Patent ID: 11965162
Assignee: THE JOHNS HOPKINS UNIVERSITY
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 6:
7. A method of treating pancreatic cancer, pancreatic dysplasia, or a pre-cancerous pancreatic cancer in a subject comprising:
administering to the subject a composition comprising a therapeutically effective amount of a microRNA-21 (miRNA-21) inhibitor, wherein the miRNA inhibitor is an antagomir, siRNA or antisense oligonucleotide or combination thereof,
and wherein dysregulated expression of one or more microRNAs (miRNAs) selected from miR-21, miR-16 or miR-28 is detected in the subject at a pre-malignant stage or early stages of developing pancreatic cancer, as compared to a normal subject;
thereby treating the cancer.