Patent ID: 11878173
Assignee: DUKE UNIVERSITY
Field: Medical technology (Instruments)
Classification: CPC A | IPC A

Claim 5:
6. A method for stimulation of a targeted neurological tissue region comprising:
applying electrical current to a targeted neurological tissue region in a brain of an animal using an implantable pulse generator operatively coupled with at least one electrode, wherein the electrical current comprises a first non-regular pulse train comprising a plurality of pulses having differing inter-pulse intervals between the pulses;
applying a model-based optimization technique creating a subsequent non-regular pulse train comprising a plurality of second pulses having non-regular inter-pulse intervals between the second pulses wherein the subsequent non-regular pulse train is different from the first non-regular pulse train; and
applying electrical current to the targeted neurological tissue region of the animal using the pulse generator according to the subsequent non-regular pulse train in succession.