Patent ID: 11958809
Assignee: CYTOKINETICS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 2:
3. The method of claim 2, wherein methyl 4-(2-fluoro-3-nitrobenzyl) piperazine-1-carboxylate hydrochloride, , is prepared by a process comprising:
Step (i) admixing 2-fluoro-3-nitrotolune (FN-Toluene), , with N-bromosuccinimide, benzoyl peroxide, and acetic acid to form a mixture of 1-(bromomethyl)-2-fluoro-3-nitrobenzene (FN-Bromide), , and 1-(dibromomethyl)-2-fluoro-3-nitrobenzene (Dibromide), Step (ii) contacting the mixture of FN-bromide and Dibromide with diethylphosphite and diisopropylethylamine in methanol to form a solution of FN-bromide;
Step (iii) admixing the solution of FN-bromide with diisopropylethylamine, and piperazine carboxylate, , in toluene to form a solution of Piperazine Nitro free base, , and
Step (iv) admixing the solution of Piperazine Nitro free base with IPA, water, and HCl to form methyl 4-(2-fluoro-3-nitrobenzyl)piperazine-1-carboxylate hydrochloride.