Patent ID: 11946050
Assignee: APTAH BIO, INC.
Field: Biotechnology (Chemistry)
Classification: CPC C | IPC C

Claim 20:
21. A set of engineered polynucleotides each independently comprising: (i) one or more nucleotide sequences complementary to a splice site and a sequence 5′ or 3′ to the splice site of a pre-messenger ribonucleic acid (pre-mRNA) and (ii) a recruiting nucleotide sequence comprising a sequence complementary to at least 4 nucleotides of a sequence of Stem-Loop II (SL2) of an U1 snRNA and/or a sequence comprising a phosphorothioate internucleotide linkage that binds to a U1-C protein zinc finger, wherein said set of engineered polynucleotides specifically bind said pre-mRNA at a plurality of target sequences.