Patent ID: 11858988
Assignee: JOHANNES GUTENBERG-UNIVERSITäT MAINZ
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 8:
9. The recombinant nucleic acid of claim 5 wherein the nucleic acid sequence is selected from the group consisting of:
(i) a nucleic acid sequence encoding a polypeptide chain of a single chain anti-CLDN6 antibody comprising a heavy chain of an antibody and a light chain of an antibody, said heavy chain comprising heavy chain HCDR1, HCDR2, and HCDR3 regions of SEQ ID NO: 34 and said light chain comprising light chain LCDR1, LCDR2, and LCDR3 regions of SEQ ID NO: 35,
wherein HCDR1 consists of amino acid sequence GYSFTGYT (SEQ ID NO: 47) identified within SEQ ID NO: 34, HCDR2 consists of amino acid sequence INPYNGGT (SEQ ID NO: 54) identified within SEQ ID NO: 34, and HCDR3 consists of amino acid sequence ARDYGYVLDY (SEQ ID NO: 55) identified within SEQ ID NO: 34,
wherein LCDR1 consists of amino acid sequence SSVSY (SEQ ID NO: 56) identified within SEQ ID NO: 35, LCDR2 consists of amino acid sequence STS (SEQ ID NO: 53) identified within SEQ ID NO: 35, and LCDR3 consists of amino acid sequence QQRSIYPPWT (SEQ ID NO: 57) identified within SEQ ID NO: 35;
(iii) a nucleic acid sequence encoding a polypeptide chain of a single chain anti-CLDN6 antibody comprising a heavy chain of an antibody and a light chain of an antibody, said heavy chain comprising heavy chain HCDR1, HCDR2, and HCDR3 regions of SEO ID NO: 38 and said light chain comprising light chain LCDR1, LCDR2, and LCDR3 regions of SEQ TD NO: 39,
wherein HCDR1 consists of amino acid sequence GYSFTGYT (SEO ID NO: 47) identified within SEQ ID NO: 38, HCDR2 consists of amino acid sequence INPYNGGI (SEO ID NO: 60) identified within SEO ID NO: 38, and HCDR3 consists of amino acid sequence ARDFGYVLDY (SE ID NO: 61) identified within SEO ID NO: 38,
wherein LCDR1 consists of amino acid sequence SSVSY (SEQ TD NO: 56) identified within SEQ TD NO: 39, LCDR2 consists of amino acid sequence STS (SEQ ID NO: 53) identified within SEQ ID NO: 39, and LCDR3 consists of amino acid sequence QQRSTYPPWT (SEQ TD NO: 62) identified within SEQ ID NO: 39; and
(iv) a nucleic acid sequence encoding a polypeptide chain of a single chain anti-CLDN6 antibody comprising a heavy chain of an antibody and a light chain of an antibody, said heavy chain comprising heavy chain HCDR1, HCDR2, and HCDR3 regions of SEQ ID NO: 40 and said light chain comprising light chain LCDR1, LCDR2, and LCDR3 regions of SEQ ID NO: 41,
wherein HCDR1 consists of amino acid sequence GYSFTGYT (SEQ ID NO: 47) identified within SEQ ID NO: 40, HCDR2 consists of amino acid sequence INPYNGGS (SEQ ID NO: 63) identified within SEQ ID NO: 40, and HCDR3 consists of amino acid sequence ARDYGYVFDY (SEQ ID NO: 64) identified within SEQ ID NO: 40,
wherein LCDR1 consists of amino acid sequence SSVNY (SEQ ID NO: 65) identified within SEQ ID NO: 41, LCDR2 consists of amino acid sequence STS (SEQ ID NO: 53) identified within SEQ ID NO: 41, and LCDR3 consists of amino acid sequence QQRNNYPPWT (SEQ ID NO: 66) identified within SEQ ID NO: 41.