Patent ID: 11913026
Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 14:
15. A method for producing of a bispecific cytotoxic lymphocyte or macrophage-redirecting autoantibody, the method comprising:
isolating an endogenous autoantibody from sera of a living subject having a tumor or foreign body;
covalently conjugating the isolated endogenous autoantibody to a cytotoxic lymphocyte or macrophage targeting domain, wherein the cytotoxic lymphocyte or macrophage targeting domain is fused to a photoreactive antibody-binding domain (pAbBD), and the pAbBD contains a photoreactive crosslinker, that upon irradiating with long wavelength UV light covalently links the pAbBD and the cytotoxic lymphocyte or macrophage targeting domain to the isolated endogenous autoantibody, thereby producing the bispecific cytotoxic lymphocyte or macrophage-redirecting autoantibody.