Patent ID: 11945842
Assignee: INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY (ICGEB)
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A  Y | IPC A  C

Claim 4:
5. A method of producing a bio-nanoparticle comprising an EDIII-T polypeptide comprising an EDIII domain of each of Dengue virus serotypes DENY-1, DENV-2, DENV-3, and DENV-4, wherein the C-terminal end of EDIII-T is fused to the N-terminal end of an HBsAg polypeptide, comprising culturing a host cell transformed or transfected with a nucleic acid sequence encoding the EDIII-T polypeptide fused to the HBsAg polypeptide under appropriate conditions and recovering the expressed bio-nanoparticle.