[CLS] @ sep @ polymerase chain reaction results on bone marrow for leishmania were positive . [SEP]

[CLS] @ sep @ serum is often frozen and bank ##ed for analysis at a later date . [SEP]

[CLS] ards @ARG@ causes @TRIGGER@ @ sep @ sepsis is one of the leading causes of ards . [SEP]

[CLS] @ sep @ diabetes mellitus was diagnosed and treatment with long ‐ acting insulin was started . [SEP]

[CLS] allowed @TRIGGER@ physician overr ##ide @ARG@ @ sep @ the algorithm also allowed for physician overr ##ide . [SEP]

[CLS] gluc ##os ##uria @ARG@ @ sep @ ur ##inal ##ysis revealed gluc ##os ##uria without keto ##n ##uria . [SEP]

ur ##inal ##ysis @ARG@ revealed @TRIGGER@ gluc ##os ##uria without keto ##n ##uria @ARG@ @OSP@

[CLS] db ##ci ##ca @ARG@ @ sep @ db ##ci ##ca is a very robust modeling method for hit identification . [SEP]

[CLS] systemic glucocorticoids @ARG@ treated @TRIGGER@ @ sep @ the cat had been treated with systemic glucocorticoids for several months . [SEP]

[CLS] infantile viral gastroenteritis @ARG@ cause @TRIGGER@ rotavirus @ARG@ @ sep @ rotavirus is a major cause of infantile viral gastroenteritis . [SEP]

[CLS] temperature @ARG@ storage time @ARG@ @ sep @ factors such as storage time and temperature should be considered when designing any retrospective study . [SEP]

[CLS] roles @TRIGGER@ lung fibrosis @ARG@ @ sep @ tgf - { \ \ beta } secreting treg cells play important roles in lung fibrosis . [SEP]

[CLS] pathophysiology of ards @ARG@ role @TRIGGER@ extracellular bacteria @ARG@ @ sep @ thus , extracellular bacteria play an important role in the pathophysiology of ards . [SEP]

[CLS] drug discovery @ARG@ vaccine development @ARG@ @ sep @ both vaccine development and drug discovery have been hampered by the inherent instability of the virus itself . [SEP]

vaccine development @ARG@ hampered @TRIGGER@ inherent instability of the virus @ARG@ @OSP@ drug discovery @ARG@ hampered @TRIGGER@ inherent instability of the virus @ARG@ @OSP@

[CLS] permitted @TRIGGER@ withdrawal of the insulin therapy @ARG@ hypoglycemic episodes @ARG@ @ sep @ three weeks later , hypoglycemic episodes permitted withdrawal of the insulin therapy . [SEP]

hypoglycemic episodes @ARG@ permitted @TRIGGER@ withdrawal of the insulin therapy @ARG@ @OSP@

[CLS] cause @TRIGGER@ respiratory deterioration @ARG@ exacerbations of underlying copd @ARG@ @ sep @ summary acute exacerbations of underlying copd are a common cause of respiratory deterioration . [SEP]

acute exacerbations of underlying copd @ARG@ cause @TRIGGER@ respiratory deterioration @ARG@ @OSP@

[CLS] @ sep @ histologic or antigenic detection of fh ##v - 1 was seen in 18 of 20 cats positive for fh ##v - 1 by qpcr . [SEP]

[CLS] protective immunity against viruses @ARG@ tlr3 @ARG@ role @TRIGGER@ @ sep @ data are conflicting on the role of tlr3 in protective immunity against viruses in the mouse model . [SEP]

[CLS] leading @TRIGGER@ ) @ARG@ respiratory failure @ARG@ @ sep @ acute respiratory distress syndrome ( ards ) is a very severe syndrome leading to respiratory failure and subsequent mortality . [SEP]

[CLS] waters ##hed contamination @ARG@ cattle from surface water @ARG@ reduce @TRIGGER@ @ sep @ restricting cattle from surface water during periods of high shedding may reduce waters ##hed contamination . [SEP]

restricting cattle from surface water @ARG@ reduce @TRIGGER@ waters ##hed contamination @ARG@ @OSP@

[CLS] amplified @TRIGGER@ vp1 / 2 gene in positive samples @ARG@ pcr @ARG@ @ sep @ the vp1 / 2 gene in positive samples was then amplified by pcr and sequenced . [SEP]

[CLS] examined @TRIGGER@ histopathology @ARG@ respiratory tract tissues @ARG@ @ sep @ necropsy was performed on all cats , and a complete set of respiratory tract tissues was examined by histopathology . [SEP]

[CLS] crc ##ov antigen @ARG@ elisa @ARG@ based @TRIGGER@ immunofluorescence assay @ARG@ @ sep @ the development of an elisa based on crc ##ov antigen and immunofluorescence assay are described here . [SEP]

[CLS] melting ulcers @ARG@ corneal perforation @ARG@ progressed @TRIGGER@ @ sep @ although specific topical treatment was applied , melting ulcers progressed to corneal perforation and both eyes were en ##ucleated . [SEP]

[CLS] human and financial losses @ARG@ mitigate @TRIGGER@ @ sep @ abstract in order to mitigate human and financial losses as a result of future global pandemic ##s , we must plan now . [SEP]

human and financial losses @ARG@ result @TRIGGER@ future global pandemic ##s @ARG@ @OSP@

[CLS] fi ##pv - specific antibodies @ARG@ @ sep @ vaccinated kit ##ten ##s developed fi ##pv - specific antibodies after immunization , however , none of them was protected against fi ##pv . [SEP]

[CLS] @ sep @ ocular histology showed large numbers of intracellular organisms compatible with am ##astigotes of the genus leishmania located in the uve ##al tract , cornea , scler ##a and retina . [SEP]

intracellular organisms compatible with am ##astigotes of the genus leishmania @ARG@ located @TRIGGER@ uve ##al tract @ARG@ @OSP@ intracellular organisms compatible with am ##astigotes of the genus leishmania @ARG@ located @TRIGGER@ cornea @ARG@ @OSP@ intracellular organisms compatible with am ##astigotes of the genus leishmania @ARG@ located @TRIGGER@ scler ##a @ARG@ @OSP@ intracellular organisms compatible with am ##astigotes of the genus leishmania @ARG@ located @TRIGGER@ retina @ARG@ @OSP@

[CLS] compounds @ARG@ targeting @TRIGGER@ hiv infections @ARG@ @ sep @ new compounds are in clinical development or under preclinical evaluation , and , again , half of these are targeting hiv infections . [SEP]

[CLS] kill @TRIGGER@ h . som ##ni @ARG@ @ sep @ previously , it has been reported that bovine neutrophils and macrophages have limited ability to phagocyt ##ose and kill h . som ##ni . [SEP]

[CLS] fi ##pv 79 - 114 ##6 challenge @ARG@ vaccine @ARG@ @ sep @ the vaccine was then tested in cats to evaluate its efficacy in an fi ##pv 79 - 114 ##6 challenge . [SEP]

[CLS] virus attenuation @ARG@ led @TRIGGER@ higher host interferon responses @ARG@ @ sep @ deletions in the carboxy - terminal region of nsp ##1 protein led to higher host interferon responses and virus attenuation . [SEP]

deletions in the carboxy - terminal region of nsp ##1 protein @ARG@ led @TRIGGER@ higher host interferon responses and virus attenuation @ARG@ @OSP@

[CLS] inhibit @TRIGGER@ development of an efficient immune response to the virus @ARG@ @ sep @ this preferential infection of mature dcs may inhibit the development of an efficient immune response to the virus . [SEP]

preferential infection of mature dcs @ARG@ inhibit @TRIGGER@ development of an efficient immune response @ARG@ @OSP@

[CLS] killed @TRIGGER@ h . som ##ni @ARG@ trapped @TRIGGER@ bovine neutrophils @ARG@ @ sep @ further analyses demonstrated that bovine neutrophils trapped and killed h . som ##ni in a dna - dependent manner . [SEP]

[CLS] early administration of cid ##ofovir @ARG@ lower hazard for respiratory failure development @ARG@ associated @TRIGGER@ @ sep @ conclusions early administration of cid ##ofovir was associated with a lower hazard for respiratory failure development . [SEP]

early administration of cid ##ofovir @ARG@ associated @TRIGGER@ lower hazard for respiratory failure development @ARG@ @OSP@

[CLS] produced @TRIGGER@ outer membrane vesicles @ARG@ extracellular traps @ARG@ @ sep @ neutrophil extracellular traps were produced in response to outer membrane vesicles , but not lip ##ool ##igo ##sa ##cc ##hr ##ide alone . [SEP]

[CLS] h . som ##ni cells @ARG@ caused @TRIGGER@ macrophage extracellular trap formation @ARG@ @ sep @ treatment of bovine monocyte - derived macrophages with h . som ##ni cells also caused macrophage extracellular trap formation . [SEP]

[CLS] cell culture @ARG@ virus fitness in vitro @ARG@ chimeric proteins @ARG@ increased @TRIGGER@ generated @TRIGGER@ @ sep @ the chimeric proteins generated in cell culture increased virus fitness in vitro but remained attenuated in mice . [SEP]

chimeric proteins generated in cell culture @ARG@ increased @TRIGGER@ virus fitness @ARG@ @OSP@

[CLS] sars - cov infection @ARG@ recovery @TRIGGER@ t - cell immunity @ARG@ @ sep @ it has been confirmed that t - cell immunity plays an important role in recovery from sars - cov infection . [SEP]

t - cell immunity @ARG@ role @TRIGGER@ recovery from sars - cov infection @ARG@ @OSP@

[CLS] assessed @TRIGGER@ performance @ARG@ @ sep @ diagnostic performance was assessed with 103 rnas from suspected cases ( 40 positive and 63 negative results ) previously analyzed with a reference real - time pcr technique . [SEP]

[CLS] treatment of severe acute respiratory syndrome ( sars ) @ARG@ @ sep @ abstract treatment of severe acute respiratory syndrome ( sars ) is experimental , and the effectiveness of ribavirin - steroid therapy is unclear . [SEP]

treatment @TRIGGER@ severe acute respiratory syndrome ( sars ) @ARG@ ribavirin - steroid therapy @ARG@ @OSP@

[CLS] diseases and conditions @ARG@ vaccines @ARG@ drug delivery @ARG@ @ sep @ supramolecular materials composed of proteins and peptides have been receiving considerable attention towards a range of diseases and conditions from vaccines to drug delivery . [SEP]

[CLS] virus serology @ARG@ virus isolation @ARG@ immunohistochemistry @ARG@ @ sep @ all pigs of groups a and c became infected with prrsv , according to virological techniques used ( immunohistochemistry , virus isolation and virus serology ) . [SEP]

[CLS] sec ##12 ##p @ARG@ essential @TRIGGER@ formation of transport vesicles @ARG@ @ sep @ yeast sec ##12 ##p is a type ii transmembrane protein in the er , which is essential for the formation of transport vesicles . [SEP]

[CLS] secondary glaucoma @ARG@ deep stromal corneal ulcers @ARG@ exud ##ative pan ##uv ##eit ##is @ARG@ @ sep @ initial ophthalmic examination revealed bilateral deep stromal corneal ulcers , exud ##ative pan ##uv ##eit ##is and secondary glaucoma . [SEP]

[CLS] pneumonia @ARG@ mycoplasma pneumoniae @ARG@ due @TRIGGER@ @ sep @ here , we describe a typical case of pneumonia due to mycoplasma pneumoniae in a young adult with mild pha ##ry ##ng ##itis as the leading symptom . [SEP]

[CLS] sn ##ee ##zes @ARG@ laser particle size analyse ##r @ARG@ measured @TRIGGER@ @ sep @ twenty healthy subjects participated in the experiment and 44 sn ##ee ##zes were measured by using a laser particle size analyse ##r . [SEP]

sn ##ee ##zes @ARG@ measured @TRIGGER@ laser particle size analyse ##r @ARG@ @OSP@

[CLS] prevent @TRIGGER@ cid ##ofovir @ARG@ respiratory failure @ARG@ @ sep @ it is suggested that cid ##ofovir be administered within 7 days from symptom onset to prevent respiratory failure in patients with potentially severe had ##v pneumonia . [SEP]

cid ##ofovir be administered within 7 days from symptom onset @ARG@ prevent @TRIGGER@ respiratory failure in patients with potentially severe had ##v pneumonia @ARG@ @OSP@

[CLS] immunoglobulin responses @ARG@ protection @TRIGGER@ infectious pathogens @ARG@ human vaccines @ARG@ generation @TRIGGER@ @ sep @ to date , the majority of licensed human vaccines afford protection against infectious pathogens through the generation of specific immunoglobulin responses . [SEP]

[CLS] treatment @TRIGGER@ compounds @ARG@ hiv infections @ARG@ @ sep @ more than 40 compounds have been formally licensed for clinical use as antiviral drugs , and half of these are used for the treatment of hiv infections . [SEP]

[CLS] patient ’ s peculiar clinical conditions @ARG@ therapeutic options @ARG@ tailored @TRIGGER@ @ sep @ in most cases , therapeutic options , both local and systemic , should be tailored to the patient ’ s peculiar clinical conditions . [SEP]

therapeutic options @ARG@ tailored @TRIGGER@ patient ’ s peculiar clinical conditions @ARG@ @OSP@

[CLS] generated @TRIGGER@ intermediate during viral replication @ARG@ double - stranded rna ( dsrna ) @ARG@ @ sep @ in virus - infected cells , double - stranded rna ( dsrna ) is generated as an intermediate during viral replication . [SEP]

double - stranded rna ( dsrna ) @ARG@ generated @TRIGGER@ viral replication @ARG@ @OSP@

[CLS] leishmaniasis @ARG@ enzyme [UNK] linked immunosorbent assay @ARG@ positive @TRIGGER@ treatment with allop ##urin ##ol @ARG@ @ sep @ an enzyme ‐ linked immunosorbent assay was highly positive for leishmaniasis , and treatment with allop ##urin ##ol was started . [SEP]

[CLS] host genotype @ARG@ mhv strain @ARG@ depend @TRIGGER@ @ sep @ transmission of mouse hepatitis virus ( mhv ) in utero following oro ##nas ##al inoculation of pregnant mice was found to depend upon mhv strain and host genotype . [SEP]

[CLS] viruses @ARG@ human respiratory tract @ARG@ contribute @TRIGGER@ entry @TRIGGER@ annual deaths worldwide @ARG@ @ sep @ the human respiratory tract is the entry point for over 200 known viruses that collectively contribute to millions of annual deaths worldwide . [SEP]

[CLS] acute and chronic demyelinating diseases in mice @ARG@ acute encephalitis @ARG@ causes @TRIGGER@ @ sep @ mouse hepatitis virus strain jh ##m ( mhv - jh ##m ) causes acute encephalitis and acute and chronic demyelinating diseases in mice . [SEP]

[CLS] economic losses to pig producers @ARG@ caused @TRIGGER@ porcine epidemic diarrhea virus ( ped ##v ) @ARG@ @ sep @ abstract porcine epidemic diarrhea virus ( ped ##v ) has caused extensive economic losses to pig producers in many countries . [SEP]

porcine epidemic diarrhea virus ( ped ##v ) @ARG@ caused @TRIGGER@ economic losses to pig producers @ARG@ @OSP@

[CLS] mhv subgen ##omic mrna transcription @ARG@ regulate @TRIGGER@ interactions between leader rna and transcriptional initiation sequences @ARG@ @ sep @ these findings strengthened the theory that interactions between leader rna and transcriptional initiation sequences regulate mhv subgen ##omic mrna transcription . [SEP]

interactions between leader rna and transcriptional initiation sequences @ARG@ regulate @TRIGGER@ mhv subgen ##omic mrna transcription @ARG@ @OSP@

[CLS] increase @TRIGGER@ attenuating mutations into the nsp ##1 protein @ARG@ vaccine bios ##afe ##ty @ARG@ introduced @TRIGGER@ @ sep @ in addition , to increase vaccine bios ##afe ##ty , we introduced additional attenuating mutations into the nsp ##1 protein . [SEP]

increase @TRIGGER@ vaccine bios ##afe ##ty @ARG@ attenuating mutations into the nsp ##1 protein @ARG@ @OSP@

[CLS] @ sep @ here , we estimate r using daily case notification ##s during the autumn wave of the influenza pandemic ( spanish flu ) in the city of san francisco , california , from 191 ##8 to 191 ##9 . [SEP]

[CLS] previously unknown pathogens @ARG@ string - of - epitope vaccines @ARG@ for @TRIGGER@ @ sep @ these new tools have the potential to significantly reduce the time needed to design string - of - epitope vaccines for previously unknown pathogens . [SEP]

string - of - epitope vaccines @ARG@ for @TRIGGER@ previously unknown pathogens @ARG@ @OSP@

[CLS] alter @TRIGGER@ cellular phenotype of the host cell @ARG@ pathogens @ARG@ target @TRIGGER@ structural and signaling lipids @ARG@ @ sep @ bacterial and viral pathogens target predominantly structural and signaling lipids to alter the cellular phenotype of the host cell . [SEP]

bacterial and viral pathogens @ARG@ target @TRIGGER@ predominantly structural and signaling lipids @ARG@ @OSP@ bacterial and viral pathogens @ARG@ alter @TRIGGER@ cellular phenotype of the host cell @ARG@ @OSP@

[CLS] severe bronch ##op ##neum ##onia in cattle @ARG@ h . som ##ni @ARG@ causes @TRIGGER@ @ sep @ h . som ##ni is a member of the bovine respiratory disease complex that causes severe bronch ##op ##neum ##onia in cattle . [SEP]

h . som ##ni @ARG@ causes @TRIGGER@ severe bronch ##op ##neum ##onia in cattle @ARG@ @OSP@

[CLS] host response to h . som ##ni infection in cattle @ARG@ role @TRIGGER@ extracellular traps @ARG@ @ sep @ these findings suggest that extracellular traps may play a role in the host response to h . som ##ni infection in cattle . [SEP]

extracellular traps @ARG@ role @TRIGGER@ host response to h . som ##ni infection in cattle @ARG@ @OSP@

[CLS] formation @TRIGGER@ viral factor ##ies @ARG@ supplying @TRIGGER@ @ sep @ mitochondria , cytoplasmic membranes and cytoskeletal components frequently participate in the formation of viral factor ##ies , supplying basic and common needs for key steps in the viral replication cycle . [SEP]

[CLS] against @TRIGGER@ infection @ARG@ igg antibodies against the surface protein @ARG@ vaccination attempts @ARG@ fi ##pv @ARG@ enhance @TRIGGER@ @ sep @ most previous vaccination attempts against fi ##pv were unsuccessful because igg antibodies against the surface protein enhance the infection . [SEP]

[CLS] kap ##osi ' s sarcoma ( ks ) @ARG@ @ sep @ abstract kap ##osi ' s sarcoma ( ks ) , an angio ##proliferative disorder , has a viral etiology and a multifactorial pathogenesis hinge ##d on an immune dysfunction . [SEP]

multifactorial pathogenesis @ARG@ hinge ##d @TRIGGER@ immune dysfunction @ARG@ @OSP@ kap ##osi ' s sarcoma ( ks ) @ARG@ hinge ##d @TRIGGER@ immune dysfunction @ARG@ @OSP@

[CLS] @ARG@ introduce @TRIGGER@ @ sep @ site - directed mutagenesis in vitro was used to introduce stop codons in the genomic dna of the alpha and beta chains of the murine class ii major histocompatibility complex antigen , i - ak . [SEP]

vitro @ARG@ used @TRIGGER@ introduce stop codons in the genomic dna of the alpha and beta chains of the murine class ii major histocompatibility complex antigen @ARG@ @OSP@

[CLS] detrimental host response @ARG@ acute and chronic inflammatory diseases @ARG@ induce @TRIGGER@ @ sep @ viral infections frequently induce acute and chronic inflammatory diseases , yet the contribution of the innate immune response to a detrimental host response remains poorly understood . [SEP]

[CLS] @ sep @ patients with potentially severe had ##v pneumonia with risk factors for respiratory failure were included and divided into early ( within 7 days from symptom onset ) and delayed ( after 7 days from symptom onset ) treatment groups . [SEP]

[CLS] pcr products @ARG@ assay @ARG@ detection @TRIGGER@ pcr method @ARG@ based @TRIGGER@ dip ##st ##ick device @ARG@ @ sep @ the assay is based on a pcr method coupled to detection of pcr products by means of a dip ##st ##ick device . [SEP]

pcr method coupled to detection of pcr products @ARG@ by @TRIGGER@ dip ##st ##ick device @ARG@ @OSP@ the assay @ARG@ based @TRIGGER@ pcr method coupled to detection of pcr products @ARG@ @OSP@

[CLS] tested @TRIGGER@ np - 1 @ARG@ qpcr @ARG@ nsp ##1 @ARG@ for @TRIGGER@ @ sep @ nasopharyngeal samples from 300 patients , previously screened for common respiratory viruses , were tested by qpcr for the nsp ##1 and np - 1 genes . [SEP]

[CLS] serotype 1 ibd ##v strains @ARG@ serotype 2 ibd ##v strain @ARG@ probe @ARG@ detect @TRIGGER@ @ sep @ the probe had broad specificity and was used to detect four serotype 1 ibd ##v strains and one serotype 2 ibd ##v strain . [SEP]

[CLS] cd8 t cells in vitro @ARG@ mhv - jh ##m infection @ARG@ impaired @TRIGGER@ function @ARG@ stimulation @TRIGGER@ @ sep @ dc function was impaired after mhv - jh ##m infection , resulting in decreased stimulation of cd8 t cells in vitro . [SEP]

[CLS] mediated @TRIGGER@ fatal systemic disease @ARG@ induces @TRIGGER@ inappropriate immune response @ARG@ ) @ARG@ @ sep @ abstract feline infectious peritonitis virus ( fi ##pv ) is a coron ##avirus that induces a fatal systemic disease mediated by an inappropriate immune response . [SEP]

feline infectious peritonitis virus ( fi ##pv ) @ARG@ induces @TRIGGER@ fatal systemic disease @ARG@ @OSP@ fatal systemic disease @ARG@ mediated @TRIGGER@ inappropriate immune response @ARG@ @OSP@

[CLS] effects @ARG@ membrane microdom ##ains @ARG@ assembly @ARG@ reduce @TRIGGER@ enhance @TRIGGER@ lipid rafts @ARG@ @ sep @ we find several mechanisms by which membrane microdom ##ains , such as lipid rafts , reduce these effects , and thus , enhance assembly . [SEP]

[CLS] air travel @ARG@ emerging infections @ARG@ pandemic ##s @ARG@ infectious disease spread @ARG@ conduit @TRIGGER@ @ sep @ serving over three billion passenger ##s annually , air travel serves as a conduit for infectious disease spread , including emerging infections and pandemic ##s . [SEP]

[CLS] associated @TRIGGER@ treatment @ARG@ lower 21 - day probability of respiratory failure @ARG@ @ sep @ early treatment was associated with a lower 21 - day probability of respiratory failure by the kaplan – meier method ( p < 0 . 001 ) . [SEP]

[CLS] novel virus @ARG@ sars coron ##avirus ( sars - cov ) @ARG@ ) @ARG@ caused @TRIGGER@ @ sep @ severe acute respiratory syndrome ( sars ) was caused by a novel virus now known as sars coron ##avirus ( sars - cov ) . [SEP]

) @ARG@ caused @TRIGGER@ sars coron ##avirus ( sars - cov ) @ARG@ @OSP@

[CLS] nanostructures of type i collagen films @ARG@ affect @TRIGGER@ collagen – stroma interactions @ARG@ stem colony formation @ARG@ @ sep @ our results indicate that the nanostructures of type i collagen films primarily affect stem colony formation through the collagen – stroma interactions . [SEP]

the nanostructures of type i collagen films @ARG@ affect @TRIGGER@ stem colony formation through the collagen – stroma interactions @ARG@ @OSP@

[CLS] derived @TRIGGER@ bacterial communities @ARG@ environmental general ##ist bacteria @ARG@ human skin and oral commensal ##s @ARG@ @ sep @ we found that bacterial communities were largely derived from human skin and oral commensal ##s , as well as environmental general ##ist bacteria . [SEP]

[CLS] triggered @TRIGGER@ severe acute respiratory syndrome ( sars ) @ARG@ global alert for coron ##avirus infections @ARG@ @ sep @ abstract over 12 years have elapsed since severe acute respiratory syndrome ( sars ) triggered the first global alert for coron ##avirus infections . [SEP]

severe acute respiratory syndrome ( sars ) @ARG@ triggered @TRIGGER@ global alert for coron ##avirus infections @ARG@ @OSP@

[CLS] th17 - like innate immunity @ARG@ etiology of ards @ARG@ extracellular bacteria @ARG@ account @TRIGGER@ neutrophil activation @ARG@ triggered @TRIGGER@ @ sep @ thus , extracellular bacteria triggered th17 - like innate immunity with neutrophil activation might accounts for the etiology of ards . [SEP]

[CLS] morbidity and mortality @ARG@ results @TRIGGER@ causes @TRIGGER@ severe acute respiratory syndrome @ARG@ @ sep @ cov ##id - 19 is an emerging and rapidly evolving pandemic around the world , which causes severe acute respiratory syndrome and results in substantial morbidity and mortality . [SEP]

[CLS] human infections of sars coron ##avirus ( sars - cov ) @ARG@ @ sep @ virus transmission in humans was quickly hal ##ted by public health measures and human infections of sars coron ##avirus ( sars - cov ) have not been observed since . [SEP]

[CLS] efficient frameshift ##ing @ARG@ virus infection @ARG@ dependent @TRIGGER@ tme ##v - based reporter constructs in transfected cells @ARG@ @ sep @ furthermore , in tme ##v - based reporter constructs in transfected cells , efficient frameshift ##ing is critically dependent upon virus infection . [SEP]

[CLS] identification @TRIGGER@ new potential public health pathogens @ARG@ biod ##ef ##ense surveillance capability @ARG@ @ sep @ increased biod ##ef ##ense surveillance capability has dramatically improved , while new tools and increased awareness have foster ##ed rapid identification of new potential public health pathogens . [SEP]

increased awareness @ARG@ foster ##ed @TRIGGER@ rapid identification of new potential public health pathogens @ARG@ @OSP@ new tools @ARG@ foster ##ed @TRIGGER@ rapid identification of new potential public health pathogens @ARG@ @OSP@

[CLS] hk ##u ##4 [UNK] cov and mers [UNK] cov 3c ##l ( pro ) inhibition @ARG@ tested @TRIGGER@ hits @ARG@ @ sep @ the identified hits were tested for hk ##u ##4 ‐ cov and mers ‐ cov 3c ##l ( pro ) inhibition . [SEP]

the identified hits @ARG@ tested @TRIGGER@ hk ##u ##4 ‐ cov and mers ‐ cov 3c ##l ( pro ) inhibition @ARG@ @OSP@

[CLS] formation of the viral factor ##y @ARG@ complex interactions and signalling events between viral and cell factors @ARG@ involves @TRIGGER@ @ sep @ the formation of the viral factor ##y involves a number of complex interactions and signalling events between viral and cell factors . [SEP]

formation of the viral factor ##y @ARG@ involves @TRIGGER@ interactions and signalling events between viral and cell factors @ARG@ @OSP@

[CLS] mers coron ##avirus 3c ##l ( pro ) inhibitors development @ARG@ phenyl ##sulf ##ona ##mid ##e scaffold @ARG@ @ sep @ the phenyl ##sulf ##ona ##mid ##e scaffold represents a potential starting point for mers coron ##avirus 3c ##l ( pro ) inhibitors development . [SEP]

phenyl ##sulf ##ona ##mid ##e scaffold @ARG@ mers coron ##avirus 3c ##l ( pro ) inhibitors @ARG@ development @TRIGGER@ @OSP@

[CLS] against @TRIGGER@ effective immune response @ARG@ pox ##viral promoter @ARG@ induce @TRIGGER@ fi ##pv @ARG@ @ sep @ our results suggest a crucial role for the type of pox ##viral promoter that must be used to induce an effective immune response against fi ##pv . [SEP]

pox ##viral promoter @ARG@ induce @TRIGGER@ immune response against fi ##pv @ARG@ @OSP@

[CLS] lipids @ARG@ allowing @TRIGGER@ visualization of differences between different types of pathogens @ARG@ pathogens @ARG@ target @TRIGGER@ interaction maps @ARG@ @ sep @ different types of pathogens target different lipids as shown in interaction maps , allowing visualization of differences between different types of pathogens . [SEP]

[CLS] t - cell - mediated immune responses @ARG@ costimulatory pathways @ARG@ regulating @TRIGGER@ @ sep @ in recent years , the selective manipulation of specific costimulatory pathways , which are critical in regulating t - cell - mediated immune responses , has generated increasing interest . [SEP]

costimulatory pathways @ARG@ regulating @TRIGGER@ t - cell - mediated immune responses @ARG@ @OSP@

[CLS] hhv - 8 infection @ARG@ required @TRIGGER@ @ sep @ in fact , hhv - 8 infection can be considered a necessary but not sufficient condition for the development of ks , because further factors ( genetic , immunologic , and environmental ) are required . [SEP]

[CLS] suspected respiratory tract infections @ARG@ evaluate @TRIGGER@ molecular methods @ARG@ @ sep @ based on the results obtained , the molecular methods represent a valid and rapid tool for clinical management and should be included in diagnostic panels aimed to evaluate suspected respiratory tract infections . [SEP]

[CLS] trapped @TRIGGER@ h . som ##ni cells @ARG@ scanning electron microscopy @ARG@ web - like structure @ARG@ confocal microscopy @ARG@ @ sep @ using scanning electron microscopy and confocal microscopy , we observed h . som ##ni cells trapped within a web - like structure . [SEP]

confocal microscopy @ARG@ observed @TRIGGER@ h . som ##ni cells trapped within a web - like structure @ARG@ @OSP@ scanning electron microscopy @ARG@ observed @TRIGGER@ h . som ##ni cells trapped within a web - like structure @ARG@ @OSP@

[CLS] coarse - grained model @ARG@ molecular dynamics simulations @ARG@ virus assembly on a fluctuating lipid membrane @ARG@ @ sep @ to this end , we have performed molecular dynamics simulations on a coarse - grained model that describes virus assembly on a fluctuating lipid membrane . [SEP]

[CLS] autophagosome formation @ARG@ leads @TRIGGER@ mediate @TRIGGER@ @ sep @ despite the advances in understanding the functions of autophagy and the identification of several factors , named atg proteins that mediate it , the mechanism that leads to autophagosome formation is still a mys ##ter ##y . [SEP]

[CLS] viral infections @ARG@ bacterial @ARG@ associated @TRIGGER@ myx ##ovirus resistance protein a ( mx ##a ) @ARG@ @ sep @ c - reactive protein ( crp ) and myx ##ovirus resistance protein a ( mx ##a ) are associated with bacterial and viral infections , respectively . [SEP]

) @ARG@ associated @TRIGGER@ bacterial and viral infections @ARG@ @OSP@ myx ##ovirus resistance protein a ( mx ##a ) @ARG@ associated @TRIGGER@ bacterial and viral infections @ARG@ @OSP@

[CLS] against @TRIGGER@ immune responses @ARG@ virus infection @ARG@ serves @TRIGGER@ vaccine antigen @ARG@ whole virion @ARG@ analysis @TRIGGER@ @ sep @ in general , a whole virion serves as a simple vaccine antigen and often essential material for the analysis of immune responses against virus infection . [SEP]

whole virion @ARG@ serves @TRIGGER@ simple vaccine antigen @ARG@ @OSP@ whole virion @ARG@ serves @TRIGGER@ material for the analysis of immune responses @ARG@ @OSP@ material for the analysis of immune responses @ARG@ against @TRIGGER@ virus infection @ARG@ @OSP@

[CLS] analyzed @TRIGGER@ automated dry - slide chemistry analyzer @ARG@ @ sep @ samples were analyzed by using an automated dry - slide chemistry analyzer at time 0 and then stored as aliquots for analysis at time points including day 7 , 30 , 90 , and 360 . [SEP]

[CLS] essential @TRIGGER@ viral replication @ARG@ 3c [UNK] like protease ( 3c ##l ( pro ) ) @ARG@ @ sep @ the 3c ‐ like protease ( 3c ##l ( pro ) ) is essential for viral replication and thus represents a potential target for antiviral drug development . [SEP]

3c ‐ like protease ( 3c ##l ( pro ) ) @ARG@ target @TRIGGER@ antiviral drug development @ARG@ @OSP@

[CLS] hcv @ARG@ viral pathogens @ARG@ hemorrhagic fever viruses @ARG@ hpv @ARG@ @ sep @ yet , quite a number of important viral pathogens ( i . e . hpv , hcv , hemorrhagic fever viruses ) remain in need of effective and / or improved antiviral therapies . [SEP]

[CLS] mutated @TRIGGER@ encode @TRIGGER@ pb ##m @ARG@ sars - cov - [UNK] e protein 8a @ARG@ @ sep @ similarly , after passage in mice , sars - cov - ∆ ##e protein 8a mutated , to now encode a pb ##m , and also reg ##ained virulence . [SEP]

[CLS] pathogenesis of respiratory tract infections @ARG@ involved @TRIGGER@ para ##infl ##ue ##n ##za viruses ( hpi ##vs ) @ARG@ @ sep @ abstract human para ##infl ##ue ##n ##za viruses ( hpi ##vs ) are distributed worldwide and are involved mainly in the pathogenesis of respiratory tract infections . [SEP]

human para ##infl ##ue ##n ##za viruses ( hpi ##vs ) @ARG@ involved @TRIGGER@ pathogenesis of respiratory tract infections @ARG@ @OSP@

[CLS] reversion to a virulent phenotype @ARG@ mutated variant of 8a protein @ARG@ resulting @TRIGGER@ @ sep @ in contrast , during sars - cov - ∆ ##e passage in mice , the virus incorporated a mutated variant of 8a protein , resulting in reversion to a virulent phenotype . [SEP]

[CLS] increase @TRIGGER@ dl ##at @ARG@ @ sep @ removing all amino acids of the cytoplasmic domains of both the alpha and beta chains resulted in a 10 - fold increase in the dl ##at , the highest value for any of the truncated i - ak molecules tested . [SEP]

[CLS] compensate @TRIGGER@ requires @TRIGGER@ removal of this motif from the e protein @ARG@ pb ##m on a transmembrane protein @ARG@ @ sep @ these data indicated that the virus requires a pb ##m on a transmembrane protein to compensate for removal of this motif from the e protein . [SEP]

the virus @ARG@ requires @TRIGGER@ pb ##m on a transmembrane protein @ARG@ @OSP@

[CLS] bayesian analysis @ARG@ estimated @TRIGGER@ ring trial results obtained with the different assays @ARG@ @ sep @ the sensitivity and specificity of each assay has been estimated using a bayesian analysis applied to the ring trial results obtained with the different assays in the absence of a gold standard . [SEP]

sensitivity and specificity of each assay @ARG@ estimated @TRIGGER@ bayesian analysis @ARG@ @OSP@ bayesian analysis @ARG@ applied @TRIGGER@ ring trial results obtained with the different assays @ARG@ @OSP@

[CLS] mhv challenge @ARG@ against * trigger both arg * antigenic ##ally homo ##typ ##ic and hetero ##typ ##ic strains of mhv @ARG@ protective @TRIGGER@ @ sep @ immunity to mhv challenge was cross - protective against both antigenic ##ally homo ##typ ##ic and hetero ##typ ##ic strains of mhv . [SEP]

immunity to mhv challenge @ARG@ protective @TRIGGER@ against both antigenic ##ally homo ##typ ##ic and hetero ##typ ##ic strains of mhv @ARG@ @OSP@

[CLS] produce @TRIGGER@ mannheim ##ia haem ##olytica @ARG@ extracellular traps @ARG@ bovine neutrophils and macrophages @ARG@ response @TRIGGER@ @ sep @ recently , it was discovered that bovine neutrophils and macrophages produce extracellular traps in response to mannheim ##ia haem ##olytica , another member of the bovine respiratory disease complex . [SEP]

[CLS] antiviral vaccine @ARG@ developing @TRIGGER@ penetrate @TRIGGER@ hard - to - reach organs @ARG@ therapeutic viruses @ARG@ @ sep @ these observations have potential implications for antiviral vaccine development and for the design of cancer therapeutics in terms of developing therapeutic viruses that penetrate hard - to - reach organs . [SEP]

[CLS] mutating the g _ gu ##u _ u ##uu shift site @ARG@ inhibit @TRIGGER@ frameshift ##ing @ARG@ @ sep @ mutating the g _ gu ##u _ u ##uu shift site to inhibit frameshift ##ing results in an attenuated virus with reduced growth kinetics and a small - plaque phenotype . [SEP]

site @ARG@ inhibit @TRIGGER@ frameshift ##ing @ARG@ @OSP@ site @ARG@ results @TRIGGER@ attenuated virus with reduced growth kinetics and a small - plaque phenotype @ARG@ @OSP@

[CLS] unwanted structures @ARG@ role @TRIGGER@ eliminate @TRIGGER@ induced @TRIGGER@ physiological processes @ARG@ pathological situations @ARG@ @ sep @ as a result , this pathway plays an active role in many physiological processes , and it is induced in numerous pathological situations because of its ability to rapidly eliminate unwanted structures . [SEP]

[CLS] host cells @ARG@ replicate @TRIGGER@ pathogens @ARG@ sub ##vert @TRIGGER@ autophagy @ARG@ @ sep @ the information acquired investigating the pathogens that sub ##vert autophagy in order to replicate in the host cells will also be discussed because it could provide important hint ##s for solving this mys ##ter ##y . [SEP]

[CLS] increase @TRIGGER@ genetic stability of the vaccine candidate @ARG@ @ sep @ to increase the genetic stability of the vaccine candidate , we introduced small attenuating deletions in e gene that did not affect the endogenous pb ##m , preventing the incorporation of novel chimeric proteins in the virus genome . [SEP]

increase @TRIGGER@ genetic stability of the vaccine candidate @ARG@ small attenuating deletions in e gene @ARG@ @OSP@ small attenuating deletions in e gene @ARG@ preventing @TRIGGER@ incorporation of novel chimeric proteins in the virus genome @ARG@ @OSP@

[CLS] against @TRIGGER@ technical indicators @ARG@ ventilated protective clothing @ARG@ gas - tight chemical protective clothing @ARG@ particulate radioactive contamination @ARG@ @ sep @ we also analyzed the technical indicators of the gas - tight chemical protective clothing and ventilated protective clothing against particulate radioactive contamination which closely related to ppb ##pc . [SEP]

gas - tight chemical protective clothing @ARG@ against @TRIGGER@ particulate radioactive contamination @ARG@ @OSP@ ventilated protective clothing @ARG@ against @TRIGGER@ particulate radioactive contamination @ARG@ @OSP@

[CLS] hk ##u ##4 [UNK] cov 3c ##l ( pro ) @ARG@ @ sep @ hk ##u ##4 ‐ cov 3c ##l ( pro ) shares high sequence identity ( 81 % ) with the mers ‐ cov enzyme and thus represents a potential surrogate model for anti ‐ mers drug discovery . [SEP]

) @ARG@ represents @TRIGGER@ surrogate model for anti ‐ mers drug discovery @ARG@ @OSP@

[CLS] e3 region @ARG@ @ sep @ abstract the e3 region of all simian and human types classified within species human mast ##aden ##ovirus b ( had ##v - b ) encodes two unique highly conserved orfs of unknown function designated e3 - cr ##1 ##β and e3 - cr ##1 ##γ . [SEP]

e3 region of all simian and human types classified within species human mast ##aden ##ovirus b ( had ##v - b ) @ARG@ encodes @TRIGGER@ highly conserved orfs @ARG@ @OSP@ e3 region of all simian and human types classified within species human mast ##aden ##ovirus b ( had ##v - b ) @ARG@ encodes @TRIGGER@ e3 - cr ##1 ##β @ARG@ @OSP@ e3 region of all simian and human types classified within species human mast ##aden ##ovirus b ( had ##v - b ) @ARG@ encodes @TRIGGER@ e3 - cr ##1 ##γ @ARG@ @OSP@

[CLS] delivered @TRIGGER@ large double [UNK] membrane vesicles called autophagosomes @ARG@ destroyed @TRIGGER@ lysosome / vacuole @ARG@ cytoplasmic components @ARG@ sequestered @TRIGGER@ @ sep @ during starvation , cytoplasmic components are randomly sequestered into large double ‐ membrane vesicles called autophagosomes and delivered into the lysosome / vacuole where they are destroyed . [SEP]

[CLS] nsp ##4 - egfp @ARG@ er - golgi intermediate compartment ( erg ##ic ) marker erg ##ic - 53 @ARG@ colocalized @TRIGGER@ @ sep @ only a small fraction of nsp ##4 - egfp colocalized with the er - golgi intermediate compartment ( erg ##ic ) marker erg ##ic - 53 . [SEP]

nsp ##4 - egfp @ARG@ colocalized @TRIGGER@ er - golgi intermediate compartment ( erg ##ic ) marker erg ##ic - 53 @ARG@ @OSP@

[CLS] 3c ##l ( pro ) @ARG@ highlights @ARG@ mers [UNK] cov @ARG@ @ sep @ highlights : mers ‐ cov is an emerging virus that is closely related to the bat hk ##u ##4 ‐ cov . 3c ##l ( pro ) is a potential drug target for coron ##avirus infection . [SEP]

[CLS] antioxidant therapy @ARG@ sildenafil @ARG@ result @TRIGGER@ cardiovascular protection @ARG@ pharmacological inhibitor of phosphodiesterase 5 ( pde ##5 ) @ARG@ @ sep @ background : the pharmacological inhibitor of phosphodiesterase 5 ( pde ##5 ) , sildenafil , is a promising candidate for antioxidant therapy that can result in cardiovascular protection . [SEP]

[CLS] threat @TRIGGER@ coron ##aviruses @ARG@ human health @ARG@ middle east respiratory syndrome ( mers ) in humans @ARG@ @ sep @ however , other coron ##aviruses still pose a continuous threat to human health , as exemplified by the recent emergence of middle east respiratory syndrome ( mers ) in humans . [SEP]

[CLS] presence of specific histopathologic lesions @ARG@ for @TRIGGER@ fh ##v - 1 @ARG@ @ sep @ a significant agreement was found between the amount of fh ##v - 1 dna determined by qpcr and the presence of specific histopathologic lesions for fh ##v - 1 but not for the other respiratory pathogens . [SEP]

[CLS] @ sep @ transient protonation of a universally conserved carboxylate on subunit c ( d6 ##1 in e . coli ) gated by the electrostatic interaction with arginine on subunit a ( r2 ##10 in e . coli ) is believed to be a crucial step in proton transfer across the membrane . [SEP]

coli @ARG@ gated @TRIGGER@ electrostatic interaction with arginine on subunit a ( r2 ##10 in e . coli ) @ARG@ @OSP@ coli @ARG@ crucial @TRIGGER@ proton transfer across the membrane @ARG@ @OSP@

[CLS] @ sep @ the purpose of this study was to assess the clinical features and ct manifestations of cov ##id - 19 by comparing patients with cov ##id - 19 pneumonia with patients with non - cov ##id - 19 pneumonia who presented at a fever observation department in shanghai , china . [SEP]

[CLS] activity of a viral ##ly encoded rna - dependent polymerase @ARG@ depend @TRIGGER@ nucleotide triphosphate ##s @ARG@ condensation @TRIGGER@ @ sep @ nevertheless , the members of nearly all rna virus families depend on the activity of a viral ##ly encoded rna - dependent polymerase for the condensation of nucleotide triphosphate ##s . [SEP]

rna virus families @ARG@ depend @TRIGGER@ viral ##ly encoded rna - dependent polymerase @ARG@ @OSP@

[CLS] effect @TRIGGER@ evaluated @TRIGGER@ immunogenicity of the recombinant mva - m @ARG@ vector @ARG@ th1 / th2 balance @ARG@ murine model @ARG@ @ sep @ the immunogenicity of the recombinant mva - m was evaluated in the murine model which revealed an effect of the vector on the th1 / th2 balance . [SEP]

[CLS] uv - inactivated sars coron ##avirus @ARG@ diagnostic tools @ARG@ prepared @TRIGGER@ vaccine @ARG@ @ sep @ in order to develop an effective vaccine and diagnostic tools , we prepared uv - inactivated sars coron ##avirus on a large scale under the strict bios ##afe ##ty level 3 ( bs ##l3 ) regulation . [SEP]

uv - inactivated sars coron ##avirus @ARG@ bios ##afe ##ty level 3 ( bs ##l3 ) @ARG@ regulation @TRIGGER@ @OSP@

gluc ##os ##uria @ARG@ gluc ##os ##uria @ARG@ @OSP@

db ##ci ##ca @ARG@ db ##ci ##ca @ARG@ @OSP@

hypoglycemic episodes @ARG@ permitted @TRIGGER@ withdrawal of the insulin therapy @ARG@ @OSP@

cattle from surface water @ARG@ reduce @TRIGGER@ waters ##hed contamination @ARG@ @OSP@

fi ##pv - specific antibodies @ARG@ protected against fi ##pv @ARG@ @OSP@

neutrophils and kill @TRIGGER@ h . som ##ni @ARG@ @OSP@

inhibit @TRIGGER@ development of an efficient immune response to the virus @ARG@ @OSP@

early administration of cid ##ofovir @ARG@ associated @TRIGGER@ lower hazard for respiratory failure development @ARG@ @OSP@

h . som ##ni cells @ARG@ caused @TRIGGER@ macrophage extracellular trap formation @ARG@ @OSP@

treatment of severe acute respiratory syndrome ( sars ) @ARG@ treatment of severe acute respiratory syndrome ( sars ) @ARG@ @OSP@

deep stromal corneal ulcers @ARG@ exud ##ative pan ##uv ##eit ##is @ARG@ @OSP@

sn ##ee ##zes @ARG@ measured @TRIGGER@ laser particle size analyse ##r @ARG@ @OSP@

therapeutic options @ARG@ tailored @TRIGGER@ patient ’ s peculiar clinical conditions @ARG@ @OSP@

double - stranded rna ( dsrna ) @ARG@ generated @TRIGGER@ intermediate during viral replication @ARG@ @OSP@

transmission of mouse hepatitis virus ( mhv ) and depend @TRIGGER@ mhv strain @ARG@ @OSP@

causes @TRIGGER@ acute encephalitis @ARG@ acute and chronic demyelinating diseases in mice @ARG@ @OSP@

porcine epidemic diarrhea virus ( ped ##v ) @ARG@ caused @TRIGGER@ economic losses to pig producers @ARG@ @OSP@

interactions between leader rna and transcriptional initiation sequences @ARG@ regulate @TRIGGER@ mhv subgen ##omic mrna transcription @ARG@ @OSP@

increase @TRIGGER@ vaccine bios ##afe ##ty @ARG@ introduced @TRIGGER@ attenuating mutations into the nsp ##1 protein @ARG@ @OSP@

r estimate estimate using using using using using using sep @ @

string - of - epitope vaccines @ARG@ for @TRIGGER@ previously unknown pathogens @ARG@ @OSP@

pathogens @ARG@ target @TRIGGER@ structural and signaling lipids @ARG@ @OSP@ structural and signaling lipids @ARG@ alter @TRIGGER@ cellular phenotype of the host cell @ARG@ @OSP@

h . som ##ni @ARG@ causes @TRIGGER@ severe bronch ##op ##neum ##onia in cattle @ARG@ @OSP@

extracellular traps @ARG@ role @TRIGGER@ host response to h . som ##ni infection in cattle @ARG@ @OSP@

kap ##osi ' s sarcoma ( ks ) @ARG@ @ARG@ @OSP@

introduce @TRIGGER@ stop codons of @ARG@ introduce @TRIGGER@ stop codons , @OSP@

induce @TRIGGER@ acute and chronic inflammatory diseases @ARG@ detrimental host response @ARG@ @OSP@

nanostructures of type i collagen films @ARG@ affect @TRIGGER@ stem colony formation @ARG@ @OSP@

bacterial communities @ARG@ derived @TRIGGER@ human skin and oral commensal ##s @ARG@ @OSP@

severe acute respiratory syndrome ( sars ) @ARG@ triggered @TRIGGER@ global alert for coron ##avirus infections @ARG@ @OSP@

human infections of sars coron ##avirus ( sars - cov ) @ARG@ @OSP@

tme ##v - based reporter constructs in transfected cells @ARG@ dependent @TRIGGER@ virus infection @ARG@ @OSP@

biod ##ef ##ense surveillance capability @ARG@ identification @TRIGGER@ new potential public health pathogens @ARG@ @OSP@

hits @ARG@ tested @TRIGGER@ hk ##u ##4 [UNK] cov and mers ##l ( pro ) inhibition @ARG@ @OSP@

formation of the viral factor ##y @ARG@ involves @TRIGGER@ complex interactions and signalling events between viral and cell factors @ARG@ @OSP@

phenyl ##sulf ##ona ##mid ##e scaffold @ARG@ mers coron ##avirus 3c ##l ( pro ) inhibitors development @ARG@ @OSP@

costimulatory pathways @ARG@ regulating @TRIGGER@ t - cell - mediated immune responses @ARG@ @OSP@

molecular dynamics simulations @ARG@ coarse - grained model @ARG@ coarse - grained model @ARG@ @OSP@ coarse - grained model @ARG@ coarse - grained model @ARG@ @OSP@

myx ##ovirus resistance protein a ( mx ##a ) @ARG@ associated @TRIGGER@ viral infections @ARG@ @OSP@

analyzed @TRIGGER@ automated dry - slide chemistry analyzer @ARG@ @OSP@

3c [UNK] like protease ( 3c ##l ( pro ) ) @ARG@ essential @TRIGGER@ viral replication @ARG@ @OSP@

para ##infl ##ue ##n ##za viruses ( hpi ##vs ) @ARG@ involved @TRIGGER@ pathogenesis of respiratory tract infections @ARG@ @OSP@

mutated variant of 8a protein @ARG@ resulting @TRIGGER@ reversion to a virulent phenotype @ARG@ @OSP@

pb ##m on a transmembrane protein @ARG@ compensate @TRIGGER@ removal of this motif from the e protein @ARG@ @OSP@

estimated @TRIGGER@ bayesian analysis @ARG@ estimated @TRIGGER@ ring trial results obtained with the different assays @ARG@ @OSP@

mhv challenge @ARG@ protective @TRIGGER@ antigenic ##ally homo ##typ ##ic and hetero ##typ ##ic strains of mhv @ARG@ @OSP@

mutating the g _ gu ##u _ u ##uu shift site @ARG@ inhibit @TRIGGER@ frameshift ##ing @ARG@ @OSP@

increase @TRIGGER@ genetic stability of the vaccine candidate @ARG@ increase @TRIGGER@ genetic stability of the vaccine candidate @ARG@ @OSP@

cytoplasmic components @ARG@ sequestered @TRIGGER@ large double [UNK] membrane vesicles called autophagosomes @ARG@ @OSP@ large double [UNK] membrane vesicles called autophagosomes @ARG@ delivered @TRIGGER@ lysosome / vacuole @ARG@ @OSP@

nsp ##4 - egfp @ARG@ colocalized @TRIGGER@ er - golgi intermediate compartment ( erg ##ic ) marker erg ##ic - 53 @ARG@ @OSP@

coron ##aviruses @ARG@ threat @TRIGGER@ human health @ARG@ @OSP@ coron ##aviruses @ARG@ threat @TRIGGER@ middle east respiratory syndrome ( mers ) in humans @ARG@ @OSP@

depend @TRIGGER@ activity of a viral ##ly encoded rna - dependent polymerase @ARG@ condensation @TRIGGER@ nucleotide triphosphate ##s @ARG@ @OSP@

diagnostic tools @ARG@ prepared @TRIGGER@ uv - inactivated sars coron ##avirus @ARG@ @OSP@

treated @TRIGGER@ systemic glucocorticoids @ARG@ @OSP@

rotavirus @ARG@ cause @TRIGGER@ infantile viral gastroenteritis @ARG@ @OSP@

temperature @ARG@ temperature @ARG@ temperature @ARG@ @OSP@

extracellular bacteria @ARG@ role @TRIGGER@ pathophysiology of ards @ARG@ @OSP@

vaccine development @ARG@ vaccine development @ARG@ @OSP@

hypoglycemic episodes @ARG@ permitted @TRIGGER@ withdrawal of the insulin therapy @ARG@ @OSP@

exacerbations of underlying copd @ARG@ cause @TRIGGER@ respiratory deterioration @ARG@ @OSP@

role @TRIGGER@ tlr3 @ARG@ protective immunity against viruses @ARG@ @OSP@

) @ARG@ leading @TRIGGER@ respiratory failure @ARG@ @OSP@

cattle from surface water @ARG@ reduce @TRIGGER@ watershed contamination @ARG@ @OSP@

vp1 / 2 gene in positive samples @ARG@ amplified @TRIGGER@ pcr @ARG@ @OSP@

respiratory tract tissues @ARG@ examined @TRIGGER@ histopathology @ARG@ @OSP@

elisa @ARG@ based @TRIGGER@ crcov antigen @ARG@ @OSP@

melting ulcers @ARG@ progressed @TRIGGER@ corneal perforation @ARG@ @OSP@

mitigate @TRIGGER@ human and financial losses @ARG@ @OSP@

fipv - specific antibodies @ARG@ protected against fipv @ARG@ @OSP@

compounds @ARG@ targeting @TRIGGER@ hiv infections @ARG@ @OSP@

neutrophils and kill @TRIGGER@ h. somni @ARG@ @OSP@

vaccine @ARG@ vaccine @ARG@ fipv 79 - 1146 challenge @ARG@ @OSP@

led @TRIGGER@ higher host interferon responses @ARG@ virus attenuation @ARG@ @OSP@

inhibit @TRIGGER@ development of an efficient immune response to the virus @ARG@ @OSP@

bovine neutrophils @ARG@ killed @TRIGGER@ h. somni @ARG@ @OSP@

early administration of cidofovir @ARG@ associated @TRIGGER@ lower hazard for respiratory failure development @ARG@ @OSP@

extracellular traps @ARG@ produced @TRIGGER@ outer membrane vesicles @ARG@ @OSP@

h. somni cells @ARG@ caused @TRIGGER@ macrophage extracellular trap formation @ARG@ @OSP@

chimeric proteins @ARG@ generated @TRIGGER@ cell culture @ARG@ @OSP@

t - cell immunity @ARG@ recovery @TRIGGER@ sars - cov infection @ARG@ @OSP@

performance @ARG@ assessed @TRIGGER@ performance @ARG@ @OSP@

treatment of severe acute respiratory syndrome ( sars ) @ARG@ treatment of severe acute respiratory syndrome ( sars ) @ARG@ @OSP@

diseases and conditions @ARG@ vaccines @ARG@ drug delivery @ARG@ @OSP@

immunohistochemistry @ARG@ immunohistochemistry @ARG@ @OSP@

sec12p @ARG@ essential @TRIGGER@ formation of transport vesicles @ARG@ @OSP@

deep stromal corneal ulcers @ARG@ exudative panuveitis @ARG@ @OSP@

pneumonia @ARG@ due @TRIGGER@ mycoplasma pneumoniae @ARG@ @OSP@

sneezes @ARG@ measured @TRIGGER@ laser particle size analyser @ARG@ @OSP@

cidofovir @ARG@ prevent @TRIGGER@ respiratory failure @ARG@ @OSP@

human vaccines @ARG@ generation @TRIGGER@ immunoglobulin responses @ARG@ @OSP@

compounds @ARG@ treatment @TRIGGER@ hiv infections @ARG@ @OSP@

therapeutic options @ARG@ tailored @TRIGGER@ patient ’ s peculiar clinical conditions @ARG@ @OSP@

double - stranded rna ( dsrna ) @ARG@ generated @TRIGGER@ intermediate during viral replication @ARG@ @OSP@

enzyme [UNK] linked immunosorbent assay @ARG@ positive @TRIGGER@ leishmaniasis @ARG@ @OSP@

transmission of mouse hepatitis virus ( mhv ) and depend @TRIGGER@ mhv strain @ARG@ @OSP@

human respiratory tract @ARG@ entry @TRIGGER@ annual deaths worldwide @ARG@ @OSP@

causes @TRIGGER@ acute encephalitis @ARG@ acute and chronic demyelinating diseases in mice @ARG@ @OSP@

porcine epidemic diarrhea virus ( pedv ) @ARG@ caused @TRIGGER@ economic losses to pig producers @ARG@ @OSP@

interactions between leader rna and transcriptional initiation sequences @ARG@ regulate @TRIGGER@ mhv subgenomic mrna transcription @ARG@ @OSP@

increase @TRIGGER@ vaccine biosafety @ARG@ introduced @TRIGGER@ attenuating mutations into the nsp1 protein @ARG@ @OSP@

r estimate estimate using using using using using using sep @ @

string - of - epitope vaccines @ARG@ for @TRIGGER@ previously unknown pathogens @ARG@ @OSP@

pathogens @ARG@ target @TRIGGER@ structural and signaling lipids @ARG@ @OSP@ structural and signaling lipids @ARG@ alter @TRIGGER@ cellular phenotype of the host cell @ARG@ @OSP@

h. somni @ARG@ causes @TRIGGER@ severe bronchopneumonia in cattle @ARG@ @OSP@

extracellular traps @ARG@ role @TRIGGER@ host response to h. somni infection in cattle @ARG@ @OSP@

formation @TRIGGER@ viral factories @ARG@ supplying @TRIGGER@ viral factories @ARG@ @OSP@

vaccination attempts @ARG@ against @TRIGGER@ fipv @ARG@ @OSP@ igg antibodies against the surface protein @ARG@ enhance @TRIGGER@ infection @ARG@ @OSP@

kaposi's sarcoma ( ks ) @ARG@ @ARG@ @OSP@

introduce @TRIGGER@ stop codons of @ARG@ introduce @TRIGGER@ stop codons, @OSP@

induce @TRIGGER@ acute and chronic inflammatory diseases @ARG@ detrimental host response @ARG@ @OSP@

assay @ARG@ based @TRIGGER@ pcr method @ARG@ @OSP@ assay @ARG@ detection @TRIGGER@ dipstick device @ARG@ @OSP@

tested @TRIGGER@ nsp1 @ARG@ for @TRIGGER@ np - 1 @ARG@ @OSP@

probe @ARG@ detect @TRIGGER@ serotype 1 ibdv strains @ARG@ @OSP@

function @ARG@ impaired @TRIGGER@ mhv - jhm infection @ARG@ @OSP@

) @ARG@ induces @TRIGGER@ fatal systemic disease @ARG@ @OSP@ ) @ARG@ mediated @TRIGGER@ inappropriate immune response @ARG@ @OSP@

membrane microdomains @ARG@ reduce @TRIGGER@ effects @ARG@ @OSP@ lipid rafts @ARG@ enhance @TRIGGER@ assembly @ARG@ @OSP@

air travel @ARG@ conduit @TRIGGER@ infectious disease spread @ARG@ @OSP@

treatment @ARG@ associated @TRIGGER@ lower 21 - day probability of respiratory failure @ARG@ @OSP@

) @ARG@ caused @TRIGGER@ novel virus @ARG@ @OSP@ ) @ARG@ caused @TRIGGER@ sars coronavirus ( sars - cov ) @ARG@ @OSP@

nanostructures of type i collagen films @ARG@ affect @TRIGGER@ stem colony formation @ARG@ @OSP@

bacterial communities @ARG@ derived @TRIGGER@ human skin and oral commensals @ARG@ @OSP@

severe acute respiratory syndrome ( sars ) @ARG@ triggered @TRIGGER@ global alert for coronavirus infections @ARG@ @OSP@

extracellular bacteria @ARG@ triggered @TRIGGER@ th17 - like innate immunity @ARG@ @OSP@ neutrophil activation @ARG@ account @TRIGGER@ etiology of ards @ARG@ @OSP@

causes @TRIGGER@ severe acute respiratory syndrome @ARG@ results @TRIGGER@ morbidity and mortality @ARG@ @OSP@

human infections of sars coronavirus ( sars - cov ) @ARG@ @OSP@

tmev - based reporter constructs in transfected cells @ARG@ dependent @TRIGGER@ virus infection @ARG@ @OSP@

biodefense surveillance capability @ARG@ identification @TRIGGER@ new potential public health pathogens @ARG@ @OSP@

hits @ARG@ tested @TRIGGER@ hku4 [UNK] cov and mersl ( pro ) inhibition @ARG@ @OSP@

formation of the viral factory @ARG@ involves @TRIGGER@ complex interactions and signalling events between viral and cell factors @ARG@ @OSP@

phenylsulfonamide scaffold @ARG@ mers coronavirus 3cl ( pro ) inhibitors development @ARG@ @OSP@

poxviral promoter @ARG@ induce @TRIGGER@ effective immune response @ARG@ @OSP@

pathogens @ARG@ target @TRIGGER@ lipids @ARG@ @OSP@ interaction maps @ARG@ allowing @TRIGGER@ visualization of differences between different types of pathogens @ARG@ @OSP@

costimulatory pathways @ARG@ regulating @TRIGGER@ t - cell - mediated immune responses @ARG@ @OSP@

hhv - 8 infection @ARG@ required @TRIGGER@ required @TRIGGER@ @OSP@

molecular methods @ARG@ evaluate @TRIGGER@ suspected respiratory tract infections @ARG@ @OSP@

scanning electron microscopy @ARG@ trapped @TRIGGER@ h. somni cells @ARG@ @OSP@ confocal microscopy @ARG@ trapped @TRIGGER@ web - like structure @ARG@ @OSP@

molecular dynamics simulations @ARG@ coarse - grained model @ARG@ coarse - grained model @ARG@ @OSP@ coarse - grained model @ARG@ coarse - grained model @ARG@ @OSP@

mediate @TRIGGER@ autophagosome formation @ARG@ @OSP@

myxovirus resistance protein a ( mxa ) @ARG@ associated @TRIGGER@ viral infections @ARG@ @OSP@

whole virion @ARG@ serves @TRIGGER@ vaccine antigen @ARG@ @OSP@ whole virion @ARG@ against @TRIGGER@ virus infection @ARG@ @OSP@

analyzed @TRIGGER@ automated dry - slide chemistry analyzer @ARG@ @OSP@

3c [UNK] like protease ( 3cl ( pro ) ) @ARG@ essential @TRIGGER@ viral replication @ARG@ @OSP@

viral pathogens @ARG@ viral pathogens @ARG@ hpv @ARG@ @OSP@ hpv @ARG@ hemorrhagic fever viruses @ARG@ @OSP@

sars - cov - [UNK] e protein 8a @ARG@ mutated @TRIGGER@ pbm @ARG@ @OSP@

parainfluenza viruses ( hpivs ) @ARG@ involved @TRIGGER@ pathogenesis of respiratory tract infections @ARG@ @OSP@

mutated variant of 8a protein @ARG@ resulting @TRIGGER@ reversion to a virulent phenotype @ARG@ @OSP@

increase @TRIGGER@ dlat @ARG@ increase @TRIGGER@ dlat @ARG@ @OSP@

pbm on a transmembrane protein @ARG@ compensate @TRIGGER@ removal of this motif from the e protein @ARG@ @OSP@

estimated @TRIGGER@ bayesian analysis @ARG@ estimated @TRIGGER@ ring trial results obtained with the different assays @ARG@ @OSP@

mhv challenge @ARG@ protective @TRIGGER@ antigenically homotypic and heterotypic strains of mhv @ARG@ @OSP@

bovine neutrophils and macrophages @ARG@ produce @TRIGGER@ extracellular traps @ARG@ @OSP@

antiviral vaccine @ARG@ developing @TRIGGER@ therapeutic viruses @ARG@ @OSP@ therapeutic viruses @ARG@ penetrate @TRIGGER@ hard - to - reach organs @ARG@ @OSP@

mutating the g _ guu _ uuu shift site @ARG@ inhibit @TRIGGER@ frameshifting @ARG@ @OSP@

role @TRIGGER@ physiological processes @ARG@ @OSP@ induced @TRIGGER@ pathological situations @ARG@ @OSP@

pathogens @ARG@ subvert @TRIGGER@ autophagy @ARG@ @OSP@

increase @TRIGGER@ genetic stability of the vaccine candidate @ARG@ increase @TRIGGER@ genetic stability of the vaccine candidate @ARG@ @OSP@

technical indicators @ARG@ against @TRIGGER@ gas - tight chemical protective clothing @ARG@ @OSP@ ventilated protective clothing @ARG@ against @TRIGGER@ particulate radioactive contamination @ARG@ @OSP@

hku4 [UNK] cov 3cl ( pro ) @ARG@ @ARG@ @OSP@

e3 region @ARG@ e3 region @ARG@ e3 - cr1γ @ARG@ @OSP@

cytoplasmic components @ARG@ sequestered @TRIGGER@ large double [UNK] membrane vesicles called autophagosomes @ARG@ @OSP@ large double [UNK] membrane vesicles called autophagosomes @ARG@ delivered @TRIGGER@ lysosome / vacuole @ARG@ @OSP@

nsp4 - egfp @ARG@ colocalized @TRIGGER@ er - golgi intermediate compartment ( ergic ) marker ergic - 53 @ARG@ @OSP@

highlights @ARG@ mers [UNK] cov @ARG@ 3cl ( pro ) @ARG@ @OSP@

pharmacological inhibitor of phosphodiesterase 5 ( pde5 ) @ARG@ result @TRIGGER@ cardiovascular protection @ARG@ @OSP@

coronaviruses @ARG@ threat @TRIGGER@ human health @ARG@ @OSP@ coronaviruses @ARG@ threat @TRIGGER@ middle east respiratory syndrome ( mers ) in humans @ARG@ @OSP@

presence of specific histopathologic lesions @ARG@ for @TRIGGER@ fhv - 1 @ARG@ @OSP@

depend @TRIGGER@ activity of a virally encoded rna - dependent polymerase @ARG@ condensation @TRIGGER@ nucleotide triphosphates @ARG@ @OSP@

immunogenicity of the recombinant mva - m @ARG@ evaluated @TRIGGER@ murine model @ARG@ @OSP@ immunogenicity of the recombinant mva - m @ARG@ effect @TRIGGER@ th1 / th2 balance @ARG@ @OSP@

diagnostic tools @ARG@ prepared @TRIGGER@ uv - inactivated sars coronavirus @ARG@ @OSP@

polymerase chain reaction @ARG@ on @TRIGGER@ bone marrow @ARG@ @OSP@

serum @ARG@ frozen @TRIGGER@ analysis at a later date @ARG@ @OSP@ serum @ARG@ banked @TRIGGER@ analysis at a later date @ARG@ @OSP@

sepsis @ARG@ causes @TRIGGER@ ards @ARG@ @OSP@

diabetes mellitus @ARG@ treatment @TRIGGER@ long ‐ acting insulin @ARG@ @OSP@

algorithm @ARG@ allowed @TRIGGER@ physician override @ARG@ @OSP@

urinalysis @ARG@ revealed @TRIGGER@ glucosuria without ketonuria @ARG@ @OSP@

dbcica @ARG@ modeling @TRIGGER@ hit identification @ARG@ @OSP@

cat @ARG@ treated @TRIGGER@ systemic glucocorticoids @ARG@ @OSP@

rotavirus @ARG@ cause @TRIGGER@ infantile viral gastroenteritis @ARG@ @OSP@

storage time @ARG@ designing @TRIGGER@ retrospective study @ARG@ @OSP@ temperature @ARG@ designing @TRIGGER@ retrospective study @ARG@ @OSP@

cells @ARG@ roles @TRIGGER@ lung fibrosis @ARG@ @OSP@

extracellular bacteria @ARG@ role @TRIGGER@ pathophysiology of ards @ARG@ @OSP@

vaccine development @ARG@ hampered @TRIGGER@ inherent instability of the virus @ARG@ @OSP@ drug discovery @ARG@ hampered @TRIGGER@ inherent instability of the virus @ARG@ @OSP@

hypoglycemic episodes @ARG@ permitted @TRIGGER@ withdrawal of the insulin therapy @ARG@ @OSP@

acute exacerbations of underlying copd @ARG@ cause @TRIGGER@ respiratory deterioration @ARG@ @OSP@

histologic or antigenic detection of fhv - 1 @ARG@ by @TRIGGER@ qpcr @ARG@ @OSP@

tlr3 @ARG@ protective @TRIGGER@ immunity against viruses @ARG@ @OSP@

) @ARG@ leading @TRIGGER@ respiratory failure @ARG@ @OSP@ ) @ARG@ leading @TRIGGER@ mortality @ARG@ @OSP@

restricting cattle from surface water @ARG@ reduce @TRIGGER@ watershed contamination @ARG@ @OSP@

vp1 / 2 gene @ARG@ amplified @TRIGGER@ pcr @ARG@ @OSP@

necropsy @ARG@ performed @TRIGGER@ cats @ARG@ @OSP@ respiratory tract tissues @ARG@ examined @TRIGGER@ histopathology @ARG@ @OSP@

elisa @ARG@ based @TRIGGER@ crcov antigen @ARG@ @OSP@ elisa @ARG@ based @TRIGGER@ immunofluorescence assay @ARG@ @OSP@

melting ulcers @ARG@ progressed @TRIGGER@ corneal perforation @ARG@ @OSP@

human and financial losses @ARG@ result @TRIGGER@ future global pandemics @ARG@ @OSP@

antibodies @ARG@ after @TRIGGER@ immunization @ARG@ @OSP@

intracellular organisms compatible with amastigotes of the genus leishmania @ARG@ located @TRIGGER@ uveal tract @ARG@ @OSP@ intracellular organisms compatible with amastigotes of the genus leishmania @ARG@ located @TRIGGER@ cornea @ARG@ @OSP@ intracellular organisms compatible with amastigotes of the genus leishmania @ARG@ located @TRIGGER@ sclera @ARG@ @OSP@ intracellular organisms compatible with amastigotes of the genus leishmania @ARG@ located @TRIGGER@ retina @ARG@ @OSP@

compounds @ARG@ targeting @TRIGGER@ hiv infections @ARG@ @OSP@

bovine neutrophils @ARG@ phagocytose @TRIGGER@ h. somni @ARG@ @OSP@ macrophages @ARG@ phagocytose @TRIGGER@ h. somni @ARG@ @OSP@ bovine neutrophils @ARG@ kill @TRIGGER@ h. somni @ARG@ @OSP@ macrophages @ARG@ kill @TRIGGER@ h. somni @ARG@ @OSP@

the vaccine @ARG@ tested @TRIGGER@ cats @ARG@ @OSP@

deletions in the carboxy - terminal region of nsp1 protein @ARG@ led @TRIGGER@ higher host interferon responses and virus attenuation @ARG@ @OSP@

preferential infection of mature dcs @ARG@ inhibit @TRIGGER@ development of an efficient immune response @ARG@ @OSP@

bovine neutrophils @ARG@ killed @TRIGGER@ h. somni @ARG@ @OSP@ bovine neutrophils @ARG@ trapped @TRIGGER@ h. somni @ARG@ @OSP@

early administration of cidofovir @ARG@ associated @TRIGGER@ lower hazard for respiratory failure development @ARG@ @OSP@

traps @ARG@ produced @TRIGGER@ outer membrane vesicles @ARG@ @OSP@

macrophages @ARG@ with @TRIGGER@ h. somni cells @ARG@ @OSP@ macrophages @ARG@ caused @TRIGGER@ macrophage extracellular trap formation @ARG@ @OSP@

chimeric proteins generated in cell culture @ARG@ increased @TRIGGER@ virus fitness @ARG@ @OSP@

t - cell immunity @ARG@ role @TRIGGER@ recovery from sars - cov infection @ARG@ @OSP@

performance @ARG@ assessed @TRIGGER@ 103 rnas from suspected cases @ARG@ @OSP@ 103 rnas from suspected cases @ARG@ analyzed @TRIGGER@ real - time pcr technique @ARG@ @OSP@

treatment @TRIGGER@ severe acute respiratory syndrome ( sars ) @ARG@ ribavirin - steroid therapy @ARG@ @OSP@

peptides @ARG@ towards @TRIGGER@ vaccines @ARG@ @OSP@ peptides @ARG@ towards @TRIGGER@ drug delivery @ARG@ @OSP@

pigs @ARG@ infected @TRIGGER@ prrsv @ARG@ @OSP@

sec12p @ARG@ essential @TRIGGER@ formation of transport vesicles @ARG@ @OSP@

ophthalmic examination @ARG@ revealed @TRIGGER@ bilateral deep stromal corneal ulcers @ARG@ @OSP@ ophthalmic examination @ARG@ revealed @TRIGGER@ exudative panuveitis @ARG@ @OSP@ ophthalmic examination @ARG@ revealed @TRIGGER@ secondary glaucoma @ARG@ @OSP@

pneumonia @ARG@ due @TRIGGER@ mycoplasma pneumoniae @ARG@ @OSP@

sneezes @ARG@ measured @TRIGGER@ laser particle size analyser @ARG@ @OSP@

cidofovir be administered within 7 days from symptom onset @ARG@ prevent @TRIGGER@ respiratory failure in patients with potentially severe hadv pneumonia @ARG@ @OSP@

human vaccines @ARG@ protection @TRIGGER@ infectious pathogens @ARG@ @OSP@ human vaccines @ARG@ generation @TRIGGER@ specific immunoglobulin responses @ARG@ @OSP@

compounds @ARG@ use @TRIGGER@ antiviral drugs @ARG@ @OSP@ compounds @ARG@ treatment @TRIGGER@ hiv infections @ARG@ @OSP@

therapeutic options @ARG@ tailored @TRIGGER@ patient ’ s peculiar clinical conditions @ARG@ @OSP@

double - stranded rna ( dsrna ) @ARG@ generated @TRIGGER@ viral replication @ARG@ @OSP@

leishmaniasis @ARG@ treatment @TRIGGER@ allopurinol @ARG@ @OSP@

) @ARG@ depend @TRIGGER@ mhv strain @ARG@ @OSP@ ) @ARG@ depend @TRIGGER@ host genotype @ARG@ @OSP@

human respiratory tract @ARG@ entry @TRIGGER@ viruses @ARG@ @OSP@

) @ARG@ causes @TRIGGER@ acute and chronic demyelinating diseases @ARG@ @OSP@ ) @ARG@ causes @TRIGGER@ acute encephalitis @ARG@ @OSP@

porcine epidemic diarrhea virus ( pedv ) @ARG@ caused @TRIGGER@ economic losses to pig producers @ARG@ @OSP@

interactions between leader rna and transcriptional initiation sequences @ARG@ regulate @TRIGGER@ mhv subgenomic mrna transcription @ARG@ @OSP@

increase @TRIGGER@ vaccine biosafety @ARG@ attenuating mutations into the nsp1 protein @ARG@ @OSP@

estimate r @ARG@ using @TRIGGER@ daily case notifications @ARG@ @OSP@

string - of - epitope vaccines @ARG@ for @TRIGGER@ previously unknown pathogens @ARG@ @OSP@

bacterial and viral pathogens @ARG@ target @TRIGGER@ predominantly structural and signaling lipids @ARG@ @OSP@ bacterial and viral pathogens @ARG@ alter @TRIGGER@ cellular phenotype of the host cell @ARG@ @OSP@

h. somni @ARG@ causes @TRIGGER@ severe bronchopneumonia in cattle @ARG@ @OSP@

extracellular traps @ARG@ role @TRIGGER@ host response to h. somni infection in cattle @ARG@ @OSP@

mitochondria @ARG@ participate @TRIGGER@ formation of viral factories @ARG@ @OSP@ cytoplasmic membranes @ARG@ participate @TRIGGER@ formation of viral factories @ARG@ @OSP@ cytoskeletal components @ARG@ participate @TRIGGER@ formation of viral factories @ARG@ @OSP@

vaccination @ARG@ against @TRIGGER@ fipv @ARG@ @OSP@ igg antibodies @ARG@ against @TRIGGER@ surface protein @ARG@ @OSP@

multifactorial pathogenesis @ARG@ hinged @TRIGGER@ immune dysfunction @ARG@ @OSP@ kaposi's sarcoma ( ks ) @ARG@ hinged @TRIGGER@ immune dysfunction @ARG@ @OSP@

vitro @ARG@ used @TRIGGER@ introduce stop codons in the genomic dna of the alpha and beta chains of the murine class ii major histocompatibility complex antigen @ARG@ @OSP@

infections @ARG@ induce @TRIGGER@ acute and chronic inflammatory diseases @ARG@ @OSP@ contribution @TRIGGER@ innate immune response @ARG@ detrimental host response @ARG@ @OSP@

severe hadv pneumonia @ARG@ risk @TRIGGER@ respiratory failure @ARG@ @OSP@

pcr method coupled to detection of pcr products @ARG@ by @TRIGGER@ dipstick device @ARG@ @OSP@ the assay @ARG@ based @TRIGGER@ pcr method coupled to detection of pcr products @ARG@ @OSP@

samples @ARG@ tested @TRIGGER@ qpcr @ARG@ @OSP@

probe @ARG@ detect @TRIGGER@ serotype 1 ibdv strains @ARG@ @OSP@ probe @ARG@ detect @TRIGGER@ serotype 2 ibdv strain @ARG@ @OSP@

function @ARG@ impaired @TRIGGER@ mhv - jhm infection @ARG@ @OSP@ mhv - jhm infection @ARG@ decreased @TRIGGER@ stimulation of cd8 t cells @ARG@ @OSP@

feline infectious peritonitis virus ( fipv ) @ARG@ induces @TRIGGER@ fatal systemic disease @ARG@ @OSP@ fatal systemic disease @ARG@ mediated @TRIGGER@ inappropriate immune response @ARG@ @OSP@

membrane microdomains @ARG@ reduce @TRIGGER@ these effects @ARG@ @OSP@ lipid rafts @ARG@ reduce @TRIGGER@ these effects @ARG@ @OSP@ membrane microdomains @ARG@ enhance @TRIGGER@ assembly @ARG@ @OSP@

air travel @ARG@ conduit @TRIGGER@ infectious disease spread @ARG@ @OSP@

treatment @ARG@ associated @TRIGGER@ lower 21 - day probability of respiratory failure @ARG@ @OSP@

) @ARG@ caused @TRIGGER@ sars coronavirus ( sars - cov ) @ARG@ @OSP@

the nanostructures of type i collagen films @ARG@ affect @TRIGGER@ stem colony formation through the collagen – stroma interactions @ARG@ @OSP@

bacterial communities @ARG@ derived @TRIGGER@ human skin @ARG@ @OSP@ bacterial communities @ARG@ derived @TRIGGER@ oral commensals @ARG@ @OSP@ bacterial communities @ARG@ derived @TRIGGER@ environmental generalist bacteria @ARG@ @OSP@

severe acute respiratory syndrome ( sars ) @ARG@ triggered @TRIGGER@ global alert for coronavirus infections @ARG@ @OSP@

extracellular bacteria @ARG@ triggered @TRIGGER@ th17 - like innate immunity with neutrophil activation @ARG@ @OSP@ extracellular bacteria @ARG@ accounts @TRIGGER@ etiology of ards @ARG@ @OSP@

covid - 19 @ARG@ causes @TRIGGER@ severe acute respiratory syndrome @ARG@ @OSP@ covid - 19 @ARG@ results @TRIGGER@ mortality @ARG@ @OSP@ covid - 19 @ARG@ results @TRIGGER@ morbidity @ARG@ @OSP@

humans @ARG@ halted @TRIGGER@ public health measures @ARG@ @OSP@

frameshifting @ARG@ dependent @TRIGGER@ virus infection @ARG@ @OSP@ tmev @ARG@ based @TRIGGER@ reporter constructs in transfected cells @ARG@ @OSP@

increased awareness @ARG@ fostered @TRIGGER@ rapid identification of new potential public health pathogens @ARG@ @OSP@ new tools @ARG@ fostered @TRIGGER@ rapid identification of new potential public health pathogens @ARG@ @OSP@

the identified hits @ARG@ tested @TRIGGER@ hku4 ‐ cov and mers ‐ cov 3cl ( pro ) inhibition @ARG@ @OSP@

formation of the viral factory @ARG@ involves @TRIGGER@ interactions and signalling events between viral and cell factors @ARG@ @OSP@

phenylsulfonamide scaffold @ARG@ mers coronavirus 3cl ( pro ) inhibitors @ARG@ development @TRIGGER@ @OSP@

poxviral promoter @ARG@ induce @TRIGGER@ immune response against fipv @ARG@ @OSP@

interaction maps @ARG@ visualization @TRIGGER@ differences between different types of pathogens @ARG@ @OSP@ pathogens @ARG@ target @TRIGGER@ lipids @ARG@ @OSP@

costimulatory pathways @ARG@ regulating @TRIGGER@ t - cell - mediated immune responses @ARG@ @OSP@

development of ks @ARG@ genetic @ARG@ required @TRIGGER@ @OSP@ development of ks @ARG@ environmental @ARG@ required @TRIGGER@ @OSP@ development of ks @ARG@ immunologic @ARG@ required @TRIGGER@ @OSP@

diagnostic panels @ARG@ evaluate @TRIGGER@ suspected respiratory tract infections @ARG@ @OSP@

confocal microscopy @ARG@ observed @TRIGGER@ h. somni cells trapped within a web - like structure @ARG@ @OSP@ scanning electron microscopy @ARG@ observed @TRIGGER@ h. somni cells trapped within a web - like structure @ARG@ @OSP@

virus @ARG@ assembly @TRIGGER@ fluctuating lipid membrane @ARG@ @OSP@

atg proteins @ARG@ mediate @TRIGGER@ it @ARG@ @OSP@ autophagy @ARG@ atg proteins @ARG@ mediate @TRIGGER@ @OSP@

) @ARG@ associated @TRIGGER@ bacterial and viral infections @ARG@ @OSP@ myxovirus resistance protein a ( mxa ) @ARG@ associated @TRIGGER@ bacterial and viral infections @ARG@ @OSP@

analyzed @ARG@ using @TRIGGER@ automated dry - slide chemistry analyzer @ARG@ @OSP@

3c ‐ like protease ( 3cl ( pro ) ) @ARG@ target @TRIGGER@ antiviral drug development @ARG@ @OSP@

hemorrhagic fever viruses @ARG@ need @TRIGGER@ antiviral therapies @ARG@ @OSP@ hcv @ARG@ need @TRIGGER@ antiviral therapies @ARG@ @OSP@ hpv @ARG@ need @TRIGGER@ antiviral therapies @ARG@ @OSP@ viral pathogens @ARG@ need @TRIGGER@ antiviral therapies @ARG@ @OSP@

sars - cov - ∆e protein 8a mutated @ARG@ regained @TRIGGER@ virulence @ARG@ @OSP@

human parainfluenza viruses ( hpivs ) @ARG@ involved @TRIGGER@ pathogenesis of respiratory tract infections @ARG@ @OSP@

the virus @ARG@ incorporated @TRIGGER@ mutated variant of 8a protein @ARG@ @OSP@ sars - cov - ∆e @ARG@ incorporated @TRIGGER@ mutated variant of 8a protein @ARG@ @OSP@

chains @ARG@ increase @TRIGGER@ dlat @ARG@ @OSP@

the virus @ARG@ requires @TRIGGER@ pbm on a transmembrane protein @ARG@ @OSP@

sensitivity and specificity of each assay @ARG@ estimated @TRIGGER@ bayesian analysis @ARG@ @OSP@ bayesian analysis @ARG@ applied @TRIGGER@ ring trial results obtained with the different assays @ARG@ @OSP@

immunity to mhv challenge @ARG@ protective @TRIGGER@ against both antigenically homotypic and heterotypic strains of mhv @ARG@ @OSP@

macrophages @ARG@ produce @TRIGGER@ extracellular traps @ARG@ @OSP@ bovine neutrophils @ARG@ produce @TRIGGER@ extracellular traps @ARG@ @OSP@

therapeutic viruses @ARG@ penetrate @TRIGGER@ hard - to - reach organs @ARG@ @OSP@

site @ARG@ inhibit @TRIGGER@ frameshifting @ARG@ @OSP@ site @ARG@ results @TRIGGER@ attenuated virus with reduced growth kinetics and a small - plaque phenotype @ARG@ @OSP@

this pathway @ARG@ eliminate @TRIGGER@ unwanted structures @ARG@ @OSP@

pathogens @ARG@ subvert @TRIGGER@ autophagy @ARG@ @OSP@

increase @TRIGGER@ genetic stability of the vaccine candidate @ARG@ small attenuating deletions in e gene @ARG@ @OSP@ small attenuating deletions in e gene @ARG@ preventing @TRIGGER@ incorporation of novel chimeric proteins in the virus genome @ARG@ @OSP@

gas - tight chemical protective clothing @ARG@ against @TRIGGER@ particulate radioactive contamination @ARG@ @OSP@ ventilated protective clothing @ARG@ against @TRIGGER@ particulate radioactive contamination @ARG@ @OSP@

) @ARG@ represents @TRIGGER@ surrogate model for anti ‐ mers drug discovery @ARG@ @OSP@

e3 region of all simian and human types classified within species human mastadenovirus b ( hadv - b ) @ARG@ encodes @TRIGGER@ highly conserved orfs @ARG@ @OSP@ e3 region of all simian and human types classified within species human mastadenovirus b ( hadv - b ) @ARG@ encodes @TRIGGER@ e3 - cr1β @ARG@ @OSP@ e3 region of all simian and human types classified within species human mastadenovirus b ( hadv - b ) @ARG@ encodes @TRIGGER@ e3 - cr1γ @ARG@ @OSP@

cytoplasmic components @ARG@ sequestered @TRIGGER@ double ‐ membrane vesicles @ARG@ @OSP@ cytoplasmic components @ARG@ sequestered @TRIGGER@ autophagosomes @ARG@ @OSP@ cytoplasmic components @ARG@ delivered @TRIGGER@ lysosome / vacuole @ARG@ @OSP@

nsp4 - egfp @ARG@ colocalized @TRIGGER@ er - golgi intermediate compartment ( ergic ) marker ergic - 53 @ARG@ @OSP@

3cl ( pro ) @ARG@ target @TRIGGER@ coronavirus infection @ARG@ @OSP@ mers ‐ cov @ARG@ related @TRIGGER@ bat hku4 ‐ cov. @ARG@ @OSP@

inhibitor @TRIGGER@ phosphodiesterase 5 ( pde5 ) @ARG@ sildenafil @ARG@ @OSP@

coronaviruses @ARG@ pose @TRIGGER@ threat to human health @ARG@ @OSP@

amount of fhv - 1 dna @ARG@ determined @TRIGGER@ qpcr @ARG@ @OSP@

coli @ARG@ gated @TRIGGER@ electrostatic interaction with arginine on subunit a ( r210 in e. coli ) @ARG@ @OSP@ coli @ARG@ crucial @TRIGGER@ proton transfer across the membrane @ARG@ @OSP@

assess @TRIGGER@ ct manifestations @ARG@ covid - 19 @ARG@ @OSP@ assess @TRIGGER@ clinical features @ARG@ covid - 19 @ARG@ @OSP@

rna virus families @ARG@ depend @TRIGGER@ virally encoded rna - dependent polymerase @ARG@ @OSP@

recombinant mva - m @ARG@ effect @TRIGGER@ th1 / th2 balance @ARG@ @OSP@

uv - inactivated sars coronavirus @ARG@ biosafety level 3 ( bsl3 ) @ARG@ regulation @TRIGGER@ @OSP@