Patent ID: 11896674
Assignee: SUZHOU RIBO LIFE SCIENCE CO., LTD.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 18:
19. The siRNA conjugate according to claim 1, wherein the nucleotide at 5′-terminal in the antisense strand is a 5′-phosphate nucleotide or a 5′-phosphate analogue modified nucleotide, wherein 5′-phosphate nucleotide or 5′-phosphate analogue modified nucleotide has a structure as shown by one of Formula (202), (203), (204), (205) or (206):, Formula (203) Formula (204) Formula (205) Formula (206) wherein R represents a group selected from the group consisting of H, OH, F and methoxy, and “Base” represents a base selected from A, U, C, G, and T.