Patent ID: 11925614
Assignee: BASF AS
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 0:
1. A method of reducing fibrosis in a subject in need thereof, comprising administering to the subject a pharmaceutically effective amount of a compound of formula (II):, wherein R1 is selected from a C10-C22 alkenyl having 3-6 double bonds;
R2 and R3 are the same or different and are selected from the group of a hydrogen atom, a hydroxy group, an alkyl group, a halogen atom, an alkoxy group, an acyloxy group, an acyl group, an alkenyl group, an alkynyl group, an aryl group, an alkylthio group, an alkoxycarbonyl group, a carboxy group, an alkylsulfinyl group, an alkylsulfonyl group, an amino group, and an alkylamino group; wherein R2 and R3 can be connected in order to form a cycloalkane like cyclopropane, cyclobutane, cyclopentane or cyclohexane;
X is a carboxylic acid or a derivative thereof; wherein the derivative is a carboxylate, a carboxylic ester, a glyceride, an anhydride, a carboxamide, a phospholipid, or a hydroxymethyl;
or a pharmaceutically acceptable salt, solvate, or solvate of such a salt, thereof;
wherein the subject has non-alcoholic steatohepatitis or alcoholic steatohepatitis; and
wherein the subject has hepatic fibrosis.