Patent ID: 11964051
Assignee: TRANSLATE BIO, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 0:
1. A cationic lipid having a structure according to Formula (II),, , wherein
RA is -L1-R1, RB is -L2-R2, and RC is -L3-R3; RA is hydrogen, RB is -L2-R2 and RC -L3-R3; RA is -L1-R1, RB is hydrogen, and RC is -L3-R3; or RA is -L1-R1, RB is -L2-R2, and RC is hydrogen;
each of L1, L2, and L3 is independently a covalent bond, —C(O)—, —C(O)O—, —C(O)S—, or —C(O)NRL—;
L4 is independently C1-C10 alkylene;
each R1, R2, and R3 is independently C6-C30 alkyl, C6-C30 alkenyl, or C6-C30 alkynyl;
each R4 and R5 is independently hydrogen, unsubstituted C1-C10 alkyl; unsubstituted C2-C10 alkenyl; or unsubstituted C2-C10 alkynyl; or R4 and R5 combine to form a 5- to 10-membered heterocyclyl or a 5- to 10-membered heteroaryl;
each RL is independently hydrogen, C1-C20 alkyl, C2-C20 alkenyl, or C2-C20 alkynyl.