Patent ID: 11964023
Assignee: MERCK SHARP & DOHME LLC
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 19:
20. The method of claim 1, wherein x is from 0.7 to 1.0; wherein the carrier protein is conjugated to the polysaccharide through the carbon 2 position of a glycerol-1-PO4 sugar; wherein the degree of conjugation of the conjugate is between 3-13; wherein the polysaccharide has a molecular weight of between 100 and 300 kDa; wherein the mass ratio of polysaccharide to carrier protein in the conjugate is between 0.5 and 1.5; and wherein the polysaccharide-carrier protein conjugate comprises less than about 15% of non-covalently associated polysaccharide compared to the total amount of polysaccharide.