Patent ID: 11964028
Assignee: UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C  B | IPC A  B  C

Claim 0:
1. A method of diagnosing cancer in a subject, the method comprising administering to the subject an RNA dendrimer molecule, wherein the RNA dendrimer molecule comprises (a) a central core multi-branched RNA junction motif, wherein the central core motif comprises a plurality of branches, wherein a branch comprises at least one RNA oligonucleotide, and wherein the central core motif comprises at least one RNA oligonucleotide having at least 90% identity to SEQ ID NO: 12 (SquareE); and (b) an outer surface multi-branched RNA junction motif comprising at least one repeating multi-branched RNA junction motif unit, wherein the repeating unit comprises a plurality of branches, and wherein a branch comprises at least one RNA oligonucleotide, wherein the RNA dendrimer molecule comprises at least one imaging module, wherein the RNA dendrimer molecule comprises a folate receptor targeting module, wherein the cancer comprises a cancer that overexpresses folate receptor, and diagnosing the subject as having cancer if the RNA dendrimer molecule is detected in the subject.