Patent ID: 11938164
Assignee: TRUSTEES OF BOSTON UNIVERSITY
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C  G | IPC A

Claim 0:
1. A method of treating an overweight, obese or diabetic subject with cancer, the method comprising administering
(i) a glucose-controlling medication, or obesity medication and/or
(ii) CT scans at a frequency of higher than one CT scan every 6 months to an overweight, obese or diabetic subject with cancer determined to have
(a) an expression level of at least one gene selected from: miR374a-5p, miR-93-5p, miR-28-3p, miR-let-7b-3p, TSP5, SNAI1, TWIST1, SNAI2, vimentin (VIM), ZEB1 and AHNAK in an exosome originating from the adipose tissue or adipocytes of the subject, wherein the expression level of the at least one gene is increased relative to a reference; or
(b) an expression level of at least one gene selected from: miR424-5p, miR-326, miR-27a-3p, miR320b and miR320d in an exosome originating from the adipose tissue or adipocytes of the subject, wherein the expression level of the at least one gene is decreased relative to a reference.