Patent ID: 11952411
Assignee: JANSSEN BIOTECH, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. An engineered TNF-like factor 1A (TL1A) ligand, wherein the engineered TL1A ligand comprises
a. at least one amino acid alteration of the amino acid sequence of SEQ ID NO:94 selected from the group consisting of K111, Q167, and E190 or;
b. at least one amino acid alteration of the amino acid sequence of SEQ ID NO:94 selected from the group consisting of K111A, K111S, K111E, L123G, L123S, L123E, L123K, Q167A, S187A, S187L, S187K, S187D, E190G, E190F, N207A, N207F, N207S, N207K and N207E,
and wherein the engineered TL1A ligand comprises a trimeric complex comprising:
a. three TL1A monomers, wherein the three TL1A monomers form a non-covalent TL1A trimer; or
b. three TL1A monomers, wherein the three TL1A monomers are covalently linked to form a single-chain TL1A (scTL1A) trimer.