Patent ID: 11911446
Assignee: BIOMARIN PHARMACEUTICAL INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 0:
1. A method of increasing long bone growth in a subject in need thereof, said method comprising the step of administering to said subject a composition comprising:
(a) a CNP variant peptide in an amount of at least 7.5 μg/kg, wherein the CNP variant peptide is selected from the group consisting of:, (CNP-37(M32N); SEQ ID NO: 1)

QEHPNARKYKGANKKGLSKGCFGLKLDRIGSNSGLGC;

 

(Met-CNP-37; SEQ ID NO: 2)

MQEHPNARKYKGANKKGLSKGCFGLKLDRIGSMSGLGC;

 

(Pro-CNP-37; SEQ ID NO: 3)

PQEHPNARKYKGANKKGLSKGCFGLKLDRIGSMSGLGC;

 

(Gly-CNP 37 (M32N); SEQ ID NO: 4)

GQEHPNARKYKGANKKGLSKGCFGLKLDRIGSNSGLGC;

 

(Pro-Gly-CNP-37; SEQ ID NO: 5)

PGQEHPNARKYKGANKKGLSKGCFGLKLDRIGSMSGLGC;

 

(Met-Gly-CNP-37; SEQ ID NO: 6)

MGQEHPNARKYKGANKKGLSKGCFGLKLDRIGSMSGLGC;

and

 

(Gly-CNP-37 or CNP-28: SEQ ID NO: 7)

GQEHPNARKYKGANKKGLSKGCFGLKLDRIGSMSGLGC,

 and
(b) citric acid monohydrate, sodium citrate dihydrate, trehalose dihydrate, D-mannitol, L-methionine and polysorbate 80,
wherein said step of administering increases long bone growth in said subject.