Patent ID: 11931966
Assignee: CELLINK BIOPRINTING AB
Field: Other special machines (Mechanical engineering)
Classification: CPC B  G | IPC B  G

Claim 18:
19. A 3D bioprinter comprising:
(a) one or more printheads and one or more optical imaging apparatus disposed on one or more of the printheads in a manner such that the optical imaging apparatus is positioned to the side, above, and/or below a nozzle and is capable of capturing images or video of bioink dispensed from the nozzle during printing;
(b) one or more control element;
(c) one or more processor and communication interface operably connecting and capable of communicating printability data from the one or more optical imaging apparatus to the one or more control element to control printing of a printed structure; and
(d) a non-transitory computer-readable storage media comprising:
(1) one or more process algorithms capable of quantifying printing characteristics chosen from one or more of shape, uniformity, thickness, size, and/or color of droplets or filaments of the bioink disposed from the nozzle from one or more images and/or video obtained with the optical imaging apparatus; and
(2) one or more learning algorithms capable of i) calibrating a bioink and ii) modifying and adjusting printing instructions and/or printing parameters based on one or more printability metrics to achieve a second printed structure.