Patent ID: 11939403
Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Field: Biotechnology (Chemistry)
Classification: CPC C | IPC C

Claim 24:
25. A method of designing and preparing a permeable cyclic decapeptide-peptoid ligand of a structure, wherein Za1 is X1 or methyl (CH3—),
wherein Za2 is X2 or methyl (CH3—),
wherein Za4 is H or 2-methylpropyl, wherein Za5 is H or 2-methylpropyl, wherein Zb1 is X1 or methyl (CH3—),
wherein Zb2 is X2 or methyl (CH3—),
wherein Zb4 is H or methyl (CH3—),
wherein Zb5 is H or methyl (CH3—),
wherein Zc1 is 2-methylpropyl, , or methyl (CH3—),
wherein Zc2 is 2-methylpropyl, , or methyl (CH3—),
wherein X1 is selected from the group consisting of ethyl (Et-), , 2-propoxy-3-propyl, , and (1,3-benzodioxol-5-yl)-methyl, wherein X2 is selected from the group consisting of pentyl, , cyclohexylmethyl, , and (oxan-4-yl)methyl, , and
wherein X3 is selected from the group consisting of methyl, , and benzyl, comprising
determining whether a required minimum aqueous solubility of the ligand requires the ligand to be of an A Log P of at most 1.9 or whether the required minimum aqueous solubility of the ligand allows the ligand to be of an A Log P of greater than 1.9,
wherein when the ligand is required to be of an A Log P of at most 1.9, selecting Za4 as H, Zb1 as CH3, Za5 as H, and Zb2 as CH3,
wherein when the ligand is allowed to be of an A Log P of greater than 1.9, selecting Za4 as 2-methylpropyl, Zb1 as X1, Za5 as 2-methylpropyl, and Zb2 as X2, and
synthesizing the ligand.