Patent ID: 11932633
Assignee: ARRAY BIOPHARMA INC.
Field: Organic fine chemistry (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A compound of formula I:, or a pharmaceutically acceptable salt or solvate thereof, wherein:
R1 is —C(O)C(RA)C(RB)p or —SO2C(RA)C(RB)p;
L1 is a bond or (CH2)qCR2R3(CH2)t—, wherein q and t are each independently 0, 1, 2, or 3 and q+t is equal to or less than 3;
R2 and R3 are each independently hydrogen, cyano, C3-C4 cycloalkyl, or C1-C3 alkyl, wherein the C1-C3 alkyl may be optionally substituted with cyano or —OR10; or R2 and R3 together with the carbon atom to which they are attached form a C3-C4 cycloalkyl;
each R4 is independently cyano, C1-C3 alkyl, C1-C3 alkoxy, halogen, haloalkyl, aryl, or heteroaryl, wherein the aryl and heteroaryl may be optionally substituted with one or more R7;
R5 is hydrogen, cycloalkyl, heterocyclyl, aryl, aralkyl or heteroaryl, wherein each of the cycloalkyl, heterocyclyl, aryl, aralkyl and heteroaryl may be optionally substituted with one or more R7;
Z is O or S;
R6 is hydrogen, alkyl, hydroxyalkyl, dihydroxyalkyl, alkylaminylalkyl, dialkylaminylalkyl, —W—NR10R11, —W—C(═O)NR10R11, heterocyclyl, heterocyclylalkyl, aryl, heteroaryl, or heteroarylalkyl, wherein each of the heterocyclyl, heterocyclylalkyl, aryl, heteroaryl, and heteroarylalkyl may be optionally substituted with one or more R8;
W is C1-C5 alkylene;
each R7 is independently halogen, hydroxyl, alkyl, cycloalkyl, alkoxy, haloalkyl, haloalkyloxy, amino, alkylaminyl, cyano or hydroxyalkyl;
each R8 is independently acyl, hydroxyl, hydroxyalkyl, cyano, halogen, alkyl, cycloalkyl, alkoxy, heteroalkyl, or dialkylaminyl;
R9 is hydrogen, hydroxyl, cyano, halogen, haloalkyl, or alkyl;
each R10 is independently hydrogen or C1-C3 alkyl;
each R11 is independently hydrogen, acyl, alkyl, heteroalkyl or hydroxyalkyl;
m is 0, 1, 2, or 3;
RA is absent, hydrogen, or C1-C3 alkyl;
each RB is independently hydrogen, C1-C3 alkyl, alkylaminylalkyl or dialkylaminylalkyl;
p is one or two; and wherein,
when is a triple bond then RA is absent, RB is present and p equals one, or when is a double bond then RA is present, RB is present and p equals two, or RA, RB and the carbon atoms to which they are attached form a 5-8 membered partially saturated cycloalkyl optionally substituted with one or more R7.