Patent ID: 11865187
Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 0:
1. A composition comprising at least one recombinant adeno-associated virus (rAAV) and at least one pharmaceutically acceptable carrier, preservative, and/or stabilizer, wherein the at least one rAAV comprises a vector genome in an AAV capsid,
wherein the vector genome is a nucleic acid molecule which comprises an AAV 5′ ITR, an expression cassette, and an AAV 3′ ITR,
wherein said expression cassette comprises:
(i) a coding sequence for an anti-Her2 immunoglobulin heavy chain having an IL-2 leader peptide, a heavy chain variable region having an amino acid sequence of SEQ ID NO: 18 and a heavy chain constant region,
(ii) a linker sequence,
(iii) a coding sequence for an anti-Her2 immunoglobulin light chain having an IL-2 leader peptide, a light chain variable region having an amino acid sequence of SEQ ID NO: 20, and a light chain constant region, and
(iv) regulatory sequences which direct expression of the heavy chain and the light chain, and
wherein following expression in the cell, a anti-Her2 heavy chain and the anti-Her2 light chain form an anti-Her2 antibody in vivo.