Patent ID: 11857289
Assignee: WASHINGTON UNIVERSITY
Field: Medical technology (Instruments)
Classification: CPC A  G | IPC A  G

Claim 0:
1. A system for generating optimized functional images of a lesion region of a breast, the system comprising:
a diffuse optical tomography (DOT) device configured to acquire lesion functional data from the lesion region of the breast and to acquire reference functional data from a healthy tissue region of a contralateral breast;
a computing device in communication with the DOT device programmed to:
transform the lesion functional data and the reference functional data to produce perturbation data, the perturbation data comprising a normalized difference between the lesion functional data and the reference functional data;
generate a preliminary estimate of functional images by applying a truncated pseudoinverse matrix of a weight matrix to the perturbation data, the weight matrix comprising a plurality of elements representing system measurement sensitivity of the breast and distribution of diffused optical waves in a homogenous medium;
generate the optimized functional images by iteratively optimizing successive estimates of the functional images regularized by the preliminary estimate of the functional images weighted by a regularization parameter, wherein a value of the optimized functional images at each voxel in the lesion region is indicative of a hemoglobin concentration at that voxel; and
display the optimized functional images.