Patent ID: 11890471
Assignee: SETPOINT MEDICAL CORPORATION
Field: Measurement (Instruments)
Classification: CPC A  G | IPC A  G

Claim 5:
6. An in vitro method for screening a patient for responsiveness to vagus nerve stimulation, the method comprising:
obtaining a sample of blood taken from the patient prior to stimulation of the patient's vagus nerve;
challenging the sample of blood with LPS at a first concentration of LPS;
measuring a level of an inflammatory cytokine that is released in response to the LPS challenge at the first concentration of LPS;
challenging the sample of blood with LPS at a second concentration of LPS that is at least 5 times the first concentration of LPS;
measuring a level of the inflammatory cytokine that is released in response to the LPS challenge at the second concentration of LPS; and
determining a response curve based on the level of the inflammatory cytokine that is released in response to the LPS challenges at the first concentration of LPS and the second concentration of LPS;
comparing the determined response curve to a cutoff; and
determining whether the patient is suitable for vagus nerve stimulation based on the comparison of the determined response curve to the cutoff.