Patent ID: 11931548
Assignee: ROBERT EDWARD KEARNEY
Field: Medical technology (Instruments)
Classification: CPC A  G | IPC A  G

Claim 0:
1. A method for determining recommended multiple daily injection (MDI) therapy values for administering to a given subject, the method being executed by at least one processor, the at least one processor being operatively connected to an artificial pancreas system comprising a continuous glucose monitor (CGM) and an infusion pump, the method comprising:
receiving data values relating to a consumed meal by the given subject, an insulin basal dose administered to the given subject, and an insulin bolus dose administered to the given subject;
receiving an initial meal ratio parameter and an initial basal insulin dose used by the given subject;
predicting, using a computer model of the glucoregulatory system of the given subject based on the data values relating to the consumed meal by the given subject, the insulin basal dose, the insulin bolus dose, and the initial meal ratio parameter, a predicted glucose concentration parameter representative of predicted blood glucose concentration of the given subject after the consumed meal and administration of the insulin bolus dose and the insulin basal dose;
receiving, from the CGM of the artificial pancreas system, an actual glucose concentration parameter representative of an actual blood glucose concentration measurement of the given patient;
estimating, by a run-to-run (R2R) control algorithm using the computer model of the glucoregulatory system of the given subject based on the predicted glucose concentration parameter and the actual glucose concentration parameter, a set of optimal MDI therapy parameters; and
determining, based on the set of optimal MDI therapy parameters, a set of recommended MDI therapy parameters, the set of recommended MDI therapy parameters comprising an optimal meal ratio parameter to be consumed by the subject, and an optimal basal insulin dose to be administered to the given subject;
outputting the set of recommended MDI therapy parameters to the subject; and
transmitting, to the artificial pancreas system, a control command to cause the infusion pump to inject the optimal basal insulin dose to the subject.