Patent ID: 11951272
Assignee: CITY UNIVERSITY OF HONG KONG
Field: Medical technology (Instruments)
Classification: CPC A  Y | IPC A

Claim 20:
21. A cryo formulation-based microneedle device for ocular delivery of bioactive therapeutic agents, comprising:
one or more microneedle patches each including an array of miniaturized needles, each miniaturized needle defining a base end and a tip; and
a substrate to which the base end of each miniaturized needle of the array of miniaturized needles is attached or integrated thereto;
wherein the one or more microneedle patches are in a cryo status;
wherein each of the one or more microneedle patches is adapted to be applied on a cornea of an eye, in which the miniaturized needles penetrate into the eye;
wherein each of the one or more microneedle patches comprises a matrix solution, wherein the matrix solution comprises an aqueous base material and at least one cryoprotectant, the aqueous base solution includes glycerol, the cryoprotectant includes at least one of glycerol, sucrose, fructose, galactose, proteins, poly-l-lysine, starch, carboxymethyl cellulose (CMC), dextran, guar gum, pullulan, xanthan, xyloglucan, chondroitin, keratin and their derivatives thereof; and
wherein the miniaturized needles are further arranged to melt so as to release one or more bioactive therapeutic agents into the eye to achieve a targeted therapeutic effect.