Patent ID: 11890285
Assignee: MIRATI THERAPEUTICS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 37:
38. The method according to claim 1, wherein the KRas G12C-associated cancer is selected from the group consisting of
Cardiac: sarcoma selected from angiosarcoma, fibrosarcoma, rhabdomyosarcoma, and liposarcoma, myxoma, rhabdomyoma, fibroma, lipoma and teratoma;
Lung: bronchogenic carcinoma selected from squamous cell, undifferentiated small cell, undifferentiated large cell, and adenocarcinoma, alveolar carcinoma, bronchiolar carcinoma, bronchial adenoma, sarcoma, lymphoma, chondromatous hamartoma, mesothelioma, and non-small cell lung cancer;
Gastrointestinal: esophagus selected from squamous cell carcinoma, adenocarcinoma, leiomyosarcoma, and lymphoma, stomach selected from carcinoma, lymphoma, and leiomyosarcoma, pancreas selected from ductal adenocarcinoma, insulinoma, glucagonoma, gastrinoma, carcinoid tumors, and vipoma, small bowel selected from adenocarcinoma, lymphoma, carcinoid tumors, Kaposi's sarcoma, leiomyoma, hemangioma, lipoma, neurofibroma, and fibroma, large bowel selected from adenocarcinoma, tubular adenoma, villous adenoma, hamartoma, and leiomyoma;
Genitourinary tract: kidney selected from adenocarcinoma, Wilm's tumor (nephroblastoma), lymphoma, and leukemia, bladder and urethra selected from squamous cell carcinoma, transitional cell carcinoma, and adenocarcinoma, prostate selected from adenocarcinoma and sarcoma, testis selected from seminoma, teratoma, embryonal carcinoma, teratocarcinoma, choriocarcinoma, sarcoma, interstitial cell carcinoma, fibroma, fibroadenoma, adenomatoid tumors, and lipoma;
Liver: hepatoma selected from hepatocellular carcinoma, cholangiocarcinoma, hepatoblastoma, angiosarcoma, hepatocellular adenoma, and hemangioma;
Biliary tract: gall bladder carcinoma, ampullary carcinoma, and cholangiocarcinoma;
Bone: osteogenic sarcoma, fibrosarcoma, malignant fibrous histiocytoma, chondrosarcoma, Ewing's sarcoma, malignant lymphoma, multiple myeloma, malignant giant cell tumor chordoma, osteochronfroma, benign chondroma, chondroblastoma, chondromyxofibroma, osteoid osteoma and giant cell tumors;
Nervous system: skull selected from osteoma, hemangioma, granuloma, xanthoma, and osteitis deformans, meninges selected from meningioma, meningiosarcoma, and gliomatosis, brain selected from astrocytoma, medulloblastoma, glioma, ependymoma, germinoma, glioblastoma multiform, oligodendroglioma, schwannoma, retinoblastoma, congenital tumors, and spinal cord neurofibroma;
Gynecological: uterus selected from endometrial carcinoma, granulosa-thecal cell tumors, Sertoli-Leydig cell tumors, dysgerminoma, and malignant teratoma, vulva selected from squamous cell carcinoma, intraepithelial carcinoma, adenocarcinoma, fibrosarcoma, and melanoma, vagina selected from clear cell carcinoma, squamous cell carcinoma, botryoid sarcoma, and fallopian tubes;
Hematologic: selected from blood selected from myeloid leukemia, acute lymphoblastic leukemia, chronic lymphocytic leukemia, myeloproliferative diseases, multiple myeloma, and myelodysplastic syndrome, Hodgkin's disease, and non-Hodgkin's lymphoma;
Skin: malignant melanoma, basal cell carcinoma, squamous cell carcinoma, Kaposi's sarcoma, moles dysplastic nevi, lipoma, angioma, dermatofibroma, keloids, psoriasis; and
Adrenal glands: neuroblastoma.