Patent ID: 11878280
Assignee: TRUCAPSOL LLC
Field: Pharmaceuticals (Chemistry)
Classification: CPC B  A  C | IPC A  B  C

Claim 0:
1. A method for preparing a composition comprising controlled release particles, said method comprising the sequential steps of:
(a) preparing an oil phase, wherein the oil phase comprises:
(i) at least one hydrophobic active ingredient, at least one isocyanate, at least one epoxy, at least one organofunctional silane, and optionally a plasticizer; or
(ii) at least one hydrophobic active ingredient, at least one isocyanate, at least one epoxy, at least one organofunctional silane, at least one pre-reacted natural material resin, and optionally a plasticizer;
(b) preparing an aqueous phase comprising an emulsifier;
(c) combining the oil phase and the aqueous phase to emulsify the at least one hydrophobic active ingredient and to provide an aqueous suspension of the at least one hydrophobic active ingredient;
(d) adding to the aqueous suspension at least one amine moiety containing material to react with the at least one isocyanate, the at least one epoxy, or the at least one organofunctional silane to provide a barrier;
(e) heating the aqueous suspension;
(f) adding a natural material to the aqueous suspension to provide a microcapsule having hydroxyl moieties or amine moieties on a surface thereof;
(g) adding an aldehyde to the aqueous suspension to react with the hydroxyl moieties or amine moieties on the surface of the microcapsule; and
(h) adding structuring agents to the aqueous suspension to provide the controlled release particles homogeneously suspended in an aqueous dispersion.