Patent ID: 11945822
Assignee: QURIENT CO., LTD.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 3:
4. The compound according to claim 1, having the general formula III, wherein X, L1, R1, R2 and Z are as defined in claim 1, and
Q1 is either absent or independently, at each occurrence, selected from the group consisting of aryl optionally substituted with one or two of C1-C6 alkyl, —OR5, —N(R5)R5, and halogen;
heteroaryl optionally substituted with one or two of C1-C6 alkyl, —OR5, —N(R5)R5 and halogen;
and heterocyclyl optionally substituted with one or two of R29 and R30;
R29 is either absent or independently, at each occurrence, selected from the group consisting of hydrogen, —OR5, halogen, —N(R5)R5, —NR9R12, —NH(C═O)R5, —(C═O)NH2, aryl, heteroaryl, heterocyclyl, and C1-C6 alkyl optionally substituted with —OH or —NH2;
R30 is, independently, at each occurrence, selected from the group consisting of hydrogen, halogen, —OR5, —N(R5)R5, (═O), aryl, heteroaryl, heterocyclyl, and C1-C6 alkyl optionally substituted with —OH or —NH2;
wherein R5, R9 and R12 are as defined in claim 1;
L2 is either absent or independently, at each occurrence, selected from the group consisting of —O—, —NH—, —(C═O)— and —(C═O)NH—;
Y1 is, independently at each occurrence, selected from CH, C(OH) and N;
Y2 is, independently at each occurrence, selected from CH, CR30, O and N;
m is, independently at each occurrence, selected from 0, 1 and 2;
n is, independently at each occurrence, selected from 0 and 1;
wherein, if R1 is H, R2 is CH(CH3)2, L1 is absent, Q1 is absent, L2 is absent, Y1 is N, Y2 is CH, m is 1, n is 1, R29 is N(R5)R5, R30 is H, R5 is H, X is N, Z is phenyl, R7 is H, R8 is H, R9 is H and R10 is H, then R6 is not 1H-pyrazole;
wherein, if R1 is H, R2 is CH(CH3)2, L1 is O, Q1 is absent, L2 is absent, Y1 is CH, Y2 is N, m is 1, n is 1, R29 is CH3, R30 is H, X is N, Z is phenyl, R7 is H, R8 is H, R9 is H and R10 is H, then R6 is not 1H-pyrazole;
wherein, if R1 is H, R2 is CH(CH3)2, L1 is —(C═O)—, Q1 is absent, L2 is absent, Y′ is N, Y2 is N, m is 1, n is 1, R30 is H, X is N, Z is phenyl, R6 is 1H-pyrazole, R7 is H, R8 is H, R9 is H and R10 is H, then R29 is not H;
wherein, if R1 is H, R2 is CH(CH3)2, L1 is —(C═O)—, Q1 is absent, L2 is absent, Y1 is N, Y2 is CH, m is 1, n is 1, R29 is N(R5)R5, R30 is H, R5 is H, R30 is H, X is N, Z is phenyl, R7 is H, R8 is H, R9 is H and R10 is H, then R6 is not 1H-pyrazole;
wherein, if R1 is H, R2 is CH(CH3)2, L1 is O, Q1 is absent, L2 is absent, Y1 is CH, Y2 is N, m is 1, n is 1, R29 is H, R30 is H, X is N, Z is phenyl, R7 is H, R8 is H, R9 is H and R10 is H, then R6 is not 1H-pyrazole;
wherein, if R1 is H, R2 is CH(CH3)2, L1 is O, Q1 is absent, L2 is absent, Y1 is CH, Y2 is N, m is 1, n is 0, R29 is H, R30 is H, X is N, Z is phenyl, R7 is H, R8 is H, R9 is H and R10 is H, then R6 is not 1H-pyrazole;
wherein, if R1 is H, R2 is CH(CH3)2, L1 is O, Q1 is absent, L2 is absent, Y1 is CH, Y2 is CH, m is 1, n is 1, R29 is N(R5)R5, R30 is H, R5 is H, X is N, Z is phenyl, R7 is H, R8 is H, R9 is H and R10 is H, then R6 is not 1H-pyrazole;
wherein, if R1 is H, R2 is CH(CH3)2, L1 is NH, Q1 is absent, L2 is absent, Y1 is CH, Y2 is N, m is 1, n is 0, R29 is H, R30 is H, X is N, Z is phenyl, R7 is H, R8 is H, R9 is H and R10 is H, then R6 is not 1H-pyrazole;
wherein, if R1 is H, R2 is CH(CH3)2, L1 is absent, Q1 is absent, L2 is absent, Y1 is N, Y2 is CH, m is 1, n is 0, R29 is N(R5)R5, R30 is H, R5 is H, X is N, Z is phenyl, R7 is H, R8 is H, R9 is H and R10 is H, then R6 is not 1H-pyrazole;
wherein, if R1 is H, R2 is CH(CH3)2, L1 is NH, Q1 is absent, L2 is absent, Y1 is CH, Y2 is CH, m is 1, n is 1, R29 is N(R5)R5, R30 is H, R5 is H, X is N, Z is phenyl, R7 is H, R8 is H, R9 is H and R10 is H, then R6 is not 1H-pyrazole;
wherein, if R1 is H, R2 is CH(CH3)2, L1 is absent, Q1 is absent, L2 is absent, Y1 is N, Y2 is CH, m is 2, n is 0, R29 is N(R5)R5, R30 is H, R5 is H, X is N, Z is phenyl, R7 is H, R8 is H, R9 is H and R10 is H, then R6 is not 1H-pyrazole;
wherein, if R1 is H, R2 is CH(CH3)2, L1 is O, Q1 is absent, L2 is absent, V is CH, Y2 is N, m is 2, n is 0, R29 is H, R30 is H, X is N, Z is phenyl, R7 is H, R8 is H, R9 is H and R10 is F, then R6 is not 1H-pyrazole;
wherein, if R1 is H, R2 is CH(CH3)2, L1 is O, Q1 is absent, L2 is absent, Y1 is CH, Y2 is N, m is 1, n is 1, R29 is CH3, R30 is H, X is N, Z is phenyl, R7 is H, R8 is H, R9 is H and R10 is H, then R6 is not 1H-pyrazole;
wherein, if R1 is CH3, R2 is CH(CH3)2, L1 is O, Q1 is absent, L2 is absent, Y1 is CH, Y2 is N, m is 2, n is 0, R29 is H, R30 is H, X is N, Z is phenyl, R7 is H, R8 is H, R9 is H and R10 is H, then R6 is not 1H-pyrazole;
or an enantiomer, stereoisomeric form, mixture of enantiomers, diastereomer, mixture of diastereomers, racemate of the above compounds, or a pharmaceutically acceptable salt thereof.