Patent ID: 11929144
Assignee: GENOME RESEARCH LIMITED
Field: Computer technology (Electrical engineering)
Classification: CPC G | IPC G

Claim 15:
16. The method of claim 15, further comprising:
determining, by said processor, the contribution of a second rearrangement signature to the rearrangement catalogue, the second rearrangement signature characterized by a presence of non-clustered tandem duplications greater than 100kb in length, the determining comprising computing the measure of similarity between the rearrangement mutations in said rearrangement catalogue and the second rearrangement signature;
determining that the second rearrangement signature characterized by the presence of non-clustered tandem duplications greater than 100kb in length is present in the DNA sample by determining if the number or proportion of rearrangements in the rearrangement catalogue which are determined to be associated with the second rearrangement signature characterized by the presence of non-clustered tandem duplications greater than 100kb in length exceeds a predetermined threshold;
selecting the subject for treatment with a particular cancer therapy for subjects whose cancer exhibit HRD when it is determined that the rearrangement signature characterized by the presence of non-clustered tandem duplications greater than 100kb in length is present in the DNA sample; and
administering the particular cancer therapy to the subject.