Patent ID: 11905308
Assignee: OSAKA UNIVERSITY
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC C

Claim 0:
1. A nucleic acid compound represented by the following formula (I) or the following formula (II), or a salt thereof:, wherein
X1 and X2 are each independently S or Se,
Y is O, S, an —N(R19)— group, a —C(═O)—O— group, or a —C(═O)—N(R20)— group, R19 and R20 are each independently H or a C1-6 alkyl group, and Z is a cyclopropyl group represented by the following formula (VII):, wherein R21 and R22 are each independently H, a C1-6 alkyl group, or R21 and R22 are optionally joined to form a C1-4 alkylene group, or
Y and Z are joined to form a —C(═O)—O— group or a —C(═O)—N(R20)— group and R20 is H or a C1-6 alkyl group,
R1 is H or a C1-6 alkyl group,
R2 and R3 are each independently H, a hydroxyl-protecting group, or a phosphate group represented by the following formula (VIII):, wherein Q is O or S, R23 is H, a hydroxyl group, or a C1-6 alkoxy group optionally substituted by a cyano group; R24 is a hydroxyl group, a C1-6 alkoxy group optionally substituted by a cyano group or an NR25R26 group wherein R25 and R26 are each independently H, a C1-6 alkyl group or a 2-cyanoethyl group; and n is 0 or 1, and
R4 is H, a C1-6 alkyl group or a 2-cyanoethyl group.