Patent ID: 11970532
Assignee: NEURACLE SCIENCE CO., LTD.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 0:
1. An isolated antibody, or antigen-binding portion thereof, which specifically binds a human family with sequence similarity 19, member A5 (FAM19A5) protein (anti-FAM19A5 antibody), comprising a heavy chain CDR1, CDR2, and CDR3 and a light chain CDR1, CDR2, and CDR3, wherein:
(1) (i) the heavy chain CDR1 comprises the amino acid sequence set forth in SEQ ID NO: 5; (ii) the heavy chain CDR2 comprises the amino acid sequence set forth in SEQ ID NO: 6; (iii) the heavy chain CDR3 comprises the amino acid sequence set forth in SEQ ID NO: 7; (iv) the light chain CDR1 comprises the amino acid sequence set forth in SEQ ID NO: 13; (v) the light chain CDR2 comprises the amino acid sequence set forth in SEQ ID NO: 14; and (vi) the light chain CDR3 comprises the amino acid sequence set forth in SEQ ID NO: 10;
(2) (i) the heavy chain CDR1 comprises the amino acid sequence set forth in SEQ ID NO: 5; (ii) the heavy chain CDR2 comprises the amino acid sequence set forth in SEQ ID NO: 27; (iii) the heavy chain CDR3 comprises the amino acid sequence set forth in SEQ ID NO: 7; (iv) the light chain CDR1 comprises the amino acid sequence set forth in SEQ ID NO: 13; (v) the light chain CDR2 comprises the amino acid sequence set forth in SEQ ID NO: 29; and (vi) the light chain CDR3 comprises the amino acid sequence set forth in SEQ ID NO: 10; or
(3) (i) the heavy chain CDR1 comprises the amino acid sequence set forth in SEQ ID NO: 5; (ii) the heavy chain CDR2 comprises the amino acid sequence set forth in SEQ ID NO: 28; (iii) the heavy chain CDR3 comprises the amino acid sequence set forth in SEQ ID NO: 7; (iv) the light chain CDR1 comprises the amino acid sequence set forth in SEQ ID NO: 13; (v) the light chain CDR2 comprises the amino acid sequence set forth in SEQ ID NO: 29; and (vi) the light chain CDR3 comprises the amino acid sequence set forth in SEQ ID NO: 10.