Patent ID: 11890300
Assignee: MILTENYI BIOTEC B.V. &CO.KG
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A T cell comprising:
a) a chimeric antigen receptor (CAR) comprising a first antigen binding domain, a first transmembrane domain and a first cytoplasmic signaling domain comprising at least one CD3ζ cytoplasmic signaling domain and at least one 4-1BB co-stimulatory signaling domain, wherein said first antigen binding domain binds to a tag of a tagged polypeptide, and wherein the polypeptide of said tagged polypeptide binds to an antigen expressed on the surface of a target cell to be killed; and
b) a chimeric costimulatory receptor (CCR) comprising a second antigen binding domain, a second transmembrane domain and a second cytoplasmic part comprising at least one CD28 co-stimulatory domain and/or at least one 4-1BB co-stimulatory domain or a combination thereof, wherein said CCR does not comprise CD3ζ, and wherein said second antigen binding domain binds to a further antigen, and wherein said further antigen is not expressed on the surface of said target cell.