Patent ID: 11938187
Assignee: CITY UNIVERSITY OF HONG KONG
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 0:
1. A conjugated molecule comprising a photocleavable group linked to a nucleic acid, wherein
the photocleavable group is a 4,4′-bis-(8-(4-(nitro-3-(2-propyl)-styryl))-3,3′-dimethoxybiphenyl (BNSMB) group conferred by 2-(5-((E)-2-(4′-((E)-3-(1-bis(4-methoxyphenyl)(phenyl)methoxy)propan-2-yl)-4-nitrostyryl)-3.3′-dimethoxy-[1,1′-biphenyl]-4-yl)vinyl)-2-nitrophenyl)propyl(2-cyanoethyl) diisopropylphosphoramidite coupled to the nucleic acid during synthesis of the conjugated molecule; and
the conjugated molecule is capable of releasing the nucleic acid therefrom upon being exposed to near infrared (NIR) light to cleave away the photocleavable group.