Patent ID: 11945838
Assignee: INDIAN INSTITUTE OF SCIENCE EDUCATION AND RESEARCH
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A site-modified protein/peptide amphiphile of general Formula (Ia),

MP-SG-HT  (Ia)

wherein:
MP is a modified protein selected from the group consisting of a modified bovine serum albumin (BSA), a modified green fluorescent protein (GFP), a modified lysozyme, modified proteases, a modified subtilisin, a modified fusion protein, genetically edited modified proteins, modified antibodies, and modified peptides;
SG is a functionalized oligoethylene glycol hydrophilic spacer group bound to an N-terminal amino acid of the modified protein MP;
HT is a hydrophobic tail comprising a benzyl ether dendrimer with an alkyl chain;
wherein the site-modified protein/peptide amphiphile of general Formula (Ia) is a a reaction product obtained by reaction between the N-terminal amino acid of the modified protein MP and a 2-pyridine carboxaldehyde (2-PCA) compound of formula II:,