Patent ID: 11911522
Assignee: MYLAN INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 14:
15. A continuous process for the production of an adhesive
composition comprising:
a) pre-processing a non-granulated high molecular weight polyisobutylene (HMW PIB) having a molecular weight ranging from about 425,000 g/mol to about 800,000 g/mol in a single-screw extruder to form a bulk HMW PIB material, wherein said bulk HMW PIB material is in a compressed, continuous feed form;
b) extruding said bulk HMW PIB material having a molecular weight ranging from about 425,000 g/mol to about 800,000 g/mol in a twin-screw extruding apparatus, wherein said HMW PIB is extruded;
c) simultaneously extruding said extruded HMW PIB with low molecular weight polyisobutylene (LMW PIB) in said extruding apparatus to produce high shear so as to form an extruded melt; wherein said LMW PIB has a molecular weight ranging from about 36,000 g/mol to about 75,000 g/mol; and wherein a ratio of the amount of HMW PIB to LMW PIB in said melt ranges from about 50:50 to about 70:30;
d) adding an active pharmaceutical ingredient to said extruded melt to produce an extruded API/PIB melt; and
e) discharging said extruded API/PIB melt to a die to form said adhesive composition, wherein said adhesive composition comprises about 93% to about 97% PIB and about 3% to about 7% API.