Patent ID: 11860123
Assignee: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
Field: Measurement (Instruments)
Classification: CPC G  C  B | IPC B  C  G

Claim 14:
15. An apparatus comprising:
a database comprising a plurality of reference signals, each of the plurality of reference signals corresponding to one of methyl-CpG binding domain (MBD-1) protein, methyl CpG binding protein 2 (MeCP2), or γcyclodextrin (GCD);
a membrane, wherein the membrane has a first side and a second side, wherein the membrane has a pore disposed therein, wherein the pore extends through the membrane from the first side of the membrane to the second side of the membrane;
a processing system including a processor; and
a memory that stores executable instructions that, when executed by the processing system, facilitate performance of operations, the operations comprising:
electronic sensing of an electrical characteristic associated with a translocation of a test DNA through the pore, wherein the translocation is movement of part of the test DNA through the pore, wherein a feature of the test DNA comprises an epigenetic biomarker, and wherein the electronic sensing is performed by an electric current along the membrane that results in a sensed electrical characteristic;
comparing the sensed electrical characteristic each of the plurality of reference signals, and wherein the comparing results in a comparison result; and
determining, based upon the comparison result, with which of the plurality of reference signals the sensed electrical characteristic corresponds, resulting in a corresponding reference signal, wherein the determining comprises determining that at least a first correlation peak between the corresponding reference signal and the sensed electrical characteristic is above a threshold and that at least a second correlation peak between the corresponding reference signal and the sensed electrical characteristic is above the threshold, and wherein the determining comprises determining with which of the plurality of reference signals the sensed electrical characteristic corresponds most closely, relative to each other ones of the plurality of reference signals.