Patent ID: 11969517
Assignee: DREXEL UNIVERSITY
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 0:
1. A method of treating a chronic wound comprising:
(a) sequentially administering IL-4 to the wound from a delivery system, wherein the IL-4 induces conversion of a first population of wound macrophages in the wound to M2A macrophages; and then
(b) sequentially administering IL-10 to the wound from the delivery system, wherein the IL-10 induces conversion of a second population of wound macrophages to M2C macrophages,
wherein the sequential conversion of the wound macrophages promotes tissue remodeling,
wherein steps (a) and (b) are sequentially performed by the delivery system;
wherein the delivery system is a sequential controlled release delivery system; and
further wherein the sequential controlled release delivery system is an affinity-based delivery system.