Patent ID: 11952381
Assignee: CYTOKINETICS, INC.
Field: Organic fine chemistry (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A method of preparing a compound of formula (1b-10), or a salt thereof, comprising:
(i) reacting a compound of formula (1b-1), or a salt thereof, with a compound of formula (1b-2), or a salt thereof, to form a compound of formula (1b-3), or a salt thereof; and

(ii) converting the compound of formula (1b-3) or salt thereof to the compound of formula (1b-10) or salt thereof;
wherein:
R1 is selected from the group consisting of substituted or unsubstituted phenyl and substituted or unsubstituted pyridyl;
R2a is selected from the group consisting of substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted alkoxycarbonyl, substituted or unsubstituted aminoacyl, substituted or unsubstituted aminothionyl, substituted or unsubstituted acyl, substituted or unsubstituted aminosulfonyl, substituted or unsubstituted aminocarbonylamino, substituted or unsubstituted alkyl, substituted or unsubstituted pyridin-one-yl, substituted or unsubstituted pyridazin-one-yl, substituted or unsubstituted 9-membered bicyclic heterocyclyl, and hydroxyl;
R3 is selected from the group consisting of unsubstituted C2-C6 alkyl, alkyl substituted with alkoxy, cyano, or halo, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted cycloalkynyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, and substituted or unsubstituted heteroaryl;
R4 is H or unsubstituted alkyl;
R5 is H or substituted or unsubstituted alkyl;
n is 1 or 2; and
Alk1 is unsubstituted C1-C6 alkyl.