Patent ID: 11932654
Assignee: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH
Field: Organic fine chemistry (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A nimbolide analog of formula I and a pharmaceutically acceptable salt thereof:, , wherein, ring M is a ring selected from the group consisting of substituted or unsubstituted aryl, heteroaryl, cycloalkyl and heterocyclic; and
(i) when A and B are each independently selected from the group consisting of C, N, and S, then R1, R2, R3, R4, R5 and R6 are each independently selected from the group consisting of C1-C6 alkyl, aryl, heteroaryl, C3-C7 cycloalkyl, heteroalkyl, hydrogen, hydroxy, alkoxy, nitro, halogen, amino, alkylamino, aryl amino and cyano, wherein each of the C1-C6 alkyl, aryl, heteroaryl, C3-C7 cycloalkyl, heteroalkyl, alkoxy, amino, alkylamino, and aryl amino is optionally substituted with one or more substituents selected from the group consisting of hydroxy, halogen, cyano, alkyl amino, aryl amino, alkoxy, amino, nitro, aldehyde, carboxylic acid and ester;
(ii) when A and/or B is O, then R1, R2, and R3 are each independently selected from the group consisting of C1-C6 alkyl, aryl, heteroaryl, C3-C7 cycloalkyl, heteroalkyl, hydrogen, hydroxy, alkoxy, nitro, halogen, amino, alkylamino, aryl amino and cyano, wherein each of the C1-C6 alkyl, aryl, heteroaryl, C3-C7 cycloalkyl, heteroalkyl, alkoxy, amino, alkylamino, and aryl amino is optionally substituted with one or more substituents selected from the group consisting of hydroxy, halogen, cyano, alkyl amino, aryl amino, alkoxy, amino, nitro, aldehyde, carboxylic acid and ester;
(iii) when A is O, then R4 and R5 are not present; and
(iv) when B is O, then R6 is not present; and
wherein the dashed bond line in formula I indicates the presence of either a single or double bond.