Patent ID: 11890340
Assignee: THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C  G | IPC A  C  G

Claim 10:
11. A method to target a molecule to alveolar epithelial type 1 cells in a subject with a lung disorder comprising co-administering the molecule with an agent that binds EMP2,
wherein the agent is an anti-EMP2 antibody selected from the group consisting of PG101, KS83, KS49, KS41, KS89, and a combination thereof, or an antigen-binding fragment thereof,
wherein the lung disorder is
(i) an acute disease selected from the group consisting of acute lung injury, acute respiratory distress syndrome, pneumonia, viral infection, and airway hyperresponsiveness;
(ii) a neutrophil-dependent lung disorder;
(iii) an epithelial lipid raft-dependent and/or caveolae-dependent lung disease;
(iv) a TGF-β (Transforming growth factor beta)-mediated lung disorder selected from the group consisting of pulmonary fibrosis and acute lung injury;
(v) an eosinophil-dependent lung disorder selected from the group consisting of asthma, acute eosinophilic pneumonia, and chronic eosinophilic pneumonia; or a monocyte-dependent lung disorder selected from the group consisting of lung fibrosis and acute lung injury; or a lymphocyte-dependent lung disorder selected from the group consisting of lymphocytic interstitial pneumonia and lymphocytic bronchiolitis;
(vi) idiopathic pulmonary fibrosis comprising epithelium-matrix interaction;
(vii) a chronic disease selected from the group consisting of chronic obstructive pulmonary disease (COPD), bronchiectasis, radiation- or chemotherapeutic-induced pneumonitis, idiopathic or induced interstitial lung disease, bronchopulmonary dysplasia, and lung fibrosis;
(viii) a lung disorder due to exposure to a toxic agent selected from the group consisting of a bioterroristic agent, an occupational hazardous agent and an environmental pollutant or
(ix) chemical pneumonitis due to chemical or acid or hydrocarbon aspiration; or chemical pneumonitis due to smoke inhalation.