Patent ID: 11911515
Assignee: AMNEAL COMPLEX PRODUCTS RESEARCH LLC
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 16:
17. A gastroretentive dosage form comprising a core, and a permeable elastic membrane comprising at least one orifice and surrounding the core,
wherein the core comprises pyridostigmine or a pharmaceutically acceptable salt thereof, and a swellable water-soluble hydrophilic polymer,
wherein the permeable elastic membrane comprises a copolymer based on ethyl acrylate, methyl methacrylate, and trimethylammonioethyl methacrylate chloride,
wherein the copolymer is present in an amount of from about 70 wt % to about 95 wt %, based on the total weight of the membrane, and
wherein the dosage form provides an in vitro release of less than about 35 wt % of pyridostigmine or a pharmaceutically acceptable salt thereof within 2 hours of dissolution in 900 ml of a dissolution medium comprising pH 5 acetate buffer and about 150 mM of sodium chloride, measured using USP Apparatus I at about 100 rpm and about 37° C.