Patent ID: 11857519
Assignee: ARVINAS OPERATIONS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 0:
1. A compound having the chemical structure:

ULM-L-PTM,

or a pharmaceutically acceptable salt thereof,
wherein:
(a) the ULM is:, wherein:
W is CH2 or C═O;
A is H;
 represents a bond that may be stereospecific or non-stereospecific;
n is 1; and
R is a bond to the chemical linking moiety or NHR′ covalently joined to the chemical linking moiety;
R′ is alkyl;
(b) the L is a chemical linking moiety connecting the ULM and the PTM which comprises (1) a chemical structural unit represented by the formula:
—(CH2)m-O(CH2)n-O(CH2)o-O(CH2)p-O(CH2)q-O(CH2)r-O—, —NH—(CH2)m-O(CH2)n-O(CH2)o-O(CH2)p-O(CH2)q-O(CH2)r-O—;, wherein:
each m, o, p, q, and r of the chemical linking moiety are independently 0, 1, 2, 3, 4, 5, 6, with the proviso that when the number is zero, there is no N—O or O—O bond;
n of the chemical linking moiety is 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10; or

(2) a polyethylenoxy group comprising 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10 ethylene glycol units; and
(c) the PTM is PTM-I-1, PTM-IVa-1, or PTM-IVb-1:, wherein:
WPTM and XPTM are independently C or N;
YPTM and ZPTM are CH;
XPTM1 is NH or O;
XPTM2 is absent;
RPTM is methyl or methoxy;
RPTM5 is methyl; and
 indicates a covalent linkage to the chemical linking moiety.