Patent ID: 11884735
Assignee: TENEOBIO, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A heavy chain-only antibody comprising:
a first heavy chain variable region that binds to IL2RB, comprising:
a CDR1 sequence comprising the formula:
G G S I S S S X1 W (SEQ ID NO: 26)

wherein X1 is D or N; and
a CDR2 sequence comprising the formula:
I X2 H S G S T (SEQ ID NO: 27)

wherein X2 is D or S; and
a CDR3 sequence comprising the formula:
X3 R G X4 W E L X5 D A F D I (SEQ ID NO: 28)

wherein X3 is G or A;
X4 is S or Q; and
X5 is S or T; and

a second heavy chain variable region that binds to IL2RG, comprising:
a CDR1 sequence comprising the formula:
G F X1 X2 X3 X4 Y Y (SEQ ID NO: 32)

wherein X1 is T or I;
X2 is F or V;
X3 is S, N, or G; and
X4 is D or N; and
a CDR2 sequence comprising the formula:
I S X5 S G X6 X7 I (SEQ ID NO: 33)

wherein X5 is S or N;
X6 is D, S, G, or N; and
X7 is T or I; and
a CDR3 sequence comprising the sequence ARGDAVSITGDY (SEQ ID NO: 20).