Patent ID: 11946070
Assignee: SAMSUNG LIFE PUBLIC WELFARE FOUNDATION
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A method of reinforcing the efficacy of mesenchymal stem cells, comprising:
culturing stem cells for 72 hours in a medium comprising 10-200 μM ethionamide,
wherein the efficacy reinforcement is an improvement in expression of a paracrine factor in the stem cells, and
wherein the paracrine factor is one or more selected from the group consisting of a brain-derived neurotrophic issue (BDNF), a vascular endothelial cell growth factor (VEGF), insulin-like growth factor-1 (IGF-1), a hepatocyte growth factor (HGF), heme oxygenase-1 (HO-1), NAD(P)H:quinone oxidoreductase (NQO1), a glutamate-cysteine ligase catalytic subunit (GCLC) and a glutamate-cysteine ligase modifier subunit (GCLM).