Patent ID: 11951216
Assignee: REGENERON PHARMACEUTICALS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 15:
16. A method of providing an extended release coating for therapeutic protein comprising:
a. atomizing an aqueous solution comprising a therapeutic protein;
b. spray drying the atomized aqueous solution at a temperature greater than the boiling point of water to remove water in the solution and form a population of therapeutic protein microparticles;
c. coating each therapeutic protein microparticle of the population therapeutic protein microparticles with a biodegradable polymer to form a population of polymer-coated therapeutic protein microparticles, wherein the biodegradable polymer is polyorthoester,
wherein the extended release pharmaceutical composition releases the therapeutic protein for at least 60 days at a steady rate of release, wherein extended release pharmaceutical composition can treat conditions selected from the group consisting of cancers, cardiovascular diseases, vascular conditions, orthopedic disorders, dental disorders, wounds, autoimmune diseases, gastrointestinal disorders and ocular diseases.