Patent ID: 11866471
Assignee: TORO MIYAZAKI
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A mutant human apoptosis inhibitor of macrophage (AIM) comprising an amino acid sequence of any one of the following (a) to (d) and having an activity of wild-type human AIM:
(a) an amino acid sequence wherein cysteine at amino acid number 168 of the amino acid sequence shown in SEQ ID NO: 1 is substituted with another amino acid,
(b) an amino acid sequence wherein cysteine at amino acid number 277 of the amino acid sequence shown in SEQ ID NO: 1 is substituted with another amino acid,
(c) an amino acid sequence wherein cysteine at amino acid number 168 of the amino acid sequence shown in SEQ ID NO: 1 is substituted with another amino acid, and an amino acid sequence wherein cysteine at amino acid number 277 of the amino acid sequence shown in SEQ ID NO: 1 is substituted with another amino acid,
(d) an amino acid sequence further comprising deletion, addition, insertion or substitution of one to 5 amino acids or a combination thereof at a position other than the cysteines present in the amino acid sequence of any one of (a) to (c) and the substituted another amino acid of any one of (a) to (c).