Patent ID: 11939581
Assignee: ALIGOS THERAPEUTICS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A small interfering RNA (siRNA) that targets human CD274 mRNA, comprising a sense strand and an antisense strand, wherein the antisense strand comprises nucleotides selected from the group consisting of unmodified nucleotides and modified nucleosides,
wherein each modified nucleoside contains a modified sugar, contains a modified nucleobase or is abasic, or both contains a modified sugar and contains a modified nucleobase or is abasic;
wherein each linkage between the nucleosides is a phosphorothioate, phosphodiester, phosphoramidate, thiophosphoramidate, methylphosphate, methylphosphonate, phosphonoacetate, amide, boranophosphate, or any combination thereof;
wherein the siRNA has a sequence as set forth in any one of SEQ ID NO: 303, and is at least 85% complementary to a fragment of human CD274 mRNA; and
wherein the antisense strand comprises a 5′-phosphate mimic.