Patent ID: 11903995
Assignee: L'OREAL
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 0:
1. A method for the treatment of acneic skin which comprises contacting the acneic skin with an effective amount of an arthrofactin mixture comprising
(i) arthrofactin A of formula (I) below:

R1-D-Leu1-D-Asp2-D-allo-Thr3-D-Leu4-D-Leu5-D-Ser6-L-Leu7-D-Ser8-L-Ile9-L-Ile10-L-Asp11  (I),

in which
the hydroxyl group of the D-allo-Thr3 amino acid residue forms an ester bond with the C-terminal carboxyl group of the L-Asp11 amino acid residue, and
R1 represents the group of formula (I′) below:, where R1′ is a saturated alkyl chain of 5 to 8 carbon atoms; and

(ii) at least one derivative of arthrofactin A, said derivative being of formula (II) below:

R-Xaa1-Xaa2-Xaa3-Xaa4-Xaa5-Xaa6-Xaa7-Xaa8-Xaa9-Xaa10-Xaa11  (II)

in which
Xaa1, Xaa4, Xaa5, Xaa7, Xaa9 and Xaa10 each represent, independently, D-Leu, L-Leu, D-Ile or L-Ile,
Xaa2 and Xaa11 each represent, independently, D-Asp, L-Asp, D-Glu or L-Glu,
Xaa3 represents D-Thr, L-Thr, D-allo-Thr or L-allo-Thr,
Xaa6 and Xaa8 each represent, independently, D-Ser, L-Ser, D-Gln or L-Gln,
the hydroxyl group of the Xaa3 amino acid residue forms an ester bond with the C-terminal carboxyl group of the Xaa11 amino acid residue, and
R represents the group of formula (II′) below:, where R′ is an alkyl chain of 5 to 9 carbon atoms, optionally comprising at least one unsaturation.