Patent ID: 11904069
Assignee: UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
Field: Medical technology (Instruments)
Classification: CPC A  C | IPC A

Claim 0:
1. A biomimetic, biodegradable scaffold, comprising:
a polymer/demineralized bone matrix composite, the composite comprising:
polymer fibers selected from the group consisting of nanofibers, microfibers, and combinations thereof, comprising poly(lactic-co-glycolic acid); and
an extracellular demineralized bone matrix derived from a precursor solution comprising demineralized bone matrix suspended in hyaluronic acid, applied to the polymer fibers; and

a mesh substrate comprising an etched magnesium alloy foil, embedded in the composite or encapsulated by the composite and effective to release Mg ions to stimulate bone regeneration,
wherein the composite is a porous and an interconnected fiber structure,
wherein the scaffold stimulates bone tissue regeneration for calvarial critical sized defects, absent of an exogenous growth factor, and
wherein the scaffold has a flexural modulus of greater than 500 MPa to at least 560 MPa.