Patent ID: 11957658
Assignee: NIVAGEN PHARMACEUTICALS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 15:
16. A method for making a stabilized chlorthalidone suspension, comprising:
forming a first mixture by
adding a solubilizing or wetting agent to a first volume of water having a temperature of between about 25° C. to 30° C. with stirring;
wherein the first volume of water is 50% of the stabilized chlorthalidone suspension;
adding a suspending agent to the first volume of water with stirring and homogenizing; and
adding at least one viscosity increasing agent or at least one anti-caking agent to the first volume of water with stirring and homogenizing;

forming a second mixture by
adding a sweetening agent to a second volume of water with stirring;
adding a viscosity increasing agent to the second volume of water with stirring; and
adding chlorthalidone at between about 5 to 20 mg/mL to the second volume of water with stirring and homogenizing; and

forming the stabilized chlorthalidone suspension by
adding the first mixture to the second mixture with stirring to form a third mixture;
optionally adding a third volume of water to the third mixture to thereby render a final volume; and
homogenizing the third mixture to form the stabilized chlorthalidone suspension.