Patent ID: 11872318
Assignee: THE JOHNS HOPKINS UNIVERSITY
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 0:
1. A pharmaceutical composition for topical administration to an eye, the pharmaceutical composition comprising:
(a) a plurality of coated nanoparticles, wherein each coated nanoparticles comprises:
(i) a particle core comprising one or more solid pharmaceutical agents or salts thereof, wherein the one or more solid pharmaceutical agents or salts thereof constitutes at least 80% of the particle core by weight; and
(ii) a coating comprising a surface-altering agent surrounding the particle core, wherein the surface-altering agent comprises a triblock copolymer comprising a hydrophilic block-hydrophobic block-hydrophilic block configuration, wherein the hydrophobic block has a molecular weight of at least 2 kDa, and the hydrophilic blocks constitute at least 15 wt % of the triblock copolymer; and

(b) one or more pharmaceutically acceptable excipients;
wherein the coated nanoparticles diffuse through mucus at a greater rate than a control nanoparticle.