Patent ID: 11970533
Assignee: SPARX BIOSCIENCE LIMITED
Field: Biotechnology (Chemistry)
Classification: CPC C | IPC C

Claim 10:
11. The bispecific antibody of claim 4,
wherein the second VL of the second antigen-binding moiety that binds human PD-L1 comprises the amino acid sequence of: EIVLTQSPGTLSLSPGERATLSCRASQRVSSSYLAWYQQKPGQX1PRLLIYDASSRATGIPDR FSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSLPWTFGX2GTKVEIK (SEQ ID NO 171), in which X1 represents Alanine (A), or Cysteine (C); and X2 represents Glutamine (Q), or Cysteine (C); or
wherein the second VH of the second antigen-binding moiety that binds human PD-L1 comprises the amino acid sequence of: EVX1LVESGX2GLVQPGGSLRLSCAASGFTFSRYWMSWVRQAPGKX3LEWVANIKQDGSEK YYVDSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCAREGGWFGELAFDYWGX4GTL VTVSS (SEQ ID NO 170), in which X1 represents Glutamine (Q), or Cysteine (C); X2 represents Glycine (G), or Cysteine (C); X3 represents amino acid residues Glycine (G), or Cysteine (C); and X4 represents Glutamine (Q), or Cysteine (C).