Patent ID: 11912760
Assignee: PHAROSGEN CO., LTD
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A  G | IPC A  C  G

Claim 3:
4. The doppel-targeting molecule of claim 1, wherein:
(a) the heavy chain variable regions comprises the amino acid sequence of SEQ ID NO: 134 and the light chain variable region comprises the amino acid sequence of SEQ ID NO: 115;
(h) the heavy chain variable regions comprises the amino acid sequence of SEQ ID NO: 141 and the light chain variable region comprises the amino acid sequence of SEQ ID NO: 122;
(p) the heavy chain variable regions comprises the amino acid sequence of SEQ ID NO: 149 and the light chain variable region comprises the amino acid sequence of SEQ ID NO: 130;
(q) the heavy chain variable regions comprises the amino acid sequence of SEQ ID NO: 150 and the light chain variable region comprises the amino acid sequence of SEQ ID NO: 131;
(r) the heavy chain variable regions comprises the amino acid sequence of SEQ ID NO: 151 and the light chain variable region comprises the amino acid sequence of SEQ ID NO: 132; or
(s) the heavy chain variable regions comprises the amino acid sequence of SEQ ID NO: 152 and the light chain variable region comprises the amino acid sequence of SEQ ID NO: 133; and
wherein the doppel-targeting molecule interferes with interaction of doppel and VEGFR2.