Patent ID: 11964004
Assignee: SHENZHEN BAY LABORATORY
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  Y | IPC A

Claim 0:
1. A short in vivo half-life and in vivo unstable recombinant microplasmin obtained by alanine scanning mutagenesis, wherein the recombinant microplasmin is obtained by expressing in a bacteria host, or refolding and purifying when the recombinant microplasmin is expressed as an insoluble inclusion body, the in vivo half-life of the recombinant microplasmin is about 2.75 to about 28.5 minutes;
wherein the short in vivo half-life and in vivo unstable recombinant microplasmin includes at least one of wild-type, Gly739Ala, Arg582Ala, Met585Ala, Lys607Ala, Phe587Ala, Ser608Ala, Arg610Ala, Glu641Ala, Pro642Ala.