Patent ID: 11946028
Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
Field: Measurement (Instruments)
Classification: CPC C  A  G | IPC A  C  G

Claim 0:
1. A method for fabricating a multi-layer biomimetic organ model comprising:
(a) fabricating a body comprising
at least two channel slabs, and
at least one chamber slab;

(b) etching a microchannel into each of the at least two channel slabs;
(c) etching at least one chamber into the at least one chamber slab, the at least one chamber being tubular, exposed at a first surface of the at least one chamber slab and exposed at a second surface of the at least one chamber slab;
(d) inserting a cell embedded gel layer in the at least one chamber;
(e) inserting a first membrane between a first microchannel of a first channel slab and the at least one chamber, the first membrane having a first side facing the first microchannel and a second side facing the at least one chamber;
(f) inserting a second membrane between a second microchannel of a second channel slab and the at least one chamber, the second membrane having a first side facing the at least one chamber and a second side facing the second microchannel;
(g) adhering cells on a surface of at least the first side of the first membrane;
(h) coupling at least one device to one or more of the first microchannel and the second microchannel to deliver an agent; and
(i) delivering the agent.