Patent ID: 11938138
Assignee: WASHINGTON UNIVERSITY
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 0:
1. A method of sensitizing cancer cells to a chemotherapeutic agent or treating a subject having cancer cells, the method comprising:
(i) administering an effective amount of a BET inhibiting agent to a subject or cancer cells, wherein the cancer cells comprise stem-like or CD24high cells regulated by BRD4, wherein the effective amount of the BET inhibiting agent converts the cancer cells into a more chemotherapeutically-sensitive state and reduces an amount of stem-like or CD24high cells, and wherein the BET inhibiting agent is selected from the group consisting of ABBV-075, BAY1238097, BI 894999, BMS-986158, CPI-0610, CPI203, FT-1101, GS-5829, GSK525762, GSK2820151, I-BET, I-BET762, I-BET151, INCB054329, JQ1, OTX015, MK-8628, MS417, PFI-1, PLX51107, RO6870810, RVX2135, TEN-010, and ZEN003694; and
(ii) administering a chemotherapeutic agent to the cancer cells.