Patent ID: 11904029
Assignee: UNIVERSITY OF VIRGINIA PATENT FOUNDATION
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 0:
1. An imageable microsphere, comprising:
at least one imageable radioisotope; and
a substrate comprising an inorganic material that comprises metalloid or metal atoms bonded to non-metal atoms, the substrate comprising:
a core extending to a surface, the core comprising a first portion of the metalloid or metal atoms bonded to the non-metal atoms and the surface comprising a second portion of the metalloid or metal atoms bonded to the nonmetal atoms;
wherein the at least one imageable radioisotope is bound directly to the substrate through non-metal atoms of the surface of the substrate and/or wherein the at least one imageable radioisotope is bound to the substrate through an inorganic bridge comprising nonmetal atoms of the surface of the substrate;
wherein the at least one imageable radioisotope is selected from 99mTc, 201Th, 51Cr, 67Ga, 68Ga, 111In, 64Cu, 89Zr, 59Fe, 42K, 82Rb, 24Na, 45Ti, 44Sc, 51Cr, 18F, 177Lu, Al18F, and/or combinations thereof; and
wherein the substrate comprises silicon dioxide and at least one other element selected from manganese, aluminum, gallium, yttrium, boron, strontium, and titanium.