Patent ID: 11884647
Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Field: Organic fine chemistry (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 27:
28. A compound selected from the group consisting of:, 1

3-((4-ethylphenyl)sulfonyl)-4-(4- methylpiperazin-1-yl)- 6-(trifluoromethoxy)quinoline

 

2

3-((4-ethylphenyl)sulfonyl)-4-(piperidin- 1-yl)-6-(trifluoromethoxy)quinoline

 

3

4-(3-((4-ethylphenyl)sulfonyl)-6- (trifluoromethoxy)quinolin-4- yl)morpholine

 

4

3-((4-ethylphenyl)sulfonyl)-4-(4- methylpiperidin-1-yl)-6- (trifluoromethoxy)quinoline

 

5

2-(4-(3-((4-ethylphenyl)sulfonyl)-6- (trifluoromethoxy)quinolin-4- yl)piperazin-1-yl)ethan-1-ol

 

6

3-((4-ethylphenyl)sulfonyl)-4-(4- ethylpiperazin-1-yl)-6- (trifluoromethoxy)quinoline

 

7

3-((4-ethylphenyl)sulfonyl)-4-(4-methyl- 1,4-diazepan-1-yl)-6- (trifluoromethoxy)quinoline

 

8

1-(3-((4-ethylphenyl)sulfonyl)-6- (trifluoromethoxy)quinolin-4- yl)piperidin-4-ol

 

9

ethyl 4-(3-((4-ethylphenyl)sulfonyl-6- (trifluoromethoxy)quinolin-4- yl)piperazine-1-carboxylate

 

10

3-((4-ethylphenyl)sulfonyl)-4-(4-(4- fluorophenyl)piperazin-1-yl)-6- (trifluoromethoxy)quinoline

 

11

4-([1,4′-bipiperidin]-1′-yl)-3-((4- ethylphenyl)sulfonyl)-6- (trifluoromethoxy)quinoline

 

12

1-(3-((4-ethylphenyl)sulfonyl)-6- (trifluoromethoxy)quinolin-4-yl)-4- phenylpiperidin-4-ol

 

13

3-((4-ethylphenyl)sulfonyl)-4-(4- phenylpiperazin-1-yl)-6- (trifluoromethoxy)quinoline

 

14

3-((4-ethylphenyl)sulfonyl)-4-(pyrrolidin- 1-yl)-6-(trifluoromethoxy)quinoline

 

15

1-(3-((4-ethylphenyl)sulfonyl)-6- methoxyquinolin-4-yl)piperidin-4-ol

 

16

ethyl 4-(3-((4-ethylphenyl)sulfonyl)-6- methoxyquinolin-4-yl)piperazine-1- carboxylate

 

17

3-((4-ethylphenyl)sulfonyl)-4-(4-(4- fluorophenyl)piperazin-1- yl)-6-methoxyquinoline

 

18

N-cyclohexyl-3-((4- ethylphenyl)sulfonyl)-6- methoxyquinolin-4-amine

 

19

3-((4-ethylphenyl)sulfonyl)-N-(4- fluorophenyl)-6-methoxyquinolin- 4-amine

 

20

3-((4-ethylphenyl)sulfonyl)-6-methoxy-4- (4-methylpiperazin-1-yl)quinoline

 

21

3-((4-ethylphenyl)sulfonyl)-6-methoxy-4- (piperidin-1-yl)quinoline

 

22

4-(3-((4-ethylphenyl)sulfonyl)-6- methoxyquinolin-4-yl)morpholine

 

23

3-((4-ethylphenyl)sulfonyl-6-methoxy-4- (4-methylpiperidin-1-yl)quinoline

 

24

3-((4-ethylphenyl)sulfonyl)-4-(4- ethylpiperazin-1-yl)-6-methoxyquinoline

 

25

3-((4-ethylphenyl)sulfonyl)-6-methoxy-4- (pyrrolidin-1-yl)quinoline

 

26

3-((4-ethylphenyl)sulfonyl)-6-methoxy-4- (4-phenylpiperazin-1-yl)quinoline

 

27

4-([1,4′-bipiperidin]-1′-yl)-3-((4- ethylphenyl)sulfonyl)-6- methoxyquinoline

 

28

1-(3-((4-ethylphenyl)sulfonyl)-6- methoxyquinolin-4- yl-4-phenylpiperidin-4-ol

 

29

3-((4-ethylphenyl)sulfonyl)-6-methoxy-4- (4-methyl-1,4-diazepan-1-yl)quinoline

 

30

3-((4-ethylphenyl)sulfonyl-4-(4- isopropylpiperazin-1-yl)-6- methoxyquinoline

 

31

4-(azepan-1-yl)-3-((4- ethylphenyl)sulfonyl)-6- methoxyquinoline

 

32

3-((4-ethylphenyl)sulfonyl)-6-methyl-4- (4-methylpiperazin-1-yl)quinoline

 

33

3-((4-ethylphenyl)sulfonyl)-6-methyl-4- (4-methyl-1,4-diazepan-1-yl)quinoline

 

34

1-(3-((4-ethylphenyl)sulfonyl)-6- methylquinolin-4-yl)piperidin-4-ol

 

35

4-([1,4′-bipiperidin]-1′-yl)-3-((4- ethylphenyl)sulfonyl)-6-methyl)quinoline

 

36

3-((4-ethylphenyl)sulfonyl)-6-methyl-4- (piperidin-1-yl)quinoline

 

37

3-((4-ethylphenyl)sulfonyl)-6-fluoro-4- (4-methylpiperazin-1-yl)quinoline

 

38

3-((4-ethylphenyl)sulfonyl)-6-fluoro-4- (4-methyl-1,4-diazepan-1-yl)quinoline

 

39

1-(3-((4-ethylphenyl)sulfonyl)-6- fluoroquinolin-4-yl)piperidin-4-ol

 

40

4-([1,4′-bipiperidin]-1′-yl)-3-((4- ethylphenyl)sulfonyl)-6-fluoroquinoline

 

41

3-((4-ethylphenyl)sulfonyl-6-fluoro-4- (piperidin-1-yl)quinoline

 

42

2-(4-(3-((4-ethylphenyl)sulfonyl-6- (trifluoromethoxy)quinolin-4-yl)-1,4- diazepan-1-yl)acetic acid

 

43

4-([1,4′-bipiperidin]-1yl)-3-((4- methoxyphenyl)sulfonyl)-6- (trifluoromethoxy)quinoline

 

44

1-(3-((4-methoxyphenyl)sulfonyl)-6- (trifluoromethoxy)quinolin-4- yl)piperidin-4-ol

 

45

4-(4-(3-((4-ethylphenyl)sulfonyl)-6- (trifluoromethoxy)quinolin-4- yl)piperazin-1-yl)benzonitrile

 

46

3-((4-ethylphenyl)sulfonyl)-4-(4- (pyrrolidin-1-yl)piperidin-1-yl)-6- (trifluoromethoxy)quinoline

 

47

ethyl)-(3-((4-ethylphenyl)sulfonyl)-6- (trifluoromethoxy)quinolin-4- yl)piperidine-4-carboxylate

 

48

(1-(3-((4-ethylphenyl)sulfonyl)-6- (trifluoromethoxy)quinolin-4- yl)piperidin-4-yl)methanol

 

49

N-benzyl-3-((4-ethylphenyl)sulfonyl)-N- methyl-6-(trifluoromethoxy)quinolin-4- amine

 

50

3-((4-ethylphenyl)sulfonyl)-N-(4- methylpiperazin-1-yl)-6- (trifluoromethoxy)quinolin-4-amine

 

51

3-((4-ethylphenyl)sulfonyl-4-(1H-1,2,4- triazol-1-yl)-6- (trifluoromethoxy)quinoline

 

52

8-(3-((4-ethylphenyl)sulfonyl)-6- (trifluoromethoxy)quinolin-4- yl)-1,4-dioxa-8-azaspiro[4,5]decane

 

53

1-(3-((4-ethylphenyl)sulfonyl)-6- (trifluoromethoxy)quinolin-4- yl)piperidine-4-carboxylate acid

 

54

4-((4-([1,4′-bipiperidin]-1′-yl)-6- (trifluoromethoxy)quinolin-3- yl)sulfonyl)benzonitrile

 

55

2-(4-([1,4′-bipiperidin]-1′-yl-3-((4- ethylphenyl)sulfonyl)quinolin-6- yl)acetonitrile

 

56

4-([1,4′-bipiperidin]-1′-yl)-3-((3,4- dimethoxyphenyl)sulfonyl)-6- (trifluoromethoxy)quinoline

 

57

3-((3,4-dimethoxyphenyl)sulfonyl)-4-(4- methyl-1,4-diazepan-1-yl)-6- (trifluoromethoxy)quinoline

 

58

1-(3-((3,4-dimethoxyphenyl)sulfonyl)-6- (trifluoromethoxy)quinolin-4- yl)piperidin-4-ol

 

59

4-([1,4,-bipiperidin]-1′-yl-3-((4- nitrophenyl)sulfonyl-6- (trifluoromethoxy)quinoline

 

60

4-(4-methyl-1,4-diaxepan-1-yl)-3-((4- nitrophenyl)sulfonyl-6- (trifluoromethoxy)quinoline

 

61

1-(3-((4-nitrophenyl)sulfonyl)-6- (trifluoromethoxy)quinolin-4- yl)piperidin-4-ol

 

62

ethyl 3-((4-ethylphenyl)sulfonyl)-4-(4- hydroxypiperidin-1-yl)quinoline-6- carboxylate

 

63

ethyl 3-((4-ethylphenyl)sulfonyl)-4-(4- methyl-1,4-diazepan-1-yl)quinoline-6- carboxylate

 

64

ethyl 4-([1,4′-bipiperidin]-1′-yl)-3-((4- ethylphenyl)sulfonyl)quinoline-6- carboxylate

 

65

3-((4-ethylphenyl)sulfonyl)-4-(4- hydroxypiperidin-1-yl)quinoline-6- carboxylate acid

 

66

3-((4-ethylphenyl)sulfonyl)-4-(4-methyl- 1,4-diazepan-1-yl)quinoline-6-carboxylate acid

 

67

4-([1,4′-bipiperidin]-1′-yl)-3-((4- ethylphenyl)sulfonyl)quinoline-6- carboxylate acid

 

68

3-((3,4-dimethoxyphenyl)sulfonyl)-N,N- diethyl)l-6-trifluoromethoxy)quinolin-4- amine

 

69

2-((3-((3,4-dimethoxyphenyl)sulfonyl)-6- (trifluoromethoxy)quinolin-4- yl)amino)ethan-1-ol

 

70

1-(3-((3,4-dimethoxyphenyl)sulfonyl)-6- (trifluoromethoxy)quinolin-4- yl)piperidin-3-ol

 

71

3-((3,4-dimethoxyphenyl)sulfonyl)-N,N- dipropyl-6-(trifluoromethoxy)quinolin-4- amine

 

72

2,2′-((3-((3,4-dimethoxyphenyl)sulfonyl)-6- (trifluoromethoxy)quinolin-4- yl)azanediyl)bis(ethan-1-ol)

 

73

2-((3-((3,4-dimethoxyphenyl)sulfonyl)-6- (trifluoromethoxy)quinolin-4- yl)amino)ethan-1-ol

 

74

N,N-dibutyl-3-((3,4- dimethoxyphenyl)sulfonyl)-6- (trifluoromethoxy)quinolin-4-amine

 

75

1-(3-((4-ethylphenyl)sulfonyl)-6- nitroquinolin-4-yl)piperidin-4-ol

 

76

3-((4-ethylphenyl)sulfonyl-4-(4-methyl- 1,4-diazepan-1-yl)-6-nitroquinoline

 

77

4-([1,4′-bipiperidin]-1′-yl)-3-((4- ethylphenyl)sulfonyl)-6-nitroquinoline

 

78

N,N-diethyl)l-3-((4-ethylphenyl)sulfonyl)- 6-nitroquinolin-4-amine

 

79

3-((4-ethylphenyl)sulfonyl)-6-methoxy-4- (1H-1,2,4-triazol-1-yl)quinoline

 

80

ethyl 3-((4-ethylphenyl)sulfonyl)-4-(1H- 1,2,4-triazol-1-yl)quinoline-6-carboxylate

 

81

N,N-diethyl)l-3-((4-ethylphenyl)sulfonyl)- 6-(trifluoromethoxy)quinolin-4-amine

 

82

1-(3-((4-ethylphenyl)sulfonyl)-6- (trifluoromethoxy)quinolin-4- yl)piperidin-3-ol

 

83

3-((4-ethylphenyl)sulfonyl)-6-methoxy- N-(4-methylpiperazin-1-yl)quinolin-4- amine

 

84

ethyl 3-((4-ethylphenyl)sulfonyl)-4-((4- methylpiperazin-1-yl)amino)quinoline-6- carboxylate

 

85

3-((4-methoxyphenyl)sulfonyl)-N-(4- methylpiperazin-1-yl)-6- (trifluoromethoxy)quinolin-4-amine

 

86

3-((4-methoxyphenyl)sulfonyl)-4-(1H- 1,2,4-triazol-1-yl)-6- (trifluoromethoxy)quinoline

 

87

N,N-dibutyl-3-((4-ethylphenyl)sulfonyl)- 6-(trifluoromethoxy)quinolin-4-amine

 

88

3-((3,4-dimethoxyphenyl)sulfonyl)-N-(4- methylpiperazin-1-yl)-6- (trifluoromethoxy)quinolin-4-amine

 

89

3-((3,4-dimethoxyphenyl)sulfonyl)-4- (1H-1,2,4-triazol-1-yl)-6- (trifluoromethoxy)quinoline

 

90

N-(4-methylpiperazin-1-yl)-6- (trifluoromethoxy)-3-((4- (trifluoromethoxy)phenyl)sulfonyl)quinolin- 4-amine

 

91

4-(1H-1,2,4-triazol-1-yl)-6- (trifluoromethoxy)-3-((4- (trifluoromethoxy)phenyl)sulfonyl)quinoline

 

92

3-((4-butoxyphenyl)sulfonyl)-N-(4- methylpiperazin-1-yl)-6- (trifluoromethoxy)quinolin-4-amine

 

93

3-((4-butoxyphenyl)sulfonyl)-4-(1H- 1,2,4-triazol-1-yl)-6- (trifluoromethoxy)quinoline

 

94

3-((4-methoxyphenyl)sulfonyl)-N-(4- methylpiperazin-1-yl)-6-nitroquinolin-4- amine

 

95

2-((3-((4-ethylphenyl)sulfonyl)-6- (trifluoromethoxy)quinolin-4- yl)amino)ethan-1-ol

 

96

3-((3,4-dimethoxyphenyl)sulfonyl)-6,7- dimethoxy-4-(1H-1,2,4-triazol-1- yl)quinoline

 

97

3-((4-methoxyphenyl)sulfonyl)-6-nitro-4- (1H-1,2,4-triazol-1-yl)quinoline

 

98

2-(3-((4-methoxyphenyl)sulfonyl)-4-(1H- 1,2,4-triazol-1-yl)quinolin-6- yl)acetonitrile

 

99

2-(3-((4-methoxyphenyl)sulfonyl)-4-((4- methylpiperazin-1-yl)amino)quinolin-6- yl)acetonitrile

 

100

N,N-diethyl)l-2-(4-(3-((4- ethylphenyl)sulfonyl)-6- (trifluoromethoxy)quinolin-4-yl)-1,4- diazepan-1-yl)ethan-1-amine

 

101

N,N-diethyl)l-2-((1-(3-((4- ethylphenyl)sulfonyl)-6- (trifluoromethoxy)quinolin-4- yl)piperidin-4-yl)oxy)ethan-1-amine

 

102

1′-(3-((4-ethylphenyl)sulfonyl)-6- (trifluoromethoxy)quinolin-4-yl-[1,4′- bipiperidin]-4-ol

 

103

N,N-diethyl)l-1-(3-((4- ethylphenyl)sulfonyl-6- (trifluoromethoxy)quinolin-4- yl)piperidin-4-amine

 

104

5-((3-((4-ethylphenyl)sulfonyl)-6- (trifluoromethoxy)quinolin-4- yl)amino)pentan-1-ol

 

105

3-((4-ethylphenyl)sulfonyl)-N-(piperidin- 1-yl)-6-(trifluoromethoxy)quinolin-4- amine

 

106

3-((4-ethylphenyl)sulfonyl)-N-(pyridin-4- ylmethyl)-6-(trifluoromethoxy)quinolin- 4-amine

 

107

3-((4-ethylphenyl)sulfonyl)-N-(pyridin-4- yl)-6-(trifluoromethoxy)quinolin-4-amine

 

108

3-((4-ethylphenyl)sulfonyl)-4-(1H-pyrrole- 1-yl)-6-(trifluoromethoxy)quinoline

 

109

3-((4-ethylphenyl)sulfonyl)-4-(1H- pylazol-1-yl)-6- (trifluoromethoxy)quinoline

 

110

3-((4-ethylphenyl)sulfonyl)-4-(1H-1,2,3- triazol-1-yl)-6- (trifluoromethoxy)quinoline

 

111

4-((3-((4-ethylphenyl)sulfonyl)-6- (trifluoromethoxy) quinolin-4-yl)amino)butan-1-ol

 

112

4-(1H-benzo[d][1,2,3]triazol-1-yl)-3-((4- ethylphenyl)sulfonyl)-6- (trifluoromethoxy)quinoline

 

113

1′-(3-((4-methoxyphenyl)sulfonyl)-6- (trifluoromethoxy)quinolin-4-yl-[1,4′- bipiperidin]-4-ol

 

114

4-([1,4′-bipiperidin]-1′-yl)-3-((4- methoxyphenyl)sulfonyl)-6- nitroquinoline

 

115

2-(4-([1,4′-bipiperidin]-1yl)-3-((4- methoxyphenyl)sulfonyl)quinolin-6- yl)acetonitrile

 

116

4-([1,4′-bipiperidin]-1′-yl)-6-butoxy-3- ((3,4-dimethoxyphenyl) sulfonyl)quinoline

 

117

3-((4-ethylphenyl)sulfonyl)-4-(4-methyl- 1H-imidazol-1-yl)-6- (trifluoromethoxy)quinoline

 

118

3-((4-ethylphenyl)sulfonyl)-4-(1H- imidazol-1-yl)-6- (trifluoromethoxy)quinoline

 

119

4-([1,4′-bipiperidin]-1′-yl)-3-((4- butoxyphenyl) sulfonyl)-6-(trifluoromethoxy)quinoline

 

120

4-([1,4′-bipiperidin]-1′-yl)-6- (trifluoromethoxy)-3-((4- (trifluoromethoxy)phenyl)sulfonyl)quinoline

 

121

4-([1,4′-bipiperidin]-1′-yl)-3-((3,4- dimethoxyphenyl)sulfonyl)-6- (methylthio)quinoline

 

122

4-([1,4′-bipiperidin]-1′-yl)-3-((3,4- dimethoxyphenyl)sulfonyl)-6,7- dimethoxyquinoline

 

123

6-butoxy-3-((3,4- dimethoxyphenyl)sulfonyl)-N,N- diethyl)lquinolin-4-amine

 

124

N,N-dibutyl-3-((3,4- dimethoxyphenyl)sulfonyl)-6- (methythio)quinolin-4-amine

 

125

3-((4-ethylphenyl)sulfonyl)-4-(1H- tetrazol-1-yl)-6- (trifluorotmethoxy)quinoline

 

126

N-(3-((4-ethylphenyl)sulfonyl)-6- (trifluoromethoxy)quinolin-4- yl)morpholin-4-amine

 

127

4-(4-ethylphenyl)-1-(3-((4- ethylphenyl)sulfonyl)-6- (trifluoromethoxy)quinolin-4- yl)piperidin-4-ol

 

128

ethyl 4-(4-(4-ethylphenyl)-4- hydroxypiperidin-1-yl)-3-((4- ethylphenyl)sulfonyl)quinoline-6- carboxylate

 

129

4-(4-ethylphenyl)-1-(3-((4- methoxyphenyl)sulfonyl)-6- (trifluoromethoxy)quinolin-4- yl)piperidin-4-ol

 

130

ethyl 3-((4-ethylphenyl)sulfonyl)-4-(4- hydroxy-[1,4′-bipiperidin]-1′- yl)quinoline-6-carboxylate

 

131

ethyl 4-(4-(2-(diethyl)lamino)ethyl)-1,4- diazepan-1-yl)-3-((4- ethylphenyl)sulfonyl)quinoline-6- carboxylate

 

132

ethyl 4-(4-(2- (diethyl)laminotethoxy)piperidin-1-yl)-3- ((4-ethylphenyl)sulfonyl)quinoline-6- carboxylate

 

133

ethyl 4-(1H-benzo[d][1,2,3]triazol-1-yl)-3- ((4-ethylphenyl)sulfonyl)quinoline-6- carboxylate

 

134

ethyl 3-((4-ethylphenyl)sulfonyl)-4-(1H- imidazol-1-yl)quinoline-6-carboxylate

 

135

ethyl 3-((4-ethylphenyl)sulfonyl)-4-(3- hydroxypiperidin-1-yl)quinoline-6- carboxylate

 

136

ethyl 4-([1,4′-bipiperidin]-1′-yl)-3-((4- methoxyphenyl)sulfonyl)quinoline-6- carboxylate

 

137

ethyl 4-(3-hydroxypiperidin-1-yl)-3-((4- methoxyphenyl)sulfonyl)quinoline-6- carboxylate

 

138

ethyl 4-(4-hydroxy-[1,4′-bipiperidin]-1′- yl-3-((4- methoxyphenyl)sulfonyl)quinoline-6- carboxylate

 

139

ethyl 4-(4-(2-(diethyl)lamino)ethyl)-1,4- diazepan-1-yl)-3-((4- methoxyphenyl)sulfonyl)quinoline-6- carboxylate

 

140

ethyl 4-(4-(2- (diethyl)lamino)ethoxy)piperidin-1-yl)-3- ((4-methoxyphenyl)sulfonyl)quinoline-6- carboxylate

 

141

ethyl 4-(1H-imidazol-1-yl)-3-((4- methoxyphenyl)sulfonyl)quinoline-6- carboxylate

 

142

ethyl 4-(1H-benzo[d][1,2,3]triazol-1-yl)- 3-((4-methoxyphenyl)sulfonyl)quinoline- 6-carboxylate

 

143

4-([1,4′-bipiperidin]-1′-yl)-3-((4- methoxyphenyl)sulfonyl-N- methyl)quinoline-6-carboxamide

 

144

ethyl 3-((4-methoxyphenyl)sulfonyl)-4- (4-methyl-1,4-diazepan-1-yl)quinoline-6- carboxylate

 

145

1-(3-((4-ethylphenyl)sulfonyl)-6- (trifluoromethoxy)quinolin-4-yl)-4-(4- methoxyphenyl)piperidin-4-ol

 

146

1-(3-((4-ethylphenyl)sulfonyl)-6- (trifluoromethoxy)quinolin-4-yl)-4-(3- methoxyphenyl)piperidin-4-ol

 

147

4-(benzo[d][1,3]dioxol-5-yl)-1-(3-((4- ethylphenyl)sulfonyl)-6- (trifluoromethoxy)quinolin-4- yl)piperidin-4-ol

 

148

ethyl 3-((4-ethylphenyl)sulfonyl)-4-(4- hydroxy-4-(4-methoxyphenylpiperidin- 1-yl)quinoline-6-carboxylate

 

149

ethyl 3-((4-ethylphenyl)sulfonyl-4-(4- hydroxy-4-(3-methoxyphenyl)piperidin- 1-yl)quinoline-6-carboxylate

 

150

4-(3-methoxyphenyl)-1-(3-((4- methoxyphenyl)sulfonyl)-6- (trifluoromethoxy)quinolin-4- yl)piperidin-4-ol

 

151

3-((4-butoxyphenyl)sulfonyl)-4-(4- methyl-1,4-diazepan-1-yl)-6- (trifluoromethoxy)quinoline

 

152

1′-(3-((4-butoxyphenyl)sulfonyl)-6- (trifluoromethoxy)quinolin-4-yl)-[1,4′- bipiperidin]-4-ol

 

153

1′-(3-((3,4-dimethoxyphenyl)sulfonyl)-6- (methylthio)quinolin-4-yl)-[1,4′- bipiperidin]-4-ol

 

154

3-((3,4-dimethoxyphenyl)sulfonyl)-4-(4- methyl-1,4-diazepan-1-yl)-6- (methylthio)quinoline

 

155

ethyl 4-(dibutylamino)-3-((4- methoxyphenyl)sulfonyl)quinoline-6- carboxylate

 

156

ethyl 4-(bis(2-hydroxyethyl)amino)-3-((4- methoxyphenyl)sulfonyl)quinoline-6- carboxylate

 

157

ethyl 4-([1,4′-bipiperidin]-1′-yl)-3-((4- butoxyphenyl)sulfonyl)quinoline-6- carboxylate

 

158

ethyl 3-((4-butoxyphenyl)sulfonyl)-4-(4- methyl-1,4-diazepan-1-yl)quinoline-6- carboxylate

 

159

4-([1,4′-bipiperidin]-1′-yl)-3-((4- butoxyphenyl)sulfonyl)-6- (methylthio)quinoline

 

160

3-((4-butoxyphenyl)sulfonyl)-4-(4- methyl-1,4-diazepan-1-yl)-6- (methylthio)quinoline

 

161

ethyl 3-((4-butoxyphenyl)sulfonyl)-4-(4- hydroxy-[1,4′-bipiperidin]-1′- yl)quinoline-6-carboxylate

 

162

1′-(3-((4-butoxyphenyl)sulfonyl-6- (methylthio)quinolin-4-yl)-[1,4′- bipiperidin]-4-ol

 

163

3-((4-butoxyphenyl)sulfonyl)-4-(4- methyl-1,4-diazepan-1-yl)-6- (methylsulfinyl)quinoline

 

164

3-((4-butoxyphenyl)sulfonyl)-4-(4- methyl-1,4-diazepan-1-yl)-6- (methylsulfonyl)quinoline

 

165

N,N-diethyl)l-3-((4- methoxyphenyl)sulfonyl-4-(4-methyl- 1,4-diazepan-1-yl)quinoline-6- carboxamide

 

166

N-(2-(diethyl)lamino)ethyl)-3-((4- methoxyphenyl)sulfonyl)-4-(4-methyl- 1,4-diazepan-1-yl)quinoline-6- carboxamide

 

167

4-([1,4′-bipiperidin]-1′-yl)-3-((4- butoxyphenyl)sulfonyl)-6- (methylsulfinyl)quinoline

 

168

1′-(3-((4-butoxyphenyl)sulfonyl)-6- (methylsulfinyl)quinolin-4-yl)-[1,4′- bipiperidin]-4-ol

 

169

4-([1,4′-bipiperidin]-1′-yl)-3-((4- butoxyphenyl)sulfonyl)-6- (methylsulfonyl)quinoline

 

170

1′-(3-((4-butoxyphenyl)sulfonyl)-6- (methylsulfonyl)quinolin-4-yl)-[1,4′- bipiperidin]-4-ol

 

171

ethyl 3-((4-methoxyphenyl)sulfonyl)-4- (4-(4-methylpiperazin-1-yl)piperidin-1- yl)quinoline-6-carboxylate

 

172

ethyl 3-((4-butoxyphenyl)sulfonyl-4-(4- (4-methylpiperazin-1-yl)piperidin-1- yl)quinoline-6-carboxylate

 

173

ethyl 4-(4-(azepan-1-yl)piperidin-1-yl)-3- ((4-ethoxyphenyl)sulfonyl)quinoline-6- carboxylate

 

174

ethyl 4-(3-hydroxy-[1,4′-bipiperidin]-1′- yl)-3-((4- methoxyphenyl)sulfonyl)quinoline-6- carboxylate

 

175

ethyl 4-(4-(hydroxymethyl)-[1,4′- bipiperidin]-1′-yl)-3-((4- methoxyphenyl)sulfonyl)quinoline-6- carboxylate

 

176

ethyl 4-(4-(azepan-1-yl)piperidin-1-yl)-3- ((4-butoxyphenyl)sulfonyl)quinoline-6- carboxylate

 

177

ethyl 3-((4-butoxyphenyl)sulfonyl)-4-(3- hydroxy-[1,4′-bipiperidin]-1′- yl)quinoline-6-carboxylate

 

178

ethyl 3-((4-butoxyphenyl)sulfonyl)-4-(4- (hydroxymethyl)-[1,4′-bipiperidin]-1′- yl)quinoline-6-carboxylate

 

179

ethyl 3-((4-methoxyphenyl)sulfonyl)-4- (4-(2-(piperidin-1-yl)ethyl)-1,4-diazepan- 1-yl)quinoline-6-carboxylate

 

180

ethyl 3-((4-methoxyphenyl)sulfonyl)-4- (4-(2-(pyrrolidin-1-yl)ethyl)-1,4- diazepan-1-yl)quinoline-6-carboxylate

 

181

ethyl 3-((4-butoxyphenyl)sulfonyl)-4-(4- (2-(piperidin-1-yl)ethyl)-1,4-diazepan-1- yl)quinoline-6-carboxylate

 

182

ethyl 3-((4-butoxyphenyl)sulfonyl)-4-(4- (2-(pyrrolidin-1-yl)ethyl)-1,4-diazepan-1- yl)quinoline-6-carboxylate

 

183

ethyl 3-((4-methoxyphenyl)sulfonyl)-4- (1H-1,2,4-triazol-1-yl)quinoline-6- carboxylate

 

184

ethyl 3-((4-methoxyphenyl)sulfonyl)-4- (1H-1,2,3-triazol-1-yl)quinoline-6- carboxylate

 

185

ethyl 3-((4-methoxyphenyl)sulfonyl)-4- (1H-tetrazol-1-yl)quinoline-6-carboxylate

 

186

ethyl 3-((4-butoxyphenyl)sulfonyl)-4- (1H-tetrazol-1-yl)quinoline-6-carboxylate

 

187

4-(3-((4-butoxyphenyl)sulfonyl)-6- (trifluoromethoxy)quinolin-4- yl)thiomorpholine

 

188

ethyl 3-((4-butoxyphenyl)sulfonyl)-4- (1H-1,2,4-triazol-1-yl)quinoline-6- carboxylate

 

189

ethyl 3-((4-butoxyphenyl)sulfonyl)-4- (1H-1,2,3-triazol-1-yl)quinoline-6- carboxylate

 

190

ethyl 3-((4-butoxyphenyl)sulfonyl)-4- (1H-1,2,4-triazol-1-yl)quinoline-6- carboxylate

 

191

ethyl 3-((4-butoxyphenyl)sulfonyl)-4- thiomorpholinoquinoline-6-carboxylate

 

192

3-((4-butoxyphenyl)sulfonyl)-N- isopropyl-4-(4-methyl-1,4-diazepan-1- yl)quinoline-6-carboxamide

 

193

3-((4-butoxyphenyl)sulfonyl)-4-(4- methyl-1,4-diazepan-1-yl)-N- ((4R,5S,6R)-2,4,5-trihydroxy-6- (hydroxymethyl)tetrahydro-2H-pyran-3- yl)quinoline-6-carboxamide

 

194

ethyl 3-((4-butoxyphenyl)sulfonyl)-4- (1H-imidazol-1-yl)quinoline-6- carboxylate

 

195

ethyl 3-((4-butoxyphenyl)sulfonyl)-4-(1- oxidothiomorpholino)quinoline-6- carboxylate

 

196

ethyl 3-((4-butoxyphenyl)sulfonyl)-4- (1,1-dioxidothiomorpholino)quinoline-6- carboxylate

 

197

4-(3-((4-butoxyphenyl)sulfonyl)-6- (trifluoromethoxy)quinolin-4- yl)thiomorpholine 1-oxide

 

198

4-(3-((4-butoxyphenyl)sulfonyl)-6- (trifluoromethoxy)quinolin-4- yl)thiomorpholine 1,1-dioxide

 

199

3-((4-butoxyphenyl)sulfonyl)-N,N- diethyl)l-4-(4-methyl-1,4-diazepan-1- yl)quinoline-6-carboxamide

 

200

3-((4-butoxyphenyl)sulfonyl)-N-(2- hydroxyethyl)-4-(4-methyl-1,4-diazepan- 1-yl)quinoline-6-carboxamide

 

201

4-([1,4′-bipiperidin]-1′-yl)-3-((4- butoxyphenyl)sulfonyl)-N,N- diethyl)quinoline-6-carboxamide

 

202

4-([1,4′-bipiperidin]-1′-yl)-3-((4- butoxyphenyl)sulfonyl)-N-(2- hydroxyethyl)quinoline-6-carboxamide

 

203

4-([1,4′-bipiperidin]-1′-yl)-3-((4- butoxyphenyl)sulfonyl)-N- ethyl)quinoline-6-carboxamide

 

204

4-(1H-imidazol-1-yl)-3-((4- methoxyphenyl)sulfonyl)-N-((4R,5S,6R)- 2,4,5-trihydroxy-6- (hydroxymethyl)tetrahydro-2H-pyran-3- yl)quinoline-6-carboxamide

 

205

4-(1H-benzo[d][1,2,3]triazol-1-yl)-3-((4- methoxyphenyl)sulfonyl)-N-((4R,5S,6R)- 2,4,5-trihydroxy-6- (hydroxymethyl)tetrahydro-2H-pyran-3- yl)quinoline-6-carboxamide

 

206

3-((4-butoxyphenyl)sulfonyl)-6- (methylthio)-4-(4-(2-(piperidin-1- yl)ethyl)-1,4-diazepan-1-yl)quinoline

 

207

3-((4-butoxyphenyl)sulfonyl)-6- (methylthio)-4-(4-(2-(pyrrolidin-1- yl)ethyl)-1,4-diazepan-1-yl)quinoline

 

208

1′-(3-((4-butoxyphenyl)sulfonyl)-6- (methylsulfinyl)quinolin-4-yl)-[1,4′- bipiperidin]-3-ol

 

209

3-((4-butoxyphenyl)sulfonyl)-6- (methylsulfinyl)-4-(4-(2-(piperidin-1- yl)ethyl)-1,4-diazepan-1-yl)quinoline

 

210

3-((4-butoxyphenyl)sulfonyl)-6- (methylsulfinyl)-4-(4-(2-(pyrrolidin-1- yl)ethyl)-1,4-diazepan-1-yl)quinoline

 

211

ethyl 3-((4-butoxyphenyl)sulfonyl)-4-(4- (4-methyl-1,4-diazepan-1-yl)piperidin-1- yl)quinoline-6-carboxylate

 

212

ethyl 3-((4-butoxyphenyl)sulfonyl)-4-(4- morpholinopiperidin-1-yl)quinoline-6- carboxylate

 

213

ethyl 3-((4-butoxyphenyl)sulfonyl)-4-(4- (4-fluorophenyl)piperazin-1-yl)quinoline- 6-carboxylate

 

214

ethyl 3-((4-butoxyphenyl)sulfonyl)-4-(4- (4-(2-hydroxyethyl)piperazin-1- yl)piperidin-1-yl)quinoline-6-carboxylate

 

215

ethyl 3-((4-butoxyphenyl)sulfonyl)-4-(4- phenyl-[1,4′-bipiperidin]-1′-yl)quinoline- 6-carboxylate

 

216

ethyl 4-([1,4′:1′,4″-terpiperidin]-1″-yl)-3- ((4-butoxyphenyl)sulfonyl)quinoline-6- carboxylate

 

217

ethyl 3-((4-butoxyphenyl)sulfonyl)-4-(4- thiomorpholinopiperidin-1-yl)quinoline- 6-carboxylate

 

218

3-((4-(heptyloxy)phenyl)sulfonyl)-4-(4- methyl-1,4-diazepan-1-yl)-6- (methylthio)quinoline

 

219

4-([1,4′-bipiperidin]-1′-yl)-3-((4- (heptyloxy)phenyl)sulfonyl)-6- (methylthio)quinoline

 

220

3-((4-(heptyloxy)phenyl)sulfonyl)-4-(4- methyl-1,4-diazepan-1-yl)-6- (methylsulfinyl)quinoline

 

221

4-([1,4′-bipiperidin]-1′-yl)-3-((4- (heptyloxy)phenyl)sulfonyl)-6- (methylsulflnyl)quinoline

 

222

1′-(3-((4-butoxyphenyl)sulfonyl)-6- (methylthio)quinolin-4-yl)-[1,4′- bipiperidin]-3-ol

 

223

1′-(3-((4-(heplyloxy)phenyl)sulfonyl)-6- (methylthio)quinolin-4-yl-[1,4′- bipiperidin]-4-ol

 

224

1′-(3-((4-(heptyloxy)phenyl)sulfonyl)-6- (methylsulfinyl)quinolin-4-yl)-[1,4′- bipiperidin]-4-ol

 

225

ethyl 3-((4-methoxyphenyl)sulfonyl)-4- ((4-methylpiperazin-1- yl)amino)quinoline-6-carboxylate

 

226

3-((4-methoxyphenyl)sulfonyl)-N-(4- methylpiperazin-1-yl)-6- (methylthio)quinolin-4-amine

 

227

3-((4-methoxyphenyl)sulfonyl)-N-(4- methylpiperazin-1-yl)-6- (methylsulfinyl)quinolin-4-amine

 

228

3-((4-methoxyphenyl)sulfonyl)-N-(4- methylpiperazin-1-yl)-6- (methylsulfonyl)quinolin-4-amine

 

229

4-(1-(3-((4-butoxyphenyl)sulfonyl)-6- (methylthio)quinolin-4- yl)piperidin-4-yl)morpholine

 

230

2-(4-(1-(3-((4-butoxyphenyl)sulfonyl)-6- (methylthio)quinolin-4-yl)piperidin-4- yl)piperazin-1-yl)ethan-1-ol

 

231

4-([1,4′:1′,4″-terpiperidin]-1″-yl)-3-((4- butoxyphenyl)sulfonyl)-6- (methylthio)quinoline

 

232

1′-(3-((4-butoxyphenyl)sulfonyl-6- (methylthio)quinolin-4-yl)-4- phenyl-[1,4′-bipiperidin]-4-ol

 

233

3-((4-butoxyphenyl)sulfonyl)-4-(4-(4-(4- fluorophenyl)piperazin-1-yl)piperidin-1- yl)-6-(methylthio)quinoline

 

234

3-((4-butoxyphenyl)sulfonyl)-4-(4-(4- methyl-1,4-diazepan-1-yl)piperidin-1-yl)- 6-(methylthio)quinoline

 

235

4-(1-(3-((4-butoxyphenyl)sulfonyl)-6- (methylsulfinyl)quinolin-4-yl)piperidin-4- yl)morpholine

 

236

2-(4-(1-(3-((4-butoxyphenyl)sulfonyl)-6- (methylsulfinyl)quinolin-4-yl)piperidin-4- yl)piperazin-1-yl)ethan-1-ol

 

237

4-([1,4′:1′,4″-terpiperidin]-1″-yl)-3-((4- butoxyphenyl)sulfonyl)-6- (methylsulfinyl)quinoline

 

238

1′-(3-((4-butoxyphenyl)sulfonyl)-6- (methylsulfinyl)quinolin-4-yl)-4-phenyl- [1,4′-bipiperidin]-4-ol

 

239

3-((4-butoxyphenyl)sulfonyl)-4-(4-(4-(4- fluorophenyl)piperazin-1-yl)piperidin-1- yl)-6-(methylsulfinyl)quinoline

 

240

(1′-(3-((4-butoxyphenyl)sulfonyl)-6- (methylsulfinyl)quinolin-4-yl)-[1,4′- bipiperidin]-4-yl)methanol

 

241

3-((4-butoxyphenyl)sulfonyl)-4-(4-(4- methyl-1,4-diazepan-1-yl)piperidin-1-yl)- 6-(methylsulfinyl)quinoline

 

242

N,N-diethyl)l-2-(4-((4-(4-methyl-1,4- diazepan-1-yl)-6-(methylthio)quinolin-3- yl)sulfonyl)phenoxy)ethan-1-amine

 

243

4-(1-(3-((4-butoxyphenyl)sulfonyl)-6- (methylthio)quinolin-4-yl)-piperidin-4- yl)thiomoroholine

 

244

ethyl 3-((4-butoxyphenyl)sulfonyl)-4-(4- (1-oxidothiomoroholino)piperidin-1- yl)quinoline-6-carboxylate

 

245

4-(1-(3-((4-butoxyphenyl)sulfonyl)-6- (methylsulfinyl)quinolin-4-yl)piperidin-4- yl)thiomorpholine

 

246

3-((4-(heptyloxy)phenyl)sulfonyl)-4-(4- (4-methylpiperazin-1-yl)piperidin-1-yl)- 6-(methylthio)quinoline

 

247

1′-(3-((4-(heptyloxy)phenyl)sulfonyl)-6- (methylthio)quinolin-4-yl)-[1,4′- bipiperidin]-3-ol

 

248

3-((4-(heptyloxy)phenyl)sulfonyl)-6- (methylthio)-4-(4-(2-(piperidin-1- yl)ethyl)-1,4-diazepan-1-yl)quinoline

 

249

3-((4-(heptyloxy)phenyl)sulfonyl)-4-(4- (4-methyl-1,4-diazepan-1-yl)piperidin-1- yl)-6-(methylthio)quinoline

 

250

2-(4-(1-(3-((4- (heptyloxy)phenyl)sulfonyl)-6- (methylthio)quinolin-4-yl)piperidin-4- yl)piperazin-1-yl)ethan-1-ol

 

251

4-([1,4′:1′,4″-terpiperidin]-1″-yl)-3-((4- (heptyloxy)phenyl)sulfonyl)-6- (methylthio)quinoline

 

252

3-((4-(heptyloxy)phenyl)sulfonyl)-4-(4- methylpiperazin-1-yl)-6- (methylthio)quinoline

 

253

3-((4-(heptyloxy)phenyl)sulfonyl-4-(4- (4-methylpiperazin-1-yl)piperidin-1-yl)- 6-(methylsulfinyl)quinoline

 

254

1′-(3-((4-(heptyloxy)phenyl)sulfonyl)-6- (methylsulfinyl)quinolin-4-yl)-[1,4′- bipiperidin]-3-ol

 

255

3-((4-(heptyloxy)phenyl)sulfonyl)-6- (methylsulfinyl)-4-(4-(2-(piperidin-1- yl)ethyl)-1,4-diazepan-1-yl)quinoline

 

256

3-((4-(heplyloxy)phenyl)sulfonyl)-4-(4- (4-methyl-1,4-diazepan-1-yl)piperidin-1- yl)-6-(methylsulfinyl)quipoline

 

257

2-(4-(1-(3-((4- (heptyloxy)phenyl)sulfonyl)-6- (methylsulfinyl)quinolin-4-yl)piperidin-4- yl)piperazin-1-yl)ethan-1-ol

 

258

4-([1,4′:1′,4″-terpiperidin]-1″-yl)-3-((4- (heptyloxy)phenyl)sulfonyl)-6- (methylsulfinyl)quinoline

 

259

3-((4-heptyloxy)phenyl)sulfonyl)-4-(4- methylpiperazin-1-yl)-6- (methylsulfinyl)quinoline

 

260

3-((4-methoxyphenyl)sulfonyl)-4-((4- methylpiperazn-1-yl)amino)-N- ((4R,5S,6R)-2,4,5-trihydroxy-6- (hydroxymethyl)tetrahydro-2H-pyran-3- yl)quinoline-6-carboxamide

 

262

1′-(3-((4-(heptyloxy)phenyl)sulfonyl)-6- (methylthio)quinolin-4-yl)-4-phenyl- [1,4′-bipiperidin]-4-ol

 

263

1′-(3-((4-(heptyloxy)phenyl)sulfonyl)-6- (methylsulfinyl)quinolin-4-yl)-4-phenyl- [1,4′-bipiperidin]-4-ol

 

264

3-((4-(decyloxy)phenyl)sulfonyl)-4-(4-(4- methylpiperazin-1-yl)piperidin-1-yl)-6- (methylsulfinyl)quinoline

 

265

1′-(3-((4-(decyloxy)phenyl)sulfonyl)-6- (methylsulfinyl)quinolin-4-yl)-[1,4′- bipiperidin]-3-ol

 

266

3-((4-(decyloxy)phenyl)sulfonyl)-6- (methylsulfinyl)-4-(4-(2-(piperidin-1- yl)ethyl)-1,4-diazepan-l-yl)quinoline

 

267

3-((4-(decyloxy)phenyl)sulfonyl)-4-(4-(4- methyl-1,4-diazepan-1-yl)piperidin-1-yl)- 6-(methylsulfinyl)quinoline

 

268

2-(4-(1-(3-((4- (decyloxy)phenyl)sulfonyl-6- methylsulfinyl)quinolin-4-yl)piperidin-4- yl)piperazin-1-yl)ethan-1-ol

 

269

4-([1,4′:1′,4″-terpiperidin]-1″-yl)-3-((4- (decyloxy)phenyl)sulfonyl-6- (methylsulfinyl)quinoline

 

270

1′-(3-((4-(decyloxy)phenyl)sulfonyl)-6- (methylsulfinyl)quinolin-4-yl)-4-phenyl- [1,4′-bipiperidin]-4-ol

 

271

3-((4-(heptyloxy)phenyl)sulfonyl)-4-(4- (4-(2-mPEGoxyethyl)piperazin-1- yl)piperidin-1-yl)-6- (methylthio)quinoline

 

272

3-((4-(heptyloxy)phenyl)sulfonyl)-6- (methylthio)-4-(4-(2-(pyrrolidin-1- yl)ethyl)piperazin-1-yl)quinoline

 

273

3-((4-(heptyloxy)phenyl)sulfonyl)-4-(4- (1-methylpiperidin-4-yl)piperazin-1-yl)- 6-(methylthio)quinoline

 

274

4-(4-(1-benzylpyrrolidin-3-yl)piperazin- 1-yl)-3-((4-(heptyloxy)phenyl)sulfonyl)- 6-(methylthio)quinoline

 

275

4-(4-((1-benzylpiperidin-4- yl)methyl)piperazin-1-yl)-3- ((4-(heptyloxy)phenyl)sulfonyl)-6- (methylthio)quinoline

 

276

3-((4-(heptyloxy)phenyl)sulfonyl)-6- (methylsulfinyl)-4-(4-(2-(pyrrolidin-1- yl)ethyl)piperazin-1-yl)quinoline

 

277

4-(4-(1-ethylpiperidin-4-yl)piperazin-1- yl)-3-((4-(heptyloxy)phenyl)sulfonyl)-6- (methylsulfinyl)quinoline

 

278

4-(4-(1-benzylpyrrolidin-3-yl)piperazin-1- yl)-3-((4-(heptyloxy)phenyl)sulfonyl)- 6-(methylsulfinyl)quinoline

 

279

4-(4-((1-benzylpiperidin-4- yl)methyl)piperazin-1-yl)-3- ((4-(heptyloxy)phenyl)sulfonyl)-6- (methylsulfinyl)quinoline

 

280

3-((4-(heptyloxy)phenyl)sulfonyl)-4-(4- (4-(2-mPEGoxyethyl)piperazin-1- yl)piperidin-1-yl)-6- (methylsulfinyl)quinoline

 

281

3-((4-(heptyloxy)phenyl)sulfonyl)-6- (methylthio)-4-(4-(2-(piperidin-1- yl)ethyl)piperazin-1-yl)quinoline

 

282

3-((4-(heptyloxy)phenyl)sulfonyl)-6- (methylsulfinyl)-4-(4-(2-(piperidin-1- yl)ethyl)piperazin-1-yl)quinoline

 

283

3-((4-(decyloxy)phenyl)sulfonyl)-4-(4-(1- ethylpiperidin-4-yl)piperazin-1-yl)-6- (methylsulfinyl)quinoline

 

284

2-(4-(1-(3-((4-((3,7- dimethyloctyl)oxy)phenyl)sulfonyl)-6- (methylsulfinyl)quinolin-4-yl)piperidin-4- yl)piperazin-1-yl)ethan-1-ol

 

285

3-((4-(decyloxy)phenyl)sulfonyl)-4-(4-(4- methylpiperazin-1-yl)-[1,4′-bipiperidin]- 1′-yl)-6-(methylsulfinyl)quinoline

 

286

4-(1′-(3-((4-(decyloxy)phenyl)sulfonyl)- 6-(methylsulfinyl)quinolin-4-yl)-[1,4′- bipiperidin]-4-yl)morpholine

 

287

3-((4(decyloxy)phenyl)sulfonyl)-4-(4-(4- methyl-1,4-diazepan-1-yl)-[1,4′- bipiperidin]-1yl)-6- (methylsulfinyl)quinoline

 

288

1″-(3-((4-(decyloxy)phenyl)sulfonyl)-6- (methylsulfinyl)quinolin-4-yl-[1,4′:1′,4″- terpiperidin]-3-ol

 

289

4-([1,4′:1,4″-terpiperidin]-1″-yl)-3-((4- ((3,7- dimethyloctyl)oxy)phenyl)sulfonyl)-6- (methylsulfinyl)quinoline

 

290

4-([1,4′:1′,4″-terpiperidin]-1″-yl)-3-((4- (decyloxy)-3-fluorophenyl)sulfonyl)-6- (methylsulfinyl)quinoline

 

291

2-(4-(1-(3-((4-(decyloxy)-3- fluorophenyl)sulfonyl)-6- (methylsulfinyl)quinolin-4-yl)piperidin-4- yl)piperazin-1-yl)ethan-1-ol

 

292

2-(4-(1′-(3-((4- (decyloxy)phenyl)sulfonyl-6- (methylsulfinyl)quinolin-4-yl)-[1,4′- bipiperidin]-4-yl)piperazin-1-yl)ethan-1- ol

 

293

N,N-diethyl)l-6,7-dimethoxy-3-((4- methoxyphenyl)sulfonyl)quinolin- amine

 

294

N-ethyl-N-isopropyl-6,7-dimethoxy-3- ((4-methoxyphenyl)sulfonyl)quinolin-4- amine

 

295

N,N-dibutyl-6,7-dimethoxy-3-((4- methoxyphenyl)sulfonyl)quinolin-4- amine

 

296

N1-(6,7-dimethoxy-3-((4- methoxyphenyl)sulfonyl)quinolin-4-yl)- N1,N2,N2-triethylethane-1,2-diamine

 

297

N1-(6,7-dimethoxy-3-((4- methoxyphenyl)sulfonyl)quinolin-4-yl)- N2,N2-diethyl)lethane-1,2-diamine

 

298

N1-(6,7-dimethoxy-3-((4- methoxyphenyl)sulfonyl)quinolin-4- yl)-N3,N3-diethyl)lpropane-1,3-diamine

 

299

N1-(6,7-dimethoxy-3-((4- methoxyphenyl)sulfonyl)quinolin-4- yl)-N4,N4-diethyl)lbutane-1,4-diamine

 

300

N3-(6,7-dimethoxy-3-((4- methoxyphenyl)sulfonyl)quinolin-4- yl)-N1,N1-diethyl)lbutane-1,3-diamine

 

301

2-(4-(6,7-dimethoxy-3-((4- methoxyphenyl)sulfonyl)quinolin-4- yl)piperazin-1-yl)ethan-1-ol

 

302

3-(4-(6,7-dimethoxy-3-((4- methoxyphenyl)sulfonyl)quinolin-4- yl)piperazin-1-yl)-N,N-diethyl)lpropan-1- amine

 

303

1-(6,7-dimethoxy-3-((4- methoxyphenyl)sulfonyl)quinolin-4- yl)piperidin-4-ol

 

304

(1-(6,7-dimethoxy-3-((4- methoxyphenyl)sulfonyl)quinolin-4- yl)piperidin-3-yl)methanol

 

305

1-(6,7-dimethoxy-3-((4- methoxyphenyl)sulfonyl)quinolin-4- yl)pyrrolidin-3-ol

 

306

6,7-dimethoxy-3-((4- methoxyphenyl)sulfonyl)-4-((1S,4S)-5- methyl-2,5-diazabicyclo[2,2,1]heptan-2- yl)quinoline

 

307

4-(6,7-dimethoxy-3-((4- methoxyphenyl)sulfonyl)quinolin-4-yl)- N,N-dimethyl-1,4-diazepane-1- carboxamide

 

308

1-(6,7-dimethoxy-3-((4- methoxyphenyl)sulfonyl)quinolin-4-yl)- 4-phenylpiperidin-4-ol

 

309

methyl 4-(1-(6,7-dimethoxy-3-((4- methoxyphenyl)sulfonyl)quinolin-4- yl)piperidin-4-yl)benzoate

 

310

4-(1-(6,7-dimethoxy-3-((4- methoxyphenyl)sulfonyl)quinolin-4- yl)piperidin-4-yl)-N-methylbenzamide

 

311

6,7-dimethoxy-4-(4-(4- methoxyphenyl)piperidin-1-yl)-3-((4- methoxyphenyl)sulfonyl)quinoline

 

312

6,7-dimethoxy-3-((4- methoxyphenyl)sulfonyl)-4-(4-(4- (pyrrolidin-1-ylmethyl)phenyl)piperidin- 1-yl)quinoline

 

313

6,7-dimethoxy-3-((4- methoxyphenyl)sulfonyl)-4-(3- phenylpyrrolidin-1-yl)quinoline

 

314

4-(3-(benzo[d][1,3]dioxol-5- yl)pyrrolidin-1-yl)-6,7-dimethoxy-3-((4- methoxyphenyl)sulfonyl)quinoline

 

315

6,7-dimethoxy-3-((4- methoxyphenyl)sulfonyl)-4-(4- phenylpiperazin-1-yl)quinoline

 

316

6,7-dimethoxy-4-(4-(4- methoxyphenyl)piperazin-1-yl)-3-((4- methoxyphenyl)sulfonyl)quinoline

 

317

ethyl 4-(4-(6,7-dimethoxy-3-((4- methoxyphenyl)sulfonyl)quinolin-4- yl)piperazin-1-yl)benzoate

 

318

4-(6,7-dimethoxy-3-((4- methoxyphenyl)sulfonyl)quinolin-4-yl)- 1-(4-methoxyphenyl)piperazin-2-one

 

319

N-cyclohexyl-4-(4-(6,7-dimethoxy-3-((4- methoxyphenyl)sulfonyl)quinolin-4- yl)piperazin-1-yl)benzamide

 

320

4-([1,4′-bipiperidin]-1′-yl)-6,7- dimethoxy-3-((4- methoxyphenyl)sulfonyl)quinoline

 

321

1-(1-(6,7-dimethoxy-3-((4- methoxyphenyl)sulfonyl)quinolin-4- yl)piperidin-4-yl)pyrrolidin-2-one

 

322

(1-(1-(6,7-dimethoxy-3-((4- methoxyphenyl)sulfonyl)quinolin-4- yl)piperidin-4-yl)pyrrolidin-2- yl)methanol

 

323

2-(4-(6,7-dimethoxy-3-((4- methoxyphenyl)sulfonyl)quinolin-4-yl)- 1,4-diazepan-1-yl)ethan-1-ol

 

324

7-(6,7-dimethoxy-3-((4- methoxyphenyl)sulfonyl)quinolin-4-yl)- 1-isobutyldecahydropyrido[4,3- e][1,4]oxazepine

 

325

1-((4-(6,7-dimethoxy-3-((4- methoxyphenyl)sulfonyl)quinolin-4-yl)- 1,4-diazepan-1-yl)methyl)cyclopentan-1- ol

 

326

6,7-dimethoxy-3-((4- methoxyphenyl)sulfonyl)-4-(4-(oxelan-3- yl)-1,4-diaxepan-1-yl)quinoline

 

327

6-chloro-2-(4-(6,7-dimethoxy-3-((4- methoxyphenyl)sulfonyl)quinolin-4-yl)- 1,4-diazepan-1-yl)benzo[d]thiazole

 

328

1-(6,7-dimethoxy-3-((4- methoxyphenyl)sulfonyl)quinolin-4-yl)- 4-methyl-1,4-diazepan-5-one

 

329

6,7-dimethoxy-3-((4- methoxyphenyl)sulfonyl)-4-(4- (tetrahydro-2H-thiopyran-4-yl)-1,4- diazepan-1-yl)quinoline

 

330

4-(4-(6,7-dimethoxy-3-((4- methoxyphenyl)sulfonyl)quinolin-4-yl)- 1,4-diazepan-1-yl)tetrahydro-2H- thiopyran 1,1-dioxide

 

331

4-([1,4′-bipiperidin]-1′-yl)-3-((4- methoxyphenyl)sulfonyl)-N,N- dimethylquinoline-6-carboxamide

 

332

3-((4-methoxyphenyl)sulfonyl)-N,N- dimethyl-4-(4-(2-oxopyrrolidin-1- yl)piperidin-1-yl)quinoline-6-carboxamid

 

333

4-(4-(2-(dimethylamino)-2-oxoethyl)-1,4- diazepan-1-yl)-3-((4- methoxyphenyl)sulfonyl)-N,N- dimethyl)quinoline-6-carboxamide

 

334

4-([1,4′-bipiperidin]-1′-yl)-3-((4- methoxyphenyl)sulfonyl)-N- methylquinoline-6-carboxamide

 

335

3-((4-methoxyphenyl)sulfonyl)-N- methyl-4-(4-methyl-1,4-diazepan-1- yl)quinoline-6-carboxamide

 

336

4-(4-(2-(hydroxymethyl)pyrrolidin-1- yl)piperidin-1-yl)-3-((4- methoxyphenyl)sulfonyl)-N- methylquinoline-6-carboxamide

 

337

4([1,4′-bipiperidin]-1′-yl)-N-(2- (diethyl)lamino)ethyl)-3-((4- methoxyphenyl)sulfonyl)quinoline-6- carboxamide

 

338

N-(2-(diethyl)lamino)ethyl)-4-(1- isobutyloctahydropyrido[4,3- e][1,4]oxazepin-7(5H)-yl)-3-((4- methoxyphenyl)sulfonyl)quinoline-6- carboxamide

 

339

2-(4-(1-(3-((4- (dodecyloxy)phenyl)sulfonyl)-6- (methylsulfinyl)quinolin-4-yl)piperidin-4- yl)piperazin-1-yl)ethan-1-ol

 

340

2-(4-(1′-(3-((4- (dodecyloxy)phenyl)sulfonyl)-6- (methylsulfinyl)quinolin-4-yl)-[1,4′- bipiperidin]-4-yl)piperazin-1-yl)ethan-1- ol

 

341

3-((4-(dodecyloxy)phenyl)sulfonyl)-4-(4- (4-methylpiperazin-1-yl)-[1,4′- bipiperidin]-1′-yl)-6- (methylsulfinyl)quinoline

 

342

4-([1,4′:1′,4″-terpiperidin]-1″-yl)-3-((4- (dodecyloxy)phenyl)sulfonyl)-6- (methylsulfinyl)quinoline

 

343

1″-(3-((4-(dodecyloxy)phenyl)sulfonyl)- 6-(methylsulfinyl)quinolin- 4-yl)-[1,4′:1′,4″-terpiperidin]-3-ol

 

344

2-(4-(1-(6-(methylsulfinyl)-3-((4- (tetradecyloxy)phenyl)sulfonyl)quinolin- 4-yl)piperidin-4-yl)piperazin-1-yl)ethan- 1-ol

 

345

2-(4-(1′-(6-(methylsulfinyl)-3-((4- (tetradecyloxy)phenyl)sulfonyl)quinolin- 4-yl)-[1,4′-bipiperidin]-4-yl)piperazin-1- yl)ethan-1-ol

 

346

4-(4-(4-methylpiperazin-1-yl)-[1,4′- bipiperidin]-1′-yl)-6-(methylsulfinyl)-3- ((4- (tetradecyloxy)phenyl)sulfonyl)quinoline

 

347

4-([1,4′:1′,4″-terpiperidin]-1″-yl)-6- (methyl(λ1-oxidanyl)-λ3-sulfanyl)-3- ((4-(tetradecyloxy)phenyl)sulfonyl)quinoline

 

348

1″-(6-(methyl(λ1-oxidanyl)-λ3-sulfanyl)- 3-((4- (tetradecyloxy)phenyl)sulfonyl)quinolin- 4-yl)-[1,4′:1,4″-terpiperidin]-3-ol

 

349

1-(1-(3-((4-butoxyphenyl)sulfonyl)-6- (methylthio)quinolin-4-yl)piperidin-4- yl)pyrrolidin-2-one

 

350

(1-(1-(3-((4-butoxyphenyl)sulfonyl)-6- (methylthio)quinolin-4-yl)piperidin-4- yl)pyrrolidin-2-yl)methanol

 

351

2-(4-(3-((4-butoxyphenyl)sulfonyl)-6- (methylthio)quinolin-4-yl)-1,4-diazepan- 1-yl)ethan-1-ol

 

352

7-(3-((4-butoxyphenyl)sulfonyl)-6- (methylthio)quinolin-4-yl)-1- isobutyldecahydropyrido[4,3- e][1,4]oxazepine

 

353

4-(3-((4-butoxyphenyl)sulfonyl)-6- (methylthio)quinolin-4-yl)-N-(2,2,2- trifluoroethyl)-1,4-diazepane-1- sulfonamide

 

354

1-((4-(3-((4-butoxyphenyl)sulfonyl-6- (methylthio)quinolin-4-yl)-1,4-diazepan- 1-yl)methyl)cyclopentan-1-ol

 

355

3-((4-butoxyphenyl)sulfonyl)-6- (methylthio)-4-(4-(oxelan-3-yl)-1,4- diazepan-1-yl)quinoline

 

356

2-(4-(3-((4-butoxyphenyl)sulfonyl)-6- (methylthio)quinolin-4-yl)-1,4-diazepan- 1-yl)-6-chlorobenzo[d]thiazole

 

357

1-(3-((4-butoxyphenyl)sulfonyl)-6- (methylthio)quinolin-4-yl)-4-methyl-1,4- diazepan-5-one

 

358

3-((4-butoxyphenyl)sulfonyl)-6- (methylthio)-4-(4-(tetrahydro-2H- thiopyran-4-yl)-1,4-diaxepan-1- yl)quinoline

 

359

4-(4-(3-((4-butoxyphenyl)sulfonyl)-6- (methylthio)quinolin-4-yl)-1,4-diazepan- 1-yl)tetrahydro-2H-thiopyran 1,1-dioxide

 

360

3-((4-methoxyphenyl)sulfonyl)-N- methyl-4-methylamino)quinoline- 6-carboxamide

 

361

1-(1-(3-((4-butoxyphenyl)sulfonyl)-6- (methylthio)quinolin-4-yl)piperidin-4- yl)pyrrolidin-2-one

 

362

2-(4-(1-(3-((4-(dodecyloxy)-3- fluorophenyl)sulfonyl)-6- (methylsulfinyl)quinolin-4-yl)piperidin-4- yl)piperazin-1-yl)ethanol

 

363

4-([1,4′:1,4″-terpiperidin]-1″-yl)-3-((4- (dodecyloxy)-3-fluorophenyl)sulfonyl)-6- (methylsulfinyl)quinoline

 

364

1″-(3-((4-(dodecyloxy)-3- fluorophenyl)sulfonyl)-6- (methylsulfinyl)quinolin-4-yl)-[1,4′:1′,4″- terpiperidin]-3-ol

 

365

2-(4-(1-(3-((3-fluoro-4- (tetradecyloxy)phenyl)sulfonyl)-6- (methylsulfinyl)quinolin-4-yl)piperidin-4- yl)piperazin-1-yl)ethanol

 

366

4-([1,4′:1′,4″-terpiperidin]-1″-yl)-3-((3- fluoro-4-(tetradecyloxy)phenylsulfonyl)- 6-(methylsulfinyl)quinoline

 

367

1″-(3-((3-fluoro-4- (tetradecyloxy)phenyl)sulfonyl)-6- (methylsulfinyl)quinolin-4-yl)-[1,4′:1′,4″- terpiperidin]-3-ol

 

368

2-(4-(1′-(3-((4-(dodecyloxy)-3- fluorophenyl)sulfonyl)-6- (methylsulfinyl)quinolin-4-yl)-[1,4′- bipiperidin]-4-yl)piperazin-1-yl)ethanol

 

369

2-(4-(1′-(3-((3-fluoro-4- (tetradecyloxy)phenyl)sulfonyl)-6- (methylsulfinyl)quinolin-4-yl)-[1,4′- bipiperidin]-4-yl)piperazin-1-yl)ethanol

 

370

3-((4-(dodecyloxy)-3- fluorophenyl)sulfonyl)-4-(4-(4- methylpiperazin-1-yl)-[1,4′-bipiperidin]- 1′-yl)-6-(methylsulfinyl)quinoline

 

371

3-((3-fluoro-4- (tetradecyloxy)phenyl)sulfonyl)-4-(4-(4- methylpiperazin-1-yl)-[1,4′-bipiperidin]- 1′-yl)-6-(methylsulfinyl)quinoline

 

372

1″-(3-((4-(dodecyloxy)-3- fluorophenyl)sulfonyl)-6- (methylsulfinyl)quinolin-4-yl-[1,4′:1′,4″- terpiperidin]-4-ol

 

373

1″-(3-((3-fluoro-4- (tetradecyloxy)phenyl)sulfonyl)-6- (methylsulfinyl)quinolin-4-yl)-[1,4′:1′,4″- terpiperidin]-4-ol

 

374

1″-(3-((4-(dodecyloxy)phenyl)sulfonyl)- 6-(methylsulfinyl)quinolin-4-yl)- [1,4′:1′,4″-terpiperidin]-4-ol

 

375

1″-(6-(methylsulfinyl)-3-((4- (tetradecyloxy)phenyl)sulfonyl)quinolin- 4-yl)-[1,4′:1′,4″-terpiperidin]-4-ol

 

376

2-(4-(1-(3-((4- (hexadecyloxy)phenyl)sulfonyl)-6- (methylsulfinyl)quinolin-4-yl)piperidin-4- yl)piperazin-1-yl)ethanol

 

377

4-([1,4′:1′,4″-terpiperidin]-1″-yl)-3-((4- (hexadecyloxy)phenyl)sulfonyl)-6- (methylsulfinyl)quinoline

 

378

1″-(3-((4- (hexadecyloxy)phenyl)sulfonyl)-6- (methylsulfinyl)quinolin-4-yl)-[1,4′:1′,4″- terpiperidin]-3-ol

 

379

3-((4-methoxyphenyl)sulfonyl)-N,N- dimethyl-4-(4-methyl-1,4-diazepan-1- yl)quinoline-6-carboxamide

 

380

2-(4-(1-(6-(methylsulfinyl)-3-((4- (undecyloxy)phenyl)sulfonyl)quinolin-4- yl)piperidin-4-yl)piperazin-1-yl)ethanol

 

381

4-([1,4′:1′,4″-terpiperidin]-1″-yl)-6- (methylsulfinyl)-3-((4- (undecyloxy)phenyl)sulfonyl)quinoline

 

382

1″-(6-(methylsulfinyl)-3-((4- (undecyloxy)phenyl)sulfonyl)quinolin-4- yl)-[1,4,:1′,4″-terpiperidin]-4-ol

 

383

1″-(6-(methylsulfinyl)-3-((4- (undecyloxy)phenyl)sulfonyl)quinolin-4- yl)-[1,4′:1′,4″-terpiperidin]-3-ol

 

384

2-(4-((4-([1,4′:1′,4″-terpiperidin]-1″-yl)-6- (methylsulfinyl)quinolin-3- yl)sulfonyl)phenoxy)-N,N- diethyl)lethanamine

 

385

2-(4-(1′-(3-((4- (hexadecyloxy)phenyl)sulfonyl)-6- (methylsulfinyl)quinolin-4-yl)-[1,4′- bipiperidin]-4-yl)pipeiazin-1-yl)ethanol

 

386

3-((4-(hexadecyloxy)phenyl)sulfonyl)-4- (4-(4-methylpiperazin-1-yl)-[1,4′- bipiperidin]-1′-yl)-6- (methylsulfinyl)quinoline

 

387

2-(4-(1′-(3-((3-fluoro-4- (hexadecyloxy)phenyl)sulfonyl)-6- (methylsulfinyl)quinolin-4-yl-[1,4′- bipiperidin]-4-yl)piperazin-1-yl)ethanol

 

388

3-((3-fluoro-4- (hexadecyloxy)phenyl)sulfonyl)-4-(4-(4- methylpiperazin-1-yl)-[1,4′-bipiperidin]- 1′-yl)-6-(methylsulfinyl)quinoline

 

389

1′-(3-((3-fluoro-4- (hexadecyloxy)phenyl)sulfonyl)-6- (methylsulfinyl)quinolin-4-yl)-[1,4′:1′,4″- terpiperidin]-3-ol

 

390

4-(4-(4-ethylpiperazin-1-yl)-[1,4′- bipiperidin]-1′-yl)-3-((3-fluoro-4- (tetradecyloxy)phenyl)sulfonyl)-6- (methylsulfinyl)quinoline

 

391

3-((3-fluoro-4- (tetradecyloxy)phenyl)sulfonyl)-4-(4-(4- isopropylpiperazin-1-yl)-[1,4′- bipiperidin]-1′-yl)-6- (methylsulfinyl)quinoline

 

392

3-((3-fluoro-4- (tetradecyloxy)phenyl)sulfonyl)-4-(4-(4- methyl-1,4-diazepan-1-yl)-[1,4′- bipiperidin]-1′-yl)-6- (methylsulfinyl)quinoline

 

393

4-(1′-(3-((3-fluoro-4- (tetradecyloxy)phenyl)sulfonyl)-6- (methylsulfinyl)quinolin-4-yl)-[1,4′- bipiperidin]-4-yl)quinoline

 

394

4-(4-(4-(1-ethylpiperidin-4-yl)piperazin- 1-yl)piperidin-1-yl)-3-((3-fluoro-4- (tetradecyloxy)phenyl)sulfonyl)-6- (methylsulfinyl)quinoline

 

395

3-((2-fluoro-4- (tetradecyloxy)phenyl)sulfonyl)-4-(4-(4- methylpiperazin-1-yl)-[1,4′-bipiperidin]- 1′-yl)-6-(methylsulfinyl)quinoline

 

396

3-((3,5-difluoro-4- (tetradecyloxy)phenyl)sulfonyl)-4-(4-(4- methylpiperazin-1-yl)-[1,4′-bipiperidin]- 1′-yl)-6-(methylsulfinyl)quinoline

 

397

3-((2,3-difluoro-4- (tetradecyloxy)phenyl)sulfonyl)-4-(4-(4- methylpiperazin-1-yl)-[1,4′-bipiperidin]- 1′-yl)-6-(methylsulfinyl)quinoline

 

398

4-(4-(4-methylpiperazin-1-yl)-[1,4′- bipiperidin]-1′-yl)-6-(methylsulfinyl)-3- ((4- (octadecyloxy)phenyl)sulfonyl)quinoline

 

399

3-((3-fluoro-4- (octadecyloxy)phenyl)sulfonyl)-4-(4-(4- methylpiperazin-1-yl)-[1,4′-bipiperidin]- 1′-yl)-6-(methylsulfinyl)quinoline

 

400

4-(1′-(3-((3-fluoro-4- (tetradecyloxy)phenyl)sulfonyl)-6- (methylsulfinyl)quinolin-4-yl)-[1,4′- bipiperidin]-4-yl)thiomorpholine

 

401

1-(4-(1′-(3-((3-fluoro-4- (tetradecyloxy)phenyl)sulfonyl)-6- (methylsulfinyl)quinolin-4-yl)-[1,4′- bipiperidin]-4-yl)piperazin-1-ylethanone

 

402

3-((3-fluoro-4- (tetradecyloxylphenyl)sulfonyl)-4-(4-(4- methylpiperazin-1-yl)-[1,4′-bipiperidin]- 1′-yl)-6-(methylsulfonyl)quinoline

 

403

(S)-1″-(3-((4- (dodecyloxy)phenyl)sulfonyl)-6-((S)- methylsulfinyl)quinolin-4-yl)-[1,4′:1′,4″- terpiperidin]-3-ol

 

404

(S)-1″-(3-((4- (dodecyloxy)phenyl)sulfollyl)-6-((R)- methylsulfinyl)quinolin-4-yl)-[1,4′:1′,4″- terpiperidin]-3-ol

 

405

(R)-1″-(3-((4- (dodecyloxy)phenyl)sulfonyl)-6-((S)- methylsulfinyl)quinolin-4-yl)-[1,4′:1′,4″- terpiperidin]-3-ol

 

406

(R)-1″-(3-((4- (dodecyloxy)phenyl)sulfonyl)-6-((R)- methylsulfinyl)quinolin-4-yl)-[1,4′:1′,4″- terpiperidin]-3-ol

 

407

(R)-2-(4-(1′-(3-((4-(dodecyloxy)-3- fluorophenyl)sulfonyl)-6- (methylsulfinyl)quinolin-4-yl)-[1,4′- bipiperidin]-4-yl)piperazn-1-yl)ethanol

 

408

(S)-2-(4-(1′-(3-((4-(dodecyloxy)-3- fluorophenyl)sulfonyl)-6- (methylsulfinyl)quinolin-4-yl)-[1,4′- bipiperidin]-4-yl)piperazin-1-yl)ethanol

 

409

(R)-2-(4-(1′′-(3-((3-fluoro-4- (tetradecyloxy)phenyl)sulfonyl)-6- (methylsulfinyl)quinolin-4-yl)-[1,4′- bipiperidin]-4-yl)piperazin-1-yl)ethanol

 

410

(S)-2-(4-(1′-(3-((3-fluoro-4- (tetradecyloxy)phenyl)sulfonyl)-6- (methylsulfinyl)quinolin-4-yl)-[1,4′- bipiperidin]-4-yl)piperazin-1-yl)ethanol

 

411

3-((4-(dodecyloxy)-3- fluorophenyl)sulfonyl)-4-(4-(4- ethylpiperazin-1-yl)-[1,4′-bipiperidin]-1′- yl)-6-(methylsulfinyl)quinoline

 

412

3-((4-(dodecyloxy)-3- fluorophenyl)sulfonyl)-4-(4-(4- isopropylpipeiazin-1-yl)-[1,4′- bipiperidin]-1′-yl)-6- (methylsulfinyl)quinoline

 

413

3-((4-(dodecyloxy)-3- fluorophenyl)sulfonyl)-4-(4-(4-(1- ethylpiperidin-4-yl)piperazin-1- yl)piperidin-1-yl)-6- (methylsulfinyl)quinoline

 

414

4-(4-(4-ethylpiperazin-1-yl)-[1,4′- bipiperidin]-1′-yl)-3-((3-fluoro-4- (hexadecyloxy)phenyl)sulfonyl)-6- (methylsulfinyl)quinoline

 

415

3-((3-fluoro-4- (hexadecyloxy)phenyl)sulfonyl)-4-(4-(4- isopropylpiperazin-1-yl)-[1,4′- bipiperidin]-1′-yl)-6- (methylsulfinyl)quinoline

 

416

4-(4-(4-(1-ethylpiperidin-4-yl)piperazin- 1-yl)piperidin-1-yl)-3-((3-fluoro-4- (hexadecyloxy)phenyl)sulfonyl)-6- (methylsulfinyl)quinoline

 

417

3-((4-(dodecyloxy)-2,3- difluorophenyl)sulfonyl)-4-(4-(4- methylpiperazin-1-yl)-[1,4′-bipiperidin]- 1′-yl)-6-(methylsulfinyl)quinoline

 

418

3-((4-(dodecyloxy)-2,3- difluorophenyl)sulfonyl)-4-(4-(4- ethylpiperazin-1-yl)-[1,4′-bipiperidin]-1′- yl)-6-(methylsulfinyl)quinoline

 

419

3-((4-(dodecyloxy)-2,3- difluorophenyl)sulfonyl)-4-(4-(4- isopropylpiperazin-1-yl)-[1,4′- bipiperidin]-1′-yl)-6- (methylsulfinyl)quinoline

 

420

3-((4-(dodecyloxy)-2,3- difluorophenyl)sulfonyl)-4-(4-(4-(1- ethylpiperidin-4-yl)piperazin-1- yl)piperidin-1-yl)-6- (methylsulfinyl)quinoline

 

421

3-((2,3-difluoro-4- (tetradecyloxy)phenyl)sulfonyl)-4-(4-(4- ethylpiperazin-1-yl)-[1,4′-bipiperidin]-1′- yl)-6-(methylsulfinyl)quinoline

 

422

3-((2,3-difluoro-4- (tetradecyloxy)phenyl)sulfonyl)-4-(4-(4- isopropylpiperazin-1-yl)-[1,4′- bipiperidin]-1′-yl)-6- (methylsulfinyl)quinoline

 

423

3-((2,3-difluoro-4- (tetradecyloxy)phenyl)sulfonyl)-4-(4-(4- (1-ethylpiperidin-4-yl)piperazin-1- yl)piperidin-1-yl)-6- (methylsulfinyl)quinoline

 

424

3-((2,3-difluoro-4- (hexadecyloxy)phenyl)sulfonyl)-4-(4-(4- methylpiperazin-1-yl)-[1,4′-bipiperidin]- 1′-yl)-6-(methylsulfinyl)quinoline

 

425

3-((2,3-difluoro-4- (hexadecyloxy)phenyl)sulfonyl)-4-(4-(4- ethylpiperazin-1-yl)-[1,4′-bipiperidin]-1′- yl)-6-(methylsulfinyl)quinoline

 

426

3-((2,3-difluoro-4- (hexadecyloxy)phenyl)sulfonyl)-4-(4-(4- isopropylpiperazin-1-yl)-[1,4′- bipiperidin]-1yl)-6- (methylsulfinyl)quinoline

 

427

3-((2,3-difluoro-4- (hexadecyloxy)phenyl)sulfonyl)-4-(4-(4- (1-ethylpipendin-4-yl)piperazin-1- yl)piperidin-1-yl)-6- (methylsulfinyl)quinoline

 

428

3-((4-(dodecyloxy)-3,5- difluorophenyl)sulfonyl)-4-(4-(4- methylpiperazn-1-yl)-[1,4′-bipiperidin]- 1′-yl)-6-(methylsulfinyl)quinoline

 

429

3-((4-(dodecyloxy)-3,5- difluorophenyl)sulfonyl)-4-(4-(4- ethylpiperazin-1-yl)-[1,4′-bipiperidin]-1′- yl)-6-(methylsulfinyl)quinoline

 

430

3-((4-(dodecyloxy)-3,5- difluorophenyl)sulfonyl)-4-(4-(4- isopropylpiperazin-1-yl)-[1,4′- bipiperidin]-1′-yl)-6- (methylsulfinyl)quinoline

 

431

3-((4-(dodecyloxy)-3,5- difluorophenyl)sulfonyl)-4-(4-(4-(1- ethylpiperidin-4-yl)piperazin-1- yl)piperidin-1-yl)-6- (methylsulfinyl)quinoline

 

432

3-((3,5-difluoro-4- (tetradecyloxy)phenyl)sulfonyl)-4-(4-(4- ethylpiperazn-1-yl-[1,4′-bipiperidin]-1′- yl)-6-(methylsulfinyl)quinoline

 

433

3-((3,5-difluoro-4- (tetradecyloxy)phenyl)sulfonyl)-4-(4-(4- isopropylpiperazin-1-yl)-[1,4′- bipiperidin]-1′-yl)-6- (methylsulfinyl)quinoline

 

434

3-((3,5-difluoro-4- (tetradecyloxy)phenyl)sulfonyl)-4-(4-(4- (1-ethylpiperidin-4-yl)pipeiaxip-1- yl)piperidin-1-yl)-6- (methylsulfinyl)quinoline

 

435

3-((3,5-difluoro-4- (hexadecyloxy)phenyl)sulfonyl)-4-(4-(4- methylpiperazin-1-yl)-[1,4′-bipiperidin]- 1′-yl)-6-(methylsulfinyl)quinoline

 

436

3-((3,5-difluoro-4- (hexadecyloxy)phenyl)sulfonyl)-4-(4-(4- ethylpiperazin-1-yl)-[1,4′-bipiperidin]-1′- yl)-6-(methylsulfinyl)quinoline

 

437

3-((3,5-difluoro-4- (hexadecyloxy)phenyl)sulfonyl)-4-(4-(4- isopropylpiperazin-1-yl)-[1,4′- bipiperidin]-1′-yl)-6- (methylsulfinyl)quinoline

 

438

3-((3,5-difluoro-4- (hexadecyloxy)phenyl)sulfonyl)-4-(4-(4- (1-ethylpiperidin-4-yl)piperazin-1- yl)piperidin-1-yl)-6- (methylsulfinyl)quinoline

 

439

3-((4-(dodecyloxy)-2- fluorophenyl)sulfonyl)-4-(4-(4- methylpiperazin-1-yl)-[1,4′-bipiperidin]- 1′-yl)-6-(methylsulfinyl)quinoline

 

440

3-((4-(dodecyloxy)-2- fluorophenyl)sulfonyl)-4-(4-(4- ethylpiperazin-1-yl)-[1,4′-bipiperidin]-1′- yl)-6-(methylsulfinyl)quinoline

 

441

3-((4-(dodecyloxy)-2- fluorophenyl)sulfonyl)-4-(4-(4- isopropylpiperazin-1-yl)-[1,4′- bipiperidin]-1′-yl)-6- (methylsulfinyl)quinoline

 

442

3-((4-(dodecyloxy)-2- fluorophenyl)sulfonyl)-4-(4-(4-(1- ethylpiperidin-4-yl)piperazin-1- yl)piperidin-1-yl)-6- (methylsulfinyl)quinoline

 

443

4-(4-(4-ethylpiperazin-1-yl)-[1,4′- bipiperidin]-1′-yl)-3-((2-fluoro-4- (tetradecyloxy)phenyl)sulfonyl)-6- (methylsulfinyl)quinoline

 

444

3-((2-fluoro-4- (tetradecyloxy)phenyl)sulfonyl)-4-(4-(4- isopropylpiperazin-1-yl)-[1,4′- bipiperidin]-1′-yl)-6- (methylsulfinyl)quinoline

 

445

4-(4-(4-(1-ethylpiperidin-4-yl)piperazin- 1-yl)piperidin-1-yl)-3-((2-fluoro-4- (tetradecyloxy)phenyl)sulfonyl)-6- methylsulfinyl)quinoline

 

446

3-((2-fluoro-4- (hexadecyloxy)phenyl)sulfonyl-4-(4-(4- methylpiperazin-1-yl)-[1,4′-bipiperidin]- 1′-yl)-6-(methylsulfinyl)quinoline

 

447

4-(4-(4-ethylpiperazin-1-yl)-[1,4′- bipiperidin]-1′-yl)-3-((2-fluoro-4- (hexadecyloxy)phenyl)sulfonyl)-6- (methylsulfinyl)quinoline

 

448

3-((2-fluoro-4- (hexadecyloxy)phenyl)sulfonyl)-4-(4-(4- isopropylpiperazin-1-yl)-[1,4′- bipiperidin]-1′-yl)-6- (methylsulfinyl)quinoline

 

449

4-(4-(4-(1-ethylpiperidin-4-yl)piperazn- 1-yl)piperidin-1-yl)-3-((2-fluoro-4- (hexadecyloxy)phenyl)sulfonyl)-6- (methylsulfinyl)quinoline

 

450

4-([1,4′:1′,4″-terpiperidin]-1″-yl)-3-((4- (dodecyloxy)-2,3- difluorophenyl)sulfonyl-6- (methylsulfinyl)quinoline

 

451

3-((4-(dodecyloxy)phenyl)sulfonyl)-4-(4- (4-ethylpiperazin-1-yl)-[1,4′-bipiperidin]- 1′-yl)-6-(methylsulfinyl)quinoline

 

452

3-((4-(dodecyloxy)phenyl)sulfonyl)-4-(4- (4-isopropylpiperazin-1-yl)-[1,4′- bipiperidin]-1′-yl)-6- (methylsulfinyl)quinoline

 

453

4-(4-(4-ethylpiperazin-1-yl)-[1,4′- bipiperidin]-1′-yl)-6-(methylsulfinyl)-3- ((4- (tetradecyloxy)phenyl)sulfonyl)quinoline

 

454

4-(4-(4-isopropylpiperazin-1-yl)-[1,4′- bipiperidin]-1′-yl)-6-(methylsulfinyl)-3- ((4- (tetradecyloxy)phenyl)sulfonyl)quinoline

 

455

(R)-4-(4-(4-methylpiperazn-1-yl)-[1,4′- bipiperidin]-1′-yl)-6-(methylsulfinyl)-3- ((4- (octadecyloxy)phenyl)sulfonyl)quinoline

 

456

(S)-4-(4-(4-methylpiperazin-1-yl)-[1,4′- bipiperidin]-1′-yl)-6-(methylsulfinyl)-3- ((4- (octadecyloxy)phenyl)sulfonyl)quinoline

 

457

(R)-4-(4-(4-ethylpiperazin-1-yl)-[1,4′- bipiperidin]-1′-yl)-6-(methylsulfinyl)-3- ((4- (octadecyloxy)phenyl)sulfonyl)quinoline

 

458

(S)-4-(4-(4-ethylpiperazn-1-yl)-[1,4′- bipiperidin]-1′-yl)-6-(methylsulfinyl)-3- ((4- (octadecyloxy)phenyl)sulfonyl)quinoline

 

459

(R)-4-(4-(4-cyclopropylpiperazin-1-yl)- [1,4′-bipiperidin]-1′-yl)-6- (methylsulfinyl)-3-((4- (octadecyloxy)phenyl)sulfonyl)quinoline

 

460

(S)-4-(4-(4-cyclopropylpiperazin-1-yl)- [1,4′-bipiperidin]-1′-yl)-6- (methylsulfinyl)-3-((4- (octadecyloxy)phenyl)sulfonyl)quinoline

 

461

3-((4-(icosyloxy)phenyl)sulfonyl)-4-(4- (4-methylpiperazin-1-yl)-[1,4′- bipiperidin]-1′-yl)-6- (methylsulfinyl)quinoline

 

462

4-(4-(4-ethylpiperazin-1-yl)-[1,4′- bipiperidin]-1′-yl)-3-((4- (icosyloxy)phenyl)sulfonyl)-6- (methylsulfinyl)quinoline

 

463

(R)-4-(4-(4-ethylpiperazin-1-yl)-[1,4′- bipiperidin]-1′-yl)-3-((4- (icosyloxy)phenyl)sulfonyl)-6- (methylsulfinyl)quinoline

 

464

(S)-4-(4-(4-ethylpiperazin-1-yl)-[1,4′- bipiperidin]-1′-yl)-3-((4- (icosyloxy)phenyl)sulfonyl)-6- (methylsulfinyl)quinoline

 

465

3-((4-(docosyloxy)phenyl)sulfonyl)-4-(4- (4-methylpiperazin-1-yl)-[1,4′- bipiperidin]-1′-yl)-6- (methylsulfinyl)quinoline

 

466

3-((4-(docosyloxy)phenyl)sulfonyl)-4-(4- (4-ethylpiperazn-1-yl)-[1,4′-bipiperidin]- 1′-yl)-6-(methylsulfinyl)quinoline

 

467

(R)-3-((4-(docosyloxy)phenyl)sulfonyl)- 4-(4-(4-ethylpiperazin-1-yl)-[1,4′- bipiperidin]-1′-yl)-6- (methylsulfinyl)quinoline

 

468

(S)-3-((4-(docosyloxy)phenyl)sulfonyl)- 4-(4-(4-ethylpiperazin-1-yl)-[1,4′- bipiperidin]-1′-yl-6- (methylsulfinyl)quinoline

 

469

(R)-3-((4-(dodecyloxy)-2,3- difluorophenyl)sulfonyl)-4-(4-(4- ethylpiperazin-1-yl-[1,4′-bipiperidin]-1′- yl)-6-(methylsulfinyl)quinoline

 

470

(S)-3-((4-(dodecyloxy)-2,3- difluorophenyl)sulfonyl)-4-(4-(4- ethylpiperazin-1-yl)-[1,4′-bipiperidin]-1′- yl)-6-(methylsulfinyl)quinoline

 

471

(R)-4-(4-(4-ethylpiperazin-1-yl)-[1,4′- bipiperidin]-1′-yl)-3-((3-fluoro-4- (tetradecyloxy)phenyl)sulfonyl)-6- (methylsulfinyl)quinoline

 

472

(S)-4-(4-(4-ethylpiperazin-1-yl-[1,4′- bipiperidin]-1′-yl-3-((3-fluoro-4- (tetradecyloxy)phenyl)sulfonyl)-6- (methylsulfinyl)quinoline

 

473

(R)-3-((4-(dodecyloxy)phenyl)sulfonyl)- 4-(4-(4-isopropylpiperazin-1-yl)-[1,4′- bipiperidin]-1′-yl)-6- (methylsulfinyl)quinoline

 

474

(S)-3-((4-(dodecyloxy)phenyl)sulfonyl)- 4-(4-(4-isopropylpiperazin-1-yl)-[1,4′- bipiperidin]-1′-yl)-6- (methylsutriny)quinoline

 

475

(R)-3-((3-fluoro-4- (hexadecyloxy)phenyl)sulfonyl)-4-(4- (4-methylpiperazin-1-yl)-[1,4′-bipiperidin]- 1′-yl)-6-(methylsulfinyl)quinoline

 

476

(S)-3-((3-fluoro-4- (hexadecyloxy)phenyl)sulfonyl)-4-(4- (4-methylpiperazin-1-yl)-[1,4′-bipiperidin]- 1′-yl)-6-(methylsulfinyl)quinoline

 

477

(R)-4-(4-(4-methylpiperazin-1-yl)-[1,4′- bipiperidin]-1′-yl)-6-(methylsulfinyl)-3- ((4- (octadecyloxy)phenyl)sulfonyl)quinoline

 

478

(S)-4-(4-(4-methylpiperazin-1-yl)-[1,4′- bipiperidin]-1′-yl)-6-(methylsulfinyl-3- ((4- (octadecyloxy)phenyl)sulfonyl)quinoline

 

479

(R)-4-([1,4′:1′,4′′-terpiperidin]-1″-yl)-3- ((4-(dodecyloxy)phenyl)sulfonyl)-6- (methylsulfinyl)quinoline

 

480

(S)-4-([1,4′:1′,4″-terpiperidin]-1″-yl)-3- ((4-(dodecyloxy)phenyl)sulfonyl)-6- (methylsulfinyl)quinoline

 

481

3-((4-(hexadecyloxy)phenyl)sulfonyl)-4- (4-(4-methylpiperazin-1-yl)-[1,4′- bipiperidin]-1′-yl)-6- (methylthio)quinoline

 

482

3-((4-(hexadecyloxy)phenyl)sulfonyl)-4- (4-(4-methylpiperazin-1-yl)-[1,4′- bipiperidin]-1′-yl)-6- (methylsulfonyl)quinoline

 

483

4-(4-(4-(1-ethylpiperidin-4-yl)piperazin- 1-yl)piperidin-1-yl)-3-((4- (icosyloxy)phenyl)sulfonyl)-6- (methylsulfinyl)quinoline

 

484

3-((4-(docosyloxy)phenyl)sulfonyl)-4-(4- (4-(1-ethylpiperidin-4-yl)piperazin-1- yl)piperidin-1-yl)-6- (methylsulfinyl)quinoline

 

485

(R)-4-(4-(4-(1-ethylpiperidin-4- yl)piperazin-1-yl)piperidin-1-yl)-3-((4- (icosyloxy)phenyl)sulfonyl)-6- (methylsulfonyl)quinoline

 

486

(S)-4-(4-(4-(1-ethylpiperidin-4- yl)piperazin-1-yl)piperidin-1-yl)-3-((4- (icosyloxy)phenyl)sulfonyl)-6- (methylsulfonyl)quinoline

 

487

(R)-3-((4-(docosyloxy)phenyl)sulfonyl)- 4-(4-(4-(1-ethylpiperidin-4-yl)piperazin- 1-yl)piperidin-1-yl)-6- (methylsulfinyl)quinoline

 

488

(S)-3-((4-(docosyloxy)phenyl)sulfonyl)- 4-(4-(4-(1-ethylpiperidin-4-yl)piperazin- 1-yl)piperidin-1-yl)-6- (methylsulfinyl)quinoline

 

489

4-(4-(4-ethylpiperazin-1-yl)-[1,4′- bipiperidin]-1′-yl)-6-(methylsulfinyl)-3- ((4- (tetracosyloxy)phenyl)sulfonyl)quinoline

 

490

4-(4-(4-(1-ethylpiperidin-4-yl)piperazin- 1-yl)piperidin-1-yl)-6-(methylsulfinyl)-3- ((4- (tetracosyloxy)phenyl)sulfonyl)quinoline

 

491

4-(4-(4-ethylpiperazin-1-yl)-[1,4′- bipiperidin]-1′-yl)-3-((4- (hexacosyloxy)phenyl)sulfonyl)-6- (methylsulfonyl)quinoline

 

492

4-(4-(4-(1-ethylpiperidin-4-yl)piperazin- 1-yl)piperidin-1-yl)-3-((4- (hexacosyloxy)phenyl)sulfonyl)-6- (methylsulfinyl)quinoline

 

493

3-((4-(icosyloxy)phenyl)sulfonyl)-6- (methylsulfinyl)-4-(4-(4-propylpiperazin- 1-yl-[1,4′-bipiperidin]-1′-yl)quinoline

 

494

4-(4-(4-butylpiperazin-1-yl)-[1,4′- bipiperidin]-1′-yl)-3-((4- (icosyloxy)phenyl)sulfonyl)-6- (methylsulfinyl)quinoline

 

495

3-((4-(docosyloxy)phenyl)sulfonyl)-6- (methylsulfinyl)-4-(4-(4-propylpiperazin- 1-yl)-[1,4′-bipiperidin]-1′-yl)quinoline

 

496

4-(4-(4-butylpiperazin-1-yl)-[1,4′- bipiperidin]-1′-yl-3-((4- (docosyloxy)phenyl)sulfonyl)-6- (methylsulfinyl)quinoline

 

497

3-((4-(hexadecyloxy)phenyl)sulfonyl)-4- (4-(4-methylpiperazin-1-yl)-[1,4′- bipiperidin]-1′-yl)-6- (methylthio)quinoline

 

498

3-((4-(hexadecyloxy)phenyl)sulfonyl)-4- (4-(4-methylpiperazin-1-yl)-[1,4′- bipiperidin]-1′-yl)-6- (methylsulfonyl)quinoline

 

499

4-(4-(4-(1-ethylpiperidin-4-yl)piperazn- 1-yl)piperidin-1-yl)-3-((4- (hexadecyloxy)phenyl)sulfonyl)-6- (methylthio)quinoline

 

500

4-(4-(4-(1-ethylpiperidin-4-yl)piperazin- 1-yl)piperidin-1-yl)-3-((4- (hexadecyloxy)phenyl)sulfonyl)-6- (methylsulfinyl)quinoline

 

501

4-(4-(4-(1-ethylpiperidin-4-yl)piperazin- 1-yl)piperidin-1-yl)-3- ((4-(hexadecyloxy)phenyl)sulfonyl)-6- methoxyquinoline

 

502

4-(4-(4-(1-ethylpiperidin-4-yl)piperazin- 1-yl)piperidin-1-yl)-3- ((4-(hexadecyloxy)phenyl)sulfonyl)-6- (trifluoromethoxy)quinoline

 

503

4-(4-(4-(1-ethylolneridin-4-yl)piperazin- 1-yl)piperidin-1-yl)-3-((3-fluoro-4- (hexadecyloxy)phenyl)sulfonyl)-6- (methylthio)quinoline

 

504

4-(4-(4-(1-ethylpiperidin-4-yl)piperazin- 1-yl)piperidin-1-yl)-3-((3-fluoro-4- (hexadecyloxy)phenyl)sulfonyl)-6- (methylsulfinyl)quinoline

 

505

4-(4-(4-(1-ethylpiperidin-4-yl)piperazin- 1-yl)piperidin-1-yl)-3-((3-fluoro-4- (hexadecyloxy)phenyl)sulfonyl)-6- methoxyquinoline

 

506

4-(4-(4-(1-ethylpiperidin-4-yl)piperazin- 1-yl)piperidin-1-yl)-3-((3-fluoro-4- (hexadecyloxy)phenyl)sulfonyl)-6- (trifluoromethoxy)quinoline

 

507

4-(4-(4-(1-ethylpiperidin-4-yl)piperazin- 1-yl)piperidin-1-yl)-6-(methylthio)-3- ((4-(octadecyloxy)phenyl)sulfonyl)quinoline

 

508

4-(4-(4-(1-ethylpiperidin-4-yl)piperazin- 1-yl)piperidin-1-yl)-6-(methylsulfinyl)-3- ((4- (octadecyloxy)phenyl)sulfonyl)quinoline

 

509

4-(4-(4-(1-ethylolneridin-4-yl)piperazin- 1-yl)piperidin-1-yl)-6-methoxy-3-((4- (octadecyloxy)phenyl)sulfonyl)quinoline

 

510

4-(4-(4-(1-ethylpiperidin-4-yl)piperazin- 1-yl)piperidin-1-yl)-3-((4- (octadecyloxy)phenyl)sulfonyl)-6- (trifluoromethoxy)quinoline

 

511

4-(4-(4-(1-ethylpiperidin-4-yl)piperazin- 1-yl)piperidin-1-yl)-3-((3-fluoro-4- (octadecyloxy)phenyl)sulfonyl)-6- methylthio)quinoline

 

512

4-(4-(4-(1-ethylolneridin-4-yl)piperazin- 1-yl)piperidin-1-yl)-3-((3-fluoro-4- (octadecyloxy)phenyl)sulfonyl)-6- (methylsulfinyl)quinoline

 

513

4-(4-(4-(1-ethylpiperidin-4-yl)piperazin- 1-yl)piperidin-1-yl)-3-((3-fluoro-4- (octadecyloxy)phenyl)sulfonyl)-6- methoxyquinoline

 

514

4-(4-(4-(1-ethylpiperidin-4-yl)piperazin- 1-yl)piperidin-1-yl)-3-((3-fluoro-4- (octadecyloxy)phenyl)sulfonyl)-6- methoxyquinoline

 

515

4-(4-(4-(1-ethylpiperidin-4-yl)piperazin- 1-yl)piperidin-1-yl)-3-((4- (icosyloxy)phenyl)sulfonyl)-6- (methylthio)quinoline

 

516

4-(4-(4-(1-ethylpiperidin-4-yl)piperazin- 1-yl)piperidin-1-yl)-3-((4- (icosyloxy)phenyl)sulfonyl)-6- (methylsulfiny)quinoline

 

517

4-(4-(4-(1-ethylpiperidin-4-yl)piperazin- 1-yl)piperidin-1-yl)-3-((4- (icosyloxy)phenyl)sulfonyl)-6- methoxyquinoline

 

518

4-(4-(4-(1-ethylpiperidin-4-yl)piperazin- 1-yl)piperidin-1-yl)-3-((4- (icosyloxy)phenyl)sulfonyl)-6- (trifluoromethoxy)quinoline

 

519

4-(4-(4-(1-ethylpiperidin-4-yl)piperazin- 1-yl)piperidin-1-yl)-3-((3-fluoro-4- (icosyloxy)phenyl)sulfonyl-6- (methylthio)quinoline

 

520

4-(4-(4-(1-ethylpiperidin-4-yl)piperazin- 1-yl)piperidin-1-yl)-3-((3-fluoro-4- (icosyloxy)phenyl)sulfonyl)-6- (methylsulfinyl)quinoline

 

521

4-(4-(4-(1-ethylolneridin-4-yl)piperazin- 1-yl)piperidin-1-yl)-3-((3-fluoro-4- (icosyloxy)phenyl)sulfonyl)-6- methoxyquinoline

 

522

4-(4-(4-(I-ethylpiperidin-4-yl)piperazin- 1-yl)piperidin-1-yl)-3-((3-fluoro-4- (icosyloxy)phenyl)sulfonyl)-6- (trifluoromethoxy)quinoline

 

523

3-((4-(docosyloxy)phenyl)sulfonyl)-4-(4- (4-(1-ethylpiperidin-4-yl)piperazin-1- yl)piperidin-1-yl)-6- (methylthio)quinoline

 

524

3-((4-(docosyloxy)phenyl)sulfonyl)-4-(4- (4-(1-ethylpiperidin-4-yl)piperazin-1- yl)piperidin-1-yl)-6- (methylsulfonyl)quinoline

 

525

3-((4-(docosyloxy)phenyl)sulfonyl-4-(4- (4-(1-ethylpiperidin-4-yl)piperazin-1- yl)piperidin-1-yl)-6-methoxyquinoline

 

526

3-((4-(docosyloxy)phenyl)sulfonyl)-4-(4- (4-(1-ethylpiperidin-4-yl)piperazin-1- yl)piperidin-1-yl)-6- (trifluoromethoxy)quinoline

 

527

3-((4-(docosyloxy)-3- fluorophenyl)sulfonyl)-4-(4-(4-(1- ethylpiperidin-4-yl)piperazin-1- yl)piperidin-1-yl)-6- (methylthio)quinoline

 

528

3-((4-(docosyloxy)-3- fluorophenyl)sulfonyl-4-(4-(4-(1- ethylpiperidin-4-yl)piperazin-1- yl)piperidin-1-yl)-6- (methylsulfinyl)quinoline

 

529

3-((4-(docosyloxy)-3- fluorophenyl)sulfonyl-4-(4-(4-(1- ethylpiperidin-4-yl)piperazin-1- yl)piperidin-1-yl)-6-methoxyquinoline

 

530

3-((4-(docosyloxy)-3- fluorophenyl)sulfonyl)-4-(4-(4-(1- ethylpiperidin-4-yl)piperazin-1- yl)piperidin-1-yl)-6- (trifluoromethoxy)quinoline

 

531

3-((4-(docosyloxy)-3,5- difluorophenyl)sulfonyl)-4-(4-(4-(1- ethylpiperidin-4-yl)piperazin-1- yl)piperidin-1-yl)-6- (trifluoromethoxy)quinoline

 

532

3-((4-(docosyloxy)-2,3- difluorophenyl)sulfonyl)-4-(4-(4-(1- ethylpiperidin-4-yl)piperazin-1- yl)piperidin-1-yl)-6- (trifluoromethoxy)quinoline

 

533

3-((4-(docosyloxy)-2- fluorophenyl)sulfonyl)-4-(4-(4-(1- ethylpiperidin-4-yl)piperazin-1- yl)piperidin-1-yl)-6- (trifluoromethoxy)quinoline

 

534

3-((3,5-difluoro-4- (icosyloxy)phenyl)sulfonyl)-4-(4-(4-(1- ethylpiperidin-4-yl)piperazin-1- yl)piperidin-1-yl)-6- (trifluoromethoxy)quinoline

 

535

3-((2,3-difluoro-4- (icosyloxy)phenyl)sulfonyl)-4-(4-(4-(1- ethylpiperidin-4-yl)piperazin-1- yl)piperidin-1-yl)-6- (trifluoromethoxy)quinoline

 

536

4-(4-(4-(1-ethylpiperidin-4-yl)piperazin- 1-yl)piperidin-1-yl)-3-((2-fluoro-4- (icosyloxy)phenyl)sulfonyl)-6- (trifluoromethoxy)quinoline

 

537

3-((3,5-difluoro-4- (octadecyloxy)phenyl)sulfonyl)-4-(4-(4- (1-ethylpiperidin-4-yl)piperazin-1- yl)piperidin-1-yl)-6- (trifluoromethoxy)quinoline

 

538

3-((2,3-difluoro-4- (octadecyloxy)phenyl)sulfonyl)-4-(4-(4- (1-ethylpiperidin-4-yl)piperazin-1- yl)piperidin-1-yl)-6- (trifluoromethoxy)quinoline

 

539

4-(4-(4-(1-ethylpiperidin-4-yl)piperazin- 1-yl)piperidin-1-yl)-3-((2-fluoro-4- (octadecyloxy)phenyl)sulfonyl)-6- (trifluoromethoxy)quinoline

 

540

3-((3,5-difluoro-4- (hexadecyloxy)phenyl)sulfonyl)-4-(4-(4- (1-ethylpiperidin-4-yl)piperazin-1- yl)piperidin-1-yl)-6- (trifluoromethoxy)quinoline

 

541

3-((2,3-difluoro-4- (hexadecyloxy)phenyl)sulfonyl)-4-(4-(4- (1-ethylpiperidin-4-yl)piperazin-1- yl)piperidin-1-yl)-6- (trifluoromethoxy)quinoline

 

542

4-(4-(4-(1-ethylpiperidin-4-yl)piperazin- 1-yl)piperidin-1-yl)-3-((2-fluoro-4- (hexadecyloxy)phenyl)sulfonyl)-6- (trifluoromethoxy)quinoline

 

543

3-((2,6-difluoro-4- (hexadecyloxy)phenyl)sulfonyl)-4-(4-(4- (1-ethylpiperidin-4-yl)piperazin-1- yl)piperidin-1-yl)-6- (trifluoromethoxy)quinoline

 

544

3-((2,6-difluoro-4- (octadecyloxy)phenyl)sulfonyl)-4-(4-(4- (1-ethylpiperidin-4-yl)piperazin-1- yl)piperidin-1-yl)-6- (trifluoromethoxy)quinoline

 

545

3-(42,6-difluoro-4- (icosyloxy)phenyl)sulfonyl)-4-(4-(4-(1- ethylpiperidin-4-yl)piperazin-1- yl)piperidin-1-yl)-6- (trifluoromethoxy)quinoline

 

546

3-((4-(docosyloxy)-2,6- difluorophenyl)sulfonyl)-4-(4-(4-(1- ethylpiperidin-4-yl)piperazin-1- yl)piperidin-1-yl)-6- (trifluoromethoxy)quinoline

 

547

3-((2,5-difluoro-4- (hexadecyloxy)phenyl)sulfonyl)-4-(4-(4- (1-ethylpiperidin-4-yl)piperazin-1- yl)piperidin-1-yl)-6- (trifluoromethoxy)quinoline

 

548

3-((2,5-difluoro-4- (octadecyloxy)phenyl)sulfonyl)-4-(4-(4- (1-ethylpiperidin-4-yl)piperazin-1- yl)piperidin-1-yl)-6- (trifluoromethoxy)quinoline

 

549

3-((2,5-difluoro-4- (icosyloxy)phenyl)sulfonyl-4-(4-(4-(1- ethylpiperidin-4-yl)piperazin-1- yl)piperidin-1-yl)-6- (trifluoromethoxy)quinoline  and

 

550

3-((4-(docosyloxy)-2,5- difluorophenyl)sulfonyl)-4-(4-(4-(1- ethylpiperidin-4-yl)piperazin-1- yl)piperidin-1-yl)-6- (trifluoromethoxy)quinoline, or a pharmaceutically acceptable salt, isotopically enriched analog, stereoisomer, mixture of stereoisomers, or tautomer thereof.