Patent ID: 11965854
Assignee: RADIOMETER MEDICAL APS
Field: Measurement (Instruments)
Classification: CPC G  C | IPC C  G

Claim 0:
1. A method for recalibrating a measuring device for measuring a concentration of creatinine in a solution using one or more calibration solutions, the method comprising:
providing the measuring device for determining the concentration of creatinine in the solution, wherein the measuring device comprises a sensor having a sensitivity in need of recalibration;
providing the one or more calibration solutions comprising a creatine (Cr) calibration solution and/or a creatinine (Crn) calibration solution for the sensor;
receiving concentrations at an initial time of Cr and/or Crn in the one or more calibration solutions;
receiving outputs of the measuring device at an end time;
calculating the concentration of Cr and/or Crn in the one or more calibration solutions at the end time using a two-temperature temperature model, rate equations for an equilibrium reaction of Cr and Crn, and the Arrhenius equation,
wherein the two-temperature temperature model is determined by receiving measurements of one or more changes in temperature of the one or more calibration solutions from one or more temperature probes from the initial time to the end time;

determining the sensitivity of the sensor based on a relationship between the outputs of the measuring device and the calculated concentration of Cr and/or Crn, and
recalibrating the sensitivity of the sensor for subsequent determination of the concentration of Cr and/or Crn in a sample.