Patent ID: 11957794
Assignee: ALBERT-LUDWIGS-UNIVERSITAET FREIBURG
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  B  Y | IPC A  B

Claim 8:
9. A biodegradable multilayer nanocapsule for the delivery of at least one biologically active agent into at least one target cell, wherein said nanocapsule is prepared by:
a. providing a core consisting of CaCO3;
b. coating said core with a first layer of a first biodegradable polymer;
c. depositing onto said first layer at least one biologically active agent;
d. providing a second layer of a second biodegradable polymer over said at least one biologically active agent, wherein said second biodegradable polymer is different from said first biodegradable polymer used in forming said first layer in step b);
e. dissolving said core so as to yield a core-free biodegradable multilayer nanocapsule;
further wherein:
i. said at least one biologically active agent is a nucleic acid, and
ii. said nanocapsule has a diameter of 60 nm to 150 nm.