Patent ID: 11919953
Assignee: AMGEN INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A  Y | IPC A  C

Claim 7:
8. The TIGIT antigen-binding protein of claim 7, comprising (I) a HC variable region and LC variable comprising the amino acid sequences are selected from the group consisting of: (a) SEQ ID NOs: 111-112, respectively; (b) SEQ ID NOs: 121-122, respectively; (c) SEQ ID NOs: 131-132, respectively; (d) SEQ ID NOs: 141-142, respectively; (e) SEQ ID NOs: 151-152, respectively; (f) SEQ ID NOs: 161-162, respectively; (g) SEQ ID NOs: 171-172, respectively; (h) SEQ ID NOs: 181-182, respectively; (i) SEQ ID NOs: 191-192, respectively; (j) SEQ ID NOs: 201-202, respectively; (k) SEQ ID NOs: 211-212, respectively; (l) SEQ ID NOs: 221-222, respectively; and (m) SEQ ID NOs: 2011-2012, respectively or (II) a HC variable region comprising an amino acid sequence having at least 90% sequence identity to SEQ ID NO: 111 and a LC variable region comprising an amino acid sequence having at least 90% sequence identity to SEQ ID NO: 112; (b) a HC variable region comprising an amino acid sequence having at least 90% sequence identity to SEQ ID NO: 121 and a LC variable region comprising an amino acid sequence having at least 90% sequence identity to SEQ ID NO: 122; (c) a HC variable region comprising an amino acid sequence having at least 90% sequence identity to SEQ ID NO: 131 and a LC variable region comprising an amino acid sequence having at least 90% sequence identity to SEQ ID NO: 132; (d) a HC variable region comprising an amino acid sequence having at least 90% sequence identity to SEQ ID NO: 141 and a LC variable region comprising an amino acid sequence having at least 90% sequence identity to SEQ ID NO: 142, (e) a HC variable region comprising an amino acid sequence having at least 90% sequence identity to SEQ ID NO: 151 and a LC variable region comprising an amino acid sequence having at least 90% sequence identity to SEQ ID NO: 152; (f) a HC variable region comprising an amino acid sequence having at least 90% sequence identity to SEQ ID NO: 161 and a LC variable region comprising an amino acid sequence having at least 90% sequence identity to SEQ ID NO: 162; (g) a HC variable region comprising an amino acid sequence having at least 90% sequence identity to SEQ ID NO: 171 and a LC variable region comprising an amino acid sequence having at least 90% sequence identity to SEQ ID NO: 172; (h) a HC variable region comprising an amino acid sequence having at least 90% sequence identity to SEQ ID NO: 181 and a LC variable region comprising an amino acid sequence having at least 90% sequence identity to SEQ ID NO: 182; (i) a HC variable region comprising an amino acid sequence having at least 90% sequence identity to SEQ ID NO: 191 and a LC variable region comprising an amino acid sequence having at least 90% sequence identity to SEQ ID NO: 192; (j) a HC variable region comprising an amino acid sequence having at least 90% sequence identity to SEQ ID NO: 201 and a LC variable region comprising an amino acid sequence having at least 90% sequence identity to SEQ ID NO: 202; (k) a HC variable region comprising an amino acid sequence having at least 90% sequence identity to SEQ ID NO: 211 and a LC variable region comprising an amino acid sequence having at least 90% sequence identity to SEQ ID NO: 212; (l) a HC variable region comprising an amino acid sequence having at least 90% sequence identity to SEQ ID NO: 221 and a LC variable region comprising an amino acid sequence having at least 90% sequence identity to SEQ ID NO: 222; (m) a HC variable region comprising an amino acid sequence having at least 90% sequence identity to SEQ ID NO: 2011 and a LC variable region comprising an amino acid sequence having at least 90% sequence identity to SEQ ID NO: 2012.