Patent ID: 11925653
Assignee: FLEURIR ABX, LLC
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 7:
8. A plurality of antimicrobial compounds or agents provided over a course for use in inhibiting growth of a microorganism, or killing the microorganism comprising:
at least three antimicrobial compounds or agents each provided daily over the course, the at least three antimicrobial compounds or agents comprising:
a fosfomycin as a pharmaceutically acceptable salt or ester, any of which have inhibitory activity on cell wall synthesis of the microorganism;
a sulfonamide as a pharmaceutically acceptable salt or ester, any of which have inhibitory activity on folic acid metabolism of the microorganism; and
a diaminopyrimidine as a pharmaceutically acceptable salt or ester, any of which inhibit dihydrofolate reductase in the microorganism,

such that the course of the at least three antimicrobial compounds or agents will inhibit growth of the microorganism or kill the microorganism by a synergistic activity of the at least three antimicrobial compounds or agents,
wherein over the course, the at least three antimicrobial compounds or agents in use display a broad spectrum activity against the microorganism, the microorganism selected from at least one of an aerobic Gram-positive bacteria, an aerobic Gram-negative bacteria, and a parasite, and
wherein the microorganism is further selected from any one or more of a drug-resistant aerobic bacteria, a multi-drug resistant aerobic bacteria, a drug-resistant parasite, and a multi-drug resistant parasite, any of which is causing or is suspected of causing an infection.