Patent ID: 11905244
Assignee: THE TEXAS A&M UNIVERSITY SYSTEM
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A method of treatment of a disease, disorder, or condition treatable by inhibiting calcium release-activated calcium (CRAC) channel, comprising administering to a subject in need thereof an amount of a CRAC channel inhibitor effective to inhibit CRAC channel, wherein the CRAC channel inhibitor is a compound of Formula I:, or a pharmaceutically acceptable salt, solvate, or a hydrate thereof, wherein
X is a phenyl substituted with one, two, or three groups selected from optionally substituted C1-C6 alkyl, carboxyl, alkoxycarbonyl, and amido group;
Y is an optionally substituted C1-C8 alkyl, an optionally substituted C6-C10 aryl-C1-C8 alkyl, an optionally substituted C5-C10 heteroaryl-C1-C8 alkyl, an optionally substituted C3-C10 heteroalkyl, an optionally substituted C3-C6 heterocyclyl, an optionally substituted C6-C10 aryl, or an optionally substituted C5-C10 heteroaryl; and
Z is an optionally substituted C6-C10 aryl or an optionally substituted C5-C10 heteroaryl.