Patent ID: 11885802
Assignee: AMBERGEN, INC.
Field: Measurement (Instruments)
Classification: CPC G | IPC G

Claim 0:
1. A manufacture comprising:
(a) at least a first target autoantigen selected from the group consisting of a target antigen of ketch-like 12 comprising the amino acid sequence of SEQ ID NO:12 and a homolog thereof and/or at least a second target autoantigen selected from the group consisting of a target autoantigen of hexokinase 1 comprising the amino acid sequence of SEQ ID NO:1 and a homolog thereof, wherein each of the at least first and/or second target autoantigen is immobilized on a solid support,
(b) a labeled anti-immunoglobulin antibody; and
(c) a positive control for primary biliary cirrhosis (PBC), wherein the positive control comprises an autoantibody with known titer for at least first and/or second target autoantigen of (a) wherein the positive control autoantibody is capable of binding the immobilized at least first and/or second target autoantigen (a),
wherein the kelch-like 12 homolog comprise the amino acid sequence selected from the group consisting of SEQ ID NOs:13,14,15,16,17 and 18, and wherein the hexokinase 1 homolog comprise the amino acid sequence selected from the group consisting of SEQ ID NOs:7, 8, 9, 10 and 11.