Patent ID: 11890339
Assignee: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 6:
7. The immunogen of claim 1, wherein the protomers of the NiV F ectodomain trimer comprise an amino acid sequence at least 90% identical to
residues 21-486 of any one of SEQ ID NOs: 5, 7-9, 11-18, 20-21, 23-24, and 26-32, or
residues 21-477 of any one of SEQ ID NOs: 19, 22, and 25; and, wherein the protomers comprise the one or more amino acid substitutions that stabilize the NiV F ectodomain trimer in the prefusion conformation.