Patent ID: 11903638
Assignee: BIOSENSE WEBSTER (ISRAEL) LTD.
Field: Medical technology (Instruments)
Classification: CPC A | IPC A

Claim 7:
8. A method for ablating tissue within a body of a patient, the method comprising:
inserting a probe into the body, wherein the probe comprises a plurality of electrodes configured to contact the tissue;
providing an electrical signal generator configured to apply bipolar trains of pulses between at least one pair of the plurality of electrodes, each bipolar pulse having a voltage amplitude of at least 200 V and a duration less than 20 μs between at least one pair of the plurality of electrodes in contact with the tissue, thereby causing irreversible electroporation (IRE) of the tissue between the at least one pair of the plurality of electrodes;
determining, based on IRE setup parameters, a target value of dissipated electrical energy to be transferred to the tissue from trains of the bipolar trains of pulses applied to the tissue in contact with the at least one pair of electrodes;
causing electrical and temporal parameters of the trains of the bipolar trains of pulses to be transmitted to the electrical signal generator;
measuring a dissipated electrical energy between the at least one pair of the electrodes from the trains of the bipolar trains of pulses, which is to be transferred to the tissue during the trains of the bipolar trains of pulses, by computing a sum of a product of a voltage and a current flowing between the at least one pair of electrodes over a sequence of time intervals, the voltage and current being measured by one or more electrical sensors coupled to an output of the electrical signal generator;
determining, continuously, whether the measured dissipated electrical energy that is to be transferred to the tissue in contact with the least one pair of electrodes during IRE is equal to or exceeds the target value;
causing the IRE to be terminated when the measured dissipated electrical energy that is to be transferred to the tissue is equal to or exceeds the target value;
determining, when the measured dissipated electrical energy that is to be transferred to the tissue is less than the target value, a predicted total dissipated energy to be transferred to the tissue based upon the electrical and temporal parameters;
comparing the predicted total dissipated electrical energy to the target value;
causing the electrical and temporal parameters to be modified when the predicted total dissipated energy is less than the target value; and
causing the IRE to be terminated when the measured dissipated electrical energy that is to be transferred to the tissue equals the target value.