Patent ID: 11911435
Assignee: GENEQUANTUM HEALTHCARE (SUZHOU) CO., LTD.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 7:
8. A composition comprising the compound according to claim 1, which is prepared by the following steps:
i) a compound of Formula (I) or (II) is prepared:, or a pharmaceutically acceptable salt thereof, wherein
PCA is the specific recognition sequence of the ligase donor substrate or the specific recognition sequence of the ligase acceptor substrate;
LA1 and LA2 are linker moieties;
a and p are independently 0 or 1, that is, LA1 and LA2 are independently present or absent;
CCA′ is a chemical conjugation moiety;
 represents a single or double bond;
Y is a radioactive label, a fluorescent label, an affinity purification tag, a tracer molecule, an anticancer drug or a cytotoxic molecule;
z is any one of the integers between 1 and 1000,
ii) A-(LA3)b-F according to claim 1 is prepared;
iii) A-(LA3)b-F obtained in step ii) and a compound of Formula (I) or (II) obtained in step i) are conjugated at the presence of the ligase and under conditions suitable for action of the ligase.