Patent ID: 11872225
Assignee: AGIOS PHARMACEUTICALS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 1:
2. The method of claim 1, wherein:
Q is hydrogen, optionally substituted —C1-C6 alkyl, optionally substituted C3-C12 cycloalkyl, optionally substituted 3- to 14-membered heterocyclyl, optionally substituted 6- to 14-membered aryl, or optionally substituted 5- to 14-membered heteroaryl;
R1 is hydrogen, optionally substituted —C1-C6 alkyl, optionally substituted —C1-C6 haloalkyl, optionally substituted —C2-C6 alkenyl, optionally substituted —C2-C6 alkynyl, optionally substituted C3-C12 cycloalkyl, optionally substituted 3- to 14-membered heterocyclyl, optionally substituted 6- to 12-membered aryl, —ORo1, —C(═O)Rc1, or a nitrogen protecting group;
L1 is a bond, optionally substituted C1-6 alkylene, —O—, —S—, —S—CH2—, —S(═O)CH2—, —S(═O)2CH2—, —NR—, —NR3C(═O)—, —C(═O)NR3—, C(═O)—, —OC(═O)—, —C(═O)O—, —NR3C(═O)O—, —OC(═O)NR3—, —NR3C(═O)NR3—, —OC(R4)2—, —C(R4)2O—, —NR3C(R4)2—,—C(R4)2NR3—, —S(═O)2—, —S(═O)—, —S(═O)2O—, —OS(═O)2—, —S(═O)O—, —OS(═O)—, —S(═O)2NR3—, —NR3S(═O)2—, —S(═O)NR3—, —NR3S(═O)—, —NR3S(═O)2O—, —OS(═O)2NR3—, —NR3S(═O)O—, —OS(═O)NR3—, or —S(═O)(═NR3)—, wherein the point of the attachment to R2 is on the left-hand side;
L2 is a bond, optionally substituted C1-C6 alkylene, —C(═O)—, —S(═O)2—, or —S(═O)—wherein the point of the attachment to Q is on the right-hand side;
R2 is hydrogen, halogen, optionally substituted —C1-C6 alkyl, optionally substituted —C1-C6 alkoxy, optionally substituted —C3-C12 cycloalkyl, optionally substituted 3- to 14-membered heterocyclyl, optionally substituted —C6-C12 aryl, or optionally substituted 3- to 14-membered heteroaryl, or a nitrogen protecting group when L1 is —NR—, —NR3C(═O)—, —NR3C(═O)O—, —NR3C(R4)2—, —NR3S(═O)2—, —NR3S(═O)—, —NR3C(═O)NR3—, —NR3S(═O)2O—, or —NR3S(═O)O—, an oxygen protecting group when L1 is —O—, —OC(═O)—, —OC(═O)NR3—, —OC(R4)2—, —OS(═O)—, —OS(═O)2—, —OS(═O)2NR3—, —OS(═O)NR3—, or —OS(═O)—, or a sulfur protecting group when L1 is —S—;
each instance of R3 is independently hydrogen, —ORo2, optionally substituted —C1-C6 alkyl, optionally substituted —C2-C6 alkenyl, optionally substituted —C2-C6 alkynyl, optionally substituted C3-C12 cycloalkyl, optionally substituted C3-C12 heterocyclyl, optionally substituted C6-C12 aryl, optionally substituted C5-C12 heteroaryl, or a nitrogen protecting group;
each instance of Ro1 and Ro2 is independently hydrogen, optionally substituted —C1-C6alkyl, or an oxygen protecting group;
each instance of Rcn is independently optionally substituted —C1-C6 alkyl or —N(Rcn)2, wherein each instance of Rcn is independently hydrogen, —C1-C6 alkyl, or a nitrogen protecting group;
each instance of R4 is independently hydrogen, optionally substituted —C1-C6 alkyl, optionally substituted —C2-C6 alkenyl, optionally substituted —C2-C6 alkynyl, optionally substituted C3-C12 cycloalkyl, optionally substituted 3- to 14-membered heterocyclyl, optionally substituted C6-C12 aryl, or optionally substituted 5- to 14-membered heteroaryl.