Patent ID: 11925632
Assignee: GLIAPHARM SA
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 0:
1. A method of treating Glucose transporter 1 deficiency syndrome (GLUT1-DS) in a subject, said method comprising administering in a subject in need thereof a therapeutically effective amount of a compound of Formula (I), wherein R1, R2, R3, R4, R5 and R6 are independently selected from H, halogen, optionally substituted alkoxy, optionally substituted C1-C6 alkyl, optionally substituted amine, optionally substituted carboxylic acid or ester, nitro and nitrile; R7, R8, R9, R10 and R11 independently selected from H, halogen, optionally substituted alkoxy, optionally substituted C1-C6 alkyl, optionally substituted amine, optionally substituted carboxylic acid or ester, nitro and nitrile and a group of Formula (II): —(X)m—CR12R13R14 (II) wherein at least one group of R7, R8, R9, R10 and R11 is a group of Formula (II); X is selected from O, NR15, S, SO2, CH2 and hydrazine (—N—N—), m is an integer elected from 0 and 1 and R12, R13 and R14 are independently selected from H, OH, optionally substituted alkoxy, amide, pyrrolidone, nitrile, optionally substituted C1-C6 alkyl and halogen; Y is selected from —CR16R17— and —NR18—; R15 is selected from H, optionally substituted alkoxy and optionally substituted C1-C6 alkyl; R16 and R17 are independently selected from H, halogen, optionally substituted alkoxy, optionally substituted C1-C6 alkyl and optionally substituted aryl; R18 is independently selected from H or optionally substituted C1-C6 alkyl; pharmaceutically acceptable salts, hydrates, solvates or mixtures thereof.