Patent ID: 11932673
Assignee: MAXION THERAPEUTICS LIMITED
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC C

Claim 0:
1. A binding member that binds and inhibits human sodium channel Nav1.7, the binding member comprising a fusion protein and a partner domain, wherein
the fusion protein comprises a donor diversity scaffold domain inserted into a recipient diversity scaffold domain, wherein the donor diversity scaffold domain comprises a donor scaffold and a donor interaction sequence, and wherein the recipient diversity scaffold domain comprises a recipient scaffold and a recipient interaction sequence, wherein
the donor diversity scaffold domain is a peptide which binds to the voltage sensing domain of Nav1.7 and has at least 95% sequence identity to (i) ProTx-III (SEQ ID NO: 366), (ii) ProTx-II (SEQ ID NO: 10), (iii) Huwentoxin-IV ((SEQ ID NO: 8), (iv) Ssm6a ((SEQ ID NO: 12), or (v) GpTx-1 4M (SEQ ID NO: 364),
wherein the recipient diversity scaffold domain is an antibody variable domain, and
wherein the partner domain is an antibody variable domain.