Patent ID: 11931478
Assignee: THE UNIVERSITY OF AKRON
Field: Medical technology (Instruments)
Classification: CPC A | IPC A

Claim 0:
1. A method of making a bioactive compound loaded poly(propylene fumarate) tissue scaffold comprising:
a. preparing a 3-D printable resin comprising a poly(propylene fumarate) polymer having alkene functional groups in its polymer chain;
b. forming a poly(propylene fumarate) polymer structure from said 3-D printable resin using 3-D printing technology, wherein said poly(propylene fumarate) polymer structure has a surface with exposed alkene functional groups;
c. preparing a bioactive compound having at least one thiol functional group at or near its terminus selected from the group consisting of basic fibroblast growth factor (bFGF) (CYKRSRYT (SEQ. ID NO. 1)), Bone Morphogenetic Protein 2 (BMP-2) (CKIPKASSVPTELSAISTLYL (SEQ. ID NO. 2), Osteogenic Growth Peptide (OGP), 10-14 (YGFGG) (SEQ. ID NO. 3), BMP-2 73-92 (KIPKASSVPTELSAISTLYL) (SEQ. ID NO. 4), BMP-7 89-117 (TVPKPSSAPTQLNAISTLYF) (SEQ. ID NO. 5), BMP-9 68-87 (KVGKASSVPTKLSPISILYK) (SEQ. ID NO. 6), and combinations thereof;
d. contacting said poly(propylene fumarate) polymer structure with said bioactive compound; wherein the least one thiol functional group on said bioactive compound reacts with the alkene functional groups in the poly(propylene fumarate) polymer chains exposed on the surface of said poly(propylene fumarate) polymer structure, thereby tethering said bioactive compound to said poly(propylene fumarate) polymer structure to form a bioactive compound loaded tissue scaffold.