Patent ID: 11929144
Assignee: GENOME RESEARCH LIMITED
Field: Computer technology (Electrical engineering)
Classification: CPC G | IPC G

Claim 5:
6. The method according to claim 1, further comprising:
determining the number of rearrangements Ei in the rearrangement catalogue associated with the ith known mutational signature {right arrow over (S)}i which is proportional to a cosine similarity ({right arrow over (C)}i) between a catalogue of the DNA sample {right arrow over (M)} and {right arrow over (S)}i :, C
    →
   
   i
  
  =
  
   
    
     
      S
      →
     
     i
    
    ·
    
     M
     →
    
   
   
    
     
     
      
       S
       →
      
      i
     
     
    
    ⁢
       
    
     
     
      M
      →
     
     , wherein:, E
   i
  
  =
  
   
    
     
      C
      →
     
     i
    
    
     
      ∑
      
       i
       =
       1
      
      q
     
      
     
      
       C
       →
      
      i
     
    
   
   ⁢
   
    
     ∑
     
      j
      =
      1
     
     36
    
     
    
     
      M
      →
     
     j
    
   
  
 

wherein {right arrow over (S)}i and {right arrow over (M)} are equally-sized vectors with nonnegative components being, respectively, a known rearrangement signature and the rearrangement catalogue, n is the number of categories in said rearrangement catalogue, and q is the number of signatures in said known rearrangement signatures, and wherein Ei, are further constrained by the requirements that, 0
   ≤
   
    E
    i
   
   ≤
   
    
     
     
      
       S
       →
      
      i
     
     
    
    1
   
  
  ,
  
   i
   =
   
    1.
    .
    q
   
  
  ,
  
   
    and
    ⁢
       
    
     
      ∑
      
       i
       =
       1
      
      q
     
      
     
      E
      i
     
    
   
   =
   
    
     
      
      
       
        S
        →
       
       i
      
      
     
     1
    
    .