Patent ID: 11860154
Assignee: LEUKO LABS, INC.
Field: Measurement (Instruments)
Classification: CPC G | IPC G

Claim 22:
23. A method to determine a density of red blood cells from non-invasive capillary videos, the method comprising:
acquiring a first plurality of images of a region of interest including one or more capillaries of a predetermined area of a human subject from non-invasive capillary videos captured with an optical device;
processing the first plurality of images to determine one or more area of hemoglobin optical absorption gaps located in said capillary;
annotating the first plurality of images with an indication of any area of hemoglobin optical absorption gaps detected in the first plurality of images;
acquiring a second plurality of images of the same region of interest of the same capillary with an advanced optical device capable of resolving cellular structure of red blood cells;
spatiotemporally annotating the second plurality of images with an indication of a density of any red blood cells detected in the second plural of images; and
inputting the first plurality of images and annotated information from the first plurality of images and annotated information from the spatiotemporally annotated second plurality of images into a machine learning subsystem configured to determine the density of any red blood cell cells present in the one or more optical absorption gaps.