Patent ID: 11957764
Assignee: SOUTH CHINA UNIVERSITY OF TECHNOLOGY
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 0:
1. A multi-specific antibody delivery platform, which is formed by bonding a protein-type nanoparticle with an anti-Fc antibody through a chemical bond, wherein
the protein-type nanoparticle includes polyester and a protein with a hydrophobic domain, and the hydrophobic domain of the protein is bound with the polyester through hydrophobic interaction, wherein the protein is albumin or a cell wall protein, and the protein has a same species as a recipient of the delivered specific antibody, wherein
the anti-Fc antibody is an anti-IgG-Fc antibody;
a weight ratio of the polyester to the protein is within a range of 1:(9-11);
a Fab domain of the anti-Fc antibody is non-covalently bound with an Fc domain of a delivered specific antibody; and
the delivered specific antibody has a same species as an Fc segment recognized by the anti-Fe antibody.