Patent ID: 11971410
Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
Field: Measurement (Instruments)
Classification: CPC G  C  A | IPC C  G

Claim 0:
1. A method of treating a subject with an immunotherapeutic, the method comprising the steps of:
contacting a biological sample comprising antibodies from a subject to a frameshift array comprising a plurality of tumor-associated frameshift peptides, wherein the plurality of tumor-associated frameshift peptides comprise frameshift peptides derived from indels arising during RNA transcription or from mis-splicing of exons;
measuring binding of antibodies having affinity to one or more of the tumor-associated frameshift peptides in the contacted biological sample;
for each of the plurality of tumor-associated frameshift peptides, quantifying levels of binding of the antibodies having affinity to one or more of the tumor-associated frameshift peptides to form a frameshift signature of the subject,
wherein the quantified levels of binding are indicative of whether the subject is likely to experience an immune-related adverse event in response to treatment of an immunotherapeutic; and
treating the subject with the immunotherapeutic.