Patent ID: 11959076
Assignee: 10X GENOMICS, INC.
Field: Biotechnology (Chemistry)
Classification: CPC C | IPC C

Claim 1:
2. The method of claim 1, wherein analyzing the second analyte in the second biological sample mounted on the third substrate comprises:
separating the first substrate from the second substrate;
hybridizing a third probe and a fourth probe to the second analyte in the second biological sample, wherein the third probe and the fourth probe each comprise a sequence that is substantially complementary to sequences of the second analyte, wherein the fourth probe comprises a second capture probe binding domain, and wherein the third probe or the fourth probe comprises a second sample index sequence that identifies the second biological sample;
coupling the third probe and the fourth probe, thereby generating a second connected probe;
when the at least a portion of the second biological sample is aligned with at least a portion of the array, releasing the second connected probe from the second analyte; and
hybridizing the second connected probe to a second capture domain of a second capture probe on the array, wherein the second capture probe comprises a second spatial barcode.