Patent ID: 11964026
Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 0:
1. A particle comprising:
a liposome, wherein the liposome comprises a first lipid covalently bonded to an affinity ligand; and the first lipid forms an outer surface of the liposome;
a cytokine covalently bonded to a tag, wherein the tag is associated with the affinity ligand, and wherein the cytokine binds a receptor on the surface of an immune cell when the particle contacts a cancer cell; and
a polymer coating, wherein the polymer coating comprises:
at least one layer including a polycation, wherein the polycation is non-covalently associated with the outer surface of the liposome; and
at least one layer including polyglutamic acid, wherein the polyglutamic acid is non-covalently associated with the at least one polycation layer.