Patent ID: 11957767
Assignee: YANTAI LANNACHENG BIOTECHNOLOGY CO., LTD.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C  Y | IPC A  C

Claim 1:
2. A method for preparing a compound targeting prostate specific membrane antigen, comprising the following steps:
introducing a Boc protective group to one end of 4,4′-diamino-3,3′-dimethyl biphenyl, followed by a reaction with 4,6-diamino-5-hydroxy-1,3-naphthalenedisulfonic acid to prepare a truncated Evans Blue derivative; removing the Boc protective group, followed by an amide condensation reaction with Nα-Fmoc-Np-Boc-L-lysine; next, removing the Boc protective group under the action of TFA, followed by an amide condensation reaction with COOH-PEG2-COOH and a reaction with PSMA-617 under the presence of EDC and NHS; then removing an Fmoc protective group using piperazine; and finally, carrying out a reaction with DOTA-NHS to obtain a compound having the following structure shown in Formula (II-1):,