Patent ID: 11865149
Assignee: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C  G | IPC A  C  G

Claim 15:
16. A method for treating cancer in a mammal, wherein said method comprises:
(a) identifying said mammal as having cancer cells that express:
(1) a low level of a majority of the genes selected from the Gene Set 5 group consisting of MX1, MX2, OAS2, OASL, APOBEC3G, ISG15, GBP2, IRF2, MAP3K14, MOV10 and RTP4, as compared to expression by healthy control cells of the same tissue type as the cancer cells;
(2) a low level of a majority of the genes selected from the Gene Set 6 group consisting of DDX60, NFKBIA, MAPK8, MAPK11, MAPK12, TRAF3, DHX58, IKBKG, RIPK1, AKT3, TAB1, TICAM1, PIK3R5, IFNAR2, TICAM2, IRF5, MYD88, PIK3CG, TLR9, TOLLIP, TLR3, TLR4, TLR5, PIK3R3, CD14, CASP1, STAM2, IRF9, FHL1, MTOR, STAT2, STAT3 and STAT5A, as compared to expression by healthy control cells of the same tissue type as the cancer cells; and
(3) a low level of a majority of the genes selected from the Gene Set 7 group consisting of PDIA3, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, B2M, PSME1, PSME2, TAP1, TAP2, TAPBP, CALR, PSMB8, PSMB9, ERAP1, ERAP2 and TAPBPL, as compared to expression by healthy control cells of the same tissue type as the cancer cells; and
(b) administering an oncolytic virus to said mammal under conditions, wherein the number of cancer cells within the mammal is reduced.