Patent ID: 11871895
Assignee: THE JOHNS HOPKINS UNIVERSITY
Field: Measurement (Instruments)
Classification: CPC A  G  B | IPC A  B  G

Claim 13:
14. A method of determining a location of a therapeutic agent on a cell, tissue, and/or organ, the method comprising:
a) providing a SERS nanoplex of claim 1;
b) applying the nanoplex to a cell, tissue, and/or organ so that the nanoplex binds to the cell, tissue, and/or organ;
c) exciting the nanoplex with an energy source to create a Raman signal;
d) detecting the Raman signal; and
e) constructing an image from the Raman signal to determine the location of the therapeutic agent on the cell, tissue, and/or organ, wherein the therapeutic agent is selected from an ester-urea based and Glu-urea-Lys-linker based PSMA binding agent, PSMA targeted phosphoramidate and phosphonate, 7E11 monoclonal antibody, J591 monoclonal antibody, 3C6 monoclonal antibody, 177Lu, and 90Y.