Patent ID: 11896671
Assignee: ASCENDIS PHARMA A/S
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A

Claim 14:
15. The compound of claim 12, wherein each —Y0 is independently of formula (IV), wherein
the dashed line indicates attachment to -L2- or -L2′-, respectively;
—Ra1 is selected from the group consisting of —COORx1, —ORx1, —C(O)Rx1, —C(O)N(Rx1Rx1a), —S(O)2N(Rx1Rx1a), —S(O)N(Rx1Rx1a), —S(O)2Rx1, —S(O)Rx1, —S(O)2ORx1, —N(Rx1Rx1a), -T0, C1-20 alkyl, C2-20 alkenyl, and C2-20 alkynyl; wherein -T0, C1-20 alkyl, C2-20 alkenyl, and C2-20 alkynyl are optionally substituted with one or more —Rx2, which are the same or different and wherein C1-20 alkyl, C2-20 alkenyl, and C2-20 alkynyl are optionally interrupted by one or more groups selected from the group consisting of -T0-, —C(O)O—, —O—, —C(O)—, —C(O)N(Rx3)—, —S(O)2N(Rx3)—, —S(O)N(Rx3)—, —S(O)2—, —S(O)—, —N(Rx3)S(O)2N(Rx3a)—, —S—, —N(Rx3)—, —OC(ORx3)(Rx3a)—, —N(Rx3)C(O)N(Rx3a)—, and —OC(O)N(Rx3)—;
—Rx1, —Rx1a, —Rx1b are independently of each other selected from the group consisting of —H, -T0, C1-10 alkyl, C2-10 alkenyl, and C2-10 alkynyl; wherein -T0, C1-10 alkyl, C2-10 alkenyl, and C2-10 alkynyl are optionally substituted with one or more —Rx2, which are the same or different and wherein C1-10 alkyl, C2-10 alkenyl, and C2-10 alkynyl are optionally interrupted by one or more groups selected from the group consisting of -T0-, —C(O)O—, —O—, —C(O)—, —C(O)N(Rx3)—, —S(O)2N(Rx3)—, —S(O)N(Rx3)—; —S(O)2—, —S(O)—, —N(Rx3)S(O)2N(Rx3a)—, —S—, —N(Rx3)—, —OC(ORx3)(Rx3a)—, —N(Rx3)C(O)N(Rx3a)—, and —OC(O)N(Rx3)—;
each T0 is independently selected from the group consisting of phenyl, naphthyl, indenyl, indanyl, tetralinyl, C3-10 cycloalkyl, 3- to 10-membered heterocyclyl, and 8- to 11-membered heterobicyclyl; wherein each T0 is independently optionally substituted with one or more —Rx2, which are the same or different;
each —Rx2 is independently selected from the group consisting of halogen, -T0, —CN, oxo(═O), —COORx4, —ORx4, —C(O)Rx4, —C(O)N(Rx4Rx4a), —S(O)2N(Rx4Rx4a), —S(O)N(Rx4Rx4a), —S(O)2Rx4, —S(O)Rx4, —N(Rx4)S(O)2N(Rx4aRx4b), —SRx4, —N(Rx4Rx4a), —NO2, —OC(O)Rx4, —N(Rx4)C(O)Rx4a, —N(Rx4)S(O)2Rx4a, —N(Rx4)S(O)Rx4a, —N(Rx4)C(O)ORx4a, —N(Rx4)C(O)N(Rx4aRx4b), —OC(O)N(Rx4Rx4a), and C1-4 alkyl; wherein C1-4 alkyl is optionally substituted with one or more halogen, which are the same or different;
each —Rx3, —Rx3a, —Rx4, —Rx4a, —Rx4b is independently selected from the group consisting of —H and C1-4 alkyl; wherein C1-4 alkyl is optionally substituted with one or more halogen, which are the same or different.