Patent ID: 11951105
Assignee: LAKE O'HARA LLC
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 10:
11. A method of initiating treatment of schizophrenia with brexpiprazole in an obese patient who is a CYP2D6 poor metabolizer, comprising:
(a) administering 0.5 mg brexpiprazole twice daily on each of the first 4 days of brexpiprazole treatment;
(b) administering 1 mg brexpiprazole twice daily on each of the next 3 days following step (a); and then
(c) administering 1-2 mg/day of brexpiprazole once daily thereafter;, wherein the obese patient has one or more of the following characteristics:
(i) BMI of at least about 35;
(ii) % IBW of at least about 150%;
(iii) waist size greater than about 42 inches;
(iv) % body fat greater than about 40%;
(v) % android body fat greater than about 40%;
(vi) % gynoid body fat greater than about 40%; or
(vii) total body fat greater than about 40 kg.