Patent ID: 11951231
Assignee: KINKI UNIVERSITY
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 0:
1. A therapeutic agent for intervertebral disc degeneration, comprising:
Low Adhesive Scaffold Collagen (LASCol) at a concentration of 21 mg/ml or higher, and
a growth factor, wherein the growth factor is a compound selected from the group consisting of Osteogenic Protein-1 (OP-1), bFGF, TGF-β1, GDF-5, BMP2, VEGF, and IGF-1;
wherein the LASCol is in a gel state, wherein the LASCol contains a degradation product of collagen or atelocollagen in which a chemical bond between Y1 and Y2 of an al chain is cleaved in an amino-terminal amino acid sequence including a triple helical domain of the collagen or atelocollagen, the sequence being shown by the following (A), or a chemical bond between G and X3 of an α2 chain is cleaved in an amino-terminal amino acid sequence including a triple helical domain of the collagen or atelocollagen, the sequence being shown by the following (B),, (SEQ ID NO: 1)

(A)-Y1-Y2-Y3-G-Y4-Y5-G-Y6-Y7-G-Y8-Y9-G-, (where G represents glycine, and Y1 to Y9 each represents an amino acid),, (SEQ ID NO: 2)

(B)-G-X1-X2-G-X3-X4-G-X5-X6-G-, (where G represents glycine, and X1 to X6 each represents an amino acid).