Patent ID: 11957680
Assignee: AGIOS PHARMACEUTICALS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 12:
13. A method of treating hereditary spherocytosis, hereditary elliptocytosis, abetalipoproteinemia or Bassen-Kornzweig syndrome, sickle cell disease, paroxysmal nocturnal hemoglobinuria, anemia, hemolytic anemia, acquired hemolytic anemia, or anemia of chronic diseases in a subject in need thereof, a method of increasing amount of hemoglobin in a subject in need thereof, a method of increasing the lifetime of red blood cells (RBCs) in a subject in need thereof, a method for regulating 2,3-diphosphoglycerate levels in blood in a subject in need thereof, or a method for activating pyruvate kinase R (PKR) in red blood cells in a subject in need thereof, comprising administering to a subject an effective amount of a compound according to claim 1 or a pharmaceutically acceptable salt thereof.