Patent ID: 11872313
Assignee: nan
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  Y | IPC A

Claim 0:
1. A composition for in vivo delivery of a compound into a target cell, the composition comprising a non-liposomal particle having
an outer surface that is a membrane comprising at least one prodrug, about 100 mol % to about 60 mol % phospholipid, and a homing ligand, wherein the prodrug comprises a compound of less than about 3000 da linked to an acyl moiety of a phosphoglyceride, and the compound may be released from the phosphoglyceride backbone via enzyme cleavage; and
an inner core;, wherein, in vivo, the particle substantially retains the prodrug within the membrane of the particle until the particle fuses with the target cell's membrane and transfers the prodrug from the particle to the target cell membrane, and wherein particle can leave blood vessels while circulating through the body; and
wherein the particle is sized less than 20 nm.