Patent ID: 11931429
Assignee: RAMOT AT TEL-AVIV UNIVERSITY LTD.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C  Y | IPC A  C

Claim 4:
5. The conjugate of claim 1, wherein:
R1 is a linear or branched (C1-C8)alkyl;
R2 and R3 together with the carbon atom to which they are attached form a fused, spiro or bridged polycyclic ring;
at least one of R7, R8 and R9 is H, and the other of R7, R8 and R9 each independently is an electron acceptor group selected from the group consisting of halogen, —NO2 and —CN; and
X is a linker of the formula —X1—X2—, wherein X1 is (C1-C18)alkylene, (C6-C14)arylene-diyl, or (C1-C18)alkylene-(C6-C14)arylene-diyl, optionally substituted by one or more groups each independently selected from the group consisting of halogen, —COH, —COOH, —OCOOH, —OCONH2, —CN, —NO2, —SH, —OH, —NH2, —CONH2, —SO2H, —SO3H, —S(═O)H, (C6-C10)aryl, (C1-C4)alkylene-(C6-C10)aryl, heteroaryl, and (C1-C4)alkylene-heteroaryl, and said (C1-C18)alkylene being further optionally interrupted by one or more identical or different heteroatoms selected from the group consisting of S, O and N, and/or at least one group each independently selected from the group consisting of —NH—CO—, —CO—NH—, —N(C1-C8alkyl)-, —N(C6-C10aryl)-, (C6-C10)arylene-diyl, and heteroarylenediyl; and X2 is —C(O)—.