Patent ID: 11970545
Assignee: MCMASTER UNIVERSITY
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 0:
1. An engineered γδ T cell comprising an expression vector comprising a nucleic acid encoding a T Cell-Antigen Coupler (TAC) polypeptide, the TAC polypeptide comprising:
(a) an antigen-binding antibody fragment or DARPin that selectively binds a target antigen;
(b) a humanized UCHT1 (huUCHT1) polypeptide comprising the amino acid sequence of SEQ ID NO: 28; and
(c) a T cell co-receptor domain polypeptide comprising a CD4 cytosolic domain and a CD4 transmembrane domain, wherein the TAC polypeptide is expressed by the engineered γδ T cell.