Patent ID: 11952363
Assignee: HOFFMANN-LA ROCHE, INC.
Field: Organic fine chemistry (Chemistry)
Classification: CPC C  A | IPC C

Claim 5:
6. A process for the preparation of a compound of formula (I) according to claim 1 comprising any of the following steps:
a) coupling reaction of a compound of formula (VI),, and an amine HR3b in the presence of a coupling reagent and a base;
b) carrying out a Buchwald-Hartwig amination reaction of a compound of formula (X),, and an amine HR6 in the presence of a catalyst and a base;
wherein:
in step a),
the coupling reagent, is HATU; and
the base, is DIPEA;

in step b),
the catalyst, is Ruphos Pd-G2;
the, is Cs2CO3;
X is halogen, OTf, or OMs;
Y is N or CH; R6 is piperazine.