Patent ID: 11912734
Assignee: THE JOHNS HOPKINS UNIVERSITY
Field: Organic fine chemistry (Chemistry)
Classification: CPC C | IPC C

Claim 0:
1. A method for synthesizing an oligonucleotide, the method comprising:
(a) providing a nucleoside phosphoramidite comprising a 2′-deoxyribose moiety having a 3′-hydroxyl position and a 5′-hydroxyl position, wherein the nucleoside phosphoramidite has a dimethoxytrityl protecting group at the 3′-hydroxyl position and a phosphoramidite moiety at the 5′-hydroxyl position, wherein the nucleoside phosphoramidite has the following structure:, and
(b) contacting the nucleoside phosphoramidite of (a) with one or more nucleoside residues attached to a solid phase support to form a solid support-bound product.