Patent ID: 11931414
Assignee: SEAGEN INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 4:
5. The Ligand Drug Conjugate compound of claim 1, wherein the NAMPT Tail (TN) Unit is an amino alcohol moiety having the structure of:, wherein
R4 is hydrogen or optionally substituted C1-C4 alkyl; and
the wavy line indicates the site of covalent attachment to IN,, or
wherein the Tail (TN) Unit is a benzamide moiety covalently attached to IN through its amide nitrogen atom, wherein the benzamide moiety has the structure of:, wherein Xb is —H, halogen, —OH, optionally substituted C1-C4 alkoxy, optionally substituted C1-C4 alkyl, or optionally substituted —NH2;
R4 is hydrogen or optionally substituted C1-C4 alkyl; and
the wavy line indicates the site of covalent attachment to IN; and
wherein the benzamide moiety is optionally cyclized to IN wherein the amide nitrogen atom of the benzamide moiety is the site of said cyclization so that R4 is replaced by a covalent bond,
or
wherein the benzamide moiety has the structure of:, , or
wherein the NAMPT Tail (TN) Unit is a (hetero)aryl or biaryl moiety having the structure of:, wherein Xb is —H, halogen, —OH, optionally substituted C1-C4 alkoxy, optionally substituted C1-C4 alkyl, or optionally substituted —NH2; and
the wavy line indicates the site of covalent attachment to IN.