Patent ID: 11939320
Assignee: ABBVIE INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 18:
19. The compound of claim 1, wherein the compound of Formula (I) is a compound of Formula (I-a):, , or a pharmaceutically acceptable salt thereof, wherein:
D is cyclobutyl optionally substituted with 1-4 RX groups;
L1 is selected from the group consisting of a bond, —CH2O—*, —CH2OCH2—*, —NCH3—, —NH—, and —O—, wherein “—*” indicates the attachment point to A;
R1 is selected from the group consisting of hydrogen and —CH3;
L2 is selected from the group consisting of a bond and —CH2—*, wherein “—*” indicates the attachment point to Z;
R2 is selected from the group consisting of hydrogen and —CH3; or
L2 and R2, together with the nitrogen to which they are attached, form an azetidine, pyrrolidine, piperidine, 2-azaspiro[3.3]heptane, piperazine, piperazinone, or 2,6-diazaspiro[3.3]heptane moiety, each of which is optionally substituted with 1-4 RW groups; or
one RY, R2, and L2, together with the nitrogen to which R2 and L2 are attached, form a 4-9 membered monocyclic heterocycle, wherein Z is fused to the formed 4-9 membered monocyclic heterocycle, wherein the available carbon atoms of Z are optionally substituted with 1-4 RY; and wherein if Z contains a substitutable nitrogen moiety, the substitutable nitrogen may be optionally substituted with RN3;
A is phenyl or pyridyl, each of which is optionally substituted with 1-5 RY groups;
Z is phenyl, pyridyl, oxazolyl, isoxazolyl, imidazolyl, pyrimidinyl, or pyrazolyl, each of which is optionally substituted on one or more available carbons with 1-5 RY groups; and wherein pyrazolyl may be optionally substituted on an available nitrogen with hydrogen or —CH3;
each RW is independently fluoro, chloro, oxo, —OH, —OCH3, —CF3, —CH3, —CH2CH3, or —CH(CH3)2;
each RX is independently fluoro, oxo, —OH, O—CH3, —C(O)OH, or —C(O)OCH3;
each RY is independently chloro, fluoro, —CHF2, —CF3, —CH3, —CH2CH3, —CH(CH3)2, —OCH3, —OCHF2, —OCF3, —OCH2CF3, —OCH(CH3)2, or —CN; or
2 RY groups on adjacent atoms, together with the atoms to which they are attached form a furanyl, pyrrolyl, pyridyl, phenyl, or dioxolanyl ring, each of which is optionally substituted with 1-2 RX.