Patent ID: 11939325
Assignee: MAKSCIENTIFIC, LLC
Field: Organic fine chemistry (Chemistry)
Classification: CPC C | IPC C

Claim 0:
1. A process for preparing a compound represented by Formula IA, its solvates, polymorphs and isotopic variations thereof:, , comprising:
reacting a compound represented by Formula II:, , with a compound represented by Formula III:, , to provide a compound represented by Formula VII:, , and
reacting the compound of Formula VII with an alkyne to provide a compound represented by formula I:, , or
reacting a compound represented by Formula II:, , with a compound represented by Formula III:, , to provide a compound represented by Formula I:, , and
reacting the compound of Formula I with an alkali metal hydroxide to provide a compound represented by Formula V:, , and
reacting the compound of Formula V with a substituted hydrazine to provide a compound represented by the Formula IA; or
reacting the compound of Formula I with a substituted hydrazine to provide a compound represented by Formula VI:, , and
reacting the compound of Formula VI with a divinyl derivative to provide a compound represented by the Formula IA, wherein
R is selected from the group consisting of H, CH3 and CH2CH3;
R1 is selected from the group consisting of H, CN, OH, phthalimido, amide, carboxylic ester, nitrate ester, halogen, methoxy, mesylate and tosylate;
R2 is selected from the group consisting of H, CH3, CH2CH3, OCH3 and CN;
X1 is selected from the group consisting of CH2, O and SO2;
X2 is halogen or, n is an integer from 1-4; and
Y is selected from the group consisting of a C1-C4 alkyl group, a C1-C4 perfluoroalkyl group, and a phenyl group that is unsubstituted or substituted with a methyl, chloro or nitro group.