Patent ID: 11890300
Assignee: MILTENYI BIOTEC B.V. &CO.KG
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 4:
5. The T cell according to claim 1, wherein the polypeptide of said tagged polypeptide is an antigen binding moiety (ABM), wherein the tag of said tagged polypeptide is a linker/label epitope (LLE) of a target cell binding molecule (TCBM), and wherein said CAR is an anti-linker/label epitope chimeric antigen receptor (anti-LLE CAR) comprising:
I) an extracellular linker/label epitope (LLE) binding domain;
II) a transmembrane domain; and
III) a cytoplasmic signaling domain comprising at least one CD3ζ cytoplasmic signaling domain and at least one 4-1BB co-stimulatory signaling domain,
wherein said extracellular LLE binding domain binds a target cell binding molecule (TCBM) comprising:
i) an antigen binding moiety (ABM), wherein said ABM binds specifically to said antigen expressed on the surface of said target cell;
ii) a label moiety (LaM), wherein said LaM is a naturally occurring molecule in a subject or a derivative thereof; and
iii) a linker moiety (LiM) conjugating said ABM and said LaM, thereby forming a linker/label epitope (LLE),
wherein said extracellular LLE binding domain binds said LLE with a higher preference than said naturally occurring molecule.