Patent ID: 11963963
Assignee: SPRINT BIOSCIENCE AB
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 0:
1. A process for preparing a compound represented by Formula (I):, wherein
R1, R2 and R3 are independently selected from the group consisting of hydrogen, C1-C3haloalkyl and C1-C3alkyl;
A represents, wherein
X is selected from the group consisting of CH2, S, SO, SO2, NR5, NCOR5, NCOR9, NCOCH2R9, and a bond;
Y is selected from the group consisting of N, CH and C;
n is selected from the group consisting of 1, 2, 3 and 4;
R4 is selected from the group consisting of hydrogen, halogen, COR6, C1-C6alkyl, C1-C3alkoxyC1-C3alkyl, C1-C6alkoxy, C3-C6cycloalkyl, C3-C6heterocyclyl, C1-C3cyanoalkyl, C1-C3haloalkyl, aryl and heteroaryl, wherein said aryl and said heteroaryl are optionally substituted with one or more R7;
R5 is selected from the group consisting of hydrogen, C1-C3fluoroalkyl, C1-C3alkyl, C1-C3alkoxyC1-C3alkyl and C3-C6cycloalkyl;
R6 is selected from the group consisting of C1-C3alkoxy, N—C1-C3alkylamino, N,N-diC1-C3alkylamino, 1-pyrrolidinyl, 1-piperidinyl and 1-azetidinyl;
R7 is selected from the group consisting of C1-C6alkyl, C3-C6cycloalkyl, C1-C3alkoxyC1-C3alkyl, C1-C3haloalkyl, halogen, N—C1-C3alkylamino, N,N-diC1-C3alkylamino, C1-C3haloalkoxy and C1-C3alkoxy;
R9 is selected from the group consisting of C1-C3alkyl, C1-C3alkoxy, C3-C6cycloalkyl, heterocyclyl, phenyl and a monocyclic heteroaryl, wherein said heterocyclyl, said phenyl and said monocyclic heteroaryl are optionally substituted with one or two R8; and
R8 is selected from the group consisting of halogen, C1-C3haloalkyl and C1-C3alkyl;

and pharmaceutically acceptable salts, stereoisomers and tautomers thereof;
the process comprising:
(i) providing a compound represented by Formula (III):, wherein
R1, R2, R3, and A are as defined as above;
R10 is selected from the group consisting of F, OCH3, OC(CH3)3, and OSiR′R″R′″; and
R′, R″, and R′″ are each independently aryl or alkyl; and
(ii) converting the compound represented by Formula (III) into the compound represented by Formula (I).