Patent ID: 11919908
Assignee: INCYTE CORPORATION
Field: Organic fine chemistry (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 32:
33. The compound of claim 1, which is selected from:
4-(2-amino-4-oxo-5-(3-tolyl)-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)-N,N-dimethylbenzenesulfonamide;
4-(2-amino-5-(benzofuran-7-yl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)-N,N-dimethylbenzenesulfonamide;
4-(2-amino-5-(3-(hydroxymethyl)phenyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)-N,N-dimethylbenzenesulfonamide;
4-(2-amino-5-(2-chlorophenyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)-N,N-dimethylbenzenesulfonamide;
4-(2-amino-5-(3-isopropylphenyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)-N,N-dimethylbenzenesulfonamide;
4-(2-amino-5-(2,3-dihydrobenzo[b][1,4]dioxin-5-yl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)-N,N-dimethylbenzenesulfonamide;
4-(2-amino-5-(4-(1-methylpiperidin-4-yl)phenyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)-N,N-dimethylbenzenesulfonamide;
4-(2-amino-5-(4-(difluoromethyl)phenyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)-N,N-dimethylbenzenesulfonamide;
4-(2-amino-5-(chroman-8-yl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)-N,N-dimethylbenzenesulfonamide;
4-(2-amino-6-(4-(N,N-dimethylsulfamoyl)phenyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-methylbenzamide;
4-(2-amino-5-(2,2-difluorobenzo[d][1,3]dioxol-4-yl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)-N,N-dimethylbenzenesulfonamide;
4-(2-amino-5-(4-(methylsulfonyl)phenyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)-N,N-dimethylbenzenesulfonamide;
3-(2-amino-6-(4-(N,N-dimethylsulfamoyl)phenyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)benzamide;
4-(2-amino-5-(2-(cyanomethyl)phenyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)-N,N-dimethylbenzenesulfonamide;
4-(2-amino-5-(1-methyl-1H-indazol-4-yl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)-N,N-dimethylbenzenesulfonamide;
4-(2-amino-5-(3-cyanophenyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)-N,N-dimethylbenzenesulfonamide;
4-(2-amino-5-(2-cyanophenyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)-N,N-dimethylbenzenesulfonamide;
4-(2-amino-5-(2-(difluoromethoxy)phenyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)-N,N-dimethylbenzenesulfonamide;
4-(2-amino-5-(1H-indazol-7-yl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)-N,N-dimethylbenzenesulfonamide;
4-(2-amino-4-oxo-5-(1-oxo-1,2,3,4-tetrahydroisoquinolin-6-yl)-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)-N,N-dimethylbenzenesulfonamide;
4-(2-amino-5-(4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)-N,N-dimethylbenzenesulfonamide;
4-(2-amino-6-(4-(N,N-dimethylsulfamoyl)phenyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)-3-methoxybenzamide;
4-(2-amino-5-(2-methoxy-5-(trifluoromethyl)phenyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)-N,N-dimethylbenzenesulfonamide;
4-(2-amino-5-(2,5-dimethoxyphenyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)-N,N-dimethylbenzenesulfonamide;
4-(2-amino-5-(2,3-dihydrobenzofuran-6-yl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)-N,N-dimethylbenzenesulfonamide;
4-(2-amino-5-(5-chloro-2-methoxyphenyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)-N,N-dimethylbenzenesulfonamide;
4-(2-amino-4-oxo-5-(1-(pyridin-3-ylmethyl)-1H-pyrazol-4-yl)-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)-N,N-dimethylbenzenesulfonamide;
4-(2-amino-5-(1-benzyl-1H-pyrazol-4-yl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)-N,N-dimethylbenzenesulfonamide;
4-(2-amino-5-(1-(4-cyanobenzyl)-1H-pyrazol-4-yl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)-N,N-dimethylbenzenesulfonamide;
4-(2-amino-4-oxo-5-(1-(pyridin-4-ylmethyl)-1H-pyrazol-4-yl)-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)-N,N-dimethylbenzenesulfonamide;
4-(2-amino-5-(3-methoxynaphthalen-2-yl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)-N,N-dimethylbenzenesulfonamide;
3-(2-amino-6-(4-(N,N-dimethylsulfamoyl)phenyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)benzoic acid;
4-(2-amino-6-(4-(N,N-dimethylsulfamoyl)phenyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)benzoic acid;
4-(2-amino-5-(1-(1,1-dioxidotetrahydrothiophen-3-yl)-1H-pyrazol-4-yl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)-N,N-dimethylbenzenesulfonamide;
4-(2-amino-4-oxo-5-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)-N,N-dimethylbenzenesulfonamide;
4-(2-amino-4-oxo-5-phenyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)-N,N-dimethylbenzenesulfonamide;
4-(2-amino-5-(4-cyanophenyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)-N,N-dimethylbenzenesulfonamide;
4-(2-amino-5-(3-chloro-2-methoxyphenyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)-N,N-dimethylbenzenesulfonamide;
4-(2-amino-5-(2,3-dihydrobenzofuran-7-yl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)-N,N-dimethylbenzenesulfonamide;
4-(2-amino-5-(2,4-dimethoxyphenyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)-N,N-dimethylbenzenesulfonamide;
4-(2-amino-5-(2,3-dimethoxyphenyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)-N,N-dimethylbenzenesulfonamide;
4-(2-amino-5-(benzo[d][1,3]dioxol-4-yl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)-N,N-dimethylbenzenesulfonamide;
4-(2-amino-5-(3-(aminomethyl)phenyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)-N,N-dimethylbenzenesulfonamide;
4-(2-amino-5-(1-methyl-1H-pyrazol-5-yl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)-N,N-dimethylbenzenesulfonamide;
4-(2-amino-5-(cyclopent-1-en-1-yl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)-N,N-dimethylbenzenesulfonamide;
4-(2-amino-4-oxo-5-(3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-8-yl)-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)-N,N-dimethylbenzenesulfonamide;
4-(2-amino-5-(3,4-dihydro-2H-benzo[b][1,4]oxazin-8-yl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)-N,N-dimethylbenzenesulfonamide;
4-((4-(2-amino-6-(4-(N,N-dimethylsulfamoyl)phenyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)-3-methoxy-1H-pyrazol-1-yl)methyl)benzoic acid;
3-((4-(2-amino-6-(4-(N,N-dimethylsulfamoyl)phenyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)-1H-pyrazol-1-yl)methyl)benzoic acid;
4-((4-(2-amino-6-(4-(N,N-dimethylsulfamoyl)phenyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)-1H-pyrazol-1-yl)methyl)benzoic acid;
2-amino-5-(2-methoxyphenyl)-6-(4-((4-(methylsulfonyl)piperidin-1-yl)methyl)phenyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one;
2-amino-5-(2-methoxyphenyl)-6-(4-(morpholine-4-carbonyl)phenyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one;
4-(2-amino-5-(2-methoxyphenyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)-N,N-dimethylbenzamide;
4-(2-amino-4-oxo-5-(3-tolyl)-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)-N,N-dimethylbenzamide;
3-(2-amino-4-oxo-5-(3-tolyl)-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)-N,N-dimethylbenzamide;
4-(2-amino-5-(2-fluorophenyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)-N,N-dimethylbenzenesulfonamide;
4-(2-amino-5-(2-methoxyphenyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)-N,N-dimethylbenzenesulfonamide;
4-(2-amino-5-(2-methoxy-5-methylphenyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)-N,N-dimethylbenzenesulfonamide;
4-(2-amino-5-(2-fluoro-3-methylphenyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)-N,N-dimethylbenzenesulfonamide;
4-(2-amino-5-(2-fluoro-6-methoxyphenyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)-N,N-dimethylbenzenesulfonamide;
4-(2-amino-5-(2-fluoro-5-methylphenyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)-N,N-dimethylbenzenesulfonamide;
4-(2-amino-5-(2-ethoxyphenyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)-N,N-dimethylbenzenesulfonamide; and
4-(2-amino-5-(2,2-dimethyl-2,3-dihydrobenzofuran-7-yl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)-N,N-dimethylbenzenesulfonamide;
or a pharmaceutically acceptable salt thereof.