Patent ID: 11918706
Assignee: MEDPARK CO., LTD
Field: Medical technology (Instruments)
Classification: CPC A | IPC A

Claim 0:
1. A method for preparing a bone graft composition, the method comprising steps of:
preparing a bone morphogenetic protein solution by adding a bone morphogenetic protein to a solvent, or the bone morphogenetic protein to the solvent and dissolving the bone morphogenetic protein on the solvent;
adsorbing the bone morphogenetic protein onto previously prepared graft material powder by soaking the graft material powder with the bone morphogenetic protein solution through flushing of the graft material powder with the bone morphogenetic protein solution or dropping of the graft material powder into the bone morphogenetic protein solution;
mixing and stirring the graft material powder having the bone morphogenetic protein adsorbed thereon and hydroxypropyl methylcellulose powder to form a viscous gel;
wherein adsorbing the bone morphogenetic protein onto the graft material powder comprises a step of adsorbing the bone morphogenetic protein using a refrigerated centrifuge; and
forming a sponge-like structure containing a plurality of pores by freeze-drying the mixture of the graft material powder and the hydroxypropyl methylcellulose powder, obtained by the mixing and stirring process, at a low temperature under vacuum,
wherein the step of adsorbing the bone morphogenetic protein using the refrigerated centrifuge is performed at a cold temperature of 5° C. or below; and
wherein the volume ratio between the graft material powder having the bone morphogenetic protein adsorbed thereon and the hydroxypropyl methylcellulose powder is 1:0.25 to 1:0.35.