Patent ID: 11952469
Assignee: NATIONAL TAIWAN UNIVERSITY OF SCIENCE AND TECHNOLOGY
Field: Medical technology (Instruments)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A method for preparing a hydrogel composition with thermos-sensitive and ionic reversible properties, comprising following steps:
providing a thermos-sensitive polymer;
providing an anionic polymer comprising polysaccharide having at least one carboxylic acid;
dissolving and mixing the thermos-sensitive polymer and the anionic polymer in a solvent to obtain an initial solution; and
performing a mixing process with the initial solution and an anionic crosslinking agent, wherein when the initial solution and the anionic crosslinking agent are in contact at a temperature over a lower critical solution temperature (LCST), crosslinking occurs to obtain the hydrogel composition with thermos-sensitive and ionic reversible properties, wherein the hydrogel composition with thermos-sensitive and ionic reversible properties has ordered structure in a gel state, and the hydrogel composition with thermos-sensitive and ionic reversible properties can reversibly transfer from the gel state to a solution state,
wherein a weight ratio of the thermos-sensitive polymer and the anionic polymer is 1:0.02-0.12,
wherein when the hydrogel composition contacts a metal chelate aqueous solution having a temperature lower than the LCST of the hydrogel composition, the hydrogel composition transfers from a gel state to a solution state.