Patent ID: 11920166
Assignee: RENEW BIOPHARMA, INC.
Field: Biotechnology (Chemistry)
Classification: CPC C | IPC C

Claim 0:
1. A variant cannabinoid synthase or an active fragment thereof comprising a non-naturally occurring amino acid sequence relative to a wild-type cannabinoid synthase or an active fragment thereof,
wherein the variant cannabinoid synthase is:
(i) a cannabidiolic acid (CBDA) synthase comprising an amino acid sequence having greater than 80% sequence identity to SEQ ID NO: 1043 and an amino acid substitution at at least one amino acid position selected from the group consisting of: H69, C180, M256, R295, Q376, N377, A414, and I445;
(ii) a tetrahydrocannabinolic acid (THCA) synthase comprising an amino acid sequence having greater than 80% sequence identity to SEQ ID NO: 1044 and an amino acid substitution at at least one amino acid position selected from the group consisting of: Q69, G180, I257, K296, K377, K378, V415, and T446; or
(iii) a cannabichromenic acid (CBCA) synthase comprising an amino acid sequence having greater than 80% sequence identity to SEQ ID NO: 1045 and an amino acid substitution at at least one amino acid position selected from the group consisting of: Q69, G180, I257, R296, K377, K378, V415, and T446.