Patent ID: 11931429
Assignee: RAMOT AT TEL-AVIV UNIVERSITY LTD.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C  Y | IPC A  C

Claim 9:
10. A method for diagnostics or in vivo imaging comprising:
applying a composition according to claim 9 to a biological tissue or administering a composition according to claim 9 to a subject, wherein R4 of the conjugate of formula IIIa/IIIb is a caging group cleavable by an analyte, wherein upon exposure to said analyte, group R4 is cleaved from the compound of formula IIIa/IIIb, thereby generating a phenolate-dioxetane compound and initiating a chemically initiated electron exchange luminescence (CIEEL) mechanism, which results in excitation of the fluorophore group Z of said conjugate that is then decays to its ground-state through emission of light; and
imaging to detect the emission of light.