Patent ID: 11939635
Assignee: REGENERON PHARMACEUTICALS, INC.
Field: Biotechnology (Chemistry)
Classification: CPC C | IPC C

Claim 10:
11. A method of identifying and treating a subject having an increased risk of developing obesity and/or increased body mass index (BMI), the method comprising:
identifying a subject having an increased risk of developing obesity and/or increased body mass index (BMI) by determining or having determined the presence of a Calcitonin Receptor (CALCR) variant nucleic acid molecule encoding a CALCR predicted loss-of-function polypeptide in a biological sample obtained from the subject;
wherein the CALCR predicted loss-of-function polypeptide comprises S18P, R92C, K125fs, I178V, S209N, R355O, F390V, V392I, A422V, R432C, S456F, R461fs, or N487fs; and
administering a therapeutic agent that treats or inhibits obesity and/or increased BMI to a subject that is heterozygous or homozygous for the CALCR variant nucleic acid molecule.