Patent ID: 11964281
Assignee: CYTOVALE INC.
Field: Measurement (Instruments)
Classification: CPC B  G | IPC B  G

Claim 0:
1. A method for determining a sepsis condition of a subject comprising:
receiving a dataset generated from a blood sample of the subject, wherein the dataset comprises, for each leukocyte of the blood sample, a plurality of images of the leukocyte as the leukocyte is deformed within a deformation region of a microfluidic channel;
filtering the dataset to exclude images comprising overlapping leukocytes, comprising detecting the overlapping leukocytes based on a monotonicity in feature motion between images of the leukocyte;
determining a biophysical parameter dataset by, for each leukocyte of the blood sample:
determining one or more biophysical parameter associated with the respective leukocyte based on the plurality of images associated with the respective leukocyte;
linearly adjusting the one or more biophysical parameters based on at least one of a flow rate and a path traversed by the respective leukocyte; and

determining a numerical index based on the biophysical parameter dataset; and
based on the numerical index, determining a probability that the subject is experiencing sepsis.