Patent ID: 11944646
Assignee: AVOTRES, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C  G | IPC A  C  G

Claim 0:
1. A method for treating type 1 diabetes (T1D) in a human individual in need thereof, comprising:
(a) selecting a human individual in need of T1D treatment and having a C-peptide level at least 0.2 nmol/L;
(b) preparing autologous immature dendritic cells from the human individual of step (a), wherein the prepared autologous immature dendritic cells are loaded with human heat shock protein 60 signal peptide (hHsp60sp) and fixed with paraformaldehyde (PFA);
(c) testing the prepared autologous immature dendritic cells of step (b) in a potency assay, wherein the potency assay comprises specific target cells from the cell line having the ATCC accession number PTA-127256 and control target cells from the cell line having the ATCC accession number PTA-127257;
(d) obtaining the prepared autologous immature dendritic cells having at least 50% potency in the potency assay of step (c); and
(e) administering to the human individual a therapeutically effective amount of the prepared autologous immature dendritic cells from step (d).