Patent ID: 11911447
Assignee: MEDERIS DIABETES LLC
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C  Y | IPC A  C

Claim 3:
4. The peptide of claim 2, having the structure of Formula III-A, Formula III-A

aa1-aa2-aa3-aa4-aa5-aa6-aa7-aa8-aa9-aa10-aa11-

 

aa12-aa13-aa14-aa15-aa16-aa17-aa18-aa19-aa20-

 

aa21-aa22-aa23-aa24-aa25-aa26-aa27-aa28-aa29-Z

wherein:
Z is OH, or —NH-R3, wherein R3 is H, or C1-C12 substituted or unsubstituted alkyl;
aa1 is His;
aa2 is Aib;
aa3 is Gln;
aa4 is Gly;
aa5 is Thr;
aa6 is Phe;
aa7 is Thr;
aa8 is Ser;
aa9 is Asp;
aa10 is Tyr, Glu, or Lys;
aa11 is Ser;
aa12 is Lys or Glu;
aa13 is Tyr;
aa14 is Leu, Glu, or Lys;
aa15 is Asp;
aa16 is Glu or Lys;
aa17 is Lys;
aa18 is Ala;
aa19 is Ala;
aa20 is Lys, or Glu;
aa21 is Glu;
aa22 Phe;
aa23 is Ile;
aa24 is Gln, or Glu;
aa25 is Trp;
aa26 is Leu;
aa27 is Leu;
aa28 is Gln;
aa29 is Thr;
wherein aa16 and aa20, or aa10 and aa14, or aa12 and aa16 are optionally cyclized through their side chains to form a lactam linkage.