Patent ID: 11923082
Assignee: HANGZHOU CALIBRA DIAGNOSTICS CO., LTD.
Field: Measurement (Instruments)
Classification: CPC G  Y | IPC G

Claim 0:
1. A system for predicting a blood glucose level of a pregnant individual, wherein the system comprises an operation module, and the operation model comprises a support vector regression model, and the system is configured to predict the blood glucose level at 1 hour after taking oral glucose under a fasting state by using concentrations of biomarkers in blood samples of the pregnant individual under the fasting state and the support vector regression model;
wherein the equation of the support vector regression model is:, Y
  =
  
   
    
     ∑
     
      i
      =
      1
     
     m
    
    
     
      W
      i
     
     ·
     
      K
      i
     
    
   
   +
   b
  
 

where, Y is the predicted blood glucose level, i represents the ith biomarker, m represents a number of the biomarkers, Wi represents a weight of the ith biomarker, Ki represents a coefficient of the ith biomarker, and b is a constant;
wherein Ki is calculated by the following formula:

Ki=(γ·μ1·v1+coef)degree 

where, γ, coef and degree are parameters to be adjusted, ui·vi is a linear model of independent variables, i is a linear coefficient of the ith biomarker, and vi is the concentration of the ith biomarker;
wherein m is 19;
wherein the biomarkers are glucose, 1,5-anhydroglucitol, 3-methyl-2-oxobutyrate, 3-hydroxybutyrate, 2-hydroxybutyrate, pantothenic acid, 3-methyl-2-oxovalerate, 4-methyl-2-oxovalerate, palmitoyl glycerol phosphatidylcholine (palmitoyl-GPC), palmitoylcarnitine, oleate, glycine, phenylalanine, serine, tyrosine, isoleucine, leucine, valine, and 2-aminoadipic acid.