Patent ID: 11903972
Assignee: SANBIO, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 0:
1. A method for suppressing the function of a TH1 helper T cell in a subject, the method comprising:
administering to the subject an effective amount of cells, wherein the cells are obtained by a method comprising:
(a) providing a culture of mesenchymal stem cells;
(b) contacting the cell culture of step (a) with a polynucleotide comprising sequences encoding a Notch intracellular domain (NICD) wherein said polynucleotide does not encode a full-length Notch protein;
(c) selecting cells that comprise the polynucleotide of step (b); and
(d) further culturing the selected cells of step (c) in the absence of selection for the polynucleotide;
wherein the function is selected from one or more of:
(i) activation of macrophages,
(ii) activation of cytotoxic T-cells,
(iii) activation of B cells,
(iv) secretion of interferon gamma (IFN-γ), and
(v) secretion of tumor necrosis factor alpha (TNF-α).