Patent ID: 11883820
Assignee: APPLIED CELLS INC.
Field: Measurement (Instruments)
Classification: CPC B  A  C  G | IPC A  B  C  G

Claim 15:
16. A device for separating biological entities from a sample fluid, the device comprising:
a substrate including:
a linear channel having an input end, an output end, a plurality of channel sections with different constant widths between said input and output ends, and one or more tapered transition sections with each tapered transition section interposed between two channel sections of said plurality of channel sections;
a first inlet connected to said linear channel at said input end for introducing a buffer fluid into said linear channel;
a second inlet for introducing said sample fluid into said linear channel;
a first pair of side channels connecting said second inlet to said linear channel at said input end;
a first outlet connected to said linear channel at said output end;
a second outlet; and
a second pair of side channels connecting said second outlet to said linear channel at said output end; and

a means for generating ultrasound in a form of a standing wave in said sample and buffer fluids in said plurality of channel sections to separate said biological entities by size,
wherein each of said plurality of channel sections has a constant width that is an integer multiple of one-half wavelength of said standing wave, and said plurality of channel sections become progressively narrower from said input end to said output end.