Patent ID: 11926628
Assignee: GILEAD SCIENCES, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 0:
1. A compound of Formula (I):, or a pharmaceutically acceptable salt thereof, wherein
Z1 is N or CR1;
Z2 is N or CR2;
Z4 is N or CR4;
Z7 is N or CR7;
Z8 is N or CR8;
Z9 is N or CR9;
each R1 and R4 is hydrogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 alkoxy, halogen, C1-6 haloalkyl, C1-6 haloalkoxy, or —CN; R1 and R4 can be the same or different;
R2 is hydrogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 hydroxyalkyl, C1-6 aminoalkyl, C1-6 alkoxy, C2-6 alkoxyalkyl, halogen, C1-6 haloalkyl, C1-6 haloalkoxy, —CN, —NO, —NO2, —C(O)R2a, —C(O)OR2a, —OC(O)R2a, —C(O)N(R2a)(R2b), —N(R2a)C(O)R2b, —OC(O)N(R2a)(R2b), —N(R2a)C(O)OR2b, —C(═NR2a)N(R2b)(R2c), —N(R2a)(R2b), —N(R2a)N(R2b)(R2c), —N(R2a)N═C(R2b)(OR2c), —OR2a, —SR2a, —S(O)R2a, —S(O)(NR2a)(R2b), —S(NR2a)(NR2b)(R2c), S(O)2R2a, —S(O)2N(R2a)(R2b), —N(R2a)S(O)2(R2b), —P(R2a)(R2b), —P(O)(R2a)(R2b), —P(O)(OR2a)(R2b), —P(O)(OR2a)(OR2b), C3-10 cycloalkyl, C1-6 alkyl-C3-10 cycloalkyl, C6-12 aryl, C1-6 alkyl-C6-12 aryl, heterocycloalkyl, C1-6 alkyl-(heterocycloalkyl), heteroaryl, or C1-6 alkyl-(heteroaryl), wherein each alkyl, alkenyl or alkynyl is independently optionally substituted with 1 to 3 R2d groups which can be the same or different, each cycloalkyl is optionally substituted with 1 to 3 R2e groups which can be the same or different, each aryl is optionally substituted with 1 to 3 R2f groups which can be the same or different, each heterocycloalkyl is optionally substituted with 1 to 3 R2g groups which can be the same or different, and each heteroaryl is optionally substituted with 1 to 3 R2h groups which can be the same or different;
each R2a, R2b, and R2e is independently hydrogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 hydroxyalkyl, C1-6 aminoalkyl, C2-6 alkoxyalkyl, C1-6 haloalkyl, C3-10 cycloalkyl, C1-6 alkyl-C3-10 cycloalkyl, C6-12 aryl, C1-6 alkyl-C6-12 aryl, heterocycloalkyl, C1-6 alkyl-(heterocycloalkyl), heteroaryl, or C1-6 alkyl-(heteroaryl), wherein the aryl or heteroaryl is optionally substituted with 1 to 3 R2j;
alternatively, R2a, R2b, and R2C when attached to the same atom can be combined with the atom to which they are attached to form a heterocycloalkyl;
each R2d is independently —CN, —C(O)R2d1, —C(O)OR2d1, —OC(O)R2d1, —C(O)N(R2d1)(R22), —N(R2d1)C(O)R2d2, —OC(O)N(R2d1)(R2d2), —N(R2d1)C(O)OR2d2, —N(R2d1)(R22), ═O, —OR2d1, —SR2d1, —S(O)R2d1, —S(O)(NR2d1)(R2d2), —S(O)2R2d1, —S(O)N(R2d1)(R2d2), —N(R2d1)S(O)2R2d2, C3-10 cycloalkyl, C1-6 alkyl-C3-10 cycloalkyl, C6-12 aryl, C1-6 alkyl-C6-12 aryl, heterocycloalkyl, C1-6 alkyl-(heterocycloalkyl), heteroaryl, or C1-6 alkyl-(heteroaryl);
each R2d1 and R2d2 is independently hydrogen, C1-6 alkyl, C1-6 hydroxyalkyl, C1-6 aminoalkyl, C2-6 alkoxyalkyl, or C1-6 haloalkyl;
each R2e, R2f, R2g, and R2h is independently hydrogen, C1-6 alkyl, C1-6 hydroxyalkyl, C1-6 aminoalkyl, C1-6 alkoxy, C2-6 alkoxyalkyl, halogen, C1-6 haloalkyl, C1-6 haloalkoxy, —CN, or —OH;
each R2j is independently C1-6 alkyl, C1-6 hydroxyalkyl, C1-6 aminoalkyl, C1-6 alkoxy, C2-6 alkoxyalkyl, halogen, C1-6 haloalkyl, or C1-6 haloalkoxy;
R3 is hydrogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 hydroxyalkyl, C1-6 aminoalkyl, C1-6 alkoxy, C2-6 alkoxyalkyl, halogen, C1-6 haloalkyl, C1-6 haloalkoxy, —CN, —NO, —NO2, —C(O)R3a, —C(O)OR3a, —OC(O)R3a, —C(O)N(R3a)(R3b), —N(R3a)C(O)R3b, —OC(O)N(R3a)(R3b), —N(R3a)C(O)OR3b, —C(═NR3a)N(R3b)(R3c), —N(R3a)(R3b), —N(R3a)N(R3b)(R3c), —N(R3a)N═C(R3b)(OR3c), —OR3a, —SR3a, —S(O)R3a, —S(O)(NR3a)(R3b), —S(NR3a)(NR3b)(R3c), —S(O)2R3a, —S(O)2N(R3a)(R3b), —N(R3a)S(O)2(R3b), —P(R3a)(R3b), —P(O)(R3a)(R3b), —P(O)(OR3a)(R3b), —P(O)(OR3a)(OR3b), C3-10 cycloalkyl, C1-6 alkyl-C3-10 cycloalkyl, C6-12 aryl, C1-6 alkyl-C6-12 aryl, heterocycloalkyl, C1-6 alkyl-(heterocycloalkyl), heteroaryl, or C1-6 alkyl-(heteroaryl), wherein each alkenyl or alkynyl is independently optionally substituted with 1 to 3 R3d groups, each cycloalkyl is optionally substituted with 1 to 3 R3e groups, each aryl is optionally substituted with 1 to 3 R3f groups which can be the same or different, each heterocycloalkyl is optionally substituted with 1 to 3 R3g groups which can be the same or different, and each heteroaryl is optionally substituted with 1 to 3 R3h groups which can be the same or different;
each R3a, R3b, and R3c is independently hydrogen, C1-6 alkyl, C1-6 hydroxyalkyl, C2-6 alkoxyalkyl, C1-6 haloalkyl, C3-10 cycloalkyl, C1-6 alkyl-C3-10 cycloalkyl, C6-12 aryl, C1-6 alkyl-C6-12 aryl, heterocycloalkyl, or heteroaryl;
alternatively, R3a, R3b, and R3c when attached to the same atom can be combined with the atom to which they are attached to form a heterocycloalkyl;
each R3d is independently —N(R3d1)(R3d2), —OR3d1, C3-10 cycloalkyl, C1-6 alkyl-C3-10 cycloalkyl, C6-12 aryl, C1-6 alkyl-C6-12 aryl, heterocycloalkyl, or heteroaryl;
each R3d1 and R3d2 is independently hydrogen, C1-6 alkyl, or —C(O)O—(C1-6 alkyl);
each R3e, R3f, R39, and R3h is independently hydrogen, C1-6 alkyl, C1-6 alkoxy, halogen, C1-6 haloalkyl or C1-6 haloalkoxy;
R5 is C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 hydroxyalkyl, C2-6 alkoxyalkyl, C1-6 haloalkyl, C3-10 cycloalkyl, C1-6 alkyl-C3-10 cycloalkyl, C6-12 aryl, C1-6 alkyl-C6-12 aryl, heterocycloalkyl, C1-6 alkyl-(heterocycloalkyl), heteroaryl, or C1-6 alkyl-(heteroaryl), wherein the alkyl is optionally substituted with R5a;
R5a is —OSi(R5a1)(R5a2)(R5a3);
R5a1, R5a2, and R5a3 are each independently C1-6 alkyl; and
R6 is C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C6-12 aryl, or heteroaryl, wherein the aryl or heteroaryl are each optionally substituted with 1 to 3 R6a; each R6a is independently C1-6 alkyl, C2-6 alkenyl, C2-8 alkynyl, C1-6 hydroxyalkyl, C1-6 aminoalkyl, C1-6 alkoxy, C2-6 alkoxyalkyl, halogen, C1-6 haloalkyl, C1-6 haloalkoxy, —CN, —NO2, —C(O)R6b, —C(O)OR6b, —OC(O)R6b, —C(O)N(R6b)(R6c), —N(R6b)C(O)R6c, —C(═NR6b)N(R6c)(R6d), —N(R6b)(R6), —OR6b, —SR6b, —S(O)R6b, —S(O)2R6b, —S(NR6b)(NR6c)R6d, —S(O)(NR6b)(R6c), —S(O)2N(R6b)(R6c), —N(R6n)S(O)2(R6e), —P(R6b)(R6c), —P(O)(R6b)(R6e), —P(O)(OR6b)(R6c), —P(O)(OR6b)(OR6c), C3-10 cycloalkyl, C1-6 alkyl-C3-10 cycloalkyl, C6-12 aryl, C1-6 alkyl-C6-12 aryl, heterocycloalkyl, C1-6 alkyl-(heterocycloalkyl), heteroaryl, or C1-6 alkyl-(heteroaryl), wherein the cycloalkyl, aryl, heterocycloalkyl, or heteroaryl is each optionally substituted with 1 to 3 R6e which can be the same or different, the alkyl is optionally substituted with R6f which can be the same or different, and the alkynyl is optionally substituted with 1 to 4 R6j which can be the same or different;
each R6b, R6c and R6d is independently hydrogen, C1-6 alkyl, C1-6 hydroxyalkyl, C1-6 aminoalkyl, C2-6 alkoxyalkyl, C1-6 haloalkyl, C3-10 cycloalkyl, C1-6 alkyl-C3-10 cycloalkyl, C6-12 aryl, C1-6 alkyl-C6-12 aryl, heterocycloalkyl, C1-6 alkyl-(heterocycloalkyl), heteroaryl, or C1-6 alkyl-(heteroaryl), wherein the cycloalkyl, aryl, heterocycloalkyl, or heteroaryl is optionally substituted by 1 to 3 R6k which can be the same or different;
each R6k is independently C1-6 alkyl, C1-6 hydroxyalkyl, C1-6 aminoalkyl, C1-6 alkoxy, C2-6 alkoxyalkyl, C1-6 haloalkyl, C1-6 haloalkoxy, C3-10 cycloalkyl, C1-6 alkyl-C3-10 cycloalkyl, heterocycloalkyl, or C1-6 alkyl-(heterocycloalkyl);
each R6e is independently C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 hydroxyalkyl, C1-6 aminoalkyl, C1-6 alkoxy, C2-6 alkoxyalkyl, halogen, C1-6 haloalkyl, C1-6 haloalkoxy, —CN, —NO2, —C(O)R6e1, —C(O)OR6e1, —OC(O)R6e1, —C(O)N(R6e1)(R6e2), —N(R6e1)C(O)R6e2, —OC(O)N(R6e1)(R6e2), —N(R6e1)C(O)OR6e2, —C(═NR6e1)N(R6e2)(R6e3), —N(R6e1)(R6e2), ═O, —OR6e, —SR6e1, —S(O)R6e1, —S(NR6e1)(NR6e2), —S(O)(NR6e1)(R6e2), —S(O)2R6e1, —S(O)2N(R6e1)(R6e2), —SF5, —N(R6e1)S(O)2(R6e2), —P(R6e1)(R6e2), —P(O)(R6e1)(R6e2), —P(O)(OR6e1)(R6e2), —P(O)(OR6e1)(OR6e2), —Si(R6e1)(R6e2)(R6e3), C3-10 cycloalkyl, C1-6 alkyl-C3-10 cycloalkyl, C6-12 aryl, C1-6 alkyl-C6-12 aryl, heterocycloalkyl, C1-6 alkyl-heterocycloalkyl, heteroaryl, or C1-6 alkyl-heteroaryl, wherein the cycloalkyl, aryl, heterocycloalkyl, or heteroaryl is each optionally substituted with 1 to 3 R6h which can be the same or different, and the alkyl is optionally substituted with 1 to 3 R6m which can be the same or different;
each R6e1, R6e2, and R6e3 is independently hydrogen, C1-6 alkyl, C1-6 hydroxyalkyl, C1-6 aminoalkyl, C1-6 alkoxyalkyl, C1-6 haloalkyl, C3-10 cycloalkyl, C1-6 alkyl-C3-10 cycloalkyl, C6-10 aryl, C1-6 alkyl-C6-10 aryl, heterocycloalkyl, C1-6 alkyl-(heterocycloalkyl), heteroaryl, or C1-6 alkyl-(heteroaryl), wherein the cycloalkyl, aryl, heterocycloalkyl, or heteroaryl is optionally substituted with 1 to 3 R6n which can be the same or different;
each R6n is C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 hydroxyalkyl, C1-6 aminoalkyl, C1-6 alkoxy, C2-6 alkoxyalkyl, halogen, C1-6 haloalkyl, C1-6 haloalkoxy, —CN, —C(O)R6n1, —C(O)OR6n1, —OC(O)R6n1, —C(O)N(R6n1)(R6n2), —N(R6n1)C(O)R6n2, —OC(O)N(R6n1)(R6n2), —N(R6n1)C(O)OR6n2, —C(═NR6n1)N(R6n2)(R6n3), —N(R6n1)(R6n2), ═O, —OH, —SR6n1, —S(O)R6n1, —S(NR6n1)(NR6n2)R6n3, —S(O)(NR6n1)(R6n2), —S(O)2R6n1, —S(O)2N(R6n1)(R6n2), or —N(R6n1)S(O)2(R6n2);
each R6n1, R6n2 and R6n3 is independently hydrogen, C1-6 alkyl, C1-6 hydroxyalkyl, C1-6 aminoalkyl, C2-6 alkoxyalkyl, C1-6 haloalkyl, C3-10 cycloalkyl, C1-6 alkyl-C3-10 cycloalkyl, C6-10 aryl, C1-6 alkyl-C6-10 aryl, heterocycloalkyl, C1-6 alkyl-(heterocycloalkyl), heteroaryl, or C1-6 alkyl-(heteroaryl);
each R6h is independently C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 hydroxyalkyl, C1-6 aminoalkyl, C1-6 alkoxy, C2-6 alkoxyalkyl, halogen, C1-6 haloalkyl, C1-6 haloalkoxy, —CN, —C(O)R6h1, —C(O)OR6h1, —OC(O)R6h1, —C(O)N(R6h1)(R6h2), —N(R6h1)C(O)R6h2, —OC(O)N(R6h1)(R6h2), —N(R6h1)C(O)OR6h2, —C(═NR6h1)N(R6h2)(R6h3), —N(R6h1)(R6h2), ═O, —OH, —SR6h1, —S(O)R6h1, —S(NR6h1)(NR6h2)R6h3, —S(O)(NR6h1)(R6h2), —S(O)2R6h1, —S(O)2N(R6h1)(R6h2), —N(R6h1)S(O)2(R6h2), C3-10 cycloalkyl, C1-6 alkyl-C3-10 cycloalkyl, heterocycloalkyl, or C1-6 alkyl-(heterocycloalkyl);
each R6h1, R6h2, and R6h3 is independently hydrogen, C1-6 alkyl, C1-6 hydroxyalkyl, C1-6 aminoalkyl, C2-6 alkoxyalkyl, C1-6 haloalkyl, C3-10 cycloalkyl, C1-6 alkyl-C3-10 cycloalkyl, C6-10 aryl, C1-6 alkyl-C6-10 aryl, heterocycloalkyl, C1-6 alkyl-(heterocycloalkyl), heteroaryl, or C1-6 alkyl-(heteroaryl);
each R6m is independently halogen, C1-6 haloalkyl, C1-6 haloalkoxy, —CN, —C(O)R6m1, —C(O)OR6m1, —OC(O)R6m1, —C(O)N(R6m1)(R6m2), —N(R6m3)C(O)R6m2, —OC(O)N(R6m1)(R6m2), —N(R6m1)C(O)OR6m2, —C(═NR6m3)N(R6m1)(R6m2), —N(R6m1)(R6m2), ═O, —OH, —SR6m1, —S(O)R6m1, —S(NR6m1)(NR6m2)R6m3, —S(O)(NR6m1)(R6m2), S(O)2R6m1, —S(O)2N(R6m1)(R6m2), or —N(R6m3)S(O)2(R6m2);
each R6m1, R6m2, and R6 m3 is independently hydrogen, C1-6 alkyl, C1-6 hydroxyalkyl, C1-6 aminoalkyl, C2-6 alkoxyalkyl, C1-6 haloalkyl, C3-10 cycloalkyl, C1-6 alkyl-C3-10 cycloalkyl, C6-10 aryl, C1-6 alkyl-C6-10 aryl, heterocycloalkyl, C1-6 alkyl-(heterocycloalkyl), heteroaryl, or C1-6 alkyl-(heteroaryl);
R6f is —OSi(R6f1)(R6f2)(R6f3);
R6f1, R6f2, and R6f3 are each independently C1-6 alkyl;
each R6j is independently C2-6 alkoxyalkyl, halogen, C1-6 haloalkyl, C1-6 haloalkoxy, —CN, —C(O)R6j1, —C(O)OR6j1, —OC(O)R6j1, —C(O)N(R6j1)(R6j2), —N(R6j3)C(O)R6j2, —OC(O)N(R6j1)(R6j2), —N(R6j1)C(O)OR6j2, —C(═NR6j3)N(R6j1)(R6j2), —N(R6j1)(R6j2), ═O, —OR6j1, —SR6j1, —S(O)R6j1, —S(NR6j1)(NR6j2), —S(NR6j1)(NR6j2)R6j3, —S(O)(NR6j1)(R6j2), —S(O)2R6j1, —S(O)2N(R6j1)(R6j2), —N(R6j1)S(O)2(R6j2), —Si(R6j1)(R6j2)(R6j3), C3-10 cycloalkyl, C6-12 aryl, heterocycloalkyl, or heteroaryl, wherein the cycloalkyl, aryl, heterocycloalkyl, or heteroaryl is optionally substituted with 1 to 3 R6p which can be the same or different;
each R6j1, R6j2, and R6j3 is independently hydrogen, C1-6 alkyl, C1-6 hydroxyalkyl, C1-6 aminoalkyl, C2-6 alkoxyalkyl, C1-6 haloalkyl, C3-10 cycloalkyl, C1-6 alkyl-C3-10 cycloalkyl, C6-10 aryl, C1-6 alkyl-C6-10 aryl, heterocycloalkyl, C1-6 alkyl-(heterocycloalkyl), heteroaryl, or C1-6 alkyl-(heteroaryl);
each R6p is independently C1-6 alkyl, C1-6 hydroxyalkyl, C1-6 aminoalkyl, C1-6 alkoxy, C2-6 alkoxyalkyl, halogen, C1-6 haloalkyl, C1-6 haloalkoxy, —CN, —C(O)R6p1, —C(O)OR6p1, —OC(O)R6p1, —C(O)N(R6p1)(R6p2), —N(R6p1)C(O)R6p2, —OC(O)N(R6p1)(R6p2), —N(R6p1)C(O)OR6p2, —C(═NR6p3)N(R6p1)(R6p2), —N(R6p1)(R6p2), ═O, —OH, —SR6p1, —S(O)R6p1, —S(NR6p1)(NR6p2)R6p3, —S(O)(NR6p1)(R6p2), —S(O)2R6p1, —S(O)2N(R6p1)(R6p2), or —N(R6p1)S(O)2(R6p2);
each R61, R6p2, and R6p3 is independently hydrogen, C1-6 alkyl, C1-6 hydroxyalkyl, C1-6 aminoalkyl, C2-6 alkoxyalkyl, C1-6 haloalkyl, C3-10 cycloalkyl, C1-6 alkyl-C3-10 cycloalkyl, C6-10 aryl, C1-6 alkyl-C6-10 aryl, heterocycloalkyl, C1-6 alkyl-(heterocycloalkyl), heteroaryl, or C1-6 alkyl-(heteroaryl);
or R5 and one R6a together with the atoms to which they are attached form a heterocycloalkyl, optionally substituted with 1 to 3 R6g which can be the same or different;
each R6g is independently C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 hydroxyalkyl, C1-6 aminoalkyl, C2-6 alkoxyalkyl, halogen, C1-6 haloalkyl, C1-6 haloalkoxy, or —CN;
each R7, R8, and R9 is independently hydrogen, C1-6 alkyl, C1-6 hydroxyalkyl, C1-6 aminoalkyl, C1-6 alkoxy, C2-6 alkoxyalkyl, C1-6 alkylthio, halogen, C1-6 haloalkyl, —CN, —OH, —NH2, C3-10 cycloalkyl, C1-6 alkyl-C3-10 cycloalkyl, heterocycloalkyl, or C1-6 alkyl-(heterocycloalkyl); R7, R8, and R9 can be the same or different;
each heterocycloalkyl is a 3 to 20 membered ring having 1 to 4 heteroatoms each independently N, O or S; and
each heteroaryl is a 5 to 18 membered ring having 1 to 4 heteroatoms each independently N, O or S;
provided that at least one of Z7, Z8 and Z9 is N, and when Z7 is CR7 and both Z8 and Z9 are N, at least one of Z1, Z2, and Z4 is N.