Patent ID: 11932852
Assignee: BENITEC IP HOLDINGS INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC C

Claim 16:
17. A composition comprising:
(a) the nucleic acid according to claim 1;
(b) a ddRNAi construct comprising the nucleic acid of (a);
(c) a DNA construct comprising the ddRNAi construct of (b) and a PABPN1 construct comprising a DNA sequence encoding a functional PABPN1 protein having a mRNA transcript which is not targeted by the shmiR(s) encoded by the ddRNAi construct;
(d) an expression vector comprising (a), (b) or (c); or
(e) a plurality of expression vectors comprising at least one expression vector comprising the ddRNAi construct of (b) and at least one expression vector comprising a PABPN1 construct comprising a DNA sequence encoding a functional PABPN1 protein having a mRNA transcript which is not targeted by the shmiR(s) encoded by the ddRNAi construct;
optionally wherein the composition further comprises one or more pharmaceutically acceptable carriers.