Patent ID: 11919972
Assignee: REGENERON PHARMACEUTICALS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  G  A | IPC A  C  G

Claim 23:
24. A method of imaging in vivo expression of a target, the method comprising:
(a) providing a cyclic peptide of claim 1, wherein SEQ is a peptide sequence having affinity for the target, and modifying the cyclic peptide to include a small-molecule positron-emission-tomography ligand (PET ligand);
(b) administering the cyclic peptide of step (a) to the subject;
(c) measuring the positron emission from the PET ligand at a first time;
(d) measuring the positron emission from the PET ligand at a second time; and
(e) comparing the positron emission from the PET ligand at the first and second times wherein the PET ligand comprises a moiety selected from 64Cu DOTA, 68Ga DOTA, 68Ga NOTA, 18F, 64Cu, 68Ga, 89Zr, 124I, 86Y, 94mTc, 110mIn, 11C, and 76Br.