Patent ID: 11896655
Assignee: FRED HUTCHINSON CANCER CENTER
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C  Y | IPC A

Claim 7:
8. A circumsporozoite protein (CSP) comprising
i) a KKNSR (SEQ ID NO: 1) to SSNSS (SEQ ID NO: 2) mutation directly upstream of a SLGENDD (SEQ ID NO: 3) cleavage site within the N-terminal domain of a wild-type Plasmodium falciparum CSP; or
ii) a KKNSR (SEQ ID NO: 1) to SSNSA (SEQ ID NO: 4) mutation directly upstream of a SLGENDD (SEQ ID NO: 3) cleavage site within the N-terminal domain of a wild-type Plasmodium falciparum CSP;, wherein the wild-type Plasmodium falciparum CSP comprises a sequence as set forth in SEQ ID NOs: 7, 10, or 19.