Patent ID: 11913950
Assignee: AUGUREX LIFE SCIENCES CORP.
Field: Measurement (Instruments)
Classification: CPC G  C | IPC C  G

Claim 0:
1. A autoantibodies against a citrullinated 14-3-3 protein or fragment thereof in a subject comprising
i) obtaining a biological sample from a subject suspected of having or at risk for developing rheumatoid arthritis, ankylosing spondylitis, systemic lupus erythematosus, and psoriatic arthritis;
ii) contacting said biological sample from said subject with at least one citrullinated 14-3-3 protein or fragment thereof under a condition suitable for the formation of at least one immune complex between the citrullinated 14-3-3 protein or fragment thereof and autoantibodies against the citrullinated 14-3-3 protein or fragment thereof that may be present in the biological sample; and
iii) detecting the presence of immune complexes between the citrullinated 14-3-3 protein or fragment thereof and autoantibodies against the citrullinated 14-3-3 protein or fragment thereof;
wherein the citrullinated 14-3-3 protein or fragment thereof comprises a citrulline residue at a position selected from the group consisting of position 4, position 12, position 19, position 42, position 61, position 86 and position 227 of SEQ ID NO: 5; or comprises an amino acid sequence selected from the group consisting of SEQ ID NOs: 16-22.