Patent ID: 11896800
Assignee: NORTH CAROLINA STATE UNIVERSITY
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 0:
1. A method for treating a skin cancer in a subject in need thereof, comprising:
providing a microneedle patch to a subject, wherein the microneedle patch comprises:
a plurality of microneedles each having a base end and a tip;
a substrate to which the base ends of the microneedles are attached or integrated;
acid-degradable nanoparticles, wherein the nanoparticles encapsulate an immunotherapeutic agent and a pH altering agent;

inserting the microneedles into a biological barrier, wherein the pH altering agent decreases the pH within the acid-degradable nanoparticles, and wherein the decrease in the pH degrades the nanoparticle and releases the immunotherapeutic agent into the subject in a controlled-release manner;
wherein the immunotherapeutic agent comprises an anti-PD1 antibody and an anti-CTLA4 antibody.