Patent ID: 11872279
Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 2:
3. A SARS-CoV-2 Spike (S) glycoprotein variant, wherein the S glycoprotein variant comprises an RBD having a mutation of at least one amino acid residue in a first and/or second aggregation-prone region relative to a wild-type RBD comprising the amino acid sequence of SEQ ID NO: 1, wherein the first aggregation-prone region comprises amino acid residues 122-126 of SEQ ID NO: 1, and the second aggregation-prone region comprises amino acid residues 158-162 of SEQ ID NO: 1, and wherein the mutation is a substitution with a different amino acid residue.