Patent ID: 11911532
Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
Field: Macromolecular chemistry, polymers (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 0:
1. A reversible thermal gel polymer formulation, comprising:
(a) reversible thermal gel polymers, wherein each of the polymers independently comprise:
a first polymer block comprising first repeating units, wherein each of the first repeating units of the first polymer block independently comprise a hydrophilic group; and
a second polymer block comprising second repeating units, wherein each of the second repeating units of the second polymer block independently comprise a thermosensitive group; wherein:
the first polymer block and the second polymer block are directly or indirectly covalently linked;
wherein:
each of the polymers is independently is characterized by the formula (FX4):, Y is selected from the group consisting of —OH, a radiopaque group, and a targeting ligand;
L3, if present, is selected from the group consisting of a single bond, —(CH2)q—, —(HCCH)q—, —(CH2CH2X)q—, —(CHXH)q—, —X—, —NR5—, —CX—, —CXX—, —XCX—, —XCX(CH2)qCXX—, —CXNR5—, —NR5CX—, —XCXNR5—, —NR5CXX—, —CX(CH2)qCR5CN—, —(CH2)qX(CH2)r—, —(CH2)qXX(CH2)r, —(CH2)qNR5(CH2)r—, —(CH2)qCX(CH2)r—, —(CH2)qCXX(CH2)r—, —(CH2)qCXNR5(CH2)r—, —(CH2)qNR5CX(CH2)r—, —(CH2)qXCXNR5(CH2)r—, and —(CH2)qNR5CXNR6(CH2)r—;
X is O or S;
W2, if present, is selected from the group consisting of a single bond, —(CH2)q—, —(HCCH)q—, —(CH2CH2X)q—, —(CHXH)q—, —X—, —CXX—, —XCX—, —CX—, —XCX(CH2)qCXX—, and —NR11—;
W2, if present, is selected from the group consisting of a single bond, —(CH2)q—, —(HCCH)q—, —(CH2CH2X)q—, —(CHXH)q—, —X—, —CXX—, —XCX, —CX—, —XCX(CH2)qCXX—, and —NR11—;
each of R1, R2, R3, and R4 is independently selected from the group consisting of hydrogen, halide, and C1-C5 alkyl;
each of a, b and c is independently 0 or 1;
each of q and r is an integer independently selected from the range of 1 to 10:
z is an integer selected from the range of 0 to 4;
m is an integer selected from the range of 1 to 10,000;
n is an integer selected from the range of 1 to 1,000;
p is an integer selected from the range of 1 to 1,000; and
each of R5, R6 and R11 is independently selected from the group consisting of hydrogen, C1-C10 alkyl, C5-C10 aryl, and C5-C10 heteroaryl;
and

(b) a solvent;
wherein said reversible thermal gel polymers are dissolved in said solvent and have a concentration in the solvent selected from the range of 2% to 50% w/v; and
wherein the polymer formulation is characterized by a viscosity less than or equal to 1,500 cP.