Patent ID: 11865183
Assignee: POLYTHERICS LIMITED
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 0:
1. A conjugate comprising a protein or peptide conjugated to a therapeutic agent via a linker, characterised in that the linker includes a unit of the formula ˜(CH2—CH2—O—)x˜ within a ring, in which x is a number from 2 to 50, said ring being attached via a single tethering atom within the ring to the rest of the linker, or said ring being attached via two tethering atoms within the ring to the rest of the linker at a single point, wherein the conjugate is formed from conjugation of said protein or peptide with a reagent represented schematically by the formula:, in which:
D represents said therapeutic agent;
each T independently represents a tethering atom in the ring;
PEG represents said unit of the formula ˜(CH2—CH2—O—)x˜ within a ring, in which x is a number from 2 to 50; and
F represents a functional group for bonding to said protein or peptide wherein the functional group is a maleimide or derivative thereof according to one of the following formulae:, , wherein the nitrogen atom of the maleimide ring is connected to the linker and L represents a leaving group.