Patent ID: 11857528
Assignee: AXSOME MALTA LTD.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 12:
13. A method of treating excessive daytime sleepiness in a subject in need thereof having mild, moderate, or severe renal impairment, said method comprising:
(a) providing to the subject having an eGFR of about 30 mL/min/1.73 m2 to about 59 mL/min/1.73 m2 an oral daily dose of [R]-2-amino-3-phenylpropylcarbamate (APC) that does not produce an AUC∞, for APC greater than 2.3 times the AUC∞ for a subject without renal impairment;
(b) providing to the subject having an eGFR of about 15 mL/min/1.73 m2 to about 29 mL/min/1.73 m2 an oral dose of APC that does not produce an AUC∞ greater than 4.4 times the AUC∞ for a subject without renal impairment; or
(c) providing to the subject having an eGFR of about 60 mL/min/1.73 m2 to about 89 mL/min/1.73 m2 an oral daily dose of APC that does not produce an AUC∞ greater than 1.5 times the AUC∞ for a subject without renal impairment.