Patent ID: 11858916
Assignee: PFIZER INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC C

Claim 0:
1. A compound of Formula I:, or a pharmaceutically acceptable salt thereof, wherein A is A1 or A2,, and wherein
each R1 is independently halogen, —CN, —C1-3alkyl, or —OC1-3alkyl, wherein the alkyl of C1-3alkyl and OC1-3alkyl is substituted with 0 to 3 F atoms;
m is 0, 1, 2, or 3;
X—L is N—CH2, CHCH2, or cyclopropyl;
Y is CH or N;
ZA1 is CH, CR2, or N;
ZA2 is CH, CR2, or N;
ZA3 is CH, CR2, or N, provided that ZA2 and ZA3 are not simultaneously N; and further provided that one of ZA2 and ZA3 is N when X—L is N—CH2;
each R2 is independently F, C, or —CN;
each R3 is independently F, —OH, —CN, —C1-3alkyl, —OC1-3alkyl, or —C3-4cycloalkyl, or 2 R3s may together cyclize to form —C3-4spirocycloalkyl, wherein the alkyl of C1-3alkyl and OC1-3alkyl, cycloalkyl, or spirocycloalkyl may be substituted as valency allows with 0 to 3 F atoms and with 0 to 1 —OH;
q is 0, 1, or 2;
R4 is —C1-3alkyl, —C0-3alkylene-C3-9cycloalkyl, —C0-3alkylene-R5, or —C1-3alkylene-R6, wherein said alkyl may be substituted as valency allows with 0 to 3 substituents independently selected from 0 to 3 F atoms and 0 to 1 substituent selected from —C0-1alkylene-CN, —C0-1alkylene-ORO, and —N(RN)2, and

wherein said alkylene of —C0-3alkylene-C3-6cycloalkyl, —C0-3alkylene-R5, or —C1-3alkylene-R6 and said cycloalkyl may be independently substituted as valency allows with 0 to 2 substituents independently selected from 0 to 2 F atoms and 0 to 1 substituent selected from C0-1alkylene-CN, C0-1alkylene-ORO, and —N(RN)2;
R5 is a 4- to 6-membered heterocycloalkyl, wherein said heterocycloalkyl may be substituted with 0 to 2 substituents as valency allows independently selected from:
0 to 1 oxo (═O),
0 to 1 —CN,
0 to 2 F atoms, and
0 to 2 substituents independently selected from —C1-3alkyl and —OC1-3alkyl, wherein the alkyl of C1-3alkyl and OC1-3alkyl may be substituted with 0 to 3 substituents as valency allows independently selected from:
0 to 3 F atoms,
0 to 1 —CN, and
0 to 1 —ORO;

R6 is a 5- to 6-membered heteroaryl, wherein said heteroaryl may be substituted with 0 to 2 substituents as valency allows independently selected from:
0 to 2 halogens,
0 to 1 substituent selected from —ORO and —N(RN)2, and
0 to 2 —C1-3alkyl, wherein the alkyl may be substituted with 0 to 3 substituents as valency allows independently selected from:
0 to 3 F atoms, and
0 to 1 —ORO;

each RO is independently H, or —C1-3alkyl, wherein C1-3alkyl may be substituted with 0 to 3 F atoms;
each RN is independently H, or —C1-3alkyl;
Z1, Z2, and Z3 are each —CRZ, or
one of Z1, Z2, and Z3 is N and the other two are —CRZ; and
each RZ is independently H, F, Cl, or —CH3.