Patent ID: 11932640
Assignee: KING FAISAL UNIVERSITY
Field: Organic fine chemistry (Chemistry)
Classification: CPC C  A  Y | IPC A  C

Claim 0:
1. A method of treating a bacterial infection in a patient, comprising administering to a patient in need thereof a therapeutically effective amount of a compound, wherein the compound has the formula I:, , or a pharmaceutically acceptable salt, ester, stereoisomer, or solvate thereof, wherein:
R1 is a C1-C6 alkyl or a C3-C6 cycloalkyl;
R2 is hydrogen or a halogen;
R3 is hydrogen, —OR6, —NH2, —NHR7, or —NR7R8; and
R4 and R5, which may independently be the same or different, each represent:
a hydrogen atom,
a linear or branched C1-C6 polyhaloalkyl group,
—OR6, wherein each R6 may independently be the same or different and may each represent a hydrogen atom, an aryl group, a heteroaryl group, or a linear or branched C1-C6 polyhaloalkyl or a linear or branched C1-C6 alkyl group or a C3-C6 cycloalkyl group, each of which can be optionally substituted by a carboxylic acid group, by a group of formula —CONR7R8, or by a group of formula —NR7R8, wherein each R7 and R8, which may be the same or different, each represent hydrogen, a linear or branched C1-C6 alkyl group optionally substituted by one or more of a hydroxy group or an amino group (itself optionally substituted by one or two linear or branched C1-C6 alkyl groups), a C3-C8 cycloalkyl group, an aryl group optionally substituted by one or more of a C1-C6 alkyl group, a C1-C6 alkoxy group, or a halogen, or R7 and R8, taken together with the nitrogen atom to which they are attached, form a nitrogen-containing heterocycle ring which may be further substituted with a C1-C6 alkyl group,
—COR9, wherein R9 represents:
a hydroxy group,
—OR6,
an amino group,
an amino group substituted by one or more aryl groups, heteroaryl groups, or linear or branched C1-C6 alkyl groups or C3-C8 cycloalkyl groups, each of which can be optionally substituted by a carboxylic acid group, by a group of formula —CONR7R8, or by a group of formula —NR7R8, wherein R7 and R8 may be the same or different,
a linear or branched C1-C6 alkyl group optionally substituted by a carboxylic acid group, or by a group of formula —CONR7R8 or —NR7R8, wherein R7 and R8 may be the same or different,
a C3-C8 cycloalkyl group;
a C1-C6 polyhalogen alkyl group; or
—OPO(OH)2,

—CH2NR7R8,
—CH2COR9, or
—CH2OR6;

wherein the bacterial infection is caused by Gram-positive Staphylococcus aureus, Staphylococcus aureus resistant to MRSA, Staphylococcus epidermidis, Bacillus subtilis, Enterococcus faecium, B Enterococcus faecium resistant to VRE, or Gram-negative Klebsiella pneumonia, Escherichia coli, or Pseudomonas aeruginosa.