Patent ID: 11862346
Assignee: OM1, INC.
Field: Medical technology (Instruments)
Classification: CPC G | IPC G

Claim 0:
1. A computer system for generating subtype definitions that map patients into subtypes, the computer system comprising:
a processing system comprising a processing device and computer storage, the processing device processing computer program instructions from the computer storage;
a source of patient data stored in the computer storage;
a sub-cohort analysis module comprising computer program instructions that, when processed by the processing system causes the processing system to:
access, from the computer storage, patient data for a plurality of patients in a training cohort,
map, for each patient in the training cohort, respective patient data for the patient to a respective N-dimensional vector for the patient, wherein each dimension of the N-dimensional vector for the patients in the training cohort comprises a medical instance computed by applying a respective medical instance definition for the dimension to the patient data, wherein the respective medical instance definitions produce medical instances for the patients having reduced dimensions and reduced inconsistency with respect to the patient data, thereby mapping each patient to a respective point for the patient in an N-dimensional space,
identify a plurality of clusters of the points in the N-dimensional space, each cluster in the plurality of clusters representing a distinct sub-cohort of the training cohort such that medical fact patterns of patients in each sub-cohort, as analyzed in the N-dimensional space, are closer to the patients in the sub-cohort than to patients in the other sub-cohorts,
for a first sub-cohort represented by a first cluster of the plurality of clusters, determine a first sub-cohort level outcome measure based on outcome measures based on patient data for patients in the first sub-cohort,
for a second sub-cohort represented by a second cluster of the plurality of clusters, determine a second sub-cohort outcome measure based on outcome measures based on patient data for patients in the second sub-cohort, and
in response to a comparison of the first sub-cohort level outcome measure and the second sub-cohort level outcome measure indicating that the first sub-cohort represents a medically interesting subtype, generate a quantitative definition for a subtype characterizing the first sub-cohort based on the medical instances derived from the patient data for patients in the first sub-cohort, wherein the quantitative definition comprises a mapping and a subtype definition, wherein the mapping comprises a data structure that stores, for each dimension of the N-dimensional vector, data defining the respective medical instance definition to be applied to patient data to generate the value for the respective dimension in a patient vector, and wherein the subtype definition comprises a data structure that stores logic indicating an operation to be performed to process a patient vector to determine membership of a patient in the subtype and parameters used by the operation.