Patent ID: 11866449
Assignee: NSC THERAPEUTICS GMBH
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 9:
10. An oral capsule comprising crystalline polymorph Form III of Compound A having the formula, and
(i) having an X-ray powder diffraction pattern containing at least one of the following 2-theta values (±0.2) as measured using CuKα radiation: 12.3, 17.3, 17.5, 19.9, 21.6, 24.6, 26.3, and 35.4, and substantially free of peaks having 2-theta values in the range of 10.8-11.9;
(ii) wherein the 13C solid-state NMR of the crystalline form contains at least one resonance having one of the following chemical shift values as expressed in ppm relative to TMS: 67.56, 54.60, 47.07, 41.49, 30.70 and 13.77;
(iii) wherein the 13C solid-state NMR of the crystalline form contains a difference in chemical shift between the resonance having the largest chemical shift and another resonance of 107.3, 120.3, 127.9, 133.4, 144.2 or 161.1;
(iv) wherein the ZnSe ATR-FT-IR absorption spectrum of the crystalline form contains at least one absorption peak having a value selected from 1039, 1353, 1369, 1369, 1388, 2918, 2974 and 3088 cm−1; or
(v) wherein the crystalline form exhibits a very broad endothermic peak at 58-94° C. and an endothermic peak with an onset at 133.7° C. and a peak at 134.9° C. as measured by differential scanning calorimetry (DSC).