Patent ID: 11893731
Assignee: VENTANA MEDICAL SYSTEMS, INC.
Field: Computer technology (Electrical engineering)
Classification: CPC G | IPC G

Claim 6:
7. A system comprising one or more processors and at least one memory, the at least one memory storing instructions which, when executed by the one or more processors, cause the system to perform one or more operations comprising:
accessing an image depicting a biological sample stained with a set of biomarkers;
accessing a reference color matrix, wherein the reference color matrix includes co-localization data for the set of biomarkers, wherein the co-localization data defines a plurality of groups of biomarkers within the set of biomarkers, each group of biomarkers of the plurality of groups of biomarkers including a subset of biomarkers of the set of biomarkers, wherein a first biomarker and a second biomarker of a subset of biomarkers of a first group of biomarkers of the plurality of groups of biomarkers represent a first common biological structure;
unmixing, based on the co-localization data of the reference color matrix, the image to generate a result that identifies, for one or more pixels of the image, a sparsity model that represents a first estimated fraction of contribution of the first biomarker and a second estimated fraction of contribution of the second biomarker; and
outputting the result.