Patent ID: 11958890
Assignee: LYSANDO AG
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 2:
3. The polypeptide according to claim 1, wherein the peptide comprises a sequence motif which:
i) is 16, 17, 18, 19 or 20 amino acids in length;
ii) comprises at least 40% and at most 60% amino acids selected from a first group of amino acids consisting of lysine, arginine and histidine,
wherein each amino acid of said at least 40% and at most 60% amino acids is selected independently from said first group,
wherein each amino acid selected from this first group is arranged in said sequence motif either alone, pairwise together with a further amino acid selected from the first group, or in a row with 2 further amino acids selected from the first group, but does not occur in a row with 3 or more further amino acids selected from the first group, wherein at least 2 pairs of amino acids selected from the first group are present in said sequence motif, and wherein at most one row with 3 of the amino acids selected from the first group is present in said sequence motif, with the additional proviso, that if such row with 3 amino acids of the first group is present in said sequence motif, then the amino acids at positions −12, −11, −8, −5, −4, +6, +7, +10, +13, and +14 relative to the first amino acid of the 3 amino acids in a row are, provided the respective position exists in said sequence motif, not selected from said first group;

iii) comprises at least 40% and at most 60% amino acids selected from a second group of amino acids consisting of alanine, glycine, isoleucine, leucine, phenylalanine, serine, threonine, tryptophan, tyrosine and valine;
wherein each amino acid of said at least 40% and at most 60% amino acids selected from the second group is selected independently from said second group; and

iv) wherein the remaining amino acids of said sequence motif, if any are present in the motif, are selected from a third group consisting of asparagine, aspartic acid, glutamine, glutamic acid, methionine, and cysteine, wherein each of said amino acids is selected independently from said third group.