Patent ID: 11878050
Assignee: TEXAS TECH UNIVERSITY SYSTEM
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  Y | IPC A

Claim 0:
1. A method for reducing biofilm present on a surface of an animal or a subject, wherein the method comprises:
contacting the biofilm with a multilayered dressing, wherein a first layer comprises glycoside hydrolases that target α-1,4, β-1,4, and β-1,3 glycosidic linkages released first, followed by release of an antibiotic, wherein the antibiotic kills pathogenic bacteria after release from a biofilm and the antibiotic activity of the antibiotic is increased in the presence of the glycoside hydrolases, wherein the sequential release of the glycoside hydrolases followed by the antibiotic reduces dispersal of the pathogenic bacteria from the biofilm,
wherein the biofilm is a biofilm-related infection that is on or at a wound, burn infection, keratitis, on a catheter, on a bioprosthetic, an indwelling medical device, a lung, a chronic pulmonary disease, or a lung infection of the animal or subject, and
wherein the biofilm-related infection is caused by pathogenic bacteria selected from[,] P. aeruginosa, S. aureus, E. coli, Aeromonas spp., Enterobacteriaceae spp., Candida spp., Aspergillus spp., Acinetobacter spp., T. asahii, B. cineria, or Fusarium spp, and the biofilm that is a Pel-dependent, a Psl-dependent, a PNAG-dependent, or a GAG-dependent biofilm.