Patent ID: 11918600
Assignee: SUZHOU RIBO LIFE SCIENCE CO., LTD.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 19:
20. The siRNA conjugate according to claim 16, wherein the ligand is a pharmaceutically acceptable conjugation group which comprises a pharmaceutically acceptable targeting group and a linker; and the siRNA, the linker and the targeting group are covalently linked in succession;
wherein the linker has a structure as shown by Formula (301):, wherein k is an integer of 1-3;
LA is an amide bond-comprising chain moiety that has a structure as shown by Formula (302), two terminals of which are respectively linked to the targeting group and the LC moiety each via an ether bond:, LB is an N-acylpyrrolidine-comprising chain moiety that has a structure as shown by Formula (303), which has a carbonyl group and is linked to the LC moiety via an amide bond at one end, and has an oxygen atom and is linked to the siRNA via a phosphoester bond at the other end thereof:, LC is a bivalent to tetravalent linking group based on hydroxymethyl aminomethane, dihydroxymethyl aminomethane or trihydroxymethyl aminomethane, LC being linked to each of the LA moieties through an ether bond via an oxygen atom, and being linked to the LB moiety through an amide bond via the nitrogen atom; or
wherein the linker has a structure as shown by Formula (306):, wherein,
l is an integer of 0-3;
* represents the site on the linker linked to the targeting group via ether bond; and
#represents the site on the linker linked to the siRNA via phosphoester bond.