Patent ID: 11884943
Assignee: SINGULAR GENOMICS SYSTEMS, INC.
Field: Biotechnology (Chemistry)
Classification: CPC C | IPC C

Claim 1:
2. The polymerase of claim 1, further comprising at least one of the following amino acids:
an alanine at amino acid position 141 or an amino acid position functionally equivalent to amino acid position 141;
an alanine at amino acid position 143 or an amino acid position functionally equivalent to amino acid position 143;
an alanine at amino acid position 144 or an amino acid position functionally equivalent to amino acid position 144;
a glutamic acid at amino acid position 153 or an amino acid position functionally equivalent to amino acid position 153;
an alanine at amino acid position 215 or an amino acid position functionally equivalent to amino acid position 215;
an alanine at amino acid position 315 or an amino acid position functionally equivalent to amino acid position 315;
an alanine at amino acid positions 215 and 315 or amino acid positions functionally equivalent to amino acid positions 215 and 315;
a serine at amino acid position 515 or an amino acid position functionally equivalent to amino acid position 515;
a leucine at amino acid position 522 or an amino acid position functionally equivalent to amino acid position 522;
an isoleucine at amino acid position 591 or an amino acid position functionally equivalent to amino acid position 591;
a tryptophan at amino acid position 477 or an amino acid position functionally equivalent to amino acid position 477;
an alanine at amino acid position 477 or an amino acid position functionally equivalent to amino acid position 477;
an alanine at amino acid position 478 or an amino acid position functionally equivalent to amino acid position 478;
a serine at amino acid position 479 or an amino acid position functionally equivalent to amino acid position 479;
a tryptophan at amino acid position 477 or an amino acid position functionally equivalent to amino acid position 477 and an alanine at amino acid position 478 or an amino acid position functionally equivalent to amino acid position 478;
an alanine at amino acid position 477 or an amino acid position functionally equivalent to amino acid position 477, an alanine at amino acid position 478 or an amino acid position functionally equivalent to amino acid position 478 and a serine at amino acid position 479 or an amino acid position functionally equivalent to amino acid position 479;
an alanine at amino acid position 603 or an amino acid position functionally equivalent to amino acid position 603;
a leucine at amino acid position 640 or an amino acid position functionally equivalent to amino acid position 640;
a glutamic acid at amino acid position 713 or an amino acid position functionally equivalent to amino acid position 713;
an alanine at amino acid position 714 or an amino acid position functionally equivalent to amino acid position 714;
an alanine at amino acid position 719 or an amino acid position functionally equivalent to amino acid position 719;
an alanine at amino acid position 720 or an amino acid position functionally equivalent to amino acid position 720; or
an alanine at amino acid position 736 or an amino acid position functionally equivalent to amino acid position 736.