Patent ID: 11945834
Assignee: BRISTOL-MYERS SQUIBB COMPANY
Field: Organic fine chemistry (Chemistry)
Classification: CPC C  A | IPC C

Claim 6:
7. The compound according to claim 1 of the formula, , wherein
X is independently O or S;
X1, X2, X3 and X4 are each independently O or NH;
R1 and R2 are independently, , with the proviso that one of R1 and R2 must be, each Z1 is independently N or CRa;
Z2 is NRb;
Ra is H, halogen, C1-6 alkyl substituted with 0-6 R5, C3-6 cycloalkyl substituted with 0-6 R5, CN, NO2, OH, ORa1, SRa1, —C(O)NRa1Ra1, —COORa1, —OC(O)Ra1, —OC(O)NRa1Ra1, —NRa1Ra1, —NRa1C(O)Ra1, —NRa1COORa1, —NRa1C(O)NRa1Ra1, —NRa1S(O)2Ra1, —NRa1S(O)2NRa1Ra1, —S(O)Ra1, —S(O)NRa1Ra1, —S(O)2Ra1 or S(O)2NRa1Ra1;
Rb is H, C1-6 alkyl substituted with 0-6 R5, C3-6 cycloalkyl substituted with 0-6 R5, —C(O)Ra1, —C(O)NRa1Ra1, —S(O)2Ra1 or S(O)2NRa1Ra1;
Ra1 is H, C1-3 alkyl or C3-6 cycloalkyl;
R3 and R4 are independently H, CH3, halogen, —NRa1Ra1 or ORa1;
R5 is H, halogen, C1-3 alkyl substituted with 0-6 Ra, C3-6 cycloalkyl substituted with 0-6 Ra, aryl substituted with 0-6 Ra or heteroaryl substituted with 0-6 Ra, CN, NO2, OH, ORa1, SRa1, —C(O)NRa1Ra1, —COORa1, —OC(O)Ra1, —OC(O)NRa1Ra1, —NRa1Ra1, —NRa1C(O)Ra1, —NRa1COORa1, —NRa1C(O)NRa1Ra1, —NRa1S(O)2Ra1, —NRa1S(O)2NRa1Ra1, —S(O)Ra1, —S(O)NRa1Ra1, —S(O)2Ra1 or S(O)2NRa1Ra1;
R5a is H or C1-3 alkyl substituted with 0-6 R5;
R6 is H, halogen, C1-3 alkyl substituted with 0-6 R5, CN, NO2, OH, ORa1, SRa1, —C(O)NRa1Ra1, —COORa1, —OC(O)Ra1, —OC(O)NRa1Ra1, —NRa1Ra1, —NRa1C(O)Ra1, —NRa1COORa1, —NRa1C(O)NRa1Ra1, —NRa1S(O)2Ra1, —NRa1S(O)2NRa1Ra1, —S(O)Ra1, —S(O)NRa1Ra1, —S(O)2Ra1 or S(O)2NRa1Ra1;
R8 is H, halogen, C1-3 alkyl substituted with 0-6 R5, CN, NO2, OH, ORa1, SRa1, —C(O)NRa1Ra1, —COORa1, —OC(O)Ra1, —OC(O)NRa1Ra1, —NRa1Ra1, —NRa1C(O)Ra1, —NRa1COORa1, —NRa1C(O)NRa1Ra1, —NRa1S(O)2Ra1, —NRa1S(O)2NRa1Ra1, —S(O)Ra1, —S(O)NRa1Ra1, —S(O)2Ra1 or S(O)2NRa1Ra1;
each Y is independently CRa or N;
m is 0, 1, 2 or 3;
or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof.