Patent ID: 11939300
Assignee: IMMUNOMOLECULAR THERAPEUTICS, INC.
Field: Organic fine chemistry (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 6:
7. A method of treating an autoimmune disease selected from the group consisting of celiac disease, type 1 diabetes, Stiff-person syndrome, Addison's disease, Schmidt syndrome, and Myasthenia gravis in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of Formula (I),, , or a pharmaceutically acceptable salt thereof, wherein
R1 is H, optionally substituted C1-C6-alkyl; optionally substituted aryl; optionally substituted C3-C7-cycloalkyl; optionally substituted heterocyclyl; or optionally substituted heteroaryl;
R2 is H, optionally substituted C1-6 alkyl, or OR4 wherein R4 is H or optionally substituted C1-6 alkyl;
R3 is H, optionally substituted C1-C6-alkyl, optionally substituted C3-C8-cycloalkyl; optionally substituted aryl; optionally substituted heteroaryl; optionally substituted heterocyclyl; or —(CH2)n—Y, where n is 1-4 and Y is optionally substituted C3-C8-cycloalkyl; optionally substituted 3 to 8 membered heterocyclyl; optionally substituted aryl; optionally substituted heteroaryl; optionally substituted C1-C6-alkoxy; —C(O)OH or —C(O)N(R8)2;
each R8 is independently H or C1-C6-alkyl; and, X is N or CR5; wherein R5 is H or optionally substituted C1-6 alkyl;, wherein
each heteroaryl is selected from the group consisting of pyridinyl, pyrazinyl, pyrimidinyl, pyrrolyl, pyrazolyl, imidazolyl, thiazolyl, oxazolyl, isooxazolyl, thiadiazolyl, oxadiazolyl, thiophenyl, furanyl, quinolinyl, isoquinolinyl, benzimidazolyl, benzoxazolyl, and quinoxalinyl,
each heterocyclyl is selected from the group consisting of 1,3-dioxolane, pyrrolidinyl, pyrazolinyl, pyrazolidinyl, imidazolinyl, imidazolidinyl, piperidinyl, piperazinyl, oxazolidinyl, isoxazolidinyl, morpholinyl, thiazolidinyl, isothiazolidinyl, 2-azabicyclo[2.2.1]-heptyl, 8-azabicyclo[3.2.1]octyl, 5-azaspiro[2.5]octyl, 7-oxooxepan-4-yl, tetrahydropyranyl, and tetrahydrofuryl, and each optionally substituted group is optionally substituted with 1 or more substituents independently selected from the group consisting of halogen, C1-C4-alkyl, halo-C1-C4-alkyl, C2-C4-alkenyl, halo-C2-C4-alkenyl, C3-C6-cycloalkyl, C1-C4-alkoxy, halo-C1-C4-alkoxy, —CN, OH, NH2, C1-C4-alkylamino, di(C1-C4-alkyl)amino, and NO2.