Patent ID: 11958861
Assignee: INCYTE CORPORATION
Field: Organic fine chemistry (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 42:
43. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein:
W is CH2;
Y is CH2;
Ring A is selected from cyclobutyl, cyclopentyl, cyclohexyl, dihydroindenyl, tetrahydro-2H-pyranyl, tetrahydrofuranyl, azetidinyl, piperidinyl, pyrrolidinyl, azepanyl, dihydropyridinyl, azabicyclo[3.2.1]octanyl, 2-azaspiro[3.3]heptanyl, and 7-azaspiro[3.5]nonanyl, wherein the cyclobutyl, cyclopentyl, tetrahydro-2H-pyranyl, tetrahydrofuranyl, azetidinyl, piperidinyl, pyrrolidinyl, azepanyl, dihydropyridinyl, azabicyclo[3.2.1]octanyl, 2-azaspiro[3.3]heptanyl, and 7-azaspiro[3.5]nonanyl of Ring A are each optionally substituted by 1 or 2 independently selected R6 substituents;
R2 is selected from H, ethyl, ethenyl, phenyl, indazolyl, thiazolyl, thieno[3,2-c]pyridinyl, 3,6-dihydro-2H-pyranyl, and indolyl, wherein the ethyl, ethenyl, phenyl, indazolyl, thiazolyl, thieno[3,2-c]pyridinyl, 3,6-dihydro-2H-pyranyl, and indolyl of R2 are each optionally substituted with 1, 2, 3, or 4 independently selected R2A substituents;
each R2A is independently selected from fluoro, methyl, CD3, trifluoromethyl, cyclopropyl, pyrazolyl, piperazinylmethyl, cyano, methoxy, and trifluoromethoxy, wherein the methyl, cyclopropyl, pyrazolyl, and piperazinylmethyl are each optionally substituted with 1 or 2 independently selected R2B substituents;
each R2B is independently selected from C1-6 alkyl and S(O)2Rb22, wherein the C1-6 alkyl of R2B are each optionally substituted with CN;
each Rb22 is independently selected from H or C1-6 alkyl;
R3 is selected from phenyl, cyclopropyl, cyclohexenyl, pyrazolyl, pyrrolyl, 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridinyl, 6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazinyl, 3,4-dihydro-2H-benzo[b][1,4]oxazinyl, 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazolyl, and pyrazolo[1,5-a]pyrimidinyl, wherein the phenyl, cyclopropyl, cyclohexenyl, pyrazolyl, pyrrolyl, 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridinyl, 6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazinyl, 3,4-dihydro-2H-benzo[b][1,4]oxazinyl, 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazolyl, and pyrazolo[1,5-a]pyrimidinyl of R3 are each optionally substituted with 1, 2, 3, or 4 independently selected R3A substituents;
each R3A is independently selected from methyl, trideuteromethyl, ethyl, isopropyl, isobutyl, difluoroethyl, trifluoroethyl, methoxy, cyclopropyl, cyclopentyl, piperidinyl, tetrahydrofuranyl, tetrahydropyranyl, cyclopropylmethyl, cyclopropylethyl, phenylmethyl, pyridylmethyl, piperidinylmethyl, morpholinylmethyl, morpholinylethyl, morpholinylcarbonyl, dimethylaminocarbonyl, and ethylsulfonyl, wherein the methyl, ethyl, isopropyl, isobutyl, cyclopropyl, cyclopentyl, piperidinyl, tetrahydrofuranyl, tetrahydropyranyl, cyclopropylmethyl, cyclopropylethyl, phenylmethyl, pyridylmethyl, piperidinylmethyl, morpholinylmethyl, and morpholinylethyl of R3A are each optionally substituted with 1, 2, 3, or 4 independently selected R3B substituents;
each R3B is independently selected from hydroxy, methoxy, methylsulfonyl, methylcarbonyl, and cyano;
R4 is selected from H and C1-3 alkyl;
R5 is H;
each R6 is independently selected from ethyl, tert-butyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, azetidinyl, tetrahydrothiopheneyl, pyrazolyl, piperidinyl, pyrimidinyl, cyclopropylmethyl, spiro[3.3]heptanylmethyl, phenylmethyl, triazolylisopropyl, azetidinylisopropyl, 2-azabicyclo[2.1.1]hexanyl, bicyclo[1.1.1]pentanyl, methylcarbonyl, tetrahydropyranylmethylcarbonyl, propylcarbonyl, dimethylaminocarbonyl, methoxycarbonyl, phenylaminocarbonyl, ethylsulfonyl, cyclobutylcarbonylamino, cyclopropylsulfonyl, and cyclopropylsulfonylamino, wherein the ethyl, tert-butyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, azetidinyl, tetrahydrothiopheneyl, pyrazolyl, piperidinyl, pyrimidinyl, cyclopropylmethyl, spiro[3.3]heptanylmethyl, phenylmethyl, triazolylisopropyl, azetidinylisopropyl, 2-azabicyclo[2.1.1]hexanyl, bicyclo[1.1.1]pentanyl, methylcarbonyl, tetrahydropyranylmethylcarbonyl, propylcarbonyl, dimethylaminocarbonyl, methoxycarbonyl, phenylaminocarbonyl, ethylsulfonyl, cyclobutylcarbonylamino, cyclopropylsulfonyl, and cyclopropylsulfonylamino of R6 are each optionally substituted with 1 or 2 independently selected R6A substituents; and
each R6A is independently selected from fluoro, oxo, methyl, CN, methoxy, tetrahydropyranyl, methylcarbonyl, aminocarbonyl, methylcarbonylamino, ethylaminocarbonyl, methoxycarbonyl, methoxycarbonylamino, ethylaminocarbonylamino, ethylsulfonyl, and phenylsulfonylamino, wherein each methyl of R6A is optionally substituted by CN or aminocarbonyl; and wherein each tetrahydropyranyl of R6A is optionally substituted by cyanomethyl.