Patent ID: 11938154
Assignee: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A

Claim 0:
1. An endothelial progenitor cell-derived exosome, wherein the endothelial progenitor cell-derived exosome comprises one or more modifications that enhance expression of an miR-126 microRNA in the endothelial progenitor cell-derived exosome; and further wherein at least one of the one or more modifications comprises introduction of a heterologous nucleotide sequence that comprises, consists essentially of, or consists of, and/or that encodes, one or more of SEQ ID NOs: 1 and/or 3 into an endothelial progenitor cell from which the endothelial progenitor cell-derived exosome is derived, whereby the expression of the miR-126 microRNA in the endothelial progenitor cell-derived exosome is enhanced relative to the expression of the miR-126 microRNA in an endothelial progenitor cell-derived exosome isolated from an untreated endothelial progenitor cell-derived exosome.