Patent ID: 11919839
Assignee: VALO HEALTH, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A  Y | IPC A  C

Claim 0:
1. A method of treating, inhibiting, or eliminating a disease or disorder associated with inhibition of HDAC8, the method comprising administering to a patient in need thereof a therapeutically effective amount of a compound of formula (I):, or a pharmaceutically acceptable salt thereof,
wherein:
X1, X2, X3, and X4 are each CH;
Ra is hydrogen;
Rb is —C(O)Rc;
or alternatively, Ra and Rb are combined to form a heterocycle, wherein said heterocycle is optionally substituted with one or more Rd;
Rc is aryl, optionally substituted with one or more Rd or Re;
Rd is hydrogen, C1-C6 alkyl, oxo, C3-C8 cycloalkyl, or —ORe,
or two Rd when attached to the same carbon atom can form a C3-C12 spirocycle or a 3- to 12-membered spiroheterocycle;
Re is aryl; and
A is hydrogen;, with the proviso that:
when Ra is H and Rb is —C(O)Rc, then Rc cannot be phenyl, 1-naphthyl, 2-naphthyl, or 4-biphenyl.