Patent ID: 11905291
Assignee: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
Field: nan (nan)
Classification: CPC nan | IPC C

Claim 7:
8. A method of treating a WD40 repeat domain protein 5 (WDR5)-mediated disease, comprising administering to a subject with a WDR5-mediated disease, a bivalent compound comprising a WDR5 ligand conjugated to a degradation/disruption tag through a linker, wherein said disease is selected from the group consisting of leukemia, lymphoma, ovarian cancer, stomach cancer, cervical cancer, uterine cancer, gastric cancer, head neck squamous cell carcinoma (HNSCC), colorectal cancer (CRC), lung cancer, pancreatic cancer, bladder cancer, breast cancer, and neuroblastoma.