Patent ID: 11912763
Assignee: L & L BIOPHARMA CO., LTD.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 5:
6. The bispecific antibody as defined in claim 5, wherein the structure of the scFv is light chain variable region-linker-heavy chain variable region, and the N-terminal of the light chain variable region of the scFv or the C-terminal of the heavy chain variable region of the scFv is respectively linked to the C-terminal or N-terminal of the light chain or heavy chain of the immunoglobulin via a linker; or the structure of the scFv is heavy chain variable region-linker-light chain variable region, and the N-terminal of the heavy chain variable region of the scFv or the C-terminal of the light chain variable region of the scFv is respectively linked to the C-terminal or N-terminal of the light chain or heavy chain of the immunoglobulin via a linker; the linker is (G4S)3 (residues 449-463 of SEQ ID NO: 61), or, the bispecific antibody has two scFvs and the two scFvs are symmetrically linked to the light chain or heavy chain of the immunoglobulin; the scFv targeting CLDN18.2 or non-CLDN18.2 antigen.