Patent ID: 11932683
Assignee: NEW YORK UNIVERSITY
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A  G | IPC A  C

Claim 13:
14. A variant Leukocidin E (LukE) protein or polypeptide thereof of SEQ ID NO:4, said variant LukE protein or polypeptide comprising the amino acid sequence of residues 57-75 and 139-150 of SEQ ID NO: 4, and comprising one or more changes to the amino acid sequence of any of (i) residues 164-178 of SEQ ID NO: 4, (ii) residues 182-196 of SEQ ID NO: 4, or (iii) residues 237-271 of SEQ ID NO: 4, wherein the one or more changes to the amino acid sequence of residues 182-196 of SEQ ID NO: 4, when present, includes a change to at least one of Pro184, Glyl86, Pro187, and Glyl89.