Patent ID: 11857809
Assignee: SALK INSTITUTE FOR BIOLOGICAL STUDIES
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C  G | IPC A  C  G

Claim 6:
7. A method of treating or ameliorating a neurological disease or disorder in a subject, the method comprising:
(a) delivering an effective amount of an exogenous polynucleotide encoding an ultrasound-responsive, non-mammalian TRP-N or TRP-4 protein which is expressed in neurons of a targeted neuroanatomy site of the subject to functionally modulate the nervous system by sonogenetic intervention; and
(b) sonogenetically altering the activity or function of the expressed non-mammalian TRP-N or TRP-4 protein in the neurons by applying ultrasound to the targeted neuroanatomy site, thereby treating or ameliorating the neurological disease or disorder in the subject.