Patent ID: 11918352
Assignee: ISBRG CORP.
Field: Medical technology (Instruments)
Classification: CPC A | IPC A

Claim 9:
10. A method of non-invasively determining a physiological state of interest of a subject comprising,
(a) determining at least one physiological parameter of the subject;
(b) placing a body part in contact with a receptor;
(c) directing a source of electromagnetic radiation (EMR) over a range of wavelengths through the receptor and onto the body part so that the EMR reaches the blood and interstitial fluid within the body part;
(d) measuring the EMR absorbed by, reflected by, or transmitted through, the blood and interstitial fluid of the body part with a detector to obtain a spectrum over the range of wavelengths;
(e) performing a quantitative mathematical analysis of the spectrum using an algorithm to determine an amount of at least one known analyte within the blood and interstitial fluid of the body part, wherein the at least one known analyte is
selected from the group consisting of: delta-9-tetrahydrocannabinol (THC), THC glucuronide (THCGlu), 11-nor-9-carboxy-THC (THC-COOH), 11-hydroxy THC (11-OH-THC), THC-COOH/11-OH-THC ratio, 11-nor-9-carboxy-THC glucuronide (THC-COOGlu), cannabidol (CBD), cannbinol (CBN), cannabigerol (CBG), delta-9-tetrahydrocannabivarin (THCV), THCV-carboxylic acid, 11-nor-9-carboxy-delta—tetrahydrocannabivarin (THCV-COOH), albumin, apolipoproteins A1 and B (apoA1 and apoB), total protein, bilirubin, prolactin, triglycerides, creatinine, cortisol, glucose, lactate, Total 4, uric acid, blood urea nitrogen (BUN), blood sugar, calcium, ionized calcium, magnesium, sodium, phosphate, GABA, alcohol, aldehyde, and lactic acid;

(f) deriving a biochemical profile from the amount of the at least one known analyte and from the spectrum corresponding to multiple ghost analytes whose identities are unknown and that are observed to change in response to the physiological state of interest, wherein the state of interest is impairment or intoxication of the subject; and
(g) analyzing the biochemical profile and the at least one physiological parameter used to determine the physiological state of interest in the subject.