Patent ID: 11896619
Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 47:
48. The CAR polypeptide of claim 44, wherein the intracellular domain comprises a CD3-zeta signaling domain comprising the amino acid sequence of SEQ ID NO: 27, and a 4-1BB costimulatory domain comprising the amino acid sequence of SEQ ID NO: 26; wherein the CAR polypeptide comprises a CD8 transmembrane domain and a CD8 hinge region, wherein the CD8 transmembrane domain and the CD8 hinge region comprise the amino acid sequence of SEQ ID NO: 25; and wherein the CAR polypeptide further comprises a leading sequence comprising the amino acid sequence set forth in SEQ ID NO: 23.