Patent ID: 11919881
Assignee: JANSSEN PHARMACEUTICA NV
Field: Organic fine chemistry (Chemistry)
Classification: CPC C | IPC C

Claim 2:
3. The compound of claim 1, wherein
R1 is 5 to 6 membered heterocyclyl; wherein the 5 to 6 membered heterocyclyl is optionally substituted with one to two substituents independently selected from the group consisting of halogen, C1-4alkyl and fluorinated C1-4alkyl;
a is an integer from 1 to 2;
each R2 is independently selected from the group consisting of chloro and fluoro;
R4 is selected from the group consisting of
(b) phenyl; wherein the phenyl is optionally substituted with one to two substituents independently selected from the group consisting of —C(O)OH, —NRCRD and —C(O)—NRCRD; wherein RC is selected from the group consisting of hydrogen, cyclopropyl, 3-hydroxy-cycloprop-1-yl and —C(O)—O—C1-4alkyl; and RD is hydrogen;
(c) 5 membered heterocyclyl; wherein the 5 membered heterocyclyl contains at least one N; optionally contains 1 to 3 additional N; and wherein the 5 membered heterocyclyl is optionally substituted one to two substituents independently selected from the group consisting of C1-4alkyl and fluorinated C1-4alkyl;
and (d) 6 membered heterocyclyl;
R5 is selected from the group consisting of
(a) C1-4alkyl; wherein the C1-4alkyl is optionally substituted with fluorinated C1-4alkoxy;
(b) —CH2—C3-6cycloalkyl;
and (d) —C1-2alkylene-phenyl; wherein the phenyl is optionally substituted with halogen;
R6 and R7 are each hydrogen;
or a stereoisomer, isotopologue, isotopomer, or pharmaceutically acceptable salt or solvate thereof.