Patent ID: 11866465
Assignee: JUNO THERAPEUTICS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 49:
50. A multimerized oligomeric particle reagent, comprising an oligomer of between 2,000 and 3,000 tetramers of a streptavidin mutein molecule, a first receptor-binding agent comprising a first streptavidin-binding peptide and an anti-CD3 Fab, and a second receptor-binding agent comprising a second streptavidin-binding peptide and an anti-CD28 Fab, wherein:
the streptavidin mutein molecule comprises the sequence of amino acids set forth in SEQ ID NO: 6;
the amino acid sequence of the first streptavidin-binding peptide is set forth in SEQ ID NO: 16, and the first streptavidin-binding peptide is reversibly bound to one or more binding sites of a streptavidin mutein molecule of the oligomer; and
the amino acid sequence of the second streptavidin-binding peptide is set forth in SEQ ID NO: 16, and the second streptavidin-binding peptide is reversibly bound to one or more binding sites of a streptavidin mutein molecule of the oligomer.