Patent ID: 11891368
Assignee: ALBIREO AB
Field: Organic fine chemistry (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A method for treating a disease or disorder in a subject, the method comprising administering to the subject a therapeutically effective amount of a compound of formula (I),, wherein M, R1, R2, R3, R4 and R5 are as indicated in Table 1 below:, TABLE 1

M
R1
R2
R3
R4
R5

CH2
CH2CH2CH2CH3
CH2CH2CH2CH3
F
SCH3
F

CH2
CH2CH2CH2CH3
CH2CH3
F
SCH3
H

CH2
CH2CH2CH2CH3
CH2CH3
F
SCH3
F

NH
CH2CH2CH2CH3
CH2CH3
F
SCH3
H

NH
CH2CH2CH2CH3
CH2CH3
F
SCH3
F

NCH3
CH2CH2CH2CH3
CH2CH3
F
SCH3
H

NCH3
CH2CH2CH2CH3
CH2CH3
F
SCH3
F

CH2
CH2CH2CH3
CH2CH3
H
SCH3
H

CH2
CH2CH2CH3
CH2CH3
H
SCH3
F

CH2
CH(CH3)2
CH2CH3
H
SCH3
H

CH2
CH(CH3)2
CH2CH3
H
SCH3
F

CH2
CH2CH2CH2CH3
CH2CH3
F
SCH2CH3
H

CH2
CH2CH2CH2CH3
CH2CH3
F
SCH2CH3
F

NH
CH2CH2CH2CH3
CH2CH3
H
SCH2CH3
H

NH
CH2CH2CH2CH3
CH2CH3
H
SCH2CH3
F

NH
CH2CH2CH2CH3
CH2CH3
F
SCH2CH3
H

NH
CH2CH2CH2CH3
CH2CH3
F
SCH2CH3
F

NCH3
CH2CH2CH2CH3
CH2CH3
H
SCH2CH3
H

NCH3
CH2CH2CH2CH3
CH2CH3
H
SCH2CH3
F

NCH3
CH2CH2CH2CH3
CH2CH3
F
SCH2CH3
H

NCH3
CH2CH2CH2CH3
CH2CH3
F
SCH2CH3
F

CH2
CH2CH2CH2CH3
CH2CH3
F
Cl
H

CH2
CH2CH2CH2CH3
CH2CH3
F
Cl
F

NH
CH2CH2CH2CH3
CH2CH3
H
Cl
H

NH
CH2CH2CH2CH3
CH2CH3
H
Cl
F

NH
CH2CH2CH2CH3
CH2CH3
F
Cl
H

NH
CH2CH2CH2CH3
CH2CH3
F
Cl
F

NCH3
CH2CH2CH2CH3
CH2CH3
H
Cl
H

NCH3
CH2CH2CH2CH3
CH2CH3
H
Cl
F

NCH3
CH2CH2CH2CH3
CH2CH3
F
Cl
H

NCH3
CH2CH2CH2CH3
CH2CH3
F
Cl
F

CH2
CH2CH2CH2CH3
CH2CH3
F
N(CH3)2
H

CH2
CH2CH2CH2CH3
CH2CH3
F
N(CH3)2
F

NH
CH2CH2CH2CH3
CH2CH3
H
N(CH3)2
H

NH
CH2CH2CH2CH3
CH2CH3
H
N(CH3)2
F

NH
CH2CH2CH2CH3
CH2CH3
F
N(CH3)2
H

NH
CH2CH2CH2CH3
CH2CH3
F
N(CH3)2
F

NCH3
CH2CH2CH2CH3
CH2CH3
H
N(CH3)2
H

NCH3
CH2CH2CH2CH3
CH2CH3
H
N(CH3)2
F

NCH3
CH2CH2CH2CH3
CH2CH3
F
N(CH3)2
H

NCH3
CH2CH2CH2CH3
CH2CH3
F
N(CH3)2
F

CH2
CH2CH2CH2CH3
CH2CH3
Cl
SCH3
F

NH
CH2CH2CH2CH3
CH2CH3
Cl
SCH3
F

NCH3
CH2CH2CH2CH3
CH2CH3
Cl
SCH3
F

CH2
CH2CH2CH2CH3
CH2CH3
Cl
Cl
F

NH
CH2CH2CH2CH3
CH2CH3
Cl
Cl
F

NCH3
CH2CH2CH2CH3
CH2CH3
Cl
Cl
F

CH2
CH2CH2CH2CH3
CH2CH3
Cl
N(CH3)2
F

NH
CH2CH2CH2CH3
CH2CH3
Cl
N(CH3)2
F

NCH3
CH2CH2CH2CH3
CH2CH3
Cl
N(CH3)2
F

or a pharmaceutically acceptable salt thereof, wherein the disease or disorder is selected from the group consisting of: a cardiovascular disease; a disorder of fatty acid metabolism; a glucose utilization disorder; a gastrointestinal disease or disorder; a liver disease or disorder; a hyperabsorption syndrome; hypervitaminosis and osteopetrosis; hypertension; glomerular hyperfiltration; or pruritus of renal failure.