Patent ID: 11891435
Assignee: AMGEN INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A  G  Y | IPC A  C  G

Claim 16:
17. A set of isolated polynucleotides encoding a heavy chain polypeptide and a light chain polypeptide of a monoclonal antibody that specifically binds to human PAC1, comprising:
(i) a first polynucleotide encoding the heavy chain polypeptide, which comprises a heavy chain variable region comprising a CDRH1 comprising the sequence of SEQ ID NO: 88, a CDRH2 comprising the sequence of SEQ ID NO: 108, and a CDRH3 comprising the sequence of SEQ ID NO: 171; and
(ii) a second polynucleotide encoding the light chain polypeptide, which comprises a light chain variable region comprising a CDRL1 comprising the sequence of SEQ ID NO: 7, a CDRL2 comprising the sequence of SEQ ID NO: 26, and a CDRL3 comprising the sequence of SEQ ID NO: 36.