Patent ID: 11903972
Assignee: SANBIO, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 6:
7. A method for suppressing the function of a TH2 helper T cell in a subject, the method comprising:
administering to the subject an effective amount of cells, wherein the cells are obtained by a method comprising:
(a) providing a culture of mesenchymal stem cells;
(b) contacting the cell culture of step (a) with a polynucleotide comprising sequences encoding a Notch intracellular domain (NICD) wherein said polynucleotide does not encode a full-length Notch protein;
(c) selecting cells that comprise the polynucleotide of step (b); and
(d) further culturing the selected cells of step (c) in the absence of selection for the polynucleotide;

wherein the function is selected from one or more of:
(i) activation of antibody production by B-cells,
(ii) secretion of interleukin 4 (IL-4), and
(iii) secretion of interleukin 10 (IL-10).