Patent ID: 11970535
Assignee: INNATE PHARMA
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 11:
12. The method of claim 1, wherein the agent is an antibody that binds specifically to a KIR3DL2 polypeptide, comprising an Fc region derived from a human IgG1 isotype, characterized by an EC50 in a 51Cr-release assay for HuT78 tumor lysis by PBMC from healthy volunteers, that is (a) less than or within 1-log of the EC50 of an antibody comprising a heavy chain variable region comprising SEQ ID NO: 31, a light chain variable region comprising SEQ ID NO: 25 or 26, and an Fc region of human IgG1 isotype, and/or (b) less than 100 ng/ml, optionally between 1 and 100 ng/ml.