Patent ID: 11905257
Assignee: BRACCO IMAGING S.P.A.
Field: Organic fine chemistry (Chemistry)
Classification: CPC C | IPC C

Claim 0:
1. A process for preparing Gadoteridol of formula (I):, comprising the steps:
i) preparing propylene oxide by decomposition of propylene carbonate of formula:, in the presence of an alkaline or alkaline earth metal halide as catalyst and directly reacting propylene oxide of formula:, with the compound of formula (II) without being isolated:, , wherein M is an alkaline or alkaline earth metal and n is 1 or 2;
to obtain the compound of formula (III):, , wherein M and n are as defined above;
ii) complexing the obtained compound of formula (III) with Gd3+ metal ion to obtain Gadoteridol of formula (I).