Patent ID: 11963965
Assignee: NATIONAL JEWISH HEALTH
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 3:
4. The method of claim 2, wherein the at least one residual function mutation is an amino acid substitution of wild-type CFTR amino acid sequence SEQ ID NO:1 selected from the group consisting of E56K, P67L, R74W, D110E, D110H, R117C, R117H, G178R, E193K, L206W, R347H, R352Q, A455E, S549N, S549R, G551D, G551S, D579G, S945L, S977F, F1052V, K1060T, A1067T, R1070W, F1074L, D1152H, G1244E, S1251N, S1255P, D1270N, and G1349D.