Patent ID: 11879017
Assignee: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A  G | IPC A  C  G

Claim 0:
1. A method of treating cancer in a mammal, the method comprising administering to the mammal a population of cells in an amount effective to treat cancer in the mammal, wherein the population of cells comprises one or more T cells expressing a chimeric antigen receptor (CAR) having antigen specificity for epidermal growth factor receptor variant III (EGFRvIII), wherein the CAR comprises an amino acid sequence selected from the group consisting of SEQ ID NOS: 10-11, wherein the cancer is an EGFRvIII positive cancer, and wherein the population of cells is autologous to the mammal.