Patent ID: 11920130
Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC C

Claim 7:
8. The method of claim 7, wherein the endogenous transcriptional modulator is:
(a) the PAGR1 gene and the guide RNA comprises a nucleic acid sequence set forth in any one of SEQ ID NOs: 31-36;
(b) the SIX2 gene and the guide RNA comprises a nucleic acid sequence set forth in any one of SEQ ID NOs:37-42;
(c) the Klf4 gene and the guide RNA comprises a nucleic acid sequence set forth in any one of SEQ ID NOs:43-48;
(d) the USP27X gene and the guide RNA comprises a nucleic acid sequence set forth in any one of SEQ ID NOs:49-54;
(e) the CEACAM19 gene and the guide RNA comprises a nucleic acid sequence set forth in any one of SEQ ID NOs:55-60; or
(f) the Clorfl4l gene and the guide RNA comprises a nucleic acid sequence set forth in any one of SEQ ID NOs:61-66.