Patent ID: 11866686
Assignee: HOFFMANN-LA ROCHE, INC.
Field: Measurement (Instruments)
Classification: CPC C  G | IPC C  G

Claim 16:
17. The system of claim 13, further configured to:
receive a third CO2 concentration and a third pH value, the third CO2 concentration being a CO2 concentration of a third gas volume above the medium in the first tank, the third CO2 concentration and the third pH value being measured at a third time, the third time being a time when the medium in the first tank is in pH-CO2 equilibrium state at the predefined temperature and pressure with the third gas volume and after said equilibrium state is modified by the metabolism of a cell culture in the first tank, the third pH value being a measured value provided by the first pH measuring device;
receive a fourth CO2 concentration and a fourth pH value, the fourth CO2 concentration being a CO2 concentration of a fourth gas volume above the medium in the second tank, the fourth CO2 concentration and the fourth pH value being measured at a fourth time, the fourth time being a time when the medium in the second tank is in pH-CO2 equilibrium state at the predefined temperature and pressure with the second gas volume and after said equilibrium state is modified by the metabolism of the cell culture in the second tank, the fourth pH value being a measured value provided by the second pH measuring device, a lapsed time between the third time and inoculation of the first tank being identical to a lapsed time between the fourth time and inoculation of the second tank;
receive a measured first oxygen uptake rate of the cell culture in the first tank at the third time;
receive a measured second oxygen uptake rate of the cell culture in the second tank at the fourth time;
in case the first and second oxygen uptake rates are identical, compare the third and fourth pH values and CO2 concentrations for determining if the first and second pH measuring devices are calibrated differently.