Patent ID: 11971409
Assignee: BRUKER CELLULAR ANALYSIS, INC.
Field: Measurement (Instruments)
Classification: CPC G  A  B  C | IPC B  C  G

Claim 0:
1. A method of identifying an isolated B cell that produces antibodies capable of binding to a cancer cell-associated antigen comprising:
loading a dissociated cell sample from at least one solid tumor sample obtained from a patient into a microfluidic device having at least one flow region and at least one sequestration chamber comprising an isolation region, wherein the isolation region is fluidically connected to the flow region;
moving at least one B cell from the dissociated cell sample into at least one isolation region in the microfluidic device, thereby obtaining at least one isolated B cell; and
identifying at least one isolated B cell that produces antibodies capable of binding to a cancer cell-associated antigen by introducing the cancer cell-associated antigen into the microfluidic device.