Patent ID: 11879126
Assignee: NUTCRACKER THERAPEUTICS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC B  C  A  Y | IPC A  C

Claim 9:
10. A therapeutic mRNA composition comprising:
a single mRNA scaffold, wherein the single mRNA scaffold comprises:
a 5′ UTR,
a first immunomodulatory mRNA open reading frame encoding interleukin-12, wherein the first immunomodulatory mRNA open reading frame has at least about 80% nucleic acid sequence identity to SEQ ID NO:5,
a tumor-specific antigen mRNA open reading frame encoding HPV16 E6 E7,
a second immunomodulatory mRNA open reading frame encoding TNFSF14, wherein the second immunomodulatory mRNA open reading frame has at least about 80% nucleic acid sequence identity to SEQ ID NO:11,
and a 3′UTR,, wherein the single mRNA scaffold is encapsulated in a delivery vehicle, wherein the delivery vehicle is selected from the group consisting of wherein the delivery vehicle is selected from the group consisting of lipid nanoparticles, polymer-based nanoparticles, cationic lipids, ionizable lipids, amino-lipidated peptoids, amphipathic molecules/nanoparticles, and tertiary amino lipidated cationic peptoids.