Patent ID: 11861475
Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
Field: Computer technology (Electrical engineering)
Classification: CPC G | IPC G

Claim 6:
7. The method of claim 6, wherein the SSL model includes incorporating a Proliferation-Invasion (PI)-estimated regional cell density into a graph-based SSL using:, f
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wherein L is a number of biopsy samples in a training dataset, yl is a pathologically measured tumor cell density for the l-th biopsy sample, xl contains features computed from a localized region of multiparametric MRI corresponding to a biopsy location and a tumor density prediction of the mechanistic model, ƒ(xl) is a predictive function for cell density, (yl−ƒ(xl))2 is a loss function that measures a discrepancy between the pathologically measured cell density and a predicted density of each biopsy sample, ƒ is a function on a reproducing kernel Hilbert space (RKHS), K, with a Mercer kernel K, ∥ƒ∥K2 is a norm on K, γA is a tuning parameter, f contains predictive density for each labeled and unlabeled sample, Σi,jwij is a sum of all edge weights in a graph used by the graph-based SSL.