Patent ID: 11932872
Assignee: NANJING ANJI BIOLOGICAL TECHNOLOGY CO., LTD
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC C

Claim 0:
1. A switchable dual chimeric antigen receptor T cell, wherein the dual chimeric antigen receptor consists of a first chimeric antigen receptor for MSLN and a second chimeric antigen receptor for FITC; the dual chimeric antigen receptor contains a blue fluorescent protein tag downstream, and a linker peptide P2A is contained between the dual chimeric antigen receptor and the fluorescent protein tag;
wherein a molecular switch is provided in the form of FITC coupled to polypeptide HM-3, wherein the FITC and polypeptide HM-3 are coupled to form a bifunctional specific small molecule drug, and the amino acid sequence of the polypeptide HM-3 is Ile-Val-Arg-ArgAla-Asp-Arg-Ala-Ala-Val-Pro-Gly-Gly-Gly-Gly-Arg-Gly-Asp (SEQ ID NO: 18); and
the nucleotide sequence of the dual chimeric antigen receptor as shown in SEQ ID NO: 1.