Patent ID: 11859211
Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A method for engraftment of non-naturally occurring satellite cells for treating a muscle disorder, the method comprising administering to a subject in need thereof a pharmaceutical composition comprising therapeutically effective amount of an isolated population of non-naturally occurring satellite cells, wherein:
the non-naturally occurring satellite cells have a gene expression profile that is different from the gene expression profile of an endogenous satellite cell;
the non-naturally occurring satellite cells express two or more genes selected from the group consisting of: Nr2f1, Dmpl, Wisp2/Ccn5, Ecm1, Mgp, Igfbp5, Itgb5, Sdc2 and Bgn, wherein the expression of the two or more genes is upregulated by greater than 2-fold relative to expression by myoblasts and the two or more genes are not expressed in an endogenous satellite cell;
the non-naturally occurring satellite cells have capacity to repopulate the satellite cell niche; and
the non-naturally occurring satellite cells cause muscle regeneration following transplantation.