Patent ID: 11964060
Assignee: LTS LOHMANN THERAPIE-SYSTEME AG
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 14:
15. A transdermal therapeutic system (TTS), comprising:
a) a transparent back layer impermeable to nicotine comprised of polyester;
b) an active-substance-containing layer comprising nicotine as active substance, wherein the nicotine is in the form of a free base and a vinylpyrrolidone-vinyl acetate copolymer, and wherein the weight ratio of nicotine to vinylpyrrolidone-vinyl acetate copolymer in the active substance-containing layer is 5:1 to 1:1, wherein the residual nicotine content at 24 hours of use on skin is at most 60% at room temperature;
c) a matrix layer comprised of a material selected from cationic copolymers based on dimethylaminoethyl methacrylate and neutral methacrylic esters, and neutral copolymers based on butyl methacrylate and methyl methacrylates; and
d) a detachable protective layer;
wherein a joint fraction comprising nicotine and the vinylpyrrolidone-vinyl acetate copolymer in the active-substance-containing layer is 90 to 100% by weight in relation to the weight of the active-substance-containing layer, wherein the transdermal therapeutic system contains 10 to 400 mg of nicotine, and wherein said TTS is transparent.