Patent ID: 11918652
Assignee: NANOBACTERIE
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  G | IPC A  G

Claim 0:
1. A method of medically treating a body part of an individual with an acoustic wave, consisting of:
administering nanoparticles, optionally having a compound attached thereto, to the individual, said nanoparticles being located in a nanoparticle region selected from the group consisting of: i) a portion the body part, ii) a volume occupied by the nanoparticles in the body part, and iii) a volume occupied by the nanoparticles outside of the body part;
applying the acoustic wave on the body part after administering the nanoparticles to the nanoparticle region, wherein the application of the acoustic wave increases an initial temperature of the body part to a temperature and corresponds to a temperature increase of the body part that has at least one property selected from the group consisting of:
(i) the temperature increase of the body part is between 1 and 30° C.,
(ii) the temperature increase of the body part is lower than 30° C., wherein the temperature increase of the body part is equal to TNPBP minus TBP, where TNPBP is the temperature or the temperature increase of the body part of which the nanoparticles are exposed to the acoustic waves, and TBP is the temperature or temperature increase of the body part of which the nanoparticles are not exposed to the acoustic waves or the temperature or temperature increase of the body part not comprising the nanoparticles not exposed to the acoustic waves,, wherein the application of the acoustic wave is part of at least one session, each session consists of
more than one sequence of application of the acoustic wave, each sequence consisting of:
a) an application of the acoustic wave for a time t1; followed by non-application of the acoustic wave a time t2, wherein the time t2 is sufficiently short so that the temperature of the body part does not return to the initial temperature wherein the time t1 is longer than one second, or
b) an application of an acoustic wave during a time t1 followed by an application of another acoustic wave during a time t3, wherein the acoustic wave applied during the time t3 has an intensity, a power, an energy, or a frequency lower than an intensity, a power, an energy or a frequency of the acoustic wave applied during the time t1,, wherein the time t1 is longer than 1 second, wherein t3 is sufficiently short so that the temperature of the body part does not return to the initial temperature,, wherein a time lapse separating each session is longer than t1, t2, t3, t1+t2, or t1+t3,
wherein the acoustic wave has at least one property selected from the group consisting of:
a) an intensity, power or power density that is lower than 103 Watt, or Watt per a unit selected from the group consisting of: i) length or cm, ii) surface area or cm2, iii) volume or cm3, iv) length or cm of body part, v) surface area or cm2 of body part, vi) volume or cm3 of body part, vii) length or cm of transducer, viii) surface area or cm2 of transducer, and ix) volume or cm3 of transducer,
b) an intensity, a power or power density lower than 106 W per gram of nanoparticles,
c) an energy or energy density that is lower than 109 W·sec or J, or W·sec or J per a unit selected from the group consisting of: i) length or cm, ii) surface area or cm2, iii) volume or cm3, iv) length or cm of body part, v) surface area or cm2 of body part, vi) volume or cm3 of body part, vii) length or cm of transducer, viii) surface area or cm2 of transducer, ix) mass or gram of nanoparticles, and x) volume or cm2 of transducer, and
d) a frequency between 0.01 and 100 MHz.