Patent ID: 11965879
Assignee: MCMASTER UNIVERSITY
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  G  C  B | IPC A  C  G

Claim 8:
9. A method of diagnosing and treating endometriosis in a mammal comprising:
i) detecting the expression level of at least 5 miRNA markers selected from the group of miR-199a-3p, miR-143-3p, miR-340-5p, let-7b-5p, miR-21-5p, miR-17-5p, miR-20a-5p and miR-103a-3p, in a biological sample obtained from the mammal;
ii) detecting the expression level of an miRNA reference marker selected from miR-148b-3p and miR-30e-5p in the biological sample obtained from the mammal;
iii) normalizing the expression level of the miRNA markers based on the expression level of the miRNA reference marker in the sample and in a control; and
iv) treating the mammal in which the normalized expression levels of the miRNA markers are less than the expression level of the miRNA markers in the control with a treatment selected from hormone therapy, gonadotropin-releasing hormone (Gn-RH) agonists, Gn-RH antagonists and steroid treatment.