Patent ID: 11891388
Assignee: INCYTE CORPORATION
Field: Organic fine chemistry (Chemistry)
Classification: CPC C  A | IPC C

Claim 23:
24. The method of claim 1, wherein:
CyA is 5-10 membered heteroaryl; wherein the 5-membered heteroaryl has at least one ring-forming carbon atom and 1 or 2 ring-forming heteroatoms independently selected from N, O, and S and the 6-10 membered heteroaryl has at least one ring-forming carbon atom and 1, 2, 3, or 4 ring-forming heteroatoms independently selected from N, O, and S; wherein the N and S are optionally oxidized; wherein a ring-forming carbon atom of the 5-10 membered heteroaryl is optionally substituted by oxo to form a carbonyl group; and wherein the 5-10 membered heteroaryl is optionally substituted with 1, 2, 3 or 4 substituents independently selected from R20;
each R10 is independently selected from C1-6 alkyl, piperazinyl, piperidinyl, C(O)Rb1, and C(O)NRc1Rd1; wherein said C1-6 alkyl, piperazinyl, and piperidinyl are each optionally substituted with 1, 2, 3, or 4 substituents independently selected from R11;
each R11 is independently selected from C1-6 alkyl, ORa3, C(O)Rb3, and S(O)2Rb3;
each R20 is independently selected from C1-6 alkyl, C1-6 haloalkyl, C6-10 aryl, 5-10 membered heteroaryl, halo, CN, ORa2, C(O)NRc2Rd2, C(O)ORa2, NRc2Rd2, NRe2C(O)Rb2, and NRc2S(O)2Rb2; wherein said C1-6 alkyl, C6-10 aryl, and 5-10 membered heteroaryl are each optionally substituted with 1, 2, 3, or 4 substituents independently selected from R21;
or two adjacent R20 substituents on the CyA ring, taken together with the atoms to which they are attached, form a fused 5- or 6-membered heterocycloalkyl ring, or a fused C3-7 cycloalkyl ring; wherein each fused 5- or 6-membered heterocycloalkyl ring has at least one ring-forming carbon atom and 1, 2, 3, or 4 ring-forming heteroatoms independently selected from N, O, and S; wherein a ring-forming carbon atom of each fused 5- or 6-membered heterocycloalkyl ring is optionally substituted by oxo to form a carbonyl group; and wherein the fused 5- or 6-membered heterocycloalkyl ring and fused C3-6 cycloalkyl ring are each optionally substituted with 1, 2, 3 or 4 substituents independently selected from R21;
each R21 is independently selected from C6-10 aryl, 5-10 membered heteroaryl, ORa4, and NRc4Rd4, each R22 is ORa6, each Rc1 and Rd1 is independently selected from H, C1-6 alkyl, 4-10 membered heterocycloalkyl, and C6-10 aryl; wherein said C1-6 alkyl, 4-10 membered heterocycloalkyl and C6-10 aryl are each optionally substituted with 1, 2, 3, or 4 substituents independently selected from R11;
or any Rc1 and Rd1 attached to the same N atom, together with the N atom to which they are attached, form a 4-, 5-, 6- or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from R11;
Rb1 is 4-10 membered heterocycloalkyl optionally substituted with 1, 2, 3, or 4 substituents independently selected from R11;
each Ra2, Rc2 and Rd2 is independently H or C1-6 alkyl; wherein said C1-6 alkyl is optionally substituted with 1, 2, 3, or 4 substituents independently selected from R21;
each Rb2 is C1-6 alkyl;
each Rb3 is C1-6 alkyl;
each Ra3 is independently H or C1-6 alkyl;
each Ra4, Rc4 and Rd4 is H or C1-6 alkyl; wherein said C1-6 alkyl is optionally substituted with 1, 2, 3, or 4 substituents independently selected from R22; and
Ra6 is H.