Patent ID: 11938456
Assignee: DELPHI SCIENTIFIC, LLC
Field: Pharmaceuticals (Chemistry)
Classification: CPC B  A  C | IPC A  B

Claim 0:
1. A process for the preparation of layered particles comprising:
(a) forming a first liquid stream comprising:
(i) obtaining a first mixture of immiscible fluids that contains one or more core particles inside a first liquid carrier, wherein the first mixture is an emulsion;
(ii) optionally, homogenizing the first mixture; and
(iii) introducing one or more reactants into the first mixture;

(b) forming a second liquid stream comprising:
(i) introducing one or more reactants into a second liquid carrier;
(ii) mixing the one or more reactants in the second liquid carrier to form a second mixture; and
(iii) optionally, homogenizing the second mixture;

(c) continuously pumping the first liquid stream into a first port of a multi-port mixing device, wherein the first liquid stream is pumped into the mixing device at a fraction of the flow rate of the mixing device;
(d) continuously pumping the second liquid stream into a second port of the multi-port mixing device; and
(e) mixing the first liquid stream and the second liquid stream inside the mixing device for an effective period of time to form a layer on the one or more core particles, wherein the mixing is performed by the mixing device at an energy rate per kilogram of the mixture of liquid streams of from about 105 to about 1010 W/kg.