Patent ID: 11859250
Assignee: CHILDREN'S HOSPITAL MEDICAL CENTER
Field: Biotechnology (Chemistry)
Classification: CPC C | IPC C

Claim 14:
15. A method for treating eosinophilic esophagitis (EoE) in a subject in need thereof, the method comprising
subjecting a biological sample from the subject to a method for gene expression analysis,
determining the expression of a panel of genes in the biological sample, the panel comprising ALOX15, APOBEC3A, CDA, and CRISP3,
determining the subject's EoE endotype is mild based on the expression of the panel of genes, wherein a decrease in expression of one or both of ALOX15 and APOBEC3A by at least 2-fold compared to a reference and an increase in expression of one or both of CDA and CRISP3 indicates the subject's EoE endotype is mild,
and
treating the patient with an EoE therapy comprising one or both of proton pump inhibitor (PPI) therapy and dietary therapy.