Patent ID: 11885816
Assignee: UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER AT FORTH WORTH
Field: Measurement (Instruments)
Classification: CPC G  A  C | IPC C  G

Claim 0:
1. A method for treating a human subject with Alzheimer's Disease having a high proinflammatory endophenotype, the method comprising:
obtaining a blood sample from the human subject with Alzheimer's disease;
measuring the protein expression levels of tumor necrosis factor-alpha (TNFα), IL-5, IL-6, and C-reactive protein (CRP) biomarkers in the blood sample;
applying an algorithm to the measured protein expression levels, the algorithm generating an endophenotype score based on a comparison of the measured protein expression levels to reference levels;
identifying the human subject with Alzheimer's Disease as having a high proinflammatory endophenotype profile based on the endophenotype score; and
administering an anti-inflammatory drug treatment to the identified human subject;
wherein the algorithm is selected from a machine learning algorithm, a clustering algorithm, and a combination thereof.