Patent ID: 11890342
Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 0:
1. A method for producing a linear block copolymer, comprising:
preparing an alcohol terminated polyethylene glycol (PEG) material having an acetal group, the preparation comprising:
reacting an alcohol terminated PEG with 2-(vinyloxy)ethyl acetate to form an acetate terminated PEG having the acetal group, and
hydrolyzing the acetate terminated PEG having the acetal group to form the alcohol terminated PEG material having the acetal group;

introducing the alcohol terminated PEG having the acetal group with a cyclic carbonate monomer; and
mixing the alcohol terminated PEG having the acetal group, the cyclic carbonate monomer, and a base to form a linear block copolymer, wherein the linear block copolymer consists of a hydrophilic block comprising a polyethylene glycol, a hydrophobic block having a structure comprising a carbonate group, and a stimulus-responsive junction moiety having the structure, , wherein one wavy bond represents a bond to the polyethylene glycol of the hydrophilic block and the other wavy bond represents a bond to the carbonate group of the hydrophobic block.