Patent ID: 11919849
Assignee: P2 SCIENCE, INC.
Field: Organic fine chemistry (Chemistry)
Classification: CPC C | IPC C

Claim 0:
1. A method of making a compound according to Formula 1:, wherein n is an integer from 0-5; X is O or S; R3 is selected from H, C1-6alkyl, and C2-10acyl; and each of R1, R2, R4, R5, and R6 are independently selected from H and C1-10alkyl, optionally wherein each of said C1-10alkyl is further substituted by a group selected from C1-6alkyl, hydroxy, C1-6alkoxy, formyl, and C2-10acyl, or wherein R1 and R2, and/or R4 and R5, and/or R2 and R5, can be taken together to form a C3-8carbocyclic ring, wherein such ring is optionally substituted by a group selected from C1-6alkyl, hydroxy, C1-6alkoxy, formyl, and C2-10acyl;
wherein the method comprises the steps of (a) treating the compound of Formula 2,, wherein n, X, and each of R1, R2, R3, R4, R5, and R6 are as defined for Formula 1, and
wherein Z is selected from vinyl (—CH═CH2) and isopropenyl (—C(CH3)═CH2);, with ozone to form an ozonide mixture, and (b) quenching the ozonide mixture with an alpha-hydroxysulfinic acid or alpha-hydroxysulfinic acid salt quenching agent to yield the compound of Formula 1.