Patent ID: 11897958
Assignee: BIO-TECHNE CORPORATION
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A method of treating a mammalian cancer comprising exposing a mammal comprising a mammalian cancer cell to a monoclonal antibody that binds to VSIG-4, wherein the monoclonal antibody comprises:
a heavy chain variable region comprising the three complementarity determining regions (CDRs) of the heavy chain of a monoclonal antibody produced by Ms x hVSIG4 528902.11 (ATCC Accession No. PTA-124187), and a light chain variable region comprising the three CDRs of the light chain of a monoclonal antibody produced by Ms x hVSIG4 528902.11 (ATCC Accession No. PTA-124187);
a heavy chain variable region comprising the three CDRs of the heavy chain of a monoclonal antibody produced by Ms x hVSIG4 528903.111 (ATCC Accession No. PTA-124188), and a light chain variable region comprising the three CDRs of the light chain of a monoclonal antibody produced by Ms x hVSIG4 528903.111 (ATCC Accession No. PTA-124188);
a heavy chain variable region comprising the three CDRs of the heavy chain of a monoclonal antibody produced by Ms x hVSIG4 528905.11 (ATCC Accession No. PTA-124189), and a light chain variable region comprising the three CDRs of the light chain of a monoclonal antibody produced by Ms x hVSIG4 528905.11 (ATCC Accession No. PTA-124189);
a heavy chain variable region comprising the three CDRs of the heavy chain of a monoclonal antibody produced by Ms x hVSIG4 528906.11 (ATCC Accession No. PTA-124178), and a light chain variable region comprising the three CDRs of the light chain of a monoclonal antibody produced by Ms x hVSIG4 528906.11 (ATCC Accession No. PTA-124178);
a heavy chain variable region comprising the three CDRs of the heavy chain of a monoclonal antibody produced by Ms x hVSIG4 528908.11 (ATCC Accession No. PTA-124179), and a light chain variable region comprising the three CDRs of the light chain of a monoclonal antibody produced by Ms x hVSIG4 528908.11 (ATCC Accession No. PTA-124179);
a heavy chain variable region comprising the three CDRs of the heavy chain of a monoclonal antibody produced by Ms x hVSIG4 528910.111 (ATCC Accession No. PTA-124180), and a light chain variable region comprising the three CDRs of the light chain of a monoclonal antibody produced by Ms x hVSIG4 528910.111 (ATCC Accession No. PTA-124180);
a heavy chain variable region comprising the three CDRs of the heavy chain of a monoclonal antibody produced by Ms x hVSIG4 528912.11 (ATCC Accession No. PTA-124181), and a light chain variable region comprising the three CDRs of the light chain of a monoclonal antibody produced by Ms x hVSIG4 528912.11 (ATCC Accession No. PTA-124181);
a heavy chain variable region comprising the three CDRs of the heavy chain of a monoclonal antibody produced by Ms x hVSIG4 528922.111 (ATCC Accession No. PTA-124182), and a light chain variable region comprising the three CDRs of the light chain of a monoclonal antibody produced by Ms x hVSIG4 528922.111 (ATCC Accession No. PTA-124182);
a heavy chain variable region comprising the three CDRs of the heavy chain of a monoclonal antibody produced by Ms x hVSIG4 528927.111 (ATCC Accession No. PTA-124183), and a light chain variable region comprising the three CDRs of the light chain of a monoclonal antibody produced by Ms x hVSIG4 528927.111 (ATCC Accession No. PTA-124183);
a heavy chain variable region comprising the three CDRs of the heavy chain of a monoclonal antibody produced by Rt x hVSIG4 489509.11 (ATCC Accession No. PTA-124184), and a light chain variable region comprising the three CDRs of the light chain of a monoclonal antibody produced by Rt x hVSIG4 489509.11 (ATCC Accession No. PTA-124184);
a heavy chain variable region comprising the three CDRs of the heavy chain of a monoclonal antibody produced by Rt x hVSIG4 489517.111 (ATCC Accession No. PTA-124185), and a light chain variable region comprising the three CDRs of the light chain of a monoclonal antibody produced by Rt x hVSIG4 489517.111 (ATCC Accession No. PTA-124185); or
a heavy chain variable region comprising the three CDRs of the heavy chain of a monoclonal antibody produced by Rt x hVSIG4 489518.11 (ATCC Accession No. PTA-124186), and a light chain variable region comprising the three CDRs of the light chain of a monoclonal antibody produced by Rt x hVSIG4 489518.11 (ATCC Accession No. PTA-124186).