Patent ID: 11963950
Assignee: LOXO ONCOLOGY, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 12:
13. The solid formulation according to claim 12, wherein
the diluents or fillers comprise microcrystalline cellulose, powdered cellulose, or mannitol,
the disintegrant comprises starches, calcium carbonate, sodium carbonate, sodium bicarbonate, cellulose and cellulose derivatives, sweeteners, clays, bentonite, alginic acid, sodium alginate, alginates, gums, agar, guar, locust bean, karaya, pectin, tragacanth, citrus pulp, or crospovidone, wherein the cellulose derivatives are selected from the group consisting of calcium carboxymethyl cellulose, microcrystalline cellulose, carboxymethylcellulose calcium, croscarmellose sodium, croscarmellose calcium, carmellose calcium, and cellulose polacrilin potassium and
the dispersing agent is selected from the group consisting of a hydrophilic polymer, an electrolyte, polyethylene glycol sorbitan monostearate, polyoxyethylene sorbitan monooleate, polyvinylpyrrolidone, a hydroxypropyl cellulose, a hydroxypropyl methylcellulose, carboxymethylcellulose sodium, methylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose phthalate, hydroxypropyl methylcellulose acetate succinate (HPMC-AS), noncrystalline cellulose, magnesium aluminum silicate, triethanolamine, polyvinyl alcohol (PVA), vinyl pyrrolidone/vinyl acetate copolymer (S630), tyloxapol, a poloxamine, a poloxamer (polyoxypropylene-polyoxyethylene block copolymers), a polyvinylpyrrolidone, a polyvinylpyrrolidone/vinyl acetate copolymer, polyethylene glycol (PEG), sodium carboxymethylcellulose, sodium alginate, gum tragacanth, gum acacia, guar gum, a xanthan, a sugar, polyethoxylated sorbitan monolaurate, povidone, a carbomer, a chitosan, cellulose, and triethyl cellulose, and combinations thereof.