Patent ID: 11969293
Assignee: UNIVERSITY OF SOUTH CAROLINA
Field: Medical technology (Instruments)
Classification: CPC A  G | IPC A  G

Claim 0:
1. A method for analyzing passive left ventricular myocardial stiffness comprising:
measuring regional left ventricular geometry;
measuring myocardial strain;
estimating a ventricular pressure within an inverse finite-element analysis;
computing regional left ventricular myocardial mechanical properties;
generating a spatiotemporal map to visualize a heterogeneous two-dimensional distribution of at least one mechanical property across a left ventricle and display both radial and longitudinal end-diastolic wall stress;
wherein an objective function in the form of, Π
     
       
  
   (
   
    
     
      
       A
       ′
      
      -
      A
     
     A
    
    +
    
     
      ∑
      
       i
       =
       1
      
      6
     
     
      (
      
       
        
         ε
         i
         ′
        
        -
        
         ε
         i
        
       
       
        ε
        i
       
      
      )
     
    
    +
    
     
      
       
        t
        ′
       
       _
      
      -
      
       t
       _
      
     
     
      t
      _
     
    
   
   )
  
  ×
  100
  ⁢
  %
 

is developed as a function of, at least, actual end-diastolic area (A), regional strain (εi) relative to a reference mesh, and mean wall thickness (t) determined from an end-diastolic mesh; and
wherein the spatiotemporal map in conjunction with the objective function quantify passive left ventricle myocardium stiffness in a subject.