Patent ID: 11912709
Assignee: UNIVERSITY OF MASSACHUSETTS
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 10:
11. The temozolomide compound of claim 1, wherein
the phosphorylcholine zwitterionic group is of the formula A-B—C—, wherein A is an ammonium group of the formula —N(R7)3, wherein R7 is a C1-6 alkyl group; B is a divalent C1-6 alkylene group; and C is a divalent phosphate group;
the sulfobetaine zwitterionic group is of the formula A-B—C-L2-, wherein A is a sulfonate group; B is a divalent C1-6 alkylene group; C is a divalent ammonium group; and L2 is a divalent C1-6 alkylene group; wherein L2 of the zwitterionic group is covalently bound to L1 through a thioether bond or a disulfide bond; and
the carboxybetaine zwitterionic group is of the formula A-B—C-L2-, wherein A is a carboxylate group; B is a divalent C1-6 alkylene group; C is a divalent ammonium group; and L2 is a divalent C1-6 alkylene group; wherein L2 of the zwitterionic group is covalently bound to L1 through a thioether bond or a disulfide bond.