Patent ID: 11926629
Assignee: KING FAISAL UNIVERSITY
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A compound having the formula I:, , or a pharmaceutically acceptable salt, ester, stereoisomer, or solvate thereof, wherein:
R1 is selected from the group consisting of hydrogen, a C1-C6 straight chain alkyl, a C1-C6 branched alkyl, and a C3-C6 cycloalkyl; and
R2 is selected from the group consisting of —NHAr, —NHCOAr, —NHSO2Ar, —NHCH2Ar, —NHCH2CH2Ar, —NHCH2CH2NHR3, —NHCH2CH2NR3R4, —NHCH2CH2CH2NHR3, —NHCH2CH2CH2NR3R4, —NHCOCH2CH2NHR3, —NHCOCH2CH2NR3R4, —NHCOCH2CH2CH2NHR3, —NHCOCH2CH2CH2NR3R4, —NHSO2CH2CH2NHR3, —NHSO2CH2CH2NR3R4, —NHSO2CH2CH2CH2NHR3, —NHSO2CH2CH2CH2NR3R4, Ar, —CH2Ar, —CH2CH2Ar, —COAr, —SO2Ar, —COCH2CH2NHR3, —COCH2CH2NR3R4, —COCH2CH2CH2NHR3, —COCH2CH2CH2NR3R4, —SO2CH2CH2NHR3, —SO2CH2CH2NR3R4, —SO2CH2CH2CH2NHR3, —SO2CH2CH2CH2NR3R4, a C1-C6 straight chain alkyl, a C1-C6 branched alkyl, a C3-C6 cycloalkyl, a halo-C1-C6 straight chain alkyl, a halo-C1-C6 branched alkyl, a halo-C3-C6 cycloalkyl, a cyano-C1-C6 straight chain alkyl, a cyano-C1-C6 branched alkyl, and a cyano-C3-C6 cycloalkyl;
Ar is an aryl ring or a 5 or 6 membered heteroaryl ring, either of the aryl ring or the heteroaryl ring being optionally substituted with one or more substituents selected from the group consisting of halogen, cyano, —OH, —OR3, —NH2, —NHR3, —NR3R4, —CONH2, —CONHR3, —CONR3R4, —SO2NH2, —SO2NHR3, —SO2NR3R4, —NHCOR3, —NHCO2R3, —NHCONHR3, —NHSO2NHR3, —NHSO2R3, —COR3, —CO2R3, a C1-C6 straight chain alkyl, a C1-C6 branched alkyl, a C3-C6 cycloalkyl, a halo-C1-C6 straight chain alkyl, a halo-C1-C6 branched alkyl, a halo-C3-C6 cycloalkyl, a cyano-C1-C6 straight chain alkyl, a cyano-C1-C6 branched chain alkyl, and a cyano-C3-C6 cycloalkyl; and
R3 and R4 are each independently selected from the group consisting of hydrogen, a C1-C6 straight chain alkyl, a C1-C6 branched alkyl, a C3-C6 cycloalkyl, a halo-C1-C6 straight chain alkyl, a halo-C1-C6 branched alkyl, a halo-C3-C6 cycloalkyl, a cyano-C1-C6 straight chain alkyl, a cyano-C1-C6 branched alkyl, a cyano-C3-C6 cycloalkyl, a substituted aryl ring, and a substituted heteroaryl ring, or wherein R3 and R4, together with a nitrogen atom to which they are attached, form a nitrogen-containing heterocycle, such nitrogen-containing heterocycle being optionally substituted with from one to three substituents independently selected from the group consisting of a straight or branched C1-C6 alkyl group, a halogen atom, a straight or branched C1-C6 alkoxy group, a straight or branched C1-C6 trihaloalkyl group, and a hydroxy group.