Patent ID: 11897913
Assignee: NUCANA PLC
Field: Organic fine chemistry (Chemistry)
Classification: CPC C  Y | IPC C

Claim 0:
1. A process for the preparation of NUC-7738 (I), , the process comprising steps b), c), d), e) and f):
b) treating a compound of formula (VI) with a hydride reducing agent to provide a compound of formula (V), c) introducing the protecting group P2 onto the 2′ hydroxy group of a compound of formula (V) to provide a compound of formula (II), d) removing the protecting group P1 from a compound of formula (II) to provide 2′-protected Cordycepin (I), wherein P1 and P2 are silyl protecting groups and P3 and P4 are each independently selected from H and a protecting group;
e) converting the compound of formula (I) into a compound of formula (IV), , (IV); and
f) removing protecting group P2 and, where P3 and P4 are protecting groups, removing P3 and P4 to provide NUC-7738;
wherein the overall yield of steps b), c), and d) is 70%-100%.