Patent ID: 11857289
Assignee: WASHINGTON UNIVERSITY
Field: Medical technology (Instruments)
Classification: CPC A  G | IPC A  G

Claim 15:
16. A non-transitory computer readable medium that includes computer-executable instructions for generating at least one optimized functional image of a lesion region of a breast, wherein when executed by at least one processor of a computing device, the computer-executable instructions cause the at least one processor to:
receive a plurality of measurements from a diffuse optical tomography (DOT) device, the plurality of measurements comprising lesion functional data from the lesion region of the breast and reference functional data from a healthy tissue region of a contralateral breast;
transform the lesion functional data and the reference functional data to produce perturbation data, the perturbation data comprising a normalized difference between the lesion functional data and the reference functional data;
generate a preliminary estimate of at least one functional image by applying a truncated pseudoinverse matrix of a weight matrix to the perturbation data, the weight matrix comprising a plurality of elements representing system measurement sensitivity of the breast and distribution of diffused optical waves in a homogenous medium;
generate the at least one optimized functional image by iteratively optimizing successive estimates of the at least one functional image regularized by the preliminary estimate of the at least one functional image weighted by a regularization parameter, wherein a value of the optimized at least one functional image at each voxel in the lesion region is indicative of a hemoglobin concentration at that voxel; and
display the at least one optimized functional image on a display device.