Patent ID: 11938348
Assignee: GENERAL ELECTRIC COMPANY
Field: Medical technology (Instruments)
Classification: CPC A | IPC A

Claim 15:
16. A modulation system comprising:
at least one energy application device comprising an ultrasound probe configured to apply energy to a first region of interest of a first tissue in a subject, the first tissue comprising a plurality of axon terminals of respective neurons, the axon terminals forming synapses between individual axon terminals and respective no n-neuronal cells and to apply energy to a second region of interest of a second tissue in the subject; and
a controller configured to:
spatially select the first region of interest of the first tissue and the second region of interest in the second tissue;
focus the energy on the first region of interest and the second region of interest;
adjustably control application of the energy via the at least one energy application device to the first region of interest to induce preferential activation of a subset of the synapses, the subset being located in the first region of interest, to cause a first molecule concentration of a first molecule to change and control application of the energy via the at least one energy application device to the second region of interest to cause a second molecule concentration of a second molecule to change;
cause the ultrasound probe to operate in an imaging mode configured to acquire reference image data before the application of the energy and post-treatment image data after the application of the energy;
determine a displacement measurement of the first region of interest and/or the second region of interest based on a comparison of the reference image data and the post-treatment image data; and
modify a modulation parameter of the energy based on the displacement measurement being below a threshold displacement associated with a concentration change of the first molecule.