Patent ID: 11857633
Assignee: CITY OF HOPE
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 0:
1. A method of treating multiple myeloma in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of a nucleic acid conjugate comprising:
(i) a microRNA selected from the group consisting of let7a-3p miRNA, let7a-5p miRNA, miR17-3p miRNA, miR17-5p miRNA, and miR218-5p miRNA;
(ii) a phosphorothioate polymer selected from the group consisting of:
(a) a single-stranded phosphorothioate deoxyribonucleic acid comprising from 15 to 30 nucleotide residues, and
(b) a single-stranded abasic sugar-phosphorothioated nucleic acid comprising from 15 to 30 nucleotide residues; and

(iii) a chemical linker covalently attaching the phosphorothioate polymer to the 3′ end of the microRNA;
thereby treating the multiple myeloma in the subject.