Patent ID: 11957760
Assignee: ELUCIDA ONCOLOGY, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 1:
2. A nanoparticle-drug conjugate (NDC) comprising:
(a) a silica nanoparticle;
(b) polyethylene glycol (PEG) that is covalently bonded to the surface of the silica nanoparticle;
(c) a targeting ligand comprising folic acid, wherein the targeting ligand is attached to the silica nanoparticle through a spacer group; and
(d) a structure of Formula (S-1):, , wherein
Payload comprises exatecan;
Linker comprises a protease-cleavable linker, wherein the exatecan is released upon cleavage of the linker; and
the silicon atom (Si) is a part of the silica nanoparticle.