Patent ID: 11872324
Assignee: THE UNIVERSITY COURT OF THE UNIVERSITY OF GLASGOW
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 13:
14. A method of preparing an implantable construct according to claim 1, comprising the steps of:
(a) depositing an alkyl acrylate polymer on a first surface of a biocompatible substrate to form a material surface wherein the biocompatible substrate is selected from a synthetic polymer, a ceramic, a metal, an alloy and composites thereof and further, wherein the alkyl acrylate polymer is capable of supporting the formation of a physiological fibrillar network of FN adsorbed on its surface; and
(b) applying fibronectin and a growth factor to said material surface to form a biologically active matrix, wherein said growth factor is capable of binding FNIII12-14,
wherein the FN forms a physiological fibrillar network of FN presenting colocalized growth factor binding domains and integrin binding domains;, or the steps of:
(a) providing a biocompatible substrate having a first surface, wherein the biocompatible substrate is selected from a synthetic polymer, a ceramic, a metal, an alloy and composites thereof;
(b) depositing an alkyl acrylate polymer on said first surface to form a material surface; and
(c) applying fibronectin and a growth factor to said material surface to form a biologically active matrix,
wherein the FN forms physiological fibrillar network of FN presenting colocalized growth factor binding domains and integrin binding domains.