Patent ID: 11899023
Assignee: REGENERON PHARMACEUTICALS, INC.
Field: Measurement (Instruments)
Classification: CPC G | IPC G

Claim 5:
6. A method for identifying at least one dimer species, said method comprising:
contacting a sample including the dimer species to a chromatographic system having a size-exclusion chromatography resin;
washing said size-exclusion chromatography resin using a mobile phase to provide an eluent including the dimer species;
identifying the dimer species in said eluent using an electrospray ionization mass spectrometer under native conditions; and
wherein the eluent provided from washing the size-exclusion chromatography resin is introduced in the electrospray ionization mass spectrometer, wherein a spray voltage of electrospray is about 0.8 kV to about 1.5 kV.