Patent ID: 11859220
Assignee: THE GENERAL HOSPITAL CORPORATION
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 2:
3. The complex of claim 1, wherein the mutations are:
(i) D1135E (D1135E variant);
(ii) D1135V/R1335Q/T1337R (VQR variant);
(iii) D1135V/G1218R/R1335Q/T1337R (VRQR variant);
(iv) D1135E/R1335Q/T1337R (EQR variant);
(v) D1135N/G1218R/R1335Q/T1337R (NRQR variant);
(vi) D1135Y/G1218R/R1335Q/T1337R (YRQR variant);
(vii) G1104K/D1135V/G1218R/R1335Q/T1337R (KVRQR variant);
(viii) S1109T/D1135V/G1218R/R1335Q/T1337R (TVRQR variant);
(ix) L1111H/D1135V/G1218R/R1335Q/T1337R (HVRQR variant);
(x) D1135V/S1136N/G1218R/R1335Q/T1337R (VNRQR variant);
(xi) D1135V/G1218R/N1317K/R1335Q/T1337R (VRKQR variant); or
(xii) D1135V/G1218R/R1335E/T1337R (VRER variant).