Patent ID: 11951175
Assignee: SYNAFFIX B.V.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C  Y | IPC A  C

Claim 8:
9. The method according to claim 1, wherein the reaction between reactive group Q1 and functional group F1 is a conjugation reaction selected from thiol-alkene conjugation to form a connecting moiety Z3 that may be represented as (10a) or (10b), amino-(activated) carboxylic acid conjugation to form a connecting moiety Z3 that may be represented as (10c), ketone-hydrazino conjugation to form a connecting moiety Z3 that may be represented as (10d) wherein Y═NH, ketone-oxyamino conjugation to form a connecting moiety Z3 that may be represented as (10d) wherein Y═O, alkyne-azide conjugation to form a connecting moiety Z3 that may be represented as (10e) or (10g) and alkene-1,2,4,5-tetrazine conjugation or alkyne-1,2,4,5-tetrazine conjugation to form a connecting moiety Z3 that may be represented as (10h) from which N2 eliminates, wherein moieties (10a), (10b), (10c), (10d), (10e), (10g) and (10h) are represented by:, wherein Z is selected from hydrogen, methyl and pyridyl.