Patent ID: 11914034
Assignee: WASHINGTON UNIVERSITY
Field: Medical technology (Instruments)
Classification: CPC A  G | IPC A  G

Claim 16:
17. At least one non-transitory computer-readable storage medium having computer-executable instructions embodied thereon for generating a functional image of a lesion region of a subject using diffuse optical tomography (DOT), wherein when executed by at least one processor, the computer-executable instructions cause the processor to:
emit optical waves toward a lesion region of the subject;
detect optical waves reflected by the lesion region and converting the optical waves to digital signals;
generate a 3D target shape from a plurality of co-registered ultrasound images using a semi-automated interactive convolutional neural network (CNN);
generate a regularization matrix from the 3D target shape; and
perform reconstruction for the digital signals using a depth-regularized reconstruction algorithm combined for depth-dependent reconstruction of absorption distribution in which reconstruction is constrained by the regularization matrix.