Patent ID: 11866684
Assignee: DOC MEDIKUS GMBH
Field: Biotechnology (Chemistry)
Classification: CPC C  G | IPC C  G

Claim 0:
1. A method for concurrent micro-positron emission tomography (micro-PET) or micro-single photon emission computed tomography (micro-SPECT) of at least two cell cultures in a biocompatible column,
the column comprising an inlet, an axially oriented perfusion chamber and an outlet, wherein the inlet is fluidly connected to the perfusion chamber and the outlet is fluidly connected to the perfusion chamber, wherein the perfusion chamber comprises a porous solid phase, an aqueous liquid phase, a first cell culture and a second cell culture, wherein at least a portion of the first cell culture and at least a portion of the second cell culture are in contact with the solid phase and wherein the first cell culture is separated from the second cell culture by at least a portion of the solid phase;
the method comprising the steps of:
(A) inserting the column into a micro-PET or micro-SPECT scanner;
(B) conducting an aqueous labelling liquid comprising a radioactive tracer via the inlet through the perfusion chamber towards the outlet, such that at least a portion of the cells of the first cell culture and at least a portion of the cells of the second cell culture are contacted with the radioactive tracer;
(C) conducting an aqueous washing liquid via the inlet through the perfusion chamber towards the outlet, such that at least a portion of the radioactive tracer is removed from the perfusion chamber through the outlet; and
(D) scanning the column with the micro-PET or micro-SPECT scanner.