Patent ID: 11857571
Assignee: TRUSTEES OF DARTMOUTH COLLEGE
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A polynucleotide encoding an anti-major histocompatibility complex class I chain-related gene A (MICA) chimeric antigen receptor (CAR) comprising an anti-MICA antibody or antigen binding fragment thereof, wherein the anti-MICA antibody or antigen binding fragment thereof comprises a heavy chain variable region comprising the heavy chain complementarity determining regions 1, 2 and 3 (HCDR1, HCDR2 and HCDR3) respectively comprising the amino acid sequences of SEQ ID NO: 35; SEQ ID NO: 36; and SEQ ID NO: 22, and a light chain variable region comprising the light chain complementarity determining regions 1, 2 and 3 (LCDR1, LCDR2 and LCDR3) respectively comprising the amino acid sequences of SEQ ID NO: 26, SEQ ID NO: 28; and SEQ ID NO: 37.