Patent ID: 11926596
Assignee: KADMON CORPORATION, LLC
Field: Organic fine chemistry (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 1:
2. A compound having the formula VI:, wherein:
R1 is selected from the group consisting of lower alkyl, C3-C6 cycloalkyl, substituted C3-C6 cycloalkyl, R10O(CR12R13)c—, W(CR12R13)d— and R10R11N—C(═O)—(CR12R13)c—;
each R10 is independently selected from lower alkyl and C3-C6 cycloalkyl;
each R11 is independently selected from lower alkyl and C3-C6 cycloalkyl;
each R12 is independently selected from H and lower alkyl;
each R13 is independently selected from H and lower alkyl;
additionally or alternatively, an R12 and an R13 attached to the same carbon atom may be taken together to form a C3-C6 cycloalkyl group;
W is a 3- to 7-membered heterocyclic ring having 1 to 3 ring heteroatoms;
c is 2 to 4;
dis 1 to 4;

R3 is selected from H, lower alkyl, substituted lower alkyl, and RR′N—(C2-4 alkyl)-;
R4 is selected from the group consisting of H, halo, hydroxy, lower alkyl, lower alkoxy, nitro, cyano, C1-C3 perfluoro alkyl, C1-C3 perfluoro alkoxy, carboxyl, RR′N—, RR′NCO—, RCONH—, RCONR′—, RR′N—(C2-4 alkyl)-, and RR′N—(C2-4 alkyl)-O—;
b is 0 to 2;
each R21 is independently selected from the group consisting of H, halo, hydroxy, lower alkyl, lower alkoxy, nitro, cyano, C1-C3 perfluoro alkyl, C1-C3 perfluoro alkoxy, carboxyl, RR′N—, RR′NCO—, RCONH—, RCONR′—, RO2C—, aryl-O— and heteroaryl-O—; and
n is 0 to 3;
each R and R′ is independently selected from H, lower alkyl, and C3-C6 cycloalkyl, or alternatively, R and R′ taken together form a 5 to 6 membered heterocyclic ring;
wherein substituted lower alkyl is a C1-4 alkyl having from one to three substituents independently selected from halo, hydroxy, lower alkoxy, amino, nitro, cyano, perfluoro lower alkyl, perfluoro lower alkoxy and carboxyl;
and
wherein substituted C3-C6 cycloalkyl is a C3-C6 cycloalkyl having from one to three substituents independently selected from halo, hydroxy, lower alkyl, lower alkoxy, amino, nitro, cyano, perfluoro lower alkyl, perfluoro lower alkoxy and carboxyl;
or a pharmaceutically acceptable salt thereof.