Patent ID: 11860161
Assignee: SEATTLE CHILDREN'S HOSPITAL
Field: Pharmaceuticals (Chemistry)
Classification: CPC G  A  C  Y | IPC A  C  G

Claim 0:
1. A method of distinguishing between the presence of systemic lupus erythematosus (SLE) and a bacterial or viral infection comprising:
(a) obtaining a blood sample from a human subject;
(b) contacting the blood sample with a detectably labeled antibody specific for PD-L1 and at least one antibody specific for a cell surface marker on a monocyte or dendritic cell;
(c) detecting the presence or absence of monocytes or dendritic cells; and
(d) determining the amount of PD-L1 in a blood sample containing monocytes or dendritic cells, wherein a PD-L1 amount from monocytes or dendritic cells that is lower than a control value is indicative of SLE and a PD-L1 amount from monocytes or dendritic cells that is higher than the control value is indicative of a bacterial or viral infection, wherein the control value is established based on a PD-L1 amount of one or more healthy subjects.