Patent ID: 11918709
Assignee: JMEDTECH COATING TECHNOLOGIES PTE LTD
Field: Medical technology (Instruments)
Classification: CPC A | IPC A

Claim 0:
1. A medical device, comprising a covalently-bonded heparin coating on a substrate, where the covalently bonded heparin coating is the reaction product of:
(a) an isocyanate-bearing material on or covalently bonded to the substrate, which isocyanate-bearing material comprises one or more isocyanate groups; and
(b) a heparin molecule selected from one or more of the following formulae:
Ia: (A1)[[z]]-Heparin, where there are one or more A1 groups attached to the Heparin backbone;, , where there are one or more of each of the A1 and A2 groups attached to the Heparin backbone; and
Ic: {([HS(CH2)n]m-L2-[(CH2)nS(CH2)oO])[[z]]-Heparin}p, where there are one or more ([HS(CH2)n]m-L2-[(CH2)nS(CH2)oO])— groups attached to the Heparin backbone and the oxygen atom bonded to Heparin is part of the Heparin molecule;
Id: {([HS(CH2)n′]m′-L3-[(CH2)n′S(CH2)o′COO])[[z]]-Heparin}p′, where there are one or more ([HS(CH2)n′]m′-L3-[(CH2)n′S(CH2)o′COO])— groups attached to the Heparin backbone and the terminal oxygen atom of the COO group bonded to Heparin is part of the Heparin molecule;
Ie: {([HS(CH2)n″]m″-L4-[(CH2)n″S(CqH2q-2)O])[[z]]-Heparin}p″, where there are one or more ([HS(CH2)n″]m″-L4-[(CH2)n″S(CqH2q-2)O])— groups attached to the Heparin backbone and the oxygen atom bonded to Heparin is part of the Heparin molecule; and
If: a network of heparin molecules comprising fixing portions of formula Ifi:, where there are one or more {[HS(CH2)n′″]m′″-L5-[(CH2)n′″S]2(CqH2q-1)O}— groups attached to the Heparin backbone and the oxygen atom bonded to Heparin is part of the Heparin molecule; and
network extending portions of formula Ifii:, , where there are one or more [S(CgH2q-1)O]— groups attached to the Heparin backbone and the oxygen atom bonded to Heparin is part of the Heparin molecule;
where:
each A1 and A2 independently represent:
HO—;
H(OCHR1CH2)xO—, where the terminal oxygen atom is part of the Heparin molecule; or
H(OCHR1CHR2)xO—, where R1 and R2, together with the atoms they are attached to, form a carbocylic ring system having from 3 to 10 carbon atoms;
L1 represents a crosslinking moiety;
each n, n′, n″, n′″, o and o′ independently represent 1 to 20;
each m, m′, m″, m′″, p, p′, p″, p′″ and p″″ independently represent 1 to 20;
each q independently represents 1 to 20;
each L2 to L5 each independently represent a linking group;
R1 represents H or a C1 to C20 alkyl group;
x represents from 1 to 20;
| in formula Ib represents a covalent bond between a Heparin molecule and the crosslinking moiety;
each | in formula Ifi represents a point of attachment to a further fixing portion of formula Ifi or to an extending portion of formula Ifii;
each | in formula Ifii represents a point of attachment to a fixing portion of formula Ifi or to a further extending portion of formula Ifii;
each Heparin molecule is a polyanionic molecule, where each negative charge is balanced by a cation, wherein:
the cations are substantially quaternary ammonium ions; and
the isocyanate-bearing material is a coating on the substrate or is covalently bonded to the substrate.