Patent ID: 11858913
Assignee: ALIGOS THERAPEUTICS, INC.
Field: Organic fine chemistry (Chemistry)
Classification: CPC C  A | IPC C

Claim 14:
15. A compound selected from the group consisting of:
(R)-6-amino-2-(3,5-dichloro-4-((7-methyl-1-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyridazin-4-yl)oxy)phenyl)-1,2,4-triazine-3,5(2H,4H)-dione;
(S)-6-amino-2-(3,5-dichloro-4-((7-methyl-1-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyridazin-4-yl)oxy)phenyl)-1,2,4-triazine-3,5(2H,4H)-dione;
6-amino-2-(4-chloro-5-((7-methyl-1-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyridazin-4-yl)oxy)bicyclo[4.2.0]octa-1,3,5-trien-2-yl)-1,2,4-triazine-3,5(2H,4H)-dione;
6-amino-2-(3,5-dichloro-4-((7-methyl-1-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyridazin-4-yl)oxy)phenyl-2,6-d2)-1,2,4-triazine-3,5(2H,4H)-dione;
6-amino-2-(5-((7-cyclopropyl-1-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyridazin-4-yl)oxy)-4-methylbicyclo[4.2.0]octa-1,3,5-trien-2-yl)-1,2,4-triazine-3,5(2H,4H)-dione;
6-amino-2-(3,5-dichloro-4-((7-ethyl-1-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyridazin-4-yl)oxy)phenyl)-1,2,4-triazine-3,5(2H,4H)-dione;
6-amino-2-(3,5-dichloro-4-((7-cyclopropyl-1-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyridazin-4-yl)oxy)phenyl)-1,2,4-triazine-3,5(2H,4H)-dione;
6-amino-2-(3,5-dichloro-4-((7-(3,3-difluorocyclobutyl)-1-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyridazin-4-yl)oxy)phenyl)-1,2,4-triazine-3,5(2H,4H)-dione;
6-amino-2-(3,5-dichloro-4-((4′-oxo-3′,4′,6′,7′-tetrahydrospiro[cyclopentane-1,5′-cyclopenta[d]pyridazin]-1′-yl)oxy)phenyl)-1,2,4-triazine-3,5(2H,4H)-dione;
6-amino-2-(3,5-dichloro-4-((4-oxo-3,4,6,7-tetrahydrospiro[cyclopenta[d]pyridazine-5,1′-cyclopropan]-1-yl)oxy)phenyl)-1,2,4-triazine-3,5(2H,4H)-dione;
6-amino-2-(3,5-dichloro-4-((4′-oxo-3′,4′,6′,7′-tetrahydrospiro[cyclobutane-1,5′-cyclopenta[d]pyridazin]-1′-yl)oxy)phenyl)-1,2,4-triazine-3,5(2H,4H)-dione;
6-amino-2-(3,5-dichloro-4-((4-oxo-3,4,5,6,7,8-hexahydrophthalazin-1-yl)oxy)phenyl)-1,2,4-triazine-3,5(2H,4H)-dione;
6-amino-2-(3,5-dichloro-4-((5-methyl-4-oxo-3,4,5,6,7,8-hexahydrophthalazin-1-yl)oxy)phenyl)-1,2,4-triazine-3,5(2H,4H)-dione;
6-amino-2-(3,5-dichloro-4-((5-ethyl-4-oxo-3,4,5,6,7,8-hexahydrophthalazin-1-yl)oxy)phenyl)-1,2,4-triazine-3,5(2H,4H)-dione;
6-amino-2-(3,5-dichloro-4-((5-cyclopropyl-4-oxo-3,4,5,6,7,8-hexahydrophthalazin-1-yl)oxy)phenyl)-1,2,4-triazine-3,5(2H,4H)-dione;
6-amino-2-(3,5-dichloro-4-((5,5-dimethyl-4-oxo-3,4,5,6,7,8-hexahydrophthalazin-1-yl)oxy)phenyl)-1,2,4-triazine-3,5(2H,4H)-dione;
6-amino-2-(3,5-dichloro-4-((5,5-diethyl-4-oxo-3,4,5,6,7,8-hexahydrophthalazin-1-yl)oxy)phenyl)-1,2,4-triazine-3,5(2H,4H)-dione;
6-amino-2-(3,5-dichloro-4-((5-oxo-3,4-diazabicyclo[4.2.0]octa-1(6),2-dien-2-yl)oxy)phenyl)-1,2,4-triazine-3,5(2H,4H)-dione;
6-amino-2-(3,5-dichloro-4-((1-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyridazin-4-yl)oxy)phenyl)-1,2,4-triazine-3,5(2H,4H)-dione;
6-amino-2-(3,5-dichloro-4-((7,7-dimethyl-1-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyridazin-4-yl)oxy)phenyl)-1,2,4-triazine-3,5(2H,4H)-dione;
6-amino-2-(3,5-dichloro-4-((7,7-diethyl-1-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyridazin-4-yl)oxy)phenyl)-1,2,4-triazine-3,5(2H,4H)-dione;
6-amino-2-(3,5-dichloro-4-((4-oxo-3,4,4b,5,5a,6-hexahydrocyclopropa[3,4]cyclopenta[1,2-d]pyridazin-1-yl)oxy)phenyl)-1,2,4-triazine-3,5(2H,4H)-dione;
6-amino-2-(3,5-dichloro-4-((5-methyl-4-oxo-3,4,5,6,7,8-hexahydro-5,8-ethanophthalazin-1-yl)oxy)phenyl)-1,2,4-triazine-3,5(2H,4H)-dione;
6-amino-2-(3,5-dichloro-4-((9-methyl-1-oxo-2,5,6,7,8,9-hexahydro-1H-cyclohepta[d]pyridazin-4-yl)oxy)phenyl)-1,2,4-triazine-3,5(2H,4H)-dione;
6-amino-2-(3,5-dichloro-4-((7-methyl-1-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyridazin-4-yl)oxy)phenyl-2-d)-1,2,4-triazine-3,5(2H,4H)-dione;
6-amino-2-(3,5-dichloro-4-((7-cyclopropyl-1-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyridazin-4-yl)oxy)phenyl-2-d)-1,2,4-triazine-3,5(2H,4H)-dione;
6-amino-2-(3,5-dichloro-2-fluoro-4-((7-methyl-1-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyridazin-4-yl)oxy)phenyl)-1,2,4-triazine-3,5(2H,4H)-dione;
6-amino-2-(4-chloro-6-methyl-5-((7-methyl-1-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyridazin-4-yl)oxy)pyridin-2-yl)-1,2,4-triazine-3,5(2H,4H)-dione; and
6-amino-2-(3,5-dichloro-4-((4-oxo-3,4,5,6,7,8-hexahydro-5,8-methanophthalazin-1-yl)oxy)phenyl)-1,2,4-triazine-3,5(2H,4H)-dione;
or a stereoisomer or a tautomer thereof, or a pharmaceutically acceptable salt thereof.