Patent ID: 11931161
Assignee: ABBOTT LABORATORIES
Field: Measurement (Instruments)
Classification: CPC A  G  C | IPC A  C  G

Claim 0:
1. A method comprising:
a) performing at least one assay for cardiac troponin I (cTnI) and an early biomarker in at least one sample that is whole blood, serum, plasma, or cerebrospinal fluid, obtained from a subject within about 24 hours after an actual or suspected injury to the head, wherein the early biomarker comprises ubiquitin carboxy-terminal hydrolase L1 (UCH-L1), glial fibrillary acidic protein (GFAP), or a combination thereof; and
b) treating the subject for (1) a moderate, severe, or moderate to severe traumatic brain injury (TBI) when the level of cTnI in the sample is higher than a reference level of cTnI and the level of the early biomarker in the sample is higher than a reference level of the early biomarker, or (2) a mild TBI when the level of cTnI in the sample is lower than a reference level of cTnI and/or the level of the early biomarker in the sample is lower than a reference level of the early biomarker,
wherein a subject with (1) a moderate, severe, or moderate to severe TBI is treated (i) with one or more therapeutic agents selected from the group consisting of a diuretic, an anti-convulsant medication and a medication to sedate an individual or induce a coma, or any combination thereof; (ii) with one or more surgical procedures selected from the group consisting of removal of a hematoma, repairing a skull fracture, and a decompressive craniectomy, or any combinations thereof; (iii) with one or more therapies selected from the group consisting of physical therapy for TBI and occupational therapy for TBI, and any combinations thereof; or (iv) with any combination of (i)-(iii); or (2) a mild TBI is treated (i′) with rest; (ii′) by abstaining from physical activities; (iii′) by avoiding light; (iv′) by wearing protective eyewear when in light; (v′) with one or more therapeutic agents selected from the group consisting of a medication for relief of a headache or migraine, and an anti-nausea medication or combinations thereof; or (vi′) with any combination of (i′)-(v′).