Patent ID: 11963954
Assignee: MEMORIAL SLOAN KETTERING CANCER CENTER
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 16:
17. A compound having a structure represented by a formula:, or a pharmaceutically acceptable salt thereof, wherein
R1a, R1b, and R1c are each independently hydrogen, halogen, —SF5, —NO2, —CH3, —CH2F, —CHF2, —CF3, —OCF3, —NHCH3, —N(CH3)2, —(CH2)-phenyl, —(CH2)-pyridinyl, —(CH2)-pyrimidinyl, —O-phenyl, —O-pyridinyl, or —O-pyrimidinyl, provided that at least one of R1a, R1b, and R1c is not hydrogen; or wherein R1a and R1b are optionally covalently bonded and, together with the intermediate atoms, comprise an optionally substituted 3- to 7-membered fused aryl, heteroaryl, cycloalkyl, cycloalkenyl, heterocycloalkyl, or heterocycloalkenyl; and wherein R1c is hydrogen, halogen, —OH, —SCF3, —SF5, —NO2, —CH3, —CH2F, —CHF2, —CF3, —OCF3, —NHCH3, or —N(CH3)2;
R2 is —(C1-C6 alkyl)-CF3, —(C1-C6 alkyl)-C≡CH, —(C1-C3 alkyl)-cyclopropyl, —(C1-C3 alkyl)-cyclobutyl, —(C1-C3 alkyl)-cyclopentyl, —(C1-C3 alkyl)-cyclohexyl, or —SO2—(C1-C6 alkyl); and wherein R2 is substituted with 0, 1, 2, or 3 groups independently selected from halogen, —OH, —SCF3, —SF5, —NO2, —CH3, —CH2F, —CHF2, —CF3, —OCF3, —NHCH3, and —N(CH3)2; and
R3 is C1-C8 alkyl, C1-C8 alkoxyalkyl, or —(C1-C3 alkyl)-(C3-C8 cycloalkyl).