Patent ID: 11912709
Assignee: UNIVERSITY OF MASSACHUSETTS
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 1:
2. The temozolomide compound of claim 1, wherein R1 is of the formula, , wherein in the above formulas,
A is a center of permanent positive charge comprising an ammonium group of the formula —N(R7)3, wherein R7 is a C1-6 alkyl or a center of permanent negative charge comprising a sulfonate group or a carboxylate group;
B is the divalent group comprising a C1-12 alkylene group, a C6-30 arylene or heteroarylene group, or an alkylene oxide group;
C is a center of permanent positive charge comprising a divalent ammonium group or a center of permanent negative charge comprising a divalent phosphate group; and
L2 is a divalent C1-6 alkylene group and is covalently bound to L1 through a thioether bond or a disulfide bond.