Patent ID: 11958830
Assignee: WESTLAKE PHARMACEUTICALS (HANGZHOU) CO., LTD.
Field: Organic fine chemistry (Chemistry)
Classification: CPC C  A | IPC C

Claim 6:
7. A compound of the following structural formula IIIb-2:, , a tautomer thereof, a deuterated derivative of the compound or the tautomer, or a pharmaceutically acceptable salt of the foregoing; wherein:
X is absent, and Z is —NH—, —[CH(CH(CH3)2)]NH—, —C(═O)NHCH[(CONHCH3)]CH2—, or —CH(C2H5)CH2NH—; or
X is —NH—, or —NHCH2—, and Z is absent, —NH—, —[CH(CH(CH3)2)]NH—, —C(═O)NHCH[(CONHCH3)]CH2—, or —CH(C2H5)CH2NH—;
Y is 3- to 10-membered heterocyclyl containing at least one N atom and optionally at least one other heteroatom selected from O and S;
at least one of T and U is N; and
R1 and R2, for each occurrence, are each independently selected from halogen, cyano, C1-C6 alkyl, C2-C6 alkenyl, C1-C6 alkoxy, —C(═O)(C1-C6 alkyl), —C(═O)NRpRq, —NRpRq, —NRpC(═O)Rs, —NRpC(═O)Rs, —NRpC(═O)NRqRr, —NRpS(═O)wRs, —NO2, —ORs, —OC(═O)Rs, —OC(═O)ORs, —OC(═O)NRpRq, —S(═O)wRs, —S(═O)wNRpRq, and —SO3−;
R3, for each occurrence, is each independently selected from halogen, cyano, C1-C6 alkyl, C2-C6 alkenyl, C1-C6 alkoxy, —C(═O)(C1-C6 alkyl), —C(═O)NRpRq, —NRpRq, —NRpC(═O)Rs, —NRpC(═O)ORs, —NRpC(═O)NRqRr, —NRpS(═O)wRs, —NO2, —ORs, —OC(═O)Rs, —OC(═O)ORs, —OC(═O)NRpRq, —S(═O)wRs, —S(═O)wNRpRq, —SO3 and phenyl; wherein:
the C1-C6 alkyl, the C2-C6 alkenyl, and the C1-C6 alkoxy of any one of R1, R2, and R3, and the C1-C6 alkyl of —C(═O)(C1-C6 alkyl) are each optionally substituted with 1 to 3 groups selected from halogen, cyano, —C(═O)Rs, —C(═O)ORs, —C(═O)NRpRq, —NRpRq, —NRpC(═O)Rs, —NRpC(═O)ORs, —NRpC(═O)NRqRr, —NRpS(═O)wRs, —ORs, —OC(═O)Rs, —OC(═O)ORs, —OC(═O)NRpRq, —S(═O)wRs, —S(═O)wNRpRq, C3-C6cycloalkyl, and phenyl that is optionally substituted with 1 to 3 halogen atoms;
the phenyl of R3 is each optionally substituted with 1 to 3 groups selected from halogen, cyano, and —OH;
Rp, Rq, and Rr, for each occurrence, are each independently selected from hydrogen, C1-C4 alkyl, and C3-C6 cycloalkyl; wherein:
the C1-C4 alkyl of any one of Rp, Rq, and Rrr is optionally substituted with 1 to 3 groups selected from halogen, cyano, and —OH;
Rs, for each occurrence, is each independently selected from hydrogen, C1-C4 alkyl, and C3-C6 cycloalkyl;

w is an integer selected from 1 and 2; and
R1, for each occurrence, may be attached to any of the ring atoms of the isoquinoline in formula IIIb-2, as long as valency permits;

m is an integer selected from 0, 1, 2, 3, 4, 5, and 6;
n is an integer selected from 1, 2, 3, and 4; and
is an integer selected from 0, 1, and 2.