Patent ID: 11912743
Assignee: NOUSCOM AG
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A polynucleotide comprising a sequence encoding a fusion polypeptide, wherein the fusion polypeptide having T-cell response enhancer activity comprises
(a) a fragment of an invariant chain (INV) of a Teleostei comprising between 16 to 27 amino acids of the membrane proximal domain (MPD) of an INV of the Teleostei, wherein the MPD is characterized by the following amino acid sequence (SEQ ID NO: 31):, X1QKX2QIHTLQKX3SX4RX5X6X7QX8TRX9SX10AV wherein X1 is G, D, S or N; X2 is E or Q; X3 is N or S; X4 is D or E; X5 is M or L; X6 is G, N, S or T; X7 is K or R; X8 is L or M; X9 is S, T or A; and X10 is Q or H; and wherein the 16 to 27 amino acids of the MPD are at least 90% identical to SEQ ID NO: 7;
and further comprises
(b) one or more antigens and/or one or more antigenic fragments thereof;
wherein the fusion polypeptide does not comprise the full length INV of a Teleostei.