Patent ID: 11944424
Assignee: DUKE UNIVERSITY
Field: Measurement (Instruments)
Classification: CPC A  G | IPC A  G

Claim 31:
32. A method of non-invasively screening a subject for one or more cardiopulmonary conditions, comprising:
obtaining a series of 129Xe free induction decays (FIDs) of a gas exchange region of a lung or lungs of the subject during a breathing maneuver;
fitting real and imaginary components of the FIDs in a time domain with a curve fitting function modeled with one or more non-Lorentzian line shapes, wherein the curve fitting function models each of a 129Xe barrier resonance, a 129Xe gas-phase resonance and a 129Xe red blood cell (RBC) resonance, with the 129Xe barrier resonance modeled, at least in part, with the one or more non-Lorentzian line shapes;
electronically generating a plurality of 129Xe spectral parameters comprising RBC spectral parameters of RBC amplitude, RBC chemical shift (ppm), RBC full width at half maximum (FWHM) (ppm) and RBC phase (degrees) based on the fitting, wherein the plurality of 129Xe spectral parameters include static and dynamic 129Xe spectral parameters using plots over time of at least one of:
(i) barrier amplitude, barrier chemical shift (ppm), and one or more barrier FWHM (ppm) parameters; and
(ii) the RBC amplitude, the RBC chemical shift (ppm), the RBC FWHM (ppm), and the RBC phase (degrees),
wherein the static and dynamic 129Xe spectral parameters comprise RBC amplitude oscillations, RBC chemical shift oscillations, RBC FWHM oscillations and RBC phase oscillations;
obtaining 129Xe Magnetic Resonance Imaging (MRI) gas exchange images of the lung or lungs of the subject;
electronically calculating RBC transfer defects, ventilation defects and barrier defects from the 129Xe Magnetic Resonance Imaging (MM) gas exchange images of the lung or lungs of the subject and
electronically providing a database comprising a plurality of defined different disease patterns, wherein the plurality of defined disease patterns comprise:
pre-capillary pulmonary hypertension defined at least in part by a respective defined disease pattern comprising peak-to-peak amplitude of RBC amplitude oscillations that is 7.9% or less, and
post-capillary vascular disease defined at least in part by a respective defined disease pattern comprising peak-to-peak amplitude of RBC amplitude oscillations that is greater than 13.85%.