Patent ID: 11925470
Assignee: CARNEGIE MELLON UNIVERSITY
Field: Medical technology (Instruments)
Classification: CPC A | IPC A

Claim 0:
1. A method for localizing regions of silence in a brain cortex comprising: collecting signals having a power component from a plurality of EEG electrodes; identifying one or more spatially-uncorrelated sources of the collected EEG signals; detecting and localizing one or more regions of silence in a low-resolution spatial grid of the brain by accounting for a contribution of each of the sources to the power component of the collected EEG signals; using the low-resolution grid as an input to a high resolution spatial grid of the brain, wherein the one or more localized regions of silence in the low-resolution grid are used as an initial estimate of locations of the one or more regions of silence in the high-resolution grid; and iteratively localizing the one or more regions of silence in the high-resolution grid based on a covariance of the sources and a contribution of each of the sources to the power component of the collected EEG signals until a center-of-mass for each region of silence converges; wherein localizing the one or more regions of silence in a low-resolution grid further comprises: indicating locations of the sources in a model brain; determining, for each source, a cross-correlation coefficient indicating the contribution of the source to readings from each of the plurality of electrodes; calculating a normalized variance for each of the cross-correlation coefficients; deriving, based on the normalized variance, a source contribution measure for the low-resolution grid for each of the sources; and localizing silent sources in the low-resolution grid using convex spectral clustering based on the source contribution measures for the low-resolution grid; wherein the low-resolution grid is a coarse discretization of the brain cortex in which the spatially-uncorrelated sources are localized; and wherein the high-resolution grid is a fine discretization of the brain cortex in which the sources are correlated.