Patent ID: 11884648
Assignee: CELGENE QUANTICEL RESEARCH, INC.
Field: Organic fine chemistry (Chemistry)
Classification: CPC C  A | IPC C

Claim 0:
1. A method of inhibiting a histone demethylase enzyme selected from a group comprising FBXL10, JARID1B, JMJD2C and JMJD3 comprising contacting a histone demethylase enzyme with an effective amount of a compound of Formula II, wherein a compound of Formula II is optionally a pharmaceutically acceptable salt thereof, and wherein
R2 is halogen or —CF3;
R3 is hydrogen, halogen, —OH, —OR6, —N(R6)2, or alkyl, carbocyclyl, aryl optionally substituted with halogen, carbocyclylalkyl, or aralkyl optionally substituted with halogen or alkyl;
R4 is hydrogen, halogen, —OH, —OR6, —N(R6)2, or alkyl, carbocyclyl, aryl, carbocyclylalkyl, or aralkyl; wherein

each R6 is independently hydrogen, or optionally substituted alkyl, carbocyclyl, aryl, carbocyclylalkyl, or aralkyl; and
R5 is hydrogen, methyl, ethyl, isopropyl, t-butyl, —CHF2, —CH2F, —CF3, —CH2OH, —CHCH3OH, or —C(CH3)2OH.