Patent ID: 11945798
Assignee: JANSSEN BIOTECH, INC.
Field: Organic fine chemistry (Chemistry)
Classification: CPC A  C | IPC C

Claim 0:
1. A compound of formula (I) or a pharmaceutically acceptable salt thereof,, wherein
R1 is selected from the group consisting of
C1-6 alkyl optionally substituted by one or more substituents selected from the group consisting of OH, halogen, C3-6 cycloalkyl, —NHC1-6 alkyl, and N(C1-6 alkyl)2;
C1-3 alkoxy;
—C(O)—C1-6 alkyl, optionally substituted by one or more substituents selected from the group consisting of halogen, —NHC1-6 alkyl, —N(C1-6 alkyl)2, and 4-7 membered heterocyclyl;
—C(O)—C3-6 cycloalkyl, optionally substituted by one or more substituents selected from the group consisting of OH and halogen;
—C(O)—C6-10 aryl optionally substituted by one or more halogens;
—C(O)-5-6 membered heteroaryl optionally substituted by one or more halogens;
—N(C1-6 alkyl)2;
—NHC(O)C1-6 alkyl;
—NHC(O)C3-6 cycloalkyl, optionally substituted by one or more substituents selected from the group consisting of OH and halogen;
—C(O)NHC1-6 alkyl optionally substituted by one or more substituents selected from the group consisting of OH and halogen;
—C(O)NHC3-6 cycloalkyl optionally substituted by one or more substituents selected from the group consisting of OH, halogen and —N(C1-6 alkyl)2;
—C(O)-3-7 membered heterocyclyl optionally substituted by one or more substituents selected from the group consisting of OH, halogen, C1-6 alkyl, and C1-6 hydroxyalkyl; and
4-7 membered heterocyclyl optionally substituted by one or more substituents selected from the group consisting of OH and halogen,
R2 is selected from the group consisting of —XC1-6 alkyl optionally substituted by one or more substituents selected from the group consisting of OH, halogen, and —N(C1-6 alkyl)2; and —X(CH2)n-A-(R2A)o,
X is —NH—, —O—, bond or —C≡C—,
n is an integer of 0 to 2,
is an integer of 0 to 3,
A is selected from the group consisting of C3-8 cycloalkyl; C6-10 aryl; 4-11 membered heterocyclyl; and 5-6 membered heteroaryl,
R2A is independently selected from the group consisting of
H;
halogen;
OH;
NH2;
C1-6 alkyl optionally substituted by one or more substituents selected from the group consisting of OH, NH2, halogen, C3-6 cycloalkyl, C1-3 alkoxy, —NHC1-6 alkyl, —NHC1-6 hydroxyalkyl, —NHC1-6 haloalkyl, —NHC3-6 cycloalkyl, —N(C1-6 alkyl)2, —N(C1-6 haloalkyl)2, —NHC(O)C1-6 alkyl, —C(O)NHC1-6 alkyl, —C(O)N(C1-6 alkyl)2, 3-7 membered heterocyclyl and 5-6 membered heteroaryl;
C3-6 cycloalkyl;
C1-3 alkoxy optionally substituted by one or more halogens;
—C(O)NHC1-6 alkyl optionally substituted by one or more substituents selected from the group consisting of OH and halogen;
—C(O)N(C1-6 alkyl)2 optionally substituted by one or more substituents selected from the group consisting of OH and halogen;
—NHC1-6 alkyl optionally substituted by one or more substituents selected from the group consisting of OH, halogen, —NHC1-6 alkyl, —N(C1-6 alkyl)2, and 3-7 membered heterocyclyl optionally substituted by halogen or —N(C1-6 alkyl)2;
—N(C1-6 alkyl)2 where C1-6 alkyl is optionally substituted by one or more halogens;
—NH-4-7 membered heterocyclyl optionally substituted by C1-6 alkyl; and
4-7 membered heterocyclyl,
R3 is selected from the group consisting of
H;
C1-6 alkyl optionally substituted by one or more substituents selected from the group consisting of halogen and C3-6 cycloalkyl;
C3-6 cycloalkyl;
4-7 membered heterocyclyl;
—S(O)2C1-6 alkyl optionally substituted by one or more halogens; and
—S(O)2C3-6 cycloalkyl optionally substituted by one or more halogens, and
R4 is selected from the group consisting of H, halogen and C1-6 alkyl.