Patent ID: 11897968
Assignee: ALECTOR LLC
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. An isolated antibody that binds to human MerTK, wherein the antibody comprises an HVR-H1, HVR-H2, HVR-H3, HVR-L1, HVR-L2, and HVR-L3 comprising the amino acid sequences of:
(i) SEQ ID NOs: 75, 99, 125, 158, 187, and 207, respectively;
(ii) SEQ ID NOs: 76, 100, 126, 159, 187, and 208, respectively;
(iii) SEQ ID NOs: 77, 101, 127, 160, 188, and 209, respectively;
(iv) SEQ ID NOs: 75, 99, 128, 158, 187, and 210, respectively;
(v) SEQ ID NOs: 78, 102, 129, 161, 189, and 211, respectively;
(vi) SEQ ID NOs: 75, 103, 130, 158, 187, and 212, respectively;
(vii) SEQ ID NOs: 77, 101, 127, 162, 188, and 209, respectively;
(viii) SEQ ID NOs: 75, 99, 131, 163, 187, and 213, respectively;
(ix) SEQ ID NOs: 79, 104, 132, 164, 190, and 214, respectively;
(x) SEQ ID NOs: 80, 105, 133, 165, 191, and 215, respectively;
(xi) SEQ ID NOs: 81, 106, 134, 166, 192, and 216, respectively;
(xii) SEQ ID NOs: 82, 107, 135, 167, 193, and 217, respectively;
(xiii) SEQ ID NOs: 77, 108, 136, 167, 194, and 209, respectively;
(xiv) SEQ ID NOs: 75, 109, 137, 168, 187, and 218, respectively;
(xv) SEQ ID NOs: 83, 99, 138, 158, 187, and 210, respectively;
(xvi) SEQ ID NOs: 84, 99, 139, 169, 195, and 219, respectively;
(xvii) SEQ ID NOs: 85, 99, 140, 170, 196, and 220, respectively;
(xviii) SEQ ID NOs: 86, 99, 141, 171, 191, and 221, respectively;
(xix) SEQ ID NOs:87, 110, 142, 172, 197, and 222, respectively;
(xx) SEQ ID NOs: 88, 99, 143, 173, 191, and 223, respectively;
(xxi) SEQ ID NOs: 89, 111, 143, 173, 198, and 221, respectively;
(xxii) SEQ ID NOs: 90, 112, 144, 174, 199, and 224, respectively;
(xxiii) SEQ ID NOs: 91, 113, 145, 175, 200, and 225, respectively;
(xxiv) SEQ ID NOs: 90, 114, 146, 176, 201, and 226, respectively;
(xxv) SEQ ID NOs: 92, 115, 147, 177, 195, and 227, respectively;
(xxvi) SEQ ID NOs: 93, 116, 148, 178, 188, and 209, respectively;
(xxvii) SEQ ID NOs: 94, 117, 149, 179, 195, and 228, respectively;
(xxviii) SEQ ID NOs: 95, 118, 150, 180, 187, and 229, respectively;
(xxix) SEQ ID NOs: 95, 119, 151, 181, 187, and 208, respectively;
(xxx) SEQ ID NOs: 90, 120, 152, 182, 202, and 230, respectively;
(xxxi) SEQ ID NOs: 96, 118, 153, 183, 202, and 230, respectively;
(xxxii) SEQ ID NOs: 96, 121, 154, 181, 187, and 210, respectively;
(xxxiii) SEQ ID NOs: 90, 122, 155, 184, 203, and 231, respectively;
(xxxiv) SEQ ID NOs: 90, 122, 155, 184, 203, and 231, respectively;
(xxxv) SEQ ID NOs:97, 123, 156, 185, 204, and 232, respectively;
(xxxvi) SEQ ID NOs: 98, 124, 157, 186, 205, and 233, respectively;
(xxxvii) SEQ ID NOs: 83, 329, 334, 158, 187, and 210, respectively;
(xxxviii) SEQ ID NOs: 83, 330, 138, 158, 187, and 210, respectively;
(xxxix) SEQ ID NOs: 83, 329, 138, 340, 187, and 210, respectively;
(xl) SEQ ID NOs: 83, 329, 138, 341, 187, and 210, respectively;
(xli) SEQ ID NOs: 83, 329, 335, 341, 187, and 210, respectively;
(xlii) SEQ ID NOs: 83, 331, 138, 341, 187, and 210, respectively;
(xliii) SEQ ID NOs: 83, 329, 138, 342, 187, and 210, respectively;
(xliv) SEQ ID NOs: 83, 329, 336, 341, 187, and 210, respectively;
(xlv) SEQ ID NOs: 83, 329, 337, 343, 187, and 210, respectively;
(xlvi) SEQ ID NOs: 83, 332, 338, 341, 187, and 210, respectively;
(xlvii) SEQ ID NOs: 83, 333, 334, 158, 187, and 210, respectively;
(xlviii) SEQ ID NOs: 83, 332, 336, 341, 187, and 210, respectively;
(xlix) SEQ ID NOs: 83, 329, 339, 344, 187, and 210, respectively;
(l) SEQ ID NOs: 83, 329, 138, 158, 187, and 210, respectively;
(li) SEQ ID NOs: 84, 329, 139, 169, 195, and 219, respectively;
(lii) SEQ ID NOs: 84, 99, 139, 345, 195, and 219, respectively;
(liii) SEQ ID NOs: 346, 348, 355, 341, 187, and 360, respectively;
(liv) SEQ ID NOs: 95, 119, 355, 341, 187, and 361, respectively;
(lv) SEQ ID NOs: 95, 349, 356, 341, 187, and 362, respectively;
(lvi) SEQ ID NOs: 95, 119, 356, 341, 359, and 362, respectively;
(lvii) SEQ ID NOs: 346, 119, 356, 341, 359, and 362, respectively;
(lviii) SEQ ID NOs: 95, 350, 356, 341, 359, and 362, respectively;
(lix) SEQ ID NOs: 95, 351, 356, 341, 359, and 362, respectively;
(lx) SEQ ID NOs: 347, 119, 356, 341, 359, and 362, respectively;
(lxi) SEQ ID NOs: 346, 119, 356, 341, 359, and 362, respectively;
(lxii) SEQ ID NOs: 95, 119, 356, 341, 187, and 362, respectively;
(lxiii) SEQ ID NOs: 95, 352, 356, 341, 187, and 362, respectively;
(lxiv) SEQ ID NOs: 95, 350, 356, 341, 359, and 362, respectively;
(lxv) SEQ ID NOs: 95, 353, 356, 341, 359, and 362, respectively;
(lxvi) SEQ ID NOs: 95, 351, 356, 341, 359, and 362, respectively;
(lxvii) SEQ ID NOs: 95, 350, 356, 341, 359, and 362, respectively;
(lxviii) SEQ ID NOs: 346, 354, 356, 341, 359, and 363, respectively;
(lxix) SEQ ID NOs: 346, 348, 356, 357, 359, and 362, respectively;
(lxx) SEQ ID NOs: 346, 354, 356, 358, 187, and 362, respectively;
(lxxi) SEQ ID NOs: 95, 348, 151, 181, 187, and 208, respectively;
(lxxii) SEQ ID NOs: 90, 364, 373, 376, 388, and 231, respectively;
(lxxiii) SEQ ID NOs: 90, 364, 155, 377, 203, and 231, respectively;
(lxxiv) SEQ ID NOs: 90, 364, 374, 378, 203, and 231, respectively;
(lxxv) SEQ ID NOs: 90, 365, 155, 376, 203, and 392, respectively;
(lxxvi) SEQ ID NOs: 90, 364, 155, 376, 389, and 231, respectively;
(lxxvii) SEQ ID NOs: 90, 364, 155, 379, 203, and 231, respectively;
(lxxviii) SEQ ID NOs: 90, 366, 155, 380, 203, and 231, respectively;
(lxxix) SEQ ID NOs: 90, 364, 373, 381, 203, and 231, respectively;
(lxxx) SEQ ID NOs: 90, 367, 155, 382, 203, and 231, respectively;
(lxxxi) SEQ ID NOs: 90, 368, 155, 383, 203, and 231, respectively;
(lxxxii) SEQ ID NOs: 90, 364, 374, 384, 203, and 231, respectively;
(lxxxiii) SEQ ID NOs: 90, 368, 155, 376, 203, and 293, respectively;
(lxxxiv) SEQ ID NOs: 90, 364, 155, 378, 203, and 231, respectively;
(lxxxv) SEQ ID NOs: 90, 368, 155, 376, 203, and 231, respectively;
(lxxxvi) SEQ ID NOs: 90, 369, 155, 378, 203, and 394, respectively;
(lxxxvii) SEQ ID NOs: 90, 364, 155, 378, 203, and 231, respectively;
(lxxxviii) SEQ ID NOs: 90, 370, 155, 378, 203, and 394, respectively;
(lxxxix) SEQ ID NOs: 90, 371, 155, 378, 203, and 394, respectively;
(xc) SEQ ID NOs: 90, 368, 155, 385, 203, and 394, respectively;
(xci) SEQ ID NOs: 90, 368, 155, 378, 203, and 395, respectively;
(xcii) SEQ ID NOs: 90, 368, 155, 378, 390, and 394, respectively;
(xciii) SEQ ID NOs: 90, 372, 155, 378, 391, and 394, respectively;
(xciv) SEQ ID NOs: 90, 368, 375, 386, 203, and 394, respectively; or
(xcv) SEQ ID NOs: 90, 368, 155, 387, 203, and 394, respectively.