Patent ID: 11872264
Assignee: CHONDROPEPTIX BV
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 0:
1. A method for the treatment or amelioration of osteoarthritis, the method comprising:
administering to a subject in need thereof a therapeutic amount of a peptide;
wherein the peptide is between 12 and 28 amino acids in length and comprises the full length of the amino acid sequence according to SEQ ID NO: 16 or comprises the full length of a variant of SEQ ID NO: 16 according to formula 2,
wherein the amino acid sequence of the peptide is comprised in SEQ ID NO: 34 or a variant thereof according to formula 1,
wherein formula 1 is:, (SEQ ID NO: 47)

X1 X2 X3 G Y X4 A X5 Y S E G X6 S X7 X8 X9 L

X10 X11 X12 M N A T X13 H A

wherein
X1=A or I or L or M or Y or V or E or H or K or Q or R,
X2=P or Y or M,
X3=E or R or H or K or N or P or Q or S or T or I or L or M or V,
X4=A or E or Q or R or S,
X5=Y or N or D,
X6=E or A or Q,
X7=A or D or E or H or K or S,
X8=F or A or D or E or H or Q or R or S,
X9=P or M,
X10=N or A or D or S or T or E or Q or R or I or V,
X11=S or A or D or E or H or K or N or P or Q or T,
X12=Y or D or G or H or N or R or S or T, and
X13=N or F or W or Y or H or K or R; and
wherein Formula 2 is:, (SEQ ID NO: 48)

Y S E G X6 S X7 X8 X9 L X10 X11

wherein
X6=E or A or Q,
X7=A or D or E or H or K or S,
X8=F or A or D or E or H or Q or R or S,
X9=P or M,
X10=N or A or D or S or T or E or Q or R or I or V, and
X11=S or A or D or E or H or K or N or P or Q or T.