Patent ID: 11873358
Assignee: MCMASTER UNIVERSITY
Field: Macromolecular chemistry, polymers (Chemistry)
Classification: CPC C | IPC C

Claim 9:
10. The crosslinked hydrogel as defined in claim 1, formed by reacting an amount of about 0.5 to 15 wt % of a synthetic side-chain functionalized polymer comprising poly(methyl-vinylether-alt-maleic anhydride) (PMMA) functionalized with cysteamine vinyl sulfone or S-(2-aminoethylthio)-2-thiopyridine, wherein cysteamine vinyl sulfone or S-(2-aminoethylthio)-2-thiopyridine comprises between 5 and 40 mol % of the anhydride groups present in the PMMA in aqueous solution with i) an aqueous solution containing di- or poly-thiol poly(ethylene glycol), wherein the poly(ethylene glycol) is present in a concentration that results in a molar ratio ranging from 1:4 to 4:1 of cysteamine vinyl sulfone groups on the synthetic polymer to thiols on the poly(ethylene glycol), or with ii) an aqueous solution of the protected polythiol polymer comprising poly(methylvinylether-alt-maleic anhydride)(PMMA) functionalized with S-(2-aminoethylthio)-2-thiopyridine, wherein crosslinking is initiated by addition of triscarboxyethylphosphine or its sodium salt, or THPP.