Patent ID: 11963960
Assignee: FLASH THERAPEUTICS, LLC
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 0:
1. A compound of Formula (I):, or a pharmaceutically acceptable salt thereof,
wherein
each Q, Y and Z are independently selected from N and C, and X is N or C—Ra;
provided that at least one of Q, X, Y and Z is N, and
each dashed bond is independently a single or double bond such that the bicycle they form is a heteroaryl;

R1 is, V is N or CH;
either T is N and R4′ is absent, or T is C;
R3 is selected from H, halo, CN, alkyl, alkoxy, hydroxy, acyloxy, amino, amido, cycloalkyl, heterocyclyl, carboxy, and alkoxycarbonyl;
R3′ is H or alkyl, or
R3 and R3′ taken together with the carbon atom to which they are attached form a cycloalkyl;
R4 is selected from H, halo, CN, alkyl, alkoxy, acyloxy, amino, and amido;
R4′ is H or alkyl;
R5 is H or alkyl;
either
a) W is N, R2 is absent, and A1 and A2 are each CH2; or
b) W is C, R2 is selected from H, halo, CN, alkyl, alkoxy, hydroxy, acyloxy, and amino, and A1 and A2 are each independently selected from CH2 and O;

Ra is selected from H, halo, CN and alkyl;
R9 is selected from H, halo, alkyl, alkoxy, hydroxy, acyloxy, and amino;
R10 is H or alkoxy;
R11 is aryloxy, heteroaryloxy, arylalkyl, alkoxycarbonyl, ureido or —C(O)-aryl; and
R12 is selected from H, halo, CN, alkyl, alkoxy, hydroxy, and acyloxy;
provided that either R3 is alkyl or R9 is halo.