[CLS] col ##ostr ##um @ARG@ absorption through 2 weeks of age @ARG@ capable @TRIGGER@ transferred @TRIGGER@ pups @ARG@ antibody @ARG@ @ sep @ cross - foster ##ing experiments showed that antibody was transferred via col ##ostr ##um and not in utero , and that pups were capable of absorption through 2 weeks of age . [SEP]

[CLS] public education campaign @ARG@ prevent @TRIGGER@ educ ##ate @TRIGGER@ singapore ##ans @ARG@ sars @ARG@ spread of the disease @ARG@ @ sep @ about a month into the epidemic , a public education campaign was mounted to educ ##ate singapore ##ans on sars and adoption of appropriate behaviours to prevent the spread of the disease . [SEP]

public education campaign @ARG@ educ ##ate @TRIGGER@ singapore ##ans on sars and adoption of appropriate behaviours to prevent the spread of the disease @ARG@ @OSP@

[CLS] in vitro validation on the mers [UNK] cov 3c ##l ( pro ) @ARG@ supported @TRIGGER@ pharmac ##ophore modeling study @ARG@ @ sep @ to the best of our knowledge , this is the first pharmac ##ophore modeling study supported by in vitro validation on the mers ‐ cov 3c ##l ( pro ) . [SEP]

pharmac ##ophore modeling study @ARG@ supported @TRIGGER@ in vitro validation @ARG@ @OSP@

[CLS] 3d queries @ARG@ screen @TRIGGER@ used @TRIGGER@ national cancer institute database @ARG@ novel nonp ##eptid ##om ##imetic 3c ##l ( pro ) inhibitors @ARG@ @ sep @ the best models were used as 3d queries to screen the national cancer institute database for novel nonp ##eptid ##om ##imetic 3c ##l ( pro ) inhibitors . [SEP]

[CLS] enable @TRIGGER@ intersp ##ec ##ies transmission of the various virus gene segments @ARG@ @ sep @ here , we provide an overview of the ecology and evolutionary adaptations of iav ##s , with a focus on a review of the molecular factors that enable intersp ##ec ##ies transmission of the various virus gene segments . [SEP]

molecular factors @ARG@ enable @TRIGGER@ intersp ##ec ##ies transmission of the various virus gene segments @ARG@ @OSP@

[CLS] immunological adjuvants @ARG@ enhance @TRIGGER@ pox ##virus - based cd8 ( + ) t - cell vaccines @ARG@ @ sep @ in this review , we highlight these new findings with a particular emphasis on their potential as immunological adjuvants to enhance pox ##virus - based cd8 ( + ) t - cell vaccines . [SEP]

immunological adjuvants @ARG@ enhance @TRIGGER@ pox ##virus - based cd8 ( + ) t - cell vaccines @ARG@ @OSP@

[CLS] ari @ARG@ role @TRIGGER@ supports @TRIGGER@ this virus @ARG@ hbo ##v - 1 @ARG@ related @TRIGGER@ @ sep @ the sole identification of hbo ##v - 1 supports the hypothesis that this particular genotype is strongly related to ari , and contributes to the role of this virus in the aetiology of respiratory diseases . [SEP]

[CLS] complete assembly @ARG@ membrane @ARG@ thermodynamic and kinetic effects @ARG@ dimensional reduction @ARG@ association of adsorbed subunits @ARG@ promote @TRIGGER@ inhibit @TRIGGER@ @ sep @ our simulations show that the membrane can promote association of adsorbed subunits through dimensional reduction , but it also introduces thermodynamic and kinetic effects that can inhibit complete assembly . [SEP]

[CLS] sars - cov transmission @ARG@ role @TRIGGER@ sars - cov - like viruses @ARG@ civ ##ets @ARG@ @ sep @ the discovery of sars - cov - like viruses in masked palm civ ##ets ( pag ##uma larva ##ta ) raises the possibility that civ ##ets play a role in sars - cov transmission . [SEP]

civ ##ets @ARG@ role @TRIGGER@ sars - cov transmission @ARG@ @OSP@ masked palm civ ##ets ( pag ##uma larva ##ta ) @ARG@ role @TRIGGER@ sars - cov transmission @ARG@ @OSP@

[CLS] validated @TRIGGER@ 1 , 280 compounds identified as potentially active trigger * against * trigger arg * rsv ( long strain ) @ARG@ assay @ARG@ against @TRIGGER@ @ sep @ the assay was validated with 1 , 280 compounds identified as potentially active against rsv ( long strain ) in a virus - based screen . [SEP]

[CLS] importance of these macro ##dom ##ains @ARG@ activity of the sars - cov rt ##c @ARG@ reverse genetic approach @ARG@ assess @TRIGGER@ @ sep @ here , we describe the application of a reverse genetic approach to assess the importance of these macro ##dom ##ains for the activity of the sars - cov rt ##c . [SEP]

reverse genetic approach @ARG@ assess @TRIGGER@ importance of these macro ##dom ##ains for the activity of the sars - cov rt ##c @ARG@ @OSP@

[CLS] mers [UNK] cov 3c ##l ( pro ) enzyme inhibitors @ARG@ hk ##u ##4 [UNK] cov 3c ##l ( pro ) @ARG@ identification @TRIGGER@ @ sep @ hk ##u ##4 ‐ cov 3c ##l ( pro ) is a useful surrogate model for the identification of mers ‐ cov 3c ##l ( pro ) enzyme inhibitors . [SEP]

hk ##u ##4 ‐ cov 3c ##l ( pro ) @ARG@ identification @TRIGGER@ mers ‐ cov 3c ##l ( pro ) enzyme inhibitors @ARG@ @OSP@

[CLS] multiv ##alent interactions of glycans with their cognate proteins @ARG@ mediated @TRIGGER@ roles @ARG@ gb ##ps @ARG@ lectins @ARG@ glycan - binding proteins @ARG@ @ sep @ these roles are mediated by specific multiv ##alent interactions of glycans with their cognate proteins ( generally termed as glycan - binding proteins or gb ##ps or lectins ) . [SEP]

[CLS] hist ##ophilus som ##ni @ARG@ causes @TRIGGER@ respiratory , reproductive , cardiac and neuronal diseases in cattle @ARG@ @ sep @ abstract hist ##ophilus som ##ni ( formerly haem ##ophilus som ##n ##us ) is a gram - negative ple ##omorphic cocc ##obac ##illus that causes respiratory , reproductive , cardiac and neuronal diseases in cattle . [SEP]

hist ##ophilus som ##ni @ARG@ causes @TRIGGER@ respiratory , reproductive , cardiac and neuronal diseases in cattle @ARG@ @OSP@ haem ##ophilus som ##n ##us @ARG@ causes @TRIGGER@ respiratory , reproductive , cardiac and neuronal diseases in cattle @ARG@ @OSP@ gram - negative ple ##omorphic cocc ##obac ##illus @ARG@ causes @TRIGGER@ respiratory , reproductive , cardiac and neuronal diseases in cattle @ARG@ @OSP@

[CLS] elisa @ARG@ identified @TRIGGER@ seropositive dogs @ARG@ test @TRIGGER@ presence of antibodies to crc ##ov in canine serum samples @ARG@ @ sep @ an elisa , used to test for the presence of antibodies to crc ##ov in canine serum samples , identified seropositive dogs in uk , usa , canada , republic of ireland and greece . [SEP]

elisa @ARG@ identified @TRIGGER@ seropositive dogs @ARG@ @OSP@ elisa @ARG@ test @TRIGGER@ presence of antibodies to crc ##ov in canine serum samples @ARG@ @OSP@

[CLS] lipid species @ARG@ host – pathogen interactions @ARG@ generation @TRIGGER@ role @TRIGGER@ interplay @TRIGGER@ novel therapeutic drugs @ARG@ @ sep @ a better understanding of the interplay between host – pathogen interactions will not only help elucidate the fundamental role of lipid species in cellular physiology , but will also aid in the generation of novel therapeutic drugs . [SEP]

[CLS] 2009 influenza a h1n1 virus @ARG@ oligo ##ch ##rom ##ato ##graphic assay @ARG@ detection @TRIGGER@ speed - oligo novel influenza a h1n1 @ARG@ @ sep @ a new oligo ##ch ##rom ##ato ##graphic assay , speed - oligo novel influenza a h1n1 , was designed and optimized for the specific detection of the 2009 influenza a h1n1 virus . [SEP]

[CLS] component @TRIGGER@ viral replication / transcription complex ( rt ##c ) @ARG@ multi - domain non - structural protein 3 of sars - coron ##avirus @ARG@ @ sep @ abstract the multi - domain non - structural protein 3 of sars - coron ##avirus is a component of the viral replication / transcription complex ( rt ##c ) . [SEP]

multi - domain non - structural protein 3 of sars - coron ##avirus @ARG@ component @TRIGGER@ viral replication / transcription complex ( rt ##c ) @ARG@ @OSP@

[CLS] autophag ##osomal marker lc3 @ARG@ dependent @TRIGGER@ appearance of vesicular nsp ##4 - egfp @ARG@ vesicular nsp ##4 - egfp @ARG@ intracellular calcium levels @ARG@ colocalized @TRIGGER@ @ sep @ the appearance of vesicular nsp ##4 - egfp was dependent on intracellular calcium levels , and vesicular nsp ##4 - egfp colocalized with the autophag ##osomal marker lc3 . [SEP]

[CLS] diagnostic real - time pcr results @ARG@ correlate @TRIGGER@ histopathologic lesions in cats with clinical signs of upper respiratory infection ( ur ##i ) @ARG@ @ sep @ this is a descriptive study designed to correlate diagnostic real - time pcr results with histopathologic lesions in cats with clinical signs of upper respiratory infection ( ur ##i ) . [SEP]

correlate @TRIGGER@ diagnostic real - time pcr results @ARG@ histopathologic lesions in cats with clinical signs of upper respiratory infection ( ur ##i ) @ARG@ @OSP@

[CLS] select @TRIGGER@ protein model @ARG@ quality of available experimental structures @ARG@ evaluate @TRIGGER@ validation tools @ARG@ @ sep @ moreover , availability of accurate and efficient validation tools would help molecular biologists and computational chem ##ists to evaluate quality of available experimental structures and to select a protein model which is the most suitable for a given scientific problem . [SEP]

accurate and efficient validation tools @ARG@ evaluate @TRIGGER@ quality of available experimental structures @ARG@ @OSP@ molecular biologists @ARG@ evaluate @TRIGGER@ quality of available experimental structures @ARG@ @OSP@ computational chem ##ists @ARG@ evaluate @TRIGGER@ quality of available experimental structures @ARG@ @OSP@ accurate and efficient validation tools @ARG@ select @TRIGGER@ protein model which is the most suitable @ARG@ @OSP@ molecular biologists @ARG@ select @TRIGGER@ protein model which is the most suitable @ARG@ @OSP@ computational chem ##ists @ARG@ select @TRIGGER@ protein model which is the most suitable @ARG@ @OSP@

[CLS] system dynamics @ARG@ association @ARG@ membrane deformation @ARG@ protein diffusion @ARG@ adsorption onto the membrane @ARG@ assembly and budding @ARG@ depend @TRIGGER@ @ sep @ furthermore , the simulations demonstrate that assembly and budding depend crucially on the system dynamics via multiple timescale ##s related to membrane deformation , protein diffusion , association , and adsorption onto the membrane . [SEP]

assembly and budding @ARG@ depend @TRIGGER@ system dynamics @ARG@ @OSP@ assembly and budding @ARG@ via @TRIGGER@ multiple timescale ##s related to membrane deformation @ARG@ @OSP@ assembly and budding @ARG@ via @TRIGGER@ protein diffusion , association , and adsorption onto the membrane @ARG@ @OSP@

[CLS] microc ##ep ##hal ##ly in the babies of mothers infected during pregnancy @ARG@ zikv @ARG@ causes @TRIGGER@ @ sep @ however , during the 2015 – 2016 epidemic in central and south america , when millions of people were infected , it was discovered that zikv causes microc ##ep ##hal ##y in the babies of mothers infected during pregnancy . [SEP]

zikv @ARG@ causes @TRIGGER@ microc ##ep ##hal ##y in the babies of mothers infected during pregnancy @ARG@ @OSP@

[CLS] serial dilutions of a plasmid that contained the target sequence @ARG@ analytical sensitivity of the new assay @ARG@ measured @TRIGGER@ @ sep @ the analytical sensitivity of the new assay was measured with serial dilutions of a plasmid that contained the target sequence , and we determined that down to one copy per reaction of the plasmid was reliably detected . [SEP]

analytical sensitivity of the new assay @ARG@ measured @TRIGGER@ serial dilutions of a plasmid that contained the target sequence @ARG@ @OSP@

[CLS] presence of antibodies against ped ##v @ARG@ ped ##v infection @ARG@ diagnostic assays @ARG@ detection @TRIGGER@ @ sep @ to assess the properties of various diagnostic assays for the detection of ped ##v infection , multiple panels of porcine sera have been shared and tested for the presence of antibodies against ped ##v in an inter - laboratory ring trial . [SEP]

[CLS] 3c ##l ( pro ) [UNK] ligand interactions @ARG@ needed @TRIGGER@ pharmac ##ophore models @ARG@ ligand recognition @ARG@ binding [UNK] pocket regions @ARG@ involved @TRIGGER@ structural features @ARG@ @ sep @ the established pharmac ##ophore models highlight structural features needed for ligand recognition and revealed important binding ‐ pocket regions involved in 3c ##l ( pro ) ‐ ligand interactions . [SEP]

[CLS] incorporated @TRIGGER@ cargo ##es @ARG@ aberrant protein aggregates @ARG@ bacteria @ARG@ autophagosomes @ARG@ autophagy @ARG@ organelles @ARG@ modulate @TRIGGER@ @ sep @ cells are able to modulate autophagy in response to their needs , and under certain circumstances , cargo ##es , such as aberrant protein aggregates , organelles , and bacteria can be selectively and exclusively incorporated into autophagosomes . [SEP]

[CLS] escape @TRIGGER@ immune system of the host organism @ARG@ pathogens @ARG@ complexity of the lipid ##ome @ARG@ allow @TRIGGER@ survival and replication @ARG@ @ sep @ much can be learned from pathogens that have evolved to take advantage of the complexity of the lipid ##ome to escape the immune system of the host organism and to allow their survival and replication . [SEP]

pathogens @ARG@ evolved @TRIGGER@ take advantage of the complexity of the lipid ##ome @ARG@ @OSP@ take advantage of the complexity of the lipid ##ome @ARG@ escape @TRIGGER@ immune system of the host organism @ARG@ @OSP@ pathogens @ARG@ escape @TRIGGER@ immune system of the host organism @ARG@ @OSP@ take advantage of the complexity of the lipid ##ome @ARG@ allow @TRIGGER@ survival @ARG@ @OSP@ take advantage of the complexity of the lipid ##ome @ARG@ allow @TRIGGER@ replication @ARG@ @OSP@ pathogens @ARG@ allow @TRIGGER@ survival @ARG@ @OSP@ pathogens @ARG@ allow @TRIGGER@ replication @ARG@ @OSP@

[CLS] guide @TRIGGER@ efforts in further refinement @ARG@ essential @TRIGGER@ structural fl ##aws @ARG@ detect @TRIGGER@ spectro ##sc ##op ##ists @ARG@ validation of protein structures @ARG@ @ sep @ thus , validation of protein structures is essential for the spectro ##sc ##op ##ists , since it could enable them to detect structural fl ##aws and potentially guide their efforts in further refinement . [SEP]

spectro ##sc ##op ##ists @ARG@ detect @TRIGGER@ structural fl ##aws @ARG@ @OSP@

[CLS] synthesis of the 3 ′ - encoded replication proteins @ARG@ downregulate @TRIGGER@ ribosomes from the message @ARG@ removing @TRIGGER@ frameshift ##ing @ARG@ @ sep @ we suggest that tme ##v evolved frameshift ##ing as a novel mechanism for removing ribosomes from the message ( a “ ribosome sink ” ) to downregulate synthesis of the 3 ′ - encoded replication proteins . [SEP]

tme ##v @ARG@ evolved @TRIGGER@ frameshift ##ing @ARG@ @OSP@ frameshift ##ing @ARG@ downregulate @TRIGGER@ synthesis of the 3 ′ - encoded replication proteins @ARG@ @OSP@ frameshift ##ing @ARG@ removing @TRIGGER@ ribosomes from the message ( a “ ribosome sink ” ) @ARG@ @OSP@

[CLS] cd8 ( + ) and arg * cd11b ( + ) splenic dcs @ARG@ infection with mhv - jh ##m directly ex vivo @ARG@ susceptible @TRIGGER@ @ sep @ although we could not detect infected dcs in vivo , both cd8 ( + ) and cd11b ( + ) splenic dcs were susceptible to infection with mhv - jh ##m directly ex vivo . [SEP]

cd8 ( + ) and cd11b ( + ) splenic dcs @ARG@ susceptible @TRIGGER@ infection with mhv - jh ##m @ARG@ @OSP@

[CLS] inhibitory @TRIGGER@ mers [UNK] cov 3c ##l ( pro ) @ARG@ phenyl ##sulf ##ona ##mid ##e fragment @ARG@ @ sep @ two hits , which share the phenyl ##sulf ##ona ##mid ##e fragment , showed moderate inhibitory activity against the mers ‐ cov 3c ##l ( pro ) and represent a potential starting point for the development of novel anti ‐ mers agents . [SEP]

inhibitory activity @ARG@ against @TRIGGER@ mers ‐ cov 3c ##l ( pro ) @ARG@ @OSP@ two hits @ARG@ development @TRIGGER@ novel anti ‐ mers agents @ARG@ @OSP@

[CLS] host proteins and organelles @ARG@ formation @TRIGGER@ perinuclear or cytoplasmic foci @ARG@ viruses @ARG@ exclude @TRIGGER@ cell organelles @ARG@ recruit @TRIGGER@ @ sep @ for a number of viruses the formation of ‘ factor ##ies ’ has been described , which consist of perinuclear or cytoplasmic foci that mostly exclude host proteins and organelles but recruit specific cell organelles , building a unique structure . [SEP]

[CLS] role @TRIGGER@ canine infectious respiratory disease ( cir ##d ) @ARG@ predisposing @TRIGGER@ further and potentially more serious viral and bacterial infections @ARG@ crc ##ov @ARG@ @ sep @ crc ##ov may play an important role in canine infectious respiratory disease ( cir ##d ) either by predisposing to further and potentially more serious viral and bacterial infections or possibly as a primary pathogen . [SEP]

crc ##ov @ARG@ role @TRIGGER@ canine infectious respiratory disease ( cir ##d ) @ARG@ @OSP@

[CLS] partial duplication of the membrane gene @ARG@ insertion of a new sequence in gene 8a @ARG@ resulting @TRIGGER@ @ sep @ here , we show that this mutant virus reg ##ained fitness after serial passages in cell culture or in vivo , resulting in the partial duplication of the membrane gene or in the insertion of a new sequence in gene 8a , respectively . [SEP]

mutant virus reg ##ained fitness @ARG@ after @TRIGGER@ serial passages in cell culture or in vivo @ARG@ @OSP@ mutant virus reg ##ained fitness @ARG@ resulting @TRIGGER@ partial duplication of the membrane gene @ARG@ @OSP@ mutant virus reg ##ained fitness @ARG@ resulting @TRIGGER@ insertion of a new sequence in gene 8a @ARG@ @OSP@

[CLS] marker @TRIGGER@ necrosis @ARG@ h . som ##ni @ARG@ causes @TRIGGER@ extracellular trap production by bovine neutrophils @ARG@ @ sep @ in this study , we demonstrate that h . som ##ni also causes extracellular trap production by bovine neutrophils in a dose - and time - dependent manner , which did not coincide with the release of lactate dehydrogenase , a marker for necrosis . [SEP]

[CLS] expressed @TRIGGER@ fusion protein @ARG@ enhanced green fluorescent protein ( egfp ) @ARG@ @ sep @ to be able to follow the localization of nsp ##4 , we fused the c terminus of full - length nsp ##4 with the enhanced green fluorescent protein ( egfp ) and expressed this fusion protein induc ##ibly in a hek 293 - based cell line to avoid possible cytotoxicity . [SEP]

fused @TRIGGER@ c terminus of full - length nsp ##4 @ARG@ enhanced green fluorescent protein ( egfp ) @ARG@ @OSP@ hek 293 - based cell line @ARG@ avoid @TRIGGER@ possible cytotoxicity @ARG@ @OSP@

[CLS] [UNK] 1 prf @ARG@ stimulated @TRIGGER@ rna structure beginning 5 to 9 nucleotides ( nt ) downstream of the slip ##per ##y site @ARG@ @ sep @ with few exceptions , −1 prf occurs on specific “ slip ##per ##y ” hept ##an ##ucleotide sequences and is stimulated by rna structure beginning 5 to 9 nucleotides ( nt ) downstream of the slip ##per ##y site . [SEP]

[CLS] tlr3 - signalling pathways @ARG@ endogenous and virus - induced negative regulators of the tlr3 cascade @ARG@ pathogenic @ARG@ protective @TRIGGER@ viral pathogenesis @ARG@ tlr3 @ARG@ @ sep @ we review recent advances in the identification of tlr3 - signalling pathways , endogenous and virus - induced negative regulators of the tlr3 cascade , and discuss the protective versus pathogenic role of tlr3 in viral pathogenesis . [SEP]

[CLS] m protein @ARG@ m and c proteins of the zikv shell @ARG@ using @TRIGGER@ disorder predictor pon ##dr vl ##xt @ARG@ @ sep @ an examination of the m and c proteins of the zikv shell using the disorder predictor pon ##dr vl ##xt revealed that the m protein contains relatively high disorder levels comparable only to those of the yellow fever virus ( yf ##v ) . [SEP]

examination of the m and c proteins of the zikv shell @ARG@ using @TRIGGER@ disorder predictor pon ##dr vl ##xt @ARG@ @OSP@

[CLS] viral surface glycans @ARG@ employ @TRIGGER@ glycan – gb ##p interactions @ARG@ role @TRIGGER@ host cell surface glycan receptors @ARG@ viral pathogenesis @ARG@ target @TRIGGER@ analytical tools @ARG@ @ sep @ this review covers aspects of role of host cell surface glycan receptors and viral surface glycans in viral pathogenesis and offers perspectives on how to employ various analytical tools to target glycan – gb ##p interactions . [SEP]

[CLS] biochemistry and biophys ##ics @ARG@ genetic material of rna viruses @ARG@ viral rna - dependent polymerase structure @ARG@ transc ##ri ##bing @TRIGGER@ replicating @TRIGGER@ involved @TRIGGER@ @ sep @ this review provides an overview of our current understanding of the viral rna - dependent polymerase structure and the biochemistry and biophys ##ics that is involved in replicating and transc ##ri ##bing the genetic material of rna viruses . [SEP]

viral rna - dependent polymerase structure @ARG@ replicating @TRIGGER@ genetic material of rna viruses @ARG@ @OSP@ viral rna - dependent polymerase structure @ARG@ transc ##ri ##bing @TRIGGER@ genetic material of rna viruses @ARG@ @OSP@

[CLS] sars patients with progressive disease after ribavirin treatment @ARG@ given @TRIGGER@ conv ##ales ##cent plasma @ARG@ pulsed methylprednisolone @ARG@ @ sep @ forty sars patients with progressive disease after ribavirin treatment and 1 . 5 g of pulsed methylprednisolone were given either conv ##ales ##cent plasma ( n = 19 ) or further pulsed methylprednisolone ( n = 21 ) in a retrospective non - randomised study . [SEP]

sars patients with progressive disease after ribavirin treatment and 1 . 5 g of pulsed methylprednisolone @ARG@ given @TRIGGER@ conv ##ales ##cent plasma @ARG@ @OSP@ sars patients with progressive disease after ribavirin treatment and 1 . 5 g of pulsed methylprednisolone @ARG@ given @TRIGGER@ pulsed methylprednisolone @ARG@ @OSP@

[CLS] overlapping orfs @ARG@ coding capacity @ARG@ programmed [UNK] 1 ribosomal frameshift ##ing ( [UNK] 1 prf ) @ARG@ produce @TRIGGER@ utilize @TRIGGER@ protein products at a defined ratio @ARG@ translate @TRIGGER@ increase @TRIGGER@ @ sep @ importance many viruses utilize programmed −1 ribosomal frameshift ##ing ( −1 prf ) to produce different protein products at a defined ratio , or to translate overlapping orfs to increase coding capacity . [SEP]

viruses @ARG@ produce @TRIGGER@ different protein products at a defined ratio @ARG@ @OSP@ viruses @ARG@ utilize @TRIGGER@ programmed −1 ribosomal frameshift ##ing ( −1 prf ) @ARG@ @OSP@ viruses @ARG@ increase @TRIGGER@ coding capacity @ARG@ @OSP@

[CLS] proc ##alc ##iton ##in @ARG@ upper respiratory pcr for viral and atypical pathogens @ARG@ band ##emia @ARG@ throat bacterial culture @ARG@ white blood cell count @ARG@ @ sep @ the reference standard for classifying ur ##i etiology was an algorithm that included throat bacterial culture , upper respiratory pcr for viral and atypical pathogens , proc ##alc ##iton ##in , white blood cell count , and band ##emia . [SEP]

[CLS] alanine replacement of charged amino - acid residues of the sud - m domain @ARG@ g - quadruplex - binding @ARG@ caused @TRIGGER@ abrog ##ation of rt ##c activity @ARG@ involved @TRIGGER@ @ sep @ moreover , alanine replacement of charged amino - acid residues of the sud - m domain , which are likely involved in g - quadruplex - binding , caused abrog ##ation of rt ##c activity . [SEP]

alanine replacement of charged amino - acid residues of the sud - m domain @ARG@ caused @TRIGGER@ abrog ##ation of rt ##c activity @ARG@ @OSP@

[CLS] tgf - [UNK] beta [UNK] @ARG@ th17 - like innate immunity - related cytokine @ARG@ il - 6 up - regulation in whole blood of ards patients @ARG@ microarray analysis @ARG@ @ sep @ here , microarray analysis was employed to describe th17 - like innate immunity - related cytokine including tgf - { \ \ beta } and il - 6 up - regulation in whole blood of ards patients . [SEP]

[CLS] antiviral therapeutic or vaccine strategies @ARG@ glycan – gb ##p interactions @ARG@ role @TRIGGER@ viral pathogenesis @ARG@ target @TRIGGER@ @ sep @ the advances in tools and technologies to chemically synthesize and structurally characterize glycans and glycan – gb ##p interactions have offered several insights into the role of glycan – gb ##p interactions in viral pathogenesis and have presented opportunities to target these interactions for novel antiviral therapeutic or vaccine strategies . [SEP]

[CLS] by @TRIGGER@ eic ##osan ##oids @ARG@ pathogens @ARG@ release of polyunsaturated fatty acids from the host cell lipid ##ome @ARG@ target @TRIGGER@ host cell @ARG@ generation @TRIGGER@ pathogen @ARG@ @ sep @ fungal and parasitic pathogens have complex lipid ##omes themselves and target predominantly the release of polyunsaturated fatty acids from the host cell lipid ##ome , resulting in the generation of eic ##osan ##oids by either the host cell or the pathogen . [SEP]

pathogens @ARG@ target @TRIGGER@ release of polyunsaturated fatty acids from the host cell lipid ##ome @ARG@ @OSP@ pathogens @ARG@ generation @TRIGGER@ eic ##osan ##oids @ARG@ @OSP@

[CLS] human isolates of sars - cov @ARG@ bj ##01 @ARG@ civ ##ets @ARG@ gz ##01 @ARG@ inoculated @TRIGGER@ @ sep @ to test the susceptibility of civ ##ets to experimental infection by different sars - cov isolates , 10 civ ##ets were inoculated with two human isolates of sars - cov , bj ##01 ( with a 29 - nucleotide deletion ) and gz ##01 ( without the 29 - nucleotide deletion ) . [SEP]

[CLS] quin ##ine analogues @ARG@ role @TRIGGER@ drugs @ARG@ angiotensin - converting enzyme inhibitors @ARG@ @ sep @ in this contribution , a survey of the current state of knowledge on many and various factors involved in ks pathogenesis is carried out , in particular by highlighting the facts and controvers ##ies about the role of some drugs ( quin ##ine analogues and angiotensin - converting enzyme inhibitors ) in the onset of the disease . [SEP]

[CLS] nsp ##4 @ARG@ virus replication @ARG@ affects @TRIGGER@ leads @TRIGGER@ alteration of the production and distribution of other viral proteins and mrna synthesis @ARG@ inhibition of nsp ##4 expression @ARG@ @ sep @ recent reports show that the inhibition of nsp ##4 expression by small interfering rnas leads to alteration of the production and distribution of other viral proteins and mrna synthesis , suggesting that nsp ##4 also affects virus replication by unknown mechanisms . [SEP]

[CLS] exogenous factors @ARG@ modelling and dynamical systems techniques @ARG@ interactions @TRIGGER@ false detection problems @ARG@ transmission dynamics of cov ##id - 19 @ARG@ analyse @TRIGGER@ limited medical resources @ARG@ @ sep @ to examine the transmission dynamics of cov ##id - 19 and its interactions with some exogenous factors such as limited medical resources and false detection problems , we employ a simple epidemiological model and analyse this system using modelling and dynamical systems techniques . [SEP]

transmission dynamics of cov ##id - 19 @ARG@ analyse @TRIGGER@ modelling and dynamical systems techniques @ARG@ @OSP@ examine @TRIGGER@ transmission dynamics of cov ##id - 19 @ARG@ a simple epidemiological model @ARG@ @OSP@

[CLS] @ sep @ the prevalence of serum antibodies to crc ##ov , in a population of dogs in the south east of england , has been shown previously to be 30 . 1 % on the first day of entry to a reh ##oming ken ##nel [ er ##les , k . , too ##me ##y , c . , brook ##s , h . w . , brown ##li ##e , j . , 2003 . [SEP]

[CLS] clinically significant bacterial infection with host response and acute pathogenic viral infection @ARG@ identify @TRIGGER@ rapid crp / mx ##a immunoassay @ARG@ @ sep @ we conducted a prospective , multicenter , cross - sectional study of adults and children with febrile upper respiratory tract infections ( ur ##is ) to evaluate the diagnostic accuracy of a rapid crp / mx ##a immunoassay to identify clinically significant bacterial infection with host response and acute pathogenic viral infection . [SEP]

prospective , multicenter , cross - sectional study of adults and children with febrile upper respiratory tract infections ( ur ##is ) @ARG@ evaluate @TRIGGER@ diagnostic accuracy of a rapid crp / mx ##a immunoassay @ARG@ @OSP@ diagnostic accuracy of a rapid crp / mx ##a immunoassay @ARG@ identify @TRIGGER@ bacterial infection with host response and acute pathogenic viral infection @ARG@ @OSP@

[CLS] engineer @TRIGGER@ vaccines @ARG@ novel emerging pathogen @ARG@ rapid production technologies @ARG@ computational vaccine design tools @ARG@ wm ##d bio ##war ##far ##e agent counter ##meas ##ures @ARG@ for @TRIGGER@ @ sep @ an alternative approach , proposed here , is to apply computational vaccine design tools and rapid production technologies that now make it possible to engineer vaccines for novel emerging pathogen and wm ##d bio ##war ##far ##e agent counter ##meas ##ures in record time . [SEP]

[CLS] nsp ##4 @ARG@ virus replication @ARG@ involvement @TRIGGER@ lc3 in cap - like structures associated with vir ##oplasm ##s , the site of nascent viral rna replication @ARG@ colocalized @TRIGGER@ @ sep @ in rotavirus - infected cells , nsp ##4 colocalized with lc3 in cap - like structures associated with vir ##oplasm ##s , the site of nascent viral rna replication , suggesting a possible new mechanism for the involvement of nsp ##4 in virus replication . [SEP]

[CLS] transcriptional initiation motif @ARG@ mutations and deletions within the coding region of the mhv - 1 he gene @ARG@ stretch of sequence @ARG@ synthesis of a novel smaller mrna @ARG@ initiate @TRIGGER@ generated @TRIGGER@ @ sep @ however , mutations and deletions within the coding region of the mhv - 1 he gene have generated a stretch of sequence which resembled the transcriptional initiation motif , and was shown to initiate the synthesis of a novel smaller mrna . [SEP]

mutations and deletions within the coding region of the mhv - 1 he gene @ARG@ generated @TRIGGER@ stretch of sequence which resembled the transcriptional initiation motif @ARG@ @OSP@ stretch of sequence which resembled the transcriptional initiation motif @ARG@ initiate @TRIGGER@ synthesis of a novel smaller mrna @ARG@ @OSP@

[CLS] hep ##aci ##virus ( hcv ) @ARG@ hep ##ad ##na ##virus ( hbv ) @ARG@ myx ##ovirus ( influenza , rsv ) infections @ARG@ therapy @TRIGGER@ herpesvirus ( hsv , vzv , cmv ) @ARG@ @ sep @ the others have been approved for the therapy of herpesvirus ( hsv , vzv , cmv ) , hep ##ad ##na ##virus ( hbv ) , hep ##aci ##virus ( hcv ) and myx ##ovirus ( influenza , rsv ) infections . [SEP]

[CLS] inhibitors of rsv - induced cyto ##path ##ic effect @ARG@ screen @TRIGGER@ cell - based high - throughput screening assay @ARG@ infectious material @ARG@ frozen rsv - infected cells @ARG@ source @TRIGGER@ @ sep @ using frozen rsv - infected cells as the source of infectious material , we have overcome the problem of virus instability and validated a cell - based high - throughput screening assay to screen for inhibitors of rsv - induced cyto ##path ##ic effect . [SEP]

cell - based high - throughput screening assay @ARG@ screen @TRIGGER@ inhibitors of rsv - induced cyto ##path ##ic effect @ARG@ @OSP@ frozen rsv - infected cells @ARG@ source @TRIGGER@ infectious material @ARG@ @OSP@

[CLS] ibd ##v genomic rna from burs ##a and spleen tissue specimens @ARG@ ibd ##v strains in tissue samples from experimentally infected and commercially reared chickens @ARG@ detect @TRIGGER@ isolation @TRIGGER@ dot blot hybridization assay @ARG@ @ sep @ a rapid procedure for isolation of ibd ##v genomic rna from burs ##a and spleen tissue specimens was developed and used with the dot blot hybridization assay to detect ibd ##v strains in tissue samples from experimentally infected and commercially reared chickens . [SEP]

rapid procedure @ARG@ isolation @TRIGGER@ ibd ##v genomic rna @ARG@ @OSP@ rapid procedure @ARG@ detect @TRIGGER@ ibd ##v strains in tissue samples @ARG@ @OSP@

[CLS] against @TRIGGER@ mers - cov @ARG@ cross - reactivity of the sars - cov - specific immunity @ARG@ t - cell immunological studies of sars - cov @ARG@ @ sep @ herein , we summarize t - cell immunological studies of sars - cov and discuss the potential cross - reactivity of the sars - cov - specific immunity against mers - cov , which may provide useful recommendations for the development of broad - spectrum vaccines against coron ##avirus infections . [SEP]

broad - spectrum vaccines @ARG@ against @TRIGGER@ coron ##avirus infections @ARG@ @OSP@ cross - reactivity of the sars - cov - specific immunity @ARG@ against @TRIGGER@ mers - cov @ARG@ @OSP@

[CLS] dependent @TRIGGER@ stem - loop structure @ARG@ @ sep @ here we describe an unusual case of −1 prf in the ##iler ' s murine encephal ##omyelitis virus ( tme ##v ) that is extraord ##inarily efficient ( 74 to 82 % of ribosomes shift into the alternative reading frame ) and , in stark contrast to other examples of −1 prf , is dependent upon a stem - loop structure beginning 14 nt downstream of the slip ##per ##y site . [SEP]

−1 prf in the ##iler ' s murine encephal ##omyelitis virus ( tme ##v ) @ARG@ dependent @TRIGGER@ stem - loop structure @ARG@ @OSP@

[CLS] by @TRIGGER@ recently circulating strains ( indel and non - indel ) @ARG@ early european strains of ped ##v @ARG@ infection of pigs at a herd level @ARG@ detect @TRIGGER@ assays @ARG@ @ sep @ although different characteristics were found , it can be concluded that each of the assays used can detect infection of pigs at a herd level by either the early european strains of ped ##v or the recently circulating strains ( indel and non - indel ) . [SEP]

each of the assays @ARG@ detect @TRIGGER@ infection of pigs at a herd level @ARG@ @OSP@

[CLS] required @TRIGGER@ control an epidemic @ARG@ reproduction number , r , defined as the average number of secondary cases generated by a primary case , is a crucial quantity for trigger * identifying * trigger the arg * intensity of interventions @ARG@ identifying @TRIGGER@ @ sep @ the reproduction number , r , defined as the average number of secondary cases generated by a primary case , is a crucial quantity for identifying the intensity of interventions required to control an epidemic . [SEP]

r @ARG@ identifying @TRIGGER@ intensity of interventions required to control an epidemic @ARG@ @OSP@

[CLS] translational diffusion of i - ak molecules in the plasma membrane @ARG@ carboxy - terminal six amino acids of the cytoplasmic domain of the alpha chain @ARG@ constrain ##ing @TRIGGER@ @ sep @ these data indicate that the carboxy - terminal six amino acids of the cytoplasmic domain of the alpha chain and the six plasma membrane - proximal amino acids of the beta chain are important in constrain ##ing the translational diffusion of i - ak molecules in the plasma membrane . [SEP]

carboxy - terminal six amino acids of the cytoplasmic domain of the alpha chain @ARG@ constrain ##ing @TRIGGER@ translational diffusion of i - ak molecules in the plasma membrane @ARG@ @OSP@ plasma membrane - proximal amino acids of the beta chain @ARG@ constrain ##ing @TRIGGER@ translational diffusion of i - ak molecules in the plasma membrane @ARG@ @OSP@

[CLS] required @TRIGGER@ virus infection @ARG@ predicted 3 ′ rna stem - loop structure at a nonc ##ano ##nic ##al spacing downstream of the shift site @ARG@ efficient frameshift ##ing in tme ##v @ARG@ frameshift ##ing @ARG@ requires @TRIGGER@ @ sep @ in addition , we demonstrate that a predicted 3 ′ rna stem - loop structure at a nonc ##ano ##nic ##al spacing downstream of the shift site is required for efficient frameshift ##ing in tme ##v and that frameshift ##ing also requires virus infection . [SEP]

3 ′ rna stem - loop structure @ARG@ required @TRIGGER@ efficient frameshift ##ing in tme ##v @ARG@ @OSP@

[CLS] shielding ##s @ARG@ validation @TRIGGER@ computational methods @ARG@ ( 13 ) c ( [UNK] ) nuclei @ARG@ protein structures @ARG@ determination @TRIGGER@ @ sep @ the ( 13 ) c ( α ) nuclei are ubiquitous in proteins , moreover , their shielding ##s are easily obtain ##able from nmr experiments and represent a rich source of encoded structural information that makes ( 13 ) c ( α ) chemical shifts an attractive candidate for use in computational methods aimed at determination and validation of protein structures . [SEP]

[CLS] incorporated @TRIGGER@ pdz - binding motif ( pb ##m ) @ARG@ novel chimeric protein with a pb ##m @ARG@ sequence of the pb ##m on the e protein @ARG@ full - length e protein @ARG@ restored @TRIGGER@ @ sep @ when the full - length e protein was deleted or its pdz - binding motif ( pb ##m ) was mutated , the revert ##ant viruses either incorporated a novel chimeric protein with a pb ##m or restored the sequence of the pb ##m on the e protein , respectively . [SEP]

revert ##ant viruses @ARG@ incorporated @TRIGGER@ novel chimeric protein with a pb ##m @ARG@ @OSP@ revert ##ant viruses @ARG@ restored @TRIGGER@ sequence of the pb ##m on the e protein @ARG@ @OSP@

[CLS] @ sep @ nsp ##4 - egfp did not enter the golgi apparatus , in agreement with the endo h sensitivity and a previous report that secretion of an nsp ##4 cleavage product generated in rotavirus - infected cells is not inhibited by bre ##feld ##in a . a significant population of expressed nsp ##4 - egfp was distributed in novel vesicular structures throughout the cytoplasm , not colocal ##izing with er , erg ##ic , golgi , endosomal , or lysosomal markers , thus diverg ##ing from known biosynthetic pathways . [SEP]

[CLS] sud - nm @ARG@ forming @TRIGGER@ poly ( adp - ribose ) - binding protein @ARG@ oligo ( g ) - nucleotides @ARG@ x domain @ARG@ g - quadruplex ##es @ARG@ adp - ribose - 1 ” - phosphatase @ARG@ binds @TRIGGER@ @ sep @ the x domain was proposed to be an adp - ribose - 1 ” - phosphatase or a poly ( adp - ribose ) - binding protein , whereas sud - nm binds oligo ( g ) - nucleotides capable of forming g - quadruplex ##es . [SEP]

sud - nm @ARG@ binds @TRIGGER@ oligo ( g ) - nucleotides @ARG@ @OSP@ oligo ( g ) - nucleotides @ARG@ forming @TRIGGER@ g - quadruplex ##es @ARG@ @OSP@

[CLS] infected @TRIGGER@ dysregulated immune response @ARG@ a5 ##9 strain ( mhv - a5 ##9 ) @ARG@ dcs @ARG@ ) @ARG@ key @TRIGGER@ infection of these cells @ARG@ @ sep @ dendritic cells ( dcs ) are key cells in the initiation of innate and adaptive immune responses , and infection of these cells could potentially contribute to a dysregulated immune response ; consistent with this , recent results suggest that dcs are readily infected by another strain of mouse hepatitis virus , the a5 ##9 strain ( mhv - a5 ##9 ) . [SEP]

[CLS] detection @TRIGGER@ quantitative reverse transcription real time polymerase chain reactions ( rt real time qt - pcrs ) @ARG@ hpi ##v - 1 , - 2 and - 3 in clinical samples @ARG@ indirect immunofluorescence ( ifa ) @ARG@ quantitation @TRIGGER@ @ sep @ the development and optimization of three quantitative reverse transcription real time polymerase chain reactions ( rt real time qt - pcrs ) and an indirect immunofluorescence ( ifa ) for the detection and quantitation of hpi ##v - 1 , - 2 and - 3 in clinical samples are described . [SEP]

quantitative reverse transcription real time polymerase chain reactions ( rt real time qt - pcrs ) @ARG@ detection @TRIGGER@ hpi ##v - 1 , - 2 and - 3 in clinical samples @ARG@ @OSP@ indirect immunofluorescence ( ifa ) @ARG@ detection @TRIGGER@ hpi ##v - 1 , - 2 and - 3 in clinical samples @ARG@ @OSP@ quantitative reverse transcription real time polymerase chain reactions ( rt real time qt - pcrs ) @ARG@ quantitation @TRIGGER@ hpi ##v - 1 , - 2 and - 3 in clinical samples @ARG@ @OSP@ indirect immunofluorescence ( ifa ) @ARG@ quantitation @TRIGGER@ hpi ##v - 1 , - 2 and - 3 in clinical samples @ARG@ @OSP@

[CLS] by @TRIGGER@ modulation of proteolytic cleavage of viral proteins @ARG@ dynamic interplay between the virus and the host @ARG@ recognition and neutralization of virus @ARG@ host immune system @ARG@ viral entry into host cell @ARG@ complex glycans @ARG@ roles @TRIGGER@ @ sep @ the surfaces of host cells and viruses are decorated by complex glycans , which play multifaceted roles in the dynamic interplay between the virus and the host including viral entry into host cell , modulation of proteolytic cleavage of viral proteins , recognition and neutralization of virus by host immune system . [SEP]

surfaces of host cells and viruses @ARG@ decorated @TRIGGER@ complex glycans @ARG@ @OSP@ complex glycans @ARG@ roles @TRIGGER@ dynamic interplay between the virus and the host @ARG@ @OSP@ complex glycans @ARG@ roles @TRIGGER@ viral entry into host cell @ARG@ @OSP@ complex glycans @ARG@ roles @TRIGGER@ modulation of proteolytic cleavage of viral proteins @ARG@ @OSP@ complex glycans @ARG@ roles @TRIGGER@ recognition and neutralization of virus @ARG@ @OSP@ recognition and neutralization of virus @ARG@ by @TRIGGER@ host immune system @ARG@ @OSP@

[CLS] cofactors @ARG@ favoring @TRIGGER@ lymph flow disorders @ARG@ environmental factors @ARG@ onset of the disease @ARG@ modulating @TRIGGER@ role @TRIGGER@ inhibiting @TRIGGER@ pathogenesis itself @ARG@ drug intake @ARG@ genetic predisposition @ARG@ @ sep @ based on these assessments , it is possible to hypothesize that the role of cofactors in ks pathogenesis can move toward an effect either favoring or inhibiting the onset of the disease , depending on the presence of other agents modulating the pathogenesis itself , such as genetic predisposition , environmental factors , drug intake , or lymph flow disorders . [SEP]

[CLS] pox ##virus vectors ( vaccinia wr and can ##ary ##po ##x ) expressing only the fi ##pv membrane ( m ) protein @ARG@ elicit @TRIGGER@ partially protective immunity @ARG@ @ sep @ however , two studies have shown that pox ##virus vectors ( vaccinia wr and can ##ary ##po ##x ) expressing only the fi ##pv membrane ( m ) protein can elicit a partially protective immunity which is supposed to be cell - mediated ( virolog ##y 181 ( 1991 ) 327 ; international patent wo 97 / 2005 ##4 ( 1997 ) ) . [SEP]

pox ##virus vectors ( vaccinia wr and can ##ary ##po ##x ) @ARG@ elicit @TRIGGER@ partially protective immunity @ARG@ @OSP@ pox ##virus vectors ( vaccinia wr and can ##ary ##po ##x ) @ARG@ expressing @TRIGGER@ fi ##pv membrane ( m ) protein @ARG@ @OSP@

[CLS] induce * trigger ##pr ##ima ##ri ##ly arg * alterations in lipid metabolites at the host cell level * arg , arg * eukaryotic pathogens * arg focus on arg * interference with lipid metabolites * arg trigger * affecting @TRIGGER@ interference with lipid metabolites @ARG@ systemic inflammatory reactions @ARG@ eukaryotic pathogens @ARG@ alterations in lipid metabolites at the host cell level @ARG@ @ sep @ thus , whereas viruses and bacteria induce predominantly alterations in lipid metabolites at the host cell level , eukaryotic pathogens focus on interference with lipid metabolites affecting systemic inflammatory reactions that are part of the immune system . [SEP]

viruses @ARG@ alterations @TRIGGER@ lipid metabolites at the host cell level @ARG@ @OSP@ bacteria @ARG@ alterations @TRIGGER@ lipid metabolites at the host cell level @ARG@ @OSP@ eukaryotic pathogens @ARG@ interference @TRIGGER@ lipid metabolites affecting systemic inflammatory reactions @ARG@ @OSP@

[CLS] representing @TRIGGER@ used @TRIGGER@ molecular clone @ARG@ 445 base pairs at the 3 ' end of infectious burs ##al disease virus ( ibd ##v ) genome segment b @ARG@ detect @TRIGGER@ viral rna from cell culture and from chicken burs ##a and spleen tissue specimens @ARG@ dot blot hybridization assay @ARG@ @ sep @ a molecular clone representing 445 base pairs at the 3 ' end of infectious burs ##al disease virus ( ibd ##v ) genome segment b was used in a dot blot hybridization assay to detect viral rna from cell culture and from chicken burs ##a and spleen tissue specimens . [SEP]

molecular clone representing 445 base pairs at the 3 ' end of infectious burs ##al disease virus ( ibd ##v ) genome segment b @ARG@ used @TRIGGER@ dot blot hybridization assay @ARG@ @OSP@

[CLS] barrier @TRIGGER@ increases @TRIGGER@ facilitate @TRIGGER@ risk of a new influenza pandemic @ARG@ cross [UNK] species transmission of influenza a viruses ( iav ##s ) @ARG@ promote @TRIGGER@ repeated intersp ##ec ##ies transmission events @ARG@ reass ##ort ##ment between animal influenza strains @ARG@ @ sep @ the risk of a new influenza pandemic increases with the repeated intersp ##ec ##ies transmission events that facilitate reass ##ort ##ment between animal influenza strains ; thus , it is of ut ##most importance to understand the factors involved that promote or become a barrier to cross ‐ species transmission of influenza a viruses ( iav ##s ) . [SEP]

risk of a new influenza pandemic @ARG@ increases @TRIGGER@ repeated intersp ##ec ##ies transmission events @ARG@ @OSP@ repeated intersp ##ec ##ies transmission events @ARG@ facilitate @TRIGGER@ reass ##ort ##ment between animal influenza strains @ARG@ @OSP@

[CLS] feline cal ##ici ##virus ( fc ##v ) @ARG@ chlamyd ##ophila fel ##is @ARG@ bor ##de ##te ##ll ##a bronchi ##se ##ptic ##a @ARG@ quantitative real - time pcr ( qpcr ) @ARG@ tested @TRIGGER@ mycoplasma fel ##is @ARG@ feline herpesvirus type 1 ( fh ##v - 1 ) @ARG@ @ sep @ combined conjunctival and oropharyngeal swab specimens were tested by quantitative real - time pcr ( qpcr ) for feline herpesvirus type 1 ( fh ##v - 1 ) , feline cal ##ici ##virus ( fc ##v ) , mycoplasma fel ##is , chlamyd ##ophila fel ##is , and bor ##de ##te ##ll ##a bronchi ##se ##ptic ##a . [SEP]

conjunctival and oropharyngeal swab specimens @ARG@ tested @TRIGGER@ quantitative real - time pcr ( qpcr ) @ARG@ @OSP@ quantitative real - time pcr ( qpcr ) @ARG@ for @TRIGGER@ feline herpesvirus type 1 ( fh ##v - 1 ) @ARG@ @OSP@ quantitative real - time pcr ( qpcr ) @ARG@ for @TRIGGER@ feline cal ##ici ##virus ( fc ##v ) @ARG@ @OSP@ quantitative real - time pcr ( qpcr ) @ARG@ for @TRIGGER@ mycoplasma fel ##is @ARG@ @OSP@ quantitative real - time pcr ( qpcr ) @ARG@ for @TRIGGER@ chlamyd ##ophila fel ##is @ARG@ @OSP@ quantitative real - time pcr ( qpcr ) @ARG@ for @TRIGGER@ bor ##de ##te ##ll ##a bronchi ##se ##ptic ##a @ARG@ @OSP@

[CLS] had ##v - 3 mutant @ARG@ double knock out ( had ##v - 3 n - tag dko ) mutant virus @ARG@ small epitope tags at the n - termini of both e3 - cr ##1 [UNK] and e3 - cr ##1 [UNK] @ARG@ encoding @TRIGGER@ @ sep @ we generated a had ##v - 3 mutant encoding small epitope tags at the n - termini of both e3 - cr ##1 ##β and e3 - cr ##1 ##γ ( had ##v - 3 n - tag wt ) and a double knock out ( had ##v - 3 n - tag dko ) mutant virus that does not express either protein . [SEP]

had ##v - 3 mutant @ARG@ encoding @TRIGGER@ small epitope tags at the n - termini of both e3 - cr ##1 ##β and e3 - cr ##1 ##γ ( had ##v - 3 n - tag wt ) @ARG@ @OSP@

[CLS] corticosteroids @ARG@ speed @TRIGGER@ acute ventilatory failure @ARG@ reduce @TRIGGER@ treatment @TRIGGER@ likelihood of treatment failures @ARG@ antibiotics @ARG@ non - invasive positive - pressure ventilation @ARG@ inhaled bronchodil ##ators @ARG@ recovery @ARG@ supplemental oxygen @ARG@ @ sep @ although studies of many fundamental aspects of management are still needed , the results of controlled clinical trials are sufficient to emphasis ##e the importance of a careful clinical assessment , supplemental oxygen , inhaled bronchodil ##ators to partially improve airway obstruction , corticosteroids to decrease the likelihood of treatment failures and to speed recovery , antibiotics , especially in severe patients , and non - invasive positive - pressure ventilation for treatment of acute ventilatory failure in selected patients . [SEP]

[CLS] confusion @ARG@ hypox ##aemia @ARG@ associated @TRIGGER@ early cid ##ofovir treatment @ARG@ early cid ##ofovir treatment within 7 days from symptom onset @ARG@ monocyte count @ARG@ whole lung involvement @ARG@ @ sep @ on multivariate analysis , monocyte count , hypox ##aemia , confusion , whole lung involvement , and early cid ##ofovir treatment within 7 days from symptom onset were included , and monocyte count ( hr 0 . 99 ##5 , 95 % ci 0 . 99 ##1 – 1 . 000 , p 0 . 042 ) , confusion ( hr 4 . 96 ##4 , 95 % ci 1 . 189 – 20 . 72 ##1 , p = 0 . 028 ) , and early cid ##ofovir treatment ( hr 0 . 319 , 95 % ci 0 . 115 – 0 . 88 ##3 , p = 0 . 028 ) were significantly associated with respiratory failure . [SEP]

pharmac ##ophore modeling study @ARG@ supported @TRIGGER@ in vitro validation on the mers [UNK] cov 3c ##l ( pro ) @ARG@ @OSP@

enable @TRIGGER@ intersp ##ec ##ies transmission of the various virus gene segments @ARG@ @OSP@

immunological adjuvants @ARG@ enhance @TRIGGER@ pox ##virus - based cd8 ( + ) t - cell vaccines @ARG@ @OSP@

reverse genetic approach @ARG@ assess @TRIGGER@ importance of these macro ##dom ##ains @ARG@ @OSP@

hk ##u ##4 [UNK] cov 3c ##l ( pro ) @ARG@ identification @TRIGGER@ mers [UNK] cov 3c ##l ( pro ) enzyme inhibitors @ARG@ @OSP@

roles @ARG@ mediated @TRIGGER@ multiv ##alent interactions of glycans with their cognate proteins @ARG@ @OSP@ glycan - binding proteins @ARG@ mediated @TRIGGER@ lectins @ARG@ @OSP@

hist ##ophilus som ##ni @ARG@ causes @TRIGGER@ respiratory , reproductive , cardiac and neuronal diseases in cattle @ARG@ @OSP@

elisa @ARG@ test @TRIGGER@ presence of antibodies to crc ##ov in canine serum samples @ARG@ @OSP@ elisa @ARG@ identified @TRIGGER@ seropositive dogs @ARG@ @OSP@

multi - domain non - structural protein 3 of sars - coron ##avirus @ARG@ component @TRIGGER@ viral replication / transcription complex ( rt ##c ) @ARG@ @OSP@

correlate @TRIGGER@ diagnostic real - time pcr results @ARG@ correlate @TRIGGER@ histopathologic lesions in cats with clinical signs of upper respiratory infection ( ur ##i ) @ARG@ @OSP@

zikv @ARG@ causes @TRIGGER@ microc ##ep ##hal ##ly in the babies of mothers infected during pregnancy @ARG@ @OSP@

analytical sensitivity of the new assay @ARG@ measured @TRIGGER@ serial dilutions of a plasmid that contained the target sequence @ARG@ @OSP@

pharmac ##ophore models @ARG@ needed @TRIGGER@ ligand recognition @ARG@ @OSP@ binding [UNK] pocket regions @ARG@ involved @TRIGGER@ 3c ##l ( pro ) [UNK] ligand interactions @ARG@ @OSP@

pathogens @ARG@ escape @TRIGGER@ immune system of the host organism @ARG@ @OSP@ complexity of the lipid ##ome @ARG@ allow @TRIGGER@ survival and replication @ARG@ @OSP@

validation of protein structures @ARG@ detect @TRIGGER@ structural fl ##aws @ARG@ @OSP@ validation of protein structures @ARG@ guide @TRIGGER@ efforts in further refinement @ARG@ @OSP@

cd8 ( + ) and arg ( + ) splenic dcs @ARG@ susceptible @TRIGGER@ infection with mhv - jh ##m directly ex vivo @ARG@ @OSP@

phenyl ##sulf ##ona ##mid ##e fragment @ARG@ inhibitory @TRIGGER@ mers [UNK] cov 3c ##l ( pro ) @ARG@ @OSP@

crc ##ov @ARG@ role @TRIGGER@ canine infectious respiratory disease ( cir ##d ) @ARG@ @OSP@ crc ##ov @ARG@ predisposing @TRIGGER@ further and potentially more serious viral and bacterial infections @ARG@ @OSP@

@ @TRIGGER@ partial duplication of the membrane gene @ARG@ resulting @TRIGGER@ insertion of a new sequence in gene 8a @ARG@ @OSP@

h . som ##ni @ARG@ causes @TRIGGER@ extracellular trap production by bovine neutrophils @ARG@ @OSP@

fusion protein @ARG@ expressed @TRIGGER@ enhanced green fluorescent protein ( egfp ) @ARG@ @OSP@

prf @ARG@ stimulated @TRIGGER@ rna structure beginning 5 to 9 nucleotides ( nt ) downstream of the slip ##per ##y site @ARG@ @OSP@

m and c proteins of the zikv shell @ARG@ using @TRIGGER@ disorder predictor pon ##dr vl ##xt @ARG@ @OSP@

role @TRIGGER@ host cell surface glycan receptors @ARG@ viral pathogenesis @ARG@ @OSP@ viral surface glycans @ARG@ target @TRIGGER@ glycan – gb ##p interactions @ARG@ @OSP@

viral rna - dependent polymerase structure @ARG@ involved @TRIGGER@ replicating @TRIGGER@ @OSP@ biochemistry and biophys ##ics @ARG@ involved @TRIGGER@ genetic material of rna viruses @ARG@ @OSP@

sars patients with progressive disease after ribavirin treatment @ARG@ given @TRIGGER@ conv ##ales ##cent plasma @ARG@ @OSP@ pulsed methylprednisolone @ARG@ given @TRIGGER@ pulsed methylprednisolone @ARG@ @OSP@

throat bacterial culture @ARG@ throat bacterial culture @ARG@ @OSP@ throat bacterial culture @ARG@ proc ##alc ##iton ##in @ARG@ @OSP@ proc ##alc ##iton count @ARG@ band ##emia @ARG@ @OSP@

alanine replacement of charged amino - acid residues of the sud - m domain @ARG@ involved @TRIGGER@ g - quadruplex - binding @ARG@ @OSP@ g - quadruplex - binding @ARG@ caused @TRIGGER@ abrog ##ation of rt ##c activity @ARG@ @OSP@

microarray analysis @ARG@ tgf - [UNK] beta [UNK] @ARG@ @OSP@ tgf - [UNK] beta [UNK] @ARG@ il - 6 up - regulation in whole blood of ards patients @ARG@ @OSP@

role @TRIGGER@ glycan – gb ##p interactions @ARG@ viral pathogenesis @ARG@ @OSP@ target @TRIGGER@ glycan – gb ##p interactions @ARG@ antiviral therapeutic or vaccine strategies @ARG@ @OSP@

pathogens @ARG@ target @TRIGGER@ release of polyunsaturated fatty acids from the host cell lipid ##ome @ARG@ @OSP@ pathogens @ARG@ generation @TRIGGER@ eic ##osan ##oids @ARG@ @OSP@

inhibition of nsp ##4 expression @ARG@ leads @TRIGGER@ alteration of the production and distribution of other viral proteins and mrna synthesis @ARG@ @OSP@ nsp ##4 @ARG@ affects @TRIGGER@ virus replication @ARG@ @OSP@

antibodies , crc ##ov to crc ##ov , crc ##ov , crc ##ov , h . w . , brown ##li ##e , j . , brown ##li ##e , j . , brown ##li ##e , j . , brown ##li ##e , j . , brown ##li ##e , j . , brown ##li ##e , j . , brown ##li ##e , j . , brown ##li ##e , j . , brown ##li ##e , j . , brown ##li ##e , j . , brown ##li ##e , j . ,

rapid crp / mx ##a immunoassay @ARG@ identify @TRIGGER@ clinically significant bacterial infection with host response and acute pathogenic viral infection @ARG@ @OSP@

computational vaccine design tools @ARG@ engineer @TRIGGER@ vaccines @ARG@ @OSP@ vaccines @ARG@ for @TRIGGER@ novel emerging pathogen @ARG@ @OSP@ rapid production technologies @ARG@ for @TRIGGER@ wm ##d bio ##war ##far ##e agent counter ##meas ##ures @ARG@ @OSP@

nsp ##4 @ARG@ colocalized @TRIGGER@ lc3 in cap - like structures associated with vir ##oplasm ##s , the site of nascent viral rna replication @ARG@ @OSP@ nsp ##4 @ARG@ involvement @TRIGGER@ virus replication @ARG@ @OSP@

mutations and deletions within the coding region of the mhv - 1 he gene @ARG@ generated @TRIGGER@ stretch of sequence @ARG@ @OSP@ stretch of sequence @ARG@ initiate @TRIGGER@ synthesis of a novel smaller mrna @ARG@ @OSP@

therapy @TRIGGER@ herpesvirus ( hsv , vzv , cmv ) @ARG@ @OSP@ hep ##ad ##na ##virus ( hbv ) @ARG@ hep ##aci ##virus ( hcv ) @ARG@ @OSP@

frozen rsv - infected cells @ARG@ source @TRIGGER@ infectious material @ARG@ @OSP@ cell - based high - throughput screening assay @ARG@ screen @TRIGGER@ inhibitors of rsv - induced cyto ##path ##ic effect @ARG@ @OSP@

isolation @TRIGGER@ ibd ##v genomic rna from burs ##a and spleen tissue specimens @ARG@ @OSP@ dot blot hybridization assay @ARG@ detect @TRIGGER@ ibd ##v strains in tissue samples from experimentally infected and commercially reared chickens @ARG@ @OSP@

t - cell immunological studies of sars - cov @ARG@ against @TRIGGER@ mers - cov @ARG@ @OSP@

@ @TRIGGER@ −1 prf in the ##iler ' s murine ##omyelitis virus ( tme ##v ) @ARG@ dependent @TRIGGER@ stem - loop structure @ARG@ @OSP@

assays @ARG@ detect @TRIGGER@ infection of pigs at a herd level @ARG@ @OSP@ assays @ARG@ by @TRIGGER@ recently circulating strains ( indel and non - indel ) @ARG@ @OSP@

reproduction number , r , defined as the average number of secondary cases generated by a primary case , is a crucial quantity for trigger @TRIGGER@ reproduction number , r , defined as the average number of secondary cases generated by a primary case , is a crucial quantity for trigger @TRIGGER@ intensity of interventions @ARG@ required @TRIGGER@ control an epidemic @ARG@ @OSP@

carboxy - terminal six amino acids of the cytoplasmic domain of the alpha chain @ARG@ constrain ##ing @TRIGGER@ translational diffusion of i - ak molecules in the plasma membrane @ARG@ @OSP@

predicted 3 ′ rna stem - loop structure at a nonc ##ano ##nic ##al structure at a nonc ##ano ##nic ##al structure at a nonc ##ano ##nic ##al structure at a nonc ##ano ##nic ##al structure at a nonc ##ano ##nic ##al structure at a nonc ##ano ##nic ##al structure at a nonc ##ano ##nic ##al structure at a nonc ##ano ##nic ##al structure at a nonc ##ano ##nic ##al structure at a nonc ##ano ##nic ##al structure at a nonc ##ano ##nic ##al structure at a nonc ##ano ##nic ##al structure at a nonc ##ano

( 13 ) c ( [UNK] ) nuclei @ARG@ determination @TRIGGER@ protein structures @ARG@ @OSP@ ( 13 ) c ( [UNK] ) nuclei @ARG@ validation @TRIGGER@ protein structures @ARG@ @OSP@

full - length e protein @ARG@ incorporated @TRIGGER@ novel chimeric protein with a pb ##m @ARG@ @OSP@ pdz - binding motif ( pb ##m ) @ARG@ restored @TRIGGER@ sequence of the pb ##m on the e protein @ARG@ @OSP@

nsp ##4 - egfp ##4 - egfp ##4 - egfp ##4 - egfp did enter of an nsp ##4 - egfp ##4 - egfp did enter of an nsp ##4 - egfp ##4 - egfp did enter the nsp ##4 - egfp ##4 - egfp did enter the nsp ##4 - egfp did enter the nsp ##4 - egfp did enter the nsp ##4 - egfp did enter from nsp ##4 - egfp did enter from nsp ##4 - egfp did enter from nsp ##4 - egfp did enter from nsp ##4 - egfp did enter

x domain @ARG@ binds @TRIGGER@ adp - ribose - 1 ” - phosphatase @ARG@ @OSP@ poly ( adp - ribose ) - binding protein @ARG@ binds @TRIGGER@ oligo ( g ) - nucleotides @ARG@ @OSP@ sud - nm @ARG@ forming @TRIGGER@ g - quadruplex ##es @ARG@ @OSP@

quantitative reverse transcription real time polymerase chain reactions ( rt real time qt - pcrs ) @ARG@ detection @TRIGGER@ hpi ##v - 1 , - 2 and - 3 in clinical samples @ARG@ @OSP@ indirect immunofluorescence ( ifa ) @ARG@ quantitation @TRIGGER@ hpi ##v - 1 , - 2 and - 3 in clinical samples @ARG@ @OSP@

complex glycans @ARG@ roles @TRIGGER@ dynamic interplay between the virus and the host @ARG@ @OSP@ viral entry into host cell @ARG@ modulation of proteolytic cleavage of viral proteins @ARG@ @OSP@ recognition and neutralization of virus @ARG@ by @TRIGGER@ host immune system @ARG@ @OSP@

pox ##virus vectors ( vaccinia wr and can ##ary ##po ##x ) expressing only the fi ##pv membrane ( m ) protein @ARG@ elicit @TRIGGER@ partially protective immunity @ARG@ @OSP@

arg * induce * trigger * lipid metabolites at the host cell level @ARG@ induce * alterations in lipid metabolites at the host cell level @ARG@ @OSP@ arg * eukaryotic pathogens * arg focus on arg , arg @TRIGGER@ interference with lipid metabolites @ARG@ interference with lipid metabolites @ARG@ @OSP@ eukaryotic pathogens @ARG@ affecting @TRIGGER@ systemic inflammatory reactions @ARG@ @OSP@

molecular clone @ARG@ representing @TRIGGER@ 445 base pairs at the 3 ' end of infectious burs ##al disease virus ( ibd ##v ) genome segment b @ARG@ @OSP@ dot blot hybridization assay @ARG@ detect @TRIGGER@ viral rna from cell culture and from chicken burs ##a and spleen tissue specimens @ARG@ @OSP@

risk of a new influenza pandemic @ARG@ promote @TRIGGER@ repeated intersp ##ec ##ies transmission events @ARG@ @OSP@ repeated intersp ##ec ##ies transmission events @ARG@ facilitate @TRIGGER@ reass ##ort ##ment between animal influenza strains @ARG@ @OSP@ barrier @TRIGGER@ cross [UNK] species transmission of influenza a viruses ( iav ##s ) @ARG@ @OSP@

tested @TRIGGER@ feline herpesvirus type 1 ( fh ##v - 1 ) @ARG@ tested @TRIGGER@ quantitative real - time pcr ( qpcr ) @ARG@ @OSP@ feline cal ##ici ##virus ( fc ##v ) @ARG@ tested @TRIGGER@ mycoplasma fel ##is @ARG@ @OSP@ feline cal ##ici ##virus ( fc ##v ) @ARG@ bor ##de ##te ##ll ##a bronchi ##se ##ptic ##a @ARG@ @OSP@

had ##v - 3 mutant @ARG@ encoding @TRIGGER@ small epitope tags at the n - termini of both e3 - cr ##1 [UNK] and e3 - cr ##1 [UNK] @ARG@ @OSP@ double knock out ( had ##v - 3 n - tag dko ) mutant virus @ARG@ encoding @TRIGGER@ double knock out ( had ##v - 3 n - tag dko ) mutant virus @ARG@ @OSP@

antibody @ARG@ transferred @TRIGGER@ colostrum @ARG@ @OSP@ pups @ARG@ capable @TRIGGER@ absorption through 2 weeks of age @ARG@ @OSP@

public education campaign @ARG@ educate @TRIGGER@ singaporeans @ARG@ sars @ARG@ @OSP@ public education campaign @ARG@ prevent @TRIGGER@ spread of the disease @ARG@ @OSP@

pharmacophore modeling study @ARG@ supported @TRIGGER@ in vitro validation on the mers [UNK] cov 3cl ( pro ) @ARG@ @OSP@

3d queries @ARG@ used @TRIGGER@ 3d queries @ARG@ @OSP@ 3d queries @ARG@ screen @TRIGGER@ novel nonpeptidomimetic 3cl ( pro ) inhibitors @ARG@ @OSP@

enable @TRIGGER@ interspecies transmission of the various virus gene segments @ARG@ @OSP@

immunological adjuvants @ARG@ enhance @TRIGGER@ poxvirus - based cd8 ( + ) t - cell vaccines @ARG@ @OSP@

hbov - 1 @ARG@ related @TRIGGER@ ari @ARG@ @OSP@ hbov - 1 @ARG@ role @TRIGGER@ this virus @ARG@ @OSP@

membrane @ARG@ promote @TRIGGER@ association of adsorbed subunits @ARG@ @OSP@ thermodynamic and kinetic effects @ARG@ inhibit @TRIGGER@ complete assembly @ARG@ @OSP@

civets @ARG@ role @TRIGGER@ sars - cov transmission @ARG@ @OSP@

assay @ARG@ against @TRIGGER@ 1, 280 compounds identified as potentially active trigger * @ARG@ @OSP@

reverse genetic approach @ARG@ assess @TRIGGER@ importance of these macrodomains @ARG@ @OSP@

hku4 [UNK] cov 3cl ( pro ) @ARG@ identification @TRIGGER@ mers [UNK] cov 3cl ( pro ) enzyme inhibitors @ARG@ @OSP@

roles @ARG@ mediated @TRIGGER@ multivalent interactions of glycans with their cognate proteins @ARG@ @OSP@ glycan - binding proteins @ARG@ mediated @TRIGGER@ lectins @ARG@ @OSP@

histophilus somni @ARG@ causes @TRIGGER@ respiratory, reproductive, cardiac and neuronal diseases in cattle @ARG@ @OSP@

elisa @ARG@ test @TRIGGER@ presence of antibodies to crcov in canine serum samples @ARG@ @OSP@ elisa @ARG@ identified @TRIGGER@ seropositive dogs @ARG@ @OSP@

interplay @TRIGGER@ host – pathogen interactions @ARG@ role @TRIGGER@ host – pathogen interactions @ARG@ @OSP@ interplay @TRIGGER@ lipid species @ARG@ generation @TRIGGER@ novel therapeutic drugs @ARG@ @OSP@

oligochromatographic assay @ARG@ detection @TRIGGER@ 2009 influenza a h1n1 virus @ARG@ @OSP@

multi - domain non - structural protein 3 of sars - coronavirus @ARG@ component @TRIGGER@ viral replication / transcription complex ( rtc ) @ARG@ @OSP@

appearance of vesicular nsp4 - egfp @ARG@ dependent @TRIGGER@ intracellular calcium levels @ARG@ @OSP@ vesicular nsp4 - egfp @ARG@ colocalized @TRIGGER@ autophagosomal marker lc3 @ARG@ @OSP@

correlate @TRIGGER@ diagnostic real - time pcr results @ARG@ correlate @TRIGGER@ histopathologic lesions in cats with clinical signs of upper respiratory infection ( uri ) @ARG@ @OSP@

validation tools @ARG@ evaluate @TRIGGER@ quality of available experimental structures @ARG@ @OSP@ select @TRIGGER@ protein model @ARG@ @OSP@

assembly and budding @ARG@ depend @TRIGGER@ membrane deformation @ARG@ @OSP@ assembly and budding @ARG@ depend @TRIGGER@ association @ARG@ @OSP@

zikv @ARG@ causes @TRIGGER@ microcephally in the babies of mothers infected during pregnancy @ARG@ @OSP@

analytical sensitivity of the new assay @ARG@ measured @TRIGGER@ serial dilutions of a plasmid that contained the target sequence @ARG@ @OSP@

diagnostic assays @ARG@ detection @TRIGGER@ pedv infection @ARG@ @OSP@

pharmacophore models @ARG@ needed @TRIGGER@ ligand recognition @ARG@ @OSP@ binding [UNK] pocket regions @ARG@ involved @TRIGGER@ 3cl ( pro ) [UNK] ligand interactions @ARG@ @OSP@

cargoes @ARG@ modulate @TRIGGER@ autophagy @ARG@ @OSP@ organelles @ARG@ incorporated @TRIGGER@ autophagosomes @ARG@ @OSP@

pathogens @ARG@ escape @TRIGGER@ immune system of the host organism @ARG@ @OSP@ complexity of the lipidome @ARG@ allow @TRIGGER@ survival and replication @ARG@ @OSP@

validation of protein structures @ARG@ detect @TRIGGER@ structural flaws @ARG@ @OSP@ validation of protein structures @ARG@ guide @TRIGGER@ efforts in further refinement @ARG@ @OSP@

frameshifting @ARG@ removing @TRIGGER@ ribosomes from the message @ARG@ @OSP@ frameshifting @ARG@ downregulate @TRIGGER@ synthesis of the 3 ′ - encoded replication proteins @ARG@ @OSP@

cd8 ( + ) and arg ( + ) splenic dcs @ARG@ susceptible @TRIGGER@ infection with mhv - jhm directly ex vivo @ARG@ @OSP@

phenylsulfonamide fragment @ARG@ inhibitory @TRIGGER@ mers [UNK] cov 3cl ( pro ) @ARG@ @OSP@

viruses @ARG@ exclude @TRIGGER@ host proteins and organelles @ARG@ @OSP@ perinuclear or cytoplasmic foci @ARG@ recruit @TRIGGER@ cell organelles @ARG@ @OSP@

crcov @ARG@ role @TRIGGER@ canine infectious respiratory disease ( cird ) @ARG@ @OSP@ crcov @ARG@ predisposing @TRIGGER@ further and potentially more serious viral and bacterial infections @ARG@ @OSP@

@ @TRIGGER@ partial duplication of the membrane gene @ARG@ resulting @TRIGGER@ insertion of a new sequence in gene 8a @ARG@ @OSP@

h. somni @ARG@ causes @TRIGGER@ extracellular trap production by bovine neutrophils @ARG@ @OSP@

fusion protein @ARG@ expressed @TRIGGER@ enhanced green fluorescent protein ( egfp ) @ARG@ @OSP@

prf @ARG@ stimulated @TRIGGER@ rna structure beginning 5 to 9 nucleotides ( nt ) downstream of the slippery site @ARG@ @OSP@

tlr3 - signalling pathways @ARG@ protective @TRIGGER@ tlr3 @ARG@ @OSP@ endogenous and virus - induced negative regulators of the tlr3 cascade @ARG@ pathogenic @ARG@ viral pathogenesis @ARG@ @OSP@

m and c proteins of the zikv shell @ARG@ using @TRIGGER@ disorder predictor pondr vlxt @ARG@ @OSP@

role @TRIGGER@ host cell surface glycan receptors @ARG@ viral pathogenesis @ARG@ @OSP@ viral surface glycans @ARG@ target @TRIGGER@ glycan – gbp interactions @ARG@ @OSP@

viral rna - dependent polymerase structure @ARG@ involved @TRIGGER@ replicating @TRIGGER@ @OSP@ biochemistry and biophysics @ARG@ involved @TRIGGER@ genetic material of rna viruses @ARG@ @OSP@

sars patients with progressive disease after ribavirin treatment @ARG@ given @TRIGGER@ convalescent plasma @ARG@ @OSP@ pulsed methylprednisolone @ARG@ given @TRIGGER@ pulsed methylprednisolone @ARG@ @OSP@

utilize @TRIGGER@ programmed −1 1 ribosomal frameshifting ( [UNK] 1 prf ) @ARG@ produce @TRIGGER@ protein products at a defined ratio @ARG@ @OSP@ translate @TRIGGER@ overlapping orfs @ARG@ increase @TRIGGER@ coding capacity @ARG@ @OSP@

throat bacterial culture @ARG@ throat bacterial culture @ARG@ @OSP@ throat bacterial culture @ARG@ procalcitonin @ARG@ @OSP@ procalciton count @ARG@ bandemia @ARG@ @OSP@

alanine replacement of charged amino - acid residues of the sud - m domain @ARG@ involved @TRIGGER@ g - quadruplex - binding @ARG@ @OSP@ g - quadruplex - binding @ARG@ caused @TRIGGER@ abrogation of rtc activity @ARG@ @OSP@

microarray analysis @ARG@ tgf - [UNK] beta [UNK] @ARG@ @OSP@ tgf - [UNK] beta [UNK] @ARG@ il - 6 up - regulation in whole blood of ards patients @ARG@ @OSP@

role @TRIGGER@ glycan – gbp interactions @ARG@ viral pathogenesis @ARG@ @OSP@ target @TRIGGER@ glycan – gbp interactions @ARG@ antiviral therapeutic or vaccine strategies @ARG@ @OSP@

pathogens @ARG@ target @TRIGGER@ release of polyunsaturated fatty acids from the host cell lipidome @ARG@ @OSP@ pathogens @ARG@ generation @TRIGGER@ eicosanoids @ARG@ @OSP@

civets @ARG@ inoculated @TRIGGER@ human isolates of sars - cov @ARG@ @OSP@ civets @ARG@ inoculated @TRIGGER@ gz01 @ARG@ @OSP@

drugs @ARG@ role @TRIGGER@ quinine analogues @ARG@ @OSP@ angiotensin - converting enzyme inhibitors @ARG@ role @TRIGGER@ angiotensin - converting enzyme inhibitors @ARG@ @OSP@

inhibition of nsp4 expression @ARG@ leads @TRIGGER@ alteration of the production and distribution of other viral proteins and mrna synthesis @ARG@ @OSP@ nsp4 @ARG@ affects @TRIGGER@ virus replication @ARG@ @OSP@

transmission dynamics of covid - 19 @ARG@ interactions @TRIGGER@ exogenous factors @ARG@ @OSP@ interactions @TRIGGER@ exogenous factors @ARG@ false detection problems @ARG@ @OSP@

antibodies, crcov to crcov, crcov, crcov, h. w., brownlie, j., brownlie, j., brownlie, j., brownlie, j., brownlie, j., brownlie, j., brownlie, j., brownlie, j., brownlie, j., brownlie, j., brownlie, j.,

rapid crp / mxa immunoassay @ARG@ identify @TRIGGER@ clinically significant bacterial infection with host response and acute pathogenic viral infection @ARG@ @OSP@

computational vaccine design tools @ARG@ engineer @TRIGGER@ vaccines @ARG@ @OSP@ vaccines @ARG@ for @TRIGGER@ novel emerging pathogen @ARG@ @OSP@ rapid production technologies @ARG@ for @TRIGGER@ wmd biowarfare agent countermeasures @ARG@ @OSP@

nsp4 @ARG@ colocalized @TRIGGER@ lc3 in cap - like structures associated with viroplasms, the site of nascent viral rna replication @ARG@ @OSP@ nsp4 @ARG@ involvement @TRIGGER@ virus replication @ARG@ @OSP@

mutations and deletions within the coding region of the mhv - 1 he gene @ARG@ generated @TRIGGER@ stretch of sequence @ARG@ @OSP@ stretch of sequence @ARG@ initiate @TRIGGER@ synthesis of a novel smaller mrna @ARG@ @OSP@

therapy @TRIGGER@ herpesvirus ( hsv, vzv, cmv ) @ARG@ @OSP@ hepadnavirus ( hbv ) @ARG@ hepacivirus ( hcv ) @ARG@ @OSP@

frozen rsv - infected cells @ARG@ source @TRIGGER@ infectious material @ARG@ @OSP@ cell - based high - throughput screening assay @ARG@ screen @TRIGGER@ inhibitors of rsv - induced cytopathic effect @ARG@ @OSP@

isolation @TRIGGER@ ibdv genomic rna from bursa and spleen tissue specimens @ARG@ @OSP@ dot blot hybridization assay @ARG@ detect @TRIGGER@ ibdv strains in tissue samples from experimentally infected and commercially reared chickens @ARG@ @OSP@

t - cell immunological studies of sars - cov @ARG@ against @TRIGGER@ mers - cov @ARG@ @OSP@

@ @TRIGGER@ −1 prf in theiler's murineomyelitis virus ( tmev ) @ARG@ dependent @TRIGGER@ stem - loop structure @ARG@ @OSP@

assays @ARG@ detect @TRIGGER@ infection of pigs at a herd level @ARG@ @OSP@ assays @ARG@ by @TRIGGER@ recently circulating strains ( indel and non - indel ) @ARG@ @OSP@

reproduction number, r, defined as the average number of secondary cases generated by a primary case, is a crucial quantity for trigger @TRIGGER@ reproduction number, r, defined as the average number of secondary cases generated by a primary case, is a crucial quantity for trigger @TRIGGER@ intensity of interventions @ARG@ required @TRIGGER@ control an epidemic @ARG@ @OSP@

carboxy - terminal six amino acids of the cytoplasmic domain of the alpha chain @ARG@ constraining @TRIGGER@ translational diffusion of i - ak molecules in the plasma membrane @ARG@ @OSP@

predicted 3 ′ rna stem - loop structure at a noncanonical structure at a noncanonical structure at a noncanonical structure at a noncanonical structure at a noncanonical structure at a noncanonical structure at a noncanonical structure at a noncanonical structure at a noncanonical structure at a noncanonical structure at a noncanonical structure at a noncanonical structure at a noncano

( 13 ) c ( [UNK] ) nuclei @ARG@ determination @TRIGGER@ protein structures @ARG@ @OSP@ ( 13 ) c ( [UNK] ) nuclei @ARG@ validation @TRIGGER@ protein structures @ARG@ @OSP@

full - length e protein @ARG@ incorporated @TRIGGER@ novel chimeric protein with a pbm @ARG@ @OSP@ pdz - binding motif ( pbm ) @ARG@ restored @TRIGGER@ sequence of the pbm on the e protein @ARG@ @OSP@

nsp4 - egfp4 - egfp4 - egfp4 - egfp did enter of an nsp4 - egfp4 - egfp did enter of an nsp4 - egfp4 - egfp did enter the nsp4 - egfp4 - egfp did enter the nsp4 - egfp did enter the nsp4 - egfp did enter the nsp4 - egfp did enter from nsp4 - egfp did enter from nsp4 - egfp did enter from nsp4 - egfp did enter from nsp4 - egfp did enter

x domain @ARG@ binds @TRIGGER@ adp - ribose - 1 ” - phosphatase @ARG@ @OSP@ poly ( adp - ribose ) - binding protein @ARG@ binds @TRIGGER@ oligo ( g ) - nucleotides @ARG@ @OSP@ sud - nm @ARG@ forming @TRIGGER@ g - quadruplexes @ARG@ @OSP@

) @ARG@ key @TRIGGER@ dcs @ARG@ @OSP@ infection of these cells @ARG@ infected @TRIGGER@ dysregulated immune response @ARG@ @OSP@

quantitative reverse transcription real time polymerase chain reactions ( rt real time qt - pcrs ) @ARG@ detection @TRIGGER@ hpiv - 1, - 2 and - 3 in clinical samples @ARG@ @OSP@ indirect immunofluorescence ( ifa ) @ARG@ quantitation @TRIGGER@ hpiv - 1, - 2 and - 3 in clinical samples @ARG@ @OSP@

complex glycans @ARG@ roles @TRIGGER@ dynamic interplay between the virus and the host @ARG@ @OSP@ viral entry into host cell @ARG@ modulation of proteolytic cleavage of viral proteins @ARG@ @OSP@ recognition and neutralization of virus @ARG@ by @TRIGGER@ host immune system @ARG@ @OSP@

role @TRIGGER@ cofactors @ARG@ favoring @TRIGGER@ onset of the disease @ARG@ @OSP@ genetic factors @ARG@ inhibiting @TRIGGER@ environmental factors @ARG@ @OSP@ environmental factors @ARG@ modulating @TRIGGER@ lymph flow disorders @ARG@ @OSP@

poxvirus vectors ( vaccinia wr and canarypox ) expressing only the fipv membrane ( m ) protein @ARG@ elicit @TRIGGER@ partially protective immunity @ARG@ @OSP@

arg * induce * trigger * lipid metabolites at the host cell level @ARG@ induce * alterations in lipid metabolites at the host cell level @ARG@ @OSP@ arg * eukaryotic pathogens * arg focus on arg, arg @TRIGGER@ interference with lipid metabolites @ARG@ interference with lipid metabolites @ARG@ @OSP@ eukaryotic pathogens @ARG@ affecting @TRIGGER@ systemic inflammatory reactions @ARG@ @OSP@

molecular clone @ARG@ representing @TRIGGER@ 445 base pairs at the 3'end of infectious bursal disease virus ( ibdv ) genome segment b @ARG@ @OSP@ dot blot hybridization assay @ARG@ detect @TRIGGER@ viral rna from cell culture and from chicken bursa and spleen tissue specimens @ARG@ @OSP@

risk of a new influenza pandemic @ARG@ promote @TRIGGER@ repeated interspecies transmission events @ARG@ @OSP@ repeated interspecies transmission events @ARG@ facilitate @TRIGGER@ reassortment between animal influenza strains @ARG@ @OSP@ barrier @TRIGGER@ cross [UNK] species transmission of influenza a viruses ( iavs ) @ARG@ @OSP@

tested @TRIGGER@ feline herpesvirus type 1 ( fhv - 1 ) @ARG@ tested @TRIGGER@ quantitative real - time pcr ( qpcr ) @ARG@ @OSP@ feline calicivirus ( fcv ) @ARG@ tested @TRIGGER@ mycoplasma felis @ARG@ @OSP@ feline calicivirus ( fcv ) @ARG@ bordetella bronchiseptica @ARG@ @OSP@

hadv - 3 mutant @ARG@ encoding @TRIGGER@ small epitope tags at the n - termini of both e3 - cr1 [UNK] and e3 - cr1 [UNK] @ARG@ @OSP@ double knock out ( hadv - 3 n - tag dko ) mutant virus @ARG@ encoding @TRIGGER@ double knock out ( hadv - 3 n - tag dko ) mutant virus @ARG@ @OSP@

inhaled bronchodilators @ARG@ reduce @TRIGGER@ likelihood of treatment failures @ARG@ @OSP@ supplemental oxygen @ARG@ reduce @TRIGGER@ antibiotics @ARG@ @OSP@ non - invasive positive - pressure ventilation @ARG@ speed @TRIGGER@ acute ventilatory failure @ARG@ @OSP@

monocyte count @ARG@ associated @TRIGGER@ whole lung involvement @ARG@ @OSP@ confusion @ARG@ associated @TRIGGER@ whole lung involvement @ARG@ @OSP@ early cidofovir treatment @ARG@ associated @TRIGGER@ respiratory failure @ARG@ @OSP@

antibody @ARG@ transferred @TRIGGER@ colostrum @ARG@ @OSP@ pups @ARG@ capable @TRIGGER@ absorption @ARG@ @OSP@

public education campaign @ARG@ educate @TRIGGER@ singaporeans on sars and adoption of appropriate behaviours to prevent the spread of the disease @ARG@ @OSP@

pharmacophore modeling study @ARG@ supported @TRIGGER@ in vitro validation @ARG@ @OSP@

3d queries @ARG@ screen @TRIGGER@ national cancer institute database @ARG@ @OSP@

molecular factors @ARG@ enable @TRIGGER@ interspecies transmission of the various virus gene segments @ARG@ @OSP@

immunological adjuvants @ARG@ enhance @TRIGGER@ poxvirus - based cd8 ( + ) t - cell vaccines @ARG@ @OSP@

this particular genotype @ARG@ related @TRIGGER@ ari @ARG@ @OSP@ this particular genotype @ARG@ related @TRIGGER@ ari @ARG@ @OSP@ role @TRIGGER@ this virus @ARG@ aetiology of respiratory diseases @ARG@ @OSP@ hbov - 1 @ARG@ role @TRIGGER@ aetiology of respiratory diseases @ARG@ @OSP@

the membrane @ARG@ promote @TRIGGER@ association of adsorbed subunits @ARG@ @OSP@ association of adsorbed subunits @ARG@ through @TRIGGER@ dimensional reduction @ARG@ @OSP@ the membrane @ARG@ introduces @TRIGGER@ thermodynamic and kinetic effects @ARG@ @OSP@ it @ARG@ introduces @TRIGGER@ thermodynamic and kinetic effects @ARG@ @OSP@ thermodynamic and kinetic effects @ARG@ inhibit @TRIGGER@ complete assembly @ARG@ @OSP@

civets @ARG@ role @TRIGGER@ sars - cov transmission @ARG@ @OSP@ masked palm civets ( paguma larvata ) @ARG@ role @TRIGGER@ sars - cov transmission @ARG@ @OSP@

compounds @ARG@ against @TRIGGER@ rsv ( long strain ) @ARG@ @OSP@

reverse genetic approach @ARG@ assess @TRIGGER@ importance of these macrodomains for the activity of the sars - cov rtc @ARG@ @OSP@

hku4 ‐ cov 3cl ( pro ) @ARG@ identification @TRIGGER@ mers ‐ cov 3cl ( pro ) enzyme inhibitors @ARG@ @OSP@

interactions @TRIGGER@ glycans @ARG@ cognate proteins @ARG@ @OSP@ interactions @TRIGGER@ glycans @ARG@ glycan - binding proteins @ARG@ @OSP@ interactions @TRIGGER@ glycans @ARG@ gbps @ARG@ @OSP@ interactions @TRIGGER@ glycans @ARG@ lectins @ARG@ @OSP@

histophilus somni @ARG@ causes @TRIGGER@ respiratory, reproductive, cardiac and neuronal diseases in cattle @ARG@ @OSP@ haemophilus somnus @ARG@ causes @TRIGGER@ respiratory, reproductive, cardiac and neuronal diseases in cattle @ARG@ @OSP@ gram - negative pleomorphic coccobacillus @ARG@ causes @TRIGGER@ respiratory, reproductive, cardiac and neuronal diseases in cattle @ARG@ @OSP@

elisa @ARG@ identified @TRIGGER@ seropositive dogs @ARG@ @OSP@ elisa @ARG@ test @TRIGGER@ presence of antibodies to crcov in canine serum samples @ARG@ @OSP@

role @TRIGGER@ lipid species @ARG@ cellular physiology @ARG@ @OSP@ interplay between host – pathogen interactions @ARG@ generation @TRIGGER@ novel therapeutic drugs @ARG@ @OSP@

speed - oligo novel influenza a h1n1 @ARG@ detection @TRIGGER@ 2009 influenza a h1n1 virus @ARG@ @OSP@ oligochromatographic assay @ARG@ detection @TRIGGER@ 2009 influenza a h1n1 virus @ARG@ @OSP@

multi - domain non - structural protein 3 of sars - coronavirus @ARG@ component @TRIGGER@ viral replication / transcription complex ( rtc ) @ARG@ @OSP@

vesicular nsp4 - egfp @ARG@ colocalized @TRIGGER@ autophagosomal marker lc3 @ARG@ @OSP@ vesicular nsp4 - egfp @ARG@ dependent @TRIGGER@ intracellular calcium levels @ARG@ @OSP@

correlate @TRIGGER@ diagnostic real - time pcr results @ARG@ histopathologic lesions in cats with clinical signs of upper respiratory infection ( uri ) @ARG@ @OSP@

accurate and efficient validation tools @ARG@ evaluate @TRIGGER@ quality of available experimental structures @ARG@ @OSP@ molecular biologists @ARG@ evaluate @TRIGGER@ quality of available experimental structures @ARG@ @OSP@ computational chemists @ARG@ evaluate @TRIGGER@ quality of available experimental structures @ARG@ @OSP@ accurate and efficient validation tools @ARG@ select @TRIGGER@ protein model which is the most suitable @ARG@ @OSP@ molecular biologists @ARG@ select @TRIGGER@ protein model which is the most suitable @ARG@ @OSP@ computational chemists @ARG@ select @TRIGGER@ protein model which is the most suitable @ARG@ @OSP@

assembly and budding @ARG@ depend @TRIGGER@ system dynamics @ARG@ @OSP@ assembly and budding @ARG@ via @TRIGGER@ multiple timescales related to membrane deformation @ARG@ @OSP@ assembly and budding @ARG@ via @TRIGGER@ protein diffusion, association, and adsorption onto the membrane @ARG@ @OSP@

zikv @ARG@ causes @TRIGGER@ microcephaly in the babies of mothers infected during pregnancy @ARG@ @OSP@

analytical sensitivity of the new assay @ARG@ measured @TRIGGER@ serial dilutions of a plasmid that contained the target sequence @ARG@ @OSP@

diagnostic assays @ARG@ detection @TRIGGER@ pedv infection @ARG@ @OSP@

structural features @ARG@ needed @TRIGGER@ ligand recognition @ARG@ @OSP@ binding ‐ pocket regions @ARG@ involved @TRIGGER@ 3cl ( pro ) ‐ ligand interactions @ARG@ @OSP@

cells @ARG@ modulate @TRIGGER@ autophagy @ARG@ @OSP@ cargoes @ARG@ incorporated @TRIGGER@ autophagosomes @ARG@ @OSP@ organelles @ARG@ incorporated @TRIGGER@ autophagosomes @ARG@ @OSP@ aberrant protein aggregates @ARG@ incorporated @TRIGGER@ autophagosomes @ARG@ @OSP@ bacteria @ARG@ incorporated @TRIGGER@ autophagosomes @ARG@ @OSP@

pathogens @ARG@ evolved @TRIGGER@ take advantage of the complexity of the lipidome @ARG@ @OSP@ take advantage of the complexity of the lipidome @ARG@ escape @TRIGGER@ immune system of the host organism @ARG@ @OSP@ pathogens @ARG@ escape @TRIGGER@ immune system of the host organism @ARG@ @OSP@ take advantage of the complexity of the lipidome @ARG@ allow @TRIGGER@ survival @ARG@ @OSP@ take advantage of the complexity of the lipidome @ARG@ allow @TRIGGER@ replication @ARG@ @OSP@ pathogens @ARG@ allow @TRIGGER@ survival @ARG@ @OSP@ pathogens @ARG@ allow @TRIGGER@ replication @ARG@ @OSP@

spectroscopists @ARG@ detect @TRIGGER@ structural flaws @ARG@ @OSP@

tmev @ARG@ evolved @TRIGGER@ frameshifting @ARG@ @OSP@ frameshifting @ARG@ downregulate @TRIGGER@ synthesis of the 3 ′ - encoded replication proteins @ARG@ @OSP@ frameshifting @ARG@ removing @TRIGGER@ ribosomes from the message ( a “ ribosome sink ” ) @ARG@ @OSP@

cd8 ( + ) and cd11b ( + ) splenic dcs @ARG@ susceptible @TRIGGER@ infection with mhv - jhm @ARG@ @OSP@

inhibitory activity @ARG@ against @TRIGGER@ mers ‐ cov 3cl ( pro ) @ARG@ @OSP@ two hits @ARG@ development @TRIGGER@ novel anti ‐ mers agents @ARG@ @OSP@

perinuclear or cytoplasmic foci @ARG@ recruit @TRIGGER@ cell organelles @ARG@ @OSP@

crcov @ARG@ role @TRIGGER@ canine infectious respiratory disease ( cird ) @ARG@ @OSP@

mutant virus regained fitness @ARG@ after @TRIGGER@ serial passages in cell culture or in vivo @ARG@ @OSP@ mutant virus regained fitness @ARG@ resulting @TRIGGER@ partial duplication of the membrane gene @ARG@ @OSP@ mutant virus regained fitness @ARG@ resulting @TRIGGER@ insertion of a new sequence in gene 8a @ARG@ @OSP@

h. somni @ARG@ causes @TRIGGER@ extracellular trap production @ARG@ @OSP@ causes @TRIGGER@ extracellular trap production @ARG@ bovine neutrophils @ARG@ @OSP@

fused @TRIGGER@ c terminus of full - length nsp4 @ARG@ enhanced green fluorescent protein ( egfp ) @ARG@ @OSP@ hek 293 - based cell line @ARG@ avoid @TRIGGER@ possible cytotoxicity @ARG@ @OSP@

−1 prf @ARG@ stimulated @TRIGGER@ rna structure beginning 5 to 9 nucleotides ( nt ) @ARG@ @OSP@

tlr3 - signalling pathways @ARG@ regulators @TRIGGER@ tlr3 cascade @ARG@ @OSP@

examination of the m and c proteins of the zikv shell @ARG@ using @TRIGGER@ disorder predictor pondr vlxt @ARG@ @OSP@

role @TRIGGER@ host cell surface glycan receptors @ARG@ viral pathogenesis @ARG@ @OSP@ role @TRIGGER@ viral surface glycans @ARG@ viral pathogenesis @ARG@ @OSP@ various analytical tools @ARG@ target @TRIGGER@ glycan – gbp interactions @ARG@ @OSP@

viral rna - dependent polymerase structure @ARG@ replicating @TRIGGER@ genetic material of rna viruses @ARG@ @OSP@ viral rna - dependent polymerase structure @ARG@ transcribing @TRIGGER@ genetic material of rna viruses @ARG@ @OSP@

sars patients with progressive disease after ribavirin treatment and 1. 5 g of pulsed methylprednisolone @ARG@ given @TRIGGER@ convalescent plasma @ARG@ @OSP@ sars patients with progressive disease after ribavirin treatment and 1. 5 g of pulsed methylprednisolone @ARG@ given @TRIGGER@ pulsed methylprednisolone @ARG@ @OSP@

viruses @ARG@ produce @TRIGGER@ different protein products at a defined ratio @ARG@ @OSP@ viruses @ARG@ utilize @TRIGGER@ programmed −1 ribosomal frameshifting ( −1 prf ) @ARG@ @OSP@ viruses @ARG@ increase @TRIGGER@ coding capacity @ARG@ @OSP@

classifying @TRIGGER@ uri etiology @ARG@ algorithm @ARG@ @OSP@

alanine replacement of charged amino - acid residues of the sud - m domain @ARG@ caused @TRIGGER@ abrogation of rtc activity @ARG@ @OSP@

microarray analysis @ARG@ employed @TRIGGER@ th17 - like innate immunity - related cytokine @ARG@ @OSP@

tools @ARG@ synthesize @TRIGGER@ glycans @ARG@ @OSP@ tools @ARG@ synthesize @TRIGGER@ glycan – gbp interactions @ARG@ @OSP@ technologies @ARG@ synthesize @TRIGGER@ glycans @ARG@ @OSP@ technologies @ARG@ synthesize @TRIGGER@ glycan – gbp interactions @ARG@ @OSP@

pathogens @ARG@ target @TRIGGER@ release of polyunsaturated fatty acids from the host cell lipidome @ARG@ @OSP@ pathogens @ARG@ generation @TRIGGER@ eicosanoids @ARG@ @OSP@

susceptibility @TRIGGER@ civets @ARG@ infection by different sars - cov isolates @ARG@ @OSP@ civets @ARG@ inoculated @TRIGGER@ human isolates of sars - cov @ARG@ @OSP@ civets @ARG@ inoculated @TRIGGER@ bj01 ( with a 29 - nucleotide deletion ) @ARG@ @OSP@ civets @ARG@ inoculated @TRIGGER@ gz01 ( without the 29 - nucleotide deletion ) @ARG@ @OSP@

ks pathogenesis @ARG@ role @TRIGGER@ drugs @ARG@ @OSP@ role @TRIGGER@ drugs @ARG@ onset of the disease @ARG@ @OSP@ ks pathogenesis @ARG@ role @TRIGGER@ quinine analogues @ARG@ @OSP@ role @TRIGGER@ quinine analogues @ARG@ onset of the disease @ARG@ @OSP@ ks pathogenesis @ARG@ role @TRIGGER@ angiotensin - converting enzyme inhibitors @ARG@ @OSP@ role @TRIGGER@ angiotensin - converting enzyme inhibitors @ARG@ onset of the disease @ARG@ @OSP@

nsp4 @ARG@ affects @TRIGGER@ virus replication @ARG@ @OSP@

transmission dynamics of covid - 19 @ARG@ analyse @TRIGGER@ modelling and dynamical systems techniques @ARG@ @OSP@ examine @TRIGGER@ transmission dynamics of covid - 19 @ARG@ a simple epidemiological model @ARG@ @OSP@

serum antibodies @ARG@ to @TRIGGER@ crcov @ARG@ @OSP@

prospective, multicenter, cross - sectional study of adults and children with febrile upper respiratory tract infections ( uris ) @ARG@ evaluate @TRIGGER@ diagnostic accuracy of a rapid crp / mxa immunoassay @ARG@ @OSP@ diagnostic accuracy of a rapid crp / mxa immunoassay @ARG@ identify @TRIGGER@ bacterial infection with host response and acute pathogenic viral infection @ARG@ @OSP@

vaccines @ARG@ for @TRIGGER@ novel emerging pathogen @ARG@ @OSP@ vaccines @ARG@ for @TRIGGER@ wmd biowarfare agent countermeasures @ARG@ @OSP@ engineer @TRIGGER@ vaccines @ARG@ novel emerging pathogen @ARG@ @OSP@ engineer @TRIGGER@ vaccines @ARG@ wmd biowarfare agent countermeasures @ARG@ @OSP@ apply @TRIGGER@ computational vaccine design tools @ARG@ vaccines @ARG@ @OSP@ apply @TRIGGER@ rapid production technologies @ARG@ vaccines @ARG@ @OSP@

nsp4 @ARG@ colocalized @TRIGGER@ lc3 in cap - like structures @ARG@ @OSP@ lc3 in cap - like structures @ARG@ associated @TRIGGER@ viroplasms @ARG@ @OSP@ viroplasms @ARG@ site @TRIGGER@ viral rna replication @ARG@ @OSP@ involvement @TRIGGER@ nsp4 @ARG@ virus replication @ARG@ @OSP@

mutations and deletions within the coding region of the mhv - 1 he gene @ARG@ generated @TRIGGER@ stretch of sequence which resembled the transcriptional initiation motif @ARG@ @OSP@ stretch of sequence which resembled the transcriptional initiation motif @ARG@ initiate @TRIGGER@ synthesis of a novel smaller mrna @ARG@ @OSP@

others @ARG@ therapy @TRIGGER@ herpesvirus @ARG@ @OSP@ others @ARG@ therapy @TRIGGER@ hsv @ARG@ @OSP@ others @ARG@ therapy @TRIGGER@ vzv @ARG@ @OSP@ others @ARG@ therapy @TRIGGER@ cmv @ARG@ @OSP@ others @ARG@ therapy @TRIGGER@ hepadnavirus ( hbv ) @ARG@ @OSP@ others @ARG@ therapy @TRIGGER@ hepacivirus ( hcv ) @ARG@ @OSP@ others @ARG@ therapy @TRIGGER@ myxovirus ( influenza, rsv ) @ARG@ @OSP@

cell - based high - throughput screening assay @ARG@ screen @TRIGGER@ inhibitors of rsv - induced cytopathic effect @ARG@ @OSP@ frozen rsv - infected cells @ARG@ source @TRIGGER@ infectious material @ARG@ @OSP@

rapid procedure @ARG@ isolation @TRIGGER@ ibdv genomic rna @ARG@ @OSP@ rapid procedure @ARG@ detect @TRIGGER@ ibdv strains in tissue samples @ARG@ @OSP@

broad - spectrum vaccines @ARG@ against @TRIGGER@ coronavirus infections @ARG@ @OSP@ cross - reactivity of the sars - cov - specific immunity @ARG@ against @TRIGGER@ mers - cov @ARG@ @OSP@

−1 prf in theiler's murine encephalomyelitis virus ( tmev ) @ARG@ dependent @TRIGGER@ stem - loop structure @ARG@ @OSP@

each of the assays @ARG@ detect @TRIGGER@ infection of pigs at a herd level @ARG@ @OSP@

r @ARG@ identifying @TRIGGER@ intensity of interventions required to control an epidemic @ARG@ @OSP@

carboxy - terminal six amino acids of the cytoplasmic domain of the alpha chain @ARG@ constraining @TRIGGER@ translational diffusion of i - ak molecules in the plasma membrane @ARG@ @OSP@ plasma membrane - proximal amino acids of the beta chain @ARG@ constraining @TRIGGER@ translational diffusion of i - ak molecules in the plasma membrane @ARG@ @OSP@

3 ′ rna stem - loop structure @ARG@ required @TRIGGER@ efficient frameshifting in tmev @ARG@ @OSP@

computational methods @ARG@ validation @TRIGGER@ protein structures @ARG@ @OSP@ computational methods @ARG@ determination @TRIGGER@ protein structures @ARG@ @OSP@ ( 13 ) c ( α ) chemical shifts @ARG@ use @TRIGGER@ computational methods @ARG@ @OSP@

revertant viruses @ARG@ incorporated @TRIGGER@ novel chimeric protein with a pbm @ARG@ @OSP@ revertant viruses @ARG@ restored @TRIGGER@ sequence of the pbm on the e protein @ARG@ @OSP@

nsp4 - egfp @ARG@ distributed @TRIGGER@ novel vesicular structures throughout the cytoplasm @ARG@ @OSP@ nsp4 - egfp @ARG@ diverging @TRIGGER@ known biosynthetic pathways @ARG@ @OSP@

sud - nm @ARG@ binds @TRIGGER@ oligo ( g ) - nucleotides @ARG@ @OSP@ oligo ( g ) - nucleotides @ARG@ forming @TRIGGER@ g - quadruplexes @ARG@ @OSP@

) @ARG@ initiation @TRIGGER@ innate and adaptive immune responses @ARG@ @OSP@ dcs @ARG@ infected @TRIGGER@ a59 strain ( mhv - a59 ) @ARG@ @OSP@ infection of these cells @ARG@ contribute @TRIGGER@ dysregulated immune response @ARG@ @OSP@

quantitative reverse transcription real time polymerase chain reactions ( rt real time qt - pcrs ) @ARG@ detection @TRIGGER@ hpiv - 1, - 2 and - 3 in clinical samples @ARG@ @OSP@ indirect immunofluorescence ( ifa ) @ARG@ detection @TRIGGER@ hpiv - 1, - 2 and - 3 in clinical samples @ARG@ @OSP@ quantitative reverse transcription real time polymerase chain reactions ( rt real time qt - pcrs ) @ARG@ quantitation @TRIGGER@ hpiv - 1, - 2 and - 3 in clinical samples @ARG@ @OSP@ indirect immunofluorescence ( ifa ) @ARG@ quantitation @TRIGGER@ hpiv - 1, - 2 and - 3 in clinical samples @ARG@ @OSP@

role @TRIGGER@ cofactors @ARG@ ks pathogenesis @ARG@ @OSP@ agents @ARG@ modulating @TRIGGER@ pathogenesis @ARG@ @OSP@ ks pathogenesis @ARG@ agents @ARG@ modulating @TRIGGER@ @OSP@ modulating @TRIGGER@ pathogenesis @ARG@ lymph flow disorders @ARG@ @OSP@ ks pathogenesis @ARG@ modulating @TRIGGER@ lymph flow disorders @ARG@ @OSP@ modulating @TRIGGER@ pathogenesis @ARG@ environmental factors @ARG@ @OSP@ ks pathogenesis @ARG@ modulating @TRIGGER@ environmental factors @ARG@ @OSP@ modulating @TRIGGER@ pathogenesis @ARG@ drug intake @ARG@ @OSP@ ks pathogenesis @ARG@ modulating @TRIGGER@ drug intake @ARG@ @OSP@ modulating @TRIGGER@ pathogenesis @ARG@ genetic predisposition @ARG@ @OSP@ ks pathogenesis @ARG@ modulating @TRIGGER@ genetic predisposition @ARG@ @OSP@

poxvirus vectors ( vaccinia wr and canarypox ) @ARG@ elicit @TRIGGER@ partially protective immunity @ARG@ @OSP@ poxvirus vectors ( vaccinia wr and canarypox ) @ARG@ expressing @TRIGGER@ fipv membrane ( m ) protein @ARG@ @OSP@

viruses @ARG@ alterations @TRIGGER@ lipid metabolites at the host cell level @ARG@ @OSP@ bacteria @ARG@ alterations @TRIGGER@ lipid metabolites at the host cell level @ARG@ @OSP@ eukaryotic pathogens @ARG@ interference @TRIGGER@ lipid metabolites affecting systemic inflammatory reactions @ARG@ @OSP@

molecular clone representing 445 base pairs at the 3'end of infectious bursal disease virus ( ibdv ) genome segment b @ARG@ used @TRIGGER@ dot blot hybridization assay @ARG@ @OSP@

risk of a new influenza pandemic @ARG@ increases @TRIGGER@ repeated interspecies transmission events @ARG@ @OSP@ repeated interspecies transmission events @ARG@ facilitate @TRIGGER@ reassortment between animal influenza strains @ARG@ @OSP@

conjunctival and oropharyngeal swab specimens @ARG@ tested @TRIGGER@ quantitative real - time pcr ( qpcr ) @ARG@ @OSP@ quantitative real - time pcr ( qpcr ) @ARG@ for @TRIGGER@ feline herpesvirus type 1 ( fhv - 1 ) @ARG@ @OSP@ quantitative real - time pcr ( qpcr ) @ARG@ for @TRIGGER@ feline calicivirus ( fcv ) @ARG@ @OSP@ quantitative real - time pcr ( qpcr ) @ARG@ for @TRIGGER@ mycoplasma felis @ARG@ @OSP@ quantitative real - time pcr ( qpcr ) @ARG@ for @TRIGGER@ chlamydophila felis @ARG@ @OSP@ quantitative real - time pcr ( qpcr ) @ARG@ for @TRIGGER@ bordetella bronchiseptica @ARG@ @OSP@

hadv - 3 mutant @ARG@ encoding @TRIGGER@ small epitope tags at the n - termini of both e3 - cr1β and e3 - cr1γ ( hadv - 3 n - tag wt ) @ARG@ @OSP@

inhaled bronchodilators @ARG@ improve @TRIGGER@ airway obstruction @ARG@ @OSP@ supplemental oxygen @ARG@ improve @TRIGGER@ airway obstruction @ARG@ @OSP@ careful clinical assessment @ARG@ improve @TRIGGER@ airway obstruction @ARG@ @OSP@ corticosteroids @ARG@ decrease @TRIGGER@ treatment failures @ARG@ @OSP@ corticosteroids @ARG@ speed @TRIGGER@ recovery @ARG@ @OSP@ non - invasive positive - pressure ventilation @ARG@ treatment @TRIGGER@ acute ventilatory failure @ARG@ @OSP@

early cidofovir treatment @ARG@ associated @TRIGGER@ respiratory failure @ARG@ @OSP@ confusion @ARG@ associated @TRIGGER@ respiratory failure @ARG@ @OSP@ monocyte count @ARG@ associated @TRIGGER@ respiratory failure @ARG@ @OSP@ early cidofovir treatment @ARG@ associated @TRIGGER@ respiratory failure @ARG@ @OSP@ confusion @ARG@ associated @TRIGGER@ respiratory failure @ARG@ @OSP@ monocyte count @ARG@ associated @TRIGGER@ respiratory failure @ARG@ @OSP@