Patent ID: 11958861
Assignee: INCYTE CORPORATION
Field: Organic fine chemistry (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 50:
51. The compound of claim 1, which is selected from:
6-methyl-2-(4-((4-(methylsulfonyl)piperidin-1-yl)methyl)phenyl)-1-phenyl-1′-(pyrimidin-4-yl)-3,6-dihydro-7H-spiro[dipyrrolo[2,3-b:3′,2′-d]pyridine-8,4′-piperidin]-7-one;
(1R,3r,5S)-6′-methyl-2′-(4-((4-(methylsulfonyl)piperidin-1-yl)methyl)phenyl)-1′-phenyl-8-(pyrimidin-4-yl)-3′,6′-dihydro-7′H-8-azaspiro[bicyclo[3.2.1]octane-3, 8′-dipyrrolo[2,3-b:3′,2′-d]pyridin]-7′-one;
6-methyl-2-(1-methyl-1H-pyrazol-4-yl)-1-(2-methylthiazol-5-yl)-1′-(pyrimidin-4-yl)-3,6-dihydro-7H-spiro[dipyrrolo[2,3-b:3′,2′-d]pyridine-8,4′-piperidin]-7-one;
6-methyl-2-(1-methyl-1H-pyrazol-4-yl)-1′-(pyrimidin-4-yl)-1-vinyl-3,6-dihydro-7H-spiro[dipyrrolo[2,3-b:3′,2′-d]pyridine-8,4′-piperidin]-7-one;
1-ethyl-6-methyl-2-(1-methyl-1H-pyrazol-4-yl)-1′-(pyrimidin-4-yl)-3,6-dihydro-7H-spiro[dipyrrolo[2,3-b:3′,2′-d]pyridine-8,4′-piperidin]-7-one;
1-(3,6-dihydro-2H-pyran-4-yl)-6-methyl-2-(1-methyl-1H-pyrazol-4-yl)-1′-(pyrimidin-4-yl)-3,6-dihydro-7H-spiro[dipyrrolo[2,3-b:3′,2′-d]pyridine-8,4′-piperidin]-7-one;
N-(3-methoxyphenyl)-6-methyl-2-(4-((4-(methylsulfonyl)piperidin-1-yl)methyl)phenyl)-7-oxo-1-phenyl-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3′,2′-d]pyridine-8,4′-piperidine]-1′-carboxamide;
6′-methyl-2′-(1-methyl-1H-pyrazol-4-yl)-1′-(4-((4-(methylsulfonyl)piperazin-1-yl)methyl)phenyl)-3′,6′-dihydro-7′H-spiro[cyclopentane-1,8′-dipyrrolo[2,3-b:3′,2′-d]pyridin]-7′-one;
2-(1-(ethylsulfonyl)-3-(6-methyl-2-(1-methyl-1H-pyrazol-4-yl)-7-oxo-1-phenyl-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3′,2′-d]pyridine-8,4′-piperidin]-1′-yl)azetidin-3-yl)acetonitrile;
2-(1-acetyl-3-(6-methyl-2-(1-methyl-1H-pyrazol-4-yl)-7-oxo-1-phenyl-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3′,2′-d]pyridine-8,4′-piperidin]-1′-yl)azetidin-3-yl)acetonitrile;
3-(cyanomethyl)-N-ethyl-3-(6-methyl-2-(1-methyl-1H-pyrazol-4-yl)-7-oxo-1-phenyl-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3′,2′-d]pyridine-8,4′-piperidin]-1′-yl)azetidine-1-carboxamide;
2-(4-fluorophenyl)-2-(6-methyl-2-(1-methyl-1H-pyrazol-4-yl)-7-oxo-1-phenyl-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3′,2′-d]pyridine-8,4′-piperidin]-1′-yl)acetamide;
methyl (3-(cyanomethyl)-3-(6-methyl-2-(1-methyl-1H-pyrazol-4-yl)-7-oxo-1-phenyl-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3′,2′-d]pyridine-8,4′-piperidin]-1′-yl)cyclobutyl)carbamate;
1-(3-(cyanomethyl)-3-(6-methyl-2-(1-methyl-1H-pyrazol-4-yl)-7-oxo-1-phenyl-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3′,2′-d]pyridine-8,4′-piperidin]-1′-yl)cyclobutyl)-3-ethylurea;
N-(3-(cyanomethyl)-3-(6-methyl-2-(1-methyl-1H-pyrazol-4-yl)-7-oxo-1-phenyl-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3′,2′-d]pyridine-8,4′-piperidin]-1′-yl)cyclobutyl)benzenesulfonamide;
2-(1-(2-(1-(2,2-difluoroethyl)-1H-pyrazol-4-yl)-6-methyl-1-(1-methyl-1H-indazol-5-yl)-7-oxo-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3′,2′-d]pyridine-8,4′-piperidin]-1′-yl)cyclobutyl)acetonitrile;
2-(1-(6-methyl-1-(1-methyl-1H-indazol-5-yl)-2-(1-methyl-1H-pyrazol-4-yl)-7-oxo-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3′,2′-d]pyridine-8,4′-piperidin]-1′-yl)cyclobutyl)acetonitrile;
2-(1-(2-(1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl)-6-methyl-1-(1-methyl-1H-indazol-5-yl)-7-oxo-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3′,2′-d]pyridine-8,4′-piperidin]-1′-yl)cyclobutyl)acetonitrile;
2-(1-(6-methyl-1-(1-methyl-1H-indazol-5-yl)-7-oxo-2-(1-(2,2,2-trifluoroethyl)-1H-pyrazol-4-yl)-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3′,2′-d]pyridine-8,4′-piperidin]-1′-yl)cyclobutyl)acetonitrile;
2-(1-(6-methyl-1-(1-methyl-1H-indazol-5-yl)-2-(4-(morpholine-4-carbonyl)cyclohex-1-en-1-yl)-7-oxo-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3′,2′-d]pyridine-8,4′-piperidin]-1′-yl)cyclobutyl)acetonitrile;
2-(1-(2-(4-(ethylsulfonyl)phenyl)-6-methyl-1-(1-methyl-1H-indazol-5-yl)-7-oxo-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3′,2′-d]pyridine-8,4′-piperidin]-1′-yl)cyclobutyl)acetonitrile;
2-(1-(2-(1-(2-methoxyethyl)-1H-pyrazol-4-yl)-6-methyl-1-(1-methyl-1H-indazol-5-yl)-7-oxo-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3′,2′-d]pyridine-8,4′-piperidin]-1′-yl)cyclobutyl)acetonitrile;
2-(1-(2-(1-(1-hydroxy-2-methylpropan-2-yl)-1H-pyrazol-4-yl)-6-methyl-1-(1-methyl-1H-indazol-5-yl)-7-oxo-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3′,2′-d]pyridine-8,4′-piperidin]-1′-yl)cyclobutyl)acetonitrile;
2-(1-(6-methyl-1-(1-methyl-H-indazol-5-yl)-2-(1-(2-morpholinoethyl)-1H-pyrazol-4-yl)-7-oxo-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3′,2′-d]pyridine-8,4′-piperidin]-1′-yl)cyclobutyl)acetonitrile;
2-(1-(2-(1-(cyclopropylmethyl)-1H-pyrazol-4-yl)-6-methyl-1-(1-methyl-1H-indazol-5-yl)-7-oxo-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3′,2′-d]pyridine-8,4′-piperidin]-1′-yl)cyclobutyl)acetonitrile;
2-(1-(2-(3-cyclopropyl-1-methyl-1H-pyrazol-4-yl)-6-methyl-1-(1-methyl-1H-indazol-5-yl)-7-oxo-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3′,2′-d]pyridine-8,4′-piperidin]-1′-yl)cyclobutyl)acetonitrile;
2-(1-(2-(1-(1-acetylpiperidin-4-yl)-1H-pyrazol-4-yl)-6-methyl-1-(1-methyl-1H-indazol-5-yl)-7-oxo-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3′,2′-d]pyridine-8,4′-piperidin]-1′-yl)cyclobutyl)acetonitrile;
2-(1-(6-methyl-1-(1-methyl-H-indazol-5-yl)-2-(1-methyl-H-pyrrol-3-yl)-7-oxo-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3′,2′-d]pyridine-8,4′-piperidin]-1′-yl)cyclobutyl)acetonitrile;
2-(1-(6-methyl-1-(1-methyl-H-indazol-5-yl)-7-oxo-2-(4,5,6,7-tetrahydropyrazolo[1, 5-a]pyridin-3-yl)-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3′,2′-d]pyridine-8,4′-piperidin]-1′-yl)cyclobutyl)acetonitrile;
2-(1-(2-(1-(2-methoxy-2-methylpropyl)-1H-pyrazol-4-yl)-6-methyl-1-(1-methyl-1H-indazol-5-yl)-7-oxo-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3′,2′-d]pyridine-8,4′-piperidin]-1′-yl)cyclobutyl)acetonitrile;
2-(1-(6-methyl-1-(1-methyl-1H-indazol-5-yl)-7-oxo-2-(1-(tetrahydrofuran-3-yl)-1H-pyrazol-4-yl)-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3′,2′-d]pyridine-8,4′-piperidin]-1′-yl)cyclobutyl)acetonitrile;
2-(1-(2-(1-(2-methoxyethyl)-1H-pyrazol-4-yl)-6-methyl-1-(1-(methyl-d3)-1H-indol-5-yl)-7-oxo-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3′,2′-d]pyridine-8,4′-piperidin]-1′-yl)cyclobutyl)acetonitrile;
2-(1-(1-(3,5-difluoro-4-methoxyphenyl)-2-(1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl)-6-methyl-7-oxo-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3′,2′-d]pyridine-8,4′-piperidin]-1′-yl)cyclobutyl)acetonitrile;
2-(1-(2-(1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl)-6-methyl-7-oxo-1-(thieno[3,2-c]pyridin-2-yl)-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3′,2′-d]pyridine-8,4′-piperidin]-1′-yl)cyclobutyl)acetonitrile;
2-(1-(1-(4-cyclopropylphenyl)-2-(1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl)-6-methyl-7-oxo-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3′,2′-d]pyridine-8,4′-piperidin]-1′-yl)cyclobutyl)acetonitrile;
2-(1-(2-(1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl)-6-methyl-7-oxo-1-(4-(trifluoromethoxy)phenyl)-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3′,2′-d]pyridine-8,4′-piperidin]-1′-yl)cyclobutyl)acetonitrile;
4-(1′-(1-(cyanomethyl)cyclobutyl)-2-(1-(2,2-difluoroethyl)-1H-pyrazol-4-yl)-6-methyl-7-oxo-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3′,2′-d]pyridine-8,4′-piperidin]-1-yl)benzonitrile;
2-(1-(2-(1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl)-6-methyl-7-oxo-1-(4-(trifluoromethyl)phenyl)-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3′,2′-d]pyridine-8,4′-piperidin]-1′-yl)cyclobutyl)acetonitrile;
(R)-1-(ethylsulfonyl)-2′-(1-isopropyl-1H-pyrazol-4-yl)-6′-methyl-1′-(1-methyl-1H-indazol-5-yl)-3′,6′-dihydro-7′H-spiro[azepane-4,8′-dipyrrolo[2,3-b:3′,2′-d]pyridin]-7′-one;
(S)-1-(ethylsulfonyl)-2′-(1-isopropyl-1H-pyrazol-4-yl)-6′-methyl-1′-(1-methyl-1H-indazol-5-yl)-3′,6′-dihydro-7′H-spiro[azepane-4,8′-dipyrrolo[2,3-b:3′,2′-d]pyridin]-7′-one;
1-(ethylsulfonyl)-2″-(1-isopropyl-1H-pyrazol-4-yl)-6″-methyl-1″-(1-methyl-1H-indazol-5-yl)-3″,6″-dihydro-7″H-dispiro[azetidine-3,1′-cyclobutane-3′,8″-dipyrrolo[2,3-b:3′,2′-d]pyridin]-7″-one;
N-((1S,3R)-6′-methyl-1′-(1-methyl-1H-indazol-5-yl)-2′-(1-methyl-1H-pyrazol-4-yl)-7′-oxo-6′,7′-dihydro-3′H-spiro[cyclopentane-1,8′-dipyrrolo[2,3-b:3′,2′-d]pyridin]-3-yl)cyclopropanesulfonamide;
N-((1R,3S)-6′-methyl-1′-(1-methyl-1H-indazol-5-yl)-2′-(1-methyl-1H-pyrazol-4-yl)-7′-oxo-6′,7′-dihydro-3′H-spiro[cyclopentane-1,8′-dipyrrolo[2,3-b:3′,2′-d]pyridin]-3-yl)cyclopropanesulfonamide;
N-((1S,3S)-6′-methyl-1′-(1-(methyl-d3)-1H-indazol-5-yl)-2′-(1-methyl-1H-pyrazol-4-yl)-7′-oxo-6′,7′-dihydro-3′H-spiro[cyclopentane-1,8′-dipyrrolo[2,3-b:3′,2′-d]pyridin]-3-yl)cyclopropanesulfonamide;
N-((1R,3R)-6′-methyl-1′-(1-(methyl-d3)-1H-indazol-5-yl)-2′-(1-methyl-1H-pyrazol-4-yl)-7′-oxo-6′,7′-dihydro-3′H-spiro[cyclopentane-1,8′-dipyrrolo[2,3-b:3′,2′-d]pyridin]-3-yl)cyclopropanesulfonamide;
6-methyl-2-(4-((4-(methylsulfonyl)piperidin-1-yl)methyl)phenyl)-1′,3,3′,6-tetrahydro-7H-spiro[dipyrrolo[2,3-b:3′,2′-d]pyridine-8,2′-inden]-7-one;
methyl 6-methyl-2-(1-methyl-1H-pyrazol-4-yl)-1-(1-(methyl-d3)-1H-indazol-5-yl)-7-oxo-6,7-dihydro-3H-dispiro[dipyrrolo[2,3-b:3′,2′-d]pyridine-8,1′-cyclobutane-3′,4″-piperidine]-1″-carboxylate;
1″-butyryl-6-methyl-1-(1-methyl-1H-indazol-5-yl)-2-(1-methyl-1H-pyrazol-4-yl)-3,6-dihydro-7H-dispiro[dipyrrolo[2,3-b:3′,2′-d] pyridine-8,1′-cyclobutane-3′,4″-piperidin]-7-one;
N,N,6-trimethyl-1-(1-methyl-1H-indazol-5-yl)-2-(1-methyl-1H-pyrazol-4-yl)-7-oxo-6,7-dihydro-3H-dispiro[dipyrrolo[2,3-b:3′,2′-d]pyridine-8,1′-cyclobutane-3′,4″-piperidine]-1″-carboxamide;
methyl 6-methyl-1-(1-methyl-1H-indazol-5-yl)-2-(1-methyl-1H-pyrazol-4-yl)-7-oxo-6,7-dihydro-3H-dispiro [dipyrrolo[2,3-b:3′,2′-d]pyridine-8,1′-cyclobutane-3′,4″-piperidine]-1″-carboxylate;
1″-((2-methoxy ethyl)sulfonyl)-6-methyl-2-(1-methyl-1H-pyrazol-4-yl)-1-phenyl-3,6-dihydro-7H-dispiro[dipyrrolo[2,3-b:3′,2′-d] pyridine-8,1′-cyclobutane-3′,4″-piperidin]-7-one;
4-(1″-butyryl-6-methyl-1-(1-methyl-1H-indazol-5-yl)-7-oxo-6,7-dihydro-3H-dispiro [dipyrrolo[2,3-b:3′,2′-d]pyridine-8,1′-cyclobutane-3′,4″-piperidin]-2-yl)-N,N-dimethyl cyclohex-3-ene-1-carboxamide;
1″-butyryl-6-methyl-1-(1-methyl-1H-indazol-5-yl)-2-(1-methyl-1H-pyrrol-3-yl)-3,6-dihydro-7H-dispiro[dipyrrolo[2,3-b:3′,2′-d]pyridine-8,1′-cyclobutane-3′,4″-piperidin]-7-one;
(R)-2-(1-((6-methyl-1-(1-methyl-1H-indazol-5-yl)-2-(1-methyl-1H-pyrazol-4-yl)-7-oxo-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3′,2′-d]pyridine-8,3′-pyrrolidin]-1′-yl)methyl)cyclopropyl)acetonitrile;
(S)-2-(1-((6-methyl-1-(1-methyl-1H-indazol-5-yl)-2-(1-methyl-1H-pyrazol-4-yl)-7-oxo-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3′,2′-d]pyridine-8,3′-pyrrolidin]-1′-yl)methyl)cyclopropyl)acetonitrile;
2-(1-((6-methyl-1-(1-methyl-1H-indazol-5-yl)-7-oxo-2-(3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3′,2′-d]pyridine-8,3′-pyrrolidin]-1′-yl)methyl)cyclopropyl)acetonitrile;
2-(1-((6-methyl-1-(1-methyl-1H-indazol-5-yl)-7-oxo-2-(pyrazolo[1,5-a]pyrimidin-3-yl)-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3′,2′-d]pyridine-8,3′-pyrrolidin]-1′-yl)methyl)cyclopropyl)acetonitrile;
4-((4-(1′-((1-(cyanomethyl)cyclopropyl)methyl)-6-methyl-1-(1-methyl-1H-indazol-5-yl)-7-oxo-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3′,2′-d]pyridine-8,3′-pyrrolidin]-2-yl)-1H-pyrazol-1-yl)methyl)benzonitrile;
2-(2-((6-methyl-1-(1-methyl-1H-indazol-5-yl)-2-(1-methyl-1H-pyrazol-4-yl)-7-oxo-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3′,2′-d]pyridine-8,3′-pyrrolidin]-1′-yl)methyl)spiro[3.3]heptan-2-yl)acetonitrile;
2-(1-((6-methyl-1-(1-methyl-1H-indazol-5-yl)-2-(1-methyl-1H-pyrazol-4-yl)-7-oxo-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3′,2′-d]pyridine-8,3′-pyrrolidin]-1′-yl)sulfonyl)cyclopropyl)acetonitrile;
2-(1-((6-methoxy-1-(1-methyl-1H-indazol-5-yl)-2-(1-methyl-1H-pyrazol-4-yl)-7-oxo-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3′,2′-d]pyridine-8,3′-pyrrolidin]-1′-yl)methyl)cyclopropyl)acetonitrile;
2-(1-(6-methyl-1-(1-methyl-1H-indazol-5-yl)-2-(1-methyl-1H-pyrazol-4-yl)-7-oxo-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3′,2′-d]pyridine-8,4′-piperidin]-1′-yl)cyclopentyl)acetonitrile;
2-(1-(6-methyl-1-(1-methyl-1H-indazol-5-yl)-2-(1-methyl-1H-pyrazol-4-yl)-7-oxo-6,7-dihydro-1′H,3H-spiro[dipyrrolo[2,3-b:3′,2′-d]pyridine-8,4′-pyridin]-1′-yl)cyclopropyl)acetonitrile;
2-(4-methoxy-1-(6-methyl-1-(1-methyl-1H-indazol-5-yl)-2-(1-methyl-1H-pyrazol-4-yl)-7-oxo-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3′,2′-d]pyridine-8,4′-piperidin]-1′-yl)cyclohexyl)acetonitrile;
1′-(2-(1H-1,2,3-triazol-4-yl)propan-2-yl)-6-methyl-1-(1-methyl-1H-indazol-5-yl)-2-(1-methyl-1H-pyrazol-4-yl)-3,6-dihydro-7H-spiro[dipyrrolo[2,3-b:3′,2′-d]pyridine-8,4′-piperidin]-7-one;
1′-(2-(4H-1,2,4-triazol-3-yl)propan-2-yl)-6-methyl-1-(1-methyl-1H-indazol-5-yl)-2-(1-methyl-1H-pyrazol-4-yl)-3,6-dihydro-7H-spiro[dipyrrolo[2,3-b:3′,2′-d]pyridine-8,4′-piperidin]-7-one;
6-methyl-1′-(3-methyl-1,1-dioxidotetrahydrothiophen-3-yl)-1-(1-methyl-1H-indazol-5-yl)-2-(1-methyl-1H-pyrazol-4-yl)-3,6-dihydro-7H-spiro[dipyrrolo[2,3-b:3′,2′-d]pyridine-8,4′-piperidin]-7-one;
2-(1-(2-(5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)-6-methyl-1-(1-(methyl-d3)-1H-indazol-5-yl)-7-oxo-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3′,2′-d]pyridine-8,4′-piperidin]-1′-yl)cyclopentyl)acetonitrile;
(R)-4-methoxy-3-methyl-3-(6-methyl-2-(1-methyl-1H-pyrazol-4-yl)-1-(1-(methyl-d3)-1H-indazol-5-yl)-7-oxo-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3′,2′-d]pyridine-8,4′-piperidin]-1′-yl)butanenitrile;
(S)-4-methoxy-3-methyl-3-(6-methyl-2-(1-methyl-1H-pyrazol-4-yl)-1-(1-(methyl-d3)-1H-indazol-5-yl)-7-oxo-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3′,2′-d]pyridine-8,4′-piperidin]-1′-yl)butanenitrile;
methyl 4-(cyanomethyl)-4-(6-methyl-1-(1-methyl-1H-indazol-5-yl)-2-(1-methyl-1H-pyrazol-4-yl)-7-oxo-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3′,2′-d]pyridine-8,4′-piperidin]-1′-yl)piperidine-1-carboxylate;
N-(3-(6-methyl-1-(1-methyl-1H-indazol-5-yl)-2-(1-methyl-1H-pyrazol-4-yl)-7-oxo-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3′,2′-d]pyridine-8,4′-piperidin]-1′-yl)bicyclo[1.1.1]pentan-1-yl)acetamide;
methyl 4-(6-methyl-1-(1-methyl-1H-indazol-5-yl)-2-(1-methyl-1H-pyrazol-4-yl)-7-oxo-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3′,2′-d]pyridine-8,4′-piperidin]-1′-yl)-2-azabicyclo[2.1.1]hexane-2-carboxylate;
1′-(2-(azetidin-3-yl)propan-2-yl)-6-methyl-1-(1-methyl-1H-indazol-5-yl)-2-(1-methyl-1H-pyrazol-4-yl)-3,6-dihydro-7H-spiro[dipyrrolo[2,3-b:3′,2′-d]pyridine-8,4′-piperidin]-7-one;
1-(ethylsulfonyl)-6″-methyl-1″-(1-(methyl-d3)-1H-indazol-5-yl)-2″-(4-(morpholinomethyl)phenyl)-3″,6″-dihydro-7″H-dispiro[azetidine-3,1′-cyclobutane-3′,8″-dipyrrolo[2,3-b:3′,2′-d]pyridin]-7″-one;
1-(ethylsulfonyl)-6″-methyl-1″-(1-methyl-1H-indazol-5-yl)-2″-(1-methyl-1H-pyrazol-4-yl)-3″,6″-dihydro-7″H-dispiro[azetidine-3,1′-cyclobutane-3′,8″-dipyrrolo[2,3-b:3′,2′-d]pyridin]-7″-one;
2″-(1-(cyclopropylmethyl)-1H-pyrazol-4-yl)-1-(ethylsulfonyl)-6″-methyl-1″-(1-methyl-1H-indazol-5-yl)-3″,6″-dihydro-7″H-dispiro[azetidine-3,1′-cyclobutane-3′,8″-dipyrrolo[2,3-b:3′,2′-d]pyridin]-7″-one;
1-(ethylsulfonyl)-2″-(1-(2-methoxyethyl)-1H-pyrazol-4-yl)-6″-methyl-1″-(1-methyl-1H-indazol-5-yl)-3″,6″-dihydro-7″H-dispiro[azetidine-3,1′-cyclobutane-3′,8″-dipyrrolo[2,3-b:3′,2′-d]pyridin]-7″-one;
1-(ethylsulfonyl)-2″-(1-isopropyl-1H-pyrazol-4-yl)-6″-(methyl-d3)-1″-(1-methyl-1H-indazol-5-yl)-3″,6″-dihydro-7″H-dispiro[azetidine-3,1′-cyclobutane-3′,8″-dipyrrolo[2,3-b:3′,2′-d]pyridin]-7″-one;
2″-(1-cyclopentyl-1H-pyrazol-4-yl)-1-(ethylsulfonyl)-6″-methyl-1″-(1-methyl-1H-indazol-5-yl)-3″,6″-dihydro-7″H-dispiro[azetidine-3,1′-cyclobutane-3′,8″-dipyrrolo[2,3-b:3′,2′-d]pyridin]-7″-one;
1-(4-(1-(ethylsulfonyl)-6″-methyl-1″-(1-(methyl-d3)-1H-indazol-5-yl)-7″-oxo-6″,7″-dihydro-3″H-dispiro[azetidine-3,1′-cyclobutane-3′,8″-dipyrrolo[2,3-b:3′,2′-d]pyridin]-2″-yl)benzyl)piperidine-4-carbonitrile;
1-(ethylsulfonyl)-1″-(4-methoxyphenyl)-6″-(methyl-d3)-2″-(4-(morpholinomethyl)phenyl)-3″,6″-dihydro-7″H-dispiro[azetidine-3,1′-cyclobutane-3′,8″-dipyrrolo[2,3-b:3′,2′-d]pyridin]-7″-one;
2″-(1-(2,2-difluoroethyl)-1H-pyrazol-4-yl)-1-(ethylsulfonyl)-6″-methyl-1″-(1-methyl-1H-indazol-5-yl)-3″,6″-dihydro-7″H-dispiro[azetidine-3,1′-cyclobutane-3′,8″-dipyrrolo[2,3-b:3′,2′-d]pyridin]-7″-one;
2″-(5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)-1-(ethylsulfonyl)-6″-methyl-1″-(1-methyl-1H-indazol-5-yl)-3″,6″-dihydro-7″H-dispiro[azetidine-3,1′-cyclobutane-3′,8″-dipyrrolo[2,3-b:3′,2′-d]pyridin]-7″-one;
2″-(1-ethyl-1H-pyrazol-4-yl)-1-(ethylsulfonyl)-1″-(4-methoxyphenyl)-6″-(methyl-d3)-3″,6″-dihydro-7″H-dispiro[azetidine-3,1′-cyclobutane-3′,8″-dipyrrolo[2,3-b:3′,2′-d]pyridin]-7″-one;
1-(ethylsulfonyl)-2″-(1-(2-methoxy-2-methylpropyl)-1H-pyrazol-4-yl)-6″-methyl-1″-(1-(methyl-d3)-1H-indazol-5-yl)-3″,6″-dihydro-7″H-dispiro[azetidine-3,1′-cyclobutane-3′,8″-dipyrrolo[2,3-b:3′,2′-d]pyridin]-7″-one;
1-(ethylsulfonyl)-6″-methyl-1″-(1-methyl-1H-indazol-5-yl)-2″-(1-((tetrahydro-2H-pyran-4-yl)methyl)-1H-pyrazol-4-yl)-3″,6″-dihydro-7″H-dispiro[azetidine-3,1′-cyclobutane-3′,8″-dipyrrolo[2,3-b:3′,2′-d]pyridin]-7″-one;
2″-(6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazin-3-yl)-1-(ethylsulfonyl)-6″-methyl-1″-(1-(methyl-d3)-1H-indazol-5-yl)-3″,6″-dihydro-7″H-dispiro[azetidine-3,1′-cyclobutane-3′,8″-dipyrrolo[2,3-b:3′,2′-d]pyridin]-7″-one;
1-(ethylsulfonyl)-2″-(3-methoxy-1-methyl-1H-pyrazol-4-yl)-6″-methyl-1″-(1-(methyl-d3)-1H-indazol-5-yl)-3″,6″-dihydro-7″H-dispiro[azetidine-3,1′-cyclobutane-3′,8″-dipyrrolo[2,3-b:3′,2′-d]pyridin]-7″-one;
1-(2-amino-2-oxoethyl)-N-((1S,3S)-6′-methyl-2′-(1-methyl-1H-pyrazol-4-yl)-1′-(1-(methyl-d3)-1H-indazol-5-yl)-7′-oxo-6′,7′-dihydro-3′H-spiro[cyclopentane-1,8′-dipyrrolo[2,3-b:3′,2′-d]pyridin]-3-yl)cyclobutane-1-carboxamide;
1-(2-amino-2-oxoethyl)-N-((1R,3R)-6′-methyl-2′-(1-methyl-1H-pyrazol-4-yl)-1′-(1-(methyl-d3)-1H-indazol-5-yl)-7′-oxo-6′,7′-dihydro-3′H-spiro[cyclopentane-1,8′-dipyrrolo[2,3-b:3′,2′-d]pyridin]-3-yl)cyclobutane-1-carboxamide;
1″-butyryl-6-methyl-1-(1-methyl-1H-indazol-5-yl)-2-(1-(methyl-d3)-1H-pyrrol-3-yl)-3,6-dihydro-7H-dispiro[dipyrrolo[2,3-b:3′,2′-d]pyridine-8,1′-cyclobutane-3′,4″-piperidin]-7-one;
1″-butyryl-6-methyl-1-(1-(methyl-d3)-1H-indazol-5-yl)-2-(1-(methyl-d3)-1H-pyrrol-3-yl)-3,6-dihydro-7H-dispiro[dipyrrolo[2,3-b:3′,2′-d]pyridine-8,1′-cyclobutane-3′,4″-piperidin]-7-one;
2′-(1-isopropyl-1H-pyrazol-4-yl)-6′-(methyl-d3)-1′-(1-methyl-1H-indazol-5-yl)-1-((1-methylcyclopropyl)sulfonyl)-3′,6′-dihydro-7′H-spiro[azepane-4,8′-dipyrrolo[2,3-b:3′,2′-d]pyridin]-7′-one; and
2′-(1-(1-cyclopropylethyl)-1H-pyrazol-4-yl)-1-(ethylsulfonyl)-6′-(methyl-d3)-1′-(1-methyl-1H-indazol-5-yl)-3′,6′-dihydro-7′H-spiro[azepane-4,8′-dipyrrolo[2,3-b:3′,2′-d]pyridin]-7′-one;
or a pharmaceutically acceptable salt thereof.