Patent ID: 11857609
Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 0:
1. A method for treating retinal vein occlusion (RVO) in a patient in need thereof, wherein the method comprises administering to an eye having a retina of the patient an amount of an eye drop comprising a conjugate comprising an X-linked inhibitor of apoptosis (XIAP)-baculoviral IAP repeat 3 (BIR3) domain (XBIR3) and a cell-penetrating peptide,
wherein the XBIR3 comprises the sequence MGSSHHHHHHSSGLVPRGSHMSTNTCLPRNPSMADYEARIFTFGTWIYSVNK EQLARAGFYTDWALGEGDKVKCFHCGGGLRPSEDPWEQHARWYPGCRYLL EQRGQEYINNIHLTHS (SEQ ID NO: 11) MGSSHHHHHHSSGLVPRGSHMSTNTLPRNPSMADYEARIFTFGTWIYSVNKE QLARAGFYTDWALGEGDKVKCFHCGGGLRPSEDPWEQHARWYPGCRYLLE QRGQEYINNIHLTHS (SEQ ID NO: 12),
and wherein the amount of eye drop is effective to deliver the conjugate to the retina and treat the RVO.