Patent ID: 11891418
Assignee: BISY E.U.
Field: Biotechnology (Chemistry)
Classification: CPC C | IPC C

Claim 12:
13. A methylotrophic Komagataella yeast comprising an orthologous promoter obtained from a Hansenula yeast cell or a variant of the orthologous promoter, inducible by derepression,
wherein the orthologous promoter is an orthologous formate dehydrogenase (FMD) promoter comprising the nucleic acid sequence of SEQ ID NO: 1,
wherein the variant of the orthologous promoter comprises a nucleic acid sequence selected from the group consisting of SEQ ID NO: 35, SEQ ID NO: 39, SEQ ID NO: 44, SEQ ID NO: 51, SEQ ID NO: 52, SEQ ID NO: 54, SEQ ID NO: 55 and SEQ ID NO: 56, and
wherein the orthologous promoter or the variant of the orthologous promoter is operably linked to a nucleic acid molecule encoding a heterologous or homologous polypeptide.