Patent ID: 11879848
Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Field: Measurement (Instruments)
Classification: CPC G  C | IPC C  G

Claim 14:
15. A method of measuring mechanical movements in a biological sample, the method comprising:
placing a biological sample on a composite film structure, the composite film structure comprising a metallic layer in contact with a graphene layer, and a polymer layer in contact with either the metallic layer or the graphene layer, wherein the metallic layer comprises a plurality of self-assembled metallic nanoislands in direct contact with the graphene layer, wherein each of the plurality of self-assembled metallic nanoislands are uniquely shaped and variably spaced apart from each other;
placing the composite film structure including the biological sample into a chamber;
optically observing a change in a wavelength of optical light reflected or scattered from the biological sample on the composite film structure in the chamber;
determining, based on the observed change in the wavelength of optical light, a change in distance between metallic nanoislands of the plurality of self-assembled metallic nanoislands; and
determining a mechanical movement in the biological sample based on the determined change in distance.