Patent ID: 11904287
Assignee: THE PROCTER & GAMBLE COMPANY
Field: Pharmaceuticals (Chemistry)
Classification: CPC B  C  A  D | IPC B  C

Claim 0:
1. A population of capsules, the capsules comprising:
an oil-based core comprising a benefit agent, and a substantially inorganic shell surrounding the core, wherein the shell comprises a first shell component comprising a condensed layer comprising a condensation of a precursor, wherein the precursor comprises at least one compound of Formula (I) or Formula (II):

(MvOzYn)w  (Formula I),

where M is one or more of silicon, titanium and aluminum, v is the valence number of M and is 3 or 4, z is from 0.5 to 1.6, each Y is independently selected from —OH, —OR2, halo,, , —NH2, —NHR2, —N(R2)2, and, , wherein R2 is a C1 to C20 alkyl, C1 to C20 alkylene, C6 to C22 aryl, or a 5-12 membered heteroaryl comprising from 1 to 3 ring heteroatoms selected from O, N, and S, R3 is a H, C1 to C20 alkyl, C1 to C20 alkylene, C6 to C22 aryl, or a 5-12 membered heteroaryl comprising from 1 to 3 ring heteroatoms selected from O, N, and S, n is from 0.7 to (v-1), and w is from 2 to 2000; or

(MvOzYnR1p)w  (Formula II),

where M is one or more of silicon, titanium and aluminum, v is the valence number of M and is 3 or 4, z is from 0.5 to 1.6, each Y is independently selected from —OH, —OR2, halo,, , —NH2, —NHR2, —N(R2)2,, , wherein R2 is selected from a C1 to C20 alkyl, C1 to C20 alkylene, C6 to C22 aryl, or a 5-12 membered heteroaryl comprising from 1 to 3 ring heteroatoms selected from O, N, and S, R3 is a H, C1 to C20 alkyl, C1 to C20 alkylene, C6 to C22 aryl, or a 5-12 membered heteroaryl comprising from 1 to 3 ring heteroatoms selected from O, N, and S, n is from 0 to (v-1), each R1 is independently selected from a C1 to C30 alkyl, a C1 to C30 alkylene, a C1 to C30 alkyl substituted with one or more of a halogen, —OCF3, —NO2, —CN, —NC, —OH, —OCN, —NCO, alkoxy, epoxy, amino, mercapto, acryloyl, CO2H, CO2alkyl, aryl, and heteroaryl, or a C1 to C30 alkylene substituted with one or more of a halogen, —OCF3, —NO2, —CN, —NC, —OH, —OCN, —NCO, alkoxy, epoxy, amino, mercapto, acryloyl, CO2H, CO2alkyl, aryl, and heteroaryl, p is present in an amount up to pmax, and w is from 2 to 2000;
wherein pmax=60/[9*Mw(R1)+8], where Mw(R1) is the molecular weight of the R1 group;
wherein the first shell component comprises up to 5 wt % of organic content;
wherein said population has a mean volume weighted capsule diameter of about 10 micrometers to about 200 micrometers, an average shell thickness of about 170 nm to about 1000 nm; and
wherein the mean volumetric core-shell ratio is from about 80:20 to about 98:2;
wherein the oil-based core is a liquid at room temperature;
wherein said population has a shell permeability from about 0.01% to about 40%.