Patent ID: 11866503
Assignee: REGENERON PHARMACEUTICALS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A method for treating an inflammatory disease or disorder of the airway or lungs of a subject in need thereof, or at least one symptom associated with the inflammatory disease or disorder of the airway or lungs of the subject, the method comprising administering to the subject one or more doses of a therapeutically effective amount of an interleukin-33 (IL-33) antagonist in combination with one or more doses of a therapeutically effective amount of an interleukin-4 receptor (IL-4R) antagonist, wherein the IL-33 antagonist is a monoclonal antibody comprising three heavy chain complementarity determining regions, HCDR1, HCDR2, and HCDR3, comprising the amino acid sequences of SEQ ID NOs: 276, 278, and 280, respectively, and a heavy chain variable region (HCVR) comprising an amino acid sequence with 10 or fewer amino acid substitutions relative to SEQ ID NO: 274, and three light chain complementarity determining regions, LCDR1, LCDR2, and LCDR3, comprising the amino acid sequences of SEQ ID NOs: 284, 286, and 288, respectively, and a light chain variable region (LCVR) comprising an amino acid sequence with 10 or fewer amino acid substitutions relative to SEQ ID NO: 282, and wherein the IL-4R antagonist is a monoclonal antibody comprising three heavy chain complementarity determining regions, HCDR1, HCDR2, and HCDR3, comprising the amino acid sequences of SEQ ID NOs: 339, 340, and 341, respectively, and a HCVR comprising an amino acid sequence with 10 or fewer amino acid substitutions relative to SEQ ID NO: 337, and three light chain complementarity determining regions, LCDR1, LCDR2, and LCDR3, comprising the amino acid sequences of SEQ ID NOs: 342, 343, and 344, respectively, and a LCVR comprising an amino acid sequence with 10 or fewer amino acid substitutions relative to SEQ ID NO: 338.