Patent ID: 11866743
Assignee: TELEDYNE FLIR DETECTION, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A method for treating chemical warfare agent exposure in a patient, comprising:
administering a first effective amount of a composition comprising:
a first organophosphorus hydrolase (OPH) protein:polymer conjugate that comprises:
at least a first genetically-modified OPH protein, selected from the group consisting of OPH YT protein, OPH C23 protein, and OPH IVH3 protein; and
at least a first polymer conjugated thereto, wherein the polymer has a molecular weight in a range of 175 kDa to 222 kDa and comprises a polyethylene glycol methyl-ethyl methacrylate (PEGMA) chain; and

a pharmaceutically-acceptable buffer;

wherein an in vivo kcat/km of the first OPH protein:polymer conjugate is one or both of:
≥I×107 for at least one G-series chemical warfare agent; and
≥I×105 for at least one V-series chemical warfare agent.