Patent ID: 11858929
Assignee: CORNELL UNIVERSITY
Field: Organic fine chemistry (Chemistry)
Classification: CPC C  A | IPC C

Claim 0:
1. A compound of Formula I:, or tautomer thereof, and/or a pharmaceutically acceptable salt thereof; wherein
A1 is CH;
A2 is N;
A3 and A4 are each independently CH, CR3 or N;
A5 and A6 are each independently CH or CR3;
q is 1;
R1 is phenyl, 5-membered heteroaryl or 6-membered heteroaryl, wherein the phenyl, 5-membered heteroaryl or 6-membered heteroaryl is optionally substituted with 1 to 3R6;
L2 is selected from the group consisting of —NHC(O)—, and —NHCH2;
R2 is 6- to 10-membered aryl or 5- to 10-membered heteroaryl; wherein the 6- to 10-membered aryl or 5- to 10-membered heteroaryl is optionally substituted with 1 to 4R4, wherein each R4 is independently selected from the group consisting of lower alkyl, lower haloalkyl, phenyl (optionally substituted with lower alkyl, halo or lower haloalkyl, or —OH), —OH, —OR7, —SH, —SR7, —NR10R10, halo, cyano, nitro, —COH, —COR7, —CO2H, —CO2R7, —CONR10R10, —OCOR7, —OCO2R7, —OCONR10R10, —NR10COR7, —NR10CO2R7, —SOR7, —SO2R7, —SO2NR10R10, and —NR10SO2R7;
each R3 is independently selected from the group consisting of lower alkyl, lower haloalkyl, —OH, —OR′, —SH, —SR′, —NR10R10, halo, cyano, nitro, —COH, —COR7, —CO2H, —CO2R7, —CONR10R10, —OCOR7, —OCO2R7, —OCONR10R10, —NR10COR10, —NR10CO2R10, —SOR7, —SO2R7, —SO2NR10R10, and —NR10SO2R7;
each R6 is independently selected from the group consisting of halo, cyano, lower alkyl and lower haloalkyl;
each R7 is independently lower alkyl or lower haloalkyl; and
each R10 is independently hydrogen or lower alkyl, or two R10 together with the atom(s) attached thereto form a 4- to 6-membered ring.