Patent ID: 11883406
Assignee: SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 5:
6. A method for producing an alginic acid-folic acid conjugate comprising steps of:
a) introducing a protecting group to a carboxyl group of alginic acid;
b) introducing a leaving group to a carboxyl group of folic acid; and
c) obtaining a reaction product between the alginic acid to which the protecting group has been introduced in step a) and the folic acid to which the leaving group has been introduced in step b), wherein the protecting group in step a) is an unsubstituted or substituted benzyl group, trimethylsilyl, t-butyldimethylsilyl, t-butyldiphenylsilyl, a substituted or unsubstituted alkyl group having 1 to 4 carbon atoms, or tetrabutylammonium, and wherein the leaving group in step b) is a methanesulfonyl group, a p-toluenesulfonyl group, a trifluoromethanesulfonyl group, an alkoxy group having 1 to 5 carbon atoms, a halogen or imidazole.