Patent ID: 11903963
Assignee: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C  B  Y | IPC A  C

Claim 24:
25. A synthetic heparin analogue produced by the method of claim 15, comprising disaccharide repeating units of a glucuronic acid (Gch) and iduronic acid (IdoA) residue linked to a glucosamine (GlcN) residue modified by sulfation; comprising:
a 3-O-sulfated oligosaccharide comprising six to eight saccharide units;
at least one disaccharide unit sulfated by a 3-OST-3 enzyme;
at least one IdoA2S-GlcNS3S or at least one IdoA2S-GlcNS3 S6S disaccharide unit; and is devoid of a Gch-GlcNS3S6S disaccharide unit; and, at least one GlcNS6S disaccharide unit, and wherein the synthetic heparin analogue comprises a structure selected from the group consisting of:, wherein R is selected from the group consisting of —H, alkyl, substituted alkyl, aryl, and substituted aryl.