Patent ID: 11926659
Assignee: PROTHENA BIOSCIENCES LIMITED
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C  G

Claim 0:
1. An isolated antibody specifically binding to human tau, comprising: a mature heavy chain variable region comprising CDR-H1 comprising SEQ ID NO:8, CDR-H2 comprising SEQ ID NO: 9 or SEQ ID NO: 149, and CDR-H3 comprising the amino acid sequence of LDF, wherein the heavy chain variable region is at least 90% identical to SEQ ID NO:18; and a mature light chain variable region comprising CDR-L1 comprising SEQ ID NO: 12, CDR-L2 comprising SEQ ID NO: 150, 151, 153, 156, 158, 159, 160, 163, 165, 166, 167, 168, 169, 170, 171, 172, 173 or 174, and CDR-L3 comprising SEQ ID NO:14, wherein the light chain variable region is at least 90% identical to SEQ ID NO: 122.