Patent ID: 11926619
Assignee: EISAI R&D MANAGEMENT CO., LTD
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 4:
5. A compound of Formula II:, or a pharmaceutically acceptable salt thereof,
wherein:
X is chosen from O, NR′ groups, and CH2, wherein R′ is chosen from hydrogen and C1-C8 alkyl groups;
R1 is chosen from methyl, groups,, groups, and, groups,
R10 is chosen from C1-C8 alkyl groups, C3-C8 cycloalkyl groups, and halo C1-C8 alkyl groups, wherein the C3-C8 cycloalkyl groups may be unsubstituted or substituted from 1-3 times with a group independently chosen from C1-C8 alkyl groups, hydroxy, halogen groups, and C1-C8 alkoxy groups;
R11 and R12 are each independently chosen from C1-C8 alkyl groups;
one of either R2 or R3 is chosen from hydrogen and C1-C8 alkyl groups, and the other is chosen from hydrogen, hydroxy and C1-C6 alkyl groups;

one of either R4 or R5 is hydrogen, and the other is chosen from hydrogen, hydroxy, and, R6 and R7 are each independently chosen from C1-C8 alkyl groups;
R8 and R9 are each independently chosen from hydrogen and C1-C8 alkyl groups; or Fe and R9 are taken together to form a cyclopropyl ring; and
Y is chosen from C1-C8 alkyl groups, C3-C8 cycloalkyl groups, methoxy, and —NR13R14 groups, wherein R13 and R14 are each independently chosen from hydrogen, C1-C8 alkyl groups, and methoxy C1-C8 alkyl groups; or R13 and R14 may be taken together with the N to form a group chosen from, a morpholine, a piperidine, a thiazolidine, an indole, an indoline, and an isoindoline ring;
wherein Y may be unsubstituted or substituted from 1-3 times with a group independently chosen from C1-C8 alkyl groups, hydroxy, hydroxy C1-C8 alkyl groups, methoxy, methoxy C1-C8 alkyl groups, halo, halo C1-C8 alkyl groups, —C(O)NH2, —NHCOO—C1-C8 alkyl groups, —COOH,, and —NR15R16 groups, wherein R15 and R16 are each independently chosen from hydrogen and C1-C8 alkyl groups.