Patent ID: 11945872
Assignee: REGENERON PHARMACEUTICALS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 16:
17. An isolated monoclonal antibody or antigen-binding fragment thereof that inhibits ACVR1-mediated and/or ACVR1(R206H)-mediated bone morphogenetic protein (BMP) signal transduction
wherein the antibody or antigen-binding fragment thereof comprises
three heavy chain CDRs contained within a HCVR comprising the amino acid sequence of SEQ ID NO: 42; and three light chain CDRs contained within a LCVR comprising the amino acid sequence of SEQ ID NO: 48; or
three heavy chain CDRs contained within a HCVR comprising the amino acid sequence of SEQ ID NO: 58; and three light chain CDRs contained within a LCVR comprising the amino acid sequence of SEQ ID NO: 62.