Patent ID: 11912751
Assignee: GLOBETEK SCIENCE FOUNDATION
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A fusion protein comprising (i) a Transforming Growth Factor—Beta (TGF-B) ligand, wherein the TGF-B consists of TGF-B1 (SEQ ID NO: 14), linked by a rigid peptide linker (SEQ ID NO: 27) to (ii) an immune checkpoint ligand, wherein the immune checkpoint ligand consists of PD-L1 (SEQ ID NO: 17); and wherein the TGF-B1 ligand and immune checkpoint PD-L1 ligands are capable of binding to TGF-B receptors and immune checkpoint receptors, respectively, that are expressed in human and animal cells.