Patent ID: 11890319
Assignee: VISTERRA, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 0:
1. An antibody molecule-drug conjugate (ADC) comprising an anti-LPS antibody molecule and a covalently coupled antimicrobial peptide, wherein the antibody molecule comprises one or more motifs, wherein:
(I) the one or more motifs have the formula:

X1(FGly′)X2Z2X3Z3 

wherein FGly′ is a 2-formylglycine residue, a cysteine, or a serine;
Z2 is a proline or alanine residue;
X1, X2, and X3 are each independently any amino acid;
Z3 is a basic amino acid; and

(II) the antibody molecule comprises:
(i) a heavy chain comprising a heavy chain variable region (VH) comprising:
(a) an HCDR1 comprising the amino acid sequence of SEQ ID NO: 108, an HCDR2 comprising the amino acid sequence of SEQ ID NO: 146, and an HCDR3 comprising the amino acid sequence of SEQ ID NO: 107; or
(b) an HCDR1 comprising the amino acid sequence of SEQ ID NO: 105, an HCDR2 comprising the amino acid sequence of SEQ ID NO: 106, and an HCDR3 comprising the amino acid sequence of SEQ ID NO: 107; and/or

(ii) a light chain comprising a light chain variable region (VL) comprising: an LCDR1 comprising the amino acid sequence of SEQ ID NO: 138, an LCDR2 comprising the amino acid sequence of SEQ ID NO: 142, and an LCDR3 comprising the amino acid sequence of any of SEQ ID NO: 112; and

(III) the antimicrobial peptide comprises the amino acid sequence of GGGKFFRKLKKSVKKRAKEFFKKPRVIGVSIPF (SEQ ID NO: 156).