Patent ID: 11904009
Assignee: SANOFI
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C  Y | IPC A  C

Claim 0:
1. A ferritin protein comprising a mutation replacing an internal cysteine with a non-cysteine amino acid, wherein the internal cysteine is at position 30 of the H. pylori ferritin sequence of SEQ ID NO: 209, or is at a position that corresponds to position 30 of the H. pylori ferritin sequence of SEQ ID NO: 209 as determined by pair-wise or structural alignment, and further comprising i) a mutation replacing a surface-exposed amino acid with a cysteine, ii) an N- or C-terminal linker comprising a cysteine; or iii) one or more immune-stimulatory moieties linked to the ferritin protein via a surface-exposed amino acid.