Patent ID: 11918694
Assignee: SOANE PHARMA LLC
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 0:
1. A method of delivering a therapeutic agent into an intestine of a mammal, comprising:
orally administering an orally ingestible delivery system (OIDS) to the mammal, wherein the OIDS comprises a therapeutic agent and a differentially permeable capsule system, wherein the therapeutic agent is contained within a therapeutic agent compartment;
wherein the differentially permeable capsule system comprises an acid-resistant protease-digestible membrane and a gas-producing substance;
wherein the acid-resistant protease-digestible membrane comprises an inner protease-digestible layer and an outer acid-resistant layer,
wherein the inner protease-digestible layer surrounds the therapeutic agent compartment;
wherein the outer acid-resistant layer is perforated by a system of pores providing fluid communication between the external surface of the acid-resistant protease-digestible membrane and the inner protease-digestible layer, and wherein the gas-producing substance is contained within the system of pores;
wherein the OIDS passes into the stomach of the mammal after the oral administration,
and the gas-producing substance reacts with stomach acid to form a dispersible acid barrier, wherein the dispersible acid barrier is a gas and is formed within the pores and on the exterior surface of the outer acid-resistant layer, and wherein the dispersible acid barrier inhibits contact between the acid-resistant protease-digestible membrane and the gastric juice of the stomach; and
wherein the gas-producing substance is a carbonate and wherein the gas is carbon dioxide;
and
wherein the OIDS comprising the dispersible acid barrier passes into the intestine,
wherein the dispersible acid barrier is dispersed by interaction of the carbon dioxide with bicarbonate in the intestine, and the intestinal fluids penetrate the acid-resistant protease-digestible membrane following the dispersal of the dispersible acid barrier to release the therapeutic agent from the therapeutic agent compartment;
thereby delivering the therapeutic agent to the intestine.