Patent ID: 11873289
Assignee: MYOKARDIA, INC.
Field: Organic fine chemistry (Chemistry)
Classification: CPC A  C  B  Y | IPC B  C

Claim 0:
1. A process for preparation of a compound of formula II,, wherein R2 is F, C1-C4 alkyl, or C1-C4 haloalkyl,
R3 is, F, C1-C4 alkyl, or C1-C4 haloalkyl,
R4 is C1-C4 alkyl,
R6 is H or a protecting group or a salt thereof, and
R7 is H, Cl or trialkylsilyl,
comprising the steps of:
a) reacting a compound of formula VII with elemental sulfur in the presence of a base, a catalyst and a reducing agent to give a compound of formula VI;, wherein R3, R4 and R7 are as defined above and L1 is a leaving group;
b) reacting the compound of formula VI with a compound of formula VIII, to give a compound of formula V;, wherein L2 is a leaving group and R3, R4, R6 and R7 are as defined above; and
c) converting the compound of formula V to the compound of formula II.