Patent ID: 11897891
Assignee: INCYTE CORPORATION
Field: Organic fine chemistry (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 39:
40. The compound of claim 1, wherein the compound is selected from:
(S)-1-(3-(4-(2-(2-Chloro-6-(trifluoromethyl)phenyl)-3-methylimidazo[2,1-f][1,6]naphthyridin-9-yl)-1H-pyrazol-1-yl)pyrrolidin-1-yl)-2-hydroxyethan-1-one;
(S)-1-(3-(4-(2-(2,6-Dimethylphenyl)-3-methylimidazo[2,1-f][1,6]naphthyridin-9-yl)-1H-pyrazol-1-yl)pyrrolidin-1-yl)-2-hydroxyethan-1-one;
(S)-3-Fluoro-2-(9-(1-(1-(2-hydroxyacetyl)pyrrolidin-3-yl)-1H-pyrazol-4-yl)-3-methylimidazo[2,1-f][1,6]naphthyridin-2-yl)benzonitrile;
(S)-1-(3-(4-(2-(2-Fluoro-6-methoxyphenyl)-3-methylimidazo[2,1-f][1,6]naphthyridin-9-yl)-1H-pyrazol-1-yl)pyrrolidin-1-yl)-2-hydroxyethan-1-one;
2-(2,3-Dimethylphenyl)-3-methyl-9-(1-methyl-1H-pyrazol-4-yl)imidazo[2,1-f][1,6]naphthyridine;
(3-Methyl-4-(3-methyl-9-(1-methyl-1H-pyrazol-4-yl)imidazo[2,1-f][1,6]naphthyridin-2-yl)phenyl)methanol;
2-(2,6-Dichlorophenyl)-3-methyl-9-(1-methyl-1H-pyrazol-4-yl)imidazo[2,1-f][1,6]naphthyridin-8-ol;
(S)-2-(2,6-Dichlorophenyl)-3-methyl-9-(1-methyl-1H-pyrazol-4-yl)-10-((tetrahydrofuran-3-yl)oxy)imidazo[2,1-f][1,6]naphthyridine;
2-(2,6-Dichlorophenyl)-N,N,3-trimethyl-9-(1-methyl-1H-pyrazol-4-yl)imidazo[2,1-f][1,6]naphthyridin-8-amine;
N-(2,4-Dichloro-3-(3-methyl-9-(1-methyl-1H-pyrazol-4-yl)imidazo[2,1 f][1,6]naphthyridin-2-yl)phenyl)acrylamide;
N-(3-(3-Methyl-9-(1-methyl-1H-pyrazol-4-yl)imidazo[2,1-f][1,6]naphthyridin-2-yl)phenyl)acrylamide;
N-(2-(3-Methyl-9-(1-methyl-1H-pyrazol-4-yl)imidazo[2,1-f][1,6]naphthyridin-2-yl)phenyl)acrylamide;
(1-Aminocyclopropyl)(3-(4-(2-(2,6-dichlorophenyl)-3-methylimidazo[2,1 f][1,6]naphthyridin-9-yl)-1H-pyrazol-1-yl)azetidin-1-yl)methanone;
1-(3-(4-(2-(2,6-Dichlorophenyl)-3-methylimidazo[2,1-f][1,6]naphthyridin-9-yl)-1H-pyrazol-1-yl)azetidin-1-yl)-2-(1H-imidazol-1-yl)ethan-1-one;
(3-(4-(2-(2,6-Dichlorophenyl)-3-methylimidazo[2,1-f][1,6]naphthyridin-9-yl)-1H-pyrazol-1-yl)azetidin-1-yl)(oxazol-4-yl)methanone;
(4-Aminotetrahydro-2H-pyran-4-yl)(3-(4-(2-(2,6-dichlorophenyl)-3-methylimidazo[2,1-f][1,6]naphthyridin-9-yl)-1H-pyrazol-1-yl)azetidin-1-yl)methanone;
3-(3-(4-(2-(2,6-Dichlorophenyl)-3-methylimidazo[2,1-f][1,6]naphthyridin-9-yl)-1H-pyrazol-1-yl)azetidin-1-yl)-3-oxopropanenitrile;
4-((4-(2-(2,6-Dichlorophenyl)imidazo[2,1-f][1,6]naphthyridin-9-yl)-1H-pyrazol-1-yl)methyl)-2-fluorobenzoic acid;
4-(4-(2-(2,6-Dichlorophenyl)imidazo[2,1-f][1,6]naphthyridin-9-yl)-1H-pyrazol-1-yl)-N,N-dimethylbenzamide;
N-((1r,4r)-4-(4-(2-(2,6-Dichlorophenyl)imidazo[2,1-f][1,6]naphthyridin-9-yl)-1H-pyrazol-1-yl)cyclohexyl)-2-methoxyacetamide;
3-((1r,4r)-4-(4-(2-(2,6-Dichlorophenyl)imidazo[2,1-f][1,6]naphthyridin-9-yl)-1H-pyrazol-1-yl)cyclohexyl)-1,1-dimethylurea;
1-(7-(4-(2-(2,6-Dichlorophenyl)imidazo[2,1-f][1,6]naphthyridin-9-yl)-1H-pyrazol-1-yl)-2-azaspiro[3.5]nonan-2-yl)ethan-1-one
2-(2,6-Dichlorophenyl)-3-methyl-9-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)imidazo[2,1-f][1,6]naphthyridine;
(1r,4r)-4-(4-(2-(2,6-Dichlorophenyl)-3-methylimidazo[2,1-f][1,6]naphthyridin-9-yl)-1H-pyrazol-1-yl)cyclohexan-1-ol;
4-(4-(2-(2,6-Dichlorophenyl)-3-methylimidazo[2,1-f][1,6]naphthyridin-9-yl)-1H-pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
3-(4-(2-(2,6-Dichlorophenyl)imidazo[2,1-f][1,6]naphthyridin-9-yl)-1H-pyrazol-1-yl)-N,N-dimethylpyrrolidine-1-carboxamide;
3-(4-(2-(2,6-Dichlorophenyl)imidazo[2,1-f][1,6]naphthyridin-9-yl)-1H-pyrazol-1-yl)-N,N-dimethylpyrrolidine-1-sulfonamide;
(S)-1-(3-(4-(2-(2,6-Dichlorophenyl)-3-methylimidazo[2,1-f][1,6]naphthyridin-9-yl)-1H-pyrazol-1-yl)pyrrolidin-1-yl)ethan-1-one;
(S)-1-(3-(4-(2-(2,6-Dichlorophenyl)-3-methylimidazo[2,1-f][1,6]naphthyridin-9-yl)-1H-pyrazol-1-yl)pyrrolidin-1-yl)-2-hydroxyethan-1-one;
1-(1-(4-(2-(2,6-Dichlorophenyl)-3-methylimidazo[2,1-f][1,6]naphthyridin-9-yl)-1H-pyrazol-1-yl)-3-azabicyclo[3.1.0]hexan-3-yl)-2-hydroxyethan-1-one;
(S)-1-(3-(4-(2-(2,6-Dichlorophenyl)-3-(hydroxymethyl)imidazo[2,1-f][1,6]naphthyridin-9-yl)-1H-pyrazol-1-yl)pyrrolidin-1-yl)-2-hydroxyethan-1-one;
(S)-1-(3-(4-(2-(2,6-Dichlorophenyl)-3-(hydroxymethyl)imidazo[2,1-f][1,6]naphthyridin-9-yl)-1H-pyrazol-1-yl)pyrrolidin-1-yl)ethan-1-one;
(S)-(3-(4-(2-(2,6-Dichlorophenyl)-3-(hydroxymethyl)imidazo[2,1-f][1,6]naphthyridin-9-yl)-1H-pyrazol-1-yl)pyrrolidin-1-yl)(morpholino)methanone;
1-((3S)-3-(4-(2-(2,6-dichlorophenyl)-3-(1-hydroxyethyl)imidazo[2,1-f][1,6]naphthyridin-9-yl)-1H-pyrazol-1-yl)pyrrolidin-1-yl)-2-hydroxyethan-1-one;
1-(6-(4-(2-(2,6-Dichlorophenyl)-3-methylimidazo[2,1-f][1,6]naphthyridin-9-yl)-1H-pyrazol-1-yl)-3-azabicyclo[4.1.0]heptan-3-yl)-2-hydroxyethan-1-one;
1-(1-(4-(2-(2,6-Dichlorophenyl)-3-methylimidazo[2,1-f][1,6]naphthyridin-9-yl)-1H-pyrazol-1-yl)-3-azabicyclo[4.1.0]heptan-3-yl)ethan-1-one;
1-(3-(5-(2-(2,6-Dichlorophenyl)-3-methylimidazo[2,1-f][1,6]naphthyridin-9-yl)pyridin-2-yl)azetidin-1-yl)-2-hydroxyethan-1-one;
1-(3-(5-(2-(2,6-Dichlorophenyl)-3-methylimidazo[2,1-f][1,6]naphthyridin-9-yl)pyridin-3-yl)azetidin-1-yl)ethan-1-one;
1-(3-(5-(2-(2,6-Dichlorophenyl)-3-methylimidazo[2,1-f][1,6]naphthyridin-9-yl)phenyl)azetidin-1-yl)ethan-1-one;
(S)-1-(3-(4-(2-(2-Chlorophenyl)-3-(hydroxymethyl)imidazo[2,1-f][1,6]naphthyridin-9-yl)-1H-pyrazol-1-yl)pyrrolidin-1-yl)ethan-1-one;
(S)-1-(3-(4-(2-(2-Chlorophenyl)-3-isopropylimidazo[2,1-f][1,6]naphthyridin-9-yl)-1H-pyrazol-1-yl)pyrrolidin-1-yl)-2-hydroxyethan-1-one;
(S)-1-(3-(4-(3-Bromo-2-(2-chloro-6-fluorophenyl)imidazo[2,1-f][1,6]naphthyridin-9-yl)-1H-pyrazol-1-yl)pyrrolidin-1-yl)-2-hydroxyethan-1-one;
2-Cyclopropyl-3-methyl-9-(1-methyl-1H-pyrazol-4-yl)imidazo[2,1-j][1,6]naphthyridine;
(2-(2,6-Dichlorophenyl)-9-(1-methyl-1H-pyrazol-4-yl)imidazo[2,1-f][1,6]naphthyridin-3-yl)methanol;
(9-(1-Cyclopropyl-1H-pyrazol-4-yl)-2-(2,6-dichlorophenyl)imidazo[2,1-f][1,6]naphthyridin-3-yl)methanol;
(2-(2,6-Dichlorophenyl)-9-(1-(tetrahydrofuran-3-yl)-1H-pyrazol-4-yl)imidazo[2,1-f][1,6]naphthyridin-3-yl)methanol;
(2-(2,6-Dichlorophenyl)-9-(1-(oxetan-3-yl)-1H-pyrazol-4-yl)imidazo[2,1-f][1,6]naphthyridin-3-yl)methanol;
(2-(2,6-Dichlorophenyl)-9-(1-(2-(dimethylamino)ethyl)-1H-pyrazol-4-yl)imidazo[2,1-f][1,6]naphthyridin-3-yl)methanol;
(2-(2,6-Dichlorophenyl)-9-(1-isopropyl-1H-pyrazol-4-yl)imidazo[2,1-f][1,6]naphthyridin-3-yl)methanol;
(2-(2,6-Dichlorophenyl)-9-(1-(difluoromethyl)-1H-pyrazol-4-yl)imidazo[2,1-f][1,6]naphthyridin-3-yl)methanol;
3-(4-(2-(2,6-Dichlorophenyl)-3-(hydroxymethyl)imidazo[2,1-f][1,6]naphthyridin-9-yl)-1H-pyrazol-1-yl)propanenitrile;
1-(4-(2-(2,6-Dichlorophenyl)-3-(hydroxymethyl)imidazo[2,1-f][1,6]naphthyridin-9-yl)-1H-pyrazol-1-yl)-2-methylpropan-2-ol;
2-(4-(2-(2,6-Dichlorophenyl)-3-(hydroxymethyl)imidazo[2,1-f][1,6]naphthyridin-9-yl)-1H-pyrazol-1-yl)acetonitrile;
(2-(2,6-Dichlorophenyl)-9-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)imidazo[2,1-f][1,6]naphthyridin-3-yl)methanol;
2-(4-(2-(2,6-Dichlorophenyl)-3-(hydroxymethyl)imidazo[2,1-f][1,6]naphthyridin-9-yl)-1H-pyrazol-1-yl)-2-methylpropan-1-ol;
(2-(2,6-Dichlorophenyl)-9-(1-(2-(methylsulfonyl)ethyl)-1H-pyrazol-4-yl)imidazo[2,1-f][1,6]naphthyridin-3-yl)methanol;
(2-(2,6-Dichlorophenyl)-9-(1-(2,2,2-trifluoroethyl)-1H-pyrazol-4-yl)imidazo[2,1-f][1,6]naphthyridin-3-yl)methanol;
(2-(2,6-Dichlorophenyl)-9-(1-(2-morpholinoethyl)-1H-pyrazol-4-yl)imidazo[2,1-f][1,6]naphthyridin-3-yl)methanol; and
2-(4-(2-(2,6-Dichlorophenyl)-3-(hydroxymethyl)imidazo[2,1-f][1,6]naphthyridin-9-yl)-1H-pyrazol-1-yl)ethan-1-ol,
or a pharmaceutically acceptable salt of any of the aforementioned.