Patent ID: 11952363
Assignee: HOFFMANN-LA ROCHE, INC.
Field: Organic fine chemistry (Chemistry)
Classification: CPC C  A | IPC C

Claim 0:
1. A compound of formula (I),, wherein:
R1 is, , wherein R5 is cyano, C1-6alkoxy, C1-6alkyl or halogen;
R2 is C1-6alkyl;
R3 is R3a or —COR3b; wherein:
R3a is phenyl substituted by piperazinyl and (hydroxyC1-6 alkyl)piperazinyl, pyridinyl substituted by piperazinyl, C1-6alkylpiperazinyl, 9-oxa-3,7-diaza-bicyclo[3.3.1]nonanyl, (halopyrrolidinyl)amino, (pyrrolidinylcarbonyl)piperazinyl or (((C1-6alkyl)2amino)C1-6alkylcarbonyl)piperazinyl, or pyrimidinyl substituted by piperazinyl or (((C1-6alkyl)2amino)C1-6alkylcarbonyl)piperazinyl;
R3b is 7,8-dihydro-5H-1,6-naphthyridinyl substituted by piperazinyl, 3,4-dihydro-1H-isoquinolinyl substituted by piperazinyl, isoindolinyl substituted by piperazinyl, phenylamino substituted by piperazinyl, 1,2,3,4-tetrahydroisoquinolinyl, or C1-6 alkylpiperidinylpiperidinyl;

R4 is C1-6alkyl or H;
or a pharmaceutically acceptable salt, enantiomer or diastereomer thereof.