Patent ID: 11884687
Assignee: HOVIONE SCIENTIA LIMITED
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 18:
19. A multifunctional compound comprising a tripodal boranated core, wherein the multifunctional compound further comprises:
(a) at least one therapeutically useful cargo molecule, or a residue thereof;
(b) at least one water-soluble moiety or a residue of a water-soluble molecule; and at least one of components (c) or (d), wherein
(c) is at least one functionalizing moiety capable of being post-functionalised with a targeting unit or a residue of a targeting molecule; and
(d) is at least one targeting unit or a residue of a targeting molecule;
in which any residue of a molecule is such that, on breaking at least one covalent bond of the multifunctional compound, the complete molecule is released; and
wherein the tripodal boronated core is as defined in the general formula:, wherein:
R1 is H, Cn=1-6 alkyl or phenyl;
R2 is H;
R3 is a residue of a water-soluble moiety and/or a functionalising moiety and/or a targeting moiety and the residue of a water-soluble moiety and/or a functionalising moiety and/or a targeting moiety is Rx-[—O—(—CH2)2-]3—O— in which Rx is a C1-6 alkyl chain;
R4 is H or alkoxy;
R5 and R6 are H;
R7 is H, or is or includes the residue of a therapeutically useful cargo water-soluble moiety and/or a functionalising moiety and/or a targeting moiety;
R8 and R9 are both H;
R10 is phenyl, or the residue of a therapeutically useful cargo or a residue of an API; and
X and/or Y is O.