Patent ID: 11912992
Assignee: ARBOR BIOTECHNOLOGIES, INC.
Field: Biotechnology (Chemistry)
Classification: CPC C | IPC C

Claim 2:
3. The system of claim 1, wherein the CRISPR-Cas effector protein comprises one or more of:
(a) a RuvC domain comprising the amino acid sequence X1SHX4DX6X7 (SEQ ID NO: 200, wherein X1 is S or T, X4 is Q or L, X6 is P or S, and X7 is F or L,
(b) a RuvC domain comprising the amino acid sequence X1XDXNX6X7XXXX11 (SEQ ID NO: 201), wherein X1 is A, G, or S, X is any amino acid, X6 is Q or I, X7 is T, S, or V, and X11 is T or A; and
(c) a RuvC domain comprising the amino acid sequence X1X2X3 E (SEQ ID NO: 210), wherein X1 is C, F, I, L, M, P, V, W, or Y, X2 is C, F, I, L, M, P, R, V, W, or Y, and X3 is C, F, G, I, L, M, P, V, W, or Y.