Patent ID: 11878989
Assignee: SHANGHAI FOREFRONT PHARMA CO., LTD.
Field: Organic fine chemistry (Chemistry)
Classification: CPC C  Y | IPC C

Claim 8:
9. The method for preparing the L-erythro biopterin compound according to claim 1, wherein when the alkene in the compound represented by formula (II) is of a trans structure and its structural formula is represented by formula (IIb), the steps for preparing the L-erythro biopterin compound represented by formula (I) from the compound represented by formula (IIb) are as follows:
the compound represented by the formula (IIb) is subjected to a dihydroxylation reaction to prepare the compound represented by the formula (IVb-1) and/or formula (IVb-2);
the compound represented by formula (IVb-1) and/or formula (IVb-2) undergoes an acetylation reaction to obtain the compound represented by formula (VIIb-1) and/or formula (VIIb-2);
the compound represented by formula (VIIb-1) and/or formula (VIIb-2) undergoes the Mitsunobu reaction to obtain the compound represented by formula (VIIb-3) and/or formula (VIIb-4);
the compound represented by (VIIb-3) and/or formula (VIIb-4) undergoes a cyclization reaction with, and/or the salt of, to obtain the L-erythro biopterin compound represented by formula (I);, wherein R10 is substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocyclic alkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
E is halogen, C1-4 alkoxy, C1-4 alkylthio or —NH2.