Patent ID: 11872311
Assignee: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 0:
1. A metal-bisphosphonate nanoparticle comprising:
(a) a core comprising a multivalent metal ion-bisphosphonate complex, wherein the multivalent metal ion-bisphosphonate complex comprises a single type of multivalent metal ion and wherein the bisphosphonate is a compound with two phosphonate groups that are both attached to the same carbon atom, wherein said bisphosphonate has a structure of Formula (I):, wherein:
n and m are each independently an integer between 0 and 2;
each R is present or absent and when present is independently selected from the group consisting of H, alkyl, substituted alkyl, aralkyl, aryl, and substituted aryl;
R1 is selected from the group consisting of H, hydroxyl, halo, alkyl, substituted alkyl, amino, alkoxy, and alkylthio; and
R2 is selected from the group consisting of halo, alkyl, substituted alkyl, aralkyl, substituted aralkyl, alkoxy, alkylthio, aryloxy, arylthio and arylamino; or a salt thereof; and

(b) a coating layer surrounding at least a portion of an outer surface of the core, wherein the coating layer comprises a single lipid layer or a lipid bilayer.