Patent ID: 11935626
Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Field: Computer technology (Electrical engineering)
Classification: CPC G  C | IPC C  G

Claim 0:
1. A method for haplotype phasing, the method comprising:
providing a cell comprising chromosomes;
crosslinking DNA within the chromosomes to form crosslinked DNA;
fragmenting the crosslinked DNA to form fragmented crosslinked DNA;
ligating two regions of the fragmented crosslinked DNA that are in close physical proximity to create ligated DNA comprising a ligation product, wherein the two regions comprise an intra-chromosomal pair;
shearing the ligated DNA to generate a plurality of smaller genomic fragments;
sequencing the plurality of smaller genomic fragments to generate sequencing reads;
identifying at least one heterozygous site in the sequencing reads; and
using the sequencing reads to determine haplotype phasing of the at least one heterozygous site.