Patent ID: 11891385
Assignee: KING FAISAL UNIVERSITY
Field: Organic fine chemistry (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 5:
6. A method of making the 1-cyclopropyl-7-(4-((5-(3,5-dichlorobenzylideneamino)-2-thioxo-1,3,4-thiadiazol-3(2H)-yl)methyl)piperazin-1-yl)-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid compound of claim 1, the method comprising:
adding a solution of 5-(3,5-dichlorobenzylideneamino)-1,3,4-thiadiazole-2(3H)-thione in formaldehyde to ethanol to obtain a reaction mixture;
stirring the reaction mixture;
adding ciprofloxacin HCl and triethylamine to the reaction mixture;
stirring the reaction mixture with reflux;
purifying the crude product by recrystallization using ethanol; and
obtaining the 1-cyclopropyl-7-(4-((5-(3,5-dichlorobenzylideneamino)-2-thioxo-1,3,4-thiadiazol-3(2H)-yl)methyl)piperazin-1-yl)-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid.