Patent ID: 11866511
Assignee: TIGATX, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 4:
5. The engineered antibody of claim 1, wherein the heavy chain constant region comprises:
(i) a N337T amino acid substitution at N337 according to Bur scheme, wherein said N337 corresponds to N207 of SEQ ID NO: 11, a I338L amino acid substitution at I338 according to Bur scheme, wherein said I338 corresponds to I208 of SEQ ID NO: 11, and a T339S amino acid substitution at T339 according to Bur scheme, wherein said T339 corresponds to T209 of SEQ ID NO: 11,
(ii) a N166G amino acid substitution at N166 according to Bur scheme, wherein said N166 corresponds to N49 of SEQ ID NO: 11,
(iii) a P221R amino acid substitution at P221 according to Bur scheme, wherein said P221 corresponds to P104 of SEQ ID NO: 11,
(iv) a C311S amino acid substitution at C311 according to Bur scheme, wherein said C311 corresponds to C181 of SEQ ID NO: 11,
(v) a deletion of amino acid C471 according to Bur scheme corresponding to C341 of SEQ ID NO: 11,
(vi) a deletion of amino acid Y472 according to Bur scheme corresponding to Y342 of SEQ ID NO: 11, or
(vii) a combination thereof.