Patent ID: 11896670
Assignee: MIND MEDICINE, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A

Claim 1:
2. A method of synthesizing a pharmacological compound substance including the steps of:
reducing 1-(3,4-Dibenzyloxyphenyl)-2-nitropropene to a ketone 3,4-Dibenzyloxyphenylacetone;
applying reductive amination conditions to 3,4-Dibenzyloxyphenylacetone to obtain 3,4-Dibenzyloxymethamphetamine hydrochloride;
reacting 3,4-Dibenzyloxymethamphetamine hydrochloride with an activated lysine derivative to obtain Boc-L-Lys(Boc)-3,4-dibenzyloxymethamphetamine;
performing a hydrogenolytic removal of O-benzyl groups on Boc-L-Lys(Boc)-3,4-dibenzyloxymethamphetamine to obtain Boc-L-Lys(Boc)-3,4-dihydroxymethamphetamine;
O,O′—methylating Boc-L-Lys(Boc)-3,4-dihydroxymethamphetamine to obtain Boc-L-Lys(Boc)-3,4-methylenedioxymethamphetamine; and
deprotecting Boc-L-Lys(Boc)-3,4-methylenedioxymethamphetamine to obtain L-Lys-(R,S)-MDMA.