Patent ID: 11931454
Assignee: ALCON INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 3:
4. The hydrogel ocular insert of claim 3, wherein said at least one arylborono-containing vinylic monomer is selected from the group consisting of 3-vinylphenylboronic acid, 4-vinylphenylboronic acid, 3-(meth)acrylamidophenylboronic acid, 4-(meth)acrylamidophenyl boronic acid, 3-(meth)acrylamido-5-nitrophenylboronic acid, 4-(meth)acrylamido-5-nitrophenylboronic acid, 4-(meth)acrylamido-3-nitrophenyl-boronic acid, 3-[(meth)acrylamido-C2-C5-alkylaminocarbonyl]-5-nitrophenylboronic acid, 3-[(meth)acryloyloxy-C2-C5-alkylamino-carbonyl]-5-nitrophenyl boronic acid, 3-(meth)acrylamido-6-hydroxymethylphenylboronic acid, 3-(meth)acrylamido-6-dimethylaminomethylphenylboronic acid, 4-(meth)acrylamido-6-hydroxymethylphenyl-boronic acid, 4-(meth)acrylamido-6-dimethylaminomethylphenyl-boronic acid, 4-(1,6-Dioxo-2,5-diaza-7-oxamyl)phenylboronic acid, 4-(N-allylsulfamoyl)phenylboronic acid, 4-(3-butenylsulfonyl)phenylboronic acid, a reaction production of an amino-containing phenylboronic acid derivative with (meth)acrylic acid halide, a reaction product of an amino-containing phenylboronic acid derivative with a carboxy-containing vinylic monomer in the presence of a carbodiimide and N-hydroxysuccinimide, a reaction production of a carboxy-containing phenylboronic acid derivative with an amino-containing vinylic monomer in the presence of a carbodiimide and N-hydroxysuccinimide, and combinations thereof, wherein the carboxy-containing phenylboronic acid derivative is selected from the group consisting of 3-carboxyphenylboronic acid, 4-carboxyphenylboronic acid, 3-boronophenylacetic acid, 4-boronophenylacetic acid, 2-(4-boronophenyl)-2-methylpropanoic acid, 3-(4-boronophenyl)propanoic acid, 3-(3-boronophenyl)propanoic acid, 5-(3-boronophenyl)-pentanoic acid, 5-(4-boronophenyl)pentanoic acid, 4-(2-carboxyethyl)-3-nitrophenyl-boronic acid, 3-carboxy-5-nitrophenylboronic acid, 4-carboxy-3-chlorophenylboronic acid, 3-carboxy-4-fluorophenylbornic acid, 3-(3-carboxypropyonylamino)phenylboronic acid, 3-amino-3-(4-boronophenyl)propanoic acid, and combinations thereof, wherein the amino-containing phenylboronic acid derivative is selected from the group consisting of 3-aminophenylboronic acid, 4-aminophenylboronic acid, 4-amino-3-nitrophenylboronic acid, 3-amino-6-hydroxymethylphenylboronic acid, 3-amino-6-(dimethylaminomethyl)phenylboronic acid, 4-amino-2-hydroxymethylphenylboronic acid, 4-amino-2-(dimethylaminomethyl)phenylboronic acid, 3-amino-4-fluorophenyl-boronic acid, 4-(aminomethyl)-5-nitrophenylboronic acid, 3-(aminomethyl)-phenyl-boronic acid, 3-amino-5-nitrophenylboronic acid, 3-amino-3-(4-boronophenyl)propanoic acid, and combinations thereof, wherein the carboxyl-containing vinylic monomer is selected from the group consisting of 2-acrylamidoglycolic acid, 3-acrylamidopropionic acid, 4-acrylamidobutanoic acid, 5-acrylamidopentanoic acid, 3-acryloyloxypropanoic acid, 4-acryloyloxybutanoic acid, 5-acryloyloxypentanoic acid, and combinations thereof, wherein the amino-containing vinylic monomers is selected from the group consisting of amino-C2-C4 alkyl (meth)acrylate, C1-C3 alkylamino-C2-C4 alkyl (meth)acrylate, amino-C2-C4 alkyl (meth)acrylamide, C1-C3 alkylamino-C2-C4 alkyl (meth)acrylamide, vinylamine, allylamine, and combinations thereof.