Patent ID: 11883448
Assignee: UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 0:
1. A recombinant herpes simplex virus (HSV), comprising:
(a) a mutation of glycoprotein B (gB) at position 285 or 549; and
(b) a plurality of copies of one or more microRNA target sequences inserted into a locus of one or more HSV genes required for HSV replication,
wherein expression of one or more genes in the internal repeat (joint) region in the HSV genome is silenced, and
wherein the internal repeat (joint) region comprises one copy of the ICP0, ICP34.5, LAT, and ICP4 genes and the promoter of the ICP47 gene.