Patent ID: 11926827
Assignee: ELI LILLY AND COMPANY
Field: Biotechnology (Chemistry)
Classification: CPC C | IPC C

Claim 26:
27. The MAPT RNAi agent of claim 1, wherein the sense strand and the antisense strand have a pair of nucleic acid sequences selected from the group consisting of:
(a) the sense strand consists of SEQ ID NO: 63, and the antisense strand consists of SEQ ID NO: 40;
(b) the sense strand consists of SEQ ID NO: 39, and the antisense strand consists of SEQ ID NO: 40;
(c) the sense strand consists of SEQ ID NO: 64, and the antisense strand consists of SEQ ID NO: 65;
(d) the sense strand consists of SEQ ID NO: 66, and the antisense strand consists of SEQ ID NO: 65;
(e) the sense strand consists of SEQ ID NO: 64, and the antisense strand consists of SEQ ID NO: 70;
(f) the sense strand consists of SEQ ID NO: 71, and the antisense strand consists of SEQ ID NO: 65;
(g) the sense strand consists of SEQ ID NO: 64, and the antisense strand consists of SEQ ID NO: 72;
(h) the sense strand consists of SEQ ID NO: 64, and the antisense strand consists of SEQ ID NO: 73;
(i) the sense strand consists of SEQ ID NO: 64, and the antisense strand consists of SEQ ID NO: 74;
(j) the sense strand consists of SEQ ID NO: 75, and the antisense strand consists of SEQ ID NO: 65;
(k) the sense strand consists of SEQ ID NO: 76, and the antisense strand consists of SEQ ID NO: 65;
(l) the sense strand consists of SEQ ID NO: 77, and the antisense strand consists of SEQ ID NO: 65;
(m) the sense strand consists of SEQ ID NO: 78, and the antisense strand consists of SEQ ID NO: 65;
(n) the sense strand consists of SEQ ID NO: 79, and the antisense strand consists of SEQ ID NO: 65;
(o) the sense strand consists of SEQ ID NO: 80, and the antisense strand consists of SEQ ID NO: 65;
(p) the sense strand consists of SEQ ID NO: 81, and the antisense strand consists of SEQ ID NO: 65;
(q) the sense strand consists of SEQ ID NO: 82, and the antisense strand consists of SEQ ID NO: 65;
(r) the sense strand consists of SEQ ID NO: 83, and the antisense strand consists of SEQ ID NO: 65;
(s) the sense strand consists of SEQ ID NO: 84, and the antisense strand consists of SEQ ID NO: 65;
(t) the sense strand consists of SEQ ID NO: 85, and the antisense strand consists of SEQ ID NO: 65;
(u) the sense strand consists of SEQ ID NO: 86, and the antisense strand consists of SEQ ID NO: 65;
(v) the sense strand consists of SEQ ID NO: 93, and the antisense strand consists of SEQ ID NO: 65;
(w) the sense strand consists of SEQ ID NO: 94, and the antisense strand consists of SEQ ID NO: 65;
(x) the sense strand consists of SEQ ID NO: 95, and the antisense strand consists of SEQ ID NO: 65;
(y) the sense strand consists of SEQ ID NO: 96, and the antisense strand consists of SEQ ID NO: 65;
(z) the sense strand consists of SEQ ID NO: 97, and the antisense strand consists of SEQ ID NO: 65;
(aa) the sense strand consists of SEQ ID NO: 98, and the antisense strand consists of SEQ ID NO: 65;
(bb) the sense strand consists of SEQ ID NO: 99, and the antisense strand consists of SEQ ID NO: 65;
(cc) the sense strand consists of SEQ ID NO: 100, and the antisense strand consists of SEQ ID NO: 65;
(dd) the sense strand consists of SEQ ID NO: 105, and the antisense strand consists of SEQ ID NO: 65;
(ee) the sense strand consists of SEQ ID NO: 105, and the antisense strand consists of SEQ ID NO: 106;
(ff) the sense strand consists of SEQ ID NO: 105, and the antisense strand consists of SEQ ID NO: 107;
(gg) the sense strand consists of SEQ ID NO: 105, and the antisense strand consists of SEQ ID NO: 108; and
(hh) the sense strand consists of SEQ ID NO: 115, and the antisense strand consists of SEQ ID NO: 116.