Patent ID: 11965885
Assignee: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
Field: Measurement (Instruments)
Classification: CPC G | IPC G

Claim 0:
1. A method of detecting the levels of antibodies in a sample of a subject having or suspected of having systemic lupus erythematosus (SLE), the method comprising:
(i) obtaining a serum, plasma, or blood sample from the subject;
(ii) exposing antibodies in the sample to at least four antigens, the antigens comprising single stranded DNA (ssDNA), U1 Small Nuclear Ribonucleoprotein (U1 snRNP), and Ro52, and at least one of: Smith antigen (Sm), Deoxyribonuclease I (DNAse I), Histone III-S, Histone H2A (H2a), Collagen III, and Serum amyloid A apolipoprotein (Apo-SAA); and
(iii) detecting in said sample the levels of antibodies reactive with each of the at least four antigens by quantifying the amount of antigen-antibody complex formed for each antigen, wherein the amount of antigen-antibody complex is indicative of the level of each respective antibody in said sample.