Patent ID: 11919913
Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A compound having the structure:, R1, R2, R3, and R4, are each independently H, halogen, CF3 or C1-C4 alkyl, and R5 is halogen, CF3 or C1-C4 alkyl;
R6 is H, OH, or halogen;
B has the structure:, wherein
n is an integer from 0-2;
Z2 is S, O, or N—R7,
wherein R7 is H, C1-C10 alkyl, or oxetane;
Y1, Y2, Y3, and each occurrence of Y4 are each independently C(R9)2, N—R10, O, N, SO2, or C═O,
wherein
R9 is H or C1-C10 alkyl;
R10 is H, C1-C10 alkyl, C3-C6 cycloalkyl, (C1-C10 alkyl)-CF3, (C1-C10 alkyl)-OCH3, (C1-C10 alkyl)-halogen, SO2—(C1-C10alkyl), SO2—(C1-C10 alkyl)-CF3, SO2—(C1-C10 alkyl)-OCH3, SO2—(C1-C10 alkyl)-halogen, C(O)—(C1-C10 alkyl), C(O)—(C1-C10 alkyl)-CF3, C(O)—(C1-C10 alkyl)-OCH3, C(O)—(C1-C10 alkyl)-halogen, C(O)—NH—(C1-C10 alkyl), C(O)—N(C1-C4 alkyl)2, (C1-C10 alkyl)-C(O)OH, C(O)—NH2 or oxetane;

or a pharmaceutically acceptable salt thereof.