Patent ID: 11884725
Assignee: AMPSOURCE BIOPHARMA SHANGHAI INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 7:
8. The antibody or the antigen-binding fragment thereof according to claim 7, further comprising a heavy chain constant region and a light chain constant region,
wherein the light chain constant region is a κ light chain constant region and the heavy chain constant region is selected from:
(1) a heavy chain constant region of human IgG1;
(2) a heavy chain constant region of human IgG4;
(3) a variant of the heavy chain constant region of human IgG1, wherein, relative to a wild-type sequence from which the variant is derived, the variant has a substitution(s): Leu234Ala, Leu235Ala;
(4) a variant of the heavy chain constant region of human IgG1, wherein, relative to a wild-type sequence from which the variant is derived, the variant has a substitution: Asn297Ala;
(5) a variant of the heavy chain constant region of human IgG1, wherein, relative to a wild-type sequence from which the variant is derived, the variant has a substitution(s): Asp265Ala, Pr391; or
(6) a variant of the heavy chain constant region of human IgG4, wherein, relative to a wild-type sequence from which the variant is derived, the variant has a substitution: Ser228Pro;
wherein amino acid positions above are positions according to an EU numbering system.