Patent ID: 11874282
Assignee: ROCHE DIAGNOSTICS OPERATIONS, INC.
Field: Measurement (Instruments)
Classification: CPC G | IPC G

Claim 7:
8. A method for monitoring preeclampsia or a preeclampsia-related condition in a pregnant subject suffering from preeclampsia or a preeclampsia-related condition selected from the group consisting of eclampsia, HELLP syndrome and proteinuria, comprising the steps of
(a) measuring the amount of the polypeptide biomarker IGFBP-7 in a first sample from the subject,
(b) measuring the amount of the polypeptide biomarker IGFBP-7 in a second sample from the subject,
(c) comparing the amount of the biomarker in the second sample to the amount of the biomarker in the first sample;
(d) based on the comparison of step (c), identifying an increase in the severity of preeclampsia or a preeclampsia-related condition in the subject when the amount of IGFBP-7 in the second sample is increased as compared to the amount of IGFBP-7 in the first sample; and
(e) administering one or more of corticosteroids, magnesium sulfate and blood pressure reducing agents to the subject identified as having an increase in the severity of preeclampsia or a preeclampsia-related condition.