Patent ID: 11939365
Assignee: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A  G | IPC A  C  G

Claim 14:
15. An isolated or purified protein having antigenic specificity for mutated human p53, wherein the mutated human p53 has one of the following human p53 mutations: R175H, Y220C, G245S, R248Q, or R248W, wherein the human p53 mutations are defined by reference to SEQ ID NO: 1, and wherein the protein comprises an amino acid sequence at least 97% identical to SEQ ID NO: 23 or 24, an amino acid sequence at least 97% identical to SEQ ID NO: 25, and:
(1) a first polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 27-29 and a second polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 30-32;
(2) a first polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 37-39 and a second polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 40-42;
(3) a first polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 47-49 and a second polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 50-52;
(4) a first polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 57-59 and a second polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 60-62;
(5) a first polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 67-69 and a second polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 70-72;
(6) a first polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 77-79 and a second polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 80-82;
(7) a first polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 87-89 and a second polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 90-92;
(8) a first polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 97-99 and a second polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 100-102;
(9) a first polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 107-109 and a second polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 110-112;
(10) a first polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 117-119 and a second polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 120-122;
(11) a first polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 127-129 and a second polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 130-132;
(12) a first polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 137-139 and a second polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 140-142;
(13) a first polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 147-149 and a second polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 150-152;
(14) a first polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 157-159 and a second polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 160-162;
(15) a first polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 167-169 and a second polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 170-172;
(16) a first polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 177-179 and a second polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 180-182;
(17) a first polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 187-189 and a second polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 190-192;
(18) a first polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 197-199 and a second polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 200-202;
(19) a first polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 207-209 and a second polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 210-212;
(20) a first polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 217-219 and a second polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 220-222;
(21) a first polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 227-229 and a second polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 230-232;
(22) a first polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 237-239 and a second polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 240-242;
(23) a first polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 247-249 and a second polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 250-252;
(24) a first polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 257-259 and a second polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 260-262;
(25) a first polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 267-269 and a second polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 270-272;
(26) a first polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 277-279 and a second polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 280-282;
(27) a first polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 287-289 and a second polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 290-292;
(28) a first polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 297-299 and a second polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 300-302;
(29) a first polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 307-309 and a second polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 310-312;
(30) a first polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 317-319 and a second polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 320-322;
(31) a first polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 327-329 and a second polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 330-332;
(32) a first polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 337-339 and a second polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 340-342;
(33) a first polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 347-349 and a second polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 350-352;
(34) a first polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 357-359 and a second polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 360-362;
(35) a first polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 367-369 and a second polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 370-372;
(36) a first polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 377-379 and a second polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 380-382;
(37) a first polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 387-389 and a second polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 390-392;
(38) a first polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 397-399 and a second polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 400-402;
(39) a first polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 407-409 and a second polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 410-412;
(40) a first polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 417-419 and a second polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 420-422;
(41) a first polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 427-429 and a second polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 430-432;
(42) a first polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 437-439 and a second polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 440-442;
(43) a first polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 447-449 and a second polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 450-452;
(44) a first polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 457-459 and a second polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 460-462;
(45) a first polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 477-479 and a second polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 480-482; or
(46) a first polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 487-489 and a second polypeptide chain comprising the amino acid sequences of all of SEQ ID NOs: 490-492.