Patent ID: 11939356
Assignee: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 0:
1. A recombinant insect ferritin nanoparticle, comprising:
twelve recombinant ferritin heavy chains and twelve recombinant ferritin light chains self-assembled into a globular ferritin nanoparticle; wherein
(A)
the recombinant insect ferritin heavy chains consist of 172 to 174 amino acids from the C-terminus of an insect ferritin heavy chain;
the recombinant insect ferritin light chains consist of 182 to 184 amino acids or 177 amino acids from the C-terminus of an insect ferritin light chain; and
each of the ferritin heavy and light chains is fused N terminally to a viral protein; and
(B)
the recombinant ferritin heavy chains consist of an amino acid sequence at least 90% identical to SEQ ID NO: 2; and the recombinant ferritin light chains consist of an amino acid sequence at least 90% identical to SEQ ID NO: 6; or
the recombinant ferritin heavy chains each consist of an amino acid sequence at least 90% identical to SEQ ID NO: 4; and the recombinant ferritin light chains each consist of an amino acid sequence at least 90% identical to SEQ ID NO: 8.