Patent ID: 11865181
Assignee: YALE UNIVERSITY
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 0:
1. A modified peptidic oligomer comprising at least 5 cationic residues, wherein the at least 5 cationic residues are residues at positions i, i+3, i+4, i+7, and i+8 with respect to the first cationic residue, wherein the peptidic oligomer further comprises at least two unnatural amino acid residues selected from the group consisting of (R)-2-(7′-octenyl)alanine (R8), (S)-2-(4′-pentenyl)alanine (S5), (R)-2-(4′-pentenyl)alanine (R5), and (S)-2-(7′-octenyl)alanine and a hydrocarbon staple formed between the two unnatural amino acid residues, and wherein the amino acid sequence of the peptidic oligomer is selected from the group consisting of SEQ ID NO:5 and SEQ ID NO:11.