Patent ID: 11911476
Assignee: PK MED
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  B  C | IPC A  B  C

Claim 0:
1. A process for preparing a drug delivery composition comprising at least a drug, comprising the steps of
a) preparing a masterbatch comprising a drug and a first polymer by
(i) heating the first polymer, wherein said first polymer has a melting temperature below 140° C.; and
(ii) introducing the drug during heating of the first polymer, with a drug content between 0.1% and 90%, based on the total weight of the masterbatch; and
b) introducing the masterbatch in a polymer-based matrix during production of the drug delivery composition,
wherein step a) is performed at a temperature at which the first polymer is in a partially or totally molten state, and step b) is performed at a temperature at which both the first polymer and at least a polymer of the polymer-based matrix are in a partially or totally molten state,
wherein the drug is selected from bone regenerative enzymes, hormones, cytokines, monoclonal antibodies and antigens;
and wherein the drug has a molecular mass above 14 kDa.