Patent ID: 11887828
Assignee: QUEST DIAGNOSTICS INVESTMENTS INCORPORATED
Field: Measurement (Instruments)
Classification: CPC H  G | IPC G  H

Claim 0:
1. A method for detecting or determining the amount of one or more selective serotonin reuptake inhibitors (SSRI) and SSRI metabolites in a sample by tandem mass spectrometry, said method comprising:
a. subjecting the sample to ionization under conditions suitable to produce one or more ions detectable by mass spectrometry;
b. determining the amount of one or more ions by tandem mass spectrometry, wherein the one or more ions comprise a fluoxetine fragment ion with a mass/charge ratio of 148.1±0.2 and a norfluoxetine fragment ion with a mass/charge ratio of 134.2±0.2 or 30.1±0.2; and
c. using the amount of the one or more ions determined in step (b) to determine the amount of SSRI and SSRI metabolites comprising fluoxetine and norfluoxetine in the sample.