Patent ID: 11944644
Assignee: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 4:
5. The T-cell of claim 1, characterized by at least one of:
(i) the costimulatory domain is selected from a costimulatory domain of CD28, 4-1BB, OX40, iCOS, CD27, CD80, CD70 and the activation domain is selected from an FcRγ and CD3-ζ activation domain;
(ii) the activation domain is FcRγ activation domain having the amino acid sequence of SEQ ID NO: 23 and the costimulatory domain is a costimulatory domain of CD28 having the amino acid sequence of SEQ ID NO: 22; and
(iii) the peptide linker is a peptide having the amino acid sequence of SEQ ID NO: 17.