Patent ID: 11970785
Assignee: BASE PAIR BIOTECHNOLOGIES, INC.
Field: Biotechnology (Chemistry)
Classification: CPC C | IPC C

Claim 0:
1. A method for utilizing a nucleic acid array comprising:
providing a substrate with a plurality of single-stranded nucleic acid ligands located and attached at predetermined addresses on said substrate, each of said single-stranded nucleic acid ligands being an aptamer binding to a known target molecule with an identical hybridization sequence for each of said single-stranded nucleic acid ligands at one of said predetermined addresses, and forming a hybridization to a single-stranded nucleic acid label, each comprising a complementary hybridization sequence to said hybridization sequence;
incubating said substrate with a sample which may potentially contain at least one target molecule which binds to at least one of said plurality of single-stranded nucleic acid ligands; and
determining if any changes in said hybridizations occur after said incubating by performing a detection operation to detect potential changes in said hybridizations between said single-stranded nucleic acid labels and said single-stranded nucleic acid ligands correlated to said addresses;, wherein said potential changes in said hybridizations indicate binding of said at least one target molecule to at least one of said plurality of single-stranded nucleic acid ligands when a change in said hybridization occurs after adding said sample and no change in said hybridization after adding said sample indicates no binding of said at least one target molecule to any of said plurality of single-stranded nucleic acid ligands.