Patent ID: 11965006
Assignee: UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A  Y | IPC A  C

Claim 0:
1. A method of treating a microbial infection in a subject in need thereof comprising administering to the subject a therapeutically effective amount of a composition comprising one or more antimicrobial peptides (AMPs) comprising a helical amphipathic structure provided in formula I:, wherein the formula I numbering refers to an order of 18 contiguous amino acid residues within the AMPs from an N-terminal to a C-terminal direction and wherein amino acid residues 1, 4, 5, 8, 11, 12, 15, and 16 are hydrophobic amino acids, and amino acid residues 2, 3, 6, 7, 9, 10, 13, 14, 17, and 18 are any non-hydrophobic or hydrophilic amino acids, wherein the one or more AMPs comprise a sequence selected from the group consisting of ILKKWWββαβGLLGβLLGαVββVIKβLββI (SEQ ID NO 2), LKKWWKβαKGLLGGLLGKVββVIK (SEQ ID NO 12), and αKKααKKαKGαLGGLαGK (SEQ ID NO 18) wherein α is a hydrophobic amino acid selected from the group consisting of the L or D form of the following: alanine, isoleucine, leucine, tryptophan, phenylalanine, valine, proline, and glycine and wherein β is a non-hydrophobic or hydrophilic amino acid selected from the group consisting of the L or D form of the following: arginine, lysine, aspartic acid, glutamic acid, glutamine, asparagine, histidine, serine, threonine, tyrosine, cysteine, methionine, selenocysteine, and pyrrolysine, wherein the microbial infection is caused by a microbe selected from the group consisting of Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumonia, Pseudomonas aeruginosa, Mycobacterium tuberculosis, Escherichia coli, Enterobacteriaceae, Acinetobacter baumannii, and respiratory syncytial virus.