Patent ID: 11964050
Assignee: PHARMOSA BIOPHARM INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 4:
5. A pharmaceutical composition, comprising liposomes, said liposomes comprising:
a. a lipid bilayer formed of a first phospholipid, a second phospholipid, and cholesterol, wherein the first phospholipid is hydrogenated soy phosphatidylcholine (HSPC), dipalmitoyl phosphatidylcholine (DPPC), distearyloyl phosphatidylcholine (DSPC), diarachidoyl phosphatidylcholine, dimyristoyl phosphatidylcholine (DMPC) or any combination thereof and the second phospholipid is distearyloylphosphatidylglycerol (DSPG)or PEG-DSPE; and
b. an internal aqueous medium inside the lipid bilayer, the internal aqueous medium comprising a bicarbonate salt with a concentration about 200 mM to about 400 mM and prostacyclin, selected from treprostinil and iloprost,, wherein the pH of the external medium is above the pKa of prostacyclin and less than about 7, and, wherein the external medium is substantially free of bicarbonate salt such that there is from less than 2% to 0% bicarbonate salt.