Patent ID: 11865148
Assignee: KRYSTAL BIOTECH, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 10:
11. A method of delivering a human transgene to an eye of a subject, the method comprising:
providing a pharmaceutical composition comprising:
a) a replication-defective HSV-1 comprising a recombinant HSV-1 genome, wherein the recombinant HSV-1 genome comprises one or more polynucleotides comprising the human transgene, wherein the one or more polynucleotides comprising the human transgene are operably linked to a promoter suitable for transcription in a mammalian cell,
wherein the recombinant HSV-1 genome comprises an inactivating mutation in one or both copies of the ICP4 HSV-1 gene,
wherein the replication-defective HSV-1 is suitable for delivering the one or more polynucleotides comprising the human transgene to the epidermis and/or dermis of the subject; and
b) a pharmaceutically acceptable carrier; and

administering the pharmaceutical composition topically or via injection to the eye of the subject that has a disorder or disease of the eye associated with vision loss.