Patent ID: 11883475
Assignee: SANARIA INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C  Y | IPC A  C

Claim 0:
1. An in vitro-reared mature infectious Plasmodium sporozoites of human host range, wherein sporogony of the sporozoites from gametocyte stage to mature sporozoite stage is external to mosquitoes and absent any mosquito material, and wherein the genome of the in vitro-reared mature infectious Plasmodium sporozoites of human host range comprises a gene alteration or mutation, wherein the gene alternation or mutation disrupts the function of one or more genes, such that the in vitro-reared mature infectious Plasmodium sporozoites retain the ability to infect a host and invade hepatocytes within the liver, but arrest development in liver-stage.