Patent ID: 11912709
Assignee: UNIVERSITY OF MASSACHUSETTS
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A temozolomide compound of structure (I), , wherein
X is —O— or —NRa—, wherein Ra is hydrogen or a C1-6 alkyl group;
L1 is a divalent C1-12 alkylene group, di(C2-12 alkylene) disulfide group, C2-12 alkylene ester group, C6-20 arylene group, C1-20 alkylene oxide group, or C1-12 alkylene sulfide group;
n is 0 or 1; and
R1 is a pentafluorophenyl group, a pyridyl disulfide group, a zwitterionic group having the structure A-B—C— or A-B—C-L2-, a glutathione group, or a thiamine group;
provided that when R1 is a pentafluorophenyl group, X is —O— and n is 0; and
wherein in the zwitterionic group structure A-B—C— or A-B—C-L2,
A is a center of permanent positive charge or a center of permanent negative charge;
B is a divalent group comprising a C1-12 alkylene group, a C6-30 arylene or heteroarylene group, or an alkylene oxide group; and
C is a center of permanent positive charge comprising a divalent ammonium group or a center of permanent negative charge comprising a divalent phosphate group,
provided that the zwitterionic group has an overall net charge of zero;
L2 is a divalent C1-6 alkylene group is covalently bound to L1 through a thioether bond or a disulfide bond; and
wherein the zwitterionic group is a phosphorylcholine zwitterionic group,
a sulfobetaine zwitterionic group, or a carboxybetaine zwitterionic group.