Patent ID: 11903908
Assignee: ADAMAS PHARMA, LLC
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 0:
1. A method of reducing OFF time in a patient with Parkinson's disease (PD), wherein the patient is being treated with a levodopa and is experiencing OFF periods, the method comprising:
(1) orally administering to said patient once daily for at least one week a first composition comprising 85 mg to 170 mg of a pharmaceutically acceptable salt of amantadine, and at least one excipient that modifies the release of at least a portion of the amantadine or pharmaceutically acceptable salt thereof to provide an extended release form; and thereafter
(2) orally administering to said patient once daily a second composition comprising about 300 mg to 380 mg of a pharmaceutically acceptable salt of amantadine, and at least one excipient that modifies the release of at least a portion of the amantadine or pharmaceutically acceptable salt thereof to provide an extended release form;
wherein OFF time in the patient is reduced after at least 7 weeks of administering the second composition once daily to the patient; and
wherein the plasma concentration of amantadine in the patient is increased less than 10% at 1 hour after administration of the second composition.