Patent ID: 11944424
Assignee: DUKE UNIVERSITY
Field: Measurement (Instruments)
Classification: CPC A  G | IPC A  G

Claim 26:
27. A medical evaluation system comprising a server in communication with at least one Magnetic Resonance Imaging (MRI) scanner and having at least one processor that carries out a method of generating spectroscopy parameters for medical evaluation of a subject, comprising:
obtaining a series of 129Xe free induction decays (FIDs) of a gas exchange region of a lung or lungs of the subject during a breathing maneuver;
fitting real and imaginary components of the FIDs in a time domain with a curve fitting function modeled with one or more non-Lorentzian line shapes, wherein the curve fitting function models each of a 129Xe barrier resonance, a 129Xe gas-phase resonance and a 129Xe red blood cell (RBC) resonance, with the 129Xe barrier resonance modeled, at least in part, with the one or more non-Lorentzian line shapes; and
electronically generating a plurality of 129Xe spectral parameters comprising RBC spectral parameters of RBC amplitude, RBC chemical shift (ppm), RBC full width at half maximum (FWHM) (ppm) and RBC phase (degrees) based on the fitting, wherein the plurality of 129Xe spectral parameters include static and dynamic 129Xe spectral parameters using plots over time of at least one of:
(i) barrier amplitude, barrier chemical shift (ppm), and one or more barrier FWHM (ppm) parameters; and
(ii) the RBC amplitude, the RBC chemical shift (ppm), the RBC FWHM (ppm), and the RBC phase (degrees),
wherein the static and dynamic 129Xe spectral parameters comprise RBC amplitude oscillations, RBC chemical shift oscillations, RBC FWHM oscillations and RBC phase oscillations, and
correcting peak-to-peak amplitude of the RBC amplitude oscillations based at least in part on an estimated pulmonary exchange volume of the subject;
wherein the method further comprises diagnosing a medical condition of the subject based on the static and dynamic 129Xe spectral parameters.