Patent ID: 11952411
Assignee: JANSSEN BIOTECH, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 12:
13. The method of claim 12, further comprising a step of generating a multimeric engineered TL1A ligand, wherein optionally:
(i) the multimeric engineered TL1A ligand comprises:
a. the non-covalent TL1A trimer and one or more Fc regions;
b. the non-covalent TL1A trimer and one or more HSA regions;
c. the scTL1A trimer and one or more Fc regions; or
d. the scTL1A trimer and one or more HSA regions, or

(ii) the multimeric engineered TL1A ligand comprises:
a. two non-covalent TL1A trimers and three Fc regions;
b. two scTL1A trimers and one Fc region;
c. one scTL1A trimer and one Fc region;
d. one non-covalent TL1A trimer and three HSA regions; or
e. one scTL1A trimer and one HSA region.