Patent ID: 11912792
Assignee: BICYCLETX LIMITED
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A  Y | IPC A  C

Claim 17:
18. A method for synthesizing compound BCY8245, or a salt thereof, the method comprising:, wherein:
 represents a solid-phase support;
compound BCY8234 is a bicyclic peptide ligand specific for Nectin-4 comprising a polypeptide and a molecular scaffold;
the polypeptide has an amino acid sequence: [β-Ala][Sar10]-(SEQ ID NO: 1), wherein SEQ ID NO: 1 is CiP[1Nal][dD]CiiM[HArg]DWSTP[HyP]WCiii; 1NaI represents 1-naphthylalanine; HArg represents homoarginine; HyP represents hydroxyproline; and Ci,Cii, and Ciii represent, respectively, first, second, and third cysteine residues; and
the molecular scaffold is 1,1’,1”-(1,3,5-triazinane-1,3,5-triyl)triprop-2-en-1-one (TATA), which forms covalent bonds with the cysteine residues of the polypeptide such that two polypeptide loops are formed on the molecular scaffold.