Patent ID: 11897905
Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 1:
2. The polymer of claim 1, wherein each instance of the first monomer is independently of Formula (A1) or (A2):, or a salt thereof;
wherein:
each instance of, is Ring B, wherein each instance of Ring B is independently a substituted or unsubstituted, monocyclic carbocyclic ring, substituted or unsubstituted, monocyclic heterocyclic ring, substituted or unsubstituted, monocyclic aryl ring, or substituted or unsubstituted, monocyclic heteroaryl ring;
each instance of Z is independently C(RP)2 or O;
each instance of RP is independently hydrogen, halogen, or substituted or unsubstituted, C1-6 alkyl;
each instance of  is independently a single bond or double bond;
each instance of L1, L2, L3a, and L3b is independently a single bond, substituted or unsubstituted, C1-200 alkylene, substituted or unsubstituted, C2-200 alkenylene, substituted or unsubstituted, C2-200 alkynylene, substituted or unsubstituted, C2-200 heteroalkylene, substituted or unsubstituted, C2-200 heteroalkenylene, or substituted or unsubstituted, C2-200 heteroalkynylene;
each instance of R1, R2, R3, and R4 is independently hydrogen, halogen, or substituted or unsubstituted, C1-6 alkyl, or two instances of R1 attached to the same carbon atom are taken together to form oxo, or two instances of R2 attached to the same carbon atom are taken together to form oxo, or two instances of R3 attached to the same carbon atom are taken together to form oxo, or two instances of R4 attached to the same carbon atom are taken together to form oxo;
each instance of W1 and W2 is independently a single bond,, each instance of RL is independently hydrogen, a nitrogen protecting group when attached to a nitrogen atom, or -L(M)m;
each instance of M is independently hydrogen or an agent;
each instance of m is independently an integer between 1 and 10, inclusive;
each instance of L is independently substituted or unsubstituted, C1-200 alkylene, substituted or unsubstituted, C2-200 alkenylene, substituted or unsubstituted, C2-200 alkynylene, substituted or unsubstituted, C2-200 heteroalkylene, substituted or unsubstituted, C2-200 heteroalkenylene, or substituted or unsubstituted, C2-200 heteroalkynylene;
optionally one or more carbon atoms in each instance of the substituted or unsubstituted, C1-200 alkylene, substituted or unsubstituted, C2-200 alkenylene, substituted or unsubstituted, C2-200 alkynylene, substituted or unsubstituted, C2-200 heteroalkylene, substituted or unsubstituted, C2-200 heteroalkenylene, and substituted or unsubstituted, C2-200 heteroalkynylene are independently replaced with substituted or unsubstituted carbocyclylene, substituted or unsubstituted heterocyclylene, substituted or unsubstituted arylene, or substituted or unsubstituted heteroarylene;
optionally one or more heteroatoms in each instance of the substituted or unsubstituted, C2-200 heteroalkylene, substituted or unsubstituted, C2-200 heteroalkenylene, and substituted or unsubstituted, C2-200 heteroalkynylene are independently replaced with substituted or unsubstituted carbocyclylene, substituted or unsubstituted heterocyclylene, substituted or unsubstituted arylene, or substituted or unsubstituted heteroarylene;
each instance of e and f is independently an integer between 0 and 10, inclusive;
each instance of X1 and X2 is independently hydrogen, substituted or unsubstituted, C1-1000 alkyl, substituted or unsubstituted, C2-1000 alkenyl, substituted or unsubstituted, C2-1000 alkynyl, substituted or unsubstituted, C1-1000 heteroalkyl, substituted or unsubstituted, C2-1000 heteroalkenyl, substituted or unsubstituted, C2-1000 heteroalkynyl, —ORC, —N(RC)2, —C(═O)RC, —C(═O)ORC, —C(═O)N(RC)2, —NRCC(═O)RC, —NRCC(═O)ORC, —NRCC(═O)N(RC)2, —OC(═O)RC, —OC(═O)ORC, or —OC(═O)N(RC)2;

each instance of RC is independently hydrogen, substituted or unsubstituted, C1-1000 alkyl, substituted or unsubstituted, C2-1000 alkenyl, substituted or unsubstituted, C2-1000 alkynyl, substituted or unsubstituted, C1-1000 heteroalkyl, substituted or unsubstituted, C2-1000 heteroalkenyl, substituted or unsubstituted, C2-1000 heteroalkynyl, a leaving group, an oxygen protecting group when attached to an oxygen atom, a nitrogen protecting group when attached to a nitrogen atom,, each instance of n is independently an integer between 1 and 300, inclusive; and
each instance of RF is independently hydrogen, substituted or unsubstituted, C1-6 alkyl, or an oxygen protecting group; or, is hydrogen or absent, as valency permits.