Patent ID: 11883432
Assignee: CENTURY THERAPEUTICS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A universal chimeric antigen receptor system having an adaptable receptor specificity component (arCAR), comprising
(i) an immune effector cell having a chimeric antigen receptor comprising a first polypeptide comprising:
(a) an extracellular tag-binding domain,
(b) a transmembrane domain, and
(c) at least one intracellular signaling domain; and

(ii) a second soluble polypeptide comprising:
(a) an antigen-binding domain that binds to at least one antigen on a target cell, and
(b) a tag that is recognized by the extracellular tag-binding domain;, wherein:
the tag comprises the polypeptide sequence of SEQ ID NO: 112, and the extracellular tag-binding domain comprises the polypeptide sequence of SEQ ID NO: 129; or
the tag comprises the polypeptide sequence of SEQ ID NO: 129, and the extracellular tag-binding domain comprises the polypeptide sequence of SEQ ID NO: 112.