Patent ID: 11883428
Assignee: LPOXY THERAPEUTICS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C  Y | IPC A  C

Claim 9:
10. An oral formulation in solid form for treating an intestinal anaerobic bacterial infection, comprising:
at least one agent that delivers oxygen or acts as a source of oxygen in an intestine when administered to a subject,
wherein said at least one agent is in a solid form,
a catalyst, a first controlled release coating encasing the agent, a second controlled release coating encasing the catalyst and the encased agent, a porous cellulose membrane encapsulating the catalyst and the agent,
wherein the porous cellulose membrane comprises two or more layers of cellulose having a functional pore size smaller than an actual pore size, wherein the actual pore size restricts diffusion of molecules greater than 10 kilodaltons, which thereby prevents a majority of the catalyst from diffusing across the membrane,
wherein the pore size is sufficient to allow water to diffuse across any portion of the membrane to contact the agent and to allow oxygen to diffuse across any portion of the membrane into an intestine of the subject, and

an enteric coating surrounding the oral formulation, and
wherein the oxygen is capable of creating an aerobic environment in the intestine sufficient to treat the anaerobic bacterial infection by reducing a population of anaerobic bacteria.