Patent ID: 11970538
Assignee: COMPASS THERAPEUTICS LLC
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 8:
9. An antibody or antigen-binding fragment thereof that binds a PD-1 ligand and comprises:
(a) a heavy chain variable region comprising (i) a CDRH1 comprising the amino acid sequence of SEQ ID NO: 1; (ii) a CDRH2 comprising the amino acid sequence of SEQ ID NO: 2 (GGIIPX1X2GX3ATYA, wherein X1 is V or I; X2 is F, L, or V; and X3 is T or A); and (iii) a CDRH3 comprising the amino acid sequence of SEQ ID NO: 3 (ARLKX1ELKDAFDI, wherein X1 is G, F, or N); and
(b) a light chain variable region comprising: (i) a CDRL1 comprising the amino acid sequence of SEQ ID NO: 4 (RASQX1ISSYLN, wherein X1 is S, W, or Q); (ii) a CDRL2 comprising the amino acid sequence of SEQ ID NO: 5; and (iii) a CDRL3 comprising the amino acid sequence of SEQ ID NO: 6 (X1QSYSTPLT, wherein X1 is Q or F).