Patent ID: 11898210
Assignee: ENTEROME
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A method for treating a human subject suffering from Crohn Disease (CD), said method comprising the steps of:
a) isolating a nucleotide fraction of a stool sample from said subject,
b) detecting expression of the fimH gene in said nucleotide fraction by measuring the switch of the Escherichia coli fim operon transcription from OFF to ON in a nucleotide fraction of said stool sample to calculate an ON/(ON+OFF) ratio of the fimH gene, and comparing the ON/(ON+OFF) ratio with a reference value of 15%,
c) administering a mannose derivative FimH blocker to subjects whose nucleotide fraction has an ON/(ON+OFF) ratio higher than said reference value of 15%.