Patent ID: 11866428
Assignee: ASTEX THERAPEUTICS LIMITED
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 7:
8. The protected form of formula (I) as defined in claim 1, wherein:
(i) R9 is selected from halogen, —(CH2)s—CN, C1-8 alkyl, —Y—C3-12 carbocyclyl, —Z-(3-12 membered heterocyclyl), —S(O)q—(CRxRy)s—Rz or —(CH2)s—SO2NRxRy, wherein said carbocyclyl groups or heterocyclyl groups may be optionally substituted by one or more Rb groups such as ═O, halogen, C1-6 alkyl, —(CH2)s—CN or —(CRxRy)s—O—Rz; or
(ii) R9 is selected from chlorine, fluorine, bromine,—CN, methyl, ethyl, propyl, isobutyl, butyl, —(CH2)2-CH(CH3)2, —CH2-phenyl, —CF2-phenyl, —CH(CH3)-phenyl, —CH(OCH3)-phenyl, —C(=CH2)-phenyl, —O-phenyl, —SO2-phenyl, —C(═O)-phenyl, —CF2-cyclopropyl, —CF2-cyclobutyl, —CF2—CH2-cyclobutyl, -cyclopentyl, -cyclopentenyl, —CH2-cyclohexyl, cyclohexyl, cyclohexenyl,-pyrazolyl, -furanyl, -thienyl, -oxadiazolyl, -tetrazolyl, -benzofuranyl, —CH2-pyrrolidinyl,—SO2CH3, —SO2—CH2CH(CH3)2, —SO2—CH2-phenyl, —SO2N(CH3)2, wherein said phenyl, pyrazolyl, furanyl, thienyl, oxadiazolyl, tetrazolyl, benzofuranyl or pyrrolidinyl groups may be optionally substituted by one or more Rb groups such as ═O, fluorine, chlorine, methyl,—CN or methoxy; or
(iii) R9 is selected from —(CRxRy)1-2-cyclopropyl, —(CRxRy)-cyclobutyl,—(CRxRy)-phenyl, ethyl, propyl or butyl each of which may be optionally substituted by one or more halogen atoms (e.g. fluorine) and wherein Rx and Ry are independently selected from hydrogen and fluorine; or
(iv) R9 is —CH2-(4-fluorophenyl).