Patent ID: 11883503
Assignee: DINGFU BIOTARGET CO., LTD.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A

Claim 0:
1. A composition comprising an immunoconjugate and a cytotoxic agent, wherein:
said immunoconjugate comprises a first member and a second member different from said first member, wherein said first member comprises a first Fc subunit, and said second member comprises two interleukins fused to a second Fc subunit, and said first Fc subunit associates with said second Fc subunit to form a heterodimer;
said two interleukins are fused to an amino-terminal amino acid of said second Fc subunit; wherein said two interleukins are two copies of IL10;
wherein the amino acid sequence of a light chain comprised in the first member is SEQ ID NO: 37, and the amino acid sequence of a heavy chain comprised in the first member is SEQ ID NO: 39;
wherein said cytotoxic agent comprises a radiation agent that emits X-ray radiation and/or electron beam radiation, said cytotoxic therapy comprises at least one dose of a radiation therapy at a dosage of Gy,
or,
wherein said cytotoxic agent is capable of inducing immunogenic cell death comprising oxaliplatin.