Patent ID: 11951131
Assignee: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A nucleic acid comprising:
(a) a suicide gene; and
(b) a nucleotide sequence encoding a chimeric antigen receptor (CAR), wherein the CAR comprises a single chain comprising an antigen recognition domain, a transmembrane (TM) domain, and a T cell activation domain, wherein the CAR has antigenic specificity for signaling lymphocyte activating molecule F7 (SLAMF7), wherein the TM domain comprises a TM domain of CD8α or CD28, wherein the antigen recognition domain comprises the amino acid sequences of SEQ ID NOs: 1-6;
wherein the nucleotide sequence encoding the CAR is positioned 3′ of the suicide gene, and wherein the suicide gene is an inducible caspase 9 (IC9) gene.