Patent ID: 11906508
Assignee: AGILENT TECHNOLOGIES, INC.
Field: Measurement (Instruments)
Classification: CPC G | IPC G

Claim 0:
1. An apparatus for continuous, label free, real-time monitoring of cells using impedance-based analysis, the apparatus comprising:
a) a multiwell plate comprising a plurality of wells on a nonconductive substrate, wherein each of the plurality of wells comprises an electrode array of a plurality of electrode arrays that is disposed on the nonconductive substrate;
b) an impedance analyzer that independently measures a cell-substrate impedance at each well, the cell-substrate impedance being measured between a first electrode structure and a second electrode structure of the electrode array and across a cellular sample comprising a plurality of cells disposed within each well, the impedance analyzer including
at least two analogue-to-digital conversion channels coupled to the plurality of electrode arrays, wherein the impedance analyzer monitors the electrode arrays at millisecond time resolution between first measurements of the cell-substrate impedance and second measurements of the cell-substrate impedance for each well; and
c) a software program that analyzes the first measurements and the second measurements to produce a time period analysis of the cellular sample.