Patent ID: 11944676
Assignee: PEBBLE LABS INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 0:
1. A compound for the biocontrol of pathogenic bacteria comprising:
a treated feed, a solid inoculum, or a liquid inoculum for a target host infected with or susceptible to a pathogenic bacteria, said treated feed, solid inoculum, or liquid inoculum comprising a genetically modified donor bacteria that may be introduced to a target host or said target host's environment, wherein said genetically modified donor bacteria is configured to express heterologous lsr operon or aidH and wherein:
said heterologous nucleic acid comprises a nucleotide sequence according to SEQ ID NO:1 or a sequence having approximately 75% or more homology with SEQ ID NO:1 which encodes for said heterologous aidH as a quorum quenching molecule configured to remove exogenous autoinducer-1 (AI-1) molecules from the environment; or
said heterologous nucleic acid comprises a nucleotide sequence according to SEQ ID NO:2 or a sequence having approximately 75% or more homology with SEQ ID NO:2 which encodes for said heterologous lsr operon as a quorum quenching molecule configured to remove exogenous autoinducer-2 (AI-2) molecules from the environment resulting in the reduction or inhibition of quorum sensing (QS) in said pathogenic bacteria.