Patent ID: 11866499
Assignee: JANSSEN BIOTECH, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 6:
7. An isolated bispecific anti-TMEFF2/anti-CD3 antibody or an antigen binding fragment thereof comprising a first domain that binds TMEFF2 and a second domain that binds CD3, wherein
a) the first domain comprises a HCDR1, a HCDR2, a HCDR3, a LCDR1, a LCDR2 and a LCDR3 of SEQ ID NOs: 10, 12, 15, 18, 20 and 86, respectively, and the second domain comprises a HCDR1, a HCDR2, a HCDR3, a LCDR1, a LCDR2 and a LCDR3 of SEQ ID NOs: 68, 69, 70, 71, 72 and 73, respectively;
b) the first domain comprises a VH of SEQ ID NO: 87 and a VL of SEQ ID NO: 88, and the second domain comprises a VH of SEQ ID NO: 74 and a VL of SEQ ID NO: 75; or
c) the bispecific anti-TMEFF2/anti-CD3 antibody or an antigen binding fragment thereof comprises a HC1 of SEQ ID NO: 91, a LC1 of SEQ ID NO: 92, a HC2 of SEQ ID NO: 78 and a LC2 of SEQ ID NO: 79.