Patent ID: 11884672
Assignee: VERTEX PHARMACEUTICALS INCORPORATED
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 3:
4. The compound, tautomer, salt, or deuterated derivative according to claim 1, wherein the compound is a compound of Formula (I-A), (I-B), (I-C), (I-D), (I-E), (I-F), (I-G), or (I-H):, , wherein:
R0, R1, R2, R3, and n are defined in claim 1,
each of X1 and X2, independently, is hydrogen or fluorine, or X1 is fluorine and X2 is hydrogen, or X2 is fluorine and X1 is hydrogen, or X1 and X2 are each hydrogen,
each of W1 and W2, independently, is C or N,
each of Y1, Y2, Y3, and Y4, independently, is a
hydrogen,
cyano,
halogen,
C1-C6 linear, branched, or cyclic alkyl group, or
C1-C6 linear, branched, or cyclic alkoxy group optionally substituted with 1-4 substituents, wherein each substituent independently is a
hydroxy,
C1-C6 linear, branched, or cyclic alkyl group, and
C1-C6 linear, branched, or cyclic alkoxy group;

each of Y5, Y6, Y7, and Y8, independently, is a
hydrogen,
halogen,
hydroxy,
C1-C6 linear, branched, or cyclic alkyl group optionally substituted with 1-4 independently chosen halogen substituents, or
C1-C6 linear, branched, or cyclic alkoxy group,

each of Y9, Y10, Y11, Y12, Y13, Y14, Y15, and Y16, independently, is a
carboxylic acid,
hydrogen,
halogen,
C1-C6 linear, branched, or cyclic alkylsulfonyl group,
C1-C6 linear, branched, or cyclic alkyl group optionally substituted with 1-4 independently chosen halogen substituents, or
C1-C6 linear, branched, or cyclic alkoxy group,

each of Y17, Y18, Y19, Y20, and Y21, independently, is a
hydrogen,
carboxylic acid,
halogen,
cyano,
hydroxy,
C1-C6 linear, branched, or cyclic alkyl group that is optionally substituted with 1-4 substituents, wherein each substituent, independently, is a
halogen,
hydroxy, or
carboxylic acid,

C1-C6 linear, branched, or cyclic alkoxy group optionally substituted with a carboxylic acid group,
dihydroxyboryl,
sulfonic acid,
carboxylic acid optionally esterified with a uronic acid,
tetrazolyl group,
aminosulfonyl group, optionally substituted with 1 or 2 substituents,
wherein each substituent, independently, is a
C1-C6 linear, branched, and cyclic alkyl group, or
C1-C6 linear, branched, or cyclic alkylsulfonyl group,

with the proviso that, in Formula (I-E), at least one of Y17, Y18, Y19, Y20, and Y21 is hydrogen.