Patent ID: 11891638
Assignee: NORTHWESTERN UNIVERSITY
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A method of delivering angiotensin converting enzyme 2 (ACE2) activity to the kidney, the method comprising administering to a subject, suffering from or at risk of developing kidney damage, a pharmaceutical composition comprising:
(a) a variant of ACE2 fused at its C-terminus via a linker amino acid sequence to a heterologous amino acid sequences, wherein the variant and linker amino acid sequence consist of the amino acids sequence of SEQ ID NO: 10 or SEQ ID NO:11 and the variant has ACE2 activity; or
(b) a variant of ACE2 comprising the amino acid sequence as set forth in SEQ ID NO:3 or SEQ ID NO: 4; wherein the variant has ACE2 activity, and a molecular weight ranging from 60 kDa to 71 kDa, wherein the variant allows for its delivery via glomerular filtration.