Patent ID: 11970531
Assignee: KYOWA KIRIN CO., LTD.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  G  A | IPC A  C

Claim 3:
4. The method according to claim 1, wherein the monoclonal antibody or the antibody fragment thereof is selected from the following (a) to (w):
(a) a monoclonal antibody comprising a VH comprising an amino acid sequence of SEQ ID NO: 94 and a VL comprising an amino acid sequence of SEQ ID NO: 73, or an antibody fragment thereof;
(b) a monoclonal antibody comprising a VH comprising an amino acid sequence of SEQ ID NO: 95 and a VL comprising an amino acid sequence of SEQ ID NO: 73, or an antibody fragment thereof;
(c) a monoclonal antibody comprising a VH comprising an amino acid sequence of SEQ ID NO: 91 and a VL comprising an amino acid sequence of SEQ ID NO: 75, or an antibody fragment thereof;
(d) a monoclonal antibody comprising a VH comprising an amino acid sequence of SEQ ID NO: 98 and a VL comprising an amino acid sequence of SEQ ID NO: 75, or an antibody fragment thereof;
(e) a monoclonal antibody comprising a VH comprising an amino acid sequence of SEQ ID NO: 89 and a VL comprising an amino acid sequence of SEQ ID NO: 77, or an antibody fragment thereof;
(f) a monoclonal antibody comprising a VH comprising an amino acid sequence of SEQ ID NO: 97 and a VL comprising an amino acid sequence of SEQ ID NO: 77, or an antibody fragment thereof;
(g) a monoclonal antibody comprising a VH comprising an amino acid sequence of SEQ ID NO: 97 and a VL comprising an amino acid sequence of SEQ ID NO: 78, or an antibody fragment thereof;
(h) a monoclonal antibody comprising a VH comprising an amino acid sequence of SEQ ID NO: 98 and a VL comprising an amino acid sequence of SEQ ID NO: 78, or an antibody fragment thereof;
(i) a monoclonal antibody comprising a VH comprising an amino acid sequence of SEQ ID NO: 91 and a VL comprising an amino acid sequence of SEQ ID NO: 79, or an antibody fragment thereof;
(j) a monoclonal antibody comprising a VH comprising an amino acid sequence of SEQ ID NO: 95 and a VL comprising an amino acid sequence of SEQ ID NO: 79, or an antibody fragment thereof;
(k) a monoclonal antibody comprising a VH comprising an amino acid sequence of SEQ ID NO: 98 and a VL comprising an amino acid sequence of SEQ ID NO: 79, or an antibody fragment thereof;
(l) a monoclonal antibody comprising a VH comprising an amino acid sequence of SEQ ID NO: 89 and a VL comprising an amino acid sequence of SEQ ID NO: 81, or an antibody fragment thereof;
(m) a monoclonal antibody comprising a VH comprising an amino acid sequence of SEQ ID NO: 91 and a VL comprising an amino acid sequence of SEQ ID NO: 81, or an antibody fragment thereof;
(n) a monoclonal antibody comprising a VH comprising an amino acid sequence of SEQ ID NO: 95 and a VL comprising an amino acid sequence of SEQ ID NO: 81, or an antibody fragment thereof;
(o) a monoclonal antibody comprising a VH comprising an amino acid sequence of SEQ ID NO: 97 and a VL comprising an amino acid sequence of SEQ ID NO: 81, or an antibody fragment thereof;
(p) a monoclonal antibody comprising a VH comprising an amino acid sequence of SEQ ID NO: 98 and a VL comprising an amino acid sequence of SEQ ID NO: 81, or an antibody fragment thereof;
(q) a monoclonal antibody comprising a VH comprising an amino acid sequence of SEQ ID NO: 94 and a VL comprising an amino acid sequence of SEQ ID NO: 85, or an antibody fragment thereof;
(r) a monoclonal antibody comprising a VH comprising an amino acid sequence of SEQ ID NO: 95 and a VL comprising an amino acid sequence of SEQ ID NO: 85, or an antibody fragment thereof;
(s) a monoclonal antibody comprising a VH comprising an amino acid sequence of SEQ ID NO: 97 and a VL comprising an amino acid sequence of SEQ ID NO: 85, or an antibody fragment thereof;
(t) a monoclonal antibody comprising a VH comprising an amino acid sequence of SEQ ID NO: 98 and a VL comprising an amino acid sequence of SEQ ID NO: 85, or an antibody fragment thereof;
(u) a monoclonal antibody comprising a VH comprising an amino acid sequence of SEQ ID NO: 94 and a VL comprising an amino acid sequence of SEQ ID NO: 87, or an antibody fragment thereof;
(v) a monoclonal antibody comprising a VH comprising an amino acid sequence of SEQ ID NO: 97 and a VL comprising an amino acid sequence of SEQ ID NO: 87, or an antibody fragment thereof; and
(w) a monoclonal antibody comprising a VH comprising an amino acid sequence of SEQ ID NO: 98 and a VL comprising an amino acid sequence of SEQ ID NO: 87, or an antibody fragment thereof.