Patent ID: 11944685
Assignee: TIANJIN HAIRUNJAHE INNOVATIVE PHARMACEUTICAL RESEARCH LIMITED LIABILITY COMPANY
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A

Claim 9:
10. The pharmaceutical preparation of claim 9, wherein the polyaminopolycarboxylic acid modified Abiraterone derivative is prepared by a method comprising the following steps: dissolving the Abiraterone and the polyaminopolycarboxylic acid monoanhydride with molar equivalent being 1.1-3 times that of Abiraterone in N,N-dimethylformamide or N-methyl pyrrolidone or dimethyl sulfoxide, reacting at a temperature of −10-40° C. for 5 to 48 hours under a condition of the alkaline catalyst, after reacting completely, performing suction filtration to remove an insoluble substance, adding glacial ether to a filtrate, standing at a temperature of −40° C. for more than 2 hours until a precipitate is completely separated out, collecting the precipitate via centrifugation, dissolving the precipitate in a mixed solution of water and acetonitrile, extracting with ether, collecting an aqueous phase, freeze-drying the aqueous phase, and obtaining the polyaminopolycarboxylic acid modified Abiraterone derivative.