Patent ID: 11891387
Assignee: JANSSEN PHARMACEUTICA NV
Field: Organic fine chemistry (Chemistry)
Classification: CPC C  A | IPC C

Claim 0:
1. A compound of Formula (I):, wherein
R1a is C1-4alkyl;
R1b is H;
or R1a and R1b taken together form —CH2CH2— or —CH2CH2CH2—;
R2 is selected from:
(a) phenyl or pyridyl, each optionally substituted with one or two substituents selected from halo, C1-4alkyl, C1-4haloalkyl, OC1-4alkyl, OC1-4haloalkyl, N-linked monocyclic or bicyclic heterocycloalkyl, monocyclic heteroaryl, and C3-6cycloalkyl, or two adjacent ring substituents taken together with the carbons to which they are attached form a monocyclic cycloalkyl or hetercycloalkyl ring; and
(b) bicyclic heteroaryl optionally substituted with one or two substituents selected from halo, C1-4alkyl, C1-4haloalkyl, OC1-4alkyl, OC1-4haloalkyl, N-linked monocyclic or bicyclic heterocycloalkyl, monocyclic heteroaryl, and C3-6cycloalkyl; and

R3 is 1H—C1-4alkyl-pyrazolyl, 1H—C1-4haloalkyl-pyrazolyl, 1H-pyridyl-pyrazolyl, 1H—(C3-6cycloalkyl)-pyrazolyl, or 1H—(C3-6cycloalkyl-methyl)-pyrazolyl, each pyrazolyl optionally substituted with halo, C1-4alkyl, C1-4haloalkyl, OC1-4alkyl, or OC1-4haloalkyl;
provided that when R2 is phenyl or pyridyl, each optionally substituted with halo, C1-4alkyl, or C1-4haloalkyl, then (a) R1a and R1b are taken together form —CH2CH2— or —CH2CH2CH2—;
or (b) R3 is not 1H—C1-4alkyl-pyrazol-5-yl, or 1H—C1-4haloalkyl-pyrazol-5-yl, or a pharmaceutically acceptable salt, isotope, N-oxide, solvate, or stereoisomer thereof.