Patent ID: 11958833
Assignee: MISSION THERAPEUTICS LIMITED
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A compound of formula (I):, a tautomer thereof, or a pharmaceutically acceptable salt of said compound or tautomer, wherein:
R1b, R1c, R1d and R1e are each independently selected from hydrogen and C1-C6 alkyl;
R1a and R1g are each independently selected from hydrogen, fluorine, cyano, hydroxyl, amino, C1-C6 alkyl and C1-C6 alkoxy;
R1f is selected from hydrogen, fluorine, cyano, hydroxyl, amino, C1-C6 alkyl and C1-C6 alkoxy;
R2 is selected from hydrogen and C1-C6 alkyl;
X is C(R3)(R4), wherein R3 and R4 are each independently selected from hydrogen, cyano and C1-C6 alkyl;
L is a covalent bond;
A is selected from a 5 to 6-membered monocyclic heteroaryl ring and a 9 to 10-membered bicyclic heteroaryl ring;
wherein ring A is substituted with one to four -Q1-(R6)n, wherein each occurrence of -Q1-(R6)n is the same or different;
n is 0 or 1;
when n is 0, Q1 is selected from halogen, cyano, oxo, nitro, —OR7, —SR7, —NR7R8, —CONR7R8, —NR7COR8, —NR7CONR8R9, —COR7, —C(O)OR7, —NR7C(O)OR8, C1-C6 alkyl and C1-C6 alkoxy;
when n is 1, Q1 is selected from a covalent bond, an oxygen atom and C1-C6 alkylene;
R7 and R8 are each independently selected from hydrogen and C1-C6 alkyl;
R6 is selected from 5 to 6-membered monocyclic heteroaryl, 9 to 10-membered bicyclic heteroaryl, cyclopropyl, phenyl and naphthyl;
wherein R6 is optionally substituted with one to four substituents, each independently selected from halogen, cyano, oxo, nitro, —OR10, —SR10, —NR10R11, C1-C6 alkyl and C1-C6 alkoxy;
R10 and R11 are each independently selected from hydrogen and C1-C6 alkyl; and
wherein said C1-C6 alkyl and C1-C6 alkoxy groups are optionally substituted with one to four substituents, each independently selected from halogen, hydroxyl, thiol, cyano, amino, nitro and SF5.