Patent ID: 11952632
Assignee: NUCLEIX LTD.
Field: Measurement (Instruments)
Classification: CPC C  G | IPC C  G

Claim 0:
1. A method for detecting a cancer-related mutation in a DNA sample, the method comprising:
(a) subjecting the DNA sample to digestion with a restriction endonuclease to obtain restriction endonuclease-treated DNA;
(b) co-amplifying from the restriction endonuclease-treated DNA a restriction locus comprising a cancer mutation site and a control locus, thereby generating an amplification product for each locus,
(c) calculating a ratio between signal intensities of the amplification products of the restriction locus and the control locus; and
(d) detecting the cancer-related mutation in the DNA sample by comparing the ratio calculated in step (c) to a predefined threshold ratio.