Patent ID: 11872371
Assignee: THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
Field: Medical technology (Instruments)
Classification: CPC A | IPC A

Claim 12:
13. An implantable system for monitoring, diagnosing and/or treating a disease or disorder in a subject, wherein the system comprises
one or more pairs of implantable electrodes for recording nerve activity from the subject, wherein the nerve activity consists of vagus nerve activity,
an implantable interface to capture the nerve activity,
an implantable digitizer to digitize the nerve activity,
an implantable processor for processing the digitized nerve activity,
an implantable rechargeable or replaceable battery; and
a wireless external device interface for inputting biological signals to the processor and for outputting signals from the processor;
wherein the system is programmed to correlate a plurality of vagus nerve activity measurements from the subject with a plurality of concurrent measurements of levels of one or more cytokines and/or glucose in the blood of the subject to obtain a functional relationship between blood cytokine levels and/or blood glucose levels and vagus nerve activity recorded from the subject; and to provide real-time diagnostic, treatment or monitoring recommendations by-analyzing the subject's real-time vagus nerve activity in accordance with the previously obtained functional relationship, and
wherein the treatment consists of one or more of administering insulin, glucose, glucagon, a cytokine antagonist or a cytokine inhibitor to the subject, and applying acoustic energy stimulus to the subject.