Patent ID: 11883464
Assignee: STAIDSON (BEIJING) BIOPHARMACEUTICALS CO., LTD.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 0:
1. A nerve growth factor fusion protein, comprising a general formula A-B or A-L-B, wherein:
A is a human nerve growth factor,
L is a linker peptide, and
B is an Fc moiety of IgG1, a mutant of the Fc moiety of IgG1, or a fragment of the Fc moiety of IgG1, wherein the mutant of the Fc moiety comprises a site mutation associated with antibody dependent cell-mediated cytotoxicity (ADCC)/complement dependent cytotoxicity (CDC) activity, or a deglycosylation mutation;
wherein the human nerve growth factor comprises F12E with reference to the amino acid position set forth in mature wild-type human nerve growth factor.