Patent ID: 11883535
Assignee: NORTHWESTERN UNIVERSITY
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 0:
1. A liposomal particle having a substantially spherical geometry, comprising:
a lipid bilayer comprising a plurality of lipid groups; and single-stranded oligonucleotides that are inhibitory RNA or antisense DNA, wherein all the oligonucleotides are attached to the surface of the liposomal particle, wherein each oligonucleotide is an oligonucleotide-lipid conjugate containing one lipophilic tethered group anchored into the external side of the lipid bilayer, wherein one or more of the oligonucleotides hybridize to a gene comprising a polynucleotide encoding a gene product and are complementary to all or a portion of the polynucleotide, wherein the hybridizing between the oligonucleotide and the polynucleotide occurs over a length of the polynucleotide with a degree of complementarity sufficient to inhibit expression of the gene product, and wherein the diameter of the liposomal particle is less than or equal to 50 nanometers (nm).