Patent ID: 11884750
Assignee: CELLTROY CO., LTD.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 0:
1. A method of delivering a biologically active molecule into a subject or cells, comprising:
(S1) preparing a cell penetrating peptide;
(S2) binding the biologically active molecule to the cell penetrating peptide to prepare a complex comprising the cell penetrating peptide and the biologically active molecule; and
(S3) administering the complex into a subject or cells in need thereof,
wherein the cell penetrating peptide consists of an amino acid sequence represented by General Formula below:
R1-R2-R3-R4-R5-R6-R7-R8-R9-R10-R11-R12-R13-R14,
wherein in General Formula, R14 is arginine (R), proline (P), lysine (K), or isoleucine (I);
at least one of R1 to R14 is proline (P);
when arginine (R) is assigned 1 point and lysine (K) is assigned 0.5 points
among R1 to R14, the sum of the peptide is 6.5 points or more;
the peptide includes one or more amino acids selected from the group consisting of valine (V), leucine (L), and isoleucine (I); and
wherein the cell penetrating peptide consists of any one amino acid sequence selected from the group consisting of SEQ ID NOs: 1 to 53.