Patent ID: 11931347
Assignee: MINERVA BIOTECHNOLOGIES CORPORATION
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C  G | IPC A  C  G

Claim 18:
19. A compound of Formula 5, Formula 6, Formula 7, or Formula 9,, wherein,
R1 is H, optionally substituted C1-C6 alkyl or an optionally substituted C3-C8 cycloalkyl;
R2 is hydrogen, C1-C6 alkoxy, trifluoromethyl, halogen, methylcarboxy, ethylcarboxy, optionally substituted C1-C6 alkyl, —OH, —SH, —NH2, —N3, —CN, —NO2, —CHO, —COOH, —CONH2, —C(═NH)NH2, or —SO3H;
G1 is —(CH2)n—, —CH═CH—, or —C3-C7 cycloalkylene-CH2—;
Z2 is a bond, —NH—, —O—, —S—, —CH(CH3)—, —(CH2)n—, —CH═CH—, —CO—, —SO—, —SO2—, —C(═NH)—, —CH2NH(CO)—, —CH2NH(CO)O—, —CH2NH(CO)NH—, —(CH2)pNH(CO)—, —(CH2)pNH(CO)O—, —(CH2)pNH(CO)NH—, —C3-C7 cycloalkylene-NH(CO)—, —C3-C7 cycloalkylene-CH2NH(CO)O—, —C3-C7 cycloalkylene-NH(CO)NH—, —N(CH2CH2C6H4)—, or optionally substituted C6-C12 arylene;
R5 is H, C1-C6 alkyl, or 2-phenylethyl;
R4 is H, optionally substituted C1-C9 alkyl, optionally substituted C2-C6 alkenyl; optionally substituted C6-C12 aryl, optionally substituted C1-C9 heteroaryl with 1 to 4 ring atoms independently selected from N, S, and O, optionally substituted C7-C15 arylalkyl, optionally substituted C3-C7 cycloalkyl, —(CH2)p—NH(CO)O—(C1-C6 alkyl), —CH2O(CH2)p—NH(CO)O—(C1-C6) alkyl, —(CH2)p—NHCO—(CH2)n—NH(CO)O—C1-C6 alkyl), —NH(CO)O-tert-butyl, —O-tert-butyl, or -tert-butyl;
each n is independently selected from 1-8; each p is independently elected from 1-9;
where “substituted” means substituted with one or more substituents independently selected from halogen, trifluoromethyl, methylcarboxy, ethylcarboxy, C1-C6 alkoxy, C1-C6 alkyl, —OH, —SH, —NH2, —N3, —CN, —NO2, —CHO, —COOH, —CONH2, —C(═NH)NH2, or —SO3H;, wherein,
R1 is H, C1-C6 alkyl, or optionally substituted C3-C8 cycloalkyl,
R2 is hydrogen, C1-C6 alkoxy, trifluoromethyl, halogen, methylcarboxy, ethylcarboxy, optionally substituted C1-C6 alkyl, —OH, —SH, —NH2, —N3, —CN, —NO2, —CHO, —COOH, —CONH2, —C(═NH)NH2, or —SO3H;
G1 is —(CH2)n—, —CH═CH—, or —C3-C7 cycloalkylene-CH2—;
Z2 is a bond, —NH—, —O—, —S—, —CH(CH3)—, —(CH2)n—, —CH═CH—, —CO—, —SO—, —SO2—, —C(═NH)—, —CH2NH(CO)—, —CH2NH(CO)O—, —CH2NH(CO)NH—, —(CH2)pNH(CO)—, —(CH2)pNH(CO)O—, —(CH2)pNH(CO)NH—, —C3-C7 cycloalkylene-NH(CO)—, —C3-C7 cycloalkylene-CH2NH(CO)O—, —C3-C7 cycloalkylene-NH(CO)NH—, or —N(CH2CH2C6H5)—;
R5 is H, C1-C6 alkyl, or 2-phenylethyl;
X is H, or C1-C3 alkyl;
each n is independently selected from 1-8; each p is independently selected from 1-9;
where “substituted” means substituted with one or more substituents independently selected from halogen, trifluoromethyl, methylcarboxy, ethylcarboxy, C1-C6 alkoxy, C1-C6 alkyl, —OH, —SH, —NH2, —N3, —CN, —NO2, —CHO, —COOH, —CONH2, —C(═NH)NH2, or —SO3H;, wherein,
R1 is H, C1-C6 alkyl, optionally substituted C2-C6 alkenyl, optionally substituted C1-C6 alkoxy, optionally substituted C1-C9 heteroaryl with 1 to 4 ring atoms independently selected from N, S, and O, optionally substituted C7-C15 arylalkyl, optionally substituted C2-C15 heteroarylalkyl with 1 to 4 ring atoms independently selected from N, S, and O, optionally substituted arylalkenyl, an optionally substituted C3-C8 cycloalkyl, or optionally substituted C4-C8 cycloalkylalkyl;
R2 is hydrogen, C1-C6 alkoxy, trifluoromethyl, halogen, methylcarboxy, ethylcarboxy, optionally substititued C1-C6 alkyl, —OH, —SH, —NH2, —N3, —CN, —NO2, —CHO, —COOH, —CONH2, —C(═NH)NH2, or —SO3H;
G2 is a bond, —(CH2)n—, —CH═CH—, —CH2NH(CO)—, —CH2NH(CO)O—, —CH2NH(CO)NH—, —(CH2)nNH(CO)—, —(CH2)nNH(CO)O—, —(CH2)mNH(CO)NH—, or —C3-C7 cycloalkyl—,
Z2 is a bond, —NH, —O—, —S—, —CH(CH3)—, —(CH2)n—, —CH═CH—, —CO—, —SO—, —SO2— or —C(═NH)—, —CH2NH(CO)—, —CH2NH(CO)O—, —CH2NH(CO)NH—, —(CH2)pNH(CO)—, —(CH2)pNH(CO)O—, —(CH2)pNH(CO)NH—, —C3-C7 cycloalkylene-NH(CO)—, —C3-C7 cycloalkylene-CH2NH(CO)O—, —C3-C7 cycloalkylene-NH(CO)NH—, or —N(CH2CH2C6H5)—;
R5 is H, C1-C6 alkyl, or 2-phenylethyl;
X is H, or C1-C3 alkyl;
each m is independently selected from 1-5; each n is independently selected from 1-8; each p is independently selected from 1-9;
where “substituted” means substituted with one or more substituents independently selected from halogen, trifluoromethyl, methylcarboxy, ethylcarboxy, C1-C6 alkoxy, C1-C6 alkyl, —OH, —SH, —NH2, -N3, —CN, —NO2, —CHO, —COOH, —CONH2, —C(═NH)NH2, or —SO3H;, wherein,
R1 is H, optionally substituted C1-C6 alkyl, optionally substituted C2-C6 alkenyl, optionally substituted C1-C6 alkoxy, optionally substituted C6-C12 aryl, optionally substituted C1-C9 heteroaryl with 1 to 4 ring atoms independently selected from N, S, and O, optionally substituted C7-C15 arylalkyl, optionally substituted C2-C15 heteroarylalkyl with 1 to 4 ring atoms independently selected from N, S, and O, optionally substituted C7-C15 arylalkenyl, optionally substituted C3-C8 cycloalkyl, or an optionally substituted C4-C8 cycloalkylalkyl;
R2 is hydrogen, C1-C6 alkoxy, trifluoromethyl, halogen, methylcarboxy, ethylcarboxy, optionally substituted C1-C6 alkyl, —OH, —SH, —NH2, —N3, —CN, —NO2, —CHO, —COOH, —CONH2, —C(═NH)NH2, or —SO3H;
R5 is H, C1-C6 alkyl, or 2-phenylethyl;
X is H, or C1-C3 alkyl;
Z2 is a bond, —NH—, —O—, —S—, —CH(CH3)—, —(CH2)n—, —CH═CH—, —CO—, —SO—, —SO2— or —C(═NH)—, —CH2NH(CO)—, —CH2NH(CO)O—, —CH2NH(CO)NH—, —(CH2)nNH(CO)—, —(CH2)nNH(CO)O—, —(CH2)mNH(CO)NH—, —C3-C7 cycloalkylene-NH(CO)—, —C3-C7 cycloalkylene-CH2NH(CO)O—, —C3-C7 cycloalkylene-NH(CO)NH—, or —N(CH2CH2C6H4)—,
each p is independently selected from 1-5; each n is independently selected from 1-8;

where “substituted” means substituted with one or more substituents independently selected from halogen, trifluoromethyl, methylcarboxy, ethylcarboxy, C1-C6 alkoxy, C1-C6 alkyl, —OH, —SH, —NH2, —N3, —CN, —NO2, —CHO, —COOH, —CONH2, —C(═NH)NH2, or —SO3H.