Patent ID: 11878073
Assignee: ENTRINSIC, LLC
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  G | IPC A  G

Claim 0:
1. A method of manufacturing a beverage formulation comprising:
obtaining, by at least one processor, the beverage formulation comprising an optimized amino acid-based combination by:
determining
a first set of optimization criteria comprising:
a first value of a water uptake metric, the first value being for glucose,
a taste profile metric associated with a score indicative of an effect on a taste profile of the hydration beverage;

determining a second set of optimization criteria, comprising:
an expression pattern for at least one associated receptor in the intestine;
a second value of the water uptake metric, the second value being for the amino acid formulation;
amino acid data comprising:
a plurality of amino acid fixed properties of each amino acid of a plurality of amino acids, wherein the fixed properties comprise:
 an average stoichiometry for each amino acid, and
 a molecular weight for each amino acid;
a plurality of amino acid variable characteristics of each amino acid of the plurality of amino acids, wherein the variable characteristics comprise:
 a molar concentration for each amino acid;

iteratively simulating a plurality of amino acid-based combination simulations, each amino acid-based combination simulation simulating the second value of the water uptake metric for a candidate amino acid-based combination of a plurality of candidate amino acid-based combinations based at least in part on transport kinetics modelling of each candidate amino acid-based combination to obtain the optimized amino acid-based combination comprising a plurality of selected amino acids having at least one concentration;
wherein each candidate amino acid-based combination comprises a combination of a plurality of candidate amino acids and a concentration of the plurality of candidate amino acids;
wherein the plurality of amino acid-based combination simulations is configured to optimize:
 the combination of the one or more candidate amino acids of the plurality of amino acids so as to obtain the plurality of selected amino acids and
 the concentration of the one or more candidate amino acids of the plurality of amino acids so as to obtain the at least one concentration of the plurality of selected amino acids;
 wherein the plurality of amino acid-based combination simulations is configured to optimize based at least in part on:
 the first set of optimization criteria, and
 the second set of optimization criteria; and

automatically sending, by the at least one processor, a control signal to production equipment at a manufacturing facility to dispense the plurality of selected amino acids having at least one concentration to produce the beverage formulation.