Patent ID: 11926667
Assignee: JANSSEN BIOTECH, INC.
Field: Biotechnology (Chemistry)
Classification: CPC C | IPC C

Claim 6:
7. The antibody of claim 1, wherein:
(A) (i) the antibody that binds to CD8 binds a CD8 antigen or a CD8 epitope, wherein optionally the antibody specifically binds the CD8 antigen or CD8 epitope;
(ii) the antibody that binds to CD4 binds a CD4 antigen or a CD4 epitope, wherein optionally the antibody specifically binds the CD4 antigen or CD4 epitope; or
(iii) the multispecific antibody that binds to CD8 and CD4 comprises a first binding domain that binds to a CD8 antigen or a CD8 epitope, and a second binding domain that binds to a CD4 antigen or a CD4 epitope;
wherein optionally
(a) the first binding domain specifically binds the CD8 antigen or CD8 epitope,
(b) the second binding domain specifically binds the CD4 antigen or CD4 epitope, or
(c) the first binding domain specifically binds the CD8 antigen or CD8 epitope, and the second binding domain specifically binds the CD4 antigen or CD4 epitope; or

(B) (i) the CD8 is present on the surface of a T cell;
(ii) the CD4 is present on the surface of a T cell; or
(iii) both the CD8 and CD4 are present on the surface of a T cell.