Patent ID: 11865186
Assignee: NORTHWESTERN UNIVERSITY
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 0:
1. A method of reversing cardiac electrical remodeling associated with atrial fibrillation (AF) in a subject suffering from cardiac electrical remodeling associated with atrial fibrillation, comprising co-administering to the subject by directly injecting into the atrium of a subject an effective amount of:
(a) an inhibitor of NADPH oxidase 2 (NOX2) gene expression selected from a short hairpin RNA (shRNA), a silencing RNA (siRNA), or an antisense RNA; and
(b) (i) a nucleic acid encoding a C-terminal Gαi inhibitory peptide, and/or
(ii) a nucleic acid encoding a C-terminal Gαo inhibitory peptide;, to the subject, wherein cardiac electrical remodeling associated with AF is reversed.