Patent ID: 11946867
Assignee: MEMORIAL SLOAN KETTERING CANCER CENTER
Field: Measurement (Instruments)
Classification: CPC G | IPC G

Claim 17:
18. An interferometric modulation imaging apparatus for multi-color interferometric imaging of at least one fluorescent sample, comprising:
one or more excitation sources;
a first optical objective and a second optical objective, the first optical objective configured to (i) focus a frequency modulated excitation beam from the one or more excitation sources toward the at least one fluorescent sample located in a volume between the first optical objective and the second optical objective, and for it collecting a first portion of light provided from the sample, wherein the second optical objective is located within a first distance from the first objective so as to (i) focus the frequency modulated excitation beam toward the at least one fluorescent sample, and (ii) collect a second portion of light provided from the sample;
a dichroic mirror configured to (i) direct the frequency modulated excitation beam having different frequencies, and (ii) combine the first portion of the provided light with the second portion of the provided light to form an interference signal;
one or more phase modulating devices are arranged to:
direct the frequency modulated excitation beam from the one or more beam splitters to the first optical objective, and
direct the first portion of the provided light collected at the first optical objective to the one or more beam splitters;

a first set of mirrors arranged to:
direct the frequency modulated beam from the one or more beam splitters to the second optical objective, and
direct the second portion of emitted light collected at the second optical objective to the one or more beam splitters; and

one or more detectors configured to detect the interference signal.