Patent ID: 11918633
Assignee: BIOMARIN PHARMACEUTICAL INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 15:
16. The method of claim 12, wherein said pegylation is achieved by reacting the AvPAL variant with NETS-activated polyethylene glycol at a ratio of at least 1.6 polyethylene glycol per lysine residue of AvPAL variant, at a ratio of at least 2.4 polyethylene glycol per lysine residue of AvPAL variant, at a ratio of 3 polyethylene glycol per lysine residue of AvPAL variant, at a ratio of 5 polyethylene glycol per lysine residue of AvPAL variant, at a ratio of 6 polyethylene glycol per lysine residue of AvPAL variant, at a ratio of 7 polyethylene glycol per lysine residue of AvPAL variant, at a ratio of 8 polyethylene glycol per lysine residue of AvPAL variant, or at a ratio of 9 polyethylene glycol per lysine residue of AvPAL variant.