"Originally published in Science Express on 17 May 2007 Science 8 June 2007 : Vol . 316. no . 5830 , pp . 1484 - 1488 DOI : 10.1126/science.1138341 Prev | Table of Contents | Next Reports RNA Maps Reveal New RNA Classes and a Possible Function for Pervasive Transcription Philipp Kapranov,1 Jill Cheng,1 Sujit Dike,1 David A. Nix,1 Radharani Duttagupta,1 Aarron T. Willingham,1 Peter F. Stadler,2 Jana Hertel,2 JÃ¶rg HackermÃ¼ller,3 Ivo L. Hofacker,4 Ian Bell,1 Evelyn Cheung,1 Jorg Drenkow,1 Erica Dumais,1 Sandeep Patel,1 Gregg Helt,1 Madhavan Ganesh,1 Srinka Ghosh,1 Antonio Piccolboni,1 Victor Sementchenko,1 Hari Tammana,1 Thomas R. Gingeras1 * Significant fractions of eukaryotic genomes give rise to RNA , much of which is unannotated and has reduced protein-coding potential . The genomic origins and the associations of human nuclear and cytosolic polyadenylated RNAs longer than 200 nucleotides ( nt ) and whole-cell RNAs less than 200 nt were investigated in this genome-wide study . Subcellular addresses for nucleotides present in detected RNAs were assigned , and their potential processing into short RNAs was investigated . Taken together , these observations suggest a novel role for some unannotated RNAs as primary transcripts for the production of short RNAs . Three potentially functional classes of RNAs have been identified , two of which are syntenically conserved and correlate with the expression state of protein-coding genes . These data support a highly interleaved organization of the human transcriptome ."
"And the introductory paragraph is interesting also ."
"Significant fractions of eukaryotic genomes give rise to RNA , much of which is unannotated and has reduced protein-coding potential . The genomic origins and the associations of human nuclear and cytosolic polyadenylated RNAs longer than 200 nucleotides ( nt ) and whole-cell RNAs less than 200 nt were investigated in this genome-wide study ."
"And the introductory paragraph is interesting also ."