Patent ID: 11930837
Assignee: NOVARTIS AG
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C  B | IPC A  B  C

Claim 0:
1. A method of expanding Treg cells in a patient in need thereof, comprising administering an antibody cytokine engrafted protein comprising:
(a) a heavy chain variable region (VH) that comprises a HCDR1 of SEQ ID NO: 17, a HCDR2 of SEQ ID NO: 18, a HCDR3 of SEQ ID NO: 19; and
(b) light chain variable region (VL) that comprises a LCDR1 of SEQ ID NO: 30, a LCDR2 of SEQ ID NO: 31, and a LCDR3 of SEQ ID NO: 32; and
wherein the HDCR1 comprises an Interleukin 2 (IL2) molecule.