Patent ID: 11918957
Assignee: DONALDSON COMPANY, INC.
Field: Chemical engineering (Chemistry)
Classification: CPC B  C | IPC B  C

Claim 0:
1. A method for preparing an adsorptive media for binding biologic molecules, the method comprising:
immersing a macroporous support in a first solution comprising a coupling reagent and a first solvent for attachment of said coupling reagent to form coupling groups on the macroporous support;
immersing said macroporous support in an incubating solution to couple a molecule having an affinity to a biological target to at least a portion of said coupling groups, the incubating solution comprising:
water;
an organic solvent present in an amount ranging from 90% to 110% of a volumetric amount of the organic solvent at the cloud point of the ligand; and
the molecule comprising a nucleotide, an oligonucleotide, a peptide, a polypeptide, a protein, or any combination thereof.