Patent ID: 11883467
Assignee: ELGAN PHARMA LTD
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 6:
7. A method of preparing an amorphous insulin powder soluble in water comprising:
(a) solubilizing insulin in hydrochloric acid to obtain solubilized insulin;
(b) diluting said solubilized insulin with water and adjusting a pH to 6.9-8.0.
(c) dissolving dextrin in water and adjusting pH to 7.0-7.5
(d) adding insulin solution (b) to dextrin solution (c) to thereby sequester said insulin in cavities of said dextrin molecules;
(e) adjusting pH of solution (d) to 6.9-8.0; and
(f) freeze drying the solution of (e) to obtain the amorphous insulin powder.