Patent ID: 11857603
Assignee: ASCENDIS PHARMA BONE DISEASES A/S
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 0:
1. A method of treating a human patient having hypoparathyroidism comprising subcutaneously administering to the subject a PTH compound, wherein the pharmacokinetic profile of the PTH compound exhibits a peak to trough ratio of less than 4 within one administration interval at a steady state,
wherein the PTH compound is a water-soluble controlled-release PTH compound of formula (Ia) or a pharmaceutically acceptable salt thereof:, wherein
-D is a PTH moiety, which has the sequence of SEQ ID NO: 51;
-L2-L1- has the formula:, wherein the unmarked dashed line indicates the attachment to a nitrogen of -D by an amide bond; and the dashed line marked with an asterisk indicates attachment to —Z;
x is 1;
—Z comprises a moiety of formula (b):, wherein the dashed line indicates attachment to -L2 and m and p are independently of each other an integer ranging from 150-1000; and
the PTH moiety is released with a release half-life of at least 12 hours.