Patent ID: 11891601
Assignee: NATIONAL YANG MING CHIAO TUNG UNIVERSITY
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 4:
5. A method of inhibiting transcription of a gene containing expanded tri-nucleotide repeats in a cell, comprising:
administering to the cell a compound selected from an oligonucleotide that is complementary to a nucleic acid encoding SPT4 or SUPT4H, wherein the oligonucleotide is a siRNA, a shRNA, an antisense oligonucleotide, or a chemical reagent 6-chloropurine riboside; and
administering a compound that enhances R-loop formation, wherein the compound that enhances R-loop formation is selected from a topoisomerase inhibitor or an RNase H inhibitor,
wherein the gene contains a segment of DNA with CAG or CTG tri-nucleotide repeats that are prone to R-loop formation.