Patent ID: 11884729
Assignee: APITBIO, INC
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C  G | IPC A  C

Claim 4:
5. The antibody or antigen-binding fragment thereof of claim 1,
wherein the VH comprises an amino acid sequence which is at least about 80%, at least about 85%, at least about 90%, at least about 95%, at least about 96%, at least about 97%, at least about 98%, at least about 99%, or about 100% identical to the amino acid sequence set forth as EVQLVESGGGVVQPGGSLRLSCAASGFTESREGMHWVRQAPGKGLEWVAFSNEGSNKYYADSVKGRFTSRDNSANTLY LQMNSLRAEDTAVYYCARGRAYGSGSLFDPWGQGTLVTVSS(SEQ ID NO: 23) and wherein the VL comprises an amino acid sequence which is at least about 80%, at least about 85%, at least about 90%, at least about 95%, at least about 96%, at least about 97%, at least about 98%, at least about 99%, or about 100% identical to the amino acid sequence set forth as DQLTQSPSSLSASVGDRVTTCRASRTSSYVNWYRQRPGKAPESLIYAASNLHSGVPSRFSGSGSGTDFTLTSSLQP EDFATYYCQQSIGRGPVTFGQGTKLEIK (SEQ ID NO: 24);
wherein the VH comprises an amino acid sequence which is at least about 80%, at least about 85%, at least about 90%, at least about 95%, at least about 96%, at least about 97%, at least about 98%, at least about 99%, or about 100% identical to the amino acid sequence set forth as EVQLVESGGGVVQPGGSLRLSCAASGFTESREGMHWVRQAPGKGLEWVAFSNEGSNKYYADSVKGRFTSRDNSANTLY LQMNSLRAEDTAVYYCARGRAYGSGSLFDPWGQGTLVTVSS (SEQ ID NO: 27) and wherein the VL, comprises an amino acid sequence which is at least about 80%, at least about 85%, at least about 90%, at least about 95%, at least about 96%, at least about 97%, at least about 98%, at least about 99%, or about 100% identical to the amino acid sequence set forth as DQLTQSPSSLSASVGDRVTTCRASRTSSYVNWYRQRPGKAPESLIYAASNLHSGVPSRFSGSGSGTDFTLTSSLQP EDFATYYCQQAGFYSPWTFGQGTKLEIK (SEQ ID NO: 28);
wherein the VH comprises an amino acid sequence which is at least about 80%, at least about 85%, at least about 90%, at least about 95%, at least about 96%, at least about 97%, at least about 98%, at least about 99%, or about 100% identical to the amino acid sequence set forth as EVQLVESGGGVVQPGGSLRLSCAASGFTESREGMHWVRQAPGKGLEWVAFSNEGSNKYYADSVKGRFTSRDNSANTLY LQMNSLRAEDTAVYYCARGRAYGSGSLFDPWGQGTLVTVSS (SEQ ID NO: 25) and wherein the VL, comprises an amino acid sequence which is at least about 80%, at least about 85%, at least about 90%, at least about 95%, at least about 96%, at least about 97%, at least about 98%, at least about 99%, or about 100% identical to the amino acid sequence set forth as DQLTQSPSSLSASVGDRVTTCRASRTSSYVNWYRQRPGKAPESLIYAASNLHSGVPSRFSGSGSGTDFTLTSSLQP EDFATYYCQQAGFYTPWTFGQGTKLEIK (SEQ ID NO: 26);
wherein the VH comprises an amino acid sequence which is at least about 80%, at least about 85%, at least about 90%, at least about 95%, at least about 96%, at least about 97%, at least about 98%, at least about 99%, or about 100% identical to the amino acid sequence set forth as EVQLVESGGGVVQPGGSLRLSCAASGFTESREGMHWVRQAPGKGLEWVAFSNEGSNKYYADSVKGRFTSRDNSANTLY LQMNSLRAEDTAVYYCARGRAYGSGSLFDPWGQGTLVTVSS (SEQ ID NO: 29) and wherein the VL comprises an amino acid sequence which is at least about 80%, at least about 85%, at least about 90%, at least about 95%, at least about 96%, at least about 97%, at least about 98%, at least about 99%, or about 100% identical to the amino acid sequence set forth as DQLTQSPSSLSASVGDRVTTCRASRTSSYVNWYRQRPGKAPESLIYAASNLHSGVPSRFSGSGSGTDFTLTSSLQP EDFATYYCQQSLHFYPWTFGQGTKLEIK (SEQ ID NO: 30); or
wherein the VH comprises an amino acid sequence which is at least about 80%, at least about 85%, at least about 90%, at least about 95%, at least about 96%, at least about 97%, at least about 98%, at least about 99%, or about 100% identical to the amino acid sequence set forth as EVQLVESGGGVVQPGGSLRLSCAASGFTESREGMHWVRQAPGKGLEWVAFSNEGSNKYYADSVKGRFTSRDNSANTLY LQMNSLRAEDTAVYYCARGRAYGSGSLFDPWGQGTLVTVSS (SEQ ID NO: 31) and wherein the VL, comprises an amino acid sequence which is at least about 80%, at least about 85%, at least about 90%, at least about 95%, at least about 96%, at least about 97%, at least about 98%, at least about 99%, or about 100% identical to the amino acid sequence set forth as DQLTQSPSSLSASVGDRVTTCRASRTSSYVNWYRQRPGKAPESLIYAASNLHSGVPSRFSGSGSGTDFTLTSSLQP EDFATYYC QQSLVWYPWTFGQGTKLEIK (SEQ ID NO: 32).