Patent ID: 11873507
Assignee: REPLICATE BIOSCIENCE, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 10:
11. The nucleic acid construct of claim 1, wherein the polypeptide construct comprises, in N-terminus to C-terminus direction:
a) an IL-12A polypeptide, an IL-12B polypeptide, and an IL-1RA polypeptide; or;
b) an IL-1RA polypeptide, an IL-12B polypeptide, and an IL-12A polypeptide;, wherein the IL-12A, IL-12B, and IL-1RA polypeptides are operably linked to one another by one or more autoproteolytic cleavage sequences or IRES.