Patent ID: 11925685
Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C  Y | IPC A  C

Claim 0:
1. A nucleic acid molecule encoding one or more synthetic antibodies, wherein the nucleic acid molecule comprises at least one selected from the group consisting of
a) a nucleotide sequence encoding a variable light (VL) chain of an anti-ZIKV envelope (E) protein synthetic antibody, wherein the encoded sequence is selected from the group consisting of SEQ ID NO:2, and an antigen binding fragment thereof that retains all three LCDR regions thereof;
b) a nucleotide sequence encoding a variable heavy (VH) chain of an anti-ZIKV E protein synthetic antibody, wherein the encoded sequence is selected from the group consisting of SEQ ID NO:1, and an antigen binding fragment thereof that retains all three HCDR regions; and
c) a nucleotide sequence encoding a combination of a VL chain and VH chain of an anti-ZIKV envelope (E) protein synthetic antibody, wherein the encoded sequence is selected from the group consisting of SEQ ID NO:11, SEQ ID NO:12, SEQ ID NO:20, and an antigen binding fragment thereof that retains at least all three HCDR regions and all three LCDR regions.