Patent ID: 11965035
Assignee: KAGOSHIMA UNIVERSITY
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A  G | IPC C  G

Claim 0:
1. An antibody or an antibody fragment thereof which binds to chondroitin sulfate proteoglycan 5 (CSPG5),
wherein the antibody or fragment thereof is selected from the group consisting of the following (a) to (o):
(a) an antibody or fragment thereof in which the amino acid sequences of complementarity determining regions (CDRs) 1 to 3 of a variable domain of a heavy chain (VH) comprise the amino acid sequences represented by SEQ ID NOS: 3, 4, and 5, respectively, and in which the amino acid sequences of CDR1 to CDR3 of a variable domain of a light chain (VL) comprise the amino acid sequences represented by SEQ ID NOS: 8, 9, and 10, respectively;
(b) an antibody or fragment thereof in which the amino acid sequences of CDR1 to CDR3 of VH comprise the amino acid sequences represented by SEQ ID NOS: 13, 14, and 15, respectively, and in which the amino acid sequences of CDR1 to CDR3 of VL comprise the amino acid sequences represented by SEQ ID NOS: 18, 19, and 20, respectively;
(c) an antibody or fragment thereof in which the amino acid sequences of CDR1 to CDR3 of VH comprise the amino acid sequences represented by SEQ ID NOS: 23, 24, and 25, respectively, and in which the amino acid sequences of CDR1 to CDR3 of VL comprise the amino acid sequences represented by SEQ ID NOS: 28, 29, and 30, respectively;
(d) an antibody or fragment thereof in which the amino acid sequences of CDR1 to CDR3 of VH comprise the amino acid sequences represented by SEQ ID NOS: 33, 34, and 35, respectively, and in which the amino acid sequences of CDR1 to CDR3 of VL comprise the amino acid sequences represented by SEQ ID NOS: 38, 39, and 40, respectively;
(e) an antibody or fragment thereof in which the amino acid sequences of CDR1 to CDR3 of VH comprise the amino acid sequences represented by SEQ ID NOS: 43, 44, and 45, respectively, and in which the amino acid sequences of CDR1 to CDR3 of VL comprise the amino acid sequences represented by SEQ ID NOS: 48, 49, and 50, respectively;
(f) an antibody or fragment thereof in which the amino acid sequences of CDR1 to CDR3 of VH comprise the amino acid sequences represented by SEQ ID NOS: 53, 54, and 55, respectively, and in which the amino acid sequences of CDR1 to CDR3 of VL comprise the amino acid sequences represented by SEQ ID NOS: 58, 59, and 60, respectively;
(g) an antibody or fragment thereof in which the amino acid sequences of CDR1 to CDR3 of VH comprise the amino acid sequences represented by SEQ ID NOS: 63, 64, and 65, respectively, and in which the amino acid sequences of CDR1 to CDR3 of VL comprise the amino acid sequences represented by SEQ ID NOS: 68, 69, and 70, respectively;
(h) an antibody or fragment thereof in which the amino acid sequences of CDR1 to CDR3 of VH comprise the amino acid sequences represented by SEQ ID NOS: 73, 74, and 75, respectively, and in which the amino acid sequences of CDR1 to CDR3 of VL comprise the amino acid sequences represented by SEQ ID NOS: 78, 79, and 80, respectively;
(i) an antibody or fragment thereof in which the amino acid sequences of CDR1 to CDR3 of VH comprise the amino acid sequences represented by SEQ ID NOS: 83, 84, and 85, respectively, and in which the amino acid sequences of CDR1 to CDR3 of VL comprise the amino acid sequences represented by SEQ ID NOS: 88, 89, and 90, respectively;
(j) an antibody or fragment thereof in which the amino acid sequences of CDR1 to CDR3 of VH comprise the amino acid sequences represented by SEQ ID NOS: 93, 94, and 95, respectively, and in which the amino acid sequences of CDR1 to CDR3 of VL comprise the amino acid sequences represented by SEQ ID NOS: 98, 99, and 100, respectively;
(k) an antibody or fragment thereof in which the amino acid sequences of CDR1 to CDR3 of VH comprise the amino acid sequences represented by SEQ ID NOS: 103, 104, and, 105, respectively, and in which the amino acid sequences of CDR1 to CDR3 of VL comprise the amino acid sequences represented by SEQ ID NOS: 108, 109, and 110, respectively;
(l) an antibody or fragment thereof in which the amino acid sequences of CDR1 to CDR3 of VH comprise the amino acid sequences represented by SEQ ID NOS: 113, 114, and 115, respectively, and in which the amino acid sequences of CDR1 to CDR3 of VL comprise the amino acid sequences represented by SEQ ID NOS: 118, 119, and 120, respectively;
(m) an antibody or fragment thereof in which the amino acid sequences of CDR1 to CDR3 of VH comprise the amino acid sequences represented by SEQ ID NOS: 123, 124, and 125, respectively, and in which the amino acid sequences of CDR1 to CDR3 of VL comprise the amino acid sequences represented by SEQ ID NOS: 128, 129, and 130, respectively;
(n) an antibody or fragment thereof in which the amino acid sequences of CDR1 to CDR3 of VH comprise the amino acid sequences represented by SEQ ID NOS: 133, 134, and 135, respectively, and in which the amino acid sequences of CDR1 to CDR3 of VL comprise the amino acid sequences represented by SEQ ID NOS: 138, 139, and 140, respectively; and
(o) an antibody or fragment thereof in which the amino acid sequences of CDR1 to CDR3 of VH comprise the amino acid sequences represented by SEQ ID NOS: 143, 144, and 145, respectively, and in which the amino acid sequences of CDR1 to CDR3 of VL comprise the amino acid sequences represented by SEQ ID NOS: 148, 149, and 150, respectively.