Patent ID: 11887302
Assignee: AMGEN INC.
Field: Computer technology (Electrical engineering)
Classification: CPC G | IPC G

Claim 15:
16. A system comprising:
a visual inspection system including
a stage configured to accept a well plate, and
an imaging unit configured to generate images of wells within the well plate, wherein each image corresponds to a single well; and

a computer system including
one or more processors, and
one or more memories storing instructions that, when executed by the one or more processors, cause the computer system to
pre-process a well image, generated by the imaging unit and depicting a well containing cells and a medium, at least in part by partitioning the well image into a plurality of sub-images each corresponding to a different portion of the well,
for each of some or all of the plurality of sub-images, determine, by analyzing the sub-image using a convolutional neural network, a respective score indicative of a likelihood that any cells in the portion of the well corresponding to the sub-image exhibit CPE,
determine a CPE status of the cells contained in the well based on the respective scores for the plurality of sub-images,
generate output data indicating the CPE status; and
wherein, if the respective score indicative of the likelihood that any cells in the portion of the well corresponding to the sub-image exhibit CPE exceeds a specified threshold, the instructions cause the computer system to cease the analysis, and to determine the CPE status based on the respective score exceeding the specified threshold.