Patent ID: 11873304
Assignee: INCYTE CORPORATION
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 33:
34. The method of claim 2, wherein:
R1 is H;
R2 is selected from H, CN, and hydroxymethyl;
R4 is selected from —C(O)NR5R6 and -L-Cy4;
R5 is H;
R6 is C1-3 alkyl;
L is selected from Y1, C1-3 alkylene, C1-3 alkylene-Y1, and Y1—C1-3 alkylene, wherein said alkylene linking groups are each optionally substituted with 1, 2, or 3 independently selected R8D substituents and optionally substituted with 1 Rg substituent;
each Y1 is —NRY—;
RY is selected from H and C1-3 alkyl;
Cy4 is selected from phenyl, cyclohexyl, pyridyl, pyrrolidinonyl, and imidazolyl, wherein the phenyl, cyclohexyl, pyridyl, pyrrolidinonyl, and imidazolyl are each optionally substituted with 1, 2, 3, 4, or 5 substituents independently selected from R8D and R8;
each R8 is independently selected from halo, C1-3 alkyl, C1-3 haloalkyl, C2-4 alkenyl, C2-4 alkynyl, phenyl, C3-7 cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C1-4 alkyl, C3-7 cycloalkyl-C1-4 alkyl, (5-6 membered heteroaryl)-C1-4alkyl, and (4-7 membered heterocycloalkyl)-C1-4alkyl, CN, NO2, ORa8, NHORa8, C(O)Rb8, C(O)NRc8Rd8, C(O)NRc8(ORa8), C(O)ORa8, NRc8Rd8, NRc8C(O)Rb8, NRc8C(O)ORa8, NRc8C(O)NRc8Rd8, NRc8(O)2Rb8, NRc8(O)2NRc8Rd8, S(O)2Rb8, and S(O)2NRc8Rd8, wherein the C1-3 alkyl, C2-4 alkenyl, C2-4 alkynyl, phenyl, C3-7 cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C1-4 alkyl, C3-7 cycloalkyl-C1-4 alkyl, (5-6 membered heteroaryl)-C1-4 alkyl, and (4-7 membered heterocycloalkyl)-C1-4 alkyl of R8 are each optionally substituted with 1, 2, or 3 independently selected R8A substituents;
each Ra8, Rb8, Rc8, and Rd8 is independently selected from H and C1-3 alkyl, wherein the C1-3 alkyl is optionally substituted with 1 or 2 independently selected R8A substituents;
each R8A is independently selected from halo, C1-3 alkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, CN, ORa81, SRa81, C(O)Rb81, C(O)NRc81Rd81, C(O)ORa81, OC(O)RVb81, OC(O)NRc81Rd81, NRc81Rd81, NRc81C(O)Rb81, NRc81C(O)ORa81, and NRc81C(O)NRc81Rd81, wherein the C1-3 alkyl, 5-6 membered heteroaryl, and 4-7 membered heterocycloalkyl of R8A are each optionally substituted with 1, 2, or 3 independently selected R8B substituents;
each Ra81, Rb81, Rc81 and Rd81 is independently selected from H, C1-3 alkyl, and 4-7 membered heterocycloalkyl, wherein the C1-3 alkyl and 4-7 membered heterocycloalkyl of Ra81, Rb81, Rc81 and Rd81 are each optionally substituted with 1, 2, or 3 independently selected R8B substituents;
or, any Rc81 and Rd81, attached to the same N atom, together with the N atom to which they are attached, form a 4-10 membered heterocycloalkyl group, wherein the 4-10 membered heterocycloalkyl group is optionally substituted with 1 or 2 independently selected R8B substituents;
each R8B is independently selected from halo, C1-3 alkyl, and 4-7 membered heterocycloalkyl, wherein the C1-3 alkyl is optionally substituted with 1 or 2 independently selected R8C substituents; and
each R8C is independently selected from OH, CN, halo, C1-3 alkyl, C1-3 haloalkyl, C1-3 alkoxy, and carboxy.