Patent ID: 11969426
Assignee: GENENTECH, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A | IPC A

Claim 0:
1. A process for the manufacture of granules comprising an Akt inhibitor suitable for a pharmaceutical composition comprising the Akt inhibitor, a filler, a binder, and a moisture adsorbent, the process comprising the following steps:
(b) preparing a pre-blend by mixing the filler and the moisture adsorbent with the AKT inhibitor followed by introduction of the pre-blend into a fluid-bed granulator;
(c) preparing a granulation solution by dissolving the binder in a solvent followed by stirring until formation of a clear solution; and
(d) spraying the granulation solution onto the pre-blend in the fluid-bed granulator to obtain wet granules.