Patent ID: 11884721
Assignee: ÉCOLE POLYTECHNIQUE FÉDÉRALE DE LAUSANNE
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A  B | IPC A  B  C

Claim 7:
8. A method for inducing antigen-specific tolerance to an antigen in a subject, the method comprising:
administering a composition to a subject in an amount effective to induce antigen-specific tolerance, the composition comprising an antigen recombinantly fused or chemically conjugated with an erythrocyte-binding moiety,
wherein the erythrocyte-binding moiety comprises an antibody fragment or a peptide ligand that specifically binds to human erythrocytes;
wherein the antigen is an antigen to which a subject develops an unwanted immune response, wherein the antigen is associated with multiple sclerosis; and
wherein the composition reduces the number of resident lymph node and spleen cells expressing interferon-gamma (IFNγ), as compared to the number of resident lymph node and spleen cells expressing IFNγ when the human is exposed to the antigen.