Patent ID: 11883386
Assignee: AKEBIA THERAPEUTICS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C  Y | IPC A  C

Claim 0:
1. A process for preparing a compound having the formula:, comprising:
(a) reacting a 4-chlorophenyl boronic acid:, with methyl 4-bromo-2-methoxybenzoate:, in the presence of a catalyst to form 4′-chloro-3-methoxy-biphenyl-4-carboxylic acid methyl ester:, (b) reacting 4′-chloro-3-methoxy-biphenyl-4-carboxylic acid methyl ester obtained from step (a) with lithium hydroxide to form 4′-chloro-3-methoxy-biphenyl-4-carboxylic acid:, and
(c) reacting 4′-chloro-3-methoxy-biphenyl-4-carboxylic acid obtained from step (b) with glycine ethyl ester, in the presence of coupling agents to form [(4′-chloro-3-methoxy-biphenyl-4-carbonyl)-amino]-acetic acid ethyl ester:,