Patent ID: 11970552
Assignee: GLO PHARMA, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A muscle-type nicotinic acetylcholine receptor peptide antagonist comprising an amino acid sequence:, Xaa3 - Xaa4 - Xaa5 - Xaa6 - Xaa7 - Xaa8 - Xaa9 - 

 

Xaa10 - Xaa11 - Xaa12 - Xaa13 - Xaa14

wherein:
Xaa3 and Xaa8 form a linkage Xaa3-Xaa8;
Xaa4 and Xaa14 form a linkage Xaa4-Xaa14;
Xaa5 is selected from: Asn, Asp, Gln, Glu, Arg, His and Lys;
Xaa6 is selected from: Pro and hydroxyproline;
Xaa7 is selected from: Ala, Gly, Val, Leu, and Ile;
Xaa9 is selected from: Ala, Gly, Val, Leu, and Ile;
Xaa10 is selected from: His and Lys;
Xaa11 is selected from: Asp, Gln, Glu, Arg, His, and Lys;
Xaa12 is selected from: Trp and Tyr;
Xaa13 is selected from: Cys, Met, Sec, Ser, Thr, Arg, His, and Lys;
wherein Xaa3 and Xaa14 are terminal amino acids.