Patent ID: 11925684
Assignee: AMGEN RESEARCH (MUNICH) GMBH
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 0:
1. A bispecific single chain antibody comprising:
(i) a first binding domain which binds to primate CD3 comprising
CDR-L1 (SEQ ID NO: 118), CDR-L2 (SEQ ID NO: 117), and CDR-L3 (SEQ ID NO: 116) and CDR-H1 (SEQ ID NO: 115), CDR-H2 (SEQ ID NO: 114) and CDR-H3 (SEQ ID NO: 112) or (SEQ ID NO: 113),
wherein the first binding domain comprises a VH region comprising the amino acid sequence set forth in SEQ ID NO: 110 and/or a VL region comprising the amino acid sequence set forth in SEQ ID NO: 168; and

(ii) a second binding domain binding to a cell surface antigen.