Patent ID: 11896674
Assignee: SUZHOU RIBO LIFE SCIENCE CO., LTD.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 15:
16. The siRNA conjugate according to claim 1, wherein the siRNA is any one of the following siRNAs:
siHB1M1
Sense strand: GmAmAmAmGmUmAfUfGfUmCmAmAmCmGmAmAmUmUm (SEQ ID NO: 11)
Antisense strand: AmAfUmUmCmGfUmUmGmAmCmAmUmAfCmUfUmUmCmUmUm (SEQ ID NO: 13)
siHB2M1
Sense strand: GmAmAmAmGmUmAfUfGfUmCmAmAmCmGmAmAmUmUm (SEQ ID NO:11)
Antisense strand: AmAfUmUmCmGfUmUmGmAmCmAmUmAfCmUfUmUmCmCmAm (SEQ ID NO: 14)
siHB3M1
Sense strand: GmAmAmAmGmUmAfUfGfUmCmAmAmCmGmAmAmUmAm (SEQ ID NO: 12)
Antisense strand: UmAfUmUmCmGfUmUmGmAmCmAmUmAfCmUfUmUmCmUmUm (SEQ ID NO: 15)
siHB4M1
Sense strand: GmAmAmAmGmUmAfUfGfUmCmAmAmCmGmAmAmUmAm (SEQ ID NO: 12)
Antisense strand: UmAfUmUmCmGfUmUmGmAmCmAmUmAfCmUfUmUmCmCmAm (SEQ ID NO: 16)
siHB1M2
Sense strand: GmAmAmAmGfUmAfUfGfUmCmAmAmCmGmAmAmUmUm (SEQ ID NO: 17)
Antisense strand: AmAfUmUmCmGfUmUfGfAmCmAmUmAfCmUfUmUmCmUmUm (SEQ ID NO: 19)
siHB2M2
Sense strand: GmAmAmAmGfUmAfUfGfUmCmAmAmCmGmAmAmUmUm (SEQ ID NO: 17)
Antisense strand: AmAfUmUmCmGfUmUfGfAmCmAmUmAfCmUfUmUmCmCmAm (SEQ ID NO: 20)
siHB3M2
Sense strand: GmAmAmAmGfUmAfUfGfUmCmAmAmCmGmAmAmUmAm (SEQ ID NO: 18)
Antisense strand: UmAfUmUmCmGfUmUfGfAmCmAmUmAfCmUfUmUmCmUmUm (SEQ ID NO: 21)
siHB4M2
Sense strand: GmAmAmAmGfUmAfUfGfUmCmAmAmCmGmAmAmUmAm (SEQ ID NO: 18)
Antisense strand: UmAfUmUmCmGfUmUfGfAmCmAmUmAfCmUfUmUmCmCmAm (SEQ ID NO: 22)
siHB1M3
Sense strand: GmAmAmAmGfUmAfUfGfUmCmAmAmCmGmAmAmUmUm (SEQ ID NO: 17)
Antisense strand: AmAfUmUmCmGfUmUmGmAmCmAmUmAfCmUfUmUmCmUmUm (SEQ ID NO: 13)
siHB2M3
Sense strand: GmAmAmAmGfUmAfUfGfUmCmAmAmCmGmAmAmUmUm (SEQ ID NO: 17)
Antisense strand: AmAfUmUmCmGfUmUmGmAmCmAmUmAfCmUfUmUmCmCmAm (SEQ ID NO: 14)
siHB3M3
Sense strand: GmAmAmAmGfUmAfUfGfUmCmAmAmCmGmAmAmUmAm (SEQ ID NO: 18)
Antisense strand: UmAfUmUmCmGfUmUmGmAmCmAmUmAfCmUfUmUmCmUmUm (SEQ ID NO: 15)
siHB4M3
Sense strand: GmAmAmAmGfUmAfUfGfUmCmAmAmCmGmAmAmUmAm (SEQ ID NO: 18)
Anti sense strand: UmAfUmUmCmGfUmUmGmAmCmAmUmAfCmUfUmUmCmCmAm (SEQ ID NO: 16)
siHB5M1
Sense strand: UmGmGmAmAmAmGmUmAfUfGfUmCmAmAmCmGmAmAmUmAm (SEQ ID NO: 51)
Anti sense strand: UmAfUmUmCmGfUmUmGmAmCmAmUmAfCmUfUmUmCmCmAmUmUm (SEQ ID NO: 52)
siHB6M2
Sense strand: UmGmGmAmAmAmGfUmAfUfGfUmCmAmAmCmGmAmAmUmAm (SEQ ID NO: 51)
Anti sense strand: UmAfUmUmCmGfUmUfGfAmCmAmUmAfCmUfUmUmCmCmAmAmUm (SEQ ID NO: 53)
siHB7M3
Sense strand: UmGmGmAmAmAmGfUmAfUfGfUmCmAmAmCmGmAmAmUmUm (SEQ ID NO: 54)
Anti sense strand: AmAfUmUmCmGfUmUmGmAmCmAmUmAfCmUfUmUmCmCmAmUmUm (SEQ ID NO: 55).