Patent ID: 11951131
Assignee: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 14:
15. A nucleic acid comprising:
(a) a suicide gene; and
(b) a nucleotide sequence encoding a chimeric antigen receptor (CAR), wherein the CAR comprises a single chain comprising, from the N-terminus to the C-terminus: a CD8α signal sequence, an antigen recognition domain, a human CD8 α hinge and transmembrane domain, a cytoplasmic portion of human CD28, and a cytoplasmic portion of human CD3ζ,
wherein the CAR has antigenic specificity for signaling lymphocyte activating molecule F7 (SLAM F7),
wherein the antigen recognition domain comprises the amino acid sequences of SEQ ID NOs: 1-6;
wherein the nucleotide sequence encoding the CAR is positioned 3′ of the suicide gene, and wherein the suicide gene is an inducible caspase 9 (IC9) gene.