Patent ID: 11859003
Assignee: ADAGENE, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 0:
1. A method for treating a cancer in a subject in need thereof, comprising administering to said subject a therapeutically effective amount of an antibody, or antigen-binding fragment thereof, that binds to an extracellular domain of human CD137, wherein the antibody or antigen-binding fragment comprises a heavy chain variable region and a light chain variable region,
wherein:
(i) the heavy chain variable region comprises an HVR-H1 comprising the amino acid sequence of SEQ ID NO:731, an HVR-H2 comprising the amino acid sequence of SEQ ID NO:755, and an HVR-H3 comprising the amino acid sequence of SEQ ID NO:779; and
(ii) the light chain variable region comprises an HVR-L1 comprising the amino acid sequence of SEQ ID NO:803, an HVR-L2 comprising the amino acid sequence of SEQ ID NO:827, and an HVR-L3 comprising the amino acid sequence of SEQ ID NO:851.