Patent ID: 11918660
Assignee: KRYSTAL BIOTECH, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 0:
1. A pharmaceutical composition comprising:
(a) a herpes simplex virus type 1 (HSV-1) comprising a recombinant HSV-1 genome, wherein the recombinant HSV-1 genome comprises a polynucleotide encoding an Interleukin (IL)-2 polypeptide and a polynucleotide encoding an IL-12 polypeptide; and
(b) a pharmaceutically acceptable excipient,
wherein the IL-12 polypeptide comprises an IL-12 subunit alpha polypeptide and an IL-12 subunit beta polypeptide connected by a linker polypeptide, and
wherein the recombinant HSV-1 genome further comprises a first promoter operably linked to the polynucleotide encoding the IL-2 polypeptide and a second promoter operably linked to the polynucleotide encoding the IL-12 polypeptide.