Patent ID: 11911460
Assignee: SHANDONG WEIGAO LITONG BIOLOGICAL PRODUCTS CO., LTD.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  Y | IPC A

Claim 0:
1. A virus-like structure (VLS) vaccine, comprising a lipid nanoparticle (LNP), wherein the LNP comprises:
a first cationic lipid of ((2-(2-hydroxyethoxy)ethyl)azanediyl)bis(hexane-6,1-diyl)bis(2-hexyldecanoate) (DHA-1),
a second cationic lipid of (2,3-dioleoyl-propyl)-trimethylammonium-chloride (DOTAP),
a phospholipid of 1,2-dioleoyl-SN-glycero-3-phosphocholine (DOPC), and
a polyethylene glycol (PEG)-lipid of methoxypoly(ethylene glycol)-N-tetradecyltetradecanamide-2K (mPEG-DTA-1-2K); and wherein
the LNP encapsulates a non-self-replicating mRNA encoding a SARS-CoV-2 membrane spike (S1) protein; and wherein a surface of the LNP comprises an S1 antigen protein bound to the surface.