Patent ID: 11939388
Assignee: BIONTECH SE
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A  G | IPC A  C  G

Claim 0:
1. A nucleic acid or a set of nucleic acids encoding a multispecific antibody, the multispecific antibody comprising:
(I) a first binding arm comprising a first antigen-binding region binding to human CD40, wherein said first antigen-binding region comprises heavy (VH) and light (VL) chain variable region CDR1, CDR2, and CDR3, heavy chain variable region CDR1, CDR2, and CDR3 having the amino acid sequences set forth in SEQ ID NOs:1, 2 and 3, respectively, and light chain variable region CDR1, CDR2 and CDR3 having the amino acid sequences set forth in SEQ ID NOs:4, YTS and 5, respectively; and
(II) a second binding arm comprising a second antigen-binding region binding to human CD137 comprising:
(i) a heavy and light chain variable region CDR1, CDR2, and CDR3, heavy chain variable region CDR1, CDR2, and CDR3 having the sequences set forth in SEQ ID NOs:64, 65 and 66, respectively, and light chain variable region CDR1, CDR2, and CDR3 having the sequences set forth in SEQ ID NO:67, GAS, and SEQ ID NO:68, respectively.