Patent ID: 11912776
Assignee: PFIZER INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 13:
14. The method of claim 13, wherein the extracellular ligand-binding domain comprises a single chain Fv fragment (scFv) comprising
(i) a VH region comprising a VH CDR1, a VH CDR2, and a VH CDR3, wherein the VH CDR1 comprises the amino acid sequence shown in SEQ ID NO: 150, 151, or 152; the VH CDR2 comprises the amino acid sequence shown in SEQ ID NO: 153 or 154; the VH CDR3 comprises the amino acid sequence shown in SEQ ID NO: 155, and
a VL region comprising a VL CDR1, a VL CDR2, and a VL CDR3, wherein the VL CDR1 comprises the amino acid sequence shown in SEQ ID NO: 209; the VL CDR2 comprises the amino acid sequence shown in SEQ ID NO: 221; the VL CDR3 comprises the amino acid sequence shown in SEQ ID NO: 222.