Patent ID: 11952423
Assignee: DAIICHI SANKYO COMPANY, LIMITED
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC C

Claim 13:
14. The molecule according to claim 10, wherein the antibody or fragment thereof that binds specifically to CD3 is a Fab comprising:
(CH1CL1) a heavy chain variable region comprising an amino acid sequence consisting of amino acids 2 to 119 of the amino acid sequence of SEQ ID NO: 136 and a light chain variable region comprising an amino acid sequence consisting of amino acids 135 to 243 of the amino acid sequence of SEQ ID NO: 136;
(CH2CL2) a heavy chain variable region comprising an amino acid sequence consisting of amino acids 2 to 119 of the amino acid sequence of SEQ ID NO: 137 and a light chain variable region comprising an amino acid sequence consisting of amino acids 135 to 241 of the amino acid sequence of SEQ ID NO: 137;
(CH3CL3) a heavy chain variable region comprising an amino acid sequence consisting of amino acids 2 to 119 of the amino acid sequence of SEQ ID NO: 147 and a light chain variable region comprising an amino acid sequence consisting of amino acids 135 to 243 of the amino acid sequence of SEQ ID NO: 147;
(CH4CL4) a heavy chain variable region comprising an amino acid sequence consisting of amino acids 2 to 119 of the amino acid sequence of SEQ ID NO: 138 and a light chain variable region comprising an amino acid sequence consisting of amino acids 135 to 241 of the amino acid sequence of SEQ ID NO: 138;
(CH5CL5) a heavy chain variable region comprising an amino acid sequence consisting of amino acids 2 to 119 of the amino acid sequence of SEQ ID NO: 139 and a light chain variable region comprising an amino acid sequence consisting of amino acids 135 to 243 of the amino acid sequence of SEQ ID NO: 139;
(CH6CL6) a heavy chain variable region comprising an amino acid sequence consisting of amino acids 2 to 119 of the amino acid sequence of SEQ ID NO: 140 and a light chain variable region comprising an amino acid sequence consisting of amino acids 135 to 243 of the amino acid sequence of SEQ ID NO: 140;
(CH7CL7) a heavy chain variable region comprising an amino acid sequence consisting of amino acids 272 to 389 of the amino acid sequence of SEQ ID NO: 155 and a light chain variable region comprising an amino acid sequence consisting of amino acids 405 to 511 of the amino acid sequence of SEQ ID NO: 155;
(CH8CL8) a heavy chain variable region comprising an amino acid sequence consisting of amino acids 277 to 394 of the amino acid sequence of SEQ ID NO: 156 and a light chain variable region comprising an amino acid sequence consisting of amino acids 410 to 516 of the amino acid sequence of SEQ ID NO: 156; or
(CH9CL9) a heavy chain variable region comprising an amino acid sequence consisting of amino acids 277 to 394 of the amino acid sequence of SEQ ID NO: 157 and a light chain variable region comprising an amino acid sequence consisting of amino acids 410 to 516 of the amino acid sequence of SEQ ID NO: 157.