Patent ID: 11958809
Assignee: CYTOKINETICS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A method of preparing omecamtiv mecarbil dihydrochloride hydrate, , comprising:
step (a) admixing methyl 4-(3-amino-2-fluorobenzyl)piperazine-1-carboxylate (Piperazine Aniline), , and phenyl (6-methylpyridin-3-yl)carbamate (Phenyl Carbamate·HCl), , in the presence of diisopropylethylamine and THF to form a solution of omecamtiv mecarbil free base;
step (b) swapping solvent of the solution of omecamtiv mecarbil free base to 2-propanol;
step (c) admixing the solution of omecamtiv mecarbil free base with hydrochloric acid in the presence of water to form omecamtiv mecarbil dihydrochloride hydrate.