Patent ID: 11952422
Assignee: CHUGAI SEIYAKU KABUSHIKI KAISHA
Field: Biotechnology (Chemistry)
Classification: CPC C | IPC C

Claim 5:
6. A tri-specific IgG antibody comprising:
a dual-binding Fab comprising a first variable region that binds to human CD3 epsilon and human CD137, but does not bind to human CD3 epsilon and human CD137 at the same time;
a second Fab comprising a second variable region that binds to a third antigen different from human CD3 epsilon and human CD137, wherein the third antigen is a cancer antigen; and
an Fc region,, wherein:
the first variable region comprises a VH and a VL;
the amino acid sequence of the VH has at least 95% sequence identity to the amino acid sequence of SEQ ID NO: 41, 30, 46, or 40; and
the amino acid sequence of the VL has at least 95% sequence identity to the amino acid sequence of SEQ ID NO: 51, 52, 53, 54, 55, 56, or 57.