Patent ID: 11896674
Assignee: SUZHOU RIBO LIFE SCIENCE CO., LTD.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 9:
10. The siRNA conjugate according to claim 1, wherein the sense strand further comprises nucleotide sequence 3, and the antisense strand further comprises a nucleotide sequence 4; the nucleotide sequence 3 and the nucleotide sequence 4 have a length of 1-4 nucleotides, respectively; the nucleotide sequence 3 is linked to 5′ terminal of the nucleotide sequence 1; and the nucleotide sequence 4 is linked to 3′ terminal of the nucleotide sequence 2; the nucleotide sequence 3 and the nucleotide sequence 4 have an equal length and are substantially reverse complementary or completely reverse complementary to each other; and wherein the nucleotide sequence 3 and the nucleotide sequence 4 both have a length of 1 nucleotide and the base of the nucleotide sequence 3 is G; or alternatively, the nucleotide sequence3 and the nucleotide sequence 4 both have a length of 2 nucleotides; in the direction from 5′ terminal to 3′ terminal, the bases of the nucleotide sequence 3 are U and G in succession; or alternatively, the nucleotide sequence 3 and the nucleotide sequence 4 both have a length of 3 nucleotides; in the direction from 5′ terminal to 3′ terminal, the bases of the nucleotide sequence 3 are U, U and G in succession; or alternatively, the nucleotide sequence 3 and the nucleotide sequence 4 both have a length of 4 nucleotides; in the direction from 5′ terminal to 3′ terminal, the bases of the nucleotide sequence 3 are A, U, U, and G in succession.