Patent ID: 11925696
Assignee: PURDUE RESEARCH FOUNDATION
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 0:
1. A conjugate of the formula B-L-A, wherein B is a binding ligand of carbonic anhydrase IX (CA IX) having the formula, , wherein
wherein each R6 and R7 is independently selected from the group consisting of H, OR9, —OC(O)R9, —OC(O)NR9R10, —OS(O)R9, —OS(O)2R9, —SR9, —S(O)R9, —S(O)2R9, —S(O)NR9R10, S(O)2NR9R10, —OS(O)NR9R10, —OS(O)2NR9R10, —NR9R10, —NR9C(O)R10, —NR9C(O)OR10, —NR9C(O)NR9R10, —NR9S(O)R10, —NR9S(O)2R10, —NR9S(O)NR9R10, —NR9S(O)2NR9R10, —C(O)R9, —C(O)OR9, and —C(O)NR9R10;
R8 is selected from the group consisting of H, C1-C6 alkyl, C2-C6 alkenyl, and C2-C6 alkynyl, —C(O)R11, —C(O)OR11, and —C(O)NR11R12;
Y is —NR9′—;
Z is —NR10′—;
each R9, R10, R9′, R10′ R11 and R12 is independently selected from the group consisting of H, C1-C6 alkyl, C2-C6 alkenyl, and C2-C6 alkynyl;
p is an integer from 1 to 4;
r is an integer from 0 to 4;
t is an integer from 1 to 3; and
* represents a covalent bond to L;
wherein L is a linker of 2 to 100 atoms in length covalently attached to B and A, and
wherein A is a therapeutic agent, or an imaging agent selected from a rhodamine dye and a single-photon emission computed tomography (SPECT) imaging agent, and A is covalently attached to L.