Patent ID: 11913918
Assignee: PURIDIFY LTD.
Field: Measurement (Instruments)
Classification: CPC G | IPC G

Claim 0:
1. A chromatography system for at least one of tangential flow chromatography and lateral flow chromatography comprising:
an inlet;
a functionalized planar adsorbent chromatography medium downstream of the inlet, wherein the adsorbent chromatography medium is formed of one or more non-woven sheets, each comprising one or more polymer nanofibers, the adsorbent chromatography medium extending between a first edge of the adsorbent chromatography medium, facing the inlet and a second edge of the adsorbent chromatography medium, the second edge opposing the first edge;
an outlet downstream of and facing the second edge of the adsorbent chromatography medium; and
a flow guide downstream of the inlet and upstream of the adsorbent chromatography medium and configured to distribute a flow of a liquid from the inlet across a width along the first edge of the adsorbent chromatography medium,
wherein the flow guide comprises a pattern of channels providing flow paths from the inlet to different parts of the adsorbent chromatography medium along the first edge and across the width of the adsorbent chromatography medium,
wherein the pattern of channels is provided so as to reduce a difference in arrival time and/or flow velocity of liquid reaching the adsorbent chromatography medium from the inlet through the flow guide across the width of the adsorbent chromatography medium,
wherein the pattern of channels extends along and subdivides along a downstream direction parallel to a direction from the second edge toward the first edge of the chromatographic medium, and
wherein the pattern of channels is arranged such that longer flow paths have a smaller cross-sectional area than shorter flow paths.