Patent ID: 11951129
Assignee: H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 3:
4. The polypeptide of claim 1, wherein the CAR polypeptide is defined by the formula:

SP-CLEC12A-HG-TM-CSR-ISD; or

SP-CLEC12A-HG-TM-ISD-CSR

wherein “SP” represents a signal peptide,
wherein “CLEC12A” represents a CLEC12A-binding region,
wherein “HG” represents and optional hinge domain,
wherein “TM” represents a transmembrane domain,
wherein “CSR” represents a co-stimulatory signaling region,
wherein “ISD” represents an intracellular signaling domain, and wherein “—” represents a bivalent linker.