,3-dioxo-1,3-dihydro-2H-pyrrolo[3,4-b]quinolin-2-yl)benzoic acid (4),
4-(9-((3-aminopropyl)amino)-7-fluoro-5-(methylamino)-1,3-dioxo-1,3-dihydro-2H-pyrrolo[3,4-b]quinolin-2-yl)benzoic acid (5),
4-(7-fluoro-5-(methylamino)-9-(4-methylpiperazin-1-yl)-1,3-dioxo-1,3-dihydro-2H-pyrrolo[3,4-b]quinolin-2-yl)benzoic acid (6),
4-(7-fluoro-9-((3-methoxyphenyl)amino)-5-(methylamino)-1,3-dioxo-1,3-dihydro-2H-pyrrolo[3,4-b]quinolin-2-yl)benzoic acid (7),
4-(9-((3-aminopropyl)amino)-7-fluoro-5-(methylamino)-1,3-dioxo-1,3-dihydro-2H-pyrrolo[3,4-b]quinolin-2-yl)-3-((cyclohexyl(methyl)amino)methyl)benzoic acid (8),
4-(9-((3-aminopropyl)amino)-7-fluoro-5-(methylamino)-1,3-dioxo-1,3-dihydro-2H-pyrrolo[3,4-b]quinolin-2-yl)-3-((methyl(pentyl)amino)methyl)benzoic acid (9),
4-(7-fluoro-9-hydroxy-5-(methylamino)-1,3-dioxo-1,3-dihydro-2H-pyrrolo[3,4-b]quinolin-2-yl)benzoic acid (10),
3-((cyclohexyl(methyl)amino)methyl)-4-(7-fluoro-9-hydroxy-5-(methylamino)-1,3-dioxo-1,3-dihydro-2H-pyrrolo[3,4-b]quinolin-2-yl)benzoic acid (11),
4-(7-fluoro-9-hydroxy-5-(methylamino)-1,3-dioxo-1,3-dihydro-2H-pyrrolo[3,4-b]quinolin-2-yl)-3-((methyl(pentyl)amino)methyl)benzoic acid (12),, and a pharmaceutically acceptable salt, ester, stereoisomer, or solvate thereof;, wherein the bacterial infection is caused by Gram-positive Staphylococcus aureus, Staphylococcus aureus resistant to MRSA, Staphylococcus epidermidis, Bacillus subtilis, Enterococcus faecium, B Enterococcus faecium resistant to VRE, or Gram-negative Klebsiella pneumonia, Escherichia coli, or Pseudomonas aeruginosa.