Patent ID: 11931331
Assignee: JOHNSON & JOHNSON SURGICAL VISION, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 9:
10. A method for treating a patient having decreased or low-level production/release/delivery/excretion of hyaluronic acid from and/or in the cornea comprising the step of topically administering to the eye the patient a composition comprising:
i) a safe and effective amount of a compound and/or extract having retinol-like properties and/or benefits for use in treating dry eye selected from one or more of:
botanical extracts, or sources of extracts, from plants of the genus Acronychia, Licaria, Calendula and/or Trigonella; bacterial extracts, or sources of extracts, of the genus Actinomyces; and compounds of Formula (I):, wherein—
the dotted lines represent simple or double bound; preferably one of the dotted line is a double bound;
R1 represent an H, a carbonated chain, linear, cyclic, or branched, saturated or unsaturated, comprising from 1 to 20 carbon atoms;
R2 represent a carbonated chain, linear, cyclic ringed, or branched, saturated or unsaturated, comprising from 1 to 20 carbon atoms; preferably a methyl (—CH3) or methylene (═CH2) moiety;
A represents a carbonated chain, linear, ringed, or branched, saturated or unsaturated, comprising from 1 to 20 carbon atoms; preferably from 1 to 10 carbon atoms; more preferably 6 carbon atoms; preferably an aromatic moiety, preferably a phenyl moiety; preferably 2-methyl -prop-1,3-diene.

ii) optionally, an ophthalmologically acceptable carrier.