Patent ID: 11963954
Assignee: ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 5:
6. A compound having a structure represented by a formula:, or a pharmaceutically acceptable salt thereof, wherein
R1a, R1b, and R1c are each independently hydrogen, halogen, —SF5, —NO2, —CH3, —CH2F, —CHF2, —CF3, —OCF3, —NHCH3, —N(CH3)2, —(CH2)-phenyl, —(CH2)-pyridinyl, —(CH2)-pyrimidinyl, —O-phenyl, —O-pyridinyl, or —O-pyrimidinyl, provided that at least one of R1a, R1b, and R1c is not hydrogen; or wherein R1a and R1b are optionally covalently bonded and, together with the intermediate atoms, comprise an optionally substituted 3- to 7-membered fused aryl, heteroaryl, cycloalkyl, cycloalkenyl, heterocycloalkyl, or heterocycloalkenyl; and wherein R1c is hydrogen, halogen, —OH, —SCF3, —SF5, —NO2, —CH3, —CH2F, —CHF2, —CF3, —OCF3, —NHCH3, or —N(CH3)2;
R2 is —(C1-C6 alkyl)-CF3, —(C1-C6 alkyl)-C≡CH, —(C1-C3 alkyl)-cyclopropyl, —(C1-C3 alkyl)-cyclobutyl, —(C1-C3 alkyl)-cyclopentyl, —(C1-C3 alkyl)-cyclohexyl, or —SO2—(C1-C6 alkyl); and wherein R2 is substituted with 0, 1, 2, or 3 groups independently selected from halogen, —OH, —SCF3, —SF5, —NO2, —CH3, —CH2F, —CHF2, —CF3, —OCF3, —NHCH3, and —N(CH3)2; and
R3 is C1-C8 alkyl, C1-C8 alkoxyalkyl, —(C1-C3 alkyl)-(C3-C8 cycloalkyl), or —(C1-C3 alkyl)-Ar1;
wherein Ar1 is phenyl substituted with 0, 1, 2, or 3 groups independently selected from halogen, —SF5, —NO2, —CH3, —CH2F, —CHF2, —CF3, —OCF3, —NHCH3, —N(CH3)2, —C(O)CH═CH2, —(CH2)C(O)CH═CH2, —NHC(O)CH═CH2, and —(CH2)NHC(O)CH═CH2, or Ar1 is pyridinyl having a structure represented by:, wherein R20a, R20b, R20c, and R20d are each independently selected from hydrogen, halogen, —SF5, —NO2, —CH3, —CH2F, —CHF2, —CF3, —OCF3, —NHCH3, —N(CH3)2, —C(O)CH═CH2, —(CH2)C(O)CH═CH2, —NHC(O)CH═CH2, and —(CH2)NHC(O)CH═CH2, provided that at least one of R20a, R20b, R20c, and R20d is hydrogen.