Patent ID: 11932699
Assignee: JCR PHARMACEUTICALS CO., LTD.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A stable aqueous pharmaceutical composition, comprising:
a fusion protein of an anti-human transferrin receptor antibody and human iduronate-2-sulfatase at a concentration of 5 mg/mL;
sodium chloride at a concentration of from 0.7 to 0.9 mg/mL;
sucrose at a concentration of from 70 to 80 mg/mL;
polyoxyethylene (160) polyoxypropylene (30) glycol at a concentration of from 0.3 to 0.8 mg/mL; and,
a phosphate buffer at a concentration of from 15 to 25 mM,
wherein the aqueous pharmaceutical composition has a pH of from 6.2 to 6.8, and
wherein the fusion protein comprises a light chain of the anti-human transferrin receptor antibody and a conjugate of a heavy chain of the anti-human transferrin receptor antibody with the human iduronate-2-sulfatase, and in the conjugate the human iduronate-2-sulfatase is linked at the C-terminal side of the heavy chain of the anti-human transferrin receptor antibody via a linker having the amino acid sequence of Gly-Ser, and wherein the conjugate has the amino acid sequence of SEQ ID NO:17 and the light chain has the amino acid sequence of SEQ ID NO:6.