Patent ID: 11932683
Assignee: NEW YORK UNIVERSITY
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A  G | IPC A  C

Claim 0:
1. A method of treating Staphylococcus aureus infection and/or a condition resulting from a S. aureus infection in a subject comprising:
selecting a subject having or at risk of having S. aureus infection; and
administering to the selected subject a composition comprising a variant of Leukocidin E (LukE) protein or polypeptide of SEQ ID NO:4, said variant LukE protein or polypeptide comprising the amino acid sequence of residues 57-75 and 139-150 of SEQ ID NO: 4, and comprising one or more changes to the amino acid sequence of any of (i) residues 164-178 of SEQ ID NO: 4, (ii) residues 182-196 of SEQ ID NO: 4, or (iii) residues 237-271 of SEQ ID NO: 4,
wherein the one or more changes to the amino acid sequence of residues 182-196 of SEQ ID NO: 4, when present, includes a change to at least one of Pro184, Glyl86, Pro187, and Glyl89; and
wherein said administering is carried out under conditions effective to treat S. aureus infection and/or a condition resulting from a S. aureus infection in the subject.