Patent ID: 11857289
Assignee: WASHINGTON UNIVERSITY
Field: Medical technology (Instruments)
Classification: CPC A  G | IPC A  G

Claim 8:
9. A computer-implemented method of generating at least one optimized functional image of a lesion region of a breast of a subject comprising:
receiving, using a computing device, a plurality of measurements from a diffuse optical tomography (DOT) device, the plurality of measurements comprising lesion functional data from the lesion region of the breast and reference functional data from a healthy tissue region of a contralateral breast;
transforming, using the computing device, the lesion functional data and the reference functional data to produce perturbation data, the perturbation data comprising a normalized difference between the lesion functional data and the reference functional data;
generating, using the computing device, a preliminary estimate of at least one functional image by applying a truncated pseudoinverse matrix of a weight matrix to the perturbation data, the weight matrix comprising a plurality of elements representing system measurement sensitivity of the breast and distribution of diffused optical waves in a homogenous medium;
generating, using the computing device, the at least one optimized functional image by iteratively optimizing successive estimates of the at least one functional image regularized by the preliminary estimate of the at least one functional image weighted by a regularization parameter, wherein a value of the at least one optimized functional image at each voxel in the lesion region is indicative of a hemoglobin concentration at that voxel; and
displaying the at least one optimized functional image on a display device.