Patent ID: 11891645
Assignee: NOVOZYMES A/S
Field: Biotechnology (Chemistry)
Classification: CPC C | IPC C

Claim 12:
13. The variant of claim 10, comprising at least one substitution selected from the group consisting of: G20L, G20R, T27S, S29A, S29C, S29L, S29N, S29P, S29R, A34L, A34N, A34R, F42Y, K45L, K45Y, A46E, A46K, S50A, S50L, A53L, Q54L, F55R, I59M, I59P, S60E, S60P, S61D, S61P, S62N, S66M, S66T, T69C, D76A, D76G, D76K, D76L, D76N, D76P, D76V, D76Y, E81S, N87F, T93S, L96F, L96S, L96T, T98L, P101F, P101L, P101M, P101R, T102C, T102I, T103V, D109P, D110W, N115A, N115D, N115G, N115P, E117D, E117F, E117G, E117L, E117N, E117P, E117S, E117W, E117Y, N124D, N124I, N124K, N124L, N124M, N124T, N124V, F125K, F125L, F125M, L1270, L127P, G128N, G128R, G128S, G128W, G128Y, S130D, S130F, S130I, S130N, L1360, G141A, G1410, G141F, G141L, G141M, G141Q, G141R, G141V, Q142A, Q142L, Q142M, Q142S, Q142W, N145F, N145G, N145I, N145L, N145P, N145R, N145S, N145V, N145W, T146A, T1460, T146H, T146I, T146M, T146N, T146Q, T146R, T146V, T146W, S148G, A149V, K150F, N153Y, Q154I, Q154K, Q154L, Q154M, Q154R, Q154W, N157F, N157Y, Y159H, Y159S, Q161A, T167D, Q182F, A184F, A184I, A184K, A184V, A184W, H185A, N188L, F199L, M200F, M200L, Q207F, G208H, G208Y, V209F, V209G, V209H, V209L, V209N, V209W, V209Y, S210E, S210L, S210R, S210T, S210Y, P211F, T213F, T213I, T213L, T213N, T213R, T213S, T213W, A216F, S219M, I228F, I228H, I228L, I228M, I228Q, I228V, I228Y, Y231F, Y231S, S237F, S237I, S237K, S237L, G244N, G249C, N252F, V261A, V261G, V266C, V266R, D267S, S272I, S272L, S272M, S272Q, S272R, S272T, S272Y, Q275F, Q275K, Q275L, Q275R, Q275V, T276F, T276R, T276V, I277L, I277V, D280F, D280H, D280M, D280N, D280S, D280T, A285S, T288C, T288V, I293Y, S294T, S294V, A303F, G304H, G304K, G304P, G304R, G304S, K3050, K305F, K305H, K305I, K305S, K305T, S306L, S306R, P307C, L308P, L308T, F310M, F310P, F310Y, S317A, S317C, S317G, S317H, S317I, S317K, S317L, S317R, S317W, S317Y, S318N, S318R, A319F, A319W, K321R, K321S, D326P, V327C, V327T, S336R, N338H, N338S, N338T, P341I, P341N, P341R, A344K, A344L, A344P, G345K, G345S, P348G, P348L, P348S, N356L, N356Y, A358L, K359S, K359W, L361P, L361R, T362C, T362H, T362I, T362K, T362M, T362R, T362Y, A363F, and V364M, wherein the substitution at the one or more positions provides a protease variant having an increase in specific activity measured as improvement factor, AIF, of at least 2.0.