Patent ID: 11918650
Assignee: AMGEN INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 11:
12. The method of claim 1, wherein the first binding domain comprises a VH region and a VL region comprising CDR-H1, CDR-H2, CDR-H3, CDR-L1, CDR-L2, and CDR-L3 selected from the group consisting of:
(a) CDR-H1 as set forth in SEQ ID NO: 1, CDR-H2 as set forth in SEQ ID NO: 2, CDR-H3 as set forth in SEQ ID NO: 3, CDR-L1 as set forth in SEQ ID NO: 4, CDR-L2 as set forth in SEQ ID NO: 5 and CDR-L3 as set forth in SEQ ID NO: 6;
(b) CDR-H1 as set forth in SEQ ID NO: 29, CDR-H2 as set forth in SEQ ID NO: 30, CDR-H3 as set forth in SEQ ID NO: 31, CDR-L1 as set forth in SEQ ID NO: 34, CDR-L2 as set forth in SEQ ID NO: 35 and CDR-L3 as set forth in SEQ ID NO: 36;
(c) CDR-H1 as set forth in SEQ ID NO: 42, CDR-H2 as set forth in SEQ ID NO: 43, CDR-H3 as set forth set forth in SEQ ID NO: 44, CDR-L1 as set forth in SEQ ID NO: 45, CDR-L2 as set forth in SEQ ID NO: 46 and CDR-L3 as set forth in SEQ ID NO: 47;
(d) CDR-H1 as set forth in SEQ ID NO: 53, CDR-H2 as set forth in SEQ ID NO: 54, CDR-H3 as set forth in SEQ ID NO: 55, CDR-L1 as set forth in SEQ ID NO: 56, CDR-L2 as set forth in SEQ ID NO: 57 and CDR-L3 as set forth in SEQ ID NO: 58;
(e) CDR-H1 as set forth in SEQ ID NO: 65, CDR-H2 as set forth in SEQ ID NO: 66, CDR-H3 as set forth in SEQ ID NO: 67, CDR-L1 as set forth in SEQ ID NO: 68, CDR-L2 as set forth in SEQ ID NO: 69 and CDR-L3 as set forth in SEQ ID NO: 70;
(f) CDR-H1 as set forth in SEQ ID NO: 83, CDR-H2 as set forth in SEQ ID NO: 84, CDR-H3 as set forth in SEQ ID NO: 85, CDR-L1 as set forth in SEQ ID NO: 86, CDR-L2 as set forth in SEQ ID NO: 87 and CDR-L3 as set forth in SEQ ID NO: 88;
(g) CDR-H1 as set forth in SEQ ID NO: 94, CDR-H2 as set forth in SEQ ID NO: 95, CDR-H3 as set forth in SEQ ID NO: 96, CDR-L1 as set forth in SEQ ID NO: 97, CDR-L2 as set forth in SEQ ID NO: 98 and CDR-L3 as set forth in SEQ ID NO: 99;
(h) CDR-H1 as set forth in SEQ ID NO: 105, CDR-H2 as set forth in SEQ ID NO: 106, CDR-H3 as set forth in SEQ ID NO: 107, CDR-L1 as set forth in SEQ ID NO: 109, CDR-L2 as set forth in SEQ ID NO: 110 and CDR-L3 as set forth in SEQ ID NO: 111;
(i) CDR-H1 as set forth in SEQ ID NO: 115, CDR-H2 as set forth in SEQ ID NO: 116, CDR-H3 as set forth in SEQ ID NO: 117, CDR-L1 as set forth in SEQ ID NO: 118, CDR-L2 as set forth in SEQ ID NO: 119 and CDR-L3 as set forth in SEQ ID NO: 120;
(j) CDR-H1 as set forth in SEQ ID NO: 126, CDR-H2 as set forth in SEQ ID NO: 127, CDR-H3 as set forth in SEQ ID NO: 128, CDR-L1 as set forth in SEQ ID NO: 129, CDR-L2 as set forth in SEQ ID NO: 130 and CDR-L3 as set forth in SEQ ID NO: 131;
(k) CDR-H1 as set forth in SEQ ID NO: 137, CDR-H2 as set forth in SEQ ID NO: 138, CDR-H3 as set forth in SEQ ID NO: 139, CDR-L1 as set forth in SEQ ID NO: 140, CDR-L2 as set forth in SEQ ID NO: 141 and CDR-L3 as set forth in SEQ ID NO: 142;
(l) CDR-H1 as set forth in SEQ ID NO: 152, CDR-H2 as set forth in SEQ ID NO: 153, CDR-H3 as set forth in SEQ ID NO: 154, CDR-L1 as set forth in SEQ ID NO: 155, CDR-L2 as set forth in SEQ ID NO: 156 and CDR-L3 as set forth in SEQ ID NO: 157; and
(m) CDR-H1 as set forth in SEQ ID NO: 167, CDR-H2 as set forth in SEQ ID NO: 168, CDR-H3 as set forth in SEQ ID NO: 169, CDR-L1 as set forth in SEQ ID NO: 170, CDR-L2 as set forth in SEQ ID NO: 171 and CDR-L3 as set forth in SEQ ID NO: 172.