Patent ID: 11925684
Assignee: AMGEN RESEARCH (MUNICH) GMBH
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 15:
16. A bispecific single chain antibody comprising:
(i) a first binding domain which binds to primate CD3 comprising CDR-L1 (SEQ ID NO: 118), CDR-L2 (SEQ ID NO: 117), and CDR-L3 (SEQ ID NO: 116) and CDR-H1 (SEQ ID NO: 115), CDR-H2 (SEQ ID NO: 114) and CDR-H3 (SEQ ID NO: 112) or (SEQ ID NO: 113),
wherein the first binding domain comprises a single chain antibody fragment (scFv) comprising:
(a) the amino acid sequence set forth in SEQ ID NO: 194; or
(b) an amino acid sequence encoded by the nucleotide sequence set forth in SEQ ID NO: 193; and

(ii) a second binding domain binding to a cell surface antigen.