Patent ID: 11883469
Assignee: UNIVERSITY OF THE WITWATERSRAND, JOHANNESBURG
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 3:
4. The method of claim 1, wherein the pharmaceutical composition is produced by the following steps:
(i) dissolving elastin (E) and collagen (C) in an acidic aqueous medium to form a first solution;
(ii) adding acrylonitrile to the first solution and mixing to form a second solution, which second solution is agitated/mixed until homogenous;
(iii) adding an initiator to the homogenous second solution, wherein the initiator initiates free radical polymerization of the acrylonitrile to form an interpenetrating polyacrylonitrile (PANi), elastin (E) and collagen (C) polymer network (iPANi-E-C); and
(iv) adding a crosslinking agent,, wherein the crosslinking agent crosslinks the polyacrylonitrile (PANi) to form a crosslinked, porous, interpenetrating polyacrylonitrile (PANi), elastin (E) and collagen (C) polymer network (xpi-PANi-E-C), and wherein the method facilitates and provides for the reorientated secondary structure of the elastin (E) and collagen (C) proteins.