Patent ID: 11873289
Assignee: MYOKARDIA, INC.
Field: Organic fine chemistry (Chemistry)
Classification: CPC A  C  B  Y | IPC B  C

Claim 1:
2. A process for preparation of a compound of formula II, , wherein R2 is F, C1-C4 alkyl, or C1-C4 haloalkyl,
R3 is H, F, C1-C4 alkyl, or C1-C4 haloalkyl,
R4 is C1-C4 alkyl,
R6 is H or a protecting group or a salt thereof, and
R7 is H, Cl or trialkylsilyl;
comprising the steps of:
a) reacting a compound of formula VII with elemental sulfur in the presence of base and a catalyst to give a compound of formula VIB,, , wherein R3, R4, and R7 are as defined above, L1 is a leaving group, and n is 2-8;
b) reacting the compound of formula VIB with a compound of formula VIII, to give a compound of formula V;, , wherein R6 is as defined above and L2 is a leaving group, and
c) converting the compound of formula V to the compound of formula II.