Patent ID: 11912744
Assignee: ANTIBIOTIC ALTERNATIVES LLC
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A  Y | IPC A  C

Claim 0:
1. A method for increasing resistance to a pathogen in a subject comprising:
topically applying to a mucosal squamous epithelial cell of the subject a composition comprising (i) at least one in vitro transcribed isolated mRNA that comprises a synthetic 5′ cap and that encodes at least two polypeptides involved in innate immunity, wherein the polypeptides comprise cathelicidin antimicrobial protein (CAMP) and calprotectin, and (ii) a pharmaceutically acceptable in vivo delivery vehicle formulated for topical application to the mucosal squamous epithelial cell, whereby the topical application provides transfection in vim of the isolated mRNA to express the polypeptides in an amount effective to increase resistance to a pathogen in the mucosal squamous epithelial cell.