Patent ID: 11904054
Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  B | IPC A  B

Claim 1:
2. A composition comprising a simvastatin (Sim) and L-carnitine (L-Car) or Sim and D-mannitol (Man) particle, wherein said particle is a dry powder, wherein said Sim and L-Car particle has a MMAD of 19.55±2.52 μm, a FPF of 6.57±1.04%, and an ED of 93.65±5.53% and said Sim and Man particle has MMAD of 6.31±0.19, 9.86±1.13, 15.46±3.17, 7.29±1.04, or 13.28±0.84 μm, a FPF of 26.07±4.245, 9.15±1.55, 6.56±0.86, 17.57±3.36, or 10.40±3.16%, and an emitted dose ED of 100, 76.77±3.36, 70.93±10.09, or 89.84±5.52%, and wherein said particle is made by a method, comprising:
a) preparing a first solution comprising said Sim in methanol and a second solution comprising L-Car or Man in methanol;
b) mixing said first and second solutions to generate a mixture; and
c) spraying said mixture using a spray drying apparatus;
and wherein said composition is suitable for delivery by inhalation.