Patent ID: 11867700
Assignee: THE TRUSTEES OF INDIANA UNIVERSITY
Field: Measurement (Instruments)
Classification: CPC G  H | IPC G  H

Claim 7:
8. A method of measuring lipoprotein particles in at least one subpopulation of a subtype of a density class of intact lipoprotein particles present in a sample containing the density class, or the subtype of the density class, of intact lipoprotein particles, the method comprising:
a) producing lipoprotein ions from the density class, or the subtype of the density class, of intact lipoprotein particles contained in the sample,
b) simultaneously measuring a charge and a mass-to-charge ratio of each of the lipoprotein ions,
c) determining a mass of each of the lipoprotein ions based on the measured charge and mass-to-charge ratio values thereof,
d) identifying the at least one subpopulation of the subtype of the density class of intact lipoprotein particles based on the determined masses and measured charges of the lipoprotein ions, and
e) determining diameters of lipoprotein particles in the identified at least one subpopulation based on the determined masses and known densities of the lipoprotein particles in the identified at least one subpopulation.