Patent ID: 11939395
Assignee: MORPHOSYS AG
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC C

Claim 0:
1. A method for generating variants of an anti-CD38 antibody comprising a VH of SEQ ID NO: 21 and a VL of SEQ ID NO: 51, said method comprising the steps of:
i) diversifying one or more amino acid residues within one or more CDR regions or one or more framework regions of the anti-CD38 antibody comprising the VH of SEQ ID NO: 21 and the VL of SEQ ID NO: 51;
ii) generating a recombinant antibody library comprising antibodies with the one or more diversified amino acid residues; and
iii) screening antibodies of the recombinant antibody library against a CD38 antigen.