Patent ID: 11919835
Assignee: ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD
Field: Organic fine chemistry (Chemistry)
Classification: CPC C | IPC C

Claim 0:
1. A method for preparing pregabalin comprising:
reacting a compound of formula (I) in a first solvent with a biological enzyme to produce a target compound of formula (III) and a by-product of formula (II);
reacting the by-product of formula (II) in a second solvent with an isomerase to perform a configuration inversion to produce a compound of formula (IV);
reacting the compound of formula (IV) in a third solvent with the biological enzyme to produce the target compound of formula (III);, , wherein:
R1 and R2 are independently hydrogen or an alkyl group; and
the biological enzyme is a hydrolase.