Patent ID: 11905332
Assignee: REGENERON PHARMACEUTICALS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 19:
20. An isolated bispecific antigen-binding molecule, comprising:
(a) a first antigen-binding domain that specifically binds human CD38 and that comprises an HCDR1 amino acid sequence of SEQ ID NO: 34, an HCDR2 amino acid sequence of SEQ ID NO: 36, and an HCDR3 amino acid sequence of SEQ ID NO: 38; and
(b) a second antigen binding domain that specifically binds human CD28 and that comprises an HCDR1 amino acid sequence of SEQ ID NO: 42, an HCDR2 amino acid sequence of SEQ ID NO: 44, and an HCDR3 amino acid sequence of SEQ ID NO: 46; and
(c) an LCVR comprising an LCDR1 amino acid sequence of SEQ ID NO: 50, an LCDR2 amino acid sequence of SEQ ID NO: 52, and an LCDR3 amino acid sequence of SEQ ID NO: 54.