Patent ID: 11957703
Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 2:
3. A method for recovering from, treating, or preventing radiation damage or radiation exposure, recovering from, treating, or preventing chemotherapy-induced damage or cellular senescence, modulating DNA repair, or modulating cell proliferation or cell survival in a subject in need thereof comprising
i) assessing protein-protein complexes in a sample from said subject, wherein said protein-protein complexes are between a first protein containing a Nudix Homology Domain (NHD) and a second protein which is different from the first protein and interacts with the NHD;
ii) administering to the subject an effective amount of
a) nicotinamide mononucleotide (NMN), or an analog or derivative thereof; or
b) an agent that is not NMN or an analog or derivative thereof, wherein the agent increases the level of nicotinamide mononucleotide, or an analog or derivative thereof; or
c) both a) and b); or
d) an NHD-modulating agent that is not a) or b), wherein said NHD-modulating agent modulates protein-protein complex forming activity of the Nudix Homology Domain of said first protein in step (i).