Patent ID: 11905301
Assignee: CLARITY PHARMACEUTICALS LTD
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A compound of formula (I),, wherein:
L is a nitrogen containing macrocyclic metal ligand of the formula, V is selected from the group consisting of N and CR4;
each Rx and Ry are independently selected from the group consisting of H, CH3, CO2H, NO2, CH2OH, H2PO4, HSO3, CN, CONH2 and CHO;
each p is independently an integer selected from the group consisting of 2, 3, and 4; R4 is selected from the group consisting of H, OH, halogen, NO2, NH2, optionally substituted C1-C12alkyl, optionally substituted C6-C18aryl, cyano, CO2R5, NHR5, N(R5)2 and a group of the formula:, wherein
X1 is a linking moiety;
Y1 is selected from the group consisting of OR6,SR7, N(R8)2 and a molecular recognition moiety;
wherein R5 is H or C1-C12alkyl;
R6 is selected from the group consisting of H, halogen, an oxygen protecting group, optionally substituted C1-C12alkyl, optionally substituted C2-C12alkenyl, optionally substituted C2-C12alkynyl and optionally substituted C2-C12 heteroalkyl;
R7 is selected from the group consisting of H, halogen, a sulfur protecting group, optionally substituted C1-C12alkyl, optionally substituted C2-C-12alkenyl, optionally substituted C2-C12alkynyl and optionally substituted C2-C12 heteroalkyl;
each R8 is independently selected from the group consisting of H, a nitrogen protecting group, optionally substituted C1-C12alkyl, optionally substituted C2-C12alkenyl, optionally substituted C2-C12alkynyl and optionally substituted C2-C12 heteroalkyl;
X is a linking moiety;
Y is a molecular recognition moiety, wherein the molecular recognition moiety is a cyclic RGD or a portion thereof; or
a pharmaceutically acceptable salt or complex thereof.