Patent ID: 11951150
Assignee: VANDERBILT UNIVERSITY
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 0:
1. A method of treating BCL10-mediated inflammation in a mammalian subject comprising administering to the mammalian subject a composition comprising a pharmaceutically acceptable carrier and a cell-penetrating full-length caspase and receptor interacting protein adaptor with death domain (CP-CRADD), CP-CRADD that lacks its death domain or CP-CRADD that lacks its caspase recruitment domain (CARD) and further comprising, a membrane-translocating motif (MTM) having the sequence AAVLLPVLLAAP (SEQ ID NO: 1), AAVALLPAVLLALLAP (SEQ ID NO:2), or VTVLALGALAGVGVG (SEQ ID NO:3), in an amount sufficient to reduce or block B-cell lymphoma 10 (BCL10) expression or activity thereby reducing or blocking BCL10-mediated inflammation and/or treating a condition associated with BCL10-mediated inflammation in the mammalian subject.