Patent ID: 11963997
Assignee: JILIN UNIVERSITY
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 5:
6. A method of treating a patient in need thereof comprising the steps of:
1) selecting a patient having a disease caused by abnormal expression of an anti-apoptotic protein in Bcl-2 family proteins selected from malignant tumors, hematological tumor-based diseases, neurodegenerative diseases, and autoimmune diseases; and 2) administering a therapeutically effective amount of a drug to the patient, the drug comprising a fluorescent polymeric nanomicelle, the fluorescent nanomicelle comprising an anti-tumor polypeptide Bax-BH3 and a polymer carrier prepared in accordance with the method of claim 2,
wherein the anti-tumor polypeptide Bax-BH3 has an amino acid sequence set forth in SEQ ID No. 1, and
wherein the polymer carrier is a block copolymer, the block copolymer is RGD-PHPMA-b-Poly(MMA-alt-(Rhob-MA)).