Patent ID: 11919991
Assignee: CARNEGIE MELLON UNIVERSITY
Field: Macromolecular chemistry, polymers (Chemistry)
Classification: CPC C | IPC C

Claim 11:
12. An oxygen-driven atom transfer radical polymerization (ATRP) method, wherein the method comprises combining free radically copolymerizable monomers with:
(a) a deoxygenated aqueous polymerization medium comprising (i) copper at a concentration less than 1500 ppm, wherein the copper is capable of participating in a redox reaction, and (ii) a halogen-containing initiator comprising one or more redox transferable atoms or groups;
(b) an oxygen scavenger comprising glucose and glucose oxidase (Gox); and
(c) a reactive oxygen species (ROS) scavenger comprising one or more of horseradish peroxidase, an α-keto-acid, a catalase, or a catalase-like enzyme selected from the group consisting of ascorbate peroxidase, cytochrome C peroxidase, haloperoxidase, hemoprotein, glutathione peroxidase, laccase, monoamine oxidase, cytochrome P450 oxidase, NADPH oxidase, xanthine oxidase, L-gulonolactone oxidase, and superoxide dismutase,
wherein the concentrations of the oxygen scavenger and the ROS scavenger are sufficient to provide a continuous source of radicals for controlled polymerization from the halogen-containing initiator.