Patent ID: 11912715
Assignee: NOVARTIS AG
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 10:
11. A method of treating a viral infection, comprising administering to a subject a therapeutically effective amount of a compound of formula (I):, or a pharmaceutically acceptable salt thereof, wherein:
R1 is H, halo, CN, COOR*, —CONR*2, or C1-C6 alkyl optionally substituted with one or two groups selected from —OR* and —NR*2, C1-C4 haloalkyl;
R* is independently at each occurrence H or C1-C6 alkyl optionally substituted with —OR or —NR2;
Z1 is N, and Z2 is C(R)2;
or Z1 is CH, and Z2 is NR, O, S, or CH2;
Z3 is CH2, Q, —CH2—CH2—, -Q-CH2—, —CH2-Q-, —CH2-Q-CH2— or —CH2—CH2—CH2—;
Q is selected from —NR—, O, S, SO, and SO2;
R2 is selected from H, halo, CN, C1-4 alkyl optionally substituted with up to three groups independently selected from halo, CN, C1-4 alkyl, —OR, C1-4 haloalkoxy, —NR2, and C1-C4 haloalkyl;
each R3 is a substituent optionally present on any carbon atom of the ring containing Z2 and Z3, and is independently selected from —OR, C1-4 haloalkyl, C1-4 haloalkoxy, oxo, CN, —NR2, and C1-4 alkyl optionally substituted with up to three groups independently selected from halo, CN, C1-4 alkyl, —OR, C1-4haloalkoxy, —NR2, and C1-4haloalkyl;
n is 0-2;
Ar1 and Ar2 each independently represent phenyl or a 5-6 membered heteroaryl ring containing 1-3 heteroatoms selected from N, O and S as ring members, and are each independently substituted with up to three groups selected from halo, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy, C1-4 haloalkoxy, C2-4 alkyne, and CN;
and Ar1 and Ar2 are optionally linked together by a bridge of the formula —C(RL)2-L- to form a tricyclic group, wherein Ar1 and Ar2 are each optionally substituted by up to two groups independently selected from halo, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy, C1-4 haloalkoxy, C2-4 alkyne, and CN;
R is independently at each occurrence H or C1-C4 alkyl optionally substituted with up to three groups independently selected from halo, OH, oxo, C1-4 alkyl, C1-4 alkoxy, C1-4 haloalkoxy, and C1-4 haloalkyl;
L is selected from S, S═O, O, NR, C(RL)2 and CF2; and
each RL is independently H or C1-2 alkyl.