Patent ID: 11933786
Assignee: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS
Field: Measurement (Instruments)
Classification: CPC G  C | IPC C  G

Claim 0:
1. A nucleic acid molecule comprising a nucleotide sequence encoding a VH domain and a VL domain of an antibody which selectively binds to glycosylated PD-L1 relative to unglycosylated PD-L1 and inhibits binding of glycosylated PD-L1 to PD-1,
wherein said antibody has a VH domain comprising CDRs H1, H2 and H3 having the amino acid sequences of SEQ ID NO: 4, SEQ ID NO: 6, and SEQ ID NO: 8, respectively, or having the amino acid sequences of SEQ ID NO: 5, SEQ ID NO: 7, and SEQ ID NO: 9, respectively; and wherein said antibody has a VL domain comprising CDRs L1, L2 and L3 having the amino acid sequences of SEQ ID NO: 12, SEQ ID NO: 14, and SEQ ID NO: 16, respectively; or
wherein said antibody has a VH domain comprising CDRs H1, H2 and H3 having the amino acid sequences of SEQ ID NO: 20, SEQ ID NO: 22, and SEQ ID NO: 24, respectively, or SEQ ID NO: 21, SEQ ID NO: 23, and SEQ ID NO: 25, respectively; and wherein said antibody has a VL domain comprising CDRs L1, L2 and L3 having the amino acid sequences of SEQ ID NO: 28, SEQ ID NO: 30, and SEQ ID NO: 32, respectively.