Patent ID: 11952398
Assignee: KM BIOLOGICS CO., LTD.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A method for purifying blood coagulation factor VII (Factor VII) and activated blood coagulation factor VII (activated Factor VII) from cryoprecipitate-poor plasma-derived fraction, comprising the following steps:
(a) applying cryoprecipitate-poor plasma-derived fraction to a first strong anion exchange resin;
(b) adsorbing Factor VII and activated Factor VII from the cryoprecipitate-poor plasma-derived fraction to the first strong anion exchange resin and recovering a non-adsorbed fraction;
(c) adsorbing Factor VII and activated Factor VII which remains in the non-adsorbed fraction in step (b) to a second strong anion exchange resin; and
(d) recovering Factor VII and activated Factor VII from first and second strong anion exchange resins in steps (b) and (c), by elution wherein recovering Factor VII and activated Factor VII from the first strong anion exchange resin and second strong anion exchange resin occurs simultaneously.