Patent ID: 11958818
Assignee: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Field: Organic fine chemistry (Chemistry)
Classification: CPC C | IPC C

Claim 0:
1. A process for making Compound 1:, the process comprising:
(i) contacting an admixture comprising methylallyl alcohol, (+)-di-isopropyl L-tartrate (L-DIPT) and a solvent/diluent with molecular sieves to provide a first anhydrous admixture;
(ii) cooling the first anhydrous admixture;
(iii) adding Ti(O-iPr)4 to the cooled anhydrous admixture in step (ii) to provide a second anhydrous admixture;
(iv) adding cumene hydroperoxide to the second anhydrous admixture of step (iii) to provide a first reaction mixture;
(v) allowing the contents of the first reaction mixture to react to provide an admixture comprising INT-1;, (vi) filtering the admixture obtained from step (v) to provide a filtrate comprising INT-1;
(vii) optionally treating the filtrate obtained from step (vi) with trimethylphosphite to quench unreacted cumene hydroperoxide (“the quenched filtrate”); and
(viii) treating the filtrate from step (vi) or the optionally quenched filtrate of step (vii) with triethylamine (Et3N), 4-dimethylaminopyridine (DMAP), and 4-bromobenzene-1-sulfonyl chloride (BrsCl) to provide a second reaction mixture; and
(ix) allowing the contents of the second reaction mixture to react to provide an admixture comprising Compound 1.