Patent ID: 11944648
Assignee: SEATTLE CHILDREN'S HOSPITAL
Field: nan (nan)
Classification: CPC nan | IPC A  C

Claim 0:
1. A polypeptide comprising a CD19-OR-CD20 chimeric antigen receptor (CAR), wherein the CAR comprises from N- to C-terminus:
a) an anti-CD20 scFv with a variable heavy domain and a variable light domain obtained from ofatumumab;
b) a (G4S)n linker, wherein n is 1 (SEQ ID NO: 15), 3 (SEQ ID NO: 16), or 4 (SEQ ID NO: 19);
c) an anti-CD19 scFv comprising a variable heavy domain from SEQ ID NO:4 and a variable light domain from SEQ ID NO:4;
d) a spacer of SEQ ID NO:5;
e) a transmembrane domain of SEQ ID NO:6;
f) a co-stimulatory domain of SEQ ID NO:8; and
g) a CD3-zeta cytoplasmic signaling domain of SEQ ID NO:9.