Patent ID: 11969468
Assignee: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C  Y | IPC A

Claim 0:
1. An adjuvant for the enhancement of vaccine efficacy, the adjuvant comprising an attenuated derivative of a bacterial pathogen that undergoes lysis in vivo, wherein the bacterial pathogen is a Salmonella spp; wherein the adjuvant comprises a self destructing attenuated Salmonella Typhimurium (S. Typhimurium) bacterium, comprising mutations facilitating lysis in vivo comprising ΔPasdA::TT araC ParaBAD asdA, Δalr, and ΔPdadB66::TT araC ParaBAD dadB, and, optionally, ΔpapP::PIppIpxE.