Patent ID: 11970495
Assignee: KIND PHARMACEUTICAL
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 8:
9. A compound of Formula I, or an isotopically labeled compound thereof, or an optical isomer thereof, a geometric isomer thereof, a tautomer thereof or a mixture of various isomers, or a pharmaceutically acceptable salt thereof, or a prodrug thereof, wherein the compound is selected from the group consisting of:
(6′-hydroxy-8′-oxo-8′H-spiro[cyclopropane-1,5′-indolizine]-7′-carbonyl)glycine;
(6′-hydroxy-8′-oxo-8′H-spiro[cyclopropane-1,5′-indolizine]-7′-carbonyl)-L-alanine;
(6′-hydroxy-8′-oxo-8′H-spiro[cyclopropane-1,5′-indolizine]-7′-carbonyl)-D-alanine;
(6-hydroxy-5,5-dimethyl-8-oxo-5,8-dihydroindolizin-7-carbonyl)glycine;
(6-hydroxy-5,5-dimethyl-8-oxo-5,8-dihydroindolizin-7-carbonyl)-L-alanine;
(6′-hydroxy-8′-oxo-8′H-spiro[cyclobutane-1,5′-indolizine]-7′-carbonyl)glycine;
(6′-hydroxy-8′-oxo-8′H-spiro[cyclobutane-1,5′-indolizine]-7′-carbonyl)-L-alanine;
(6′-hydroxy-8′-oxo-8′H-spiro[cyclopentane-1,5′-indolizine]-7′-carbonyl)glycine;
(6′-Hydroxy-8′-oxo-8′H-spiro[cyclopentane-1,5′-indolizine]-7′-carbonyl)glycine methyl ester;
(6′-Hydroxy-8′-oxo-8′H-spiro[cyclopentane-1,5′-indolizine]-7′-carbonyl)glycine ethyl ester;
(6′-hydroxy-8′-oxo-8′H-spiro[cyclopentane-1,5′-indolizine]-7′-carbonyl)-L-alanine;
(6′-hydroxy-8′-oxo-8′H-spiro[cyclopentane-1,5′-indolizine]-7′-carbonyl)-D-alanine;
(6′-hydroxy-8′-oxo-8′H-spiro[cyclohexane-1,5′-indolizine]-7′-carbonyl)glycine;
(6′-hydroxy-8′-oxo-8′H-spiro[cyclohexane-1,5′-indolizine]-7′-carbonyl)-L-alanine;
(6′-hydroxy-8′-oxo-8′H-spiro[cyclopentane-1,5′-indolizine]-7′-carbonyl)-L-alanine ethyl ester;
(((6′-hydroxy-8′-oxo-8′H-spiro[cyclohexane-1,5′-indolizine]-7′-carbonyl)glycyloxy)) methyl pivalate;
(6-hydroxy-8-oxo-2′,3′,5′,6′-tetrahydro-8H-spiro[indolizin-5,4′-pyran]-7-carbonyl)glycine;
(6′-hydroxy-8′-oxo-8′H-spiro[cyclohexane-1,5′-indolizine]-7′-carbonyl)glycine ethyl ester;
(6′-hydroxy-8′-oxo-8′H-spiro[cycloheptane-1,5′-indolizine]-7′-carbonyl)glycine;
((1,4-trans)-6′-hydroxy-4-methyl-8′-oxo-8′H-spiro[cyclohexane-1,5′-indolizine]-7′-carbonyl)glycine; and
((1,4-cis)-6′-hydroxy-4-methyl-8′-oxo-8′H-spiro[cyclohexane-1,5′-indolizine]-7′-carbonyl)glycine.