Patent ID: 11969504
Assignee: MANTRA BIO, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 0:
1. A non-naturally occurring exosome comprising a chimeric vesicle localization moiety comprising
a. surface-and-transmembrane domain of a first vesicle localization moiety, wherein the first vesicle localization moiety, is lysosome-associated membrane protein 2, isoform B (LAMP2B) and
b. a cytosolic domain of a second vesicle localization moiety, wherein the second vesicle localization moiety is selected from the group consisting of calsyntenin 1 (CLSTN1), interleukin 3 receptor subunit alpha (IL3RA), integrin subunit alpha 3 (ITGA3), integrin subunit beta 1 (ITGB1), prostaglandin F2 receptor negative regulator (PTGFRN), and selectin P ligand (SELPLG),, wherein the first and second vesicle localization moieties are single pass transmembrane proteins.