Patent ID: 11883631
Assignee: THE UNIVERSITY OF BRITISH COLUMBIA
Field: Medical technology (Instruments)
Classification: CPC A  G | IPC A  G

Claim 14:
15. A method for implementing closed loop controlled administration of at least one drug to a patient, the method comprising:
providing a drug administration actuator for administration of the at least one drug to the patient at a controllable drug dosage rate;
sensing one or more physiological characteristics of the patient and determining therefrom a monitor measurement indicative of an effect of the at least one drug on the patient; and
for each of a series of time steps, determining a control signal and supplying the control signal to the drug administration actuator to thereby cause the drug administration actuator to administer the at least one drug to the patient at a drug dosage rate which causes the monitor measurement to track a reference level;
wherein determining the control signal comprises implementing a closed loop model-predictive control scheme which comprises, for each of the series of time steps, minimizing a cost function (performance index) subject to one or more constraints to thereby determine the control signal, the cost function based at least in part on the reference level and the monitor measurement;
wherein determining the control signal comprises using the control signal as an input to an auxiliary model and using the auxiliary model and the control signal to estimate at least one concentration level of the at least one drug in the patient; and
wherein the one or more constraints comprise at least one constraint on the estimate of the at least one concentration level of the at least one drug.