Patent ID: 11858893
Assignee: KING FAISAL UNIVERSITY
Field: Organic fine chemistry (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A method of treating a cancer in a patient, comprising administering to a patient in need thereof a therapeutically effective amount of a compound having the formula I:, or a pharmaceutically acceptable salt, ester, stereoisomer, or solvate thereof, wherein
 represents a single or double bond,
n is 1;
W represents oxygen (O) or sulfur (S);
X represents an oxygen, sulfur, CH2, or —NR7 wherein R7 represents a hydrogen atom or a linear or branched (C1-C6)alkyl group, a (C3-C9)cycloalkyl group, a (C1-C6)alkyl-aryl group, an aryl group, or a heteroaryl group;
R1 represents:
a hydrogen atom,
aryl,
heteroaryl,
(C3-C9) cycloalkyl group,
linear or branched (C1-C6) alkyl group, optionally substituted by an aryl group, a heteroaryl group, a hydroxy group, a linear or branched (C1-C6) alkoxy group, a carboxylic acid group, a group of formula —CONR8R9 or —NR8R9, wherein R8 and R9, which may be the same or different, each independently represent a linear or branched (C1-C6)alkyl group optionally substituted by a hydroxy group or an amino group (itself optionally substituted by one or two linear or branched (C1-C6) alkyl groups), or R8 and R9, together with the nitrogen atom to which they are attached, form a nitrogen-containing heterocycle,
an amino group optionally substituted by one or more aryl groups, heteroaryl groups, or linear or branched (C1-C6) alkyl groups or (C3-C6) cycloalkyl groups optionally substituted by a carboxylic acid group, or by a group of formula —CONR8R9 or —NR8R9, or
—OR10 wherein R10 represents a hydrogen atom, an aryl group, a heteroaryl group, or a linear or branched (C1-C6) alkyl group or a (C3-C6) cycloalkyl group optionally substituted by a carboxylic acid group, or by a group of formula —CONR8R9 or —NR8R9;

R2, R3, R4, and R5, which may be the same or different, each represent:
a hydrogen atom,
a halogen atom,
a hydroxy group,
a nitro group,
a linear or branched (C1-C6) polyhaloalkyl group,
a linear or branched (C1-C6) alkyl group,
—OR10,
an amino group,
a substituted amino group optionally substituted by one or more aryl groups, heteroaryl groups, or linear or branched (C1-C6) alkyl groups or (C3-C6) cycloalkyl groups optionally substituted by a carboxylic acid group, by a carbonyl group, or by a group of formula —CONR8R9 or —NR8R9,
—OPO(OH)2,
an acyl group,
a carboxylic acid group,
a sulfonyl group,
a sulfonamide group, or
a cyano group; and

R6 is a hydrogen atom, a linear or branched (C1-C6) alkyl group, a (C3-C6) cycloalkyl group, or an aryl or heteroaryl group optionally substituted in one or more positions with one or more of R2, R3, R4, and R5, each of which may be the same or different,
wherein the cancer is selected from the group consisting of breast cancer, lung cancer, and leukemia.