Patent ID: 11912767
Assignee: REGENERON PHARMACEUTICALS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A bispecific antigen-binding molecule comprising a first antigen-binding domain that specifically binds human CD28, and a second antigen-binding domain that specifically binds human EGFR,
(a) wherein the first antigen-binding domain that specifically binds human CD28 comprises three heavy chain complementarity determining regions (HCDR1, HCDR2 and HCDR3) and three light chain complementarity determining regions (LCDR1, LCDR2 and LCDR3),
wherein the HCDR1 of the first antigen-binding domain comprises an amino acid sequence of SEQ ID NO: 12; the HCDR2 of the first antigen-binding domain comprises an amino acid sequence of SEQ ID NO: 6; the HCDR3 of the first antigen-binding domain comprises an amino acid sequence of SEQ ID NO: 14, the LCDR1 of the first antigen-binding domain comprises an amino acid sequence SEQ ID NO: 18, the LCDR2 of the first antigen-binding domain comprises an amino acid sequence SEQ ID NO: 20, and the LCDR3 of the first antigen-binding domain comprises an amino acid sequence SEQ ID NO: 22; and
(b) wherein the second antigen-binding domain that specifically binds human EGFR comprises three heavy chain complementarity determining regions (HCDR1, HCDR2 and HCDR3) and three light chain complementarity determining regions (LCDR1, LCDR2 and LCDR3),
wherein
the HCDR1 of the second antigen-binding domain comprises an amino acid sequence of SEQ ID NO: 4, the HCDR2 of the second antigen-binding domain comprises an amino acid sequence of SEQ ID NO: 6, the HCDR3 of the second antigen-binding domain comprises an amino acid sequence of SEQ ID NO: 8, the LCDR1 of the second antigen-binding domain comprises an amino acid sequence of SEQ ID NOs: 18, the LCDR2 of the second antigen-binding domain comprises an amino acid sequence of SEQ ID NO: 20, and the LCDR3 of the second antigen-binding domain comprises an amino acid sequence of SEQ ID NO: 22.