Patent ID: 11897962
Assignee: MEMORIAL SLOAN KETTERING CANCER CENTER
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A  G  Y | IPC A  C  G

Claim 8:
9. An isolated antibody that specifically binds to human GITR comprising a VH CDR1, a VH CDR2, a VH CDR3, a VL CDR1, a VL CDR2, and a VL CDR3 comprising the amino acid sequences of SEQ ID NOs: 19, 24, 34, 101, 105, and 106; 19, 25, 34, 102, 105, and 107; 19, 26, 34, 102, 105, and 107; 20, 27, 34, 103, 105, and 108; 21, 28, 34, 101, 105, and 107; 22, 29, 34, 103, 105, and 109; 21, 24, 34, 101, 105, and 109; 21, 177, 34, 103, 105, and 107; 23, 31, 34, 104, 105, and 107; 19, 32, 34, 103, 105, and 107; 22, 29, 34, 102, 105, and 107; 22, 29, 34, 101, 105, and 107; 22, 29, 34, 103, 105, and 107; 22, 33, 34, 102, 105, and 107; 22, 33, 34, 101, 105, and 107; 22, 33, 34, 103, 105, and 107; 19, 24, 34, 102, 105, and 107; 22, 121, 34, 103, 105, and 109; 23, 187, 34, 102, 105, and 107; 22, 148, 34, 101, 105, and 108; 119, 181, 34, 101, 105, and 109; 23, 124, 34, 104, 105, and 107; 22, 151, 34, 103, 105, and 108; 23, 135, 34, 101, 105, and 107; 20, 132, 34, 104, 105, and 108; 116, 152, 34, 102, 105, and 106; 19, 144, 34, 102, 105, and 109; 23, 148, 34, 104, 105, and 107; 117, 148, 34, 104, 105, and 109; 19, 164, 34, 101, 105, and 109; 19, 127, 34, 103, 105, and 109; 119, 146, 34, 101, 105, and 107; 21, 162, 34, 101, 105, and 107; 19, 140, 34, 102, 105, and 107; 23, 157, 34, 101, 105, and 108; 19, 130, 34, 103, 105, and 107; 19, 145, 34, 104, 105, and 109; 21, 114, 34, 102, 105, and 107; 19, 127, 34, 101, 105, and 192; 117, 151, 34, 103, 105, and 109; 23, 138, 34, 102, 105, and 109; 22, 123, 34, 102, 105, and 108; 21, 148, 34, 104, 105, and 109; 21, 32, 34, 101, 105, and 109; 21, 172, 34, 104, 105, and 107; 35, 165, 34, 101, 105, and 107; 23, 133, 34, 103, 105, and 107; 21, 171, 34, 102, 105, and 107; 21, 32, 34, 103, 105, and 107; 21, 168, 34, 103, 105, and 109; 23, 129, 34, 102, 105, and 106; 23, 174, 34, 101, 105, and 106; 35, 170, 34, 102, 105, and 107; 23, 123, 34, 102, 105, and 107; 22, 142, 34, 102, 105, and 108; 23, 147, 34, 101, 105, and 109; 23, 122, 34, 101, 105, and 107; 21, 149, 34, 101, 105, and 108; 19, 179, 34, 102, 105, and 109; 21, 134, 34, 103, 105, and 107; 23, 172, 34, 102, 105, and 192; 21, 27, 34, 102, 105, and 109; 22, 182, 34, 101, 105, and 107; 21, 177, 34, 104, 105, and 107; 19, 143, 34, 104, 105, and 107; 21, 186, 34, 101, 105, and 107; 21, 153, 34, 102, 105, and 106; 22, 115, 34, 101, 105, and 109; 116, 167, 34, 102, 105, and 108; 23, 163, 34, 101, 105, and 109; 21, 180, 34, 104, 105, and 106; 23, 26, 34, 104, 105, and 108; 35, 183, 34, 104, 105, and 109; 23, 156, 34, 102, 105, and 109; 19, 151, 34, 102, 105, and 107; 118, 169, 34, 103, 105, and 109; 19, 178, 34, 101, 105, and 109; 19, 32, 34, 103, 105, and 107; 19, 175, 34, 102, 105, and 108; 119, 120, 34, 102, 105, and 109; 21, 154, 34, 101, 105, and 1007; 19, 187, 34, 101, 105, and 107; 117, 125, 34, 101, 105, and 109; 21, 155, 34, 102, 105, and 107; 22, 150, 34, 102, 105, and 107; 22, 126, 34, 103, 105, and 109; 21, 128, 34, 104, 105, and 107; 119, 170, 34, 104, 105, and 107; 19, 161, 34, 103, 105, and 109; 19, 127, 34, 103, 105, and 109; 23, 185, 34, 104, 105, and 107; 23, 188, 34, 102, 105, and 107; 19, 159, 34, 102, 105, and 107; 22, 177, 34, 102, 105, and 109; 19, 25, 34, 102, 105, and 109; 23, 141, 34, 101, 105, and 193; 22, 115, 34, 101, 105, and 108; 23, 139, 34, 102, 105, and 107; 117, 158, 34, 103, 105, and 107; 19, 173, 34, 102, 105, and 107; 21, 148, 34, 102, 105, and 109; 23, 184, 34, 104, 105, and 107; 22, 131, 34, 102, 105, and 108; 20, 166, 34, 101, 105, and 107; 117, 122, 34, 102, 105, and 109; 22, 167, 34, 101, 105, and 192; 117, 136, 34, 103, 105, and 109; 19, 194, 34, 104, 105, and 107; 19, 177, 34, 104, 105, and 192; 21, 137, 34, 101, 105, and 106; 23, 135, 34, 101, 105, and 107; 21, 160, 34, 103, 105, and 107; 19, 176, 34, 101, 105, and 107, respectively.