Patent ID: 11964007
Assignee: JANSSEN VACCINES & PREVENTION B.V.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 10:
11. A combination for inducing an immune response in a human subject, comprising:
a. a first composition comprising an immunologically effective amount of an IVT repRNA comprising a first polynucleotide encoding a first antigenic protein or an immunogenic polypeptide thereof, together with a pharmaceutically acceptable carrier, wherein the IVT repRNA is formulated into a non-virion particle, and
b. a second composition comprising an immunologically effective amount of a recombinant human adenovirus serotype 26 (Ad26) vector or a recombinant human adenovirus serotype 35 (Ad35) vector comprising a second polynucleotide encoding a second antigenic protein or an immunogenic polypeptide thereof, together with a pharmaceutically acceptable carrier,, wherein the first or second antigenic protein is derived from an Influenza virus, and wherein the first and second antigenic proteins share at least one antigenic determinant, and one of the compositions is a priming composition and the other composition is a boosting composition.