Patent ID: 11897891
Assignee: INCYTE CORPORATION
Field: Organic fine chemistry (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 37:
38. The compound of claim 1, having Formula (IB):, , or a pharmaceutically acceptable salt thereof, wherein:
Z is CR6;
Cy1 is selected from C6-10 aryl and 5-10 membered heteroaryl; wherein each 5-10 membered heteroaryl has at least one ring-forming carbon atom and 1, 2, 3, or 4 ring-forming heteroatoms independently selected from N, O, and S; wherein a ring-forming carbon atom of 5-10 membered heteroaryl is optionally substituted by oxo to form a carbonyl group; and wherein the C6-10 aryl and 5-10 membered heteroaryl are each optionally substituted with 1 or 2 substituents independently selected from R10;
CyA is selected from C3-10 cycloalkyl, and C6-10 aryl; wherein the C3-10 cycloalkyl, and C6-10 aryl are each optionally substituted with 1, 2, or 3 substituents independently selected from R20;
R1 is independently selected from H, D, C1-6 alkyl, C1-6 haloalkyl halo, CN, ORa9, and NRc9Rd9;
R2 and R3 are each independently selected from H, D, and C1-6 alkyl;
R6 are each independently selected from H, D, C1-6 alkyl, C1-6 haloalkyl halo, CN, ORa9, and NRc9Rd9;
R4 is selected from H, D, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-10 cycloalkyl, 4-10 membered heterocycloalkyl, C6-10 aryl, 5-10 membered heteroaryl, halo, CN, ORa7 and NRc7Rd7; wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, 4-10 membered heterocycloalkyl, C6-10 aryl, and 5-10 membered heteroaryl, are each optionally substituted with 1 or 2 substituents independently selected from R40;
each R10 is independently selected from C1-6 alkyl, C1-6 haloalkyl, C3-10 cycloalkyl, 4-10 membered heterocycloalkyl, C6-10 aryl, and 5-10 membered heteroaryl, halo, D, CN, ORa1, and NRc1Rd1; wherein said C1-6 alkyl, C3-10 cycloalkyl, 4-10 membered heterocycloalkyl, C6-10 aryl, and 5-10 membered heteroaryl, are each optionally substituted with 1, 2 or 3 substituents independently selected from R11;
each R11 is independently selected from C1-6 alkyl, C1-6 haloalkyl, 4-10 membered heterocycloalkyl, C6-10 aryl, halo, D, CN, ORa3, C(O)Rb3, C(O)NRc3Rd3, C(O)ORa3, NRc3Rd3, NRc3C(O)Rb3, NRc3C(O)NRc3Rd3, S(O)2Rb3, and S(O)2NRc3Rd3; wherein said C1-6 alkyl and C6-10 aryl, are each optionally substituted with 1 or 2 substituents independently selected from R12;
each R12 is independently selected from C1-6 alkyl, C1-6 haloalkyl, 5-6 membered heteroaryl, halo, D, CN, ORa5, C(O)Rb5, C(O)NRc5Rd5, C(O)ORa5, and NRc5Rd5;
each R20 is independently selected from C1-6 alkyl, C1-6 haloalkyl, halo, D, CN, ORa2, C(O)Rb2, C(O)NRc2Rd2, C(O)ORa2, NRc2Rd2, and NRc2C(O)Rb2; wherein said C1-6 alkyl, is optionally substituted with 1 or 2 substituents independently selected from R21;
each R21 is independently selected from C1-6 alkyl, C1-6 haloalkyl, halo, D, CN, ORa4, and NRc4Rd4;
each R40 is independently selected from C1-6 alkyl, C1-6 haloalkyl, halo, D, CN, ORa8, and NRc8Rd8;
each Ra1, Rc1 and Rd1 is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C3-10 cycloalkyl, and 4-10 membered heterocycloalkyl; wherein said C1-6 alkyl, C3-10 cycloalkyl, and 4-10 membered heterocycloalkyl, are each optionally substituted with 1 or 2 substituents independently selected from R11;
or any Rc1 and Rd1 attached to the same N atom, together with the N atom to which they are attached, form a 4-, 5-, or 6-membered heterocycloalkyl group optionally substituted with 1 or 2 substituents independently selected from R11;
each Ra2, Rc2 and Rd2, is independently selected from H, C1-6 alkyl, and C1-6 haloalkyl; wherein said C1-6 alkyl, is optionally substituted with 1 or 2 substituents independently selected from R21;
each Rb2 is independently selected from C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C1-6 haloalkyl; wherein said C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, are each optionally substituted with 1 or 2 substituents independently selected from R21;
each Ra3, Rc3 and Rd3, is independently selected from H, C1-6 alkyl, and C1-6 haloalkyl; wherein said C1-6 alkyl is optionally substituted with 1 or 2 substituents independently selected from R12;
or any Rc3 and Rd3 attached to the same N atom, together with the N atom to which they are attached, form a 4-, 5-, or 6-membered heterocycloalkyl group optionally substituted with 1 or 2 substituents independently selected from R12;
each Rb3 is independently selected from C1-6 alkyl, C1-6 haloalkyl, C3-6 cycloalkyl, phenyl, 5-6 membered heteroaryl and 4-7 membered heterocycloalkyl; wherein said C1-6 alkyl, C3-6 cycloalkyl, phenyl, 5-6 membered heteroaryl and 4-7 membered heterocycloalkyl, are each optionally substituted with 1 or 2 substituents independently selected from R12;
each Ra4, Rc4 and Rd4, is independently selected from H, C1-6 alkyl, and C1-6 haloalkyl;
each Ra5, Rc5 and Rd5, is independently selected from H, C1-6 alkyl, and C1-6 haloalkyl;
each Rb5 is independently selected from C1-6 alkyl, and C1-6 haloalkyl;
each Ra7, Rc7, and Rd7 is independently selected from H, C1-6 alkyl, and C1-6 haloalkyl; wherein said C1-6 alkyl, is optionally substituted with 1 or 2 substituents independently selected from R40;
each Ra8, Rc8 and Rd8, is independently selected from H, C1-6 alkyl, and C1-6 haloalkyl; and
each Ra9, Rc9, and Rd9 is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C3-10 cycloalkyl, and 4-10 membered heterocycloalkyl;
or any Rc9 and Rd9 attached to the same N atom, together with the N atom to which they are attached, form a 4-, 5- or 6-membered heterocycloalkyl group.