Patent ID: 11867700
Assignee: THE TRUSTEES OF INDIANA UNIVERSITY
Field: Measurement (Instruments)
Classification: CPC G  H | IPC G  H

Claim 14:
15. A method of identifying components of lipoprotein particles in a density class, subtype of the density class or subpopulation of the subtype of the density class of intact lipoprotein particles present in a sample containing the intact lipoprotein particles, the method comprising:
a) producing lipoprotein ions from the intact lipoprotein particles contained in the sample,
b) measuring mass-to-charge ratios of the lipoprotein ions,
c) selecting a subset of the measured lipoprotein ions having mass-to-charge ratios within a selected range of mass-to-charge ratios,
d) dissociating the lipoprotein ions in the selected subset into fragment ions, and
e) simultaneously measuring a charge and a mass-to-charge ratio of the fragment ions;
f) determining masses of the fragment ions based on the measured charge and mass-to-charge ratio values thereof; and
g) identifying the components of the lipoprotein particles in the density class, subtype of the density class or subpopulation of the subtype of the density class of intact lipoprotein particles based on the determined masses of the fragment ions.