Patent ID: 11899014
Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
Field: Measurement (Instruments)
Classification: CPC G  C | IPC C  G

Claim 17:
18. A sensor fungal cell comprising a fungal non-native G-protein coupled receptor (GPCR) that binds to a peptide analyte derived from an agent, wherein the peptide analyte is a ligand for the fungal non-native GPCR, wherein binding of the peptide analyte to the fungal non-native GPCR triggers an appearance of a reporter in the fungal cell, wherein the appearance of the reporter indicates the presence of the agent, and wherein the non-native fungal GPCR is an engineered GPCR and comprises an amino acid sequence selected from the group consisting of SEQ ID NOs: 6, 9, 12, 15, 18, 21, 52, 54, 56, 58, 74, 94, and 222.