Patent ID: 11970529
Assignee: HEFEI LIFEON PHARMACEUTICAL CO., LTD.
Field: Measurement (Instruments)
Classification: CPC C  G  A | IPC A  C  G

Claim 0:
1. An isolated antibody or antigen-binding fragment thereof that specifically binds to an extra-domain B (ED-B) protein, wherein the isolated antibody or antigen-binding fragment comprises a light chain variable region (VL) and a heavy chain variable region (VH), wherein:
(i) the heavy chain variable region comprises:
a VH CDR1 comprising an amino acid sequence as set forth in SEQ ID NO: 5,
a VH CDR2 comprising an amino acid sequence as set forth in SEQ ID NO: 6, and
a VH CDR3 comprising an amino acid sequence as set forth in SEQ ID NO: 7; and
the light chain variable region comprises:
a VL CDR1 comprising an amino acid sequence as set forth in SEQ ID NO: 114,
a VL CDR2 comprising an amino acid sequence as set forth in SEQ ID NO: 138, and
a VL CDR3 comprising an amino acid sequence as set forth in SEQ ID NO: 10; or

(ii) the heavy chain variable region comprises:
a VH CDR1 comprising an amino acid sequence as set forth in SEQ ID NO: 5,
a VH CDR2 comprising an amino acid sequence as set forth in SEQ ID NO: 6, and
a VH CDR3 comprising an amino acid sequence as set forth in SEQ ID NO: 7; and
the light chain variable region comprises:
a VL CDR1 comprising an amino acid sequence as set forth in SEQ ID NO: 143,
a VL CDR2 comprising an amino acid sequence as set forth in SEQ ID NO: 144, and
a VL CDR3 comprising an amino acid sequence as set forth in SEQ ID NO: 10.