Patent ID: 11945860
Assignee: ONCOHOST LTD.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A  G | IPC A  C  G

Claim 0:
1. A method of treating a solid cancer in a subject in need thereof, the method comprising:
a. measuring IL-1α, IL-1β or both in a biological sample obtained from said subject at a time of 20 hours or more after a session of treatment with radiotherapy, wherein said radiotherapy is external beam radiotherapy, to determine the level of circulating IL-1α, IL-1β or both in response to radiotherapy in said subject, wherein said biological sample is selected from blood plasma, whole blood, blood serum or peripheral blood mononuclear cells;
b. obtaining a reference level for said circulating IL-1α, IL-1β or both in said subject before said session of treatment with said radiotherapy;
c. establishing a fold-change in said circulating IL-1α, IL-1β or both from said reference level to said level in response to radiotherapy;
d. determining said subject has a non-favorable response to said treatment with said radiotherapy if said fold-change is an increase of at least 1.5-fold; and
e. treating said subject determined to have a non-favorable response with said radiotherapy in combination an anti-IL-1β neutralizing monoclonal antibody;
thereby treating a solid cancer in a subject in need thereof.