Patent ID: 11866743
Assignee: TELEDYNE FLIR DETECTION, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 12:
13. The method of claim 3, wherein:
a) the first OPH protein:polymer conjugate comprises an enzymatically active, genetically-modified OPH protein (OPH-YT), conjugated to at least a first polymer, wherein the polymer has a molecular weight in a range of 175 kDa to 222 kDa and comprises a PEGMA chain (OPH-YT-PEGMA);
b) the second OPH protein:polymer conjugate comprises an enzymatically active, genetically-modified OPH protein (OPH-IVH3), conjugated to at least a second polymer, wherein the polymer has a molecular weight in a range of 175 kDa to 222 kDa and comprises a PEGMA chain (OPH-IVH3-PEGMA); and
c) the in vivo kcat/km of each of the first and the second OPH protein:polymer conjugates is one or both of:
i) ≥I×107 for at least one G-series chemical warfare agent; and
ii) ≥I'105 for at least one V-series chemical warfare agent.