Patent ID: 11858913
Assignee: ALIGOS THERAPEUTICS, INC.
Field: Organic fine chemistry (Chemistry)
Classification: CPC C  A | IPC C

Claim 0:
1. A compound of Formula I:, , or a stereoisomer or a tautomer thereof, or a pharmaceutically acceptable salt thereof, wherein
R1 and R2 together with the carbon atoms to which they are attached form a C4-C7 non-aromatic monocyclic ring optionally substituted with 1 to 3 substituents independently selected from halogen, C1-C6 alkyl, and C3-C5 cycloalkyl optionally substituted with 1-3 halogens; or
R1 and R2 together with the carbon atoms to which they are attached form a C6 aromatic monocyclic ring; or
R1 and R2 together with the carbon atoms to which they are attached form a non-aromatic polycyclic ring optionally substituted with 1 to 3 substituents independently selected from halogen, C1-C6 alkyl, and C3-C5 cycloalkyl optionally substituted with 1-3 halogens;
R3 and R4 are each independently selected from halogen, —CN, optionally substituted C1-C3 alkyl, optionally substituted C1-C2 alkoxy, optionally substituted C2-C3 alkenyl, and cyclopropyl;
R5 is selected from:, R6 is H or C1-C3 alkyl;
R7 is H or C1-C3 alkyl;
R8 is selected from H, halogen, —CN, optionally substituted C1-C3 alkyl, and optionally substituted C1-C2 alkoxy; or
R3 and R8 together with the carbon atoms to which they are attached form a 4-, 5-, or 6-membered partially unsaturated carbocyclic ring; a 4-, 5-, or 6-membered partially unsaturated heterocyclic ring; a C6-C10 aryl ring; or a 5- or 6-membered heteroaryl ring;
Q is selected from N, CH, and CF; and
X is 0 or CH2;
wherein when R1 and R2 together with the carbon atoms to which they are attached form a C6 aromatic monocyclic ring, R5 is selected from:, and
wherein 0 to 10 hydrogen atoms that are attached to one or more carbon atoms are replaced with deuterium atom(s).