Patent ID: 11859214
Assignee: THE GOVERNMENT OF THE UNITED STATES, AS REPRESENTED BY THE SECRETARY OF THE ARMY
Field: Measurement (Instruments)
Classification: CPC C  G | IPC C  G

Claim 8:
9. The in vitro model of an in vivo gastrointestinal tract according to claim 7, wherein each of the first fermentation vessel, the second fermentation vessel, the third fermentation vessel, the fourth fermentation vessel, the fifth fermentation vessel and the sixth fermentation vessel further including a pH sensor configured to determine the pH of contents of the respective fermentation vessel and each of the second fermentation vessel, the third fermentation vessel, the fourth fermentation vessel, the fifth fermentation vessel and the sixth fermentation vessel including
a source of acid in fluid communication with each fermentation vessel and configured to supply acid thereto;
a source of base in fluid communication with each fermentation vessel configured to supply base thereto; and, said controller configured to:
receive signals from the pH sensor indicating the pH of the contents of each fermentation vessel;
for the first fermentation vessel, selectively at least one of start, stop and regulate the flow through the first pump to add bile acids to lower the pH of contents of the first fermentation vessel or selectively start or regulate the flow through the second pump to add sodium bicarbonate to raise the pH of contents of the first fermentation vessel;
for each of the second fermentation vessel, the third fermentation vessel, the fourth fermentation vessel, the fifth fermentation vessel and the sixth fermentation vessel, selectively add acid to lower the pH of contents of each fermentation vessel or selectively add base to raise the pH of contents of the first fermentation vessel each fermentation vessel.