Patent ID: 11859002
Assignee: THE GENERAL HOSPITAL CORPORATION
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A  Y | IPC A  C

Claim 0:
1. A humanized or chimeric antibody or antigen-binding fragment thereof comprising a non-native constant region and each of the following complementarity determining regions (CDRs)
(a) a CDR heavy chain 1 (CDR-H1) having the amino acid sequence GYTFTDYX (SEQ ID NO: 257);
(b) a CDR-H2 having the amino acid sequence VDPEYGST (SEQ ID NO: 258);
(c) a CDR-H3 having the amino acid sequence ARDDGSYSPFDYWG (SEQ ID NO: 259);
(d) a CDR-L1 having the amino acid sequence QNINKY (SEQ ID NO: 260);
(d) a CDR-L2 having the amino acid sequence TYS or YTS; and
(e) a CDR-L3 having the amino acid sequence CLQYVNLXT (SEQ ID NO: 261);
wherein each X is independently leucine or isoleucine; and wherein the antibody or antigen-binding fragment thereof specifically binds human tumor necrosis factor receptor 2 (TNFR2) and inhibits TNFR2 signaling.