Patent ID: 11932870
Assignee: FATE THERAPEUTICS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A  G  Y | IPC A  C

Claim 0:
1. A method of treating a human subject in need thereof, the method comprising administering to the human subject a therapeutic composition comprising a population of modulated immune cells, wherein:
(a) the modulated immune cells are cells produced by culturing a population of immune cells in a culture medium to produce the modulated population of immune cells, wherein
(i) the culturing comprises inhibiting BCR-ABL tyrosine kinase; and
(ii) the culturing increases the number or ratio of one or more subpopulations comprising T cells expressing one or both of CD62L and CCR7; and
(b) the therapeutic composition comprises the T cells expressing one or both of CD62L and CCR7 in a therapeutically sufficient amount for adoptive cell therapy in said human subject in need thereof.