Patent ID: 11898144
Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
Field: Biotechnology (Chemistry)
Classification: CPC C  H | IPC C  H

Claim 0:
1. A synthetic nucleic acid molecule comprising a NOT-OR (NOR) logic circuit, the NOR logic circuit comprising:
at least one input RNA sensing hairpin module comprising:
an input RNA binding domain; and
a loop domain;
wherein the input RNA binding domain is complementary to an input RNA; and wherein the loop domain comprises first and second trigger RNA sequences;

a near-threshold translational repressor (NeaTTR) hairpin module comprising:
a loop-forming region comprising a ribosomal binding site (RBS); and
a stem-forming region comprising a start codon; and

first and second trigger recognition sequences located 5′ and 3′ to the NeaTTR hairpin module, respectively;
wherein the first and second trigger recognition sequences are complementary to the first and second trigger RNA sequences, respectively, of the input RNA sending hairpin module.