Patent ID: 11912996
Assignee: DICERNA PHARMACEUTICALS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC C

Claim 0:
1. A method of treating a lung disease or disorder, the method comprising introducing into cells of a human a double stranded nucleic acid (dsNA), wherein said human has a mutation in one or both copies of the α-1 antitrypsin gene, wherein said dsNA comprises a first nucleic acid strand and a second nucleic acid strand that each have a nucleotide sequence consisting of 21 nucleotides, wherein said first nucleic acid strand consists of the nucleic acid sequence of SEQ ID NO:1908, wherein said second nucleic acid strand is 100% complementary to SEQ ID NO: 1908, and wherein said dsNA reduces α-1 antitrypsin target mRNA expression when introduced into said cells of said human.