Patent ID: 11964941
Assignee: CITY OF HOPE
Field: Organic fine chemistry (Chemistry)
Classification: CPC C | IPC A  C

Claim 0:
1. A method of treating acute myeloid leukemia expressing a FLT3-kinase in a subject in need thereof, said method comprising administering an effective amount of a compound having the formula:, wherein,
L is a substituted or unsubstituted alkylene;
R1 is —NR2R3;
R2 and R3 are independently substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl, wherein R2 and R3 are optionally joined together to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl; and
R5 and R6 are independently hydrogen or halogen;
including pharmaceutically acceptable salts thereof,, thereby treating said acute myeloid leukemia.