Patent ID: 11897857
Assignee: MIDWESTERN UNIVERSITY
Field: Organic fine chemistry (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A method of treating one or more conditions associated with a disease selected from the group consisting of hypercholesterolemia, a viral disease, and blood coagulation disorders,
by administering one or more doses of
a pharmaceutical composition comprising one or more deuterated compounds of Formulas {I-A}, {I-B}, {I-C}, {I-D}, {I-E}, {I-F}, I-G}, or {I-H}:or one or more pharmaceutically-acceptable esters, metabolites, prodrugs, or solvates thereof and a pharmaceutically-acceptable carrier
in one or more amounts effective to treat one or more conditions associated said disease;
wherein at least one deuterated compound is represented by any one of the following Formulas:, or a salt, ester, metabolite, prodrug, or solvate thereof,
wherein Ar1 is a substituted or unsubstituted C6-C20 aryl or 5- to 20-membered heteroaryl;
wherein at least one of V1, V2, V3, V4, V5, or Z1, Z2, Z3, Z4, Z5, Z6, Z7, Z8, or Z9 is a deuterium atom (D) and any atom not designated as deuterium is present as hydrogen (H, or not shown) at its natural isotopic abundance;
wherein W is C(O), C(S), or S(O)2;
wherein Y is a single bond, O, CR50R51, or NR52 when W is CO and Y is a single bond, CR50R51 or NR52 when W is SO2; 
wherein R53 is selected from the group consisting of substituted or unsubstituted C1-C6 alkyl, substituted or unsubstituted C2-C6 alkenyl, substituted or unsubstituted C2-C6 alkynyl, substituted or unsubstituted C6-C20 aryl, substituted or unsubstituted C7-C26 arylalkyl, substituted or unsubstituted 5 to 20-membered heteroaryl, and substituted or unsubstituted 6-26 membered heteroarylalkyl; and
wherein Ar2, designated as an unsubstituted or substituted C6-C20 heteroaryl is selected from the group consisting of: phenyl; naphthyl; pyridyl; pyridine; pyridone; pyrimidine; pyradazine; pyrazine; purine; furan; thiophene; oxazole; thiazole; isoxazole; isothiazole; oxadiazole; thiadiazole; pyrrole; imidazole; triazole; tetrazole; and diazepine.