Patent ID: 11904083
Assignee: FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 0:
1. A treatment system for reduction of carbon dioxide content in blood, of a patient, in an extracorporeal blood circuit, comprising:
a source of buffer solution for reducing carbon dioxide content in blood;
an apparatus for extracorporeal reduction of carbon dioxide content in blood, comprising a first delimited region for receiving extracorporeal blood and a second delimited region for receiving buffer solution from the source of buffer solution;
a buffer inlet for introducing the source of buffer solution into the second delimited region, the buffer inlet being in fluid communication with a buffer inlet port at the second delimited region;
a buffer outlet for extracting used buffer from the apparatus for the extracorporeal reduction of carbon dioxide content in blood, the buffer outlet being in fluid communication with a buffer outlet port at the second delimited region, wherein
the first delimited region and the second delimited region adjoin each other in a contact zone and are only separated by a membrane via which gas exchange occurs between the blood of the patient and the buffer solution,
the buffer solution is an aqueous solution in gas exchange contact with the blood of the patient in an extracorporeal circuit,
the buffer solution contains a buffer A and a buffer B,
buffer A consists of at least one buffer substance having a pK value of 7.9±0.2 at 37° C.,
buffer B consists of at least one buffer substance having a pK value of 6.9±0.2 at 37° C.,
the buffer solution has a post-titration pH value in the range of 8.25 to 8.35 at a carbon dioxide partial pressure of pCO2=0.2 mmHg±0.2, and
the source of buffer solution is in fluid communication with the buffer inlet port at the second delimited region, via a buffer inlet line;

a blood inlet for introducing a stream of the blood of the patient to be treated, into the treatment system, wherein the blood inlet is in fluid communication with a blood inlet port at the first delimited region, via a blood inlet line;
a blood outlet for extracting a treated bloodstream from the treatment system, wherein the blood outlet is in fluid communication with a blood outlet port at the first delimited region, via a blood outlet line;
a container for collecting used buffer solution, wherein the container for collecting the used buffer solution is in fluid communication with the buffer outlet port at the second delimited region, via a buffer outlet line;
an electronic monitoring and control unit;
a means for reducing the pressure in the buffer inlet line in fluid communication with the buffer inlet port at the second delimited region;
a first pressure sensor arranged between the buffer inlet port and the means for reducing the pressure in the buffer inlet line, the first pressure sensor being configured to record and send measured buffer inlet line pressure values to the electronic monitoring and control unit; and
a second pressure sensor arranged along the blood inlet line ahead of the blood inlet port, the second pressure sensor being configured to record and send measured blood inlet line pressure values to the electronic monitoring and control unit, wherein
the means for reducing the pressure in the fluid line comprises a throttling element, the means for reducing the pressure in the fluid line is arranged on the buffer inlet line, ahead of the buffer inlet port, so as to reduce the pressure in the buffer inlet line and in the buffer outlet line, and the electronic monitoring and control unit is configured to receive the measured buffer inlet line pressure values, to receive the measured blood inlet line pressure values, and to control a further course of treatment in order to effect a higher pressure in the blood inlet line than in the buffer inlet line and to effect a higher gas exchange rate and improved reduction of carbon dioxide content in the blood of the patient.