Patent ID: 11892433
Assignee: THERMO FINNIGAN LLC
Field: Measurement (Instruments)
Classification: CPC G  H | IPC G  H

Claim 11:
12. A method of electrospray ionization of a fluid sample, wherein an electrospray assembly includes a fluid union, a fluid column coupled with a first port, a power source coupled with the fluid union and the first port and configured to apply a voltage to the fluid union sufficient to ionize the fluid sample to form an ionized fluid sample, an electrospray emitter coupled with the fluid union, and a current sensing circuit disposed between the power source and the fluid union, the method comprising:
separating molecules in the fluid sample using the fluid column to produce a separated fluid sample;
transferring the separated fluid sample into the fluid union via the first port,
applying the voltage to the fluid union and to the first port, the voltage at the fluid union and first port being balanced to restrict current leakage from the fluid union;
via the current sensing circuit, measuring an electrical current flow between the power source and the fluid union.