Patent ID: 11912663
Assignee: SHANGHAI AB PHARMATECH LTD.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A compound represented by formula IIIb, or a stereoisomer, tautomer, deuterate, pharmacologically acceptable salt, or hydrate thereof:, wherein:
E is a nitrogen (N) or CH;
G1 is independently selected from H, deuterium (D), halogen, cyano, C1-20 alkyl, C1-20 alkoxy, or C1-20 alkylamino group;
G2 is independently selected from halogen, cyano, C1-20 alkylamino, C2-20 hydroxyalkylideneamino, C3-20 hydroxycycloalalkylideneamino, C1-20 cyanoalkylideneamino, C4-20 cyanocycloalalkylideneamino, C1-20 aminoalkylideneamino, C3-20 aminocycloalkylideneamino, C1-20 carboxyalkylideneamino, C4-20 carboxycycloalalkylideneamino, 3-6 members heterocyclic-amino group, or —OR6, wherein R6 is independently selected from H, deuterium (D), C1-20 alkyl, C1-20 haloalkyl, C1-20 cyanoalkyl, C4-20 cyanocycloalalkylidene, C2-20 hydroxyalkylidene, C3-20 hydroxycycloalkylidene, C1-20 aminoalkylidene, C3-20 aminocycloalkylidene, C2-20 carboxyalkylidene, C4-20 carboxycycloalalkylidene, C3-6 cycloalkylidene, C3-6 aminocycloalkylidene, C1-20 amino(C3-20cycloalkyl)alkylidene, 3-6 members heterocycloalkyl, or 3-6 members heterocycloalkylidene group.
G3 is independently selected from cyano, —C(O)OR, —C(O)NH2, —C(O)ND2, C1-20 alkoxy, C1-20 alkylamino, or a —C(O)NR4R5 group: wherein R is H, or C1-20 alkyl, R4 and R5 are each independently selected from H, deuterium (D), C1-20 alkyl, C1-20 haloalkyl, C1-20 cyanoalkylidene, C4-20 cyanocycloalalkylidene, C2-20 hydroxyalkylidene, C3-20 hydroxycycloalkylidene, C2-20 aminoalkylidene, C3-20 aminocycloalkylidene, C2-20 carboxyalkylidene, C4-20 carboxycycloalalkylidene, C3-20 cycloalkenyl, C3-20 cycloalkyl, 3-6 members heterocyclic, 3-6 members heterocyclic alkylidene, C6-20 aryl, C3-20 heterocyclic aryl, C1-20 alkyl sulfonyl, C3-20 cycloalkyl sulfonyl, or C2-20 heterocycloalkyl sulfonyl group; or R4 and R5 may be linked each other to form a C2-20 heterocyclic group or a C3-20 heterocyclic aryl group containing 3-8 members of 1-3 heteroatoms; or may be linked each other to form C9-C20 fused alkylaryl or C8-C20 aryl group,
G4 and G5 are each independently selected from H, deuterium (D), halogen, cyano, C1-20 alkyl, C1-20 alkoxy, or C1-20 alkylamino goup;
R1 is each independently selected from H, deuterium (D), C1-20 alkyl, C3-20 cycloalkyl, or C3-20 deuterated cycloalkyl group;
R2 and R3 are each independently selected from H, deuterium (D), C1-20 alkyl, C3-20 cycloalkyl, C3-20 deuterated cycloalkyl, or a 3-6 membered heterocyclic group;
X1, X2 and X3 are each independently selected from halogen, cyano, amino, C1-20 alkoxy, or C1-20 alkyl amino group;
X4 is each independently selected from H, deuterium (D), halogen, cyano, amino, C1-20 alkoxy, or C1-20 alkylamino group.