Patent ID: 11938180
Assignee: SECRETARY OF STATE FOR HEALTH AND SOCIAL CARE, MINISTERIAL CORRESPONDENCE AND PUBLIC ENQUIRIES, DEPARTMENT OF HEALTH AND SOCIAL CARE
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C  Y | IPC A  C

Claim 6:
7. The poliovirus-like particle (VLP) of claim 5, wherein said one or more additional modification within one or more of the pocket domain, the protomer interface and/or the pentamer is selected from the group consisting of:
(a) a pocket domain serotype 1 capsid stabilising modification selected from the group consisting of: V1196L; and/or
(b) a pocket domain serotype 2 capsid stabilising modification selected from the group consisting of: Y1159F, V1183L and I1194V; and/or
(c) a pocket domain serotype 3 capsid stabilising modification selected from the group consisting of: M1260I; and/or
(d) a protomer interface serotype 1 capsid stabilising modification selected from the group consisting of: T3108A, K1101E, E1168K, A1231V, A1231T, A1232V, D1236Y and D1247Y; and/or
(e) a protomer interface serotype 2 capsid stabilising modification selected from the group consisting of S2139L, T3108A, A3141G, T3175A, I3180T, F3184Y, T3229P, T1030S, T1041I, I1067L, 1104L deletion, V1107I, I1160V, S1179C, V1199M, S1222P, T1223S, A1231V, A1232V and L1234M; and/or
(f) a protomer interface serotype 3 capsid stabilising modification selected from the group consisting of: F3091S, I3190V, I1075V, I1181L, L1199I and I1155M; and/or
(g) a pentamer interface serotype 1 capsid stabilising modification selected from the group consisting of: L2014M, D2067N, L2251V, T2252S, E1040K, I1041V and K1218R; and/or
(h) a pentamer interface of serotype 2 capsid stabilising modification selected from the group consisting of: V2013L, I2014M, D2057E, D2057A, D2057N, I2246L, T2251S, N3073H, L3085F, A3141G and K1039R; and/or
(i) a pentamer interface serotype 3 capsid stabilising modification selected from the group consisting of: L2016I, I3190V and A1034V.