Patent ID: 11884719
Assignee: 23ANDME, INC.
Field: Pharmaceuticals (Chemistry)
Classification: CPC C  A | IPC A  C

Claim 6:
7. The antibody of claim 1, wherein the antibody binds to hu-IL-36α, hu-IL-36-β, and/or hu-IL-36-γ with a binding affinity of 1×10−8 M or less, 1×10−9 M or less, 1×10−10 M or less, or 1×10−11 M or less;
the antibody binds to hu-IL-36α and hu-IL-36-γ with a binding affinity of 1×10−8 M or less;
the antibody binds to hu-IL-36-β with a binding affinity of 1×10−8 M or less;, the antibody decreases an intracellular signal stimulated by IL-36α, IL-36β, and/or IL-36γ by at least 90%;
the antibody inhibits release of IL-8 from primary human keratinocytes (PHKs) stimulated by IL-36α, IL-36β, and/or IL-36γ; and/or
the antibody cross-reacts with an IL-36α, IL-36β, or IL-36γ of cynomolgus monkey having the amino acid sequence of SEQ ID NO: 5, 6, or 7.