Patent ID: 11945788
Assignee: NURAY CHEMICALS PRIVATE LIMITED
Field: Organic fine chemistry (Chemistry)
Classification: CPC C | IPC C

Claim 11:
12. A process for preparing pitolisant or a pharmaceutically acceptable salt thereof, comprising:
a) reacting 3-(piperidin-1-yl)propan-1-ol, with Formula-(III);, in the presence of a solvent and a base to obtain pitolisant, wherein the AG is an activating group;
b) optionally treating pitolisant with an acid to form pitolisant first salt; and
c) converting pitolisant or pitolisant first salt to a pharmaceutically acceptable salt or solid state forms of pitolisant;

wherein the base in step a) is not sodium hydride; and
wherein AG is selected from a methyl sulfonate, an ethylsulfonate, a phenylsulfonate, a tolylsulfonate, a p-nitrophenyl sulfonate, a benzyl sulfonate, a trifluoromethylacyl ester, a trichloromethylacyl ester, a phenylacyl ester, a p-nitro-phenylacyl ester, and a p-chloro-phenylacyl ester.