Patent ID: 11931415
Assignee: THE UNIVERSITY OF LIVERPOOL
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 0:
1. A liquid ophthalmic tamponade composition comprising:
i) a base oil comprising a silicone oil;
ii) a free drug; and
iii) an additive comprising a first segment that facilitates or modulates solubility in the base oil, conjugated to a second segment that facilitates or modulates solubility and/or release of the free drug, wherein the first segment comprises poly(dimethylsiloxane), the second segment comprises a group that aids solubility of the free drug in the base oil and/or modifies release of the free drug therefrom, wherein the second segment of the additive comprises a hydrophobic moiety comprising a group selected from C1-25 alkyl groups, C2-25 alkenyl groups, C7-25 alkyl-aryl groups, C8-25 alkenyl-aryl groups, C-1-10 alkyl-O-C1-10 alkyl groups, amine groups, amide groups, or ester groups; and
wherein the composition comprises of components that are suitable for application into the vitreous space of an eye.