Patent ID: 11912674
Assignee: ILDONG PHARMACEUTICAL CO., LTD.
Field: Organic fine chemistry (Chemistry)
Classification: CPC C  A | IPC C

Claim 0:
1. A method for treating or ameliorating metabolic diseases, cholestatic liver diseases, or organ fibrosis, the method comprising:
administering to a subject a therapeutically effective amount of a pharmaceutical composition comprising (i) a compound represented by Formula I, a racemate, an enantiomer, or a diastereoisomer thereof, or a pharmaceutically acceptable salt of the compound, the racemate, the enantiomer, or the diastereoisomer and (ii) a carrier,, wherein:
R1 and R2 are each independently hydrogen, halo, or trifluoromethyl;
R6 and R7 are each independently hydrogen, halo, trifluoromethyl, or trifluoromethoxy;
Y is carbon or nitrogen; and
Z is, wherein:
n is 0, 1, or 2;
X1, X2, and X3 are each independently carbon or nitrogen;
Rc3 is hydrogen, halo, C1-6 alkyl, or C3-6 cycloalkyl;
W1, W2, and W3 are each independently oxygen, nitrogen, CHRw1, CRw1, NRw1, or CO, wherein Rw1 is hydrogen, halo, C1-6 alkyl, C3-6 cycloalkyl, halo C1-6 alkyl, C1-6 alkylamine, C1-6 alkyl alcohol,, (CH2)p heteroaryl, or (CH2)p aryl, wherein, p is 1, 2, or 3;
R5 is hydrogen, and
R3 and R4 are each independently hydrogen, halo, cyano, C1-6 alkyl, C3-6 cycloalkyl, halo C1-6 alkyl,, CONRa1Ra2, NRa1Ra2 CH2NRa1Ra2, CH2Rc3, CORa3, ORa3, NRa4CORa3, NRa4CO2Ra3, NHCONHRa3, NHSO2Ra3, or 3- or 8-membered heterocycles containing one or two oxygen or nitrogen atom(s) therein,
wherein:
m is 1 or 2;
Ra1 and Ra2 are each independently hydrogen, C1-6 alkyl, C3-6 cycloalkyl, halo C1-6 alkyl,, or 3- or 8-membered heterocycles containing one or two oxygen or nitrogen atom(s) therein;
Ra3 is hydrogen, C1-6 alkyl, C3-6 cycloalkyl, halo C1-6 alkyl,, or 3- or 8-membered heterocycles containing one or two oxygen or nitrogen atom(s) therein; and
Ra4 is hydrogen or C1-6 alkyl.