Patent ID: 11869630
Assignee: CONGENICA LTD.
Field: Computer technology (Electrical engineering)
Classification: CPC G | IPC G

Claim 0:
1. A screening system comprising:
a wet-laboratory arrangement configured to determine a presence of cell-free DNA fragments in a biological sample comprising one or more maternal blood samples from a pregnant mother by enriching cell free fetal DNA fragments present in cell-free DNA derived from plasma of the one or more maternal blood samples that start within a nucleosome and have a shorter nucleic acid base count than an average length nucleic acid base count of cell-free DNA in the one or more maternal blood samples to sequence the cell-free DNA fragments; and
a data processing arrangement comprising a non-transitory computer-readable storage medium comprising computer instructions, wherein the data processing arrangement under control of the computer instructions is configured to:
compare information representative of the sequenced DNA fragments against information stored in a genomic database arrangement to provide an assessment score with respect to the biological sample; and
apply a modification to one or more stochastic ratings associated with the information representative of the sequenced DNA fragments using secondary information provided to the screening system to reduce a stochastic and/or systemic uncertainty present in the assessment score.