Patent ID: 11938218
Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 0:
1. A copolymer having the formula:

R1-[M(O)]n-[M(P)]m—R2 

wherein,
n and m are each an integer from 2 to 1000, provided that n is greater than m;
M is a polymerized ROMP polymerizable monomer;
O is independently a therapeutic polypeptide covalently attached to M through a covalent linker; wherein the therapeutic polypeptide is capable of treating a disease and is a cell growth or proliferation inhibitory peptide, an anti-inflammatory peptide, an anti-tumor or anti-cancer peptide, an anti-apoptotic peptide, anti-diabetic peptide, anti-obesity peptide, anti-infective peptide, anti-bacterial peptide, anti-viral peptide, a peptide for promoting cell growth and differentiation, a peptide for treating pain, a peptide for treating neural degeneration or peptides for promoting neurogenesis;
P is independently a non-polypeptide moiety; and
R1 and R2 are independently terminal polymer moieties,

wherein the polymerizable monomer is N-substituted-5-norbornene-2,3-dicarboximide,
wherein the substitution comprises the therapeutic polypeptide, and
wherein the therapeutic polypeptide comprises from 5 to 2000 amino acids.