Patent ID: 11878061
Assignee: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 0:
1. A method for increasing the in vivo therapeutic index of a chemotherapeutic drug targeting aberrant mammalian cells, which method comprises:
a) combining a therapeutically effective amount of said drug with a biocompatible protein carrier;
b) forming a complex with said carrier and an effective amount of binding agent having specificity to said aberrant cells, wherein said binding agent populates the surface of said complex and retains specificity and further wherein said binding agent has a carrier protein-binding portion, and wherein said binding agent is hydrophobically bound to said complex; and
c) administering said complex to a patient, wherein said administration enhances delivery of said drug to said cells and reduces one or more side effects of said drug, thereby increasing the therapeutic index of said drug.