Patent ID: 11920116
Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
Field: Biotechnology (Chemistry)
Classification: CPC C | IPC C

Claim 0:
1. A microdevice for culturing human cervical cells, comprising:
an upper microchannel comprising live cervical epithelial cells;
a lower microchannel comprising:
a first parallel lane and a second parallel lane comprising stromal media, each of the first parallel lane and the second parallel lane being and wherein the first and the second parallel lanes are lined with live vascular endothelial cells,
a third parallel lane disposed between the first parallel lane and the second parallel lane and comprising a hydrogel comprising uterine fibroblasts and live smooth muscle cells embedded therein in hydrogel, wherein the first parallel, second parallel, and third parallel lanes of the lower microchannel are separated by
protrusion structures disposed between the first parallel lane and the third parallel lane and between the second parallel lane and the third parallel lane, a top surface of each of the protrusion structures being offset from a top surface of the lower microchannel wherein the third parallel lane is positioned in the lower microchannel in between the first and the second parallel lanes; and
a porous membrane positioned between the upper microchannel and the lower microchannel.