Patent ID: 11905529
Assignee: IMMATICS US, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. A method of producing T cells comprising
(a) activating T cells obtained from at least one individual,
(b) expanding a first portion of the activated T cells over a plurality of different periods of time selected from about 1 day to about 15 days after the activating,
(c) culturing the expanded first portion of the activated T cells in (b) in the presence of at least one cytokine and in the absence of antigen presenting cells over a period of at least 21 days,
(d) measuring a cytokine response in the cultured T cells in (c) in the absence of continual cytokine stimulation,
(e) comparing the cytokine response in (d) to identify a period of time from the plurality of different periods of time in (b) that yields a maximum cytokine response in (d), and
(f) expanding a second portion of the activated T cells in (a) for the period of time identified in (e) that yields the maximum cytokine response in (d),
wherein the cytokine response comprises an increased population of naïve  T cells (TN) and stem memory T cells (Tscm).