Patent ID: 11926815
Assignee: S2 GENOMICS, INC.
Field: Measurement (Instruments)
Classification: CPC C  B  G | IPC C  G

Claim 30:
31. A cartridge comprising:
(i) a preprocessing chamber comprising:
(1) an opening and, positioned in the opening, a tissue disruptor configured for mechanical disruption of tissue, wherein the tissue disruptor comprises a plunger comprising a shaft and a head wherein the plunger is configured to rotate and be raised or lowered within the preprocessing chamber, and comprising a coupler to engage an actuator and a head for disrupting tissue,
wherein the head (1) has a circumference which when the head moves within the preprocessing chamber, provides a gap between the head and a wall of the preprocessing chamber between about 25 microns and 400 microns, and (II) comprises grinding teeth; and
(2) a preprocessing chamber port; and

(ii) a processing chamber comprising a processing chamber port communicating with the preprocessing chamber port through a fluid line, and
(iii) a cartridge port that communicates with the processing chamber, wherein a vacuum applied to the cartridge port pulls material from the preprocessing chamber into the processing chamber.