Patent ID: 11959133
Assignee: UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION
Field: Measurement (Instruments)
Classification: CPC C  G | IPC C  G

Claim 0:
1. A nanopore system for sequencing an unknown polymer, the system comprising:
(a) a nanopore positioned in a nonconductive barrier between a first conductive liquid medium and a second conductive liquid medium that are in liquid communication through the nanopore;
(b) a voltage source configured to apply a voltage across the nonconductive barrier;
(c) a data acquisition device configured to detect an ion current through the nanopore; and
(d) one or more unknown polymers operative to pass through the nanopore of the nanopore system from the first conductive liquid medium to the second conductive liquid medium to generate an ion current level pattern; and
(e) a reference map comprising ion current level signals generated from polymer subunit combinations of a 4 or more-mer sequence; and
wherein comparing the ion current level in the unknown polymer to the reference map provides polymer sequence information.