Patent ID: 11905291
Assignee: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
Field: nan (nan)
Classification: CPC nan | IPC C

Claim 11:
12. A bivalent compound selected from the group consisting of:, XF048- 133 

N1-((S)-1-((2S,4R)-4-hydroxy-2-((4-(4- methylthiazol-5- yl)benzyl)carbamoyl)pyrrolidin-1-yl)- 3,3-dimethyl-1-oxobutan-2-yl)-N11-(2- (4-((4′-(4-methylpiperazin-1-yl)-3′-(6- oxo-4-(trifluoromethyl)-1,6- dihydropyridine-3-carboxamido)- [1,1′-biphenyl]-3-yl)methyl)piperazin- 1-yl)ethyl)undecanediamide 

 

XF048- 140 

N-(3′-((4-(2-(8-((2-(2,6-dioxopiperidin- 3-yl)-1,3-dioxoisoindolin-4- yl)amino)octanamido)ethyl)piperazin- 1-yl)methyl)-4-(4-methylpiperazin-1- yl)-[1,1′-biphenyl]-3-yl)-6-oxo-4- (trifluoromethyl)-1,6- dihydropyridine-3-carboxamide 

 

XF048- 145 

N-(3′-((4-(1-((2-(2,6-dioxopiperidin-3- yl)-1,3-dioxoisoindolin-4-yl)amino)- 18-oxo-3,6,9,12,15-pentaoxa-19- azahenicosan-21-yl)piperazin-1- yl)methyl)-4-(4-methylpiperazin-1-yl)- [1,1′-biphenyl]-3-yl)-6-oxo-4- (trifluoromethyl)-1,6- dihydropyridine-3-carboxamide 

 

XF050- 169 

N1-((S)-1-((2S,4R)-4-hydroxy-2-((4-(4- methylthiazol-5- yl)benzyl)carbamoyl)pyrrolidin-1-yl)- 3,3-dimethyl-1-oxobutan-2-yl)-N11-(3- (4-((4′-(4-methylpiperazin-1-yl)-3′-(6- oxo-4-(trifluoromethyl)-1,6- dihydropyridine-3-carboxamido)- [1,1′-biphenyl]-3-yl)methyl)piperazin- 1-yl)propyl)undecanediamide 

 

XF056- 132 

N-(2′-fluoro-5′-((2-(((S)-1-((2S,4R)-4- hydroxy-2-((4-(4-methylthiazol-5- yl)benzyl)carbamoyl)pyrrolidin-1-yl)- 3,3-dimethyl-1-oxobutan-2-yl)amino)- 2-oxoethyl)carbamoyl)-4-((3R,5S)- 3,4,5-trimethylpiperazin-1-yl)-[1,1′- biphenyl]-3-yl)-6-oxo-4- (trifluoromethyl)-1,6- dihydropyridine-3-carboxamide 

 

XF067- 67 

N-(2′-fluoro-5′-((2-(((S)-1-((2S,4R)-4- hydroxy-2-(((S)-1-(4-(4-methylthiazol- 5- yl)phenyl)ethyl)carbamoyl)pyrrolidin- 1-yl)-3,3-dimethyl-1-oxobutan-2- yl)amino)-2-oxoethyl)carbamoyl)-4- ((3S,5R)-3,4,5-trimethylpiperazin-1- yl)-[1,1′-biphenyl]-3-yl)-6-oxo-4- (trifluoromethyl)-1,6- dihydropyridine-3-carboxamide