Patent ID: 11919990
Assignee: HENKEL AG & CO. KGAA
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 19:
20. A process for making a transdermal device comprising a silicone-acrylic hybrid pressure sensitive adhesive (PSA) composition and an active in a one-pot process comprising the steps of.
(a) making an acrylic polymer by a polymerization reaction of (i) a mixture of monomers, wherein at least one monomer comprises a hydrolyzable silane (meth)acrylic monomer and/or a siloxane (meth)acrylic macromer, (ii) a radical initiator; (iii) an organic solvent, and
(b) adding (i) a silicone polymer and (ii) a base or an acid catalyst into the acrylic polymer solution (a) and reacting at a temperature of about 50 to about 150° C. for about 2 to about 24 hours to form a silicone-acrylic hybrid solution;
(c) neutralizing the solution (b) at a temperature of about room temperature to about 150° C. for about 2 to 24 hours;
(d) removing any solid precipitates to form a single-phase silicone-acrylic hybrid PSA composition;
(e) adding the active to the solution (d), wherein the active is a pharmaceutical, nutraceutical and/or cosmeceutical agent;
(f) applying the solution (e) onto a film substrate; and
(g) evaporating the solvent to form a transdermal device
wherein the one-pot process is conducted in a single reaction setting; and
wherein the silicon-acrylic hybrid pressure sensitive adhesive composition remains as a single-phase for over six months.