Patent ID: 11964973
Assignee: BRISTOL-MYERS SQUIBB COMPANY
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC C

Claim 9:
10. A compound or a salt thereof, wherein said compound is:
6-chloro-4-(4-(3-methoxyphenoxy)piperidin-1-yl)-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carbonitrile;
6-chloro-1-methyl-2-oxo-4-(4-(2-(trifluoromethyl)phenoxy)piperidin-1-yl)-1,2-dihydro-1,5-naphthyridine-3-carbonitrile;
6-chloro-4-(4-(3,4-difluorophenoxy)piperidin-1-yl)-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carbonitrile;
6-chloro-1-methyl-2-oxo-4-(4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)-1,2-dihydro-1,5-naphthyridine-3-carbonitrile;
6-chloro-4-(4-(4-methoxyphenoxy)piperidin-1-yl)-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carbonitrile;
4-(4-(4-(tert-butyl)phenoxy)piperidin-1-yl)-6-chloro-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carbonitrile;
6-chloro-4-(4-(4-chlorophenoxy)piperidin-1-yl)-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carbonitrile;
6-chloro-4-(4-(3-fluoro-4-(trifluoromethoxy)phenoxy)piperidin-1-yl)-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carbonitrile;
6-chloro-4-(4-(2-chlorophenoxy)piperidin-1-yl)-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carbonitrile;
6-chloro-1-methyl-2-oxo-4-(4-(4-(trifluoromethoxy)phenoxy)piperidin-1-yl)-1,2-dihydro-1,5-naphthyridine-3-carbonitrile;
6-chloro-4-(4-(4-fluorophenoxy)piperidin-1-yl)-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carbonitrile;
6-chloro-1-methyl-2-oxo-4-(4-(p-tolyloxy)piperidin-1-yl)-1,2-dihydro-1,5-naphthyridine-3-carbonitrile;
6-chloro-1-methyl-2-oxo-4-(4-(m-tolyloxy)piperidin-1-yl)-1,2-dihydro-1,5-naphthyridine-3-carbonitrile;
6-chloro-4-(4-(2-chloro-5-fluorophenoxy)piperidin-1-yl)-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carbonitrile;
6-chloro-1-methyl-2-oxo-4-(4-(3-(trifluoromethyl)phenoxy)piperidin-1-yl)-1,2-dihydro-1,5-naphthyridine-3-carbonitrile;
4-((1-(6-chloro-3-cyano-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridin-4-yl)piperidin-4-yl)oxy)-N,N-dimethylbenzamide;
4-(4-(4-bromo-2-methylphenoxy)piperidin-1-yl)-6-chloro-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carbonitrile;
6-chloro-4-(4-(3-chlorophenoxy)piperidin-1-yl)-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carbonitrile;
6-chloro-4-(4-(3-chloro-5-fluorophenoxy)piperidin-1-yl)-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carbonitrile;
6-chloro-1-methyl-4-(4-(2-methyl-4-(trifluoromethoxy)phenoxy)piperidin-1-yl)-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carbonitrile;
6-chloro-1-methyl-2-oxo-4-(4-(4-(trifluoromethyl)phenoxy)piperidin-1-yl)-1,2-dihydro-1,5-naphthyridine-3-carbonitrile;
4-(4-(4-(tert-butoxy)phenoxy)piperidin-1-yl)-6-chloro-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carbonitrile;
6-chloro-4-(4-(4-cyanophenoxy)piperidin-1-yl)-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carbonitrile;
6-chloro-1-methyl-2-oxo-4-(4-(2-(trifluoromethoxy)phenoxy)piperidin-1-yl)-1,2-dihydro-1,5-naphthyridine-3-carbonitrile;
6-chloro-4-(4-(3-cyanophenoxy)piperidin-1-yl)-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carbonitrile;
6-chloro-4-(4-(2-methoxyphenoxy)piperidin-1-yl)-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carbonitrile;
6-chloro-4-(4-(4-fluoro-2-methoxyphenoxy)piperidin-1-yl)-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carbonitrile;
6-chloro-4-(4-(4-isopropylphenoxy)piperidin-1-yl)-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carbonitrile;
6-chloro-4-(4-(3-chloro-4-cyanophenoxy)piperidin-1-yl)-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carbonitrile;
6-chloro-4-(4-(4-chloro-3-methoxyphenoxy)piperidin-1-yl)-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carbonitrile;
6-chloro-4-(4-(3-chloro-4-methylphenoxy)piperidin-1-yl)-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carbonitrile;
6-chloro-4-(4-(2-chloro-4-(trifluoromethoxy)phenoxy)piperidin-1-yl)-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carbonitrile;
6-chloro-4-(4-(3-chloro-4-(trifluoromethoxy)phenoxy)piperidin-1-yl)-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carbonitrile;
6-chloro-4-(4-(2-cyanophenoxy)piperidin-1-yl)-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carbonitrile;
6-chloro-4-(4-(2-fluorophenoxy)piperidin-1-yl)-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carbonitrile;
6-chloro-4-(4-(3-fluorophenoxy)piperidin-1-yl)-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carbonitrile;
6-chloro-1-methyl-2-oxo-4-(4-phenoxypiperidin-1-yl)-1,2-dihydro-1,5-naphthyridine-3-carbonitrile;
6-bromo-1-methyl-2-oxo-4-(4-(4-(trifluoromethoxy)phenoxy)piperidin-1-yl)-1,2-dihydro-1,5-naphthyridine-3-carbonitrile;
6-methoxy-1-methyl-2-oxo-4-(4-(4-(trifluoromethoxy)phenoxy)piperidin-1-yl)-1,2-dihydro-1,5-naphthyridine-3-carbonitrile;
1-methyl-2,6-dioxo-4-(4-(4-(trifluoromethoxy)phenoxy)piperidin-1-yl)-1,2,5,6-tetrahydro-1,5-naphthyridine-3-carbonitrile;
5-methyl-6-oxo-8-(4-(4-(trifluoromethoxy)phenoxy)piperidin-1-yl)-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile;
5-methyl-7-nitro-6-oxo-8-(4-(4-(trifluoromethoxy)phenoxy)piperidin-1-yl)-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
5-methyl-6-oxo-8-(4-(4-(trifluoromethoxy)phenoxy)piperidin-1-yl)-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
4-(4-(4-(tert-butyl)phenoxy)piperidin-1-yl)-1-methyl-2-oxo-1,2-dihydroquinoline-6-carbonitrile;
5-methyl-6-oxo-8-(4-(4-(tert-pentyl)phenoxy)piperidin-1-yl)-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-(4-(4-benzylphenoxy)piperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-(4-(4-butylphenoxy)piperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
5-methyl-6-oxo-8-(4-(4-propylphenoxy)piperidin-1-yl)-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-(4-(4-cyclopentylphenoxy)piperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-(4-(4-cyclopropylphenoxy)piperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-(4-(4-isopropyl-3-methylphenoxy)piperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
5-methyl-6-oxo-8-(4-((5,6,7,8-tetrahydronaphthalen-2-yl)oxy)piperidin-1-yl)-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
5-methyl-6-oxo-8-(4-(4-pentylphenoxy)piperidin-1-yl)-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-(4-(4-cyclohexylphenoxy)piperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-(4-(4-(2-cyclohexylpropan-2-yl)phenoxy)piperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-(4-(4-(tert-butoxy)phenoxy)piperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-(4-((5-isopropoxypyridin-2-yl)oxy)piperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-(4-((5-chloropyridin-2-yl)oxy)piperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-(4-((6-(tert-butyl)pyridazin-3-yl)oxy)piperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
5-methyl-6-oxo-8-(4-(quinoxalin-2-yloxy)piperidin-1-yl)-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-(4-((2,6-dimethylpyrimidin-4-yl)oxy)piperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
5-methyl-6-oxo-8-(4-(quinazolin-4-yloxy)piperidin-1-yl)-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
5-methyl-8-(4-((2-methylpyrimidin-4-yl)oxy)piperidin-1-yl)-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-(4-((7-chloro-4-methoxyquinolin-2-yl)oxy)piperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-(4-((1,7-naphthyridin-8-yl)oxy)piperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
5-methyl-6-oxo-8-(4-(phthalazin-1-yloxy)piperidin-1-yl)-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
5-methyl-6-oxo-8-(4-((2-(trifluoromethyl)pyrimidin-4-yl)oxy)piperidin-1-yl)-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
5-methyl-6-oxo-8-(4-((5-(trifluoromethyl)pyridin-2-yl)oxy)piperidin-1-yl)-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-(4-(2-isopropyl-6-methylpyrimidin-4-yl)oxy)piperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
(+/−) 6-cyano-1-methyl-4-((3R,4R)-3-methyl-4-(4-(trifluoromethoxy)phenoxy)piperidin-1-yl)-1,5-naphthyridin-2(1H)-one;
6-cyano-1-methyl-4-((3R,4R)-3-methyl-4-(4-(trifluoromethoxy)phenoxy)piperidin-1-yl)-1,5-naphthyridin-2(1H)-one;
6-cyano-1-methyl-4-((3R,4R)-3-methyl-4-(4-(trifluoromethoxy)phenoxy)piperidin-1-yl)-1,5-naphthyridin-2(1H)-one;
5-methyl-8-((3R,4R)-3-methyl-4-(4-(tert-pentyl)phenoxy)piperidin-1-yl)-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((3R,4R)-4-(4-(tert-butoxy)phenoxy)-3-methylpiperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((3R,4R)-4-(4-(tert-butyl)phenoxy)-3-methylpiperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((3R,4R)-4-(3-cyclopropylphenoxy)-3-methylpiperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((3R,4R)-4-(4-isopropylphenoxy)-3-methylpiperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
5-methyl-8-((3R,4R)-3-methyl-4-(4-(trifluoromethyl)phenoxy)piperidin-1-yl)-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((3R,4R)-4-(4-cyclopentylphenoxy)-3-methylpiperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((3R,4R)-4-(3,4-difluorophenoxy)-3-methylpiperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((3R,4R)-4-(4-cyclohexylphenoxy)-3-methylpiperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
5-methyl-8-((3R,4R)-3-methyl-4-(m-tolyloxy)piperidin-1-yl)-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((3R,4R)-4-(4-ethylphenoxy)-3-methylpiperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((3R,4R)-4-(4-cyclopropylphenoxy)-3-methylpiperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((3R,4R)-4-(2-fluoro-4-(trifluoromethyl)phenoxy)-3-methylpiperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((3R,4R)-4-(2,4-difluorophenoxy)-3-methylpiperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((3R,4R)-4-(4-fluoro-2-(trifluoromethyl)phenoxy)-3-methylpiperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
5-methyl-8-((3R,4R)-3-methyl-4-(p-tolyloxy)piperidin-1-yl)-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((3R,4R)-4-(3-isopropylphenoxy)-3-methylpiperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((3R,4R)-4-(3-(tert-butyl)phenoxy)-3-methylpiperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((3R,4R)-4-(2-fluoro-6-(trifluoromethyl)phenoxy)-3-methylpiperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((3R,4R)-4-(2,6-difluorophenoxy)-3-methylpiperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((3R,4R)-4-(4-fluorophenoxy)-3-methylpiperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
5-methyl-8-((3R,4R)-3-methyl-4-(2,4,6-trifluorophenoxy)piperidin-1-yl)-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((3R,4R)-4-((3,4-dihydro-2H-benzo[b][1,4]dioxepin-6-yl)oxy)-3-methylpiperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
5-methyl-8-((3R,4R)-3-methyl-4-(m-tolyloxy)piperidin-1-yl)-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile;
8-((3R,4R)-3-ethyl-4-(3-isopropylphenoxy)piperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((3R,4R)-3-ethyl-4-(3-(trifluoromethyl)phenoxy)piperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((3R,4R)-3-ethyl-4-(4-isopropylphenoxy)piperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((3R,4R)-3-ethyl-4-(4-(trifluoromethyl)phenoxy)piperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((3R,4R)-3-ethyl-4-(4-(tert-pentyl)phenoxy)piperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((3R,4R)-4-(4-(tert-butyl)phenoxy)-3-ethylpiperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((3R,4R)-4-(3-cyclopropylphenoxy)-3-ethylpiperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((3R,4R)-4-(4-(tert-butoxy)phenoxy)-3-ethylpiperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((3R,4R)-3-ethyl-4-(4-isopropoxyphenoxy)piperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((3R,4R)-3-ethyl-4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((3R,4S)-3-ethyl-4-(3-isopropylphenoxy)piperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((3R,4S)-4-(3-(tert-butyl)phenoxy)-3-ethylpiperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
5-methyl-8-((3R,4S)-3-methyl-4-(4-(tert-pentyl)phenoxy)piperidin-1-yl)-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((3R,4S)-4-(4-(tert-butoxy)phenoxy)-3-methylpiperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((3R,4S)-4-(4-(tert-butyl)phenoxy)-3-methylpiperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((3R,4S)-4-(4-isopropylphenoxy)-3-methylpiperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((3R,4S)-4-(3-cyclopropylphenoxy)-3-methylpiperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((3R,4S)-4-(4-isopropylphenoxy)-3-methylpiperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
(+/−) 5-methyl-8-((3R,4S)-3-methyl-4-(4-(trifluoromethyl)phenoxy)piperidin-1-yl)-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carboxamide;
(+/−) 5-methyl-8-((3R,4S)-3-methyl-4-(4-(trifluoromethyl)phenoxy)piperidin-1-yl)-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
5-methyl-8-((3R,4S)-3-methyl-4-(4-(trifluoromethyl)phenoxy)piperidin-1-yl)-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
5-methyl-8-((3R,4S)-3-methyl-4-(4-(trifluoromethyl)phenoxy)piperidin-1-yl)-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
5-methyl-8-((3R,4S)-3-methyl-4-(4-(trifluoromethyl)phenoxy)piperidin-1-yl)-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile;
8-((3R,4R)-3-ethyl-4-((5-isopropoxypyridin-2-yl)oxy)piperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((3R,4R)-3-ethyl-4-(4-fluoro-3-propylphenoxy)piperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((3R,4R)-4-(3-(tert-butyl)phenoxy)-3-ethylpiperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((3R,4R)-4-((5-isopropoxypyridin-2-yl)oxy)-3-methylpiperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((3R,4S)-3-ethyl-4-((5-isopropoxypyridin-2-yl)oxy)piperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((3R,4S)-4-((5-isopropylpyridin-2-yl)oxy)-3-methylpiperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((3R,4S)-4-((5-(difluoromethyl)pyridin-2-yl)oxy)-3-methylpiperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((3R,4S)-4-(4-isopropylpyridin-2-yl)oxy)-3-methylpiperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((3R,4S)-4-(6-isopropylpyridin-2-yl)oxy)-3-methylpiperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
5-methyl-8-((3R,4S)-3-methyl-4-(pyrimidin-2-yloxy)piperidin-1-yl)-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((3R,4S)-4-((4-methoxypyrimidin-2-yl)oxy)-3-methylpiperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
5-methyl-8-((3R,4S)-3-methyl-4-((5-propylpyrimidin-2-yl)oxy)piperidin-1-yl)-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
5-methyl-8-((3R,4S)-3-methyl-4-((2-methylpyrimidin-4-yl)oxy)piperidin-1-yl)-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((3R,4S)-4-((5-ethylpyrimidin-2-yl)oxy)-3-methylpiperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
5-methyl-8-((3R,4S)-3-methyl-4-((5-(trifluoromethyl)pyrimidin-2-yl)oxy)piperidin-1-yl)-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((3R,4S)-4-((5-cyclopropylpyrimidin-2-yl)oxy)-3-methylpiperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((3R,4S)-4-((5-cyclopropylpyridin-2-yl)oxy)-3-methylpiperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
5-methyl-8-((3R,4S)-3-methyl-4-((5-(trifluoromethyl)pyridin-2-yl)oxy)piperidin-1-yl)-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
(+/−) 8-((3R,4S)-4-((5-isopropoxypyridin-2-yl)oxy)-3-methylpiperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
(+/−) 5-methyl-8-((3R,4R)-3-methyl-4-(4-(tert-pentyl)phenoxy)piperidin-1-yl)-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile;
5-methyl-8-((3R,4R)-3-methyl-4-(4-(tert-pentyl)phenoxy)piperidin-1-yl)-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile;
5-methyl-8-((3R,4R)-3-methyl-4-(4-(tert-pentyl)phenoxy)piperidin-1-yl)-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile;
(+/−) 8-(4-((5-isopropoxypyridin-2-yl)oxy)-3,3-dimethylpiperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-(4-((5-isopropoxypyridin-2-yl)oxy)-3,3-dimethylpiperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-(4-((5-isopropoxypyridin-2-yl)oxy)-3,3-dimethylpiperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
(+/−) 5-methyl-8-((3R,4S)-3-methyl-4-((4-(trifluoromethoxy)benzyl)oxy)piperidin-1-yl)-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
(+/−) 5-methyl-8-((3R,4S)-3-methyl-4-((4-(trifluoromethoxy)benzyl)oxy)piperidin-1-yl)-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carboxamide;
7-fluoro-5-methyl-6-oxo-8-(4-(4-(trifluoromethoxy)phenoxy)piperidin-1-yl)-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
7-chloro-5-methyl-6-oxo-8-(4-(4-(trifluoromethoxy)phenoxy)piperidin-1-yl)-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
7-bromo-5-methyl-6-oxo-8-(4-(4-(trifluoromethoxy)phenoxy)piperidin-1-yl)-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
7-(6-methoxypyridin-3-yl)-5-methyl-6-oxo-8-(4-(4-(trifluoromethoxy)phenoxy)piperidin-1-yl)-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
7-(2-methoxypyridin-4-yl)-5-methyl-6-oxo-8-(4-(4-(trifluoromethoxy)phenoxy)piperidin-1-yl)-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
(+/−) 6-bromo-1-methyl-4-((3R,4R)-3-methyl-4-(4-(tert-pentyl)phenoxy)piperidin-1-yl)-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carbonitrile;
8-((2S,5S)-4-((5-isopropoxypyridin-2-yl)oxy)-2,5-dimethylpiperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((2R,5R)-4-((5-isopropoxypyridin-2-yl)oxy)-2,5-dimethylpiperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
4-((2R,5S)-4-((5-isopropoxypyridin-2-yl)oxy)-2,5-dimethylpiperidin-1-yl)-1-methyl-2-oxo-1,2-dihydropyrido[3,2-d]pyrimidine-6-carbonitrile;
4-((2S,5R)-4-((5-isopropoxypyridin-2-yl)oxy)-2,5-dimethylpiperidin-1-yl)-1-methyl-2-oxo-1,2-dihydropyrido[3,2-d]pyrimidine-6-carbonitrile;
4-((2R,5S)-2,5-dimethyl-4-(3-(trifluoromethyl)phenoxy)piperidin-1-yl)-1-methyl-2-oxo-1,2-dihydropyrido[3,2-d]pyrimidine-6-carbonitrile;
4-((2S,5R)-2,5-dimethyl-4-(3-(trifluoromethyl)phenoxy)piperidin-1-yl)-1-methyl-2-oxo-1,2-dihydropyrido[3,2-d]pyrimidine-6-carbonitrile;
4-((2R,5R)-2,5-dimethyl-4-(3-(trifluoromethyl)phenoxy)piperidin-1-yl)-1-methyl-2-oxo-1,2-dihydropyrido[3,2-d]pyrimidine-6-carbonitrile;
8-((2S,5S)-2,5-dimethyl-4-(3-(trifluoromethyl)phenoxy)piperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
(±)-trans-8-(3-hydroxy-4-(3-(trifluoromethyl)phenoxy)piperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
(±)-trans-8-(3-methoxy-4-(3-(trifluoromethyl)phenoxy)piperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((3R,4R)-3-ethoxy-4-(3-(trifluoromethyl)phenoxy)piperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
(±)-cis-8-(3-fluoro-4-(3-(trifluoromethyl)phenoxy)piperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
(±)-trans-8-(3-hydroxy-4-((5-isopropoxypyridin-2-yl)oxy)piperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
(±)-trans-8-(4-((5-isopropoxypyridin-2-yl)oxy)-3-methoxypiperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
(±)-trans-6-chloro-4-(3-hydroxy-4-(3-(trifluoromethyl)phenoxy)piperidin-1-yl)-1-methylpyrido[3,2-d]pyrimidin-2(1H)-one;
(±)-trans-4-(3-hydroxy-4-(3-(trifluoromethyl)phenoxy)piperidin-1-yl)-1-methyl-2-oxo-1,2-dihydropyrido[3,2-d]pyrimidine-6-carbonitrile;
6-chloro-4-((3R,4R)-3-methoxy-4-(3-(trifluoromethyl)phenoxy)piperidin-1-yl)-1-methylpyrido[3,2-d]pyrimidin-2(1H)-one;
(±)-trans-4-(3-hydroxy-4-(3-(trifluoromethyl)phenoxy)piperidin-1-yl)-1-methyl-2-oxo-1,2-dihydropyrido[3,2-d]pyrimidine-6-carbonitrile;
4-((3R,4R)-3-ethoxy-4-(3-(trifluoromethyl)phenoxy)piperidin-1-yl)-1-methyl-2-oxo-1,2-dihydropyrido[3,2-d]pyrimidine-6-carbonitrile;
8-((2S,5R)-4-((5-methoxypyridin-2-yl)amino)-2,5-dimethylpiperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
N-((2S,5R)-1-(6-cyano-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridin-4-yl)-2,5-dimethylpiperidin-4-yl)-4-fluoro-N-methylbenzamide;
N-(1-(6-cyano-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridin-4-yl)-3-methylpiperidin-4-yl)-4-fluoro-N-methylbenzamide;
N-(1-(3,6-dicyano-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridin-4-yl)-3-methylpiperidin-4-yl)-N-methyl-4-(trifluoromethyl)benzamide;
8-((2S,4S,5S)-5-ethyl-4-((5-isopropoxypyridin-2-yl)oxy)-2-methylpiperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((2R,4S,5S)-5-ethyl-4-((5-isopropoxypyridin-2-yl)oxy)-2-methylpiperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((2S,4R,5R)-5-ethyl-4-((5-isopropoxypyridin-2-yl)oxy)-2-methylpiperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((2R,4R,5R)-5-ethyl-4-((5-isopropoxypyridin-2-yl)oxy)-2-methylpiperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((2R,4S,5R)-5-ethyl-4-((5-isopropoxypyridin-2-yl)oxy)-2-methylpiperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((2S,4S,5R)-5-ethyl-4-((5-isopropoxypyridin-2-yl)oxy)-2-methylpiperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
6-chloro-4-((2S,4R,5R)-5-ethyl-4-((5-isopropoxypyridin-2-yl)oxy)-2-methylpiperidin-1-yl)-1-methylpyrido[3,2-d]pyrimidin-2(1H)-one;
4-((2S,4R,5R)-5-ethyl-4-((5-isopropoxypyridin-2-yl)oxy)-2-methylpiperidin-1-yl)-1-methyl-2-oxo-1,2-dihydropyrido[3,2-d]pyrimidine-6-carbonitrile;
6-chloro-4-((2R,4R,5R)-5-ethyl-4-((5-isopropoxypyridin-2-yl)oxy)-2-methylpiperidin-1-yl)-1-methylpyrido[3,2-d]pyrimidin-2(1H)-one;
4-((2R,4R,5R)-5-ethyl-4-((5-isopropoxypyridin-2-yl)oxy)-2-methylpiperidin-1-yl)-1-methyl-2-oxo-1,2-dihydropyrido[3,2-d]pyrimidine-6-carbonitrile;
6-chloro-4-((2R,4S,5R)-5-ethyl-4-((5-isopropoxypyridin-2-yl)oxy)-2-methylpiperidin-1-yl)-1-methylpyrido[3,2-d]pyrimidin-2(1H)-one;
4-((2R,4S,5R)-5-ethyl-4-((5-isopropoxypyridin-2-yl)oxy)-2-methylpiperidin-1-yl)-1-methyl-2-oxo-1,2-dihydropyrido[3,2-d]pyrimidine-6-carbonitrile;
6-chloro-4-((2S,4S,5R)-5-ethyl-4-((5-isopropoxypyridin-2-yl)oxy)-2-methylpiperidin-1-yl)-1-methylpyrido[3,2-d]pyrimidin-2(1H)-one;
4-((2S,4S,5R)-5-ethyl-4-((5-isopropoxypyridin-2-yl)oxy)-2-methylpiperidin-1-yl)-1-methyl-2-oxo-1,2-dihydropyrido[3,2-d]pyrimidine-6-carbonitrile;
8-((2S,4S,5R)-5-ethyl-2-methyl-4-(3-(trifluoromethyl)phenoxy)piperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((2R,4S,5R)-5-ethyl-2-methyl-4-(3-(trifluoromethyl)phenoxy)piperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((2R,4R,5R)-5-ethyl-2-methyl-4-(3-(trifluoromethyl)phenoxy)piperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((2R,4S,5R)-2,5-dimethyl-4-(3-(trifluoromethyl)phenoxy)piperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((2S,4R,5S)-2,5-dimethyl-4-(p-tolyloxy)piperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((2S,4R,5S)-4-(3-chlorophenoxy)-2,5-dimethylpiperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((2S,4R,5S)-4-(3-cyanophenoxy)-2,5-dimethylpiperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((2S,4R,5S)-4-(4-fluorophenoxy)-2,5-dimethylpiperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((2S,5S)-2,5-dimethyl-4-((4-(trifluoromethyl)phenyl)amino)piperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (316A);
8-(2,5)-dimethyl-4-(methyl(4-(trifluoromethyl)phenyl)amino)piperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((2S,5S)-2,5-dimethyl-4-(methyl(3-(trifluoromethyl)phenyl)amino)piperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-(4-((4-fluorobenzyl)(methyl)amino)-3-methylpiperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile;
8-(4-((4-fluorobenzyl)(methyl)amino)-3-methylpiperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-(4-((4,4-difluorocyclohexyl)(methyl)amino)-3-methylpiperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile;
8-((2S,5R)-4-((4-fluorobenzyl)(methyl)amino)-2,5-dimethylpiperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((2S,5S)-4-((4-fluorobenzyl)(methyl)amino)-2,5-dimethylpiperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((2S,5S)-4-((5-Isopropoxypyridin-2-yl)oxy)-2,4,5-trimethylpiperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
5-methyl-6-oxo-8-((2S,5S)-2,4,5-trimethyl-4-(3-(trifluoromethyl)phenoxy)piperidin-1-yl)-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
1-methyl-2-oxo-4-((2S,5S)-2,4,5-trimethyl-4-(3-(trifluoromethyl)phenoxy)piperidin-1-yl)-1,2-dihydropyrido[3,2-d]pyrimidine-6-carbonitrile;
trans-8-(3-ethoxy-4-phenoxypiperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((3S,4S)-3-ethoxy-4-(4-(trifluoromethyl)phenoxy)piperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((3S,4S)-3-ethoxy-4-(2-(trifluoromethyl)phenoxy)piperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((3S,4S)-3-ethoxy-4-(4-isopropoxyphenoxy)piperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((3S,4S)-3-ethoxy-4-(4-(trifluoromethoxy)phenoxy)piperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((3S,4S)-3-ethoxy-4-(3-(trifluoromethoxy)phenoxy)piperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((3S,4S)-3-ethoxy-4-(4-(methylsulfonyl)phenoxy)piperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((3S,4S)-3-ethoxy-4-((2-methylbenzo[d]oxazol-5-yl)oxy)piperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((3S,4S)-4-(4-chloro-3-fluorophenoxy)-3-ethoxypiperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((3S,4S)-3-ethoxy-4-((2-(trifluoromethyl)pyridin-4-yl)oxy)piperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
trans-8-(3-ethoxy-4-((6-(trifluoromethyl)pyridin-2-yl)oxy)piperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((3S,4S)-3-ethoxy-4-((4-(trifluoromethyl)pyridin-2-yl)oxy)piperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
trans-8-(3-ethoxy-4-((5-(trifluoromethyl)pyridin-2-yl)oxy)piperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
cis-8-(3-ethoxy-4-(3-(trifluoromethyl)phenoxy)piperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
cis-8-(3-ethoxy-4-((5-isopropoxypyridin-2-yl)oxy)piperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
trans-8-4-(benzo[d]thiazol-2-yloxy)-3-ethoxypiperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((3S,4S)-3-ethoxy-4-((6-isopropoxypyridazin-3-yl)oxy)piperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((3S,4S)-3-ethoxy-4-((5-isopropoxypyrazin-2-yl)oxy)piperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((3S,4S)-3-ethoxy-4-((5-isopropoxypyrimidin-2-yl)oxy)piperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((3S,4S)-3-ethoxy-4-((3-(trifluoromethyl)benzyl)oxy)piperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((3S,4S)-3-ethoxy-4-((5-isopropoxypyridin-2-yl)methoxy)piperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((3R,4R)-3-(2-(dimethylamino)ethoxy)-4-(3-(trifluoromethyl)phenoxy)piperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((3R,4R)-3-(cyclopropylmethoxy)-4-(3-(trifluoromethyl)phenoxy)piperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
8-((3R,4R)-3-(2-methoxyethoxy)-4-(3-(trifluoromethyl)phenoxy)piperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
5-methyl-8-((3R,4R)-3-(2-morpholinoethoxy)-4-(3-(trifluoromethyl)phenoxy)piperidin-1-yl)-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
5-methyl-6-oxo-8-((3R,4R)-3-(2,2,2-trifluoroethoxy)-4-(3-(trifluoromethyl)phenoxy) piperidin-1-yl)-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
trans-8-(3-isopropoxy-4-(3-(trifluoromethyl)phenoxy)piperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
trans-8-(4-((5-isopropoxypyridin-2-yl)oxy)-3-ethoxypiperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile;
(±)-trans-6-chloro-4-(3-ethoxy-4-((5-isopropoxypyridin-2-yl)oxy)piperidin-1-yl)-1-methylpyrido[3,2-d]pyrimidin-2(1H)-one;
trans-4-(3-ethoxy-4-((5-isopropoxypyridin-2-yl)oxy)piperidin-1-yl)-1-methyl-2-oxo-1,2-dihydropyrido[3,2-d]pyrimidine-6-carbonitrile;
trans-4-(3-ethoxy-4-phenoxypiperidin-1-yl)-1-methyl-2-oxo-1,2-dihydropyrido[3,2-d] pyrimidine-6-carbonitrile; or
4-((3S,4S)-3-ethoxy-4-(4-(trifluoromethyl)phenoxy)piperidin-1-yl)-1-methyl-2-oxo-1,2-dihydropyrido[3,2-d]pyrimidine-6-carbonitrile.