Patent ID: 11897939
Assignee: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 22:
23. A method for inhibiting a sexually transmitted pathogen in mucus of a subject's reproductive tract, the method comprising immobilizing the pathogen by administering to the subject a population of recombinant antibody in which at least 40% comprise an oligosaccharide having a GOF glycosylation pattern comprising a biantennary core glycan structure of Manα1-6(Manα1-3)Manβ1-→GlcNAcβ1-4GlcNAcβ1 with a fucose reside and a terminal N-acetylglucosamine, wherein the terminal N-acetylglucosamine is on each branch, wherein the recombinant antibody has a specific affinity for the pathogen so that the recombinant antibody is trapped in the subject's mucus, the recombinant antibody comprising a human or humanized Fc region, wherein the recombinant antibody comprises an oligosaccharide having a glycosylation pattern that enhances the trapping potency of the recombinant antibody in mucus.