Patent ID: 11944424
Assignee: DUKE UNIVERSITY
Field: Measurement (Instruments)
Classification: CPC A  G | IPC A  G

Claim 40:
41. A method of generating spectroscopy parameters for medical evaluation of a subject, comprising:
obtaining a series of 129Xe free induction decays (FIDs) of a gas exchange region of a lung or lungs of the subject during a breathing maneuver;
fitting real and imaginary components of the FIDs in a time domain with a curve fitting function modeled with one or more non-Lorentzian line shapes, wherein the curve fitting function models each of a 129Xe barrier resonance, a 129Xe gas-phase resonance and a 129Xe red blood cell (RBC) resonance, with the 129Xe barrier resonance modeled, at least in part, with the one or more non-Lorentzian line shapes; and
electronically generating a plurality of 129Xe spectral parameters comprising RBC spectral parameters of RBC amplitude, RBC chemical shift (ppm), RBC full width at half maximum (FWHM) (ppm) and RBC phase (degrees) based on the fitting, wherein the plurality of 129Xe spectral parameters include static and dynamic 129Xe spectral parameters using plots over time of at least one of:
(i) barrier amplitude, barrier chemical shift (ppm), and one or more barrier FWHM (ppm) parameters; and
(ii) the RBC amplitude, the RBC chemical shift (ppm), the RBC FWHM (ppm), and the RBC phase (degrees),
wherein the static and dynamic 129Xe spectral parameters comprise RBC amplitude oscillations, RBC chemical shift oscillations, RBC FWHM oscillations and RBC phase oscillations;
electronically providing a database comprising a plurality of defined different disease patterns of the 129Xe spectral parameters correlated to different pulmonary hypertension and/or interstitial lung diseases, wherein at least some of the plurality of defined disease patterns comprise defined sets of one or more features of at least two of the RBC amplitude oscillations, the RBC chemical shift oscillations, the RBC FWHM oscillations and the RBC phase oscillations; and
wherein, when the RBC amplitude oscillations are at least 1.5X larger than a healthy cohort, and when the RBC (chemical shift) oscillations and the RBC phase oscillations are at least 2X above a healthy cohort, identifying that the subject has Idiopathic pulmonary fibrosis (IPF).