Patent ID: 11911359
Assignee: PDS BIOTECHNOLOGY CORPORATION
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 10:
11. A cationic lipid complex comprising a liposome, together with at least one tumor-associated antigen and a non-ionic buffer,
wherein the liposome comprises one or more cationic lipids,
wherein the one or more cationic lipids consists of a quaternary cationic lipid,
wherein the one or more cationic lipids is in an amount sufficient to induce cytokine and chemokine production in a mammal above the level of cytokine and chemokine production present in the absence of the cationic lipid complex,
wherein the cationic lipid is in an amount sufficient to both activate the ERK or p38 components of the MAP kinase signaling pathway and to induces the production of reactive oxygen species by at least 1.2-fold but less than 20-fold over baseline levels,
and wherein the cationic lipid complex is free of phosphate buffered saline (PBS); and
wherein the disease-associated antigen is a protein or peptide.