Patent ID: 11952424
Assignee: MERUS N.V.
Field: Biotechnology (Chemistry)
Classification: CPC C  A | IPC C

Claim 0:
1. A multivalent antibody which comprises:
a base antibody portion which comprises two binding domains; and
one or two additional binding domains,
wherein the base antibody portion is a full length immunoglobulin,
wherein the one or two additional binding domains are Fab domains comprising a CH1 region, each Fab domain being connected to the base antibody portion by a linker, linking a variable region of the base antibody portion and the CH1 region,
wherein each binding domain of the base antibody portion and each of the one or two additional binding domains all have the same light chain, the light chain comprising the complementarity determining regions (CDRs) of IGKV1-39/jk1 or IGKV1-39/jk5, and
wherein the multivalent antibody binds to at least three different epitopes or antigens.