Patent ID: 11932702
Assignee: ABLYNX N.V.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 16:
17. A polypeptide that comprises at least one immunoglobulin single variable domain (ISVD) that specifically binds Glypican-3 (GPC3), wherein said ISVD comprises three complementarity determining regions (CDRs, CDR1 to CDR3, respectively, and wherein the at least one ISVD comprises:
a) a CDR1 consisting of the amino acid sequence of SEQ ID NO: 7;
a CDR2 consisting of the amino acid sequence of SEQ ID NO: 11; and
a CDR3 consisting of the amino acid sequence of SEQ ID NO: 15; or

b) a CDR1 consisting of the amino acid sequence of SEQ ID NO: 8;
a CDR2 consisting of the amino acid sequence of SEQ ID NO: 12; and
a CDR3 consisting of the amino acid sequence of SEQ ID NO: 16.