Patent ID: 11919863
Assignee: BRISTOL-MYERS SQUIBB COMPANY
Field: Organic fine chemistry (Chemistry)
Classification: CPC C | IPC C

Claim 5:
6. The method of claim 1, wherein the compound of formula II, or a stereoisomer thereof, is prepared by
contacting a compound of formula IV:, with a Lewis acid and a hydride source, in a suitable alcoholic organic solvent, for a time and at a temperature sufficient to reduce the carbonyl and to produce a compound of formula V, or a stereoisomer thereof:, , and
contacting the compound of formula V, or a stereoisomer thereof, with X—SO2—R1,
wherein X is halo, or with R1—SO2—O—SO2—R1 in the presence of an alkyl-amine base, in a suitable anhydrous organic solvent, for a time and at a temperature sufficient for X displacement to produce the compound of formula II, or a stereoisomer thereof.