Patent ID: 11884747
Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A compound comprising:
(a) a compstatin or compstatin analog peptide having an amino acid sequence represented by SEQ ID NO:1, SEQ ID NO:2, SEQ NO:3, SEQ ID NO:4, SEQ ID NO: 5, SEQ ID NO: 6, or SEQ ID NO:7; and
(b) a terminal modification comprising an added terminal component that improves (1) the peptide's C3, iC3b, C3b or C3c binding affinity, (2) the peptide's solubility at physiological pH, (3) the peptide's plasma stability and/or plasma residence time, and/or (4) the peptide's vitreous stability and/or vitreous residence time, as compared with an unmodified compstatin peptide under equivalent conditions;, wherein the added terminal component:
(i) is a C-terminal component comprising two or three lysine amino acid residues; or
(ii) is an N-terminal component comprising polyethylene glycol (PEG) having an average molecular weight of about 1 kDa to about 3 kDa, or
(iii) both (i) and (ii).