Patent ID: 11970495
Assignee: KIND PHARMACEUTICAL
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 0:
1. A compound of Formula I,, or an isotopically labeled compound thereof, or an optical isomer thereof, a geometric isomer thereof, a tautomer thereof or a mixture of various isomers, or a pharmaceutically acceptable salt thereof, or a prodrug thereof, in which
R2 and R2 are each independently selected from the group consisting of cyano, alkyl, heterocyclyl, alkenyl, alkynyl, aryl, heteroaryl, acyl, amino, R9O—, R9S—, R9(O═)S—, and R9(O=)2S—, wherein R9 is alkyl, heterocyclyl, alkenyl, alkynyl, aryl or heteroaryl; and
wherein the alkyl, heterocyclyl, alkenyl, alkynyl, aryl, heteroaryl, acyl, and amino are optionally substituted by one or more substituents wherein the substituents are independently selected from the group consisting of halo, cyano, hydroxy, amino, carboxy, acyl, alkyl, heterocyclyl, alkenyl, alkynyl, aryl, heteroaryl, ═O, ═S, —SH, R10O—, R10S—, R10(O═)S—, and R10(O=)2S—, and wherein R10 is alkyl, heterocyclyl, alkenyl, alkynyl, aryl, or heteroaryl; or R1 and R2 are taken together to form a ring;
R6 and R6′ are each independently selected from the group consisting of hydrogen and optionally substituted alkyl; and
R8 is selected from the group consisting of hydrogen, alkyl and —OC(O)R14, wherein R14 is alkyl, heterocyclyl, alkenyl, alkynyl, aryl or heteroaryl; wherein the alkyl, heterocyclyl, alkenyl, alkynyl, aryl, or heteroaryl group is optionally substituted with the following groups: halogen, cyano, hydroxy, amino, carboxy, acyl, alkyl, heterocyclyl, alkenyl, alkynyl, aryl, heteroaryl, ═O, ═S, —SH, R15O—, R15S—, R15(O═)S—, and/or R15(O=)2S—;
wherein R15 is alkyl, heterocyclyl, alkenyl, alkynyl, aryl, or heteroaryl.