Patent ID: 11939396
Assignee: GENENTECH, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 10:
11. The method of claim 7, wherein:
(i) the antibody is capable of inhibiting the enzymatic activity of human tryptase beta 1 at pH 6;
(ii) the antibody is capable of inhibiting tryptase-mediated stimulation of bronchial smooth muscle cell proliferation and/or collagen-based contraction;
(iii) the antibody is capable of inhibiting mast cell histamine release;
(iv) the antibody is capable of inhibiting IgE-triggered histamine release and/or tryptase-triggered histamine release;
(v) the antibody is capable of inhibiting tryptase activity in cynomolgus monkey bronchoalveolar lavage (BAL) or nasosorption samples;
(vi) the antibody is capable of dissociating tetrameric human tryptase beta 1;
(vii) the antibody is capable of dissociating tetrameric human tryptase beta 1 when in a monovalent format; and/or
(viii) the antibody is capable of dissociating tetrameric human tryptase beta 1 in the presence of heparin.