Patent ID: 11911521
Assignee: UNIVERSITY OF MANITOBA
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  D  B | IPC A  B  D

Claim 0:
1. A core-shell nanofiber comprising:
a core comprising an antibacterial agent and a biocompatible polymer; and
a shell surrounding said core, said shell comprising a bacterially degradable polymer,
wherein said biocompatible polymer comprises poly(vinylpyrrolidone) (PVP),
wherein said bacterially degradable polymer of said shell comprises polycaprolactone (PCL) and poly(ethylene succinate) (PES) wherein the shell has been formed by electrospinning a solution of 8% by weight PCL and a solution of 20% by weight PES at a PCL solution to PES solution volume ratio of from 5:1 to 1:5 or 1:1 for controlled degradation rate of said shell when exposed to a bacterial enzyme, said degradation rate of said shell being controllable by adjusting said PCL to PES volume ratio and adaptable to degrade within 2 hours of exposure to said enzyme,
wherein core to shell ratio by weight in said core-shell nanofiber is in the range of 1:5 to 5:1, or within the range of 1:2 to 2:1,
wherein the antibacterial agent is present in the core at 1% to 10% by weight or 2% to 5% by weight,
wherein when said nanofiber is applied to a wound release of said antibacterial agent is dependent on degradation of said shell when exposed to said enzyme, and dissolution of said biocompatible polymer in the core is limited to areas corresponding to enzyme exposure points on the shell, and
wherein said enzyme is lipase secreted by both Gram-positive and Gram-negative bacteria.