serious: 1 patientsex: 2 drugs: ALENDRONATE SODIUM, AMITRIPTYLINE, CELECOXIB, GLIMEPIRIDE, HYDROXYZINE PALMITATE, NIACIN, PAROXETINE, SIMVASTATIN reactions: Drug interaction, Memory impairment serious: 1 patientsex: 2 drugs: AMLODIPINE BESYLATE, LISINOPRIL reactions: Intentional overdose, Metabolic acidosis, Shock serious: 1 patientsex: 1 drugs: HYDROXOCOBALAMIN reactions: Blood chromaturia, Red urine serious: 1 patientsex: 1 drugs: AZATHIOPRINE, INFLIXIMAB, MESALAMINE, PREDNISOLONE reactions: Acute respiratory failure, Interstitial lung disease serious: 1 patientsex: 2 drugs: BEVACIZUMAB, CYCLOPHOSPHAMIDE, EPIRUBICIN, PACLITAXEL reactions: Cardiac failure, Cardiac thrombosis, Cardiomegaly, Bundle branch block right, Dyspnoea exertional, Left ventricular hypertrophy, Left atrial thrombosis, Left ventricular dysfunction, Sinus tachycardia, Sinus thrombosis, Sinus thorax, Ventricular hypertrophy serious: 1 patientsex: 1 drugs: CEFTAROLINE HYDROCHLORIDE reactions: Neutropenia serious: 1 patientsex: 1 drugs: CEFTAZIDIME, FOSCARNET, GANCICLOVIR, VANCOMYCIN reactions: Leukocytoclastic vasculitis, Off label use, Renal impairment serious: 1 patientsex: 1 drugs: HYDROXYUREA, IMATINIB reactions: Blast stage leukaemia serious: 1 patientsex: 1 drugs: FLUOROURACIL, LEUCOVORIN, OXALIPLATIN, PANITUMUMAB reactions: Electrolyte imbalance, Skin toxicity serious: 1 patientsex: 2 drugs: BEVACIZUMAB, CARBOPLATIN, DOCETAXEL, DOXORUBICIN, TRASTUZUMAB reactions: Cardiac failure congestive serious: 1 patientsex: 2 drugs: CAPECITABINE, EVEROLIMUS, EXEMESTANE, PACLITAXEL, GEMCITABINEGEMCITABINE HYDROCHLORIDE reactions: Multiple organ dysfunction syndrome, Septic shock serious: 1 patientsex: 2 drugs: FACTOR IX, WARFARIN reactions: Acute myocardial infarction, Ischaemic stroke serious: 1 patientsex: 1 drugs: AMLODIPINE BESYLATE reactions: Acute kidney injury, Hypercalcaemia, Splenic large B-cell lymphoma serious: 1 patientsex: 2 drugs: DOBUTAMINEDOBUTAMINE HYDROCHLORIDE, MITOMYCIN, OCTREOTIDE reactions: Cardiogenic shock, Drug interaction, Drug level increased, Pulmonary oedema, Respiratory failure, Shock serious: 1 patientsex: 2 drugs: NAPROXEN reactions: Acute hepatic failure, Eosinophilic pneumonia serious: 1 patientsex: 1 drugs: METHYLPREDNISOLONE, SIROLIMUS reactions: Anasarca, Acidosis, Drug level above therapeutic, Fluid overload, Hypoventricle dilatation, Mitral valve incompetence, Occipital haematoma, Periventricular enlargement, Thrombocytopenia serious: 1 patientsex: 1 drugs: ABACAVIR, LAMIVUDINE, LOPINAVIRRITONAVIR reactions: Acute necrotising ulcerative gingivitis serious: 1 patientsex: 2 drugs: INFLIXIMAB, METHOTREXATE reactions: Histoplasmosis disseminated, Jaundice cholestatic, Pleural effusion serious: 1 patientsex: 2 drugs: AMLODIPINE BESYLATE, FLUDROCORTISONE reactions: Blood creatinine increased, Hyperkalaemia serious: 1 patientsex: 2 drugs: ATROPINE, BOSENTAN, SILDENAFIL reactions: Drug ineffective, Hypertrophic pyloric stenosis serious: 1 patientsex: 2 drugs: VALPROIC ACID reactions: Intentional overdose, Suicide attempt, Toxicity to various agents serious: 1 patientsex: 1 drugs: BUPIVACAINE, EPINEPHRINE, METHYLPREDNISOLONE reactions: Hypokalaemia serious: 1 patientsex: 2 drugs: CARBAMAZEPINE, CLOBAZAM, CLONAZEPAM, ETOPOSIDE, GABAPENTIN, LACOSAMIDE, LEVETIRACETAM, NITROFURANTOIN, PIGAPENTIN, TOPIRAMATE, VALPROIC ACID reactions: Status epilepticus serious: 1 patientsex: 1 drugs: ETHAMBUTOL HYDROCHLORIDE, ISONIAZID, MEROPENEM, MINOCYCLINEMINOCYCLINE HYDROCHLORIDE, PREDNISOLONE, RIFAMPIN reactions: Histoplasmosis disseminated serious: 1 patientsex: 2 drugs: LEVOTHYROXINE, METHIMAZOLE reactions: Gastroschisis, Foetal exposure during pregnancy, Premature baby serious: 1 patientsex: 1 drugs: ASPIRIN reactions: Peptic ulcer serious: 1 patientsex: 2 drugs: BEVACIZUMAB, RANIBIZUMAB reactions: Retinal pigment epithelial atrophy serious: 1 patientsex: 1 drugs: LITHIUM reactions: Hypercalcaemia serious: 1 patientsex: 2 drugs: CYCLOPHOSPHAMIDE, DOXORUBICIN reactions: Acute promyelocytic leukaemia serious: 1 patientsex: 2 drugs: ANAKINRA, ABATACEPT, ANAKINRA-LAPINE T-LYMPHOCYTE IMMUNE GLOBULIN, ANAKINRA-SODIUM PHOSPHATE, ABATACEPT, ANAKINRA-SODIUM PHOSPHATE, ABATACEPT, ANAKINRA-SODIUM PHOSPHATE, ABATACEPT, ANAKINRA-SODIUM PHOSPHATE, ABATACEPT, ABATACEPT, ABATACEPT, ABATACEPT, ABATACEPT, ABATACEPT, ABATACEPT, ABATACEPT, ABATACEPT, ABATACEPT, ABATACEPT, ABATACEPT, ABATACEPT, ABATACEPT, ABATACEPT, ABATACEPT, ABATACEPT, ABATACEPT, ABATACEPT, ABATACEPT, ABATACEPT, ABATACEPT, ABATACEPT, ABATACEPT, ABATACEPT, ABATACEPT, ABA serious: 1 patientsex: 2 drugs: DEXTROSE reactions: Endophthalmitis fungal, Posterior hypopyon, Visual acuity reduced serious: 1 patientsex: 1 drugs: CLONAZEPAM, LEVETIRACETAM, VALPROIC ACID reactions: Drug ineffective serious: 1 patientsex: 1 drugs: HEPARIN SODIUM, RIVAROXABAN reactions: Haematuria, International normalised ratio increased serious: 1 patientsex: 1 drugs: BENDAMUSTINE, BRENTUXIMAB VEDOTIN reactions: Death, Off label use, Product use in unapproved indication serious: 1 patientsex: 2 drugs: OMEPRAZOLE reactions: Anaphylactic reaction, Drug hypersensitivity, Rash serious: 1 patientsex: 1 drugs: EVEROLIMUS, MYCOPHENOLIC ACID, PREDNISONE, TACROLIMUS reactions: Calciphylaxis serious: 1 patientsex: 2 drugs: CISPLATIN, SUNITINIB MALATE reactions: Neutropenia, Thrombocytopenia serious: 1 patientsex: 2 drugs: ACETAMINOPHEN, CRIZOTINIB reactions: Oesophagitis ulcerative serious: 1 patientsex: 1 drugs: DEPAMETHASONE, LAMOTRIGINE, PHENOBARBITAL, PHENYTOIN, VALPROIC ACID reactions: Gilberts syndrome, Hyperbilirubinaemia serious: 1 patientsex: 1 drugs: LANSOPRAZOLE, TESTOSTERONE, TAMSULOSIN reactions: Aortic stenosis, Hypercalcaemia, Hypervitaminosis A, Myocardial infarction, Renal impairment serious: 1 patientsex: 2 drugs: LISINOPRIL reactions: Inappropriate antidiuretic hormone secretion serious: 1 patientsex: 1 drugs: INFLIXIMAB reactions: Pulmonary tuberculosis serious: 1 patientsex: 2 drugs: USTEKINUMAB reactions: Psoriatic arthropathy serious: 1 patientsex: 1 drugs: THIOTINE reactions: Blindness, Optic nerve oedema, Pseudotumour cerebri serious: 1 patientsex: 2 drugs: AMIODARONE, DABIGATRAN ETEXILATE MESYLATE, RAMIPRIL reactions: Acute kidney injury, Glomerulonephritis anticoagulant, Haematuria, Hypotension, IgA nephropathy, Perirenal haematoma, Tubulointerstitial nephropathy serious: 1 patientsex: 2 drugs: ENTACAPONE, LEVODOPA, PRAMIPEXOLE, SELIGLINE, ZONISAMIDE reactions: Hallucination, auditory serious: 1 patientsex: 1 drugs: EVEROLIMUS, ENTECAVIR, LAMIVUDINE, TACROLIMUS reactions: Mucocutaneous tuberculosis serious: 1 patientsex: 2 drugs: QUETIAPINE FUMARATE reactions: Aphasia, Intentional product misuse, Intentional product misuse serious: 1 patientsex: 1 drugs: ERGOCALCIFEROL, GLIMEPIRIDE, LACTULOSE, METFORMIN HYDROCHLORIDE, PANTOPRAZOLE SODIUM, RIFaxiMIN, SEVELAMER reactions: Hypoglycaemia, Lactic acidosis, Overdose serious: 1 patientsex: 1 drugs: METFORMIN HYDROCHLORIDE, PASIREOTIDE, SITAGLIPTIN reactions: Abdominal pain, Diarrhoea, Fatigue, Hypoadrenalism, Hypotension, Off label use, Product use in unapproved indication serious: 1 patientsex: 1 drugs: AZITHROMYCIN ANHYDROUS, BETAMETHASONE, AMPICILLIN, GENTAMICIN, PENICILLIN G, MAGNESIUM SULFATE reactions: Drug ineffective, Exposure during pregnancy, Neonatal respiratory distress syndrome, Neonatal sepsis, Pneumonia serious: 1 patientsex: 1 drugs: BUPIVACAINE, ROPIVACAINE HYDROCHLORIDE reactions: Acute respiratory arrest, Bradycardia, Hypotension, Paralysis, Quadriplegia, Respiratory arrest, Toxicity to various agents serious: 1 patientsex: 2 drugs: BLEOMYCIN SULFATE, DACARBAZINE, DOXORUBICIN, VINBLASTINE reactions: Chronic heart failure, Cardiomyopathy serious: 1 patientsex: 2 drugs: FENTANYL, METHYLENE BLUE, DULOXETINE reactions: Drug interaction, Serotonin syndrome serious: 1 patientsex: 1 drugs: CARBOPLATIN, CETUXIMAB, CISPLATIN, DOCETAXEL, FLUOROURACIL, PACLITAXEL reactions: Bone marrow toxicity, Nausea serious: 1 patientsex: 1 drugs: ETANERCEPT reactions: Tuberculosis serious: 1 patientsex: 1 drugs: CEFUROXIME, GENTAMICIN reactions: Drug ineffective serious: 1 patientsex: 1 drugs: AMOXICILLIN, LITHIUM, LORAZEPAM, ZIPRASIDONE reactions: Anxiety, Bradykinesia, Drug ineffective, Drug intolerance, Nausea, Tremor serious: 1 patientsex: 2 drugs: CARBOPLATIN, DOCETAXEL, ERLOTINIB, GEMCITABINEGEMCITABINE HYDROCHLORIDE reactions: Disease progression, Ileus, Vomiting serious: 1 patientsex: 1 drugs: CHLORPROMAZINE, INSULIN NOS reactions: Neuroleptic malignant syndrome, Thyroid disorder serious: 1 patientsex: 1 drugs: AZATHIOPRINE, CYCLOSPORINE, OMEPRAZOLE, PREDNISONE reactions: Sporotrichosis serious: 1 patientsex: 2 drugs: PEMBROLIZUMAB reactions: Pneumonitis serious: 1 patientsex: 2 drugs: DEXAMETHASONE reactions: Adrenal insufficiency, Diabetes mellitus, Drug ineffective serious: 1 patientsex: 2 drugs: AZATHIOPRINE, HYDROXYCHLOROQUINE, MYCOPHENOLATE MOFETIL, PREDNISONE reactions: Aortic aneurysm, Abscess, Aortic rupture, Anaemia, Aortic dissection, Aortic aneurysm, Aortic leakage, Aortic aneurysm, Aortic aneurysm, Aortic aneurysm rupture, Aortic aneurysm, Aortic aneurysm dissection, Aortic aneurysm rupture, Aortic aneurysm ruptured, Aortic aneurysm ruptured, Aortic aneurysm, Aortic rupture, Aortic aneurysm ruptured, Aortic aneurysm, Aortic aneurysm ruptured, Aortic aneurysm, Aortic aneurysm ruptured, Aortic aneurysm, Aortic aneurysm ruptured, Aortic serious: 1 patientsex: 1 drugs: BLINATUMOMAB, CASPOFUNGIN, DEXAMETHASONE, MELPHALAN, VORICONAZOLE reactions: Hallucination, Neurotoxicity, Trichosporon infection serious: 1 patientsex: 1 drugs: ETOPOSIDE, PREDNISOLONE reactions: Dermatitis spongiform, Off label use, Product use in unapproved indication serious: 1 patientsex: 2 drugs: DAPSONE, PREDNISONE, SIROLIMUS, TACROLIMUS reactions: Drug interaction, Hypoxia serious: 1 patientsex: 2 drugs: WARFARIN reactions: Herpes zoster, Skin necrosis serious: 1 patientsex: 1 drugs: CISPLATIN, CYCLOPHOSPHAMIDE, DOXORUBICIN, ETOPOSIDE, IFOSFAMIDE, VINCRISTINE reactions: Acute kidney injury serious: 1 patientsex: 1 drugs: CLONAZEPAM, DEXAMETHASONE, VALPROIC ACID reactions: Drug ineffective, Hepatic function abnormal serious: 1 patientsex: 2 drugs: CYCLOSPORINE, METHOTREXATE, TACROLIMUS reactions: Acute myeloid leukaemia, Condition aggravated, Drug ineffective, Drug resistance, General physical health deterioration, Hallucination, auditory, Hypotension, Respiratory failure, Schizophrenia, Thrombocytopenia serious: 1 patientsex: 1 drugs: DOCETAXEL reactions: Recall phenomenon serious: 1 patientsex: 1 drugs: FLUOROURACIL, IRINOTECAN, LEUCOVORIN, OXALIPLATIN reactions: Organising pneumonia serious: 1 patientsex: 2 drugs: BOZITINIB, FLUVOXAMINE MALEATE, HYDROMORPHONE, NIVOLUMAB, OXYCODONE HYDROCHLORIDE reactions: Drug ineffective serious: 1 patientsex: 1 drugs: PREDNISONE, VANCOMYCIN reactions: Aortocavitary fistula, Bacteraemia, Cellulitis, Endocarditis, Multiple organ dysfunction syndrome, Staphylococcal infection serious: 1 patientsex: 2 drugs: INFLIXIMAB, METHOTREXATE reactions: Hyperglobulinaemia, Leishmaniasis, Pancytopenia serious: 1 patientsex: 1 drugs: AMIKACIN, AMPHOTERICIN B, CASPOFUNGIN, CLARITHROMYCIN, CIPROFLOXACIN, DOXYCYCLINE, LINEZOLID, MEROPENEM, METHYLPREDNISOLONE, RIFAMPIN, VORICONAZOLE reactions: Drug ineffective, Multiple organ dysfunction syndrome, Off label use serious: 1 patientsex: 2 drugs: DOCETAXEL, PALBOCICLIB reactions: Clostridium septicum infection, Multiple organ dysfunction syndrome, Septic shock serious: 1 patientsex: 2 drugs: ALCOHOL, OLANZAPINE reactions: Hyponatraemia, Overdose, Somnolence serious: 1 patientsex: 1 drugs: BICALUTAMIDE, GLIMEPIRIDE, METFORMIN HYDROCHLORIDE, RAMELTON, SITAGLIPTIN, SORAFENIB, ZOLPIDEM TARTRATE reactions: Anaemia, Diarrhoea haemorrhagic, Hepatocellular carcinoma, Intestinal infiltration, Tarry stools serious: 1 patientsex: 2 drugs: PREDNISONE, SOLUMERIDE reactions: Nocardiosis serious: 1 patientsex: 1 drugs: CIPROFLOXACIN reactions: Neutropenia, Pancytopenia, Rash serious: 1 patientsex: 2 drugs: OMEPRAZOLE, PREDNISONE, SIROLIMUS, TACROLIMUS reactions: Ascites, Gastrointestinal angioedema serious: 1 patientsex: 2 drugs: CIPROFLOXACIN, ECULIZUMAB, HYDRALAZINE HYDROCHLORIDE, MYCOPHENOLATE MOFETIL, PREDNISONE, TACROLIMUS reactions: Acute kidney injury, Atypical haemolytic uraemic syndrome, Haemolytic anaemia, Haemolytic anaemia, Haemolytic anaemia, Haemolytic anaemia, Oliguria, Renal failure, Thrombotic microangiopathy serious: 1 patientsex: 1 drugs: ALLOPURINOL, COLCHICINE, CLOPIDOGREL BISULFATE, DOXAZOSINDOXAZOSIN MESYLATE, FLUTICASONE, METOPROLOL, TORSEMIDE, VITAMIN D NOS, XARELTO reactions: Insulin autoimmune syndrome serious: 1 patientsex: 2 drugs: CYCLOPHOSPHAMIDE, DOXORUBICIN, PREDNISOLONE, RITUXIMAB, VINCRISTINE reactions: Inappropriate antidiuretic hormone secretion serious: 1 patientsex: 1 drugs: MYCOPHENOLATE MOFETIL, PREDNISOLONE, TACROLIMUS reactions: Mucormycosis serious: 1 patientsex: 1 drugs: AMIKACIN, CYTARABINE, LEVOFLOXACIN, MEROPENEM, MICAFUNGIN SODIUM, VANCOMYCIN reactions: Drug ineffective, Pneumonia stomatotrophomonas serious: 1 patientsex: 1 drugs: BLEOMYCIN SULFATE, CISPLATIN, DOXORUBICIN, ETOPOSIDE, IFOSFAMIDE, VINBLASTINE reactions: Nephropathy toxic serious: 1 patientsex: 2 drugs: MYCOPHENOLIC ACID, PREDNISONE reactions: Post transplant lymphoproliferative disorder serious: 1 patientsex: 2 drugs: BACLOFEN, ETORICOXIB, FENTANYL, PROPOFOL, ROCURONIUM BROMIDE, SEVOFLURANE, TRIAZOLAM reactions: Delirium serious: 1 patientsex: 2 drugs: RANIBIZUMAB reactions: Vitreous haemorrhage serious: 1 patientsex: 2 drugs: CEPHALEXIN, ERTAPENEM SODIUM reactions: Off label use serious: 1 patientsex: 1 drugs: CISPLATIN, CYTARABINE, DEXAMETHASONE, RITUXIMAB reactions: Drug ineffective serious: 2 patientsex: 2 drugs: LETROZOLE reactions: Abortion spontaneous, Maternal exposure before pregnancy serious: 1 patientsex: 2 drugs: MESALAMINE reactions: Eosinophilic pneumonia, Organising pneumonia serious: 1 patientsex: 2 drugs: TAMOXIFEN reactions: Endometrial stromal cell, Leiomyoma serious: 1 patientsex: 1 drugs: INDAPAMIDE, METFORMIN HYDROCHLORIDE, PERINDOPRIL, SITAGLIPTIN reactions: Megaloblastic anaemia serious: 1 patientsex: 1 drugs: BEVACIZUMAB, FLUOROURACIL, LEUCOVORIN, OXALIPLATIN reactions: Drug ineffective serious: 2 patientsex: 2 drugs: ACITRETIN, CLOBETASOL PROPIONATE, METHOTREXATE, MINOCYCLINE HYDROCHLORIDE, PREDNISONE reactions: Drug ineffective serious: 1 patientsex: 2 drugs: LEUPROLIDE ACETATE, MEDROXYPROGESTERONE reactions: Vaginal haemorrhage serious: 1 patientsex: 1 drugs: LAMOTRIGINE, METFORMIN HYDROCHLORIDE, METOPROLOL, PREGABALIN, QUETIAPINE, VENLAFAXINE HYDROCHLORIDE reactions: Coma, Hypotension, Intentional overdose, Respiratory failure, Suicide attempt, Tachycardia serious: 1 patientsex: 1 drugs: ALTEPLASE reactions: Angioedema serious: 1 patientsex: 1 drugs: DEXAMETHASONE, METHYLPREDNISOLONE reactions: Acute respiratory failure, Respiratory tract infection serious: 1 patientsex: 2 drugs: ALPRAZOLAM, ACYCLOVIR, CEFTRIAXONE, DEXAMETHASONE, FENTANYL, MIDAZOLAM HYDROCHLORIDE, LORAZEPAM, MIDAZOLAM HYDROCHLORIDE, VANCOMYCIN reactions: Drug dependence, Drug withdrawal syndrome, Drug dependence serious: 1 patientsex: 1 drugs: IPILIMUMAB, NIVOLUMAB, PREDNISONE reactions: Colitis, Drug intolerance, Haematochezia, Pneumoperitoneum serious: 1 patientsex: 1 drugs: ACETAMINOPHEN, ACETAMINOPHENHYDROCORTISONE, ISONIAZID, LEVOFLOXACIN, MEROPENEM, POTASSIUM, PYRAZINAMIDE, RIFAMPIN, STREPTOMYCINSTREPTOMYCIN SULFATE reactions: Hypoglycaemia, Hyponatraemia, Off label use, Pyrexia, Respiratory failure serious: 1 patientsex: 2 drugs: CYCLOPHOSPHAMIDE, DOXORUBICIN, IFOSFAMIDE, VINCRISTINE reactions: Fungal infection, Neutropenia, Thrombocytopenia serious: 1 patientsex: 1 drugs: CYTARABINE, IDARUBICIN reactions: Acute respiratory distress syndrome, Immune reconstitution inflammatory syndrome, Septic shock serious: 1 patientsex: 1 drugs: METHYLPREDNISOLONE, RITUXIMAB reactions: Drug ineffective serious: 1 patientsex: 2 drugs: PREDNISOLONE reactions: Condition aggravated, Infection, Streptococcal infection serious: 1 patientsex: 2 drugs: BEVACIZUMAB, DEXAMETHASONE, RANIBIZUMAB reactions: Drug ineffective serious: 1 patientsex: 1 drugs: PREDNISOLONE reactions: Septic shock serious: 1 patientsex: 1 drugs: TRIAMCINOLONE ACETONIDE reactions: Endophthalmitis serious: 1 patientsex: 1 drugs: CYCLOPHOSPHAMIDE, DOXORUBICIN, ETOPOSIDE, FLUDARABINE PHOSPHATE, IMATINIB, PREDNISONE, RITUXIMAB, VINCRISTINE reactions: Diffuse large B-cell lymphoma, Richters transformation serious: 1 patientsex: 1 drugs: ASPIRIN, BUDESONIDE, CYCLOPHOSPHAMIDE, HYDROCORTISONE, METHYLPREDNISOLONE, PREDNISOLONE, RITUXIMAB, VINCRISTINE reactions: Drug ineffective, Off label use serious: 1 patientsex: 2 drugs: BLINATUMOMAB, CYCLOPHOSPHAMIDE, DEXAMETHASONE, INOTUZUMAB, MERCAPTOPURINE, METHOTREXATE, PREDNISONE, RITUXIMAB, VINCRISTINE reactions: Abdominal pain, Nausea, Recurrent lymphoma serious: 1 patientsex: 2 drugs: AMRUBICIN, CARBOPLATIN, CISPLATIN, ETOPOSIDE reactions: Drug ineffective serious: 1 patientsex: 2 drugs: CISPLATIN, ENOXAPARIN, ETOPOSIDE, HYDROCORTISONE, IRON, METOCLOPRAMIDE, ONDANSETRON reactions: Anaemia, Dysphagia, Odynophagia, Oral mucosal inflammation, Oral dermatitis, Foetal exposure during pregnancy, Odynophagia, Oral mucosal inflammation, Oral dermatitis, Oral mucosal inflammation, Oral dermatitis, Premature baby, Premature delivery, Vomiting serious: 1 patientsex: 1 drugs: CISPLATIN, ETOPOSIDE, IRINOTECAN reactions: Hepatic encephalopathy, Jaundice serious: 1 patientsex: 2 drugs: MELPHALAN reactions: Metastases to pelvis serious: 1 patientsex: 2 drugs: LEVETIRACETAM, VALPROIC ACID reactions: Myoclonus, Off label use, Seizure serious: 1 patientsex: 2 drugs: CYCLOPHOSPHAMIDE, DOCETAXEL, DOXORUBICIN HYDROCHLORIDE, EPIRUBICIN, FLUTICASONE PROPIONATE reactions: Cardiac failure, Cardiomyopathy serious: 1 patientsex: 2 drugs: METHYLDOPA reactions: Exposure during pregnancy serious: 1 patientsex: 2 drugs: CETIRIZINE HYDROCHLORIDE, EPINEPHRINE, FAMOTIDINE, FexOFENADINE, DIPHENHYDRAMINE, LORATADINE, OMALIZUMAB reactions: Anaphylactic reaction, Cardiac arrest serious: 1 patientsex: 1 drugs: AMPICILLIN SODIUMSULBACTAM SODIUM, CYCLOSPORINE, METHYLPREDNISOLONE, MEROPENEM, METHYLPREDNISOLONE SODIUM SUCCINATE, PREDNISOLONE reactions: Bronchiectasis, Bronchopulmonary aspergillosis, Drug ineffective, Interstitial lung disease, Pulmonary necrosis, Respiratory failure, Respiratory failure, Sputum exfiltration serious: 1 patientsex: 2 drugs: SORAFENIB, VINORELBINE TARTRATE reactions: Febrile neutropenia serious: 1 patientsex: 1 drugs: DENOSUMAB, IPILIMUMAB, NIVOLUMAB, PREDNISOLONE, TRAMETHINIB reactions: Iridocyclitis, Rash serious: 1 patientsex: 1 drugs: MELPHALAN reactions: Myelodysplastic syndrome serious: 1 patientsex: 2 drugs: AMLODIPINE BESYLATE, LOSARTAN reactions: Drug-induced liver injury serious: 1 patientsex: 1 drugs: BASILIXIMAB, MYCOPHENOLATE MOFETIL, PREDNISOLONE, TACROLIMUS reactions: Meningitis cryptococcal, Fungaemia serious: 1 patientsex: 1 drugs: METFORMIN HYDROCHLORIDE reactions: Lichen planus serious: 1 patientsex: 1 drugs: HYDROCHLOROTHIAZIDETELMISARTAN reactions: Urticarial vasculitis serious: 1 patientsex: 1 drugs: BORTEZOMIB, CISPLATIN, CYCLOPHOSPHAMIDE, DEXAMETHASONE, EPIRUBICIN, ETOPOSIDE, LENALIDOMIDE reactions: Neutropenia, Thrombocytopenia serious: 1 patientsex: 1 drugs: LANREOTIDE, TEMOZOLOMIDE reactions: Bone pain, Bone marrow failure, Fatigue, Nausea, Neutropenia, Thrombocytopenia serious: 1 patientsex: 1 drugs: AMOXICILLIN reactions: Drug ineffective serious: 1 patientsex: 2 drugs: CARBOPLATIN, PACLITAXEL reactions: Neuropathy peripheral, Neutropenia serious: 1 patientsex: 2 drugs: CYCLOPHOSPHAMIDE, CYCLOSPORINE, FLUOROURACIL, METHOTREXATE reactions: Acute myeloid leukaemia, Cytopenia, Dermatitis exsudative, Dermatitis bullous, Dermatitis bullous, Dermatitis bullous, Dermatitis bullous, Dermatitis bullous, Dermatitis bullous, Dermatitis bullous, Dermatitis bullous, Dermatitis bullous, Dermatitis bullous, Dermatitis bullous, Dermatitis bullous, Dermatitis bullous, Dermatitis bullous, Dermatitis bullous, Dermatitis bullous, Dermatitis bullous, Dermatitis bullous, Dermatitis bullous, Dermatitis bullous, Dermatitis bullous, Dermatitis bullous, Dermatitis bullous, Dermatitis bullous, Dermatitis bullous, Dermatitis bullous, Dermatitis bullous, Dermatitis bullous, Dermatitis bullous, Dermatitis bullous, Dermatitis bullous, Dermatitis bullous serious: 1 patientsex: 2 drugs: PEGINTERFERON ALFA-2B, RIBAVIRIN reactions: Hepatitis C, Treatment failure serious: 1 patientsex: 1 drugs: ATORVASTATIN, BISOPROLOL, IBUPROFEN, WARFARIN reactions: Confusional state, Inappropriate antidiuretic hormone secretion serious: 1 patientsex: 2 drugs: CARBOPLATIN, EPIRUBICIN, ETOPOSIDE, GESTODONE, IFOSFAMIDE reactions: Inferior vena cava syndrome serious: 1 patientsex: 1 drugs: GANCICLOVIR, VALGANCICLOVIR reactions: Toxic encephalopathy serious: 1 patientsex: 2 drugs: CYCLOPHOSPHAMIDE, DOCETAXEL reactions: Diarrhoea, Diarrhoea cholestatic, Diarrhoea haemorrhagic, Diarrhoea haemorrhagic, Diarrhoea haemorrhagic, Diarrhoea haemorrhagic, Diarrhoea haemorrhagic, Diarrhoea haemorrhagic, Diarrhoea haemorrhagic, Diarrhoea haemorrhagic, Diarrhoea haemorrhagic, Diarrhoea haemorrhagic, Diarrhoea haemorrhagic, Diarrhoea haemorrhagic, Diarrhoea haemorrhagic, Diarrhoea haemorrhagic, serious: 1 patientsex: 2 drugs: AZATHIOPRINE, INFLIXIMAB, METHADNONE, PREDNISONE reactions: Abdominal pain, Abdominal pain upper, Abdominal pain lower, Abdominal pain upper, Abdominal wall bruising, Abdominal pain upper, Abdominal wall stenosis, Abdominal pain upper, Abdominal wall oedema, Abdominal pain upper, Abdominal wall bruising, Abdominal pain upper, Abdominal wall oedema, Abdominal wall bruising, Abdominal pain upper, Abdominal wall oedema, Abdominal wall bruising, Abdominal wall oedema, Abdominal wall oedema, Abdominal wall stenosis, Abdominal wall oedema, Abdominal wall bruising, Abdominal wall oedema, Abdominal wall oedema, Abdominal wall stenosis, Abdominal wall oedema, Abdominal wall oe serious: 1 patientsex: 2 drugs: BEVACIZUMAB reactions: Posterior vitreous haemorrhage serious: 1 patientsex: 1 drugs: GEMCITABINEGEMCITABINE HYDROCHLORIDE, VALPROIC ACID reactions: Febrile neutropenia, Lymphocytopenia, Myelosuppression serious: 1 patientsex: 1 drugs: CARBOPLATIN, PACLITAXEL reactions: Anaemia, Neuropathy peripheral serious: 1 patientsex: 2 drugs: CYCLOPHOSPHAMIDE, DOXORUBICIN HYDROCHLORIDE reactions: Dermatomyositis serious: 1 patientsex: 2 drugs: ATORVASTATIN, BISOPROLOL, CYAMEMAZINE, LERCANIDIPINE, METFORMIN HYDROCHLORIDE, ZUCLPENTHIXOL ACETATE reactions: Accidental overdose, Drug administration error, Hypotension, Neuroleptic malignant syndrome, Suicide attempt serious: 1 patientsex: 2 drugs: ERLOTINIB reactions: Delusional ideation, Delusion, Hallucination, Lacunar infarction, Memory impairment, Sluggishness serious: 1 patientsex: 1 drugs: ASPARAGINASE, CYCLOPHOSPHAMIDE, METHOTREXATE, MYCOPHENOLATE MOFETIL, PREDNISOLONE, TACROLIMUS reactions: Epstein-Barr virus infection, Post transplant lymphoproliferative disorder serious: 1 patientsex: 2 drugs: ATORVASTATIN, LEVOTHYROXINE, METOPROLOL, VALPROIC ACID reactions: Ammonia increased, Aggression, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Ag serious: 1 patientsex: 1 drugs: IVERMECTIN reactions: Blindness, Bradycardia, Generalised tonic-clonic seizure, Mydriasis, Optic nerve haemorrhage, Seizure, Vision blurred serious: 1 patientsex: 2 drugs: ESTRADIOL, PROGESTERONE reactions: Adrenal adenoma, Cushings syndrome, Drug ineffective, Virilisation serious: 1 patientsex: 2 drugs: AMPHOTERICIN B, AMPHOTERICIN C, FLUCONAZOLE, FLUCONAZOLE SODIUM, GENTAMICIN, RITUXIMAB, TACROLIMUS, VANCOMYCIN reactions: Bacteraemia, Drug ineffective, Lethargy, Pyrexia, Staphylococcal infection serious: 1 patientsex: 2 drugs: ASPIRIN reactions: Retinopathy serious: 1 patientsex: 2 drugs: ASPIRIN, CEFEPIME HYDROCHLORIDE, DAPTOMYCIN, INSULIN NOS, METOPROLOL SUCCINATE, PANTOPRAZOLE SODIUM, PRASUGREL, LISINOPRIL, METOPROLOL SUCCINATE, PRASUGREL HYDROCHLORIDE, PRASUGREL BISULFATE reactions: Acute kidney injury, Confusional state, Drug ineffective, Drug interaction, Toxic encephalopathy serious: 1 patientsex: 1 drugs: ACETAMINOPHEN, FENTANYL, LIDOCAINE, LIDOCAINE HYDROCHLORIDE, PRILOCAINE, TRAMADOL reactions: Constipation, Delirium, Drug ineffective, Somnolence serious: 1 patientsex: 2 drugs: AZITHROMYCIN ANHYDROUS, CEFTRIAXONE, METHYLPREDNISOLONE, REMDESIVIR reactions: Electrocardiogram QT prolonged, Sinus bradycardia serious: 1 patientsex: 2 drugs: CARBOPLATIN, VINBLASTINE reactions: Arthralgia, Pharyngitis viral, Synovitis serious: 1 patientsex: 2 drugs: CILASTATIN SODIUMIMIPENEM, FENTANYL CITRATE, HYDROMORPHONE HYDROCHLORIDE, LISINOPRIL, MIDAZOLAM HYDROCHLORIDE, MICAFUNGIN SODIUM, ONDANSETRON, OLANZAPINE, PIPERACILLIN SODIUMTAZOBACTAM SODIUM, PIPERACILLIN SODIUMTAZOBACTAM SODIUM, PIPERACILLIN SODIUMTAZOBACTAM SODIUM, PIPERACILLIN SODIUMTAZOBACTAM SODIUM, PIPERACILLIN SODIUMTAZOBACTAM SODIUM, PIPERACILLIN SODIUMTAZOBACTAM SODIUM, PIPERACILLIN SODIUMTAZOBACTAM SODIUM, PIPERACILLIN SODIUMTAZOBACTAM S serious: 1 patientsex: 2 drugs: ALENDRONATE SODIUM reactions: Osteonecrosis of jaw serious: 1 patientsex: 2 drugs: CEFTRIAXONE, FUROSEMIDE, VANCOMYCIN reactions: Drug ineffective serious: 1 patientsex: 1 drugs: BUSULFAN, CYCLOPHOSPHAMIDE, CYCLOSPORINE, METHOTREXATE, METHYLPREDNISOLONE, THYMOCYTE IMMUNE GLOBULIN NOS reactions: Acute graft versus host disease in gastrointestinal tract, Acute graft versus host disease in liver, Graft versus host disease in hepatic axis, Neutropenic colitis, Oral mucosal inflammation, Pneumonia, Thrombocytopenia serious: 1 patientsex: 1 drugs: PHENYTOIN reactions: Fall, Pneumonia aspiration, Toxicity to various agents serious: 1 patientsex: 2 drugs: DOXYCYCLINE reactions: Drug hypersensitivity, Drug hypersensitivity, Nausea serious: 1 patientsex: 2 drugs: CYCLOSPORINE, FLUDARABINE PHOSPHATE, MYCOPHENOLATE MOFETIL, THIOTEPA, TREOSULFAN reactions: Arterial hypertension, Neurotoxicity serious: 1 patientsex: 1 drugs: DENOSUMAB, IPILIMUMAB, NIVOLUMAB reactions: Autoimmune thyroiditis, Colitis, Diarrhoea, Diabetes mellitus, Hepatitis, Hyperglycaemia, Ketoacidosis, Immune-mediated diabetes mellitus, Immune-mediated thyroiditis, Immune-mediated hepatitis, Immune-mediated thyroiditis, Immune-mediated hepatitis, Immune-mediated thyroiditis, Immune-mediated hepatitis, Immune-mediated thyroiditis, Immune-mediated hepatitis, Immune-mediated hepatitis, Immune-mediated thyroiditis, Immune-mediated hepatitis, Immune-mediated thyroiditis, Immune-mediated hepatitis, Immune-mediated thyroiditis, Immune-mediated hepatitis, Immune-mediated thyroiditis, Immune-mediated hepatitis, Immune-mediated thyroiditis, Immune-mediated hepatitis, Immune serious: 1 patientsex: 2 drugs: CAPECITABINE, CYCLOPHOSPHAMIDE, DOCETAXEL, DOXORUBICIN, ERIBULIN, FLUOROURACIL, LEUPROLIDE ACETATE, TAMOXIFEN, ZOLEDRONIC ACID reactions: Drug ineffective, Pulmonary artery thrombosis, Respiratory failure serious: 1 patientsex: 2 drugs: BEVACIZUMAB, FLUOROURACIL, LEUCOVORIN, OXALIPLATIN reactions: Immune thrombocytopenic purpura serious: 1 patientsex: 1 drugs: ASPIRIN, CLOPIDOGREL BISULFATE reactions: Drug resistance, Stent thrombosis serious: 1 patientsex: 1 drugs: ENOXAPARIN, HYDROXYCHLOROQUINE, LOSARTAN, LOPINAVIRRITONAVIR, OXYGEN, RIVAROXABAN reactions: Pulmonary embolism serious: 1 patientsex: 2 drugs: CAPECITABINE, LAPATINIB reactions: Dermatomyositis serious: 1 patientsex: 2 drugs: CYCLOSPORINE, DEXAMETHASONE, METHYLPREDNISOLONE, MOMETASONE FUROATE, PREDNISOLONE, SODIUM CHLORIDE, TRIAMCINOLONE reactions: Drug interaction, Hypersensitivity, Urticaria serious: 1 patientsex: 1 drugs: ALEMTUZUMAB, CYCLOSPORINE, DEXAMETHASONE, ETOPOSIDE, HUMAN IMMUNOGLOBULIN G, NITROMANTINE, RITUXIMAB, VANCOMYCIN reactions: Acute kidney injury, Hyperkalaemia, Lactic acidosis, Multiple organ dysfunction syndrome, Septic shock serious: 1 patientsex: 2 drugs: CARBAMAZEPINE, CLOBAZAM, LEVETIRACETAM, PERAMPANEL reactions: Drug ineffective serious: 1 patientsex: 1 drugs: CISPLATIN, GEMCITABINEGEMCITABINE HYDROCHLORIDE reactions: Thrombotic microangiopathy serious: 1 patientsex: 1 drugs: ACETAMINOPHEN, AMIKACIN, MORPHINE SULFATE, PROTHROMBIN reactions: Acute kidney injury, Renal pseudoaneurysm ruptured, Renal parenchymal haematoma serious: 1 patientsex: 2 drugs: CYTARABINE, DEXAMETHASONE, METHOTREXATE, PREDNISOLONE reactions: Decreased appetite, Decreased appetite, Decreased appetite, Gait disturbance, Myelopathy, Myopathy, Paraparesis, Vitamin B12 decreased, Vitamin C decreased, Vitamin D decreased serious: 1 patientsex: 2 drugs: CAPECITABINE, CARBOPLATIN, DOCETAXEL, LAPATINIB, PERTUZUMAB, TRASTUZUMAB reactions: Disease progression serious: 1 patientsex: 1 drugs: SORAFENIB reactions: Diarrhoea, Fatigue, Nausea, Palmar-plantar erythrodysaesthesia syndrome, Retinal tear, Toxicity to various agents serious: 1 patientsex: 2 drugs: BEVACIZUMAB, CARBOPLATIN, GEMCITABINEGEMCITABINE HYDROCHLORIDE, IFOSFAMIDE, NIVOLUMAB, PACLITAXEL reactions: Disease progression serious: 1 patientsex: 2 drugs: MEDROXYPROGESTERONE ACETATE reactions: Arthritis, Disease recurrence, Lymph node enlargement, Product use in unapproved indication serious: 1 patientsex: 2 drugs: BOSENTAN, FUROSEMIDE, SILDENAFIL reactions: Ascites, Central venous thrombosis, Intestinal obstruction, Pleural effusion, Respiratory tract infection, Scoliosis, Stomatitis, Treatment failure serious: 1 patientsex: 1 drugs: ARSENTIX, CYTARABINE, IDARUBICIN, TRETINOIN reactions: Acute myeloid leukaemia recurrent, Myelitis serious: 1 patientsex: 2 drugs: CYCLOPHOSPHAMIDE, DOBUTAMINEDOBUTAMINE HYDROCHLORIDE, HUMAN IMMUNOGLOBULIN G, METHYLPREDNISOLONE, MYCOPHENOLIC ACID, PREDNISONE, SOLUMERIDE reactions: Drug ineffective, Drug resistance, Off label use serious: 1 patientsex: 1 drugs: AMLODIPINE BESYLATE, GLIMEPIRIDE, METFORMIN HYDROCHLORIDE, SPIRONOLACTONE, TELMISARTAN, VORICONAZOLE reactions: Hypercalcaemia, Hyperkalaemia, Proteinuria, Quadriparesis serious: 1 patientsex: 1 drugs: FENTANYL, HYDROMORPHONE, PROPOFOL, ROCURONIUM BROMIDE reactions: Respiratory depression serious: 1 patientsex: 2 drugs: DICLOFENAC SODIUM reactions: Embolia cutis medicamentosa serious: 1 patientsex: 2 drugs: ASPIRIN, BISOPROLOL, CALCIUM CARBONATE, CHOLECALCIFEROL, CHOLECALCIFEROL SODIUM, CHOLECALCIFEROL HYDROCHLORIDE, CYCLOSPORINE, HYDROCORTISONE, HYDROXYCHLOROQUINE, HYDROXYCHLOROQUINE SULFATE, HYDROXYCHLOROQUINE SULFATE, HYDROXYCHLOROQUINE SULFATE, HYDROXYCHLOROQUINE SULFATE, HYDROXYCHLOROQUINE SULFATE, HYDROXYCHLOROQUINE, HYDROXYCHLOROQUINE, HYDROXYCHLOROQUINE SULFATE, HYDROXYCHLOROQUINE SULFATE, HYDROXYCHLOROQUINE SULFATE, HYDROXYCHLORO serious: 1 patientsex: 2 drugs: ARIPIPRAZOLE, FLUPHENAZINE ENTHASETATE, HALOPERIDOL, SERTRALINE HYDROCHLORIDE reactions: Multiple system atrophy serious: 1 patientsex: 2 drugs: AMANTADINE HYDROCHLORIDE, CARBIDOPALEVODOPA, ENTACAPONE, PRAMIPEXOLE, ROPINEROLE, TOLCAPONE reactions: Drug intolerance, Parkinsons disease serious: 1 patientsex: 2 drugs: TREPROSTINIL reactions: Gastrointestinal disorder serious: 1 patientsex: 2 drugs: AXITINIB, PEMBROLIZUMAB reactions: Haematuria serious: 1 patientsex: 1 drugs: LENVATINIB reactions: Pneumothorax serious: 1 patientsex: 2 drugs: AMLODIPINE BESYLATE, ASPIRIN, BENDROFLUMETHIAZIDE, CETIRIZINE HYDROCHLORIDE, DICLOFENAC, HYDROCORTISONE, IBUPROFEN, METFORMIN HYDROCHLORIDE, PAROXETINE, RAMIPRIL, SIMVASTATIN, TOPIRAMATE reactions: Adrenal insufficiency, Drug interaction, Drug level decreased, Drug level increased, Drug interaction, Drug level decreased, Fatigue, Hypertension, Osteopenia, Osteopenia, Osteopenia fracture, Osteopenia, Osteopenia, Osteopenia, Osteopenia fracture, Osteopenia, Osteopenia fracture, Osteopenia, Osteopenia fracture, Osteopenia fracture, Osteopenia fracture, Osteopenia fracture, Osteopenia fracture, Osteopenia fracture, Osteopenia fracture, Osteopenia serious: 1 patientsex: 2 drugs: ASPIRIN reactions: Gallbladder rupture serious: 1 patientsex: 1 drugs: MEROPENEM reactions: Drug ineffective serious: 1 patientsex: 2 drugs: DIGOXIN, FUROSEMIDE, INSULIN NOS, METHIMAZOLE, RAMIPRIL, PROPRANOLOL HYDROCHLORIDE reactions: Agranulocytosis serious: 1 patientsex: 1 drugs: CYCLOPHOSPHAMIDE, DOXORUBICIN, PREDNISONE, RITUXIMAB, VINCRISTINE reactions: Crohns disease serious: 1 patientsex: 2 drugs: CAPECITABINE, LOVASTATIN reactions: Dysaesthesia, Nail toxicity, Onychomadesis serious: 1 patientsex: 1 drugs: PREDNISONE reactions: Drug ineffective serious: 1 patientsex: 2 drugs: ALENDRONIC ACID reactions: Ulna fracture serious: 1 patientsex: 1 drugs: CYCLOPHOSPHAMIDE, CYTARABINE, ETOPOSIDE, FLUDARABINE PHOSPHATE, LINEZOLID, METHOTREXATE, TACROLIMUS, VANCOMYCIN reactions: Cytomegalovirus meningitis, Enterococcal infection, Haemophagocytic syndrome, Meningitis viral, Meningitis viral reactivation, Sepsis serious: 1 patientsex: 2 drugs: EFAVIRENZ, LAMIVUDINE, TENOFOVIR DISOPROXIL FUMARATE reactions: Aplasia cutis congenita serious: 1 patientsex: 2 drugs: AZITHROMYCIN ANHYDROUS, CEFTRIAXONE, MEROPENEM reactions: Burkholderia pseudomallei infection, Drug ineffective serious: 1 patientsex: 1 drugs: PEMBROLIZUMAB, VALPROIC ACID reactions: Drug resistance serious: 1 patientsex: 2 drugs: DACTINOMYCIN, ETOPOSIDE, IFOSFAMIDE, VINCRISTINE reactions: Acute hepatic failure, Acute kidney injury, Disseminated intravascular coagulation, Rhabdomyolysis serious: 1 patientsex: 2 drugs: AMOXICILLIN, LEVOFLOXACIN, ANASTROVOL reactions: Drug ineffective, Pulmonary cryptococcosis serious: 1 patientsex: 2 drugs: DOXYCYCLINE reactions: Antineutrophil cytoplasmic antibody positive vasculitis serious: 1 patientsex: 2 drugs: CISPLATIN, DOCETAXEL, ERIBULIN reactions: Malignant neoplasm progression serious: 1 patientsex: 2 drugs: AMLODIPINE BESYLATE reactions: Condition aggravated, Drug ineffective, Tachycardia serious: 1 patientsex: 1 drugs: GENTAMICIN reactions: Renal failure serious: 1 patientsex: 1 drugs: METFORMIN HYDROCHLORIDE reactions: Toxic encephalopathy serious: 1 patientsex: 1 drugs: MACITENTAN, RIOCIGUAT reactions: Drug interaction, Pulmonary arterial hypertension serious: 1 patientsex: 1 drugs: MYCOPHENOLATE MOFETIL reactions: Posterior reversible encephalopathy syndrome serious: 1 patientsex: 2 drugs: FINGOLIMOD reactions: Disease rebound serious: 1 patientsex: 2 drugs: DISOPYRAMIDE reactions: Cardiogenic shock, Depressed level of consciousness, Drug level increased, Overdose, Ventricular tachycardia serious: 1 patientsex: 2 drugs: CAPECITABINE reactions: Breast cancer metastatic serious: 1 patientsex: 1 drugs: NIVOLUMAB reactions: Aphthous ulcer, Gastritis, Immune-mediated enterocolitis, Oesophagitis serious: 1 patientsex: 1 drugs: CAPECITABINE reactions: Dehydration, Dehydration, Electrolyte imbalance, Erythrodysaesthesia, Haematuria, Palmar-plantar erythrodysaesthesia syndrome, Peripheral dehydration, Skin exfoliation, Skin ulcer serious: 1 patientsex: 2 drugs: CLOBAZAM, TOPIRAMATE, VALPROIC ACID reactions: Status epilepticus serious: 1 patientsex: 1 drugs: BEVACIZUMAB, IRINOTECAN, LOMUSTINE, TEMOZOLOMIDE reactions: Glioblastoma serious: 1 patientsex: 1 drugs: CIPROFLOXACIN reactions: Peritonitis bacterial serious: 1 patientsex: 1 drugs: LEVOFLOXACIN reactions: Drug resistance serious: 1 patientsex: 2 drugs: CAPECITABINE, CISPLATIN, DOCETAXEL reactions: Clostridium difficile colitis, Febrile neutropenia serious: 1 patientsex: 2 drugs: CLOZAPINE, HALOPERIDOL, OLANZAPINE, RISPERIDONE reactions: Drug ineffective, Hepatotoxicity, Pleural effusion serious: 1 patientsex: 1 drugs: CAPECITABINE, CISPLATIN, DOCETAXEL, FLUOROURACIL reactions: Bone marrow failure serious: 1 patientsex: 2 drugs: ASPIRIN, CYTARABINE, DAUNORUBICIN reactions: Febrile neutropenia, Myocarditis serious: 1 patientsex: 1 drugs: CLOZAPINE, TOPIRAMATE reactions: Agranulocytosis, Drug interaction, Neutropenia serious: 1 patientsex: 1 drugs: HYDRALAZINE HYDROCHLORIDE, ISOSORBIDE DINITRATE reactions: Hypotension serious: 1 patientsex: 1 drugs: CHLODRIDAZEPOXIDE, LACTULOSE reactions: Hepatic encephalopathy, Toxicity to various agents serious: 1 patientsex: 1 drugs: CYCLOPHOSPHAMIDE, PREDNISOLONE, RITUXIMAB, VINCRISTINE reactions: Cholecystitis acute, Enterovirus infection, Hepatitis fulminant, Multiple organ dysfunction syndrome, Sepsis serious: 1 patientsex: 2 drugs: CLARITHROMYCIN, ENOXAPARIN, WARFARIN reactions: Drug interaction, International normalising ratio decreased, Pulmonary embolism serious: 1 patientsex: 2 drugs: ASPIRIN, CLOPIDOGREL BISULFATE, PREDNISOLONE reactions: Foetal exposure during pregnancy, Low birth weight baby, Premature baby serious: 1 patientsex: 2 drugs: CAPECITABINE, DENOSUMAB, DOCETAXEL, GEMCITABINEGEMCITABINE HYDROCHLORIDE, LAPTANIB, PERTUZUMAB, ZOLEDRONIC ACID reactions: Disease progression serious: 1 patientsex: 2 drugs: TAZOCIN reactions: Off label use serious: 1 patientsex: 1 drugs: CARBOPLATIN, PACLITAXEL reactions: Palmar-plantar erythrodysaesthesia syndrome serious: 1 patientsex: 1 drugs: CASPOFUNGIN, CILASTATIN SODIUMIMIPENEM, METHYLPREDNISOLONE, MYCOPHENOLATE MOFETIL, PREDNISONE, SULFAMETHOXAZOLETRIMETHOPRIM, TEICOPLANIN, TACROLIMUS reactions: Candida infection, Fungal infection, Multiple organ dysfunction syndrome, Pneumonia, Sepsis, Trichosporon infection serious: 1 patientsex: 2 drugs: CIPROFLOXACIN, CEFTRIAXONE, SULFAMETHOXAZOLETRIMETHOPRIM reactions: Acute kidney injury, Endocarditis, Lactic acidosis, Pulmonary hypertension, Septic shock, Thrombocytopenia serious: 1 patientsex: 1 drugs: METHOTREXATE reactions: Alopecia universalis, Alopecia areata serious: 1 patientsex: 1 drugs: APIXABAN, ASPIRIN, CYCLOPHOSPHAMIDE, CYCLOSPORINE, DOBUTAMINEDOBUTAMINE HYDROCHLORIDE, FUROSEMIDE, LEVOFLOXACIN, PRASUGREL, PREDNISOLONE, REPAGLINIDE, TENELIGLIPTIN reactions: Acute kidney injury, Nocardiosis, Prostatic abscess serious: 1 patientsex: 2 drugs: METHOTREXATE reactions: Erythema multiforme, Pancytopenia, Stomatitis serious: 1 patientsex: 1 drugs: ASPIRIN, ATORVASTATIN, HYDROCHLOROTHIAZIDE, LOSARTAN reactions: Lupus-like syndrome serious: 1 patientsex: 1 drugs: LEFLUNOMIDE, METHOTREXATE reactions: Mycoplasmal pneumonia, Legionella infection serious: 1 patientsex: 2 drugs: MYCOPHENOLATE MOFETIL, PREDNISONE reactions: Adrenal insufficiency, Coagulopathy, Hepatic steatosis, Hepatic failure, International normalised ratio increased serious: 1 patientsex: 2 drugs: CYCLOSPORINE, MYCOPHENOLATE MOFETIL, PREDNISONE, TACROLIMUS reactions: Diffuse large B-cell lymphoma, Epstein-Barr virus infection, Intestinal perforation, Lymphadenectasis, Pleural effusion, Pleural effusion, Pyrexia, Splenomegaly, Stomatitis serious: 1 patientsex: 2 drugs: BEVACIZUMAB, CISPLATIN, PACLITAXEL, URSODIOL reactions: Bacteraemia, Cholangitis sclerosing serious: 1 patientsex: 2 drugs: CARBOPLATIN, CISPLATIN, DOXORUBICIN, ETOPOSIDE, IFOSFAMIDE, MESNA, VINCRISTINE reactions: Bone marrow failure, Neutropenia serious: 1 patientsex: 1 drugs: NATALIZUMAB reactions: Progressive multifocal leukoencephalopathy serious: 1 patientsex: 2 drugs: CYCLOBENZAPRINE, FLUOXETINE HYDROCHLORIDE, HYDROCODONE reactions: Adrenal insufficiency, Adrenal suppression, Colitis microscopic, Drug ineffective, Fatigue, Hyperhidrosis, Muscle spasms, Muscle twitching, Muscle spasms, Muscle twitching, Muscle spasms, Muscle twitching, Muscle spasms, Muscle spasms, Muscle spasms, Muscle spasms, Muscle spasms, Muscle spasms, Muscle spasms, Muscle spasms, Muscle spasms, Muscle spasms, Muscle spasms, Muscle spasms, Muscle spasms, Muscle spasms, Muscle spasms, Muscle spasms, Muscle spasms, Muscle spasms, Muscle spasms, Muscle spasms, Mus serious: 1 patientsex: 2 drugs: ASPIRIN, HUMAN IMMUNOGLOBULIN G, METILPRREDNISOLONE, PREDNISONE reactions: Drug ineffective, Treatment failure serious: 1 patientsex: 1 drugs: CLONAZEPAM reactions: Drug-induced liver injury, Hyperglycaemic crisis, Hepatic function abnormal serious: 1 patientsex: 1 drugs: CISPLATIN, VINORELBINEVINORELBINE TARTRATE reactions: Colitis ulcerative serious: 1 patientsex: 2 drugs: AFLIBERCEPT, HEPARIN SODIUM, RANIBIZUMAB reactions: Retinal artery occlusion serious: 1 patientsex: 1 drugs: ASPIRIN, CLOPIDOGREL BISULFATE, WARFARIN reactions: Atrial thrombosis, Device complication, Drug intolerance, Fall, Haemorrhage intracranial, Subarachnoid haemorrhage serious: 1 patientsex: 1 drugs: IPILIMUMAB reactions: Anaemia, Acute kidney injury, Proteinuria, Nephrotic syndrome, Interstitial nephritis, Proteinuria, Synovitis serious: 1 patientsex: 2 drugs: FLUOROURACIL, LEUCOVORIN, OXALIPLATIN reactions: Stress cardiomyopathy serious: 1 patientsex: 2 drugs: PHENYTOIN reactions: Purple glove syndrome serious: 1 patientsex: 2 drugs: ONDANSETRON HYDROCHLORIDE reactions: Dermatitis hyperpigmentative serious: 1 patientsex: 2 drugs: MESALAMINE reactions: Eosinophilic bronchitis serious: 1 patientsex: 2 drugs: AMANTADINE HYDROCHLORIDE, CARBIDOPALEVODOPA, PRAMIPEXOLE, ROTIGOTINE, ROTIGOTINE reactions: Hallucination, Parkinsons disease, Suicide attempt serious: 1 patientsex: 1 drugs: LINEZOLID, RIFAMPIN, VANCOMYCIN reactions: Acute kidney injury, Candida infection, Pneumonia, Rhabdomyolysis serious: 1 patientsex: 1 drugs: ADALIMUMAB, ASPIRIN, BUDESONIDE, CYCLOPHOSPHAMIDE, CYTARABINE, METHYLPREDNISOLONE, PREDNISONE, TOFACITINIB CITRATE, VINCRISTINE reactions: Drug ineffective, Herpes zoster serious: 1 patientsex: 1 drugs: ALPRAZOLAM, DEXMEDETOMIDINE, FLUMAZENIL, MIDAZOLAM HYDROCHLORIDE, PROPOFOL reactions: Agitation, Drug interaction, Drug withdrawal syndrome, Delirium, Intentional product misuse, Psychotic disorder, Pulse absent serious: 1 patientsex: 1 drugs: FINGOLIMOD HYDROCHLORIDE reactions: Fall, Cryptococcal cutaneous infection, Loss of consciousness, Rash maculo-papular, Varicella zoster virus infection serious: 1 patientsex: 2 drugs: AMPHOTERICIN B, POSACONAZOLE reactions: Haemorrhage, Thrombocytopenia serious: 1 patientsex: 2 drugs: LAMOTRIGINE reactions: Exposure during pregnancy serious: 1 patientsex: 2 drugs: ETHAMBUTOL HYDROCHLORIDE, ISONIAZID, PYRIDOXINE, RIFAMPIN reactions: Cerebral tuberculoma, Hemiparesis serious: 1 patientsex: 1 drugs: AZATHIOPRINE, METHYLPREDNISOLONE, PREDNISOLONE reactions: Drug ineffective, Off label use serious: 1 patientsex: 1 drugs: ACYCLOVIR, ALEMTUZUMAB, CYCLOSPORINE, METHOTREXATE, MYCOPHENOLATE MOFETIL reactions: Gamma-herpesvirus infection, Post transplant lymphoproliferative disorder serious: 1 patientsex: 1 drugs: APIXABAN, DILTIAZEM, METOPROLOL, VALPROIC ACID reactions: Bradycardia, Drug ineffective serious: 1 patientsex: 1 drugs: ANAKINRA, METHYLPREDNISOLONE, HEPARIN SODIUM, LOPINAVIRRITONAVIR reactions: Off label use serious: 1 patientsex: 1 drugs: CYCLOSPORINE, METHYLPREDNISOLONE, PREDNISOLONE, TACROLIMUS reactions: Acute kidney injury, Chronic kidney disease, Hepatic fibrosis, Hepatic function abnormal, Portal fibrosis serious: 1 patientsex: 2 drugs: AZATHIOPRINE, DAPSONE, CYCLOSPORINE, INFLIXIMAB, METHOTREXATE, MYCOPHENOLATE MOFETIL, PREDNISONE, TACROLIMUS reactions: Drug ineffective, Drug resistance serious: 2 patientsex: 2 drugs: ONDANSETRON reactions: Exposure during pregnancy serious: 1 patientsex: 1 drugs: CISPLATIN, DEXAMETHASONE, GEMCITABINE HYDROCHLORIDE, PALONOSETRON reactions: Erythema, Pain, Skin necrosis serious: 1 patientsex: 1 drugs: FLUOROURACIL, LEUCOVORIN, OXALIPLATIN, PANITUMUMAB reactions: Cholangitis, Drug ineffective, Off label use, Product use in unapproved indication serious: 2 patientsex: 2 drugs: METFORMIN HYDROCHLORIDE reactions: Exposure during pregnancy serious: 1 patientsex: 1 drugs: AMIKACIN, AMOXICILLINCLAVULANIC ACID, CYCLOSERINE, CLARITHROMYCIN, ETHAMBUTOL HYDROCHLORIDE, ISONIAZID, MOXIFLOXACIN, PYRAZINAMIDE, RIFAMPIN, SULFAMETHOXAZOLETRIMETHOPRIM reactions: Depression, Drug resistance serious: 2 patientsex: 1 drugs: DORZOLAMIDETIMOLOL, IBUPROFEN, LIRAGLUTIDE, LORCASERIN, LOTEPREDNOL, PREDNISONE reactions: Drug ineffective serious: 1 patientsex: 2 drugs: TERBINAFINE reactions: Acute kidney injury serious: 1 patientsex: 2 drugs: LOPERAMIDE HYDROCHLORIDE reactions: Cardiac arrest, Drug abuse, Overdose, Torsade de pointes, Ventricular fibrillation serious: 1 patientsex: 1 drugs: AMLODIPINE BESYLATE, IMIDAPRIL, GLIMEPIRIDE, METFORMIN HYDROCHLORIDE, IPRAGLIFLOZIN, OMEPRAZOLE, TAMSULOSIN HYDROCHLORIDE, VALACYCLOVIR HYDROCHLORIDE reactions: Abdominal pain, Aspartate aminotransferase increased, Blood glucose increased, Blood bilirubin decreased, Blood glucose increased, Blood urea increased, Blood pressure increased, Blood glucose decreased, Blood glucose increased, Blood glucose increased, Blood urea increased, Blood pressure decreased, Blood glucose increased, Blood glucose decreased, Blood pressure increased, Blood glucose increased, Blood glucose decreased, Blood pressure systolic increased, Blood glucose increased, Blood glucose increased, Blood pressure systolic decreased, Blood glucose increased, Blood glucose increased, Blood glucose decreased, Blood pressure systolic increased, Blood glucose increased, Blood glucose increased, Blood glucose increased, Blood glucose increased, Blood glucose increased, Blood glucose increased, Blood glucose increased, Blood glucose increased, Blood serious: 1 patientsex: 1 drugs: AMLODIPINE BESYLATE, METOPROLOL, MYCOPHENOLIC ACID, PREDNISONE, TACROLIMUS reactions: Biliary increased, Mania, Neurotoxicity serious: 1 patientsex: 2 drugs: DABIGATRAN ETEXILATE MESYLATE reactions: Acute coronary syndrome, Atrial fibrillation, Cerebral infarction, Deep vein thrombosis, Ecchymosis, Graft versus host disease in skin, Pseudoaneurysm serious: 1 patientsex: 2 drugs: CISPLATIN, DOXORUBICIN, FLUOROURACIL, VINCRISTINE reactions: Neuropathy peripheral, Neutropenia, Pyrexia, Sensory neuropathy serious: 1 patientsex: 2 drugs: METHOTREXATE, PREDNISOLONE reactions: Epstein-Barr virus positive mucocutaneous ulcer, Lymphoproliferative disorder serious: 1 patientsex: 2 drugs: AZACITIDINE reactions: Hypersensitivity, Hyperaemia, Injection site hyperaemia serious: 1 patientsex: 1 drugs: AMPHOTERICIN B, MEROPENEM, VORICONAZOLE reactions: Acute respiratory failure, Nausea, Vomiting serious: 1 patientsex: 1 drugs: APIXABAN, INSULIN NOS, POLYETHYLENE GLYCOL 3350 reactions: Septic shock serious: 1 patientsex: 1 drugs: DOLUTEGRAVIR, EMTRICITABINE, TENOFOVIR DISOPROXIL FUMARATE reactions: Immune reconstitution inflammatory syndrome serious: 1 patientsex: 2 drugs: ATORVASTATIN CALCIUM reactions: Myasthenia gravis serious: 1 patientsex: 1 drugs: BEVACIZUMAB, FLUOROURACIL, LEUCOVORIN, OXALIPLATIN reactions: Intestinal perforation serious: 1 patientsex: 1 drugs: AMPICILLIN, AMPICILLIN SODIUMSULBACTAM SODIUM, ISAVUCONAZOLE, PIPERACILLIN SODIUMTAZOBACTAM SODIUM, VANCOMYCIN reactions: Drug ineffective, Mucormycosis serious: 1 patientsex: 2 drugs: BUPIVACAINE, FENTANYL, OXYTOCIN reactions: Foetal distress syndrome, Uterine hypertonia serious: 1 patientsex: 2 drugs: CYCLOPHOSPHAMIDE, DOXORUBICIN, ETOPOSIDE, PREDNISOLONE, VINCRISTINE reactions: Cellulitis, Pancytopenia, Pneumonia, Neuropathy peripheral, Pancytopenia, Vulvovaginitis serious: 1 patientsex: 1 drugs: ASPIRIN, DIAZEPAM, MORPHINE, NITROGLYCERIN, PROPOFOL, SCOPOLAMINE reactions: Drug ineffective, Hypotension, Left ventricular dysfunction serious: 1 patientsex: 2 drugs: DOXORUBICIN HYDROCHLORIDE reactions: Febrile neutropenia serious: 1 patientsex: 1 drugs: TIZANIDINE HYDROCHLORIDE reactions: Hypertriglyceridaemia, Pancreatitis acute serious: 2 patientsex: 2 drugs: HUMAN IMMUNOGLOBULIN G, LEVETIRACETAM, OXCARBAZEPINE reactions: Drug ineffective serious: 1 patientsex: 1 drugs: CYCLOPHOSPHAMIDE, DOXORUBICIN, PREDNISOLONE, VINCRISTINE reactions: Pathogen resistance serious: 1 patientsex: 1 drugs: CAPECITABINE, ELOXATIN, OXALIPLATIN reactions: Diahydropyrimidine dehydrogenase deficiency serious: 1 patientsex: 1 drugs: CARBOPLATIN, GEMCITABINEGEMCITABINE HYDROCHLORIDE, NIVOLUMAB, TELMISARTAN reactions: Posterior reversible encephalopathy syndrome serious: 1 patientsex: 1 drugs: BETAMETHASONE, PROGESTERONE reactions: Abdominal pain, Premature labour, Premature rupture of membranes serious: 1 patientsex: 1 drugs: CYCLOPHOSPHAMIDE, METHYLPREDNISOLONE, MYCOPHENOLATE MOFETIL, PREDNISONE, TACROLIMUS reactions: Acute kidney injury, Hypercalcaemia, Hyperplasia of the parathyroid gland serious: 1 patientsex: 1 drugs: VANCOMYCIN reactions: Retinal haemorrhage serious: 1 patientsex: 2 drugs: FLUOROURACIL, IRINOTECAN, LEUCOVORIN, RAMUCIRUMAB reactions: Thrombotic microangiopathy serious: 1 patientsex: 1 drugs: MIGLUSTAT reactions: Gastrointestinal disorder serious: 1 patientsex: 2 drugs: CARBOPLATIN, CYCLOPHOSPHAMIDE, DOXORUBICIN, PACLITAXEL, PEGFILGRASTIM, PACLITAXEL, PACLITAXEL HYDROCHLORIDE, PEGFILGRASTIM, PACLITAXEL, PEGFILGRASTIM, PACLITAXEL, PEGFILGRASTIM, PACLITAXEL, PEGFILGRASTIM, PACLITAXEL, PEGFILGRASTIM, PACLITAXEL, PEGFILGRASTIM, PACLITAXEL, PEGFILGRASTIM, PACLITAXEL, POTASSIUM, POTASSIUM CHLORIDE, POTASSIUM CHLORIDE, POTASSIUM CHLORIDE, POTASSIUM CHLORIDE, POTASSIUM CHLORIDE, POTASSIUM CHLORIDE, POTASSIUM CHLORIDE, POTASSIUM CHLORIDE, POTASSIUM CHLORIDE, POTASSIUM serious: 1 patientsex: 2 drugs: AMLODIPINE BESYLATE, METFORMIN HYDROCHLORIDE, MYCOPHENOLATE MOFETIL, PREDNISOLONE, TACROLIMUS reactions: Acute respiratory distress syndrome, Biliary tract infection, Biliary stenosis, Bile leakage, Biliary tract infection bacterial, C-reactive protein increased, C-reactive protein increased, C-reactive protein increased, C-reactive protein increased, C-reactive protein increased, C-reactive protein increased, C-reactive protein increased, C-reactive protein increased, C-reactive protein increased, C-reactive protein increased, C-reactive protein increased, C-reactive protein increased, C-reactive protein increased, C-reactive protein increased, C-reactive protein increased, C-reactive protein increased, C-reactive protein increased, C-reactive protein increased, C-reactive protein increased, C-reactive protein increased, C-reactive protein increased, C-reactive protein increased, C-reactive protein increased, C-re serious: 1 patientsex: 2 drugs: CYCLOPHOSPHAMIDE, CYTARABINE, DOXORUBICIN, RITUXIMAB, VINCRISTINE reactions: Adenovirus infection, Cystitis haemorrhagic, Hepatitis E, Liver injury serious: 1 patientsex: 2 drugs: AMITRIPTYLINE, BUPROPION, CITALOPRAM HYDROBROMIDE, FLUOXETINE HYDROCHLORIDE, FLUOXETINE HYDROCHLORIDE, LISDEXAMFETAMINE, OLANZAPINE, ZOLPIDEM TARTRATE reactions: Drug intolerance, Drug resistance, Oedema, Treatment failure serious: 1 patientsex: 1 drugs: IBUPROFEN reactions: Duodenal ulcer, Haemophilus infection, Haemoglobin decreased, Haemorrhagic shock, Haemoglobin decreased, Haemoglobin decreased, Haemoglobin decreased, Haemophilus infection, Haemoglobin decreased, Haemophilus infection, Haemophilus infection, Haemophilus infection, Haemophilus infection, Haemophilus infection, Haemophilus infection, Haemophilus infection, Haemophilus infection, Haemophilus infection, Haemophilus infection, Haemophilus infection, Haemophilus infection, Haemophilus infection, Haemophilus infection, Haemophilus infection, Haemophilus infection, Haemophilus infection, Haemophilus infection, Haemophilus infection, Haemophilus infection, Haemophilus infection, Haemophilus infection, Haemophilus infection, Haemophilus infection, Hae serious: 1 patientsex: 1 drugs: AMLODIPINE BESYLATE, CARBIMAZOLE, PROPRANOLOL HYDROCHLORIDE reactions: Drug interaction, Hypotension serious: 1 patientsex: 1 drugs: AZITHROMYCIN ANHYDROUS, HYDROXYCHLOROQUINE, TOCILIZUMAB reactions: Hypoxia, Respiratory disorder, Thrombosis serious: 1 patientsex: 1 drugs: OMBITASVIRPARITAPREVIRRITONAVIRDACLATASVIR, SOFOSBUVIR reactions: Alanine aminotransferase increased, Alanine aminotransferase increased, Alanine aminotransferase increased, Alanine aminotransferase increased, Alanine aminotransferase increased, Alanine aminotransferase increased, Alanine aminotransferase increased, Alanine aminotransferase increased, Alanine aminotransferase increased, Alanine aminotransferase increased, Alanine aminotransferase increased, Alanine aminotransferase increased, Alanine aminotransferase increased, Alanine aminotransferase increased, Alanine aminotransferase increased, Alanine aminotransferase increased, Alanine aminotransferase increased, Alanine aminotransferase increased, Alanine aminotransferase increased, Alanine aminotransferase increased, Alanine aminotransferase increased, Alanine aminotrans serious: 1 patientsex: 1 drugs: BUSULFAN, CYCLOPHOSPHAMIDE, CYCLOSPORINE, FLUDARABINE PHOSPHATE, METHOTREXATE, METHYLPREDNISOLONE, METHYLPREDNISOLONE SODIUM SUCCINATE, METHYLPREDNISOLONE SODIUM SUCCINATE, METHYLPREDNISOLONE SODIUM SUCCINATE, METHYLPREDNISOLONE SODIUM SUCCINATE, METHYLPREDNISOLONE SODIUM SUCCINATE, METHYLPREDNISOLONE SODIUM SUCCINATE, METHYLPREDNISOLONE SODIUM SUCCINATE, METHYLPREDNISOLONE SODIUM SUCCINATE, METHYLPREDNISOLONE SODIUM SUCCINATE, METHYLPREDNISOLONE SODIUM SUCCINATE, METHYLPRED serious: 1 patientsex: 2 drugs: ASPIRIN, HEPARIN SODIUM, NITROGLYCERIN reactions: Cardiac arrest, Pericardial haemorrhage serious: 1 patientsex: 2 drugs: PACLITAXEL, TRASTUZUMAB reactions: Anaphylactoid reaction, Dyspnoea, Hypotension, Organising pneumonia serious: 1 patientsex: 2 drugs: HYDROXYCHLOROQUINE, METHYLPREDNISOLONE reactions: Iron deficiency anaemia, Sarcoidosis serious: 1 patientsex: 1 drugs: PASIREOTIDE reactions: Cushings disease, Drug ineffective, Off label use serious: 1 patientsex: 1 drugs: CYCLOPHOSPHAMIDE, DOXORUBICIN, PREDNISOLONE, RITUXIMAB, VINCRISTINE reactions: Leukopenia, Neutropenia serious: 1 patientsex: 2 drugs: ALBUTEROL, ACETAMINOPHENHYDROCODONE, DEXAMETHASONE, HYDROCODONEHYDROCODONE BITARTRATE, LISINOPRIL, ONDANSETRON, NEBIVOLOL, SIMVASTATIN, SULFAMETHOXAZOLETRIMETHOPRIM, TEMOZOLOMIDE reactions: Aplastic anaemia serious: 1 patientsex: 2 drugs: CYCLOSPORINE, METHYLPREDNISOLONE reactions: Reversible cerebral vasoconstriction syndrome serious: 1 patientsex: 1 drugs: PENICILLIN G BENZATHINE reactions: Jarisch-Herxheimer reaction serious: 1 patientsex: 1 drugs: PROPRANOLOL HYDROCHLORIDE reactions: Abdominal encapsulating peritoneal fibrosis serious: 1 patientsex: 1 drugs: CYCLOPHOSPHAMIDE, INTERFERON GAMMA, INTERLEUKIN, METHYLPREDNISOLONE, PREDNISOLONE, RITUXIMAB reactions: Myocarditis serious: 1 patientsex: 1 drugs: BETAMETHASONE, ERYTHROMYCIN reactions: Foetal exposure during pregnancy, Premature baby serious: 1 patientsex: 1 drugs: ALTEPLASE reactions: Drug ineffective, Haemorrhagic transformation stroke serious: 1 patientsex: 2 drugs: MIGLUSTAT reactions: Drug ineffective, Off label use serious: 1 patientsex: 2 drugs: AZTREONAM, CYTARABINE, MEROPENEM, PIPERACILLIN SODIUMTAZOBACTAM SODIUM, VANCOMYCIN reactions: Alanine aminotransferase increased, Alanine aminotransferase increased, Alanine aminotransferase increased, Aspartate aminotransferase increased, Alanine aminotransferase increased, Alanine aminotransferase increased, Alanine aminotransferase increased, Alanine aminotransferase increased, Alanine aminotransferase increased, Alanine aminotransferase increased, Alanine aminotransferase increased, Alanine aminotransferase increased, Alanine aminotransferase increased, Alanine aminotransferase increased, Alanine aminotransferase increased, Alanine aminotransferase increased, Aspartate aminotransferase increased, Aspartate aminotransferase increased, Aspartate aminotransferase increased, Aspartate aminotransfer serious: 1 patientsex: 2 drugs: DICLOFENAC reactions: Drug interaction, Jaundice serious: 1 patientsex: 1 drugs: IMATINIB reactions: Drug resistance serious: 1 patientsex: 2 drugs: AMLODIPINE BESYLATE, CANDELOTAXEL, LIDOCAINE, PROPOFOL reactions: Atrial fibrillation, Sinus bradycardia, Tachycardia serious: 1 patientsex: 2 drugs: PEGINTERFERON ALFA-2B, RIBAVIRIN reactions: Optic ischaemic neuropathy serious: 1 patientsex: 1 drugs: CEFTRIAXONE, DEXAMETHASONE, VANCOMYCIN reactions: Drug ineffective serious: 1 patientsex: 1 drugs: FLUCONAZOLE, KETOCONAZOLE reactions: Anaphylactic reaction, Dehydration, Hypotension, Nausea, Tinnitus serious: 1 patientsex: 1 drugs: METHYLPREDNISOLONE reactions: Immune-mediated necrotising myopathy serious: 1 patientsex: 1 drugs: CISPLATIN, DOCETAXEL, ERLOTINIB, GEFITINIB, PACLITAXEL reactions: Neutropenia, Myelosuppression, Gastrointestinal disorder serious: 1 patientsex: 1 drugs: AMIODARONE, LIDOCAINE, ONDANSETRON reactions: Electrocardiogram QT prolonged, Torsade de pointes, Ventricular fibrillation serious: 1 patientsex: 2 drugs: CARBOPLATIN, DOCETAXEL, TRASTUZUMAB reactions: Cardiac failure acute serious: 1 patientsex: 1 drugs: EFAVIRENZ, EMTRICITABINE, GANCICLOVIR, TENOFOVIR DISOPROXIL FUMARATE, VALGANCICLOVIR reactions: Cytomegalovirus infection, Immune reconstitution inflammatory syndrome, Intestinal perforation serious: 1 patientsex: 1 drugs: ACETAMINOPHEN, CEFTRIAXONE, FENERTINIDE reactions: Drug interaction, Hepatic failure, Pyrexia serious: 1 patientsex: 1 drugs: CALCITRIOL, CALCIUM CARBONATE, CALCIUM GLUCONATE, ERGOCALCIFEROL, HYDROCHLOROTHIAZIDE, CALCIUM CARBONATE, ZOLEDRONIC ACID reactions: Drug ineffective, Hypocalcaemia, Renal failure, Treatment failure serious: 1 patientsex: 2 drugs: DABIGATRAN ETEXILATE MESYLATE reactions: Device occlusion, Upper gastrointestinal haemorrhage serious: 1 patientsex: 2 drugs: METHOTREXATE reactions: Bone marrow failure serious: 1 patientsex: 2 drugs: METRONIDAZOLE reactions: Toxic encephalopathy serious: 1 patientsex: 2 drugs: AZATHIOPRINE, BASILIXIMAB, GLIPIZIDE, PIOGLITAZONE, PREDNISOLONE, TACROLIMUS reactions: Abscess limb, Diabetes mellitus, Scedosporium infection serious: 1 patientsex: 1 drugs: ACYCLOVIR, CYCLOSPORINE, MEROPENEM, MYCOPHENOLATE MOFETIL reactions: Burkholderia pseudomallei infection, Malignant neoplasm progression serious: 1 patientsex: 2 drugs: LAMOTRIGINE, LEVETIRACETAM reactions: Cholecystitis, Drug reaction with eosinophilia and systemic symptoms serious: 1 patientsex: 1 drugs: TACROLIMUS reactions: Proteinuria serious: 1 patientsex: 1 drugs: ETOPOSIDE reactions: Acute hepatic failure, Hepatic encephalopathy, Multiple organ dysfunction syndrome serious: 1 patientsex: 1 drugs: CERTOLIZUMAB PEGOL reactions: Thrombotic microangiopathy serious: 1 patientsex: 2 drugs: CLONAZEPAM, ZOLPIDEM TARTRATE reactions: Bundle branch block right, Drug dependence, Drug withdrawal syndrome, Irritability, Irritability, Psychomotor hyperactivity, Tremor serious: 1 patientsex: 2 drugs: ACETAMINOPHEN, FAMOTIDINE, TIZANIDINE reactions: Cystitis haemorrhagic serious: 1 patientsex: 2 drugs: CARBOPLATIN, OLAPARIB reactions: Cognitive disorder, Hyponatraemia, Thrombocytopenia serious: 1 patientsex: 1 drugs: METHADONE HYDROCHLORIDE reactions: Accidental exposure to product by child, Hypotension, Intentional overdose, Miosis, Respiratory depression, Suicide attempt, Toxicity to various agents serious: 1 patientsex: 2 drugs: ANASTROZOLE, CYCLOPHOSPHAMIDE, DOXORUBICIN, PACLITAXEL, TRASTUZUMAB reactions: Nausea serious: 1 patientsex: 2 drugs: LAMOTRIGINE, OXCARBAZEPINE reactions: Cognitive disorder, Drug interaction, Epilepsy, Nausea, Off label use, Product use in unapproved indication, Seizure, Toxicity to various agents serious: 1 patientsex: 1 drugs: DOCETAXEL reactions: Deep vein thrombosis, Oesophageal necrosis, Oesophageal candidiasis, Oesophageal fistula serious: 1 patientsex: 2 drugs: ALENDAZOLE reactions: Dipylidiasis serious: 1 patientsex: 2 drugs: DOCUSATE SODIUM, FUROSEMIDE, ROSUVASTATIN reactions: Acute kidney injury, Metabolic acidosis, Renal tubular acidosis serious: 2 patientsex: 2 drugs: IVABRADINE reactions: Off label use serious: 1 patientsex: 2 drugs: CARBAMAZEPINE, FOLIC ACID, VALPROIC ACID reactions: Baller-Gerold syndrome, Exposure during pregnancy serious: 1 patientsex: 1 drugs: AZULFIDINE, AZATHIOPRINE, HYDROMORPHONE, INFLIXIMAB, SOLUMERIDE reactions: Bacteraemia, Abdominal distension, Ascites, Clostridium difficile infection, Gastrointestinal perforation, Nausea, Pseudomembranous colitis, Small intestinal obstruction, Tachycardia serious: 1 patientsex: 1 drugs: CYCLOSPORINE, INFLIXIMAB, METHOTREXATE, PREDNISONE, RITUXIMAB reactions: Chorioretinopathy, Drug ineffective, Off label use serious: 1 patientsex: 1 drugs: PREDNISOLONE reactions: Cerebral sinus thrombosis, Haematuria serious: 1 patientsex: 2 drugs: TAPENTADOL HYDROCHLORIDE reactions: Exposure during pregnancy, Serotonin syndrome serious: 1 patientsex: 1 drugs: DICLOFENAC reactions: Stevens-Johnson syndrome serious: 1 patientsex: 2 drugs: ASCORBIC ACID, CLONAZEPAM, FERROUS FUMARATE, OLANZAPINE reactions: Restless legs syndrome serious: 1 patientsex: 2 drugs: ASPIRIN, CARVEDILOL, ENALAPRIL, FOLIC ACID, FUROSEMIDE, METHOTREXATE, SIMVASTATIN reactions: Febrile neutropenia, Mucocutaneous haemorrhage, Pancytopenia, Peripheral swelling serious: 1 patientsex: 2 drugs: ASPIRIN, CLARITHROMYCIN, LYSOZYME HYDROCHLORIDE reactions: Drug eruption, Drug hypersensitivity serious: 1 patientsex: 2 drugs: CHLORPROMAZINE, HALOPERIDOL, OLANZAPINE, RISPERIDONE, TRAZODONE HYDROCHLORIDE reactions: Dysphagia, Fatigue, Social disorder, Toxicity to various agents serious: 1 patientsex: 2 drugs: AMOXICILLIN, CEFTRIAXONE, PROBENECID reactions: Jarisch-Herxheimer reaction, Hyperemesis gravidarum serious: 1 patientsex: 2 drugs: ADALIMUMAB, CYCLOSPORINE, HEPARIN SODIUM, MYCOPHENOLIC ACID, OMEPRAZOLE, PREDNISONE, RANITIDINE, WARFARIN reactions: Drug intolerance, Drug intolerance, Drug intolerance, Gastrointestinal disorder, Off label use, Product use in unapproved indication serious: 1 patientsex: 1 drugs: LEVETIRACETAM reactions: Acute kidney injury, Nephropathy toxic serious: 1 patientsex: 2 drugs: GUAIFENESIN, PHYTONADIONE HYDROCHLORIDE, THYROXINE reactions: Angle closure crisis serious: 1 patientsex: 2 drugs: BEVACIZUMAB, DEXAMETHASONE, TEMOZOLOMIDE reactions: Drug ineffective, Gadolinium adenoma, Neurological decompensation, Treatment failure serious: 1 patientsex: 1 drugs: AZATHIOPRINE, CYCLOSPORINE, MYCOPHENOLATE MOFETIL, TACROLIMUS reactions: Kaposis sarcoma serious: 1 patientsex: 2 drugs: AMLODIPINE BESYLATE, ASPIRIN, CHLORPHENIRAMINE, LIDOCAINE reactions: Anaphylactic reaction serious: 1 patientsex: 1 drugs: FLUOROURACIL, LEUCOVORIN, PACLITAXEL reactions: Bone disorder, Gingival bleeding, Gingival swelling, Oral disorder, Periodontitis serious: 1 patientsex: 2 drugs: BORTEZOMIB, DEXAMETHASONE reactions: Diarrhoea serious: 1 patientsex: 2 drugs: HYDROXYUREA, NILOTINIB reactions: Neutropenia, Off label use, QT prolonged serious: 1 patientsex: 1 drugs: DICETAMINE reactions: Gastrointestinal haemorrhage serious: 1 patientsex: 1 drugs: CYCLOPHOSPHAMIDE, CYTARABINE, DAUNORUBICIN, IFOSFAMIDE, METHOTREXATE, VINDESINE reactions: Posterior reversible encephalopathy syndrome serious: 1 patientsex: 2 drugs: ZONISAMIDE, VALPROIC ACID reactions: Myoclonic epilepsy with ragged red fibres serious: 1 patientsex: 1 drugs: ASPIRIN, ATORVASTATIN, CARVEDILOL, CLOPIDOGREL BISULFATE, DIGOXIN, ISOSORBIDE MONONITRATE, PIPERACILLIN SODIUMTAZOBACTAM SODIUM, TORSEMIDE, VIVBRADINE reactions: Bradycardia, Drug interaction, Hypotension, Metabolic alkalosis, Orthostatic hypotension, Pyrexia, Respiratory alkalosis, Respiratory alkalosis, Toxicity to various agents serious: 1 patientsex: 1 drugs: CISPLATIN, ASPIRIN reactions: Colitis serious: 1 patientsex: 1 drugs: ASPIRIN, DASATINIB, IMATINIB MESYLATE, METHYLPREDNISOLONE, PREDNISONE, VINCRISTINE reactions: Diabetes mellitus, Drug intolerance, Pancreatitis, Toxicity to various agents serious: 1 patientsex: 1 drugs: FLUCONAZOLE reactions: Alopecia, Chloroma, Drug ineffective, Erosis, Xerosis, Skin enlargement serious: 1 patientsex: 1 drugs: CIPROFLOXACIN reactions: Clostridium difficile infection, Klebsiella infection, Septic shock serious: 1 patientsex: 2 drugs: CYCLOPHOSPHAMIDE, DOXORUBICIN, PREDNISONE, RITUXIMAB, VINCRISTINE reactions: Neutropenia serious: 1 patientsex: 2 drugs: IMATINIB MESYLATE reactions: Fatigue, Off label use serious: 1 patientsex: 1 drugs: PEMBROLIZUMAB reactions: Colitis, Deep vein thrombosis, Hemiplegia, Pneumonitis, Renal infarction, Splenic infarction, Vasculitis serious: 1 patientsex: 1 drugs: PAZOPANIB reactions: Drug-induced liver injury serious: 1 patientsex: 1 drugs: LEVETIRACETAM reactions: Condition aggravated, Dystonia, Muscle spasms, Muscle rigidity, Muscle twitching, Muscle twitching, Muscle twitching, Muscle spasms, Muscle twitching, Muscle spasms, Muscle spasms, Muscle spasms, Muscle spasms, Muscle spasms, Muscle spasms, Muscle spasms, Muscle spasms, Muscle spasms, Muscle spasms, Muscle spasms, Muscle spasms, Muscle spasms, Muscle spasms, Muscle spasms, Muscle spasms, Muscle spasms, Muscle spasms, Muscle spasms, Muscle spasms, Muscle spasms, Muscle spasms, Muscle spasms, Muscle spasms, Muscle spasms, Muscle spasms serious: 1 patientsex: 1 drugs: BICALUTAMIDE, DEGARELIX, GOSERELIN, LEUPROLIDE ACETATE reactions: Drug ineffective, Leydig cell carcinoma serious: 1 patientsex: 1 drugs: ASPIRIN, BISOPROLOL, CALCIUM CARBONATE, CHOLECALCIFEROL, CYCLOPHOSPHAMIDE, HYDROCORTISONE, METHYLPREDNISOLONE, METHYLPREDNISOLONE SODIUM SUCCINATE, METHYLPREDNISOLONE ACETATE, METHYLPREDNISOLONE SODIUM SUCCINATE, METHYLPREDNISOLONE SODIUM SUCCINATE, METHYLPREDNISOLONE SODIUM SUCCINATE, METHYLPREDNISOLONE SODIUM SUCCINATE, METHYLPREDNISOLONE SODIUM SUCCINATE, METHYLPREDNISOLONE SODIUM SUCCINATE, METHYLPREDNISOLONE SODIUM SUCCINATE, METHYLPREDNISOLONE SODIUM SUCCINATE, METHYLP serious: 1 patientsex: 2 drugs: METHYLPREDNISOLONE reactions: Aspergillus infection, Bone perforation, Gait disturbance, Mouth ulceration, Mouth haemorrhage, Mouth hole, Mouth swelling, Mouth ulceration, Mouth perforation, Mouth oedema, Mouth ulceration, Mouth swelling, Mouth ulceration, Mouth perforation, Mouth ulceration, Mouth ulceration, Mouth ulceration, Mouth ulceration, Mouth ulceration, Mouth ulceration, Mouth ulceration, Mouth ulceration, Mouth ulceration, Mouth ulceration, Mouth ulceration, Mouth ulceration, Mouth ulceration, Mouth ulceration, Mouth ulceration, Mouth ulceration, Mouth ulceration, Mouth ulceration, Mouth ulceration, Mouth ulceration, Mouth ulceration, Mouth ulceration, Mouth ulceration, Mouth ulceration, Mouth ulceration, Mouth ulceration, Mouth ulceration, Mouth ulceration, Mouth ulceration, Mouth ulceration, Mouth ulceration, Mouth serious: 1 patientsex: 2 drugs: MEROPENEM, NITROFURANTOIN, PIPERACILLIN SODIUMTAZOBACTAM SODIUM, VANCOMYCIN reactions: Clostridium difficile infection, Leukocytosis serious: 1 patientsex: 1 drugs: IMATINIB MESYLATE reactions: Acute myeloid leukaemia serious: 1 patientsex: 1 drugs: CLINDAMYCIN, IMIPENEM, MEROPENEM, SULFAMETHOXAZOLETRIMETHOPRIM reactions: Drug intolerance serious: 1 patientsex: 1 drugs: HYDROCORTISONE, LEVOTHYROXINE, PREDNISONE reactions: Adrenocorticotropic hormone increased, Cushings disease serious: 1 patientsex: 2 drugs: CYCLOPHOSPHAMIDE, METHYLPREDNISOLONE, NITISINONE reactions: Hepatocellular carcinoma serious: 1 patientsex: 1 drugs: BEVACIZUMAB, PROPARACAINE HYDROCHLORIDE reactions: Endophthalmitis, Off label use, Product use issue serious: 1 patientsex: 2 drugs: ACETAMINOPHEN, CELECOXIB, DEXAMETHASONE, FENTANYL, GABAPENTIN, HYDROMORPHONE, METHADONE HYDROCHLORIDE reactions: Drug interaction, Hallucination, Meningitis meningoencephalitis, Urinary tract infection bacterial serious: 1 patientsex: 2 drugs: DIAZEPAM, FLUOXETINE HYDROCHLORIDE, METHOTREXATE, MIANSERIN, SERTRALINE HYDROCHLORIDE reactions: Drug interaction, Drug level decreased, Drug level increased, Drug resistance, Hypotension, Orthostatic hypotension, Psychomotor retardation, Psychomotor retardation, Psychomotor retardation, Psychomotor retardation, Psychomotor retardation, Psychomotor retardation, Psychomotor retardation, Psychomotor retardation, Psychomotor retardation, Psychomotor retardation, Psychomotor retardation, Psychomotor retardation, Psychomotor retardation, Psychomotor retardation, Psychomotor retardation, Psychomotor retardation, Psychomotor retardation, Psychomotor retardation, Psychomotor retardation, Psychomotor retardation, Psychomotor retardation, Psychomotor retardation, Psychomotor retardation, Psychomotor retardation, Psychomotor retardation, Psychomotor retardation, Psychomotor retardation, Psychomotor retardation, Psychomotor retardation, Psychomotor retardation, Psychomotor retardation, Psychomotor retardation, Psychomotor retardation, Psychomotor retardation, Psychomotor retardation, Psychomotor retardation, serious: 1 patientsex: 2 drugs: BUPIVACAINE, DIMETHYL FUMARATE, MORPHINE, SODIUM CHLORIDE reactions: Disease recurrence serious: 1 patientsex: 1 drugs: AZATHIOPRINE, INFLIXIMAB reactions: Intestinal tuberculosis serious: 1 patientsex: 2 drugs: HYDROMORPHONE, MORPHINE SULFATE reactions: Toxic encephalopathy serious: 1 patientsex: 2 drugs: CLONIDINE, AROTINOLOL, CLONIDINE HYDROCHLORIDE, CLONIDINE HYDROCHLORIDE, ERYTHROPOIETIN, LACIDIPINE, OLMESARTAN, NITRIPIPINE, TELMISARTAN, TERAZOSIN reactions: Adrenal gland hyperplasia serious: 1 patientsex: 1 drugs: DAPTOMYCIN, VANCOMYCIN reactions: Acute kidney injury, Drug-induced liver injury, Toxicity to various agents serious: 1 patientsex: 1 drugs: TESTOSTERONE reactions: Dissociative identity disorder, Hostility, Homicidal ideation, Suicidal ideation serious: 1 patientsex: 1 drugs: ARIPIPRAZOLE, OLANZAPINE, QUETIAPINE reactions: Drug ineffective, Overeating serious: 1 patientsex: 1 drugs: ERLOTINIB, GABAPENTIN, OMEPRAZOLE reactions: Adrenal insufficiency, Malignant neoplasm progression, Metastases to pituitary serious: 1 patientsex: 2 drugs: IPILIMUMAB, NIVOLUMAB reactions: Autoimmune hepatitis, Vitiligo serious: 1 patientsex: 2 drugs: CYCLOPHOSPHAMIDE, DOXORUBICIN, PREDNISOLONE, VINCRISTINE reactions: Condition aggravated, Drug ineffective, Off label use serious: 1 patientsex: 1 drugs: CYCLOPHOSPHAMIDE, DEXAMETHASONE, ETOPOSIDE, HUMAN IMMUNOGLOBULIN G, METHYLPREDNISOLONE, PREDNISOLONE, RITUXIMAB reactions: Drug ineffective, Leukoencephalopathy serious: 1 patientsex: 2 drugs: DIMETHYL FUMARATE reactions: Progressive multifocal leukoencephalopathy serious: 1 patientsex: 2 drugs: BEVACIZUMAB, CARBOPLATIN, PACLITAXEL reactions: Drug resistance serious: 1 patientsex: 1 drugs: FUROSEMIDE reactions: Pancreatitis necrotising serious: 1 patientsex: 2 drugs: AMPHOTERICIN B, POSACONAZOLE reactions: Drug ineffective serious: 1 patientsex: 2 drugs: GEMCITABINE HYDROCHLORIDE reactions: Drug ineffective serious: 1 patientsex: 1 drugs: ASPIRIN, CIPROFLOXACIN, NATAMYCIN, METOPROLOL, SIMVASTATIN, VANCOMYCIN, VORICONAZOLE reactions: Drug ineffective serious: 1 patientsex: 1 drugs: CARBOPLATIN, FLUOROURACIL, LEUCOVORIN, OXALIPLATIN reactions: Oesophagitis serious: 1 patientsex: 1 drugs: ASPIRINCLOPIDOGREL BISULFATE, CEFTRIAXONE SODIUMSULBACTAM SODIUM, ENOXAPARIN, ERYTHROMYCIN, FENTANYL, ENOXAPARIN SODIUM, ERYTHROMYCINMIDAZOLAM HYDROCHLORIDE, ENOXAPARIN SODIUM, ENOXAPARIN SODIUM, FENTANYL, ENOXAPARIN SODIUM, ENOXAPARIN SODIUM, ENOXAPARIN SODIUM, ERYTHROMYCIN, METRONIDAZOLE, PANTOPRAZOLE, POTASSIUM CHLORIDE, SEVOFLURANE, SEVOFLURANE, VECURONIUM BROMIDE reactions: Drug interaction, Drug level increased, Drug interaction, Haemodynamic instability, Hypoxia, Ileus paralytic, Respiratory distress, Respiratory distress, Tachy serious: 1 patientsex: 1 drugs: ABOBOTULINUM TOXIN TYPE A reactions: Myasthenia gravis, Off label use, Product use in unapproved indication serious: 1 patientsex: 2 drugs: CILASTATIN SODIUMIMIPENEM, VENLAFAXINE HYDROCHLORIDE reactions: Cardiac failure, Cardiomyopathy, Interstitial lung disease serious: 1 patientsex: 1 drugs: INSULIN ASPART, INSULIN DETEMIR reactions: Hypoglycaemic coma serious: 1 patientsex: 2 drugs: CYCLOPHOSPHAMIDE, DOXORUBICIN, PREDNISOLONE, VINCRISTINE reactions: Alopecia, Asthenia, Bone pain, Dyspnoea, Fatigue, Hepatic enzyme increased, Hepatic function abnormal, Metastases to lung, Nausea, Neutropenia, Off label use, Thrombocytopenia, Vomiting serious: 1 patientsex: 2 drugs: PREDNISONE reactions: Growth hormone decreased serious: 1 patientsex: 2 drugs: DISULFIRAM reactions: Neuropathy peripheral serious: 1 patientsex: 1 drugs: NAPROXEN, SULFASALAZINE reactions: Bone marrow failure, Pancytopenia serious: 1 patientsex: 2 drugs: AXITINIB, ESTAZOLAM, ETIZOLAM, LANSOPRAZOLE, NIFEDIPINE, SUNITINIB MALATE reactions: Bradycardia, Hyperkalaemia, Metabolic acidosis, Renal impairment, Sinus arrest serious: 1 patientsex: 2 drugs: CARBAMAZEPINE, OXCARBAZEPINE, PAROXETINE, VALPROIC ACID reactions: Drug eruption, Rash pruritic serious: 1 patientsex: 2 drugs: BUPROPION, ESCITALOPRAM OXALATE, HYAOCYAMINE SULFATE, OMEPRAZOLE, TESTOSTERONE CYPIONATE reactions: Cystic pancreatic neoplasm serious: 1 patientsex: 2 drugs: METHYLPREDNISOLONE, INTERFERON reactions: Raynaud syndrome serious: 1 patientsex: 1 drugs: ASPIRIN, HEPARIN SODIUM reactions: Drug ineffective serious: 1 patientsex: 2 drugs: ALPRAZOLAM, HYDROCHLOROTHIAZIDE, MELOXICAM, OMEPRAZOLE, SIMVASTATIN reactions: Acute generalised exanthematous pustulosis serious: 1 patientsex: 2 drugs: BEVACIZUMAB, ASPIRIN, BUDESONIDE, CYCLOPHOSPHAMIDE, CYTARABINE, METHYLPREDNISOLONE, METHYLPREDNISOLONE SODIUM SUCCINATE, METHYLPREDNISOLONE ACETATE, METHYLPREDNISOLONE SODIUM SUCCINATE, METHYLPREDNISOLONE ACETATE, METHYLPREDNISOLONE SODIUM SUCCINATE, METHYLPREDNISOLONE ACETATE, METHYLPREDNISOLONE SODIUM SUCCINATE, METHYLPREDNISOLONE SODIUM SUCCINATE, METHYLPREDNISOLONE SODIUM SUCCINATE, METHYLPREDNISOLONE SODIUM SUCCINATE, METHYLPREDNISOLONE SODIUM SUCCINATE, METHYLPREDNISOLONE serious: 1 patientsex: 1 drugs: MERCAPTOPURINE, METHOTREXATE, VINCRISTINE reactions: Pneumonitis serious: 1 patientsex: 1 drugs: PIPERACILLIN SODIUMTAZOBACTAM SODIUM reactions: Drug interaction, Electrocardiogram QT prolonged, Hepatic function abnormal serious: 1 patientsex: 1 drugs: HALOPERIDOL, OLANZAPINE, SERTRALINE HYDROCHLORIDE, RISPERIDONE reactions: Hypotension, Paranoia serious: 1 patientsex: 2 drugs: MIDAZOLAM HYDROCHLORIDE reactions: Hepatitis toxic serious: 1 patientsex: 1 drugs: BENDAMUSTINE HYDROCHLORIDE, FOSCARNET, GANCICLOVIR, RITUXIMAB, VALGANCICLOVIR reactions: Cytomegalovirus infection, Encephalopathy, Gastritis, Neutropenia, Ocular oedema, Retinitis, Staphylococcal enterotoxin B infection, Visual acuity reduced serious: 1 patientsex: 1 drugs: HYDROXYCHLOROQUINE, OSELTAMIVIR reactions: Accidental overdose, Electrocardiogram QT prolonged, Sinus bradycardia serious: 1 patientsex: 2 drugs: LEUPROLIDE ACETATE reactions: Pseudotumour cerebri serious: 1 patientsex: 1 drugs: AZITHROMYCIN ANHYDROUS, CEPHALEXIN, LEVOFLOXACIN, METHYLPREDNISOLONE, MYCOPHENOLATE MOFETIL, PREDNISONE, VANCOMYCIN reactions: Drug ineffective serious: 1 patientsex: 2 drugs: ACETAMINOPHEN, HEPARIN SODIUM, FERROUS SULFATE reactions: Acute lymphocytic leukaemia serious: 1 patientsex: 1 drugs: AMLODIPINE BESYLATE, EPLERENONE, OMBITASVIRPARITAPREVIRRITONAVIR, RIBAVIRIN reactions: Cough, Cough erythematous, Cough suppurative, Cough erythematous, Cough suppurative, Cough erythematous, Cough suppurative, Cough suppurative, Cough suppurative, Cough suppurative, Cough suppurative, Cough suppurative, Cough suppurative, Cough suppurative, Cough suppurative, Cough suppurative, Cough suppurative, Cough suppurative, Cough suppurative, Cough suppurative, Cough suppurative, Cough suppurative, Cough suppurative, Cough suppurative, Cough suppurative, Cough suppurative, C serious: 1 patientsex: 2 drugs: BOTULINUM TOXIN TYPE A reactions: Aortic pseudoaneurysm serious: 1 patientsex: 1 drugs: PEMBROLIZUMAB reactions: Hepatitis, Off label use, Pyrexia, Thrombocytopenia serious: 1 patientsex: 1 drugs: BEDAZILINE MESYLATE, CYCLOPHOSPHAMIDE, DEXAMETHASONE, DOXORUBICIN, ETOPOSIDE, METHOTREXATE, PREDNISOLONE, RITUXIMAB, VINCRISTINE reactions: Arrhythmia, Death, Drug interaction, Electrocardiogram QT prolonged serious: 1 patientsex: 2 drugs: DOXORUBICIN, IFOSFAMIDE, GRANULOCYTE COLONY-STIMULATING FACTOR NOS reactions: Ascites, Bone marrow failure, Febrile neutropenia, Neutropenia, Off label use, Product use in unapproved indication, Product use issue, Product use in unapproved indication serious: 1 patientsex: 1 drugs: AMIODARONE, ESMOLOL SUCCINATE reactions: Drug ineffective, Drug intolerance, Drug resistance, Shock serious: 1 patientsex: 2 drugs: SUNITINIB MALATE reactions: Cardiac toxicity, Drug resistance, Malignant neoplasm progression, Metastases to pelvis, Product use in unapproved indication serious: 1 patientsex: 2 drugs: BETAMETHASONE, ALFAMETILDOPA, ENAPAREN, FUROSEMIDE, HEPARIN SODIUM, SPIRONOLACTONE reactions: Drug ineffective, Exposure during pregnancy serious: 1 patientsex: 2 drugs: AZATHIOPRINE, ADALIMUMAB, MYCOPHENOLIC ACID, PREDNISOLONE reactions: Drug dependence, Drug resistance, Hepatic enzyme increased, Polyarthritis serious: 1 patientsex: 2 drugs: ACETAMINOPHENOXYCODONE HYDROCHLORIDE, DEXLANSOPRAZOLE, MESALAMINE, ONDANSETRON, OXYCODONE, SUMATRIPTAN, TOPIRAMATE reactions: Angle closure glaucoma, Iridotomy, Pupils absent, Pupils afferent, Pupils reversible, Pupils oedema, Pupils oedema peripheral, Pupils reversible, Pupils trabeculated, Visual acuity reduced serious: 1 patientsex: 1 drugs: CEFTRIAXONE, VANCOMYCIN reactions: Drug ineffective, Staphylococcal infection serious: 1 patientsex: 2 drugs: BLEOMYCIN SULFATE, CISPLATIN, ETOPOSIDE reactions: Teratoma serious: 1 patientsex: 2 drugs: CISPLATIN, DOXORUBICIN, PACLITAXEL reactions: Diarrhoea, Hypertension, Polyneuropathy, Stress serious: 1 patientsex: 1 drugs: FLUOXETINE HYDROCHLORIDE, LAMOTRIGINE, KETOROLAC TROMETHAMINE reactions: Tubulointerstitial nephritis serious: 1 patientsex: 1 drugs: CLINDAMYCIN, HYDROXYCHLOROQUINE reactions: Actinomycosis, Meningoencephalitis, Septic shock serious: 1 patientsex: 1 drugs: ACYCLOVIR, CYCLOPHOSPHAMIDE, HUMAN IMMUNOGLOBULIN G, LEVETIRACETAM, METHYLPREDNISOLONE, OLANZAPINE, PIPERACILLIN SODIUMTAZOBACTAM SODIUM, QUETIAPINE, VALPROIC ACID reactions: Drug ineffective, Hypotension serious: 1 patientsex: 2 drugs: METHYLPREDNISOLONE, MYCOPHENOLATE MOFETIL, TACROLIMUS reactions: Diarrhoea, Nonalcoholic steatohepatitis, Steatohepatitis serious: 1 patientsex: 1 drugs: ACYCLOVIR, CEFEPIME HYDROCHLORIDE, PREDNISONE reactions: Toxic encephalopathy serious: 2 patientsex: 2 drugs: AMLODIPINE BESYLATE, ATORVASTATIN, LISINOPRIL, METFORMIN HYDROCHLORIDE reactions: Drug ineffective serious: 1 patientsex: 1 drugs: AMLODIPINE BESYLATE, CLOPIDOGREL BISULFATE, ROSUVASTATIN, VALSARTAN reactions: Optic atrophy, Treatment failure serious: 1 patientsex: 1 drugs: MERCAPTOPURINE, METHOTREXATE reactions: Immune thrombocytopenic purpura serious: 1 patientsex: 2 drugs: DEXAMETHASONE, LACOSAMIDE, LEVETIRACETAM, METHOTREXATE, MANNITOL, ONDANSETRON, METOCLOPRAMIDE, ONDANSETRON HYDROCHLORIDE, METHOTREXATE SODIUM, ONDANSETRON HYDROCHLORIDE, VALPROIC ACID reactions: Drug ineffective serious: 1 patientsex: 2 drugs: CYCLOPHOSPHAMIDE, PREDNISOLONE, TACROLIMUS, VALACYCLOVIR HYDROCHLORIDE, VORICONAZOLE reactions: Chronic kidney disease, Drug ineffective, Mycobacterium abscessus infection, Peritonitis serious: 1 patientsex: 2 drugs: RITUXIMAB reactions: Anaemia, Drug ineffective, Gastrointestinal haemorrhage, Off label use, Product use in unapproved indication serious: 1 patientsex: 1 drugs: CABERGOLINE, MIRTAZAPINE, QUETIAPINE reactions: Drug resistance, Drug level increased, Drug level increased, Ischaemic stroke, Psychotic disorder serious: 1 patientsex: 1 drugs: CRIZOTINIB reactions: Diffuse alveolar damage, Organising pneumonia serious: 1 patientsex: 2 drugs: POMALIDOMIDE, SULFAMETHOXAZOLETRIMETHOPRIM reactions: Disseminated Varicella zoster virus infection serious: 1 patientsex: 2 drugs: CARBOPLATIN, PEMETREXED reactions: Oesophagitis serious: 1 patientsex: 1 drugs: CYCLOPHOSPHAMIDE, DOXORUBICIN, PREDNISOLONE, VINCRISTINE reactions: Drug ineffective serious: 1 patientsex: 1 drugs: DAUNORUBICIN, TRETINOIN reactions: Myocarditis serious: 1 patientsex: 2 drugs: ATENOLOL, LORAZEPAM, MIRTAZAPINE, METFORMIN HYDROCHLORIDE reactions: Intentional overdose, Lactic acidosis serious: 1 patientsex: 1 drugs: FILGRASTIM reactions: Acute myeloid leukaemia, Neutropenia serious: 1 patientsex: 2 drugs: AZATHIOPRINE, INFLIXIMAB, METHOTREXATE, PREDNISONE, RITUXIMAB reactions: Rheumatoid nodule serious: 1 patientsex: 1 drugs: CLOZAPINE, LITHIUM, SERTRALINE HYDROCHLORIDE, VALPROIC ACID reactions: Drug ineffective, Hypochondriasis serious: 1 patientsex: 2 drugs: AMLODIPINE BESYLATE, ASPIRIN, CLOPIDOGREL BISULFATE, FONDAPARINUX, GLYCERIN, WARFARIN reactions: Rash petechial serious: 1 patientsex: 1 drugs: IBRUTINIB, PREDNISONE reactions: Central nervous system aspergillosis serious: 1 patientsex: 2 drugs: AZACITIDINE, HYDROXYUREA, IMATINIB, INTERFERON BETA-1A reactions: Myelodysplastic syndrome, Treatment failure serious: 1 patientsex: 1 drugs: HEPARIN SODIUM, PROPOFOL reactions: Ischaemic priapism serious: 1 patientsex: 1 drugs: AMLODIPINE BESYLATE, CARVEDILOL, DIGOXIN, FUROSEMIDE, RAMIPRIL, SPIRONOLACTONE, VALSARTAN reactions: Drug ineffective, Mediastinal fluid collection, Off label use serious: 2 patientsex: 2 drugs: HYDROXYZINE HYDROCHLORIDE, METHYLPREDNISOLONE reactions: Drug ineffective serious: 2 patientsex: 2 drugs: FIBRITALOL, LIPIDIL ONE, OMEPRAZOLE reactions: Off label use serious: 1 patientsex: 2 drugs: CEPHALEXIN reactions: Hypernatraemia, Hypokalaemia, Paralysis, Renal tubular acidosis, Tubulointerstitial nephritis serious: 1 patientsex: 1 drugs: EVEROLIMUS, SORAFENIB reactions: Drug resistance serious: 1 patientsex: 1 drugs: CYCLOPHOSPHAMIDE, VINCRISTINE reactions: Candida infection, Neutropenia, Sepsis serious: 1 patientsex: 2 drugs: CARBIDOPALEVODOPA, PRAMIPEXOLE reactions: Complex regional pain syndrome, Dystonia serious: 1 patientsex: 1 drugs: CISPLATIN, GEMCITABINEGEMCITABINE HYDROCHLORIDE reactions: Thrombocytopenia serious: 1 patientsex: 1 drugs: AXITINIB, PEMBROLIZUMAB, SUNITINIB MALATE reactions: Blindness, Retinal detachment, Uveitis serious: 1 patientsex: 1 drugs: SORAFENIB reactions: Skin toxicity serious: 1 patientsex: 1 drugs: CISPLATIN reactions: Aggression, Agitation, Aggression, Aggression, Aggression, Aggression, Aggression, Aggression, Aggression, Aggression, Aggression, Aggression, Aggression, Aggression, Aggression, Aggression, Aggression, Aggression, Aggression, Aggression, Aggression, Aggression, Aggression, Aggression, Aggression, Aggression, Aggression, Aggression, Aggression, Aggression, Aggression, Aggression, Aggression, Aggression, Aggression, Aggression, Aggression, Aggression, Aggression, Aggression, Aggression, Aggression, Aggression, Aggression, Aggression, Aggression, Aggression, Aggression, Aggression, Aggression, Aggression, Aggression, Aggression, Aggression, Aggression, Aggression, Aggression, Aggression, Aggression, Aggression, Aggression, Aggression, Aggression, Aggression, Aggression, Aggression, Aggression, Aggression, Aggression, Aggression, Aggression, Aggression, Aggression, Aggression, Aggression, Aggression, Aggression, Aggression, Aggression, Ag serious: 1 patientsex: 1 drugs: ASPIRIN, CYPROHEPTADINE, METHYLPREDNISOLONE, METHYLPREDNISOLONE SODIUM SUCCINATE, METHYLPREDNISOLONE ACETATE, METHYLPREDNISOLONE SODIUM SUCCINATE, METHYLPREDNISOLONE ACETATE, METHYLPREDNISOLONE SODIUM SUCCINATE, METHYLPREDNISOLONE SODIUM SUCCINATE, METHYLPREDNISOLONE SODIUM SUCCINATE, METHYLPREDNISOLONE SODIUM SUCCINATE, METHYLPREDNISOLONE SODIUM SUCCINATE, METHYLPREDNISOLONE SODIUM SUCCINATE, METHYLPREDNISOLONE SODIUM SUCCINATE, METHYLPREDNISOLONE SODIUM SUCCINATE, METHYLPRED serious: 1 patientsex: 1 drugs: PREDNISONE reactions: Hepatitis B reactivation serious: 1 patientsex: 2 drugs: TRIAMCINOLONE reactions: Conjunctival haemorrhage, Embolism, Retinal artery occlusion, Retinal vascular disorder, Visual acuity reduced serious: 1 patientsex: 2 drugs: METHYLPREDNISOLONE reactions: Lymphopenia serious: 1 patientsex: 2 drugs: ALLOPURINOL, AMIODARONE, AMIODARONE HYDROCHLORIDE, DABIGATRAN ETEXILATE MESYLATE, DILTIAZEM, LEVOTHYROXINE, PANTOPRAZOLE SODIUM, RAMIPRIL, ROSUVASTATIN reactions: Thrombocytopenia serious: 1 patientsex: 2 drugs: CISPLATIN, DOXORUBICIN, PACLITAXEL reactions: Acute kidney injury, Fatigue, Nausea serious: 1 patientsex: 2 drugs: CISPLATIN, DEXAMETHASONE, GEMCITABINEGEMCITABINE HYDROCHLORIDE, RITUXIMAB reactions: Coronary artery vasoconstriction serious: 1 patientsex: 1 drugs: IPILIMUMAB, NIVOLUMAB reactions: Autoimmune encephalopathy, Cerebellar toxicity serious: 1 patientsex: 1 drugs: CAPECITABINE, DALTEPARIN SODIUM, FLUOROURACIL, LEUCOVORIN, OXALIPLATIN, SOTALOL, VALSARTAN reactions: Atrial fibrillation, Dizziness, Flushing, Sinus arrest, Syncope serious: 1 patientsex: 2 drugs: SIROLIMUS reactions: Pseudoneutropenia serious: 1 patientsex: 1 drugs: ATOVAQUONE, PYRIMETHAMINE, SULFADIAZINE reactions: Acute kidney injury, Drug intolerance, Hepatic enzyme increased, Urolithiasis serious: 1 patientsex: 2 drugs: SULFASALAZINE reactions: Neutropenic colitis serious: 1 patientsex: 2 drugs: AMLODIPINE BESYLATE, ISOSORBIDE MONONITRATE, LEVOTHYROXINE, METFORMIN HYDROCHLORIDE, OMEPRAZOLE, RANOLAZINE HYDROCHLORIDE reactions: Acute kidney injury, Bradycardia, Hyperkalaemia, Renal failure serious: 1 patientsex: 1 drugs: CARBOPLATIN, PEMETREXED reactions: Haematotoxicity serious: 1 patientsex: 1 drugs: BENDAMUSTINE HYDROCHLORIDERITUXIMAB reactions: COVID-19 serious: 1 patientsex: 2 drugs: ATORVASTATIN, CLORAZEPATE, DULOXETINE, PREGABALIN, TRAMADOL reactions: Hypertensive crisis, Posterior reversible encephalopathy syndrome serious: 1 patientsex: 2 drugs: PANTOPRAZOLE SODIUM reactions: Haemolytic anaemia serious: 1 patientsex: 1 drugs: ACETAMINOPHEN, CISPLATIN, DEXAMETHASONE, DIMENHYDRINATE, MAGNESIUM SULFATE, METOCLOPRAMIDE, MANNITOL, OMEPRAZOLE, POTASSIUM CHLORIDE, SODIUM CHLORIDE reactions: Hypersensitivity vasculitis serious: 1 patientsex: 2 drugs: AMLODIPINE BESYLATE, CAFFEINE, BUTALBITAL reactions: Alcohol, Intentional overdose, Lactic acidosis, Mental status changes, Nausea, Overdose, Mental status changes, Vomiting serious: 1 patientsex: 1 drugs: CISPLATIN, FLUOROURACIL reactions: Lymph node enlargement serious: 1 patientsex: 1 drugs: GABAPENTIN, IBUPROFEN, SOLIFENACIN reactions: Drug ineffective serious: 1 patientsex: 1 drugs: LINEZOLID, POSACONAZOLE reactions: Drug ineffective serious: 1 patientsex: 1 drugs: DONEPEZIL, PREGABALIN, QUETIAPINE, ROCURONIUM BROMIDE reactions: Drug interaction, Neuromuscular block prolonged serious: 1 patientsex: 1 drugs: AMANTADINE HYDROCHLORIDE, ARIPIPRAZOLE, BENZTROPINE, LORAZEPAM, OLANZAPINE reactions: Confusional state, Pneumonia aspiration serious: 1 patientsex: 1 drugs: BORTEZOMIB, DEXAMETHASONE, LENALIDOMIDE, POMALIDOMIDE reactions: Aphasia, Coma, Neurotoxicity, Sedation serious: 1 patientsex: 1 drugs: AZATHIOPRINE, BUDESONIDE reactions: Drug ineffective, Papilloma viral infection serious: 1 patientsex: 2 drugs: CYCLOPHOSPHAMIDE, EPIRUBICIN, FLUOROURACIL reactions: Neutropenia serious: 1 patientsex: 1 drugs: AMISULPRIDE, CLOZAPINE, LANSOPRAZOLE, OMEPRAZOLE reactions: Drug interaction, Drug-induced liver injury, Inflammation, Myocarditis, Off label use, Pyrexia, Tachycardia serious: 1 patientsex: 1 drugs: CYCLOPHOSPHAMIDE, DOXORUBICIN, ETOPOSIDE, PREDNISONE, RITUXIMAB, VINCRISTINE reactions: Locked-in syndrome serious: 1 patientsex: 1 drugs: DACTINOMYCIN, METHYLPREDNISOLONE, PREDNISOLONE reactions: Hepatitis C serious: 1 patientsex: 2 drugs: RIVASTIGMINE reactions: Drug ineffective serious: 1 patientsex: 2 drugs: SIROLIMUS reactions: Alkaline phosphatase increased, Gastroenteritis, Pyrexia, Thrombocytopenia serious: 1 patientsex: 1 drugs: ASPIRIN, HYDRALAZINE HYDROCHLORIDE, METOPROLOL, LISINOPRIL, SIMVASTATIN reactions: Acute kidney injury, Anti-neutrophil cytoplasmic antibody positive vasculitis, Glomerulonephritis rapidly progressive, Pulmonary haemorrhage serious: 1 patientsex: 1 drugs: DEHYDROEPINE PIPERACILLIN, HYDROCORTISONE, TESTOSTERONE reactions: Cytomegalovirus chorioretinitis, Drug abuse serious: 2 patientsex: 2 drugs: DIPPHENHYDRAMINE, DIPHENHYDRAMINE, MECLIZINE, METOCLOPRAMIDE, ONDANSETRON, PROCHLORPERAZINE reactions: Drug ineffective, Maternal exposure during pregnancy serious: 1 patientsex: 2 drugs: AMOXICILLIN reactions: Endocarditis, Pneumonia streptococcal serious: 1 patientsex: 1 drugs: CLOZAPINE, OLANZAPINE, RISPERIDONE, VALPROIC ACID, VENLAFAXINE HYDROCHLORIDE reactions: Delirium, Drug ineffective, Neuroleptic malignant syndrome serious: 1 patientsex: 1 drugs: PACLITAXEL, RAMUCIRUMAB reactions: Vascular pseudoaneurysm serious: 1 patientsex: 2 drugs: LEVETIRACETAM, VALPROIC ACID reactions: Bradycardia, Seizure, Syncope serious: 1 patientsex: 2 drugs: LACOSAMIDE, LEVETIRACETAM, LORAZEPAM, MIDAZOLAM HYDROCHLORIDE, PENTOBARBITAL, PHENOBARBITAL, PHENYTOIN, TOPIRAMATE reactions: Drug ineffective serious: 1 patientsex: 1 drugs: AZATHIOPRINE, ENOXAPARIN SODIUM, GLICLAZIDE, IBUPROFEN, METFORMIN HYDROCHLORIDE, PREDNISONE reactions: Diverticular perforation serious: 1 patientsex: 1 drugs: BISOPROLOL, INSULIN NOS, MESALAMINE, RIVAROXABAN reactions: Meningoencephalitis listeria serious: 1 patientsex: 1 drugs: ALLOPURINOL, ASPIRIN, IPRATROPIUM BROMIDEALBUTEROL SULFATE, PREDNISONE reactions: Colitis ischaemic, Lower gastrointestinal haemorrhage, Neuropathy peripheral, Off label use, Rash vasculitis serious: 1 patientsex: 1 drugs: AZD9291, GEFITINIB, ZOLEDRONIC ACID reactions: Drug effective for unapproved indication, Off label use serious: 1 patientsex: 1 drugs: ADALIMUMAB, INFLIXIMAB, METHOTREXATE, USTEKINUMAB reactions: Drug ineffective, Drug level below therapeutic, Drug level increased, Drug resistance, Drug level below therapeutic, Product use in unapproved indication serious: 1 patientsex: 2 drugs: PREGABALIN reactions: Anxiety, Depression, Drug withdrawal syndrome, Fear, Insomnia, Palpitations, Tremor serious: 1 patientsex: 2 drugs: FENTANYL, ISOFLURANE, THIOPENTAL, ROCURONIUM BROMIDE reactions: Exposure during pregnancy, Pulmonary embolism serious: 1 patientsex: 2 drugs: CYCLOSERINE, ETHIONAMIDE, LEVOFLOXACIN, KETAMYCIN, OLANZAPINE, PYRIDOXINE, TRIHEXYPHENIDYL reactions: Akathisia, Dysphagia, Extrapyramidal disorder, Neuroleptic malignant syndrome, Parkinsonism, Tremor serious: 1 patientsex: 2 drugs: AMITRIPTILINE, ESCITALOPRAM OXALATE, CLONAZEPAM, DESVENLAFAXINE, ETIZOLAM, OLANZAPINE, PAROXETINE, RISPERIDONE, SERTRALINE HYDROCHLORIDE reactions: Drug ineffective, Nausea, Treatment failure serious: 1 patientsex: 1 drugs: CISPLATIN, CYCLOPHOSPHAMIDE, CYTARABINE, DOXORUBICIN, ETOPOSIDE, METHYLPREDNISOLONE, PREDNISOLONE, RITUXIMAB, VINCRISTINE reactions: Drug ineffective serious: 1 patientsex: 1 drugs: DIPHENHYDRAMINE, EPINEPHRINE, METHYLPREDNISOLONE reactions: Myocardial infarction serious: 1 patientsex: 2 drugs: ADALIMUMAB reactions: Lupus-like syndrome serious: 1 patientsex: 1 drugs: ASPARAGINASE, GEMCITABINEGEMCITABINE HYDROCHLORIDE, OXALIPLATIN reactions: Mycobacterium fortuitum infection, Pneumonia, Septic shock serious: 1 patientsex: 2 drugs: BEVACIZUMAB, PACLITAXEL reactions: Anaemia, Constipation, Diarrhoea, Hypertension, Nausea, Neuropathy peripheral, Vomiting serious: 1 patientsex: 2 drugs: ACYCLOVIR, ASPIRIN, ATORVASTATIN, CALCIUM CARBONATE, CHOLECALCIFEROL, DEXAMETHASONE, LENALIDOMIDE, PANTOPRAZOLE, VENLAFAXINE HYDROCHLORIDE reactions: Cardiac failure, Dyspnoea, Palpitations serious: 1 patientsex: 2 drugs: TRASTUZUMAB reactions: Disease progression serious: 1 patientsex: 1 drugs: METHYLPREDNISOLONE, MYCOPHENOLIC ACID, TACROLIMUS reactions: Anaemia normochromic, Duodenopathy, Weight decreased serious: 1 patientsex: 2 drugs: FAMOTIDINE reactions: Bulbar palsy serious: 1 patientsex: 1 drugs: ACYCLOVIR, CEFTRIAXONE, DEXAMETHASONE, METRONIDAZOLE, VANCOMYCIN reactions: Bradycardia, Cerebral mucormycosis, Condition aggravated, Mental status changes serious: 1 patientsex: 1 drugs: SPIRONOLACTONE reactions: Burkitts lymphoma serious: 1 patientsex: 2 drugs: CLOZAPINE, HALOPERIDOL reactions: Treatment failure serious: 1 patientsex: 1 drugs: BEZLOTOXUMAB, FIDAXOMICIN, VANCOMYCIN reactions: Clostridium difficile infection serious: 1 patientsex: 1 drugs: DENOSUMAB reactions: Osteonecrosis of jaw serious: 1 patientsex: 1 drugs: FUROSEMIDE, LOSARTAN, OXYCODONE reactions: Atypical pneumonia, Drug reaction with eosinophilia and systemic symptoms serious: 1 patientsex: 1 drugs: BUSULFAN, CYCLOPHOSPHAMIDE, CYTARABINE, DEXAMETHASONE, DOXORUBICIN, FLUDARABINE PHOSPHATE, THIOTEPA, VINCRISTINE reactions: Graft versus host disease, Product use in unapproved indication serious: 1 patientsex: 2 drugs: HEPARIN SODIUM, WARFARIN reactions: Subcutaneous haemorrhage serious: 1 patientsex: 1 drugs: MYCOPHENOLATE MOFETIL, PREDNISONE, TACROLIMUS reactions: BK virus infection, Collecting duct carcinoma serious: 1 patientsex: 2 drugs: CYCLOPHOSPHAMIDE, CYCLOSPORINE, FLUDARABINE PHOSPHATE, MEROPENEM, THYMOCYTE IMMUNE GLOBULIN, VANCOMYCIN reactions: Hypertension, Pseudomonas infection, Skin oedema serious: 1 patientsex: 1 drugs: AMIKACIN, AZITHROMYCIN ANHYDROUS, MEROPENEM, LINEZOLID, TIGECYCLINE reactions: Clostridium difficile colitis, Nausea serious: 1 patientsex: 1 drugs: HYDROCORTISONE, FLUDROCORTISONE, TOCILIZUMAB reactions: Adrenal insufficiency, Drug ineffective, Thrombocytopenia serious: 1 patientsex: 2 drugs: CYCLOSPORINE, PREDNISOLONE, TACROLIMUS reactions: Aplasia pure red cell, Myasthenia gravis, Thymoma serious: 1 patientsex: 1 drugs: ESCITALOPRAM OXALATE, GLICLAZIDE, IRBESARTANHYDROCHLOROTHIAZIDE, LORAZEPAM, METFORMIN HYDROCHLORIDE, NIFEDIPINE, OMEPRAZOLE, SIMVASTATIN, RILUZOLE reactions: Inappropriate antidiuretic hormone secretion serious: 1 patientsex: 1 drugs: CARVEDILOL, DAPTOMYCIN, FUROSEMIDE, ERTAPENEM SODIUM, LISINOPRIL, SPIRONOLACTONE reactions: Drug ineffective serious: 1 patientsex: 2 drugs: NITROFURANTOIN reactions: Respiratory arrest serious: 1 patientsex: 2 drugs: CYCLOPHOSPHAMIDE, DOXORUBICIN, ETOPOSIDE, IRINOTECAN, LEUCOVORIN, OXALIPLATIN, PYRAZINAMIDE, VINCRISTINE reactions: Disease progression serious: 1 patientsex: 2 drugs: BUPIVACAINE, EPINEPHRINE, HYALURONIDASE, LIDOCAINE reactions: Brown syndrome serious: 1 patientsex: 2 drugs: CLOPIDOGREL BISULFATE reactions: Dermatitis bullous, Endothelial function test abnormal, Skin ulcer serious: 1 patientsex: 1 drugs: INFLIXIMAB, METHOTREXATE reactions: Diffuse large B-cell lymphoma, Non-Hodgkins lymphoma serious: 1 patientsex: 1 drugs: AZACITIDINE, BUSULFAN, CLOFARABINE, DAUNORUBICIN, ETOPOSIDE, MERCAPTOPURINE, PREDNISONE, RITUXIMAB, THIOGUAINE reactions: Acute myeloid leukaemia, Bone marrow failure, Drug ineffective, EBV viraemia, Splenomegaly serious: 1 patientsex: 1 drugs: LAMOTRIGINE, LEVETIRACETAM, OXCARBAZEPINE, TOPIRAMATE, VALPROIC ACID reactions: Cognitive disorder, Drug ineffective, Tic serious: 1 patientsex: 2 drugs: CEFEPIME HYDROCHLORIDE reactions: Acute kidney injury, Seizure serious: 1 patientsex: 1 drugs: PAZOPANIB reactions: Cardiac tamponade, Hypothyroidism serious: 1 patientsex: 1 drugs: INFLIXIMAB, METHOTREXATE, PREDNISOLONE, TACROLIMUS reactions: Mycobacterium marinum infection serious: 1 patientsex: 2 drugs: DICLOFENAC, CELECOXIB reactions: Gastric perforation serious: 1 patientsex: 2 drugs: ACYCLOVIR reactions: Cerebral haemorrhage serious: 1 patientsex: 1 drugs: BORTEZOMIB, DEXAMETHASONE, LENALIDOMIDE reactions: Herpes simplex oesophagitis serious: 1 patientsex: 1 drugs: EVEROLIMUS, PAZOPANIB, SUNITINIB MALATE reactions: Drug ineffective, Off label use serious: 1 patientsex: 2 drugs: EPIRUBICIN, IFOSFAMIDE reactions: Toxic encephalopathy serious: 1 patientsex: 1 drugs: DOXORUBICIN HYDROCHLORIDE reactions: Hepatic encephalopathy serious: 1 patientsex: 2 drugs: CARBOPLATIN, DOCETAXEL, PERTUZUMAB, TRASTUZUMAB reactions: Off label use serious: 1 patientsex: 2 drugs: CYTARABINE, ETOPOSIDE, PACLITAXEL, TEMOZOLOMIDE reactions: Status epilepticus serious: 1 patientsex: 2 drugs: CYCLOPHOSPHAMIDE, CYTARABINE, DEXAMETHASONE, DOXORUBICIN, ETOPOSIDE, IFOSFAMIDE, METHOTREXATE, PREDNISONE, VINCRISTINE reactions: Clostridium difficile infection, Hydrothorax, Pneumonia serious: 1 patientsex: 1 drugs: AMLODIPINE BESYLATE, ASPIRIN, FONDAPARINUX, HEPARIN SODIUM, OMEPRAZOLE, RAMIPRIL, SIMVASTATIN reactions: Deep vein thrombosis serious: 1 patientsex: 1 drugs: ASPIRIN, CIPROFLOXACIN, CIPROFLOXACIN HYDROCHLORIDE, CIPROFLOXACIN HYDROCHLORIDE, CIPROFLOXACIN HYDROCHLORIDE, CIPROFLOXACIN HYDROCHLORIDE, CIPROFLOXACIN HYDROCHLORIDE, CIPROFLOXACIN HYDROCHLORIDE, CIPROFLOXACIN HYDROCHLORIDE, CIPROFLOXACIN HYDROCHLORIDE, CIPROFLOXACIN HYDROCHLORIDE, CIPROFLOXACIN HYDROCHLORIDE, CIPROFLOXACIN HYDROCHLORIDE, CIPROFLOXACIN HYDROCHLORIDE, CIPROFLOXACIN HYDROCHLORIDE, CIPROFLOXACIN HYDROCHLORIDE, CIPROFLOXACIN serious: 1 patientsex: 2 drugs: METHYLPREDNISOLONE reactions: Drug ineffective serious: 1 patientsex: 2 drugs: RANITIDINE reactions: Foetal exposure during pregnancy, Premature baby serious: 1 patientsex: 2 drugs: ASPIRIN reactions: Arterial embolism serious: 1 patientsex: 1 drugs: CLONAZEPAM, METHAMPHETAMINE, PREGABALIN reactions: Coagulopathy, Drug abuse, Hepatic failure, Multiple organ dysfunction syndrome, Rhabdomyolysis, Toxicity to various agents serious: 1 patientsex: 1 drugs: ALEMTUZUMAB, EVEROLIMUS, PREDNISOLONE, TACROLIMUS reactions: Cytomegalovirus infection, Off label use, Product use in unapproved indication serious: 1 patientsex: 1 drugs: AMPICILLIN SODIUMSULBACTAM SODIUM, CIPROFLOXACIN, CEFTRIAXONE, GENTAMICIN, VANCOMYCIN reactions: Drug ineffective serious: 1 patientsex: 1 drugs: ABIRATERONE, DOCETAXEL, ETOPOSIDE, FLUOROURACIL, IPILIMUMAB, NIVOLUMAB, TOPOTECAN HYDROCHLORIDE reactions: Drug ineffective, Off label use serious: 1 patientsex: 1 drugs: ATRORENT, BECLOMETHASONE, METHYLPREDNISOLONE, PANTOPRAZOLE SODIUM reactions: Aspergillus infection, Cardiac arrest, Drug ineffective, Strongyloidiasis serious: 1 patientsex: 2 drugs: CARBOPLATIN, ETOPOSIDE reactions: Febrile neutropenia serious: 1 patientsex: 1 drugs: ACYCLOVIR, IBUPROFEN reactions: Acute generalised exanthematous pustulosis serious: 1 patientsex: 2 drugs: ANASTRAZOLE, TOBRAMYCIN reactions: Myasthenia gravis serious: 1 patientsex: 1 drugs: CHOLECALCIFEROL, LEVOTHYROXINE, OXYGEN, PREDNISOLONE ACETATE, SODIUM CHLORIDE reactions: Drug ineffective serious: 1 patientsex: 1 drugs: MYCOPHENOLIC ACID, TACROLIMUS reactions: Histoplasmosis, Hepatitis granulomatous serious: 1 patientsex: 2 drugs: CYCLOPHOSPHAMIDE, DOXORUBICIN HYDROCHLORIDE, PREDNISOLONE, VINCRISTINE reactions: Drug ineffective serious: 1 patientsex: 2 drugs: DACLIZUMAB, FINGOLIMOD HYDROCHLORIDE reactions: Neuromyelitis optica spectrum disorder serious: 1 patientsex: 2 drugs: METRONIDAZOLE, PIPERACILLIN SODIUMTAZOBACTAM SODIUM, VANCOMYCIN reactions: Drug ineffective serious: 1 patientsex: 1 drugs: LEVOFLOXACIN reactions: Anaphylactic reaction, Hypotension, Tachycardia serious: 1 patientsex: 1 drugs: CISPLATIN, VINORELBINEVINORELBINE TARTRATE reactions: Malignant neoplasm progression, Metastases to lung, Metastases to bone, Metastases to lymph nodes, Metastases to gastrointestinal tract, Metastases to skin, Metastases to gastrointestinal tract, Metastases to skin, Metastases to skin, Metastases to skin, Metastases to skin, Metastases to skin, Metastases to skin, Metastases to skin, Metastases to skin, Metastases to skin, Metastases to skin, Metastases to skin, Metastases to skin, Metastases to skin, Metastases to skin, Metastases to skin, Metastases to skin, Metastases to skin, Metastases to skin, Metastases to skin, Metastases to skin, Metastases to skin, Metastases to skin, Metastases to skin, Metastases to skin, Metastases to skin, Metastases to skin, Metastases to skin, Metastases to skin, Metastases to serious: 1 patientsex: 1 drugs: ASPIRIN, TICAGRELOR reactions: Von Willebrands disease acquired, Thrombocytosis serious: 1 patientsex: 1 drugs: LEUPROLIDE ACETATE reactions: Hot flush, Off label use, Prostatic specific antigen increased serious: 1 patientsex: 1 drugs: MEROPENEM, PIPERACILLIN SODIUMTAZOBACTAM SODIUM, VANCOMYCIN reactions: Drug ineffective serious: 1 patientsex: 2 drugs: CARBOPLATIN, CISPLATIN, DOXORUBICIN, GEMCITABINEGEMCITABINE HYDROCHLORIDE, PACLITAXEL, NEDAPLATIN reactions: Drug ineffective, Drug resistance, Intestinal obstruction, Metastases to pelvis, Metastases to lung serious: 1 patientsex: 1 drugs: METHOTREXATE reactions: Aspartate aminotransferase increased, Hypokalaemia serious: 1 patientsex: 2 drugs: CLONAZEPAM, LEVETIRACETAM, VALPROIC ACID reactions: Drug ineffective serious: 1 patientsex: 2 drugs: CYCLOPHOSPHAMIDE, DOXORUBICIN, PACLITAXEL, TRASTUZUMAB reactions: Cardiac failure, Cardiotoxicity serious: 1 patientsex: 1 drugs: AZATHIOPRINE, CYCLOSPORINE, PREDNISOLONE reactions: Atypical Burkitts lymphoma, Anaemia, Diffuse large B-cell lymphoma, Gastric mucosal ulcer, Lymphadenopathy, Post transplant lymphoproliferative disorder, Renal impairment serious: 1 patientsex: 2 drugs: AZATHIOPRINE, CYCLOSPORINE, PREDNISOLONE reactions: Blood pressure increased, Foetal exposure during pregnancy, Proteinuria, Respiratory distress, Tachypnoea serious: 1 patientsex: 1 drugs: CLONAZEPAM, BIPERIDEN, LITHIUM, RISPERIDONE reactions: Status epilepticus, Toxicity to various agents serious: 1 patientsex: 1 drugs: PHENYTOIN reactions: Drug ineffective, Drug interaction serious: 1 patientsex: 2 drugs: ENTECAVIR, DOXORUBICIN HYDROCHLORIDE, GELATIN, HYDROCORTISONE, METRONIDAZOLE, PIPERACILLIN SODIUMTAZOBACTAM SODIUM, VANCOMYCIN reactions: Clostridium infection, Hepatic abscess serious: 1 patientsex: 2 drugs: BLEOMYCIN SULFATE, DACARBAZINE, DOXORUBICIN, VINBLASTINE reactions: Drug intolerance, Drug resistance serious: 1 patientsex: 1 drugs: DASATINIB reactions: Skin depigmentation serious: 1 patientsex: 2 drugs: ALBUTEROL, ALPRAZOLAM, CALCITRIOL, BUMETANIDE, CALCIUM, FERROUS SULFATE, FLUTICASONE, OMEPRAZOLE, POTASSIUM BICARBONATE, TIZANIDINE HYDROCHLORIDE, VALSARTAN reactions: Acute kidney injury, Hypocalcaemia, Hyponatraemia, Leukocytosis, Metabolic acidosis, Rhabdomyolysis, Toxicity to various agents serious: 1 patientsex: 1 drugs: AZATHIOPRINE, MYCOPHENOLIC ACID, PREDNISONE, TACROLIMUS reactions: Hyponatraemia, Phaeohyphomycosis serious: 1 patientsex: 2 drugs: GEMCITABINEGEMCITABINE HYDROCHLORIDE, SUNITINIB MALATE reactions: Inappropriate antidiuretic hormone secretion, Inappropriate antidiuretic hormone secretion, Inappropriate antidiuretic hormone secretion, Inappropriate antidiuretic hormone secretion, Inappropriate antidiuretic hormone secretion, Inappropriate antidiuretic hormone secretion, Inappropriate antidiuretic hormone secretion, Inappropriate antidiuretic hormone secretion, Inappropriate antidiuretic hormone secretion, Inappropriate antidiuretic hormone secretion, Inappropriate antidiuretic hormone secretion, Inappropriate antidiuretic hormone secretion, Inappropriate antidiuretic hormone secretion, Inappropriate antidiuretic hormone secretion, Inappropriate antidiuretic hormone secretion, Inappropriate antidiuretic hormone secretion, Inappropriate antidiuretic serious: 1 patientsex: 1 drugs: NIVOLUMAB reactions: Cholangitis, Drug-induced liver injury, Hepatitis allergic serious: 1 patientsex: 1 drugs: BISOPROLOL, BENIDIPINE, IMIDAPRIL, NICORANDIL, WARFARIN reactions: Drug interaction, Haematuria, International normalised ratio increased serious: 1 patientsex: 1 drugs: CLOFAZIMINE, DAPSONE, RIFAMPIN reactions: Abdominal pain, Crystal deposit intestine, Gastrointestinal disorder serious: 1 patientsex: 1 drugs: ASPIRIN, CARVEDILOL, EMPAGLIFLOZIN, HYDROCHLOROTHIAZIDE, INSULIN NOS, IPRATROPIUM BROMIDE, METFORMIN HYDROCHLORIDE, PANTOPRAZOLE SODIUM, ROSUVASTATIN, VALSARTAN reactions: Dehydration, Hypernatraemia, Hyperglycaemia, Hyponatraemia, Renal failure, Tachycardia serious: 1 patientsex: 2 drugs: IPILIMUMAB, NIVOLUMAB reactions: Hyperglycaemia, Type 1 diabetes mellitus serious: 1 patientsex: 2 drugs: ANAKINRA, HYDROXYCHLOROQUINE, METFORMIN HYDROCHLORIDE reactions: Long QT syndrome serious: 1 patientsex: 2 drugs: CINACALCET reactions: Pancreatitis serious: 1 patientsex: 1 drugs: BEVACIZUMAB, TRIAMCINOLONE ACETONIDE reactions: Disease progression, Off label use, Visual acuity reduced serious: 1 patientsex: 1 drugs: EVEROLIMUS, METHOTREXATE, MYCOPHENOLIC ACID, TOCILIZUMAB reactions: Chronic graft versus host disease, Sepsis serious: 1 patientsex: 1 drugs: PEMBROLIZUMAB reactions: Hepatitis, Myasthenia gravis, Myositis serious: 1 patientsex: 1 drugs: AMOXICILLINCLAVULANIC ACID, CLINDAMYCIN, LEVOFLOXACIN, PREDNISONE reactions: Drug ineffective serious: 1 patientsex: 1 drugs: ETHAMBUTOL HYDROCHLORIDE, ISONIAZID, PYRAZINAMIDE, RIFAMPIN reactions: Drug intolerance, Jaundice, Hepatotoxicity serious: 1 patientsex: 1 drugs: CYCLOPHOSPHAMIDE, DOXORUBICIN HYDROCHLORIDE, PREDNISOLONE, VINCRISTINE reactions: Cholangitis, Septic shock serious: 1 patientsex: 1 drugs: NITROUS OXIDE reactions: Vitamin B12 deficiency, Drug abuse serious: 1 patientsex: 1 drugs: AZITHROMYCIN ANHYDROUS, CASPOFUNGIN, IMIPENEM, PIPERACILLIN SODIUMTAZOBACTAM SODIUM, TOBRAMYCIN, VANCOMYCIN reactions: Drug ineffective serious: 1 patientsex: 1 drugs: LITHIUM, MOCLOBEMIDE, PRIMIDONE, SERTRALINE HYDROCHLORIDE, VALPROIC ACID, VENLAFAXINE HYDROCHLORIDE reactions: Cognitive disorder, Cognitive disorder recurrent serious: 1 patientsex: 1 drugs: CYCLOPHOSPHAMIDE, DOXORUBICIN, PREDNISOLONE, VINCRISTINE reactions: Malignant neoplasm progression, Metastases to central nervous system, Metastases to liver, Metastases to lung, Metastases to spine, Metastases to gastrointestinal tract, Metastases to skin, Metastases to pleura, Metastases to gastrointestinal tract, Metastases to skin, Metastases to liver, Metastases to gastrointestinal tract, Metastases to skin, Metastases to gastrointestinal tract, Metastases to skin, Metastases to gastrointestinal tract, Metastases to skin, Metastases to skin, Metastases to gastrointestinal tract, Metastases to skin, Metastases to skin, Metastases to skin, Metastases to skin, Metastases to skin, Metastases to skin, Metastases to skin, Metastases to skin, Metastases to skin, Metastases to skin, Metastases to skin, Metastases to skin, Metastases to skin, Metastases to skin, serious: 1 patientsex: 2 drugs: GOLIMUMAB, HYDROXYCHLOROQUINE, LEFLUNOMIDE, PREDNISONE reactions: Pericardial effusion, Pericardial mass serious: 1 patientsex: 2 drugs: CALCITRIOL, CALCIUM CARBONATE, MAGNESIUM reactions: Drug ineffective, Hypocalcaemia, Hypomagnesaemia, Off label use, Product use in unapproved indication serious: 1 patientsex: 1 drugs: LACOSAMIDE, LEVETIRACETAM, VALPROIC ACID reactions: Myoclonus, Off label use, Seizure serious: 1 patientsex: 2 drugs: ASPIRIN, CILOSTAZOL, HEPARIN SODIUM, WARFARIN reactions: Maternal exposure during pregnancy serious: 1 patientsex: 2 drugs: TOPIRAMATE reactions: Angle closure glaucoma, Cataract subcapsular serious: 1 patientsex: 1 drugs: CISPLATIN, IRINOTECAN reactions: Disseminated intravascular coagulation, Febrile neutropenia, Pantoea infection, Sepsis serious: 1 patientsex: 2 drugs: HALOPERIDOL, FAMOTIDINE, OLANZAPINE, SERTRALINE HYDROCHLORIDE reactions: Drug-induced liver injury, Exposure during pregnancy serious: 1 patientsex: 1 drugs: CEFTRIAXONE, DEXAMETHASONE, PIPERACILLIN SODIUMTAZOBACTAM SODIUM, TOBRAMYCIN reactions: Acute kidney injury, Renal failure serious: 1 patientsex: 2 drugs: CEFTRIAXONE, CIPROFLOXACIN, METRONIDAZOLE reactions: Drug ineffective serious: 1 patientsex: 1 drugs: ADALIMUMAB, CAPTOPRIL, CITALOPRAM HYDROBROMIDE, ETANERCEPT, HYDROXYCHLOROQUINE, METHOTREXATE, PREDNISOLONE reactions: Ankylosing spondylitis, Diffuse systemic sclerosis, Scleroderma renal crisis serious: 1 patientsex: 2 drugs: GEMCITABINEGEMCITABINE HYDROCHLORIDE, ZOLEDRONIC ACID reactions: Cardiac failure, Left ventricular dysfunction serious: 1 patientsex: 2 drugs: METHYLPREDNISOLONE reactions: Drug ineffective serious: 1 patientsex: 2 drugs: TRANILAST reactions: Cardiac arrest, Drug effective for unapproved indication, Off label use, Ventricular extrasystoles serious: 1 patientsex: 1 drugs: AZITHROMYCIN ANHYDROUS, CEFTRIAXONE, IBUPROFEN, METHYLPREDNISOLONE, PIPERACILLIN SODIUMTAZOBACTAM SODIUM, PREDNISONE, VANCOMYCIN reactions: Condition aggravated, Leukocytosis, Pneumonia, Pleural effusion, Sinus tachycardia serious: 1 patientsex: 1 drugs: BLEOMYCIN SULFATE, CISPLATIN, ETOPOSIDE, PEGFILGRASTIM reactions: Drug ineffective, Febrile neutropenia serious: 1 patientsex: 1 drugs: PREDNISONE reactions: Diverticulitis, Peritonitis, Respiratory failure serious: 1 patientsex: 2 drugs: BENZTROPINE, RISPERIDONE reactions: Dystonia, Extrapyramidal disorder, Respiratory acidosis serious: 1 patientsex: 2 drugs: CAPECITABINE, CISPLATIN, FLUOROURACIL reactions: Hepatic infarction, Metabolic encephalopathy serious: 1 patientsex: 2 drugs: DIAZOXIDE, GLUCAGON, OCTREOTIDE, SIROLIMUS reactions: Diarrhoea, Drug level below therapeutic, Hepatitis serious: 1 patientsex: 2 drugs: CETUXIMAB, FLUOROURACIL, IRINOTECAN, LEUCOVORIN reactions: Steatohepatitis serious: 1 patientsex: 1 drugs: ISONIAZID, RIFAMPIN reactions: Tuberculosis serious: 1 patientsex: 2 drugs: BORTEZOMIB, CYCLOPHOSPHAMIDE, DEXAMETHASONE, DOXORUBICIN, MELPHALAN, POMALIDOMIDE, VINCRISTINE reactions: Anaemia, Drug ineffective, Hepatitis B, Neutropenia, Pneumogenic septic shock, Thrombocytopenia serious: 1 patientsex: 1 drugs: ARSENIC TRIOXIDE, TRETINOIN reactions: Idiopathic intracranial hypertension serious: 1 patientsex: 1 drugs: PROPRANOLOL HYDROCHLORIDE reactions: Coma, Hypoglycaemia, Hypothermia, Hypotension, Pallor, Somnolence serious: 1 patientsex: 1 drugs: SODIUM POLYSTYRENE SULFONATE, SEVELAMER HYDROCHLORIDE reactions: Diverticulum, Intestinal perforation serious: 1 patientsex: 2 drugs: ABATACEPT, METHOTREXATE, PREDNISOLONE, SULFASALAZINE, TACROLIMUS, TOFACITINIB CITRATE reactions: Seborrhoeic keratosis, Squamous cell carcinoma serious: 1 patientsex: 1 drugs: DEXTROSE, INSULIN NOS, SODIUM CHLORIDE reactions: Cerebral oedema serious: 1 patientsex: 2 drugs: AMPHOTERICIN B, FLUCYTOSINE, IMATINIB, PREDNISONE, VORICONAZOLE reactions: Condition aggravated, Drug ineffective, Hemiplegia, Meningitis cryptococcal, Pneumonitis, Respiratory failure serious: 1 patientsex: 1 drugs: ZINC reactions: Febrile neutropenia serious: 1 patientsex: 2 drugs: BASILIXIMAB, MYCOPHENOLATE MOFETIL, PREDNISOLONE, RITUXIMAB, TACROLIMUS reactions: Epstein-Barr virus infection, Leiomyosarcoma serious: 1 patientsex: 2 drugs: BROMOCRIPTINE, CABERGOLINE, ESTRADIOL, FOLIC ACID, GANIREX, LETROZOLE, MENOPUR, OXYCODONE, TYLENOL, VANCOMYCIN reactions: Maternal exposure during pregnancy, Normal newborn, Skin necrosis, Skin ulcer, Skin haemorrhage, Skin ulcer, Vascular herniation serious: 1 patientsex: 2 drugs: NATALIZUMAB reactions: Immune reconstitution inflammatory syndrome, Progressive multifocal leukoencephalopathy serious: 1 patientsex: 2 drugs: ASPIRIN, OXYGEN reactions: Retinal haemorrhage, Retinal vein occlusion serious: 1 patientsex: 2 drugs: EPINEPHRINE reactions: Accidental exposure to product, Device malfunction, Injection site injury, Injection site laceration, Injection site pain, Injection site injury, Injection site thigh, Injection site injury, Injection site pain, Injection site injury, Injection site pain, Injection site injury, Injection site pain, Injection site injury, Injection site pain, Injection site injury, Injection site pain, Injection site pain, Injection site pain, Injection site discomfort, Injection site pain, Injection site discomfort, Injection site pain, Injection site discomfort, Injection site pain, Injection site discomfort, Injection site pain, Injection site discomfort, Injection site pain, Injection site discomfort, Injection site pain, Injection site discomfort, Injection site pain, Injection site discomfort, Injection site pain, Injection site discomfort, Injection site pain, Injection site discomfort, Injection site pain, Injection site discomfort, Injection site pain, Injection site discomfort, Injection site pain, Injection site discomfort, Injection site pain, Injection site discomfort, Injection site pain, In serious: 1 patientsex: 1 drugs: LEUPROLIDE ACETATE reactions: Pituitary apoplexy serious: 1 patientsex: 2 drugs: HEPARIN SODIUM, MYCOPHENOLATE MOFETIL, TACROLIMUS, WARFARIN reactions: Renal infarct serious: 1 patientsex: 2 drugs: ASPIRIN, DOBUTAMINEDOBUTAMINE HYDROCHLORIDE, EPINEPHRINE, FONDAPARINUX, GENTAMICIN, ISOPROTERENOL, MEROPENEM, METHYLPREDNISOLONE, NOREPINEPHRINE, TICAGRELOR reactions: Acute kidney injury, Atrioventricular block complete, Bradycardia, Cardiogenic shock, Circulatory collapse, Drug ineffective, Hypoperfusion, Hypoperfusion, Lactic acidosis, Oliguria, Pericardial effusion, Pericardial effusion, Pericardial effusion, Pericardial effusion, Pericardial effusion, Pericardial effusion, Pericardial effusion, Pericardial effusion, Pericardial effusion, Upper gastrointestinal haemorrhage, Spinal cord injury, Spinal injury, Ventricular extrasystoles serious: 1 patientsex: 1 drugs: CYCLOPHOSPHAMIDE, DOXORUBICIN, PREDNISOLONE, VINCRISTINE reactions: Glomerulonephritis membranoproliferative, Nephrotic syndrome serious: 1 patientsex: 2 drugs: AMOXICILLINCLAVULANIC ACID, DEXMEDETOMIDINE, ENOXAPARIN, HYDROXYCHLOROQUINE, MIDAZOLAM HYDROCHLORIDE, PYRITHRAMIDE reactions: Thrombotic stroke serious: 1 patientsex: 2 drugs: AMLODIPINE BESYLATE, ASPIRIN, CILOSTAZOL, INSULIN NOS, ROSUVASTATIN CALCIUM, TELMISARTAN reactions: Reversible cerebral vasoconstriction syndrome, Reversible cerebral vasoconstriction syndrome, Pre-eclampsia serious: 1 patientsex: 1 drugs: AZATHIOPRINE, MEROPENEM, METHYLPREDNISOLONE, PREDNISOLONE reactions: Herpes simplex, Oesophagitis, Pharyngotonsillitis serious: 1 patientsex: 1 drugs: PREDNISONE reactions: Osteonecrosis serious: 1 patientsex: 2 drugs: ETHAMBUTOL HYDROCHLORIDE, ISONIAZIDPYRAZINAMIDE, METOPROLOL, MOXIFLOXACIN, PREDNISONE, PYRAZINAMIDE, RIFAMPIN reactions: Acute kidney injury, Hepatitis, Multiple organ dysfunction syndrome, Septic shock serious: 1 patientsex: 2 drugs: FLUOROURACIL, LEUCOVORIN reactions: Gastrointestinal haemorrhage serious: 1 patientsex: 1 drugs: CARBIDOPAENTACAPONE, DOXYCYCLINE, RASAGILINE, ROTIGOTINE reactions: Depressed mood, Parkinsons disease, Sleep disorder serious: 1 patientsex: 1 drugs: AZITHROMYCIN ANHYDROUS, COGENTIN, CLONAZEPAM, PREDNISONE, RISPERIDONE, VENLAFAXINE HYDROCHLORIDE, ZOLPIDEM TARTRATE reactions: Acute kidney injury, Confusional state, Hyperglycaemia, Memory impairment serious: 1 patientsex: 1 drugs: CYTARABINE, METHOTREXATE reactions: Hepatitis B reactivation serious: 1 patientsex: 1 drugs: AMLODIPINE BESYLATE, ENOXAPARIN, HYDROXYCHLOROQUINE, METFORMIN HYDROCHLORIDE, NIFEDIPINE reactions: Drug ineffective, Gangrene, Respiratory failure serious: 1 patientsex: 1 drugs: ALLOPURINOL, ASPIRIN, ATORVASTATIN, ACETAMINOPHEN, ATORVASTATIN CALCIUM, DICLOFENAC, MIRTAZAPINE, PERINDOPRIL, TIOTROPIUM BROMIDE reactions: Dementia with Lewy bodies, Fall, Ecchymosis, Fall rib, Fall, Fall, Fall, Fall, Fall, Fall, Fall, Fall, Fall, Fall, Fall, Fall, Fall, Fall, Fall, Fall, Fall, Fall, Fall, Fall, Fall, Fall, Fall, Fall, Fall, Fall, Fall, Fall, Fall, Fall, Fall, Fall, Fall, Fall, Fall, Fall, Fall, Fall, Fall, Fall, Fall, Fall, Fall, Fall, Fall, Fall, Fall, Fall, Fall, Fall, Fall, Fall, Fall, Fall, Fall, Fall, Fall, Fall, Fall, Fall, Fall, Fall, Fall, Fall, Fall, Fall, Fall, Fall, Fall, Fall, Fall, Fall, Fall, Fall, Fall, Fall, Fall, Fall, Fall, Fall, serious: 2 patientsex: 1 drugs: ARIPIPRAZOLE, GUANFACINE, RISPERIDONE reactions: Apnoea-hypopnoea index increased, Hypersomnia serious: 1 patientsex: 1 drugs: GADOLINIUM reactions: Nephrogenic systemic fibrosis serious: 1 patientsex: 1 drugs: CARBOPLATIN, ETOPOSIDE, HUMAN IMMUNOGLOBULIN G, LACOSAMIDE, LEVETIRACETAM, OLANZAPINE, VALPROIC ACID reactions: Febrile neutropenia, Septic shock serious: 1 patientsex: 2 drugs: ATORVASTATIN, DOCETAXEL reactions: Nail toxicity, Palmar-plantar erythrodysaesthesia syndrome serious: 1 patientsex: 1 drugs: AZATHIOPRINE, CALCIUM CARBONATE, FOLIC ACID, PREDNISONE, SIMVASTATIN, SPIRONOLACTONE, URSACOL reactions: Bacterial infection, Drug ineffective, Septic shock serious: 1 patientsex: 1 drugs: WARFARIN reactions: Gait disturbance, Gait disturbance serious: 1 patientsex: 2 drugs: CARBOPLATIN, PACLITAXEL reactions: Alopecia, Asthenia, Neutropenia, Thrombosis neck vein serious: 1 patientsex: 1 drugs: BRIVARICETAM reactions: Aggression, Cry, Dysarthria, Fall, Hypotonia, Social interaction disorder serious: 1 patientsex: 2 drugs: CEFTRIAXONE, DEXAMETHASONE, METRONIDAZOLE reactions: Drug ineffective serious: 1 patientsex: 1 drugs: BENZTROPINE, CLOZAPINE, LEVODOPA, METOCLOPRAMIDE, QUETIAPINE, TRIHEXYPHENIDYL reactions: Parkinsonism serious: 1 patientsex: 1 drugs: IMATINIB MESYLATE reactions: Acute myeloid leukaemia recurrent serious: 1 patientsex: 2 drugs: CYCLOPHOSPHAMIDE, DOXIFLORTIDE, PACLITAXEL, ONDANSETRON reactions: Abdominal wall necrosis, Abdominal pain, Asthenia, Cachexia, Diarrhoea, Hypotension, Hypotension, Multiple organ dysfunction syndrome, Neutropenic colitis, Small intestinal perforation, Shock, Tachypnoea serious: 1 patientsex: 1 drugs: AMOXICILLINCLAVULANIC ACID, AMPICILLIN, CEPHALEXIN, CIPROFLOXACIN, CIPROFLOXACIN HYDROCHLORIDE, CIPROFLOXACIN HYDROCHLORIDE, CIPROFLOXACIN HYDROCHLORIDE, CIPROFLOXACIN HYDROCHLORIDE, CIPROFLOXACIN HYDROCHLORIDE, CIPROFLOXACIN HYDROCHLORIDE, CIPROFLOXACIN HYDROCHLORIDE, CIPROFLOXACIN HYDROCHLORIDE, CIPROFLOXACIN HYDROCHLORIDE, CIPROFLOXACIN HYDROCHLORIDE, CIPROFLOXACIN HYDROCHLORIDE, CIPROFLOXACIN HYDROCHLORIDE, CIPROFLOXACIN HYDROCHLORIDE, CI serious: 1 patientsex: 2 drugs: FOLIC ACID, LAMOTRIGINE, LEVETIRACETAM reactions: Hypoglycaemia, Hyposthenia, Seizure serious: 1 patientsex: 1 drugs: CISPLATIN, GEMCITABINEGEMCITABINE HYDROCHLORIDE reactions: Disease progression serious: 1 patientsex: 1 drugs: PREDNISONE reactions: Paracoccidioidomycosis serious: 1 patientsex: 2 drugs: HEPARIN SODIUM reactions: Hyperhaemolysis syndrome serious: 1 patientsex: 1 drugs: CEFUROXIME, CLINDAMYCIN, DOXYCYCLINE, METRONIDAZOLE, MEROPENEM, VANCOMYCIN reactions: Drug hypersensitivity, Lemierres syndrome, Pulmonary embolism, Respiratory failure serious: 1 patientsex: 1 drugs: AMPHOTERICIN B, POSACONAZOLE reactions: Anaemia, Neutropenia serious: 1 patientsex: 1 drugs: IBUPROFEN reactions: Compartment syndrome, Suicide attempt serious: 1 patientsex: 1 drugs: ASPIRIN, ATORVASTATIN, DOCUSATE, LOSARTAN, OMEPRAZOLE, ZOLPIDEM TARTRATE reactions: Abdominal pain, Abdominal pain upper, Abdominal pain lower, Abdominal pain upper, Abdominal pain lower, Abdominal pain upper, Abdominal pain lower, Abdominal pain upper, Abdominal pain lower, Abdominal pain upper, Abdominal pain lower, Abdominal pain upper, Abdominal pain lower, Abdominal pain upper, Abdominal pain lower, Abdominal pain upper, Abdominal pain lower, Abdominal pain upper, Abdominal pain lower, Abdominal pain upper, Abdominal pain lower, Abdominal pain upper, Abdominal pain lower, Abdominal pain upper, Abdominal pain lower, Abdominal pain upper, Abdominal pain lower, Abdominal pain upper, Abdominal pain lower, Abdominal pain upper, Abdominal pain lower, Abdominal pain upper, Abdominal pain lower, Abdominal pain upper, Abdominal serious: 1 patientsex: 2 drugs: CEPHALEXIN, CEFTRIAXONE reactions: Diarrhoea, Pregnancy test false positive serious: 1 patientsex: 1 drugs: ARIPIPRAZOLE, ARIPIPRAZOLE LAURATE reactions: Drug ineffective, Drug interaction, Treatment failure serious: 1 patientsex: 1 drugs: BUPRENORPHINE reactions: Drug resistance, Intentional product use issue, Intentional product use issue, Mental disorder, Post traumatic stress disorder serious: 1 patientsex: 1 drugs: CARBOPLATIN, PEMETREXED reactions: Drug ineffective serious: 1 patientsex: 1 drugs: CISPLATIN, FLUOROURACIL reactions: Pneumatosis intestinalis serious: 1 patientsex: 2 drugs: CIPROFLOXACIN reactions: Optic pseudotumour serious: 1 patientsex: 2 drugs: EPOPOSTENOL, REMDESIVIR reactions: Drug ineffective serious: 1 patientsex: 2 drugs: AMOXICILLIN, CIPROFLOXACIN, SULFAMETHOXAZOLETRIMETHOPRIM reactions: Drug ineffective serious: 1 patientsex: 1 drugs: MOXIFLOXACIN HYDROCHLORIDE, TIMOLOL reactions: Bacterial infection, Conjunctivitis serious: 1 patientsex: 2 drugs: BENZTROPINE, ESCITALOPRAM OXALATE, HALOPERIDOL, LEVOTHYROXINE, LORAZEPAM, METOPROLOL TARTRATE, PANTOPRAZOLE SODIUM, LOSARTAN, POTASSIUM CHLORIDE, TEMAZEPAM, RISPERIDONE, TEMOZOLOMIDE, TEMAZEPAM HYDROCHLORIDE, LOSARTAN, TEMAZEPAM HYDROCHLORIDE, TEMOZOLOMIDE, LOSARTAN, TEMAZEPAM HYDROCHLORIDE, TEMOZOLOMIDE, LOSARTAN, TEMAZEPAM, RISPERIDONE, TEMAZEPAM HYDROCHLORIDE, RISPERIDONE, TEMAZEPAM HYDROCHLORIDE, RISPERIDONE, TEMAZEPAM HYDROCHLORIDE, RISPERIDONE, TEMAZEPAM HYDROCHLOR serious: 1 patientsex: 1 drugs: CEFTRIAXONE, HEPARIN SODIUM, IBUPROFEN, METRONIDAZOLE, MEROPENEM, MORPHINE, NAFCILLIN, RANITIDINE, VANCOMYCIN reactions: Hypokalaemia serious: 1 patientsex: 1 drugs: CYCLOPHOSPHAMIDE, DOXORUBICIN, PREDNISOLONE, VINCRISTINE reactions: Anaemia, Asthenia, Bone pain, Fatigue, Neutropenia, Off label use, Thrombocytopenia serious: 1 patientsex: 2 drugs: MEDROXYPROGESTERONE ACETATE reactions: Deep vein thrombosis serious: 1 patientsex: 1 drugs: BEVACIZUMAB, FLUOROURACIL, IRINOTECAN, LEUCOVORIN, OXALIPLATIN reactions: Atrial fibrillation serious: 1 patientsex: 1 drugs: LAMIVUDINE, PREDNISOLONE reactions: Myositis serious: 1 patientsex: 2 drugs: ACENOCOUMAROL, AMIODARONE, CAPTOPRIL, DIGOXIN, FUROSEMIDE, METOPROLOL, RAMIPRIL, SPIRONOLACTONE reactions: Hyperkalaemia serious: 1 patientsex: 1 drugs: AMLODIPINE BESYLATE, ASPIRIN, CARVEDILOL, METHOTREXATE, PEGLUTICASE reactions: Anaemia haemolytic serious: 1 patientsex: 1 drugs: OSELTAMIVIR, MOXIFLOXACIN, PIPERACILLIN SODIUMTAZOBACTAM SODIUM, VORICONAZOLE reactions: Confusional state, Hallucination, visual serious: 1 patientsex: 2 drugs: CAPECITABINE, OXALIPLATIN reactions: Acute respiratory distress syndrome, Acute kidney injury, Ascites, Ascites fibrinous, Ascites hyaline membranes, Ascites, Cardiotoxicity, Diarrhoea, Diarrhoea, Dystelectasis, Hepatic steatosis, Hepatic failure, Hepatic steatosis, Hepatic failure, Hepatic steatosis, Hepatic failure, Hepatic steatosis, Hepatic failure, Hepatic steatosis, Hepatic failure, Hepatic steatosis, Hepatic failure, Hepatic steatosis, Hepatic failure, Hepatic steatosis, Hepatic failure, Hepatic failure, Hepatic fibrosis, Hepatic failure, Hepatic steatosis, Hepatic failure, Hepatic failure, Hepatic fibrosis, serious: 1 patientsex: 2 drugs: CEFOTAXIME SODIUM reactions: Acute respiratory failure, Cerebral vasculitis, Generalised tonic-clonic seizure, Hemiplegia serious: 1 patientsex: 2 drugs: LEUPROLIDE ACETATE reactions: Multiple sclerosis serious: 1 patientsex: 1 drugs: PEMBROLIZUMAB reactions: Iridocyclitis, Ocular pain, Papillitis, Synechiae, Uveitis serious: 1 patientsex: 2 drugs: ACETAMINOPHEN, CLONAZEPAM, FENTANYL, KETOROLAC TROMETHAMINE, KETOROLAC TROMETHAMINE HYDROCHLORIDE, KETOROLAC TROMETHAMINE HYDROCHLORIDE, LORAZEPAM, KETOROLAC TROMETHAMINE, OXYCODONE, QUETIAPINE, SEVOFLURANE reactions: Hypoxia serious: 1 patientsex: 1 drugs: CLOBAZAM, CLONIDINE, FELBAMATE, LITHIUM, PERPHENAZINE, QUETIAPINE, TRAZODONE HYDROCHLORIDE reactions: Drug interaction, Hypersomnia, Off balance, Toxicity to various agents serious: 1 patientsex: 1 drugs: EFAVIRENZ, EMTRICITABINE, LISINOPRIL, TENOFOVIR reactions: Glomerulonephritis membranous serious: 1 patientsex: 1 drugs: EVEROLIMUS reactions: Diarrhoea, Fatigue, Interstitial lung disease, Nausea, Neutropenia, Vomiting serious: 1 patientsex: 2 drugs: SERTRALINE HYDROCHLORIDE reactions: Haemichorea serious: 1 patientsex: 1 drugs: CISPLATIN, ETOPOSIDE reactions: Anaemia, Haemoperitoneum, Hepatic artery ruptured serious: 1 patientsex: 2 drugs: METHOTREXATE reactions: Liver enzyme increased, Nausea serious: 1 patientsex: 2 drugs: CYCLOPHOSPHAMIDE, CYTARABINE, DEXAMETHASONE, DOXORUBICIN, METHOTREXATE, VINCRISTINE reactions: Alveolar haemorrhage, Haemoptysis, Neutropenia, Septic shock serious: 1 patientsex: 2 drugs: ETHIODIZED OIL, OFLOXACIN, PYRAZINAMIDE, RIFAMPIN, STREPTOMYCINSTREPTOMYCIN SULFATE, VORICONAZOLE reactions: Adrenal insufficiency, Cerebral aspergillosis, Drug ineffective, Pyrexia, Seizure serious: 1 patientsex: 1 drugs: AMPICILLIN SODIUMSULBACTAM SODIUM, FUROSEMIDE reactions: Drug ineffective serious: 1 patientsex: 2 drugs: BEVACIZUMAB, FLUOROURACIL, IRINOTECAN, LEUCOVORIN reactions: Intestinal obstruction, Mucosal inflammation serious: 1 patientsex: 2 drugs: CIPROFLOXACIN, ISONIAZID, METHOTREXATE, ITRACONAZOLE reactions: Fungaemia, Neutropenia, Trichosporon infection serious: 1 patientsex: 2 drugs: DENOSUMAB, PANTOPRAZOLE SODIUM, SIMVASTATIN reactions: Gastroduodenitis, Gastrointestinal haemorrhage serious: 1 patientsex: 2 drugs: AFATINIB reactions: Drug resistance serious: 1 patientsex: 1 drugs: METHYLPREDNISOLONE, MYCOPHENOLATE MOFETIL, PREDNISONE reactions: Off label use serious: 1 patientsex: 1 drugs: CEFEPIME HYDROCHLORIDE, LEVOFLOXACIN, ZOLPIDEM TARTRATE reactions: Oedema peripheral, Oedema peripheral serious: 1 patientsex: 1 drugs: CARBAMAZEPINE, PROPARACAINE HYDROCHLORIDE reactions: Drug abuse, Drug dependence, Iridocyclitis, Ocular hypopyon, Ophthalmic steroid disorder, Visual acuity reduced serious: 1 patientsex: 2 drugs: AFATINIB reactions: Decreased appetite, Fatigue, Nausea, Rash, Stomatitis serious: 1 patientsex: 1 drugs: ACYCLOVIR, BUSULFAN, CYCLOSPORINE, CYCLOSPORINE HYDROCHLORIDE, CYCLOSPORINE HYDROCHLORIDE, CYCLOSPORINE HYDROCHLORIDE, CYCLOSPORINE HYDROCHLORIDE, CYCLOSPORINE HYDROCHLORIDE, CYCLOSPORINE HYDROCHLORIDE, CYCLOSPORINE HYDROCHLORIDE, CYCLOSPORINE HYDROCHLORIDE, CYCLOSPORINE HYDROCHLORIDE, CYCLOSPORINE HYDROCHLORIDE, CYCLOSPORINE HYDROCHLORIDE, CYCLOSPORINE HYDROCHLORIDE, CYCLOSPORINE HYDROCHLORIDE, CYCLOSPORINE HYDROCHLORIDE, CYCLOSPORINE HYDROCHLORIDE, serious: 1 patientsex: 2 drugs: EMPAGLIFLOZIN, INSULIN GLARGINE, METFORMIN HYDROCHLORIDE reactions: Diabetic ketoacidosis serious: 1 patientsex: 1 drugs: ANAKINRA, ETANERCEPT, CYCLOSPORINE, DAPSONE, METHOTREXATE, PREDNISOLONE reactions: Drug effect incomplete, Injection site reaction serious: 1 patientsex: 1 drugs: IPILIMUMAB, METHYLPREDNISOLONE, PREDNISOLONE reactions: Cytomegalovirus enterocolitis serious: 1 patientsex: 1 drugs: CYCLOPHOSPHAMIDE, DOXORUBICIN, PREDNISOLONE, RITUXIMAB, VINCRISTINE reactions: Burkitts lymphoma, Febrile neutropenia, Neutropenia, Pneumonia, Pyrexia, Rash, Thrombocytopenia serious: 1 patientsex: 2 drugs: ASPARAGINASE, DAUNORUBICIN, METHOTREXATE, PREDNISONE, VINCRISTINE reactions: Hydrocephalus serious: 1 patientsex: 2 drugs: PROPYLTHIOURACIL reactions: Lupus-like syndrome, Pulmonary alveolar haemorrhage, Respiratory failure serious: 1 patientsex: 2 drugs: ALBUTEROL, AZITHROMYCIN ANHYDROUS, CEFTRIAXONE, FLUTICASONE PROPIONATESALMETEROL XINAFOATE, METHYLPREDNISOLONE, METOPROLOL SUCCINATE, RITUXIMAB, TORSEMIDE reactions: Cardiogenic shock, Drug ineffective, Myocarditis aspergillus, Renal failure serious: 2 patientsex: 1 drugs: PRIMIDONE, PROPRANOLOL HYDROCHLORIDE, TOPIRAMATE reactions: Drug ineffective serious: 1 patientsex: 2 drugs: METHYLPREDNISOLONE, PREDNISOLONE, SQUARIAC ACID DIBUTYLESTER reactions: Osteonecrosis of the femur serious: 1 patientsex: 2 drugs: TACROLIMUS reactions: Idiopathic intracranial hypertension serious: 1 patientsex: 2 drugs: ZOLEDRONIC ACID reactions: Osteonecrosis of jaw serious: 1 patientsex: 1 drugs: CARBOPLATIN, EPIRUBICIN, KETOCONAZOLE, RAMIPRIL, OCTREOTIDE reactions: Febrile neutropenia, Intestinal perforation, Psychotic disorder serious: 1 patientsex: 2 drugs: METHYLPREDNISOLONE, MYCOPHENOLATE MOFETIL, TACROLIMUS reactions: Basal cell carcinoma, Cryptococcal cutaneous infection, Drug ineffective, Granulomatous inflammation, Infection, Skin lesion, Skin ulcer, Skin plaque, Skin plaque, Skin scar serious: 1 patientsex: 1 drugs: ASPIRIN, CYCLOPHOSPHAMIDE, DEXAMETHASONE, METHYLPREDNISOLONE, PREDNISONE, VALACYCLOVIR HYDROCHLORIDE reactions: Cystoid macular oedema, Drug ineffective, Retinal haemorrhage, Visual acuity reduced serious: 1 patientsex: 1 drugs: MYCOPHENOLATE MOFETIL, PREDNISOLONE, TACROLIMUS reactions: Hydronephrosis, Nephrolithiasis, Pyrexia, Renal tract calculus serious: 1 patientsex: 1 drugs: CIPROFLOXACIN, CEFOTAXIME SODIUM, GOSERELIN, HYDROXYCHLOROQUINE, LOPINAVIRRITONAVIR, MEROPENEM, NOREPINEPHRINE, PREDNISOLONE, TOCILIZUMAB reactions: Drug ineffective, Off label use serious: 1 patientsex: 1 drugs: BETAMETHASONE, MAGNESIUM, PREDNISONE reactions: Foetal exposure during pregnancy, Premature baby, Thrombotic thrombocytopenic purpura serious: 1 patientsex: 2 drugs: LINEZOLID, LEVOFLOXACIN, SULFAMETHOXAZOLETRIMETHOPRIM reactions: Tendon disorder serious: 1 patientsex: 2 drugs: ALENDRONATE SODIUM, LANTHANUM CARBONATE reactions: Drug ineffective serious: 1 patientsex: 2 drugs: CYTARABINE, METHOTREXATE reactions: Aplasia, Bone marrow failure, Pancytopenia, Respiratory failure, Stenotrophomonas infection serious: 1 patientsex: 1 drugs: CARBOPLATIN, ETOPOSIDE, IFOSFAMIDE, RITUXIMAB reactions: Cellulitis, Febrile neutropenia, West Nile viral infection serious: 1 patientsex: 1 drugs: MEDROXYPROGESTERONE ACETATE, TIZANIDINE, THORIODAZINE reactions: Priapism serious: 1 patientsex: 2 drugs: BUSULFAN, CYCLOPHOSPHAMIDE, CYCLOSPORINE, DEXAMETHASONE, EMAPALAMAB, FLUDARABINE PHOSPHATE, METHYLPREDNISOLONE, PREDNISONE, THIOTEPA, THYMOCYTE IMMUNE GLOBULIN NOS reactions: Polymyositis serious: 1 patientsex: 1 drugs: OLANZAPINE, QUETIAPINE, SERTRALINE HYDROCHLORIDE, TOPIRAMATE reactions: Priapism serious: 1 patientsex: 2 drugs: FOLIC ACID reactions: Folate deficiency, Unmetabolised folate syndrome serious: 1 patientsex: 2 drugs: ASPIRIN, BUDESONIDE, CYCLOSPORINE, METHYLPREDNISOLONE, PREDNISOLONE, RITUXIMAB, VINCRISTINE reactions: Meningioma serious: 1 patientsex: 2 drugs: FINGOLIMOD HYDROCHLORIDE reactions: Herpes zoster serious: 1 patientsex: 1 drugs: ASPIRIN, CLOPIDOGREL BISULFATE, WARFARIN reactions: Acute respiratory failure, Pulmonary alveolar haemorrhage serious: 1 patientsex: 2 drugs: ARIPIPRAZOLE, METHYLPHENIDATE HYDROCHLORIDE reactions: Weight increased serious: 1 patientsex: 2 drugs: ALBUTEROL, NICARDIPINE reactions: Acute pulmonary oedema, Back pain, Headache, Hypoventilation, Photophobia, Visual disorder serious: 1 patientsex: 1 drugs: BASILIXIMAB, ETANERCEPT, MYCOPHENOLATE MOFETIL reactions: Graft versus host disease serious: 1 patientsex: 1 drugs: CISPLATIN, FLUOROURACIL reactions: Aortic pseudoaneurysm, Cough haemorrhagic, Haematemesis, Leukocytosis, Pneumonia, Respiratory failure, Septic shock serious: 2 patientsex: 1 drugs: ALPRAZOLAM, CLONAZEPAM, HYDROXYZINE HYDROCHLORIDE, MIRTAZAPINE, SERTRALINE HYDROCHLORIDE, VENLAFAXINE HYDROCHLORIDE reactions: Drug dependence, Drug intolerance, Major depression, Suicidal ideation serious: 1 patientsex: 2 drugs: CLOZAPINE, TETRABENAZINE reactions: Hallucination, Suicidal ideation serious: 1 patientsex: 1 drugs: BLEOMYCIN SULFATE, DACARBAZINE, DOXORUBICIN, VINBLASTINE reactions: Interstitial lung disease serious: 1 patientsex: 1 drugs: CARBOPLATIN, FRAXIPARINE, LORAZEPAM, PIPERIDOPRIL HYDROCHLORIDE, ROSUVASTATIN reactions: Acute respiratory failure, Pericardial effusion serious: 1 patientsex: 1 drugs: METHOTREXATE reactions: Drug ineffective serious: 1 patientsex: 2 drugs: BLEOMYCIN SULFATE, CISPLATIN, ETOPOSIDE reactions: Organising pneumonia serious: 1 patientsex: 2 drugs: AMIODARONE, BISOPROLOL, INSULIN NOS, LIDOCAINE, MEROPENEM, NOREPINEPHRINE reactions: Drug ineffective serious: 1 patientsex: 2 drugs: CILOSTAZOL, HYDROCHLOROTHIAZIDE, HEPARIN SODIUM, TRICLOPIDINE reactions: Haematoma muscle serious: 1 patientsex: 1 drugs: METHYLPREDNISOLONE, MYCOPHENOLATE MOFETIL, PREDNISONE, TACROLIMUS reactions: Anaemia, Fatigue, Hepatitis C, Insomnia serious: 1 patientsex: 2 drugs: AMLODIPINE BESYLATE reactions: Atypical mucoepidermoid carcinoma, Gingival hypertrophy serious: 1 patientsex: 2 drugs: MYCOPHENOLIC ACID, PREDNISONE, TACROLIMUS, VALGANCICLOVIR reactions: Acrophaeohyphomycosis, Brain abscess, Neutropenia serious: 1 patientsex: 1 drugs: IPILIMUMAB, NIVOLUMAB reactions: Hypophysitis, Multiple organ dysfunction syndrome, Secondary adrenocortical insufficiency serious: 1 patientsex: 2 drugs: METFORMIN HYDROCHLORIDE reactions: Blindness transient, Lactic acidosis serious: 1 patientsex: 1 drugs: CISPLATIN, DEXAMETHASONE, DOXORUBICIN HYDROCHLORIDE, IFOSFAMIDE reactions: Neutropenia serious: 1 patientsex: 2 drugs: APATINIB reactions: Palmar-plantar erythrodysaesthesia syndrome serious: 1 patientsex: 1 drugs: ACETAMINOPHEN, AMLODIPINE BESYLATE, IBUPROFEN, METHOTREXATE reactions: Abdominal pain, Decreased appetite, Nausea, Pancytopenia, Stomatitis, Skin ulcer, Vomiting serious: 1 patientsex: 2 drugs: CEFUROXIME reactions: Lichen planus serious: 1 patientsex: 1 drugs: FUROSEMIDE, METHYLPREDNISOLONE, MYCOPHENOLATE MOFETIL, PREDNISOLONE reactions: Osteonecrosis, Myopathy, Vertebral fracture serious: 1 patientsex: 1 drugs: CYTARABINE, DAUNORUBICIN reactions: Optic neuropathy, Maculopathy serious: 1 patientsex: 1 drugs: ADALIMUMAB, CALCIOPTRIOL, CYCLOSPORINE, METHOTREXATE reactions: Malaise serious: 1 patientsex: 2 drugs: DEXAMETHASONE, TRABECTEDIN reactions: Alanine aminotransferase increased, Alanine aminotransferase increased, Alanine aminotransferase increased, Alanine aminotransferase increased, Alanine aminotransferase increased, Alanine aminotransferase increased, Alanine aminotransferase increased, Alanine aminotransferase increased, Alanine aminotransferase increased, Alanine aminotransferase increased, Alanine aminotransferase increased, Alanine aminotransferase increased, Alanine aminotransferase increased, Alanine aminotransferase increased, Alanine aminotransferase increased, Alanine aminotransferase increased, Alanine aminotransferase increased, Alanine aminotransferase increased, Alanine aminotransferase increased, Alanine aminotransferase increased, Alanine aminotransferase increased, Alanine aminotransferase increased, Alanine aminotransferase increased, Alan serious: 1 patientsex: 1 drugs: SILDENAFIL reactions: Cardiac failure, Cardiomegaly, Drug use issue serious: 1 patientsex: 1 drugs: CYCLOPHOSPHAMIDE, MERCAPTOPURINE, METHOTREXATE, IMATINIB MESYLATE reactions: Constipation, Febrile neutropenia, Pneumonia serious: 1 patientsex: 2 drugs: BINIMETINIB reactions: Acne, Drug resistance, Eye pressure increased, Myalgia, Retinopathy serious: 1 patientsex: 2 drugs: PEMBROLIZUMAB reactions: Pancytopenia serious: 1 patientsex: 1 drugs: NATALIZUMAB reactions: Cytomegalovirus infection serious: 1 patientsex: 1 drugs: ASPIRIN, GLYCERIN, ISOSORBIDE DINITRATE, METFORMIN HYDROCHLORIDE reactions: Bradycardia, Confusional state, Lactic acidosis, Shock serious: 1 patientsex: 1 drugs: CISPLATIN, DOCETAXEL, FLUCONAZOLE reactions: Febrile neutropenia serious: 1 patientsex: 1 drugs: DABIGATRAN ETEXILATE MESYLATE reactions: Rectal haemangioma serious: 1 patientsex: 1 drugs: AMIKACIN, CIDOFOVIR, CYCLOSPORINE, DEXAMETHASONE, FOSCARNET, GANCICLOVIR, OCTREOTIDE, VANCOMYCIN reactions: Drug ineffective, Drug resistance, Multiple organ dysfunction syndrome, Shock serious: 1 patientsex: 1 drugs: AMPICILLIN SODIUMSULBACTAM SODIUM, HEPARIN SODIUM, METRONIDAZOLE, WARFARIN reactions: Drug ineffective serious: 1 patientsex: 1 drugs: PEMBROLIZUMAB reactions: Acute kidney injury, Autoimmune hepatitis, Eosinophilia, Tubulointerstitial nephritis serious: 1 patientsex: 1 drugs: ADALIMUMAB, GOLIMUMAB, LEFLUNOMIDE, METHOTREXATE, PREDNISONE, SULFASALAZINE reactions: IgA nephropathy serious: 1 patientsex: 2 drugs: CYCLOPHOSPHAMIDE, DOXORUBICIN, VINCRISTINE reactions: Febrile neutropenia, Oral stomatitis, Pancytopenia serious: 1 patientsex: 1 drugs: SERTRALINE HYDROCHLORIDE reactions: Apnoia, Exposure during pregnancy, Neonatal abstinence syndrome, Skin colour pale, Skin opacity, Vomiting serious: 1 patientsex: 1 drugs: TACROLIMUS reactions: Inflammatory bowel disease serious: 1 patientsex: 1 drugs: BICALUTAMIDE, LEUPROLIDE ACETATE reactions: Drug ineffective serious: 1 patientsex: 2 drugs: HUMAN IMMUNOGLOBULIN G, METHYLPREDNISOLONE, PYRIDOSTIGMINE reactions: Drug ineffective, Multiple organ dysfunction syndrome, Respiratory failure serious: 1 patientsex: 2 drugs: LACOSAMIDE, KETAMINE, MIDAZOLAM HYDROCHLORIDE, PHENYTOIN, TOPIRAMATE, PROPOFOL reactions: Drug-induced liver injury, Off label use serious: 1 patientsex: 1 drugs: CYCLOSPORINE, ENOXAPARIN, PREDNISONE reactions: Pulmonary embolism serious: 1 patientsex: 2 drugs: MYCOPHENOLATE MOFETIL, PREDNISOLONE, TACROLIMUS reactions: Acute kidney injury, Glomerulonephritis, Tubulointerstitial nephritis serious: 1 patientsex: 2 drugs: DIAZEPAM, OLANZAPINE, VALPROIC ACID reactions: Anaemia, Drug ineffective, Hypercholesterolaemia, Maternal exposure during pregnancy, Psychomotor hyperactivity, Sedation, Treatment noncompliance serious: 1 patientsex: 1 drugs: AMIODARONE, DIGOXIN, LEVOFLOXACIN, MEROPENEM, METHYLPREDNISOLONE, PENICILLIN G reactions: Drug ineffective serious: 1 patientsex: 1 drugs: CABERGOLINE reactions: Drug resistance, Rhinorrhoea serious: 1 patientsex: 1 drugs: ASPIRIN, BUDESONIDE, CIPROFLOXACIN, CIPROFLOXACIN HYDROCHLORIDE, CIPROFLOXACIN HYDROCHLORIDE, CIPROFLOXACIN HYDROCHLORIDE, CIPROFLOXACIN HYDROCHLORIDE, CIPROFLOXACIN HYDROCHLORIDE, CIPROFLOXACIN HYDROCHLORIDE, CIPROFLOXACIN HYDROCHLORIDE, CIPROFLOXACIN HYDROCHLORIDE, CIPROFLOXACIN HYDROCHLORIDE, CIPROFLOXACIN HYDROCHLORIDE, CIPROFLOXACIN HYDROCHLORIDE, CIPROFLOXACIN HYDROCHLORIDE, CIPROFLOXACIN HYDROCHLORIDE, CIPROFLOXACIN HYDROCHLORIDE, CI serious: 1 patientsex: 1 drugs: BICALUTAMIDE, METHOTREXATE reactions: Antiandrogen withdrawal syndrome serious: 1 patientsex: 1 drugs: ALENDAZOLE, CARBAMAZEPINE, DEXAMETHASONE, PRAZIQUANTEL reactions: Conjunctival hyperaemia, Drug ineffective, Eye pain, Ocular cysticercosis, Pain in eye, Seizure serious: 1 patientsex: 2 drugs: CLONAZEPAM, CITALOPRAM HYDROBROMIDE, FENTANYL, OXYCODONE HYDROCHLORIDE reactions: Constipation serious: 1 patientsex: 2 drugs: METFORMIN HYDROCHLORIDE reactions: Vitamin B12 deficiency serious: 1 patientsex: 2 drugs: ASPIRIN, CABERGOLINE, CYDROGESTERONE, ESTRADIOL reactions: Drug ineffective, Ovarian hyperstimulation syndrome serious: 1 patientsex: 2 drugs: IBUPROFEN reactions: Pulmonary hypertension serious: 1 patientsex: 2 drugs: AZATHIOPRINE, METHYLPREDNISOLONE, MYCOPHENOLATE MOFETIL, TACROLIMUS reactions: Acute kidney injury, Exposure during pregnancy serious: 1 patientsex: 1 drugs: CISPLATIN, SODIUM THIOSULFATE reactions: Osteonecrosis serious: 1 patientsex: 1 drugs: FUROSEMIDE, SPIRONOLACTONE, TOLVAPTAN reactions: Drug ineffective, Drug interaction, Hepatic cirrhosis, Hepatic oedema, Hepatic cirrhosis recurrent, Hepatic cirrhosis, Hepatic cirrhosis recurrent, Hepatic cirrhosis recurrent, Hepatic cirrhosis recurrent, Hepatic cirrhosis recurrent, Hepatic cirrhosis recurrent, Hepatic cirrhosis recurrent, Hepatic cirrhosis recurrent, Hepatic cirrhosis recurrent, Hepatic cirrhosis recurrent, Hepatic cirrhosis recurrent, Hepatic cirrhosis recurrent, Hepatic cirrhosis recurrent, Hepatic cirrhosis recurrent, Hepatic cirrhosis recurrent, Hepatic cirrhosis recurrent, He serious: 1 patientsex: 1 drugs: AMLODIPINE BESYLATE reactions: Bradycardia, Hypercalcaemia, Hypotension, Intentional overdose, Pancreatitis, Suicide attempt serious: 1 patientsex: 1 drugs: COLISTIN, MEROPENEM, TIGECYCLINE reactions: Drug ineffective serious: 1 patientsex: 1 drugs: CISPLATIN, GEMCITABINEGEMCITABINE HYDROCHLORIDE reactions: Drug ineffective serious: 1 patientsex: 1 drugs: AZITHROMYCIN ANHYDROUS, DOXYCYCLINE, MEROPENEM, OSELTAMIVIR, TEICOPLANIN reactions: Candida infection, Nocardiosis, Respiratory failure serious: 1 patientsex: 2 drugs: BROMOCRIPTINE reactions: Amenorrhoea, Arthralgia, Drug ineffective, Fatigue, Pituitary microadenoma, Raynauds phenomenon, Weight decreased serious: 1 patientsex: 2 drugs: METHADONE HYDROCHLORIDE reactions: Accidental exposure to product by child, Electrocardiogram QT prolonged, Loss of consciousness, Miosis, Somnolence, Toxicity to various agents serious: 1 patientsex: 1 drugs: ASPIRIN, CLOPIDOGREL BISULFATE, METHYLPREDNISOLONE, METHYLPREDNISOLONE SODIUM SUCCINATE, WARFARIN reactions: Drug interaction, Drug level decreased, Drug level increased, Drug level decreased, Drug level increased, Drug level decreased, Drug level increased, Drug level decreased, Drug level increased, Drug level decreased, Drug level increased, Drug level decreased, Drug level increased, Drug level decreased, Drug level increased, Drug level decreased, Drug level increased, Drug level decreased, Drug level increased, Drug level decreased, Drug level increased, Drug level decreased, Drug level increased, Drug level decreased, Drug level increased, Drug level decreased, Drug level increased, Drug level decreased, Drug level increased, Drug level decreased, Drug level increased, Drug level decreased, Drug level increased, Drug level decreased, Drug level increased, Drug level decreased, Drug level increased, Drug level decreased, Drug level increased, Drug level decreased, Drug level increased, Drug level decreased, Drug level increased, Drug level decreased, Drug level increased, Drug level decreased, Drug level increased, Drug level decreased, Drug level increased serious: 1 patientsex: 1 drugs: CLOBETASOL PROPIONATE reactions: Adrenal insufficiency, Adrenal suppression, Adrenal suppression induced, Adrenal insufficiency, Adrenal suppression, Adrenal insufficiency, Adrenal suppression, Adrenal insufficiency, Adrenal suppression, Adrenal insufficiency, Adrenal suppression, Adrenal insufficiency, Adrenal insufficiency, Adrenal suppression, Adrenal insufficiency, Adrenal insufficiency, Adrenal insufficiency, Adrenal insufficiency, Adrenal insufficiency, Adrenal insufficiency, Adrenal insufficiency, Adrenal insufficiency, Adrenal insufficiency, Adrenal insufficiency, Adrenal insufficiency, Adrenal insufficiency, Adrenal insufficiency, Adrenal insufficiency, Adrenal insufficiency, serious: 1 patientsex: 1 drugs: ACENOCOUMAROL, ATORVASTATIN, ENOXAPARIN, INSULIN NOS, LEVOTHYROXINE, METOPROLOL, LISINOPRIL, METOPROLOL SUCCINATE, SPIRONOLACTONE, SIMVASTATIN reactions: Acute kidney injury, Drug interaction, Gastrointestinal haemorrhage, Non-ST segment elevation myocardial infarction serious: 1 patientsex: 2 drugs: AMPHOTERICIN B, DEXAMETHASONE, MEROPENEM, VANCOMYCIN reactions: Drug ineffective serious: 1 patientsex: 2 drugs: LEVOFLOXACIN reactions: Skin hyperpigmentation serious: 1 patientsex: 1 drugs: NIVOLUMAB reactions: Alopecia, Asthenia, Bone pain, Dyspnoea, Fatigue, Hepatic enzyme increased, Hepatic function abnormal, Metastases to central nervous system, Nausea, Neutropenia, Neutropenia, Neutropenia, Neutropenia, Neutropenia, Neutropenia, Neutropenia, Neutropenia, Neutropenia, Neutropenia, Neutropenia, Neutropenia, Neutropenia, Neutropenia, Neutropenia, Neutropenia, Neutropenia, Neutropenia, Neutropenia, Neutropenia, Neutropenia, Neutropenia, Neutropenia, Neutropenia, Neutropenia, Neutropenia, Neutropenia, Neutropenia, Neutropenia, Neutropenia, Neutropenia, Neutropenia, Neutropenia, Neutropenia, Neutropenia, Neutropenia, Neutropenia, Neutropenia, Neutropenia, Neutropenia, Neutropenia, Neutropenia, Neutropenia, Neutropenia, Neutropenia, Neutropenia, Neutropenia, Neutropenia, serious: 1 patientsex: 1 drugs: CARBOPLATIN reactions: Malignant neoplasm progression serious: 1 patientsex: 1 drugs: CARBAMAZEPINE reactions: Aortopulmonary artery malformation, Foetal exposure during pregnancy serious: 1 patientsex: 2 drugs: HUMAN THYMOCYTE IMMUNE GLOBULIN reactions: Hypothyroidism, Thyroiditis serious: 1 patientsex: 1 drugs: BEVACIZUMAB, CARBOPLATIN, PACLITAXEL reactions: Atelectasis, Malignant neoplasm progression, Metastases to central nervous system, Seizure, Tumour lysis syndrome serious: 1 patientsex: 1 drugs: PREDNISOLONE, TACROLIMUS reactions: Dengue fever, Toxicity to various agents serious: 1 patientsex: 1 drugs: CISPLATIN, PACLITAXEL reactions: Bone marrow failure serious: 1 patientsex: 1 drugs: AZITHROMYCIN ANHYDROUS, DEXAMETHASONE, FAVIPIRAVIR, PIPERACILLIN SODIUMTAZOBACTAM SODIUM reactions: Acute kidney injury, Acute respiratory distress syndrome, Acute kidney injury, Acute kidney injury, Cardiac arrest, Hepatitis fulminant, Multiple organ dysfunction syndrome, Myocarditis, Off label use, Product use in unapproved indication, Systemic inflammatory response syndrome serious: 1 patientsex: 2 drugs: BLEOMYCIN SULFATE, CISPLATIN, ETOPOSIDE reactions: Pancytopenia serious: 1 patientsex: 2 drugs: CIDOFOVIR, MEFLOUINE, MIRTAZAPINE reactions: Drug ineffective serious: 1 patientsex: 1 drugs: MILTEFOSINE reactions: Iridocyclitis serious: 1 patientsex: 1 drugs: DALBAVANCIN reactions: Off label use, Renal impairment serious: 1 patientsex: 1 drugs: CISPLATIN, DOCETAXEL reactions: Immunodeficiency serious: 1 patientsex: 2 drugs: AMIODARONE HYDROCHLORIDE, WARFARIN reactions: Pulmonary alveolar haemorrhage, Pulmonary toxicity serious: 1 patientsex: 1 drugs: QUETIAPINE, VALPROIC ACID reactions: Akathisa, Drug abuse, Dyskinesia, Myoclonus, Neurotoxicity, Restlessness serious: 1 patientsex: 2 drugs: ASPIRIN, ATORVASTATIN, CLOPIDOGREL BISULFATE, FOLIC ACID, CITALOPRAM HYDROBROMIDE, LEVOTHYROXINE, RANITIDINE, ZOPICLONE reactions: Electrocardiogram QT prolonged, Torsade de pointes serious: 1 patientsex: 1 drugs: AFATINIB reactions: Drug resistance serious: 1 patientsex: 1 drugs: AMLODIPINE BESYLATE, ATORVASTATIN CALCIUM reactions: Drug interaction, Rhabdomyolysis serious: 1 patientsex: 1 drugs: PREDNISOLONE, TACROLIMUS reactions: Peripheral T-cell lymphoma, Splenomegaly serious: 1 patientsex: 2 drugs: SORAFENIB reactions: Rash serious: 1 patientsex: 1 drugs: ASPIRIN, CIPROFLOXACIN, FUROSEMIDE, LEVOFLOXACIN, METOPROLOL, SIMVASTATIN reactions: Drug interaction, Rhabdomyolysis serious: 1 patientsex: 2 drugs: ACENOCOUMAROL, AMLODIPINE BESYLATE reactions: Subdural haematoma serious: 1 patientsex: 1 drugs: CYCLOPHOSPHAMIDE, CYTARABINE, DEXAMETHASONE, ETOPOSIDE, HUMAN IMMUNOGLOBULIN G, RITUXIMAB, VALACYCLOVIR HYDROCHLORIDE reactions: Anaemia, C-reactive protein increased, Cough, Cough pyramidal, C-reactive protein increased, Cough, Cough opacity, C-reactive protein increased, C-reactive protein increased, C-reactive protein increased, Cough, C-reactive protein increased, C-reactive protein increased, Cough, C-reactive protein increased, C-reactive protein increased, Cough, Cough, C-reactive protein increased, Cough, Cough, Cough, Cough, Cough, Cough, Cough, Cough, Cough, Cough, Cough, Cough, Cough, Cough, Cough, Cough, Cough, Cough, Cough, Cough, Cough, Cough, Cough, Cough, Cough, Cough, C serious: 1 patientsex: 2 drugs: PEMBROLIZUMAB reactions: Disease progression serious: 1 patientsex: 2 drugs: BEVACIZUMAB, CISPLATIN, GEMCITABINEGEMCITABINE HYDROCHLORIDE reactions: Haemorrhage serious: 1 patientsex: 1 drugs: METHADONE HYDROCHLORIDE reactions: Acute kidney injury, Drug abuse, Hypotension, Myoclonus, Respiratory failure, Somnolence serious: 1 patientsex: 2 drugs: CYCLOPHOSPHAMIDE, DOXORUBICIN, PREDNISONE, VINCRISTINE reactions: Tumour lysis syndrome, Wound perforation serious: 1 patientsex: 1 drugs: CETUXIMAB, FLUOROURACIL, ENTECAVIR, NIVOLUMAB, PREDNISOLONE reactions: Drug resistance, Hepatitis serious: 1 patientsex: 2 drugs: BOTULINUM TOXIN TYPE A reactions: Botulism, Toxicity to various agents serious: 1 patientsex: 2 drugs: AMLODIPINE BESYLATE, BISOPROLOL, INSULIN NOS, LISINOPRIL reactions: Cytomegalovirus infection, Drug ineffective, Toxic epidermal necrolysis serious: 1 patientsex: 1 drugs: CANADINE HYDROCHLORIDE, GLIPIZIDE, INSULIN NOS, METFORMIN HYDROCHLORIDE reactions: Diabetic ketoacidosis serious: 1 patientsex: 1 drugs: AMLODIPINE BESYLATE, ASPIRIN, ATORVASTATIN, CLOPIDOGREL BISULFATE, HYDROXYCHLOROQUINE, LEVETIRACETAM, METFORMIN HYDROCHLORIDE reactions: Acute kidney injury, Ischaemic stroke serious: 1 patientsex: 2 drugs: ASPIRIN, CLOPIDOGREL BISULFATE reactions: Mediastinal haemorrhage serious: 1 patientsex: 2 drugs: CYTARABINE, DASATINIB reactions: Pancreatitis acute serious: 1 patientsex: 2 drugs: AMOXICILLIN, CLAVULANIC ACID, METRONIDAZOLE reactions: Toxic encephalopathy serious: 1 patientsex: 1 drugs: GEMCITABINE reactions: Haematemesis serious: 1 patientsex: 2 drugs: CHLORAMBUCIL, CYCLOSPORINE, FUROSEMIDE, MYCOPHENOLIC ACID, PREDNISONE reactions: Cytomegalovirus colitis serious: 1 patientsex: 1 drugs: MYCOPHENOLATE MOFETIL, PREDNISONE, TACROLIMUS reactions: BK virus infection, Basal cell carcinoma, Bladder adenopathy, Haematuria, Urothelial adenocarcinoma, Ureteric adenopathy, Urosepsis serious: 1 patientsex: 1 drugs: ESTRAMUSTINE reactions: Cardiac failure serious: 1 patientsex: 1 drugs: ADALIMUMAB, AZATHIOPRINE, INFLIXIMAB, MESALAMINE, METRONIDAZOLE, PREDNISONE, THALIDOMIDE reactions: Schizophrenia serious: 1 patientsex: 2 drugs: DENOSUMAB, PACLITAXEL, TRASTUZUMAB, ZOLEDRONIC ACID reactions: Cardiotoxicity, Drug ineffective, Neuropathy peripheral serious: 1 patientsex: 2 drugs: ACETAMINOPHENMETOCLOPRAMIDE, CINNARIZINE, DIMENHYDRAMINE, METOCLOPRAMIDE reactions: Toxic epidermal necrolysis serious: 1 patientsex: 2 drugs: ASPIRIN, BETAXOLOL, BUDESONIDE, CYCLOPHOSPHAMIDE, HYDROCORTISONE, METHYLPREDNISOLONE, PREDNISOLONE, RITUXIMAB, VINCRISTINE reactions: Drug ineffective, Drug ineffective for unapproved indication, Off label use serious: 1 patientsex: 1 drugs: BENDAMUSTINE HYDROCHLORIDE, CYCLOPHOSPHAMIDE, DOXORUBICIN, PREDNISONE, RITUXIMAB, VINCRISTINE reactions: Drug ineffective, Drug resistance, Infection, Lymphadenopathy, Night sweats, Night sweats abnormal, Night sweats serious: 1 patientsex: 2 drugs: ACETAMINOPHEN, ACETAMINOPHENCLAVULANIC ACID, ACETAMINOPHENCLAVULANIC ACID, DICLOFENAC, CEFTAZIDIME, ENOXAPARIN, TRAMADOL reactions: Dermatitis bullous, Haemorrhagic serious: 1 patientsex: 1 drugs: DEXAMETHASONE, DOCETAXEL reactions: Interstitial lung disease serious: 1 patientsex: 2 drugs: ASPIRIN, BIOTIN, LISINOPRIL, METOPROLOL, ZINC reactions: Anaemia, Copper deficiency, Cytopenia serious: 1 patientsex: 1 drugs: GLATIRAMER ACETATE reactions: Bone marrow failure, Myelotoxicity serious: 1 patientsex: 1 drugs: CLONIDINE, EPLERENONE, FINASTERIDE, FUROSEMIDE, TAMULOSIN, WARFARIN reactions: Anaemia, Bronchospasm, Coagulopathy, Drug reaction with eosinophilia and systemic symptoms serious: 1 patientsex: 2 drugs: MYCOPHENOLATE MOFETIL, PREDNISONE, TACROLIMUS reactions: Cerebral toxoplasmosis, Cytomegalovirus infection, Epstein-Barr virus infection, Pneumonia cytomegaloviral serious: 1 patientsex: 2 drugs: CYCLOPHOSPHAMIDE, DOXORUBICIN HYDROCHLORIDE, FLUOROURACIL reactions: Aspergillus infection, Small intestinal infarction serious: 1 patientsex: 2 drugs: DOXORUBICIN HYDROCHLORIDE, IFOSFAMIDE reactions: Nausea, Leukopenia, Thrombocytopenia serious: 1 patientsex: 1 drugs: CYCLOPHOSPHAMIDE, PREDNISONE, LANREOTIDE reactions: Anaemia, Fatigue, Renal impairment serious: 1 patientsex: 2 drugs: DABIGATRAN ETEXILATE MESYLATE, RIVAROXABAN reactions: Drug ineffective, Joint pain serious: 1 patientsex: 2 drugs: CALCIUM, MAGNESIUM reactions: Condition aggravated, Drug ineffective serious: 1 patientsex: 1 drugs: CO2 reactions: Abdominal pain, Abdominal pain upper, Abdominal pain lower, Cat scratch colon, Bladder, Urine, Peritoneal disorder, Pneumoperitoneum, Serosal tear, Urine output decreased serious: 1 patientsex: 2 drugs: BUPROPION, DULOXETINE, INSULIN GLARGINE, MIRTAZAPINE, PRAZOSIN, TRAZODONE HYDROCHLORIDE reactions: Drug ineffective, Hypoglycaemia, Intentional overdose, Suicide attempt serious: 1 patientsex: 2 drugs: HUMAN IMMUNOGLOBULIN G, METFORMIN HYDROCHLORIDE reactions: Exposure during pregnancy, Hepatic enzyme increased, Premature delivery, Respiratory distress serious: 1 patientsex: 1 drugs: BACLOFEN reactions: Drug dependence, Drug withdrawal syndrome, Drug dependence serious: 1 patientsex: 1 drugs: CYCLOSPORINE, MYCOPHENOLIC ACID, PREDNISONE, USTEKINUMAB reactions: Gastrointestinal disorder, Hypertension, Swelling serious: 1 patientsex: 2 drugs: OMEPRAZOLE, SITAGLIPTIN reactions: Autoimmune hepatitis, Drug-induced liver injury serious: 1 patientsex: 1 drugs: NITISINONE reactions: Acute hepatic failure, Cognitive disorder serious: 1 patientsex: 1 drugs: CISPLATIN, GEMCITABINEGEMCITABINE HYDROCHLORIDE reactions: Acute kidney injury, Atrial arrhythmia, Hypotension, Listeriosis, Peritonitis bacterial serious: 1 patientsex: 1 drugs: CYCLOPHOSPHAMIDE, DOXORUBICIN HYDROCHLORIDE, PREDNISOLONE, VINCRISTINE reactions: COVID-19 serious: 1 patientsex: 2 drugs: MEROPENEM, SULFAMETHOXAZOLETRIMETHOPRIM reactions: Drug ineffective, Hyponatraemia serious: 1 patientsex: 1 drugs: CYCLOSPORINE, FLUDARABINE PHOSPHATE, INFLIXIMAB, METHOTREXATE, METHYLPREDNISOLONE, THIOTEPA reactions: Hepatic failure, Graft versus host disease in skin, Hepatic failure, Hepatic encephalopathy, Neurotoxicity, Toxicity to various agents serious: 1 patientsex: 2 drugs: APXABAN, CABOZANTINIB, NIVOLUMAB, PAZOPANIB reactions: Duodenal ulcer, Upper gastrointestinal haemorrhage serious: 1 patientsex: 1 drugs: METHYLPREDNISOLONE, METHYLPREDNISOLONE SODIUM SUCCINATE reactions: Drug abuse, Hypertension, Myocardial infarction, Seizure serious: 1 patientsex: 2 drugs: ACETAMINOPHENTRAMADOL reactions: Osteoarthritis progressive serious: 1 patientsex: 2 drugs: CALCITRIOL, CALCIUM, CALCIUM CARBONATE, CALCIUM CHLORIDE, CALCIUM FLUDROCORTISONE, CALCIUM CARBONATE, CALCIUM CARBONATE, CALCIUM CARBONATE, CALCIUM CARBONATE, CALCIUM CARBONATE, CALCIUM CARBONATE, CALCIUM CARBONATE, CALCIUM CARBONATE, CALCIUM CARBONATE, CALCIUM CARBONATE, CALCIUM CARBONATE, CALCIUM CARBONATE, CALCIUM CARBONATE, CALCIUM CARBONATE, CALCIUM CARBONATE, CALCIUM CARBONATE, CALCIUM CARBONATE, CALCIUM CARBONATE, CALCIUM CARBONATE, CALCIUM CARBONATE, CALCIUM CARBONATE, CALCIUM CARBONATE, CALCIUM CARBON serious: 1 patientsex: 2 drugs: AZATHIOPRINE, PREDNISONE reactions: Drug abuse, Gastrointestinal disorder, Headache serious: 1 patientsex: 1 drugs: ASPIRIN, ATORVASTATIN, HEPARIN SODIUM, METOPROLOL TARTRATE, LISINOPRIL, WARFARIN reactions: Haemorrhagic infarction, Headache, Oedema vasogenic, Product use in unapproved indication serious: 1 patientsex: 1 drugs: DEXAMETHASONE, LEVETIRACETAM, METFORMIN HYDROCHLORIDE, TEMOZOLOMIDE reactions: Drug ineffective, Pulmonary embolism serious: 1 patientsex: 1 drugs: BEVACIZUMAB, IRINOTECAN, TEMOZOLOMIDE reactions: Bone marrow failure, Diarrhoea, Pyrexia, Respiratory failure serious: 1 patientsex: 1 drugs: LITHIUM, OLANZAPINE, RISPERIDONE reactions: Acute kidney injury, Delirium, Drug interaction, Nephropathy toxic, Neurotoxicity, Toxicity to various agents serious: 1 patientsex: 1 drugs: AZATHIOPRINE, MYCOPHENOLATE MOFETIL, TACROLIMUS reactions: Cardiomegaly, Interventricular septal hypertrophy serious: 1 patientsex: 1 drugs: OCRIPLASMIN reactions: Macular hole, Serous retinal detachment serious: 1 patientsex: 2 drugs: CLINDAMYCIN reactions: Erythema, Off label use, Product use issue serious: 1 patientsex: 2 drugs: ASPIRIN, ATORVASTATIN, CLOPIDOGREL BISULFATE, METOPROLOL, TICAGRELOR reactions: Myalgia serious: 1 patientsex: 1 drugs: CISPLATIN, FLUOROURACIL, TRASTUZUMAB reactions: Cerebral artery embolism, Jaundice serious: 1 patientsex: 2 drugs: CHOLECALCIFEROL, MAGNESIUM, MYCOPHENOLATE MOFETIL, PREDNISOLONE, RANITIDINE, SULFAMETHOXAZOLETRIMETHOPRIM, TACROLIMUS reactions: Acute kidney injury, Biliary obstruction, Drug level increased, Delirium, Hypertension, Nausea, Vomiting, Visual impairment, Toxicity to various agents serious: 1 patientsex: 2 drugs: FENTANYL, MORPHINE, TRAMADOL reactions: Drug ineffective, Drug withdrawal syndrome, Drug ineffective, Drug tolerance increased serious: 1 patientsex: 1 drugs: ADALIMUMAB, CERTOLIZUMAB PEGOL, METHOTREXATE, PREDNISONE reactions: Drug ineffective, Psoriatic arthropathy serious: 1 patientsex: 1 drugs: IMATINIB MESYLATE reactions: Acute myocardial infarction serious: 1 patientsex: 1 drugs: CALCIUM, DOCETAXEL, EPROSARTAN, FELODIPINE, GOSERELIN, SIMVASTATIN reactions: Atrial fibrillation, Fatigue, Palpitations, Toxicity to various agents serious: 1 patientsex: 2 drugs: MESALAMINE, PREDNISONE reactions: Atelectasis, Myocarditis serious: 1 patientsex: 1 drugs: CETUXIMAB, CISPLATIN, FLUOROURACIL reactions: Disease progression, Drug ineffective, Oedema peripheral, Oedema peripheral, Tracheal stenosis serious: 1 patientsex: 1 drugs: BICALUTAMIDE, ASPIRIN, TRIPTORELIN, TAMOXIFEN reactions: Brain hypoperfusion, Hemichorea, Hemiballism serious: 1 patientsex: 1 drugs: PREDNISONE reactions: Drug dependence, Nephrotic syndrome serious: 1 patientsex: 1 drugs: AZITHROMYCIN ANHYDROUS, CIPROFLOXACIN, CIPROFLOXACIN HYDROCHLORIDE, CIPROFLOXACIN HYDROCHLORIDE, CIPROFLOXACIN HYDROCHLORIDE, CIPROFLOXACIN HYDROCHLORIDE, CIPROFLOXACIN HYDROCHLORIDE, CIPROFLOXACIN HYDROCHLORIDE, CIPROFLOXACIN HYDROCHLORIDE, CIPROFLOXACIN HYDROCHLORIDE, CIPROFLOXACIN HYDROCHLORIDE, CIPROFLOXACIN HYDROCHLORIDE, CIPROFLOXACIN HYDROCHLORIDE, CIPROFLOXACIN HYDROCHLORIDE, CIPROFLOXACIN HYDROCHLORIDE, CIPROFLOXACIN HYDROCHLORIDE serious: 1 patientsex: 2 drugs: HYDROCORTISONE, TACROLIMUS reactions: Drug ineffective, Haemolytic uraemic syndrome, Pneumococcal infection, Respiratory failure serious: 1 patientsex: 1 drugs: AMPICILLIN SODIUMSULBACTAM SODIUM, FLUCONAZOLE reactions: Drug ineffective serious: 1 patientsex: 1 drugs: PREDNISONE, TACROLIMUS reactions: Hepatocellular carcinoma serious: 1 patientsex: 2 drugs: ACETAMINOPHEN, CARBAMAZEPINE, DEXMEDETOMIDINE, FLURBIPROFEN, LEVETIRACETAM, MIDAZOLAM HYDROCHLORIDE, PHENYTOIN, ROCURONIUM BROMIDE, SEVOFLURANE, VALPROIC ACID reactions: Drug ineffective, Status epilepticus serious: 1 patientsex: 2 drugs: ORLISTAT reactions: Acute kidney injury, Nephropathy oxalate serious: 1 patientsex: 1 drugs: MYCOPHENOLATE MOFETIL, PREDNISOLONE, TACROLIMUS reactions: Focal segmental glomerulosclerosis serious: 1 patientsex: 1 drugs: INSULIN GLARGINE, INSULIN LISPRO reactions: Amyloidosis, Hypoglycaemia, Subcutaneous haemorrhage serious: 1 patientsex: 1 drugs: AMIKACIN, COLISTIN, MEROPENEM, VANCOMYCIN reactions: Drug resistance serious: 1 patientsex: 2 drugs: PREDNISONE reactions: Angioedema acquired, Condition aggravated, Haematuria, Proteinuria, Supraventricular tachycardia serious: 1 patientsex: 1 drugs: AMIODARONE HYDROCHLORIDE reactions: Pulmonary toxicity serious: 1 patientsex: 2 drugs: METHOTREXATE reactions: Disease progression serious: 2 patientsex: 2 drugs: IBUPROFEN reactions: Drug interaction serious: 1 patientsex: 1 drugs: BASILIXIMAB, MYCOPHENOLATE MOFETIL, PREDNISONE, TACROLIMUS, VALGANCICLOVIR reactions: Aspergillus infection, Cytomegalovirus enterocolitis, Neutropenia serious: 1 patientsex: 1 drugs: BEVACIZUMAB, AFLIBERCEPT, RANIBIZUMAB reactions: Macular degeneration serious: 1 patientsex: 1 drugs: TRETINOIN reactions: Thrombocytosis serious: 1 patientsex: 1 drugs: ALPRAZOLAM, FENPYROXIME, VALPROIC ACID reactions: Gastrointestinal toxicity, Intentional product misuse, Metabolic acidosis, Toxicity to various agents serious: 1 patientsex: 1 drugs: DARUNAVIR, EMTRICITABINERILPIVIRINE, RALTEGRAVIR, RITONAVIR reactions: Drug ineffective, Hepatitis B, Immune dysfunction, Prescribed underdose serious: 1 patientsex: 2 drugs: ISONIAZID, NIFEDIPINE, THIOTINE reactions: Reversible cerebral vasoconstriction syndrome serious: 1 patientsex: 1 drugs: CYCLOPHOSPHAMIDE, DEXAMETHASONE, DOXORUBICIN, LINEZOLID, METRONIDAZOLE, RITUXIMAB, VINDESINE reactions: Drug ineffective, Respiratory failure serious: 1 patientsex: 2 drugs: AZITHROMYCIN ANHYDROUS, HYDROXYCHLOROQUINE reactions: Dyspnoea, Pulmonary embolism, Pulmonary venous thrombosis serious: 1 patientsex: 2 drugs: DEXAMETHASONE, ETOPOSIDE reactions: Acute kidney injury, Haemophagocytic lymphohistiocytosis, Hepatic failure, Rhabdomyolysis serious: 1 patientsex: 2 drugs: LEVOTHYROXINE, METFORMIN HYDROCHLORIDE reactions: Acute kidney injury, Anuria, Metabolic acidosis, Toxicity to various agents serious: 1 patientsex: 2 drugs: ASPIRIN, CLOPIDOGREL BISULFATE, ENOXAPARIN, TENECTEPLASE reactions: Spinal epidural haematoma serious: 1 patientsex: 2 drugs: FLUOROURACIL, LEUCOVORIN, OXALIPLATIN reactions: Hyponatraemia, Nausea, Paraneoplastic syndrome serious: 1 patientsex: 2 drugs: BEPOTASTINE BESILATE reactions: Drug hypersensitivity, Urticaria serious: 1 patientsex: 2 drugs: DOXORUBICIN, IFOSFAMIDE, TRABECTEDIN reactions: Haematotoxicity, Malignant neoplasm progression serious: 1 patientsex: 1 drugs: ASPIRIN, CLOPIDOGREL BISULFATE reactions: Cardiogenic shock, Chest haematoma, Mediastinal haemorrhage serious: 1 patientsex: 2 drugs: SITAGLIPTIN PHOSPHATE reactions: Diabetic ketoacidosis, Diabetic ketoacidosis serious: 1 patientsex: 2 drugs: BETAMETHASONE, HEPARIN SODIUM, GEMFILZIL reactions: Drug ineffective, Exposure during pregnancy serious: 1 patientsex: 2 drugs: MYTHILLERIDONE reactions: Aeruginosa infection, Brain abscess, Nocardiosis serious: 1 patientsex: 1 drugs: AZATHIOPRINE, MESALAMINE, PREDNISOLONE reactions: Diffuse large B-cell lymphoma, Intestinal abscess, Necrotising proctitis, Perirectal abscess, Sepsis serious: 1 patientsex: 1 drugs: BUSULFAN, FLUDARABINE PHOSPHATE, METHYLPREDNISOLONE reactions: Febrile neutropenia serious: 1 patientsex: 2 drugs: DARUNAVIR, RALTEGRAVIR, RITONAVIR reactions: Toxic encephalitis serious: 1 patientsex: 2 drugs: METFORMIN HYDROCHLORIDE, PREDNISOLONE reactions: Thrombotic thrombocytopenia serious: 1 patientsex: 1 drugs: ACETAMINOPHENHYDROCODONE, GABAPENTIN, HYDROCODONE BITARTRATE reactions: Aggression, Depression, Drug ineffective, Intentional overdose, Suicide attempt serious: 1 patientsex: 2 drugs: AMISULPRIDE, HYDROXYZINE HYDROCHLORIDE, PROTHIPENDYL, TRAZODONE HYDROCHLORIDE, ZOLPIDEM TARTRATE reactions: Haemorrhage intracranial, Product use in unapproved indication serious: 1 patientsex: 2 drugs: ACYCLOVIR, CARBOPLATIN, DEXAMETHASONE, ETOPOSIDE, IFOSFAMIDE, METHOTREXATE, PREDNISOLONE reactions: Disease recurrence, Visual acuity reduced serious: 1 patientsex: 2 drugs: METFORMIN HYDROCHLORIDE reactions: Anxiety, Hypotension, Lactic acidosis, Suicide attempt, Toxicity to various agents serious: 1 patientsex: 2 drugs: CYCLOPHOSPHAMIDE, DOXORUBICIN, PREDNISOLONE, VINCRISTINE reactions: Acute kidney injury, Haematotoxicity serious: 1 patientsex: 2 drugs: ALFACALCIDOL, CINACALCET HYDROCHLORIDE reactions: Hypercalcaemia, Hyperphosphataemia serious: 1 patientsex: 2 drugs: EVEROLIMUS, METHYLPREDNISOLONE, SIROLIMUS reactions: Acute fibrinous and organizing pneumonia serious: 1 patientsex: 1 drugs: HYDROCORTISONE reactions: Coma, Hypoglycaemia, Hypovolaemic shock, Hypoxia, Toxic encephalopathy serious: 1 patientsex: 2 drugs: PACLITAXEL reactions: Peripheral sensory neuropathy serious: 1 patientsex: 2 drugs: CYCLOPHOSPHAMIDE, DOXORUBICIN, ETOPOSIDE, METHYLPREDNISOLONE, PREDNISONE, RITUXIMAB, VINCRISTINE reactions: Atrioventricular block complete, Dizziness, Dyspnoea, Electrocardiogram QRS complex abnormal, Electrocardiogram tachycardia, Lymphopenia, Neutrophilia, Sinus bradycardia, Syncope serious: 2 patientsex: 2 drugs: CLONAZEPAM, LEVETIRACETAM, SODIUM OXYBATE, TOPIRAMATE reactions: Drug ineffective serious: 1 patientsex: 2 drugs: ALEMTUZUMAB, GLATIRAMER ACETATE, NATALIZUMAB reactions: Neutropenia serious: 1 patientsex: 1 drugs: DOCETAXEL, GEMCITABINE reactions: Disease progression serious: 1 patientsex: 2 drugs: CYCLOPHOSPHAMIDE, DOXORUBICIN HYDROCHLORIDE, PREDNISOLONE, TRASTUZUMAB reactions: Maternal exposure during pregnancy, Premature delivery, Septic shock serious: 1 patientsex: 2 drugs: AZITHROMYCIN ANHYDROUS reactions: Acute respiratory failure, Anaemia, Arrhythmia, Cardiac arrest, Thrombocytopenia serious: 1 patientsex: 2 drugs: DESFLURANE, GLYCOPYRROLATE, PENTOTHAL SODIUM, REMIFENTANIL, ROCURONIUM BROMIDE reactions: Wernickes encephalopathy serious: 1 patientsex: 2 drugs: MITOMYCIN reactions: Pterygium recurrence serious: 1 patientsex: 2 drugs: ARIPIPRAZOLE, OLANZAPINE, QUETIAPINE, SERTRALINE HYDROCHLORIDE reactions: Drug ineffective, Insomnia, Hallucination, auditory, auditory hallucination, auditory, auditory auditory, auditory auditory, auditory auditory, auditory auditory, auditory auditory, auditory auditory, auditory auditory, auditory auditory, auditory auditory, auditory auditory, auditory auditory, auditory auditory, auditory auditory, auditory auditory, auditory auditory, auditory auditory, auditory auditory, auditory auditory, auditory auditory, auditory auditory, auditory auditory, auditory auditory, auditory auditory, auditory auditory, auditory auditory, auditory auditory, auditory auditory, auditory auditory, auditory auditory, auditory auditory, auditory auditory, auditory auditory, auditory auditory, auditory auditory, auditory auditory, auditory auditory, auditory auditory, auditor serious: 1 patientsex: 1 drugs: CANDESARTAN, WARFARIN reactions: Hyponatraemia, Status epilepticus serious: 1 patientsex: 2 drugs: ASPIRIN, METHIMAZOLE reactions: Pancreatitis acute serious: 1 patientsex: 2 drugs: CAPECITABINE, LAPATINIB reactions: Arteriospasm coronary serious: 1 patientsex: 1 drugs: ACYCLOVIR, CIPROFLOXACIN, FLUCONAZOLE, HUMAN IMMUNOGLOBULIN G, SULFAMETHOXAZOLETRIMETHOPRIM reactions: Cytomegalovirus infection, Fungal infection, Pneumonia, Sepedonium infection serious: 1 patientsex: 1 drugs: NOREPINEPHRINE reactions: Cardiac arrest, Drug ineffective, Tumour lysis syndrome serious: 1 patientsex: 1 drugs: CYCLOPHOSPHAMIDE, CYTARABINE, DEXAMETHASONE, DOXORUBICIN, METHOTREXATE, PREDNISOLONE, RITUXIMAB, VINCRISTINE reactions: Drug ineffective, Respiratory distress serious: 1 patientsex: 2 drugs: NITROFURANTOIN reactions: Atypical pneumonic cystic hyperplasia, Pneumonia aspiration serious: 1 patientsex: 1 drugs: AZITHROMYCIN ANHYDROUS, CEFTAZIDIME, CLINDAMYCIN, HYDROXYCHLOROQUINE, RIBAVIRIN, OSELTAMIVIR, PREDNISOLONE reactions: Acute generalised exanthematous pustulosis serious: 1 patientsex: 2 drugs: FINGOLIMOD, YELLOW FEVER ANTIGEN reactions: Immune reconstitution inflammatory syndrome, Multiple sclerosis relapse serious: 1 patientsex: 2 drugs: FLUTICASONE PROPIONATESALMETEROL XINAFOATE, METHYLPREDNISOLONE reactions: Bacteraemia, Acute kidney injury serious: 1 patientsex: 2 drugs: AMLODIPINE BESYLATE, ASPIRIN, HYDROCHLOROTHIAZIDE, METFORMIN HYDROCHLORIDE, SIMVASTATIN reactions: Anaemia normochromic, Gastric hyperaemia, Eosinophilia, Gastrointestinal disorder, Helicobacter infection, Weight decreased serious: 1 patientsex: 1 drugs: EFAVIRENZ, LAMIVUDINE, NEVIRAPINE, STAVUDINE reactions: Pathogen resistance serious: 1 patientsex: 1 drugs: MITOMYCIN reactions: Conjunctival filtering bleb, Intraocular pressure increased, Ocular epithelial failure serious: 1 patientsex: 2 drugs: AFLIBERCEPT reactions: Choroidal neovascularisation, Macular hole serious: 1 patientsex: 1 drugs: AMOXICILLINCLAVULANATE POTASSIUM, SUCRALFATE SODIUM reactions: Odynophagia, Oesophageal ulcer serious: 1 patientsex: 2 drugs: MILRINOTECAN, MYCOPHENOLATE MOFETIL, PREDNISONE, TACROLIMUS reactions: Posterior reversible encephalopathy syndrome serious: 1 patientsex: 1 drugs: VANCOMYCIN reactions: Acute kidney injury serious: 1 patientsex: 1 drugs: ACYCLOVIR, PREDNISOLONE, QUINOLONE reactions: Drug-induced liver injury serious: 1 patientsex: 1 drugs: APIXABAN reactions: Arteriovenous malformation, Subdural haematoma serious: 1 patientsex: 1 drugs: VERAPAMIL HYDROCHLORIDE reactions: Cardiogenic shock, Hypotension, Overdose, Sinus arrest, Toxicity to various agents serious: 1 patientsex: 2 drugs: CARBOPLATIN, PACLITAXEL reactions: Teratoma serious: 1 patientsex: 1 drugs: CARBAMAZEPINE reactions: Intentional overdose, Toxicity to various agents serious: 1 patientsex: 1 drugs: CEFOPORAZONESULBACTAM, COLISTIN, HYDROCORTISONE, METHYLPREDNISOLONE reactions: Bartters syndrome serious: 1 patientsex: 1 drugs: BASILIXIMAB, EVEROLIMUS, PREDNISOLONE, TACROLIMUS reactions: Acute kidney injury, Kaposis sarcoma serious: 1 patientsex: 1 drugs: ADEFOVIR DIPIVOXIL reactions: Fanconi syndrome acquired, Nephropathy serious: 1 patientsex: 1 drugs: LEVOFLOXACIN, FURAZOLIDINE, RABEPRAZOLE reactions: Toxic epidermal necrolysis serious: 1 patientsex: 1 drugs: ASPIRIN, CLOPIDOGREL BISULFATE, TIROFIBAN reactions: Drug ineffective, Drug resistance serious: 1 patientsex: 2 drugs: BACLOFEN reactions: Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation serious: 1 patientsex: 2 drugs: DEXAMETHASONE reactions: Adrenal hyperplasia, Cushings syndrome, Ectopic adrenal hormone secretion, Hypokalaemia, Off label use, Product use in unapproved indication, Weight decreased serious: 1 patientsex: 2 drugs: PEGINTERFERON ALFA-2A, RIBAVIRIN, SOFOSBUVIR reactions: Anaemia, Gluteus abscess, Leukopenia, Lymphadenopathy, Lymph node tuberculosis, Night sweats, Pyrexia, Tuberculosis serious: 1 patientsex: 2 drugs: ATOOSIBAN, MORPHINE, OXYCODONE HYDROCHLORIDE, NEFOPAM reactions: Foetal exposure during pregnancy, Megacystis jirovecii pneumonia, Off label use, Product use in unapproved indication serious: 1 patientsex: 1 drugs: AMIODARONE, EPINEPHRINE, MAGNESIUM, LIDOCAINE, SODIUM CHLORIDE reactions: Drug ineffective, Ventricular fibrillation serious: 1 patientsex: 1 drugs: FENOFIBRATE, FLUNITRAZEPAM, LAMIVUDINE, LEVOMEPROMAZINE, SERTRALINE HYDROCHLORIDE, QUAZEPAM, RALTEGRAVIR, ZIDOVUDINE reactions: Diabetes mellitus serious: 1 patientsex: 2 drugs: BUDESONIDE, DACLIZUMAB, MERCAPTOPURINE, PREDNISOLONE reactions: Febrile neutropenia serious: 1 patientsex: 1 drugs: CAPECITABINE, PHENYTOIN reactions: Drug interaction, Drug level increased, Toxicity to various agents serious: 1 patientsex: 2 drugs: FOLIC ACID, METHOTREXATE, TOFACITINIB CITRATE reactions: Herpes zoster serious: 1 patientsex: 2 drugs: AZITHROMYCIN ANHYDROUS, LINEZOLID, TOBRAMYCIN reactions: Gastrointestinal disorder serious: 1 patientsex: 1 drugs: SORAFENIB reactions: Hepatic enzyme increased serious: 1 patientsex: 1 drugs: CYTARABINE, FLUDARABINE PHOSPHATE, IDARUBICIN reactions: Bacterial infection, Febrile neutropenia, Pseudomonas infection, Sepsis serious: 1 patientsex: 1 drugs: ACYCLOVIR, BUSULFAN, CYCLOSPORINE, FLUDARABINE PHOSPHATE, METHOTREXATE, THIOTEPA, VALGANCICLOVIR reactions: Cytomegalovirus chorioretinitis, Cytomegalovirus infection, Cytomegalovirus vasculitis, Cytomegalovirus infection reactivation, Retinal haemorrhage, Retinal vasculitis, Retinal necrosis, Retinal haemorrhage, Retinal vasculitis, Retinal necrosis, Retinal haemorrhage, Retinal necrosis, Retinal haemorrhage, Retinal necrosis, Retinal haemorrhage, Retinal necrosis, Retinal haemorrhage, Retinal necrosis, Retinal haemorrhage, Retinal necrosis, Retinal haemorrhage, Ret serious: 1 patientsex: 2 drugs: BISOPROLOL, FLECAINIDE, HYDROXYZINE HYDROCHLORIDE, LORATADINE reactions: Torsade de pointes, Ventricular fibrillation serious: 1 patientsex: 1 drugs: CLOZAPINE, OLANZAPINE, QUETIAPINE, RISPERIDONE reactions: Electrocardiogram QT prolonged serious: 1 patientsex: 2 drugs: DOCETAXEL, PERTUZUMAB, TRASTUZUMAB reactions: Charcot-Marie-Tooth syndrome serious: 1 patientsex: 2 drugs: FOLATE SODIUM, VALPROIC ACID reactions: Foetal anticonvulsant syndrome, Polyhydramnios serious: 1 patientsex: 2 drugs: BISOPROLOL, FUROSEMIDE, SPIRONOLACTONE reactions: Ischaemic stroke serious: 1 patientsex: 1 drugs: CLOZAPINE, LITHIUM, OLANZAPINE, VALPROIC ACID reactions: Pancreatitis acute serious: 1 patientsex: 1 drugs: BORTEZOMIB, DEXAMETHASONE, IXAZOMIB, LENALIDOMIDE, ZOLEDRONIC ACID reactions: Cutaneous necrotising vasculitis serious: 1 patientsex: 2 drugs: DEXAMETHASONE, MYCOPHENOLATE MOFETIL, TACROLIMUS reactions: Cytomegalovirus colitis, Retinitis serious: 1 patientsex: 2 drugs: DOCETAXEL, PERTUZUMAB, TRASTUZUMAB reactions: Malignant neoplasm, Metastases to liver, Metastases to lung serious: 1 patientsex: 1 drugs: IMATINIB MESYLATE reactions: Pancytopenia serious: 1 patientsex: 2 drugs: LEVONORGESTREL reactions: Device dislocation serious: 1 patientsex: 1 drugs: ASPIRIN, ATORVASTATIN, BUSPIRONE HYDROCHLORIDE, CLOPIDOGREL BISULFATE, METOPROLOL SUCCINATE, THIAMINE reactions: Angioedema serious: 1 patientsex: 2 drugs: METHOTREXATE, PREDNISONE reactions: Chorioretinitis, Condition aggravated, Retinal detachment, Visual acuity reduced serious: 1 patientsex: 1 drugs: AMISULPRIDE, BIPERIDEN, LORAZEPAM, PROPRANOLOL HYDROCHLORIDE, RISPERIDONE reactions: Akathisia, Drug withdrawal syndrome, Dystonia, Pneumonia aspiration serious: 1 patientsex: 1 drugs: RIVAROXABAN reactions: Cardiac failure, Constrictive pericarditis serious: 1 patientsex: 2 drugs: TOPOTECAN HYDROCHLORIDE reactions: Meningitis serious: 1 patientsex: 2 drugs: BORTEZOMIB, DEXAMETHASONE, LENALIDOMIDE reactions: Acute kidney injury, Cardiac arrest, Chronic kidney disease, Shock, Thrombotic microangiopathy serious: 1 patientsex: 1 drugs: BENDAMUSTINE, BRENTUXIMAB VEDOTIN reactions: Acute kidney injury serious: 1 patientsex: 1 drugs: ALENDRONATE SODIUM, CALCITRIOL, CALCIUM, CALCIUM CHLORIDE, CALCIUM SULFATE, CALCIUM CARBONATE, CALCIUM PHOSPHATE, CALCIUM CARBONATEVITAMIN D NOS reactions: Blood parathyroid hormone increased, Hypocalcaemia serious: 1 patientsex: 2 drugs: TEMOZOLOMIDE reactions: Central nervous system neurocytoma serious: 1 patientsex: 1 drugs: CYCLOPHOSPHAMIDE, METHYLPREDNISOLONE, TACROLIMUS reactions: Drug ineffective, Nocardiosis serious: 1 patientsex: 2 drugs: FLUOXETINE HYDROCHLORIDE reactions: Anxiety, OCD, auditory hallucination, Suicidal ideation serious: 1 patientsex: 2 drugs: TEMOZOLOMIDE reactions: Maternal exposure during pregnancy serious: 1 patientsex: 1 drugs: PEMBROLIZUMAB reactions: Arthritis, Fasciitis, Immune-mediated adverse reaction serious: 1 patientsex: 2 drugs: ACYCLOVIR, CEFEPIME HYDROCHLORIDE, LEVOFLOXACIN, MAGNESIUM FUNGIN, POSACONAZOLE, PENTAMIDINE reactions: Cellulosimicrobium infection, Pneumonia serious: 1 patientsex: 1 drugs: DOCETAXEL, PREDNISONE reactions: Death, Toxicity to various agents serious: 1 patientsex: 2 drugs: ARSENIC TRIOXIDE reactions: Bone marrow fibrosis serious: 1 patientsex: 1 drugs: ADALIMUMAB, INFLIXIMAB reactions: Crohns disease serious: 1 patientsex: 2 drugs: CINACALCET HYDROCHLORIDE reactions: Drug intolerance, Hypercalcaemia, Nausea, Vomiting serious: 1 patientsex: 1 drugs: ACETAMINOPHEN reactions: Acute kidney injury, Hepatic necrosis, Hepatic toxicity, Overdose, Toxicity to various agents serious: 1 patientsex: 2 drugs: ATORVASTATIN, LISINOPRIL reactions: Drug ineffective, Hepatic fibrosis, Hepatic steatosis serious: 1 patientsex: 2 drugs: BUSULFAN, CYCLOPHOSPHAMIDE, CYCLOSPORINE, MYCOPHENOLATE MOFETIL, PREDNISONE reactions: Acute graft versus host disease, Nausea, Pericardial effusion, Pneumonia, Vomiting serious: 1 patientsex: 2 drugs: HYDROXYCHLOROQUINE reactions: COVID-19 serious: 1 patientsex: 1 drugs: CYTARABINE, FLUDARABINE PHOSPHATE, IDARUBICIN, HYDROXYUREA, FLUDARABINE PHOSPHATE, IMATINIB, PIPERACILLIN SODIUMTAZOBACTAM SODIUM, VORICONAZOLE reactions: Bronchopulmonary aspergillosis, Bronchopulmonary aspergillosis, Bronchopulmonary aspergillosis, Bronchopulmonary aspergillosis, Bronchopulmonary aspergillosis, Bronchopulmonary aspergillosis, Bronchopulmonary aspergillosis, Bronchopulmonary aspergillosis, Bronchopulmonary aspergillosis, Bronchopulmonary aspergillosis, Bronchopulmonary aspergillosis, Bronchopulmonary aspergillosis, Bronchopulmonary aspergillosis, Bronchopulmonary aspergillosis, Bronchopulmonary aspergillosis, Broncho serious: 1 patientsex: 1 drugs: CARBOPLATIN, CISPLATIN, GEMCITABINE, PACLITAXEL reactions: Drug ineffective serious: 1 patientsex: 2 drugs: ATORVASTATIN, CAPECITABINE, TEMOZOLOMIDE, TORIPALIMAB reactions: Drug resistance, Genotype drug resistance test positive serious: 1 patientsex: 1 drugs: METHYLPREDNISOLONE reactions: Autoimmune hepatitis serious: 1 patientsex: 2 drugs: DOXORUBICIN HYDROCHLORIDE, ETHIODIZED OIL reactions: Cerebral embolism serious: 1 patientsex: 1 drugs: CYCLOPHOSPHAMIDE, FLUDARABINE PHOSPHATE, METHOTREXATE, TACROLIMUS reactions: Graft versus host disease, Infection, Off label use, Product use in unapproved indication serious: 1 patientsex: 1 drugs: HUMAN IMMUNOGLOBULIN G reactions: Tubulointerstitial nephritis serious: 1 patientsex: 2 drugs: CELECOXIB, DULOXETINE, ESOMEPRAZOLE MAGNESIUM, METHADONE HYDROCHLORIDE, OXYCODONE, PREGABALIN reactions: Serotonin syndrome serious: 1 patientsex: 1 drugs: ENOXAPARIN reactions: Drug-induced liver injury serious: 1 patientsex: 2 drugs: ALEDRONIC ACID reactions: Osteonecrosis of jaw serious: 1 patientsex: 2 drugs: AMITRIPTYLINE, CODEINE, FLUCLOXACILLIN, METRONIDAZOLE, PHENOXYMETHYLPENICIN reactions: Abdominal pain, Abdominal discomfort, Irritable bowel syndrome, Intestinal infection, Off label use, Product use in unapproved indication serious: 1 patientsex: 1 drugs: CYCLOSPORINE reactions: Drug ineffective serious: 1 patientsex: 2 drugs: LOSARTAN, NITROFURANTOIN, TROPPIUM CHLORIDE reactions: Organising pneumonia serious: 1 patientsex: 1 drugs: CASPOFUNGIN ACETATE, CILASTATIN SODIUM, IMIPENEM, METHIMAZOLE, VANCOMYCIN reactions: Aspergillus infection, Cough, Cough is aggravated, Cough is recurrent, Cough is aggravated, Cough is recurrent, Cough is aggravated, Cough is recurrent, Cough is recurrent, Cough is recurrent, Cough is recurrent, Cough is recurrent, Cough is recurrent, Cough is recurrent, Cough is recurrent, Cough is recurrent, Cough is recurrent, Cough is recurrent, Cough is recurrent, Cough is recurrent, Cough is recurrent, Cough is recurrent, Cough is recurrent, Cough is recurrent, Cough is recurrent, Cough is recurrent, Cough is recurrent, Cough is recurrent, Cough is recurrent, Cough is recurrent serious: 1 patientsex: 2 drugs: ERYTHROMYCIN, GEMCITABINEGEMCITABINE HYDROCHLORIDE, METOCLOPRAMIDE, OMEPRAZOLE, QUININE SULFATE, ZOPICLONE reactions: Chest infection, Diarrhoea, Fatigue, Phlebitis, Sore mouth serious: 1 patientsex: 1 drugs: ACETAMINOPHEN, CETIRIZINE HYDROCHLORIDE, DEXAMETHASONE, PANTOPRAZOLE SODIUM, THALIDOMIDE reactions: Acute kidney injury, Acute respiratory distress syndrome, Anaemia, Acute kidney injury, Acute kidney injury, Anaemia, Leukocytosis, Thrombocytopenia, Toxic epidermal necrolysis serious: 1 patientsex: 1 drugs: ACETAMINOPHEN, CYCLOPHOSPHAMIDE, DOXORUBICIN, DOXORUBICIN HYDROCHLORIDE, DOXORUBICIN HYDROCHLORIDE, DOXORUBICIN HYDROCHLORIDE, DOXORUBICIN HYDROCHLORIDE, DOXORUBICIN HYDROCHLORIDE, DOXORUBICIN HYDROCHLORIDE, DOXORUBICIN HYDROCHLORIDE, DOXORUBICIN HYDROCHLORIDE, FOSPHENYTOIN, LEVETIRACETAM, METHOTREXATE, VINCRISTINE reactions: Cerebral infarction, Drug ineffective serious: 1 patientsex: 1 drugs: GLYCOPYRROLATE, OXYGEN, SEVOFLURANE, THIOPENTAIL reactions: Cyanosis, Dyspnoea, Lip oedema, Post procedural croup, Stridor serious: 1 patientsex: 1 drugs: HEPARIN SODIUM, LIMACPROST, PRAVASTATIN, WARFARIN reactions: Cholestasis, Drug ineffective, Renal failure serious: 1 patientsex: 2 drugs: CYCLOPHOSPHAMIDE, PREDNISONE, RITUXIMAB reactions: Aspergillus infection, Thrombotic microangiopathy serious: 1 patientsex: 1 drugs: CARBOPLATIN, ETOPOSIDE, PEGLASTA reactions: Bradycardia serious: 1 patientsex: 2 drugs: GLANTAMINE, MEMANTIN, SURVEXANT reactions: Parkinsonism, Pleurothotonus serious: 1 patientsex: 2 drugs: AZATHIOPRINE, HYDROXYCHLOROQUINE, PREDNISOLONE reactions: Arthritis, Escherichia infection, Meningitis bacterial, Sacroiliitis serious: 1 patientsex: 2 drugs: BUPIVACAINE, FENTANYL, KETAMINE, MIDAZOLAM HYDROCHLORIDE, HYALURONDASE, XYLOCAINE reactions: Blood glucose increased, Drug ineffective, Hypotension, Sedation serious: 1 patientsex: 1 drugs: METHIMAZOLE reactions: Lupus-like syndrome, Immunoglobulin A deficiency serious: 1 patientsex: 1 drugs: ASPIRIN, CLOPIDOGREL BISULFATE, ELTROMBOPAG, PRASUGREL HYDROCHLORIDE, UROKINASE, ZOTARIUM reactions: Acute coronary syndrome, Coronary artery stenosis, Coronary artery thrombosis serious: 1 patientsex: 1 drugs: CALCIUM CARBONATE, CYCLOSPORINE, FUROSEMIDE, LANSOPRAZOLE, HEPARIN SODIUM, MIZORIBINE, PREDNISOLONE, WARFARIN reactions: Calciphylaxis, Drug ineffective, Psuedomonas infection serious: 1 patientsex: 2 drugs: HUMIRA, PREDNISONE reactions: Mycobacterium avium complex infection serious: 1 patientsex: 1 drugs: METHYLPREDNISOLONE, PREDNISOLONE reactions: Neuro-Sweet disease serious: 1 patientsex: 2 drugs: CARBAMAZEPINE, CLONAZEPAM, HALOPERIDOL, IMIPRAMINE, PAROXETINE, PALIPERIDONE reactions: Drug ineffective serious: 1 patientsex: 1 drugs: MIRTAZAPINE reactions: Sedation serious: 1 patientsex: 1 drugs: OLANZAPINE reactions: Major depression, Treatment noncompliance serious: 1 patientsex: 1 drugs: ALFUZOSIN, FINASTERIDE, GABAPENTIN, INSULIN NOS, METFORMIN HYDROCHLORIDE, MYCOPHENOLIC ACID, PREDNISONE, RANIBIZUMAB, VILDAGLIPTIN reactions: Alveolar proteinosis, Cough, Dyspnoea exertional, Pulmonary alveolar proteinosis, Weight decreased serious: 1 patientsex: 1 drugs: ABIRATERONE ACETATE, BICALUTAMIDE, LEUPROLIDE ACETATE, ZOLEDRONIC ACID reactions: Anaemia, Fatigue, Nail disorder, Thrombocytopenia serious: 1 patientsex: 2 drugs: FLUOROURACIL, LEUCOVORIN, OXALIPLATIN reactions: Posterior reversible encephalopathy syndrome serious: 1 patientsex: 1 drugs: TACROLIMUS reactions: Central nervous system lymphoma serious: 1 patientsex: 2 drugs: CISPLATIN, PACLITAXEL reactions: Febrile neutropenia serious: 1 patientsex: 1 drugs: CYCLOSPORINE, FLUTICASONE PROPIONATESALMETEROL XINAFOATE, OMALIZUMAB, MOMETASONE FUROATE HYDROCHLORIDE, PREDNISOLONE, SALMETEROL XINAFOATE reactions: Anaemia, Bone marrow failure, Cytopenia, Dysplasia, Hypoplastic marrow, Pancytopenia, Respiratory disorder serious: 1 patientsex: 1 drugs: ASPIRIN, WARFARIN reactions: Haemolytic anaemia, Heparin-induced thrombocytopenia serious: 1 patientsex: 1 drugs: ATENOLOL, DULOXETINE HYDROCHLORIDE, METFORMIN HYDROCHLORIDE reactions: Lichenoid keratosis serious: 1 patientsex: 1 drugs: BETAMETHASONE, CELESTRETE, METHYLDOPA, PRAZOSIN reactions: Exposure during pregnancy, Premature rupture of oesophageal wall serious: 1 patientsex: 1 drugs: ALPRAZOLAM, CLOMIPRAMINE, MIRTAZAPINE, RISPERIDONE, VENLAFAXINE HYDROCHLORIDE reactions: Neuroleptic malignant syndrome, Serotonin syndrome serious: 1 patientsex: 1 drugs: CISPLATIN, CYCLOPHOSPHAMIDE, DOXORUBICIN, PREDNISOLONE, VINCRISTINE reactions: Haematotoxicity serious: 1 patientsex: 2 drugs: ETHINYL ESTRADIOLDROSPIRENONE reactions: Abortion spontaneous, Deep vein thrombosis serious: 1 patientsex: 2 drugs: ANASTROZOLE, CARBOPLATIN, PEMETREXED reactions: Disease progression, Metastases to lymph nodes, Respiratory failure serious: 1 patientsex: 1 drugs: AMPICILLIN, CYCLOPHOSPHAMIDE, DEXAMETHASONE, HYDROXYCHLOROQUINE, VANCOMYCIN reactions: Drug ineffective serious: 1 patientsex: 1 drugs: BLEOMYCIN SULFATE, DACARBAZINE, DOXORUBICIN, FILGRASTIM, VINBLASTINE reactions: Hodgkins disease recurrent serious: 1 patientsex: 2 drugs: QUETIAPINE, VALPROIC ACID reactions: Hypothyroidism, Ileus paralytic serious: 1 patientsex: 2 drugs: ADALIMUMAB, ETHAMBUTOL HYDROCHLORIDE, ISONIAZID, LEVOFLOXACIN, METHYLPREDNISOLONE, PYRAZINAMIDE, RIFAMPIN reactions: Immune reconstitution inflammatory syndrome, Upper gastrointestinal haemorrhage serious: 1 patientsex: 1 drugs: ACETAMINOPHENHYDROCODONE, CITALOPRAM HYDROBROMIDE, FOLIC ACID, INFLIXIMAB, NAPROXEN, TRAMADOL reactions: Eosinophilic fasciitis, Urticaria serious: 1 patientsex: 2 drugs: ALBUTEROL, DEXAMETHASONE, SODIUM CHLORIDE reactions: Hypotension, Lactic acidosis serious: 1 patientsex: 2 drugs: DACTINOMYCIN, LEUCOVORIN, METHOTREXATE reactions: Drug ineffective, Drug resistance, Neoplasm recurrence serious: 1 patientsex: 2 drugs: EZETIMIBE, ROSUVASTATIN reactions: Drug ineffective serious: 1 patientsex: 2 drugs: LEVOFLOXACIN, RAMIPRIL, SIMVASTATIN reactions: Delirium serious: 1 patientsex: 1 drugs: DAPTOMYCIN, MEROPENEM, MOXIFLOXACIN, TACROLIMUS reactions: Abdominal pain, Diarrhoea, Drug level above therapeutic, Enterococcal infection, Fungaemia, Nausea, Pyrexia, Renal impairment serious: 1 patientsex: 2 drugs: CAPECITABINE, EVEROLIMUS, TEMOZOLOMIDE reactions: Disease progression serious: 1 patientsex: 2 drugs: PROTAMINE SULFATE reactions: Acute pulmonary hypertension, Acute kidney injury, Right ventricular failure, Pulmonary hypertension serious: 1 patientsex: 1 drugs: AMLODIPINE BESYLATE, ASPIRIN, LANSOPRAZOLE, LOSARTAN, WARFARIN reactions: Oesophageal haematoma serious: 1 patientsex: 2 drugs: HUMAN IMMUNOGLOBULIN G reactions: Exposure during pregnancy, Haemolytic anaemia serious: 1 patientsex: 1 drugs: CAPTOPRIL, HYDROXYCHLOROQUINE, METFORMIN HYDROCHLORIDE reactions: COVID-19, Multiple organ dysfunction syndrome, Respiratory disorder serious: 1 patientsex: 1 drugs: CYCLOPHOSPHAMIDE, CYTARABINE, DEXAMETHASONE, LENALIDOMIDE, METHOTREXATE reactions: Acute lymphocytic leukaemia, Gene mutation, Gastrointestinal toxicity serious: 1 patientsex: 2 drugs: DOCETAXEL reactions: Generalised tonic-clonic seizure serious: 1 patientsex: 2 drugs: METHENAMINE HYDROCHLORIDE, NITROFURANTOIN reactions: Urinary tract infection bacterial serious: 1 patientsex: 1 drugs: BUDESONIDE, METHYLPREDNISOLONE, MESALAMINE, PANTOPRAZOLE SODIUM reactions: Anaemia, Drug ineffective, Haemorrhage serious: 1 patientsex: 2 drugs: AMOXICILLINCLAVULANIC ACID, FENTANYL, ISOFLURANE, MAGNESIUM SULFATE, NITROUS OXIDE, PROPOFOL, VECURONIUM BROMIDE reactions: Drug interaction, Exposure during pregnancy, Neuromuscular block prolonged serious: 1 patientsex: 2 drugs: PREDNISOLONE reactions: Dysphagia, Paraplegia, Visual impairment serious: 1 patientsex: 1 drugs: BICALUTAMIDE, DEGARELIX reactions: Hot flush, Erectile dysfunction, Libido decreased, Sexual dysfunction serious: 1 patientsex: 1 drugs: DAPTOMYCIN, GENTAMICIN, RIFAMPIN, VANCOMYCIN reactions: Drug ineffective serious: 1 patientsex: 1 drugs: ARIPIPRAZOLE, CLOMIPRINE, INSULIN NOS, METFORMIN HYDROCHLORIDE, NIFEDIPINE, VENLAFAXINE HYDROCHLORIDE reactions: Tubulointerstitial nephritis serious: 1 patientsex: 2 drugs: CYCLOPHOSPHAMIDE, DOXORUBICIN, PREDNISONE, RITUXIMAB, VINCRISTINE reactions: Drug ineffective serious: 2 patientsex: 2 drugs: VERAPAMIL HYDROCHLORIDE reactions: Off label use serious: 1 patientsex: 2 drugs: GONADANTROPIN, METHYLPREDNISOLONE reactions: Abortion spontaneous, Exposure during pregnancy serious: 1 patientsex: 2 drugs: HUMAN IMMUNOGLOBULIN G, METHOTREXATE, PREDNISONE reactions: Eczema, Off label use serious: 1 patientsex: 2 drugs: BOSUTINIB, DASATINIB, IMATINIB MESYLATE reactions: Diarrhoea, Drug ineffective, Rash serious: 1 patientsex: 2 drugs: BUSULFAN, CYCLOPHOSPHAMIDE, DOXORUBICIN, IFOSFAMIDE, MELPHALAN, VINCRISTINE reactions: Drug ineffective, Meningeal disorder, Pericardial effusion serious: 1 patientsex: 1 drugs: EPINEPHRINE, HYDROXYETHYLENE SODIUM, INSULIN NOS, POTASSIUM CHLORIDE, SODIUM BICARBONATE reactions: Osmotic demyelination syndrome, Type 1 diabetes mellitus serious: 1 patientsex: 1 drugs: ALBUTEROL, AMINOPHYLLINE, ALBUTEROL SUCCINATE, MAGNESIUM SULFATE, METHYLPREDNISOLONE, IPRATROPIUM BROMIDE reactions: Hypotension, Status asthmaticus serious: 1 patientsex: 1 drugs: ACYCLOVIR, CYCLOPHOSPHAMIDE, FLUDARABINE PHOSPHATE, RITUXIMAB reactions: Adenovirus infection, Multiple organ dysfunction syndrome, Pancytopenia serious: 1 patientsex: 1 drugs: DENOSUMAB, FELVESTRAN, LEUPROLIDE ACETATE reactions: Diarrhoea, Fatigue, Neutropenia, Thrombocytopenia serious: 1 patientsex: 1 drugs: ETHAMBUTOL HYDROCHLORIDE, ISONIAZID, LEVOFLOXACIN, PYRAZINAMIDE, RIFAMPIN reactions: Ocular toxicity serious: 1 patientsex: 2 drugs: CISPLATIN, FLUOROURACIL reactions: Bladder perforation serious: 1 patientsex: 2 drugs: FLUOROURACIL, LEUCOVORIN, OXALIPLATIN reactions: Neuropathy peripheral serious: 1 patientsex: 2 drugs: ETOPOSIDE reactions: Renal failure serious: 1 patientsex: 2 drugs: HEPARIN SODIUM, WARFARIN reactions: Drug ineffective, Exposure during pregnancy, Therapeutic response decreased serious: 1 patientsex: 1 drugs: EPOPROSTENOL, FUROSEMIDE, PROSTACYCLINE reactions: Pulmonary oedema serious: 1 patientsex: 2 drugs: LENVATINIB reactions: Cerebral artery dissection serious: 1 patientsex: 2 drugs: CHLORPHENIRAMINE, LEVOCETIRIZINE, PREDNISOLONE reactions: Anaphylactic reaction serious: 1 patientsex: 2 drugs: BUPIVACAINE, COMPAZINE, TORADOL reactions: Encephalitis viral, Renal failure, Varicella zoster virus infection serious: 1 patientsex: 1 drugs: HYDROMORPHONE reactions: Acute kidney injury, Hypertension, Posterior reversible encephalopathy syndrome serious: 1 patientsex: 1 drugs: DOBUTAMINEDOBUTAMINE HYDROCHLORIDE, LIDOCAINE, MILRINONE, MAGNESIUM, TACROLIMUS reactions: Hypomagnesaemia, Ventricular tachycardia serious: 1 patientsex: 1 drugs: CRIZOTONIB reactions: Gangrene, Neurological decompensation, Off label use, Product use in unapproved indication serious: 1 patientsex: 2 drugs: LETROZOLE reactions: Hypercalcaemia serious: 1 patientsex: 2 drugs: MYCOPHENOLIC ACID, PREDNISONE, TACROLIMUS reactions: Calcineuria, Haematuria, Parathyroid hormone increased, Stress fracture serious: 1 patientsex: 1 drugs: FENTANYL reactions: Laryngospasm serious: 1 patientsex: 2 drugs: ASPIRIN, CYCLOSPORINE, METHYLPREDNISOLONE, PREDNISOLONE, RITUXIMAB, VITAMINS reactions: Diabetic ketoacidosis, Diabetes insipidus, Hypothyroidism, Insulin-dependent diabetes mellitus, Weight increased serious: 1 patientsex: 1 drugs: ATEZOLIZUMAB reactions: Meningitis aseptic serious: 1 patientsex: 2 drugs: CARBOPLATIN, PACLITAXEL reactions: Hypersensitivity, Neuropathy peripheral serious: 1 patientsex: 2 drugs: VALPROIC ACID reactions: Acute hepatic failure, Encephalopathy, Mitochondrial toxicity serious: 1 patientsex: 2 drugs: BUPIVACAINE, FENTANYL, MIDAZOLAM HYDROCHLORIDE, PROPOFOL, TRANEXAMIC ACID reactions: Accidental exposure to product, Apnoea, Drug ineffective, Hypertension, Metabolic acidosis, Myoclonus, Myoclonus serious: 1 patientsex: 2 drugs: FUROSEMIDE, MAGNESIUM SULFATE reactions: Hyperkalaemia, Hypocalcaemia serious: 1 patientsex: 1 drugs: CISPLATIN, FLUCONAZOLE reactions: Treatment failure serious: 1 patientsex: 1 drugs: AMOXICILLINCLAVULANIC ACID, METHYLPREDNISOLONE, MYCOPHENOLATE MOFETIL, TACROLIMUS reactions: Acute coronary syndrome, Gastrointestinal haemorrhage, Hepatic function abnormal, Hepatitis E, Lower gastrointestinal haemorrhage serious: 1 patientsex: 2 drugs: ETHAMBUTOL HYDROCHLORIDE, ISONIAZID, PYRAZINAMIDE, RIFAMPIN reactions: Paradoxical drug reaction serious: 1 patientsex: 1 drugs: NITROGLYCERIN reactions: Acute myocardial infarction serious: 1 patientsex: 1 drugs: ABIRATERONE, DOCETAXEL reactions: Drug resistance serious: 1 patientsex: 2 drugs: BEVACIZUMAB, CISPLATIN, ETOPOSIDE reactions: Nausea, Neutropenia, Vomiting serious: 1 patientsex: 1 drugs: ALLOPURINOL, PERINDOPRIL, PROPRANOLOL HYDROCHLORIDE reactions: Aortic dissection, Pneumatosis intestinalis, Pneumoperitoneum serious: 1 patientsex: 2 drugs: BISOPROLOL, ENTECAVIR, FUROSEMIDE, LOVASTATIN, HYDROCORTISONE, SPIRONOLACTONE, VERAPAMIL HYDROCHLORIDE reactions: Adrenal insufficiency serious: 1 patientsex: 1 drugs: METHYLPREDNISOLONE, MYCOPHENOLATE MOFETIL, TACROLIMUS reactions: Catatonia serious: 1 patientsex: 2 drugs: FUROSEMIDE, RITUXIMAB, PREDNISOLONE reactions: Acute respiratory distress syndrome, Posterior reversible encephalopathy syndrome serious: 1 patientsex: 2 drugs: CARBOPLATIN, PACLITAXEL reactions: Cachexia, Neutropenia, Pancytopenia serious: 1 patientsex: 2 drugs: WARFARIN reactions: Anaemia, Haemothorax serious: 1 patientsex: 2 drugs: DOXORUBICIN, MITOMYCIN reactions: Neutrophil count decreased serious: 1 patientsex: 2 drugs: ACETAMINOPHEN, BUPIVACAINE, CEFAZOLIN, KETOPROFEN, NEFOPAM, POVIDONE-IODINE, SODIUM CHLORIDE reactions: Meningitis aseptic serious: 1 patientsex: 2 drugs: BORTEZOMIB, DEXAMETHASONE, DOXORUBICIN, METHYLPREDNISOLONE, ZOLEDRONIC ACID reactions: Constipation, Neuropathy peripheral, Lethargy serious: 1 patientsex: 2 drugs: BLEOMYCIN SULFATE, CYCLOPHOSPHAMIDE, DOXORUBICIN, METHOTREXATE, PREDNISONE, RITUXIMAB, VINCRISTINE reactions: Anaemia, Drug reaction with eosinophilia and systemic symptoms, Febrile neutropenia, Nausea, Oral mucosal inflammation, Thrombocytopenia serious: 1 patientsex: 1 drugs: VORICONAZOLE reactions: Cunninghamella infection, Neutropenia serious: 1 patientsex: 2 drugs: CARBIDOPAENTACAPONELEVODOPA, RASAGILINE MESYLATE reactions: Hypoglycaemia serious: 1 patientsex: 1 drugs: ERLOTINIB, METHOTREXATE reactions: Haemoptysis, Hepatic function abnormal, Metastases to liver, Myelosuppression, Product use in unapproved indication, Small cell lung cancer serious: 1 patientsex: 2 drugs: BEVACIZUMAB, CISPLATIN, DOCETAXEL, ETOPOSIDE, OXALIPLATIN reactions: Alopecia, Asthenia, Bone pain, Dyspnoea, Fatigue, Haemorrhage, Infection, Nausea, Neutropenia, Ovarian cancer, Ovarian toxicity, Pain, Pain in extremity, Pyrexia, Rash, Rash maculo-papular, Rash maculo-papular, Rash maculo-papular, Rash maculo-papular, Rash maculo-papular, Rash maculo-papular, Rash maculo-papular, Rash maculo-papular, Rash maculo-papular, Rash maculo-papular, Rash maculo-papular, Rash maculo-papular, Rash maculo-papular, Rash maculo-papular, Rash maculo-papular, Rash maculo-papular, Rash macul serious: 1 patientsex: 1 drugs: CALCIUM CARBONATE, CHOLECALCIFEROL, CYCLOSPORINE, IBANDRONATE SODIUM, MYCOPHENOLATE MOFETIL reactions: Aortic calcification, Back pain, Back pain, Chronic kidney disease, Drug ineffective, Drug interaction, Femoral neck fracture, Ibandronate, Ischaemic nephropathy, Joint fracture, Joint calcification, Joint fracture, Joint fracture, Joint fracture, Joint fracture, Joint fracture, Joint fracture, Joint fracture, Joint fracture, Joint fracture, Joint fracture, Joint fracture, Joint fracture, Joint fracture, Joint fracture, Joint fracture, Joint fracture, Joint fracture, Joint fracture, Joint fracture, Joint fracture, Joint fracture, Joint fracture, Joint fracture, Joint fracture, Joint fracture, Joint fracture, Joint fracture, Joint fracture, Joint fracture, Joint fracture, Joint fracture, Joint fracture, Joint fracture, Joint fracture, Joint fracture, Joint fracture, Joint fracture, Joint fracture, Joint fracture, Joint fracture, Joint fracture, Joint fracture, Joint fracture, Joint fracture, Joint fracture, Joint fracture, Joint fracture, Joint fracture, Joint fracture serious: 1 patientsex: 1 drugs: KETOCONAZOLE, ITRACONAZOLE, POSACONAZOLE, VORICONAZOLE reactions: Torsade de pointes serious: 1 patientsex: 2 drugs: DICLOFENAC reactions: Haematoma, Pyomyositis, Staphylococcal infection serious: 1 patientsex: 1 drugs: ATORVASTATIN, BICALUTAMIDE, DOCETAXEL, GLIPIZIDE, METFORMIN HYDROCHLORIDE, TADAFIL reactions: Haematuria serious: 1 patientsex: 2 drugs: PROPYLTHIOURACIL reactions: Anti-neutrophil cytoplasmic antibody positive vasculitis, Otitis media serious: 1 patientsex: 1 drugs: DEXAMETHASONE, IXAZOMIB, LENALIDOMIDE reactions: Acute kidney injury serious: 1 patientsex: 2 drugs: PAZOPANIB reactions: Acute kidney injury, Urosepsis, Pneumonitis serious: 1 patientsex: 1 drugs: CARBOPLATIN reactions: Generalised tonic-clonic seizure serious: 1 patientsex: 1 drugs: ASPIRIN, CYCLOPENTOLATE, PHENYLEPHRINE HYDROCHLORIDE, WARFARIN reactions: Intraocular pressure decreased serious: 1 patientsex: 2 drugs: NEVIRAPINE reactions: Acute HIV infection serious: 1 patientsex: 1 drugs: BRENTUXIMAB VEDOTIN, CISPLATIN, CYTARABINE, DEXAMETHASONE, PEGFILGRASTIM reactions: Anaemia, Neutropenia, Thrombocytopenia serious: 1 patientsex: 1 drugs: ECULIZUMAB reactions: Abdominal pain, Abdominal pain serious: 1 patientsex: 1 drugs: AMPHOTERICIN B, FLUCONAZOLE, ITRACONAZOLE, OXYGEN reactions: Acute kidney injury, Coccidioidomycosis, Septic shock serious: 1 patientsex: 1 drugs: ASPIRIN reactions: Cardiac arrest, Overdose, Shock serious: 1 patientsex: 1 drugs: BENDAMUSTINE, RITUXIMAB reactions: Drug ineffective, Klebsiella infection serious: 1 patientsex: 2 drugs: NATALIZUMAB reactions: Progressive multifocal leukoencephalopathy serious: 1 patientsex: 2 drugs: CLOPIDOGREL BISULFATE reactions: Quadriparesis serious: 1 patientsex: 2 drugs: DABIGATRAN ETEXILATE MESYLATE reactions: Blepharoematoma, Facial oedema, Fall, Subarachnoid haemorrhage serious: 1 patientsex: 2 drugs: FORICETISONE, PROPRANOLOL HYDROCHLORIDE reactions: Hypertensive emergency, Phaeochromocytoma serious: 1 patientsex: 2 drugs: METHOTREXATE reactions: Atrial mass, Cerebral infarction, Embolic stroke serious: 1 patientsex: 1 drugs: ACETAMINOPHEN, ETORICOXIB, PREGABALIN, TRAMADOL reactions: Drug reaction with eosinophilia and systemic symptoms serious: 1 patientsex: 1 drugs: ESCITALOPRAM OXALATE, LORAZEPAM, MIRTAZAPINE, PROPRANOLOL HYDROCHLORIDE, ZOLPIDEM TARTRATE reactions: Delirium, Withdrawal syndrome serious: 1 patientsex: 2 drugs: KETAMINE HYDROCHLORIDE reactions: Abdominal pain lower, Drug abuse, Haematuria, Klebsiella infection, Pyelonephritis serious: 1 patientsex: 1 drugs: METOPROLOL reactions: Acute respiratory failure, Chest wall weakness, Mitochondrial disorder serious: 1 patientsex: 1 drugs: LEVOFLOXACIN, OSELTAMIVIR, PIPERACILLIN SODIUMTAZOBACTAM SODIUM, VANCOMYCIN reactions: Neutropenia serious: 1 patientsex: 1 drugs: DABRAFENIB, IPILIMUMAB, METFORMIN HYDROCHLORIDE, PEMBROLIZUMAB, VEMURAFENIB, TRAMETINIB reactions: Nausea, Vomiting serious: 1 patientsex: 1 drugs: MODAFINIL reactions: Drug dependence, Drug use disorder, Irritability, Sleep disorder, Tremor serious: 1 patientsex: 2 drugs: ADALIMUMAB, ETANERCEPT, CERTOLIZUMAB PEGOL reactions: Sarcoidosis serious: 1 patientsex: 2 drugs: CLONAZEPAM, URSODIOL reactions: Atrioventricular block, Bradycardia, Cardiomegaly, Hypoalbuminaemia, Hypothyroidism, Renal impairment, Sinus node dysfunction, Sinus node dysfunction serious: 1 patientsex: 1 drugs: BLEOMYCIN SULFATE, CARBOPLATIN, DEXAMETHASONE, ETOPOSIDE, FILGRASTIM, IFOSFAMIDE, METHOTREXATE reactions: Disease recurrence, Seizure serious: 1 patientsex: 2 drugs: METHOTREXATE reactions: Cytopenia, Drug level increased, Toxicity to various agents serious: 1 patientsex: 1 drugs: BISOPROLOL, CANDESARTAN reactions: Foetal exposure during pregnancy, Hypocalvaria, Pulmonary hypoplasia serious: 1 patientsex: 2 drugs: GENTAMICIN SULFATE reactions: Dermatitis allergic, Device site dermatitis serious: 1 patientsex: 1 drugs: ACYCLOVIR, HUMAN IMMUNOGLOBULIN G, METHYLPREDNISOLONE reactions: Drug ineffective serious: 1 patientsex: 1 drugs: SUCRALFATE reactions: Calcinosis serious: 1 patientsex: 1 drugs: CYCLOPHOSPHAMIDE, RITUXIMAB reactions: Drug ineffective, Pneumonia cytomegaloviral serious: 1 patientsex: 2 drugs: ALBUTEROL, OMALIZUMAB, THEOPHYLLINE ANHYDROUS reactions: Asthma, Drug ineffective, Off label use serious: 1 patientsex: 2 drugs: FENTANYL, GLYCOPYRROLATE, NITROUS OXIDE, ROCURONIUM BROMIDE, SEVOFLURANE, THIOPENTAL SODIUM reactions: Febrile convulsion serious: 1 patientsex: 1 drugs: CETIRIZINE HYDROCHLORIDE, EPINEPHRINE, MONTELUKAST SODIUM, PREDNISOLONE reactions: Abdominal pain lower, Blood pressure decreased, Cognitive disorder, Depressed level of consciousness, Dysarthria, Fatigue, Idiopathic mast cell activation syndrome, Loss of consciousness, Mental disorder, Mental disorder, Mental disorder, Mental disorder, Mental disorder, Mental disorder, Mental disorder, Mental disorder, Mental disorder, Mental disorder, Mental disorder, Mental disorder, Mental disorder, Mental disorder, Mental disorder, Mental disorder, Mental disorder, Mental disorder, Mental disorder, Mental disorder, Mental disorder, Mental disorder, Mental disorder, Mental disorder, Mental disorder, Mental disorder, Mental disorder, Mental disorder, Mental disorder, Mental disorder, Mental disorder, Mental disorder, Mental disorder, Mental disorder, Mental disorder, Mental disorder, Mental disorder, Mental disorder, Mental disorder, Mental disorder, Mental disorder, Mental disorder, Mental disorder, Mental disorder, Mental disorder, Mental disorder, Mental disorder, Mental disorder, Mental disorder, Mental disorder, Mental disorder, Mental disorder, Mental disorder, Mental disorder, Mental disorder, Mental serious: 1 patientsex: 2 drugs: ALEDRINIC ACID, CEFUROXIME, FENTANYL, GLYCOPYRROLUM, KETAMINE, MIDAZOLAM HYDROCHLORIDE, ONDANSETRON, PROPOFOL, TRANEXAMIC ACID reactions: Anaphylactic reaction serious: 1 patientsex: 2 drugs: DEXAMETHASONE, PHENAZOLINUM reactions: Henoch-Schonlein purpura serious: 1 patientsex: 2 drugs: FERROUS SULFATE reactions: Atelectasis, Cough, Dyspnoea, Granuloma, Pulmonary consolidation, Pulmonary stenosis, Pulmonary fibrosis, Pulmonary consolidation serious: 1 patientsex: 2 drugs: ALGINIC ACID, CLEBOPIRADE, ESOMEPRAZOLE MAGNESIUM, SODIUM BICARBONATE reactions: Cognitive disorder, Drug ineffective, Fatigue, Sexual dysfunction serious: 1 patientsex: 2 drugs: NATALIZUMAB reactions: Granule cell neuropathy serious: 1 patientsex: 1 drugs: TERBINAFINE reactions: Pityriasis serious: 1 patientsex: 2 drugs: CARBOPLATIN, PACLITAXEL reactions: Pseudocirrhosis serious: 1 patientsex: 1 drugs: CLOZAPINE, OLANZAPINE, QUETIAPINE, VENLAFAXINE HYDROCHLORIDE reactions: Constipation, Drug interaction, Dry heaving, Salivary hypersecretion, Salivary hypersecretion, Somnolence serious: 1 patientsex: 2 drugs: ALENDAZOLE, CISPLATIN, CYCLOPHOSPHAMIDE, CYTARABINE, METHYLCOBALAMIN, PREDNISOLONE, RITUXIMAB, VINCRISTINE reactions: Drug interaction, Hepatic enzyme increased, Hepatic enzyme increased, Hepatic function abnormal, Hepatic enzyme increased, Hepatic function abnormal, Hepatic enzyme increased, Hepatic function abnormal, Hepatic function abnormal, Hepatic function abnormal, Hepatic function abnormal, Hepatic function abnormal, Hepatic function abnormal, Hepatic function abnormal, Hepatic function abnormal, Hepatic function abnormal, Hepatic function abnormal, Hepatic function abnormal, Hepatic function abnormal, Hepatic function abnormal, Hepatic function abnormal, Hepatic function abnormal, Hepatic function abnormal, Hepatic function abnormal, Hepatic function abnormal, Hepatic function abnormal, Hepatic function abnormal, Hepatic function abnormal, Hepatic function abnormal, Hepatic function abnormal, Hepatic function abnormal, Hepatic function abnormal, Hepati serious: 1 patientsex: 1 drugs: BLEOMYCIN SULFATE, CISPLATIN, DICLOFENAC, FILGRASTIM, VALSARTAN reactions: Dermatomyositis, Neutropenia serious: 1 patientsex: 1 drugs: DABIGATRAN ETEXILATE MESYLATE reactions: Cardiac tamponade serious: 1 patientsex: 1 drugs: IBRUTINIB reactions: COVID-19 serious: 1 patientsex: 2 drugs: DABIGATRAN ETEXILATE MESYLATE reactions: Cerebral haemorrhage serious: 1 patientsex: 2 drugs: AZATHIOPRINE, FOLIC ACID, METHYLPREDNISOLONE, SULFAMETHOXAZOLETRIMETHOPRIM reactions: Drug ineffective serious: 1 patientsex: 1 drugs: BORTEZOMIB, DEXAMETHASONE, LENALIDOMIDE reactions: Plasma cell myeloma serious: 1 patientsex: 1 drugs: CYCLOPHOSPHAMIDE, CYTARABINE, THIOTEPA, VINCRISTINE reactions: Anaemia, Diarrhoea, Fatigue, Hypernatraemia, Neutropenia, Thrombocytopenia, Urinary incontinence serious: 1 patientsex: 1 drugs: BEVACIZUMAB, CARBOPLATIN, ERLOTINIB, GEFITINIB, NIVOLUMAB, PEMETREXED reactions: Drug level increased, Interstitial lung disease serious: 1 patientsex: 1 drugs: CHOLECALCIFEROL, BEVACIZUMAB, HYDROCHLOROTHIAZIDE, LISINOPRIL reactions: Glomerulonephritis membranous serious: 1 patientsex: 1 drugs: CANAGLIFLOZIN, CIPROFLOXACIN, INSULIN GLARGINE, METFORMIN HYDROCHLORIDE, SITAGLIPTIN reactions: Fourniers gangrene serious: 1 patientsex: 1 drugs: CAPECITABINE, DOCETAXEL, FLUOROURACIL, LEUCOVORIN, OXALIPLATIN reactions: Paracoccidioidomycosis serious: 1 patientsex: 2 drugs: AMIODARONE HYDROCHLORIDE, CALCITRIOL, ERGOCALCIFEROL reactions: Hypocalcaemia, Hypomagnesaemia, Hypophosphataemia, Hypothyroidism serious: 1 patientsex: 2 drugs: ATORVASTATIN, CARVEDILOL, DIGOXIN, FUROSEMIDE, RIVAROXABAN, SPIRONOLACTONE, VALSARTAN reactions: Drug interaction, Rhabdomyolysis serious: 1 patientsex: 1 drugs: PREDNISOLONE reactions: Diabetes insipidus, Polyuria serious: 1 patientsex: 1 drugs: ILOPROST, SILDENAFIL reactions: Drug ineffective, Pneumonia serious: 1 patientsex: 2 drugs: LACOSAMIDE, LAMOTRIGINE, LEVETIRACETAM, VALPROIC ACID, TOPIRAMATE, ZONISAMIDE reactions: Drug ineffective, Hemianopia serious: 1 patientsex: 1 drugs: CASPOFUNGIN, HYDROXYCHLOROQUINE, PIPERACILLIN SODIUMTAZOBACTAM SODIUM, RITONAVIR reactions: Drug resistance, Septic shock serious: 1 patientsex: 2 drugs: PROPYLTHIOURACIL reactions: Foetal exposure during pregnancy, Hyperthyroidism, Goitre serious: 1 patientsex: 2 drugs: CYCLOSPORINE, FLUVASTATIN SODIUM, IRON, MYCOPHENOLIC ACID, PREDNISOLONE reactions: Abdominal tuberculosis serious: 1 patientsex: 1 drugs: AMOXICILLINCLAVULANIC ACID, HUMAN IMMUNOGLOBULIN G, MEROPENEM, METRONIDAZOLE, RIFAZIMINE, VANCOMYCIN reactions: Clostridium difficile infection, Drug ineffective, Inflammation, Proctitis serious: 2 patientsex: 1 drugs: MYCOPHENOLATE MOFETIL reactions: Upper respiratory tract infection serious: 1 patientsex: 1 drugs: BORTEZOMIB, DESAMETHAZONE reactions: Extravasation, Skin necrosis serious: 1 patientsex: 2 drugs: DIGOXIN, FUROSEMIDE, INSULIN NOS, NEBIVOLOL, RIVAROXABAN reactions: Spinal epidural haematoma serious: 1 patientsex: 1 drugs: CYCLOPHOSPHAMIDE, RITUXIMAB reactions: Dysphagia, Off label use, Pneumonia aspiration, Portal vein thrombosis, Peritonitis, Portal vein thrombosis, Weight decreased serious: 1 patientsex: 1 drugs: ASPIRIN, CLOPIDOGREL BISULFATE reactions: Anaemia, Cytomegalovirus enteritis, Small intestinal ulcer serious: 1 patientsex: 2 drugs: BEVACIZUMAB, CARBOPLATIN, CYCLOPHOSPHAMIDE, DOXORUBICIN, ETOPOSIDE, PACLITAXEL, TOPOTECAN HYDROCHLORIDE reactions: Disease progression serious: 1 patientsex: 1 drugs: DIGOXIN, FUROSEMIDE, SPIRONOLACTONE reactions: Atrial fibrillation, Bradycardia, Delirium, Dyspnoea, Ejection murmur, Oedema peripheral, Pleural effusion, Pulmonary congestion, Pulmonary oedema, Pulmonary congestion aspiration, Pulmonary oedema, Pulmonary congestion, Pleural effusion, Pulmonary congestion, Pulmonary congestion, Pleural effusion, Pulmonary congestion, Pulmonary oedema, Pulmonary congestion, Pulmonary oedema, Pulmonary congestion, Pulmonary oedema, Pulmonary congestion, Pulmonary oedema, Pulmonary congestion, Pulmonary oedema, Pulmonary congestion, Pulmonary oedema, Pulmonary congestion, Pulmonary oedema, Pulmonary congestion, Pulmonary oedema, Pulmonary congestion, Pulmonary oedema, Pulmonary congestion, Pulmon serious: 1 patientsex: 2 drugs: TRASTUZUMAB reactions: Loss of personal independence in daily activities, Vomiting serious: 1 patientsex: 1 drugs: ASPIRIN, CLOPIDOGREL BISULFATE, HEPARIN SODIUM, NITROGLYCERIN reactions: Quadriplegia, Spinal epidural haematoma serious: 1 patientsex: 1 drugs: GEMCITABINEGEMCITABINE HYDROCHLORIDE reactions: Organising pneumonia serious: 1 patientsex: 2 drugs: AMLODIPINE BESYLATE, BISOPROLOL, CALCITRIOL, CIPROFLOXACIN, FUROSEMIDE, IRBESARTAN, HYDROXYCHLOROQUINE, MYCOPHENOLATE MOFETIL, SEVELAMER, VANCOMYCIN reactions: Drug interaction, Rhabdomyolysis serious: 1 patientsex: 2 drugs: LEVOFLOXACIN reactions: Toxic encephalopathy serious: 1 patientsex: 2 drugs: COLCHICINE reactions: Bicytopenia, Pancreatitis, Toxicity to various agents serious: 1 patientsex: 2 drugs: AZITHROMYCIN ANHYDROUS, TAMIFLUM reactions: Haemoptysis, Lemierres syndrome, Pneumonia serious: 1 patientsex: 1 drugs: METHYLPREDNISOLONE reactions: Cytomegalovirus infection, Endophthalmitis serious: 1 patientsex: 1 drugs: ATORVASTATIN reactions: Immune-mediated necrotising myopathy serious: 1 patientsex: 2 drugs: MEROPENEM, PIPERACILLIN SODIUMTAZOBACTAM SODIUM, VANCOMYCIN reactions: Drug interaction, Drug level below therapeutic, Seizure serious: 1 patientsex: 2 drugs: PACLITAXEL, PERTUZUMAB, TRASTUZUMAB reactions: Ataxia, Eyelid ptosis, Neuropathy peripheral, Off label use, Rash haemorrhagic serious: 1 patientsex: 1 drugs: AMIKACIN, CYCLOSERINE, ETHAMBUTOL HYDROCHLORIDE, LINEZOLID, LEVOFLOXACIN, PIPERACILLIN SODIUMTAZOBACTAM SODIUM, PROTHIONAMIDE reactions: Drug-induced liver injury, Hepatitis C, Nausea, Portal fibrosis serious: 1 patientsex: 1 drugs: RIBAVIRIN, SOFOSBUVIR reactions: Hepatitis C serious: 1 patientsex: 1 drugs: EPLERENONE, NEBIVOLOL, RAMIPRIL, SODIUM ZINC CYCLOSPORINE, VALSARTAN reactions: Drug ineffective, Hyperkalaemia, Renal impairment serious: 1 patientsex: 2 drugs: CYCLOPHOSPHAMIDE, DOXORUBICIN HYDROCHLORIDE, PACLITAXEL, PERTUZUMAB, TRASTUZUMAB reactions: Bundle branch block left, Cardiomyopathy serious: 1 patientsex: 1 drugs: EVEROLIMUS, METHYLPREDNISOLONE, MYCOPHENOLATE MOFETIL, PREDNISONE, TACROLIMUS, VALGANCICLOVIR reactions: Epstein-Barr virus infection, Post transplant lymphoproliferative disorder serious: 1 patientsex: 1 drugs: SULFAMETHOXAZOLETRIMETHOPRIM reactions: Drug eruption, Pruritus, Skin lesion serious: 1 patientsex: 1 drugs: GIMERACILOTERACILTEGAFUR, OTERACIL POTASSIUM reactions: Bone marrow failure, Hepatic function abnormal serious: 1 patientsex: 2 drugs: MORPHINE SULFATE reactions: Drug ineffective, Drug intolerance, Hypercholesterolaemia, Hypertension, Hypotension, Inappropriate schedule of drug administration, Pain, Pain in extremity, Pain in extremity, Pain in extremity, Pain in extremity, Pain in extremity, Pain in extremity, Pain in extremity, Pain in extremity, Pain in extremity, Pain in extremity, Pain in extremity, Pain in extremity, Pain in extremity, Pain in extremity, Pain in extremity, Pain in extremity, Pain in extremity, Pain in extremity, Pain in extremity, Pain in extremity, Pain in extremity, Pain in extremity, Pain in extremity, Pain in extremity, Pain in extremity, Pain in extremity, Pain in extremity, Pain in extremity, Pain in extremity, Pain in extremity, Pain in extremity, Pain in extremity, Pain in extremity, Pain in extremity, Pain in extremity, Pain in extremity, Pain in extremity, Pain in extremity, Pain in extremity, Pain in extremity, Pain in extremity serious: 1 patientsex: 1 drugs: DARUNAVIR, DOLUTEGRAVIR, EMTRICITABINERILPIVIRINE HYDROCHLORIDE, RITONAVIR, TENOFOVIR DISOPROXIL FUMARATE reactions: Immune reconstitution inflammatory syndrome, Thyroid eye disease serious: 1 patientsex: 2 drugs: ANASTRAZOLE, FONDAPARINUX, TAMOXIFEN, TICLOPIDINE, WARFARIN reactions: Antiphospholipid syndrome serious: 1 patientsex: 1 drugs: AZATHIOPRINE, CYCLOSPORINE, LIDOCAINE, METHYLPREDNISOLONE, MEXILETINE reactions: Cytomegalovirus infection, Colitis, Off label use, Tracheosis, Transaminases increased serious: 1 patientsex: 1 drugs: SILDENAFIL reactions: Enterococcal infection, Peritonitis serious: 1 patientsex: 2 drugs: METHYLPHENIDATE HYDROCHLORIDE reactions: Tongue biting serious: 1 patientsex: 1 drugs: CYCLOSPORINE, METHOTREXATE, RUXOLITINIB, VINCRISTINE reactions: Graft versus host disease serious: 1 patientsex: 1 drugs: FLECAINIDE, METOPROLOL TARTRATE reactions: Cardiac arrest, Toxicity to various agents serious: 1 patientsex: 1 drugs: DESFLURANE, PROPOFOL, REMIFENTANIL, ROCURONIUM BROMIDE reactions: Bradycardia, Trigeminal cardiac reflex serious: 1 patientsex: 1 drugs: CISPLATIN, GEMCITABINEGEMCITABINE HYDROCHLORIDE reactions: Abdominal pain upper, Neuropathy peripheral, Thrombocytopenia serious: 1 patientsex: 1 drugs: ASPIRIN, ATORVASTATIN, LOSARTAN reactions: Apis-dorsata sting, Ischaemia serious: 1 patientsex: 1 drugs: CISPLATIN, DOCETAXEL, ERLOTINIB, PEMETREXED reactions: Asthenia, Neuropathy peripheral, Nail toxicity serious: 1 patientsex: 2 drugs: ADALIMUMAB, INFLIXIMAB, METHOTREXATE, PREDNISOLONE, TOCILIZUMAB reactions: Drug ineffective, Eosinophilia, Skin disorder serious: 1 patientsex: 2 drugs: TESTOSTERONE reactions: Breast cancer, Invasive ductal breast carcinoma serious: 1 patientsex: 1 drugs: ATEZOLIZUMAB reactions: Acute respiratory failure, Confusional state, Hypercalcaemia, Lethargy, Pneumonia, Respiratory failure serious: 1 patientsex: 1 drugs: ALBUTEROL, ENOXAPARIN, LEVETIRACETAM, ONDANSETRON, TRAMADOL reactions: Alanine aminotransferase increased, Aspartate aminotransferase increased, Drug interaction, Hepatic enzyme increased, Hepatitis A, Hepatitis B surface antibody positive, Hepatitis B surface antibody negative, Hepatitis B surface antibody positive, Hepatitis B surface antibody positive, Hepatitis B surface antibody positive, Hepatitis B surface antibody positive, Hepatitis B surface antibody positive, Hepatitis B surface antibody positive, Hepatitis B surface antibody positive, Hepatitis B surface antibody positive, Hepatitis B surface antibody positive, Hepatitis B surface antibody positive, Hepatitis B surface antibody positive, Hepatitis B surface antibody positive, Hepatitis B surface antibody positive, Hepatitis B surface antibody positive, Hepatitis B surface antibody positive, Hepatitis B surface antibody positive, Hepatitis B surface antibody positive, Hepatitis B surface antibody positive serious: 1 patientsex: 1 drugs: ASPIRIN, RAMIPRIL, SIMVASTATIN, SITAGLIPTIN reactions: Cholangiocarcinoma, Hypercalcaemia, Syncope serious: 1 patientsex: 2 drugs: BUSULFAN, FLUDARABINE PHOSPHATE, SIROLIMUS, TACROLIMUS reactions: Mycosis fungoides serious: 1 patientsex: 1 drugs: CARBIDOPALEVODOPA, PRAMIPEXOLE, QUETIAPINE, TRIHEXYPHENIDYL reactions: Catatonia serious: 1 patientsex: 2 drugs: ONDANSETRON reactions: Acute coronary syndrome, Drug hypersensitivity, Kounis syndrome serious: 1 patientsex: 1 drugs: ASPIRIN, CYPROHEPTADINE, HYDROXYZINE HYDROCHLORIDE, GUANFACINE reactions: Aggression, Drug ineffective, Headache, Suicidal ideation serious: 1 patientsex: 2 drugs: RANIBIZUMAB reactions: Retinal exudates, Subretinal fluid serious: 1 patientsex: 1 drugs: AZITHROMYCIN ANHYDROUS, DEXTROSE, ESMOLOL, OCTREOTIDE, PROPRANOLOL HYDROCHLORIDE reactions: Necrotising colitis, Rotavirus infection serious: 1 patientsex: 1 drugs: CYCLOPHOSPHAMIDE, DOXORUBICIN, PREDNISOLONE, VINCRISTINE reactions: Cardio-respiratory collapse, Pneumothorax serious: 1 patientsex: 1 drugs: CITRATE reactions: Intestinal tuberculosis, Paradoxical drug reaction serious: 1 patientsex: 1 drugs: CYCLOPHOSPHAMIDE, FLUDARABINE PHOSPHATE, METHOTREXATE, MYCOPHENOLATE MOFETIL, PREDNISONE reactions: Epstein-Barr virus infection, Post transplant lymphoproliferative disorder serious: 1 patientsex: 1 drugs: ADALIMUMAB, BUDESONIDE, INFLIXIMAB reactions: Crohns disease serious: 1 patientsex: 2 drugs: COLCHICINE, PREDNISONE, TRIAMCINOLONE reactions: Gastrointestinal disorder serious: 1 patientsex: 2 drugs: AMLODIPINE BESYLATE, CANDESARTAN, LENVATINIB reactions: Focal segmental glomerulosclerosis serious: 1 patientsex: 2 drugs: ALEMTUZUMAB, GLATIRAMER ACETATE, METHYLPREDNISOLONE, OCRELIZUMAB, PEGINTERFERON BETA-1A reactions: Exposure during pregnancy, Premature delivery serious: 1 patientsex: 2 drugs: ARSENIC TRIOXIDE, DEXAMETHASONE, IDARUBICIN, TRETINOIN reactions: Neutropenic sepsis, Respiratory failure serious: 1 patientsex: 1 drugs: CYCLOSPORINE, METHYLPREDNISOLONE, PREDNISOLONE, RITUXIMAB reactions: Aplasia pure red cell serious: 1 patientsex: 1 drugs: ATRIPLA, TENOFOVIR DISOPROXIL FUMARATE reactions: Fracture serious: 1 patientsex: 2 drugs: CIPROFLOXACIN, METRONIDAZOLE reactions: Acute kidney injury, Crystal deposit nephropathy serious: 1 patientsex: 2 drugs: FLUOROURACIL, LEUCOVORIN, OXALIPLATIN, TRASTUZUMAB reactions: Neuropathy peripheral serious: 1 patientsex: 1 drugs: SULFAMETHOXAZOLETRIMETHOPRIM reactions: Drug-induced liver injury, Encephalitis, Pneumonia necrotising, Pulmonary toxoplasmosis, Shock serious: 1 patientsex: 2 drugs: ISOPROTERENOL reactions: Arteriospasm coronary, Bradycardia, Hypotension, Syncope serious: 1 patientsex: 1 drugs: CISPLATIN reactions: Blood creatinine increased, Glomerular filtration rate decreased serious: 1 patientsex: 2 drugs: HYDROXYCHLOROQUINE reactions: Drug ineffective, Lupus nephritis serious: 1 patientsex: 2 drugs: CEFAZOLIN, DESFLURANE, FENTANYL, REMIFENTANIL, ROCURONIUM BROMIDE, THIAMYLAL reactions: Kounis syndrome serious: 1 patientsex: 1 drugs: CIPROFLOXACIN, PREDNISOLONE ACETATE reactions: Corneal abscess, Eye pain, Eye redness, Eye pain, Eye pain, Vision blurred serious: 1 patientsex: 2 drugs: CEFTAZIDIME, DOXYCYCLINE, MEROPENEM, MEROPENEMIMIPENEM reactions: Pancytopenia serious: 1 patientsex: 2 drugs: DISOPYRAMIDE, FLUNITRAZEPAM reactions: Cardiac arrest, Endocarditis, Intentional overdose, Sepsis, Staphylococcal infection serious: 1 patientsex: 2 drugs: MYCOPHENOLATE MOFETIL, PREDNISOLONE, TACROLIMUS reactions: Meningitis bacterial, Type I infection serious: 1 patientsex: 2 drugs: BEVACIZUMAB, FONDAPARINUX, LEVETIRACETAM, PALBOCICLIB, POTASSIUM reactions: Abdominal pain, Ascites, Coma, Confusional state, Disorientation, Headache, Hypomagnesaemia, Lethargy, Lethargy, Oedema peripheral, Posterior reversible encephalopathy syndrome, Vomiting serious: 1 patientsex: 1 drugs: DAPTOMYCIN, LINEZOLID, NAFCILLIN, TELAVINCIN reactions: Drug ineffective serious: 1 patientsex: 2 drugs: DEXAMETHASONE, THALIDOMIDE reactions: Acute myeloid leukaemia serious: 1 patientsex: 1 drugs: CLONAZEPAM, CLOZAPINE, FLUPHENAZINE DECANOATE, OLANZAPINE, RISPERIDONE reactions: Dystonia, Tardive dyskinesia serious: 1 patientsex: 1 drugs: CLONIDINE, ENALAPRIL, NITROGLYCERIN, METOPROLOL, PRAZOSIN reactions: Hyperkalaemia, Neutropenia serious: 1 patientsex: 2 drugs: CYCLOPHOSPHAMIDE, HUMAN IMMUNOGLOBULIN G, RITUXIMAB reactions: Drug ineffective serious: 1 patientsex: 1 drugs: FLUOXETINE HYDROCHLORIDE, LITHIUM CARBONATE, OLANZAPINE, QUETIAPINE, VALPROIC ACID reactions: Drug ineffective, Drug interaction, Drug level decreased, Drug level increased, Drug level decreased, Drug level increased, Drug level decreased, Drug level increased, Drug level decreased, Drug level increased, Drug level decreased, Drug level increased, Drug level decreased, Drug level increased, Drug level decreased, Drug level increased, Drug level decreased, Drug level increased, Drug level decreased, Drug level increased, Drug level decreased, Drug level increased, Drug level decreased, Drug level increased, Drug level decreased, Drug level increased, Drug level decreased, Drug level increased, Drug level decreased, Drug level increased, Drug level decreased, Drug level increased, Drug level decreased, Drug level increased, Drug level decreased, Drug level increased, Drug level decreased, Drug level increased, Drug level decreased, Drug level increased, Drug level decreased, Drug level increased, Drug level decreased, Drug level increased, Drug level decreased, Drug level increased, Drug level decreased, Drug level increased, Drug level decreased, Drug level increased, Drug level decreased, serious: 1 patientsex: 2 drugs: CLONIDINE, HYDRALAZINE HYDROCHLORIDE, METOPROLOL, PERINDOPRIL, ROSUVASTATIN, WARFARIN reactions: Anti-neutrophil cytoplasmic antibody positive vasculitis, Glomerulonephritis acute, Streptococcal bacteraemia serious: 1 patientsex: 2 drugs: ATORVASTATIN, CARVEDILOL, HYDROCHLOROTHIAZIDE, MIRTAZAPINE, LOSARTAN reactions: Hypercalcaemia, Urinary tract infection bacterial serious: 1 patientsex: 1 drugs: BENDAMUSTINE, CYCLOSPORINE, FLUDARABINE PHOSPHATE, MELPHALAN, METHOTREXATE, RITUXIMAB reactions: Clostridium difficile colitis, Febrile neutropenia, Myelodysplastic syndrome, Neutropenia serious: 1 patientsex: 1 drugs: ALLOPURINOL reactions: Drug reaction with eosinophilia and systemic symptoms serious: 1 patientsex: 1 drugs: ABACAVIR, ATAZANAVIR, DIDANOSINE, LAMIVUDINE, RITONAVIR, TRIAMCINOLONE reactions: Adrenal insufficiency, Drug interaction, Hypothalamic pituitary axis suppression, Product use in unapproved indication serious: 1 patientsex: 1 drugs: BISOPROLOL, DENOSUMAB, DOXAZOSIN MESYLATE, LANREOTIDE, TEMOZOLOMIDE reactions: Metastases to bone, Metastases to spine, Metastases to lung, Metastases to liver, Metastases to lung, Metastases to spine, Metastases to spine, Metastases to lung, Metastases to spine, Metastases to spine, Metastases to spine, Metastases to spine, Metastases to spine, Metastases to spine, Metastases to spine, Metastases to spine, Metastases to spine, Metastases to spine, Metastases to spine, Metastases to spine, Metastases to spine, Metastases to spine, Metastases to spine, Metastases to spine, Metastases to spine, Metastases to spine, Metastases to spine, Metastases to spine, Metastases to spine, Metastases to spine, Metastases to spine, Metastases to spine, Metastases to spine, Metastases to spine, Metastases serious: 2 patientsex: 2 drugs: METFORMIN HYDROCHLORIDE, EXENATIDE reactions: Treatment noncompliance serious: 1 patientsex: 1 drugs: IBUPROFEN reactions: Bacteraemia, Endocarditis, Spinal epidural abscess serious: 1 patientsex: 2 drugs: CISPLATIN, DOCETAXEL, GEMCITABINE, METHOTREXATE, METHYLPREDNISOLONE, METHYLPREDNISOLONE SODIUM SUCCINATE, METHYLPREDNISOLONE ACETATE, METHYLPREDNISOLONE SODIUM SUCCINATE, METHYLPREDNISOLONE ACETATE, METHYLPREDNISOLONE SODIUM SUCCINATE, METHYLPREDNISOLONE ACETATE, METHYLPREDNISOLONE SODIUM SUCCINATE, METHYLPREDNISOLONE SODIUM SUCCINATE, METHYLPREDNISOLONE SODIUM SUCCINATE, METHYLPREDNISOLONE SODIUM SUCCINATE, METHYLPREDNISOLONE SODIUM SUCCINATE, METHYLPREDNISOLONE SODIUM SUCC serious: 1 patientsex: 1 drugs: DABIGATRAN ETEXILATE MESYLATE, NEBIVOLOL, SPIRONOLACTONE, VENLAFAXINE HYDROCHLORIDE reactions: Brain oedema, Cerebral haemorrhage, Subdural haematoma serious: 1 patientsex: 2 drugs: ASPIRIN, TICAGRELOR reactions: Haematochezia, Haemoptysis, Mucosal haemorrhage, Oedema, Oedema peripheral, Petechial haemorrhage, Peripheral ulceration, Peripheral haemorrhage, Peripheral ulceration, Peripheral haemorrhage, Peripheral haemorrhage, Peripheral ulceration, Peripheral haemorrhage, Peripheral haemorrhage, Peripheral ulceration, Peripheral haemorrhage, Peripheral haemorrhage, Peripheral haemorrhage, Peripheral haemorrhage, Peripheral haemorrhage, Peripheral haemorrhage, Peripheral haemorrhage, Peripheral haemorrhage, Peripheral haemorrhage, Peripheral serious: 1 patientsex: 1 drugs: FLUNITRAZEPAM, GABAPENTIN, VALPROIC ACID reactions: Drug interaction, Gait disturbance serious: 1 patientsex: 1 drugs: CYCLOPHOSPHAMIDE, DOXORUBICIN, PREDNISONE, RITUXIMAB, VINCRISTINE reactions: Febrile neutropenia, Intestinal mucosal inflammation, Pneumonia serious: 1 patientsex: 2 drugs: AMLODIPINE BESYLATE, CLONAZEPAM, DONEPEZIL, GABAPENTIN, LOSARTAN, RIVASTIGMINE reactions: Anxiety, Confusional state, Fall, Fall prone, Fall, Fall, Confusional state, Fall, Fall, Fall, Fall, Fall, Fall, Fall, Fall, Fall, Fall, Gait disturbance, Hallucination, visual, Loss of personal independence in daily activities, Mobility decreased, Mental status changes, Mental status changes, Mental status changes, Mental status changes, Mental status changes, Mental status changes, Mental status changes, Mental status changes, Mental status changes, Mental status changes, Mental status changes, Mental status changes, Mental status changes, Mental status changes, Mental status changes, Mental status changes, Mental status changes, Mental status changes, Mental status changes, Mental status changes, Mental status changes, Mental status changes, Mental status changes, Mental status changes, Mental status changes, Mental status changes, Mental status changes, Mental status changes, Mental status changes, Mental status changes, Mental status changes, Mental status changes, Mental status changes, Mental status changes, Mental status serious: 1 patientsex: 2 drugs: EFAVIRENZ, EMTRICITABINE, NYSTATIN, TENOFOVIR DISOPROXIL FUMARATE reactions: Immune reconstitution inflammatory syndrome, Off label use, Product use in unapproved indication serious: 1 patientsex: 2 drugs: ACETAMINOPHEN reactions: Drug-induced liver injury, Procalcitonin increased, Toxicity to various agents serious: 1 patientsex: 1 drugs: OCTREOTIDE ACETATE reactions: Cardiac failure, Drug ineffective serious: 1 patientsex: 2 drugs: MOXIFLOXACIN, PREDNISOLONE, TRIAMCINOLONE reactions: Cystoid macular oedema, Drug resistance serious: 1 patientsex: 1 drugs: LEVETIRACETAM, OXCARBAZEPINE reactions: Status epilepticus serious: 1 patientsex: 1 drugs: ALPRAZOLAM, FENTANYL, HERBALS, TETRAHYDROXYCANNABINE, TRAMADOL reactions: Acute respiratory failure, Cardiogenic shock, End organ dysfunction syndrome, Hypotension, Multiple organ dysfunction syndrome, Toxic leukoencephalopathy serious: 1 patientsex: 1 drugs: PEMBROLIZUMAB reactions: Acute kidney injury, Diabetic ketoacidosis, Off label use, Type 1 diabetes mellitus serious: 1 patientsex: 1 drugs: FOLIC ACID, HYDROXYCHLOROQUINE, LEFLUNOMIDE, METHOTREXATE, SULFASALAZINE reactions: Alanine aminotransferase increased, Alanine aminotransferase increased, Alanine aminotransferase increased, Alanine aminotransferase increased, Alanine aminotransferase increased, Alanine aminotransferase increased, Alanine aminotransferase increased, Alanine aminotransferase increased, Alanine aminotransferase increased, Alanine aminotransferase increased, Alanine aminotransferase increased, Alanine aminotransferase increased, Alanine aminotransferase increased, Alanine aminotransferase increased, Alanine aminotransferase increased, Alanine aminotransferase increased, Alanine aminotransferase increased, Alanine aminotransferase increased, Alanine aminotransferase increased, Alanine aminotransferase increased, Alanine aminotransferas serious: 1 patientsex: 1 drugs: ALFETANIL, GLYCOPYRROLATE, OXYGEN, SEVOFLURANE, THIOPENTAL SODIUM, VECURONIUM BROMIDE reactions: Tube complication serious: 1 patientsex: 2 drugs: METHOTREXATE reactions: Hypersensitivity pneumonitis serious: 1 patientsex: 1 drugs: ACETAMINOPHEN, GINGKGO BILOBALA, OXYCODONE, TADALAFIL reactions: Drug interaction, Penile haematoma, Ecchymosis serious: 1 patientsex: 1 drugs: ADALIMUMAB, METHOTREXATE reactions: Biliary giardiasis serious: 1 patientsex: 2 drugs: CLOFARABINE, POSACONAZOLE reactions: Multiple organ dysfunction syndrome, Sepsis serious: 1 patientsex: 1 drugs: FLUOROURACIL, LEUCOVORIN, OXALIPLATIN reactions: Encephalopathy serious: 1 patientsex: 2 drugs: ENOXAPARIN, WARFARIN reactions: Nervous system disorder, Wound haematoma serious: 1 patientsex: 2 drugs: VALPROIC ACID reactions: Bradycardia, Off label use serious: 1 patientsex: 1 drugs: ABACAVIR, ATAZANAVIR, LAMIVUDINE, RITONAVIR reactions: Condition aggravated, Fall, Gait disturbance, Hyperreflexia, Leukoencephalopathy, Multiple injuries, Speech disorder, Therapeutic response decreased serious: 1 patientsex: 1 drugs: ALBUTEROL, IPRATROPIUM BROMIDE reactions: Condition aggravated, Pneumomediastinum, Subcutaneous emphysema serious: 2 patientsex: 2 drugs: BUPIVACAINE, FENTANYL, LIDOCAINE, MIDAZOLAM reactions: Foetal exposure during pregnancy serious: 1 patientsex: 1 drugs: BEVACIZUMAB, TRIAMCINOLONE ACETONIDE reactions: Blindness, Inflammation, Iridocyclitis, Ocular redness, Photophobia, Phacoantigenic uveitis serious: 1 patientsex: 1 drugs: CYCLOPHOSPHAMIDE, DOXORUBICIN, ETOPOSIDE, METHOTREXATE, RITUXIMAB, VINCRISTINE reactions: Burkitts lymphoma serious: 1 patientsex: 1 drugs: CIPROFLOXACIN, LEDIPASVIRSOFOSBUVIR reactions: Drug-induced liver injury, Hematemesis, Jaundice, Portal hypertensive gastropathy, Paracoccus infection, Septic shock serious: 1 patientsex: 1 drugs: HUMAN HUMAN GLOBULIN NOS reactions: Arthritis bacterial, Drug abuse, Mediastinal mass, Staphylococcal infection serious: 1 patientsex: 1 drugs: ASPIRIN, BICALUTAMIDE, DENOSUMAB, DEGARELIX, FLUTAMIDE, OLOPADACINE reactions: Hepatic function abnormal, Osteonecrosis jaw, Seizure serious: 1 patientsex: 1 drugs: CAPECITABINE, CISPLATIN, GEMCITABINEGEMCITABINE HYDROCHLORIDE, OXALIPLATIN, PACLITAXEL, VINORELBINEVINORELBINE TARTRATE reactions: Drug ineffective, Neuropathy peripheral serious: 1 patientsex: 1 drugs: HUMAN IMMUNOGLOBULIN G, THEOPHYLLINE ANHYDROUS, TERBUTALINE reactions: Acute kidney injury, Blood creatinine increased, Blood phosphorus increased, Blood urea increased, Blood urea decreased, Blood urea increased, Blood urea decreased, Blood urea increased, Blood urea decreased, Blood urea increased, Blood urea increased, Blood urea decreased, Blood urea increased, Blood urea decreased, Blood urea increased, Blood urea decreased, Blood urea increased, Blood urea increased, Blood urea decreased, Blood urea increased, Blood urea increased, Blood urea decreased, Blood urea increased, Blood urea increased, Blood urea decreased, Blood urea increased, Blood urea increased, Blood urea increased, Blood urea increased, Blood urea increased, Blood urea increased, Blood urea increased, Blood urea increased, Blood urea increased, Blood urea increased, Blood urea increased, Blood serious: 1 patientsex: 2 drugs: BORTEZOMIB, DARATUMUMAB, LISINOPRIL, MYCOPHENOLATE MOFETIL, PREDNISONE, RITUXIMAB reactions: Bone marrow failure serious: 1 patientsex: 2 drugs: FLUOROURACIL, LEUCOVORIN, OXALIPLATIN reactions: Diarrhoea, Palmar-plantar erythrodysaesthesia syndrome serious: 1 patientsex: 1 drugs: LEVETIRACETAM, MANNITOL reactions: Hyperammonaemia, Seizure serious: 1 patientsex: 2 drugs: CYCLOPHOSPHAMIDE, DOXORUBICIN, PREDNISONE, RITUXIMAB, VINCRISTINE reactions: Abdominal pain, Abdominal distension, Abdominal pain, Ascites, Blood bilirubin increased, Blood phosphorus increased, Blood leukocytosis, Blood urea increased, Blood phosphorus increased, Blood urea increased, Blood phosphorus increased, Blood urea increased, Blood phosphorus increased, Blood urea increased, Blood phosphorus increased, Blood urea increased, Blood phosphorus increased, Blood urea increased, Blood phosphorus increased, Blood urea increased, Blood phosphorus increased, Blood urea increased, Blood phosphorus increased, Blood urea increased, Blood urea increased, Blood phosphorus increased, Blood urea increased, Blood phosphorus increased, Blood urea increased, Blood phosphorus increased, Blood urea increased, Blood phosphorus increased, Blood urea increased, Blood phosphorus increased, Blood urea increased, Blood serious: 1 patientsex: 2 drugs: ACETAMINOPHENASPIRINCAFFEINE, IBUPROFEN, SUCRALFATE reactions: Duodenal ulcer, Gastric outlet obstruction, Peptic ulcer serious: 1 patientsex: 2 drugs: CISPLATIN, GEMCITABINEGEMCITABINE HYDROCHLORIDE reactions: Bone marrow failure, Gastrointestinal disorder serious: 1 patientsex: 1 drugs: FLUOROURACIL, LEUCOVORIN, OXALIPLATIN, PANITUMUMAB, PREDNISOLONE reactions: Neuropathy peripheral, Rash serious: 1 patientsex: 1 drugs: ACETAMINOPHEN, DEXTROMETHORPHAN, PROPYLENE GLYCOL 3350 reactions: Acute kidney injury, Coagulopathy, Drug interaction, Hypotension, Lactic acidosis, Overdose, Polyuria, Toxicity to various agents serious: 1 patientsex: 1 drugs: FENTANYL, MIDAZOLAM HYDROCHLORIDE, XYLOCAINE reactions: Chest wall rigidity serious: 1 patientsex: 2 drugs: CYCLOPHOSPHAMIDE, DOXORUBICIN HYDROCHLORIDE, ENAPRIL reactions: Drug interaction serious: 1 patientsex: 2 drugs: ALEMTUZUMAB, CYCLOPHOSPHAMIDE, CYTARABINE, DEXAMETHASONE, CISPLATIN, CYCLOSPORINE, FLUDARABINE PHOSPHATE, MYCOPHENOLATE MOFETIL, PREDNISONE, ROMIDEPSIN, VINCRISTINE reactions: Drug ineffective, Febrile state, Off label use, Pancytopenia, Renal failure, Splenomegaly serious: 1 patientsex: 2 drugs: IMIQUIMOD reactions: Hypomelanosis, Skin depigmentation serious: 1 patientsex: 1 drugs: CEFTRIAXONE, DOXYCYCLINE reactions: Fusobacterium infection, Lemierres syndrome serious: 1 patientsex: 1 drugs: ETHAMBUTOL HYDROCHLORIDE, ISONIAZID, PYRAZINAMIDE, RIFAMPIN reactions: Chylothorax serious: 1 patientsex: 1 drugs: NIVOLUMAB reactions: Chorea, Dyskinesia, Hyperkinesia serious: 1 patientsex: 2 drugs: MEGESTROL ACETATE reactions: Abdominal pain, Nausea serious: 1 patientsex: 2 drugs: ADALIMUMAB, BUDESONIDE, INFLIXIMAB, MESALAMINE reactions: Atypical haemolytic uraemic syndrome, Crohns disease, Thrombotic microangiopathy serious: 1 patientsex: 1 drugs: METHOTREXATE reactions: Status epilepticus, Toxic neurotoxicity serious: 1 patientsex: 1 drugs: ASPIRIN, LISINOPRIL, PROPRANOLOL HYDROCHLORIDE reactions: Haematuria, IgA nephropathy, Proteinuria serious: 2 patientsex: 1 drugs: LACOSAMIDE, LEVETIRACETAM, VALPROIC ACID reactions: Suicidal ideation serious: 1 patientsex: 1 drugs: RISPERIDONE reactions: Posture abnormal serious: 1 patientsex: 1 drugs: NIVOLUMAB reactions: Deep vein thrombosis serious: 1 patientsex: 1 drugs: BESILLOXACIN, PREDNISOLONE, TOBRAMYCIN, VALACYCLOVIR HYDROCHLORIDE reactions: Corneal infiltrates, Corneal oedema, Corneal infiltrates, Corneal infiltrates, Corneal infiltrates, Corneal infiltrates, Corneal infiltrates, Corneal infiltrates, Corneal infiltrates, Corneal infiltrates, Corneal infiltrates, Corneal infiltrates, Corneal infiltrates, Corneal infiltrates, Corneal infiltrates, Corneal infiltrates, Corneal infiltrates, Corneal infiltrates, Corneal infiltrates, Corneal infiltrates, Corneal infiltrates, Corneal infiltrates, Corneal infiltrates, Corneal in serious: 1 patientsex: 1 drugs: ALPRAZOLAM, GABAPENTIN, LISDEXAMFETAMINE, NORTRIPTYLINE reactions: Anorgasmia serious: 1 patientsex: 1 drugs: ARIPIPRAZOLE, AMPHETAMINE, DEXTROMETHORPHAN, DULOXETINE reactions: Seizure serious: 1 patientsex: 1 drugs: PHENIRAMINE MALEATE reactions: Acute kidney injury, Coma, Generalised tonic-clonic seizure, Multiple organ dysfunction syndrome, Overdose, Renal failure, Seizure, Tachycardia, Tachypnoea serious: 1 patientsex: 2 drugs: CISPLATIN, GEMCITABINEGEMCITABINE HYDROCHLORIDE, FLUOROURACIL reactions: Stevens-Johnson syndrome serious: 1 patientsex: 2 drugs: ASPIRIN, DULOXETINE, GLICLAZIDE, INSULIN GLARGINE, ROSUVASTATIN reactions: Hypertensive crisis serious: 1 patientsex: 1 drugs: AMISULPRIDE, ARIPIPRAZOLE, CLOZAPINE, FLUPENTHIXOL, HALOPERIDOL, RISPERIDONE reactions: Cardiac failure, Cardiomyopathy serious: 1 patientsex: 2 drugs: MESALAMINE, MESALAMINE MESYLATE, PREDNISOLONE reactions: Exposure during pregnancy, Premature delivery serious: 1 patientsex: 1 drugs: ALBUTEROL, ALBUTEROL SULFATE, AMINOPHYLLINE, BUDESONIDEFORMOTEROL, MAGNESIUM SULFATE, SEVOFLURANE reactions: Drug ineffective serious: 1 patientsex: 2 drugs: CISPLATIN reactions: Febrile neutropenia serious: 1 patientsex: 1 drugs: CAPECITABINE, DEXAMETHASONE, GEMCITABINEGEMCITABINE HYDROCHLORIDE, CHLORPHENIRAMINE MALEATE, GEMCITABINEGEMCITABINE HYDROCHLORIDE, ONDANSETRON, RANITIDINE, SODIUM CHLORIDE reactions: Anaemia, Peripheral neuropathy serious: 1 patientsex: 2 drugs: APIXABAN, DILTIAZEM, FUROSEMIDE, LEVETIRACETAM, METOLAZONE, METOPROLOL, ROMIPLOSTIM reactions: Pericardial haemorrhage, Pleural effusion serious: 1 patientsex: 2 drugs: VALPROIC ACID reactions: Intentional overdose, Seizure, Sinus tachycardia serious: 1 patientsex: 1 drugs: CYCLOSPORINE, IRBESARTAN, PERINDOPRIL reactions: Hypotension, Renal tubular disorder serious: 1 patientsex: 2 drugs: SERTRALINE HYDROCHLORIDE reactions: Confusional state, Hypoglycaemia, Presyncope serious: 1 patientsex: 2 drugs: CIPROFLOXACIN, FLUCONAZOLE, LACTULOSE, NADOLOL, SPIRONOLACTONE, RIFAZIMINE reactions: Posterior reversible encephalopathy syndrome serious: 1 patientsex: 1 drugs: BLEOMYCIN SULFATE, CISPLATIN, ETOPOSIDE reactions: Arteriospasm coronary serious: 1 patientsex: 1 drugs: CYCLOPHOSPHAMIDE, DOXORUBICIN, PREDNISONE, RITUXIMAB, VINCRISTINE reactions: Cardiac arrest, Drug ineffective serious: 1 patientsex: 2 drugs: VANCOMYCIN reactions: Seroma serious: 1 patientsex: 1 drugs: NINTEDANIB reactions: Hepatitis acute serious: 1 patientsex: 2 drugs: ACETAMINOPHEN, FULVESTRAN ETEXILATE MESYLATE, PALBOCICLIB, SIMVASTATIN, TRAMADOL reactions: Drug interaction, Rhabdomyolysis serious: 1 patientsex: 1 drugs: ERTAPENEM SODIUM, VANCOMYCIN reactions: Drug ineffective serious: 1 patientsex: 2 drugs: METHOTREXATE reactions: Acute kidney injury, Exposure during pregnancy, Pulmonary oedema, Sepsis serious: 1 patientsex: 2 drugs: CYTARABINE, IDARUBICIN, FLUDARABINE PHOSPHATE, RITUXIMAB, TACROLIMUS, RUXOLITINIB reactions: Bronchopulmonary aspergillosis, Drug ineffective, Off label use, Pulmonary alveolar proteinosis serious: 1 patientsex: 1 drugs: CYCLOSPORINE, METHYLPREDNISOLONE, PREDNISONE, TEICOPLANIN reactions: Acute myocarditis, Anaemia, Cardiac arrest, Cardiogenic shock, Drug ineffective, Hypotension, Oliguria, Thrombocytopenia serious: 1 patientsex: 2 drugs: CAPTOPRIL, FUROSEMIDE, HUMAN IMMUNOGLOBULIN G, METHYLPREDNISOLONE, PREDNISONE, RITUXIMAB reactions: Drug ineffective serious: 1 patientsex: 2 drugs: CASPOFUNGIN, FLUCONAZOLE reactions: Fungal infection, Device related infection serious: 1 patientsex: 1 drugs: CYTARABINE, DEXAMETHASONE, IDARUBICIN, METHOTREXATE, RITUXIMAB reactions: Alopecia, Asthenia, Bone pain, Dysphonia, Fatigue, Nausea, Neutropenia, Off label use, Pyrexia, Rash, Skin toxicity, Vomiting serious: 1 patientsex: 2 drugs: LIDOCAINE, METHYLPREDNISOLONE reactions: Arachnoiditis serious: 1 patientsex: 1 drugs: CISPLATIN, ETOPOSIDE, POTASSIUM CHLORIDE, NIELASTA reactions: Clostridium difficile colitis, Diarrhoea, Shock serious: 1 patientsex: 1 drugs: CISPLATIN, GEMCITABINEGEMCITABINE HYDROCHLORIDE, PEMETREXED reactions: Disease progression serious: 1 patientsex: 1 drugs: BORTEZOMIB, ASPARAGINASE, CYCLOPHOSPHAMIDE, DEXAMETHASONE, FLUDARABINE PHOSPHATE, IDARUBICIN, PEGASPARGASE, VINCRISTINE reactions: Drug ineffective, Pulmonary infection serious: 1 patientsex: 2 drugs: CISPLATIN reactions: Posterior reversible encephalopathy syndrome serious: 1 patientsex: 1 drugs: APIXABAN reactions: Acute kidney injury, Renal haematoma, Renal pseudoaneurysm serious: 1 patientsex: 1 drugs: BEVACIZUMAB, CARBOPLATIN, PACLITAXEL reactions: Disease progression, Skin eruption serious: 1 patientsex: 2 drugs: DICLOFENAC SODIUM reactions: Anaphylactic reaction serious: 1 patientsex: 2 drugs: ETHAMBUTOL HYDROCHLORIDE, ISONIAZID, PYRAZINAMIDE, PREDNISONE, RIFAMPIN reactions: Disease progression, Drug ineffective serious: 1 patientsex: 1 drugs: AMIODARONE HYDROCHLORIDE, CARBIMAZOLE reactions: Acute pulmonary oedema, Drug ineffective, Hyperthyroidism serious: 1 patientsex: 2 drugs: OLAPARIB reactions: Anaemia serious: 1 patientsex: 2 drugs: APIXABAN, FLECAINIDE, METOPROLOL SUCCINATE reactions: Atrioventricular block first degree, Atrioventricular block second degree, Fatigue, Sinus bradycardia, Toxicity to various agents serious: 1 patientsex: 1 drugs: DOCETAXEL reactions: Cushings syndrome, Metastases to central nervous system, Non-small cell lung cancer, Respiratory failure serious: 1 patientsex: 2 drugs: AZITHROMYCIN ANHYDROUS, HYDROXYCHLOROQUINE, PEA, PREDNISONE, TOCILIZUMAB reactions: Device reaction, Hypertransaminasaemia, Off label use serious: 1 patientsex: 1 drugs: ERGOCALCIFEROL, OLAPARIB, TALAZOPARIB reactions: Anaemia, Fatigue, Toxicity to various agents serious: 1 patientsex: 2 drugs: ATENOLOL, ETHAMBUTOL HYDROCHLORIDE, ISONIAZID, PYRAZINAMIDE, RIFAMPIN, TACROLIMUS reactions: Hepatic enzyme increased, Transaminases increased serious: 1 patientsex: 2 drugs: ANAKINRA, ASPIRIN, INFLIXIMAB, METHYLPREDNISOLONE reactions: Drug ineffective, Off label use serious: 1 patientsex: 2 drugs: FLUOXETINE HYDROCHLORIDE, DULOXETINE, METHIELDIME BLUE, ROPINIROLE reactions: Drug interaction, Serotonin syndrome serious: 1 patientsex: 1 drugs: FLUOROURACIL reactions: Cardiomyopathy serious: 1 patientsex: 2 drugs: CIPROFLOXACIN, LEVOFLOXACIN reactions: Drug ineffective, Maternal exposure during pregnancy, Pyelonephritis, Renal infarct serious: 1 patientsex: 2 drugs: ABACAVIR, ASPIRIN, BUDESONIDE, CYCLOPHOSPHAMIDE, CYTARABINE, CYTARABINE HYDROCHLORIDE, HYDROCORTISONE, HYDROXYCHLOROQUINE, METHYLPREDNISOLONE, METHYLPREDNISOLONE SODIUM SUCCINATE, METHYLPREDNISOLONE HYDROCHLORIDE, METHYLPREDNISOLONE SODIUM SUCCINATE, METHYLPREDNISOLONE SODIUM SUCCINATE, METHYLPREDNISOLONE SODIUM SUCCINATE, METHYLPREDNISOLONE SODIUM SUCCINATE, METHYLPREDNISOLONE SODIUM SUCCINATE, METHYLPREDNISOLONE SODIUM SUCCINATE, METHYLPREDNISOLONE SODIUM SUCCINATE, MET serious: 1 patientsex: 2 drugs: INSULIN ASPART, INSULIN DEGLUDEC, LANREOTIDE, VILDAGLIPTIN reactions: Hypoglycaemia serious: 1 patientsex: 2 drugs: ASPARAGINASE, DAUNORUBICIN, METHOTREXATE, VINCRISTINE reactions: Coagulopathy, Posterior reversible encephalopathy syndrome serious: 1 patientsex: 1 drugs: AZITHROMYCIN ANHYDROUS, DEXAMETHASONE, METHYLPREDNISOLONE, OSELTAMIVIR, PREDNISONE, VORICONAZOLE reactions: Blood glucose increased, Cough, Dyspnoea, Hypoxia, Mucormycosis, Pyrexia, Weight decreased serious: 1 patientsex: 1 drugs: DACLATASVIR, RIBAVIRIN, SOFOSBUVIR reactions: Hepatitis C serious: 1 patientsex: 1 drugs: LITHIUM, RISPERIDONE reactions: Hyperprolactinaemia serious: 1 patientsex: 2 drugs: METHYLPREDNISOLONE, MYCOPHENOLATE MOFETIL, PREDNISONE reactions: Histoplasmosis disseminated serious: 1 patientsex: 1 drugs: LEUPROLIDE ACETATE reactions: Injection site granuloma, Skin inflammation serious: 1 patientsex: 1 drugs: AVELUMAB reactions: Drug ineffective serious: 1 patientsex: 1 drugs: BLEOMYCIN SULFATE, CISPLATIN, ETOPOSIDE, FILGRASTIM, LEVOFLOXACIN, VANCOMYCIN reactions: Immune reconstitution inflammatory syndrome serious: 1 patientsex: 1 drugs: CALCIUM GLUCONATE, INSULIN NOS, POTASSIUM CHLORIDE, PIPERACILLIN SODIUMTAZOBACTAM SODIUM, SODIUM BICARBONATE, VASOPRESSIN reactions: Drug ineffective serious: 1 patientsex: 2 drugs: ALECTINIB, BRIGATINIB, LORAZEPAM reactions: Radiation necrosis serious: 1 patientsex: 1 drugs: MERCAPTOPURINE, INFLIXIMAB reactions: Pneumocystis jirovecii pneumonia serious: 1 patientsex: 2 drugs: CYCLOPHOSPHAMIDE, DASATINIB, NILOTINIB, RITUXIMAB reactions: Anaemia, Neutropenia, Thrombocytopenia serious: 1 patientsex: 1 drugs: ATORVASTATIN, CLONAZEPAM, LACOSAMIDE, LAMOTRIGINE, LEVETIRACETAM, PHENYTOIN, TRIAMTERENE, VALPROIC ACID reactions: Atrioventricular block first degree, Cardiac QRS complex prolonged, Conduction disorder, Electrocardiogram QRS complex prolonged, Electrocardiogram QRS complex prolonged, Electrocardiogram QRS complex prolonged, Electrocardiogram QRS complex prolonged, Left ventricular dysfunction, Ventricular tachycardia serious: 1 patientsex: 1 drugs: PREDNISONE reactions: Cushings syndrome serious: 1 patientsex: 1 drugs: ADEFOVIR DIPIVOXIL, LAMIVUDINE, TENOFOVIR ALAFENAMIDE, VALSARTAN reactions: Drug ineffective, Drug resistance, Hepatocellular carcinoma serious: 1 patientsex: 2 drugs: HYDROXYCHLOROQUINE, PREDNISONE reactions: Acute myocardial infarction, Ischaemic cardiomyopathy, Pericarditis serious: 1 patientsex: 1 drugs: DOCETAXEL, PREDNISOLONE reactions: Febrile neutropenia, Pulmonary embolism serious: 1 patientsex: 1 drugs: ALBUTEROL, PREDNISONE reactions: Osteonecrosis serious: 1 patientsex: 1 drugs: AMPHOTERICIN B, FLUCONAZOLE, VORICONAZOLE reactions: Drug ineffective serious: 1 patientsex: 1 drugs: CAPECITABINE, FLUOROURACIL, LEUCOVORIN, OXALIPLATIN reactions: Skin reaction serious: 1 patientsex: 2 drugs: BASILIXIMAB, CISATRACURIUM, FENTANYL, METHYLPREDNISOLONE, PROPOFOL reactions: Lactic acidosis serious: 1 patientsex: 1 drugs: CEFTRIAXONE, VANCOMYCIN reactions: Atypical infection, Drug ineffective, Osteomyelitis, Pneumonia pseudomonal, Septic shock serious: 1 patientsex: 1 drugs: DENOSUMAB, FLUOROURACIL, LEUCOVORIN, OXAPLATIN reactions: Decreased appetite, Diarrhoea serious: 1 patientsex: 2 drugs: HYDROXYUREA, THROMBOERECTIN reactions: Cellulitis, Eczema, Inflammatory syndrome, Palmar-plantar erythrodysaesthesia syndrome, Proteus infection, Skin atrophy, Skin ulcer, Thrombocytopenia serious: 1 patientsex: 2 drugs: DICLOFENAC, LEVOTHYROXINE, SODIUM PIGOSULFATEMAGNESIUM CITRATE reactions: Hyponatraemic encephalopathy serious: 1 patientsex: 2 drugs: PREDNISONE reactions: Lung abscess serious: 1 patientsex: 1 drugs: ATROPINE, MIDAZOLAM HYDROCHLORIDE reactions: Anaphylactic shock serious: 1 patientsex: 2 drugs: ISONIAZID, PYRIDOXINE reactions: Death, Neuropathy peripheral serious: 1 patientsex: 1 drugs: AMPICILLIN, LINEZOLID, PIPERACILLIN SODIUMTAZOBACTAM SODIUM, VANCOMYCIN reactions: Drug level increased, Renal impairment serious: 1 patientsex: 2 drugs: CLARITHROMYCIN reactions: Generalised tonic-clonic seizure serious: 1 patientsex: 2 drugs: CYCLOPHOSPHAMIDE, DOCETAXEL, DOXORUBICIN HYDROCHLORIDE reactions: Febrile neutropenia serious: 1 patientsex: 2 drugs: ATAZANAVIR, EVEROLIMUS, LAMIVUDINE, MYCOPHENOLIC ACID, PREDNISONE, RITONAVIR, ZIDOVUDINE reactions: Drug interaction, Oral ulcer, Perianal ulcer serious: 1 patientsex: 1 drugs: AZATHIOPRINE, PREDNISOLONE reactions: Drug ineffective serious: 1 patientsex: 2 drugs: ATORVASTATIN, CANDESARTAN, IPILIMUMAB, NIVOLUMAB, RABEPROZOLE reactions: Enteritis, Pneumonitis serious: 1 patientsex: 1 drugs: BEVACIZUMAB, FLUOROURACIL, IRINOTECAN, LEUCOVORIN, OXALIPLATIN, PANITUMUMAB reactions: Aspartate aminotransferase increased, Alanine aminotransferase increased, Hepatic function abnormal, Hepatic failure, Myodeopsia, Retinal haemorrhage, Thrombocytopenia serious: 1 patientsex: 2 drugs: FIDAXOMICIN, METRONIDAZOLE, VANCOMYCIN reactions: Colitis microscopic serious: 1 patientsex: 2 drugs: BELIMUMAB, CYCLOSPORINE, ZOLEDRONIC ACID reactions: Eye pain, Ocular hypersensitivity, Ocular adduction defect, Posterior vitreous detachment, Periorbital swelling, Periorbital oedema, Periorbital ptosis, Retinal oedema, Visual field defect serious: 1 patientsex: 1 drugs: REGORAFENIB reactions: Hypertension, Hypoalbuminaemia, Proteinuria, Renal impairment serious: 1 patientsex: 1 drugs: BLEOMYCIN SULFATE, DACARBAZINE, DOXORUBICIN, VINBLASTINE reactions: Cholestasis, Drug ineffective, Vanishing bile duct syndrome serious: 1 patientsex: 1 drugs: BORTEZOMIB, DEXAMETHASONE reactions: Neuropathy peripheral serious: 1 patientsex: 1 drugs: PREDNISONE reactions: Hepatitis B, Immunodeficiency, Off label use, Product use in unapproved indication, Tetanus serious: 1 patientsex: 1 drugs: ASPIRIN, CLOPIDOGREL BISULFATE reactions: Cytomegalovirus infection, Haematochezia, Pancytopenia, Pseudomonas infection serious: 1 patientsex: 2 drugs: METFORMIN HYDROCHLORIDE reactions: Acute kidney injury, Cobalt deficiency, Haemolytic anaemia, Haemolytic anaemia, Hypotension, Hypoxia, Menstrual bleeding, Pancytopenia, Schistocytosis, Sinus tachycardia serious: 1 patientsex: 2 drugs: BETAMETHASONE, AZATHIOPRINE, INSULIN ASPART, INSULIN HUMAN, INSULIN HUMAN, INSULIN HUMAN, INSULIN PREDNISOLONE, NAFAMOSTAT reactions: Drug ineffective, Drug resistance, Drug intolerance, Drug resistance, Drug resistance, Drug resistance, Drug intolerance, Drug resistance, Drug resistance, Drug intolerance, Drug resistance, Drug intolerance, Drug resistance, Drug intolerance, Drug resistance, Drug intolerance, Drug resistance, Drug intolerance, Drug resistance, Drug intolerance, Drug intolerance, Drug intolerance, Drug intolerance, Drug intolerance, Drug intolerance, Drug intolerance, Drug intolerance, Drug intolerance, Drug intolerance, Drug intolerance, Drug intolerance, Drug intolerance, Drug intolerance, Drug intolerance, Drug intolerance, Drug intolerance, Drug intolerance, Drug intolerance, Drug intolerance, Drug intolerance, Drug intolerance, Drug intolerance, Drug into serious: 1 patientsex: 1 drugs: PROPOFOL reactions: Propofol infusion syndrome serious: 1 patientsex: 2 drugs: CHLOROQUINE, IBUPROFEN, PREDNISOLONE reactions: Raccoon eye serious: 1 patientsex: 2 drugs: DABIGATRAN ETEXILATE MESYLATE reactions: Acute kidney injury, Asthenia, Haemoptysis, Overdose serious: 1 patientsex: 2 drugs: DULOXETINE reactions: Impulse-control disorder, Suicidal ideation serious: 1 patientsex: 1 drugs: ABIRATERONE ACETATE, PREDNISONE reactions: Cardiac failure congestive, Fluid retention serious: 1 patientsex: 2 drugs: FOLIC ACID, METHOTREXATE reactions: Myelosuppression, Mucosal inflammation, Toxicity to various agents serious: 1 patientsex: 2 drugs: ABACAVIR, EMTRICITABINETENOFOVIR DISOPROXIL FUMARATE, LAMIVUDINE, RILPIVIRINE reactions: Drug ineffective, Hepatic function abnormal serious: 1 patientsex: 2 drugs: AMPICILLIN, CEFTRIAXONE, RIVAROXABAN, PREDNISOLONE reactions: Aspergillus infection, Cardio-respiratory arrest, Drug ineffective, Haemoglobin decreased, Haemoglobin decreased, Haemoglobin decreased, Haemoglobin decreased, Intra-abdominal haematoma, Pericardial effusion, Pleural effusion, Pleural effusion, Splenic infarction, Splenic haematoma, Splenic infarction, Splenic haematoma, Splenic infarction, Splenic haematoma, Splenic infarction, Splenic haematoma, Splenic infarction, Splenic haematoma, Splenic infarction, Splenic haematoma, Splenic infarction, Splenic infarction, Splenic infarction, Splenic haematoma, Splenic infarction, Splenic infar serious: 1 patientsex: 2 drugs: BIPERIDEN HYDROCHLORIDE, CARBAMAZEPINE, CLOMIPRINE, CLOMIPRINE, CHLORPROMAZINE, INSULIN NOS, METFORMIN HYDROCHLORIDE, MIRTAZAPINE, VALPROIC ACID reactions: Circulatory collapse, Drug interaction, Lactic acidosis, Overdose, Suicide attempt serious: 1 patientsex: 2 drugs: AZATHIOPRINE, HYDROXYCHLOROQUINE, METHYLPREDNISOLONE reactions: Osteonecrosis serious: 1 patientsex: 2 drugs: CYCLOPHOSPHAMIDE, DOXORUBICIN, PREDNISOLONE, VINCRISTINE reactions: Anaemia, Asthenia, Blood pressure increased, Blood urea increased, Blood urea increased, Blood urea increased, Blood pressure systolic increased, Blood urea increased, Blood urea increased, Blood pressure systolic decreased, Blood urea increased, Blood pressure systolic increased, Blood urea increased, Blood urea increased, Blood pressure systolic decreased, Blood urea increased, Blood pressure systolic decreased, Blood urea increased, Blood pressure systolic decreased, Blood pressure systolic increased, Blood pressure systolic decreased, Blood pressure systolic increased, Blood pressure systolic decreased, Blood pressure systolic increased, Blood pressure systolic decreased, Blood pressure systolic increased, Blood pressure systolic decreased, Blood pressure sys serious: 1 patientsex: 2 drugs: LOSARTAN, METHYLPREDNISOLONE, TIMOLOL MALEATE, PROTONIX reactions: Interstitial lung disease serious: 1 patientsex: 1 drugs: METHOTREXATE, MYCOPHENOLATE MOFETIL, PREDNISONE reactions: Drug ineffective serious: 1 patientsex: 1 drugs: CIPROFLOXACIN, MYCOPHENOLIC ACID, PREDNISONE, TACROLIMUS reactions: Immune reconstitution inflammatory syndrome, Pneumonia klebsiella serious: 1 patientsex: 2 drugs: REGADENOSONE, ESTROGENS reactions: Electrocardiogram ST segment depression serious: 1 patientsex: 2 drugs: PEMBROLIZUMAB, PAZOPANIB reactions: Infusion related reaction, Hypothyroidism, Hypertension serious: 1 patientsex: 2 drugs: AZITHROMYCIN ANHYDROUS, CEFIXIME, MOXIFLOXACIN reactions: Enterocolitis bacterial, Staphylococcal infection serious: 2 patientsex: 2 drugs: HEPARIN SODIUM reactions: Foetal exposure during pregnancy serious: 1 patientsex: 1 drugs: ALTEPLASE reactions: Cerebral haemorrhage, Cerebral infarction serious: 1 patientsex: 2 drugs: BEVACIZUMAB, FLUOROURACIL, IRINOTECAN, LEUCOVORIN reactions: Hepatitis C, Metastases to spine, Metastases to lung, Metastases to spine, Pyrexia, Skin reaction serious: 1 patientsex: 1 drugs: CYCLOSPORINE, PREDNISONE, SULFASALAZINE reactions: Candida infection, Klebsiella infection, Polychondritis serious: 1 patientsex: 1 drugs: HYDROCORTISONE reactions: Drug ineffective, Periventricular leukomalacia serious: 1 patientsex: 1 drugs: CARBIMAZOLE, PREDNISONE, PYRIDOSTIGMINE reactions: Myasthenia gravis, Thyrotoxic crisis serious: 1 patientsex: 1 drugs: CARBOPLATIN, PEMETREXED reactions: Malignant neoplasm progression, Metastases to meninges serious: 1 patientsex: 2 drugs: SUNITINIB MALATE reactions: Ecchymosis, Leukopenia, Thrombocytopenia serious: 1 patientsex: 1 drugs: CLOPIDOGREL BISULFATE, HEPARIN SODIUM, NITROUS OXIDE, WARFARIN reactions: Aortic thrombosis, Cerebral infarction, Drug abuse, Dysarthria, Eye movement disorder, Paralysis, Pulmonary embolism, Paralysis serious: 1 patientsex: 2 drugs: PREGABALIN reactions: Anaemia, Leukopenia, Pyrexia, White blood cell count decreased, White blood cell count increased, Pyrexia, Pyrexia, White blood cell count increased, White blood cell count decreased, White blood cell count increased, White blood cell count decreased, White blood cell count increased, White blood cell count decreased, White blood cell count increased, White blood cell count decreased, White blood cell count increased, White blood cell count decreased, White blood cell count increased, White blood cell count decreased, White blood cell count increased, White blood cell count decreased, White blood cell count increased, White blood cell count decreased, White blood cell count increased, White blood cell count decreased, White blood cell count decreased, White blood cell count decreased, White blood cell count decreased, White blood cell count decreased, White blood cell count decreased, White blood cell count decreased, White blood cell count decreased, White blood cell count decreased, White blood cell count decreased, White blood cell count decreased, White blood cell count decreased, White blood cell count decreased, White blood cell count decreased, White blood cell count decreased, White blood cell count decreased, White blood cell count decreased, White blood cell serious: 1 patientsex: 1 drugs: CYCLOPHOSPHAMIDE, DOXORUBICIN, PREDNISOLONE, VINCRISTINE reactions: Diffuse large B-cell lymphoma serious: 1 patientsex: 1 drugs: DOCETAXEL, NINTEDANIB, RAMUCIRUMAB reactions: Anaemia, Decreased appetite, Gastric perforation, Pyrexia serious: 1 patientsex: 1 drugs: ALTEPLASE reactions: Ischaemic stroke serious: 1 patientsex: 1 drugs: CIPROFLOXACIN reactions: Drug ineffective serious: 1 patientsex: 2 drugs: ACETAMINOPHEN reactions: Hepatic encephalopathy, Overdose serious: 1 patientsex: 1 drugs: DAPTOMYCIN, GENTAMICIN, VANCOMYCIN reactions: Drug resistance serious: 1 patientsex: 2 drugs: BETAMETHASONE, IRBESARTAN, LABETALOLLABETALOL HYDROCHLORIDE reactions: Foetal exposure during pregnancy, Premature baby serious: 1 patientsex: 2 drugs: CARBOPLATIN, DEXAMETHASONE, FOLIC ACID, LEVOTHYROXINE, LORAZEPAM, OLANZAPINE, PANTOPRAZOLE SODIUM, ROSUVASTATIN, PROCHLORPERAZINE, PEMBROLIZUMAB, ROSUVASTATIN CALCIUM reactions: Tubulointerstitial nephritis serious: 1 patientsex: 1 drugs: SILDENAFIL reactions: Pulmonary arterial hypertension serious: 1 patientsex: 1 drugs: DOXORUBICIN HYDROCHLORIDE reactions: Disease progression serious: 1 patientsex: 1 drugs: CARFILZOMIB, DEXAMETHASONE, POMALIDOMIDE reactions: Burkholderia infection, Deep vein thrombosis, Meningitis bacterial, Pneumonia serious: 1 patientsex: 2 drugs: AZITHROMYCIN ANHYDROUS, AMOXICILLIN reactions: Foetal exposure during pregnancy, Low birth weight baby, Premature baby serious: 1 patientsex: 2 drugs: CIPROFLOXACIN, CEFEPIME HYDROCHLORIDE, GENTAMICIN, MEROPENEM reactions: Brain death, Seizure serious: 1 patientsex: 2 drugs: AMLODIPINE BESYLATE, BISOPROLOL, FUROSEMIDE, GLYMEPIRIDE, HEPARIN SODIUM, HYDROCORTISONE, MITOTANE, PIOGLITAZONE, SPIRONOLACTONE, TELMISARTAN, WARFARIN POTASSIUM reactions: Hepatic infarction, Intestinal ischaemia serious: 1 patientsex: 1 drugs: ASPIRIN, ATORVASTATIN, GLIPIZIDE, LEVOFLOXACIN, MOMETASONE, LOSARTAN, SPIRONOLACTONE, TORSEMIDE, WARFARIN reactions: Acute kidney injury, Hypoglycaemia, Hypokalaemia, Hypoglycaemia, Hypokalaemia, Hypokalaemia, Hypoglycaemia, Hypokalaemia, Hypokalaemia, Hypoglycaemia, Hypokalaemia, Hypoglycaemia, Hypokalaemia, Hypoglycaemia, Hypokalaemia, Hypokalaemia, Hypoglycaemia, Hypokalaemia, Hypokalaemia, Hypoglycaemia, Hypokalaemia, Hypokalaemia, Hypoglycaemia, Hypokalaemia, Hypokalaemia, Hypokalaemia, Hypoglycaemia, Hypokalaemia, Hypokalaemia, Hypokalaemia, Hypoglycaemia, Hypokalaemia, Hypokalaemia, Hypokalaemia, Hypoglycaemia, Hypokalaemia, serious: 1 patientsex: 1 drugs: MEROPENEM, VANCOMYCIN reactions: Cardiac tamponade, Pericardial effusion serious: 1 patientsex: 1 drugs: CYCLOSPORINE, PREDNISONE, WARFARIN reactions: Acute kidney injury, Drug interaction, Rhabdomyolysis serious: 1 patientsex: 2 drugs: EVEROLIMUS, LENVATINIB reactions: Drug ineffective serious: 1 patientsex: 1 drugs: FLUOROURACIL, LEUCOVORIN, OXALIPLATIN, PANITUMUMAB reactions: Neutropenia serious: 1 patientsex: 1 drugs: ALEMTUZUMAB, PREDNISONE, TACROLIMUS reactions: Autoimmune haemolytic anaemia, Enteritis, Fatigue, Jaundice, Leukopenia, Pancytopenia, Thrombocytopenia serious: 1 patientsex: 2 drugs: METHYLPREDNISOLONE, WARFARIN reactions: Adenocarcinoma metastatic, Cardiac arrest, Coagulopathy, Pulmonary embolism, Pneumothorax, Respiratory disorder, Thrombotic phenotype serious: 1 patientsex: 2 drugs: CAPTOPRIL reactions: Chondrosarcoma, Intraductal breast carcinoma serious: 1 patientsex: 1 drugs: BUSULFAN, FLUDARABINE PHOSPHATE, METHOTREXATE, TACROLIMUS reactions: Cytopenia serious: 1 patientsex: 1 drugs: CISPLATIN, CYCLOPHOSPHAMIDE, DOXORUBICIN, ETOPOSIDE, FLUOROURACIL, IFOSFAMIDE, PEGINTERAL GRANULocyte Colony stimulating factor, VINCRISTINE reactions: Candida infection, Febrile neutropenia serious: 1 patientsex: 1 drugs: FINASTERIDE reactions: Anxiety, Depression serious: 1 patientsex: 2 drugs: LAMIVUDINE, NEVIRAPINE, STAVUDINE reactions: Immune reconstitution inflammatory syndrome, Pulmonary tuberculosis serious: 1 patientsex: 2 drugs: CYCLOPHOSPHAMIDE, DOXORUBICIN, PREDNISOLONE, VINCRISTINE reactions: Disease recurrence serious: 1 patientsex: 2 drugs: CELECOXIB, FENTANYL, GABAPENTIN, MORPHINE, ROPIVACAINE HYDROCHLORIDE reactions: Vomiting serious: 1 patientsex: 1 drugs: CISPLATIN, ETOPOSIDE reactions: Anaemia, Appendicitis, Neutropenia, Thrombocytopenia serious: 1 patientsex: 1 drugs: ASPIRIN, CARVEDILOL, CAPTOPRIL, CLOPIDOGREL BISULFATE, PANTOPRAZOLE SODIUM, WARFARIN reactions: Drug-induced liver injury serious: 1 patientsex: 2 drugs: METHOTREXATE, PREDNISOLONE reactions: Hepatitis E, Epstein-Barr virus infection reactivation serious: 1 patientsex: 2 drugs: CRIZOTINIB reactions: Hepatitis fulminant serious: 1 patientsex: 1 drugs: EVEROLIMUS, METHYLPREDNISOLONE, MYCOPHENOLATE MOFETIL, PREDNISOLONE, TACROLIMUS reactions: Acute kidney injury, Cardiac arrest, Endocarditis fungal, Haemoperitoneum, Hypotension, Off label use, Sepsis, Pulmonary embolism, Transaminases increased serious: 1 patientsex: 2 drugs: METHOTREXATE reactions: Leishmaniasis serious: 1 patientsex: 2 drugs: BUSULFAN, CYCLOPHOSPHAMIDE, FLUDARABINE PHOSPHATE, IDARUBICIN, MYCOPHENOLATE MOFETIL, POSACONAZOLE, URSODIOL, TACROLIMUS, VALGANCICLOVIR reactions: Adenovirus hepatitis, Candida infection, Candida sepsis, Candida infection, Diarrhoea, Hepatitis fulminant, Nausea, Pancytopenia, Sepsis, Vomiting serious: 1 patientsex: 1 drugs: ACYCLOVIR, FLUDARABINE PHOSPHATE, GANCICLOVIR, MELPHALAN, METHOTREXATE, PREDNISONE, TACROLIMUS reactions: Enterococcal infection, Large intestine ileus serious: 1 patientsex: 1 drugs: ETHAMBUTOL HYDROCHLORIDE, ISONIAZID, PYRAZINAMIDE, RIFAMPIN reactions: Drug ineffective, Disseminated tuberculosis serious: 1 patientsex: 1 drugs: SILDENAFIL reactions: Drug interaction, Hepatic function abnormal, Overdose serious: 1 patientsex: 1 drugs: APIXABAN reactions: Hypersensitivity vasculitis serious: 1 patientsex: 2 drugs: CARBOPLATIN, GEMCITABINE reactions: Thrombotic microangiopathy serious: 1 patientsex: 2 drugs: CARVEDILOL, CINACALCET, MYCOPHENOLIC ACID, PREDNISOLONE, TACROLIMUS reactions: Interstitial lung disease, Pulmonary calcification serious: 1 patientsex: 1 drugs: WARFARIN reactions: Drug ineffective, Embolic stroke, International normalised ratio increased serious: 1 patientsex: 2 drugs: POLIDOCANOL reactions: Arterial embolism, Limb necrosis serious: 1 patientsex: 2 drugs: PATIROMER, SPIRONOLACTONE reactions: Hypomagnesaemia serious: 1 patientsex: 2 drugs: INFLIXIMAB reactions: Abdominal pain, Crohns disease, Diarrhoea, Diarrhoea serious: 1 patientsex: 2 drugs: BUPROPION, SERTRALINE HYDROCHLORIDE reactions: Reversible cerebral vasoconstriction syndrome serious: 1 patientsex: 1 drugs: DAPTOMYCIN, VANCOMYCIN reactions: Drug ineffective serious: 1 patientsex: 1 drugs: CLORAMBUCIL, INSULIN NOS reactions: Hyperglycaemia, Pulmonary embolism serious: 1 patientsex: 2 drugs: CETIRELIX ACETATE, FLUOXETINE HYDROCHLORIDE, LEVOTHYROXINE, MEGESTROL ACETATE reactions: Vaginal dehiscence serious: 1 patientsex: 1 drugs: ALBUTEROL, CEFTRIAXONE, OXYGEN reactions: Drug hypersensitivity serious: 1 patientsex: 2 drugs: ALBUTEROL, CYCLOSPORINE, DEMEROXIDE, FLUTAMINE, HUMAN IMMUNOGLOBULIN G, ISONIAZID, RIBAVIRIN, SPIRONOLACTONE, TAMIFLUM, ZOSYN MEDROL reactions: Acute respiratory distress syndrome, Pneumonitis viral, Respiratory failure serious: 1 patientsex: 1 drugs: AMLODIPINE BESYLATE, LACOSAMIDE, LEVETIRACETAM, LISINOPRIL reactions: Atrioventricular block, Bundle branch block left, Electrocardiogram PR prolongation, Electrocardiogram QRS complex prolonged, Sinus bradycardia, Sinus pause, Sinus tachycardia serious: 1 patientsex: 2 drugs: CALCIUM, FLUOROURACIL, OXALIPLATIN reactions: Pulmonary hypertension, Respiratory failure serious: 1 patientsex: 1 drugs: AMPHOTERICIN B, CEFTAZIDIME, LINEZOLID, LACTULOSE reactions: Drug ineffective, Nephropathy toxic serious: 1 patientsex: 2 drugs: GEMCITABINE reactions: Drug ineffective serious: 2 patientsex: 2 drugs: CARVEDILOL, ECULIZUMAB reactions: Foetal exposure during pregnancy, Low birth weight baby, Premature baby serious: 1 patientsex: 1 drugs: DOXORUBICIN HYDROCHLORIDE, IFOSFAMIDE reactions: Condition aggravated, Drug ineffective serious: 1 patientsex: 1 drugs: FENTANYL, KETAMINE, LEVETIRACETAM, MIDAZOLAM, PHENOBARBITAL, PROPOFOL, THIOPENTAL, VALPROIC ACID reactions: Drug ineffective, Status epilepticus serious: 1 patientsex: 2 drugs: LEVOTHYROXINE, PROPRANOLOL HYDROCHLORIDE, SERTRALINE HYDROCHLORIDE reactions: Accidental overdose, Loss of consciousness, Toxicity to various agents serious: 1 patientsex: 2 drugs: INSULIN NOS, MORPHINE reactions: Drug abuse, Splenic abscess serious: 1 patientsex: 2 drugs: MELPHALAN reactions: Disease progression, Toxicity to various agents serious: 1 patientsex: 1 drugs: AZITHROMYCIN ANHYDROUS, CEFEPIME HYDROCHLORIDE, HYDROXYCHLOROQUINE, LEVOFLOXACIN, MYCOPHENOLIC ACID, PREDNISONE, SULFAMETHOXAZOLETRIMETHOPRIM, TACROLIMUS reactions: Acute kidney injury, Drug ineffective, Hyperkalaemia, Oliguria, Renal impairment serious: 1 patientsex: 2 drugs: CALCIUM CARBONATE, COBICISTAT, EMTRICITABINETENOFOVIR ALAFENAMIDE, FLUOXETINE HYDROCHLORIDE, LAMIVUDINE, PYRIMETHAMINE, RALTEGRAVIR reactions: Drug interaction, Drug resistance, Gene mutation, Neutropenia serious: 1 patientsex: 2 drugs: AFATINIB reactions: Decreased appetite, Hypertension, Rash acneiform, Paralysis serious: 1 patientsex: 1 drugs: ASPARAGINASE, CYCLOPHOSPHAMIDE, CYTARABINE, DAUNORUBICIN, ETOPOSIDE, METHOTREXATE, VINCRISTINE reactions: Nail pigmentation serious: 1 patientsex: 1 drugs: CEFTRIAXONE, METRONIDAZOLE, PIPERACILLIN SODIUMTAZOBACTAM SODIUM reactions: Cardiac tamponade, Drug ineffective, Pericarditis, Septic shock serious: 1 patientsex: 1 drugs: LEVETIRACETAM, PREGABALIN reactions: Drug intolerance, Hepatic encephalopathy serious: 1 patientsex: 2 drugs: DACTINOMYCIN, ETOPOSIDE, IFOSFAMIDE, VINCRISTINE reactions: Abdominal pain, Constipation, Nausea, Vomiting serious: 1 patientsex: 1 drugs: CARBAMAZEPINE reactions: Skin eruption serious: 1 patientsex: 2 drugs: LITHIUM reactions: Hypercalcaemia, Neuropsychiatric symptoms serious: 1 patientsex: 2 drugs: OMEPRAZOLE, SUNITINIB MALATE, TRASTUZUMAB reactions: Immune thrombocytopenic purpura serious: 1 patientsex: 2 drugs: HYDROCORTISONE reactions: Adrenal hyperplasia, Hypertension, Hyperpyrexia, Sepsis serious: 1 patientsex: 1 drugs: WARFARIN reactions: Acute kidney injury, Haematoma, Rhabdomyolysis serious: 1 patientsex: 1 drugs: BUPIVACAINE, ASPIRIN, ATORVASTATIN, CARVEDILOL, GLYMEPIRIDE, IMIPRAZOLE, IPRATROPIUM BROMIDE, MEPERIDINE, THIAZIDE, VALSARTAN reactions: Drug interaction, Serotonin syndrome serious: 1 patientsex: 2 drugs: ATORVASTATIN, OMEPRAZOLE reactions: Acute kidney injury, Hypomagnesaemia, Torsade de pointes, Ventricular tachycardia serious: 1 patientsex: 1 drugs: GEMCITABINEGEMCITABINE HYDROCHLORIDE reactions: Urinary retention, Urinary tract infection, Thrombocytopenia serious: 1 patientsex: 2 drugs: ACYCLOVIR, AMLODIPINE BESYLATE, CLONAZEPAM, HYDROCHLOROTHIAZIDE, IRBESARTAN, FUROSEMIDE, HYDROCHLOROTHIAZIDE, METFORMIN HYDROCHLORIDE, MINOXIDE, PANTOPRAZOLE SODIUM, REPAGLINIDE, SPIRONOLACTONE reactions: Acute kidney injury, Drug interaction, Hypercalcaemia, Myoclonus, Renal impairment serious: 1 patientsex: 2 drugs: TOPIRAMATE reactions: Angle closure glaucoma, Pneumonia, Serous retinal detachment serious: 1 patientsex: 2 drugs: MAGNESIUM SULFATE reactions: Hypermagnesaemia, Nervous system disorder serious: 1 patientsex: 1 drugs: AMPHOTERICIN B, TERBINAFINE, VORICONAZOLE reactions: Drug ineffective serious: 1 patientsex: 1 drugs: AZATHIOPRINE, CYCLOSPORINE, PREDNISOLONE reactions: Condition aggravated, Drug ineffective serious: 1 patientsex: 2 drugs: DARUNAVIRRITONAVIR, RALTEGRAVIR reactions: Acute kidney injury, Drug resistance, Hypokalaemia, Proteinuria, Renal toxicity serious: 1 patientsex: 1 drugs: AZATHIOPRINE, MESALAMINE, METHYLPREDNISOLONE, PREDNISONE reactions: Colitis ulcerative, Hepatic function abnormal, Herpes simplex, Hepatitis disseminated, Hepatitis cirrhosis, Herpes simplex colitis, Hepatitis bacterial, Hepatitis viragenic, Hepatitis bacterial, Hepatitis cirrhosis, Hepatitis viragenic, Hepatitis bacterial, Herpes simplex hepatitis, Hepatitis viragenic, Hepatitis viragenic, Hepatitis viragenic, Hepatitis viragenic, Hepatitis viragenic, Hepatitis viragenic, Hepatitis viragenic, Hepatitis viragenic, Hepatitis viragenic, Hepatitis viragenic, Hepatitis viragenic, Hepatitis viragenic, Hepatitis serious: 1 patientsex: 2 drugs: AMPHOTERICIN B, SILDENAFIL, TACROLIMUS, WARFARIN reactions: Drug interaction, Sporotrichosis serious: 1 patientsex: 2 drugs: HYDROXYCHLOROQUINE, METRONIDAZOLE, PREDNISONE reactions: Hepatitis herpes simplex serious: 1 patientsex: 2 drugs: LEVODPA, OXYCODONE, PREGABALIN, ROTIGOTINE reactions: Dizziness, Nausea, Vomiting serious: 1 patientsex: 1 drugs: CLONAZEPAM, LORAZEPAM, METRONIDAZOLE, OLANZAPINE, VALPROIC ACID reactions: Condition aggravated, Drug ineffective, Off label use serious: 1 patientsex: 2 drugs: CISPLATIN, DEXAMETHASONE, FLUOROURACIL, LEUCOVORIN, OXALIPLATIN, VINORELBINE TARTRATE reactions: Acute coronary syndrome, Coagulopathy, Pericardial effusion, Osteonecrosis serious: 1 patientsex: 1 drugs: DOXYCYCLINE, RIVAROXABAN reactions: Cerebral artery thrombosis, Drug ineffective serious: 1 patientsex: 2 drugs: CYCLOPHOSPHAMIDE, DOCETAXEL, DOXORUBICIN, TRASTUZUMAB reactions: Acute respiratory distress syndrome serious: 1 patientsex: 1 drugs: CIPROFLOXACIN, ECULIZUMAB, METHYLPREDNISOLONE, METHYLPREDNISOLONE SODIUM SUCCINATE, METHYLPREDNISOLONE ACETATE, METHYLPREDNISOLONE SODIUM SUCCINATE, METHYLPREDNISOLONE SODIUM SUCCINATE, METHYLPREDNISOLONE ACETATE, METHYLPREDNISOLONE SODIUM SUCCINATE, METHYLPREDNISOLONE SODIUM SUCCINATE, METHYLPREDNISOLONE SODIUM SUCCINATE, METHYLPREDNISOLONE SODIUM SUCCINATE, METHYLPREDNISOLONE SODIUM SUCCINATE, METHYLPREDNISOLONE SODIUM SUCCINATE, METHYLPREDNISOLONE SODIUM SUCCINATE, MET serious: 1 patientsex: 2 drugs: AZATHIOPRINE, CYCLOSPORINE, HYDROXYCHLOROQUINE, METHOTREXATE, MYCOPHENOLATE MOFETIL, PREDNISONE reactions: Acne, Dizziness, Staphylococcal infection serious: 1 patientsex: 1 drugs: BEVACIZUMAB, DOCETAXEL, GEMCITABINEGEMCITABINE HYDROCHLORIDE reactions: Proteinuria serious: 1 patientsex: 2 drugs: CYCLOPHOSPHAMIDE, CYTARABINE, DOXORUBICIN, HYDROCORTISONE, METHOTREXATE, PREDNISOLONE, RITUXIMAB, VINCRISTINE reactions: Abdominal compartment syndrome, Febrile neutropenia, Sepsis serious: 1 patientsex: 2 drugs: METHOTREXATE reactions: Autoimmune hepatitis serious: 1 patientsex: 2 drugs: ALPRAM, DICLOFENAC, FROVATRITAN, MILANACIPRAN, OXYCODONE, PREGABALIN reactions: Drug ineffective serious: 1 patientsex: 1 drugs: IPILIMUMAB, NIVOLUMAB, PREDNISONE reactions: Cataract nuclear, Conjunctival hyperaemia, Eye irritation, Iridocyclitis, Iridocyclitis granulomatous, Iridocyclitis, Iridocyclitis serious: 1 patientsex: 1 drugs: METHYLPREDNISOLONE, MYCOPHENOLATE MOFETIL, PREDNISOLONE, TACROLIMUS, VALGANCICLOVIR reactions: Cytomegalovirus infection, Gastrointestinal toxicity serious: 1 patientsex: 2 drugs: IOHEXOL reactions: Generalised tonic-clonic seizure serious: 1 patientsex: 2 drugs: DULOXETINE, PREGABALIN, TRAMADOL reactions: Drug ineffective serious: 1 patientsex: 1 drugs: CISPLATIN, DOXORUBICIN, METHOTREXATE reactions: Status epilepticus serious: 1 patientsex: 2 drugs: IMATINIB MESYLATE reactions: Drug ineffective, Drug tolerance serious: 1 patientsex: 2 drugs: CEFUROXIME reactions: Arthritis reactive, Clostridium difficile colitis serious: 1 patientsex: 2 drugs: CARBOPLATIN, DOXORUBICIN, ETOPOSIDE, MITOTANE reactions: Febrile neutropenia, Pancreatic pseudocysts, Recurrent cancer serious: 1 patientsex: 1 drugs: ASPIRIN, CLOPIDOGREL BISULFATE reactions: Haemorrhagic transformation stroke serious: 1 patientsex: 2 drugs: AMOXICILLINCLAVULANIC ACID reactions: Blindness transient, Encephalopathy, Hypoglycaemia, Hyponatraemia, Rash maculo-papular serious: 1 patientsex: 1 drugs: LEDIPASVIRSOFOSBUVIR, ROMIPLOSTIM reactions: Asthenia, Encephalopathy, Leishmaniasis, Pyrexia, Thrombocytopenia serious: 1 patientsex: 1 drugs: BORTEZOMIB, CYCLOPHOSPHAMIDE, DOXORUBICIN, ETOPOSIDE, METFORMIN HYDROCHLORIDE, RAMIPRIL, PREDNISOLONE, VINCRISTINE reactions: Neuropathy peripheral serious: 1 patientsex: 1 drugs: AMLODIPINE BESYLATE, ASPIRIN, ATORVASTATIN, CLOPIDOGREL BISULFATE, METOPROLOL, OMEPRAZOLE reactions: Cholestasis, Drug ineffective, Haemoglobin decreased, Haemoglobin increased, Haemoglobin decreased, Haemoglobin increased, Haemoglobin decreased, Haemoglobin increased, Leiomyoma, OMEPRAZOLE reactions: Haemoglobin decreased, Renal impairment serious: 1 patientsex: 1 drugs: PEMBROLIZUMAB reactions: Off label use, Product use in unapproved indication serious: 1 patientsex: 2 drugs: EFAVIRENZ, LAMIVUDINE, TENOFOVIR DISOPROXIL FUMARATE reactions: Cytomegalovirus infection, Hydrocephalus, Meningoencephalitis cytomegalovirus, Pneumocystis jirovecii infection serious: 1 patientsex: 2 drugs: CISPLATIN, FLUOROURACIL reactions: Cardiogenic shock serious: 1 patientsex: 1 drugs: CARBOPLATIN, DOCETAXEL, GEMCITABINEGEMCITABINE HYDROCHLORIDE reactions: Drug ineffective serious: 1 patientsex: 1 drugs: AMIODARONE HYDROCHLORIDE reactions: Torsade de pointes serious: 1 patientsex: 1 drugs: HYDROXYUREA, PREDNISOLONE, RUXOLITINIB reactions: Disseminated tuberculosis serious: 1 patientsex: 1 drugs: CYCLOSPORINE, METHYLPREDNISOLONE, PREDNISOLONE reactions: Aspergillus infection, Fusarium infection, Pulmonary aspergillosis, Sepsis serious: 1 patientsex: 1 drugs: ACYCLOVIR reactions: Acute kidney injury, Thrombotic microangiopathy serious: 1 patientsex: 1 drugs: IDELALISIB reactions: Dermatitis exfoliative, Off label use, Respiratory failure, Septic shock serious: 1 patientsex: 2 drugs: LACOSAMIDE, LEVETIRACETAM, PHENOBARBITAL, PHENYTOIN, VALPROIC ACID reactions: Bradycardia, Hypotension, Sinus node arrest, Toxicity to various agents serious: 1 patientsex: 1 drugs: METHIMAZOLE, METOPROLOL reactions: Exposure during pregnancy, Pre-eclampsia, Respiratory distress syndrome serious: 1 patientsex: 1 drugs: AMIKACIN, AMOXICILLIN, HYDROCORTISONE reactions: Aspergillus infection, Exposure during pregnancy, Premature baby serious: 1 patientsex: 2 drugs: BASILIXIMAB, MYCOPHENOLATE MOFETIL, PREDNISOLONE, TACROLIMUS, VALGANCICLOVIR reactions: Anaemia autoimmune, Epstein-Barr virus infection, Iron overload, Iron overload serious: 1 patientsex: 2 drugs: GENTAMICIN reactions: Dizziness, Ocular hyperaemia, Oscillation, Ocular dysfunction, Ocular dysfunction serious: 1 patientsex: 2 drugs: ALECTINIB, CODEIN PHOSPHATE, METHYLPREDNISOLONE, PREDNISOLONE reactions: Glomerulonephritis rapidly progressive, Pancreatitis serious: 1 patientsex: 2 drugs: CYTARABINE, FLUDARABINE PHOSPHATE, FILGRASTIM reactions: Febrile neutropenia, Urinary tract infection serious: 1 patientsex: 2 drugs: ACETAMINOPHENCODEINE PHOSPHATE, CARBAMAZEPINE, GABAPENTIN reactions: Anxiety, Dizziness, Drug ineffective, Tremor serious: 1 patientsex: 1 drugs: TALATE reactions: Anaphylactic reaction, Drug ineffective, Gingival bleeding, Haematemesis, Melaena, Oral eruption, Treatment failure serious: 1 patientsex: 2 drugs: PALONOSETRON reactions: Vomiting serious: 1 patientsex: 2 drugs: METHOTREXATE, TOCILIZUMAB reactions: Pneumonia aspiration, Systemic inflammatory response syndrome serious: 1 patientsex: 2 drugs: CAPECITABINE, DASATINIB, PACLITAXEL, VINORELBINEVINORELBINE TARTRATE reactions: Diarrhoea, Neutropenia serious: 1 patientsex: 1 drugs: ADENOSINE, AMIODARONE, SOTALOL reactions: Drug hypersecretion serious: 1 patientsex: 2 drugs: BASILIXIMAB, EPOPROSTENOL, METHYLPREDNISOLONE, MYCOPHENOLATE MOFETIL, PREDNISONE, SILDENAFIL, TACROLIMUS, WARFARIN reactions: Acute kidney injury, Shock haemorrhagic serious: 1 patientsex: 1 drugs: VALPROIC ACID reactions: Kaposis sarcoma serious: 1 patientsex: 1 drugs: AMLODIPINE BESYLATE, CALCITRIOL, CINACALCET, FUROSEMIDE, HEPARIN SODIUM, LOSARTAN, METFORMIN HYDROCHLORIDE, ZOLEDRONIC ACID reactions: Hypercortisolism, Stress serious: 1 patientsex: 1 drugs: AMOXICILLINCLAVULANATE POTASSIUM reactions: Agranulocytosis, Febrile neutropenia serious: 1 patientsex: 2 drugs: ACETAZOLAMIDE, LACOSAMIDE, LAMOTRIGINE, LEVETIRACETAM, TOPIRAMATE reactions: Drug ineffective, Myoclonus serious: 2 patientsex: 2 drugs: ACETAMINOPHEN, BUPIVACAINE HYDROCHLORIDE, EPINEPHRINE, IBUPROFEN, MORPHINE, OXYCODONE reactions: Respiratory arrest serious: 1 patientsex: 2 drugs: ETHAMBUTOL HYDROCHLORIDE, ISONIAZID, MEROPENEM, MOXIFLOXACIN, PYRAZINAMIDE, RIFAMPIN, VORICONAZOLE reactions: Drug ineffective serious: 1 patientsex: 1 drugs: ASPIRIN, DIPYRIDAMOLE reactions: Shock, Splenic rupture serious: 1 patientsex: 2 drugs: EVEROLIMUS reactions: Off label use serious: 1 patientsex: 2 drugs: PEGINTERFERON ALFA-2B, RIBAVIRIN reactions: Retinopathy, Visual impairment serious: 1 patientsex: 1 drugs: TETRACAINE HYDROCHLORIDE reactions: Corneal decompensation, Punctate epithelial keratitis serious: 1 patientsex: 1 drugs: ABACAVIR, AMPHOTERICIN B, CYCLOPHOSPHAMIDE, ENFUVIR, LAMIVUDINE, MELPHALAN, METHYLPREDNISOLONE, METHYLPREDNISOLONE SODIUM SUCCINATE, METHYLPREDNISOLONE ACETATE, METHYLPREDNISOLONE SODIUM SUCCINATE, METHYLPREDNISOLONE ACETATE, MELPHALAN, METHYLPREDNISOLONE SODIUM SUCCINATE, METHYLPREDNISOLONE SODIUM SUCCINATE, METHYLPREDNISOLONE SODIUM SUCCINATE, METHYLPREDNISOLONE SODIUM SUCCINATE, METHYLPREDNISOLONE SODIUM SUCCINATE, METHYLPREDNISOLONE SODIUM SUCCINATE, METHYLPREDNISOLONE SODIUM serious: 1 patientsex: 1 drugs: ASPIRIN, ATORVASTATIN, INSULIN NOS, METOPROLOL, LISINOPRIL reactions: Immune-mediated necrotising myopathy serious: 1 patientsex: 1 drugs: DOXORUBICIN, METHOTREXATE, VINCRISTINE reactions: Pancytopenia, Neutropenia, Pneumonia, Pneumonia pulmonary serious: 1 patientsex: 2 drugs: BUPROPION HYDROCHLORIDE, TRAZODONE HYDROCHLORIDE reactions: Agitation, Agitation, Intentional overdose, Leukocytosis, Mental disorder, Overdose, Seizure serious: 1 patientsex: 2 drugs: LITHIUM reactions: Hypercalcaemia, Hyperparathyroidism serious: 1 patientsex: 1 drugs: BASILIXIMAB, MYCOPHENOLATE MOFETIL, PREDNISONE, TACROLIMUS reactions: Anaemia, Anaemia cytomegaloviral, Anasarca, Anaemia, Anaemia recurrent, Anaemia, Anaemia, Anaemia, Anaemia, Anaemia, Anaemia, Anaemia, Anaemia, Anaemia, Anaemia, Anaemia, Anaemia, Anaemia, Anaemia, Anaemia, Anaemia, Anaemia, Anaemia, Anaemia, Anaemia, Anaemia, Anaemia, Anaemia, Anaemia, Anaemia, Anaemia, Anaemia, Anaemia, Anaemia, Anaemia, Anaemia, Anaemia, Anaemia, Anaemia, Anaemia, Anaemia, Anaemia, Anaemia, Anaemia, Anaemia, Anaemia, Anaemia, Anaemia, Anaemia, Anaemia, Anaemia, Anaemia, Anaemia, Anaemia, Anaemia, Anaemia, Anaemia, Anaemia, Anaemia, Anaemia, Anaemia, Anaemia, Anaemia, Anaemia, Anaemia, Anaemia, Anaemia, Anaemia, serious: 1 patientsex: 1 drugs: DACLIZUMAB, NIVOLUMAB reactions: Drug reaction with eosinophilia and systemic symptoms serious: 1 patientsex: 1 drugs: EPINEPHRINE, LIDOCAINE, SIMVASTATIN reactions: Ocular oedema serious: 1 patientsex: 2 drugs: CISPLATIN, FLUOROURACIL reactions: Pancytopenia, Thrombocytopenia serious: 1 patientsex: 1 drugs: OXALIPLATIN, PACLITAXEL, XELODA reactions: Fatigue, Hepatic function abnormal, Urinary tract infection fungal, Urinary tract infection bacterial serious: 1 patientsex: 1 drugs: METHAMPHETAMINE, NICOTINE, MIRTAZAPINE, RISPERIDONE reactions: Drug abuse, Head movement disorder serious: 1 patientsex: 1 drugs: ETHAMBUTOL HYDROCHLORIDE, ISONIAZID, RIFAMPIN reactions: Fanconi syndrome acquired, Paralysis serious: 1 patientsex: 2 drugs: HEPARIN SODIUM, PHENYLEPHRINE HYDROCHLORIDE reactions: Abdominal compartment syndrome, Acute kidney injury, Haemoglobin decreased, Retroperitoneal haematoma serious: 1 patientsex: 1 drugs: BORTEZOMIB, DEXAMETHASONE, LENALIDOMIDE reactions: Pneumonia serious: 1 patientsex: 2 drugs: CEFTRIAXONE, VANCOMYCIN reactions: Drug ineffective, Pneumonia bacterial serious: 1 patientsex: 1 drugs: BEVACIZUMAB, CARBOPLATIN, PACLITAXEL reactions: Fatigue, Neuropathy peripheral, Toxicity to various agents serious: 1 patientsex: 1 drugs: TAMSULOSIN HYDROCHLORIDE reactions: Aortitis, Biliary dilatation, Biliary mass, Biliary tract disorder, Biliary tract disorder, Biliary mass, Biliary tract disorder, Biliary tract disorder, Biliary mass, Biliary tract disorder, Biliary tract disorder, Biliary mass, Biliary tract disorder, Biliary tract disorder, Biliary mass, Biliary tract disorder, Biliary tract disorder, Biliary tract disorder, Biliary tract disorder, Biliary tract disorder, Biliary tract disorder, Biliary tract disorder, Biliary tract disorder, Biliary tract disorder, Biliary tract disorder, Biliary tract disorder, Biliary tract disorder, Biliary tract disorder, Biliary tract disorder, Biliary tract disorder, Biliary tract disorder, Biliary tract disorder, Biliary tract disorder, Biliary tract disorder, Biliary tract disorder, Biliary tract disorder, Biliary tract disorder, Biliary tract disorder, Biliary tract disorder, Biliary serious: 1 patientsex: 2 drugs: CYCLOPHOSPHAMIDE, METHYLPREDNISOLONE, MYCOPHENOLATE MOFETIL, RITUXIMAB, TACROLIMUS reactions: Drug ineffective serious: 1 patientsex: 1 drugs: ACETAMINOPHENOXYCODONE HYDROCHLORIDE, BUPROPION HYDROCHLORIDE reactions: Drug-induced liver injury serious: 1 patientsex: 1 drugs: ADEFOVIR DIPIVOXIL, ENTECAVIR, LAMIVUDINE reactions: Drug resistance serious: 1 patientsex: 2 drugs: LAMOTRIGINE reactions: Exposure during pregnancy serious: 1 patientsex: 1 drugs: ADENOSINE, FLECAINIDE, PROTAFENONE reactions: Anaphylactic reaction, Hypotension serious: 1 patientsex: 2 drugs: ASPIRIN, RIVAROXABAN reactions: Carotid artery aneurysm serious: 1 patientsex: 1 drugs: FLUOROURACIL, LEUCOVORIN, OXALIPLATIN reactions: Drug ineffective serious: 1 patientsex: 1 drugs: ADALIMUMAB, ETANERCEPT, CYCLOSPORINE, INFLIXIMAB, METHOTREXATE reactions: Drug ineffective, Drug resistance serious: 1 patientsex: 2 drugs: CLONAZEPAM, LEVETIRACETAM, VALPROIC ACID reactions: Drug ineffective, Thrombocytopenia serious: 1 patientsex: 1 drugs: ALLOPURINOL, HYDROXYUREA reactions: Acute myeloid leukaemia, Drug resistance serious: 1 patientsex: 2 drugs: METHOTREXATE, METHYLPREDNISOLONE, PREDNISOLONE, VINNORELBINEVINNORELBINE TARTRATE reactions: Drug ineffective serious: 1 patientsex: 2 drugs: METHYLENE BLUE reactions: Drug ineffective serious: 1 patientsex: 1 drugs: AZITHROMYCIN ANHYDROUS, CEFTRIAXONE, VANCOMYCIN reactions: Dermatomyositis, Stevens-Johnson syndrome serious: 1 patientsex: 1 drugs: ACETAMINOPHEN, FENTANYL, HYDROMORPHONE, IBUPROFEN, MORPHINE SULFATE reactions: Duodenal ulcer haemorrhage serious: 1 patientsex: 1 drugs: BUSULFAN, FLUDARABINE PHOSPHATE, MELPHALAN, TACROLIMUS reactions: Bacteraemia, Alveolar haemorrhage, Pneumonia, Toxicity to various agents serious: 1 patientsex: 2 drugs: AMIODARONE, EPINEPHRINE reactions: Drug ineffective, Haemoglobin decreased, Off label use, Ventricular fibrillation serious: 1 patientsex: 2 drugs: AMOXICILLIN, CEFIXIME, CLINDAMYCIN reactions: Stevens-Johnson syndrome serious: 1 patientsex: 1 drugs: CABERGOLINE reactions: Pneumocephalus serious: 1 patientsex: 2 drugs: BLEOMYCIN SULFATE, DACARBAZINE, DOXORUBICIN, VINBLASTINE reactions: Disease recurrence serious: 1 patientsex: 2 drugs: CYTARABINE, IDARUBICIN, TRETINOIN reactions: Haemorrhage serious: 1 patientsex: 2 drugs: CYCLOSPORINE, ETOPOSIDE, PREDNISOLONE, VINCRISTINE reactions: Leukopenia, Neutropenia serious: 1 patientsex: 2 drugs: AMOXICILLINCLAVULANIC ACID, AMPICILLIN SODIUMSULBACTAM SODIUM, CIPROFLOXACIN, COLISTIN, CIPROFLOXACIN HYDROCHLORIDE, GLIMEPIRIDE, IMIPENEM, INSULIN NOS, METHYLPREDNISOLONE, MYCOPHENOLATE MOFETIL, PREDNISONE, TACROLIMUS, VALGANCICLOVIR reactions: Acinetobacter infection, Candida infection, Candida infection, Candida infection, Candida infection, Candida infection, Candida infection, Candida infection, Candida infection, Candida infection, Candida infection, Candida infection, Candida infection, Candida infection, Candida infection, Candida infection, Candida infection, Candida infection, Candida infection, Candida infection, Candida infection, Candida infection, Candida infection, Candida infection, Candida infection, Candida infection, Candida infection, Candida infection, Candida infection, Candida infection, Candida infection, Candida infection, Candida infection, Candida infection, Candida infection, Candida infection, Candida infection, Candida infection, Candida infection, Candida infection serious: 1 patientsex: 1 drugs: CYTARABINE, DAUNORUBICIN, FLUDARABINE PHOSPHATE, RASBURICASE reactions: Drug ineffective serious: 1 patientsex: 1 drugs: IRINOTECAN reactions: Pancytopenia, Superior vena cava syndrome serious: 1 patientsex: 1 drugs: LOPERAMIDE HYDROCHLORIDE reactions: Acute kidney injury, Cardiac arrest, Drug abuse, Overdose, Ventricular tachycardia serious: 1 patientsex: 2 drugs: ASPIRIN, CARVEDILOL, EZETIMIBE, INSULIN DETEMIR, LINAGLIPTIN, LOSARTAN, ROSUVASTATIN CALCIUM, TICAGRELOR reactions: Acute kidney injury, Drug interaction, Rhabdomyolysis serious: 1 patientsex: 1 drugs: DICHENHYDRAMINE, HYDROCORTISONE, PREDNISONE, VANCOMYCIN reactions: Drug reaction, Emotional distress, Rash, Treatment noncompliance serious: 1 patientsex: 1 drugs: ETHAMBUTOL HYDROCHLORIDE, ISONIAZID, PYRAZINAMIDE, RIFAMPIN reactions: Gynaecomastia serious: 1 patientsex: 1 drugs: Activated charcoal, NICALIPINE, SODIUM POLYSTYRENE SULFONATE, SERTRALINE HYDROCHLORIDE, ZALEPLON reactions: Intentional overdose, Pneumatosis intestinalis, Suicide attempt serious: 1 patientsex: 2 drugs: EFAVIRENZ, EMTRICITABINE, FLUCONAZOLE, GANCICLOVIR, SULFAMETHOXAZOLETRIMETHOPRIM, TENOFOVIR reactions: Acute kidney injury, Drug interaction, Metabolic acidosis, Nephropathy toxic, Renal impairment serious: 1 patientsex: 1 drugs: AMIKACIN, CYCLOPHOSPHAMIDE, FLUDARABINE PHOSPHATE, MEROPENEM, PREDNISONE reactions: Septic shock serious: 1 patientsex: 2 drugs: CYCLOPHOSPHAMIDE, DOXORUBICIN, FLUOROURACIL, METFORMIN HYDROCHLORIDE, TAMOXIFEN reactions: Hypertriglyceridaemia, Pancreatitis acute serious: 1 patientsex: 1 drugs: ANAKINRA, CANAKINUMAB, METHOTREXATE reactions: Drug intolerance, Rheumatoid arthritis serious: 1 patientsex: 1 drugs: EFAVIRENZ, ETHAMBUTOL HYDROCHLORIDE, ISONIAZID, LEVOFLOXACIN, PYRAZINAMIDE, RIFAMPIN, SULFAMETHOXAZOLETRIMETHOPRIM, TENOFOVIR DISOPROXIL FUMARATE reactions: Acute kidney injury, Fungal infection, Pneumocystis jirovecii pneumonia serious: 1 patientsex: 1 drugs: ACYCLOVIR, CEFTRIAXONE, FLUCONAZOLE, METHOTREXATE, METOPROLOL, URSODIOL, SIROLIMUS, TACROLIMUS reactions: Abdominal pain upper, Bone pain, Duodenitis, Dysphagia, Oesophageal sphincter disorder, Muscle pain, Oesophageal pain, Oesophageal sphincter spasms, Oesophageal sphincter disorder, Oesophageal sphincter disorder, Oesophageal reflux disease, Oesophageal sphincter disorder, Oesophageal sphincter disorder, Oesophageal sphincter disorder, Oesophageal sphincter stenosis, Oesophageal reflux disease, Oesophageal sphincter stenosis, Oesophageal sphincter steno serious: 1 patientsex: 2 drugs: ALBUTEROL, ATROPINE, BUDESONIDE, FLUTICASONE PROPIONATESALMETEROL XINAFOATE, IPRATROPIUM BROMIDEOXYGEN, TIOTROPIUM BROMIDE reactions: Chest pain, Electrocardiogram ST segment elevation, Drug interaction serious: 1 patientsex: 2 drugs: CLOBAZAM, DEXAMETHASONE, LAMOTRIGINE, LEVETIRACETAM, METOCLOPRAMIDE, RANITIDINE, SEVOFLURANE, THIOPENTAL reactions: Foetal exposure during pregnancy, Premature baby serious: 1 patientsex: 1 drugs: VORICONAZOLE reactions: Aspergillus infection, Febrile neutropenia serious: 1 patientsex: 1 drugs: NIMESULIDE reactions: Drug ineffective serious: 1 patientsex: 1 drugs: BORTEZOMIB, CYCLOPHOSPHAMIDE, DEXAMETHASONE reactions: Death serious: 1 patientsex: 1 drugs: CAPECITABINE, OXALIPLATIN reactions: Hepatic fibrosis, Hepatic sinusoidal obstruction syndrome, Peliosis, Sinusoidal obstruction serious: 1 patientsex: 2 drugs: AMLODIPINE BESYLATE, ENALAPRIL, LAMIVUDINE, MYCOPHENOLATE MOFETIL, PREDNISOLONE, TACROLIMUS, VALSARTAN reactions: Aortic stenosis, Vasculitis serious: 1 patientsex: 1 drugs: ALLOPURINOL, CARBOPLATIN, GEMCITABINEGEMCITABINE HYDROCHLORIDE reactions: Drug ineffective serious: 1 patientsex: 1 drugs: LIDOCAINE reactions: Anaphylactic reaction, Drug hypersensitivity serious: 1 patientsex: 2 drugs: LEVETIRACETAM reactions: Drug ineffective serious: 2 patientsex: 2 drugs: ASPIRIN reactions: Foetal exposure during pregnancy, Low birth weight baby, Premature baby serious: 1 patientsex: 1 drugs: ACYCLOVIR, DEXAMETHASONE, METHYLPREDNISOLONE reactions: Drug ineffective serious: 1 patientsex: 1 drugs: CYTARABINE, DOXORUBICIN HYDROCHLORIDE, PREDNISOLONE, RITUXIMAB, VINCRISTINE reactions: Acute lymphocytic leukaemia recurrent, Cardiac arrest, Febrile neutropenia, Respiratory arrest serious: 1 patientsex: 1 drugs: CYCLOPHOSPHAMIDE, METHOTREXATE, RITUXIMAB reactions: Drug ineffective, Off label use serious: 1 patientsex: 1 drugs: LEVETIRACETAM, OMEPRAZOLE, LISINOPRIL, VALPROIC ACID reactions: Cerebral ischaemia, Cerebral interstitial nephritis serious: 1 patientsex: 2 drugs: ADALIMUMAB, CYCLOSPORINE, INFLIXIMAB, METHOTREXATE, USTEKINUMAB reactions: Treatment failure serious: 1 patientsex: 1 drugs: FLUCONAZOLE, GENTAMICIN, IMIPENEM, TAZOCIN reactions: Drug ineffective serious: 1 patientsex: 2 drugs: CYCLOPHOSPHAMIDE, DOXORUBICIN, PREDNISOLONE, RITUXIMAB, VINCRISTINE reactions: Intestinal perforation serious: 1 patientsex: 1 drugs: BEVACIZUMAB, FLUOROURACIL, IRINOTECAN, LEUCOVORIN, OXALIPLATIN reactions: Acute kidney injury, Febrile neutropenia, Haemoglobin decreased, Leukopenia, Neutrophil count decreased, Thrombocytopenia serious: 1 patientsex: 2 drugs: CYCLOPHOSPHAMIDE, DOXORUBICIN, RITUXIMAB reactions: Pulmonary embolism serious: 1 patientsex: 1 drugs: HYDROCORTISONE reactions: Atrioventricular block complete, Ventricular fibrillation, Ventricular tachycardia serious: 1 patientsex: 2 drugs: CAPECITABINE, DACARBAZINE, MITOTANE reactions: Adrenocortical cancer metastatic, Malignant neoplasm progression serious: 1 patientsex: 1 drugs: LEVETIRACETAM reactions: Drug intolerance, Epilepsy serious: 1 patientsex: 2 drugs: NITROFURANTOIN reactions: Chest pain, Dyspnoea, Pulmonary effusion serious: 1 patientsex: 2 drugs: ATORVASTATIN, CANAGLIFLOZIN, LISINOPRIL reactions: Candida infection, Febrile neutropenia, Klebsiella infection, Pyelonephritis, Sepsis serious: 1 patientsex: 1 drugs: AMOXICILLINCLAVULANIC ACID, CLARITHROMYCIN, LEVOFLOXACIN, METHYLPREDNISOLONE, PIPERACILLIN SODIUMTAZOBACTAM SODIUM, RIFAMPIN reactions: Eosinophilic pneumonia acute, Pneumothorax, Respiratory distress serious: 1 patientsex: 1 drugs: AMPHOTERICIN B, ETHAMBUTOL HYDROCHLORIDE, ISONIAZID, MEROPENEM, PYRAZINAMIDE, PYRIDOXINE, RIFAMPIN reactions: Bronchopulmonary aspergillosis, Drug interaction serious: 1 patientsex: 1 drugs: LEVETIRACETAM, TOPIRAMATE reactions: Drug-induced liver injury serious: 1 patientsex: 1 drugs: CISPLATIN, CYCLOPHOSPHAMIDE, CYTARABINE, DEXAMETHASONE, DOXORUBICIN, GEMCITABINEGEMCITABINE HYDROCHLORIDE, PREDNISONE, RITUXIMAB, VINCRISTINE reactions: Gastrointestinal haemorrhage, Shock haemorrhagic serious: 1 patientsex: 1 drugs: SORAFENIB reactions: Diarrhoea, Palmar-plantar erythrodysaesthesia syndrome, Retinal vein occlusion serious: 1 patientsex: 1 drugs: NIVOLUMAB reactions: Cholangitis serious: 1 patientsex: 2 drugs: AMLODIPINE BESYLATE, OLMESARTAN reactions: Autoimmune hepatitis, Drug-induced liver injury serious: 1 patientsex: 1 drugs: CARBON MONOHYDRATE reactions: Dementia, Neuropsychiatric syndrome serious: 1 patientsex: 2 drugs: ABACAVIR, LAMIVUDINE reactions: Anaemia, Exposure during pregnancy, Hypersensitivity, Nausea, Vomiting serious: 1 patientsex: 2 drugs: AMLODIPINE BESYLATE, ASPIRIN, BISOPROLOL, HYDROCHLOROTHIAZIDE, INSULIN GLARGINE, LEVOTHYROXINE, METFORMIN HYDROCHLORIDE, NITROGLYCERIN, LOSARTAN reactions: Acute kidney injury, Chronic kidney disease, Drug interaction, Hypoxia, Renal tubular injury serious: 1 patientsex: 2 drugs: PREDNISONE, THALIDOMIDE reactions: Ascites, Hepatic failure, Hepatosplenomegaly, Oesophageal candidiasis, Septic shock serious: 1 patientsex: 2 drugs: BEVACIZUMAB, TEMOZOLOMIDE reactions: Disease progression, Hemiparesis, Leukopenia, Thrombocytopenia serious: 1 patientsex: 1 drugs: AMPHOTERICIN B, CASPOFUNGIN, INTERFERON GAMMA, ITRACONAZOLE, VORICONAZOLE reactions: Brain abscess, Headache, Visual impairment serious: 1 patientsex: 1 drugs: FLUOROURACIL, LEUCOVORIN, OXALIPLATIN reactions: Hypersensitivity vasculitis serious: 1 patientsex: 2 drugs: LISINOPRIL, HYDROCHLOROTHIAZIDELISINOPRIL SULFATE, SPIRONOLACTONE reactions: Hypercalcaemia serious: 1 patientsex: 1 drugs: BETAMETHASONE ACETATE, BETAMETHASONE HYDROCHLORIDE, HYDROCORTISONE BUTYRATE, INSULIN NOS, MOMETASONE FUROATE, PSORALENULTRAVIRIDE PHOSPHATE, VOGLIBOSE reactions: Hypoglycaemia, Staphylococcal infection serious: 1 patientsex: 2 drugs: INFLIXIMAB, METHOTREXATE reactions: Histoplasmosis disseminated, Ileal stenosis serious: 1 patientsex: 1 drugs: ATENOLOL, CITALOPRAM HYDROBROMIDE, CLONAZEPAM, CLOZAPINE, DIVALPROEX SODIUM, FLUOXETINE HYDROCHLORIDE, HALOPERIDOL, LITHIUM, OLANZAPINE, RISPERIDONE reactions: Drug ineffective, Microseizure, Speech disorder serious: 1 patientsex: 1 drugs: SORAFENIB reactions: Recall phenomenon serious: 1 patientsex: 1 drugs: AMLODIPINE BESYLATE, OLMESARTAN MEDOXOMIL reactions: Acute kidney injury, Metabolic acidosis, Sprue-like enteropathy serious: 1 patientsex: 1 drugs: NIVOLUMAB reactions: Disease progression, Fatigue, Arthralgia, Malignant neoplasm progression, Metastases to pelvis, Renal cell carcinoma, Right ventricular failure serious: 1 patientsex: 1 drugs: MIRTAZAPINE, SERTRALINE HYDROCHLORIDE reactions: Bradyarrhythmia, Hypotension, Overdose serious: 1 patientsex: 2 drugs: FLUOROURACIL, LEUCOVORIN, OXALIPLATIN reactions: Diabetic ketoacidosis, Diabetes mellitus serious: 1 patientsex: 2 drugs: CISPLATIN, DOXORUBICIN reactions: Off label use serious: 1 patientsex: 1 drugs: CIPROFLOXACIN, METRONIDAZOLE reactions: Bacteraemia, Drug resistance, Pyelonephritis serious: 1 patientsex: 2 drugs: DESVENLAFAXINE HYDROCHLORIDE, SUMITRIPTAN reactions: Acute myocardial infarction, Arteriospasm coronary, Electrocardiogram ST segment elevation serious: 1 patientsex: 2 drugs: ANASTROZOLE, CYCLOPHOSPHAMIDE, DOXORUBICIN, EXEMESTANE, FLUOROURACIL, PACLITAXEL, TEMOZOLOMIDE reactions: Febrile neutropenia, Diarrhoea, Fatigue, Metastases to lung, Metastases to lymph nodes, Metastases to mediastinum, Metastases to lymph nodes, Metastases to mediastinum, Metastases to lymph nodes, Metastases to mediastinum, Metastases to lymph nodes, Metastases to mediastinum, Metastases to lymph nodes, Metastases to mediastinum, Metastases to lymph nodes, Metastases to mediastinum, Metastases to lymph nodes, Metastases to mediastinum, Metastases to lymph nodes, Metastases to mediastinum, Metastases to lymph nodes, Metastases to mediastinum, Metastases to lymph nodes, Metastases to mediastinum, Metastases to lymph nodes, Metasta serious: 2 patientsex: 2 drugs: DENOSUMAB reactions: Drug ineffective serious: 1 patientsex: 1 drugs: CYCLOSPORINE, TACROLIMUS reactions: Glomerulonephritis serious: 1 patientsex: 1 drugs: CISPLATIN, FLUOROURACIL reactions: Acute kidney injury, Crystal nephropathy serious: 1 patientsex: 1 drugs: METHYLPHENIDATE HYDROCHLORIDE, RISPERIDONE reactions: Dystonia serious: 1 patientsex: 2 drugs: CLARITHROMYCIN, METHOTREXATE reactions: Abortion spontaneous, Exposure during pregnancy serious: 1 patientsex: 2 drugs: METRONIDAZOLE, PAROMOMYCIN reactions: Exposure during pregnancy serious: 1 patientsex: 2 drugs: DICLOPHENIRAMINE, FENTANYL, LEFLUNOMIDE, NORTRIPTYLINE reactions: Abdominal pain, Constipation, Drug interaction, Nausea, Myocardial infarction, Vomiting serious: 1 patientsex: 2 drugs: LISINOPRIL reactions: Angioedema serious: 1 patientsex: 2 drugs: CEFTRIAXONE, DOXYCYCLINE reactions: Choreoathetosis serious: 1 patientsex: 2 drugs: ASPIRIN, ATORVASTATIN, BISOPROLOL, ESCITALOPRAM OXALATE, ISOSORBIDE MONONITRATE, LIDOCAINE, LEVOBUPIVACAINE, TELMISARTAN reactions: Bradycardia, Hypotension, Loss of consciousness, Respiratory arrest, Somnolence serious: 1 patientsex: 2 drugs: AZATHIOPRINE, CYCLOSPORINE, HYDROXYCHLOROQUINE, METHOTREXATE, MYCOPHENOLATE MOFETIL, PREDNISOLONE, RITUXIMAB reactions: Drug intolerance, Drug resistance, Leukopenia, Product use in unapproved indication, Rash serious: 1 patientsex: 1 drugs: ALBUTEROL, AZITHROMYCIN ANHYDROUS, CLONIDINE, BUSPIRONE HYDROCHLORIDE, CLONIDINE HYDROCHLORIDE, CITALOPRAM HYDROBROMIDE, GUANFACINE, LEVOCETIRIZINE, MONTELUKAST SODIUM, SERTRALINE HYDROCHLORIDE reactions: Anxiety, Drug ineffective, Drug intolerance, Irritability, Suicidal ideation serious: 1 patientsex: 1 drugs: ISOTRETINOIN reactions: Depression, Insomnia, Irritability, Sacroiliitis serious: 1 patientsex: 1 drugs: METHYLPREDNISOLONE reactions: Factor VIII increased serious: 1 patientsex: 1 drugs: COLISTIN, MEROPENEM reactions: Drug resistance serious: 1 patientsex: 1 drugs: CAPECITABINE, OXALIPLATIN reactions: Bone marrow failure, Neurotoxicity, Vomiting serious: 1 patientsex: 1 drugs: MYCOPHENOLATE MOFETIL reactions: Drug ineffective serious: 1 patientsex: 2 drugs: CLINDAMYCIN, CIPROFLOXACIN, MEROPENEM, TIGECYCLINE reactions: Mycobacterium chelonae infection, Pneumonia serious: 1 patientsex: 2 drugs: PENICILLAMINE reactions: Anti-neutrophil cytoplasmic antibody positive vasculitis, Pulmonary-renal syndrome serious: 1 patientsex: 2 drugs: PEGINTERFERON ALFA-2A, RIBAVIRIN, TELAPREVIR reactions: Neutropenia, Thrombocytopenia serious: 1 patientsex: 1 drugs: ALLOPURINOL, ASPIRIN, ATORVASTATIN, DOCUSATE, DILTIAZEM, LISINOPRIL, TRAMADOL reactions: Acute kidney injury, Nephrotic syndrome, Interstitial nephritis serious: 1 patientsex: 2 drugs: METHAMPHETAMINE, SUMATRIPTAN reactions: Drug abuse, Reversible cerebral vasoconstriction syndrome serious: 1 patientsex: 1 drugs: CARBAMAZEPINE reactions: Seizure serious: 1 patientsex: 2 drugs: DROSPIRENONEETHINYL ESTRADIOL reactions: Macular neuroretinopathy serious: 1 patientsex: 2 drugs: BASILIXIMAB, HUMAN IMMUNOGLOBULIN G, METHYLPREDNISOLONE, MYCOPHENOLATE MOFETIL, RITUXIMAB, TACROLIMUS reactions: Retroperitoneal haematoma serious: 1 patientsex: 2 drugs: LENALIDOMIDE, RITUXIMAB reactions: COVID-19, Chest discomfort, Dizziness, Electrocardiogram QRS complex prolonged, Hypotension, Sinus bradycardia serious: 1 patientsex: 2 drugs: FENTANYL, NITROUS OXIDE, SEVOFLURANE, THIOPENTALIN reactions: Dystonia serious: 1 patientsex: 1 drugs: VALPROIC ACID reactions: Coma, Hyperammonaemia, Overdose, Respiratory acidosis serious: 1 patientsex: 2 drugs: ASPARAGINASE, CYCLOPHOSPHAMIDE, DOXORUBICIN, FILGRASTIM, PREDNISOLONE, VINCRISTINE reactions: Endometritis, Leukopenia, Neutropenia, Pseudomonas infection, Vaginal haemorrhage serious: 1 patientsex: 2 drugs: ASPIRIN reactions: Foetal death, Premature baby serious: 1 patientsex: 1 drugs: ACETAMINOPHEN, CODEINE PHOSPHATE, IBUPROFEN reactions: Hereditary angioedema serious: 1 patientsex: 2 drugs: BEVACIZUMAB, CARBOPLATIN, DOXORUBICIN HYDROCHLORIDE, ETOPOSIDE, IRINOTECAN, NEDAPLATIN reactions: Drug ineffective, Neoplasm progression serious: 1 patientsex: 2 drugs: ERTAPENEM SODIUM reactions: Off label use serious: 1 patientsex: 1 drugs: PROPOFOL, REMIFENTANIL, ROCURONIUM BROMIDE reactions: Anaphylactic reaction serious: 1 patientsex: 1 drugs: AMOXICILLIN, ACTRAPID, INSULIN NOS, OMEPRAZOLE, TRAMADOL reactions: Hiccups serious: 1 patientsex: 2 drugs: AZITHROMYCIN ANHYDROUS, ETHAMBUTOL HYDROCHLORIDE, MOXIFLOXACIN, RIFAMPIN reactions: Drug ineffective serious: 1 patientsex: 2 drugs: FLUOROURACIL, LEUCOVORIN, OXALIPLATIN reactions: Neutropenic colitis serious: 1 patientsex: 2 drugs: TOPIRAMATE reactions: Angle closure glaucoma, Choroidal effusion, Thrombocytopenia serious: 1 patientsex: 1 drugs: ARIPIPRAZOLE, AMPHETAMINE, FLUOXETINE HYDROCHLORIDE, METHYLPHENIDATE HYDROCHLORIDE, QUETIAPINE, TOPIRAMATE reactions: Drug ineffective, Drug interaction serious: 1 patientsex: 2 drugs: CYCLOPHOSPHAMIDE, METFORMIN HYDROCHLORIDE, MYCOPHENOLATE MOFETIL, PREDNISONE, TACROLIMUS reactions: Acute kidney injury, Asthenia, Diabetes mellitus, Haematuria, Neutropenia, Pneumonia, Renal failure, Respiratory failure, Urinary tract infection serious: 1 patientsex: 1 drugs: ALLOPURINOL, AZATHIOPRINE, FOLIC ACID, HYDRALAZINE HYDROCHLORIDE, HYDROXYUREA, DILTIAZEM, LEVOTHYROXINE, TACROLIMUS, TORSEMIDE reactions: Drug interaction, Pancytopenia serious: 1 patientsex: 1 drugs: EMPAGLIFLOZIN, GLIPHENURIDE, SITAGLIPTIN reactions: Fourniers gangrene serious: 1 patientsex: 1 drugs: HYDROCHLOROTHIAZIDEOLMESARTAN MEDOXOMIL, SIMVASTATIN reactions: Acute kidney injury, Dehydration, Diarrhoea, Weight decreased serious: 1 patientsex: 2 drugs: ARIPIPRAZOLE, CLONAZEPAM, FLUOXETINE HYDROCHLORIDE, IMIPRINE, NABUMEONE, SIMVASTATIN, VALSARTAN reactions: Stress cardiomyopathy serious: 1 patientsex: 1 drugs: ESCITALOPRAM OXALATE reactions: Depression, Drug interaction, Hypothyroidism, Suicide attempt serious: 1 patientsex: 2 drugs: BASILIXIMAB, METHYLPREDNISOLONE, MYCOPHENOLATE MOFETIL, PREDNISONE, TACROLIMUS reactions: Diabetic ketoacidosis, Transplant dysfunction serious: 1 patientsex: 2 drugs: ENALAPRIL, SIMVASTATIN reactions: Aortic occlusion, Drug ineffective, Diffuse dermal angiomatosis serious: 1 patientsex: 2 drugs: CEFURoxiME, LEVOFLOXACIN, PREDNISONE reactions: Intestinal failure, Multiple organ dysfunction syndrome serious: 1 patientsex: 2 drugs: LEFLUNOMIDE, MELOXICAM, METHOTREXATE, PREDNISONE reactions: Myelodysplastic syndrome, Rash, Skin haemorrhage serious: 1 patientsex: 1 drugs: DULOXETINE, DOXYCYCLINE, FENOFIBRATE, METFORMIN HYDROCHLORIDE, TRAZODONE HYDROCHLORIDE reactions: Abdominal pain, Diarrhoea, Leukocytosis, Pancreatitis acute, Tachycardia, Tachypnoea serious: 2 patientsex: 1 drugs: ASPIRIN, DIPYRIDAMOLE reactions: No adverse event serious: 1 patientsex: 1 drugs: NICARDIPINE, METOCLOPRAMIDE, PHENTOLAMINE reactions: Drug ineffective serious: 1 patientsex: 1 drugs: BUSULFAN, CYCLOSPORINE reactions: Chiari malformation, Sleep apnoea syndrome serious: 1 patientsex: 2 drugs: OFLOXACIN, ONDANSETRON reactions: Delirium, Hallucination, visual serious: 1 patientsex: 1 drugs: DEXAMETHASONE, LEVETIRACETAM reactions: Glioblastoma multiforme serious: 1 patientsex: 1 drugs: DEXAMETHASONE, HYDROCORTISONE, NITRIC OXIDE reactions: Cardiomegaly, Hypertension serious: 1 patientsex: 2 drugs: COLISTIN, MEROPENEM, POLYMYXIN B, TIGECYCLINE reactions: Disseminated intravascular coagulation, Skin hyperpigmentation serious: 1 patientsex: 1 drugs: CIPEEMINE, PIPERACILLIN SODIUMTAZOBACTAM SODIUM, TIGECYCLINE reactions: Drug resistance serious: 1 patientsex: 2 drugs: CHLOROQUINE PHOSPHATE, CIPROFLOXACIN, HEPARIN SODIUM, MEROPENEM reactions: Arrhythmia, Multiple organ dysfunction syndrome, Torsade de pointes serious: 1 patientsex: 2 drugs: METHYLPREDNISOLONE, SODIUM CHLORIDE reactions: Cushingoid, Diabetes mellitus, Hypoglycaemia, Proctatatis, Perianal abscess serious: 1 patientsex: 1 drugs: CARBOPLATIN, ASPIRIN, NIVOLUMAB, PACLITAXEL reactions: Organising pneumonia serious: 1 patientsex: 1 drugs: ACETAMINOPHEN, HEPARIN SODIUM, GABAPENTIN, HEPARIN SODIUM, SILVER SULFADIAZINE reactions: Retroperitoneal haematoma serious: 2 patientsex: 1 drugs: BUPIVACAINE HYDROCHLORIDE, CYCLOSPORINE, GABAPENTIN reactions: Off label use serious: 1 patientsex: 1 drugs: GLATIRAMER ACETATE reactions: Abortion spontaneous, Exposure during pregnancy serious: 1 patientsex: 2 drugs: AZATHIOPRINE reactions: Epstein-Barr virus infection, Trigeminal neuralgia serious: 1 patientsex: 1 drugs: DEXAMETHASONE reactions: Acute myocardial infarction, Drug abuse serious: 1 patientsex: 2 drugs: PREDNISOLONE reactions: Nephrotic syndrome, Urinary bladder oedema serious: 1 patientsex: 1 drugs: LEFLUNOMIDE, PREDNISONE reactions: Anaemia, Gastritis, Mucormycosis, Upper gastrointestinal haemorrhage serious: 1 patientsex: 1 drugs: TAMOXIFEN reactions: Lung injury serious: 1 patientsex: 2 drugs: ARGATROBAN, ASPIRIN, CLOPIDOGREL BISULFATE, IOPAMIDOL reactions: Contrast encephalopathy serious: 1 patientsex: 1 drugs: LEFLUNOMIDE, METHOTREXATE reactions: Lymphadenitis, Mycobacterium paraffinicum infection serious: 2 patientsex: 2 drugs: GLIMEPIRIDE, INSULIN NOS, METFORMIN HYDROCHLORIDE reactions: Hypoglycaemia serious: 1 patientsex: 1 drugs: EMPAGLIFLOZIN, GLIPIZIDE, LINAGLIPTIN, METFORMIN HYDROCHLORIDE reactions: Fourniers gangrene serious: 1 patientsex: 2 drugs: DOCETAXEL, PACLITAXEL, TRASTUZUMAB, ZOLEDRONIC ACID reactions: Cardiogenic shock, Drug hypersensitivity, Neuropathy peripheral serious: 1 patientsex: 1 drugs: DOCETAXEL reactions: Febrile neutropenia serious: 1 patientsex: 1 drugs: DIGOXIN, INSULIN NOS, PREDNISOLONE, URSODIOL reactions: Chronic kidney disease, Protothecosis serious: 1 patientsex: 2 drugs: ASPIRIN, ENOXAPARIN, HYDROXYPROGESTERONE, METFORMIN HYDROCHLORIDE, ESTRADIOL reactions: Acute diabetic ketoacidosis, Hypertriglyceridaemia, Pancreatitis haemorrhagic serious: 1 patientsex: 1 drugs: CALCIUM FOLIC ACID, METHOTREXATE reactions: Death, Neurotoxicity serious: 1 patientsex: 1 drugs: ROSUVASTATIN CALCIUM reactions: Drug-induced liver injury serious: 1 patientsex: 1 drugs: CEFTRIAXONE reactions: Drug ineffective serious: 1 patientsex: 2 drugs: BORTEZOMIB, CISPLATIN, CYCLOPHOSPHAMIDE, DEXAMETHASONE, ETOPOSIDE reactions: Plasma cell myeloma serious: 1 patientsex: 1 drugs: BLEOMYCIN SULFATE, AZATHIOPRINE, BLEOMYCIN SULFATE, DACARBAZINE, DOXORUBICIN, GANCICLOVIR, LEFLUNOMIDE, METHYLPREDNISOLONE, MYCOPHENOLATE MOFETIL, RITUXIMAB, VINBLASTINE reactions: Aortic valve disease, Aortic stenosis, Aortic valve disease reactivation, Aortic valve disease, Aortic valve disease, Aortic valve disease, Aortic valve disease, Aortic valve disease, Aortic valve disease, Aortic valve disease, Aortic valve disease, Aortic valve disease, Aortic valve disease, Aortic valve disease, Aortic valve disease, Aortic valve disease, Aortic valve disease, Aortic valve disease, Aortic valve disease, Aortic valve disease, Aortic valve disease, Aortic valve disease, Aortic valve disease, Aortic valve disease, Aortic valve disease serious: 1 patientsex: 1 drugs: ALEMTUZUMAB, CYCLOPHOSPHAMIDE, DEXAMETHASONE, FLUDARABINE PHOSPHATE, IBRUTINIB, POSACONAZOLE, SULFAMETHOXAZOLETRIMETHOPRIM, VALACYCLOVIR HYDROCHLORIDE reactions: Febrile neutropenia, Myositis serious: 1 patientsex: 2 drugs: AMOXICILLINCLAVULANIC ACID, CEFTRIAXONE, LEVOFLOXACIN, GENTAMICIN, TEICOPLANIN reactions: Drug ineffective serious: 1 patientsex: 1 drugs: ALENDAZOLE, BISOCODIL, PRAZIQUANTEL reactions: Hepatitis serious: 1 patientsex: 2 drugs: ETANERCEPT, GOLIMUMAB reactions: Blindness, Depressed level of consciousness, Treatment noncompliance serious: 1 patientsex: 1 drugs: CEFDINIR, INSULIN NOS, PREDNISONE reactions: Diabetes mellitus, Nocardiosis, Pneumonia serious: 1 patientsex: 2 drugs: CISPLATIN reactions: Acute kidney injury, Thrombocytopenia serious: 1 patientsex: 2 drugs: INTERFERON BETA-1B reactions: Thrombotic microangiopathy serious: 2 patientsex: 2 drugs: METFORMIN HYDROCHLORIDE reactions: Exposure during pregnancy serious: 1 patientsex: 2 drugs: AZACITIDINE, EMTRICITABINE, TENOFOVIR DISOPROXIL FUMARATE reactions: Acute myeloid leukaemia, Cytopenia, Pseudomonas infection, Pyrexia serious: 1 patientsex: 2 drugs: DIAZOXIDE, LISINOPRIL reactions: Deep vein thrombosis, Swelling serious: 1 patientsex: 1 drugs: ASPIRIN, LANSOPRAZOLE, TICLOPIDINE reactions: Colitis microscopic serious: 1 patientsex: 1 drugs: MYCOPHENOLIC ACID, PREDNISONE, SIROLIMUS reactions: Epstein-Barr virus infection, Haemophagocytic lymphohistiocytosis serious: 2 patientsex: 1 drugs: BORTEZOMIB, DEXAMETHASONE, LENALIDOMIDE reactions: Irritability serious: 1 patientsex: 1 drugs: AZITHROMYCIN ANHYDROUS, CEFTRIAXONE SODIUM, FAVIPIRAVIR reactions: Dysphagia, Pneumonia aspiration serious: 1 patientsex: 2 drugs: ORLISTAT reactions: Diarrhoea, Drug interaction, Urinary retention serious: 1 patientsex: 2 drugs: IMATINIB MESYLATE reactions: Acute hepatic failure, Chronic myeloid leukaemia serious: 1 patientsex: 1 drugs: CARBOPLATIN, PACLITAXEL, ZOSYN TARTRATE reactions: Febrile neutropenia, Colitis bacterial, Febrile neutropenia, Pneumonia, Respiratory distress, Sepsis serious: 1 patientsex: 1 drugs: VISMODEGIB reactions: Decreased appetite, Muscle spasms, Rash pruritic serious: 1 patientsex: 1 drugs: BOSENTAN, HEPARIN SODIUM, MORPHINE, SILDENAFIL, VANCOMYCIN reactions: Drug ineffective, Off label use, Product use in unapproved indication serious: 1 patientsex: 2 drugs: AZITHROMYCIN ANHYDROUS, CYCLOPHOSPHAMIDE, METHYLPREDNISOLONE, OMALIZUMAB, PREDNISONE, RIFLUMILAST, TEMOZOLOMIDE reactions: Drug ineffective, Off label use serious: 1 patientsex: 2 drugs: BACLOFEN, PREGABALIN reactions: Drug ineffective serious: 1 patientsex: 1 drugs: ALFACALCIDOL, ASPIRIN, CALCIUM CARBONATE, CARVEDILOL, DILTIAZEM, ESOMEPRAZOLE MAGNESIUM, LINAGLIPTIN, NICORANDIL, PRASUGREL, ROSUVASTATIN, WARFARIN reactions: Drug-induced liver injury serious: 1 patientsex: 2 drugs: HYDROXYCHLOROQUINE, HYDROXYZINE HYDROCHLORIDE, FEXOFENADINE, PREDNISONE reactions: Drug ineffective serious: 1 patientsex: 2 drugs: DAUNORUBICIN, PEGASPARGASE, VINCRISTINE reactions: Acute kidney injury, Hypertension, Toxicity to various agents serious: 1 patientsex: 2 drugs: CYCLOSPORINE, VANCOMYCIN reactions: Clostridium difficile infection serious: 1 patientsex: 1 drugs: CASPOFUNGIN, CLINDAMYCIN, LINEZOLID, PIPERACILLIN SODIUMTAZOBACTAM SODIUM, VANCOMYCIN reactions: Drug ineffective serious: 1 patientsex: 1 drugs: BEVACIZUMAB, DOCETAXEL reactions: Skin reaction serious: 1 patientsex: 2 drugs: ASPIRIN, DIPYRIDAMOLE reactions: Gastrointestinal haemorrhage serious: 1 patientsex: 2 drugs: VALPROIC ACID reactions: Seizure serious: 1 patientsex: 2 drugs: BEVACIZUMAB, ASPIRIN, CYCLOPHOSPHAMIDE, CYTARABINE, METHYLPREDNISOLONE, PREDNISOLONE, RITUXIMAB, VINCRISTINE reactions: Diabetic nephropathy, Focal segmental glomerulosclerosis, Interstitial nephritis serious: 1 patientsex: 1 drugs: DEFERASIROX, DEFEROXAMINE MESYLATE reactions: Headache, Skin reaction serious: 1 patientsex: 2 drugs: ATAZANAVIR, LAMIVUDINE, NEVIRAPINE, ZIDOVUDINE reactions: Treatment failure serious: 1 patientsex: 1 drugs: IBRUTINIB reactions: Haemorrhage intracranial serious: 1 patientsex: 2 drugs: DOXORUBICIN HYDROCHLORIDE reactions: Death, Neurotoxicity serious: 1 patientsex: 1 drugs: ALLOPURINOL reactions: Lichenoid keratosis serious: 1 patientsex: 1 drugs: NILOTINIB reactions: Drug withdrawal syndrome serious: 1 patientsex: 2 drugs: CEFTRIAXONE, LORAZEPAM, PANTOPRAZOLE SODIUM, VALPROIC ACID reactions: Resting tremor serious: 1 patientsex: 1 drugs: CISPLATIN, GIMERACILOTERACILTEGAFUR reactions: Malaise, Renal disorder serious: 1 patientsex: 1 drugs: HYDROXYUREA reactions: Anaemia, Pneumonia, Respiratory failure serious: 1 patientsex: 2 drugs: ALLOPURINOL, CARBAMAZEPINE, PHENYTOIN, VALPROIC ACID reactions: Drug reaction with eosinophilia and systemic symptoms serious: 1 patientsex: 1 drugs: NIVOLUMAB reactions: Autoimmune hepatitis, Hepatitis cholestatic serious: 1 patientsex: 2 drugs: CYCLOSPORINE, PREDNISOLONE reactions: Bone fracture, Insomnia serious: 1 patientsex: 1 drugs: HEPARIN SODIUM reactions: Heparin-induced thrombocytopenia serious: 1 patientsex: 2 drugs: CIPROFLOXACIN, PREDNISOLONE, RIFAMPIN reactions: Nausea, Rash serious: 1 patientsex: 2 drugs: FLUOROURACIL, IRINOTECAN, LEUCOVORIN, OXALIPLATIN reactions: Drug ineffective serious: 1 patientsex: 2 drugs: ALENDRONATE SODIUM, ASPIRIN, CALCIUM CARBONATEVITAMIN D NOS, HYDROXYCHLOROQUINE, NITROGLYCERIN, PREDNISONE reactions: Scleroderma renal crisis serious: 1 patientsex: 2 drugs: CYCLOPHOSPHAMIDE, DOXORUBICIN, PREDNISOLONE, RITUXIMAB, VINCRISTINE reactions: Caesarean section, Ectopic pregnancy serious: 1 patientsex: 2 drugs: BOSUTINIB, DASATINIB, IMATINIB MESYLATE, INTERFERON, PONATINIB reactions: Eczema, Pityriasis serious: 1 patientsex: 2 drugs: ATRACURIUM, DESFLURANE, ETOMIDATE, HEPARIN SODIUM, MIDAZOLAM HYDROCHLORIDE, NOREPINEPHRINE, PROTAMINE SULFATE, REMIFENTANIL, OXYGEN, NOREPINEPHRINE, REMIFENTANIL, MIDAZOLAM HYDROCHLORIDE, OXYGEN, REMIFENTANIL, NOREPINEPHRINE, MIDAZOLAM HYDROCHLORIDE, PROTAMINE SULFATE, REMIFENTANIL, PROTAMINE SULFATE, NOREPINEPHRINE, PROTAMINE SULFATE, REMIFENTANIL, NOREPINEPHRINE, PROTAMINE SULFATE, NOREPINEPHRINE, PROTAMINE SULFATE, REMIFENTANIL, NOREPINEPHRINE, PROTAMINE SULFATE, PROTAMINE SULFATE, REM serious: 1 patientsex: 1 drugs: ALPRAZOLAM, XANAX reactions: Acute kidney injury, Coma, Hyperkalaemia, Hypoxia, Leukocytosis, Metabolic acidosis, Overdose, Respiratory failure, Septic shock, Tachycardia, Vomiting serious: 1 patientsex: 2 drugs: CYTARABINE, FLUDARABINE PHOSPHATE, IDARUBICIN, GRANULOCYTE COLONY-STIMULATING FACTOR NOS, VORICONAZOLE reactions: Febrile neutropenia serious: 1 patientsex: 2 drugs: COLCHICINE reactions: Aspergillus infection, Cerebral haemorrhage serious: 1 patientsex: 2 drugs: COLCHICINE, DABIGATRAN ETEXILATE MESYLATE, PANTOPRAZOLE SODIUM reactions: Pericardial effusion, Pleural effusion serious: 1 patientsex: 2 drugs: ASPIRIN, HEPARIN SODIUM, METOPROLOL, POTASSIUM reactions: Ventricular tachycardia serious: 1 patientsex: 1 drugs: LEDIPASVIR, SIMEPREVIR, SOFOSBUVIR reactions: Hepatitis C serious: 1 patientsex: 1 drugs: CYCLOPHOSPHAMIDE, HYDROXYCHLOROQUINE reactions: Hepatic ischaemia, Hepatic artery thrombosis, Perivascular epithelioid cell tumour serious: 1 patientsex: 2 drugs: DENOSUMAB reactions: Hypercalcaemia, Hypercalciuria serious: 1 patientsex: 1 drugs: ABIRATERONE ACETATE, 223RaDICHLORIDE, PREDNISONE reactions: Disease progression serious: 1 patientsex: 2 drugs: FENTANYL, PROPOFOL, REMIFENTANIL, SEVOFLURANE reactions: Hypercapnia serious: 1 patientsex: 1 drugs: ASPIRIN, COBICISTAT, ELVITEGRAVIR, EMTRICITABINE, FOLIC ACID, FERROUS SULFATE, LISINOPRIL, METOPROLOL, MIRTAZAPINE, TENOFOVIR ALAFENAMIDE, SOFOSBUVIR reactions: Acute kidney injury, Hyperkalaemia, Renal tubular acidosis serious: 1 patientsex: 2 drugs: CARBOPLATIN, PEMETREXED reactions: Toxicity to various agents serious: 1 patientsex: 2 drugs: CYCLOPHOSPHAMIDE, DOXORUBICIN, PREDNISONE, RITUXIMAB, VINCRISTINE reactions: Amenorrhoea, Premature menopause, Premature ovulation serious: 1 patientsex: 2 drugs: CHOLECALCIFEROL, METFORMIN HYDROCHLORIDE, URSODIOL reactions: Exposure during pregnancy, Sleep disorder, Somnolence serious: 1 patientsex: 2 drugs: CHLORPROMAZINE, OLANZAPINE reactions: Cataract nuclear, Corneal deposition, Corneal toxicity, Pupils unequal, Visual acuity reduced serious: 1 patientsex: 1 drugs: BRODOMIDOL, WARFARIN reactions: Haematuria, Intentional overdose, Prothrombin time prolonged, Toxicity to various agents serious: 1 patientsex: 1 drugs: AMLODIPINE BESYLATE, IMATINIB, METFORMIN HYDROCHLORIDE, SIMVASTATIN, SITAGLIPTIN reactions: Gastric polyp serious: 1 patientsex: 2 drugs: ESTROGENS, PROGESTERONE reactions: Breast cancer, Infiltrative ductal carcinoma, Thyroid cancer serious: 1 patientsex: 1 drugs: CEFAZOLIN, EPINEPHRINE, FENTANYL, MORPHINE, ROPIVACAINE HYDROCHLORIDE reactions: Atelectasis, Sleep disorder, Respiratory distress, Sedation disorder serious: 1 patientsex: 1 drugs: DIAZEPAM, PHENYTOIN, RANITIDINE reactions: Drug interaction, Hypersensitivity, Rash erythematous, Toxicity to various agents serious: 1 patientsex: 1 drugs: CIPROFLOXACIN reactions: Hypersensitivity, Rash serious: 1 patientsex: 2 drugs: AMBRISENTAN, EPOPROSTENOL, SILDENAFIL reactions: Drug ineffective serious: 1 patientsex: 2 drugs: MELPHALAN, TOPOTECAN HYDROCHLORIDE reactions: Choroidal atrophy, Vitreous haemorrhage serious: 1 patientsex: 1 drugs: AMINOCAPROIC ACID, DEXAMETHASONE, MYCOPHENOLIC ACID, PREDNISONE, RITUXIMAB, ROMIPLOSTIM reactions: Drug ineffective, Thrombocytosis serious: 1 patientsex: 1 drugs: AMPICILLIN SODIUMSULBACTAM SODIUM, PIPERACILLIN SODIUMTAZOBACTAM SODIUM, VANCOMYCIN reactions: Drug ineffective serious: 1 patientsex: 1 drugs: AMIODARONE, ATORVASTATIN, BISOPROLOL, WARFARIN reactions: Haemoptysis, Pulmonary toxicity serious: 1 patientsex: 1 drugs: FLUOROURACIL reactions: Accidental overdose, Cardiotoxicity, Neurotoxicity, Overdose, Suicide attempt serious: 1 patientsex: 1 drugs: AMLODIPINE BESYLATE, ATENOLOL, HYDROCHLOROTHIAZIDE, SPIRONOLACTONE reactions: Gynaecomastia serious: 1 patientsex: 2 drugs: TOPIRAMATE reactions: Angle closure glaucoma, Macular striae serious: 1 patientsex: 1 drugs: LOPERAMIDE HYDROCHLORIDE reactions: Brain injury, Brain injury serious: 1 patientsex: 1 drugs: INFLIXIMAB reactions: Abdominal pain, Abdominal discomfort, Diarrhoea, Ileus, Large intestine stenosis, Ocular ileus, Product use in unapproved indication, Small intestinal obstruction serious: 1 patientsex: 2 drugs: ANAKINRA, HYDROXYCHLOROQUINE reactions: Acute respiratory failure, Toxic myopathy serious: 1 patientsex: 2 drugs: MYCOPHENOLATE MOFETIL, PREDNISOLONE, SULFAMETHOXAZOLETRIMETHOPRIM, TACROLIMUS, VALGANCICLOVIR reactions: Bladder cancer, BK virus infection, Diarrhoea, Nephropathy, Papillary urothelial carcinoma, Proteinuria, Weight decreased serious: 1 patientsex: 1 drugs: MYCOPHENOLATE MOFETIL, PREDNISOLONE, TACROLIMUS, VALGANCICLOVIR reactions: Cytomegalovirus infection, Drug ineffective, Neutropenia, Pneumocystis jirovecii infection, Steroid diabetes serious: 1 patientsex: 1 drugs: BENZTROPINE, CHLORPROMAZINE, LEVOTHYROXINE, LORAZEPAM, LORAZEPAM HYDROCHLORIDE, LORAZEPAM HYDROCHLORIDE, LORAZEPAM HYDROCHLORIDE, LORAZEPAM, SPIRONOLACTONE, TAMSULOSIN reactions: Agranulocytosis, Drug interaction, Hypotension, Pyelonephritis, Septic shock serious: 1 patientsex: 2 drugs: BEVACIZUMAB, CISPLATIN, CYCLOPHOSPHAMIDE, DOCETAXEL, EPIRUBICIN, GEMCITABINEGEMCITABINE HYDROCHLORIDE, IFOSFAMIDE, VINCRISTINE reactions: Drug ineffective serious: 1 patientsex: 2 drugs: TAMOXIFEN, PREDNISOLONE reactions: Deep vein thrombosis, Hepatic infarction, Malnutrition, Sepsis, Venous thrombosis serious: 1 patientsex: 1 drugs: AMLODIPINE BESYLATE, CELECOXIB, FAMOTIDINE, IGURATIMOD, OLMESARTAN, PEMBROLIZUMAB, PREDNISOLONE reactions: Hepatosplenomegaly, Immune-mediated cytopenia, Off label use, Rash macular, White blood cell count decreased serious: 1 patientsex: 2 drugs: MANNITOL reactions: Drug ineffective serious: 1 patientsex: 1 drugs: CISPLATIN reactions: Nausea, Vomiting serious: 1 patientsex: 1 drugs: CYTARABINE, CHLORODEOXADENOSINE, PREDNISOLONE, VINBLASTINE reactions: Neutropenia, Pneumonia serious: 1 patientsex: 1 drugs: AMIKACIN, CILASTATIN SODIUMIMIPENEM, CLARITHROMYCIN, LINEZOLID, TIGECYCLINE reactions: Electrocardiogram QT prolonged serious: 1 patientsex: 2 drugs: HUMAN IMMUNOGLOBULIN G, PREDNISONE reactions: Stevens-Johnson syndrome serious: 1 patientsex: 1 drugs: AZITHROMYCIN ANHYDROUS, DEXMEDETOMIDINE, OSELTAMIVIR, PIPERACILLIN SODIUMTAZOBACTAM SODIUM, VANCOMYCIN reactions: Acute respiratory distress syndrome, Colitis ischaemic, Ileus, Megacolon serious: 1 patientsex: 1 drugs: ABIRATERONE ACETATE, BICALUTAMIDE, LEUPROLIDE ACETATE reactions: Breast cancer, Drug ineffective, Metastases to lymph nodes, Metastases to liver, Metastases to pancreas, Metastases to urinary bladder serious: 1 patientsex: 2 drugs: ENALAPRIL, FUROSEMIDE, METOPROLOL, MOFETIL MYCOPHENOLIC ACID, PREDNISONE, TACROLIMUS reactions: Anaemia, Chronic graft dysfunction, Drug ineffective, Overdose, Pneumonitis, Urinary tract infection serious: 1 patientsex: 2 drugs: PREDNISOLONE reactions: Cutaneous leishmaniasis serious: 1 patientsex: 2 drugs: CYCLOSPORINE, MYCOPHENOLATE MOFETIL reactions: Brain stem disorder, Meningitis viral, Pyrexia, Respiratory failure serious: 1 patientsex: 2 drugs: BETAMETHASONE, PREDNISOLONE reactions: Osteoporosis, Femoral neck fracture serious: 1 patientsex: 2 drugs: CARVEDILOL, DULOXETINE HYDROCHLORIDE, DILTIAZEM, FUROSEMIDE, LISINOPRIL reactions: Abdominal pain, Drug level increased, Haemoglobin decreased, Haemoglobin increased, Haemoglobin decreased, Haemoglobin increased, Haemoglobin decreased, Haemoglobin increased, Haemoglobin decreased, Haemoglobin increased, Haemoglobin decreased, Haemoglobin increased, Haemoglobin decreased, Haemoglobin increased, Haemoglobin decreased, Haemoglobin increased, Haemoglobin decreased, Haemoglobin increased, Haemoglobin decreased, Haemoglobin increased, Haemoglobin decreased, Haemoglobin increased, Haemoglobin decreased, Haemoglobin increased, Haemoglobin decreased, Haemoglobin increased, Haemo serious: 1 patientsex: 1 drugs: HALOPERIDOL, LURASIDONE reactions: Agranulocytosis, Leukopenia, Neutropenia serious: 1 patientsex: 2 drugs: CYCLOPHOSPHAMIDE, DOXORUBICIN, PREDNISONE, ROMIDEPSINE, VINCRISTINE reactions: Drug ineffective serious: 1 patientsex: 2 drugs: CYCLOPHOSPHAMIDE, CYTARABINE, DOXORUBICIN, ETOPOSIDE, IFOSFAMIDE, METHOTREXATE, RITUXIMAB, VINCRISTINE reactions: Drug ineffective serious: 1 patientsex: 2 drugs: ERIBULIN MESYLATE reactions: Interstitial lung disease serious: 1 patientsex: 1 drugs: CEFTRIAXONE reactions: Acute generalised exanthematous pustulosis serious: 1 patientsex: 2 drugs: FENTANYL, PROPOFOL, ROCURONIUM BROMIDE, SEVOFLURANE reactions: Airway collapse, Asthma, Wheezing serious: 1 patientsex: 2 drugs: MIRAFENIB reactions: Electrocardiogram QT prolonged, Electrocardiogram T wave amplitude increased, Ventricular extrasystoles serious: 1 patientsex: 1 drugs: AMOXICILLIN, ASPIRIN, DIPYRIDAMOLE, SUNITINIB MALATE reactions: Acute kidney injury, Haematuria, Hyponatraemia, Renal failure, Tubulointerstitial nephritis serious: 1 patientsex: 1 drugs: USTEKINUMAB reactions: Meningitis viral, Off label use serious: 1 patientsex: 2 drugs: OCTREOTIDE reactions: Disease progression serious: 1 patientsex: 2 drugs: NITROUS OXIDE reactions: Vitamin B12 deficiency, Myelopathy serious: 1 patientsex: 2 drugs: BLEOMYCIN SULFATE, CISPLATIN, ETOPOSIDE reactions: Ascites, Teratoma serious: 1 patientsex: 1 drugs: HUMAN IMMUNOGLOBULIN G, MYCOPHENOLIC ACID, PREDNISONE, PYRIDOSTIGMINE reactions: Histoplasmosis, Pulmonary cryptococcosis serious: 1 patientsex: 1 drugs: CYTARABINE, DEXRAZOXANE, ETOPOSIDE, MITOTANE reactions: Acute myeloid leukaemia recurrent, Cardiac failure congestive, Cardiomyopathy, Cardiotoxicity, Hypokinesia, Off label use, Sepsis serious: 1 patientsex: 2 drugs: METHOTREXATE, PREDNISOLONE reactions: Chorioretinal atrophy, Eye abscess, Mycobacterium tuberculosis serious: 1 patientsex: 2 drugs: CISPLATIN, PACLITAXEL reactions: Acute kidney injury, Cardiac arrest, Disseminated intravascular coagulation, Oesophageal oedema, Septic shock serious: 1 patientsex: 1 drugs: CAPECITABINE, OXALIPLATIN reactions: Wound infection serious: 1 patientsex: 1 drugs: CYCLOPHOSPHAMIDE, FILGRASTIM, ETHIODIZED OIL, MELPHALAN, PREDNISONE, SULFAMETHOXAZOLETRIMETHOPRIM reactions: Multiple sclerosis relapse serious: 1 patientsex: 1 drugs: PEMBROLIZUMAB reactions: Arthritis, Inflammatory polyarthritis serious: 1 patientsex: 2 drugs: METHYLPREDNISOLONE, PREDNISOLONE reactions: Drug ineffective, Exposure during pregnancy serious: 2 patientsex: 1 drugs: TOPIRAMATE reactions: Off label use serious: 1 patientsex: 2 drugs: MITOMYCIN reactions: Pterygium recurrence serious: 1 patientsex: 1 drugs: BISOPROLOL, DABIGATRAN ETEXILATE MESYLATE, FUROSEMIDE, RAMIPRIL reactions: Cardiac failure acute, Distal embolism, Embolism venous, Left ventricular dysfunction, Sinus tachycardia serious: 1 patientsex: 1 drugs: ASPIRIN, CLOPIDOGREL BISULFATE, RIVAROXABAN reactions: Atrial thrombosis, Drug ineffective serious: 1 patientsex: 1 drugs: FLUOROURACIL, RALTITREXED reactions: Coronary artery disease, Drug ineffective, Gastric adenocarcinoma, Hypercholesterolaemia, Malignant neoplasm progression, Metastases to liver, Metastases to intestine, Metastases to intestine, Metastases to liver, Metastases to intestine, Metastases to liver, Metastases to intestine, Metastases to intestine, Metastases to intestine, Metastases to intestine, Metastases to intestine, Metastases to intestine, Metastases to intestine, Metastases to intestine, Metastases to intestine, Metastases to intestine, Metastases to intestine, Metastases to intestine, Metastases to intestine, Metastases to intestine, Metastases to intestine, Metastases to intestine, Metastases to intestine, Metastases to intestine, Metastases to intestine, serious: 1 patientsex: 1 drugs: IMIPENEM, OMEPRAZOLE, PREDNISONE, TINZAPARIN reactions: Drug ineffective, Haematuria, Thrombocytopenia serious: 1 patientsex: 2 drugs: VINCRISTINE reactions: Peroneal neuropathy serious: 1 patientsex: 1 drugs: PREDNISOLONE, TACROLIMUS reactions: Dermatophytosis, Psoriasis, Psoriatic arthropathy serious: 1 patientsex: 1 drugs: AMLODIPINE BESYLATE, DABIGATRAN ETEXILATE MESYLATE, LEVETIRACETAM, METOPROLOL, TORSEMIDE reactions: Ischaemic stroke serious: 1 patientsex: 1 drugs: ATOVAQUONE, LINEZOLID, LEVOFLOXACIN, MEROPENEM, POSACONAZOLE, PREDNISONE, TACROLIMUS reactions: Nocardiosis, Paraesthesia serious: 1 patientsex: 1 drugs: CISPLATIN, DOCETAXEL reactions: Pulmonary infection serious: 1 patientsex: 2 drugs: CYCLOPHOSPHAMIDE, DOXORUBICIN, PREDNISOLONE, VINCRISTINE reactions: Pneumonia serious: 1 patientsex: 1 drugs: CARBOPLATIN, ETOPOSIDE, MELPHALAN reactions: Aspergillus infection, Bacterial sepsis, Lactobacillus infection, Respiratory distress, Sepsis serious: 1 patientsex: 2 drugs: CARBOPLATIN, PACLITAXEL reactions: Bradycardia, Cardiac block complete, Myocarditis serious: 1 patientsex: 2 drugs: DOCETAXEL, GEMCITABINEGEMCITABINE HYDROCHLORIDE, PAZOPANIB reactions: Acute respiratory distress syndrome, Pneumonitis serious: 1 patientsex: 1 drugs: KETAMINE HYDROCHLORIDE reactions: Drug abuse, Drug dependence, Drug-induced liver injury, Urinary bladder haemorrhage serious: 1 patientsex: 1 drugs: ASPIRIN, ATORVASTATIN, DABIGATRAN ETEXILATE MESYLATE, METFORMIN HYDROCHLORIDE, METOPROLOL reactions: Atrial fibrillation, Bronchiectasis, Dyspnoea, Granulomatous inflammation, International normalised ratio increased, Lymphocytosis, Mycobacterium tuberculosis, Pleural effusion, Pulmonary lymphoma, Pulmonary thickening, Pulmonary lymphocytosis, Pulmonary granuloma, Pulmonary lymphocytosis, Pulmonary thrombosis, Pulmonary granuloma, Pulmonary lymphocytosis, Pulmonary thrombosis, Pulmonary granuloma, Pulmonary thrombosis, Pulmonary lymphocytosis, Pulmonary thrombosis, Pulmonary granuloma, Pulmonary thrombosis, Pulmonary lympho serious: 1 patientsex: 2 drugs: BROMAZEPAM, METHYLPREDNISOLONE, PREDNISONE, ROSUVASTATIN reactions: Drug ineffective, Off label use serious: 1 patientsex: 1 drugs: MYCOPHENOLIC ACID, TACROLIMUS reactions: Acute kidney injury, Thrombotic microangiopathy serious: 1 patientsex: 1 drugs: ASPIRIN, METOPROLOL reactions: Tricuspid valve thrombosis serious: 1 patientsex: 1 drugs: CYCLOPHOSPHAMIDE, DOXORUBICIN, ERYTHROPOIETIN, PEGFILGRASTIM, PREDNISONE, VINCRISTINE reactions: Anaemia, Febrile neutropenia, Toxicity to various agents serious: 1 patientsex: 1 drugs: AMPHOTERICIN B, DOLUTEGRAVIR, EMTRICITABINE, ITRACONAZOLE, TENOFOVIR DISOPROXIL FUMARATE reactions: Drug level below therapeutic, Histoplasmosis disseminated serious: 1 patientsex: 1 drugs: RIBAVIRIN reactions: Drug interaction serious: 1 patientsex: 2 drugs: METHOTREXATE, PREDNISOLONE reactions: Drug eruption, Pneumocystis jirovecii infection serious: 1 patientsex: 1 drugs: AMPICILLIN, CEFTRIAXONE, MEROPENEM, VANCOMYCIN reactions: Rash maculo-papular serious: 1 patientsex: 2 drugs: ITRACONAZOLE, VORICONAZOLE reactions: Tendonitis serious: 1 patientsex: 1 drugs: AMIODARONE HYDROCHLORIDE, CARVEDILOL, FUROSEMIDE reactions: Hyperbilirubinaemia, Hyperthyroidism, Toxicity to various agents serious: 1 patientsex: 1 drugs: DABIGATRAN ETEXILATE MESYLATE reactions: Tubulointerstitial nephritis serious: 1 patientsex: 2 drugs: ENTECAVIR, SIROLIMUS reactions: Hepatitis B reactivation serious: 2 patientsex: 2 drugs: AZITHROMYCIN ANHYDROUS, CIPRO, CIPROFLOXACIN, CLARITHROMYCIN, CIPROFLOXACIN, CIPROFLOXACIN HYDROCHLORIDE, CLARITHROMYCIN, CIPROFLOXACIN, CLARITHROMYCIN, CIPROFLOXACIN, CLARITHROMYCIN, CIPROFLOXACIN, CLARITHROMYCIN HYDROCHLORIDE, CIPROFLOXACIN, CLARITHROMYCIN, CIPROFLOXACIN, CIPROFLOXACIN, CLARITHROMYCIN, CIPROFLOXACIN, CLARITHROMYCIN, CLARITHROMYCIN HYDROCHLORIDE, CLARITHROMYCIN SULFATE, CLARITHROMYCIN, CLARITHROMYCIN HYDROCHLORIDE, CLARITHROMYCIN SULF serious: 1 patientsex: 2 drugs: AZATHIOPRINE, ASPIRIN, METHYLDOPA, PREDNISOLONE reactions: COVID-19 serious: 1 patientsex: 2 drugs: MEDROXYPROGESTERONE ACETATE reactions: Congenital prolonged QT syndrome type 2 serious: 1 patientsex: 1 drugs: ASPIRIN, AZITHROMYCIN ANHYDROUS, CEFTRIAXONE, DILTIAZEM, ENOXAPARIN, FUROSEMIDE, METFORMIN HYDROCHLORIDE, METOPROLOL, PREDNISONE, RIVAROXABAN, TOPOL XL reactions: Acute respiratory failure, Hyperglycaemia serious: 1 patientsex: 2 drugs: FOLIC ACID, LEFLUNOMIDE, METHOTREXATE, METAMIZOLE, PANTOPRAZOLE SODIUM, SIMVASTATIN reactions: Acute kidney injury, ADAMTS13 activity decreased, Hepatic cirrhosis, Hepatic failure, Hepatic toxicity, Hypokalaemia, Hypovolaemia, Hypokalaemia, Hypokalaemia, Hypokalaemia, Hypokalaemia, Hypokalaemia, Hypokalaemia, Hypokalaemia, Hypokalaemia, Hypokalaemia, Hypokalaemia, Hypokalaemia, Hypokalaemia, Hypokalaemia, Hypokalaemia, Hypokalaemia, Hypokalaemia, Hypokalaemia, Hypokalaemia, Hypokalaemia, Hypokalaemia, Hypokalaemia, Hypokalaemia, Hypokalaemia, Hypokalaemia, Hypokalaemia, Hypokalaemia, Hypokalaemia, Hypokalaemia, Hypokalaemia, Hypokalaemia, Hypokalaemia, Hypokalaemia serious: 1 patientsex: 2 drugs: ADALIMUMAB, AZATHIOPRINE, METHOTREXATE reactions: Drug ineffective, Maternal exposure during pregnancy serious: 1 patientsex: 2 drugs: CYCLOSPORINE, METHYLPREDNISOLONE, PREDNISOLONE, SILDENAFIL reactions: Pseudocyst of pancreas serious: 1 patientsex: 1 drugs: ASPIRIN, ATORVASTATIN, CLOPIDOGREL BISULFATE, HEPARIN SODIUM, ISOSORBIDE MONONITRATE, METOPROLOL, NIFEDIPINE reactions: Gastrointestinal haemorrhage, Sepsis serious: 1 patientsex: 1 drugs: CISPLATIN, DOCETAXEL, FLUOROURACIL reactions: Drug ineffective serious: 1 patientsex: 1 drugs: CELECOXIB, CISPLATIN, IRINOTECAN reactions: Leukopenia serious: 1 patientsex: 1 drugs: AMITRIPTYLINE, ATORVASTATIN, CLOPIDOGREL BISULFATE, DEXAMETHASONE, THIMAMINE, RAMIPRIL reactions: Acute kidney injury, Drug interaction, Metabolic acidosis, Multiple organ dysfunction syndrome, Tumour lysis syndrome serious: 1 patientsex: 1 drugs: METHOTREXATE, METHYLPREDNISOLONE reactions: Central nervous system lymphoma, Diffuse large B-cell lymphoma, Epstein-Barr virus infection, Gastritis ulcerative, Lymphoproliferative disorder, Nausea, Neutropenia, Speech disorder serious: 1 patientsex: 2 drugs: AMPICILLIN SODIUMSULBACTAM SODIUM, CLINDAMYCIN, LINEZOLID, MEROPENEM, PREDNISOLONE, TACROLIMUS reactions: Disseminated phaeohyphomycosis, Haemoptysis, Respiratory failure serious: 1 patientsex: 1 drugs: AZITHROMYCIN ANHYDROUS, ETRAVIRINE, RALTEGRAVIR, SULFAMETHOXAZOLETRIMETHOPRIM reactions: Meningitis aseptic serious: 1 patientsex: 2 drugs: BEVACIZUMAB, CARBOPLATIN, DOCETAXEL, ERLOTINIB reactions: Fluid retention syndrome serious: 1 patientsex: 2 drugs: BENZTROPINE, LITHIUM, OLANZAPINE, QUETIAPINE, RISPERIDONE, VALPROIC ACID reactions: Alopecia, Affect disorder, Dizziness, Gait disturbance, Gait disturbance, Obsessive-compulsive disorder, Obsessive-compulsive behaviour, Obsessive-compulsive disorder, Somnolence, Social withdrawal syndrome, Somnolence serious: 1 patientsex: 2 drugs: CARBOPLATIN, FOLIC ACID, PEMETREXED reactions: Toxic epidermal necrolysis serious: 1 patientsex: 1 drugs: DENOSUMAB, METHOTREXATE, RADIUM RA-223 DICHLORIDE reactions: Prostatic specific antigen increased serious: 1 patientsex: 1 drugs: ASPIRIN, CLOPIDOGREL BISULFATE, WARFARIN reactions: Drug intolerance, Gastrointestinal haemorrhage serious: 1 patientsex: 1 drugs: ETHAMBUTOL HYDROCHLORIDE, ISONIAZID, PYRAZINAMIDE, RIFAMPIN reactions: Drug ineffective serious: 1 patientsex: 1 drugs: CALCHICHEL, CIPROFLOXACIN, IBANDRONIC ACID, PREDNISOLONE reactions: Atypical fracture, Condition aggravated, Drug interaction, Tendonitis serious: 1 patientsex: 1 drugs: BOVIDONE-IODINE, CIPROFLOXACIN, CIPROFLOXACIN HYDROCHLORIDE, CIPROFLOXACIN HYDROCHLORIDE, CIPROFLOXACIN HYDROCHLORIDE, CIPROFLOXACIN HYDROCHLORIDE, CIPROFLOXACIN HYDROCHLORIDE, CIPROFLOXACIN HYDROCHLORIDE, CIPROFLOXACIN HYDROCHLORIDE, CIPROFLOXACIN HYDROCHLORIDE, CIPROFLOXACIN HYDROCHLORIDE, CIPROFLOXACIN HYDROCHLORIDE, CIPROFLOXACIN HYDROCHLORIDE, CIPROFLOXACIN HYDROCHLORIDE, CIPROFLOXACIN HYDROCHLORIDE, CIPROFLOXACIN HYDROCHLORIDE, CIPROF serious: 1 patientsex: 1 drugs: CLONIDINE, FLUVOXAMINE, LINEZOLID, MIDAZOLAM HYDROCHLORIDE, SERTRALINE HYDROCHLORIDE reactions: Serotonin syndrome serious: 1 patientsex: 1 drugs: BORTEZOMIB, DEXAMETHASONE, LENALIDOMIDE reactions: COVID-19 serious: 1 patientsex: 2 drugs: ALENDAZOLE, DECLARAZINE, IVERMECTIN reactions: Drug ineffective, Off label use serious: 1 patientsex: 2 drugs: ATENOLOL, COLCHICINE, CYCLOSPORINE, MYCOPHENOLATE MOFETIL, PREDNISOLONE reactions: Gingival disorder, Periodontitis, Tooth loss serious: 1 patientsex: 1 drugs: POTASSIUM IODIDE reactions: Hypothyroidism serious: 1 patientsex: 2 drugs: CLINDAMYCIN, METRONIDAZOLE, METFORMIN HYDROCHLORIDE, VANCOMYCIN reactions: Clogged ears, Drug level increased, Ototoxicity serious: 1 patientsex: 1 drugs: ACETAZOLAMIDE, METHYLPREDNISOLONE, MOXIFLOXACIN, PREDNISOLONE ACETATE, PILOCARPINE reactions: Ocular hypertension serious: 1 patientsex: 1 drugs: BUSULFAN, FLUDARABINE PHOSPHATE, LEVOFLOXACIN, MYCOPHENOLATE MOFETIL, TACROLIMUS reactions: Mucormycosis serious: 1 patientsex: 1 drugs: MEROPENEM, TIGECYCLINE reactions: Drug ineffective serious: 1 patientsex: 1 drugs: CEFAZOLIN reactions: Acute kidney injury, Proteinuria, Tubulointerstitial nephritis serious: 1 patientsex: 1 drugs: MEROPENEM reactions: Clostridium difficile colitis, Intestinal stenosis serious: 1 patientsex: 1 drugs: ADALIMUMAB, ETANERCEPT, LEFLUNOMIDE, METHOTREXATE, PREDNISONE, SULFAMETHOXAZOLETRIMETHOPRIM reactions: Drug ineffective, Whipples disease serious: 1 patientsex: 2 drugs: AMPICILLIN, BETAMETHASONE, AZITHROMYCIN ANHYDROUS, OXYTOCIN reactions: Foetal exposure during pregnancy, Low birth weight baby, Premature baby serious: 1 patientsex: 2 drugs: DONEPEZIL, TAMSULOSIN reactions: Drug interaction serious: 1 patientsex: 1 drugs: TACROLIMUS reactions: Cholangitis, Synovial sarcoma serious: 1 patientsex: 1 drugs: APIXABAN, ATORVASTATIN, ENOXAPARIN, METOPROLOL reactions: Atrioventricular block, Haemorrhagic shock, Loss of consciousness, Supraventricular tachycardia serious: 1 patientsex: 2 drugs: FLUOROURACIL, OXALIPLATIN reactions: Coronary artery vasoconstriction serious: 1 patientsex: 1 drugs: FENTANYL, ISOFLURANE, PROPOFOL, SUCCINYLCHOLINE reactions: Malignant hyperthermia serious: 1 patientsex: 1 drugs: ENTECAVIR, TENOFOVIR DISOPROXIL FUMARATE reactions: Hepatitis B reactivation serious: 1 patientsex: 1 drugs: ACYCLOVIR, CEFOTAXIME SODIUM, LEVOFLOXACIN, PIPERACILLIN SODIUMTAZOBACTAM SODIUM, VANCOMYCIN reactions: Drug ineffective serious: 1 patientsex: 1 drugs: DEXAMETHASONE, LENALIDOMIDE, PREDNISOLONE reactions: Disseminated intravascular coagulation, Septic shock serious: 1 patientsex: 2 drugs: ALPRAZOLAM, FLUOXETINE HYDROCHLORIDE, METHYLPHENIDATE HYDROCHLORIDE reactions: Aggression, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation serious: 1 patientsex: 2 drugs: BEVACIZUMAB, CYCLOPHOSPHAMIDE, EPIRUBICIN, FULVESTRANT, EVEROLIMUS, PACLITAXEL, TRIPTORELIN, TAMOXIFEN reactions: Breast cancer metastatic, Cough, Dyspnoea, Pleural effusion, Pleural infiltration, Pulmonary opacities, Pulmonary infiltration, Pleural effusion, Pulmonary infiltration, Pulmonary infiltration, Pleural effusion, Pulmonary infiltration, Pulmonary infiltration, Pleural effusion, Pulmonary infiltration, Pulmonary infiltration, Pleural effusion, Pulmonary infiltration, Pulmonary infiltration, Pleural effusion, Pulmonary infiltration, Pleural effusion, Pulmonary infiltration, Pulmonary infiltration, Pulmonary infiltration, Pleural effusion, Pulmonary infiltration, Pleural effusion, Pulmonary infiltration, Pleural effusion, Pulmonary infiltration, Pleural effusion, Pulmonary infiltration, Pleural effusion, Pul serious: 1 patientsex: 2 drugs: CARBOPLATIN, PACLITAXEL reactions: Anaphylactic reaction serious: 1 patientsex: 2 drugs: CYCLOPHOSPHAMIDE, CYTARABINE, ETOPOSIDE, MERCAPTOPURINE, METHOTREXATE, NELARABINE, VINCRISTINE reactions: Acute graft versus host disease, Chronic graft versus host disease, Pneumonitis, Seizure, Serositis serious: 1 patientsex: 1 drugs: MITOMYCIN reactions: Urethro-cavernosal-spongiosal fistula serious: 1 patientsex: 1 drugs: VORICONAZOLE reactions: Cholestasis, Drug-induced liver injury, Hypertransaminasaemia serious: 1 patientsex: 1 drugs: METHOTREXATE reactions: Leukopenia serious: 1 patientsex: 1 drugs: ALCOHOL reactions: Atrial fibrillation, Nocardiosis, Pulmonary nodule, Right ventricular dysfunction, Pericardial effusion, Respiratory distress, Right ventricular dysfunction, Pericardial tamponade, Respiratory distress serious: 1 patientsex: 1 drugs: CALCIUM, CHOLECALCIFEROL, METHOTREXATE, OMEPRAZOLE, PREDNISOLONE reactions: Crohns disease serious: 1 patientsex: 2 drugs: PREDNISOLONE reactions: Drug-induced psychotic disorder serious: 1 patientsex: 1 drugs: AMOXICILLIN, CLAVULANIC ACID, OLANZAPINE, TOPIRAMATE reactions: Graft site necrosis, Postoperative wound infection serious: 1 patientsex: 2 drugs: ATEZOLIZUMAB, PACLITAXEL reactions: COVID-19 pneumonia, Staphylococcal infection serious: 1 patientsex: 2 drugs: CARBOPLATIN, CISPLATIN, DOCETAXEL reactions: Drug interaction, Inappropriate schedule of drug administration, Intentional product use issue, Product use issue serious: 1 patientsex: 1 drugs: HEPARIN SODIUM, ERTAPENEM SODIUM reactions: Off label use serious: 1 patientsex: 2 drugs: DOCETAXEL, GEMCITABINEGEMCITABINE HYDROCHLORIDE reactions: Anaemia, Decreased appetite, Diarrhoea, Fatigue, Neutropenia, Weight decreased, Vomiting serious: 1 patientsex: 1 drugs: CYCLOPHOSPHAMIDE, PREDNISONE, RITUXIMAB, VINCRISTINE reactions: Hepatic failure, Hepatitis B reactivation serious: 1 patientsex: 1 drugs: POLYMYXIN B reactions: Cognitive disorder, Neurotoxicity serious: 1 patientsex: 2 drugs: LAMOTRIGINE, PHENOBARBITAL, RISPERIDONE, TIGABINE, VALPROIC ACID reactions: Drug interaction, Drug level decreased, Drug level increased, Drug level increased, Drug level decreased, Drug level increased, Drug level decreased, Drug level increased, Drug level decreased, Drug level increased, Drug level decreased, Drug level increased, Drug level decreased, Drug level increased, Drug level decreased, Drug level increased, Drug level decreased, Drug level increased, Drug level decreased, Drug level increased, Drug level decreased, Drug level increased, Drug level decreased, Drug level increased, Drug level decreased, Drug level increased, Drug level decreased, Drug level increased, Drug level decreased, Drug level increased, Drug level decreased, Drug level increased, Drug level decreased, Drug level increased, Drug level decreased, Drug level increased, Drug level decreased, Drug level increased, Drug level decreased, Drug level increased, Drug level decreased, Drug level increased, Drug level decreased, Drug level increased, Drug level decreased, Drug level increased, Drug level decreased, Drug level increased, Drug level decreased, Drug level increased, Drug level decreased, Drug level increased, Drug level decreased, Drug level serious: 1 patientsex: 1 drugs: INFLIXIMAB, MESALAMINE reactions: Pulmonary embolism serious: 1 patientsex: 2 drugs: VENLAFAXINE HYDROCHLORIDE reactions: Galactorrhoea serious: 1 patientsex: 1 drugs: DALFAMPRIDINE, TYSABRINOL, TEMAZEPAM, VALACYCLOVIR HYDROCHLORIDE reactions: Epilepsy, Overdose, Seizure serious: 1 patientsex: 2 drugs: DAPSONE, BLINATUMOMAB, CYCLOPHOSPHAMIDE, CYTARABINE, DOXORUBICIN, MERCAPTOPURINE, METHOTREXATE, PREDNISONE, VINCRISTINE reactions: Hyperkalaemia, Renal failure serious: 1 patientsex: 1 drugs: CLONAZEPAM, LEVETIRACETAM, PIRACETAM, VALPROIC ACID reactions: Drug ineffective serious: 1 patientsex: 2 drugs: PIPERACILLIN SODIUMTAZOBACTAM SODIUM, TOBRAMYCIN reactions: Drug reaction with eosinophilia and systemic symptoms serious: 1 patientsex: 1 drugs: CYCLOSPORINE, IMATINIB MESYLATE reactions: Chloroma serious: 1 patientsex: 1 drugs: ALLOPURINOL, AMLODIPINE BESYLATE, CANRENOIC ACID, FUROSEMIDE, IRBESARTAN, HYDROXYZINE HYDROCHLORIDE, PEGINTERFERON ALFA-2A, SPIRONOLACTONE, TOLVAPTAN reactions: Blood creatinine increased, Blood urea increased, Blood urea nitrogen increased, Blood urea increased, Blood urea nitrogen decreased, Blood urea nitrogen increased, Blood urea nitrogen increased, Blood urea nitrogen increased, Blood urea nitrogen decreased, Blood urea nitrogen increased, Blood urea nitrogen increased, Blood urea nitrogen decreased, Blood urea nitrogen increased, Blood urea nitrogen increased, Blood urea nitrogen decreased, Blood urea nitrogen increased, Blood urea nitrogen increased, Blood urea nitrogen decreased, Blood urea nitrogen increased, Blood urea nitrogen increased, Blood urea nitrogen decreased, Blood urea nitrogen increased, Blood urea nitrogen increased, Blood urea nitrogen decreased, Blood urea nitrogen serious: 1 patientsex: 1 drugs: METRONIDAZOLE reactions: Hepatic abscess serious: 1 patientsex: 2 drugs: CARBOPLATIN, PACLITAXEL reactions: Infusion related reaction, Neuropathy peripheral, Transaminases increased serious: 1 patientsex: 2 drugs: BOSENTAN, SILDENAFIL reactions: Atrial septal defect, Pulmonary arterial hypertension serious: 1 patientsex: 1 drugs: BUDESONIDE, BUSULFAN, FLUDARABINE PHOSPHATE, TACROLIMUS reactions: Anaphylactic reaction, Drug hypersensitivity, Hypotension, Respiratory distress, Vomiting serious: 1 patientsex: 2 drugs: PANTOPRAZOLE SODIUM reactions: Anaphylactic reaction serious: 1 patientsex: 1 drugs: CISPLATIN, FLUOROURACIL reactions: Retinal detachment serious: 1 patientsex: 2 drugs: CLOBAZAM, CARBAMAZEPINE, DIAZEPAM, LAMOTRIGINE, LEVETIRACETAM, PERAMPANEL reactions: Drug ineffective, Epilepsy, Drug noncompliance, Drug level below therapeutic, Drug level below therapeutic, Epilepsy, Drug level below therapeutic, Drug level above therapeutic, Epilepsy, Drug level below therapeutic, Epilepsy, Epilepsy, Drug level below therapeutic, Epilepsy, Epilepsy, Drug level below therapeutic, Epilepsy, Epilepsy, Drug level below therapeutic, Epilepsy, Epilepsy, Epilepsy, Drug level below therapeutic, Epilepsy, Epilepsy, Epilepsy, Epilepsy, Epilepsy, Epilepsy, Epilepsy, Epilepsy, Epilepsy, Epilepsy, Epilepsy, Epilepsy, Epilepsy, Epilepsy, Epilepsy, Epilepsy, Epilepsy, Epilepsy, Epilepsy, Epilepsy, Epilepsy, Epilepsy, Epilepsy, Epilepsy, Epilepsy, Epilepsy, Epile serious: 1 patientsex: 2 drugs: EVEROLIMUS, SUNITINIB MALATE reactions: Cardiac failure congestive, Mucosal inflammation, Palmar-plantar erythrodysaesthesia syndrome serious: 1 patientsex: 2 drugs: CYCLOSPORINE, CYTARABINE, ETOPOSIDE, METHOTREXATE, VINCRISTINE reactions: Cachexia, Depressive disorder, Malabsorption, Osteoporosis, Maternal exposure during pregnancy, Maternal exposure during pregnancy, Maternal exposure during pregnancy, Osteonecrosis, Premature delivery, Premature labour, Premature delivery, Premature labour, Premature delivery, Premature labour, Premature delivery, Premature labour, Premature delivery, Premature labour, Premature delivery, Premature labour, Premature delivery, Premature labour, Premature labour, Premature delivery, Premature labour, Premature labour, Premature labour, Premature labour, Premature labour, Premature labour, Premature labour, Premature labour, Premature labour, Premature labour, Premature labour, Premature labour, Premature labour, Premature labour, Premature labour, Premature labour, Premature labour, serious: 1 patientsex: 2 drugs: AMIODARONE HYDROCHLORIDE reactions: Drug ineffective serious: 1 patientsex: 2 drugs: NITROUS OXIDE reactions: Vitamin B12 deficiency serious: 2 patientsex: 2 drugs: FLUNITRAZEPAM reactions: Drug ineffective serious: 1 patientsex: 2 drugs: AZATHIOPRINE, HUMAN IMMUNOGLOBULIN G, PREDNISOLONE, RITUXIMAB reactions: Generalised epilepsy, Off label use, Product use in unapproved indication serious: 1 patientsex: 1 drugs: METHOTREXATE, PREDNISONE reactions: Pneumocystis jirovecii pneumonia serious: 1 patientsex: 1 drugs: CARBOPLATIN, GEMCITABINEGEMCITABINE HYDROCHLORIDE reactions: Oesophageal fistula serious: 1 patientsex: 2 drugs: DENOSUMAB, LETROZOLE, ZOLEDRONIC ACID reactions: Atypical femur fracture, Joint pain, Toxicity to various agents serious: 1 patientsex: 1 drugs: METHOTREXATE, METHYLPREDNISOLONE reactions: Drug ineffective serious: 1 patientsex: 2 drugs: ARIPIPRAZOLE, CLONAZEPAM, OLANZAPINE, PALIPERIDONE reactions: Akathisia, Drug ineffective, Extrapyramidal disorder, Self-mutilation serious: 1 patientsex: 2 drugs: CHLOROQUINE SULFATE reactions: Retinal degeneration, Retinal disorder, Retinal degeneration, Retinal depigmentation, Retinal degeneration, Retinal disorder, Retinal degeneration, Retinal disorder, Retinal degeneration, Retinal disorder, Retinal disorder, Retinal degeneration, Retinal disorder, Retinal disorder, Retinal disorder, Retinal disorder, Retinal disorder, Retinal disorder, Retinal disorder, Retinal disorder, Retinal disorder, Retinal disorder, Retinal disorder, Retinal disorder, Retinal disorder, Retinal disorder, Retinal disorder, Retinal disorder, Retinal disorder, Retinal disorder, Retinal disorder, Retinal disorder, Retinal disorder, Retinal disorder, Retinal disorder, Retinal disorder, Retinal disorder, Retinal disorder, Retinal disorder, Retinal disorder, Retinal disorder, Retinal disorder, Retinal disorder, Retinal disorder, Retinal disorder, Re serious: 1 patientsex: 2 drugs: HUMAN IMMUNOGLOBULIN G, METHYLPREDNISOLONE, SULFASALAZINE reactions: Drug reaction with eosinophilia and systemic symptoms, Epstein-Barr virus infection serious: 1 patientsex: 1 drugs: SORAFENIB reactions: Hepatic enzyme increased serious: 1 patientsex: 1 drugs: CISPLATIN reactions: Abdominal pain, Meningitis bacterial, Sepsis serious: 1 patientsex: 2 drugs: LEUPROLIDE ACETATE reactions: Off label use serious: 1 patientsex: 2 drugs: ASPIRIN, HEPARIN SODIUM reactions: Abortion spontaneous, Catastrophic antiphospholipid syndrome, Drug ineffective, Exposure during pregnancy, Renal failure serious: 1 patientsex: 2 drugs: CYCLOPHOSPHAMIDE, DOXORUBICIN, PREDNISOLONE, RITUXIMAB, VINCRISTINE reactions: Diffuse large B-cell lymphoma, Pancytopenia serious: 1 patientsex: 2 drugs: AFATINIB, DEXAMETHASONE reactions: Diarrhoea, Rash serious: 1 patientsex: 1 drugs: CEFTRIAXONE, METOPROLOL, PENICILLIN G, VANCOMYCIN reactions: Cerebral artery thrombosis, Cerebral infarction, Cerebral artery thrombosis, Cerebral artery thrombosis, Cerebral infarction, Cerebral artery thrombosis, Cerebral infarction, Cerebral artery thrombosis, Cerebral infarction, Cerebral artery thrombosis, Cerebral infarction, Cerebral artery thrombosis, Cerebral infarction, Cerebral artery thrombosis, Cerebral infarction, Cerebral artery thrombosis, Cerebral infarction, Cerebral infarction, Cerebral artery thrombosis, Cerebral infarction, Cerebral infarction, Cerebral infarction, Cerebral serious: 1 patientsex: 2 drugs: ALENDAZOLE, DAPHTHYLCARBAMAZEPINE, IVERMECTIN reactions: Abdominal pain, Dizziness, Fatigue, Headache, Nausea, Pyrexia, Rash serious: 1 patientsex: 1 drugs: LINEZOLID, CLINDAMYCIN, IMIPENEM, VANCOMYCIN reactions: Drug ineffective serious: 1 patientsex: 1 drugs: ALTEPLASE reactions: Ischaemic stroke serious: 1 patientsex: 1 drugs: ASPIRIN, CLOPIDOGREL BISULFATE reactions: Carotid artery stenosis serious: 1 patientsex: 1 drugs: ETOMIDATE, OXYCODONE, REMIFENTANIL, ROCURONIUM BROMIDE, SEVOFLURANE reactions: Haemodynamic instability, Haemorrhage, Hypotension, Post procedural haemorrhage serious: 1 patientsex: 1 drugs: CYCLOSPORINE, MYCOPHENOLIC ACID reactions: Atypical mycobacterium infection, Actinic keratosis, Porokeratosis, Skin lesion serious: 1 patientsex: 1 drugs: DOXORUBICIN, ETOPOSIDE, IFOSFAMIDE, VINCRISTINE reactions: Bone marrow failure serious: 1 patientsex: 2 drugs: EPINEPHRINE, DOPAMINEDOPAMINE HYDROCHLORIDE, NOREPINEPHRINE, PROMETHAZINE HYDROCHLORIDE reactions: Acute myocardial infarction, Stress cardiomyopathy serious: 1 patientsex: 2 drugs: BEVACIZUMAB, DOCETAXEL, PACLITAXEL, NOREPINEPHRINE reactions: Intestinal perforation, Pyrexia, Subileus serious: 1 patientsex: 2 drugs: FLUOROURACIL, LEUCOVORIN, OXALIPLATIN reactions: Bone marrow failure serious: 1 patientsex: 2 drugs: AZITHROMYCIN ANHYDROUS, CEFTAZIDIME, CEFTRIAXONE, HYDROXYCHLOROQUINE, LEVOFED, MAGNESIUM, REMDESIVIR, TOCILIZUMAB reactions: Drug ineffective serious: 1 patientsex: 2 drugs: FUROSEMIDE, NITROPRUSSIDE reactions: Exposure during pregnancy serious: 1 patientsex: 2 drugs: AMLODIPINE BESYLATE, HYDROCORTISONE, METFORMIN HYDROCHLORIDE, TRIAMCINOLONE reactions: Adrenal insufficiency, Drug hypersensitivity, Hypertension serious: 1 patientsex: 2 drugs: DAPSONE, MYCOPHENOLATE MOFETIL, TACROLIMUS, VALGANCICLOVIR reactions: Chills, Disseminated tuberculosis, Thyroid tuberculosis serious: 1 patientsex: 1 drugs: VENLAFAXINE HYDROCHLORIDE reactions: Hypertensive encephalopathy serious: 1 patientsex: 2 drugs: AFATINIB reactions: Malignant neoplasm progression serious: 1 patientsex: 1 drugs: IPILIMUMAB, NIVOLUMAB, ZOLEDRONIC ACID reactions: Decreased appetite, Diarrhoea, Hepatic function abnormal, Nausea, Rash serious: 1 patientsex: 1 drugs: MYCOPHENOLIC ACID, PREDNISONE, TACROLIMUS reactions: Neoscytalidium infection serious: 1 patientsex: 2 drugs: AMLODIPINE BESYLATE reactions: Acute kidney injury, Hypotension, Overdose, Sinus tachycardia serious: 1 patientsex: 1 drugs: ATORVASTATIN, CITALOPRAM HYDROBROMIDE, HYDROCHLOROTHIAZIDE, LORAZEPAM, METOPROLOL reactions: Haemorrhage intracranial, Toxicity to various agents serious: 1 patientsex: 2 drugs: HYDROCORTISONE, KETOCONAZOLE, METYALPONE reactions: Adrenocorticotropic hormone syndrome, Drug ineffective, Off label use serious: 1 patientsex: 1 drugs: METHIMAZOLE, METOPROLOL, PREDNISONE reactions: Gastrointestinal disorder, Hyperthyroidism serious: 1 patientsex: 2 drugs: CYCLOPHOSPHAMIDE, LETROZOLE, SORAFENIB reactions: Diarrhoea, Rash serious: 1 patientsex: 2 drugs: BETAMETHASONE, CEFAZOLIN, ATEOSIBAN, BEMIPARINE, CEFAZOLIN, MAGNESIUM SULFATE reactions: Foetal exposure during pregnancy, Low birth weight baby, Premature baby serious: 1 patientsex: 1 drugs: DEXAMETHASONE reactions: Adrenal hyperplasia, Adrenal hyperplasia, Adrenal hyperplasia, Adrenal hyperplasia, Adrenal hypertension, Adrenal hyperplasia, Adrenal hyperplasia, Adrenal hypertension, Adrenal hyperplasia, Adrenal hypertension, Adrenal hyperplasia, Adrenal hypertension, Adrenal hyperplasia, Adrenal hyperplasia, Adrenal hyperplasia, Adrenal hyperplasia, Adrenal hypertension, Adrenal hyperplasia, Adrenal hypertension, Adrenal hyperplasia, Adrenal hypertension, Adrenal hyperplasia, Adrenal hypertension, Adrenal hyperplasia, Adrenal hypertension, Adrenal hyperplasia, Adrenal hypertension, Adrenal hyperplasia, Adrenal hypertension, Adrenal hyperplasia, Adrenal hypertension, Adrenal hyperplasia, Adrenal hypertension, serious: 1 patientsex: 1 drugs: CEFTRIAXONE reactions: Jarisch-Herxheimer reaction serious: 1 patientsex: 2 drugs: AMIKACIN, AMPHOTERICIN B, AMPHOTERICIN C, CEFUROXIME, IMIPENEM, MEROPENEM, PIPERACILLIN SODIUMTAZOBACTAM SODIUM, VANCOMYCIN reactions: Clostridium difficile infection, Drug resistance serious: 1 patientsex: 1 drugs: ARIPIPRAZOLE, BUDESONIDE, CYCLOPHOSPHAMIDE, HUMAN IMMUNOGLOBULIN G, METHYLPREDNISOLONE, PREDNISOLONE, RITUXIMAB, VINCRISTINE reactions: Drug ineffective, Drug withdrawal syndrome, Status epilepticus serious: 1 patientsex: 1 drugs: DEXAMETHASONE, INSULIN NOS, MANNITOL reactions: Drug ineffective, Growth hormone decreased serious: 1 patientsex: 1 drugs: IMATINIB MESYLATE reactions: Anorexia, Decreased appetite, Nausea, Renal impairment, Tuberculosis serious: 1 patientsex: 2 drugs: ASPIRIN, CLOPIDOGREL BISULFATE reactions: Accidental exposure to product, Headache, Ecchymosis, Multiple organ dysfunction syndrome, Retropharyngeal haematoma, Respiratory disorder serious: 1 patientsex: 1 drugs: CYCLOPHOSPHAMIDE, DOXORUBICIN, ETOPOSIDE, METHOTREXATE, PREDNISONE, RITUXIMAB, VINCRISTINE reactions: Blood 25-hydroxycholecalciferol decreased, Blood 25-hydroxycholecalciferol increased, Blood 25-dihydroxycholecalciferol decreased, Blood 25-dihydroxycholecalciferol increased, Blood 25-dihydroxycholecalciferol increased, Blood 25-dihydroxycholecalciferol decreased, Blood 25-dihydroxycholecalciferol increased, Blood 25-dihydroxycholecalciferol increased, Blood 25-dihydroxycholecalciferol decreased, Blood 25-dihydroxycholecalciferol increased, Blood 25-dihydroxycholecalciferol increased, Blood 25-dihydroxycholecalciferol decreased, Blood 25-dihydroxycholecalciferol increased, Blood 25-dihydroxycholecalciferol decreased, Blood 25-dihydroxychol serious: 1 patientsex: 1 drugs: AZATHIOPRINE, PREDNISOLONE reactions: Intestinal obstruction, Necrotising fasciitis, Septic shock serious: 1 patientsex: 1 drugs: HALOPERIDOL DECANOATE, QUETIAPINE FUMARATE reactions: Acute kidney injury, Rhabdomyolysis serious: 1 patientsex: 2 drugs: AMLODIPINE BESYLATE, CALCIUM, CILAZEPAIL, FOLIC ACID, ERYTHROPOIETIN, IRON, VALSARTAN reactions: Foetal exposure during pregnancy, Premature baby serious: 1 patientsex: 2 drugs: HYDROXYCHLOROQUINE, METHOTREXATE, PREDNISOLONE reactions: Erythroderma serious: 1 patientsex: 2 drugs: BUPIVACAINE, CEFAZOLIN, EPHEDRINE, FENTANYL, MORPHINE, PROPOFOL reactions: Confusional state serious: 1 patientsex: 2 drugs: BETAMETHASONE PHOSPHATE, TRIAMCINOLONE ACETONIDE reactions: Osteonecrosis serious: 1 patientsex: 1 drugs: AMIODARONE, APIXABAN reactions: Pneumonitis, Toxicity to various agents serious: 1 patientsex: 2 drugs: LEVETIRACETAM, OLANZAPINE, TOPIRAMATE reactions: Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation, Agitation serious: 1 patientsex: 1 drugs: AMBRISENTAN, BOSENTAN, SIROLIMUS, TREPROSTINIL reactions: Hepatic function abnormal, Pulmonary oedema serious: 1 patientsex: 1 drugs: PREDNISOLONE reactions: Adrenal suppression, Immunosuppression, Necrotising fasciitis, Sepsis serious: 1 patientsex: 2 drugs: ATORVASTATIN, EZETIMIBE, HYDROCHLOROTHIAZIDE, IRBESARTAN, RABEPRAZOLE, TAMOXIFEN reactions: Generalised tonic-clonic seizure, Hyponatraemia, Hypokalaemia serious: 1 patientsex: 2 drugs: CARBOPLATIN, DOXORUBICIN, ETOPOSIDE, PACLITAXEL, PREDNISOLONE, WARFARIN reactions: Anaphylactic reaction, Deep vein thrombosis, Pericardial effusion, Pulmonary embolism, Pericardial haemorrhage serious: 1 patientsex: 2 drugs: BUPIVACAINE, CEFAZOLIN SODIUM, ENOXAPARIN SODIUM, FENTANYL, ISOFLURANE, LIDOCAINE, METOCLOPRAMIDE, RANITIDINE, OXYTOCIN, OXYGEN, OXYGEN TOCIN HYDROCHLORIDE, OXYTOCIN SULFATE, PROPOFOL reactions: Acute chest syndrome, Bradycardia, Hypotension, Maternal exposure during pregnancy, Vasoocclusive crisis serious: 1 patientsex: 1 drugs: ANAKINRA reactions: Drug ineffective, Off label use serious: 1 patientsex: 1 drugs: IMATINIB MESYLATE reactions: Hepatitis B reactivation serious: 1 patientsex: 1 drugs: ADEFOVIR, ENTECAVIR, LAMIVUDINE, PREDNISOLONE, TACROLIMUS reactions: Drug resistance, Hepatitis B serious: 1 patientsex: 1 drugs: ATORVASTATIN, METHYLPREDNISOLONE, PREDNISOLONE reactions: Drug ineffective, Myositis autoimmune serious: 1 patientsex: 2 drugs: IPILIMUMAB reactions: Meningoencephalomyelitis serious: 1 patientsex: 2 drugs: HYDROXYCHLOROQUINE reactions: Retinopathy serious: 1 patientsex: 2 drugs: BEVACIZUMAB, PACLITAXEL, TRASTUZUMAB reactions: Disease progression, Drug ineffective, Inflammation, Metastases to bone, Metastases to pelvis, Metastases to liver, Metastases to pelvis, Metastases to bone, Metastases to pelvis, Metastases to bone, Metastases to pelvis, Metastases to bone, Metastases to pelvis, Metastases to bone, Metastases to pelvis, Metastases to pelvis, Metastases to pelvis, Metastases to pelvis, Metastases to pelvis, Metastases to pelvis, Metastases to pelvis, Metastases to pelvis, Metastases to pelvis, Metastases to pelvis, Metastases to pelvis, Metastases to pelvis, Metastases to pelvis, Metastases to pelvis, Metastases to pelvis, Metastases to pelvis, Metastases to pelvis, Metastases to pelvis, Metastases to pelvis, Metastases to pelvis, Metasta serious: 1 patientsex: 1 drugs: CARBAMAZEPINE, CLOBAZAM, CLONAZEPAM, GLICLAZIDE, LACOSAMIDE, LEVETIRACETAM, LISINOPRIL, METFORMIN HYDROCHLORIDE, MIDAZOLAM HYDROCHLORIDE, PHENOBARBITAL, PHENYTOIN, PREDNISOLONE, TOPIRAMATE, VALPROIC ACID reactions: Drug ineffective, Rash serious: 1 patientsex: 2 drugs: CARBAMAZEPINE, CLOBAZAM, EPINEPHRINE, LEVETIRACETAM, PHENYTOIN, PROPOFOL, REMIFENTANIL, VALPROIC ACID reactions: Bradycardia, Bundle branch block right, Drug ineffective, Hypertriglyceridaemia, Lactic acidosis, Renal failure, Status epilepticus serious: 1 patientsex: 1 drugs: CISPLATIN reactions: Stomatitis, Vomiting serious: 1 patientsex: 2 drugs: CISPLATIN, DOCETAXEL, FLUOROURACIL reactions: Death, Toxicity to various agents serious: 1 patientsex: 2 drugs: TERIPARATIDE reactions: Bone marrow failure, Off label use, Product use in unapproved indication serious: 1 patientsex: 2 drugs: GENTAMICIN SULFATE reactions: Retinal haemorrhage, Retinal vein occlusion serious: 1 patientsex: 2 drugs: METHYLPREDNISOLONE, MIDAZOLAM HYDROCHLORIDE reactions: Cerebral artery infarction, Epilepsy, Intracranial hypertension, Venous sinus thrombosis serious: 1 patientsex: 2 drugs: CISPLATIN, PACLITAXEL reactions: Haematotoxicity serious: 1 patientsex: 2 drugs: DROSPIRENONEETHINYL ESTRADIOLDROSPIRIN HYDROCHLORIDE, RIVAROXABAN reactions: Deep vein thrombosis, Pulmonary embolism serious: 1 patientsex: 1 drugs: CLOPIDOGREL BISULFATE reactions: Neovascular glaucoma serious: 1 patientsex: 1 drugs: AZATHIOPRINE reactions: Acute hepatic failure, Hepatic enzyme increased, Hepatic failure acute, Hepatic enzyme increased, Hepatic failure acute, Hepatic enzyme increased, Hepatic failure acute, Hepatic failure acute, Hepatic failure acute, Hepatic failure acute, Hepatic failure acute, Hepatic failure acute, Hepatic failure acute, Hepatic failure acute, Hepatic failure acute, Hepatic failure acute, Hepatic failure acute, Hepatic failure acute, Hepatic failure acute, Hepatic failure acute, Hepatic failure acute, Hepatic failure acute, Hepatic failure acute, Hepatic failure acute, Hepatic failure acute, Hepatic failure acute, Hepatic failure acute, Hepatic failure acute, Hepatic failure acute, Hepatic failure acute, Hepatic failure acute, Hepatic failure acute, Hepatic failure acute, Hepatic failure acute, Hepatic failure acute, Hepatic failure acute, Hepatic failure acute, Hepatic failure acute, Hepatic failure acute, Hepati serious: 1 patientsex: 1 drugs: METHOTREXATE, PREDNISONE, TOFACITINIB CITRATE reactions: Drug ineffective, Drug interaction, Hypertension, Nausea, Oedema peripheral, Oedema peripheral, Oedema peripheral, Oedema peripheral, Oedema peripheral, Oedema peripheral, Oedema peripheral, Oedema peripheral, Oedema peripheral, Oedema peripheral, Oedema peripheral, Oedema peripheral, Oedema peripheral, Oedema peripheral, Oedema peripheral, Oedema peripheral, Oedema peripheral, Oedema peripheral, Oedema peripheral, Oedema peripheral, Oedema peripheral, Oedema peripheral, Oedema peripheral, Oedema peripheral, Oedema peripheral, Oedema peripheral, Oedema peripheral, Oedema peripheral, Oedema peripheral, Oedema peripheral, Oedema peripheral, Oedema peripheral, Oedema peripheral, Oedema peripheral, Oedema serious: 1 patientsex: 2 drugs: IOHEXOL reactions: Anaphylactic reaction serious: 1 patientsex: 2 drugs: CYCLOSPORINE, METHOTREXATE, PREDNISOLONE reactions: Drug ineffective, Off label use serious: 1 patientsex: 1 drugs: ALLOPURINOL, CALCITRIOL, CHOLECALCIFEROL, CYCLOSPORINE, DILTIAZEM, IRBESARTAN, METOPROLOL, PREDNISOLONE reactions: Anaemia, Gastritis, Metaplasia, Non-Hodgkins lymphoma, Off label use, Product use in unapproved indication serious: 1 patientsex: 2 drugs: ACETATE SODIUM, ACETATE SODIUM BETA, ACETATE SODIUM CHLORIDE, ACETATE SODIUM PHOSPHATE, ACETATE SODIUM BETA, ACETATE SODIUM CHLORIDE, ACETATE SODIUM PHOSPHATE, ACETATE SODIUM PHOSPHATE, ACETATE SODIUM PHOSPHATE, ACETATE SODIUM PHOSPHATE, ACETATE SODIUM PHOSPHATE, ACETATE SODIUM PHOSPHATE, ACETATE SODIUM PHOSPHATE, ACETATE SODIUM PHOSPHATE, ACETATE SODIUM PHOSPHATE, ACETATE SODIUM PHOSPHATE, ACETATE SODIUM PHOSPHATE, ACETATE SODIUM PHOSPHATE, ACETATE SODI serious: 1 patientsex: 1 drugs: AMPHOTERICIN B, CANDNEPOL, FLUCONAZOLE reactions: Drug resistance serious: 1 patientsex: 1 drugs: FINASTERIDE reactions: Breast cancer serious: 1 patientsex: 2 drugs: BENZHEXOL, FLUOXETINE HYDROCHLORIDE, HALOPERIDOL, MONOPOLOL, SODIUM VALPROATE, TRANCODOL HYDROCHLORIDE reactions: Burning mouth syndrome serious: 1 patientsex: 1 drugs: AZITHROMYCIN ANHYDROUS, CEFTRIAXONE, HYDROXYCHLOROQUINE, PANTOPRAZOLE SODIUM reactions: Acute kidney injury, Metabolic acidosis, Respiratory failure, Upper gastrointestinal perforation serious: 1 patientsex: 1 drugs: DIPHENHYDRAMINE, LAMIVUDINE, SODIUM CHLORIDE, TEMISIROLIMUS reactions: Hepatic enzyme increased, Hepatic failure, Hepatic enzyme increased, Hyponatraemia, Neutropenia, Thrombocytopenia serious: 1 patientsex: 1 drugs: AMIKACIN, MEROPENEM, SULFAMETHOXAZOLETRIMETHOPRIM, VANCOMYCIN reactions: Drug ineffective serious: 1 patientsex: 2 drugs: SULFAMETHOXAZOLETRIMETHOPRIM reactions: Neutropenia, Thrombocytopenia serious: 1 patientsex: 2 drugs: NIVOLUMAB reactions: Vitiligo serious: 1 patientsex: 1 drugs: METHYLPREDNISOLONE, PREDNISOLONE reactions: Chorioretinopathy serious: 1 patientsex: 1 drugs: AMPHOTERICIN B, CYTARABINE, DAUNORUBICIN, TRETINOIN reactions: Hypokalaemia serious: 1 patientsex: 2 drugs: BEVACIZUMAB, CAPECITABINE, OXALIPLATIN reactions: Toxic leukoencephalopathy serious: 1 patientsex: 1 drugs: METHYLPHENIDATE HYDROCHLORIDE reactions: Obsessive-compulsive disorder serious: 1 patientsex: 2 drugs: ATORVASTATIN, CALCIUM, DEXAMETHASONE, GABAPENTIN, LACTULOSE reactions: Bone marrow failure, Septic shock serious: 1 patientsex: 1 drugs: CASPOFUNGIN, CYCLOPHOSPHAMIDE, CYTARABINE, ETOPOSIDE, FLUDARABINE PHOSPHATE, INTERLEUKIN-2, MITOXANTRONE HYDROCHLORIDE, MICAFUNGIN SODIUM, SIROLIMUS, VORICONAZOLE reactions: Neutropenia serious: 1 patientsex: 2 drugs: METHOTREXATE, SULFAMETHOXAZOLETRIMETHOPRIM reactions: Drug interaction, Leukopenia, Mouth ulceration, Mucocutaneous ulceration, Renal failure, Toxicity to various agents serious: 1 patientsex: 1 drugs: DACLATASVIR, PEGINTERFERON ALFA-2B, RIBAVIRIN, SOFOSBUVIR reactions: Ascites, Drug ineffective, Pleural effusion, Pericardial effusion serious: 1 patientsex: 1 drugs: ACETAMINOPHENOXYCODONE HYDROCHLORIDE, CELECOXIB, MELOXICAM, TRIAMCINOLONE reactions: Constipation, Drug dependence, Drug withdrawal syndrome, Somnolence serious: 1 patientsex: 2 drugs: ANASTROZOLE, LETROZOLE reactions: Hot flush serious: 1 patientsex: 2 drugs: PREDNISOLONE reactions: Progressive multifocal leukoencephalopathy serious: 1 patientsex: 1 drugs: ACETAMINOPHEN, INFLIXIMAB, PREDNISOLONE reactions: Amyloid goitre, Subacute thyroiditis serious: 1 patientsex: 1 drugs: CLOZAPINE reactions: Cardiac failure, Eosinophilia, Lung infiltration, Myocarditis, Pericardial fluid, Respiratory distress, Tricuspid valve incompetence serious: 1 patientsex: 2 drugs: COBICISTAT, ELVITEGRAVIR, EMTRICITABINE, TENOFOVIR ALAFENAMIDE reactions: Drug interaction, Iridocyclitis, Panuveitis, Product use in unapproved indication serious: 1 patientsex: 2 drugs: ALBUTEROL, PREDNISOLONE, SETRETEXIL, TIOTROPIUM BROMIDE reactions: Cardiac failure congestive, Drug level increased, Hypocalcaemia, Hypokalaemia, Hypomagnaesaemia, Hypothyroidism, Nausea, Sinus tachycardia, Vomiting serious: 1 patientsex: 2 drugs: METHYLPREDNISOLONE, PREDNISOLONE reactions: Adrenal insufficiency, Immune-mediated hepatitis, Immune-mediated neoplasm progression, Immune-mediated thrombocytopenia, Immune-mediated thrombocytopenia, Immune-mediated thrombocytopenia, Immune-mediated thrombocytopenia, Immune-mediated thrombocytopenia, Immune-mediated thrombocytopenia, Immune-mediated thrombocytopenia, Immune-mediated thrombocytopenia, Immune-mediated thrombocytopenia, Immune-mediated thrombocytopenia, Immune-mediated thrombocytopenia, Immune-mediated thrombocytopenia, Immune-mediated thrombocytopenia, Immune-mediated thrombocytopenia, Immune-mediated thrombocytopenia, Immune-mediated thrombocytopenia, Immune-mediated thrombocytopenia, Immune-mediated thrombocytopenia, Immun serious: 1 patientsex: 1 drugs: ACETAMINOPHEN reactions: Acute kidney injury, Cardiac arrest, Overdose, Suicide attempt serious: 1 patientsex: 1 drugs: FINASTERIDE, TAMSULOSIN HYDROCHLORIDE reactions: Drug ineffective serious: 1 patientsex: 2 drugs: AMETHOCAINE HYDROCHLORIDE, LIDOCAINE, POVIDONE-IODINE, RANIBIZUMAB reactions: Intraocular pressure increased serious: 1 patientsex: 1 drugs: CYCLOSPORINE, MYCOPHENOLIC ACID, TACROLIMUS reactions: Multiple organ dysfunction syndrome, Squamous skin carcinoma serious: 1 patientsex: 1 drugs: LEVODOPA, MAGNESIUM reactions: Drug ineffective, Toxicity to various agents serious: 1 patientsex: 1 drugs: ARIPIPRAZOLE, CLONAZEPAM, PROPRANOLOL HYDROCHLORIDE, VALBENAZINE reactions: Drug ineffective, Tardive dyskinesia serious: 1 patientsex: 2 drugs: CAPECITABINE, FLUOROURACIL, LEUCOVORIN, OXALIPLATIN reactions: Neuropathy peripheral serious: 1 patientsex: 1 drugs: LIDOCAINE reactions: Haematuria, Immune thrombocytopenic purpura, Petechiae, Rash erythematous serious: 1 patientsex: 2 drugs: SULFASALAZINE reactions: Posterior reversible encephalopathy syndrome serious: 1 patientsex: 1 drugs: IMATINIB MESYLATE reactions: Testicular cancer serious: 1 patientsex: 1 drugs: PEMBROLIZUMAB reactions: Tubulointerstitial nephritis serious: 1 patientsex: 1 drugs: AMPHOTERICIN B, CASPOFUNGIN, CYCLOSPORINE, FLUDARABINE PHOSPHATE, IMIPENEM, NOREPINEPHRINE, SULFAMETHOXAZOLETRIMETHOPRIM, VANCOMYCIN reactions: Candida infection, Drug ineffective, Pneumocystis jirovecii pneumonia, Septic shock serious: 1 patientsex: 2 drugs: GANCICLOVIR, LAMIVUDINE, NEVIRAPINE, STAVUDINE reactions: Immune-mediated uveitis serious: 1 patientsex: 1 drugs: INTERFERON BETA-1A, RIBAVIRIN reactions: Drug ineffective, Hepatitis B, Hepatitis C, Hepatitis D serious: 1 patientsex: 2 drugs: ANTITUXIMAB reactions: Botulism serious: 1 patientsex: 1 drugs: DAPTOMYCIN, MEROPENEM, VANCOMYCIN reactions: Febrile neutropenia, Pulmonary aspergillosis serious: 1 patientsex: 2 drugs: BISOCODYL, DOCUSATE SODIUMSENNOSIDES A AND B, DEXAMETHASONE, DOXORUBICIN, FLUCONAZOLE, IFOSFAMIDE, LOSARTAN, METOCLOPRAMIDE, NIFEDIPINE, OXYCODONE, PAROXETINE, MESNA, OXYCODONE HYDROCHLORIDE, PAROXETINE HYDROCHLORIDE, MESNA HYDROCHLORIDE, OXYCODONE HYDROCHLORIDE, PAROXETINE HYDROCHLORIDE, THIMAMINE, ONDANSETRON reactions: Drug interaction, Serotonin syndrome serious: 1 patientsex: 2 drugs: ATORVASTATIN CALCIUM, CINNARIZINE, FENOFIBRATE reactions: Drug intolerance, Memory impairment, Muscle spasms, Vertigo serious: 1 patientsex: 1 drugs: ACETAMINOPHEN, LEVOFLOXACIN reactions: Acute kidney injury, Crystal nephropathy serious: 1 patientsex: 2 drugs: ATORVASTATIN CALCIUM, METHYLPREDNISOLONE, NIFEDIPINE reactions: Drug-induced liver injury serious: 1 patientsex: 1 drugs: BEVACIZUMAB, CAPECITABINE, FLUOROURACIL, IRINOTECAN, LEUCOVORIN, OXALIPLATIN, PANITUMUMAB reactions: General physical health deterioration, Jaundice serious: 1 patientsex: 2 drugs: CYCLOPHOSPHAMIDE, LAMOTRIGINE, RITUXIMAB reactions: Bile duct stenosis, Bile duct dilatation, Bile duct stenosis, Bile duct stenosis, Bile duct stenosis, Bile duct stenosis, Bile duct dilatation, Bile duct stenosis, Bile duct stenosis, Bile duct stenosis, Bile duct stenosis, Bile duct stenosis, Bile duct stenosis, Bile duct stenosis, Bile duct stenosis, Bile duct stenosis, Bile duct stenosis, Bile duct stenosis, Bile duct stenosis, Bile duct stenosis, Bile duct stenosis, Bile duct stenosis, Bile duct steno serious: 1 patientsex: 2 drugs: AFATINIB reactions: Decreased appetite, Nausea, Stomatitis serious: 1 patientsex: 1 drugs: METHOTREXATE, PREDNISOLONE reactions: Pulmonary mycosis serious: 1 patientsex: 1 drugs: METHOTREXATE reactions: Acute kidney injury, Hypotension serious: 1 patientsex: 1 drugs: AMLODIPINE BESYLATE, OMEPRAZOLE reactions: Hypomagnesaemia serious: 1 patientsex: 1 drugs: EFAVIRENZ, LAMIVUDINE, ZIDOVUDINE reactions: Buruli ulcer, Drug interaction, Paradoxical drug reaction serious: 1 patientsex: 1 drugs: CYTARABINE, METHOTREXATE, PREDNISOLONE reactions: Death, Neurotoxicity serious: 1 patientsex: 1 drugs: ALBUTEROL, CLONAZEPAM, CLONAZEPAM HYDROCHLORIDE, CLONAZEPAM HYDROCHLORIDE, CLONAZEPAM HYDROCHLORIDE, CLONAZEPAM HYDROCHLORIDE, CLONAZEPAM HYDROCHLORIDE, CLONAZEPAM HYDROCHLORIDE, CLONAZEPAM HYDROCHLORIDE, CLONAZEPAM HYDROCHLORIDE, CLONAZEPAM HYDROCHLORIDE, CLONAZEPAM HYDROCHLORIDE, CLONAZEPAM HYDROCHLORIDE, CLONAZEPAM HYDROCHLORIDE, CLONAZEPAM HYDROCHLORIDE, CLONAZEPAM HYDROCHLORIDE, CLONAZEPAM HYDROCHLORIDE, CLONAZEPAM HYDROCHLORIDE, CLONAZEPAM HYDROCHLORIDE, CLONAZEPAM HYDROCHLORIDE, CL serious: 1 patientsex: 1 drugs: AZACITIDINE, CETUXIMAB, FLUOROURACIL, LEUCOVORIN, OXALIPLATIN reactions: Acute myeloid leukaemia, Anaemia, Neutropenia, Thrombocytopenia serious: 1 patientsex: 1 drugs: CYCLOPHOSPHAMIDE, PACLITAXEL reactions: Febrile neutropenia, Upper respiratory tract infection serious: 1 patientsex: 1 drugs: CLOTIAZEPAM, DIPHENHYDRAMINE, INSULIN ASPART reactions: Diabetic ketoacidosis, Overdose, Respiratory failure, Suicide attempt serious: 1 patientsex: 2 drugs: ANASTROMOL HYDROCHLORIDE reactions: Malignant neoplasm progression serious: 1 patientsex: 1 drugs: POLYETHYLENE GLYCOL 3350 reactions: Cervical odontoid syndrome, Decreased appetite, Leukopenia, Pyrexia, Transverse ligament calcification, Wrong technique in product usage process serious: 1 patientsex: 2 drugs: ACETAMINOPHENHYDROCODONE, DULOXETINE, FENTANYL, GABAPENTIN reactions: Drug ineffective, Quality of life decreased serious: 1 patientsex: 2 drugs: CELECOXIB, LENALIDOMIDE reactions: Hepatic failure, Renal impairment serious: 1 patientsex: 1 drugs: AMLODIPINE BESYLATE, CLONAZEPAM, DIVALPROEX SODIUM, LEVOXOL, HYDRALAZINE HYDROCHLORIDE, LEVOXOL, SIMVASTATIN reactions: Anaemia, Drug ineffective, Myoclonus serious: 1 patientsex: 1 drugs: MYCOPHENOLATE MOFETIL, PREDNISONE, TACROLIMUS reactions: Cerebral toxoplasmosis, Cystozoid cystoides, Disorientation, Disturbance in attention, Disorientation, Herniation, Infarction, Mental status changes, Neurotoxoplasmosis, Tachyzoitis serious: 1 patientsex: 1 drugs: CEFAZOLIN, CHLORQUINE, DAPTOMYCIN, METHOTREXATE, PREDNISOLONE, VANCOMYCIN reactions: Candida infection, Device related infection serious: 1 patientsex: 2 drugs: AMOXICILLIN, LOXOPROFEN, TRANEXAMIC ACID reactions: Meningitis aseptic serious: 1 patientsex: 2 drugs: DENOSUMAB reactions: Osteonecrosis of jaw serious: 1 patientsex: 2 drugs: CISPLATIN, DOXORUBICIN, ETOPOSIDE, IFOSFAMIDE, PREDNISOLONE, SORAFENIB reactions: Drug ineffective, Hypoglycaemia, Loss of consciousness, Mucosal inflammation, Off label use, Product use in unapproved indication serious: 1 patientsex: 1 drugs: CETUXIMAB, FLUOROURACIL, LEUCOVORIN, OXALIPLATIN reactions: Leukopenia serious: 1 patientsex: 1 drugs: VALACYCLOVIR HYDROCHLORIDE reactions: Blood pressure increased, Neurotoxicity serious: 1 patientsex: 2 drugs: AMPHOTERICIN B, BISOPROLOL, CIPROFLOXACIN, CYCLOPHOSPHAMIDE, METHYLPREDNISOLONE, PREDNISOLONE, RITUXIMAB, VANCOMYCIN reactions: Drug ineffective, Pneumonia serious: 1 patientsex: 1 drugs: CYTARABINE, DAUNORUBICIN, ETOPOSIDE, METOXANTRONE HYDROCHLORIDE, VORICONAZOLE reactions: Cholecystitis acute, Febrile neutropenia, Septic shock serious: 1 patientsex: 1 drugs: ARIPIPRAZOLE, CITALOPRAM HYDROBROMIDE, RISPERIDONE reactions: Drug ineffective, Drug resistance, Sleep disorder, Weight increased serious: 1 patientsex: 2 drugs: CARBOPLATIN, DOCETAXEL, FLUCONAZOLE, METHOTREXATE, PACLITAXEL reactions: Hypersensitivity, Off label use serious: 1 patientsex: 1 drugs: IMATINIB MESYLATE reactions: Abdominal fibromatosis serious: 1 patientsex: 2 drugs: APIXABAN, ASPIRIN reactions: Haemoptysis serious: 1 patientsex: 2 drugs: CLOBETASOL reactions: Cushings syndrome, Drug misuse, Hypomyelination, Off label use, Product use issue serious: 1 patientsex: 1 drugs: AMPICILLIN, CYCLOPHOSPHAMIDE, DOXORUBICIN, PREDNISOLONE, VINCRISTINE reactions: Pathogen resistance serious: 1 patientsex: 1 drugs: LISINOPRIL, METFORMIN HYDROCHLORIDE reactions: Acute kidney injury, Hyperkalaemia, Lactic acidosis, Renal tubular necrosis serious: 1 patientsex: 1 drugs: BEVACIZUMAB, CAPECITABINE, FLUOROURACIL, IRINOTECAN, LEUCOVORIN, OXALIPLATIN reactions: Cytokine storm, Chills, Diarrhoea, Febrile neutropenia, Neuropathy peripheral, Vomiting serious: 1 patientsex: 1 drugs: AMOXICILLINCLAVULANIC ACID, DEXAMETHASONE, IBRUTINIB, LEVETIRACETAM, MICAFUNGIN SODIUM, VORICONAZOLE reactions: Aspergillus infection, Gastrointestinal disorder, Nail disorder, Photosensitivity, Toxicity to various agents serious: 1 patientsex: 1 drugs: ARIPIPRAZOLE, DOXYCYCLINE, SERTRALINE HYDROCHLORIDE reactions: Bartonella infection, Drug ineffective serious: 1 patientsex: 1 drugs: GADOBENAT DIMEGLUMINE reactions: Kounis syndrome serious: 1 patientsex: 1 drugs: CYTARABINE, LEUCOVORIN, METHOTREXATE reactions: Drug ineffective serious: 1 patientsex: 1 drugs: DOCETAXEL, FLUOROURACIL, GEMCITABINEGEMCITABINE HYDROCHLORIDE, IRINOTECAN, OXALIPLATIN reactions: Pneumonitis serious: 1 patientsex: 2 drugs: ARIPIPRAZOLE reactions: Drug ineffective serious: 1 patientsex: 2 drugs: ALPRAZOLAM, ASPIRIN, ATORVASTATIN, CLOPIDOGREL BISULFATE, ENOXAPARIN, GLYCERIN, OXYGEN, PANTOPRAZOLE SODIUM, SODIUM CHLORIDE reactions: Gastrointestinal haemorrhage serious: 1 patientsex: 1 drugs: ALTEPLASE reactions: Ischaemic stroke serious: 1 patientsex: 2 drugs: BLEOMYCIN SULFATE, CISPLATIN, ETPOSIDE reactions: Lipodystrophy acquired serious: 1 patientsex: 2 drugs: BORTEZOMIB, DEXAMETHASONE, LENALIDOMIDE, ZOLEDRONIC ACID reactions: Acute kidney injury, Febrile neutropenia, Hypocalcaemia, Pancytopenia, Renal failure, Seizure, Tonic-clonic seizure serious: 1 patientsex: 2 drugs: AZITHROMYCIN ANHYDROUS, AMPICILLIN SODIUMSULBACTAM SODIUM, LEVOFLOXACIN, MINOCYCLINEMINOCYCLINE HYDROCHLORIDE, MEROPENEM, METHYLPREDNISOLONE, PREDNISOLONE reactions: Drug ineffective serious: 1 patientsex: 2 drugs: BORTEZOMIB, DEXAMETHASONE, DOXORUBICIN, LENALIDOMIDE, IBANDRONATE SODIUM, VINCRISTINE reactions: Osteonecrosis of jaw, Necrotising fasciitis serious: 1 patientsex: 2 drugs: ABACAVIR, CALETRA, TENOFOVIR DISOPROXIL FUMARATE reactions: Fanconi syndrome, Wrist fracture serious: 1 patientsex: 1 drugs: ABACAVIR, DOLUTEGRAVIR, LAMIVUDINE reactions: Acute kidney injury, Cytomegalovirus infection, Histoplasmosis disseminated, Immune reconstitution inflammatory syndrome, Pancytopenia serious: 1 patientsex: 2 drugs: NINTEDANIB reactions: Lung adenocarcinoma serious: 1 patientsex: 1 drugs: CISPLATIN, CYCLOPHOSPHAMIDE, DOXORUBICIN, ENOXAPARIN, IFOSFAMIDE, VINCRISTINE reactions: Febrile neutropenia serious: 1 patientsex: 2 drugs: AMOXICILLINCLAVULANIC ACID, CEFTRIAXONE, AZITHROMYCIN ANHYDROUS, CEFTRIAXONE SODIUM PHOSPHATE, CEFTRIAXONE SODIUM, PREDNISOLONE reactions: Drug ineffective, Inflammation, Oral cavity ulcer, Pneumococcal infection, Pneumonia, Pneumonia streptococcal, Periodontitis, Pneumonia recurrent, Pneumonia recurrent, Pneumonia recurrent, Pneumonia recurrent, Pneumonia recurrent, Pneumonia recurrent, Pneumonia recurrent, Pneumonia recurrent, Pneumonia recurrent, Pneumonia recurrent, Pneumonia recurrent, Pneumonia recurrent, Pneumonia recurrent, Pneumonia recurrent, Pneumonia recurrent, Pneumonia recurrent, Pneumonia recurrent, serious: 1 patientsex: 1 drugs: ADEFOVIR DIPIVOXIL, LAMIVUDINE reactions: Drug resistance serious: 1 patientsex: 1 drugs: CYCLOPHOSPHAMIDE, DOXORUBICIN, PREDNISOLONE, VINCRISTINE reactions: Pulmonary toxicity serious: 1 patientsex: 1 drugs: CEFTRIAXONE, DOXYCYCLINE, OSELTAMIVIR, WARFARIN reactions: Acute respiratory distress syndrome, Coagulopathy, Drug ineffective, Multiple organ dysfunction syndrome, Paraphimosis, Priapism, Paralysis serious: 1 patientsex: 1 drugs: CLOZAPINE reactions: Anaemia, Neutropenic sepsis, Pancytopenia, Thrombocytopenia serious: 1 patientsex: 2 drugs: THALIDOMIDE reactions: Drug ineffective serious: 1 patientsex: 1 drugs: CYCLOSPORINE, METHYLPREDNISOLONE, PREDNISOLONE reactions: Drug ineffective, Off label use serious: 1 patientsex: 2 drugs: LANREOTIDE ACETATE reactions: Colitis, Drug ineffective, Intestinal perforation serious: 1 patientsex: 2 drugs: CYCLOSPORINE, PREDNISONE reactions: Drug ineffective, Emotional instability, Nausea, Hirsutism, Nausea, Treatment noncompliance serious: 1 patientsex: 2 drugs: BEVACIZUMAB, CAPECITABINE, CETUXIMAB, FLUOROURACIL, IRINOTECAN, OXALIPLATIN reactions: Dermatitis, Neuropathy peripheral serious: 1 patientsex: 2 drugs: ETHAMBUTOL HYDROCHLORIDE, ISONIAZID, PYRAZINAMIDE, RIFAMPIN reactions: Granulomatous polyangiitis, Otitis, Peritubulitis, Renal failure, Tubulointerstitial nephritis serious: 1 patientsex: 1 drugs: PEMBROLIZUMAB reactions: Myasthenia gravis, Myocarditis serious: 1 patientsex: 1 drugs: BRENTUXIMAB VEDOTIN, METHOTREXATE reactions: Choledochoduodenal fistula serious: 1 patientsex: 1 drugs: POTASSIUM BROMIDE, TOPIRAMATE reactions: Cardiac arrest, Hyperthermia, Seizure serious: 1 patientsex: 2 drugs: CYCLOPHOSPHAMIDE, EPIRUBICIN reactions: Disease progression serious: 1 patientsex: 1 drugs: AZATHIOPRINE, CYCLOPHOSPHAMIDE, HYDROXYCHLOROQUINE, MYCOPHENOLATE MOFETIL, PREDNISOLONE, RITUXIMAB reactions: Acute kidney injury, Cardiac failure, Lupus nephritis, Respiratory failure, Thrombocytopenia serious: 1 patientsex: 2 drugs: CYCLOPHOSPHAMIDE, DOXORUBICIN HYDROCHLORIDE reactions: Acute myeloid leukaemia serious: 1 patientsex: 2 drugs: ARSENIC TRIOXIDE, TRETINOIN reactions: Acute myocardial ischaemia serious: 1 patientsex: 1 drugs: AMOXICILLINCLAVULANATE POTASSIUM reactions: Colitis ischaemic serious: 1 patientsex: 1 drugs: DOXORUBICIN, FLUOROURACIL, IODIZED OIL, HYDROXYCAPTOCIN, SORAFENIB reactions: Skin reaction serious: 1 patientsex: 2 drugs: BISOCODYL, CHLORPHENIRAMINE, HYDROCHLOROTHIAZIDE, SITAGOMINE reactions: Cardiac arrest, Hypokalaemia, Off label use, Ventricular fibrillation serious: 1 patientsex: 2 drugs: METHOTREXATE reactions: Epstein-Barr virus infection, Lymphoproliferative disorder serious: 1 patientsex: 2 drugs: METHOTREXATE, PREDNISOLONE, TACROLIMUS reactions: Drug ineffective, Drug resistance serious: 1 patientsex: 1 drugs: ADALIMUMAB, LEVOFLOXACIN reactions: Interstitial lung disease serious: 1 patientsex: 2 drugs: ACYCLOVIR, ETANERCEPT, METHOTREXATE, PREDNISOLONE, TACROLIMUS, TOCILIZUMAB reactions: Herpes simplex keratitis, Ulcerative keratitis serious: 1 patientsex: 1 drugs: EVEROLIMUS, LEDIPASVIRSOFOSBUVIR, RIBAVIRIN, VELPATASVIR reactions: Drug interaction, Hepatitis C serious: 1 patientsex: 1 drugs: AMPHOTERICIN B, CYCLOSPORINE, METHYLPREDNISOLONE, MYCOPHENOLATE MOFETIL, PREDNISONE, RITUXIMAB, TACROLIMUS reactions: Drug ineffective, Leishmaniasis, Treatment failure serious: 1 patientsex: 2 drugs: ESTROGENS, LEUPROLIDE ACETATE reactions: Acne, Drug interaction, Fatigue, Hot flush, Injection site rash, Mood altered, Mood swings, Weight increased serious: 1 patientsex: 2 drugs: AMANTADINE HYDROCHLORIDE, LEVODOPA reactions: Neuroleptic malignant syndrome serious: 1 patientsex: 2 drugs: CYCLOSPORINE, LEVOFLOXACIN, METHOTREXATE, SULFAMETHOXAZOLETRIMETHOPRIM reactions: Hyperbilirubinaemia, Neutropenia, Urinary tract infection bacterial serious: 1 patientsex: 2 drugs: CLOMIPHENE CITRATE reactions: Abortion spontaneous, Exposure during pregnancy serious: 1 patientsex: 1 drugs: ASPIRIN, ATORVASTATIN, CEPHALEXIN, GABAPENTIN, LOSARTAN, METFORMIN HYDROCHLORIDE, TOLTERODINE reactions: Acute kidney injury, Eosinophilia, Pemphigoid, Renal impairment serious: 1 patientsex: 1 drugs: ASPARAGINASE, CYCLOPHOSPHAMIDE, CYTARABINE, MERCAPTOPURINE, HYDROCORTISONE, METHOTREXATE, PREDNISOLONE, RITUXIMAB, VINCRISTINE reactions: Cerebellar injury, Dysarthria, Dysphonia, Dysphagia, Febrile neutropenia serious: 1 patientsex: 1 drugs: CEFOTAXIME SODIUMSULBACTAM SODIUM, LINEZOLID, MEROPENEM, TIGECYCLINE reactions: Acinetobacter infection, Cerebral arachnoiditis, Hydrocephalus, Subdural sac serious: 1 patientsex: 2 drugs: LAMOTRIGINE, LEVETIRACETAM, VALPROIC ACID reactions: Precocious puberty serious: 1 patientsex: 1 drugs: METHADONE HYDROCHLORIDE, OXYMETHOLONE, OPIUM, TRAMADOL reactions: Acute kidney injury, Drug abuse, Rhabdomyolysis serious: 1 patientsex: 2 drugs: IBANDRONATE SODIUM reactions: Atypical femur fracture serious: 1 patientsex: 1 drugs: RIFAMPIN reactions: Hepatitis serious: 1 patientsex: 1 drugs: AMIFOSTINE, BENDAMUSTINE, CYTARABINE, ETOPOSIDE, IBRITUMOMAB TIUXETAN, MELPHALAN reactions: Febrile neutropenia serious: 1 patientsex: 2 drugs: DOCETAXEL, PERTUZUMAB, TRASTUZUMAB reactions: Hepatic enzyme increased, Hepatic function abnormal serious: 1 patientsex: 1 drugs: PACLITAXEL reactions: Angina unstable, Incorrect route of drug administration, Neointima serious: 1 patientsex: 2 drugs: AMIODARONE, ATENOLOL, MAGNESIUM reactions: Drug ineffective, Exposure during pregnancy, Right ventricular tachycardia serious: 1 patientsex: 2 drugs: AMLODIPINE BESYLATE reactions: Acute kidney injury serious: 1 patientsex: 1 drugs: ERLOTINIB, PACLITAXEL reactions: Pulmonary alveolar haemorrhage serious: 1 patientsex: 2 drugs: BETAMETHASONE, MAGNESIUM SULFATE, RITODRINE HYDROCHLORIDE, SODIUM CHLORIDE reactions: Acute pulmonary hypertension, Ascites, Cardiothoracic ratio increased, Dyspnoea, Foetal exposure during pregnancy, Premature baby, Uterine contractions serious: 1 patientsex: 1 drugs: CYCLOPHOSPHAMIDE, DOXORUBICIN, PREDNISOLONE, VINCRISTINE reactions: Death, Metastases to adrenal gland, Metastases to liver, Metastases to lymph nodes, Pyrexia, Respiratory failure serious: 1 patientsex: 1 drugs: LENALIDOMIDE reactions: Myeloma, Thrombocytopenia serious: 1 patientsex: 2 drugs: AMLODIPINE BESYLATE, ASPIRIN, ATORVASTATIN, CILOSTAZOL, CLOPIDOGREL BISULFATE, HYDRALAZINE HYDROCHLORIDE, LEVOTHYROXINE, PERIODIZED OIL reactions: Cerebral artery ischaemia, Drug-induced liver injury, Lupus serious: 2 patientsex: 2 drugs: CLONIDINE, EZECOPICLONE, GABAPENTIN, MAGNESIUM, NAPROXEN, TOPIRAMATE, VALERIAN RATE reactions: Drug ineffective serious: 1 patientsex: 2 drugs: CARBAMAZEPINE reactions: Drug ineffective serious: 1 patientsex: 2 drugs: ACETAMINOPHEN, METHOTREXATE, TOCILIZUMAB reactions: Drug-induced liver injury serious: 1 patientsex: 2 drugs: AMITRIPTYLINE, TILIDINE reactions: Acute kidney injury, Electrocardiogram QT prolonged, Intentional overdose, Suicide attempt, Toxicity to various agents serious: 1 patientsex: 2 drugs: AMLODIPINE BESYLATE reactions: Acute kidney injury, Capillary leak syndrome, Hypoxia, Overdose, Respiratory failure, Shock serious: 1 patientsex: 2 drugs: AXITINIB, PAZOPANIB, SUNITINIB reactions: Acute kidney injury, Disseminated intravascular coagulation, Tumour lysis syndrome serious: 1 patientsex: 1 drugs: ASPIRIN, CYCLOPHOSPHAMIDE, CYTARABINE, METHOTREXATE, PREDNISOLONE, RITUXIMAB, VINCRISTINE reactions: Drug ineffective, Off label use serious: 1 patientsex: 1 drugs: MYCOPHENOLATE MOFETIL, PREDNISOLONE, TACROLIMUS reactions: Polyomavirus-associated nephropathy serious: 1 patientsex: 1 drugs: AMIODARONE, DOPETHALIDINE, FLECAINIDE, SOTALOL reactions: Atrial fibrillation, Drug ineffective serious: 1 patientsex: 1 drugs: PEGINTERFERON ALFA-2B, RIBAVIRIN reactions: Drug ineffective, Pathogen resistance serious: 1 patientsex: 2 drugs: ATOVAQUONE, SULFAS reactions: Pneumocystis jirovecii pneumonia, Respiratory failure serious: 1 patientsex: 1 drugs: METHOTREXATE, PREDNISOLONE reactions: Interstitial lung disease, Pleural effusion, Pulmonary cryptococcosis serious: 1 patientsex: 1 drugs: EXEMESTANE, METHYLPREDNISOLONE, METHYLPREDNISOLONE SODIUM SUCCINATE, METHYLPREDNISOLONE ACETATE, TALADAFIL reactions: Drug-induced liver injury, Off label use, Renal failure serious: 1 patientsex: 2 drugs: INDOMETHACIN reactions: Foetal exposure during pregnancy, Premature baby serious: 1 patientsex: 1 drugs: BICALUTAMIDE, GOSERELIN reactions: Squamous cell carcinoma serious: 1 patientsex: 2 drugs: BUDENOSIDES, IPRATROPIUM BROMIDE reactions: Anisocoria serious: 1 patientsex: 1 drugs: ENTECAVIR, PREDNISONE, TACROLIMUS reactions: Diffuse large B-cell lymphoma, Hepatitis B reactivation serious: 1 patientsex: 1 drugs: ANAKINRA reactions: Anaphylactic reaction, Chest discomfort, Drug hypersensitivity, Injection site pruritus, Injection site swelling, Mouth ulceration, Pruritus, Pyrexia, Rash, Rash erythematous, Rash erythematous, Rash erythematous, Rash erythematous, Rash erythematous, Rash erythematous, Rash erythematous, Rash erythematous, Rash erythematous, Rash erythematous, Rash erythematous, Rash erythematous, Rash erythematous, Rash erythematous, Rash erythematous, Rash erythematous, Rash erythematous, Rash erythematous, Rash erythematous, Rash erythematous, Rash erythematous, Rash erythematous, Rash erythematous, Rash erythematous, Rash ery serious: 1 patientsex: 1 drugs: AZATHIOPRINE, METHYLPREDNISOLONE, PREDNISOLONE, RITUXIMAB reactions: Tubulointerstitial nephritis serious: 1 patientsex: 2 drugs: MYCOPHENOLATE MOFETIL, PREDNISOLONE, TACROLIMUS reactions: Optic ischaemic neuropathy serious: 1 patientsex: 2 drugs: CARBOPLATIN, PEMBROLIZUMAB, PEMETREXED reactions: Infection, Performance status decreased, Pelvic pain serious: 1 patientsex: 2 drugs: AZITHROMYCIN ANHYDROUS, HYDROXYCHLOROQUINE reactions: Electrocardiogram QT prolonged, Exposure during pregnancy serious: 1 patientsex: 2 drugs: CYTARABINE, DASATINIB, RITUXIMAB reactions: Clostridium difficile colitis, COVID-19 pneumonia serious: 1 patientsex: 1 drugs: BUPROPION reactions: Tardive dyskinesia serious: 1 patientsex: 2 drugs: BISOPROLOL FUMARATE reactions: Dizziness, Drug ineffective, Heart failure, Nausea serious: 1 patientsex: 1 drugs: BUPRENORPHINE reactions: Acute hepatic failure, Drug abuse, Jaundice, Nausea, Vomiting serious: 1 patientsex: 2 drugs: DAPSONE reactions: Cholestasis, Aplasia pure red cell serious: 1 patientsex: 1 drugs: CISPLATIN, DOXORUBICIN, ETOPOSIDE, HYDROCORTISONE, MITOTANE, SUNITINIB reactions: Drug ineffective serious: 1 patientsex: 1 drugs: BLEOMYCIN SULFATE, CISPLATIN, ETOPOSIDE reactions: Cerebral venous sinus thrombosis serious: 1 patientsex: 2 drugs: ASPIRIN, CYCLOPHOSPHAMIDE, DOXORUBICIN, PREDNISOLONE, VINCRISTINE reactions: Anuria, Drug ineffective, Renal impairment serious: 1 patientsex: 2 drugs: ACETAMINOPHEN, CELECOXIB, CRIZOTINIB, ESOMEPRAZOLE MAGNESIUM MAGNESIUM HYDROCHLORIDE, LEVOCETIRIZINE HYDROCHLORIDE, MAGNESIUM OXIDE, METOCLOPRAMIDE, MORPHINE SULFATE HYDROCHLORIDE, MAGNESIUM OXIDE reactions: Neutropenia serious: 1 patientsex: 1 drugs: APIXABAN reactions: Vascular pseudoaneurysm serious: 1 patientsex: 1 drugs: CALCITONIN, CALCIUM, CHOLECALCIFEROL, DEFERIPRONE, HYDROCHLOROTHIAZIDERAMIPRIL, MAGNESIUM, METFORMIN HYDROCHLORIDE, SOTALOL, ZOLEDRONIC ACID reactions: Atypical femur fracture serious: 1 patientsex: 2 drugs: APIXABAN reactions: Acute kidney injury, Atrial fibrillation, Acute kidney injury, Hypovolaemia, Rhabdomyolysis, Renal haematoma serious: 1 patientsex: 1 drugs: CLOZAPINE reactions: Gastrointestinal ischaemia serious: 1 patientsex: 2 drugs: CYCLOPHOSPHAMIDE, ELTROMBOPAG, HUMAN IMMUNOGLOBULIN G, ROMIPLOSTIM, RITUXIMAB, VINBLASTINE reactions: Drug ineffective serious: 1 patientsex: 2 drugs: CYCLOSPORINE, METHOTREXATE, PREDNISOLONE, RITUXIMAB reactions: Epstein-Barr virus infection, Post transplant lymphoproliferative disorder serious: 1 patientsex: 1 drugs: METHOTREXATE, PREDNISONE reactions: Meningitis listeria serious: 1 patientsex: 2 drugs: HYDROCORTISONE, MYCOPHENOLATE MOFETIL, PREDNISONE reactions: Posterior reversible encephalopathy syndrome, Visual impairment serious: 1 patientsex: 2 drugs: CYCLOPHOSPHAMIDE, DOXORUBICIN, PREDNISOLONE, RITUXIMAB, VINCRISTINE reactions: Neutropenia serious: 1 patientsex: 2 drugs: FLUOCINONIDE reactions: Central serous retinal detachment serious: 1 patientsex: 1 drugs: BICALUTAMIDE, LEUPROLIDE ACETATE reactions: Drug ineffective, Prostate cancer recurrent serious: 1 patientsex: 1 drugs: ATROPINE, FENTANYL, LIDOCAINE, PROPOFOL, REMIFENTANIL, ROCURONIUM BROMIDE, SEVOFLURANE reactions: Accelerated idioventricular rhythm serious: 1 patientsex: 1 drugs: EZETIMIBE reactions: Drug-induced liver injury serious: 1 patientsex: 2 drugs: BENDAMUSTINE, CYCLOPHOSPHAMIDE, DEXAMETHASONE, ETOPOSIDE, MELPHALAN, PREDNISOLONE, RITUXIMAB reactions: Hypogammaglobulinaemia, Lymphoenteric fistula serious: 1 patientsex: 2 drugs: BETAMETHASONE, CALCITONIN, CALCIUM SULFATE, LABETALOLLABETALOL HYDROCHLORIDE, MAGNESIUM SULFATE reactions: Confusional state, Exposure during pregnancy, Mental status changes, Pancreatitis acute serious: 1 patientsex: 1 drugs: CISPLATIN, PACLITAXEL reactions: Drug eruption, Hypersensitivity, Rash pruritic serious: 1 patientsex: 2 drugs: ADALIMUMAB, SALAZOPYRIN reactions: Osteonecrosis of jaw serious: 1 patientsex: 2 drugs: PROPAFENONE HYDROCHLORIDE reactions: Brugada syndrome, Overdose, Suicide attempt serious: 1 patientsex: 1 drugs: CLONAZEPAM, CLONAZEPAM HYDROCHLORIDE, HALOPERIDOL, OLANZAPINE, QUETIAPINE, ZUCLPENTHIXOL reactions: Neuroleptic malignant syndrome serious: 1 patientsex: 2 drugs: AZITHROMYCIN ANHYDROUS, CEFTRIAXONE, HYDROXYCHLOROQUINE, TOCILIZUMAB reactions: Foetal death, Foetal exposure during pregnancy, Low birth weight baby, Premature baby serious: 1 patientsex: 2 drugs: CALCITRIOL, LEVOTHYROXINE, OCTREOTIDE, VANDETANIB reactions: Metastases to liver, Metastases to lymph nodes, Metastases to intestine, Multiple organ dysfunction syndrome, Thyroid cancer stage IV serious: 1 patientsex: 1 drugs: HEPARIN SODIUM reactions: Acute respiratory failure, Cerebral haemorrhage, Haemoglobin decreased, Hemiplegia, Paraneural haemorrhage, Ventricular thrombosis serious: 1 patientsex: 1 drugs: AZITHROMYCIN ANHYDROUS, CEFOPERAZONE SODIUM, ORNIDAZOLE, SULBACTAM SODIUM reactions: Drug ineffective serious: 1 patientsex: 2 drugs: CYCLOPHOSPHAMIDE, DOCETAXEL, DOXORUBICIN reactions: Febrile neutropenia, Sepsis serious: 1 patientsex: 1 drugs: AZITHROMYCIN ANHYDROUS, HYDROXYCHLOROQUINE, METHYLPREDNISOLONE, MYCOPHENOLATE MOFETIL, TACROLIMUS reactions: COVID-19 serious: 1 patientsex: 2 drugs: EFAVIRENZ, LAMIVUDINE, TENOFOVIR DISOPROXIL FUMARATE reactions: Stevens-Johnson syndrome serious: 1 patientsex: 2 drugs: ENOXAPARIN, WARFARIN reactions: Haematochezia, Shock serious: 1 patientsex: 1 drugs: CISPLATIN reactions: Mesenteric ischaemia serious: 1 patientsex: 1 drugs: ASPIRIN, HUMAN IMMUNOGLOBULIN G reactions: Haematochezia, Rectal ulcer serious: 1 patientsex: 2 drugs: IRBESARTAN reactions: Metastases to skin, Metastases to abdominal wall serious: 1 patientsex: 1 drugs: APIXABAN reactions: Haemophilia A, Plasma cell myeloma serious: 1 patientsex: 1 drugs: MOXIFLOXACIN, TRIAMCINOLONE ACETONIDE reactions: Scleral abscess serious: 1 patientsex: 1 drugs: COLISTIN, METHYLPREDNISOLONE reactions: Drug interaction, Nephropathy toxic serious: 1 patientsex: 2 drugs: FLUOXETINE HYDROCHLORIDE, MIANSERIN, SERTRALINE HYDROCHLORIDE reactions: Drug ineffective, Hypomania, Extrapyramidal disorder serious: 1 patientsex: 2 drugs: ACETAMINOPHENHYDROCODONE, BUPIVACAINE, FENTANYL, HYDROCODONE HYDROCHLORIDE, LIDOCAINE, METHYLPREDNISOLONE, TRAMADOL reactions: Drug ineffective, Hallucination, Pain, Pudendal neuralgia, Suicide attempt serious: 1 patientsex: 1 drugs: CYCLOPHOSPHAMIDE, DOXORUBICIN, PREDNISONE, RITUXIMAB, VINCRISTINE reactions: Acute kidney injury, Haemolytic anaemia, Hyperkalaemia, Metastases to kidney, Tumour lysis syndrome serious: 1 patientsex: 2 drugs: PREDNISONE, SIROLIMUS, TACROLIMUS reactions: Intestinal angioedema serious: 1 patientsex: 1 drugs: ESCITALOPRAM OXALATE, TESTOSTERONE, TRENBOLONE ACETATE reactions: Acute kidney injury, Renal infarct serious: 1 patientsex: 1 drugs: AMLODIPINE BESYLATE, METHOTREXATE, TELMISARTAN reactions: Incorrect drug administration duration, Pustular psoriasis serious: 1 patientsex: 1 drugs: BACLOFEN, ESCITALOPRAM OXALATE, LORAZEPAM, MIRTAZEPINE, QUETIAPINE reactions: Drug abuse, Drug dependence, Drug dependence serious: 1 patientsex: 2 drugs: ESCITALOPRAM OXALATE reactions: Angle closure glaucoma serious: 1 patientsex: 2 drugs: PACLITAXEL reactions: Pseudomonas infection, Urinary tract infection serious: 1 patientsex: 2 drugs: DOXAZOSIN MESYLATE, HEPARIN SODIUM, ROSUVASTATIN, TOLVAPTAN reactions: Haemorrhage retroperitoneal serious: 1 patientsex: 2 drugs: CISPLATIN, MANNITOL, PACLITAXEL, PREDNISONE, SODIUM CHLORIDE reactions: Acute kidney injury, Febrile neutropenia, Off label use, Product use in unapproved indication serious: 1 patientsex: 2 drugs: ATORVASTATIN, CLINDAMYCIN, FUSIDIC ACID reactions: Drug interaction, Rhabdomyolysis serious: 1 patientsex: 2 drugs: ETHINYL ESTRADIOL, GONAPEPTYL, MESALAMINE, SILDENAFIL CITRATE reactions: Abortion spontaneous, Maternal exposure during pregnancy, Premature delivery serious: 1 patientsex: 2 drugs: CLOZAPINE, QUETIAPINE FUMARATE reactions: Akathisia serious: 1 patientsex: 1 drugs: AZATHIOPRINE, DOXYCYCLINE, NICOTINAMIDE, PREDNISOLONE reactions: Kaposis varicelliform eruption serious: 1 patientsex: 2 drugs: CAPECITABINE reactions: Palmoplantar erythrodysaesthesia syndrome serious: 1 patientsex: 2 drugs: PACLITAXEL, TOPOTECAN HYDROCHLORIDE reactions: Anaemia, Dry eye, Dry eye, Dry eye, Dry eye, Glaucoma, Lymphocytopenia, Thrombocytopenia serious: 1 patientsex: 2 drugs: CYCLOSPORINE, MYCOPHENOLIC ACID, PREDNISOLONE reactions: Rhabdomyosarcoma serious: 1 patientsex: 1 drugs: SORAFENIB reactions: Hepatotoxicity, Off label use serious: 1 patientsex: 1 drugs: IMATINIB MESYLATE, PREDNISOLONE reactions: Aplasia pure red cell serious: 1 patientsex: 1 drugs: CISPLATIN, DOCETAXEL, ETOPOSIDE reactions: Septic shock serious: 1 patientsex: 2 drugs: METHYLPREDNISOLONE, PREDNISOLONE reactions: Haemorrhage intracranial, Neuromyelitis optica spectrum disorder serious: 1 patientsex: 1 drugs: POTASSIUM PARAMAMINOBENZOATE, SIMVASTATIN reactions: Drug-induced liver injury serious: 1 patientsex: 1 drugs: OSELTAMIVIR reactions: Acute respiratory distress syndrome, Acute respiratory distress syndrome, Multiple organ dysfunction syndrome, Septic shock serious: 1 patientsex: 2 drugs: DEMEROXIL, PHENERGAN reactions: Nicolau syndrome serious: 1 patientsex: 1 drugs: INSULIN NOS, METFORMIN HYDROCHLORIDE reactions: Drug ineffective, Respiratory tract infection serious: 1 patientsex: 1 drugs: CARBOPLATIN, EMTRICITABINE, DOLUTEGRAVIR, EMTRICITABINETENOFOVIR DISOPROXIL FUMARATE, PEMBROLIZUMAB, PEMETREXED reactions: Diabetic ketoacidosis, Type 1 diabetes mellitus serious: 1 patientsex: 2 drugs: DACARBAZINE, DOXORUBICIN HYDROCHLORIDE, IFOSFAMIDE, MESNA reactions: Acratia, Anaemia, Leukopenia, Neutropenia, Nausea serious: 1 patientsex: 2 drugs: NATALIZUMAB reactions: Progressive multifocal leukoencephalopathy serious: 1 patientsex: 2 drugs: LENVATINIB reactions: Fatigue, Hyperthyroidism, Thrombocytopenia serious: 1 patientsex: 2 drugs: MYCOPHENOLIC ACID, PREDNISONE, TACROLIMUS, VALGANCICLOVIR reactions: Diverticulitis serious: 1 patientsex: 1 drugs: CYCLOPHOSPHAMIDE, DOXORUBICIN, PREDNISONE, VINCRISTINE reactions: Device related infection, Staphylococcal bacteraemia serious: 1 patientsex: 1 drugs: DIAZEPAM, FLUMAZENIL, OLANZAPINE, QUETIAPINE, THIAMYLAL reactions: Drug ineffective, Pneumonia aspiration serious: 1 patientsex: 1 drugs: CISPLATIN, DOCETAXEL, DEXAMETHASONE, FAMOTIDINE, GRANISETRON, PACLITAXEL, PALONOSETRON HYDROCHLORIDE reactions: Diarrhoea serious: 1 patientsex: 1 drugs: AMPICILLIN, AMPICILLIN SODIUMSULBACTAM SODIUM, AMPICILLIN SODIUMSULBACTAM SODIUM, AMPICILLIN SODIUMSULBACTAM SODIUM, AMPICILLIN SODIUMSULBACTAM SODIUM, AMPICILLIN SODIUMSULBACTAM SODIUM, AMPICILLIN SODIUMSULBACTAM SODIUM, AMPICILLIN SODIUMSULBACTAM SODIUM, AMPICILLIN SODIUMSULBACTAM SODIUM, AMPICILLIN SODIUMSULBACTAM SODIUM, AMPICILLIN SODIUMSULBACTAM SODIUM, AMPICILLIN SODIUMSULBACTAM SODIUM, AMPICILLIN SODIUMSULBACTAM SODIUM, AMPICILLIN SODIUMSULB serious: 1 patientsex: 1 drugs: CYCLOPHOSPHAMIDE, DOXORUBICIN, PREDNISOLONE, VINCRISTINE reactions: Cerebrovascular accident, Hemiparesis serious: 1 patientsex: 1 drugs: GABAPENTIN reactions: Myasthenia gravis serious: 1 patientsex: 1 drugs: FUROSEMIDE, TENOFOVIR DISOPROXIL FUMARATE, SPIRONOLACTONE reactions: Acute kidney injury, Lactic acidosis, Multiple organ dysfunction syndrome serious: 1 patientsex: 2 drugs: LAMIVUDINE, NEVIRAPINE, STAVUDINE reactions: Rash maculo-papular serious: 2 patientsex: 2 drugs: ARIPIPRAZOLE reactions: Drug ineffective serious: 1 patientsex: 2 drugs: DEXAMETHASONE, METHYLPREDNISOLONE, OXYGEN, PREDNISOLONE reactions: Drug ineffective, Posterior reversible encephalopathy syndrome serious: 1 patientsex: 2 drugs: DOXORUBICIN HYDROCHLORIDE, TRASTUZUMAB reactions: Cardiotoxicity serious: 1 patientsex: 2 drugs: FLUOROURACIL, LEUCOVORIN, OXALIPLATIN reactions: Tumour marker increased serious: 1 patientsex: 2 drugs: ERLOTINIB reactions: Drug resistance serious: 1 patientsex: 2 drugs: IBUPROFEN, NALTREXONE, ETHINYL ESTRADIOL, VENLAFAXINE HYDROCHLORIDE reactions: Angioedema, Drug eruption, Pruritus, Urticaria serious: 1 patientsex: 1 drugs: ADALIMUMAB, AZATHIOPRINE, CYCLOSPORINE, CALCIUM, CHOLECALCIFEROL, CYCLOSPORINE, CYCLOSPORINE HYDROCHLORIDE, IRON, METHYLPREDNISOLONE, PREDNISONE, SIROLIMUS reactions: Drug ineffective