Patent ID: 11859242
Assignee: CARNEGIE MELLON UNIVERSITY
Field: Measurement (Instruments)
Classification: CPC C  G | IPC C  G

Claim 4:
5. The genetic recognition reagent of claim 1, having the structure:, where,
each R is independently, a nucleobase of the plurality of nucleobases;
n is 1, 2, 3, 4, 5, or 6;
one instance of L is the linker to the first end of the nucleic acid analog backbone, and another instance of L is the linker to the second end of the nucleic acid analog backbone, wherein the linker to the first end of the nucleic acid analog backbone and the linker to the second end of the nucleic acid analog backbone each independently comprises one or more guanidine-containing groups, one or more amino acid side chains, or one or more contiguous amino acid residues;
each R3 is, independently, two- to five-ring fused polycyclic aromatic moieties,
R1 and R2 are each attached to a gamma carbon, and are, independently:
H, a guanidine-containing group, methyl, ethyl, an amino acid side chain, linear or branched ([C3-C8)alkyl, (C2-C8)alkenyl, (C2-C8)alkynyl, (C1-C8)hydroxyalkyl, (C3-C8)aryl, (C3-C8)cycloalkyl, (C3-C8)aryl(C1-C6)alkylene, or (C3-C8)cycloalkyl(C1-C6)alkylene; or
a guanidine-containing group, methyl, ethyl, an amino acid side chain, linear or branched (C3-C8)alkyl, (C2-C8)alkenyl, (C2-C8)alkynyl, (C1-C8)hydroxyalkyl, (C3-C8)aryl, (C3-C8)cycloalkyl, (C3-C8)aryl(C1-C6)alkylene, or (C3-C8)cycloalkyl(C1-C6)alkylene, wherein the guanidine-containing group, methyl, ethyl, an amino acid side chain, linear or branched (C3-C8)alkyl, (C2-C8)alkenyl, (C2-C8)alkynyl, (C1-C8)hydroxyalkyl, (C3-C8)aryl, (C3-C8)cycloalkyl, (C3-C8)aryl(C1-C6)alkylene, or (C3-C8)cycloalkyl(C1-C6)alkylene is substituted with an ethylene glycol unit comprising from 1 to 50 ethylene glycol moieties, —(OCH2—CH2)qOP1, —(OCH2—CH2)q—NHP1, —(SCH2—CH2)q—SP1, —(OCH2—CH2)r—OH, —(OCH2—CH2)r—NH2, —(OCH2—CH2)r—NHC(NH)NH2, or —(OCH2—CH2)r—S—S[CH2CH2]sNHC(NH)NH2, where P1 is H, (C1-C8)alkyl, (C2-C8)alkenyl, (C2-C8)alkynyl, (C3-C8)aryl, (C3-C8)cycloalkyl, (C3-C8)aryl(C1-C6)alkylene or (C3-C8)cycloalkyl(C1-C6)alkylene; q is an integer from 0 to 50; r is an integer from 1 to 50, and s is an integer from 1 to 50,

or a pharmaceutically-acceptable salt thereof.