Patent ID: 11970497
Assignee: NOVARTIS AG
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 15:
16. A compound selected from:
6′-fluoro-N-((5-methylfuran-2-yl)methyl)-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′-fluoro-N-(4-fluoro-2-methoxybenzyl)-1′-methyl-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′-fluoro-N-(4-fluoro-3-(2-hydroxyethoxy)benzyl)-1′-methyl-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
4-((6′-fluoro-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamido)methyl)phenyl dihydrogen phosphate;
N-(2,4-difluorobenzyl)-6′-fluoro-1′-methyl-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
1′-ethyl-6′-fluoro-N-(4-fluorobenzyl)-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′-fluoro-1′-methyl-N-((5-methylfuran-2-yl)methyl)-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′-fluoro-N-(4-fluoro-3-methoxybenzyl)-1′-methyl-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′-fluoro-N-(4-fluorobenzyl)-1′-methyl-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′,8′-difluoro-N-((2-methylfuran-3-yl)methyl)-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
N-(3-carbamoyl-4-fluorobe;nzyl)-6′,8′-difluoro-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide
6′-fluoro-N-((4-fluorophenyl)methyl-d2)-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
N-(3-carbamoyl-4-fluorobenzyl)-1′-ethyl-6′-fluoro-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′-fluoro-N-(4-fluorobenzyl)-1′-(2-methoxyethyl)-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′-fluoro-N-(4-fluoro-3-(oxazol-5-yl)benzyl)-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
N-(2,4-difluorobenzyl)-6′-fluoro-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
N-(2,4-difluoro-5-((2-hydroxyethyl)amino)benzyl)-6′-fluoro-1′-methyl-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
N-(2,4-difluoro-5-((2-hydroxyethyl)amino)benzyl)-1′-ethyl-6′-fluoro-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′-fluoro-N-(4-fluorobenzyl)-1′-(2-hydroxyethyl)-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′-fluoro-N-(4-fluoro-2-((2-methoxyethyl)amino)benzyl)-1′-methyl-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′-fluoro-N-(4-fluoro-3-((2-methoxyethyl)amino)benzyl)-1′-methyl-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
N-((5-chlorofuran-2-yl)methyl)-6′-fluoro-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′-fluoro-N-(4-fluoro-3-((1-methylethyl)sulfonamido)benzyl)-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
N-(3-carbamoyl-4-fluorobenzyl)-6′-fluoro-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
1′-ethyl-6′-fluoro-N-(4-fluoro-3-((2-hydroxyethyl)amino)benzyl)-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
N-(3-amino-2,4-difluorobenzyl)-1′-ethyl-6′-fluoro-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
N-(3-amino-4-fluorobenzyl)-6′-fluoro-1′-methyl-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
2-((2-fluoro-5-((6′-fluoro-1′-methyl-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamido)methyl)phenyl)amino)ethyl dihydrogen phosphate;
N-(3-amino-4-fluorobenzyl)-1′-ethyl-6′-fluoro-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′-fluoro-N-(4-fluoro-3-sulfamoylbenzyl)-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
N-(3-(((1,4-dioxan-2-yl)methyl)amino)-4-fluorobenzyl)-6′-fluoro-1′-methyl-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′-fluoro-N-(4-fluoro-3-((4-(hydroxymethyl)benzyl)carbamoyl)benzyl)-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
N-benzyl-6′-fluoro-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide
N-((2,4-dimethylfuran-3-yl)methyl)-6′-fluoro-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′,8′-difluoro-N-(3-(oxazol-5-yl)benzyl)-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′-fluoro-N-(4-fluoro-3-((2-hydroxyethyl)amino)benzyl)-1′-methyl-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
N-((1H-pyrazol-4-yl)methyl)-6′-fluoro-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
N-((4-carbamoylfuran-2-yl)methyl)-6′,8′-difluoro-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′-fluoro-N-(4-hydroxybenzyl)-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′-fluoro-N-(4-fluorobenzyl)-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
N-(3-carbamoyl-4-fluorobenzyl)-6′-fluoro-1′-methyl-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
N-(3-amino-2,4-difluorobenzyl)-6′-fluoro-1′-methyl-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′-fluoro-N-(4-fluoro-2-hydroxybenzyl)-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
N-(3-((2,2-dimethyl-3-(4-methylpiperazin-1-yl)-3-oxopropyl)amino)-4-fluorobenzyl)-6′-fluoro-1′-methyl-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
(S)-N-(3-((2,3-dihydroxypropyl)amino)-4-fluorobenzyl)-6′-fluoro-1′-methyl-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′,8′-difluoro-N-(furan-3-ylmethyl)-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
N-((1H-pyrazol-3-yl)methyl)-6′-fluoro-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′-fluoro-N-(4-fluoro-3-((2-hydroxyethyl)carbamoyl)benzyl)-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
N-(4-amino-2,5-difluorobenzyl)-6′-fluoro-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
N-(5-amino-2,4-difluorobenzyl)-1′-ethyl-6′-fluoro-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′-fluoro-N-(4-fluoro-2-(2,2,2-trifluoroethoxy)benzyl)-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
N-(2-(ethylamino)-4-fluorobenzyl)-6′-fluoro-1′-methyl-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
N-(benzo[d][1,3]dioxol-4-ylmethyl)-6′,8′-difluoro-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′,8′-difluoro-N-(4-hydroxybenzyl)-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′-fluoro-N-(4-fluoro-3-(methylsulfonamido)benzyl)-1′-methyl-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
N-(4-amino-3-fluorobenzyl)-6′-fluoro-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
N-(4-amino-2,3-difluorobenzyl)-6′-fluoro-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′-fluoro-N-(4-fluoro-3-((2-methoxyethyl)carbamoyl)benzyl)-1′-methyl-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′-fluoro-N-((2-methylfuran-3-yl)methyl)-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′-fluoro-N-(4-fluoro-3-((3-hydroxycyclobutyl)carbamoyl)benzyl)-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
Methyl 2-fluoro-5-((6′-fluoro-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamido)methyl)benzoate;
N-(3-(2-amino-2-oxoethyl)-4-fluorobenzyl)-6′-fluoro-1′-methyl-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′,8′-difluoro-N-((3-hydroxypyridin-2-yl)methyl)-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′-fluoro-N-(4-fluoro-3-(methylcarbamoyl)benzyl)-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
N-(4-amino-3,5-difluorobenzyl)-6′-fluoro-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
N-((6-(dimethylamino)pyridin-2-yl)methyl)-6′,8′-difluoro-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′-fluoro-N-(4-fluoro-2-(trifluoromethyl)benzyl)-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
N-(2-chloro-4-fluorobenzyl)-6′-fluoro-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
N-(3-carbamoylbenzyl)-6′-fluoro-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′-fluoro-N-(4-fluoro-3-(2-hydroxyethoxy)benzyl)-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
N-(2,4-difluoro-5-(2-hydroxyethoxy)benzyl)-6′-fluoro-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′-fluoro-N-((5-methyl-1H-pyrazol-3-yl)methyl)-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
N-(3-amino-4-fluorobenzyl)-6′,8′-difluoro-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′-fluoro-4′-oxo-N-(3-sulfamoylbenzyl)-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
N-(2,4-difluoro-3-((2-hydroxyethyl)amino)benzyl)-1′-ethyl-6′-fluoro-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
N-(4-aminobenzyl)-6′-fluoro-1′-methyl-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
N-(2,4-difluoro-5-((2-hydroxyethyl)amino)benzyl)-6′-fluoro-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′-fluoro-N-(4-fluoro-3-((2-hydroxyethyl)amino)benzyl)-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
N-(3-carbamoyl-4-fluoro-2-methylbenzyl)-6′-fluoro-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
N-(4-amino-2,6-difluorobenzyl)-6′-fluoro-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
N-(3-((2-(dimethylamino)ethyl)carbamoyl)-4-fluorobenzyl)-6′-fluoro-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′-fluoro-N-(4-fluoro-3-((2-hydroxyethyl)carbamoyl)benzyl)-1′-methyl-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′-fluoro-N-(4-fluoro-3-(hydroxymethyl)benzyl)-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
N-(3-amino-2,4-difluorobenzyl)-6′-fluoro-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
(E)-1′-(but-2-en-1-yl)-6′-fluoro-N-(4-fluorobenzyl)-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′-fluoro-N-(4-fluoro-2-((2-hydroxyethyl)amino)benzyl)-1′-methyl-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
N-(4-amino-3-chlorobenzyl)-6′-fluoro-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′-fluoro-N-(4-fluoro-3-((2-hydroxypropyl)carbamoyl)benzyl)-1′-methyl-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
N-(4-aminobenzyl)-6′-fluoro-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′-fluoro-N-(4-fluoro-3-((2-(2-oxopyrrolidin-1-yl)ethyl)amino)benzyl)-1′-methyl-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
N-(2,4-difluoro-3-((2-hydroxyethyl)amino)benzyl)-6′-fluoro-1′-methyl-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′-fluoro-N-(4-fluoro-3-(1-hydroxyethyl)benzyl)-1′-methyl-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
N-((4-chloro-1-methyl-1H-pyrazol-5-yl)methyl)-6′-fluoro-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
(R)-6′-fluoro-N-(4-fluoro-3-((2-hydroxypropyl)carbamoyl)benzyl)-1′-methyl-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
N-(3-amino-4-fluorobenzyl)-6′-fluoro-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′-fluoro-4′-oxo-N-((2-(trifluoromethyl)furan-3-yl)methyl)-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′-fluoro-N-(4-fluoro-3-((2-hydroxy-2-methylpropyl)carbamoyl)benzyl)-1′-methyl-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
N-(4-amino-2-fluorobenzyl)-6′-fluoro-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′-fluoro-N-(4-fluoro-3-((2-methoxyethyl)amino)benzyl)-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
N-(3-((2-cyclopropyl-2-oxoethyl)carbamoyl)-4-fluorobenzyl)-6′-fluoro-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′-fluoro-N-(4-fluoro-3-((2,2,2-trifluoroethyl)carbamoyl)benzyl)-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′-fluoro-N-(4-fluoro-3-(3-methoxyazetidin-1-yl)benzyl)-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
N-(3-(2-amino-2-oxoethyl)-4-fluorobenzyl)-6′-fluoro-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
N-(4-amino-2-(trifluoromethyl)benzyl)-6′-fluoro-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′-fluoro-N-(4-fluoro-3-(oxetan-3-ylcarbamoyl)benzyl)-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
N-((3-ethyl-5-methylisoxazol-4-yl)methyl)-6′-fluoro-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′-fluoro-N-(isoxazol-4-ylmethyl)-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
N-(4-(difluoromethoxy)-3-fluorobenzyl)-6′,8′-difluoro-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
N-(3-carbamoyl-2,4-difluorobenzyl)-6′-fluoro-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
N-((2,5-dimethylfuran-3-yl)methyl)-6′-fluoro-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
N-(4-amino-2-chlorobenzyl)-6′-fluoro-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
N-(4-amino-3-(trifluoromethyl)benzyl)-6′-fluoro-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
N-(3-((2,2-dimethyl-3-morpholino-3-oxopropyl)amino)-4-fluorobenzyl)-6′-fluoro-1′-methyl-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′-fluoro-N-(4-fluoro-2-methoxybenzyl)-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′,8′-difluoro-N-((2-methoxypyridin-4-yl)methyl)-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
N-(4-amino-2-methylbenzyl)-6′-fluoro-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
(S)-6′-fluoro-N-(4-fluoro-3-((2-hydroxypropyl)carbamoyl)benzyl)-1′-methyl-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′-fluoro-N-(isoxazol-3-ylmethyl)-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
N-(4-amino-3-methylbenzyl)-6′-fluoro-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
N-((1H-indol-6-yl)methyl)-6′-fluoro-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′-fluoro-N-(4-fluoro-3-(((2-methyloxazol-5-yl)methyl)carbamoyl)benzyl)-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
(E)-6′-fluoro-N-(4-fluoro-3-((4-hydroxybut-2-en-1-yl)carbamoyl)benzyl)-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′,8′-difluoro-N-((5-methylthiophen-2-yl)methyl)-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′-fluoro-N-(isoxazol-5-ylmethyl)-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′,8′-difluoro-N-((6-fluoropyridin-3-yl)methyl)-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
N-(5-amino-2,4-difluorobenzyl)-6′-fluoro-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′-fluoro-N-((5-methyl-2-(trifluoromethyl)furan-3-yl)methyl)-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′-fluoro-N-(4-fluoro-3-(prop-2-yn-1-ylcarbamoyl)benzyl)-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′,8′-difluoro-N-(3-(hydroxymethyl)benzyl)-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
N-(3-(1H-imidazol-2-yl)benzyl)-6′-fluoro-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′-fluoro-N-(4-fluoro-3-(methylsulfonamido)benzyl)-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′,8′-difluoro-N-(4-fluoro-3-(hydroxymethyl)benzyl)-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
N-(3-(cyclopropanesulfonamido)-4-fluorobenzyl)-6′-fluoro-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′-fluoro-N-((3-methyl-1,2,4-oxadiazol-5-yl)methyl)-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′-fluoro-N-(4-fluoro-3-(1-hydroxyethyl)benzyl)-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
N-((6-aminopyridin-3-yl)methyl)-6′-fluoro-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
N-(2-amino-4-fluorobenzyl)-6′-fluoro-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′-fluoro-N-(oxazol-4-ylmethyl)-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′-fluoro-N-(4-fluoro-3-(2-hydroxypropan-2-yl)benzyl)-1′-methyl-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
3-((2-fluoro-5-((6′-fluoro-1′-methyl-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamido)methyl)phenyl)amino)-2,2-dimethylpropanoic acid;
N-(benzo[c][1,2,5]oxadiazol-4-ylmethyl)-6′-fluoro-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
N-(3-carbamoyl-4-fluorobenzyl)-6′-fluoro-8′-methyl-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′-fluoro-N-(4-fluoro-3-(propylcarbamoyl)benzyl)-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
N-(3-(1H-1,2,4-triazol-1-yl)benzyl)-6′,8′-difluoro-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′-fluoro-N-((1-methyl-1H-pyrazol-4-yl)methyl)-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′-fluoro-N-(4-fluoro-3-(((2-hydroxyethyl)amino)methyl)benzyl)-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′-fluoro-N-(4-fluoro-3-(sulfamoylmethyl)benzyl)-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
3-((2-fluoro-5-((6′-fluoro-1′-methyl-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamido)methyl)phenyl)amino)propanoic acid;
(R)-N-(3-(1-amino-2,2,2-trifluoroethyl)-4-fluorobenzyl)-6′-fluoro-1′-methyl-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
N-(4-(difluoromethoxy)benzyl)-6′,8′-difluoro-4′-oxo-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
(R)-6′-fluoro-N-(4-fluorobenzyl)-4′-hydroxy-1′-methyl-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
(S)-6′-fluoro-N-(4-fluorobenzyl)-4′-hydroxy-1′-methyl-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
(R)-6′-fluoro-N-(4-fluorobenzyl)-4′-hydroxy-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
(S)-6′-fluoro-N-(4-fluorobenzyl)-4′-hydroxy-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
(R)-6′-fluoro-N-(4-fluoro-2-hydroxybenzyl)-4′-hydroxy-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
(S)-6′-fluoro-N-(4-fluoro-2-hydroxybenzyl)-4′-hydroxy-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide:
N-(3-carbamoyl-4-fluorobenzyl)-6′-fluoro-4′-hydroxy-1′-methyl-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
N-(2,4-difluoro-5-((2-hydroxyethyl)amino)benzyl)-6′-fluoro-4′-hydroxy-1′-methyl-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
N-(3-carbamoyl-4-fluorobenzyl)-6′,8′-difluoro-4′-hydroxy-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
N-(3-amino-4-fluorobenzyl)-6′-fluoro-4′-hydroxy-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′-fluoro-N-(4-fluoro-3-(hydroxymethyl)benzyl)-4′-hydroxy-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
N-(3-carbamoyl-4-fluorobenzyl)-6′-fluoro-4′-hydroxy-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
N-(3-(2-amino-2-oxoethyl)-4-fluorobenzyl)-6′-fluoro-4′-hydroxy-1′-methyl-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′-fluoro-N-(4-fluoro-3-((3-hydroxycyclobutyl)carbamoyl)benzyl)-4′-hydroxy-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′-fluoro-N-(4-fluoro-3-(2-hydroxyethoxy)benzyl)-4′-hydroxy-1′-methyl-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′-fluoro-N-(4-fluoro-3-(methylsulfonamido)benzyl)-4′-hydroxy-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′-fluoro-N-(4-fluoro-3-((2-hydroxyethyl)amino)benzyl)-4′-hydroxy-1′-methyl-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′-fluoro-N-(4-fluoro-2-((2-methoxyethyl)amino)benzyl)-4′-hydroxy-1′-methyl-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
N-(3-((R)-1-amino-2,2,2-trifluoroethyl)-4-fluorobenzyl)-6′-fluoro-4′-hydroxy-1′-methyl-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
6′-fluoro-N-(4-fluoro-2-methoxybenzyl)-4′-hydroxy-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
(R)-6′-fluoro-4′-hydroxy-N-((2-methylfuran-3-yl)methyl)-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
(R)-N-(4-amino-3-fluorobenzyl)-6′-fluoro-4′-hydroxy-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide; and
(S)—N-(4-amino-3-fluorobenzyl)-6′-fluoro-4′-hydroxy-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline]-1-carboxamide;
or a pharmaceutically acceptable salt thereof.