Patent ID: 11970542
Assignee: FRED HUTCHINSON CANCER CENTER
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A bispecific affinity reagent, comprising:
a first binding domain that binds to a CD38 antigen or a B cell maturation antigen (BCMA), wherein the first binding domain that binds to the CD38 antigen comprises an amino acid sequence included in an amino acid sequence of the bispecific affinity reagent as set forth in any one of SEQ ID NOs: 2, 4, or 6, and wherein the first binding domain that binds the BCMA comprises an amino acid sequence included in an amino acid sequence of the bispecific affinity reagent as set forth in any one of SEQ ID NOs: 8 or 10; and
a second binding domain that binds to a yttrium-DOTA (Y-DOTA) ligand, wherein the second binding domain that binds to the Y-DOTA ligand comprises an amino acid sequence as set forth in any one of SEQ ID NOs: 20-36.