Patent ID: 11873478
Assignee: BIONTECH SE
Field: Biotechnology (Chemistry)
Classification: CPC C | IPC C

Claim 0:
1. A modified RNA comprising an adenosine-rich first nucleotide sequence having an adenosine content of more than 25% and encoding at least one peptide or protein; wherein the peptide or protein encoded by the first nucleotide sequence is also encoded by a second nucleotide sequence of a second, naturally occurring RNA; and the first nucleotide sequence has a higher A content and a lower U content compared to the second nucleotide sequence; wherein the first nucleotide sequence comprises nucleotide residues selected from adenosine (A), guanosine (G), and cytidine (C) at positions corresponding to uracil (U) nucleotide residue positions in the second nucleotide sequence; thereby rendering the modified RNA at least 5% less immunogenic than the second RNA.