Patent ID: 11958861
Assignee: INCYTE CORPORATION
Field: Organic fine chemistry (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 40:
41. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein:
W is C(RW)2;
Y is C(RY)2;
each RW is independently H or C1-6 alkyl;
each R is independently H or C1-6 alkyl;
Ring A is C3-10 cycloalkyl or 4-10 membered heterocycloalkyl, wherein the C3-10 cycloalkyl and 4-10 membered heterocycloalkyl of Ring A are each optionally substituted with 1, 2, 3, or 4 independently selected R6 substituents;
R2 is selected from H, C1-6 alkyl, C2-6 alkenyl, C6-10 aryl, 5-10 membered heteroaryl, and 4-10 membered heterocycloalkyl, wherein the C1-6 alkyl, C2-6 alkenyl, C6-10 aryl, 5-10 membered heteroaryl, and 4-10 membered heterocycloalkyl of R2 are each optionally substituted with 1, 2, 3, or 4 independently selected R2A substituents;
each R2A is independently selected from halo, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, phenyl, C3-7 cycloalkyl, 5-6 membered heteroaryl, 4-6 membered heterocycloalkyl, (4-6 membered heterocycloalkyl)-C1-6 alkyl-, CN, and ORa21, wherein the C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, phenyl, C3-6 cycloalkyl, 5-6 membered heteroaryl, 4-6 membered heterocycloalkyl, and (4-6 membered heterocycloalkyl)-C1-6 alkyl- of R2A are each optionally substituted with 1, 2, 3, or 4 independently selected R2B substituents;
each Ra21 is independently selected from H, C1-6 alkyl, and C1-6 haloalkyl;
each R2B is independently selected from halo, oxo, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, and S(O)2Rb22, wherein the C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl of R2B are each optionally substituted with 1, 2, 3, or 4 independently selected R2C substituents;
each Rb22 is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, and C2-6 alkynyl;
each R2C is independently selected from halo, C1-6 alkyl, C1-6 haloalkyl, CN, and NO2;
R3 is selected from phenyl, C3-7 cycloalkyl, monocyclic 5-6 membered heteroaryl, bicyclic 8-10 membered heteroaryl, and bicyclic 8-10 membered heterocycloalkyl, wherein the phenyl, C3-7 cycloalkyl, monocyclic 5-6 membered heteroaryl, bicyclic 8-10 membered heteroaryl, and bicyclic 8-10 membered heterocycloalkyl of R3 are each optionally substituted with 1, 2, 3, or 4 independently selected R3A substituents;
each R3A is independently selected from oxo, C1-6 alkyl, C1-6 haloalkyl, C3-7 cycloalkyl, 4-6 membered heterocycloalkyl, phenyl-C1-6 alkyl-, C3-6 cycloalkyl-C1-6 alkyl-, (5-6 membered heteroaryl)-C1-6 alkyl-, (4-6 membered heterocycloalkyl)-C1-6 alkyl-, C(O)Rb31, C(O)NRc31Rd31, NRc31Rd31, and S(O)2Rb31, wherein the C1-6 alkyl, C3-7 cycloalkyl, 4-6 membered heterocycloalkyl, phenyl-C1-6 alkyl-, C3-6 cycloalkyl-C1-6 alkyl-, (5-6 membered heteroaryl)-C1-6 alkyl-, and (4-6 membered heterocycloalkyl)-C1-6 alkyl- of R3A are each optionally substituted with 1, 2, 3, or 4 independently selected R3B substituents;
each Rb31, Rc31, and Rd31 is independently selected from H, C1-6 alkyl, and 4-10 membered heterocycloalkyl;
each R3B is independently selected from CN, ORa32, C(O)Rb32, and S(O)2Rb32;
each Ra32 and Rb32 is independently selected from H and C1-6 alkyl;
R4 is selected from H and C1-3 alkyl;
R5 is H;
each R6 is independently selected from C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, phenyl, C3-7 cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C1-6 alkyl-, C3-7 cycloalkyl-C1-6 alkyl-, (5-6 membered heteroaryl)-C1-6 alkyl-, (4-7 membered heterocycloalkyl)-C1-6 alkyl-, C(O)Rb6, C(O)NRc6Rd6, C(O)ORa6, NRc6C(O)Rb6, NRc6S(O)2Rb6, and S(O)2Rb6, wherein the C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, phenyl, C3-7 cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C1-6 alkyl-, C3-7 cycloalkyl-C1-6 alkyl-, (5-6 membered heteroaryl)-C1-6 alkyl-, and (4-7 membered heterocycloalkyl)-C1-6 alkyl- of R6 are each optionally substituted with 1, 2, 3, or 4 independently selected R6A substituents;
each Ra6, Rb6, Rc6, and Rd6 is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, 4-7 membered heterocycloalkyl)-C1-6 alkyl-, wherein the C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl, and 4-10 membered heterocycloalkyl)-C1-6 alkyl- of Ra6, Rb6, Rc6, and Rd6 are each optionally substituted by 1, 2, 3, or 4 independently selected R6A substituents;
each R6A is independently selected from halo, oxo, C1-6 alkyl, 4-10 membered heterocycloalkyl, CN, ORa61, C(O)Rb61, C(O)NRc61Rd61, C(O)ORa61, NRc61C(O)Rb61, NRc61C(O)ORa61, NRc61C(O)NRc61Rd61, NRc61S(O)2Rb61, and S(O)2Rb61, wherein each C1-6 alkyl and 4-10 membered heterocycloalkyl of R6A are optionally substituted with 1, 2, 3, or 4 independently selected R6B substituents;
each Ra61, Rb61, Rc61, and Rd61 is independently selected from H, C1-6 alkyl, and phenyl, wherein the C1-6 alkyl and phenyl of Ra61, Rb61, Rc61, and Rd61 are each optionally substituted by 1 or 2 independently selected R6B substituents;
each R6B is independently selected from C1-6 alkyl, CN, and C(O)NRe62Rc62, wherein each C1-6 alkyl of R6B is optionally substituted by CN; and
each Rc62 and Rd62 is independently selected from H and C1-3 alkyl.