Patent ID: 11945842
Assignee: INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY (ICGEB)
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A  Y | IPC A  C

Claim 7:
8. A recombinant expression system comprising an expression vector, wherein the expression vector comprises a nucleic acid encoding an EDIII-T polypeptide comprising an EDIII domain of each of Dengue virus serotypes DENY-1, DENV-2, DENV-3, and DENV-4, wherein the C-terminal end of EDIII-T is fused to the N-terminal end of an HBsAg polypeptide, wherein upon expression of the expression vector in a host cell, functional dengue virus like particles are formed comprising each of dengue virus serotypes DENY-1, DENV-2, DENV-3, and DENV-4.