Patent ID: 11866428
Assignee: ASTEX THERAPEUTICS LIMITED
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 18:
19. A process for preparing a protected form of formula (I) as defined in claim 1 which comprises:
(I) (a) (i) reacting a compound of formula (II):, wherein P1 represents a suitable protecting group, with a compound of formula (III):, followed by a deprotection reaction suitable to remove the P1 protecting group; or
(ii) reacting a compound of formula (III) as defined above with a compound of formula (IV):, wherein L1 and L2 independently represent suitable leaving groups, then subsequent reaction with a compound of formula (V):, wherein P1 represents hydrogen or a suitable protecting group, followed by a deprotection reaction suitable to remove the P1 protecting group; and/or
(b) interconversion of a compound of formula (I) or protected derivative thereof to a further compound of formula (I) or protected derivative thereof; and
(c) optional formation of a pharmaceutically acceptable salt of a protected derivative of formula (I); or
(II) the interconversion of a protected derivative of formula (I) to a further protected derivative of formula (I) comprising the following reaction:, wherein P1 represents a suitable protecting group, and Het represents a 3-12 membered heterocyclyl group which may be optionally substituted by one or more Rb groups.