Patent ID: 11920194
Assignee: BIONTECH SE
Field: Biotechnology (Chemistry)
Classification: CPC C | IPC C

Claim 1:
2. The method of claim 1, wherein identifying a chromosomal deletion and inversion event in a chromosome 15 comprises detecting the presence or absence of a nucleic acid sequence comprising a sequence selected from the group consisting of:
(i) a sequence identifying a chromosomal deletion and inversion event in a chromosome 15, wherein the deletion and inversion event results in the loss of the beta-2-microglobulin (B2M) locus, and comprising the sequence set forth in SEQ ID NO: 9, the sequence set forth in SEQ ID NO: 9 surrounding the end point of the deletion, which is the start point of the inverted region,
(ii) the sequence set forth in SEQ ID NO: 17 or a portion thereof of at least 40 nucleotides comprising the sequence set forth in SEQ ID NO: 10,
(iii) the sequence set forth in SEQ ID NO: 21 or a portion thereof of at least 40 nucleotides comprising the sequence set forth in SEQ ID NO: 10,
(iv) a sequence complementary to the sequences set forth in any one of (i) to (iii), and
(v) a sequence which is at least 90% identical to the sequences set forth in any one of (i) to (iv), wherein detection of the nucleic acid sequence indicates the presence of a chromosomal deletion and inversion event in a chromosome 15 that is predictive of a genotype for loss of antigen presentation via MHC class I.