Patent ID: 11957714
Assignee: XYPHOS BIOSCIENCES INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 0:
1. A non-natural, modified NKG2D receptor comprising a human NKG2D ectodomain that comprises a substitution at position 152 selected from alanine, serine, threonine or valine and/or a substitution at residue 199 which is phenylalanine, wherein the receptor is attached to a mammalian cell, and wherein the receptor binds to non-natural, modified α1-α2 domains of NKG2D ligands but not to natural ligands of NKG2D, and wherein the modified NKG2D receptor does not comprise an active CD3-zeta intracellular signaling domain and does not activate intracellular signaling in the mammalian cell upon formation of an immunological synapse.