Patent ID: 11939380
Assignee: LES LABORATOIRES SERVIER
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A  Y | IPC A  C

Claim 5:
6. A method of enhancing immunity in a human patient in need thereof, comprising administering to the patient an anti-PD-1 antibody or an antigen-binding portion thereof and an anti-TIM-3 antibody or an antigen-binding portion thereof, wherein
I) the anti-PD-1 antibody comprises:
a) heavy chain complementarity-determining regions (H-CDR) 1-3 and light chain complementarity-determining regions (L-CDR) 1-3 comprising the amino acid sequences of SEQ ID NOs: 228-233, respectively;
b) a heavy chain variable domain (VH) and a light chain variable domain (VL) comprising the amino acid sequences of SEQ ID NOs: 226 and 227, respectively; or
c) a heavy chain (HC) and a light chain (LC) comprising the amino acid sequences of SEQ ID NOs: 226 and 375, and SEQ ID NOs: 227 and 379, respectively; and

II) the anti-TIM-3 antibody comprises:
a) H-CDR1-3 and L-CDR1-3 comprising the amino acid sequences of SEQ ID NOs: 8-13, respectively;
b) a VH and a VL comprising the amino acid sequences of SEQ ID NOs: 7 and 4, respectively; or
c) an HC and an LC comprising the amino acid sequences of SEQ ID NOs: 7 and 377; and SEQ ID NOs: 4 and 378; respectively.