Patent ID: 11964024
Assignee: MERSANA THERAPEUTICS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 9:
10. The B7-H4 antibody-drug conjugate of claim 9, comprising one or more Linker-Drug moieties covalently linked to the antibody, wherein:
each Linker-Drug moiety comprises a Multifunctional Linker that connects the antibody to one or more Drug Units through intermediacy of a Releasable Assembly Unit for each Drug Unit, and connects a hydrophilic group to the Drug Unit of each Linker-Drug moiety;
the Releasable Assembly unit is capable of releasing free drug in proximity to a target site targeted by the antibody; and
the Multifunctional Linker comprises a peptide moiety between the antibody and the hydrophilic group, wherein the peptide moiety comprises at least two amino acids.