Patent ID: 11873489
Assignee: SILENCE THERAPEUTICS GMBH
Field: Biotechnology (Chemistry)
Classification: CPC C | IPC C

Claim 2:
3. The nucleic acid of claim 1, wherein the nucleic acid is conjugated to a ligand, wherein the first RNA strand is a compound of formula (XV):, wherein b is 0 or 1; and
the second RNA strand is a compound of formula (XVI):, wherein c and d are independently 0 or 1;
wherein:
Z1 and Z2 are the RNA portions of the first and second RNA strands respectively;
Y is O or S;
R1 is H or methyl;
n is 0, 1, 2 or 3; and
L is the same or different in formulae (XV) and (XVI) and is selected from the group consisting of:
—(CH2)q, wherein q=2-12;
—(CH2)r—C(O)—, wherein r=2-12;
—(CH2—CH2—O)s-CH2—C(O)—, wherein s=1-5;
—(CH2)t—CO—NH—(CH2)t—NH—C(O)—, wherein t is independently 1-5;
—(CH2)u—CO—NH—(CH2)u—C(O)—, wherein u is independently 1-5; and
—(CH2)v—NH—C(O)—, wherein v is 2-12; and
wherein the terminal C(O), if present, is attached to the NH group;
and wherein b+c+d is 2 or 3.