Patent ID: 11957687
Assignee: REGENERON PHARMACEUTICALS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 4:
5. A compound according to formula (VI):, or a pharmaceutically acceptable salt thereof, wherein:
k, k′ are independently from 0 to 4;
X is a bond, —CH2, —CH2—CH2—, —CH2—O—, —CH═CH—, —(C═O)—, —O—, —NR#—, —S—, —(S═O)—, or —(SO2)—,
Y is N, —CR2, or —COR2;
R1 is H, —(CH2)0-3—NH2, —(CH2)0-3—NHR#, —(CH2)0-3—N(R#)2, C1-4 alkyl, C1-4 haloalkyl, phenyl, benzyl, or —(CH2)0-3—X—(CH2)0-3-phenyl, wherein phenyl is optionally substituted with one or more R5 groups;
R2 is H, halogen, —(CH2)0-3—NH2, —(CH2)0-3—NHR#, —(CH2)0-3—N(R#)2, C1-12 alkyl, C1-12 alkenyl, C6-12 aryl, C1-12 aralkyl, C1-12 arylalkyl, C1-4 haloalkyl, C3-7 cycloalkyl, or a 5-7-membered heterocycle with 1 to 4 heteroatoms independently selected from O, N and S or combinations thereof, any of which is optionally substituted by one or more of —OH, C1-4 alkyl, C1-4 alkoxy, ═O, phenyl, or benzyl;
R3 is H, C1-4 alkyl, or C1-4 haloalkyl; and wherein:
when Y is N, at least one or R1 , and R3 is not H, and when Y is CR2, at least one of R1, R2, and R3 is not H;

R5 is independently at each occurrence halogen, —CN, ═O, —OH, —NH2, —(CH2)1-3—OR#, —NH—(C═O)—R*, —NH—(C═O)O—R*, —NH—(SO2)—R*, —(CH2)1-3—NR#2, —NHR#, —N(R#)2, C1-4 alkoxy, phenoxy, C1-12 alkyl, C1-12 heteroalkyl comprising 1 to 3 hetero atoms selected from —O—, —S—, or —NH—, C1-12 alkenyl, C1-12 alkynyl, C1-4 haloalkyl, C1-4 haloalkoxy, C6-12 aryl, a 3-7-membered heterocycle with 1 to 4 heteroatoms selected from O, N and S or combinations thereof, or wherein two adjacent R5 groups form a 5-7 membered ring that optionally contains 1 to 3 heteroatoms selected from O, N, and S; any of which is optionally substituted with R*;
R* is halogen, —OH, C1-3 alkyl, C1-3 haloalkyl, phenyl, or benzyl, any of which is optionally substituted with a halogen; and
R# is C1-3 alkyl, C3-6 cycloalkyl, phenyl, or benzyl, any of which is optionally substituted with a halogen.