Patent ID: 11872304
Assignee: OTSUKA PHARMACEUTICAL FACTORY, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 12:
13. A method for suppressing separation and coloration in a topical composition containing (A) 30% to 60% by weight of zinc chloride and (D) solvent, comprising,
in the topical composition, blending (B) inorganic powder and (C) additive together with the component (A) and the component (D),
wherein the component (C) is (c1) a cellulous derivative in which a hydroxyl group of cellulose is substituted with a substituent selected from the group consisting of —OR1 group, —OR2OH group, —OR3OR4 group, and —OCOR5 group wherein R1 represents an alkyl group having 1 to 3 carbon atoms, R2 represents an alkylene group having 2 to 3 carbon atoms, R3 represents an alkylene group having 1 to 3 carbon atoms, R4 represents an alkyl group having 1 to 3 carbon atoms, and R5 represents an organic group; (c2) a polyvinyl-type alcohol selected from the group consisting of polyvinyl alcohol and a derivative thereof; or (c3) polyoxyethylene polyoxypropylene glycol,
wherein the component (B) is selected from the group consisting of silicon dioxide, aluminum silicate, magnesium silicate, magnesium aluminum silicate, sodium magnesium silicate, calcium silicate, talc, calamine, zinc oxide, titanium oxide, iron oxide, aluminum hydroxide, calcium phosphate, and magnesium phosphate, and
wherein a weight ratio of the component (B) is 9 parts by weight to 60 parts by weight based on 100 parts by weight of the component (A), and a weight ratio of the component (C) is 0.1 parts by weight to 13 parts by weight based on 100 parts by weight of the component (A).