Patent ID: 11865150
Assignee: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C  G | IPC A  C  G

Claim 0:
1. A method for treating cancer in a mammal, wherein said method comprises:
(a) identifying said mammal as having cancer cells that have a virotherapy permissive interferon (IFN)-stimulated gene (ISG) signature, wherein said virotherapy permissive ISG signature comprises a decreased level of expression of at least 6 ISGs selected from the group consisting of HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, IFI27, IFI35, IFI6, IFIT1, IFIT3, IRF1, IRF2, IRF9, ISG15, MX1, MX2, OAS1, OAS2, OAS3, OASL, SOCS1, and STAT2, wherein said virotherapy permissive ISG signature indicates that said cancer cells are responsive to treatment with an oncolytic virus; and
(b) administering said oncolytic virus to said mammal under conditions wherein the number of cancer cells within said mammal is reduced.