Patent ID: 11858956
Assignee: OREGON HEALTH & SCIENCE UNIVERSITY
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 13:
14. A method for treating a viral infection in a subject having the viral infection, the method comprising administering to the subject a compound having a structure represented by a formula:, wherein R1 is selected from hydrogen, —C(O)R10, —C(O)CH(R11)NH2, —P(O)(OAr1)NHCH(R12)CO2R13, and —P(O)(OR14a)(OR14b);
wherein R10, when present, is selected from C1-C20 alkyl and C2-C20 alkenyl;
wherein RH, when present, is a residue of an amino acid selected from arginine, histidine, lysine, aspartic acid, glutamic acid, serine, threonine, asparagine, glutamine, cysteine, glycine, proline, alanine, valine, isoleucine, leucine, methionine, phenylalanine, tyrosine, and tryptophan;
wherein R12, when present, is selected from C1-C6 alkyl and C3-C6 cycloalkyl;
wherein R13, when present, is selected from C1-C8 alkyl, C3-C8 cycloalkyl, Ar2, and —CH2Ar2;
wherein Ar2, when present, is selected from C6-C14 aryl and C2-C10 heteroaryl, and is substituted with 0, 1, 2, or 3 groups independently selected from halogen, —CN, —NH2, —OH, —NO2, C1-C4 alkyl, C2-C4 alkenyl, C1-C4 haloalkyl, C1-C4 cyanoalkyl, C1-C4 hydroxyalkyl, C1-C4 haloalkoxy, C1-C4 alkoxy, C1-C4 alkylamino, (C1-C4)(C1-C4) dialkylamino, and C1-C4 aminoalkyl;

wherein each of R14a and R14b, when present, is independently C1-C8 alkyl; and
wherein Ar1, when present, is selected from C6-C14 aryl and C2-C10 heteroaryl, and is substituted with 0, 1, 2, or 3 groups independently selected from halogen, —CN, —NH2, —OH, —NO2, C1-C4 alkyl, C2-C4 alkenyl, C1-C4 haloalkyl, C1-C4 cyanoalkyl, C1-C4 hydroxyalkyl, C1-C4 haloalkoxy, C1-C4 alkoxy, C1-C4 alkylamino, (C1-C4)(C1-C4) dialkylamino, and C1-C4 aminoalkyl; and

wherein R2 is a structure represented by a formula selected from:, and
wherein R15, when present, is selected from hydrogen, —C(O)(C1-C20 alkyl), —C(O)(C3-C6 cycloalkyl), and —C(O)(C2-C20 alkenyl),

provided that when R1 is hydrogen, then R2 is, and R15 is —C(O)(C1-C20 alkyl), —C(O)(C3-C6 cycloalkyl), or —C(O)(C2-C20 alkenyl),
or a pharmaceutically acceptable salt thereof.