Patent ID: 11938348
Assignee: GENERAL ELECTRIC COMPANY
Field: Medical technology (Instruments)
Classification: CPC A | IPC A

Claim 0:
1. A modulation system comprising:
at least one energy application device, wherein the at least one energy application device is an ultrasound probe; and
a controller configured to:
focus the at least one energy application device on a first region of interest of a first tissue, the first tissue comprising a first plurality of axon terminals of respective neurons, one or more of the first plurality of axon terminals forming synapses between individual axon terminals and respective non-neuronal cells, wherein the first region of interest comprises a f first subset of the first plurality of axon terminals;
adjustably control the at least one energy application device to apply a first energy to the first region of interest to selectively modulate a first molecule of interest;
focus the at least one energy application device on a second region of interest, wherein the second region of interest comprises a second plurality of axon terminals;
adjustably control the at least one energy application device to apply a second energy to the second region of interest to selectively modulate the first molecule of interest or a second molecule of interest
cause the ultrasound probe to operate in an imaging mode configured to acquire reference image data of the first tissue and/or a second tissue before the application of the first energy or the second energy and post-treatment image data of the first tissue and/or the second tissue after the application of the first energy or the second energy; and
determine a displacement measurement of the first tissue and/or the second tissue based on a comparison of the reference image data and the post-treatment image data;
modify a modulation parameter of the first energy or the second energy based on the displacement measurement being below a threshold displacement associated with a concentration change of the first molecule.