Patent ID: 11918785
Assignee: REGENERON PHARMACEUTICALS, INC.
Field: Medical technology (Instruments)
Classification: CPC A  B | IPC A  B

Claim 13:
14. A method of preparing a drug product in a packaging component, comprising:
determining a theoretical fill volume, wherein the theoretical fill volume is a sum of a theoretical lost volume and a theoretical administered drug volume;
determining a drug height based on the theoretical fill volume and dimensions of the packaging component;
introducing a volume of a formulated drug substance into the packaging component comprising a body, wherein the volume of the formulated drug substance corresponds to the theoretical fill volume and is greater than a nominal volume of the packaging component; and
stoppering the packaging component at a stopper position that is distal from a proximal end of the packaging component,
wherein the stoppering includes determining a stopper position within the packaging component, wherein determining the stopper position includes determining a distance from the proximal end of the packaging component that restricts a plunger rod, connected to the stopper, from tilting to deform the stopper to an extent that comprises a seal formed by the stopper.