Patent ID: 11859250
Assignee: CHILDREN'S HOSPITAL MEDICAL CENTER
Field: Biotechnology (Chemistry)
Classification: CPC C | IPC C

Claim 0:
1. A method for treating eosinophilic esophagitis (EoE) in a subject determined to have a severe form of EoE, the method comprising
subjecting a biological sample from the subject to a method for gene expression analysis,
determining the expression of a panel of genes in the biological sample, the panel comprising ACPP, CITED2, CTNNAL1, EML1, FLG, GRPEL2, MT1M, PNLIPRP3, and TSPAN12,
determining the subject's EoE endotype is severe based on the expression of the panel of genes, wherein a decrease in expression of one or more of CTNNAL1, EML1, FLG, PNLIPRP3, and TSPAN12 by at least 2-fold compared to a reference indicates the subject's EoE endotype is severe,
and
treating the patient with an EoE therapy comprising one or more of esophageal dilation, anti-cytokine therapy, and glucocorticoid therapy.