Patent ID: 11946935
Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTA
Field: Measurement (Instruments)
Classification: CPC G | IPC G

Claim 0:
1. A method to detect and treat a meningioma in a subject comprising obtaining a blood serum sample from a subject,
measuring a level of amphiregulin, CCL24, CD69, EGF, HB-EGF, caspase-3, VEGFD, TGF-α, BAFF, CCL9, and/or GH in said sample; and
comparing the level of amphiregulin, CCL24, CD69, EGF, HB-EGF, caspase-3, VEGF-D, TGF-α, BAFF, CCL9, and/or GH to a level of amphiregulin, CCL24, CD69, EGF, HB-EGF, caspase-3, VEGF-D, TGF-a, E-Selectin, BAFF, CCL9, and/or GH in a control serum sample,
wherein an increase in levels of amphiregulin, CCL24, CD69, EGF, HB-EGF, and/or caspase-3 and/or a decrease in levels of VEGF-D, TGF-α, BAFF, CCL9, and GH as compared to a control indicates a meningioma is present in said subject, and
administering to the subject with a meningioma a treatment, wherein the treatment comprises surgery, radiation, immunotherapy, chemotherapy or a combination thereof.