Patent ID: 11957659
Assignee: PSILO SCIENTIFIC, LTD.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 20:
21. A process for obtaining a transmucosal psychoactive alkaloid composition, the process comprising:
mixing a dried powdered psychoactive alkaloid source with an acidified solvent to obtain a slurry, wherein:
the dried powdered psychoactive alkaloid source comprises psilocin, bufotenine, bufotenidine, norpsilocin, 4-hydroxytryptamine, N,N,N-trimethyl-4-hydroxytryptamine, psilocybin, baeocystin, norbaeocystin, aeruginascin or any combination selected therefrom; and
the acidified solvent has a pH of 3.5 or lower and is a mixture of an acid and a solvent that is a C1-C4 primary aliphatic alcohol, a C3-C4 ketone, water or any combination selected therefrom;

filtering the slurry to obtain a psychoactive alkaloid liquid;
adjusting the pH of the psychoactive alkaloid liquid to a pH ranging from 3.5-4.5;
evaporating the solvent from the psychoactive alkaloid liquid to obtain a dephosphorylated psychoactive alkaloid extract comprising a psychoactive alkaloid that is psilocin, bufotenine, bufotenidine, norpsilocin, 4-hydroxytryptamine, N,N,N-trimethyl-4-hydroxytryptamine or any combination selected therefrom; and
mixing the dephosphorylated psychoactive alkaloid extract with a mucoadhesive polymer and one or more other excipients including a carrier.