Patent ID: 11958905
Assignee: JCR PHARMACEUTICALS CO., LTD.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 20:
21. A nucleic acid molecule encoding a fusion protein of brain-derived neurotrophic factor (BDNF) and an anti-human transferrin receptor (anti-hTfR) scFv antibody, wherein the fusion protein comprises BDNF linked to the anti-hTfR scFv antibody with a linker, wherein the anti-hTfR scFv antibody comprises a light chain variable region (LCVR) comprising three complementarity-determining regions (LCDR1-3) and a heavy chain variable region (HCVR) comprising three complementarity-determining regions (HCDR1-3), wherein the LCDR1 comprises the amino acid sequence SEQ ID NO:16, the LCDR2 comprises the amino acid sequence of SEQ ID NO:18, the LCDR3 comprises the amino acid sequence of SEQ ID NO:20, the HCDR1 comprises the amino acid sequence SEQ ID NO:88, the HCDR2 comprises the amino acid sequence SEQ ID NO:90, and the HCDR3 comprises the amino acid sequence SEQ ID NO:92, wherein the BDNF is a human BDNF, and wherein the C-terminus of the BDNF is linked to the N-terminus of the HCVR via a first linker and the C-terminus of the HCVR is linked to the N-terminus of the LCVR via a second linker.