Patent ID: 11884668
Assignee: KING FAISAL UNIVERSITY
Field: Organic fine chemistry (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A compound having the formula I:, or a pharmaceutically acceptable salt or stereoisomer thereof,
wherein:
R1 is H, C(O)OH, C(O)OR4, or OH;
R2 is H, C(O)OH, C(O)OR4, or OH;
R3 is C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 cyanoalkyl, (CH2)2-3NR7R8, (CH2)1-2aryl, (CH2)1-2heteroaryl, C(O)—(CH2)2-3NR7R8, C(O)aryl, C(O)heteroaryl, NH(CH2)2-3NR7R8, NH(CH2)0-1aryl, NH(CH2)0-1heteroaryl, NHC(O)—(CH2)2-3NR7R8, NHC(O)aryl, NHC(O)heteroaryl, NHS(O)2—(CH2)2-3NR7R8, NHS(O)2aryl, NHS(O)2heteroaryl, S(O)2—(CH2)2-3NR7R8, S(O)2aryl, S(O)2heteroaryl, C3-C6 cycloalkyl, C3-C6 halocycloalkyl, C3-C6 cyanocycloalkyl, aryl, or 5- or 6-membered heteroaryl;
wherein the aryl of (CH2)1-2aryl or the heteroaryl of (CH2)1-2heteroaryl is optionally substituted with one, two, or three substituents independently selected from the group consisting of halogen, CN, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 cyanoalkyl, C(O)R5, C(O)NR5R6, C(O)OR5, NR5R6, NHC(O)R5, NHC(O)NHR5, NHC(O)OR5, NHS(O)2R5, NHS(O)2NHR5, OR5, S(O)2NR5R6, C3-C6 cycloalkyl, C3-C6 halocycloalkyl, and C3-C6 cyanocycloalkyl;
wherein the C(O)aryl, C(O)heteroaryl, aryl of NH(CH2)0-1aryl, heteroaryl of NH(CH2)0-1heteroaryl, aryl of NHC(O)aryl, heteroaryl of NHC(O)heteroaryl, aryl of NHS(O)2aryl, heteroaryl of NHS(O)2heteroaryl, S(O)2aryl, or S(O)2heteroaryl is optionally substituted with one, two, or three substituents independently selected from the group consisting of halogen, CN, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 cyanoalkyl, C(O)R5, C(O)NRSR6, C(O)OR5, NRSR6, NHC(O)R5, NHC(O)NHR5, NHC(O)OR5, NHS(O)2R5, NHS(O)2NHR5, OR5, S(O)2NR5R6, C3-C6 cycloalkyl, C3-C6 halocycloalkyl, and C3-C6 cyanocycloalkyl; and
wherein the aryl or 5- or 6-membered heteroaryl is optionally substituted with one, two, or three substituents independently selected from the group consisting of halogen, CN, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 cyanoalkyl, C(O)R5, C(O)NRSR6, C(O)OR5, NRSR6, NHC(O)R5, NHC(O)NHR5, NHC(O)OR5, NHS(O)2R5, NHS(O)2NHR5, OR5, S(O)2NR5R6, C3-C6 cycloalkyl, C3-C6 halocycloalkyl, and C3-C6 cyanocycloalkyl;

each R4 is independently C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 cyanoalkyl, C3-C6 cycloalkyl, C3-C6 halocycloalkyl, or C3-C6 cyanocycloalkyl;
each R5 is independently H, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 cyanoalkyl, C3-C6 cycloalkyl, C3-C6 halocycloalkyl, or C3-C6 cyanocycloalkyl;
each R6 is independently H, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 cyanoalkyl, C3-C6 cycloalkyl, C3-C6 halocycloalkyl, or C3-C6 cyanocycloalkyl; or
any R5 and R6, taken together with the nitrogen atom to which they are attached, independently forms a nitrogen-containing heterocyclyl, wherein each nitrogen-containing heterocyclyl is optionally and independently substituted with one, two, or three substituents independently selected from the group consisting of halogen, C1-C6 alkyl, C1-C6 trihaloalkyl, OH, and OC1-C6 alkyl;
each R7 is independently H, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 cyanoalkyl, C3-C6 cycloalkyl, C3-C6 halocycloalkyl, or C3-C6 cyanocycloalkyl; and
each R8 is independently H, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 cyanoalkyl, C3-C6 cycloalkyl, C3-C6 halocycloalkyl, or C3-C6 cyanocycloalkyl; or
any R7 and R8, taken together with the nitrogen atom to which they are attached, independently forms a nitrogen-containing heterocyclyl, wherein each nitrogen-containing heterocyclyl is optionally and independently substituted with one, two, or three substituents independently selected from the group consisting of halogen, C1-C6 alkyl, C1-C6 trihaloalkyl, OH, and OC1-C6 alkyl.