Patent ID: 11946925
Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Field: Measurement (Instruments)
Classification: CPC G  B  C | IPC B  C  G

Claim 35:
36. A nanopore sensor comprising:
a nanopore disposed in a support structure, the nanopore having a nanopore diameter and a nanopore fluidic resistance, RPore;
a first fluidic reservoir including a fluidic solution having a first ionic concentration;
a fluidic passage disposed in fluidic connection between the first fluidic reservoir and the nanopore, the fluidic passage including a planar passage length disposed laterally in a material layer disposed on the support structure, the planar passage length winding around itself laterally in the material layer, the fluidic passage having a fluidic passage width, along at least a portion of a fluidic passage length, that is greater than the diameter of the nanopore and less than the fluidic passage length, and the fluidic passage having a fluidic passage fluidic resistance, RFP, of at least about 10% of the nanopore fluidic resistance, Rpore, and no more than about 10 times the nanopore fluidic resistance, RPore;
a second fluidic reservoir including a fluidic solution having a second ionic concentration, the nanopore being disposed in fluidic connection between the second fluidic reservoir and the fluidic passage; and
at least one electrical transduction element disposed at the fluidic passage and electrically connected to sense electrical potential local to the fluidic passage.