Patent ID: 11857520
Assignee: NORTIC HOLDINGS INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 0:
1. A method of treating pain associated with a condition selected from the group consisting of tri-geminal neuralgia, facial neuropathic pain, facial cancer induced neuropathic pain, migraine pain, and cluster headache pain, comprising
incorporating a preservative-free nasal spray formulation into a mechanical multi-dose nasal spray pump device, the nasal spray formulation consisting of from about 5% to about 30% w/v of a locally active sodium channel blocker or a pharmaceutically acceptable salt thereof, from about 0.25% to about 5% w/v of a buffering agent, an optional second active agent selected from the group consisting of epinephrine, ketamine, a vasodilator, an anticonvulsant drug, a muscle relaxant, and combinations of any of the foregoing, and from about 5 to about 99% w/v of a pharmaceutically acceptable carrier for nasal administration, the nasal spray formulation having a viscosity from about 0.8 to about 1.1 cps, the mechanical multi-dose nasal spray pump device spraying a unit dose of the nasal spray formulation in a wide plume to provide a mean spray angle from about 50 to about 95 degrees and small droplet size having a mean Dv 10 from about 10 to about 30 μm, a mean Dv50 from about 20 to about 60 μm, and a mean Dv90 from about 80 to about 120 μm when actuated, the unit dose when sprayed into the nasal cavity of a human patient being therapeutically effective to treat a condition selected from the group consisting of tri-geminal neuralgia, facial neuropathic pain, facial cancer induced neuropathic pain, migraine pain, and cluster headache pain.