Patent ID: 11931414
Assignee: SEAGEN INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 1:
2. The Ligand Drug Conjugate compound of claim 1, wherein the NAMPT Head (HN) Unit has the structure of:, or a salt thereof, and wherein the quaternized NAMPT (HN+) Unit has the structure of:, or a salt thereof, wherein said optional formal cyclization of DA is to an adjacent carbon atom of the pyridine or pyridinium aromatic ring system of HN or HN+, respectively, through an introduced aromatic oxygen, sulfur or an optionally substituted nitrogen atom so that HN/HN+ contains a 6-5 fused aromatic ring system,
wherein
the pound sign (#) indicates the point of covalent attachment to LO; and
the wavy line indicates the site of covalent attachment to DA and an adjacent aromatic carbon atom thereto is the site of said optional formal cyclization by DA to HN/HN+.