Patent ID: 11892453
Assignee: INBIOMOTION S.L.
Field: Pharmaceuticals (Chemistry)
Classification: CPC G  A  C | IPC A  C  G

Claim 8:
9. An in vitro method for designing a customized therapy for a subject having prostate cancer with bone metastasis which comprises
(i) quantifying the c-MAF gene expression level, copy number, or amplification in a bone metastatic tumor tissue sample of said subject;
(ii) comparing the expression level, copy number, or amplification obtained in step (i) with the expression level, copy number, or amplification of the c-MAF gene in a control sample, wherein an increase in the expression level, copy number, or amplification of the c-MAF gene in the tumor tissue sample is increased with respect to the expression level, copy number, or amplification of the c-MAF gene in the control sample, then said subject is susceptible to receive a therapy intended to prevent or inhibit bone degradation;
(iii) determining that the subject has an increase in the expression level, copy number or amplification of the c-MAF gene in the tumor tissue sample with respect to the expression level, copy number or amplification of the c-MAF gene in the control sample; and
(iv) administering a therapy intended to prevent or inhibit bone degradation.