Patent ID: 11911479
Assignee: nan
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 0:
1. A method for making a crosslinked composition, the method comprising:
forming a mixture comprising:
a glycosaminoglycan comprising a plurality of thiol groups and having a thiol modification of about 0.1 to about 0.4 μmol thiol per mg of glycosaminoglycan, and
a molecule comprising poly(ethylene glycol) having at least two thiol-reactive sites, wherein the molar ratio of the thiol groups to the thiol reactive sites in the mixture is at least 2:1 ; and

crosslinking the glycosaminoglycan and the poly(ethylene glycol) at a pH between about 3.2 and about 5.0,
wherein the crosslinked composition comprises about 0.05 to about 0.2 μmol uncrosslinked thiol groups per mg of the glycosaminoglycan.