Patent ID: 11892444
Assignee: ROCHE SEQUENCING SOLUTIONS, INC.
Field: Measurement (Instruments)
Classification: CPC G  C  B | IPC B  C  G

Claim 0:
1. A system comprising:
a plurality of sequencing cells, each sequencing cell comprising a nanopore;
a signal generator that applies a signal across the nanopores of the plurality of sequencing cells; and
electrical circuitry coupled with the signal generator and the plurality of sequencing cells, the electrical circuitry configured to:
apply a first voltage across the nanopore of each sequencing cell while the nanopore is in an unthreaded state and measure an open channel voltage for each sequencing cell;
after a molecule is inserted into nanopore of each sequencing cell so that the nanopore is in a threaded state, apply a second voltage across the nanopore of each sequencing cell while the nanopore is in the threaded state and measure a first voltage signal for each sequencing cell;
normalize the first voltage signal for each sequencing cell with the corresponding open channel voltage for each sequencing cell; and
determine an identity of at least a portion of the molecule based on the normalized first voltage signal.