Patent ID: 11912723
Assignee: QUANTA THERAPEUTICS, INC.
Field: Organic fine chemistry (Chemistry)
Classification: CPC A  C | IPC C

Claim 0:
1. A compound of Formula (II):, , or a pharmaceutically acceptable salt thereof wherein:
M is selected from O, and NR3;
R1 is selected from 7- to 10-membered heterocycle, each of which are optionally substituted with one or more substituents independently selected from halogen, —B(OR20)2, —OR20, —SR20, —S(O)2(R20), —S(O)2N(R20)2, —S(O)N(R20)2, —S(O)R20(═NR20), —NR20S(O)2R20, —C(O)N(R20)2, —C(═NR20)N(R20)2, —C(O)NR20OR20, —N(R20)C(O)R20, —N(R20)C(O)N(R20)2, —N(R20)C(O)OR20, —N(R20)2, —C(O)R20, —C(O)OR20, —OC(O)R20, —OC(O)N(R20)2, —NO2, ═O, ═N(R20), ═NO(R20), —CN, —NHCN, C1-6 alkyl-N(R20)2, C1-6 aminoalkyl, C1-6 alkoxy, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, C1-6 haloalkyl, C1-6 alkyl-SO2R20, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-C12 carbocycle and 5- to 12-membered heterocycle, wherein the C3-C12 carbocycle and 5- to 12-membered heterocycle are each optionally substituted independently with one or more R1*;
each R1* is independently selected from halogen, —B(OR20)2, —OR20, —SR20, —S(O)2(R20), —S(O)2N(R20)2, —S(O)N(R20)2, —S(O)R20(═NR20), —NR20S(O)2R20, —C(O)N(R20)2, —C(O)NR20OR20, —N(R20)C(O)R20, —N(R20)C(O)N(R20)2, —N(R20)C(O)OR20, —N(R20)2, —C(O)R20, —C(O)OR20, —OC(O)R20, —OC(O)N(R20)2, —NO2, =0, ═N(R20), ═NO(R20), —CN, —NHCN, C1-6 alkyl-N(R20)2, C1-6 aminoalkyl, C1-6 alkoxy, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, C1-6 haloalkyl, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-C12 carbocycle;
Y is O;
R2 is selected from -L-N(R21)2 and -L-heterocycle, wherein the heterocycle portion of -L-heterocycle, is optionally substituted with one or more R6,
each L is independently selected from a C1-C4 alkylene optionally substituted with one or more substituents selected from hydroxy, C1-C4 hydroxyalkyl, C1-C4 alkyl, C3-C6 carbocycle, and 3- to 8-membered heterocycle, wherein the C3-C6 carbocycle and 3- to 8-membered heterocycle are each optionally substituted with one or more substituents selected from halogen, —OH, —NO2, ═O, ═S, —CN, C1-6 aminoalkyl, C1-6 alkoxy, C1-6 hydroxyalkyl, C1-6 haloalkyl; and wherein optionally two substituents on the same carbon atom of L come together to form a C3-C6 carbocycle or 3- to 8-membered heterocycle, wherein the C3-C6 carbocycle and 3- to 8-membered heterocycle are each optionally substituted with one or more substituents selected from halogen, —OH, —NO2, ═O, ═S, —CN, C1-6 aminoalkyl, C1-6 alkoxy, C1-6 hydroxyalkyl, C1-6 haloalkyl;
R3 is selected from hydrogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 alkyl-N(R20)2, C1-6 aminoalkyl, C1-6 alkoxy, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, C1-6 haloalkyl, C1-6 alkoxyalkyl, C3-12 carbocycle, and 3- to 12-membered heterocycle, wherein C3-12 carbocycle and 3- to 12-membered heterocycle are each optionally substituted with one or more substituents independently selected from halogen, —OH, —CN, —NO2, —NH2, —N(C1-6 alkyl)2, C1-10 alkyl, —C1-10 haloalkyl, —O—C1-10 alkyl, oxo, C3-12 carbocycle, and 3- to 12-membered heterocycle;
n is selected from 0 to 2;
each R4 is independently selected from C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, oxo, hydroxyl, halogen, C3-12 carbocycle, and 3- to 12-membered heterocycle, wherein the C1-C6 alkyl, C3-12 carbocycle, and 3- to 12-membered heterocycle are each optionally substituted with one or more substituents independently selected from cyano, halogen, OR5, and N(R5)2;
each R5 is independently selected from hydrogen and C1-C6 alkyl;
each R6 is independently selected from halogen, hydroxy, C1-C3 hydroxyalkyl, C1-C3 alkyl, oxo, C1-C3 haloalkyl, C1-C3 alkoxy, cyano, ═CH2, ═NO—C1-C3 alkyl, C1-C3 aminoalkyl, —N(R5)S(O)2(R5), -Q-phenyl, -Q-phenylSO2F, —NHC(O)phenyl, —NHC(O)phenylSO2F, C1-C3 alkyl substituted pyrazolyl, tert-butyldimethylsilyloxyCH2-, —N(R5)2, (C1-C3 alkoxy)C1-C3 alkyl-, (C1-C3 alkyl)C(═O), oxo, (C1-C3 haloalkyl)C(═O)—, —SO2F, (C1-C3 alkoxy)C1-C3 alkoxy, —CH2OC(O)N(R5)2, —CH2NHC(O)OC1-C6 alkyl, —CH2NHC(O)N(R5)2, —CH2NHC(O)C1-C6 alkyl, —CH2(pyrazolyl), —CH2NHSO2C1-C6 alkyl, —CH2OC(O)heterocycle, —OC(O)N(R5)2, —OC(O)NH(C1—C3 alkyl)O(C1-C3 alkyl), —OC(O)NH(C1-C3 alkyl)O(C1-C3 alkyl)phenyl(C1-C3 alkyl)N(CH3)2, —OC(O)NH(C1-C3 alkyl)O(C1-C3 alkyl)phenyl, —OC(O)heterocycle, —O—C1-C3 alkyl, and —CH2heterocycle, wherein the phenyl of —NHC(O)phenyl and —OC(O)NH(C1-C3 alkyl)(C1-C3 alkyl)phenyl are each optionally substituted with one or more substituents selected from —C(O)H and OH, and wherein the alkyl of —O—C1-C3 alkyl is optionally substituted with substituents selected from heterocycle, oxo and hydroxy; and wherein the heterocycle of -CH2heterocyclyl is optionally substituted with oxo;
each Q is independently selected from a bond, S, and O;
each R20 is independently selected from hydrogen; and C1-6 alkyl, C3-12 carbocycle, and 3- to 12-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, —OH, —CN, —NO2, —NH2, —N(C1-6 alkyl)2, C1-10 alkyl, —C1-10 haloalkyl, —O—C1-10 alkyl, oxo, ═NH, C3-12 carbocycle, and 3- to 12-membered heterocycle;
each R21 is independently selected from hydrogen; and C1-6 alkyl, C3-12 carbocycle, and 3- to 12-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, —OH, —CN, —NO2, —NH2, —N(C1-6 alkyl)2, C1-10 alkyl, —C1-10 haloalkyl, —O—C1-10 alkyl, oxo, C3-12 carbocycle, and 3- to 12-membered heterocycle; and
B is selected from a heterocycle and carbocycle, wherein the heterocycle and carbocycle is are each optionally substituted with one or more substituents independently selected from halogen, cyano, hydroxy, ═O, —NO2, C1-C4 alkyl, C1-6 aminoalkyl, —S—C1-C3 alkyl, C2-C4 alkenyl, C2-C4 alkynyl, C2-C4 hydroxyalkynyl, C1-C3 cyanoalkyl, triazolyl, C1-C3 haloalkyl, —O—C1-C3 haloalkyl, —S—C1-C3 haloalkyl, C1-C3 alkoxy, C1-C3 hydroxyalkyl, —CH2C(═O)N(R5)2, —C3-C4 alkynyl(NR5)2, —N(R5)2, (C1-C3 alkoxy)haloC1-C3 alkyl-, C1-6 alkyl-N(R20)2, C3-C12 carbocycle and 5- to 12-membered heterocycle, wherein C3-C12 carbocycle and 5- to 12-membered heterocycle are each optionally substituted with one or more substituents selected from halogen, —OH, —NO2, —NH2, ═O, ═S, —CN, C1-6 alkyl-N(R20)2, C1-6 aminoalkyl, C1-6 alkoxy, C1-6 hydroxyalkyl, C1-6 haloalkyl.