Patent ID: 11866421
Assignee: EPIGEN BIOSCIENCES, INC.
Field: Organic fine chemistry (Chemistry)
Classification: CPC C | IPC C

Claim 18:
19. The pharmaceutically acceptable formulation of claim 17, wherein the compound is 6-(1-Benzyl-1H-pyrazol-4-yl)-5-(p-chlorophenyl)-4-pyrimidinylamine, 5-(p-Chlorophenyl)-6-(1-methyl-1H-pyrazol-4-yl)-4-pyrimidinylamine, 5-(p-Chlorophenyl)-6-(1-{1-[m-(trifluoromethyl)phenyl]ethyl}-1H-pyrazol-4-yl)-4-pyrimidinylamine, 5-(p-Chlorophenyl)-6-(1-{1[p-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)-4-pyrimidinylamine, (R,S)-2-{4-[6-Amino-5-(p-chlorophenyl)-4-pyrimidinyl]-1H-pyrazol-1-yl}-2-phenylethanol, (R,S)-6-[1-(2-Amino-1-phenylethyl)-1H-pyrazol-4-yl]-5-(p-chlorophenyl)-4-pyrimidinamine, 5-(p-Chlorophenyl)-6-[1-(1-phenylethenyl)-1H-pyrazol-4-yl]-4-pyrimidinylamine, (R,S)-{4-[6-Amino-5-(p-chlorophenyl)-4-pyrimidinyl]-1H-pyrazol-1-yl}phenylacetamide, (R,S)—N,N-Dimethyl{4-[6-amino-5-(p-chlorophenyl)-4-pyrimidinyl]-1H-pyrazol-1-yl}phenylacetamide, 5-(p-Chlorophenyl)-6-(1-phenyl-1H-pyrazol-4-yl)-4-pyrimidinylamine, 5-(p-Chlorophenyl)-6-[1-(o-tolyl)-1H-pyrazol-4-yl]-4-pyrimidinylamine, 5-(p-Chlorophenyl)-6-[1-(m-chlorophenyl)-1H-pyrazol-4-yl]-4-pyrimidinylamine, 5-(p-Chlorophenyl)-6-{1-[m-(trifluoromethyl)phenyl]-1H-pyrazol-4-yl}-4-pyrimidinylamine, 5-(p-Chlorophenyl)-6-[1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl]-4-pyrimidinylamine, 5-(p-Chlorophenyl)-6-{1-[(m-fluorophenyl)methyl]-1H-pyrazol-4-yl}-4-pyrimidinylamine, 5-(p-Chlorophenyl)-6-{1-[(p-chlorophenyl)methyl]-1H-pyrazol-4-yl}-4-pyrimidinylamine, 5-(p-Chlorophenyl)-6-(1-{[o-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)-4-pyrimidinylamine, 5-(p-Chlorophenyl)-6-{1-[(p-fluorophenyl)methyl]-1H-pyrazol-4-yl}-4-pyrimidinylamine, 5-(p-Chlorophenyl)-6-{1-[(2,4-difluorophenyl)methyl]-1H-pyrazol-4-yl}-4-pyrimidinylamine, 5-(p-Chlorophenyl)-6-{1-[(p-trifluoromethoxyphenyl)methyl]-1H-pyrazol-4-yl}-4-pyrimidinylamine, 5-(p-Chlorophenyl)-6-{1-[(o-fluorophenyl)methyl]-1H-pyrazol-4-yl}-4-pyrimidinylamine, {1-[6-Amino-5-(p-chlorophenyl)-4-pyrimidinyl]-1H-pyrazol-4-yl}phenylmethanone, 6-(4-Benzyl-1H-pyrazol-1-yl)-5-(p-chlorophenyl)-4-pyrimidinylamine, 5-(p-Methoxyphenyl)-6-(1-{[p-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)-4-pyrimidinylamine, 5-(p-Fluorophenyl)-6-(1-{[p-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)-4-pyrimidinylamine, 5-[p-(Methylsulfonyl)phenyl]-6-(1-1{[p-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)-4-pyrimidinylamine, 5-(4-Chloro-3-fluorophenyl)-6-(1-{[p-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)-4-pyrimidinylamine, 5-(3,4-Dichlorophenyl)-6-(1-{[p-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)-4-pyrimidinylamine, 5-(4-Chloro-3-methoxyphenyl)-6-(1-{[p-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)-4-pyrimidinylamine, 5-(3-Chloro-4-methoxyphenyl)-6-(1-{[p-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)-4-pyrimidinylamine, 5-(3,4-Difluorophenyl)-6-(1-{[p-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)-4-pyrimidinylamine, 5-(3-Fluoro-4-methoxyphenyl)-6-(1-{[p-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)-4-pyrimidinylamine, 5-(4-Fluoro-3-methoxyphenyl)-6-(1-{[p-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)-4-pyrimidinylamine, 5-(p-Trifluoromethoxyphenyl)-6-(1-{[p-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)-4-pyrimidinylamine, 5-(2,2-Difluoro-2H-1,3-benzodioxol-5-yl)-6-(1-{[p-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)-4-pyrimidinylamine, 4-(1-{[p-(Trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)-2-pyridylamine, 5-Chloro-4-(1-{[p-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)-2-pyridylamine, 3-(p-Methoxyphenyl)-4-(1-{[p-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)-2-pyridylamine, 3-(p-Chlorophenyl)-4-(1-{[p-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)-2-pyridylamine, 5-(4-Chloro-3-fluorophenyl)-6-(1-{[p-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)-4-pyrimidinylamine, 5-(3-Fluoro-4-methoxyphenyl)-6-(1-{[p-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)-4-pyrimidinylamine, 5-(1H-Pyrazol-4-yl)-6-(1-{[p-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)-4-pyrimidinylamine, and pharmaceutically acceptable salts thereof.