Patent ID: 11968993
Assignee: CARGILL, INCORPORATED
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 0:
1. A water-in-oil-in-water (W1/O/W2) emulsion comprising a lipid phase (O) and a water phase (W2), the lipid phase being distributed inside the water phase, wherein the lipid phase contains a plurality of water droplets (W1), wherein the water content inside the lipid phase is between 10 wt % and 80 wt % relative to the total weight of the lipid phase, wherein the water droplets are stabilized inside the lipid phase by a first emulsifier composition and a second emulsifier composition, the second emulsifier in range of from about 0.1 wt % to about 10 wt % of the emulsion, wherein the first emulsifier composition comprises an Acetone-insoluble (AI) component containing a Phosphatidyl Choline (PC), a Phosphatidyl Inositol (PI), a Phosphatidyl Ethanolamine (PE) and a Phosphatidic Acid (PA), wherein PC is in an amount by weight of at most 15.5% relative to the total weight of the first emulsifier composition and wherein the first emulsifier composition is characterized by a phospholipid weight ratio R of at most 65%, the ratio R being defined according to Formula 1:, R
          ⁡
          
            (
            
              in
              ⁢
              
                
              
              ⁢
              %
            
            )
          
        
        =
        
          100
          ×
          
            
              
                PC
                +
                PI
                +
                PE
                +
                PA
              
              AI
            
            .
          
        
      
    
    
      
        Formula
        ⁢
        
          
        
        ⁢
        1
      
    
  

wherein:
the water droplets (W1) have an average combined volume of at least 10% of the volume of the lipid droplet containing said water droplets;
PC+PI+PE+PA is the sum of the individual weights of the respective constituents of the AI component and AI is the total weight of the AI component; and
the second emulsifier comprises lecithin, a sorbitan ester, a sucrose ester, a protein, a polysaccharide, a carboxymethyl cellulose, or a mixture thereof.