Patent ID: 11921020
Assignee: UNIVERSITY OF IOWA RESEARCH FOUNDATION
Field: Measurement (Instruments)
Classification: CPC G  B  C | IPC B  C  G

Claim 18:
19. A method for purifying viable cancerous cells in a fluid preparation comprising viable circulating tumor cells viable normal cells, and extracellular calcium, wherein the viable circulating tumor cells have an induced fluid shear stress resistance due to one or more pulses of fluid shear stress experience in vivo such that the magnitude of shear stress required to kill the viable cancerous cells is greater than the magnitude of shear stress required to kill the viable normal cells, the method comprising:
applying one or more additional pulses of fluid shear stress to the preparation comprising the fluid shear stress-resistant viable circulating tumor cells, said fluid shear stress sufficient to selectively kill the viable normal cells relative to the viable cancerous cells, whereby the ratio of viable circulating tumor cells to viable normal cells in the preparation is at least doubled.