Patent ID: 11865120
Assignee: NEUPHARMA, INC
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C  G | IPC A  C  G

Claim 0:
1. A process for preparing a compound having the structure of Formula Ib″:, comprising
(i) contacting a compound having the structure of Formula A:, with a compound having a structure of Formula B:, in the presence of a base and a palladium catalyst under reaction conditions that provide a compound having the structure of Formula C:, , and
contacting a compound having the structure of Formula C with acryloyl chloride to provide the compound having the structure of Formula Ib″;
wherein
X1 is N or C—R2;
each R1, R2, R4, and R5 is independently H or halo;
R3 is optionally substituted heterocycloalkyl;
each R6, R12, R13, and R14 is independently H; and
R′ are each independently OH or both R′ taken together with the oxygen atoms to which they are attached to form a 5-membered optionally substituted boronic ester.