Patent ID: 11939365
Assignee: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A  G | IPC A  C  G

Claim 15:
16. The protein of claim 15, wherein the protein comprises:
(1) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 33 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 34;
(2) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 43 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 44;
(3) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 53 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 54;
(4) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 63 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 64;
(5) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 73 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 74;
(6) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 83 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 84;
(7) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 93 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 94;
(8) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 103 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 104;
(9) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 113 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 114;
(10) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 123 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 124;
(11) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 133 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 134;
(12) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 143 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 144;
(13) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 153 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 154;
(14) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 163 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 164;
(15) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 173 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 174;
(16) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 183 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 184;
(17) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 193 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 194;
(18) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 203 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 204;
(19) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 213 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 214;
(20) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 223 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 224;
(21) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 233 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 234;
(22) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 243 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 244;
(23) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 253 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 254;
(24) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 263 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 264;
(25) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 273 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 274;
(26) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 283 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 284;
(27) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 293 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 294;
(28) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 303 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 304;
(29) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 313 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 314;
(30) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 323 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 324;
(31) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 333 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 334;
(32) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 343 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 344;
(33) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 353 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 354;
(34) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 363 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 364;
(35) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 373 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 374;
(36) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 383 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 384;
(37) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 393 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 394;
(38) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 403 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 404;
(39) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 413 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 414;
(40) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 423 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 424;
(41) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 433 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 434;
(42) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 443 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 444;
(43) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 453 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 454;
(44) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 463 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 464;
(45) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 483 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 484;
(46) a first polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 493 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to SEQ ID NO: 494
(47) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 21-130 of SEQ ID NO: 33 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-131 of SEQ ID NO: 34;
(48) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-135 of SEQ ID NO: 43 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 20-132 SEQ ID NO: 44;
(49) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 19-127 SEQ ID NO: 53 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 24-134 of SEQ ID NO: 54;
(50) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 21-131 of SEQ ID NO: 63 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-132 of SEQ ID NO: 64;
(51) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 21-131 of SEQ ID NO: 73 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-134 of SEQ ID NO: 74;
(52) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-137 of SEQ ID NO: 83 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-133 of SEQ ID NO: 84;
(53) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-131 of SEQ ID NO: 93 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-134 of SEQ ID NO: 94;
(54) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 21-133 of SEQ ID NO: 103 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-129 of SEQ ID NO: 104;
(55) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 19-126 of SEQ ID NO: 113 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-134 of SEQ ID NO: 114;
(56) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 19-128 of SEQ ID NO: 123 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-134 of SEQ ID NO: 124;
(57) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 19-128 of SEQ ID NO: 133 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-134 of SEQ ID NO: 134;
(58) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 21-130 of SEQ ID NO: 143 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-131 of SEQ ID NO: 144;
(59) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 20-128 of SEQ ID NO: 153 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-132 of SEQ ID NO: 154;
(60) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 21-135 of SEQ ID NO: 163 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-132 of SEQ ID NO: 164;
(61) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 21-133 of SEQ ID NO: 173 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 27-132 of SEQ ID NO: 174;
(62) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 19-129 of SEQ ID NO: 183 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 27-132 of SEQ ID NO: 184;
(63) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-134 of SEQ ID NO: 193 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 20-131 of SEQ ID NO: 194;
(64) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 21-135 of SEQ ID NO: 203 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-134 of SEQ ID NO: 204;
(65) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-136 of SEQ ID NO: 213 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-134 of SEQ ID NO: 214;
(66) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-136 of SEQ ID NO: 223 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-134 of SEQ ID NO: 224;
(67) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-134 of SEQ ID NO: 233 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-140 of SEQ ID NO: 234;
(68) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-134 of SEQ ID NO: 243 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 17-130 of SEQ ID NO: 244;
(69) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 20-125 of SEQ ID NO: 253 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 27-134 of SEQ ID NO: 254;
(70) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 21-135 of SEQ ID NO: 263 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-138 of SEQ ID NO: 264;
(71) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 23-136 of SEQ ID NO: 273 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-141 of SEQ ID NO: 274;
(72) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 23-136 of SEQ ID NO: 283 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 17-131 of SEQ ID NO: 284;
(73) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-135 of SEQ ID NO: 293 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-134 of SEQ ID NO: 294;
(74) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-134 of SEQ ID NO: 303 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-133 of SEQ ID NO: 304;
(75) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 23-134 of SEQ ID NO: 313 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-134 of SEQ ID NO: 314;
(76) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-136 of SEQ ID NO: 323 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-135 of SEQ ID NO: 324;
(77) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 19-125 of SEQ ID NO: 333 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-133 of SEQ ID NO: 334;
(78) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-130 of SEQ ID NO: 343 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-132 of SEQ ID NO: 344;
(79) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-130 of SEQ ID NO: 353 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-134 of SEQ ID NO: 354;
(80) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-130 of SEQ ID NO: 363 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-134 of SEQ ID NO: 364;
(81) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 21-133 of SEQ ID NO: 373 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-125 of SEQ ID NO: 374;
(82) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 20-128 of SEQ ID NO: 383 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 25-132 of SEQ ID NO: 384;
(83) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-131 of SEQ ID NO: 393 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-134 of SEQ ID NO: 394;
(84) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 21-134 of SEQ ID NO: 403 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-134 of SEQ ID NO: 404;
(85) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 21-134 of SEQ ID NO: 413 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-134 of SEQ ID NO: 414;
(86) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 21-134 of SEQ ID NO: 423 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-134 of SEQ ID NO: 424;
(87) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 21-134 of SEQ ID NO: 433 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-134 of SEQ ID NO: 434;
(88) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 21-133 of SEQ ID NO: 443 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-130 of SEQ ID NO: 444;
(89) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 21-133 of SEQ ID NO: 453 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-130 of SEQ ID NO: 454;
(90) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 21-131 of SEQ ID NO: 463 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-140 of SEQ ID NO: 464;
(91) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 21-133 of SEQ ID NO: 483 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-133 of SEQ ID NO: 484; or
(92) a first polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 23-134 of SEQ ID NO: 493 and a second polypeptide chain comprising an amino acid sequence at least 99% identical to amino acids 22-132 of SEQ ID NO: 494.