Patent ID: 11891661
Assignee: ROCHE SEQUENCING SOLUTIONS, INC.
Field: Measurement (Instruments)
Classification: CPC C  G | IPC C  G

Claim 0:
1. A method of detecting whether a membrane has thinned in a cell of a nanopore based sequencing chip, comprising:
applying a first voltage across a membrane disposed between a working electrode and a counter electrode, the membrane electrically coupled with a capacitor;
periodically sampling a second voltage across the capacitor;
determining a change in the sampled second voltage across the capacitor in response to a change in the first voltage; and
detecting that the membrane has been thinned at least partially into a thin membrane based on the determined change in the sampled second voltage across the capacitor in response to the change in the first voltage, wherein the thin membrane has a thickness that allows a nanopore to insert into the thin membrane and form an electrical path between the working electrode and the counter electrode.