Patent ID: 11858986
Assignee: THE BRIGHAM AND WOMEN'S HOSPITAL
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 10:
11. A first isolated nucleic acid molecule comprising a nucleotide sequence encoding an immunoglobulin heavy chain, or antigen-binding fragment thereof, wherein the heavy chain or antigen-binding fragment comprises the CDR-H1, CDR-H2, and CDR-H3 sequences of SEQ ID NO: 28, and
a second isolated nucleic acid molecule comprising a nucleotide sequence encoding an immunoglobulin light chain, or antigen-binding fragment thereof, wherein the light chain or antigen-binding fragment comprises:
i) the CDR-L1, CDR-L2, and CDR-L3 sequences of SEQ ID NO: 2;
ii) the CDR-L1, CDR-L2, and CDR-L3 sequences of SEQ ID NO: 3;
iii) the CDR-L1, CDR-L2, and CDR-L3 sequences of SEQ ID NO: 4;
iv) the CDR-L1, CDR-L2, and CDR-L3 sequences of SEQ ID NO: 5;
v) the CDR-L1, CDR-L2, and CDR-L3 sequences of SEQ ID NO: 6;
vi) the CDR-L1, CDR-L2, and CDR-L3 sequences of SEQ ID NO: 7;
vii) the CDR-L1, CDR-L2, and CDR-L3 sequences of SEQ ID NO: 8;
viii) the CDR-L1, CDR-L2, and CDR-L3 sequences of SEQ ID NO: 9;
ix) the CDR-L1, CDR-L2, and CDR-L3 sequences of SEQ ID NO: 10;
x) the CDR-L1, CDR-L2, and CDR-L3 sequences of SEQ ID NO: 11;
xi) the CDR-L1, CDR-L2, and CDR-L3 sequences of SEQ ID NO: 12;
xii) the CDR-L1, CDR-L2, and CDR-L3 sequences of SEQ ID NO: 13;
xiii) the CDR-L1, CDR-L2, and CDR-L3 sequences of SEQ ID NO: 14;
xiv) the CDR-L1, CDR-L2, and CDR-L3 sequences of SEQ ID NO: 15;
xv) the CDR-L1, CDR-L2, and CDR-L3 sequences of SEQ ID NO: 16;
xvi) the CDR-L1, CDR-L2, and CDR-L3 sequences of SEQ ID NO: 17;
xvii) the CDR-L1, CDR-L2, and CDR-L3 sequences of SEQ ID NO: 18;
xviii) the CDR-L1, CDR-L2, and CDR-L3 sequences of SEQ ID NO: 19;
xix) the CDR-L1, CDR-L2, and CDR-L3 sequences of SEQ ID NO: 20;
xx) the CDR-L1, CDR-L2, and CDR-L3 sequences of SEQ ID NO: 21;
xxi) the CDR-L1, CDR-L2, and CDR-L3 sequences of SEQ ID NO: 22;
xxii) the CDR-L1, CDR-L2, and CDR-L3 sequences of SEQ ID NO: 23;
xxiii) the CDR-L1, CDR-L2, and CDR-L3 sequences of SEQ ID NO: 24;
xxiv) the CDR-L1, CDR-L2, and CDR-L3 sequences of SEQ ID NO: 25;
xxv) the CDR-L1, CDR-L2, and CDR-L3 sequences of SEQ ID NO: 26;
xxvi) the CDR-L1, CDR-L2, and CDR-L3 sequences of SEQ ID NO: 27; or
xxvii) the CDR-L1, CDR-L2, and CDR-L3 sequences of SEQ ID NO: 1.