Patent ID: 11929144
Assignee: GENOME RESEARCH LIMITED
Field: Computer technology (Electrical engineering)
Classification: CPC G | IPC G

Claim 10:
11. The method of claim 10, further comprising:
determining that the rearrangement signature characterized by the presence of non-clustered tandem duplications less than 10kb in length is present in the DNA sample by determining if the number or proportion of rearrangements in the rearrangement catalogue which are determined to be associated with the rearrangement signature characterized by the presence of non-clustered tandem duplications less than 10kb in length exceeds a predetermined threshold; and
selecting the patient for treatment with a particular cancer therapy for patients whose cancer exhibit homologous recombination deficiency (HRD) when it is determined that the rearrangement signature characterized by the presence of non-clustered tandem duplications less than 10kb in length is present in the DNA sample.