Patent ID: 11932854
Assignee: SIRNA THERAPEUTICS, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 1:
2. The composition according to claim 1, wherein:
(a) five or more pyrimidine nucleotides in NX4 positions are 2′-O-methyl nucleotides;
(b) five or more purine nucleotides in NX4 positions are 2′-deoxy-2′-fluoro nucleotides;
(c) five or more pyrimidine nucleotides in NX3positions are 2′-O-methyl nucleotides;
(d) five or more purine nucleotides in NX3 positions are 2′-deoxy-2′-fluoro nucleotides; and
(e) [N] position nucleotide(s) are any combination of ribonucleotides, deoxyribonucleotides, 2′-O-alkyl nucleotides, or 2′-halo nucleotides.