Patent ID: 11896591
Assignee: UNIVERSITY OF VIRGINIA PATENT FOUNDATION
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 0:
1. A compound or pharmaceutically acceptable salt thereof, wherein the compound is
N5-(2-fluorophenyl)-N6-(pyridin-2-yl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine (4b);
N5-(2-fluorophenyl)-N6-(3-fluorophenyl)-[1,2,]oxadiazolo[3,4-b]pyrazine-5,6-diamine (4c);
N5-(2,3-difluorophenyl)-N6-(2-fluorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine (4e);
N5-(2,4-difluorophenyl)-N6-(2-fluorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine (4f);
N5-(2-fluorophenyl)-N6-(o-tolyl)[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine (4g);
N5-(2-fluorophenyl)-N6-(m-tolyl)[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine (4h);
N5-(2-fluorophenyl)-N6-(3-methoxyphenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine (4k);
N5-(2-fluorophenyl)-N6-(4-methoxyphenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine (4l);
N5-(2-ethoxyphenyl)-N6-(2-fluorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine (4m);
N5-(3-ethoxyphenyl)-N6-(2-fluorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine (4n);
N5-(4-ethoxyphenyl)-N6-(2-fluorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine (4o);
3-((6-(2-fluorophenyl)amino)-[1,2,5]oxadiazolo[3,4-b]pyrazin-5-yl)amino)phenol (4p);
N5-(2-fluorophenyl)-N6-(2-(trifluoromethoxy)phenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine (4q);
N5-(2-fluorophenyl)-N6-(3-(trifluoromethoxy)phenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine (4r);
N5-(2-fluorophenyl)-N6-(4-(trifluoromethoxy)phenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine (4s);
2,2,2-Trifluoro-N-(4-((6-(2-fluorophenyl)amino)-[1,2,5]oxadiazolo[3,4-b]pyrazin-5-yl)amino)phenyl)acetamide (4t);
N5-(2-fluorophenyl)-N6-(2-(trifluoromethyl)phenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine (4u);
N5-(2-fluorophenyl)-N6-(3-(trifluoromethyl)phenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine (4v);
N5-(2-fluorophenyl)-N6-(4-(trifluoromethyl)phenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine (4w);
Methyl 4-((6-((2-fluorophenyl)amino)-[1,2,5]oxadiazolo[3,4-b]pyrazin-5-yl)amino)benzoate (4y);
4-Fluoro-3-((6-((2-fluorophenyl)amino)-[1,2,5]oxadiazolo[3,4-b]pyrazin-5-yl)amino)phenol (4z);
N5-(3,5-bis(trifluoromethyl)phenyl)-N6-(2-fluorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine (4aa);
N5-(2-fluoro-3-(trifluoromethyl)phenyl)-N6-(2-fluorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine (4bb);
N5-(2-fluorophenyl)-N6-methyl[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine (7a);
N5-ethyl-N6-(2-fluorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine (7b);
N5-(2-fluorophenyl)-N6-propyl[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine (7c);
N5-(2-fluorophenyl)-N6-(3,3,3-trifluoropropyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine (7d);
N5-(2-fluorophenyl)-N6-(1-methylpiperidin-4-yl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine (7e); or
N5-cyclohexyl-N6-(2-fluorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine (7f).