Patent ID: 11919970
Assignee: JUNO THERAPEUTICS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 28:
29. The anti-ROR1 antibody or antigen-binding fragment thereof of claim 23, wherein:
(a) the anti-ROR1 antibody or antigen-binding fragment thereof has a binding affinity for a human ROR1 protein that is equal to or higher than the binding affinity for the ROR1 protein of the corresponding form of the anti-ROR1 antibody R12 or antigen-binding fragment thereof;
(b) the anti-ROR1 antibody or antigen-binding fragment thereof specifically binds to the same or an overlapping epitope of a human ROR1 protein as the epitope specifically bound by the anti-ROR1 antibody R12 or an antigen-binding fragment thereof;
wherein the anti-ROR1 antibody R12 or antigen-binding fragment thereof comprises a VH region comprising the amino acid sequence set forth in SEQ ID NO: 85 and a VL region comprising the amino acid sequence set forth in SEQ ID NO: 86.