Patent ID: 11873337
Assignee: KAGOSHIMA UNIVERSITY
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A  G | IPC A  C

Claim 0:
1. An antibody which binds to cell adhesion molecule 3 (CADM3) or an antibody fragment thereof,
wherein the antibody or the antibody fragment thereof is selected from the group consisting of the following (a) to (t):
(a) an antibody in which the amino acid sequences of complementarity determining regions (CDRs) 1 to 3 of a variable domain of a heavy chain (VH) comprise the amino acid sequences represented by SEQ ID NOS: 23, 24, and 25, respectively, and in which the amino acid sequences of CDR1 to CDR3 of a variable domain of a light chain (VL) comprise the amino acid sequences represented by SEQ ID NOS: 28, 29, and 30, respectively;
(b) an antibody in which the amino acid sequences of CDR1 to CDR3 of VH comprise the amino acid sequences represented by SEQ ID NOS: 33, 34 and 35, respectively, and in which the amino acid sequences of CDR1 to CDR3 of VL comprise the amino acid sequences represented by SEQ ID NOS: 38, 39, and 40, respectively;
(c) an antibody fragment in which the amino acid sequences of CDR1 to CDR3 of a variable domain of a heavy chain of a heavy chain antibody (VHH) comprise the amino acid sequences represented by SEQ ID NOS: 3, 4, and 5, respectively;
(d) an antibody fragment in which the amino acid sequences of CDR1 to CDR3 of VHH comprise the amino acid sequences represented by SEQ ID NOS: 8, 9, and 10, respectively;
(e) an antibody fragment in which the amino acid sequences of CDR1 to CDR3 of VHH comprise the amino acid sequences represented by SEQ ID NOS: 13, 14, and 15, respectively;
(f) an antibody fragment in which the amino acid sequences of CDR1 to CDR3 of VHH comprise the amino acid sequences represented by SEQ ID NOS: 18, 19, and 20, respectively;
(g) an antibody in which the amino acid sequences of CDR1 to CDR3 of VH comprise the amino acid sequences represented by SEQ ID NOS: 89, 90, and 91, respectively, and in which the amino acid sequences of CDR1 to CDR3 of VL comprise the amino acid sequences represented by SEQ ID NOS: 94, 95, and 96, respectively;
(h) an antibody in which the amino acid sequences of CDR1 to CDR3 of VH comprise the amino acid sequences represented by SEQ ID NOS: 99, 100, and 101, respectively, and in which the amino acid sequences of CDR1 to CDR3 of VL comprise the amino acid sequences represented by SEQ ID NOS: 134, 135, and 136, respectively;
(i) an antibody in which the amino acid sequences of CDR1 to CDR3 of VH comprise the amino acid sequences represented by SEQ ID NOS: 104, 105, and 106, respectively, and in which the amino acid sequences of CDR1 to CDR3 of VL comprise the amino acid sequences represented by SEQ ID NOS: 134, 135, and 136, respectively;
(j) an antibody in which the amino acid sequences of CDR1 to CDR3 of VH comprise the amino acid sequences represented by SEQ ID NOS: 109, 110, and 111, respectively, and in which the amino acid sequences of CDR1 to CDR3 of VL comprise the amino acid sequences represented by SEQ ID NOS: 134, 135, and 136, respectively;
(k) an antibody in which the amino acid sequences of CDR1 to CDR3 of VH comprise the amino acid sequences represented by SEQ ID NOS: 114, 115, and, 116, respectively, and in which the amino acid sequences of CDR1 to CDR3 of VL comprise the amino acid sequences represented by SEQ ID NOS: 134, 135, and 136, respectively;
(l) an antibody in which the amino acid sequences of CDR1 to CDR3 of VH comprise the amino acid sequences represented by SEQ ID NOS: 119, 120, and 121, respectively, and in which the amino acid sequences of CDR1 to CDR3 of VL comprise the amino acid sequences represented by SEQ ID NOS: 134, 135, and 136, respectively;
(m) an antibody in which the amino acid sequences of CDR1 to CDR3 of VH comprise the amino acid sequences represented by SEQ ID NOS: 124, 125, and 126, respectively, and in which the amino acid sequences of CDR1 to CDR3 of VL comprise the amino acid sequences represented by SEQ ID NOS: 134, 135, and 136, respectively;
(n) an antibody in which the amino acid sequences of CDR1 to CDR3 of VH comprise the amino acid sequences represented by SEQ ID NOS: 129, 130, and 131, respectively, and in which the amino acid sequences of CDR1 to CDR3 of VL comprise the amino acid sequences represented by SEQ ID NOS: 134, 135, and 136, respectively;
(o) an antibody in which the amino acid sequences of CDR1 to CDR3 of VH comprise the amino acid sequences represented by SEQ ID NOS: 139, 140, and 141, respectively, and in which the amino acid sequences of CDR1 to CDR3 of VL comprise the amino acid sequences represented by SEQ ID NOS: 164, 165, and 166, respectively;
(p) an antibody in which the amino acid sequences of CDR1 to CDR3 of VH comprise the amino acid sequences represented by SEQ ID NOS: 144, 145, and 146, respectively, and in which the amino acid sequences of CDR1 to CDR3 of VL comprise the amino acid sequences represented by SEQ ID NOS: 164, 165, and 166, respectively;
(q) an antibody in which the amino acid sequences of CDR1 to CDR3 of VH comprise the amino acid sequences represented by SEQ ID NOS: 149, 150, and 151, respectively, and in which the amino acid sequences of CDR1 to CDR3 of VL comprise the amino acid sequences represented by SEQ ID NOS: 164, 165, and 166, respectively;
(r) an antibody in which the amino acid sequences of CDR1 to CDR3 of VH comprise the amino acid sequences represented by SEQ ID NOS: 154, 155, and 156, respectively, and in which the amino acid sequences of CDR1 to CDR3 of VL comprise the amino acid sequences represented by SEQ ID NOS: 164, 165, and 166, respectively;
(s) an antibody in which the amino acid sequences of CDR1 to CDR3 of VH comprise the amino acid sequences represented by SEQ ID NOS: 159, 160, and 161, respectively, and in which the amino acid sequences of CDR1 to CDR3 of VL comprise the amino acid sequences represented by SEQ ID NOS: 164, 165, and 166, respectively; and
(t) an antibody in which the amino acid sequences of CDR1 to CDR3 of VH comprise the amino acid sequences represented by SEQ ID NOS: 169, 170, and 171, respectively, and in which the amino acid sequences of CDR1 to CDR3 of VL comprise the amino acid sequences represented by SEQ ID NOS: 174, 175, and 176, respectively.