Patent ID: 11903996
Assignee: nan
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C  Y | IPC A  C

Claim 1:
2. A human C3 protein (SEQ ID NO:1) or an active fragment thereof (SEQ ID NO:1 without amino acid residues 650 through 726) modified such that its affinity for complement factor H is lessened, thus increasing its half-life in vivo, wherein the modified C3 protein consists of one or more amino acid substitutions selected from the group consisting of: D733G; I734F; E738S; N739D; H897E; H898A; K1030T; T1033A; V1049T; Q1140Y; T1287R; H1291I; K1285P; and L1298G, wherein the position of the amino acid residue is based on the sequence of SEQ ID NO:1 numbering.