Patent ID: 11893731
Assignee: VENTANA MEDICAL SYSTEMS, INC.
Field: Computer technology (Electrical engineering)
Classification: CPC G | IPC G

Claim 0:
1. A method comprising:
accessing an image depicting a biological sample stained with a set of biomarkers;
accessing a reference color matrix, wherein the reference color matrix includes co-localization data for the set of biomarkers, wherein the co-localization data defines a plurality of groups of biomarkers within the set of biomarkers, each group of biomarkers of the plurality of groups of biomarkers including a subset of biomarkers of the set of biomarkers, wherein a first biomarker and a second biomarker of a subset of biomarkers of a first group of biomarkers of the plurality of groups of biomarkers represent a first common biological structure;
unmixing, based on the co-localization data of the reference color matrix, the image to generate a result that identifies, for one or more pixels of the image, a sparsity model that represents a first estimated fraction of contribution of the first biomarker and a second estimated fraction of contribution of the second biomarker; and
outputting the result.