Patent ID: 11931389
Assignee: ZHEJIANG SHOUXIANGU PHARMACEUTICAL COMPANY, LTD.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 0:
1. A method for preparing a tablet of sporoderm-removed Ganoderma lucidum spore powder, comprising the following steps:
1) mixing 13-20 parts by weight of a water extract of sporoderm-disrupted Ganoderma lucidum spore powder, 3-5 parts by weight of sorbitol and 0.8-1.2 parts by weight of povidone K30 for 10-30 min, and subjecting the obtained mixture to granulating, screening and drying to obtain a granular material; and
2) tableting the granular material obtained in step 1) to obtain the tablet of sporoderm-removed Ganoderma lucidum spore powder, wherein the water extract of sporoderm-disrupted Ganoderma lucidum spore powder is obtained by conducting water extraction, concentration, drying and pulverization on the sporoderm-disrupted Ganoderma lucidum spore powder;
wherein the water extraction is a three-stage water extraction, wherein a temperature fora first-stage water extraction is 25-30° C., time for the first-stage water extraction is 1-3 h, and a mass of water used for the first-stage water extraction is 10-15 times larger than that of the sporoderm-disrupted Ganoderma lucidum spore powder; and temperatures for a second-stage water extraction and a third-stage water extraction are independently 95-100° C., time for the second-stage water extraction and the third-stage water extraction is independently 1-3 h, and masses of water used for the second-stage water extraction and the third-stage water extraction are independently 8-12 times larger than that of the sporoderm-disrupted Ganoderma lucidum spore powder; and
wherein the water extract contains 2-10 g/100 g of total polysaccharides and 1.2-5 g/100 g of total triterpenes, and contains no sporoderm residues;
wherein an amount of the water extract of sporoderm-disrupted Ganoderma lucidum spore powder, sorbitol and povidone K30 is controlled such that in the tablet of sporoderm-removed Ganoderma lucidum spore powder, a mass fraction of total polysaccharides is 1.5-7.6%, and a mass fraction of total triterpenes is 0.9-4%.