Patent ID: 11898055
Assignee: UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
Field: Medical technology (Instruments)
Classification: CPC C  A  B | IPC A  B  C

Claim 10:
11. A method of preparing a coating medical implant device, comprising:
selecting a substrate from the group comprising magnesium metal, magnesium alloy, iron metal, iron alloy, ferrous metal and ferrous alloy;
applying a pretreatment agent selected from the group consisting of alkali metal hydroxide, hydrogen fluoride, alkali metal carbonates, and mixtures thereof, to a surface of the substrate to form a charged substrate having a positive charge or negative charge; and
depositing a plurality of interfacing, individual polymer layers on the charged substrate to form a polyelectrolyte multilayer coating, comprising:
depositing at least one polymer layer comprising a first polymer and having a positive charge; and
depositing at least one polymer layer comprising a second polymer and having a negative charge,

wherein an initial polymer layer of the plurality of interfacing, individual polymer layers is deposited on the charged substrate and has a charge opposite the charged substrate, and
wherein an outer polymer layer of the plurality of interfacing, individual polymer layers forms an exterior surface of the charged substrate;
immobilizing fibronectin on the exterior surface; and
depositing an active substance, in addition to the fibronectin, on the exterior surface of the charged substrate.