Patent ID: 11858997
Assignee: ABLYNX N.V.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 4:
5. A polypeptide according to claim 1, wherein the polypeptide:
a) has at least 80% amino acid identity with at least one of the amino acid sequences of SEQ ID NOs: 505-511; in which for the purposes of determining the degree of amino acid identity, the amino acid residues that form the CDR sequences are disregarded;, and in which:
b) one or more of the amino acid residues at positions 11, 37, 44, 45, 47, 83, 84, 103, 104 and 108 according to the Kabat numbering are chosen from:
at position 11: L, M, S, V, or W;
at position 37: F, Y, H, I, L, or V;
at position 44: G, E, A, D, Q, R, S, or L;
at position 45: L, R, C, I, P, Q, or V;
at position 47: W, L, F, A, G, I, M, R, S, V, or Y;
at position 83: R, K, N, E, G, I, M, Q, or T;
at position 84: P, A, L, R, S, T, D, or V;
at position 103: W, P, R, or S;
at position 104: G, or D; and
at position 108: Q, L, or R.