Patent ID: 11858943
Assignee: NEUMORA THERAPEUTICS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 1:
2. The method of claim 1, wherein the compound has the structure of Formula (III):, , or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof:
wherein
X is halogen, lower alkyl, lower haloalkyl, lower alkoxy, or cyano;
R1 is hydrogen, lower alkyl-R6, haloalkyl, lower alkoxyalkyl, -cycloalkyl-R6, -alkyl-cycloalkyl-R6, -aryl-R6, -alkyl-aryl-R6, -heterocyclyl-R6, -alkyl-heterocyclyl-R6, lower haloalkyl, -alkyl-C(═O)R3, or —C(═O)R3;
R1b is hydrogen or lower alkyl;
R2 is -Q-(R4)n, —S(═O)2R5, or —C(═O)R5;
R3 lower alkyl, lower haloalkyl, alkoxy, lower haloalkoxy, -cycloalkyl-R6, —O-cycloalkyl-R6, or —O-heterocyclyl-R6;
or R1b and R1 or R1b and R3, together with the atoms to which they are attached, form a ring
Q is aryl or heteroaryl;
each R4 is independently halogen, hydroxy, lower alkyl, lower haloalkyl, lower alkoxy, lower haloalkoxyalkyl, or cyano;
R5 is cycloalkyl, lower alkyl, lower haloalkyl, cycloalkylalkyl, lower alkoxy, lower haloalkoxy, heterocyclyl, or —O-heterocyclyl;
R6 is hydrogen, halo, alkyl, lower haloalkyl, or cyano; and
n is 0, 1, or 2.