Patent ID: 11859180
Assignee: IONIS PHARMACEUTICALS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A method of reducing the turbidity, viscosity, or both viscosity and turbidity of an antisense oligonucleotide solution, said method comprising adding at least one excipient to an antisense oligonucleotide solution having an antisense oligonucleotide present at a concentration of 100-500 mg/ml wherein the antisense oligonucleotide comprises a modified oligonucleotide comprising at least one modified nucleoside, and wherein the viscosity and/or turbidity of the antisense oligonucleotide solution containing the excipient(s) is less than the viscosity and/or turbidity of the antisense oligonucleotide solution that does not contain the excipient(s).