Patent ID: 11866725
Assignee: NOVARTIS AG
Field: Biotechnology (Chemistry)
Classification: CPC C | IPC C

Claim 15:
16. The lentiviral transfer vector of claim 15, wherein one of said one or more primary signaling domains comprises a CD3-zeta stimulatory domain, wherein one or more of said costimulatory signaling domains comprises an intracellular domain selected from a costimulatory protein selected from the group consisting of CD27, CD28, 4-1BB (CD137), OX40, GITR, CD30, CD40, ICOS, BAFFR, HVEM, ICAM-1, lymphocyte function-associated antigen-1 (LFA-1), CD2, CDS, CD7, CD287, LIGHT, NKG2C, NKG2D, SLAMF7, NKp80, NKp30, NKp44, NKp46, CD160, B7-H3, and a ligand that specifically binds with CD83.