#version: 0.2 - Trained by `huggingface/tokenizers` i n Ġ t Ġ a r e h e o n t i t e Ġt he Ġ o e n Ġ s Ġ c Ġ in Ġ p Ġ w Ġa n a l e s Ġo f o r e r e d ti on r o a n Ġ f Ġ d Ġan d i s Ġ m i t Ġ b a s i c in g a t Ġ re a r u s Ġ ( e c e l Ġt o Ġ e te d l e a tion en t Ġ h Ġt h i r a c l y o m Ġ n u l Ġ v o s i m i g e re o l i d u n it h te r Ġ l Ġw ith u r Ġp ro v e Ġf or Ġ g t r i l c e Ġc on Ġ 1 Ġa s Ġb e u c Ġ 2 Ġ [ a te i f o w re s el l a ted Ġ is a m Ġw ere Ġth at f ec Ġw as u m Ġa l T he o d o t Ġ C Ġe x u t Ġre s ) . Ġd e a in a b t s Ġ on it y Ġb y q u Ġv ir Ġs t v er o c Ġ S ti c i on s e he r a y ro m Ġc ell Ġ I o p o g u d t h a g Ġo r u re Ġc om a ti Ġa c Ġ P p l a d Ġ A Ġ r i b Ġs e Ġ us Ġf rom as e Ġ H Ġt r m ent Ġa t Ġ R Ġin fec ] . Ġ M Ġa re u p Ġ T i es v el Ġ im in e 0 0 p ec Ġg en Ġ 3 an t Ġd is an s u b o re N A a p Ġvir us Ġw h Ġin c i z u g Ġpro te es s o us p or Ġcell s s t Ġcom p Ġp re d uc Ġm e t her ic al Ġs h Ġc h Ġ en un d g e y s ) , i v en ce Ġa d Ġ E ig h I n Ġex p i ti Ġ N res s if ic Ġ D Ġn e Ġc o Ġan ti Ġp er Ġst ud ig n n t ic h an d Ġ 5 Ġprote in F ig Ġ B ent s Ġw e Ġinfec tion t ing i p Ġtr ans Ġ 4 Ġcon t ab le Ġ he Ġh a a re os t v ir y p Ġn ot Ġth is Ġ le Ġs tr Ġ G or m Ġin f i a i tion i al Ġwh ich Ġas s e m Ġc l or y f ere ation s er s Ġha ve ac t d ing Ġres p ti v ar y om e Ġin d m un Ġd if at h Ġ it i ed 0 1 p le l u Ġp ar en c t w Ġp o te n Ġe f Ġa p p h v ed Ġs ign Ġsh ow Ġ F al ly c h en s t o Ġin ter en ti il l on s as ed Ġ L Ġre c Ġs am Ġc an Ġus ing Ġ k s o Ġd i a k Ġp l an ce Ġs pec Ġ 0 ol og on g as es ate s v i Ġal l p ro Ġbe en Ġdif fere ag e Ġm od Ġo b ol l Ġvir al ug h Ġcon s c tion Ġal so Ġa b Ġw he Ġan al Ġ un ul d Ġg ro Ġstud y ac h f ic u e Ġe t Ġp ati m in Ġe v es t Ġd at ro l Ġs ub ul ar or s at ory Ġres ul Ġm ic Ġh as Ġre g Ġim mun Ġexp ress c r e p Ġse qu al l ti ve Ġthe se e en Ġdis e Ġa f Ġo ther ar i Ġp os ati ve Ġus ed l ud Ġ 6 tw een Ġbe tween vir us Ġa g Ġp r R S e ar Ġ U Ġh um Ġac tiv pl ic Ġp ath p t is s T h . , te m e ver tion s re d por t d ition Ġ2 01 os e ti m Ġef fec f orm Ġp res ay s uc h o und Ġdat a Ġo ut Ġpati ents al th Ġ1 0 Ġm ay Ġ id Ġt re Ġde te Ġn o en d e t Ġ V Fig ure i te o V o ur Ġh igh as t Ġth an Ġinc re ĠR NA iz ed Ġinc lud il ity b er ac c i k s er a us Ġs er Ġgro up 1 0 Ġd es igh t Ġ ro ar ge ul ation as s og en Ġ 7 Ġanal ys n e Ġp h Ġa m oc i Ġt im Ġm ore w o at ing r i Ġn um al s Ġle vel Ġ y y l ar d Ġb ut id e h ib re e Ġid enti Ġs c Ġc or Ġsign ific c t ot h en z Ġanti b Ġs y Ġvirus es Ġ W ac ter ent r Ġs ur vel y R NA Ġac c Ġv acc Ġ O t ain are d Ġcont rol g en g es t ure ur ing Ġthe ir Ġmod el duc ed Ġre l Ġinf lu Ġdise ase Ġt wo vel op C R Ġe p Ġ2 00 Ġc y Ġin v Ġexpress ion ed i Ġgen e enz a Ġs p in ding Ġhum an Ġsignific ant o ut m b C oV ys tem Ġre por Ġv ari yp e u tion Ġ qu Ġprotein s i le Ġm an Ġs uch Ġs im Ġs up on d Ġhe alth r an d e Ġin to Ġob ser ec t ow ever Ġ 9 i ve l o Ġsam pl Ġ und a il Ġe ach is t u te ain s Th is Ġdiffere nt Ġantib od Ġaf ter 1 1 Ġb oth Ġ K u es f er u res uc le in es he d p er Ġanalys is ec h Ġon e oll ow Ġresul ts duc tion Ġin hib e w Ġl ow Ġnum ber Ġstud ies Ġcon c ĠI F Ġs ystem m er W e un ction ro s ol d Ġde velop Ġ = iz ation Ġon ly il d Ġ 8 ow n or k Ġo ver c ess el y Ġund er Ġidenti f Ġpar tic Ġgen er Ġd uring iti ve he s Ġinflu enza t al Ġcomp le vi ous Ġtim e Ġ el Ġmic e Ġm in Ġf ollow Ġb i o uld Ġthe re Ġsequ enc Ġass oci Ġo ur Ġfor m on e m o Ġs ec ur ther Ġpro v Ġs ug Ġinfec ted Ġap pro Ġm ost Ġco uld il ar Ġsampl es l es Ġc ases Ġm on ec ted r ap is m Ġind ic ac k Ġf ound Ġf act o ugh Ġshow n ] , am m Ġh ad a ter Ġv al Ġit s ir atory ac e 1 2 f ore tr ib i x in ation Ġper form oc k c es in ical ĠC D Ġme th Ġw ell Ġ up A l on se Ġ Î a v ti al Ġpr im Ġre plic S A ro ugh Ġn on Ġde ter Ġf unction ion s m iss Ġobser ved at ment Ġd ec Ġdiffere n ul ated Ġpre vious fec ted cr ib ac tion Ġad dition ĠI n c c Ġrepor ted an ts ter n g r Ġstr uc ' s Ġ1 9 Ġresp iratory ir st ib le H owever ent ly as m olog ical Ġ es aus e Ġresp onse Ġexp er Ġh ig ain ing fic i Ġt arge u al ce pt Ġspec ific I V iti es Ġm ut Ġlevel s Ġag ain ti vely Ġus e Ġcl inical d er cr ip em ic Ġp op Ġn ucle u f Ġtre atment Ġmeth od i ted 2 0 un g c ted Ġim port Ġcomp ared Ġen d Ġactiv ity Ġth rough Ġme as F or Ġcon f ter s Ġh ost Ġre p v ere Ġk n Ġwhe re Ġa r ĠS A ub l Ġinclud ing Ġch an Ġdes crib Ġf r m on qu i Ġt es Ġwhe n at ure iv id Ġde m Ġan im Ġsim ilar Ġme mb o x Ġex am Ġc oll v en Ġagain st Ġco un if ied Ġs el ti t Ġac id ĠIF N miss ion Ġsequ ence 1 5 Ġgen es tic al a virus Ġshow ed Ġ J Ġpo ten Ġd r T o os is te nt Ġm ul Ġ - ment s Ġ â Ġf irst Ġpro b re n olog y Ġl oc iz e Ġth ree Ġres pec Ġwith in Ġimmun e os p i o re ak Ġ  Ġassoci ated ation al a f he n ĠD NA ver s p ar ol ec 1 3 Ġr is Ġinhib it ab ility Ġo cc ons tr Ġs ite om es Ġperform ed Ġis ol ag n en g a tic Ġpo ly v al ti l Ġpre d ro ph Ġs ome Ġpro cess Ġy ear Ġsug ges 1 4 Ġd ays Ġa ut ag es o ver in ed p os oc y e x Ġw ill Ġthe n Ġm a in d Ġinfection s osp it Ġresp ons Ġc ap b reak Ġin s Ġpres ent Ġhig her Ġ q Ġsequenc es tain ed Ġpos s us ion Ġl ik Ġidentif ied A s Ġb ec Ġthe y Ġdescrib ed The se Ġb inding Ġreplic ation Ġincre ased Ġp ubl at s y m S V Ġout break Ġc ul ep ti Ġm edi ar k Ġeffec t in al 1 6 Ġconc entr an ism s pec ĠC h re l Ġind ivid id ence am e Ġre qui Ġpos itive c l tr ac Ġ2 0 Ġdete cted Ġmul ti ti g Ġ + Ġse ver re ct Ġne w Ġexper im Ġth ose Ġep id Ġc le enc y te s ĠSA RS Ġ ly en ted th ough Ġimport ant Ġa v o un ĠI L Ġm olec Ġdem onstr Ġmic ro Ġris k Ġin te o ti Ġf urther Ġmemb ran Ġc al ar r i qu Ġ " Ġb acter Ġd om o f Ġ The o virus pt om n ess l amm 1 9 ĠM E Ġrespec tively or d Ġantibod y he l Ġo p Ġc ase ti ous Ġb ased Ġd el ur al Ġspec ies Ġocc ur Ġ5 0 o 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Ġanal y Ġs ingle T A C V ly c Ġle ad Ġfollow ing Ġpubl ic Ġres id Ġprov id Ġd id B S Ġp ur Ġt est ik e rap h P CR D V Ġ à or t p r ĠME RS Ġp ost o od ul t he m Ġa ge in a T able Ġav ail Ġan y vi ew ate ly o ve Ġsy m ain ed j or Ġyear s Ġf l p s d ed Ġmech anism Ġass ess Ġdec re ical ly Ġne u Ġf lu it ro ic k Ġch ild Ġm or Ġrespons es tr al Ġob tained Ġmembran e Ġma jor Ġ2 4 2 9 i od Ġim p Ġne g Ġpro duc Ġcom mon se qu ten s ep endent Ġse vere Ġfact ors i or us t n d Ġcl ass m edi it her Ġeffec ts in k Ġcon dition ce p Ġ1 00 iv en tr ic ne um Ġinform ation os ph f ul Ġincre ase ear ch Ġf e Ġ if B V Ġsym ptom Ġdis c Ġsever al ech n ĠH IV Ġsh ould Ġ j on al Ġb lood Ġcul ture i um Ġper iod Ġg re Ġs ens Ġpro duction ific ation Ġkn own Ġstr ain Ġsam ple spec ific or ding Ġlow er Ġdevelop ment Ġdis trib 5 0 Ġh yp mer g f ace on avirus b in I I r ic er n in fected Ġman y re qu ĠÎ ¼ Ġanim als Ġser um  ° Ġhospit al u ted Ġgro w m it ot her ĠI g y d Ġstruc t A n is hed Ġre le l d Ġinf lamm fici 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Ġhigh ly Ġchan ges Ġneg ative tr ies og raph Ġrecept or ven tion Ġm ark Ġamin o m ph Ġinclud ed I D Ġdom ain en e Ġf our E V ver se P s Ġsur face P A ul ations ak e Ġpartic ular A d eng th F urther Ġen h Ġm at ĠU SA ĠR T Ġdifferen ces f ter Ġcon trib on ia N V c i ver age Ġt echn c ell res p Ġst andard Ġp at l ike Ġre ve Ġs w M V Ġme an o id Ġc are b r Ġexpress ed Ġcur rent Ġre duced to k Ġcon tr rom e Ġres earch Ġbe ing Ġlab or Ġhe l ac tiv ore d c y Ġb el Al though Ġexperim ent n al ĠN S te red Ġexam ple t y d uce Ġch all Ġcor onavirus Ġcom b Ġcondition s re en G A Ġs ize Ġin tr Ġstr ateg Ġf ac hes is ul es Ġincub ated Ġa ir Ġmethod s Ġf ul Ġ1 8 R T y n Ġcoun tries R V v ant pec ted L A Ġ2 5 Ġph osph Ġcom mun D NA Ġrequi red Ġtranscrip tion Ġc at ab l Ġm ix ab ly Ġ19 9 Ġs l u ally o v tw ork Ġtre ated Ġdevelop ed Ġv ia ill ance Ġfollow ed Ġidentif y 2 8 e y ot ype Ġconsid ered Ġcy tok Ġinvol ved Ġrepres ent iz ing Ġconcentr ation Ġtem per F P at a Ġanim al ĠU n Ġreg ions Ġreve al a x Ġs o Ġanalyz ed ti b ĠCh ina Ġstr ong Ġ1 3 Ġacc ording a e Ġsymptom s Ġtiss ue Ġv is Ġm g c er Ġev idence Ġde ath a z A fter Ġv ery Ġpro mo Ġpartic ip Al l m ine Ġw ild Ġpneum onia al ity z ym Ġrec ogn et y m l Ġbacter ial ap p 0 5 Ġc r u als n ot Ġprim ary Ġsite s Ġconfirm ed iel d Ġam pl Ġfact or Ġhum ans Ġdiagn os Ġ ' m e Ġprov ide Ġm ouse vir on Ġdeter mine Ġin j Ġappro ach A b Ġv i vers ity 3 3 Ġpat tern Ġn ec min is A V n ing Ġsp read Ġeffec tive Ġcl us Ġdistrib ution uf fer Ġ u ar t Ġn ormal Ġval ue y c Ġinter action Ġab ove Ġor der Ġneu tral er g Ġpar t Ġgene tic op l L R ro und Ġindivid ual ĠS t Ġr ap Ġpar ame Ġvari ous Ġpr ior ati vely Ġin duced L I c ed Ġpre v Ġran ge Ġne twork ul ate Ġindic ated ocy tes Î ± C C Ġunder st Ġle ast w ays Ġ X Ġex trac feren ce Ġh our is ed te ro Ġindivid uals I K Ġ z Ġd on if e Ġpro f Ġd og f old Ġmolec ular ac y Ġs uc Ġv itro Ġthe m ir c in c tr ans w ard Ġh om Ġb r Ġsurve illance m a Ġev en Ġ µ e u O V g l Ġd own Ġp ol Ġd er Ġd il and emic Ġ entr Ġdete ct Ġ est Ġcont act Ġrap id I F M ore 3 5 an e Ġcomple te om p Ġly s Ġl ack as ing u tions Ġh ist tal ity Ġt i iv al Ġisol ated tr ation Ġfinding s Ġpath way Ġrec ent Ġh owever oun t se t c o t ype ti ally Ġvacc ines 3 4 P V in ated Ġpepti de Ġcor resp Ġth us Ġs tim Ġc ar Ġexperim ents v ity ter min C D ic s ial ly 3 8 ĠC A ol s op y Ġ1 1 g est C l Ġbl ock Ġsub j Ġor ig cep tib ti es Ġpro t er v Ġen viron Ġsignal ing Ġres ist Ġmor tality x t Ġcontr ast Ġre f t t el s id s Ġg r IK V Ġen zym enti al Ġtemper ature Ġc ause P S Ġg l s tit Ġre mo if er Ġp andemic Ġest abl Ġgrow th E M Ġcon duc Ġf usion O ur Ġad ded and s ir d i RNA Ġly mph Ġg iven Ġno vel There fore ĠIg G or ld o k Ġst atis in duced Ġsug gest 3 6 Ġr ates Ġass ays ti s Ġe m Ġtim es ĠT h ic ity iti vity fic ation Ġcons truc Ġv ol se mb ĠR SV ĠI I Ġ Y m ore ell ular Ġc entr op e Ġmeasure d Ġreveal ed Ġresid ues Ġentr y Ġel e Ġad minis a w Ġvacc ination Ġmedi um Î ² Ġr ati pl ied Ġ Q Ġ1 7 Ġs ol Ġlabor atory Ġab ility Th us Ġc irc h ip Ġsus ceptib bin ant Ġgener ated opl asm Ġâ ĪĴ oti de Ġfam ily Ġinter actions Ġbe t O n Ġmon th ĠHe alth ĠP BS Ġenc od 3 7 h old Ġo l ĠE R Ġsc reen Ġg lob c ence Ġaddition al os s fec t 8 0 Ġl ink W h ĠH A Ġc he Ġunderst and Ġf il Ġs ince Ġsub sequ f or iv o ib ility Ġb uffer hel ial Ġout c Ġt ypes n er Ġpos ition Ġre view Ġwhere as ute s Ġsel ected Ġaut h t osis Ġchall en Ġgener al Ġpro gr or g Ġre al Ġre action im ens Ġpartic les Ġinhib ition ir us Ġrel ative b or Ġvect or u k Ġl arg Ġconcentr ations Ġsugges ting 1 00 Ġal though Ġmac roph Ġcont in ur ation Ġacc ess i er / / Ġdog s Ġc ross Ġdifferen ce P E H V is tic ap s en se Ġcomp ound ĠA s op rote Ġpre val Ġorg an ĠO RF Ġv ivo Ġsecond ary Ġf oc and om em i Ġg u Ġenviron ment S T Ġph ys Ġab le Ġinclud e ul ating p i Ġconsis tent fici ency Ġcaus ed h a Ġsystem s til l Ġ4 0 g ress ĠT r Ġc arr : // Ġlim ited Ġcalc ulated Ġcomp on es is Ġsequenc ing 4 9 Ġad ap u it ib r Further more 3 2 Ġp hen is on Ġthere fore Ġrecom 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ently T R tw are ub le Ġ > ag en o tic Ġs um ĠA r Ġ201 3 Ġap plic ron ic ro w Ġin tro Ġcorresp onding Ġev ents ul ts Ġr ib an ces Ġal ign Ġacid s Ġl ig Ġder ived Ġbet ter Ġin n ro b ' t Ġcons erved Ġnum bers e th Ġres tric of tware Ġo x Ġgre ater Ġpro gress ol ar ab or Ġap op f in at us Ġpreval ence ĠÃ Ĺ Ġpre print ro up Ġph ase ern at us s Ġproduc ts 7 1 im ilar Ġindic ate an tit om al ) ; ut ure Ġcontrol s Ġ ur Ġsynt hesis Ġevalu ated Ġmeas ures Ġ ec Ġsy n Ġ ± T T Ġassoci ation Ġhyp ot Ġfunction s Ġpig s Ġprote ction Ġbi ological Ġpur ified Wh ile w h Ġn as Ġpres ented ĠP A at ors el ine Ġup on Ġpropor tion uf act Ġprogr am Ġre port LI SA Ġin tens Ġmut ant ĠN P Ġresist ance Ġstruct ural Ġin duction Ġsh ort Ġst ate Ġrequi re Ġd ynam 4 7 ĠM A Ġtherap eu in ary Ġpro l Ġ201 5 Ġindic ating p ri Ġb ack re am Ġâ Ģ Ġm ater se ud Ġman ufact Ġpe ople O ne up plementary Ġincub ation Ġt e N P Ġbe ha Ġtherap y Ġ201 2 om a Ġm al Ġg o ĠB i Ġf ield ĠA f in ts j ug H C Ġmonth s ur n Ġgen omic Ġad d 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SP V ector b ach Ġan orexia or ial Ġb are Ġto w Ġl ived ĠM K Ġne i ĠL ister Ġimmun izations Ġpr ice Ġtim eliness crib ing Ġmethod ological Ġdr ives ins ically PA C ĠPP RV Ġtraject ory M il S yn S ignific k o Ġs ure Ġv ice os ylated ot om ut ch ĠS endai ĠG a RF P Ġenh ancer art in Ġadap ter Ġfed eral pic illin Ġspot ted can onical Identi fication Ġaccompany ing F er G MP i ors l asting m ain Ġin her Ġin bred Ġd imethyl is ep os us ig er ĠI l ĠP N ĠN R inc ubation Cl ass Ġgr ant Ġquanti fying Ġinterfere s itiz ens athe red apol is Ġhamp ered 5 000 F ull W allis s ized it z Ġ( = Ġh anno ĠS han ĠI r ĠP CD ĠR a Ġdi ary oll a Ġam antadine Ġbi oph Ġ12 2 Ġread out Ġ13 2 Ġintern et Ġtail s ĠAss essment Ġexpon entially Ġhex on Ġdemyel inating Ġlam ina ĠPan el C ase C CR G APDH h l l ist Ġin ev ec e ĠP SG ĠR L Ġmic rol ĠW BC Ġperiod ic requ ency ator ial Ġaltern atively Ġcomorb idity Ġforec asting Ġconven ience Ġirre versible ĠCamb odia Ġbioch ar H aving ĠC Q ĠA BC ĠT m ĠL MP tim ately Ġqu e ĠK 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ĠBEC N ĠQueens land 3 22 B ody D AP P yr S ynthetic T ax c apsid d N i en Ġc aves Ġp GE Ġan ecd Ġd yn Ġv ibr Ġfor k ĠC EM ĠC LS ĠS ensitivity ĠI raq ĠA SP ib us ĠH op Ġim pressive Ġ3 80 Ġme als ĠN ex ĠN EAT ĠD ye Ġco invol ĠG BP ĠF MT Ġdi hyd all ergic yl es io virus reg ional Ġneg li other my not s Ġz oster Ġz oo Ġprof i 34 8 EM S tis sue ĠTr ust Ġ29 5 Ġglobal ization Ġtyp ed âĢ² ; Ġdistinct ly Ġbo ys ĠDC M infec tive Ġarg uing De ep ĠAS F Ġmismat ched Cal ves ĠSub strate Ġrecombin ase Gl n VE EV Ġcomprom ising Ġprefer ably Ġrecording s Ġvalut are Hy brid Ġimpl ants Ġanthrop ogenic Ġphyloge ographic pertil ion A ff B al B asic J apan M urine P lease U E c ation f ound l ic te ct Ġc ec Ġp CI el ph os te ĠC ong ĠC heng Ġres urg oc acy ĠS HP se p th ood ĠP FV Ġr t Ġr am Ġtr an ĠR osa ĠR RL ĠT TG Ġ3 90 ĠE ssential ĠN ature Ġ5 10 ĠB inding Ġcor nea Ġsp heres ĠK il ĠK aw ĠIn s ob tained AP S Ġu terus Ġinoc ulating Ġmonit ors Ġur inal Ġdam p com part Ġbronch us Ġmetabol omics here after 66 7 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