Patent ID: 11946047
Assignee: TEXAS TECH UNIVERSITY SYSTEM
Field: Biotechnology (Chemistry)
Classification: CPC C | IPC C

Claim 0:
1. A composition for decreasing virulence or toxicity of Bacillus anthracis to a host comprising:
inhibitors that decrease an expression of host genes Fosl2, Hcar2, Cxcl2, and Cxcl3, wherein a decrease in the expression of the host genes reduces a cell surface expression of Hcar2, and expression of Fosl2, Cxcl2 and Cxcl3, and wherein the reduction in expression of Hcar2, and Fosl2, Cxcl2, and Cxcl3, decreases the virulence or toxicity of the Bacillus anthracis to the host cell, wherein the inhibitors comprise an RNA molecule active for gene silencing through RNA interference (RNAi) against Fosl2 selected from SEQ ID NOS: 32, 34, or 36; against Hcar2 selected from SEQ ID NOS: 26, 28, or 30; against Cxcl2 selected from SEQ ID NOS: 46 and 48; and against Cxcl3 selected from SEQ ID NOS: 50 and 52.