Patent ID: 11858962
Assignee: nan
Field: Measurement (Instruments)
Classification: CPC C  G | IPC C  G

Claim 0:
1. A polypeptide comprising
an ectodomain of a rhabdovirus glycoprotein, and
a heterologous multimerization domain linked to the ectodomain,
wherein the ectodomain is an ectodomain of a SF-rhabdovirus glycoprotein having
at amino acid position 306 an amino acid residue other than an arginine residue, and/or
at amino acid position 303 an amino acid residue other than an arginine residue, and/or
at amino acid position 305 an amino acid residue other than a basic amino acid residue, and/or
at amino acid position 307 an amino acid residue selected from the group consisting of lysine residue, leucine residue, isoleucine residue, valine residue and tryptophane residue, and/or
at amino acid position 308 a lysine residue,

and having
at amino acid position 333 an amino acid residue other than an arginine residue, and/or
at amino acid position 330 an amino acid residue other than an arginine residue, and/or
at amino acid position 332 an amino acid residue other than a basic amino acid residue, and/or
at amino acid position 334 an amino acid residue selected from the group consisting of lysine residue, leucine residue, isoleucine residue, valine residue and tryptophane residue, and/or
at amino acid position 335 a lysine residue,

and wherein the numbering of the amino acid positions refers to the amino acid sequence of wild type SF-rhabdovirus glycoprotein as set forth in SEQ ID NO:16,
and wherein the heterologous multimerization domain comprises or consists of a IgG Fc domain.