Patent ID: 11873304
Assignee: INCYTE CORPORATION
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 36:
37. The method of claim 2, wherein the compound is selected from:
3-(5-Amino-2-(hydroxy(phenyl)methyl)-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)benzonitrile;
3-(5-Amino-2-benzyl-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)benzonitrile;
3-(5-Amino-2-(pyridin-2-ylmethyl)-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)benzonitrile;
3-(5-Amino-2-(cyclohexylmethyl)-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)benzonitrile;
3-(5-Amino-2-(3-(1-methyl-1H-pyrazol-4-yl)benzyl)-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)benzonitrile;
3-(5-Amino-2-((2-oxopyrrolidin-1-yl)methyl)-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)benzonitrile;
3-(5-Amino-2-((1-methyl-1H-imidazol-2-yl)methyl)-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)benzonitrile;
3-(5-Amino-2-(amino(phenyl)methyl)-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)benzonitrile;
3-(5-Amino-2-benzyl-8-(hydroxymethyl)-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)benzonitrile;
3-(5-Amino-2-(phenylamino)-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)benzonitrile;
5-Amino-7-(3-cyanophenyl)-N-ethyl-[1,2,4]triazolo[1,5-c]pyrimidine-2-carboxamide;
3-(5-Amino-2-((2,6-difluorophenyl)(hydroxy)methyl)-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)-2-methylbenzonitrile;
3-(5-Amino-2-((2,6-difluorophenyl)(hydroxy)methyl)-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)-2-fluorobenzonitrile;
5-Amino-7-(3-cyano-2-fluorophenyl)-2-((2,6-difluorophenyl)(hydroxy)methyl)-[1,2,4]triazolo[1,5-c]pyrimidine-8-carbonitrile;
3-(5-Amino-2-((2-fluoro-6-(((1-methyl-2-oxopyrrolidin-3-yl)amino)methyl)phenyl)(hydroxy)methyl)-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)-2-fluorobenzonitrile;
3-(5-Amino-2-((2-fluoro-6-((6-methyl-5-oxo-2,6-diazaspiro[3.4]octan-2-yl)methyl)phenyl)(hydroxy)methyl)-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)-2-fluorobenzonitrile;
3-(5-Amino-2-((2-((ethyl(2-oxopyrrolidin-3-yl)amino)methyl)-6-fluorophenyl)(hydroxy)methyl)-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)-2-fluorobenzonitrile;
2-(3-((2-((5-Amino-7-(3-cyano-2-fluorophenyl)-[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)methyl)-3-fluorobenzyl)amino)-2-oxopyrrolidin-1-yl)acetic acid;
3-(5-Amino-2-(2-fluoro-6-(((2-oxotetrahydrofuran-3-yl)amino)methyl)benzyl)-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)-2-fluorobenzonitrile;
3-(5-Amino-2-(2-fluoro-6-(((2-oxopyrrolidin-3-yl)amino)methyl)benzyl)-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)-2-fluorobenzonitrile;
3-(2-(2-((3-(2H-Tetrazol-5-yl)pyrrolidin-1-yl)methyl)-6-fluorobenzyl)-5-amino-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)-2-fluorobenzonitrile;
3-(5-Amino-2-(2-(((1-ethyl-2-oxopyrrolidin-3-yl)amino)methyl)-6-fluorobenzyl)-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)-2-fluorobenzonitrile;
N-(1-(2-((5-Amino-7-(3-cyano-2-fluorophenyl)-[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)methyl)-3-fluorobenzyl)pyrrolidin-3-yl)acetamide;
3-(2-(2-((2-(2H-Tetrazol-5-yl)pyrrolidin-1-yl)methyl)-6-fluorobenzyl)-5-amino-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)-2-fluorobenzonitrile;
1-(2-((5-Amino-7-(3-cyano-2-fluorophenyl)-[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)methyl)-3-fluorobenzyl)pyrrolidine-3-carbonitrile;
3-(5-Amino-2-(2-fluoro-6-((6-methyl-5-oxo-2,6-diazaspiro[3.4]octan-2-yl)methyl)benzyl)-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)-2-fluorobenzonitrile;
3-(5-Amino-2-(2-fluoro-6-(((1-methyl-2-oxopyrrolidin-3-yl)amino)methyl)benzyl)-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)-2-fluorobenzonitrile;
2-(3-((2-((5-Amino-7-(3-cyano-2-fluorophenyl)-[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)methyl)-3-fluorobenzyl)(ethyl)amino)-2-oxopyrrolidin-1-yl)acetic acid;
3-(5-Amino-2-(2-((ethyl(1-methyl-2-oxopyrrolidin-3-yl)amino)methyl)-6-fluorobenzyl)-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)-2-fluorobenzonitrile;
3-(5-Amino-2-(2-((ethyl(2-oxopyrrolidin-3-yl)amino)methyl)-6-fluorobenzyl)-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)-2-fluorobenzonitrile;
3-(5-Amino-2-(((6-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-yl)methyl)amino)-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)-2-fluorobenzonitrile; and
3-(5-Amino-2-(((6-(1-(2-morpholinoethyl)-1H-pyrazol-4-yl)pyridin-2-yl)methyl)amino)-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)-2-fluorobenzonitrile,
or a pharmaceutically acceptable salt of any of the aforementioned.