Patent ID: 11858877
Assignee: UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 9:
10. A method of preventing formation of mature TNFR1 complex, comprising contacting a cell with a compound of formula (I):, , or a salt or hydrate thereof, wherein:
A is an azinic acid;
B is an alkyl sulfonyl;
X1 and X3 are independently selected from O, NOH, NO-alkyl, CF3, and C(CN)2;
X2 is selected from O, NH, and NF;
R1 is H or alkyl and R2 is an optionally substituted alkyl or cycloalkyl, or R1 and R2 together form an optionally substituted 5- or 6-membered heterocycle.