Patent ID: 11957687
Assignee: REGENERON PHARMACEUTICALS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 3:
4. A compound according to formula (V′), or a pharmaceutically acceptable salt thereof, wherein:
L is a bond, —(CH2)n—, —(CHB)n—, —CH2CHB—, or —CHBCH2—;
wherein;
B is benzyl or C1-12 alkyl optionally comprising 1-4 O atoms, either of which is optionally substituted by —OH or —OCH3;
n is 1 or 2; and wherein: and Ar are as defined above.
when Ar is phenyl, phenyl is optionally substituted by one or more R7 and not by R8; when L is —(CH2)n—, Ar is phenyl, then at least one R7 is a phenoxy that is optionally substituted with a halogen; and
when L is —(CHB)n—, B is C1-4 alkyl, Ar is phenyl, then R7 is present and is not —Cl, —F, —CN, C1-4 alkyl, or C1-4 alkoxy;

Ar is a phenyl, naphthyl, or a C4—C8 cycloalkyl, any of which is optionally substituted with one or more R8 or Het; 
Het is a 6-membered heterocycle comprising from 1 to 3 heteroatoms independently selected from N and O, wherein Het is optionally substituted with one or more of C1-3 alkyl, C1-3 alkenyl, halogen, —OH or ═O;
R7 is independently at each occurrence halogen, —CN, ═O, —OH, —(CH2)1-3—OR#, —NH—(C═O)—R*, —NH—(SO2)—R*, —(CH2)1-3—NR#2, —NHR#, —N(R#)2, C1-4alkoxy, phenoxy, C1-12 alkyl, C1-12 alkenyl, C1-4 haloalkyl, or C6-12 aryl, any of which is optionally substituted with R*;
R8 is independently at each occurrence halogen, —CN, ═O, —OH, —(CH2)0-3—SH, —(CH2)0-3—SR*, —(SO2)—R*, —NH2, —(CH2)1-3—OR#, —NH—(C═O)—R*, —NH—(SO2)—R*, —(CH2)1-3—NR#2, —NHR#, or —N(R#)2, C1-4 alkoxy, phenoxy, C1-12 alkyl, C1-12 alkenyl, C1-12 alkynyl, C1-4 haloalkyl, C1-4 haloalkoxy, C6-12 aryl, a 4-7 membered heterocycle with 1 to 4 heteroatoms selected from O, N and S or combinations thereof, or wherein two adjacent R8 groups form a 5-7 membered ring that optionally contains 1 to 3 heteroatoms selected from O, N, and S; any of which is optionally substituted with R*;
R* is halogen, —OH, C1-3 alkyl, C1-3 haloalkyl, phenyl, or benzyl, any of which is optionally substituted with a halogen; and
R# is C1-3 alkyl, C1-3 haloalkyl, C3-6 cycloalkyl, phenyl, or benzyl, any of which is optionally substituted with a halogen.