Patent ID: 11965199
Assignee: SANOFI
Field: Biotechnology (Chemistry)
Classification: CPC C | IPC C

Claim 17:
18. A cell expressing:
(i) a heterologous CYP21A2 protein or a functional variant thereof;
(ii) at least one heterologous electron transfer system capable of transferring electrons to CYP21A2, wherein the at least one electron transfer system is selected from the group consisting of:
the combination of a flavodoxin reductase (Fpr) and an adrenotoxin;
the combination of a Fpr and the ferredoxin domain of an electron transfer domain (etpfd);
the combination of an adrenotoxin reductase homolog (Arh) and an adrenotoxin; and
the combination of an Arh and etpfd; and

(iii) one or more chaperones facilitating folding of CYP21A2.