Patent ID: 11925654
Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 0:
1. A method of treating a proliferative disease chosen from squamous cell carcinoma and lung adenocarcinoma by inhibiting glycolysis in glycolytic tumor cells in a patient in need thereof comprising administering a therapeutically effective amount of one or more compounds of the Formula I:, or a salt, ester or prodrug thereof, wherein:
each R1, R2, R3 and R4 are independently H, or COR5;
at least one of R1, R2, R3 and R4 is COR5; and
each R5 is independently selected from the group C3-C10 straight- or branched-chain alkyl, C4-C10 alkylcycloalkyl, and C3-C10 cycloalkyl.