Patent ID: 11939336
Assignee: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION
Field: Chemical engineering (Chemistry)
Classification: CPC C  B | IPC B  C

Claim 3:
4. A method of synthesizing an aryl-triazole bicyclic macrocycle of Formula (II):, wherein R is independently selected from the group consisting of alkenyl, alkyl, alkoxy, alkyl-NH-alkyl, aryl, cycloalkyl, heteroaryl, heterocycle, haloalkyl, hydrogen, iodo, —OR4, —N(R5R6), —CO2R7, —C(O)—N(R8R9), wherein R4, R5, R6, R7, R8, and R9 are each independently selected from the group consisting of alkenyl, alkyl, aryl, arylalkyl, cycloalkyl, heteroaryl, heterocycle, haloalkyl, and hydrogen,
the method comprises:
forming a reaction mixture comprising:, wherein, is selected from the group consisting of, or a combination thereof,

wherein R1, R2, and R3 are independently selected from the group consisting of alkenyl, alkyl, alkoxy, alkyl-NH-alkyl, aryl, cycloalkyl, heteroaryl, heterocycle, haloalkyl, hydrogen, iodo, —OR4, —N(R5R6), —CO2R7, —C(O)—N(R8R9), wherein R4, R5, R6, R7, R8, and R9 are each independently selected from the group consisting of alkenyl, alkyl, aryl, arylalkyl, cycloalkyl, heteroaryl, heterocycle, haloalkyl, and hydrogen;
tripropargylamine; and
a solvent;
incubating the reaction mixture at a reaction temperature above room temperature for a reaction time to form the aryl-triazole bicyclic macrocycle of Formula (II); and
optionally purifying the aryl-triazole bicyclic macrocycle of Formula (II) from the reaction mixture to provide the aryl-triazole bicyclic macrocycle of Formula (II).