Patent ID: 11938188
Assignee: THE GENERAL HOSPITAL CORPORATION
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 17:
18. A slurry configured for injection into a target tissue comprising:
a plurality of sterile ice particles having a largest cross-sectional dimension less than about 1.5 mm;
a biocompatible surfactant, wherein the biocompatible surfactant is glycerol; and
a foam comprising a plurality of gas bubbles;
wherein the slurry is configured to cause the target tissue to reach a temperature in the range of about −8° C. to about 0° C. such that crystallization occurs in the target tissue and the crystallization causes localized and selective damage to the target tissue;
wherein:
the target tissue comprises adipose tissue; or
the target tissue comprises a target nerve and the crystallization occurs in a myelin sheath of the target nerve and causes localized and selective damage to said target nerve.