Patent ID: 11939379
Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C  G | IPC A  C

Claim 0:
1. A system comprising:
(a) a first chemically-induced dimer (CID) component comprising (i) a first binding moiety that is a protein capable of interacting with a small molecule to form a complex; and (ii) a first adapter moiety linked to the first binding moiety; and
(b) a second CID component comprising (i) a second binding moiety that is a protein that binds to the complex between the small molecule and the first binding moiety at a site of the complex comprising at least a portion of the small molecule and a portion of the first binding moiety; and (ii) a second adapter moiety linked to the second binding moiety;
wherein the binding of the second binding moiety to the complex between the small molecule and the first binding moiety creates a dimer between the second CID component and the first CID component,
wherein the first adapter moiety comprises a T cell antigen-binding moiety and the second adapter moiety comprises a target cell antigen-binding moiety; or the second adapter moiety comprises a T cell antigen-binding moiety and the first adapter moiety comprises a target cell antigen-binding moiety,
wherein the target cell antigen-binding moiety is an extracellular antigen-binding moiety,
wherein the first CID component comprises an ABT-199 binding domain comprising the amino acid sequence of SEQ ID NO:315; and
wherein the second CID component comprises an antibody moiety comprising three heavy chain complementarity determining regions (CDRs) and three light chain CDRs of an antibody clone selected from antibody clone FAB-AZ11, FAB-AZ12, FAB-AZ13, FAB-AZ14, FAB-AZ15, FAB-AZ16, FAB-AZ17, FAB-AZ18, FAB-AZ19, FAB-AZ20, FAB-AZ21, FAB-AZ22, FAB-AZ23, FAB-AZ24, FAB-AZ25, FAB-AZ26, FAB-AZ27, FAB-AZ28, FAB-AZ29, FAB-AZ30, FAB-AZ31, FAB-AZ32, FAB-AZ33, FAB-AZ34, FAB-AZ35, FAB-AZ36, FAB-AZ37, FAB-AZ38, FAB-AZ39, FAB-AZ40, FAB-AZ41, FAB-AZ42, and FAB-AZ43.