Patent ID: 11857598
Assignee: UNIVERSITY OF SOUTH FLORIDA
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 8:
9. A pharmaceutical formulation comprising:
at least one RNA molecule of interest (ROI), wherein the at least one ROI encodes a protein selected from the group consisting of BAX, B18R, PTEN, p16, P15, P18, P19, P21, P57, CDKN3, MS2, p65, HSF1, and p27;
a microRNA (miRNA) target sequence, wherein the miRNA target sequence is a target for miR-126, miR-122, miR-208, miR-145, or miR-143, and combinations thereof, and wherein the miRNA target sequence is operatively linked to the at least one ROI;
a RNA molecule capable of being translated into a viral RNA replicase, wherein the RNA molecule capable of being translated into a viral RNA replicase is operatively linked to the at least one ROI, the miRNA target sequence, or both the at least one ROI and miRNA target sequence; and
a pharmaceutically acceptable carrier.