Patent ID: 11896676
Assignee: CASE WESTERN RESERVE UNIVERSITY
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 9:
10. A method of treating cancer in a subject identified as having cancer by administering to the subject a therapeutically effective amount of a pepino mosaic virus (PepMV) carrier comprising a PepMV particle modified to carry an anticancer agent,
wherein the PepMV carrier targets cancer tissue selected from the group consisting of ovarian cancer or triple negative breast cancer (TNBC) and has increased tumor homing to triple negative breast cancer (TNBC) tumors and to ovarian cancer tumors compared to a potato virus X (PVX) carrier,
wherein the PepMV carrier is administered via systemic or intraperitoneal (i.p.) administration, and
wherein the PepMV carrier has 1.5-fold increase in tumor homing in triple negative breast cancer (TNBC) tumors and 2-fold increase in tumor homing in ovarian cancer tumors compared to a potato virus X (PVX) carrier.