Patent ID: 11866710
Assignee: ALNYLAM PHARMACEUTICALS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 23:
24. A composition, or a pharmaceutically acceptable salt thereof, comprising a sense strand and an antisense strand,
wherein the sense strand consists of the nucleotide sequence 5′-asgscugcccUfUfUfggaauaaaguL96-3′ (SEQ ID N0:395) and the antisense strand consists of the nucleotide sequence 5′-asdCsuudTadTuccadAaGfggcagcusgsa-3′ (SEQ ID NO:521),
wherein a, g, c and u are 2′-O-methyl (2′-OMe) A, G, C, and U, respectively; Gf and Uf are 2′-deoxy-2′-fluoro (2′-F) G and U, respectively; dC, dA, and dT are 2′-deoxy C, A, and T, respectively; and s is a phosphorothioate linkage, and
wherein L96 is a ligand conjugated to the 3′-end of the sense strand as shown in the following schematic, , and wherein X is O.