Patent ID: 11919956
Assignee: XENCOR, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A heterodimeric antibody comprising:
a) a first monomer comprising, from N-terminus to C-terminus, a VH1-CH1-linker 1-scFv-linker 2-CH2-CH3,
wherein VH1 is a first variable heavy domain, scFv is an anti-CD3 scFV, linker 1 and linker 2 are a first domain linker and second domain linker, respectively, and CH2-CH3 is a first Fc domain;
b) a second monomer comprising, from N-terminus to C-terminus, a VH2-CH1-hinge-CH2-CH3, wherein VH2 is a second variable heavy domain and CH2-CH3 is a second Fc domain; and
c) a first common light chain comprising a first variable light domain (VL1) and a light chain constant domain; and
d) a second common light chain comprising a second variable light domain (VL2) and a light chain constant domain,
wherein the first variable heavy domain and the first variable light domain form a first PSMA binding domain, and the second variable heavy domain and the second variable light domain form a second PSMA binding domain,
wherein the VH1 and VH2 each comprise the vhCDR1, vhCDR2 and vhCDR3 of a variable heavy domain having an amino acid sequence of SEQ ID NO: 217; and the VL1 and VL2 each comprise the vlCDR1, vlCDR2 and vlCDR3 of a variable light domain having an amino acid sequences of one of the following: SEQ ID NO: 252, SEQ ID NO: 257, and SEQ ID NO: 286.