Patent ID: 11883387
Assignee: HELMHOLTZ-ZENTRUM FüR INFEKTIONSFORSCHUNG GMBH
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 0:
1. A compound having the formula (I):, or a pharmacologically acceptable salt thereof,
wherein
A represents a group:, wherein
said group A is as defined in (i) or (ii):
(i) A1 is CH; A2 is N;
A3 is N or C—RA3,
RA3 represents a hydrogen atom, a halogen atom, CF3, CN, C(═O)NH2, C(═O)OH, CH2OH, CH2NH2, OH, OMe, or NH2; and

RA represents CF3, CN, Cl, NO2 or F; or

(ii) A1 is N; A2 is N; A3 is C—NH2; and RA represents CF3, CN, Cl, NO2 or F;
L is a group represented by formula (L-1) or (L-2):, wherein
X1 is NH or S;
ring B is a partially unsaturated or aromatic, 5-membered heterocyclic ring represented by formula (B-1) or 6-membered heterocyclic ring represented by formula (B-2):, wherein
the ring represented by formula (B-1) is:
(i) a ring, wherein M1 is CH; M2 is C or N; and each of M3 and M4, independently of one another, is N or NH; or
(ii) a ring, wherein M1 is S; M2 is C; M3 is N; and M4 is CH;

M11, M12, M13, and M14 each, independently of one another, represents CH or N;, at least one of M11, M12, M13, and M14 being a group with a heteroatom as defined above;
U1 and U2 each, independently of one another, represents N or C(R′);
R1, at each occasion independently, represents a hydrogen atom, a halogen atom, OH, CN, CF3, CH2—OH, OCH3, OCF3; or an alkyl, alkenyl, alkynyl, heteroalkyl, cycloalkyl, heterocyclo-alkyl, alkylcycloalkyl, heteroalkylcycloalkyl, aryl, heteroaryl, aralkyl or heteroaralkyl group;

each “”, independently of one another, represents a single bond or a double bond, wherein at least one “” in each of the rings of formulae (L-1), (B-1) and (B-2) is a double bond;, wherein
X2 is NH, O or S;
Y1 represents N, NH, S or O;
Y2 represents N or C(R11);
Y3 represents N or NH;
R11 represents a hydrogen atom, a halogen atom, OH, CN, CF3, CH2—OH, OCH3, OCF3; or an alkyl, alkenyl, alkynyl, heteroalkyl, cycloalkyl, heterocycloalkyl, alkylcycloalkyl, heteroalkylcycloalkyl, aryl, heteroaryl, aralkyl or heteroaralkyl group;
each “” independently of one another, represents a single bond or a double bond, wherein at least one “” in the ring of formula (L-2) is a double bond;
T is R2 or a group: —Y—R3, wherein
R2 is a hydrogen atom, a halogen atom, CN, CF3, CH2—OH; NRT1RT2; or an alkyl, alkenyl, alkynyl, heteroalkyl, cycloalkyl, heterocycloalkyl, alkylcycloalkyl, heteroalkylcycloalkyl, aryl, heteroaryl, aralkyl or heteroaralkyl group, all of which groups may optionally be substituted;
RT1 and RT2 each, independently of one another, represents a hydrogen atom or a (C1-C3)alkyl group, which may be substituted by one or more, identical or different, group(s) selected from a halogen atom, OH, ═O, and NH2;

Y is —O— or —S—; and
R3 is a hydrogen atom; or an alkyl, alkenyl, alkynyl, heteroalkyl, cycloalkyl, heterocyclo-alkyl, alkylcycloalkyl, heteroalkylcycloalkyl, aryl, heteroaryl, aralkyl or heteroaralkyl group, all of which groups may optionally be substituted.