Patent ID: 11908672
Assignee: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
Field: Electrical machinery, apparatus, energy (Electrical engineering)
Classification: CPC H | IPC H

Claim 13:
14. A method for reducing the charge of precursor ions of the same compound that have different mass-to-charge ratio (m/z) values in order to continuously accumulate and transmit the precursor ions at a single m/z value, comprising:
instructing an ion source device to ionize a compound of a sample using a processor, producing two or more precursor ions of the compound with different m/z values;
instructing a reagent source device to supply charge reducing reagent using the processor;
instructing an ion guide device positioned between a mass filter device and both the ion source device and the reagent source device to receive the two or more precursor ions from the ion source device and the charge reducing reagent from the reagent source device using the processor;
instructing the ion guide device to apply an alternating current (AC) voltage and a direct current (DC) voltage to one or more electrodes of the ion guide device that creates a pseudopotential to trap the received two or more precursor ions with m/z values below a threshold m/z in the ion guide device and to, in turn, cause the trapped two or more precursor ions to be charge reduced by the received charge reducing reagent so that m/z values of the two or more precursor ions increase to a single m/z value above the threshold m/z using the processor; and
instructing the ion guide device to apply the DC voltage to the one or more electrodes relative to a DC voltage applied to electrodes of the mass filter device that causes the two or more precursor ions with m/z values increased to the single m/z value to be continuously transmitted to the mass filter device using the processor.