Patent ID: 11877999
Assignee: THE TRUSTEES OF INDIANA UNIVERSITY
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 0:
1. A compound that forms a covalent bond with a cysteine residue within an E6AP binding pocket in human papilloma virus (HPV) E6 protein, thereby preventing binding of the E6 protein to an E6AP protein, wherein said compound has the general structure of, wherein
R32 and R33 together with the atoms to which they are bound form a cyclic or bicyclic ring selected from the group consisting of, n is an integer selected from 0-4;
m is 0 or 1;
X and Y are independently N or C;
R34 is H, —OCH3, or —OCF3;
R35 is H, F, or —OCH3,
R36 is selected from the group consisting of H and CH3; and
R31 is selected from the group consisting of —CH=CH2, -CH=CHCH3, and —CH=CHCH2N(CH3)2.