Patent ID: 11884655
Assignee: TREVENA, INC.
Field: Organic fine chemistry (Chemistry)
Classification: CPC C | IPC C

Claim 12:
13. The process of claim 12, wherein the method comprises the steps of:
(a) adding pyrrolidine to a solution of a compound of, , in a compound of R2R3C═O to form a mixture;
(b) heating the mixture of step (a) to reflux, stirring the mixture for about 19.5 hours under the temperature, cooling the mixture to about 15-20° C., and adding water to the mixture
(c) adjusting the pH of the mixture of step (b) to about 2 with HCl;
(d) stifling the mixture of step (c) with n-heptane to form a slurry and stifling the slurry at about 15-20° C. for about 1 hour, and filtering the slurry to form a solid; and
(e) washing the solid of step (d) with water and n-heptane; and
(f) drying the solid of step (e) at about 50° C. under vacuum to form the compound of, , wherein the variables are as defined in claim 1.