Patent ID: 11938180
Assignee: SECRETARY OF STATE FOR HEALTH AND SOCIAL CARE, MINISTERIAL CORRESPONDENCE AND PUBLIC ENQUIRIES, DEPARTMENT OF HEALTH AND SOCIAL CARE
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C  Y | IPC A  C

Claim 0:
1. A poliovirus-like particle (VLP) which comprises modifications relative to the poliovirus particle from which the VLP is derived which stabilise the VLP, wherein:
(a) the VLP is derived from a type 1 poliovirus and comprises the following mutations: R4018G, T2025A, D2057E, L3119M, Q3178L and H1248P;
(b) the VLP is derived from a type 2 poliovirus and comprises the following mutations: L3085F, Q3178L, T1041I, F1134L and Y1159F;
(c) the VLP is derived from a type 2 poliovirus and comprises the following mutations: I4057V, D2057A, Q3178L, V1107I, F1134L and V1183L; or
(d) the VLP is derived from a type 3 poliovirus and comprises the following mutations: T4067A, L20181, L2215M, D2241E, H3019Y, L3085F, T1105M and F1132L;
wherein the modifications relative to the poliovirus particle from which the VLP is derived stabilises the native-antigenic conformation of the poliovirus capsid.