Patent ID: 11912647
Assignee: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION
Field: Organic fine chemistry (Chemistry)
Classification: CPC C | IPC C

Claim 0:
1. A method for producing a trisubstituted hydroxylamine, the method comprising reacting a monoperoxyacetal compound with a secondary amide, wherein the monoperoxyacetal compound has the structure I or II, , wherein
R1 is a substituted or unsubstituted linear or branched alkyl group, a substituted or unsubstituted cycloalkyl group or heterocycloalkyl group, a polyether group, an alkylpolyether group, or a protected or unprotected monosaccharide, disaccharide, or polysaccharide, and
R2 is hydrogen, an aryl group, a heteroaryl group, or a substituted or unsubstituted alkyl group; and
the secondary amide has the structure IV, , wherein
R5 and R6 are, independently, a substituted or unsubstituted alkyl group, a substituted or unsubstituted cycloalkyl group or heterocycloalkyl group, a substituted or unsubstituted aryl group, or a substituted or unsubstituted heteroaryl group, or wherein R5 and R6 together form a substituted or unsubstituted cycloalkyl group or heterocycloalkyl group, and
M+is Li, MgBr, MgCI, or Mgl, wherein the secondary amide is produced by reacting a secondary amine with a Grignard reagent or an alkyl lithium, and
wherein the trisubstituted hydroxylamine has the structure V, , wherein a molar ratio of monoperoxyacetal compound to the secondary amide is from 1:1 to 1:5.