Patent ID: 11896606
Assignee: HIGHLIGHT THERAPEUTICS, S.L.
Field: Pharmaceuticals (Chemistry)
Classification: CPC A  C | IPC A  C

Claim 0:
1. An aqueous composition comprising one or more particles, wherein:
(a) each particle comprises a complex of at least one double-stranded polyribonucleotide, or a salt or solvate thereof, and at least one linear polyalkyleneimine, or a salt and/or solvate thereof, wherein
(i) the double-stranded polyribonucleotide is polyinosinic-polycytidylic acid [poly(I:C)], and
(ii) the weight average molecular weight of the linear polyalkyleneimine is between 17 and 23 kDa and has a molecular weight polydispersity index of below 1.5;

(b) at least 90% of the particles have a mono-modal diameter distribution of below 300 nm;
(c) the one or more particles each have a z-average diameter of less than or equal to 150 nm measured according to ISO 22412:2008; and
(d) the aqueous composition has a zeta potential equal to or greater than 30 mV measured according to ISO 13099-2:2012.