Patent ID: 11896672
Assignee: ARBUTUS BIOPHARMA CORPORATION
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 0:
1. The compound:, or a salt thereof, wherein Q is -L1-R1;
L1 is a divalent, branched or unbranched, saturated or unsaturated, hydrocarbon chain, having from 1 to 14 carbon atoms, wherein one or more of the carbon atoms in the hydrocarbon chain is optionally replaced with —NRX—C(═O)—, or —C(═O)—NRX—, and wherein RX is hydrogen or (C1-C6)alkyl, and wherein the hydrocarbon chain, is optionally substituted with oxo(═O); or
L1 is selected from the group consisting of:, R1 has the following formula:, , wherein:
B1 is CH;
B2 is selected from the group consisting of:, B3 is selected from the group consisting of:, T1 is a branched or unbranched, saturated or unsaturated, hydrocarbon chain, having from 1 to 20 carbon atoms, wherein one or more of the carbon atoms in the hydrocarbon chain is optionally replaced by —NRX—C(═O)—, or —C(═O)—NRX—, and wherein RX is hydrogen or (C1-C6)alkyl, and wherein the hydrocarbon chain, is optionally substituted with oxo (═O), that is covalently bonded to B1;
T2 is a branched or unbranched, saturated or unsaturated, hydrocarbon chain, having from 1 to 20 carbon atoms, wherein one or more of the carbon atoms in the hydrocarbon chain is optionally replaced by —NRX—C(═O)—, or —C(═O)—NRX—, and wherein RX is hydrogen or (C1-C6)alkyl, and wherein the hydrocarbon chain, is optionally substituted with oxo (═O), that is covalently bonded to B1;
each of T3, T4, T5, and T6 is independently selected from the group consisting of:, n=1, 2, or 3;
each saccharide is independently selected from the group consisting of:, R2 is a siRNA substituent; and
R′ is C1-9 alkyl, C2-9 alkenyl or C2-9 alkynyl; wherein the C1-9 alkyl, C2-9 alkenyl or C2-9 alkynyl are optionally substituted with halo or hydroxyl.