Patent ID: 11891621
Assignee: KEIO UNIVERSITY
Field: Biotechnology (Chemistry)
Classification: CPC C | IPC C

Claim 0:
1. A method of differentiating a pluripotent stem cell into a hepatoblast and/or a liver cell, including a step of introducing a transcription factor including any one of the following (1) to (5) into a pluripotent stem cell of mammalian origin:
(1) one transcription factor selected from TGIF, TCF4, PITX2, and MEIS1;
(2) two transcription factors selected from TGIF, TCF4, PITX2, SALL4, and MEIS1;
(3) three transcription factors selected from TGIF, TCF4, PITX2, SALL4, and MEIS1;
(4) four transcription factors selected from TGIF, TCF4, PITX2, SALL4, and MEIS1 and
(5) five transcription factors selected from TGIF, TCF4, PITX2, SALL4, and MEIS1.