Patent ID: 11878161
Assignee: LEONHARDT VENTURES LLC
Field: Medical technology (Instruments)
Classification: CPC A | IPC A

Claim 18:
19. A method of upregulating expression of COL17A1 in living target tissue to stimulate the living target tissue to produce collagen XVII, the method comprising:
applying at least one bioelectric signal that upregulates expression of COL17A1 in the living target tissue,
wherein the at least one bioelectric signal to upregulate expression of COL17A1 is a biphasic, square-wave pulse with a 50% duty cycle having a frequency of
25 Hz (+/−20 Hz) or
5,000 Hz

at 10 mV to 100 mV as may be measured in the living target tissue,
so as to stimulate the living target tissue to upregulate expression of COL17A1 and thus produce collagen XVII in the living target tissue.