Patent ID: 11878989
Assignee: SHANGHAI FOREFRONT PHARMA CO., LTD.
Field: Organic fine chemistry (Chemistry)
Classification: CPC C  Y | IPC C

Claim 0:
1. A method for preparing an L-erythro biopterin compound, wherein the L-erythro biopterin compound has the structure shown in formula (I), and the L-erythro biopterin compound represented by formula (I) is prepared by dihydroxylation of the compound represented by formula (II) or the compound represented by formula (III);, wherein
Y is O or absent;
Z is a hydrogen atom or a leaving group;
R1 is a substituted or unsubstituted alkyl, a substituted or unsubstituted cycloalkyl, a substituted or unsubstituted heterocycloalkyl, a substituted or unsubstituted aryl, or a substituted or unsubstituted heteroaryl;
R2 and R3 are independently a hydrogen atom or an amino protecting group; and R2 and R3 together with the nitrogen atom connected to R2 and R3 can form a cyclic lactim group;
R4 is —COOR5, —CONR6 or —CN;
R5 and R6 are independently a hydrogen atom, a substituted or unsubstituted alkyl, a substituted or unsubstituted cycloalkyl, a substituted or unsubstituted heterocycloalkyl, a substituted or unsubstituted aryl, or a substituted or unsubstituted heteroaryl;
R7 is —OH or —NH2.