Patent ID: 11873318
Assignee: SHANGHAI STA PHARMACEUTICAL R&D CO., LTD.
Field: Measurement (Instruments)
Classification: CPC C  G | IPC C

Claim 4:
5. A method of synthesizing an oligonucleotide, comprising:
a) preparing or having prepared a substantially pure dichloroacetic acid having less than 50 ppm glyoxylic acid; and
b) mixing the substantially pure dichloroacetic acid with a protected oligonucleotide having an acid labile protecting group under conditions suitable to remove the acid labile protecting group, thereby producing a deprotected oligonucleotide
wherein the substantially pure dichloroacetic acid is prepared from a starting dichloroacetic acid composition having glyoxylic acid by reducing the level of glyoxylic acid to less than 50 ppm.