Patent ID: 11920199
Assignee: THE HOSPITAL FOR SICK CHILDREN
Field: Measurement (Instruments)
Classification: CPC C  G | IPC C  G

Claim 0:
1. A method comprising:
(a) (i) hybridizing a nucleic acid probe to a polynucleic acid from a human subject, or (ii) synthesizing a nucleic acid product from a polynucleic acid from a human subject, wherein the human subject has a disease associated with a developmental disorder selected from the group consisting of Autism Spectrum Disorder (ASD), Asperger Syndrome, Rett Syndrome, and Childhood Disintegrative Disorder; and
(b) detecting a genetic variation in the polynucleic acid by PCR, sequencing, nucleic acid hybridization, microarray analysis or northern blot or a combination thereof, wherein the genetic variation is a copy number variant (CNV), wherein the CNV is in a DAGLA gene; wherein the CNV is a loss of SEQ ID NO: 53 or a complement thereof.