Patent ID: 11911712
Assignee: FUJIFILM DIOSYNTH BIOTECHNOLOGIES UK LIMITED
Field: Chemical engineering (Chemistry)
Classification: CPC B  G | IPC B  G

Claim 16:
17. An apparatus for preparing an aqueous solution of a defined pH, wherein the apparatus comprises a metering device capable of feeding into a mixing device an acid, a base, and one or more additives, wherein the metering device operates under control of control apparatus for
a) calculating theoretical concentrations of acid, base and additive for each of a plurality of solutions having a theoretical pH corresponding to the defined pH, and each of the plurality of solutions having a different additive concentration within a range of different additive concentrations, wherein said calculating is carried out using the Henderson-Hasselbach equation in combination with the Debye Huckel theory;
b) for each solution, calculating a value for ΔpH, being the difference between the theoretical pH and a value for actual pH, for each of the plurality of solutions having a different additive concentration;
c) generating a mathematical model describing a relationship of ΔpH with additive concentration;
d) selecting the defined pH and additive concentration for the aqueous solution to be prepared;
e) using the mathematical model generated in step c) to calculate ΔpH for the defined pH and additive concentration;
f) calculating a ΔpH-corrected pH by summing the defined pH and ΔpH;
g) using the ΔpH-corrected pH to calculate concentrations of acid and base for the preparation of the aqueous solution including the one or more additives by using the Henderson-Hasselbach equation in combination with the Debye Huckel theory.