Patent ID: 11918553
Assignee: OSTENTUS THERAPEUTICS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 0:
1. A pharmaceutical composition comprising:
(i) 70% to 99% of a solvent comprising a pharmaceutically acceptable monohydric alcohol selected from the group consisting of ethanol, n-propanol, isopropanol, isobutanol, and 2-methyl-2-butanol, or any combination thereof; and
(ii) one or more anti-oncogenic phytochemicals comprising one or more compounds of the chemical formula, or a stereoisomer thereof,
wherein:
X is OH, OCH3, or OCH2CH3;
R1 is absent;
R2 is H, CH3, or CH2CH3; and
R3 is:, or a stereoisomer thereof,
wherein:
is a single bond or a double bond; and
a is bonded to C(OR1)OR2 and b is bonded to X; and

wherein the pharmaceutical composition is produced by a method comprising the following steps:

(a) preparing a macerate comprising a plant material from Baccharis coridifolia and a solvent comprising 70% to 100% of the pharmaceutically acceptable monohydric alcohol;
wherein the pharmaceutically acceptable monohydric alcohol is selected from the group consisting of ethanol, n-propanol, isopropanol, isobutanol, and 2-methyl-2-butanol, or any combination thereof;
(b) incubating the macerate prepared in step (a) above in a closed, light-tight container at a temperature in the range of 15° C. to 22° C. over a period of at least 21 days, in order to solubilize the one or more anti-oncogenic phytochemicals comprising the one or more compounds of the chemical formula (I) above; and
(c) purifying the macerate incubated in step (b) above, in order to remove any solid plant material and produce an extract comprising the pharmaceutical composition above comprising:
(i) 70% to 99% of a solvent comprising a pharmaceutically acceptable monohydric alcohol selected from the group consisting of ethanol, n-propanol, isopropanol, isobutanol, and 2-methyl-2-butanol, or any combination thereof; and
(ii) one or more anti-oncogenic phytochemicals comprising one or more compounds of the chemical formula (I):, or a stereoisomer thereof,
wherein:
X is OH, OCH3, or OCH2CH3;
R1 is absent;
R2 is H, CH3, or CH2CH3; and
R3 is:, or a stereoisomer thereof,
wherein:
is a single bond or a double bond; and
a is bonded to C(OR1)OR2 and b is bonded to X.