Patent ID: 11948684
Assignee: nan
Field: Medical technology (Instruments)
Classification: CPC G | IPC G

Claim 1:
2. The method of claim 1 wherein generating the matrix of of genes by training samples as input to the first PCA layer comprises:
obtaining the gene expression profile data from the National Center for Biotechnology Information Gene Expression Omnibus for the plurality of diseases and disease stages;
preprocessing the gene expression profile data by normalizing gene expression values across samples, filtering out genes with low expression values and low variance across samples;
generating using the preprocessed gene expression profile data, the training samples comprising two-thirds of samples in the true positives/controls patient biological samples, and the test/validation samples comprising one-third of samples in the true positives/controls patient biological samples;
performing the t-test on the training set, to eliminate genes with p-value<0.00001.