Patent ID: 11918600
Assignee: SUZHOU RIBO LIFE SCIENCE CO., LTD.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 13:
14. The siRNA according to claim 13, wherein the siRNA is any one of the following siRNAs:
siHB1M1P

Sense strand: 5′-GmAmAmAmGmUmAfUfGfJmCmAmAmCmGmAmAmUmUm-3′   (SEQ ID NO:11),

Antisense strand: 5′-P1-AmAfUmUmCmGfUmUmGmAmCmAmUmAfCmUfUmUmCmUmUm-3′   (SEQ ID NO: 35);

siHB2M1P

Sense strand: 5′-GmAmAmAmGmUmAfUfGfUmCmAmAmCmGmAmAmUmUm-3′   (SEQ ID NO:11),

Antisense strand: 5′-P1-AmAfUmUmCmGfUmUmGmAmCmAmUmAfCmUfUmUmCmCmAm-3′   (SEQ ID NO: 35);

siHB3M1P

Sense strand: 5′-GmAmAmAmGmUmAfUfGfUmCmAmAmCmGmAmAmUmAm-3′   (SEQ ID NO:12),

Antisense strand: 5′-P1-UmAfUmUmCmGfUmUmGmAmCmAmUmAfCmUfUmUmCmUmUm-3′   (SEQ ID NO: 27);

siHB4M1P

Sense strand: 5′-GmAmAmAmGmUmAfUfGfJmCmAmAmCmGmAmAmUmAm-3′   (SEQ ID NO:12),

Antisense strand: 5′-P1-UmAfUmUmCmGfUmUmGmAmCmAmUmAfCmUfUmUmCmCmAm-3′   (SEQ ID NO:38);

siHB5M1P

Sense strand: 5′-UmGmGmAmAmAmGmUmAfUfGfUmCmAmAmCmGmAmAmUmAm-3′   (SEQ ID NO:51),

Antisense strand: 5′-P1-UmAfUmUmCmGfUmUmGmAmCmAmUmAfCmUfUmUmCmCmAmUmUm-3′   (SEQ ID NO:61);

siHB1M1SP

Sense strand: 5′-GmsAmsAmAmGmUmAfUfGfUmCmAmAmCmGmAmAmUmUm-3′   (SEQ ID NO:23),

Antisense strand: 5′-P1-AmsAfsUmUmCmGfUmUmGmAmCmAmUmAfCmUfUmUmCmsUmsUm-3′   (SEQ ID NO:43);

siHB2M1SP

Sense strand: 5′-GmsAmsAmAmGmUmAfUfGfUmCmAmAmCmGmAmAmUmUm-3′   (SEQ ID NO:23),

Antisense strand: 5′-P1-AmsAfsUmUmCmGfUmUmGmAmCmAmUmAfCmUfUmUmCmsCmsAm-3′   (SEQ ID NO:44);

siHB3M1SP

Sense strand: 5′-GmsAmsAmAmGmUmAfUfGfUmCmAmAmCmGmAmAmUmAm-3′   (SEQ ID NO:24),

Antisense strand: 5′-P1-UmsAfsUmUmCmGfUmUmGmAmCmAmUmAfCmUfUmUmCmsUmsUm-3′   (SEQ ID NO:45);

siHB4M1SP

Sense strand: 5′-GmsAmsAmAmGmUmAfUfGfUmCmAmAmCmGmAmAmUmAm-3′   (SEQ ID NO:24),

Antisense strand: 5′-P1-UmsAfsUmUmCmGfUmUmGmAmCmAmUmAfCmUfUmUmCmsCmsAm-3′   (SEQ ID NO:46);

siHB5M1SP

Sense strand: 5′-UmsGmsGmAmAmArnGmUmAfUfGfUmCmAmAmCmGmAmAmUmAm-3′   (SEQ ID NO:56),

Antisense strand: 5′-P1-UmsAfsUmUmCmGfUmUmGmAmCmAmUmAfCmUfUmUmCmsCmsAm-3′   (SEQ ID NO:64).