Patent ID: 11963775
Assignee: SAFEOP SURGICAL, INC.
Field: Medical technology (Instruments)
Classification: CPC A | IPC A

Claim 0:
1. A medical method of automatically improving signals received from a patient's physiological system comprising:
delivering stimulation signals to a nerve pathway of a patient with electrical pulses via electrodes placed over the nerve pathway to generate a plurality of resultant evoked potentials (EPs) based on a plurality of electrophysiological responses (ERs);
recording the plurality of resultant EPs;
generating an ensemble average waveform (EA), the generating comprising averaging a subset of the plurality of ERs;
denoising the EA to generate a denoised EA comprising a denoised signal, the denoising comprising:
decomposing, hierarchically, the EA using a series of filter banks, wherein filter coefficients of the series of filter banks used in the hierarchical decomposition are derived from a mother wavelet derived from an electrophysiological response of interest, and wherein the decomposing comprises applying a first wavelet transform;
iterating the hierarchical decomposition of the EA, the hierarchical decomposition of the EA filtering high-frequency noise from the EA;
applying a dynamic coefficient threshold to the filter coefficients, the dynamic coefficient threshold determined with the EA; and
applying a second wavelet transform to the EA, the second wavelet transform comprising an inverse wavelet transform using the mother wavelet derived from the electrophysiological response of interest;

comparing the denoised EA to a previously denoised EA;
determining whether a change has occurred in the denoised EA relative to the previously denoised EA; and
generating, based on the determination that the change has occurred, an alert.