Patent ID: 11878063
Assignee: THE GENERAL HOSPITAL CORPORATION
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 0:
1. An engineered ligand that binds to a human parathyroid hormone receptor 1 (PTHR1), the engineered ligand comprising a sub-optimal ligand conjugated to an antibody that binds to PTHR1;
wherein the sub-optimal ligand comprises an N-terminal fragment of parathyroid hormone (PTH) comprising amino acids 1-9 of PTH (SEQ ID NO: 3) and not comprising amino acids 15-34 of PTH (SEQ ID NO: 3);
wherein the antibody is a nanobody;
wherein the sub-optimal ligand comprises a C-terminus and an N-terminus;
wherein the antibody comprises a C-terminus and an N-terminus; and
wherein the C-terminus of the sub-optimal ligand is conjugated to the C-terminus or the N-terminus of the antibody and wherein the antibody binds to an epitope consisting of the amino acid sequence of any one of SEQ ID NO: 53-55.