Patent ID: 11896606
Assignee: HIGHLIGHT THERAPEUTICS, S.L.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 16:
17. A method for preparing an aqueous composition comprising the one or more particles of claim 1, comprising:
(a) preparing a first aqueous solution of at least one double-stranded polyribonucleotide, or a salt or solvate thereof, and a second aqueous solution of at least one polyalkyleneimine, or a salt or solvate thereof;
(b) independently filtering each respective first and second aqueous solution through a filter having a pore diameter of less than or equal to 500 nm thereby forming a corresponding first and second sterilized solution;
(c) mixing each resulting first and second sterilized solution in a mixing chamber thereby forming the aqueous composition,
(i) wherein one of the respective first and second sterilized solutions is introduced into the other respective sterilized solution in the mixing chamber, optionally by injection, at a rate of greater than or equal to 1 ml/min, or
(ii) wherein each respective first and second sterilized solution is introduced into the mixing chamber simultaneously, optionally by injection, at a rate of greater than or equal to 1 ml/min.