Patent ID: 11944645
Assignee: INNOVATIVE CELLULAR THERAPEUTICS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A method of enhancing an anti-tumor effect of a lymphocyte, the method comprising:
introducing an exogenous polynucleotide encoding Caveolae Associated Protein 3 (CAVIN3) or Zinc finger bed-type containing 2 (ZBED2) into lymphocytes to obtain modified lymphocytes;
contacting the modified lymphocytes with tumor cells that the modified lymphocytes bind; and
allowing the modified lymphocytes to generate an anti-tumor effect, wherein the anti-tumor effect of the modified lymphocytes is enhanced as compared to lymphocytes that do not express an exogenous CAVIN3 and ZBED2.