Patent ID: 11965880
Assignee: SOMALOGIC OPERATING CO., INC.
Field: Measurement (Instruments)
Classification: CPC C  G | IPC C  G

Claim 16:
17. A method for detecting a target protein in a biological sample, comprising:
capturing the target protein with an aptamer by combining the biological sample with a plurality of aptamers each configured to capture a specific protein;
forming a tri-molecular complex including:
the aptamer that captured the target protein,
a first probe including a portion hybridized to a corresponding first portion of the aptamer that captured the target protein, and
a second probe including a portion hybridized to a corresponding second portion of the aptamer that captured the target protein, at least one DNA primer region, and an aptamer ID sequence corresponding to the aptamer that captured the target protein;
amplifying the aptamer ID sequence of the second probe; and
sequencing the amplified aptamer ID sequence of the second probe to identify the aptamer ID sequence of the second probe, thereby identifying the aptamer that captured the target protein and identifying the target protein.