Patent ID: 11946867
Assignee: MEMORIAL SLOAN KETTERING CANCER CENTER
Field: Measurement (Instruments)
Classification: CPC G | IPC G

Claim 0:
1. An interferometric modulation imaging apparatus for multi-color interferometric imaging of at least one fluorescent sample, comprising:
a first optical objective and a second optical objective, the first optical objective configured to (i) focus a first excitation beam toward the at least one fluorescent sample located in a volume between the first optical objective and the second optical objective, and (ii) collect a first portion of light provided from the at least one fluorescent sample, wherein the second optical objective located within a first distance from the first objective so as to (i) focus a second excitation beam toward the at least one fluorescent sample, and (ii) collecting a second portion of light provided from the at least one fluorescent sample;
a dichroic mirror configured to direct an illumination beam toward one or more beam splitters that (i) splits the illumination beam into the first excitation beam and the second excitation beam, and (ii) combines the first portion of the provided light with the second portion of the provide light to form an interference signal;
one or more phase modulating devices arranged to:
direct the first excitation beam from the one or more beam splitters to the first optical objective, and
direct the first portion of the provided light collected at the first optical objective to the one or more beam splitters;

a set of mirrors arranged so as to:
direct the second excitation beam from the one or more beam splitters to the second optical objective and
direct the second portion of the provided light collected at the second optical objective to the one or more beam splitters; and

one or more detectors configured to detect the interference signal.