Patent ID: 11866514
Assignee: GENMAB A/S
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A  G | IPC A  C  G

Claim 13:
14. A heterodimeric antibody obtained or obtainable by a method comprising the following steps:
a) providing a first nucleic acid construct encoding a first chimeric, humanized, or human heavy chain comprising a first Fc region, said first Fc region comprising a CH3 region of human IgG4,
b) providing a second nucleic acid construct encoding a second chimeric, humanized, or human heavy chain comprising a second Fc region, said second Fc region comprising a CH3 region of human IgG4 comprising amino acid substitutions at positions 405 and 409, wherein the numbering is according to the EU Index,
c) co-expressing said first and second nucleic acid constructs in a host cell, and
d) obtaining said heterodimeric antibody from the cell culture.