Patent ID: 11919887
Assignee: VERTEX PHARMACEUTICALS INCORPORATED
Field: Organic fine chemistry (Chemistry)
Classification: CPC C  A | IPC C

Claim 0:
1. A compound of formula (I), or a pharmaceutically acceptable salt thereof, wherein:
X2a C—R2a;
X4a C—R4a;
X5a C—R5a;
X6a C—R6a;
each R is independently H or C1-C6 alkyl;
R2a, R4a, R5a, and R6a are each independently H, halo, C1-C6 alkyl, or C1-C6 haloalkyl;
R4b1 and R4b2 are each independently H, C1-C6 alkyl, C3-C6 cycloalkyl, or C1-C6 haloalkyl;
R5b1 and R5b2 are each independently H, C1-C6 alkyl, C3-C6 cycloalkyl, or C1-C6 haloalkyl;
X3c is N or C—R3c;
X4c is N or C—R4c;
X5c is N or C—R5c;
X6c is N or C—R6c;
R2c is H, OH, halo, C1-C6 alkyl, C2-C6 alkenyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, or -L1-L2-(C3-C6 cycloalkyl), wherein said cycloalkyl of R2c is optionally substituted with 1-2 halo;
L1 is a bond or O;
L2 is a bond or C1-C6 alkylene;
R3c is H, halo, C1-C6 alkyl, or C1-C6 haloalkyl;
R4c is H, halo, C1-C6 alkyl, or C1-C6 haloalkyl;
R5c is H, halo, C1-C6 alkyl, or C1-C6 haloalkyl; and
R6c is H, halo, C1-C6 alkyl, or C1-C6 haloalkyl; and
provided that no more than one of X3c, X4c, X5c, and X6c are N.