Patent ID: 11879145
Assignee: THE SCRIPPS RESEARCH INSTITUTE
Field: Organic fine chemistry (Chemistry)
Classification: CPC C | IPC C

Claim 0:
1. A nucleobase of the structure:, wherein:
each X is independently carbon or nitrogen;
R2 is present when X is carbon and is independently hydrogen, alkyl, alkenyl, alkynyl, methoxy, methanethiol, methaneseleno, halogen, cyano, or azide group;
Y is sulfur, oxygen, or selenium; and
E is sulfur;
wherein the wavy line indicates a point of bonding to a ribosyl, deoxyribosyl, or dideoxyribosyl moiety, wherein the ribosyl, deoxyribosyl, or dideoxyribosyl moiety is optionally modified at the 2′ position, at the 3′ position, or at the 5′ position, wherein the ribosyl, deoxyribosyl, or dideoxyribosyl moiety is in free form, is connected to a mono-phosphate, diphosphate, triphosphate, α-thiotriphosphate, β-thiotriphosphate, or γ-thiotriphosphate group, or is included in a polynucleotide, optionally wherein the polynucleotide is an RNA, DNA, bicyclic nucleic acid, linked nucleic acid, peptide nucleic acid (PNA), locked nucleic acid (LNA), or a phosphorothioate-containing nucleic acid.