Patent ID: 11872288
Assignee: PHILOGEN S.P.A.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A

Claim 0:
1. A method of treating a brain tumor in a patient, comprising administering a TNFα immunoconjugate in combination with chemotherapy to the patient, wherein the TNFα immunoconjugate comprises TNFα linked to an antibody molecule comprising L19 complementarity determining regions (CDRs), wherein the L19 CDRs are:, SEQ ID NO: 1

VH CDR1
SFSMS

 

SEQ ID NO: 2

VH CDR 2
SISGSSGTTYYADSVKG

 

SEQ ID NO: 3

VH CDR 3
PFPYFDY

 

SEQ ID NO: 4

VL CDR 1
RASQSVSSSFLA

 

SEQ ID NO: 5

VL CDR 2
YASSRAT, and

 

SEQ ID NO: 6

VL CDR 3
QQTGRIPPT;

and the chemotherapy is lomustine, wherein said combination increases brain tumor necrosis and Progression Free Survival (PFS) in said patient and said brain tumor is a glioma.