Patent ID: 11946066
Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
Field: Biotechnology (Chemistry)
Classification: CPC C | IPC C

Claim 18:
19. A system for delivering a polynucleotide to a target cell of a subject in need thereof, comprising: a viral vector of claim 1 or a sender cell capable of releasing a viral vector of claim 1; and a first bridge protein comprising a glycoprotein binding domain and a first antigen-binding moiety, wherein the glycoprotein binding domain is capable of binding the glycoprotein, wherein the first antigen-binding moiety is capable of binding a first antigen on a surface of a target cell, and wherein the viral vector is capable of transducing the target cell when the first antigen-binding moiety is bound to the first antigen and the glycoprotein binding domain is bound to the glycoprotein, or wherein the sender cell is capable of releasing the first bridge protein.