Patent ID: 11919969
Assignee: KYMAB LIMITED
Field: Biotechnology (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A bispecific antigen-binding molecule comprising:
a FIXa binding polypeptide arm comprising a FIXa binding site, and
a FX binding polypeptide arm comprising a FX binding site
wherein the FIXa binding site is provided by a set of complementarity determining regions (CDRs) in the FIXa binding polypeptide arm, the set of CDRs comprising HCDR1, HCDR2 and HCDR3, wherein HCDR1 is SEQ ID NO: 1, HCDR2 is SEQ ID NO: 2 and HCDR3 is SEQ ID NO: 171, and LCDR1, LCDR2 and LCDR3, wherein LCDR1 is SEQ ID NO: 6, LCDR2 is SEQ ID NO: 7 and LCDR3 is SEQ ID NO: 8;
wherein the FX binding site is provided by a set of CDRs in the FX binding polypeptide arm, the set of CDRs selected from the group consisting of:
(i) HCDR1 is SEQ ID NO: 67, HCDR2 is SEQ ID NO: 68 and HCDR3 is SEQ ID NO: 69, and LCDR1 is SEQ ID NO: 72, LCDR2 is SEQ ID NO: 73 and LCDR3 is SEQ ID NO: 74;
(ii) HCDR1 is SEQ ID NO: 57, HCDR2 is SEQ ID NO: 58 and HCDR3 is SEQ ID NO: 59, and LCDR1 is SEQ ID NO: 62, LCDR2 is SEQ ID NO: 63 and LCDR3 is SEQ ID NO: 64;
(iii) HCDR1 is SEQ ID NO: 96, HCDR2 is SEQ ID NO: 97 and HCDR3 is SEQ ID NO: 98, and LCDR1 is SEQ ID NO: 101, LCDR2 is SEQ ID NO: 92 and LCDR3 is SEQ ID NO: 102; and
(iv) HCDR1 is SEQ ID NO: 77, HCDR2 is SEQ ID NO: 78 and HCDR3 is SEQ ID NO: 79, and LCDR1 is SEQ ID NO: 62, LCDR2 is SEQ ID NO: 82 and LCDR3 is SEQ ID NO: 83.