Patent ID: 11903675
Assignee: VISEN MEDICAL, INC.
Field: Measurement (Instruments)
Classification: CPC A  G | IPC A  G

Claim 19:
20. An apparatus for reconstructing a tomographic representation of a probe within a target region of a diffuse object, the apparatus comprising:
one or more processors controlling operations of the apparatus; and
a memory that stores computer readable instructions that, when executed by the one or more processors, configure the apparatus to:
(a) establish a forward model of excitation light propagation from an excitation light source to the probe within the target region of the diffuse object and of emission light propagation from the probe to a detector using (i) data corresponding to detected fluorescent light from the probe, (ii) data corresponding to detected excitation light having been transmitted through the target region of the diffuse object or having been reflected from the target region of the diffuse object, and (iii) data corresponding to detected bioluminescent light emitted from a bioluminescent reporter, wherein at least some of the bioluminescent reporter is substantially co-located with at least some of the fluorescent light from the probe in the target region of the diffuse object, and wherein the forward model is established as a weight matrix; and
(b) invert the weight matrix to obtain the tomographic representation of the probe within the target region of the diffuse object.