Patent ID: 11964050
Assignee: PHARMOSA BIOPHARM INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 10:
11. The pharmaceutical composition of claim 1, wherein the liposomes comprise:
(a) a lipid bilayer formed of a first phospholipid, a second phospholipid, and cholesterol, wherein the first phospholipid is hydrogenated soy phosphatidylcholine (HSPC), and the second phospholipid is distearyloylphosphatidylglycerol (DSPG); and
(b) an internal aqueous medium inside the lipid bilayer, the internal aqueous medium comprising a bicarbonate salt with a concentration about 50 mM to about 800 mM and a weak acid drug, said weak acid drug is Piroxicam or Meloxicam,, wherein the liposomes are suspended in an external medium, the pH of the external medium is above the pKa of the weak acid drug and less than about 7,, wherein the external medium is substantially free of bicarbonate salt such that there is from less than 2% to 0% bicarbonate salt and the encapsulation efficiency of the weak acid drug is at least 80%,, wherein the molar ratio of the weak acid drug to the bicarbonate salt is from about 0.1:1 to about 0.4:1.