Patent ID: 11921020
Assignee: UNIVERSITY OF IOWA RESEARCH FOUNDATION
Field: Measurement (Instruments)
Classification: CPC G  B  C | IPC B  C  G

Claim 0:
1. A method for purifying viable cancerous cells in an in vitro fluid preparation comprising viable cancerous cells, viable normal cells, and extracellular calcium, the method comprising:
applying an initial pulse of fluid shear stress to the preparation, wherein the initial pulse of fluid shear stress induces a fluid shear stress resistance in the viable cancerous cells such that the magnitude of shear stress required to kill the viable cancerous cells is greater than the magnitude of shear stress required to kill the viable normal cells; and
subsequently applying one or more additional pulses of fluid shear stress to the preparation, said fluid shear stress sufficient to selectively kill the viable normal cells relative to the viable cancerous cells, whereby the ratio of viable cancerous cells to viable normal cells in the preparation is increased.