Patent ID: 11897917
Assignee: UNIVERSITY OF YORK
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C  B | IPC B  C

Claim 14:
15. The method according to claim 1, which comprises, prior to step (a), contacting a polypeptide with an oxidising reagent to generate the first aldehyde moiety on the polypeptide and form the first polypeptide, wherein:
(i) the oxidising reagent is periodate and wherein the method comprises oxidising a N-terminal serine residue or a N-terminal threonine residue to form an alpha-oxy aldehyde moiety, or
(ii) the oxidising reagent is pyridoxal-5-phosphate (PLP) and the method comprises oxidising a N-terminal lysine residue to form an alpha-oxy aldehyde moiety.