Patent ID: 11884707
Assignee: REGENERON PHARMACEUTICALS, INC.
Field: Measurement (Instruments)
Classification: CPC C  G  A | IPC A  C  G

Claim 0:
1. A binding agent that specifically binds indoleamine 2,3-dioxygenase 1 (IDO1) comprising a first ligand having affinity for an epitope on IDO1, wherein the ligand comprises a cyclic peptide having an amino acid sequence selected from the group consisting of:
(a) X1rf(Me-Trp)X2, wherein X1 and X2 are independently D-Ala, D-Arg, D-Asn, D-Asp, D-Glu, Gly, D-His, D-Leu, D-Lys, D-Phe, D-Pro, D-Ser, D-Thr, D-Trp, D-Tyr, or D-Val or is not present;
(b) nsfr(Me-Trp);
(c) wyrX3y, wherein X3 is D-Ala or is not present;
(d) rys(Me-Trp)r;
(e) X4lf(Me-Trp)(F-Phe), wherein X4 is D-Ala, D-Arg, D-Asn, D-Asp, D-Glu, Gly, D-His, D-Leu, D-Lys, D-Phe, D-Pro, D-Ser, D-Thr, D-Trp, D-Tyr, or D-Val or is not present;
(f) nlw(Me-Trp)r;
(g) sX5ww(F-Phe), wherein X5 is D-Ala, D-Arg, D-Asn, D-Asp, D-Glu, Gly, D-His, D-Leu, D-Lys, D-Phe, D-Pro, D-Ser, D-Thr, D-Trp, D-Tyr, or D-Val or is not present;
(h) rffyl; and
(i) nsh(F-Phe)r.