Patent ID: 11959103
Assignee: OSAKA UNIVERSITY
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 0:
1. A method for inducing pluripotent stem cells to differentiate into somatic cells, the method comprising bringing pluripotent stem cells into contact with a conjugate of a laminin E8 fragment and a growth factor binding domain-containing fragment of a heparan sulfate proteoglycan in a culture medium containing a heparin binding growth factor and a canonical Wnt signal activator,
wherein the somatic cells are mesoderm-derived somatic cells, and
wherein the heparin binding growth factor is one or more selected from the group consisting of bone morphogenetic protein 4, activin A, basic fibroblast growth factor, hepatocyte growth factor and vascular endothelial growth factor.