Patent ID: 11911513
Assignee: SHANGHAI WD PHARMACEUTICAL CO., LTD
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 4:
5. The method of claim 4, wherein in the extended release platform:
when the excipient comprises a filler, the filler is one or more of microcrystalline cellulose, hydroxypropyl cellulose and mannitol, and the weight percentage of the filler is 0-50% but not 0%;
or, when the excipient comprises an osmotic agent, the osmotic agent is one or more of magnesium sulfate, magnesium chloride, sodium chloride, lithium chloride, potassium sulfate, sodium sulfate, mannitol, urea, sorbitol, inositol, sucrose, glucose, and the weight percentage of the osmotic agent is 0-50% but not 0%;
or, when the excipient comprises a hydrophilic polymer, the hydrophilic polymer is one or more of hydroxypropyl cellulose, hydroxypropyl methyl cellulose, carboxymethyl cellulose, polyvinylpyrrolidone and hydroxyethyl cellulose, and the weight percentage of the hydrophilic polymer is 0-50% but not 0%;
or, when the excipient comprises an acidifying agent, the acidifying agent is one or more of citric acid, sodium citrate, potassium citrate, malic acid, fumaric acid, lactic acid, phosphoric acid and tartaric acid, and the weight percentage of the acidifying agent is 0-10% but not 0%;
wherein the weight percentage is the weight percentage of each component of the drug-containing layer;
or, wherein in the extended release platform, the hydrophilic polymer in the osmotic push layer is x-carrageenan, sodium carboxymethyl cellulose or polyethylene oxide, wherein the molecular weight of the hydrophilic polymer is 75,000-7,500,000, and the weight percentage of the hydrophilic polymer is 25-85%;
or, the osmotic agent in the osmotic pump push layer is one or more of magnesium sulfate, magnesium chloride, sodium chloride, lithium chloride, potassium sulfate, sodium sulfate, mannitol, urea, sorbitol, inositol, sucrose, glucose, and the weight percentage of the osmotic agent is 5-65%;
or, when the osmotic push layer comprises a binding agent, the binding agent is one or more of methyl cellulose, hydroxypropyl methyl cellulose, hydroxypropyl cellulose, sodium carboxymethyl cellulose, povidone and gelatin, and the weight percentage of the binding agent is 3-20%;
or, when the osmotic push layer comprises a lubricant, the lubricant is one or more of magnesium stearate, magnesium stearate fumarate, talc, and colloidal silica, and the weight percentage of the lubricant is 0-2% but not 0%;
or, when the osmotic push layer comprises a colorant, the colorant is one or more of iron oxide red, iron oxide yellow, and iron oxide black, and the weight percentage of the colorant is 0-5% but not 0%;
wherein the weight percentage is the weight percentage of each component of the osmotic push layer;
or, wherein in the extended release platform, the osmotic push layer comprises sodium carboxymethyl cellulose, povidone K30, sorbitol, iron oxide red and magnesium stearate;
or comprises sodium carboxymethyl cellulose, hydroxypropyl cellulose, sorbitol, iron oxide red and magnesium stearate;
or, the sodium carboxymethyl cellulose is sodium carboxymethyl cellulose 7H4XF or 9H4XF;
or, the osmotic push layer comprises 25-85 wt % of sodium carboxymethyl cellulose, 5-65 wt % of sorbitol, 3-20 wt % of povidone, 0-5 wt % of iron oxide red and 0.5-2 wt % of magnesium stearate;
or, the osmotic push layer comprises 55 wt % of sodium carboxymethyl cellulose, 34.0-39.0 wt % of sorbitol, 3-20 wt % of povidone or 10 wt % of hydroxylpropyl cellulose, 0.5-5 wt % of iron oxide red and 0.5-2 wt % of magnesium stearate;
or, the osmotic push layer comprises 55 wt % of sodium carboxymethyl cellulose, 39.0 wt % of sorbitol, 5.0 wt % of povidone and 0.5 wt % of iron oxide red and 0.5 wt % of magnesium stearate; or comprises 55 wt % of sodium carboxymethyl cellulose, 34.0 wt % of sorbitol, 10.0 wt % of povidone, 0.5 wt % of iron oxide red and 0.5 wt % of magnesium stearate, or comprises 55 wt % of sodium carboxymethyl cellulose, 34.0 wt % of sorbitol, 10.0 wt % of hydroxypropyl cellulose, 0.5 wt % of iron oxide red and 0.5 wt % of magnesium stearate; wherein the weight percentage is the weight percentage of each component of the osmotic push layer.