Patent ID: 11946896
Assignee: LOUISIANA TECH RESEARCH CORPORATION
Field: Measurement (Instruments)
Classification: CPC G  A | IPC G

Claim 12:
13. A method of detecting GABA in a brain cell mass comprising the steps of:
(a) inserting a probe body into the brain cell mass, the probe comprising:
(i) a Glu micro-sensor located on the probe body, the Glu micro-sensor including at least one Pt electrode having a surface modification with GOx and a binding matrix;
(ii) a GABA micro-sensor located on the probe body, the GABA micro-sensor including at least one Pt electrode having a surface modification with GABASE, GOx, and the binding matrix, the GABA and Glu micro-sensors being positioned no further than 250 um apart on the probe body;
(iii) a sentinel site located on the probe body, the sentinel site including at least one Pt electrode having the binding matrix but no GOx or GABASE; and
(iv) wherein the Pt electrodes each include (1) a surface area of less than 35,000 um2, and (2) a connecting lead attached thereto and extending along the probe body;

(b) receiving at a potentiostat electrical signals from the connecting leads and determining an electro-potential difference between the GABA micro-sensor and Glu micro-sensor.