Patent ID: 11958898
Assignee: NEW YORK UNIVERSITY
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A  G | IPC A  C  G

Claim 0:
1. An antibody-based molecule that is capable of immunospecifically binding to the Truncated Asp421 Epitope of Tau, wherein said epitope is present on a peptide having the sequence of Tau 407-421 (SEQ ID NO:7): HLSNVSSTGSIDMVD, wherein:
(A) said aspartate residue of SEQ ID NO:7 is the C-terminal Tau residue of said polypeptide;
(B) relative to said immunospecific binding, said antibody-based molecule exhibits diminished binding to a polypeptide that contains additional Tau sequence residues C-terminal to said aspartate residue of SEQ ID NO:7; and
(C) said antibody-based molecule comprises:
(i) a Variable Light Chain CDR1, CDR2, CDR3 having the amino acid sequence of SEQ ID NOs:17, 18 and 19, respectively; and
(ii) a Variable Heavy Chain CDR1, CDR2, CDR3 having the amino acid sequence of SEQ ID NOs:21, 22 and 23, respectively.