Patent ID: 11890302
Assignee: TC BIOPHARM LIMITED
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A gamma delta T cell comprising a nucleic acid construct to provide for expression of a CAR comprising:
(i) an antigen-binding domain coupled to a trans-membrane domain, and
(ii) an intracellular activation signalling domain, wherein the intracellular signalling domain consists of one or more Fcγ Receptor intracellular signalling domains, wherein the one or more Fcγ Receptor intracellular signalling domains is from an Fc R common gamma chain, a CD16, a CD32a, a CD32c, or a CD64, and wherein binding of antigen to the antigen binding domain of the CAR causes signalling by the intracellular signalling domain of the CAR.