Patent ID: 11891451
Assignee: VIB VZW
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A nucleotide sequence encoding a polypeptide, wherein the polypeptide comprises:
an immunoglobulin single variable domain (ISVD) derived from a camelid heavy chain antibody, wherein the ISVD comprises an amino acid sequence that comprises 4 framework regions (FR) and 3 complementarity determining regions (CDR) according to the following formula (1):

FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4  (1),

wherein the ISVD further comprises a N-glycosylation acceptor site present on an amino acid selected from amino acids 83 to 88 of the ISVD according to the AHo numbering convention.