Patent ID: 11944689
Assignee: SEAGEN INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 12:
13. The Ligand Drug Conjugate compound of claim 12 wherein the quaternized tubulysin Drug Unit —D+ has the structure of:, in pharmaceutically acceptable salt form, wherein
R3 is —CH3 or —CH2CH2CH3;
R2B is —CH3, —CH2CH3, —CH2CH2CH3, —CH(CH3)2, —CH2CH(CH3)2, —CH2C(CH3)3, or wherein the quaternized tubulysin Drug Unit —D+ has the structure of:, in pharmaceutically acceptable salt form, wherein
R2B is —H, methyl, ethyl, vinyl or —C(═CH2)CH3.