Patent ID: 11912779
Assignee: AVIDITY BIOSCIENCES, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A polynucleic acid molecule conjugate comprising:
an anti-transferrin receptor antibody or antigen binding fragment thereof conjugated to a polynucleic acid molecule that hybridizes to a target sequence of DUX4;
wherein the polynucleic acid molecule comprises a nucleic acid sequence selected from SEQ ID NOs: 72, 76, 126, or 131-136;
wherein the polynucleic acid molecule comprises 2′-F modified nucleotides only at positions 2, 6, 14, and 16; and
wherein the polynucleic acid molecule conjugate mediates RNA interference against the DUX4.