Patent ID: 11881286
Assignee: GENENTECH, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC G  A  C | IPC A  C  G

Claim 0:
1. A method comprising:
processing a sample from a subject to characterize immunoactivity, wherein processing the sample comprises:
(i) generating gene expression level data corresponding to the subject for a predefined set of genes, wherein the generating comprises measuring nucleic acid levels or protein levels in the sample, and wherein for each gene in the predefined set of genes, an expression level of the gene had been identified as being informative of a quantity or a spatial distribution of CD8+ T cells; and
(ii) based on the gene expression level data, (a) determining the quantity of CD8+ T cells in the sample or a portion thereof, or (b) characterizing the spatial distribution of the CD8+ T cells in the sample or a portion thereof;

detecting, based on the gene expression level data and either the quantity or the spatial distribution of the CD8+ T cells, an immunosuppressive tumor microenvironment within the sample or the portion thereof; and
prompting treatment of the subject with an inhibitor of TGFβ.