Patent ID: 11951240
Assignee: GAMBRO LUNDIA AB
Field: Medical technology (Instruments)
Classification: CPC A | IPC A

Claim 0:
1. A continuous renal replacement therapy (CRRT) apparatus comprising:
a filtration unit having a primary chamber and a secondary chamber separated by a semi-permeable membrane;
a blood circuit having a blood withdrawal line connected to an inlet of the primary chamber, and a blood return line connected to an outlet of the primary chamber, said blood circuit being configured for connection to a patient cardiovascular system;
a blood pump to circulate blood in the blood circuit;
a dialysis supply line connected to an inlet of the secondary chamber;
a dialysate line connected to an outlet of the secondary chamber;
one or more lines to transfer a respective solution into blood comprising an infusion line connecting for directly infusing into the blood a substitute solution including bicarbonate;
an infusion pump operating on the infusion line to deliver a replacement infusion rate;
a replacement solution bag connected to an end of the infusion line for infusing a solution including bicarbonate into blood;
at least one fluid source of a solution for each of said one or more lines, wherein said solution comprises at least one buffer agent in the form of bicarbonate or bicarbonate precursor;
a control unit configured to receive a patient prescription to set and deliver a CRRT blood treatment to the patient using the CRRT apparatus, the patient prescription including one or more of a blood flow rate in the blood circuit, a dialysis flow rate of dialysis fluid in the dialysis supply line, a patient fluid removal rate to be removed from the patient, wherein the control unit is further configured to calculate a steady state acid-base balance parameter in the blood of the patient who has to undergo a CRRT blood treatment, wherein said steady state acid-base balance parameter is calculated as a function of the concentration of said at least one buffer agent in said fluid source and as a function of the estimated or calculated patient systemic steady state concentration of bicarbonate and bicarbonate precursors;
wherein the control unit is configured to calculate the steady state acid-base balance parameter in the blood of the patient through a calculation of a bicarbonate balance from the CRRT blood treatment to be delivered in terms of an amount per unit of time, the calculation of the bicarbonate balance being a function of a replacement flow rate and bicarbonate concentration in the replacement solution;
wherein the control unit is further configured to calculate the steady state acid-base balance parameter in the blood of the patient as a function of one or more of:
an estimation of an amount per unit of time of bicarbonate generated from metabolism of the bicarbonate precursor infused to the patient;
a calculation of a lactate balance from the CRRT blood treatment to be delivered in terms of an amount per unit of time;
a calculation of an acid infusion from citric acid contained in the fluid source in terms of an amount per unit of time;

wherein the control unit is further configured to:
compare the steady state acid-base balance parameter in the blood of the patient with a threshold, and
generate an alert when the steady state acid-base balance parameter exceeds the threshold.