Patent ID: 11866502
Assignee: REGENERON PHARMACEUTICALS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 40:
41. An antibody-drug conjugate comprising an anti-FGFR2 antibody, or an antigen-binding fragment thereof, conjugated to a camptothecin analog, wherein the antibody-drug conjugate has the following structure:, , wherein n is a value between 2 and 12; and, wherein Ab is the anti-FGFR2 antibody or antigen-binding fragment thereof, wherein the anti-FGFR2 antibody or antigen-binding fragment thereof comprises an HCDR1 comprising the amino acid sequence of SEQ ID NO:4, an HCDR2 comprising the amino acid sequence of SEQ ID NO:6, an HCDR3 comprising the amino acid sequence of SEQ ID NO:8, an LCDR1 comprising the amino acid sequence of SEQ ID NO:12, an LCDR2 comprising the amino acid sequence of SEQ ID NO:14, and an LCDR3 comprising the amino acid sequence of SEQ ID NO:16.