Patent ID: 11912760
Assignee: PHAROSGEN CO., LTD
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A  G | IPC A  C  G

Claim 1:
2. A doppel-targeting molecule that binds to doppel, wherein the doppel targeting molecule comprises a heavy chain variable region and a light chain variable region, wherein:
(a) the heavy chain variable regions comprises the amino acid sequence of SEQ ID NO: 134 and the light chain variable region comprises the amino acid sequence of SEQ ID NO: 115;
(b) the heavy chain variable regions comprises the amino acid sequence of SEQ ID NO: 135 and the light chain variable region comprises the amino acid sequence of SEQ ID NO: 116;
(c) the heavy chain variable regions comprises the amino acid sequence of SEQ ID NO: 136 and the light chain variable region comprises the amino acid sequence of SEQ ID NO: 117;
(d) the heavy chain variable regions comprises the amino acid sequence of SEQ ID NO: 137 and the light chain variable region comprises the amino acid sequence of SEQ ID NO: 118;
(e) the heavy chain variable regions comprises the amino acid sequence of SEQ ID NO: 138 and the light chain variable region comprises the amino acid sequence of SEQ ID NO: 119;
(f) the heavy chain variable regions comprises the amino acid sequence of SEQ ID NO: 139 and the light chain variable region comprises the amino acid sequence of SEQ ID NO: 120;
(g) the heavy chain variable regions comprises the amino acid sequence of SEQ ID NO: 140 and the light chain variable region comprises the amino acid sequence of SEQ ID NO: 121;
(h) the heavy chain variable regions comprises the amino acid sequence of SEQ ID NO: 141 and the light chain variable region comprises the amino acid sequence of SEQ ID NO: 122;
(i) the heavy chain variable regions comprises the amino acid sequence of SEQ ID NO: 142 and the light chain variable region comprises the amino acid sequence of SEQ ID NO: 123;
(j) the heavy chain variable regions comprises the amino acid sequence of SEQ ID NO: 143 and the light chain variable region comprises the amino acid sequence of SEQ ID NO: 124;
(k) the heavy chain variable regions comprises the amino acid sequence of SEQ ID NO: 144 and the light chain variable region comprises the amino acid sequence of SEQ ID NO: 125;
(1) the heavy chain variable regions comprises the amino acid sequence of SEQ ID NO: 145 and the light chain variable region comprises the amino acid sequence of SEQ ID NO: 126;
(m) the heavy chain variable regions comprises the amino acid sequence of SEQ ID NO: 146 and the light chain variable region comprises the amino acid sequence of SEQ ID NO: 127;
(n) the heavy chain variable regions comprises the amino acid sequence of SEQ ID NO: 147 and the light chain variable region comprises the amino acid sequence of SEQ ID NO: 128;
(o) the heavy chain variable regions comprises the amino acid sequence of SEQ ID NO: 148 and the light chain variable region comprises the amino acid sequence of SEQ ID NO: 129;
(p) the heavy chain variable regions comprises the amino acid sequence of SEQ ID NO: 149 and the light chain variable region comprises the amino acid sequence of SEQ ID NO: 130;
(q) the heavy chain variable regions comprises the amino acid sequence of SEQ ID NO: 150 and the light chain variable region comprises the amino acid sequence of SEQ ID NO: 131;
(r) the heavy chain variable regions comprises the amino acid sequence of SEQ ID NO: 151 and the light chain variable region comprises the amino acid sequence of SEQ ID NO: 132; or
(s) the heavy chain variable regions comprises the amino acid sequence of SEQ ID NO: 152 and the light chain variable region comprises the amino acid sequence of SEQ ID NO: 133;
and doppel-binding fragments of any thereof.