Patent ID: 11926657
Assignee: MEDIMMUNE LIMITED
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. An isolated binding molecule which specifically binds to influenza A virus and influenza B virus, comprising:
(a) a first binding domain comprising an Fv domain of a first antibody that is capable of binding to influenza A virus hemagglutinin (HA) and neutralizing at least one group 1 subtype and at least 1 group 2 subtype of influenza A virus, wherein the first antibody comprises a VH and a VL selected from:
(i) a VH at least 95% identical to SEQ ID NO.: 7 and a VL at least 95% identical to SEQ ID NO.: 2; and
(ii) a VH at least 95% identical to SEQ ID NO.: 17 and a VL at least 95% identical to SEQ ID NO.: 12; and
(b) a second binding domain comprising an scFv of a second antibody that is capable of binding to influenza B virus hemagglutinin (HA) and neutralizing influenza B virus in at least two phylogenetically distinct lineages, wherein the second antibody comprises a VH and a VL selected from:
(i) a VH at least 95% identical to SEQ ID NO.: 27 and a VL at least 95% identical to SEQ ID NO.: 22;
(iv) a VH at least 95% identical to SEQ ID NO.: 43 and a VL at least 95% identical to SEQ ID NO.: 38; and
(vii) a VH at least 95% identical to SEQ ID NO.: 59 and a VL at least 95% identical to SEQ ID NO.: 54.