Patent ID: 11912999
Assignee: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 12:
13. The aptamer-NHCM conjugate of claim 11, wherein each of the NHCMs, independently, is selected from the group consisting of:, each R group is independently H, C1-C18 alkyl, C2-C18 alkenyl, C2-C18 alkynyl, C6-C14 aryl, C7-C18 arylalkyl, C8-C18 arylalkenyl, C8-C18 arylalkynyl, C1-C18 alkoxy, C6-C14 aryloxy, C7-C18 arylalkyloxy, C2-C18 alkenyloxy, C2-C18 alkynyloxy, C8-C18 arylalkenyloxy, C8-C30 arylalkynyloxy, C2-C30 alkylester, C7-C15 arylester, C8-C30 alkylarylester, C3-C18 alkenylester, C3-C18 alkynylester, C3-C1 di- or poly-ether, C3-C18 di- or poly-etherester, C3-C18 di- or poly-ester, C3-C18 di- or poly-amine, or C4-C18 di- or poly-ene, and is optionally substituted or multiply substituted with any of Cl, Br, I, F, OH, R′2N, R′SO2, R′SO, R′S, R′3Si, R′O, NH2, C(O)OH, N3, C═CH, vicinal disubstituted with C(O)CO(O), a cyclic conjugated diene, any salts derived therefrom or any condensation or addition derivative substituent therefrom,
each R′ is independently C1-C18 alkyl, C2-C18 alkenyl, C2-C18 alkynyl, C6-C14 aryl, C7-C18 arylalkyl, C8-C18 arylalkenyl, C8-C18 arylalkynyl, C1-C18 alkoxy, C6-C14 aryloxy, C7-C18 arylalkyloxy, C2-C18 alkenyloxy, C2-C18 alkynyloxy, C8-C18 arylalkenyloxy, C8-C30 arylalkynyloxy, C2-C30 alkylester, C7-C16 arylester, C8-C30 alkylarylester, C3-C18 alkenylester, C3-C18 alkynylester, C3-C18 di- or poly-ether, C3-C18 di- or poly-etherester, C3-C18 di- or poly-ester, C3-C18 di- or poly-amine, or C4-C18 di- or poly-ene, and each R and R′ group is linear, branched, cyclic, polycyclic or any combination thereof;
at least one of the R groups comprises the condensation or addition derivative substituent comprising the coupling unit forming the hydrolytically stable bond between the NHCM and the aptamer,
wherein the condensation or addition derivative substituent is derived from condensation or addition of a —NH2 and —C(O)OH, —N3 and —C═CH; —NH2 and vicinal disubstituted —C(O)CO(O)—, or homocyclic or heterocyclic conjugated diene and —C═CH or —HC═CH2, and
the N-heterocyclic-carbene is achiral, a racemic mixture, partially resolved enantiomer, resolved enantiomer, resolved diastereomers, or a mixture of diastereomers.