Patent ID: 11939365
Assignee: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A  G | IPC A  C  G

Claim 0:
1. An isolated or purified T cell receptor (TCR) having antigenic specificity for mutated human p53, wherein the mutated human p53 has one of the following human p53 mutations: R175H, Y220C, G245S, R248Q, or R248W, wherein the human p53 mutations are defined by reference to SEQ ID NO: 1, and wherein the TCR comprises an amino acid sequence at least 97% identical to SEQ ID NO: 23 or 24, an amino acid sequence at least 97% identical to SEQ ID NO: 25, and the amino acid sequences of:
(1) all of SEQ ID NOs: 27-32;
(2) all of SEQ ID NOs: 37-42;
(3) all of SEQ ID NOs: 47-52;
(4) all of SEQ ID NOs: 57-62;
(5) all of SEQ ID NOs: 67-72;
(6) all of SEQ ID NOs: 77-82;
(7) all of SEQ ID NOs: 87-92;
(8) all of SEQ ID NOs: 97-102;
(9) all of SEQ ID NOs: 107-112;
(10) all of SEQ ID NOs: 117-122;
(11) all of SEQ ID NOs: 127-132;
(12) all of SEQ ID NOs: 137-142;
(13) all of SEQ ID NOs: 147-152;
(14) all of SEQ ID NOs: 157-162;
(15) all of SEQ ID NOs: 167-172;
(16) all of SEQ ID NOs: 177-182;
(17) all of SEQ ID NOs: 187-192;
(18) all of SEQ ID NOs: 197-202;
(19) all of SEQ ID NOs: 207-212;
(20) all of SEQ ID NOs: 217-222;
(21) all of SEQ ID NOs: 227-232;
(22) all of SEQ ID NOs: 237-242;
(23) all of SEQ ID NOs: 247-252;
(24) all of SEQ ID NOs: 257-262;
(25) all of SEQ ID NOs: 267-272;
(26) all of SEQ ID NOs: 277-282;
(27) all of SEQ ID NOs: 287-292;
(28) all of SEQ ID NOs: 297-302;
(29) all of SEQ ID NOs: 307-312;
(30) all of SEQ ID NOs: 317-322;
(31) all of SEQ ID NOs: 327-332;
(32) all of SEQ ID NOs: 337-342;
(33) all of SEQ ID NOs: 347-352;
(34) all of SEQ ID NOs: 357-362;
(35) all of SEQ ID NOs: 367-372;
(36) all of SEQ ID NOs: 377-382;
(37) all of SEQ ID NOs: 387-392;
(38) all of SEQ ID NOs: 397-402;
(39) all of SEQ ID NOs: 407-412;
(40) all of SEQ ID NOs: 417-422;
(41) all of SEQ ID NOs: 427-432;
(42) all of SEQ ID NOs: 437-442;
(43) all of SEQ ID NOs: 447-452;
(44) all of SEQ ID NOs: 457-462;
(45) all of SEQ ID NOs: 477-482; or
(46) all of SEQ ID NOs: 487-492.