Patent ID: 11906508
Assignee: AGILENT TECHNOLOGIES, INC.
Field: Measurement (Instruments)
Classification: CPC G | IPC G

Claim 22:
23. A system for continuously monitoring cells in real time, label free, with impedance-based analysis, the system comprising:
a) a well plate comprising a plurality of electrode arrays formed on a nonconductive substrate, wherein each electrode array of the plurality of electrode arrays is disposed in a corresponding well of a plurality of wells defined by the well plate and includes a first electrode structure and a second electrode structure;
b) an impedance analyzer that monitors, in association with individual cell samples in individual wells of the plurality of wells via each individual electrode array of the plurality of electrode arrays, a cell-substrate impedance between the first electrode structure and the second electrode structure across a cell sample disposed in a corresponding well of the plurality of wells;
c) electronic circuitry that electrically connects the plurality of electrode arrays to the impedance analyzer; and
d) a software program that continuously monitors each cell sample via the plurality of cell-substrate impedances across an analysis period of time with measurements recorded at a sampling time resolution during the period of time.