Patent ID: 11874284
Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
Field: Pharmaceuticals (Chemistry)
Classification: CPC G  A  C | IPC A  G

Claim 0:
1. A method for the treatment of chemotherapy-induced peripheral neuropathy in a subject having a cancer, comprising:
a) obtaining a first sample from the subject before treatment with an anti-cancer agent;
b) obtaining a second sample from the subject after treatment with the anti-cancer agent;
c) determining the expression level of a delta-2-tubulin in the second sample is increased compared to the expression level in the first sample; and
d) administering an siRNA or shRNA targeting cytosolic carboxypeptidase 1 (CCP1), wherein the first sample and the second sample comprise a sample of nervous tissue.