Patent ID: 11872277
Assignee: THE SCRIPPS RESEARCH INSTITUTE
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 5:
6. A polynucleotide encoding an engineered Ebolavirus glycoprotein (GP) protein that comprises (a) a truncated soluble GP of an Ebolavirus that has the mucin-like domain (MLD) deleted from the GP1 subunit and the membrane proximal external region (MPER) deleted from the GP2 subunit, and (b) substitution of residue W615 in heptad repeat 2 (HR2) with residue L, A, V, I or F; wherein the amino acid numbering is based on Zaire Ebolavirus GP sequence corresponding to UniProt ID Q05320 (SEQ ID NO:1).