Patent ID: 11919868
Assignee: RECURSION PHARMACEUTICALS, INC.
Field: Organic fine chemistry (Chemistry)
Classification: CPC A  C  Y | IPC A  C

Claim 12:
13. A compound which is selected from:
(R)-2-chloro-4-((2,5-dioxo-3-(pyridin-2-ylmethyl)-1,2,3,5-tetrahydro-4H-thieno[3,2-e][1,4]diazepin-4-yl)methyl)-N-(4-methoxypyridin-2-yl)benzamide;
(R)-2-chloro-N-(4-methoxypyridin-2-yl)-4-((1-methyl-5,8-dioxo-6-(pyridin-2-ylmethyl)-4,5,6,8-tetrahydropyrazolo[4,3-e][1,4]diazepin-7(1H)-yl)methyl)benzamide;
(R)-2-chloro-4-((8-chloro-2,5-dioxo-3-(pyridin-2-ylmethyl)-1,2,3,5-tetrahydro-4H-pyrido[3,2-e][1,4]diazepin-4-yl)methyl)-N-(4-methoxypyridin-2-yl)benzamide;
2-chloro-4-((8-chloro-2,5-dioxo-3-(pyridin-2-ylmethyl)-1,2,3,5-tetrahydro-4H-pyrido[3,2-e][1,4]diazepin-4-yl)methyl)-N-(4-methoxypyridin-2-yl)benzamide;
(R)-2-chloro-4-((2,5-dioxo-3-(pyridin-2-ylmethyl)-1,2,3,5-tetrahydro-4H-thieno[3,2-e][1,4]diazepin-4-yl)methyl)-N-(pyridin-2-yl)benzamide;
2-chloro-4-((2,5-dioxo-3-(pyridin-2-ylmethyl)-1,2,3,5-tetrahydro-4H-thieno[3,2-e][1,4]diazepin-4-yl)methyl)-N-(5-methoxypyridin-2-yl)benzamide;
2-chloro-4-((7-methyl-2,5-dioxo-3-(pyridin-2-ylmethyl)-1,2,3,5-tetrahydro-4H-thieno[3,2-e][1,4]diazepin-4-yl)methyl)-N-(pyridin-2-yl)benzamide;
2-chloro-4-((2,5-dioxo-3-(pyridin-2-ylmethyl)-1,2,3,5-tetrahydro-4H-thieno[3,2-e][1,4]diazepin-4-yl)methyl)-N-(4-methoxypyridin-2-yl)benzamide;
2-chloro-4-((2,5-dioxo-3-(pyridin-2-ylmethyl)-1,2,3,5-tetrahydro-4H-pyrido[2,3-e][1,4]diazepin-4-yl)methyl)-N-(pyridin-2-yl)benzamide;
2-chloro-4-((2,5-dioxo-3-(pyridin-2-ylmethyl)-1,2,3,5-tetrahydro-4H-pyrido[2,3-e][1,4]diazepin-4-yl)methyl)-N-(5-methoxypyridin-2-yl)benzamide;
2-chloro-4-((2,5-dioxo-3-(pyridin-2-ylmethyl)-1,2,3,5-tetrahydro-4H-thieno[3,2-e][1,4]diazepin-4-yl)methyl)-N-(4-methylpyridin-2-yl)benzamide;
2-chloro-4-((2,5-dioxo-3-(pyridin-2-ylmethyl)-1,2,3,5-tetrahydro-4H-thieno[3,2-e][1,4]diazepin-4-yl)methyl)-N-(1H-pyrrolo[2,3-c]pyridin-5-yl)benzamide;
2-chloro-4-((2,5-dioxo-3-(pyridin-2-ylmethyl)-1,2,3,5-tetrahydro-4H-pyrido[2,3-e][1,4]diazepin-4-yl)methyl)-N-(4-methoxypyridin-2-yl)benzamide;
(R)-2-chloro-N-(4-cyclopropylpyridin-2-yl)-4-((2,5-dioxo-3-(pyridin-2-ylmethyl)-1,2,3,5-tetrahydro-4H-thieno[3,2-e][1,4]diazepin-4-yl)methyl)benzamide;
(R)-2-chloro-4-((2,5-dioxo-3-(pyridin-2-ylmethyl)-1,2,3,5-tetrahydro-4H-thieno[3,2-e][1,4]diazepin-4-yl)methyl)-N-(1H-pyrrolo[3,2-c]pyridin-6-yl)benzamide;
2-chloro-4-((2,5-dioxo-3-(pyridin-2-ylmethyl)-1,2,3,5-tetrahydro-4H-thieno[3,2-e][1,4]diazepin-4-yl)methyl)-N-(6-methoxypyrimidin-4-yl)benzamide;
2-chloro-4-((2,5-dioxo-3-(pyridin-2-ylmethyl)-1,2,3,5-tetrahydro-4H-thieno[3,2-e][1,4]diazepin-4-yl)methyl)-N-(imidazo[1,2-a]pyrazin-8-yl)benzamide;
2-chloro-4-((2,5-dioxo-3-(pyridin-2-ylmethyl)-1,2,3,5-tetrahydro-4H-thieno[3,2-e][1,4]diazepin-4-yl)methyl)-N-(imidazo[1,5-a]pyrazin-8-yl)benzamide;
2-chloro-4-((2,5-dioxo-3-(pyridin-2-ylmethyl)-1,2,3,5-tetrahydro-4H-thieno[3,2-e][1,4]diazepin-4-yl)methyl)-N-(4-methoxy-5-(trifluoromethyl)pyridin-2-yl)benzamide;
2-chloro-4-((5,8-dioxo-6-(pyridin-2-ylmethyl)-4,5,6,8-tetrahydro-7H-thiazolo[4,5-e][1,4]diazepin-7-yl)methyl)-N-(pyridin-2-yl)benzamide;
2-chloro-4-((5,8-dioxo-6-(pyridin-2-ylmethyl)-4,5,6,8-tetrahydro-7H-thiazolo[4,5-e][1,4]diazepin-7-yl)methyl)-N-(5-methoxypyridin-2-yl)benzamide;
2-chloro-4-((5,8-dioxo-6-(pyridin-2-ylmethyl)-4,5,6,8-tetrahydro-7H-thiazolo[4,5-e][1,4]diazepin-7-yl)methyl)-N-(4-methoxypyridin-2-yl)benzamide;
2-chloro-4-((2,5-dioxo-3-(pyridin-2-ylmethyl)-1,2,3,5-tetrahydro-4H-thieno[3,2-e][1,4]diazepin-4-yl)methyl)-N-(1H-pyrazolo[3,4-d]pyrimidin-4-yl)benzamide;
2-chloro-4-((2,5-dioxo-3-(pyridin-2-ylmethyl)-1,2,3,5-tetrahydro-4H-thieno[3,2-e][1,4]diazepin-4-yl)methyl)-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide;
2-chloro-4-((2,5-dioxo-3-(pyridin-2-ylmethyl)-1,2,3,5-tetrahydro-4H-thieno[3,2-e][1,4]diazepin-4-yl)methyl)-N-(5-(trifluoromethyl)pyridin-2-yl)benzamide;
2-chloro-4-((2,5-dioxo-3-(pyridin-2-ylmethyl)-1,2,3,5-tetrahydro-4H-thieno[3,2-e][1,4]diazepin-4-yl)methyl)-N-(1H-pyrazolo[3,4-c]pyridin-5-yl)benzamide;
2-chloro-N-(4-cyclopropoxypyridin-2-yl)-4-((2,5-dioxo-3-(pyridin-2-ylmethyl)-1,2,3,5-tetrahydro-4H-thieno[3,2-e][1,4]diazepin-4-yl)methyl)benzamide;
2-chloro-4-((2,5-dioxo-3-(pyridin-2-ylmethyl)-1,2,3,5-tetrahydro-4H-thieno[3,2-e][1,4]diazepin-4-yl)methyl)-N-(5-methoxypyridazin-3-yl)benzamide;
4-((2,5-dioxo-3-(pyridin-2-ylmethyl)-1,2,3,5-tetrahydro-4H-thieno[3,2-e][1,4]diazepin-4-yl)methyl)-3-fluoro-N-(pyridin-2-yl)benzamide;
4-((2,5-dioxo-3-(pyridin-2-ylmethyl)-1,2,3,5-tetrahydro-4H-thieno[3,2-e][1,4]diazepin-4-yl)methyl)-3-fluoro-N-(5-methoxypyridin-2-yl)benzamide;
2-chloro-N-(4-(difluoromethoxy)pyridin-2-yl)-4-((2,5-dioxo-3-(pyridin-2-ylmethyl)-1,2,3,5-tetrahydro-4H-thieno[3,2-e][1,4]diazepin-4-yl)methyl)benzamide;
2-chloro-4-((2,5-dioxo-3-(pyridin-2-ylmethyl)-1,2,3,5-tetrahydro-4H-thieno[3,2-e][1,4]diazepin-4-yl)methyl)-N-(4-(trifluoromethoxy)pyridin-2-yl)benzamide;
2-chloro-4-((2,5-dioxo-3-(pyridin-2-ylmethyl)-1,2,3,5-tetrahydro-4H-thieno[3,2-e][1,4]diazepin-4-yl)methyl)-N-(imidazo[1,2-a]pyrazin-6-yl)benzamide;
4-((2,5-dioxo-3-(pyridin-2-ylmethyl)-1,2,3,5-tetrahydro-4H-thieno[3,2-e][1,4]diazepin-4-yl)methyl)-3-fluoro-N-(4-methoxypyridin-2-yl)benzamide;
2-chloro-4-((7-chloro-2,5-dioxo-3-(pyridin-2-ylmethyl)-1,2,3,5-tetrahydro-4H-thieno[3,2-e][1,4]diazepin-4-yl)methyl)-N-(5-methoxypyridin-2-yl)benzamide;
6-((2,5-dioxo-3-(pyridin-2-ylmethyl)-1,2,3,5-tetrahydro-4H-thieno[3,2-e][1,4]diazepin-4-yl)methyl)-N-(pyridin-2-yl)nicotinamide;
5-((2,5-dioxo-3-(pyridin-2-ylmethyl)-1,2,3,5-tetrahydro-4H-thieno[3,2-e][1,4]diazepin-4-yl)methyl)-N-(4-methoxypyridin-2-yl)picolinamide;
5-((2,5-dioxo-3-(pyridin-2-ylmethyl)-1,2,3,5-tetrahydro-4H-thieno[3,2-e][1,4]diazepin-4-yl)methyl)-N-(5-methoxypyridin-2-yl)picolinamide;
2-chloro-4-((1-methyl-5,8-dioxo-6-(pyridin-2-ylmethyl)-4,5,6,8-tetrahydropyrazolo[4,3-e][1,4]diazepin-7(1H)-yl)methyl)-N-(pyridin-2-yl)benzamide;
2-chloro-N-(5-methoxypyridin-2-yl)-4-((1-methyl-5,8-dioxo-6-(pyridin-2-ylmethyl)-4,5,6,8-tetrahydropyrazolo[4,3-e][1,4]diazepin-7(1H)-yl)methyl)benzamide;
2-chloro-4-((5,8-dioxo-6-(pyridin-2-ylmethyl)-4,5,6,8-tetrahydropyrazolo[4,3-e][1,4]diazepin-7(1H)-yl)methyl)-N-(5-methoxypyridin-2-yl)benzamide;
2-chloro-4-((7-chloro-2,5-dioxo-3-(pyridin-2-ylmethyl)-1,2,3,5-tetrahydro-4H-thieno[3,2-e][1,4]diazepin-4-yl)methyl)-N-(pyridin-2-yl)benzamide;
2-chloro-4-((2-methyl-5,8-dioxo-6-(pyridin-2-ylmethyl)-4,5,6,8-tetrahydro-7H-thiazolo[4,5-e][1,4]diazepin-7-yl)methyl)-N-(pyridin-2-yl)benzamide;
6-((2,5-dioxo-3-(pyridin-2-ylmethyl)-1,2,3,5-tetrahydro-4H-thieno[3,2-e][1,4]diazepin-4-yl)methyl)-N-(4-methoxypyridin-2-yl)nicotinamide;
6-((2,5-dioxo-3-(pyridin-2-ylmethyl)-1,2,3,5-tetrahydro-4H-thieno[3,2-e][1,4]diazepin-4-yl)methyl)-N-(5-methoxypyridin-2-yl)nicotinamide;
5-((2,5-dioxo-3-(pyridin-2-ylmethyl)-1,2,3,5-tetrahydro-4H-thieno[3,2-e][1,4]diazepin-4-yl)methyl)-N-(pyridin-2-yl)picolinamide;
2-chloro-N-(4-methoxypyridin-2-yl)-4-((1-methyl-5,8-dioxo-6-(pyridin-2-ylmethyl)-4,5,6,8-tetrahydropyrazolo[4,3-e][1,4]diazepin-7(1H)-yl)methyl)benzamide;
2-chloro-4-((5,8-dioxo-6-(pyridin-2-ylmethyl)-4,5,6,8-tetrahydropyrazolo[4,3-e][1,4]diazepin-7(1H)-yl)methyl)-N-(pyridin-2-yl)benzamide;
2-chloro-4-((2-methyl-5,8-dioxo-6-(pyridin-2-ylmethyl)-2,5,6,8-tetrahydropyrazolo[4,3-e][1,4]diazepin-7(4H)-yl)methyl)-N-(pyridin-2-yl)benzamide;
2-chloro-N-(4-methoxypyridin-2-yl)-4-((2-methyl-5,8-dioxo-6-(pyridin-2-ylmethyl)-2,5,6,8-tetrahydropyrazolo[4,3-e][1,4]diazepin-7(4H)-yl)methyl)benzamide;
2-chloro-N-(5-methoxypyridin-2-yl)-4-((2-methyl-5,8-dioxo-6-(pyridin-2-ylmethyl)-2,5,6,8-tetrahydropyrazolo[4,3-e][1,4]diazepin-7(4H)-yl)methyl)benzamide;
2-chloro-4-((2,5-dioxo-3-(pyridin-2-ylmethyl)-2,3-dihydro-1H-thieno[3,4-e][1,4]diazepin-4(5H)-yl)methyl)-N-(pyridin-2-yl)benzamide;
2-chloro-4-((2,5-dioxo-3-(pyridin-2-ylmethyl)-2,3-dihydro-1H-thieno[3,4-e][1,4]diazepin-4(5H)-yl)methyl)-N-(5-methoxypyridin-2-yl)benzamide;
2-chloro-4-((7-cyclopropyl-2,5-dioxo-3-(pyridin-2-ylmethyl)-1,2,3,5-tetrahydro-4H-thieno[3,2-e][1,4]diazepin-4-yl)methyl)-N-(pyridin-2-yl)benzamide;
2-chloro-4-((7-cyclopropyl-2,5-dioxo-3-(pyridin-2-ylmethyl)-1,2,3,5-tetrahydro-4H-thieno[3,2-e][1,4]diazepin-4-yl)methyl)-N-(4-methoxypyridin-2-yl)benzamide;
4-((7-(tert-butyl)-2,5-dioxo-3-(pyridin-2-ylmethyl)-1,2,3,5-tetrahydro-4H-thieno[3,2-e][1,4]diazepin-4-yl)methyl)-2-chloro-N-(pyridin-2-yl)benzamide;
4-((7-(tert-butyl)-2,5-dioxo-3-(pyridin-2-ylmethyl)-1,2,3,5-tetrahydro-4H-thieno[3,2-e][1,4]diazepin-4-yl)methyl)-2-chloro-N-(4-methoxypyridin-2-yl)benzamide;
4-((7-(tert-butyl)-2,5-dioxo-3-(pyridin-2-ylmethyl)-1,2,3,5-tetrahydro-4H-thieno[3,2-e][1,4]diazepin-4-yl)methyl)-2-chloro-N-(5-methoxypyridin-2-yl)benzamide;
2-chloro-N-(4-methoxypyridin-2-yl)-4-((8-methyl-2,5-dioxo-3-(pyridin-2-ylmethyl)-1,2,3,5-tetrahydro-4H-pyrido[2,3-e][1,4]diazepin-4-yl)methyl)benzamide;
2-chloro-N-(4-methoxypyridin-2-yl)-4-((2-methyl-4,7-dioxo-6-(pyridin-2-ylmethyl)-2,6,7,8-tetrahydropyrazolo[3,4-e][1,4]diazepin-5(4H)-yl)methyl)benzamide;
2-chloro-4-((2-cyclopropyl-5,8-dioxo-6-(pyridin-2-ylmethyl)-2,5,6,8-tetrahydropyrazolo[4,3-e][1,4]diazepin-7(4H)-yl)methyl)-N-(4-methoxypyridin-2-yl)benzamide;
2-chloro-4-((2-cyclopropyl-5,8-dioxo-6-(pyridin-2-ylmethyl)-2,5,6,8-tetrahydropyrazolo[4,3-e][1,4]diazepin-7(4H)-yl)methyl)-N-(5-methoxypyridin-2-yl)benzamide;
2-chloro-N-(4-methoxypyridin-2-yl)-4-((2-methyl-5,8-dioxo-6-(pyridin-2-ylmethyl)-4,5,6,8-tetrahydro-7H-thiazolo[4,5-e][1,4]diazepin-7-yl)methyl)benzamide;
2-chloro-4-((2-cyclopropyl-5,8-dioxo-6-(pyridin-2-ylmethyl)-4,5,6,8-tetrahydro-7H-thiazolo[4,5-e][1,4]diazepin-7-yl)methyl)-N-(pyridin-2-yl)benzamide;
4-((2-(tert-butyl)-5,8-dioxo-6-(pyridin-2-ylmethyl)-4,5,6,8-tetrahydro-7H-thiazolo[4,5-e][1,4]diazepin-711)methyl)-2-chloro-N-(pyridin-2-yl)benzamide;
4-((2-(tert-butyl)-5,8-dioxo-6-(pyridin-2-ylmethyl)-4,5,6,8-tetrahydro-7H-thiazolo[4,5-e][1,4]diazepin-711)methyl)-2-chloro-N-(4-methoxypyridin-2-yl)benzamide;
2-chloro-4-((2-cyclopropyl-5,8-dioxo-6-(pyridin-2-ylmethyl)-4,5,6,8-tetrahydro-7H-thiazolo[4,5-e][1,4]diazepin-7-yl)methyl)-N-(4-methoxypyridin-2-yl)benzamide;
2-chloro-4-((2-cyclopropyl-5,8-dioxo-6-(pyridin-2-ylmethyl)-4,5,6,8-tetrahydro-7H-thiazolo[4,5-e][1,4]diazepin-7-yl)methyl)-N-(5-methoxypyridin-2-yl)benzamide;
2-chloro-4-((4,7-dioxo-6-(pyridin-2-ylmethyl)-2,6,7,8-tetrahydropyrazolo[3,4-e][1,4]diazepin-5(4H)-yl)methyl)-N-(pyridin-2-yl)benzamide;
2-chloro-4-((4,7-dioxo-6-(pyridin-2-ylmethyl)-2,6,7,8-tetrahydropyrazolo[3,4-e][1,4]diazepin-5(4H)-yl)methyl)-N-(5-methoxypyridin-2-yl)benzamide;
2-chloro-4-((4,7-dioxo-6-(pyridin-2-ylmethyl)-2,6,7,8-tetrahydropyrazolo[3,4-e][1,4]diazepin-5(4H)-yl)methyl)-N-(4-methoxypyridin-2-yl)benzamide;
2-chloro-4-((7-chloro-2,5-dioxo-3-(pyridin-2-ylmethyl)-1,2,3,5-tetrahydro-4H-thieno[3,2-e][1,4]diazepin-4-yl)methyl)-N-(5-(trifluoromethyl)pyridin-2-yl)benzamide;
2-chloro-4-((7-cyclopropyl-2,5-dioxo-3-(pyridin-2-ylmethyl)-1,2,3,5-tetrahydro-4H-thieno[3,2-e][1,4]diazepin-4-yl)methyl)-N-(5-(trifluoromethyl)pyridin-2-yl)benzamide;
2-chloro-4-((1-methyl-5,8-dioxo-6-(pyridin-2-ylmethyl)-4,5,6,8-tetrahydroimidazo[4,5-e][1,4]diazepin-7(1H)-yl)methyl)-N-(pyridin-2-yl)benzamide;
2-chloro-4-((7-chloro-2,5-dioxo-3-(pyridin-2-ylmethyl)-1,2,3,5-tetrahydro-4H-thieno[3,2-e][1,4]diazepin-4-yl)methyl)-N-(4-methoxypyridin-2-yl)benzamide;
2-chloro-N-(4-methoxypyridin-2-yl)-4-((1-methyl-5,8-dioxo-6-(pyridin-2-ylmethyl)-4,5,6,8-tetrahydroimidazo[4,5-e][1,4]diazepin-7(1H)-yl)methyl)benzamide;
2-chloro-4-((2-cyclopropyl-5,8-dioxo-6-(pyridin-2-ylmethyl)-4,5,6,8-tetrahydro-7H-thiazolo[4,5-e][1,4]diazepin-7-yl)methyl)-N-(5-(trifluoromethyl)pyridin-2-yl)benzamide;
2-chloro-4-((1-methyl-5,8-dioxo-6-(pyridin-2-ylmethyl)-4,5,6,8-tetrahydroimidazo[4,5-e][1,4]diazepin-7(1H)-yl)methyl)-N-(5-(trifluoromethyl)pyridin-2-yl)benzamide;
ethyl 6-(2-chloro-4-((7-chloro-2,5-dioxo-3-(pyridin-2-ylmethyl)-1,2,3,5-tetrahydro-4H-thieno[3,2-e][1,4]diazepin-4-yl)methyl)benzamido)nicotinate;
methyl 6-(2-chloro-4-((7-chloro-2,5-dioxo-3-(pyridin-2-ylmethyl)-1,2,3,5-tetrahydro-4H-thieno[3,2-e][1,4]diazepin-4-yl)methyl)benzamido)nicotinate;
(R)-4-((7-bromo-2,5-dioxo-3-(pyridin-2-ylmethyl)-1,2,3,5-tetrahydro-4H-thieno[3,2-e][1,4]diazepin-4-yl)methyl)-2-chloro-N-(5-(trifluoromethyl)pyridin-2-yl)benzamide;
2-chloro-4-((8-chloro-2,5-dioxo-3-(pyridin-2-ylmethyl)-1,2,3,5-tetrahydro-4H-pyrido[3,2-e][1,4]diazepin-4-yl)methyl)-N-(pyridin-2-yl)benzamide;
2-chloro-4-((8-chloro-2,5-dioxo-3-(pyridin-2-ylmethyl)-1,2,3,5-tetrahydro-4H-pyrido[3,2-e][1,4]diazepin-4-yl)methyl)-N-(4-methoxypyridin-2-yl)benzamide;
2-chloro-4-((8-chloro-2,5-dioxo-3-(pyridin-2-ylmethyl)-1,2,3,5-tetrahydro-4H-pyrido[3,2-e][1,4]diazepin-4-yl)methyl)-N-(5-(trifluoromethyl)pyridin-2-yl)benzamide;
4-((7-bromo-2,5-dioxo-3-(pyridin-2-ylmethyl)-1,2,3,5-tetrahydro-4H-thieno[3,2-e][1,4]diazepin-4-yl)methyl)-2-chloro-N-(pyridin-2-yl)benzamide;
2-chloro-4-((7-chloro-2,5-dioxo-3-(pyridin-2-ylmethyl)-1,2,3,5-tetrahydro-4H-thieno[3,2-e][1,4]diazepin-4-yl)methyl)-N-(4-methoxy-5-(trifluoromethyl)pyridin-2-yl)benzamide;
2-chloro-4-((7-chloro-2,5-dioxo-3-(pyridin-2-ylmethyl)-1,2,3,5-tetrahydro-4H-thieno[3,2-e][1,4]diazepin-4-yl)methyl)-N-(4-methyl-5-(trifluoromethyl)pyridin-2-yl)benzamide;
2-chloro-4-((7-chloro-2,5-dioxo-3-(pyridin-2-ylmethyl)-1,2,3,5-tetrahydro-4H-thieno[3,2-e][1,4]diazepin-4-yl)methyl)-N-(5-methoxypyridazin-3-yl)benzamide;
2-chloro-4-((8-chloro-2,5-dioxo-3-(pyridin-2-ylmethyl)-1,2,3,5-tetrahydro-4H-pyrido[3,2-e][1,4]diazepin-4-yl)methyl)-N-(5-methoxypyridazin-3-yl)benzamide;
(S)-2-chloro-N-(4-methoxypyridin-2-yl)-4-((1-methyl-5,8-dioxo-6-(pyridin-2-ylmethyl)-4,5,6,8-tetrahydropyrazolo[4,3-e][1,4]diazepin-7(1H)-yl)methyl)benzamide;
(R)-2-chloro-4-((2,5-dioxo-3-(pyridin-2-ylmethyl)-1,2,3,5-tetrahydro-4H-thieno[3,2-e][1,4]diazepin-4-yl)methyl)-N-(5-methoxypyridazin-3-yl)benzamide;
2-chloro-4-((2,5-dioxo-3-(pyridin-2-ylmethyl)-8-(trifluoromethyl)-1,2,3,5-tetrahydro-4H-pyrido[3,2-e][1,4]diazepin-4-yl)methyl)-N-(5-methoxypyridazin-3-yl)benzamide;
(S)-2-chloro-4-((8-chloro-2,5-dioxo-3-(pyridin-2-ylmethyl)-1,2,3,5-tetrahydro-4H-pyrido[3,2-e][1,4]diazepin-4-yl)methyl)-N-(4-methoxypyridin-2-yl)benzamide;
(R)-2-chloro-4-((8-chloro-2,5-dioxo-3-(pyridin-2-ylmethyl)-1,2,3,5-tetrahydro-4H-pyrido[3,2-e][1,4]diazepin-4-yl)methyl)-N-(5-(trifluoromethyl)pyridin-2-yl)benzamide;, or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof.