Patent ID: 11965036
Assignee: ZYMEWORKS BC INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A  G | IPC A  C  G

Claim 13:
14. The method of claim 12, where the heterodimeric Fc is a human IgG1 Fc, the first Fc polypeptide is operably linked to the first antigen binding polypeptide construct with an IgG1 hinge region linker, the first CH3 sequence comprises T350V_L351Y_F405A_Y407V modifications in the first Fc polypeptide, the second Fc polypeptide is operably linked to the second antigen binding polypeptide construct with an IgG1 hinge region linker, and the second CH3 sequence comprises T350V_T366L_K392L_T394W modifications according to EU numbering compared to a wild-type homodimeric human IgG1 Fc.