Patent ID: 11921102
Assignee: CORNING INCORPORATED
Field: Measurement (Instruments)
Classification: CPC G  C | IPC C  G

Claim 0:
1. A cell culture monitoring system configured to non-invasively monitor a cell culture, the system comprising:
a cell culture vessel comprising a plurality of cell culture chambers in a stacked arrangement, each of the plurality of cell culture chambers having a surface on which cells are cultured;
at least one monitoring layer in the stacked arrangement of the plurality of cell culture chambers, the at least one monitoring layer comprising an outer wall surrounding a monitoring layer cell culture chamber within the stacked arrangement of the plurality of cell culture chambers and having at least one surface to which cells adhere, the at least one monitoring layer comprising at least one indentation in the outer wall; and
at least one monitoring module disposed in the at least one indentation in the outer wall, the monitoring module comprising:
an illumination system configured to emit light into at least one of the cell culture chambers;
an imaging system configured to image contents of the at least one cell culture chamber that are illuminated by the illumination system,
wherein the illumination system and the imaging system are on a same side of the monitoring module;

wherein the at least one monitoring module is configured to monitor a cell culture chamber of a cell culture layer positioned both above and below the at least one monitoring layer, and wherein the at least one indentation in the outer wall is on a sidewall of the outer wall.