Patent ID: 11905297
Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 0:
1. A compound of formula (A):, or a pharmaceutically acceptable salt thereof, wherein:
Y1, Y2, Y3, and Y4, are each independently N or CR6, wherein no more than two of Y1, Y2, Y3, and Y4 are N;
W1 and W2 are each independently selected from aryl, heterocyclyl, or heteroaryl, which are each optionally substituted with one or more R10;
-L1-W1 is —CHR7CH2—W1;
L2 is C1-C6 alkylene or C2-C6 alkenylene, optionally substituted with one or more R8;
R2 is O, NH, or NR11;
R6 is hydrogen, halogen, —CN, —NO2, —SC1-C6 alkyl, —CORg, —C1-C6 alkyl, —C3-C6 cycloalkyl, C1-C6 haloalkyl, C1-C6 alkoxy, or —C1-C6 haloalkoxy,
R7 is halogen, —OH, —NRaRb, —CN, —C1-C6 alkyl, —C1-C3 alkylene-OH, —C1-C3 alkylene-CN, —CH(OH)CH2CN, —C1-C3 alkylene-(C1-C6 alkoxy), —C1-C3 alkylene-(C1-C6 haloalkoxy), —C1-C3 alkylene-OCO(optionally substituted heterocyclyl), —C1-C3 alkylene-OCOR9, —C1-C3 alkylene-OCOORg, —C1-C3 alkylene-NRaRb, —C1-C3 alkylene-NRaCOR9, —C1-C3 alkylene-NRaCO(optionally substituted heterocyclyl), —C1-C3 alkylene-NRaCOORg, —C1-C3 alkylene-NRaCONRaRb, —C1-C3 alkylene-CONRaRb, —C1-C3 alkylene-CONRcRd, —CONRaRb, —CONRcRd, —(C1-C3 alkylene)-O—(C1-C3 alkylene)-OH, —(C1-C3 alkylene)-O—(C1-C3 alkylene)-CN, —(C1-C3 alkylene)-O—(C1-C3 alkylene)-O—(C1-C4 alkyl), —(C1-C3 alkylene)-O—(C1-C3 alkylene)-O—(C1-C4 haloalkyl), —(C1-C3 alkylene)-O—(C1-C3 alkylene)-S—(C1-C3 alkyl), —C1-C3 alkylene-S(C1-C6 alkyl), —C1-C3 alkylene-SO(C1-C6 alkyl), —C1-C3 alkylene-SO2(C1-C6 alkyl), —C1-C3 alkylene-SO2R12, or heterocyclyl optionally substituted with R10;
R8 is —OH, —CN, —NO2, —CORg, oxo, —C1-C6 alkyl, C1-C6 alkylene-OH, —C1-C6 haloalkyl, or —C3-C6 cycloalkyl;
Ra and Rb are each independently H, —C1-C6 alkyl, —C1-C6 haloalkyl, —CHO, —COOH, —CO(C1-C3 alkyl), —CO(C1-C3 haloalkyl), —CO(C3-C8 cycloalkyl), —CO(C2-C4 alkenyl), —CO(C1-C6 alkylene)-OH, —CO(C1-C6 alkylene)-(C1-C6 alkoxy), —CONReRf, —CO(C1-C3 alkylene)-NReRf, —CO(C1-C3 alkylene)-NReSRf, —CO(C1-C3 alkylene)-NReSORg, —CO(C1-C3 alkylene)-NReSO2Rf, —CO(C2-C3 alkenyl), —CO(C1-C3 haloalkyl), —CO(CH2)n(cycloalkyl), —CO(CH2)n(optionally substituted aryl), —CO(CH2)n(optionally substituted heterocyclyl), or —CO(CH2)n(optionally substituted heteroaryl);
Rc and Rd together with the nitrogen atom to which it is attached to form an optionally substituted ring, which can be monocyclic, fused bicyclic, or spiral bicyclic, wherein the ring can contain up to 3 heteroatoms selected from N, O, or S;
Re and Rf are each independently H, —C1-C6 alkyl, —C1-C6 haloalkyl, or —C1-C6 alkylene-OH;
Rg is H, —C1-C6 alkyl, —C3-C6 cycloalkyl, —C1-C6 haloalkyl, phenyl, or benzyl;
R9 is —C1-C3 alkylene-OH, —C1-C3 alkylene-CN, —C1-C3 alkylene-(C1-C3 alkoxy), —C1-C3 alkylene-NRaRb, —C1-C4 alkyl or —C1-C4 fluoroalkyl;
R10 is halogen, —CN, oxo, —C1-C6 alkyl, —C1-C6 haloalkyl, —C1-C6 alkoxy, —C1-C6 haloalkoxy, —S—S—(C1-C6 alkyl), or optionally substituted phenyl;
R11 is —C1-C6 alkyl, —C1-C6 haloalkyl, —C1-C6 alkoxy, —C1-C3 alkylene-OH, —C1-C3 alkylene-(C1-C3 alkoxy), or —COO(C1-C6 alkyl);
alternatively, R11 and R7 together form a 5- to 7-membered ring, which is optionally substituted with R10;
R12 is —OH, —C1-C6 alkyl, —C3-C6 cycloalkyl, —C1-C6 haloalkyl, —C1-C6 alkoxy, phenyl, benzyl, —NRaRb, —CONRaRb, or —NRaCORg; and
n is 0, 1, or 2.