Patent ID: 11860123
Assignee: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
Field: Measurement (Instruments)
Classification: CPC G  C  B | IPC B  C  G

Claim 0:
1. An apparatus comprising:
a database comprising a dictionary of reference signals, each of the reference signals corresponding to one of methyl-CpG binding domain (MBD-1) protein, methyl CpG binding protein 2 (MeCP2), or γcyclodextrin (GCD);
a membrane, wherein the membrane has a first side and a second side, wherein the membrane has a pore disposed therein, wherein the pore extends through the membrane from the first side of the membrane to the second side of the membrane;
a processing system including a processor; and
a memory that stores executable instructions that, when executed by the processing system, facilitate performance of operations, the operations comprising:
electronic sensing of an electrical characteristic associated with a translocation of a test DNA through the pore, wherein a feature of the test DNA comprises an epigenetic biomarker, and wherein the electronic sensing is performed by an electric current along the membrane that results in a sensed electrical characteristic;
comparing the sensed electrical characteristic with each of the reference signals of the dictionary, wherein the comparing results in a comparison result; and
determining, based upon the comparison result, with which of the reference signals of the dictionary the sensed electrical characteristic corresponds, resulting in a corresponding reference signal, wherein the determining comprises determining that at least a first correlation peak between the corresponding reference signal and the sensed electrical characteristic is above a threshold and that at least a second correlation peak between the corresponding reference signal and the sensed electrical characteristic is above the threshold.