Patent ID: 11913898
Assignee: ASCENSIA DIABETES CARE HOLDINGS AG
Field: Measurement (Instruments)
Classification: CPC G | IPC G

Claim 0:
1. A method of operating a biosensor system for determining signal-based anchor parameters, the method comprising:
providing a biosensor system comprising:
a measurement device having electrical circuitry communicatively coupled to a processor, a storage medium, a signal generator, and a sensor interface, the processor having instructions and data stored in the storage medium, and a test sensor having a base and a sample interface, the base forming a reservoir and a channel with an opening, the reservoir being in electrical or optical communication with the measurement device;

measuring, one or more analyte responsive output signals from a reference sample, wherein the one or more analyte responsive output signals are indicative of an effect of one or more extraneous stimuli on the reference sample,
determining a normalizing relationship based on linear or non-linear regression of the one or more analyte responsive output signals;
storing the normalizing relationship in the storage medium, wherein the normalizing relationship is stored as part of calibration information used for calibrating the biosensor system to account for the one or more extraneous stimuli;
responsive to receiving a biological fluid sample, applying an electrical or optical input signal to generate an input signal from the signal generator;
generating at least one analyte responsive output signal, wherein the one or more analyte responsive output signals is an electrical output signal generated by a redox reaction or a light-generated output signal in response to a light-identifiable species;
determining an initial analyte concentration of the biological fluid sample based on the at least one analyte responsive output signal;
determining, using the normalizing relationship, at least one normalized output signal from the at least one analyte responsive output signal;
determining, a pseudo-reference concentration value of the biological fluid sample,
wherein the pseudo-reference concentration value is a substitute for true relative error;
determining at least one corresponding normalized output signal by selecting at least one reference sample analyte concentration from a plurality of stored reference sample analyte concentration and a normalized reference correlation;
determining a system error for the at least one analyte responsive output signal through a comparison of the initial analyte concentration and the at least one reference sample analyte concentration,
wherein the system error contributes to inaccurate analyte concentration determinations;
responsive to determining the system error, determining at least one signal-based anchor parameter based on a comparison of the pseudo-reference concentration value and the at least one corresponding normalized output signal, wherein the at least one signal-based anchor parameter compensates for the system error;
incorporating the at least one signal-based anchor parameter into a compensation relationship, wherein the compensation relationship compensates for inaccuracies caused by the system error;
determining a final compensated analyte concentration of the biological fluid sample based at least in part on the compensation relationship and the initial analyte concentration of the biological fluid sample; and
outputting the final compensated analyte concentration to one or more of a display, a remote receiver, or a storage medium.