Patent ID: 11970532
Assignee: NEURACLE SCIENCE CO., LTD.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 6:
7. The anti-FAM19A5 antibody of claim 1, which exhibits one or more of the following properties:
(a) binds to soluble human FAM19A5 with a KD of 10 nM or less as measured by enzyme-linked immunosorbent assay (ELISA);
(b) binds to membrane bound human FAM19A5 with a KD of 10 nM or less as measured by ELISA;
(c) reduces, reverses, and/or delays an onset of reactive gliosis;
(d) suppresses an excessive proliferation of reactive astrocytes;
(e) decreases expression of chondroitin sulfate proteoglycans;
(f) increases expression of c-fos and pERK in the nucleus of neurons;
(g) promotes survival of neurons;
(h) increases expression of GAP43 in neurons;
(i) promotes regrowth of an axon;
(j) induces normalization of blood vessels;
(k) suppresses growth of a tumor;
(l) enhances infiltration of immune cells into a tumor;
(m) enhances infiltration of neuronal cells into a tumor;
(n) enhances phagocytic activity of a macrophage or a microglia;
(o) increases a mitochondrial membrane potential of a macrophage or a microglia;
(p) reduces recruitment of myeloid-derive suppressor cells (MDSCs) to a tumor;
(q) reduces necrosis and edema in a tumor;
(r) reduces tissue permeability of a tumor;
(s) increases a blood flow rate in a tumor;
(t) cross-competes with the reference antibody for binding to a FAM19A5 protein; or
(u) any combination thereof 21.