Patent ID: 11926619
Assignee: EISAI R&D MANAGEMENT CO., LTD
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A compound of Formula, or a pharmaceutically acceptable salt thereof,
wherein:
n is chosen from 0, 1, 2 or 3;
R1 is chosen from C1-C6 alkyl groups, C3-C8 cycloalkyl groups, —NR9R10,, groups,, groups,, groups,, groups,, groups,, groups,, groups, and, groups;
R9 is chosen from hydrogen, —NR11R12 groups, C1-C8 alkyl groups, —(C1-C6 alkyl)-CO2H groups, C3-C8 cycloalkyl groups, and heterocyclyl groups, wherein the —NR11R12 groups, C1-C8 alkyl groups, C3-C8 cycloalkyl groups, and heterocyclyl groups may be unsubstituted or substituted from 1-3 times with a group independently chosen from C1-C8 alkyl groups, —(C1-C8 alkyl)-CO2H groups, hydroxy, halogen groups, and C1-C8 alkoxy groups, and wherein the heterocyclyl group is a 3-, 4-, 5-, 6-, 7-, or 8-membered ring containing at least one heteroatom independently chosen from O, N, and S or a bicyclic heterocycle;
R10 is chosen from hydrogen and C1-C8 alkyl groups;
one of either R2 or R3 is chosen from hydrogen and C1-C8 alkyl groups, and the other is chosen from hydrogen, —OR10, —OC(O)R10, —OC(O)R10, and C1-C8 alkyl groups;
R4 is chosen from hydrogen and hydroxy;
R5 and R6 are each independently chosen from C1-C8 alkyl groups;
R7 and R8 are each independently chosen from hydrogen, hydroxy, C1-C8 alkoxy groups, and C1-C8 alkyl groups; and
Y is chosen from phenyl, thiophenyl, triazolyl, pyridinyl, pyrimidinyl, pyridazinyl, and pyrazinyl, wherein Y may be unsubstituted or substituted from 1-3 times with groups independently chosen from oxo groups, C1-C8 alkyl groups, C3-C5 cycloalkyl groups, hydroxy C1-C8 alkyl groups, C1-C8 alkoxy groups, methoxy C1-C8 alkyl groups, —NR11R12 groups,, wherein R11 and R12 are each independently chosen from hydrogen and C1-C6 alkyl groups;
wherein if:
Y is, R1 is a, group,
R2 is OR10 and R10 is hydrogen,
R3 is a C1-C6 alkyl group,
R4 is hydroxy,
R5 and R6 are each a C1-C6 alkyl group, and
one of R7 and R8 is hydrogen and the other is a C1-C6 alkyl group,
then R9 is not a 3-, 4-, 5-, 6-, 7-, or 8-membered ring containing one N; and

wherein if:
Y is, R1 is a, group,
R2 is OR10 and R10 is hydrogen,
R3 is a C1-C6 alkyl group,
R4 is hydroxy,
R5 and R6 are each a C1-C6 alkyl group, and
one of R7 and R8 is hydrogen and the other is a C1-C6 alkyl group,
then R9 is not a C1-C6 alkyl group or a C3-C8 cycloalkyl group.