Patent ID: 11970507
Assignee: ORIENTAL(LUZHOU) AGROCHEMICALS CO., LTD.
Field: Organic fine chemistry (Chemistry)
Classification: CPC C | IPC C

Claim 0:
1. A method for preparing a 2-arylmalonic acid derivative of formula (3), comprising:
(1) subjecting a compound (1) to an isomerization reaction in the presence of a base to obtain an intermediate (2), as shown in the following reaction scheme:, wherein the base is selected from the group consisting of an alkali metal hydroxide, an alkali metal alcoholate and a combination thereof; and
(2) subjecting the intermediate (2) to a halogenation reaction in the presence of a halogenating agent to produce a halogenated product, and subjecting the halogenated product to a dehydrohalogenation-aromatization reaction under a temperature of 110-150° C. to obtain the 2-arylmalonic acid derivative (3), as shown in the following reaction scheme:, wherein the halogenating agent is selected from the group consisting of an elemental halogen and sulfuryl chloride;
wherein R1, R2, R3, R4 and R5 are each independently hydrogen or a C1-C4 alkyl group;
Y1 and Y2 are each independently cyano, —COOMe or —COOEt.