Patent ID: 11969426
Assignee: GENENTECH, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 2:
3. A process for the preparation of amorphous ipatasertib monohydrochloride suitable for a pharmaceutical composition comprising ipatasertib monohydrochloride and one or more pharmaceutically acceptable excipients selected from the group consisting of a filler, a binder, and a disintegrant, the process comprising the steps of:
(a) dissolving a solvate of ipatasertib in a solvent, thereby forming a feed solution;
(b) feeding the feed solution into a spray-dryer unit;
(c) atomizing the feed solution in the drying chamber to yield a mist;
(d) mixing the mist with a drying gas thereby evaporating the solvent and forming amorphous ipatasertib monohydrochloride powder;
(e) separating the amorphous ipatasertib monohydrochloride powder from the drying gas; and
(f) collecting the amorphous ipatasertib monohydrochloride powder.