Patent ID: 11952420
Assignee: BRISTOL-MYERS SQUIBB COMPANY
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A nucleic acid encoding heavy and light chains of an antibody which specifically binds to TREM-1, the antibody comprising a heavy chain CDR1, CDR2, CDR3; a light chain CDR1, CDR2, CDR3; and an IgG1 heavy chain constant region,
wherein the heavy chain CDR1, CDR2, and CDR3 comprises TYAMH (SEQ ID NO: 24), RIRTKSSNYATYYAASVKG (SEQ ID NO: 25), and DMGIRRQFAY (SEQ ID NO: 26), respectively;
wherein the light chain CDR1, CDR2, and CDR3 comprises RASQSVDTFDYSFLH (SEQ ID NO: 27), RASNLES (SEQ ID NO: 28), and QQSNQDPYT (SEQ ID NO: 29), respectively;
wherein the IgG1 heavy chain constant region comprises amino acid substitutions selected from:
(i) L234A, L235E, and G237A, per EU numbering;
(ii) K214R, L234A, L235E, G237A, D356E, and L358M, per EU numbering;
(iii) K214R, L234A, L235E, G237A, A330S, P331S, D356E, and L358M, per EU numbering;
(iv) K214R, C226S, C229S, and P238S, per EU numbering; or
(v) S131C, K133R, G137E, G138S, Q196K, 1199T, N203D, K214R, C226S, C229S, and P238S, per EU numbering; and

wherein the IgG1 heavy chain constant region optionally comprises one or more amino acid deletions.