Patent ID: 11911515
Assignee: AMNEAL COMPLEX PRODUCTS RESEARCH LLC
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 17:
18. A gastroretentive dosage form comprising a core, and a permeable elastic membrane comprising at least one orifice and surrounding the core,
wherein the core comprises pyridostigmine or a pharmaceutically acceptable salt thereof, and a gas generating agent,
wherein the permeable elastic membrane comprises a copolymer based on ethyl acrylate, methyl methacrylate, and trimethylammonioethyl methacrylate chloride,
wherein the copolymer is present in an amount of from about 70 wt % to about 95 wt %, based on the total weight of the membrane, and
wherein the dosage form exhibits at least about 200% volume gain at 60 minutes, measured from its original volume, in about 200 ml of a dissolution medium comprising pH 4.5 acetate buffer and about 100 mM sodium chloride, measured using Rotating Bottle method at about 5 rpm and about 37° C.