Patent ID: 11884729
Assignee: APITBIO, INC
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C  G | IPC A  C

Claim 3:
4. The antibody or antigen-binding fragment thereof of claim 3, wherein the improved productivity is at least 55 mg/L, at least 56 mg/L, at least 57 mg/L, at least 58 mg/L, at least 59 mg/L, at least about 60 mg/L, at least about 61 mg/L, at least about 62 mg/L, at least about 63 mg/L, at least about 64 mg/L, at least about 65 mg/L, at least about 66 mg/L, at least about 67 mg/L, at least about 68 mg/L, at least about 69 mg/L, at least about 70 mg/L, at least about 71 mg/L, at least about 72 mg/L, at least about 73 mg/L, at least about 74 mg/L, at least about 75 mg/L, at least about 76 mg/L, at least about 77 mg/L, at least about 78 mg/L, at least about 79 mg/L, at least about mg/L, at least about 81 mg/L, at least about 82 mg/L, at least about 83 mg/L, at least about 84 mg/L, or at least about 85 mg/L;
wherein the improved Ku is less than 2.6×10−10 M, less than 2.5×−10−10 M, less than 2.0×10−10 M, less than 1.5×10−10 M, less than 1.0×10−10 M, less than 9×10−11 M, less than 8×10−11 M, less than 7×10−11 M, less than 6×10−11 M, less than 5×10−11 M, less than 4×10−11 M, less than 3×10−11 M, less than 2×10−11 M, less than 1×10−11 M, less than 9×10−12 M, less than 8×10−12 M, less than 7×10−12 M, less than 6×10−12 M, less than 5×10−12 M, less than 4×10−12 M, less than 3×10−12 M, less than 2×10−12 M, less than 1×10−12 M, less than 9×10−13 M, or less than 8×10−13 M;
wherein the improved affinity is less than 5×10−10 M, less than 4×10−10 M, less than 3×10−10 M, less than 2×10−10 M, less than 1.0×10−10 M, less than 9×10−11 M, less than 8×10−11 M, less than 7×10−11 M, less than 6×10−11 M, less than 5×10−11 M, less than 4×10−11 M, less than 3×10−11 M, less than 2×10−11 M, less than 1×10−11 M, less than 9×10−12 M, less than 8×10−12 M, less than 7×10−12 M, less than 6×10−12 M, less than 5×10−12 M, less than 4×10−12 M, less than 3×10−12 M, less than 2×10−12 M, less than 1×10−12 M, less than 9×10−13 M, or less than 8×10−13 M; and/or
wherein the improved PI Value is less than 9.6, less than 9.5, less than 9.4, less than 9.3, less than 9.2, less than 9.1, less than 9.0, less than 8.9, less than 8.8, less than 8.7, less than 8.6, less than 8.5, less than 8.4, less than 8.3, less than 8.2, less than 8.1, less than 8.0, less than 7.9, less than 7.8, less than 7.7, or less than 7.6.