Patent ID: 11873282
Assignee: UNIVERSITY OF TENNESSE RESEARCH FOUNDATION
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A selective androgen receptor degrader (SARD) compound represented by the structure of formula XVII(1):, wherein
X1, X2, X3, X4, and X5 are each independently N or CH, wherein if any one of X1, X2, X3, X4, and X5 is CH, then the H is optionally replaced with R2, Y, or Z in the respective position, and if any one of X1, X2, X3, X4, and X5 is not CH, then the respective position is unsubstituted; wherein at least one of X1, X2, X3, X4, or X5 is nitrogen;
W1 and W2 are each independently selected from N or CH;
W3, W4, W5 and W6 are CH;
wherein if any one of W1, W2, W3, W4, W5, and W6 is CH, then the H is optionally replaced with R4, Q or R3 in the respective position, and if any one of W1, W2, W3, W4, W5, and W6 is not CH, then the respective position is unsubstituted;
T is OH, OR, —NHCOCH3, NHCOR or, Z is NO2, CN, or COOH;
Y is CF3, F, I, Br, Cl, CN or C(R)3;
R is alkyl, haloalkyl, dihaloalkyl, trihaloalkyl, CH2F, CHF2, CF3, CF2CF3, aryl, phenyl, F, Cl, Br, I, alkenyl or OH;
R1 is CH3, CH2F, CHF2, CF3, CH2CH3, or CF2CF3;
R2 is hydrogen, halogen, CN, NO2, COOH, COOR, COR, NHCOR, CONHR, OH, OR, SH, SR, NH2, NHR, NR2, C1-C12-alkyl, C1-C12-haloalkyl, O—C1-C12-alkyl, O—C1-C12-haloalkyl, —SO2-aryl, —SO2-phenyl, —CO-aryl, arylalkyl, benzyl, aryl, or C3-C7-cycloalkyl;
Q is hydrogen, F, Cl, Br, I, CF3, CN, NO2, COOH, COOR, alkoxy, haloalkyl, optionally substituted linear or branched alkyl, optionally substituted linear or branched heteroalkyl, optionally substituted aryl, optionally substituted phenyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted arylalkyl, C(R)3, N(R)2, NHCOCH3, NHCOCF3, NHCOR, NHCONHR, NHCOOR, OCONHR, CONHR, NHCSCH3, NHCSCF3, NHCSR, NHSO2CH3, NHSO2R, OR, COR, OCOR, OSO2R, SO2R, SR, NCS, SCN, NCO or OCN;
R3 is hydrogen, F, Cl, Br, I, CF3, CN, NO2, NH2, SH, COOH, COOR, alkoxy, haloalkyl, optionally substituted linear or branched alkyl, optionally substituted linear or branched heteroalkyl, optionally substituted aryl, optionally substituted phenyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted arylalkyl, C(R)3, N(R)2, NHCOCH3, NHCOCF3, NHCOR, NHCONHR, NHCOOR, OCONHR, CONHR, NHCSCH3, NHCSCF3, NHCSR, NHSO2CH3, NHSO2R, OR, COR, OCOR, OSO2R, SO2R, SR, NCS, SCN, NCO or OCN;

R4 is hydrogen, F, Cl, Br, I, CF3, CN, NO2, NH2, SH, COOH, COOR, alkoxy, haloalkyl, optionally substituted linear or branched alkyl, optionally substituted linear or branched heteroalkyl, optionally substituted aryl, optionally substituted phenyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted arylalkyl, C(R)3, N(R)2, NHCOCH3, NHCOCF3, NHCOR, NHCONHR, NHCOOR, OCONHR, CONHR, NHCSCH3, NHCSCF3, NHCSR, NHSO2CH3, NHSO2R, OR, COR, OCOR, OSO2R, SO2R, SR, NCS, SCN, NCO or OCN;
n is 1, 2, or 3; and
m is 1, 2, or 3;
or its isomer, pharmaceutically acceptable salt, pharmaceutical product, polymorph, hydrate or any combination thereof.