Patent ID: 11958831
Assignee: ARTIVILA (SHENZHEN) INNOVATION CENTER, LTD.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 2:
3. The compound or the pharmaceutically acceptable salt thereof according to claim 1, wherein the compound is selected from the group consisting of:
N-(1-(1-(1-acetylpiperidin-4-yl)azetidin-3-yl)-3-(difluoromethyl)-1H-pyrazol-4-yl)-6-(1-(2,2-difluoroethyl)-1H-pyrazol-4-yl)-2-picolinamide,
6-(1-(2,2-difluoroethyl)-1H-pyrazol-4-yl)-N-(3-(difluoromethyl)-1-(1-(1-(2-hydroxyacetyl)piperidin-4-yl)azetidin-3-yl)-1H-pyrazol-4-yl)-2-picolinamide,
N-(1-(1-(1-acetylpiperidin-4-yl)azetidin-3-yl)-3-(difluoromethyl)-1H-pyrazol-4-yl)-6-(1-(2,2,2-trifluoroethyl)-1H-pyrazol-4-yl)-2-picolinamide,
N-(3-(difluoromethyl)-1-(1-(1-(2-hydroxyacetyl)piperidin-4-yl)azetidin-3-yl)-1H-pyrazol-4-yl)-6-(1-(2,2,2-trifluoroethyl)-1H-pyrazol-4-yl)-2-picolinamide,
N-(1-(1-(1-acetylpiperidin-4-yl)azetidin-3-yl)-3-(difluoromethyl)-1H-pyrazol-4-yl)-6-(1-(difluoromethyl)-1H-pyrazol-4-yl)-2-picolinamide,
N-(1-(1-(1-acetylpiperidin-4-yl)azetidin-3-yl)-3-(difluoromethyl)-1H-pyrazol-4-yl)-6-(1-methyl-1H-pyrazol-4-yl)-2-picolinamide,
N-(1-(1-(1-acetylpiperidin-4-yl)azetidin-3-yl)-3-(difluoromethyl)-1H-pyrazol-4-yl)-6-(1-ethyl-1H-pyrazol-4-yl)-2-picolinamide,
N-(1-(1-(1-acetylpiperidin-4-yl)azetidin-3-yl)-3-(difluoromethyl)-1H-pyrazol-4-yl)-6-(1-isopropyl-1H-pyrazol-4-yl)-2-picolinamide,
N-(1-(1-(1-acetylpiperidin-4-yl)azetidin-3-yl)-3-(difluoromethyl)-1H-pyrazol-4-yl)-6-(1-(1-cyanocyclopropyl)-1H-pyrazol-4-yl)-2-picolinamide,
N-(1-(1-(1-acetylpiperidin-4-yl)azetidin-3-yl)-3-(difluoromethyl)-1H-pyrazol-4-yl)-6-(1-(1-cyanocyclobutyl)-1H-pyrazol-4-yl)-2-picolinamide,
N-(1-(1-(1-acetylpiperidin-4-yl)azetidin-3-yl)-3-(difluoromethyl)-1H-pyrazol-4-yl)-6-(1-(1-(aminomethyl)cyclobutyl)-1H-pyrazol-4-yl)-2-picolinamide,
N-(1-(1-(1-acetylpiperidin-4-yl)azetidin-3-yl)-3-(difluoromethyl)-1H-pyrazol-4-yl)-6-(1-(2-cyanopropan-2-yl)-1H-pyrazol-4-yl)-2-picolinamide,
N-(1-(1-(1-acetylpiperidin-4-yl)azetidin-3-yl)-3-(difluoromethyl)-1H-pyrazol-4-yl)-6-(1-(1-amino-2-methylpropan-2-yl)-1H-pyrazol-4-yl)-2-picolinamide,
N-(1-(1-(1-acetylpiperidin-4-yl)azetidin-3-yl)-3-(difluoromethyl)-1H-pyrazol-4-yl)-6-(1-(1-(hydroxymethyl)cyclobutyl)-1H-pyrazol-4-yl)-2-picolinamide,
N-(1-(1-(1-acetylpiperidin-4-yl)azetidin-3-yl)-3-(difluoromethyl)-1H-pyrazol-4-yl)-6-(1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl)-2-picolinamide,
N-(1-(1-(1-acetylpiperidin-4-yl)azetidin-3-yl)-3-(difluoromethyl)-1H-pyrazol-4-yl)-6-(1-(1-hydroxy-2-methylpropyl-2-yl)-1H-pyrazol-4-yl)-2-picolinamide,
6-(1-(1-amino-2-methylpropan-2-yl)-1H-pyrazol-4-yl)-N-(3-(difluoromethyl)-1-(1-(1-(dimethylcarbamoyl)piperidin-4-yl)azetidin-3-yl)-1H-pyrazol-4-yl)-2-picolinamide,
methyl 4-(3-(4-(6-(1-(1-amino-2-methylpropan-2-yl)-1H-pyrazol-4-yl)-2-picolinamide)-3-(difluoromethyl)-1H-pyrazol-1-yl)azetidin-1-yl)piperidine-1-carboxylate,
N-(1-(1-(1-acetylpiperidin-4-yl)azetidin-3-yl)-3-(difluoromethyl)-1H-pyrazol-4-yl)-6-(1H-pyrazol-4-yl)-2-picolinamide,
N-(3-(difluoromethyl)-1-(1-(1-(dimethylcarbamoyl)piperidin-4-yl)azetidin-3-yl)-1H-pyrazol-4-yl)-6-(1H-pyrazol-4-yl)-2-picolinamide,
methyl 4-(3-(4-(6-(1H-pyrazol-4-yl)-2-picolinamide)-3-(difluoromethyl)-1H-pyrazol-1-yl)azetidin-1-yl)piperidine-1-carboxylate,
N-(1-(1-(1-acryloylpiperidin-4-yl)azetidin-3-yl)-3-(difluoromethyl)-1H-pyrazol-4-yl)-6-(1H-pyrazol-4-yl)-2-picolinamide,
N-(1-(1-(1-acryloylpiperidin-4-yl)azetidin-3-yl)-3-(difluoromethyl)-1H-pyrazol-4-yl)-6-(1H-pyrazol-3-yl)-2-picolinamide,
N-(1-(1-(1-acetylpiperidin-4-yl)azetidin-3-yl)-3-(difluoromethyl)-1H-pyrazol-4-yl)-6-(1H-pyrazol-3-yl)-2-picolinamide,
methyl 4-(3-(4-(6-(1H-pyrazol-3-yl)-2-picolinamide)-3-(difluoromethyl)-1H-pyrazol-1-yl)azetidin-1-yl)piperidine-1-carboxylate,
N-(3-(difluoromethyl)-1-(1-(1-propionylpiperidin-4-yl)azetidin-3-yl)-1H-pyrazol-4-yl)-6-(1H-pyrazol-3-yl)-2-picolinamide,
N-(3-(difluoromethyl)-1-(1-(1-(2-hydroxyacetyl)piperidin-4-yl)azetidin-3-yl)-1H-pyrazol-4-yl)-6-(1H-pyrazol-3-yl)-2-picolinamide,
N-(3-(difluoromethyl)-1-(1-(1-(dimethylcarbamoyl)piperidin-4-yl)azetidin-3-yl)-1H-pyrazol-4-yl)-6-(1H-pyrazol-3-yl)-2-picolinamide,
N-(3-(difluoromethyl)-1-(1-(1-isobutyrylpiperidin-4-yl)azetidin-3-yl)-1H-pyrazol-4-yl)-6-(1H-pyrazol-3-yl)-2-picolinamide,
(S)—N-(3-(difluoromethyl)-1-(1-(1-(2-hydroxypropionyl)piperidin-4-yl)azetidin-3-yl)-1H-pyrazol-4-yl)-6-(1-(2,2,2-trifluoroethyl)-1H-pyrazol-4-yl)-2-picolinamide,
(R)—N-(3-(difluoromethyl)-1-(1-(1-(2-hydroxypropionyl)piperidin-4-yl)azetidin-3-yl)-1H-pyrazol-4-yl)-6-(1-(2,2,2-trifluoroethyl)-1H-pyrazol-4-yl)-2-picolinamide,
N-(3-(difluoromethyl)-1-(1-(1-(2-hydroxy-2-methylpropionyl)piperidin-4-yl)azetidin-3-yl)-1H-pyrazol-4-yl)-6-(1-(2,2,2-trifluoroethyl)-1H-pyrazol-4-yl)-2-picolinamide,
N-(3-(difluoromethyl)-1-(1-(1-(methylsulfonyl)piperidin-4-yl)azetidin-3-yl)-1H-pyrazol-4-yl)-6-(1-(2,2,2-trifluoroethyl)-1H-pyrazol-4-yl)-2-picolinamide,
(S)-6-(1-(2,2-difluoroethyl)-1H-pyrazol-4-yl)-N-(3-(difluoromethyl)-1-(1-(1-(2-hydroxypropionyl)piperidin-4-yl)azetidin-3-yl)-1H-pyrazol-4-yl)-2-picolinamide,
(R)-6-(1-(2,2-difluoroethyl)-1H-pyrazol-4-yl)-N-(3-(difluoromethyl)-1-(1-(1-(2-hydroxypropionyl)piperidin-4-yl)azetidin-3-yl)-1H-pyrazol-4-yl)-2-picolinamide,
6-(1-(2,2-difluoroethyl)-1H-pyrazol-4-yl)-N-(3-(difluoromethyl)-1-(1-(1-(2-hydroxy-2-methylpropionyl)piperidin-4-yl)azetidin-3-yl)-1H-pyrazol-4-yl)-2-picolinamide,
6-(1-(2,2-difluoroethyl)-1H-pyrazol-4-yl)-N-(3-(difluoromethyl)-1-(1-(1-(methylsulfonyl)piperidin-4-yl)azetidin-3-yl)-1H-pyrazol-4-yl)-2-picolinamide,
6-(1-(2,2-difluoroethyl)-1H-pyrazol-4-yl)-N-(3-(difluoromethyl)-1-(1-(1-(dimethylcarbamoyl)piperidin-4-yl)azetidin-3-yl)-1H-pyrazol-4-yl)-2-picolinamide,
(S)—N-(3-(difluoromethyl)-1-(1-(1-(2-hydroxypropionyl)piperidin-4-yl)azetidin-3-yl)-1H-pyrazol-4-yl)-6-(1H-pyrazol-3-yl)-2-picolinamide,
(R)—N-(3-(difluoromethyl)-1-(1-(1-(2-hydroxypropionyl)piperidin-4-yl)azetidin-3-yl)-1H-pyrazol-4-yl)-6-(1H-pyrazol-3-yl)-2-picolinamide,
N-(3-(difluoromethyl)-1-(1-(1-(2-hydroxy-2-methylpropionyl)piperidin-4-yl)azetidin-3-yl)-1H-pyrazol-4-yl)-6-(1H-pyrazol-3-yl)-2-picolinamide,
N-(3-(difluoromethyl)-1-(1-(1-(methylsulfonyl)piperidin-4-yl)azetidin-3-yl)-1H-pyrazol-4-yl)-6-(1H-pyrazol-3-yl)-2-picolinamide and
6-(1-(2-cyanopropan-2-yl)-1H-pyrazol-4-yl)-N-(3-(difluoromethyl)-1-(1-(1-(2-hydroxyacetyl)piperidin-4-yl)azetidin-3-yl)-1H-pyrazol-4-yl)-2-picolinamide.