Patent ID: 11866743
Assignee: TELEDYNE FLIR DETECTION, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 16:
17. A method for treating or ameliorating one or more symptoms of chemical warfare agent exposure in a patient, the method comprising,
administering to the patient a first effective amount of a composition comprising:
an organophosphorus hydrolase (OPH) protein:polymer conjugate, comprising an enzymatically-active, genetically-modified OPH protein, selected from the group consisting of OPH YT protein, OPH C23 protein, and OPH IVH3 protein conjugated to at least a first polymer, wherein the polymer has a molecular weight in a range of 175 kDa to 222 kDa and comprises a PEGMA chain;
wherein an in vivo kcat/km of the protein:polymer conjugate is one or both of:
a) ≥1×107 for at least one G-series chemical warfare agent;
b) ≥1×105 for at least one V-series chemical warfare agent.